VLTI auxiliary telescopes: a full object-oriented approach

NASA Astrophysics Data System (ADS)

Chiozzi, Gianluca; Duhoux, Philippe; Karban, Robert

2000-06-01

The Very Large Telescope (VLT) Telescope Control Software (TCS) is a portable system. It is now in use or will be used in a whole family of ESO telescopes VLT Unit Telescopes, VLTI Auxiliary Telescopes, NTT, La Silla 3.6, VLT Survey Telescope and Astronomical Site Monitors in Paranal and La Silla). Although it has been developed making extensive usage of Object Oriented (OO) methodologies, the overall development process chosen at the beginning of the project used traditional methods. In order to warranty a longer lifetime to the system (improving documentation and maintainability) and to prepare for future projects, we have introduced a full OO process. We have taken as a basis the United Software Development Process with the Unified Modeling Language (UML) and we have adapted the process to our specific needs. This paper describes how the process has been applied to the VLTI Auxiliary Telescopes Control Software (ATCS). The ATCS is based on the portable VLT TCS, but some subsystems are new or have specific characteristics. The complete process has been applied to the new subsystems, while reused code has been integrated in the UML models. We have used the ATCS on one side to tune the process and train the team members and on the other side to provide a UML and WWW based documentation for the portable VLT TCS.

First Images from the PIONIER/VLTI optical interferometry imaging survey of Herbig Ae/Be stars

NASA Astrophysics Data System (ADS)

Kluska, Jacques; Malbet, Fabien; Berger, Jean-Philippe; Benisty, Myriam; Lazareff, Bernard; Le Bouquin, Jean-Baptiste; Baron, Fabien; Dominik, Carsten; Isella, Andrea; Juhasz, Attila; Kraus, Stefan; Lachaume, Régis; Ménard, François; Millan-Gabet, Rafael; Monnier, John; Pinte, Christophe; Thi, Wing-Fai; Thiébaut, Eric; Zins, Gérard

2013-07-01

The morphology of the close environment of herbig stars is being revealed step by step and appears to be quite complex. Many physical phenomena could interplay : the dust sublimation causing a puffed-up inner rim, a dusty halo, a dusty wind or an inner gaseous component. To investigate more deeply these regions, getting images at the first Astronomical Unit scale is crucial. This has become possible with near infrared instruments on the VLTi. We are carrying out the first Large Program survey of HAeBe stars with statistics on the geometry of these objects at the first astronomical unit scale and the first images of the very close environment of some of them. We have developed a new numerical method specific to young stellar objects which removes the stellar component reconstructing an image of the environment only. To do so we are using the differences in the spectral behaviour between the star and its environment. The images reveal the environement which is not polluted by the star and allow us to derive the best fit for the flux ratio and the spectral slope between the two components (stellar and environmental). We present the results of the survey with some statistics and the frist images of Herbig stars made by PIONIER on the VLTi.

Blind operation of optical astronomical interferometers options and predicted performance

NASA Astrophysics Data System (ADS)

Beckers, Jacques M.

1991-01-01

Maximum sensitivity for optical interferometers is achieved only when the optical path lengths between the different arms can be equalized without using interference fringes on the research object itself. This is called 'blind operation' of the interferometer. This paper examines different options to achieve this, focusing on the application to the Very Large Telescope Interferometer (VLTI). It is proposed that blind operation should be done using a so-called coherence autoguider, working on an unresolved star of magnitude V = 11-13 within the isoplanatic patch for coherencing, which has a diameter of about 1 deg. Estimates of limiting magnitudes for the VLTI are also derived.

The VLTI Roadmap

NASA Astrophysics Data System (ADS)

Mérand, A.

2018-03-01

ESO's Very Large Telescope Interferometer (VLTI) was a unique facility when it was conceived more than 30 years ago, and it remains competitive today in the field of milli-arcsecond angular resolution astronomy. Over the past decade, while the VLTI matured into an operationally efficient facility, it became limited by its first-generation instruments. As the second generation of VLTI instrumentation achieves first light, further developments for this unique facility are being planned and are described here.

CIAO: wavefront sensors for GRAVITY

NASA Astrophysics Data System (ADS)

Scheithauer, Silvia; Brandner, Wolfgang; Deen, Casey; Adler, Tobias; Bonnet, Henri; Bourget, Pierre; Chemla, Fanny; Clenet, Yann; Delplancke, Francoise; Ebert, Monica; Eisenhauer, Frank; Esselborn, Michael; Finger, Gert; Gendron, Eric; Glauser, Adrian; Gonte, Frederic; Henning, Thomas; Hippler, Stefan; Huber, Armin; Hubert, Zoltan; Jakob, Gerd; Jochum, Lieselotte; Jocou, Laurent; Kendrew, Sarah; Klein, Ralf; Kolb, Johann; Kulas, Martin; Laun, Werner; Lenzen, Rainer; Mellein, Marcus; Müller, Eric; Moreno-Ventas, Javier; Neumann, Udo; Oberti, Sylvain; Ott, Jürgen; Pallanca, Laurent; Panduro, Johana; Ramos, Jose; Riquelme, Miguel; Rohloff, Ralf-Rainer; Rousset, Gérard; Schuhler, Nicolas; Suarez, Marcos; Zins, Gerard

2016-07-01

GRAVITY is a second generation near-infrared VLTI instrument that will combine the light of the four unit or four auxiliary telescopes of the ESO Paranal observatory in Chile. The major science goals are the observation of objects in close orbit around, or spiraling into the black hole in the Galactic center with unrivaled sensitivity and angular resolution as well as studies of young stellar objects and evolved stars. In order to cancel out the effect of atmospheric turbulence and to be able to see beyond dusty layers, it needs infrared wave-front sensors when operating with the unit telescopes. Therefore GRAVITY consists of the Beam Combiner Instrument (BCI) located in the VLTI laboratory and a wave-front sensor in each unit telescope Coudé room, thus aptly named Coudé Infrared Adaptive Optics (CIAO). This paper describes the CIAO design, assembly, integration and verification at the Paranal observatory.

The VLTI: An Ever Improving Imaging Machine

NASA Astrophysics Data System (ADS)

Merand, Antoine

2018-04-01

The last decade has seen VLTI transitioning from 2 to 3 to 4 Telescopes recombination. This led to an increase in the morphological complexity observations are able to address, and ultimately the possibility to reconstruct images. Reconstructing images using 4T data only is not a simple feat and requires coordinated observations with multiple re-configurations of VLTI moving telescopes, the Auxiliary Telescopes (AT). Whereas the current second generation instruments (GRAVITY and MATISSE) combine the 4 currently available telescopes, the VLTI platform can accommodate many more telescopes, and the tunnel has space for 2 more delay lines, allowing to combine simultaneously up to 8 telescopes. I will have a look at how VLTI could evolve to include and operate additional telescopes, as well as the improvements (and limitations) related to imaging stellar surfaces.

The environment of the fast rotating star Achernar. III. Photospheric parameters revealed by the VLTI

NASA Astrophysics Data System (ADS)

Domiciano de Souza, A.; Kervella, P.; Moser Faes, D.; Dalla Vedova, G.; Mérand, A.; Le Bouquin, J.-B.; Espinosa Lara, F.; Rieutord, M.; Bendjoya, P.; Carciofi, A. C.; Hadjara, M.; Millour, F.; Vakili, F.

2014-09-01

Context. Rotation significantly impacts on the structure and life of stars. In phases of high rotation velocity (close to critical), the photospheric structure can be highly modified, and present in particular geometrical deformation (rotation flattening) and latitudinal-dependent flux (gravity darkening). The fastest known rotators among the nondegenerate stars close to the main sequence, Be stars, are key targets for studying the effects of fast rotation on stellar photospheres. Aims: We seek to determine the purely photospheric parameters of Achernar based on observations recorded during an emission-free phase (normal B phase). Methods: Several recent works proved that optical/IR long-baseline interferometry is the only technique able to sufficiently spatially resolve and measure photospheric parameters of fast rotating stars. We thus analyzed ESO-VLTI (PIONIER and AMBER) interferometric observations of Achernar to measure its photospheric parameters by fitting our physical model CHARRON using a Markov chain Monte Carlo method. This analysis was also complemented by spectroscopic, polarimetric, and photometric observations to investigate the status of the circumstellar environment of Achernar during the VLTI observations and to cross-check our model-fitting results. Results: Based on VLTI observations that partially resolve Achernar, we simultaneously measured five photospheric parameters of a Be star for the first time: equatorial radius (equatorial angular diameter), equatorial rotation velocity, polar inclination, position angle of the rotation axis projected on the sky, and the gravity darkening β coefficient (effective temperature distribution). The close circumstellar environment of Achernar was also investigated based on contemporaneous polarimetry, spectroscopy, and interferometry, including image reconstruction. This analysis did not reveal any important circumstellar contribution, so that Achernar was essentially in a normal B phase at least from mid-2009 to end-2012, and the model parameters derived in this work provide a fair description of its photosphere. Finally, because Achernar is the flattest interferometrically resolved fast rotator to-date, the measured β and flattening, combined with values from previous works, provide a crucial test for a recently proposed gravity darkening model. This model offers a promising explanation to the fact that the measured β parameter decreases with flattening and shows significantly lower values than the classical prediction of von Zeipel. Based on observations performed at ESO, Chile under VLTI PIONIER and AMBER programme IDs 087.D-0150 and 084.D-0456.

VINCI: the VLT Interferometer commissioning instrument

NASA Astrophysics Data System (ADS)

Kervella, Pierre; Coudé du Foresto, Vincent; Glindemann, Andreas; Hofmann, Reiner

2000-07-01

The Very Large Telescope Interferometer (VLTI) is a complex system, made of a large number of separated elements. To prepare an early successful operation, it will require a period of extensive testing and verification to ensure that the many devices involved work properly together, and can produce meaningful data. This paper describes the concept chosen for the VLTI commissioning instrument, LEONARDO da VINCI, and details its functionalities. It is a fiber based two-way beam combiner, associated with an artificial star and an alignment verification unit. The technical commissioning of the VLTI is foreseen as a stepwise process: fringes will first be obtained with the commissioning instrument in an autonomous mode (no other parts of the VLTI involved); then the VLTI telescopes and optical trains will be tested in autocollimation; finally fringes will be observed on the sky.

HD139614: the Interferometric Case for a Group-Ib Pre-Transitional Young Disk

NASA Technical Reports Server (NTRS)

Labadie, Lucas; Matter, Alexis; Kreplin, Alexander; Lopez, Bruno; Wolf, Sebastian; Weigelt, Gerd; Ertel, Steve; Berger, Jean-Philippe; Pott, Jorg-Uwe; Danchi, William C.

2014-01-01

The Herbig Ae star HD139614 is a group-Ib object, which featureless SED indicates disk flaring and a possible pre-transitional evolutionary stage. We present mid- and near-IR interferometric results collected with MIDI, AMBER and PIONIER with the aim of constraining the spatial structure of the 0.1-10 AU disk region and assess its possible multi-component structure. A two-component disk model composed of an optically thin 2-AU wide inner disk and an outer temperature-gradient disk starting at 5.6 AU reproduces well the observations. This is an additional argument to the idea that group-I HAeBe inner disks could be already in the disk-clearing transient stage. HD139614 will become a prime target for mid-IR interferometric imaging with the second-generation instrument MATISSE of the VLTI.

Interferometric observations of η Carinae with VINCI/VLTI

NASA Astrophysics Data System (ADS)

Kervella, P.

2007-03-01

Context: The bright star η Carinae is the most massive and luminous star in our region of the Milky Way. Though it has been extensively studied using many different techniques, its physical nature and the mechanism that led to the creation of the Homunculus nebula are still debated. Aims: We aimed at resolving the central engine of the η Carinae complex in the near-infrared on angular scales of a few milliarcseconds. Methods: We used the VINCI instrument of the VLTI to recombine coherently the light from two telescopes in the K band. Results: We report a total of 142 visibility measurements of η Car, part of which were analyzed by Van Boekel et al. (2003, A&A, 410, L37). These observations were carried out on projected baselines ranging from 8 to 112 m in length, using either two 0.35 m siderostats or two 8-m Unit Telescopes. These observations cover the November 2001-January 2004 period. Conclusions: .The reported visibility data are in satisfactory agreement with the recent results obtained with AMBER/VLTI by Weigelt et al. (2006), asuming that the flux of η Car encircled within 70 mas reaches 56% of the total flux within 1400 mas, in the K band. We also confirm that the squared visibility curve of η Car as a function of spatial frequency follows closely an exponential model. Table 1 is only available in electronic form at http://www.aanda.org

Near-infrared interferometry of η Carinae with spectral resolutions of 1 500 and 12 000 using AMBER/VLTI

NASA Astrophysics Data System (ADS)

Weigelt, G.; Kraus, S.; Driebe, T.; Petrov, R. G.; Hofmann, K.-H.; Millour, F.; Chesneau, O.; Schertl, D.; Malbet, F.; Hillier, J. D.; Gull, T.; Davidson, K.; Domiciano de Souza, A.; Antonelli, P.; Beckmann, U.; Bresson, Y.; Chelli, A.; Dugué, M.; Duvert, G.; Gennari, S.; Glück, L.; Kern, P.; Lagarde, S.; Le Coarer, E.; Lisi, F.; Perraut, K.; Puget, P.; Rantakyrö, F.; Robbe-Dubois, S.; Roussel, A.; Tatulli, E.; Zins, G.; Accardo, M.; Acke, B.; Agabi, K.; Altariba, E.; Arezki, B.; Aristidi, E.; Baffa, C.; Behrend, J.; Blöcker, T.; Bonhomme, S.; Busoni, S.; Cassaing, F.; Clausse, J.-M.; Colin, J.; Connot, C.; Delboulbé, A.; Feautrier, P.; Ferruzzi, D.; Forveille, T.; Fossat, E.; Foy, R.; Fraix-Burnet, D.; Gallardo, A.; Giani, E.; Gil, C.; Glentzlin, A.; Heiden, M.; Heininger, M.; Hernandez Utrera, O.; Kamm, D.; Kiekebusch, M.; Le Contel, D.; Le Contel, J.-M.; Lesourd, T.; Lopez, B.; Lopez, M.; Magnard, Y.; Marconi, A.; Mars, G.; Martinot-Lagarde, G.; Mathias, P.; Mège, P.; Monin, J.-L.; Mouillet, D.; Mourard, D.; Nussbaum, E.; Ohnaka, K.; Pacheco, J.; Perrier, C.; Rabbia, Y.; Rebattu, S.; Reynaud, F.; Richichi, A.; Robini, A.; Sacchettini, M.; Schöller, M.; Solscheid, W.; Spang, A.; Stee, P.; Stefanini, P.; Tallon, M.; Tallon-Bosc, I.; Tasso, D.; Testi, L.; Vakili, F.; von der Lühe, O.; Valtier, J.-C.; Vannier, M.; Ventura, N.; Weis, K.; Wittkowski, M.

2007-03-01

Aims: We present the first NIR spectro-interferometry of the LBV η Carinae. The observations were performed with the AMBER instrument of the ESO Very Large Telescope Interferometer (VLTI) using baselines from 42 to 89 m. The aim of this work is to study the wavelength dependence of η Car's optically thick wind region with a high spatial resolution of 5 mas (11 AU) and high spectral resolution. Methods: The observations were carried out with three 8.2 m Unit Telescopes in the K-band. The raw data are spectrally dispersed interferograms obtained with spectral resolutions of 1500 (MR-K mode) and 12 000 (HR-K mode). The MR-K observations were performed in the wavelength range around both the He I 2.059 μm and the Brγ 2.166 μm emission lines, the HR-K observations only in the Brγ line region. Results: The spectrally dispersed AMBER interferograms allow the investigation of the wavelength dependence of the visibility, differential phase, and closure phase of η Car. In the K-band continuum, a diameter of 4.0±0.2 mas (Gaussian FWHM, fit range 28-89 m baseline length) was measured for η Car's optically thick wind region. If we fit Hillier et al. (2001, ApJ, 553, 837) model visibilities to the observed AMBER visibilities, we obtain 50% encircled-energy diameters of 4.2, 6.5 and 9.6 mas in the 2.17 μm continuum, the He I, and the Brγ emission lines, respectively. In the continuum near the Brγ line, an elongation along a position angle of 120°±15° was found, consistent with previous VINCI/VLTI measurements by van Boekel et al. (2003, A&A, 410, L37). We compare the measured visibilities with predictions of the radiative transfer model of Hillier et al. (2001), finding good agreement. Furthermore, we discuss the detectability of the hypothetical hot binary companion. For the interpretation of the non-zero differential and closure phases measured within the Brγ line, we present a simple geometric model of an inclined, latitude-dependent wind zone. Our observations support theoretical models of anisotropic winds from fast-rotating, luminous hot stars with enhanced high-velocity mass loss near the polar regions. Based on observations collected at the European Southern Observatory, Paranal, Chile, within the AMBER guaranteed time programme 074.A-9025 and the VLTI science demonstration programme 074.A-9024.

Milli-arcsecond images of the Herbig Ae star HD 163296

NASA Astrophysics Data System (ADS)

Renard, S.; Malbet, F.; Benisty, M.; Thiébaut, E.; Berger, J.-P.

2010-09-01

Context. The very close environments of young stars are the hosts of fundamental physical processes, such as planet formation, star-disk interactions, mass accretion, and ejection. The complex morphological structure of these environments has been confirmed by the now quite rich data sets obtained for a few objects by near-infrared long-baseline interferometry. Aims: We gathered numerous interferometric measurements for the young star HD 163296 with various interferometers (VLTI, IOTA, KeckI and CHARA), allowing for the first time an image independent of any a priori model to be reconstructed. Methods: Using the Multi-aperture image Reconstruction Algorithm (MiRA), we reconstruct images of HD 163296 in the H and K bands. We compare these images with reconstructed images obtained from simulated data using a physical model of the environment of HD 163296. Results: We obtain model-independent H and K-band images of the surroundings of HD 163296. The images detect several significant features that we can relate to an inclined asymmetric flared disk around HD 163296 with the strongest intensity at about 4-5 mas. Because of the incomplete spatial frequency coverage, we cannot state whether each of them individually is peculiar in any way. Conclusions: For the first time, milli-arcsecond images of the environment of a young star are produced. These images confirm that the morphology of the close environment of young stars is more complex than the simple models used in the literature so far.

Rejuvenation of a ten-year old AO curvature sensor: combining obsolescence correction and performance upgrade of MACAO

NASA Astrophysics Data System (ADS)

Haguenauer, P.; Fedrigo, E.; Pettazzi, L.; Reinero, C.; Gonte, F.; Pallanca, L.; Frahm, R.; Woillez, J.; Lilley, P.

2016-07-01

The MACAO curvature wavefront sensors have been designed as a generic adaptive optics sensor for the Very Large Telescope. Six systems have been manufactured and implemented on sky: four installed in the UTs Coudé train as an AO facility for the VLTI, and two in UT's instruments, SINFONI and CRIRES. The MACAO-VLTI have now been in use for scientific operation for more than a decade and are planned to be operated for at least ten more years. As second generation instruments for the VLTI were planned to start implementation in end of 2015, accompanied with a major upgrade of the VLTI infrastructure, we saw it as a good time for a rejuvenation project of these systems, correcting the obsolete components. This obsolescence correction also gave us the opportunity to implement improved capabilities: the correction frequency was pushed from 420 Hz to 1050 Hz, and an automatic vibrations compensation algorithm was added. The implementation on the first MACAO was done in October 2014 and the first phase of obsolescence correction was completed in all four MACAO-VLTI systems in October 2015 with the systems delivered back to operation. The resuming of the scientific operation of the VLTI on the UTs in November 2015 allowed to gather statistics in order to evaluate the improvement of the performances through this upgrade. A second phase of obsolescence correction has now been started, together with a global reflection on possible further improvements to secure observations with the VLTI.

The Dynamic Atmospheres of Carbon Rich Giants: Constraining Models Via Interferometry

NASA Astrophysics Data System (ADS)

Rau, Gioia; Hron, Josef; Paladini, Claudia; Aringer, Bernard; Eriksson, Kjell; Marigo, Paola

2016-07-01

Dynamic models for the atmospheres of C-rich Asymptotic Giant Branch stars are quite advanced and have been overall successful in reproducing spectroscopic and photometric observations. Interferometry provides independent information and is thus an important technique to study the atmospheric stratification and to further constrain the dynamic models. We observed a sample of six C-rich AGBs with the mid infrared interferometer VLTI/MIDI. These observations, combined with photometric and spectroscopic data from the literature, are compared with synthetic observables derived from dynamic model atmospheres (DMA, Eriksson et al. 2014). The SEDs can be reasonably well modelled and the interferometry supports the extended and multi-component structure of the atmospheres, but some differences remain. We discuss the possible reasons for these differences and we compare the stellar parameters derived from this comparison with stellar evolution models. Finally, we point out the high potential of MATISSE, the second generation VLTI instrument allowing interferometric imaging in the L, M, and N bands, for further progress in this field.

A study of dust properties in the inner sub-au region of the Herbig Ae star HD 169142 with VLTI/PIONIER

NASA Astrophysics Data System (ADS)

Chen, L.; Kóspál, Á.; Ábrahám, P.; Kreplin, A.; Matter, A.; Weigelt, G.

2018-01-01

Context. An essential step to understanding protoplanetary evolution is the study of disks that contain gaps or inner holes. The pre-transitional disk around the Herbig star HD 169142 exhibits multi-gap disk structure, differentiated gas and dust distribution, planet candidates, and near-infrared fading in the past decades, which make it a valuable target for a case study of disk evolution. Aims: Using near-infrared interferometric observations with VLTI/PIONIER, we aim to study the dust properties in the inner sub-au region of the disk in the years 2011-2013, when the object is already in its near-infrared faint state. Methods: We first performed simple geometric modeling to characterize the size and shape of the NIR-emitting region. We then performed Monte-Carlo radiative transfer simulations on grids of models and compared the model predictions with the interferometric and photometric observations. Results: We find that the observations are consistent with optically thin gray dust lying at Rin 0.07 au, passively heated to T 1500 K. Models with sub-micron optically thin dust are excluded because such dust will be heated to much higher temperatures at similar distance. The observations can also be reproduced with a model consisting of optically thick dust at Rin 0.06 au, but this model is plausible only if refractory dust species enduring 2400 K exist in the inner disk. Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere under ESO programs 190.C-963 and 087.C-0709.

VLTI First Fringes with Two Auxiliary Telescopes at Paranal

NASA Astrophysics Data System (ADS)

2005-03-01

World's Largest Interferometer with Moving Optical Telescopes on Track Summary The Very Large Telescope Interferometer (VLTI) at Paranal Observatory has just seen another extension of its already impressive capabilities by combining interferometrically the light from two relocatable 1.8-m Auxiliary Telescopes. Following the installation of the first Auxiliary Telescope (AT) in January 2004 (see ESO PR 01/04), the second AT arrived at the VLT platform by the end of 2004. Shortly thereafter, during the night of February 2 to 3, 2005, the two high-tech telescopes teamed up and quickly succeeded in performing interferometric observations. This achievement heralds an era of new scientific discoveries. Both Auxiliary Telescopes will be offered from October 1, 2005 to the community of astronomers for routine observations, together with the MIDI instrument. By the end of 2006, Paranal will be home to four operational ATs that may be placed at 30 different positions and thus be combined in a very large number of ways ("baselines"). This will enable the VLTI to operate with enormous flexibility and, in particular, to obtain extremely detailed (sharp) images of celestial objects - ultimately with a resolution that corresponds to detecting an astronaut on the Moon. PR Photo 07a/05: Paranal Observing Platform with AT1 and AT2 PR Photo 07b/05: AT1 and AT2 with Open Domes PR Photo 07c/05: Evening at Paranal with AT1 and AT2 PR Photo 07d/05: AT1 and AT2 under the Southern Sky PR Photo 07e/05: First Fringes with AT1 and AT2 PR Video Clip 01/05: Two ATs at Paranal (Extract from ESO Newsreel 15) A Most Advanced Device ESO PR Video 01/05 ESO PR Video 01/05 Two Auxiliary Telescopes at Paranal [QuickTime: 160 x 120 pix - 37Mb - 4:30 min] [QuickTime: 320 x 240 pix - 64Mb - 4:30 min] ESO PR Photo 07a/05 ESO PR Photo 07a/05 [Preview - JPEG: 493 x400 pix - 44k] [Normal - JPEG: 985 x 800 pix - 727k] [HiRes - JPEG: 5000 x 4060 pix - 13.8M] Captions: ESO PR Video Clip 01/05 is an extract from ESO Video Newsreel 15, released on March 14, 2005. It provides an introduction to the VLT Interferometer (VLTI) and the two Auxiliary Telescopes (ATs) now installed at Paranal. ESO PR Photo 07a/05 shows the impressive ensemble at the summit of Paranal. From left to right, the enclosure of VLT Antu, Kueyen and Melipal, AT1, the VLT Survey Telescope (VST) in the background, AT2 and VLT Yepun. Located at the summit of the 2,600-m high Cerro Paranal in the Atacama Desert (Chile), ESO's Very Large Telescope (VLT) is at the forefront of astronomical technology and is one of the premier facilities in the world for optical and near-infrared observations. The VLT is composed of four 8.2-m Unit Telescope (Antu, Kueyen, Melipal and Yepun). They have been progressively put into service together with a vast suite of the most advanced astronomical instruments and are operated every night in the year. Contrary to other large astronomical telescopes, the VLT was designed from the beginning with the use of interferometry as a major goal. The href="/instruments/vlti">VLT Interferometer (VLTI) combines starlight captured by two 8.2- VLT Unit Telescopes, dramatically increasing the spatial resolution and showing fine details of a large variety of celestial objects. The VLTI is arguably the world's most advanced optical device of this type. It has already demonstrated its powerful capabilities by addressing several key scientific issues, such as determining the size and the shape of a variety of stars (ESO PR 22/02, PR 14/03 and PR 31/03), measuring distances to stars (ESO PR 25/04), probing the innermost regions of the proto-planetary discs around young stars (ESO PR 27/04) or making the first detection by infrared interferometry of an extragalactic object (ESO PR 17/03). "Little Brothers" ESO PR Photo 07b/05 ESO PR Photo 07b/05 [Preview - JPEG: 597 x 400 pix - 47k] [Normal - JPEG: 1193 x 800 pix - 330k] [HiRes - JPEG: 5000 x 3354 pix - 10.0M] ESO PR Photo 07c/05 ESO PR Photo 07c/05 [Preview - JPEG: 537 x 400 pix - 31k] [Normal - JPEG: 1074 x 800 pix - 555k] [HiRes - JPEG: 3000 x 2235 pix - 6.0M] ESO PR Photo 07d/05 ESO PR Photo 07d/05 [Preview - JPEG: 400 x 550 pix - 60k] [Normal - JPEG: 800 x 1099 pix - 946k] [HiRes - JPEG: 2414 x 3316 pix - 11.0M] Captions: ESO PR Photo 07b/05 shows VLTI Auxiliary Telescopes 1 and 2 (AT1 and AT2) in the early evening light, with the spherical domes opened and ready for observations. In ESO PR Photo 07c/05, the same scene is repeated later in the evening, with three of the large telescope enclosures in the background. This photo and ESO PR Photo 07c/05 which is a time-exposure with AT1 and AT2 under the beautiful night sky with the southern Milky Way band were obtained by ESO staff member Frédéric Gomté. However, most of the time the large telescopes are used for other research purposes. They are therefore only available for interferometric observations during a limited number of nights every year. Thus, in order to exploit the VLTI each night and to achieve the full potential of this unique setup, some other (smaller), dedicated telescopes were included into the overall VLT concept. These telescopes, known as the VLTI Auxiliary Telescopes (ATs), are mounted on tracks and can be placed at precisely defined "parking" observing positions on the observatory platform. From these positions, their light beams are fed into the same common focal point via a complex system of reflecting mirrors mounted in an underground system of tunnels. The Auxiliary Telescopes are real technological jewels. They are placed in ultra-compact enclosures, complete with all necessary electronics, an air conditioning system and cooling liquid for thermal control, compressed air for enclosure seals, a hydraulic plant for opening the dome shells, etc. Each AT is also fitted with a transporter that lifts the telescope and relocates it from one station to another. It moves around with its own housing on the top of Paranal, almost like a snail. Moreover, these moving ultra-high precision telescopes, each weighing 33 tonnes, fulfill very stringent mechanical stability requirements: "The telescopes are unique in the world", says Bertrand Koehler, the VLTI AT Project Manager. "After being relocated to a new position, the telescope is repositioned to a precision better than one tenth of a millimetre - that is, the size of a human hair! The image of the star is stabilized to better than thirty milli-arcsec - this is how we would see an object of the same size as one of the VLT enclosures on the Moon. Finally, the path followed by the light inside the telescope after bouncing on ten mirrors is stable to better than a few nanometres, which is the size of about one hundred atoms." A World Premiere ESO PR Photo 07e/05 ESO PR Photo 07e/05 "First Fringes" with two ATs [Preview - JPEG: 400 x 559 pix - 61k] [Normal - JPEG: 800 x 1134 pix - 357k] Caption: ESO PR Photo 07e/05 The "First Fringes" obtained with the first two VLTI Auxiliary Telescopes, as seen on the computer screen during the observation. The fringe pattern arises when the light beams from the two 1.8-m telescopes are brought together inside the VINCI instrument. The pattern itself contains information about the angular extension of the observed object, here the 6th-magnitude star HD62082. The fringes are acquired by moving a mirror back and forth around the position of equal path length for the two telescopes. One such scan can be seen in the third row window. This pattern results from the raw interferometric signals (the last two rows) after calibration and filtering using the photometric signals (the 4th and 5th row). The first two rows show the spectrum of the fringe pattern signal. More details about the interpretation of this pattern is given in Appendix A of PR 06/01. The possibility to move the ATs around and thus to perform observations with a large number of different telescope configurations ensures a great degree of flexibility, unique for an optical interferometric installation of this size and crucial for its exceptional performance. The ATs may be placed at 30 different positions and thus be combined in a very large number of ways. If the 8.2-m VLT Unit Telescopes are also taken into account, no less than 254 independent pairings of two telescopes ("baselines"), different in length and/or orientation, are available. Moreover, while the largest possible distance between two 8.2-m telescopes (ANTU and YEPUN) is about 130 metres, the maximal distance between two ATs may reach 200 metres. As the achievable image sharpness increases with telescope separation, interferometric observations with the ATs positioned at the extreme positions will therefore yield sharper images than is possible by combining light from the large telescopes alone. All of this will enable the VLTI to obtain exceedingly detailed (sharp) and very complete images of celestial objects - ultimately with a resolution that corresponds to detecting an astronaut on the Moon. Auxiliary Telescope no. 1 (AT1) was installed on the observatory's platform in January 2004. Now, one year later, the second of the four to be delivered, has been integrated into the VLTI. The installation period lasted two months and ended around midnight during the night of February 2-3, 2005. With extensive experience from the installation of AT1, the team of engineers and astronomers were able to combine the light from the two Auxiliary Telescopes in a very short time. In fact, following the necessary preparations, it took them only five minutes to adjust this extremely complex optical system and successfully capture the "First Fringes" with the VINCI test instrument! The star which was observed is named HD62082 and is just at the limit of what can be observed with the unaided eye (its visual magnitude is 6.2). The fringes were as clear as ever, and the VLTI control system kept them stable for more than one hour. Four nights later this exercise was repeated successfully with the mid-infrared science instrument MIDI. Fringes on the star Alphard (Alpha Hydrae) were acquired on February 7 at 4:05 local time. For Roberto Gilmozzi, Director of ESO's La Silla Paranal Observatory, "this is a very important new milestone. The introduction of the Auxiliary Telescopes in the development of the VLT Interferometer will bring interferometry out of the specialist experiment and into the domain of common user instrumentation for every astronomer in Europe. Without doubt, it will enormously increase the potentiality of the VLTI." With two more telescopes to be delivered within a year to the Paranal Observatory, ESO cements its position as world-leader in ground-based optical astronomy, providing Europe's scientists with the tools they need to stay at the forefront in this exciting science. The VLT Interferometer will, for example, allow astronomers to study details on the surface of stars or to probe proto-planetary discs and other objects for which ultra-high precision imaging is required. It is premature to speculate on what the Very Large Telescope Interferometer will soon discover, but it is easy to imagine that there may be quite some surprises in store for all of us.

An Overview of the Mid-Infrared Spectro-Interferometer MATISSE: Science, Concept, and Current Status

NASA Technical Reports Server (NTRS)

Matter, A.; Lopez, B.; Antonelli, P.; Lehmitz, M.; Bettonvil, F.; Beckmann, U.; Lagarde, S.; Jaffe, W.; Petrov, R. G.; Berio, P.;

Tulip-form variable-curvature mirrors: interferometry and field compensation

NASA Astrophysics Data System (ADS)

Lemaitre, Gerard R.; Mazzanti, Silvio; Ferrari, Marc

1998-07-01

Active Optics methods are now capable to provide variable curvature mirrors (VCMs) having controlled sags in the focal range from f/(infinity) to f/2.5. Those development have been carried out by the authors for the optical path equalizer dedicated to each Mersenne focus of the VLTI. The basic principle is to use VCMs as cat's eye mirrors in each delay line in order to achieve field compensations at the recombined Mersenne focii. During the VLTI development phase, cycloid form VCMs controlled by air pressure have been performed with a 10(superscript -4) mirror sag resolution. The cycloid form has been selected for the VLTi delay lines. However, other analytical solutions from circular plates elasticity theory have been found. Two thickness distributions lead to tulip form VCMs controlled by a central force. One of them, using a lineic reaction at the edge is the object of this paper. Active optics design, construction features, test and experimental He-Ne interferograms obtained with 16mm boundary aperture and 10mm clear aperture are presented. The mean aspect-ratio of the tulip from VCM is d/t(subscript 0.5) approximately equals 60, providing a focal zoom range from f/(infinity) to f/2.5. The experiment is carried out form f/(infinity) to f/5.

The geometry of the close environment of SV Piscium as probed by VLTI/MIDI

NASA Astrophysics Data System (ADS)

Klotz, D.; Sacuto, S.; Kerschbaum, F.; Paladini, C.; Olofsson, H.; Hron, J.

2012-05-01

Context. SV Psc is an asymptotic giant branch (AGB) star surrounded by an oxygen-rich dust envelope. The mm-CO line profile of the object's outflow shows a clear double-component structure. Because of the high angular resolution, mid-IR interferometry may give strong constraints on the origin of this composite profile. Aims: The aim of this work is to investigate the morphology of the environment around SV Psc using high-angular resolution interferometry observations in the mid-IR with the Very Large Telescope MID-infrared Interferometric instrument (VLTI/MIDI). Methods: Interferometric data in the N-band taken at different baseline lengths (ranging from 32-64 m) and position angles (73-142°) allow a study of the morphology of the circumstellar environment close to the star. The data are interpreted on the basis of 2-dimensional, chromatic geometrical models using the fitting software tool GEM-FIND developed for this purpose. Results: The results favor two scenarios: (i) the presence of a highly inclined, optically thin, dusty disk surrounding the central star; (ii) the presence of an unresolved binary companion at a separation of 13.7+4.2-4.8 AU and a position angle of 121.8°+15.4°-24.5° NE. The derived orbital period of the binary is 38.1+20.4-22.6 yr. This detection is in good agreement with hydrodynamic simulations showing that a close companion could be responsible for the entrainment of the gas and dust into a circumbinary structure. Based on observations made with ESO telescopes at La Silla Paranal Observatory under program IDs 082.D-0389 and 086.D-0069.

The Era After the ELT: Optical Interferometry With Kilometer Baselines

NASA Astrophysics Data System (ADS)

Bakker, Eric J.

2007-12-01

The 8-meter class telescopes seen first light in 1993-1998 (Keck, 1993, VLT 1998). The ELT will see first light in the 2013-2018 time frame. The follow-up of the ELT will see first light around 2023. That is 15 years from today. The sequence from 8-meter to 30 meter telescopes (started as a goal of 100m), will suggest a follow-up telescope with an aperture of 300 meter as initial goal. Cleary a 300 meter or more ambitiously a 1000-meter telescope can no longer be structural one piece that has to point to any point on the sky and track the objects. The more likely scenario is to follow the process applied in radio astronomy and move from single telescopes to interferometers. Optical interferometry is maturing very quickly with the de-commissioning of experimental instruments (COAST, GT2I, IOTA, and probably PTI and ISI in the near future) and the use of precision mechanics and automation. The remaining interferometers are grouped in three categories: large telescopes (VLTI and KECK-I), mid-size interferometers (MROI) and small interferometers (CHARA and NPOI). The Magdalena Ridge Observatory Interferometer (MROI) is scheduled for first light/fringe in 2009 and will provide unique observing capabilities to astronomers with limiting magnitudes in the same range as those currently achieved by Keck-I and VLTI. The Magdalena Ridge Observatory Interferometer (near Socorro, NM) invites interested engineers, scientists, and astronomers to participate in the construction and science program of MRO at all levels. Ranging from visitors instruments, support of large procurements in return for access, to individual contributions related to the science program, shared risk observations, etc. For more information, contact the Project Manager at the Magdalena Ridge Observatory Interferometer.

Atlas of low-mass young stellar object disks from mid-infrared interferometry

NASA Astrophysics Data System (ADS)

Varga, J.; Ábrahám, P.; Ratzka, Th.; Menu, J.; Gabányi, K.; Kóspál, Á.; van Boekel, R.; Mosoni, L.; Henning, Th.

We present our approach of visibility modeling of disks around low-mass (< 2 M ⊙) young stellar objects (YSOs). We compiled an atlas based on mid-infrared interferometric observations from the MIDI instrument at the VLTI. We use three different models to fit the data. These models allow us to determine overall sizes (and the extent of the inner gaps) of the modeled circumstellar disks.

New Imaging Operation Scheme at VLTI

NASA Astrophysics Data System (ADS)

Haubois, Xavier

2018-04-01

After PIONIER and GRAVITY, MATISSE will soon complete the set of 4 telescope beam combiners at VLTI. Together with recent developments in the image reconstruction algorithms, the VLTI aims to develop its operation scheme to allow optimized and adaptive UV plane coverage. The combination of spectro-imaging instruments, optimized operation framework and image reconstruction algorithms should lead to an increase of the reliability and quantity of the interferometric images. In this contribution, I will present the status of this new scheme as well as possible synergies with other instruments.

Evaluation of performance of the MACAO systems at the VLTI

NASA Astrophysics Data System (ADS)

Rengaswamy, Sridharan; Haguenauer, Pierre; Brillant, Stephane; Cortes, Angela; Girard, Julien H.; Guisard, Stephane; Paufique, Jérôme; Pino, Andres

2010-07-01

Multiple Application Curvature Adaptive Optics (MACAO) systems are used at the coudé focus of the unit telescopes (UTs) at the La-Silla Paranal Observatory, Paranal, to correct for the wave-front aberrations induced by the atmosphere. These systems are in operation since 2005 and are designed to provide beams with 10 mas residual rms tip-tilt error to the VLTI laboratory. We have initiated several technical studies such as measuring the Strehl ratio of the images recorded at the guiding camera of the VLTI, establishing the optimum setup of the MACAO to get collimated and focused beam down to the VLTI laboratory and to the instruments, and ascertaining the data generated by the real time computer, all aimed at characterizing and improving the overall performance of these systems. In this paper we report the current status of these studies.

The path towards high-contrast imaging with the VLTI: the Hi-5 project

NASA Astrophysics Data System (ADS)

Defrère, D.; Absil, O.; Berger, J.-P.; Boulet, T.; Danchi, W. C.; Ertel, S.; Gallenne, A.; Hénault, F.; Hinz, P.; Huby, E.; Ireland, M.; Kraus, S.; Labadie, L.; Le Bouquin, J.-B.; Martin, G.; Matter, A.; Mérand, A.; Mennesson, B.; Minardi, S.; Monnier, J. D.; Norris, B.; de Xivry, G. Orban; Pedretti, E.; Pott, J.-U.; Reggiani, M.; Serabyn, E.; Surdej, J.; Tristram, K. R. W.; Woillez, J.

2018-06-01

The development of high-contrast capabilities has long been recognized as one of the top priorities for the VLTI. As of today, the VLTI routinely achieves contrasts of a few 10- 3 in the near-infrared with PIONIER (H band) and GRAVITY (K band). Nulling interferometers in the northern hemisphere and non-redundant aperture masking experiments have, however, demonstrated that contrasts of at least a few 10- 4 are within reach using specific beam combination and data acquisition techniques. In this paper, we explore the possibility to reach similar or higher contrasts on the VLTI. After reviewing the state-of-the-art in high-contrast infrared interferometry, we discuss key features that made the success of other high-contrast interferometric instruments (e.g., integrated optics, nulling, closure phase, and statistical data reduction) and address possible avenues to improve the contrast of the VLTI by at least one order of magnitude. In particular, we discuss the possibility to use integrated optics, proven in the near-infrared, in the thermal near-infrared (L and M bands, 3-5 μm), a sweet spot to image and characterize young extra-solar planetary systems. Finally, we address the science cases of a high-contrast VLTI imaging instrument and focus particularly on exoplanet science (young exoplanets, planet formation, and exozodiacal disks), stellar physics (fundamental parameters and multiplicity), and extragalactic astrophysics (active galactic nuclei and fundamental constants). Synergies and scientific preparation for other potential future instruments such as the Planet Formation Imager are also briefly discussed. This project is called Hi-5 for High-contrast Interferometry up to 5 μm.

Hundred metre virtual telescope captures unique detailed colour image

NASA Astrophysics Data System (ADS)

2009-02-01

A team of French astronomers has captured one of the sharpest colour images ever made. They observed the star T Leporis, which appears, on the sky, as small as a two-storey house on the Moon [1]. The image was taken with ESO's Very Large Telescope Interferometer (VLTI), emulating a virtual telescope about 100 metres across and reveals a spherical molecular shell around an aged star. ESO PR Photo 06a/09 The star T Leporis as seen with VLTI ESO PR Photo 06b/09 The star T Leporis to scale ESO PR Photo 06c/09 A virtual 100-metre telescope ESO PR Photo 06d/09 The orbit of Theta1 Orionis C ESO PR Video 06a/09 Zoom-in onto T Leporis "This is one of the first images made using near-infrared interferometry," says lead author Jean-Baptiste Le Bouquin. Interferometry is a technique that combines the light from several telescopes, resulting in a vision as sharp as that of a giant telescope with a diameter equal to the largest separation between the telescopes used. Achieving this requires the VLTI system components to be positioned to an accuracy of a fraction of a micrometre over about 100 metres and maintained so throughout the observations -- a formidable technical challenge. When doing interferometry, astronomers must often content themselves with fringes, the characteristic pattern of dark and bright lines produced when two beams of light combine, from which they can model the physical properties of the object studied. But, if an object is observed on several runs with different combinations and configurations of telescopes, it is possible to put these results together to reconstruct an image of the object. This is what has now been done with ESO's VLTI, using the 1.8-metre Auxiliary Telescopes. "We were able to construct an amazing image, and reveal the onion-like structure of the atmosphere of a giant star at a late stage of its life for the first time," says Antoine Mérand, member of the team. "Numerical models and indirect data have allowed us to imagine the appearance of the star before, but it is quite astounding that we can now see it, and in colour." Although it is only 15 by 15 pixel across, the reconstructed image shows an extreme close-up of a star 100 times larger than the Sun, a diameter corresponding roughly to the distance between the Earth and the Sun. This star is, in turn, surrounded by a sphere of molecular gas, which is about three times as large again. T Leporis, in the constellation of Lepus (the Hare), is located 500 light-years away. It belongs to the family of Mira stars, well known to amateur astronomers. These are giant variable stars that have almost extinguished their nuclear fuel and are losing mass. They are nearing the end of their lives as stars, and will soon die, becoming white dwarfs. The Sun will become a Mira star in a few billion years, engulfing the Earth in the dust and gas expelled in its final throes. Mira stars are among the biggest factories of molecules and dust in the Universe, and T Leporis is no exception. It pulsates with a period of 380 days and loses the equivalent of the Earth's mass every year. Since the molecules and dust are formed in the layers of atmosphere surrounding the central star, astronomers would like to be able to see these layers. But this is no easy task, given that the stars themselves are so far away -- despite their huge intrinsic size, their apparent radius on the sky can be just half a millionth that of the Sun. "T Leporis looks so small from the Earth that only an interferometric facility, such as the VLTI at Paranal, can take an image of it. VLTI can resolve stars 15 times smaller than those resolved by the Hubble Space Telescope," says Le Bouquin. To create this image with the VLTI astronomers had to observe the star for several consecutive nights, using all the four movable 1.8-metre VLT Auxiliary Telescopes (ATs). The ATs were combined in different groups of three, and were also moved to different positions, creating more new interferometric configurations, so that astronomers could emulate a virtual telescope approximately 100 metres across and build up an image. "Obtaining images like these was one of the main motivations for building the Very Large Telescope Interferometer. We have now truly entered the era of stellar imaging," says Mérand. A perfect illustration of this is another VLTI image showing the double star system Theta1 Orionis C in the Orion Nebula Trapezium. This image, which was the first ever constructed from VLTI data, separates clearly the two young, massive stars from this system. The observations themselves have a spatial resolution of about 2 milli-arcseconds. From these, and several other observations, the team of astronomers, led by Stefan Kraus and Gerd Weigelt from the Max-Planck Institute in Bonn, could derive the properties of the orbit of this binary system, including the total mass of the two stars (47 solar masses) and their distance from us (1350 light-years).

Improving the astrometric performance of VLTI-PRIMA

NASA Astrophysics Data System (ADS)

Woillez, J.; Abuter, R.; Andolfato, L.; Berger, J.-P.; Bonnet, H.; Delplancke, F.; Derie, F.; Di Lieto, N.; Guniat, S.; Mérand, A.; Duc, T. Phan; Schmid, C.; Schuhler, N.; Henning, T.; Launhardt, R.; Pepe, F.; Queloz, D.; Quirrenbach, A.; Reffert, S.; Sahlmann, J.; Segransan, D.

2014-07-01

In the summer of 2011, the first on-sky astrometric commissioning of PRIMA-Astrometry delivered a performance of 3 m″ for a 10 ″ separation on bright objects, orders of magnitude away from its exoplanet requirement of 50 μ″ ~ 20 μ″ on objects as faint as 11 mag ~ 13 mag in K band. This contribution focuses on upgrades and characterizations carried out since then. The astrometric metrology was extended from the Coudé focus of the Auxillary Telescopes to their secondary mirror, in order to reduce the baseline instabilities and improve the astrometric performance. While carrying out this extension, it was realized that the polarization retardance of the star separator derotator had a major impact on both the astrometric metrology and the fringe sensors. A local compensation of this retardance and the operation on a symmetric baseline allowed a new astrometric commissioning. In October 2013, an improved astrometric performance of 160 μ″ was demonstrated, still short of the requirements. Instabilities in the astrometric baseline still appear to be the dominating factor. In preparation to a review held in January 2014, a plan was developed to further improve the astrometric and faint target performance of PRIMA Astrometry. On the astrometric aspect, it involved the extension of the internal longitudinal metrology to primary space, the design and implementation of an external baseline metrology, and the development of an astrometric internal fringes mode. On the faint target aspect, investigations of the performance of the fringe sensor units and the development of an AO system (NAOMI) were in the plan. Following this review, ESO decided to take a proposal to the April 2014 STC that PRIMA be cancelled, and that ESO resources be concentrated on ensuring that Gravity and Matisse are a success. This proposal was recommended by the STC in May 2014, and endorsed by ESO.

Little Brother Joins the Large Family

NASA Astrophysics Data System (ADS)

2006-12-01

On the night of 15 December 2006, the fourth and last-to-be-installed VLTI Auxiliary Telescope (AT4) obtained its 'First Light'. The first images demonstrate that AT4 will be able to deliver the excellent image quality already delivered by the first three ATs. It will soon join its siblings to perform routinely interferometric measurements. ESO PR Photo 51a/06 ESO PR Photo 51a/06 VLT Auxiliary Telescope The VLT is composed of four 8.2-m Unit Telescope (Antu, Kueyen, Melipal and Yepun). They have been progressively put into service together with a vast suite of the most advanced astronomical instruments and are operated every night in the year. Contrary to other large astronomical telescopes, the VLT was designed from the beginning with the use of interferometry as a major goal. The VLT Interferometer (VLTI) combines starlight captured by two or three 8.2- VLT Unit Telescopes, dramatically increasing the spatial resolution and showing fine details of a large variety of celestial objects. ESO PR Photo 51b/06 ESO PR Photo 51b/06 One AT Under the Sky However, most of the time the large telescopes are used for other research purposes. They are therefore only available for interferometric observations during a limited number of nights every year. Thus, in order to exploit the VLTI each night and to achieve the full potential of this unique setup, some other (smaller), dedicated telescopes were included into the overall VLT concept. These telescopes, known as the VLTI Auxiliary Telescopes (ATs), are mounted on tracks and can be placed at precisely defined "parking" observing positions on the observatory platform. From these positions, their light beams are fed into the same common focal point via a complex system of reflecting mirrors mounted in an underground system of tunnels. The Auxiliary Telescopes are real technological jewels. They are placed in ultra-compact enclosures, complete with all necessary electronics, an air conditioning system and cooling liquid for thermal control, compressed air for enclosure seals, a hydraulic plant for opening the dome shells, etc. Each AT is also fitted with a transporter that lifts the telescope and relocates it from one station to another. It moves around with its own housing on the top of Paranal, almost like a snail. The VLTI is arguably the world's most advanced optical device of this type. It has already demonstrated its powerful capabilities by addressing several key scientific issues, such as determining the size and the shape of a variety of stars (ESO PR 22/02, PR 14/03, PR 31/03, and PR 09/06), measuring distances to stars (ESO PR 25/04), probing the innermost regions of the proto-planetary discs around young stars (ESO PR 27/04 and PR 35/06) or making the first detection by infrared interferometry of an extragalactic object (ESO PR 17/03).

With the VLT Interferometer towards Sharper Vision

NASA Astrophysics Data System (ADS)

2000-05-01

The Nova-ESO VLTI Expertise Centre Opens in Leiden (The Netherlands) European science and technology will gain further strength when the new, front-line Nova-ESO VLTI Expertise Centre (NEVEC) opens in Leiden (The Netherlands) this week. It is a joint venture of the Netherlands Research School for Astronomy (NOVA) (itself a collaboration between the Universities of Amsterdam, Groningen, Leiden, and Utrecht) and the European Southern Observatory (ESO). It is concerned with the Very Large Telescope Interferometer (VLTI). The Inauguration of the new Centre will take place on Friday, May 26, 2000, at the Gorlaeus Laboratory (Lecture Hall no. 1), Einsteinweg 55 2333 CC Leiden; the programme is available on the web. Media representatives who would like to participate in this event and who want further details should contact the Nova Information Centre (e-mail: jacques@astro.uva.nl; Tel: +31-20-5257480 or +31-6-246 525 46). The inaugural ceremony is preceded by a scientific workshop on ground and space-based optical interferometry. NEVEC: A Technology Centre of Excellence As a joint project of NOVA and ESO, NEVEC will develop in the coming years the expertise to exploit the unique interferometric possibilities of the Very Large Telescope (VLT) - now being built on Paranal mountain in Chile. Its primary goals are the * development of instrument modeling, data reduction and calibration techniques for the VLTI; * accumulation of expertise relevant for second-generation VLTI instruments; and * education in the use of the VLTI and related matters. NEVEC will develop optical equipment, simulations and software to enable interferometry with VLT [1]. The new Center provides a strong impulse to Dutch participation in the VLTI. With direct involvement in this R&D work, the scientists at NOVA will be in the front row to do observations with this unique research facility, bound to produce top-level research and many exciting new discoveries. The ESO VLTI at Paranal ESO PR Photo 14a/00 ESO PR Photo 14a/00 [Preview - JPEG: 359 x 400 pix - 120k] [Normal - JPEG: 717 x 800 pix - 416k] [High-Res - JPEG: 2689 x 3000 pix - 6.7M] Caption : A view of the Paranal platform with the four 8.2-m VLT Unit Telescopes (UTs) and the foundations for the 1.8-m VLT Auxiliary Telescopes (ATs) that together will be used as the VLT Interferometer (VLTI). The three ATs will move on rails (yet to be installed) between the thirty observing stations above the holes that provide access to the underlying tunnel system. The light beams from the individual telescopes will be guided towards the centrally located, partly underground Interferometry Laboratory in which the VLTI instruments will be set up. This photo was obtained in December 1999 at which time some construction materials were still present on the platform; they were electronically removed in this reproduction. The ESO VLT facility at Paranal (Chile) consists of four Unit Telescopes with 8.2-m mirrors and several 1.8-m auxiliary telescopes that move on rails, cf. PR Photo 14a/00 . While each of the large telescopes can be used individually for astronomical observations, a prime feature of the VLT is the possibility to combine all of these telescopes into the Very Large Telescope Interferometer (VLTI) . In the interferometric mode, the light beams from the VLT telescopes are brought together at a common focal point in the Interferometry Laboratory that is placed at the centre of the observing platform on top of Paranal. In principle, this can be done in such a way that the resulting (reconstructed) image appears to come from a virtual telescope with a diameter that is equal to the largest distance between two of the individual telescopes, i.e., up to about 200 metres. The theoretically achievable image sharpness of an astronomical telescope is proportional to its diameter (or, for an interferometer, the largest distance between two of its component telescopes). The interferometric observing technique will thus allow the VLTI to produce images as sharp as 0.001 arcsec (at wavelength 1 µm) - this corresponds to viewing the shape of a golfball at more than 8,000 km distance. The VLTI will do even better when this technique is later extended to shorter wavelengths in the visible part of the spectrum - it may ultimately distinguish human-size objects on the surface of the Moon (a 2-metre object at this distance, about 400,000 km, subtends an angle of about 0.001 arcsec). However, interferometry with the VLT demands that the wavefronts of light from the individual telescopes that are up to 200 meters apart must be matched exactly, with less than 1 wavelength of difference. This demands continuous mechanical stability to a fraction of 1 µm (0.001 mm) for the heavy components over such large distances, and is a technically formidable challenge. This is achieved by electronic feed-back loops that measure and adjust the distances during the observations. In addition, continuous and automatic correction of image distortions from air turbulence in the telescopes' field of view is performed by means of adaptive optics [2]. VLTI technology at ESO, industry and institutes The VLT Interferometer is based on front-line technologies introduced and advanced by ESO, and its many parts are now being constructed at various sites in Europe. ESO PR Photo 14b/00 ESO PR Photo 14b/00 [Preview - JPEG: 359 x 400 pix - 72k] [Normal - JPEG: 717 x 800 pix - 200k] [High-Res - JPEG: 2687 x 3000 pix - 1.3M] Caption : Schematic lay-out of the VLT Interferometer. The light from a distant celestial objects enters two of the VLT telescopes and is reflected by the various mirrors into the Interferometric Tunnel, below the observing platform on the top of Paranal. Two Delay Lines with moveable carriages continuously adjust the length of the paths so that the two beams interfere constructively and produce fringes at the interferometric focus in the laboratory. In 1998, Fokker Space (also in Leiden, The Netherlands) was awarded a contract for the delivery of the three Delay Lines of the VLTI. This mechanical-optical system will compensate the optical path differences of the light beams from the individual telescopes. It is necessary to ensure that the light from all telescopes arrives in the same phase at the focal point of the interferometer. Otherwise, the very sharp interferometric images cannot be obtained. More details are available in the corresponding ESO PR 04/98 and recent video sequences, included in ESO Video News Reel No. 9 and Video Clip 04a/00 , cf. below. Also in 1998, the company AMOS (Liège, Belgium) was awarded an ESO contract for the delivery of the three 1.8-m Auxiliary Telescopes (ATs) and of the full set of on-site equipment for the 30 AT observing stations, cf. ESO PR Photos 25a-b/98. This work is now in progress at the factory - various scenes are incorporated into ESO Video News Reel No. 9 and Video Clip 04b/00 . Several instruments for imaging and spectroscopy are currently being developed for the VLTI. The first will be the VLT Interferometer Commissioning Instrument (VINCI) that is the test and first-light instrument for the VLT Interferometer. It is being built by a consortium of French and German institutes under ESO contract. The VLTI Near-Infrared / Red Focal Instrument (AMBER) is a collaborative project between five institutes in France, Germany and Italy, under ESO contract. It will operate with two 8.2-m UTs in the wavelength range between 1 and 2.5 µm during a first phase (2001-2003). The wavelength coverage will be extended in a second phase down to 0.6 µm (600 nm) at the time the ATs become operational. Main scientific objectives are the investigation at very high-angular resolution of disks and jets around young stellar objects and dust tori at active galaxy nuclei with spectroscopic observations. The Phase-Referenced Imaging and Microarcsecond Astrometry (PRIMA) device is managed by ESO and will allow simultaneous interferometric observations of two objects - each with a maximum size of 2 arcsec - and provide exceedingly accurate positional measurements. This will be of importance for many different kinds of astronomical investigations, for instance the search for planetary companions by means of accurate astrometry. The MID-Infrared interferometric instrument (MIDI) is a project collaboration between eight institutes in France, Germany and the Netherlands [1], under ESO contract. The actual design of MIDI is optimized for operation at 10 µm and a possible extension to 20 µm is being considered. Notes [1] The NEVEC Centre is involved in the MIDI project for the VLTI. Another joint project between ESO and NOVA is the Wide-Field Imager OMEGACAM for the VLT Survey Telescope (VST) that will be placed at Paranal. [2] Adaptive Optics systems allow to continuously "re-focus" an astronomical telescope in order to compensate for the atmospheric turbulence and thus to obtain the sharpest possible images. The work at ESO is described on the Adaptive Optics Team Homepage. VLTI-related videos now available In conjunction with the Inauguration of the NEVEC Centre (Leiden, The Netherlands) on May 26, 2000, ESO has issued ESO Video News Reel No. 9 (May 2000) ( "The Sharpest Vision - Interferometry with the VLT" ). Tapes with this VNR, suitable for transmission and in full professional quality (Betacam, etc.), are now available for broadcasters upon request; please contact the ESO EPR Department for more details. Extracts from this VNR are available as ESO Video Clips 04a/00 and 04b/00 . ESO PR Video Clip 04a/00 [160x120 pix MPEG-version] ESO PR Video Clip 04a/00 (2600 frames/1:44 min) [MPEG Video+Audio; 160x120 pix; 2.4Mb] [MPEG Video+Audio; 320x240 pix; 4.8 Mb] [RealMedia; streaming; 33kps] [RealMedia; streaming; 200kps] ESO Video Clip 04a/00 shows some recent tests with the prototype VLT Delay Line carriage at FOKKER Space (Leiden, The Netherlands. This device is crucial for the proper functioning of the VLTI and will be mounted in the main interferometric tunnel at Paranal. Contents: Outside view of the FOKKER site. The carriage on rails. The protecting cover is removed. View towards the cat's eye. The carriage moves on the rails. ESO PR Video Clip 04b/00 [160x120 pix MPEG-version] ESO PR Video Clip 04b/00 (3425 frames/2:17 min) [MPEG Video+Audio; 160x120 pix; 3.2Mb] [MPEG Video+Audio; 320x240 pix; 6.3 Mb] [RealMedia; streaming; 33kps] [RealMedia; streaming; 200kps] ESO Video Clip 04b/00 shows the construction of the 1.8-m VLT Auxiliary Telescopes at AMOS (Liège, Belgium). Contents: External view of the facility. Computer drawing of the mechanics. The 1.8-m mirror (graphics). Construction of the centerpiece of the telescope tube. Mechanical parts. Checking the optical shape of an 1.8-m mirror. Mirror cell with supports for the 1.8-m mirror. Test ramp with rails on which the telescope moves and an "observing station" (the hole). The telescope yoke that will support the telescope tube. Both clips are available in four versions: two MPEG files and two streamer-versions of different sizes; the latter require RealPlayer software. They may be freely reproduced if ESO is mentioned as source. Most of the ESO PR Video Clips at the ESO website provide "animated" illustrations of the ongoing work and events at the European Southern Observatory. The most recent clip was: ESO PR Video Clip 03/00 with a trailer for "Physics on Stage" (2 May 2000). Information is also available on the web about other ESO videos.

On the Brγ line emission of the Herbig Ae/Be star MWC 120

NASA Astrophysics Data System (ADS)

Kreplin, Alexander; Tambovtseva, Larisa; Grinin, Vladimir; Kraus, Stefan; Weigelt, Gerd; Wang, Yang

2018-06-01

The origin of the Br γ line in Herbig Ae/Be stars is still an open question. It has been proposed that a fraction of the 2.166-μm Br γ emission might emerge from a disc wind, the magnetosphere and other regions. Investigations of the Br γ line in young stellar objects are important to improve our understanding of the accretion-ejection process. Near-infrared long-baseline interferometry enables the investigation of the Br γ line-emitting region with high spatial and high spectral resolution. We observed the Herbig Ae/Be star MWC 120 with the Astronomical Multi-Beam Recombiner (AMBER) on the Very Large Telescope Interferometer (VLTI) in different spectral channels across the Br γ line with a spectral resolution of R ˜ 1500. Comparison of the visibilities, differential and closure phases in the continuum and the line-emitting region with geometric and radiative transfer disc-wind models leads to constraints on the origin and dynamics of the gas emitting the Br γ light. Geometric modelling of the visibilities reveals a line-emission region about two times smaller than the K-band continuum region, which indicates a scenario where the Br γ emission is dominated by an extended disc wind rather than by a much more compact magnetospheric origin. To compare our data with a physical model, we applied a state-of-the-art radiative transfer disc-wind model. We find that all measured visibilities, differential and closure phases of MWC 120 can be approximately reproduced by a disc-wind model. A comparison with other Herbig stars indicates a correlation of the modelled inner disc-wind radii with the corresponding Alfvén radii for late spectral type stars.

Generic control software connecting astronomical instruments to the reflective memory data recording system of VLTI - bossvlti

NASA Astrophysics Data System (ADS)

Pozna, E.; Ramirez, A.; Mérand, A.; Mueller, A.; Abuter, R.; Frahm, R.; Morel, S.; Schmid, C.; Duc, T. Phan; Delplancke-Ströbele, F.

2014-07-01

The quality of data obtained by VLTI instruments may be refined by analyzing the continuous data supplied by the Reflective Memory Network (RMN). Based on 5 years experience providing VLTI instruments (PACMAN, AMBER, MIDI) with RMN data, the procedure has been generalized to make the synchronization with observation trouble-free. The present software interface saves not only months of efforts for each instrument but also provides the benefits of software frameworks. Recent applications (GRAVITY, MATISSE) supply feedback for the software to evolve. The paper highlights the way common features been identified to be able to offer reusable code in due course.

The wind of the M-type AGB star RT Virginis probed by VLTI/MIDI

NASA Astrophysics Data System (ADS)

Sacuto, S.; Ramstedt, S.; Höfner, S.; Olofsson, H.; Bladh, S.; Eriksson, K.; Aringer, B.; Klotz, D.; Maercker, M.

2013-03-01

Aims: We study the circumstellar environment of the M-type AGB star RT Vir using mid-infrared high spatial resolution observations from the ESO-VLTI focal instrument MIDI. The aim of this study is to provide observational constraints on theoretical prediction that the winds of M-type AGB objects can be driven by photon scattering on iron-free silicate grains located in the close environment (about 2 to 3 stellar radii) of the star. Methods: We interpreted spectro-interferometric data, first using wavelength-dependent geometric models. We then used a self-consistent dynamic model atmosphere containing a time-dependent description of grain growth for pure forsterite dust particles to reproduce the photometric, spectrometric, and interferometric measurements of RT Vir. Since the hydrodynamic computation needs stellar parameters as input, a considerable effort was first made to determine these parameters. Results: MIDI differential phases reveal the presence of an asymmetry in the stellar vicinity. Results from the geometrical modeling give us clues to the presence of aluminum and silicate dust in the close circumstellar environment (<5 stellar radii). Comparison between spectro-interferometric data and a self-consistent dust-driven wind model reveals that silicate dust has to be present in the region between 2 to 3 stellar radii to reproduce the 59 and 63 m baseline visibility measurements around 9.8 μm. This gives additional observational evidence in favor of winds driven by photon scattering on iron-free silicate grains located in the close vicinity of an M-type star. However, other sources of opacity are clearly missing to reproduce the 10-13 μm visibility measurements for all baselines. Conclusions: This study is a first attempt to understand the wind mechanism of M-type AGB stars by comparing photometric, spectrometric, and interferometric measurements with state-of-the-art, self-consistent dust-driven wind models. The agreement of the dynamic model atmosphere with interferometric measurements in the 8-10 μm spectral region gives additional observational evidence that the winds of M-type stars can be driven by photon scattering on iron-free silicate grains. Finally, a larger statistical study and progress in advanced self-consistent 3D modeling are still required to solve the remaining problems. Based on observations made with the Very Large Telescope Interferometer at Paranal Observatory under programs 083.D-0234 and 086.D-0737 (Open Time Observations).

Beating the confusion limit: the necessity of high angular resolution for probing the physics of Sagittarius A* and its environment: opportunities for LINC-NIRVANA (LBT), GRAVITY (VLTI) and and METIS (E-ELT)

NASA Astrophysics Data System (ADS)

Eckart, A.; Sabha, N.; Witzel, G.; Straubmeier, C.; Shahzamanian, B.; Valencia-S., M.; García-Marín, Macarena; Horrobin, M.; Moser, L.; Zuther, J.; Fischer, S.; Rauch, C.; Rost, S.; Iserlohe, C.; Yazici, S.; Smajic, S.; Wiest, M.; Araujo-Hauck, C.; Wank, I.

2012-07-01

The super-massive 4 million solar mass black hole (SMBH) SgrA* shows variable emission from the millimeter to the X-ray domain. A detailed analysis of the infrared light curves allows us to address the accretion phenomenon in a statistical way. The analysis shows that the near-infrared flux density excursions are dominated by a single state power law, with the low states of SgrA* are limited by confusion through the unresolved stellar background. We show that for 8-10m class telescopes blending effects along the line of sight will result in artificial compact star-like objects of 0.5-1 mJy that last for about 3-4 years. We discuss how the imaging capabilities of GRAVITY at the VLTI, LINC-NIRVANA at the LBT and METIS at the E-ELT will contribute to the investigation of the low variability states of SgrA*.

Structure of Herbig AeBe disks at the milliarcsecond scale . A statistical survey in the H band using PIONIER-VLTI

NASA Astrophysics Data System (ADS)

Lazareff, B.; Berger, J.-P.; Kluska, J.; Le Bouquin, J.-B.; Benisty, M.; Malbet, F.; Koen, C.; Pinte, C.; Thi, W.-F.; Absil, O.; Baron, F.; Delboulbé, A.; Duvert, G.; Isella, A.; Jocou, L.; Juhasz, A.; Kraus, S.; Lachaume, R.; Ménard, F.; Millan-Gabet, R.; Monnier, J. D.; Moulin, T.; Perraut, K.; Rochat, S.; Soulez, F.; Tallon, M.; Thiébaut, E.; Traub, W.; Zins, G.

2017-03-01

Context. It is now generally accepted that the near-infrared excess of Herbig AeBe stars originates in the dust of a circumstellar disk. Aims: The aims of this article are to infer the radial and vertical structure of these disks at scales of order 1 au, and the properties of the dust grains. Methods: The program objects (51 in total) were observed with the H-band (1.6 μm) PIONIER/VLTI interferometer. The largest baselines allowed us to resolve (at least partially) structures of a few tenths of an au at typical distances of a few hundred parsecs. Dedicated UBVRIJHK photometric measurements were also obtained. Spectral and 2D geometrical parameters are extracted via fits of a few simple models: ellipsoids and broadened rings with azimuthal modulation. Model bias is mitigated by parallel fits of physical disk models. Sample statistics were evaluated against similar statistics for the physical disk models to infer properties of the sample objects as a group. Results: We find that dust at the inner rim of the disk has a sublimation temperature Tsub ≈ 1800 K. A ring morphology is confirmed for approximately half the resolved objects; these rings are wide δr/r ≥ 0.5. A wide ring favors a rim that, on the star-facing side, looks more like a knife edge than a doughnut. The data are also compatible with the combination of a narrow ring and an inner disk of unspecified nature inside the dust sublimation radius. The disk inner part has a thickness z/r ≈ 0.2, flaring to z/r ≈ 0.5 in the outer part. We confirm the known luminosity-radius relation; a simple physical model is consistent with both the mean luminosity-radius relation and the ring relative width; however, a significant spread around the mean relation is present. In some of the objects we find a halo component, fully resolved at the shortest interferometer spacing, that is related to the HAeBe class. Full Tables B1-B3, as well as results of other parametric fits, are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/599/A85 The calibrated interferometric data can be found as FITS format files at http://oidb.jmmc.fr/collection.html?id=HAeBeLP

First Optical observation of a microquasar at sub-milliarsec scale: SS 433 resolved by VLTI/GRAVITY

NASA Astrophysics Data System (ADS)

Petrucci, P.; Waisberg, I.; Lebouquin, J.; Dexter, J.; Dubus, G.; Perraut, K.; Kervella, P.; Gravity Collaboration

2017-10-01

We present the first Optical observation at sub-milliarcsec (mas) scale of the famous microquasar SS 433 obtained with the GRAVITY instrument on the VLTI interferometer. This observation reveals the SS 433 inner regions with unprecedent details: The K-band continuum emitting region is dominated by a marginally resolved point source (< 1 mas) embedded inside a diffuse background accounting for 10% of the total flux. The significant visibility drop across the jet lines present in the K-band spectrum, together with the small and nearly identical phases for all baselines, point toward a jet that is offset by < 0.5 mas from the continuum source and resolved in the direction of propagation, with a size of ˜2 mas. Jet emission so close to the central binary system implies that line locking, if relevant to explain the 0.26c jet velocity, operates on elements heavier than hydrogen. Concerning The Brγ line, it is better resolved than the continuum and the S-shape phase signal present across the line suggests an East-West oriented geometry alike the jet direction and supporting a (polar) disk wind origin. This observation show the potentiality of Optical interferometry to constrain the inner regions of high energy sources like microquasars.

VLTI/AMBER spectro-interferometric imaging of VX Sagittarii's inhomogenous outer atmosphere

NASA Astrophysics Data System (ADS)

Chiavassa, A.; Lacour, S.; Millour, F.; Driebe, T.; Wittkowski, M.; Plez, B.; Thiébaut, E.; Josselin, E.; Freytag, B.; Scholz, M.; Haubois, X.

2010-02-01

Aims: We aim to explore the photosphere of the very cool late-type star VX Sgr and in particular the characterization of molecular layers above the continuum forming photosphere. Methods: We obtained interferometric observations with the VLTI/AMBER interferometer using the fringe tracker FINITO in the spectral domain 1.45-2.50 μm with a spectral resolution of ≈35 and baselines ranging from 15 to 88 m. We performed independent image reconstruction for different wavelength bins and fit the interferometric data with a geometrical toy model. We also compared the data to 1D dynamical models of Miras atmosphere and to 3D hydrodynamical simulations of red supergiant (RSG) and asymptotic giant branch (AGB) stars. Results: Reconstructed images and visibilities show a strong wavelength dependence. The H-band images display two bright spots whose positions are confirmed by the geometrical toy model. The inhomogeneities are qualitatively predicted by 3D simulations. At ≈2.00 μm and in the region 2.35-2.50 μm, the photosphere appears extended and the radius is larger than in the H band. In this spectral region, the geometrical toy model locates a third bright spot outside the photosphere that can be a feature of the molecular layers. The wavelength dependence of the visibility can be qualitatively explained by 1D dynamical models of Mira atmospheres. The best-fitting photospheric models show a good match with the observed visibilities and give a photospheric diameter of Theta=8.82 ± 0.50 mas. The H2O molecule seems to be the dominant absorber in the molecular layers. Conclusions: We show that the atmosphere of VX Sgr seems to resemble Mira/AGB star model atmospheres more closely than do RSG model atmospheres. In particular, we see molecular (water) layers that are typical of Mira stars. Based on the observations made with VLTI-ESO Paranal, Chile under the programs IDs 081.D-0005(A, B, C, D, E, F, G, H).

Polinsar Experiments of Multi-Mode X-Band Data Over South Area of China

NASA Astrophysics Data System (ADS)

Lu, L.; Yan, Q.; Duan, M.; Zhang, Y.

2012-08-01

This paper makes the polarimetric and polarimetric interferometric synthetic aperture radar (PolInSAR) experiments with the high-resolution X-band data acquired by Multi-mode airborne SAR system over an area around Linshui, south of China containing tropic vegetation and urban areas. Polarimetric analysis for typical tropic vegetations and man-made objects are presented, some polarimetric descriptors sensitive to vegetations and man-made objects are selected. Then, the PolInSAR information contained in the data is investigated, considering characteristics of the Multi-mode-XSAR dataset, a dual-baseline polarimetric interferometry method is proposed in this paper. The method both guarantees the high coherence on fully polarimetric data and combines the benefits of short and long baseline that helpful to the phase unwrapping and height sensitivity promotion. PolInSAR experiment results displayed demonstrates Multi-mode-XSAR datasets have intuitive capabilities for amount of application of land classification, objects detection and DSM mapping.

Observations of Young Stellar Objects with Infrared Interferometry: Recent Results from PTI, KI and IOTA

NASA Astrophysics Data System (ADS)

Akeson, Rachel

Young stellar objects have been one of the favorite targets of infrared interferometers for many years. In this contribution I will briefly review some of the first results and their contributions to the field and then describe some of the recent results from the Keck Interferometer (KI), the Palomar Testbed Interferometer (PTI) and the Infrared-Optical Telescope Array (IOTA). This conference also saw many exciting new results from the VLTI at both near and mid-infrared wavelengths that are covered by other contributions.

Optimization of a Turboprop UAV for Maximum Loiter and Specific Power Using Genetic Algorithm

NASA Astrophysics Data System (ADS)

Dinc, Ali

2016-09-01

In this study, a genuine code was developed for optimization of selected parameters of a turboprop engine for an unmanned aerial vehicle (UAV) by employing elitist genetic algorithm. First, preliminary sizing of a UAV and its turboprop engine was done, by the code in a given mission profile. Secondly, single and multi-objective optimization were done for selected engine parameters to maximize loiter duration of UAV or specific power of engine or both. In single objective optimization, as first case, UAV loiter time was improved with an increase of 17.5% from baseline in given boundaries or constraints of compressor pressure ratio and burner exit temperature. In second case, specific power was enhanced by 12.3% from baseline. In multi-objective optimization case, where previous two objectives are considered together, loiter time and specific power were increased by 14.2% and 9.7% from baseline respectively, for the same constraints.

Direct Observation of Hot Jupiters and Other Faint Companions with the VLTI

NASA Astrophysics Data System (ADS)

Coudé du Foresto, Vincent

The existence of Jupiter-size planets very close to their parent stars (two examples of which are 51 Peg and τ Boo) creates a challenge for theories of planetary formation and structure. Only a direct measurement of their mass and luminosity (not accessible via the current radial velocity techniques) can help discriminate between the different models that have been proposed for this class of objects.

VLT/I Instrumentation: Lessons Learned FORUM

NASA Astrophysics Data System (ADS)

Monnet, G.; Bacon, R.

2003-09-01

This paper is the result of a joint effort by ESO and its Scientific and Technical Committee (STC) to extract the main lessons from last April's 'VLT/VLTI Instrumentation: Lessons learned' Forum and start applying them, in particular in the framework of the development of second generation VLT -and soon VLTI- instruments. This is but one step in a continuing effort to optimize these complex and challenging developments which involve a significant fraction of Europe's astronomical instrument builders in the near-UV to mid-IR range. With a major effort in the European radio community to build multiple receiver systems for ALMA now being pursued at an accelerated pace, it was also vital to revisit very quickly our whole procurement strategy in this area.

AMBER-NACO aperture-synthesis imaging of the half-obscured central star and the edge-on disk of the red giant L2 Puppis

NASA Astrophysics Data System (ADS)

Ohnaka, K.; Schertl, D.; Hofmann, K.-H.; Weigelt, G.

2015-09-01

Aims: The red giant L2 Pup started a dimming event in 1994, which is considered to be caused by the ejection of dust clouds. We present near-IR aperture-synthesis imaging of L2 Pup achieved by combining data from VLT/NACO and the AMBER instrument of the Very Large Telescope Interferometer (VLTI). Our aim is to spatially resolve the innermost region of the circumstellar environment. Methods: We carried out speckle interferometric observations at 2.27 μm with VLT/NACO and long-baseline interferometric observations with VLTI/AMBER at 2.2-2.35 μm with baselines of 15-81 m. We also extracted an 8.7 μm image from the mid-IR VLTI instrument MIDI. Results: The diffraction-limited image obtained by bispectrum speckle interferometry with NACO with a spatial resolution of 57 mas shows an elongated component. The aperture-synthesis imaging combining the NACO speckle data and AMBER data with a spatial resolution of 5.6 × 7.3 mas further resolves not only this elongated component, but also the central star. The reconstructed image reveals that the elongated component is a nearly edge-on disk with a size of ~180 × 50 mas lying in the E-W direction, and furthermore, that the southern hemisphere of the central star is severely obscured by the equatorial dust lane of the disk. The angular size of the disk is consistent with the distance that the dust clouds that were ejected at the onset of the dimming event should have traveled by the time of our observations, if we assume that the dust clouds moved radially. This implies that the formation of the disk may be responsible for the dimming event. The 8.7 μm image with a spatial resolution of 220 mas extracted from the MIDI data taken in 2004 (seven years before the AMBER and NACO observations) shows an approximately spherical envelope without a signature of the disk. This suggests that the mass loss before the dimming event may have been spherical. Based on AMBER, NACO, and MIDI observations made with the Very Large Telescope and Very Large Telescope Interferometer of the European Southern Observatory. Program ID: 074.D-0075(A), 074.D-0101(A), 074.D-0198(B), 088.D-0150(A/B), and 288.D-5041(A). Appendices are available in electronic form at http://www.aanda.org

Recent results from the SIMECA code and VLTI observations

NASA Astrophysics Data System (ADS)

Meilland, A.; Stee, Ph.

We present recent results on active hot stars using the first VLTI/MIDI and VLTI/AMBER observations, and the SIMECA code developed by Stee (1994). α Arae was the first classical Be star observed with MIDI (June 2003) and AMBER (February 2005). The size of its circumstellar envelope was measured and thanks to the spectrally-resolved interferometric AMBER observations, we were able, for the first time to evidence the Keplerian rotation of the circumstellar disc. MWC 297 is one of the brightest Herbig Be star, and it was then observed during the first commissioning run of AMBER in May 2004. The data obtained were good enough to allow us to infer the accretion disc extension, as well as to put strong constraints on the stellar wind geometry and kinematics.

First VLTI/MIDI observations of a Be star: Alpha Arae

NASA Astrophysics Data System (ADS)

Chesneau, O.; Meilland, A.; Rivinius, T.; Stee, Ph.; Jankov, S.; Domiciano de Souza, A.; Graser, U.; Herbst, T.; Janot-Pacheco, E.; Koehler, R.; Leinert, C.; Morel, S.; Paresce, F.; Richichi, A.; Robbe-Dubois, S.

2005-05-01

We present the first VLTI/MIDI observations of the Be star alpha Ara (HD 158 427), showing a nearly unresolved circumstellar disk in the N band. The interferometric measurements made use of the UT1 and UT3 telescopes. The projected baselines were 102 and 74 meters with position angles of 7 ° and 55°, respectively. These measurements put an upper limit on the envelope size in the N band under the uniform disk approximation of φmax= 4±1.5 mas, corresponding to 14 R*, assuming R*=4.8 R⊙ and the Hipparcos distance of 74 pc. On the other hand the disk density must be large enough to produce the observed strong Balmer line emission. In order to estimate the possible circumstellar and stellar parameters we have used the SIMECA code developed by Stee et al. (1995, A&A, 300, 219) and Stee & Bittar (2001, A&A, 367, 532). Optical spectra taken with the échelle instrument Heros and the ESO-50 cm telescope, as well as infrared ones from the 1.6m Brazilian telescope were used together with the MIDI spectra and visibilities. These observations place complementary constraints on the density and geometry of the alpha Ara circumstellar disk. We discuss the potential truncation of the disk by a companion and we present spectroscopic indications of a periodic perturbation of some Balmer lines.

VLTI-PRIMA fringe tracking testbed

NASA Astrophysics Data System (ADS)

Abuter, Roberto; Rabien, Sebastian; Eisenhauer, Frank; Sahlmann, Johannes; Di Lieto, Nicola; Haug, Marcus; Wallander, Anders; Lévêque, Samuel; Ménardi, Serge; Delplancke, Françoise; Schuhler, Nicolas; Kellner, Stefan; Frahm, Robert

2006-06-01

One of the key components of the planned VLTI dual feed facility PRIMA is the Fringe Sensor Unit (FSU). Its basic function is the instantaneous measurement of the Optical Path Difference (OPD) between two beams. The FSU acts as the sensor for a complex control system involving optical delay lines and laser metrology with the aim of removing any OPD introduced by the atmosphere and the beam relay. We have initiated a cooperation between ESO and MPE with the purpose of systematically testing this Fringe Tracking Control System in a laboratory environment. This testbed facility is being built at MPE laboratories with the aim to simulate the VLTI and includes FSUs, OPD controller, metrology and in-house built delay lines. In this article we describe this testbed in detail, including the environmental conditions in the laboratory, and present the results of the testbed subsystem characterisation.

Multi-objective optimization for an automated and simultaneous phase and baseline correction of NMR spectral data

NASA Astrophysics Data System (ADS)

Sawall, Mathias; von Harbou, Erik; Moog, Annekathrin; Behrens, Richard; Schröder, Henning; Simoneau, Joël; Steimers, Ellen; Neymeyr, Klaus

2018-04-01

Spectral data preprocessing is an integral and sometimes inevitable part of chemometric analyses. For Nuclear Magnetic Resonance (NMR) spectra a possible first preprocessing step is a phase correction which is applied to the Fourier transformed free induction decay (FID) signal. This preprocessing step can be followed by a separate baseline correction step. Especially if series of high-resolution spectra are considered, then automated and computationally fast preprocessing routines are desirable. A new method is suggested that applies the phase and the baseline corrections simultaneously in an automated form without manual input, which distinguishes this work from other approaches. The underlying multi-objective optimization or Pareto optimization provides improved results compared to consecutively applied correction steps. The optimization process uses an objective function which applies strong penalty constraints and weaker regularization conditions. The new method includes an approach for the detection of zero baseline regions. The baseline correction uses a modified Whittaker smoother. The functionality of the new method is demonstrated for experimental NMR spectra. The results are verified against gravimetric data. The method is compared to alternative preprocessing tools. Additionally, the simultaneous correction method is compared to a consecutive application of the two correction steps.

Interferometric observation of microlensing events

NASA Astrophysics Data System (ADS)

Cassan, Arnaud; Ranc, Clément

2016-05-01

Interferometric observations of microlensing events have the potential to provide unique constraints on the physical properties of the lensing systems. In this work, we first present a formalism that closely combines interferometric and microlensing observable quantities, which lead us to define an original microlensing (u, v) plane. We run simulations of long-baseline interferometric observations and photometric light curves to decide which observational strategy is required to obtain a precise measurement on vector Einstein radius. We finally perform a detailed analysis of the expected number of targets in the light of new microlensing surveys (2011+) which currently deliver 2000 alerts per year. We find that a few events are already at reach of long-baseline interferometers (CHARA, VLTI), and a rate of about six events per year is expected with a limiting magnitude of K ≃ 10. This number would increase by an order of magnitude by raising it to K ≃ 11. We thus expect that a new route for characterizing microlensing events will be opened by the upcoming generations of interferometers.

High-resolution Interferometric Observations of Nova RS Ophiuchi and a Proposed Unification Model for Persistent Dust Creation in Recurrent Novae

NASA Astrophysics Data System (ADS)

Barry, R. K.; Danchi, W. C.

2008-12-01

We review observations of nova RS Ophiuchi using long-baseline near-infrared and mid-infrared interferometry at three observatories: the Keck Interferometer in the Nulling mode (KIN), the Palomar Testbed Interferometer (PTI), and the Infrared and Optical Telescope Array (IOTA). We discuss these observations in the context of a unifying model of the system that includes an increase in density in the plane of the orbit of the two stars created by a spiral shock wave caused by the motion of the stars through the cool wind of the red giant star. We discuss how recent observations using the Spitzer Space Telescope and the VLTI support this proposed model.

Baseline process description for simulating plutonium oxide production for precalc project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pike, J. A.

Savannah River National Laboratory (SRNL) started a multi-year project, the PreCalc Project, to develop a computational simulation of a plutonium oxide (PuO 2) production facility with the objective to study the fundamental relationships between morphological and physicochemical properties. This report provides a detailed baseline process description to be used by SRNL personnel and collaborators to facilitate the initial design and construction of the simulation. The PreCalc Project team selected the HB-Line Plutonium Finishing Facility as the basis for a nominal baseline process since the facility is operational and significant model validation data can be obtained. The process boundary as wellmore » as process and facility design details necessary for multi-scale, multi-physics models are provided.« less

Lunar Occultations, Setting the Stage for VLTI: The Case Study of CW-Leo (aka IRC+10216)

NASA Astrophysics Data System (ADS)

Käufl, Hans Ulrich; Stecklum, Bringfried; Richter, Steffen; Richichi, Andrea

Lunar occultation allows for a sneak preview of what the VLTI will observe, both with comparable angular resolution and sensitivity. In the thermal infrared ( λ ≈ 10μ m, angular resolution ≤ 0.03^' ') the technique has been pioneered with TIMMI on La Silla. Using this technique several dust shells around Asymptotic Giant Branch stars have been resolved. For the Carbon star CW-Leo (IRC+10 216) high S/N scans will allow for `11/2-dimensional' imaging of the source. At the present state of data reduction the light curves already provide for a very convincing proof of theories on the milli-arcsec scale. In combination with VLTI the technique allows for checks of the visibility calibration and related issues. Moreover, in the (u,v)-plane both techniques are extremely complementary, so that a merging of the data sets appear highly desirable. At La Silla and Paranal ESO a suite of instruments which can be (ab)used for this project is under construction.

Planet Formation in Action? - Astronomers may have found the first object clearing its path in the natal disc surrounding a young star

NASA Astrophysics Data System (ADS)

2011-02-01

Using ESO's Very Large Telescope an international team of astronomers has been able to study the short-lived disc of material around a young star that is in the early stages of making a planetary system. For the first time a smaller companion could be detected that may be the cause of the large gap found in the disc. Future observations will determine whether this companion is a planet or a brown dwarf. Planets form from the discs of material around young stars, but the transition from dust disc to planetary system is rapid and few objects are caught during this phase [1]. One such object is T Chamaeleontis (T Cha), a faint star in the small southern constellation of Chamaeleon that is comparable to the Sun, but very near the beginning of its life [2]. T Cha lies about 350 light-years from the Earth and is only about seven million years old. Up to now no forming planets have been found in these transitional discs, although planets in more mature discs have been seen before (eso0842, heic0821). "Earlier studies had shown that T Cha was an excellent target for studying how planetary systems form," notes Johan Olofsson (Max Planck Institute for Astronomy, Heidelberg, Germany), one of the lead authors of two papers in the journal Astronomy & Astrophysics that describe the new work. "But this star is quite distant and the full power of the Very Large Telescope Interferometer (VLTI) was needed to resolve very fine details and see what is going on in the dust disc." The astronomers first observed T Cha using the AMBER instrument and the VLT Interferometer (VLTI) [3]. They found that some of the disc material formed a narrow dusty ring only about 20 million kilometres from the star. Beyond this inner disc, they found a region devoid of dust with the outer part of the disc stretching out into regions beyond about 1.1 billion kilometres from the star. Nuria Huélamo (Centro de Astrobiología, ESAC, Spain), the lead author of the second paper takes up the story: "For us the gap in the dust disc around T Cha was a smoking gun, and we asked ourselves: could we be witnessing a companion digging a gap inside its protoplanetary disc?" However, finding a faint companion so close to a bright star is a huge challenge and the team had to use the VLT instrument NACO in a novel and powerful way, called sparse aperture masking, to reach their goal [4]. After careful analysis they found the clear signature of an object located within the gap in the dust disc, about one billion kilometres from the star - slightly further out than Jupiter is within our Solar System and close to the outer edge of the gap. This is the first detection of an object much smaller than a star within a gap in the planet-forming dust disc around a young star. The evidence suggests that the companion object cannot be a normal star [5] but it could be either a brown dwarf [6] surrounded by dust or, most excitingly, a recently formed planet. Huélamo concludes: "This is a remarkable joint study that combines two different state-of-the-art instruments at ESO's Paranal Observatory. Future observations will allow us to find out more about the companion and the disc, and also understand what fuels the inner dusty disc." Notes [1] The transitional discs can be spotted because they give off less radiation at mid-infrared wavelengths. The clearing of the dust close to the star and the creation of gaps and holes can explain this missing radiation. Recently formed planets may have created these gaps, although there are also other possibilities. [2] T Cha is a T Tauri star, a very young star that is still contracting towards the main sequence. [3] The astronomers used the AMBER instrument (Astronomical Multi-BEam combineR) and the VLTI to combine the light from all four of the 8.2-metre VLT Unit Telescopes and create a "virtual telescope" 130 metres across. [4] NACO (or NAOS-CONICA in full) is an adaptive optics instrument attached to ESO's Very Large Telescope. Thanks to adaptive optics, astronomers can remove most of the blurring effect of the atmosphere and obtain very sharp images. The team used NACO in a novel way, called sparse aperture masking (SAM) to search for the companion. This is a type of interferometry that, rather than combining the light from multiple telescopes as the VLTI does, uses different parts of the mirror of a single telescope (in this case, the mirror of the VLT Unit Telescope 4). This new technique is particularly good for finding faint objects very close to bright ones. VLTI/AMBER is better suited to studying the structure of the inner disc and is less sensitive to the presence of a distant companion. [5] The astronomers searched for the companion using NACO in two different spectral bands - at around 2.2 microns and at 3.8 microns. The companion is only seen at the longer wavelength, which means that the object is either cool, like a planet, or a dust-shrouded brown dwarf. [6] Brown dwarfs are objects between stars and planets in size. They are not massive enough to fuse hydrogen in their cores but are larger than giant planets such as Jupiter. More information This research was presented in two papers: Olofsson et al. 2011, "Warm dust resolved in the cold disk around TCha with VLTI/AMBER", and Huélamo et al. 2011, "A companion candidate in the gap of the T Cha transitional disk", to appear in the journal Astronomy & Astrophysics. The team is composed of J. Olofsson (Max-Planck-Institut für Astronomie [MPIA], Heidelberg, Germany), M. Benisty (MPIA), J.-C. Augereau (Institut de Planétologie et d'Astrophysique de Grenoble [IPAG], France) C. Pinte (IPAG), F. Ménard (IPAG), E. Tatulli (IPAG), J.-P. Berger (ESO, Santiago, Chile), F. Malbet (IPAG), B. Merín (Herschel Science Centre, Madrid, Spain), E. F. van Dishoeck (Leiden University, Holland), S. Lacour (Observatoire de Paris, France), K. M. Pontoppidan (California Institute of Technology, USA), J.-L. Monin (IPAG), J. M. Brown (Max-Planck-Institut für extraterrestrische Physik, Garching, Germany), G. A. Blake (California Institute of Technology), N. Huélamo (Centro de Astrobiología, ESAC, Spain), P. Tuthill (University of Sydney, Australia), M. Ireland (University of Sydney), A. Kraus (University of Hawaii) and G. Chauvin (Université Joseph Fourier, Grenoble, France). ESO, the European Southern Observatory, is the foremost intergovernmental astronomy organisation in Europe and the world's most productive astronomical observatory. It is supported by 15 countries: Austria, Belgium, Brazil, the Czech Republic, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. ESO carries out an ambitious programme focused on the design, construction and operation of powerful ground-based observing facilities enabling astronomers to make important scientific discoveries. ESO also plays a leading role in promoting and organising cooperation in astronomical research. ESO operates three unique world-class observing sites in Chile: La Silla, Paranal and Chajnantor. At Paranal, ESO operates the Very Large Telescope, the world's most advanced visible-light astronomical observatory and VISTA, the world's largest survey telescope. ESO is the European partner of a revolutionary astronomical telescope ALMA, the largest astronomical project in existence. ESO is currently planning a 42-metre European Extremely Large optical/near-infrared Telescope, the E-ELT, which will become "the world's biggest eye on the sky".

Assessing the quality of restored images in optical long-baseline interferometry

NASA Astrophysics Data System (ADS)

Gomes, Nuno; Garcia, Paulo J. V.; Thiébaut, Éric

2017-03-01

Assessing the quality of aperture synthesis maps is relevant for benchmarking image reconstruction algorithms, for the scientific exploitation of data from optical long-baseline interferometers, and for the design/upgrade of new/existing interferometric imaging facilities. Although metrics have been proposed in these contexts, no systematic study has been conducted on the selection of a robust metric for quality assessment. This article addresses the question: what is the best metric to assess the quality of a reconstructed image? It starts by considering several metrics and selecting a few based on general properties. Then, a variety of image reconstruction cases are considered. The observational scenarios are phase closure and phase referencing at the Very Large Telescope Interferometer (VLTI), for a combination of two, three, four and six telescopes. End-to-end image reconstruction is accomplished with the MIRA software, and several merit functions are put to test. It is found that convolution by an effective point spread function is required for proper image quality assessment. The effective angular resolution of the images is superior to naive expectation based on the maximum frequency sampled by the array. This is due to the prior information used in the aperture synthesis algorithm and to the nature of the objects considered. The ℓ1-norm is the most robust of all considered metrics, because being linear it is less sensitive to image smoothing by high regularization levels. For the cases considered, this metric allows the implementation of automatic quality assessment of reconstructed images, with a performance similar to human selection.

Infrared Spectro-Interferometry of Massive Stars: Disks, Winds, Outflows, and Stellar Multiplicity

NASA Astrophysics Data System (ADS)

Kraus, Stefan

2007-06-01

Interferometry is the ultimate technology for overcoming the limitations which diffraction and the atmosphere-induced seeing impose on the resolution achievable with ground-based telescopes. The latest generation of long-baseline interferometric instruments (in particular VLTI/AMBER and VLTI/MIDI), combines the high spatial resolution (typically a few milliarcseconds) with spectroscopic capabilities, allowing one to characterize the geometry of a continuum-emitting region over a wide spectral range or to spatially resolve the emitting region of Doppler-broadened spectral lines in many velocity channels. One branch of astrophysics which might particularly benefit from these advances in technology is the study of massive (O-B type) stars. In order to characterize these stars and their companions and to study accretion and outflow processes in their vicinity with unprecedented angular resolution, we have performed interferometric studies on four key objects, representing the still most enigmatic evolutionary phases of massive stars; namely the pre-main-sequence (MWC 147, NGC 7538 IRS1, Theta 1 Orionis C) and the post-main-sequence phase (Eta Carinae). MWC 147: As indicated by its strong infrared excess, this young Herbig Be star (B6-type) is still associated with residual material from its formation; maybe arranged in a circumstellar disk. In order to investigate the geometry of the material, we combined, for the first time, long-baseline spectro-interferometric observations at near- (NIR) and mid-infrared (MIR) wavelengths (using VLTI/AMBER, VLTI/MIDI, and archival PTI data). Fitting analytic models to the obtained interferometric data revealed a significant elongation of the continuum-emitting region. For a physical interpretation, we modeled the geometry of the dust distribution using 2-D radiative transfer simulations of Keplerian disks with and without a puffed-up inner rim, simultaneously fitting the wavelength-dependent visibilities and the SED, which we complemented with archival Spitzer/IRS spectra. Surprisingly, we found that passive disk models, which can reproduce the SED well, are in strong conflict with the interferometric data. However, when including emission from an optically thick inner gaseous disk, good quantitative agreement was found for all observables, suggesting that MWC 147 harbours a still actively accreting disk. NGC 7538 IRS1/2: NGC 7538 IRS1 is a high-mass (O7-type) protostar with a CO outflow, an associated ultracompact H II region, and a linear methanol maser structure, which might trace a Keplerian-rotating circumstellar disk. We investigated the NIR morphology of the source with unprecedented resolution using NIR bispectrum speckle interferometry obtained at the BTA 6 m and the MMT 6.5 m telescopes. Our high-dynamic range images show fan-shaped outflow structures, in which we detected 18 stars and several blobs of diffuse emission. Complementary archival Spitzer/IRAC images were used to relate the detected structures with the outflow at larger scales. We found a misalignment of various outflow axes and interpreted this in the context of a disk precession model, also using molecular hydrodynamic simulations. As a possible triggering mechanism, we identified non-coplanar tidal interaction of an (yet undiscovered) close companion with the circumbinary disk. Finally, our observations resolved the nearby massive protostar NGC 7538 IRS2 as a close binary with a separation of 195 mas, finding indications for shock interaction between the outflows from IRS1 and IRS2. Theta 1 Orionis C/D: Located in the Orion Trapezium Cluster, Theta 1 C is one of the youngest and nearest high-mass (O5-O7) stars. The star is also known to be a close binary system. We traced the orbital motion from 1997.8 to 2004.8 using visual and NIR bispectrum speckle interferometry at the BTA 6 m telescope. In 2005.9, we obtained first IOTA long-baseline interferometry on the Theta 1 C system, allowing us to derive preliminary solutions for the dynamical orbit and the dynamical mass. Taking the measured flux ratio and the derived location in the HR-diagram into account, we estimated the spectral types and masses of Theta 1 Ori C1 and C2 to be O5.5 (M=34.0 M_sun) and O9.5 (M=15.5 M_sun), respectively. Thus, the companion C2 appears to be much more massive than previously thought, suggesting strong wind-wind interaction during the periastron passage, which we predict for epoch 2007.5 with a small physical separation of only approx. 1.5 AU. From the IOTA data on Theta 1 Ori C, we reconstructed the first optical aperture synthesis image of a young star. We also obtained IOTA data for Theta 1 Ori D, which appears resolved, perhaps indicating the presence of a close, faint companion. Eta Carinae: Using VLTI/AMBER, we performed the first NIR spectro-interferometry of the Luminous Blue Variable (LBV) Eta Car, simultaneously obtaining high spatial and spectral resolutions (R=1,500 and 12,000). The measured wavelength-dependent visibilities, differential phases, and closure phases were used to constrain the geometry of the continuum-emitting region, as well as the Br Gamma 2.166 micron and He I 2.059 micron line-emitting region. We compared the measured visibilities with predictions of the radiative transfer model of Hillier et al. (2001), finding good agreement. For the interpretation of the non-zero differential and closure phases measured within the Br Gamma line, we present a simple geometric model of an inclined, latitude-dependent wind zone. Thus, our observations support theoretical models of anisotropic winds from fast-rotating, luminous hot stars with enhanced high-velocity mass loss near the polar regions. In the He I line, we measured non-zero phases as well, indicating asymmetries in the brightness distribution, which we discuss in the context of wind-wind interaction between Eta Car and its hypothetical hot binary companion. Using simulations, we examined the possibility to directly detect this companion in future observations. Besides these astrophysical results of my dissertation, I present work related to methodological and technical aspects of infrared interferometry. The principles of a data reduction software developed for IOTA/IONIC3 and a pipeline for VLTI/AMBER are discussed. Furthermore, I summarize comparative studies which aim to evaluate the performance of different image reconstruction algorithms in order to explore the prospects and limitations of optical aperture synthesis imaging.

Constraints on observing brightness asymmetries in protoplanetary disks at solar system scale

NASA Astrophysics Data System (ADS)

Brunngräber, Robert; Wolf, Sebastian

2018-04-01

We have quantified the potential capabilities of detecting local brightness asymmetries in circumstellar disks with the Very Large Telescope Interferometer (VLTI) in the mid-infrared wavelength range. The study is motivated by the need to evaluate theoretical models of planet formation by direct observations of protoplanets at early evolutionary stages, when they are still embedded in their host disk. Up to now, only a few embedded candidate protoplanets have been detected with semi-major axes of 20-50 au. Due to the small angular separation from their central star, only long-baseline interferometry provides the angular resolving power to detect disk asymmetries associated to protoplanets at solar system scales in nearby star-forming regions. In particular, infrared observations are crucial to observe scattered stellar radiation and thermal re-emission in the vicinity of embedded companions directly. For this purpose we performed radiative transfer simulations to calculate the thermal re-emission and scattered stellar flux from a protoplanetary disk hosting an embedded companion. Based on that, visibilities and closure phases are calculated to simulate observations with the future beam combiner MATISSE, operating at the L, M and N bands at the VLTI. We find that the flux ratio of the embedded source to the central star can be as low as 0.5 to 0.6% for a detection at a feasible significance level due to the heated dust in the vicinity of the embedded source. Furthermore, we find that the likelihood for detection is highest for sources at intermediate distances r ≈ 2-5 au and disk masses not higher than ≈10-4 M⊙.

VLTI Imaging of a High-Mass Protobinary System: Unveiling the Dynamical Processes in High-Mass Star Formation

NASA Astrophysics Data System (ADS)

Kraus, S.; Kluska, J.; Kreplin, A.; Bate, M.; Harries, T.; Hofmann, K.-H.; Hone, E.; Monnier, J.; Weigelt, G.; Anugu, N.; de Wit, W.-J..; Wittkowski, M.

2017-12-01

High-mass stars exhibit a significantly higher multiplicity frequency than low-mass stars, likely reflecting differences in how they formed. Theory suggests that high-mass binaries may form by the fragmentation of self-gravitational discs or by alternative scenarios such as disc-assisted capture. Near-infrared interferometric observations reveal the high-mass young stellar object IRAS 17216-3801 to be a close high-mass protobinary with a separation of 0.058 arcseconds ( 170 au). This is the closest high-mass protobinary system imaged to date. We also resolve near- infrared excess emission around the individual stars, which is associated with hot dust in circumstellar discs. These discs are strongly misaligned with respect to the binary separation vector, indicating that tidal forces have not yet had time to realign. We measure a higher accretion rate towards the circumsecondary disc, confirming a hydrodynamic effect where the secondary star disrupts the primary star’s accretion stream and effectively limits the mass that the primary star can accrete. NACO L'-band imaging may also have resolved the circumbinary disc that feeds the accretion onto the circumstellar discs. This discovery demonstrates the unique capabilities of the VLTI, creating exciting new opportunities to study the dynamical processes that govern the architecture of close multiple systems.

The beam combiners of Gravity VLTI instrument: concept, development, and performance in laboratory

NASA Astrophysics Data System (ADS)

Jocou, L.; Perraut, K.; Moulin, T.; Magnard, Y.; Labeye, P.; Lapras, V.; Nolot, A.; Perrin, G.; Eisenhauer, F.; Holmes, C.; Amorim, A.; Brandner, W.; Straubmeier, C.

2014-07-01

Gravity is one of the second-generation instruments of the Very Large Telescope Interferometer that operates in the near infrared range and that is designed for precision narrow-angle astrometry and interferometric imaging. With its infrared wavefront sensors, pupil stabilization, fringe tracker, and metrology, the instrument is tailored to provide a high sensitivity, imaging with 4-millisecond resolution, and astrometry with a 10μarcsec precision. It will probe physics close to the event horizon of the Galactic Centre black hole, and allow to study mass accretion and jets in young stellar objects and active galactic nuclei, planet formation in circumstellar discs, or detect and measure the masses of black holes in massive star clusters throughout the Milky Way. As the instrument required an outstanding level of precision and stability, integrated optics has been chosen to collect and combine the four VLTI beams in the K band. A dedicated integrated optics chip glued to a fiber array has been developed. Technology breakthroughs have been mandatory to fulfill all the specifications. This paper is focused on the interferometric beam combination system of Gravity. Once the combiner concept described, the paper details the developments that have been led, the integration and the performance of the assemblies.

Imaging Stellar Surfaces with an Agile 12-Telescopes Visible Interferometer for the VLTI

NASA Astrophysics Data System (ADS)

Woillez, Julien

2018-04-01

Imaging stellar surfaces with an optical interferometer requires a large number of telescopes and the extensive use of the bootstrapping technique to reach the high spatial frequencies where the surface details are revealed. An idea would use all 6 dual-star delay lines of VLTI to deploy an agile 12-telescopes single-mode visible interferometer on the Paranal mountain. The concept relies on single-mode fiber technologies that have been demonstrated by the `OHANA and `OHANA IKI projects. We present the expected performance of this concept and explore its potential for the study of stellar surfaces.

Tori, Discs, and Winds: The First Ten Years of AGN Interferometry

NASA Astrophysics Data System (ADS)

Hönig, Sebastian F.

Infrared (IR) interferometry has made significant progress over the last 10 years to a level that active galactic nuclei (AGN) are now routine targets for long-baseline interferometers. Almost 50 different objects have been studied today in the near-IR and mid-IR. This allowed for detailed characterisation of the dusty environment of the actively growing black holes. It was possible to show directly that the dust must be arranged in clumps, as had been indirectly inferred from theory and unresolved observations. The dust composition seems to undergo significant evolution from galactic scales to the AGN environment, with the hottest dust close to the sublimation front being dominated by large graphite grains. While the overall distribution of the dusty mass is quite diverse from object to object, indications have been found that the dust distribution may depend on AGN luminosity, with more powerful AGN potentially showing more compact dust structures. Arguably the most exciting discovery was the fact that the bulk of the mid-IR emission in Seyfert galaxies emerges from the polar region of the AGN, which is difficult to reconcile with classical torus models. An alternative model is currently being debated that consists of a dusty disc plus a dusty wind driven by radiation pressure from the central source. This finding has major implications for our understanding of AGN unification and will become a focus of the upcoming generation of instruments at the VLTI. More recently, an application of interferometry to cosmology was proposed to measure precise geometric distances to AGN in the Hubble flow. Further exploration of this method may open up interferometry to a new scientific community.

An Interferometric Study of the Post-AGB Binary 89 Herculis. 1: Spatially Resolving the Continuum Circumstellar Environment at Optical and Near-IR Wavelengths with the VLTI, NPOI, IOTA, PTI, and the CHARA Array

DTIC Science & Technology

2013-01-01

evolution of binaries as well as the structure of circumstellar disks. Aims. A multiwavelength high angular resolution study of the prototypical object...optical to mid-IR wave- lengths. For YSOs this has led to the discovery of an empiri- cal size-luminosity relation (Millan-Gabet et al. 2001; Monnier...Millan-Gabet 2002), which in turn has led to the current paradigm (Dullemond & Monnier 2010) of a passive dusty disk with an optically thin cavity and the

AMBER/VLTI and MIDI/VLTI spectro-interferometric observations of the B[e] supergiant CPD-57°2874. Size and geometry of the circumstellar envelope in the near- and mid-IR

NASA Astrophysics Data System (ADS)

Domiciano de Souza, A.; Driebe, T.; Chesneau, O.; Hofmann, K.-H.; Kraus, S.; Miroshnichenko, A. S.; Ohnaka, K.; Petrov, R. G.; Preisbisch, T.; Stee, P.; Weigelt, G.; Lisi, F.; Malbet, F.; Richichi, A.

2007-03-01

We present the first high spatial and spectral resolution observations of the circumstellar envelope (CSE) of a B[e] supergiant (CPD-57°2874), performed with the Very Large Telescope Interferometer (VLTI). Spectra, visibilities and closure phase were obtained using the beam-combiner instruments AMBER (near-IR interferometry with three 8.3 m Unit Telescopes or UTs) and MIDI (mid-IR interferometry with two UTs). The interferometric observations of the CSE are well fitted by an elliptical Gaussian model with FWHM diameters varying linearly with wavelength. Typical diameters measured are ≃1.8×3.4 mas or ≃4.5×8.5 AU (adopting a distance of 2.5 kpc) at 2.2 μm, and ≃12×15 mas or ≃30×38 AU at 12 μm. The size of the region emitting the Brγ flux is ≃2.8×5.2 mas or ≃7.0×13.0 AU. The major-axis position angle of the elongated CSE in the mid-IR (≃144°) agrees well with previous polarimetric data, hinting that the hot-dust emission originates in a disk-like structure. In addition to the interferometric observations we also present new optical (UBVR_cI_c) and near-IR (JHKL) broadband photometric observations of CPD-57°2874. Our spectro-interferometric VLTI observations and data analysis support the non-spherical CSE paradigm for B[e] supergiants. Based on observations collected at the European Southern Observatory, Paranal, Chile, within the AMBER science demonstration time programme 074.A-9026 and the MIDI open time programme 074.D-0101.

Tank waste remediation system multi-year work plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The Tank Waste Remediation System (TWRS) Multi-Year Work Plan (MYWP) documents the detailed total Program baseline and was constructed to guide Program execution. The TWRS MYWP is one of two elements that comprise the TWRS Program Management Plan. The TWRS MYWP fulfills the Hanford Site Management System requirement for a Multi-Year Program Plan and a Fiscal-Year Work Plan. The MYWP addresses program vision, mission, objectives, strategy, functions and requirements, risks, decisions, assumptions, constraints, structure, logic, schedule, resource requirements, and waste generation and disposition. Sections 1 through 6, Section 8, and the appendixes provide program-wide information. Section 7 includes a subsectionmore » for each of the nine program elements that comprise the TWRS Program. The foundation of any program baseline is base planning data (e.g., defendable product definition, logic, schedules, cost estimates, and bases of estimates). The TWRS Program continues to improve base data. As data improve, so will program element planning, integration between program elements, integration outside of the TWRS Program, and the overall quality of the TWRS MYWP. The MYWP establishes the TWRS baseline objectives to store, treat, and immobilize highly radioactive Hanford waste in an environmentally sound, safe, and cost-effective manner. The TWRS Program will complete the baseline mission in 2040 and will incur costs totalling approximately 40 billion dollars. The summary strategy is to meet the above objectives by using a robust systems engineering effort, placing the highest possible priority on safety and environmental protection; encouraging {open_quotes}out sourcing{close_quotes} of the work to the extent practical; and managing significant but limited resources to move toward final disposition of tank wastes, while openly communicating with all interested stakeholders.« less

Tank waste remediation system multi-year work plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1994-09-01

The Tank Waste Remediation System (TWRS) Multi-Year Work Plan (MYWP) documents the detailed total Program baseline and was constructed to guide Program execution. The TWRS MYWP is one of two elements that comprise the TWRS Program Management Plan. The TWRS MYWP fulfills the Hanford Site Management System requirement for a Multi-Year Program Plan and a Fiscal-Year Work Plan. The MYWP addresses program vision, mission, objectives, strategy, functions and requirements, risks, decisions, assumptions, constraints, structure, logic, schedule, resource requirements, and waste generation and disposition. Sections 1 through 6, Section 8, and the appendixes provide program-wide information. Section 7 includes a subsectionmore » for each of the nine program elements that comprise the TWRS Program. The foundation of any program baseline is base planning data (e.g., defendable product definition, logic, schedules, cost estimates, and bases of estimates). The TWRS Program continues to improve base data. As data improve, so will program element planning, integration between program elements, integration outside of the TWRS Program, and the overall quality of the TWRS MYWP. The MYWP establishes the TWRS baseline objectives to store, treat, and immobilize highly radioactive Hanford waste in an environmentally sound, safe, and cost-effective manner. The TWRS Program will complete the baseline mission in 2040 and will incur costs totalling approximately 40 billion dollars. The summary strategy is to meet the above objectives by using a robust systems engineering effort, placing the highest possible priority on safety and environmental protection; encouraging {open_quotes}out sourcing{close_quotes} of the work to the extent practical; and managing significant but limited resources to move toward final disposition of tank wastes, while openly communicating with all interested stakeholders.« less

Habitable Exoplanet Imaging Mission (HabEx): Architecture of the 4m Mission Concept

NASA Astrophysics Data System (ADS)

Kuan, Gary M.; Warfield, Keith R.; Mennesson, Bertrand; Kiessling, Alina; Stahl, H. Philip; Martin, Stefan; Shaklan, Stuart B.; amini, rashied

2018-01-01

The Habitable Exoplanet Imaging Mission (HabEx) study is tasked by NASA to develop a scientifically compelling and technologically feasible exoplanet direct imaging mission concept, with extensive general astrophysics capabilities, for the 2020 Decadal Survey in Astrophysics. The baseline architecture of this space-based observatory concept encompasses an unobscured 4m diameter aperture telescope flying in formation with a 72-meter diameter starshade occulter. This large aperture, ultra-stable observatory concept extends and enhances upon the legacy of the Hubble Space Telescope by allowing us to probe even fainter objects and peer deeper into the Universe in the same ultraviolet, visible, and near infrared wavelengths, and gives us the capability, for the first time, to image and characterize potentially habitable, Earth-sized exoplanets orbiting nearby stars. Revolutionary direct imaging of exoplanets will be undertaken using a high-contrast coronagraph and a starshade imager. General astrophysics science will be undertaken with two world-class instruments – a wide-field workhorse camera for imaging and multi-object grism spectroscopy, and a multi-object, multi-resolution ultraviolet spectrograph. This poster outlines the baseline architecture of the HabEx flagship mission concept.

A mid-IR interferometric survey with MIDI/VLTI: resolving the second-generation protoplanetary disks around post-AGB binaries

NASA Astrophysics Data System (ADS)

Hillen, M.; Van Winckel, H.; Menu, J.; Manick, R.; Debosscher, J.; Min, M.; de Wit, W.-J.; Verhoelst, T.; Kamath, D.; Waters, L. B. F. M.

2017-03-01

Aims: We present a mid-IR interferometric survey of the circumstellar environment of a specific class of post-asymptotic giant branch (post-AGB) binaries. For this class the presence of a compact dusty disk has been postulated on the basis of various spatially unresolved measurements. The aim is to determine the angular extent of the N-band emission directly and to resolve the compact circumstellar structures. Methods: Our interferometric survey was performed with the MIDI instrument on the VLTI. In total 19 different systems were observed using variable baseline configurations. Combining all the visibilities at a single wavelength at 10.7 μm, we fitted two parametric models to the data: a uniform disk and a ring model mimicking a temperature gradient. We compared our observables of the whole sample, with synthetic data computed from a grid of radiative transfer models of passively irradiated disks in hydrostatic equilibrium. These models are computed with a Monte Carlo code that has been widely applied to describe the structure of protoplanetary disks around young stellar objects (YSO). Results: The spatially resolved observations show that the majority of our targets cluster closely together in the distance-independent size-colour diagram, and have extremely compact N-band emission regions. The typical uniform disk diameter of the N-band emission region is 40 mas, which corresponds to a typical brightness temperature of 400-600 K. The resolved objects display very similar characteristics in the interferometric observables and in the spectral energy distributions. Therefore, the physical properties of the disks around our targets must be similar. Our results are discussed in the light of recently published sample studies of YSOs to compare quantitatively the secondary discs around post-AGB stars to the ones around YSOs. Conclusions: Our high-angular-resolution survey further confirms the disk nature of the circumstellar structures present around wide post-AGB binaries. The grid of protoplanetary disk models covers very well the observed objects. Much like for young stars, the spatially resolved N-band emission region is determined by the hot inner rim of the disk. Continued comparisons between post-AGB and protoplanetary disks will help to understand grain growth and disk evolution processes, and to constrain planet formation theories. These second-generation disks are an important missing ingredient in binary evolution theory of intermediate-mass stars. Based on observations made with ESO Telescopes at the La Silla Paranal Observatory under programmes ID 073.A-9002, 073.A-9014, 073.D-0610, 075.D-0605, 077.D-0071, 078.D-0113, 079.D-0013, 080.D-0059, 081.D-0089, 082.D-0066, 083.D-0011, 083.D-0013, 084.D-0009, 093.D-0914, and 094.D-0778. Some observations were obtained in the framework of the Belgian Guaranteed Time allocation on VISA.

Next Generation Instrumentation for the Very Large Telescope Interferometer

NASA Astrophysics Data System (ADS)

Quirrenbach, A.

The scientific capabilities of the VLT Interferometer can be substantially enhanced through new focal-plane instruments. Many interferometric techniques - astrometry, phase-referenced imaging, nulling, and differential phase measurements - require control of the phase to <~ 1 rad; this capability will be provided at the VLTI by the PRIMA facility. Phase-coherent operation of the VLTI will also make it possible to perform interferometry with spectral resolution up to R ~ 100,000 by building fiber links to the high-resolution spectrographs UVES and CRIRES. These developments will open new approaches to fundamental problems in fields as diverse as extrasolar planets, stellar atmospheres, circumstellar matter, and active galactic nuclei.

Analyze and predict VLTI observations: the Role of 2D/3D dust continuum radiative transfer codes

NASA Astrophysics Data System (ADS)

Pascucci, I.; Henning, Th; Steinacker, J.; Wolf, S.

2003-10-01

Radiative Transfer (RT) codes with image capability are a fundamental tool for preparing interferometric observations and for interpreting visibility data. In view of the upcoming VLTI facilities, we present the first comparison of images/visibilities coming from two 3D codes that use completely different techniques to solve the problem of self-consistent continuum RT. In addition, we focus on the astrophysical case of a disk distorted by tidal interaction with by-passing stars or internal planets and investigate for which parameters the distortion can be best detected in the mid-infrared using the mid-infrared interferometric device MIDI.

2D/3D Dust Continuum Radiative Transfer Codes to Analyze and Predict VLTI Observations

NASA Astrophysics Data System (ADS)

Pascucci, I.; Henning, Th.; Steinacker, J.; Wolf, S.

Radiative Transfer (RT) codes with image capability are a fundamental tool for preparing interferometric observations and for interpreting visibility data. In view of the upcoming VLTI facilities, we present the first comparison of images/visibilities coming from two 3D codes that use completely different techniques to solve the problem of self-consistent continuum RT. In addition, we focus on the astrophysical case of a disk distorted by tidal interaction with by-passing stars or internal planets and investigate for which parameters the distortion can be best detected in the mid-infrared using the mid-infrared interferometric device MIDI.

VLT/PIONIER Imaging of Red Supergiant Stars

NASA Astrophysics Data System (ADS)

Montargès, Miguel

2018-04-01

PIONIER (Precision Integrated-Optics Near-infrared Imaging ExpeRiment) was the first 4-telescope instrument installed at the Very Large Telescope Interferometer (VLTI) in 2010. Benefiting from the multiple interferometric configurations available at the Cerro Paranal observatory, it can efficiently image stellar surfaces. With their large linear sizes, nearby red supergiant stars are among the most interesting targets for such instrument. Near infrared interferometry allows to study their surface in order to get a better understanding of their mass loss, mostly by constraining the characteristics of their photospheric features. I will review recent results obtain with VLTI/PIONIER on red supergiant stars, and emphasize the different techniques used to analyze these observations.

VLTI/GRAVITY observations of the young star βPictoris

NASA Astrophysics Data System (ADS)

Defrère, D.

2017-12-01

The nearby young star β Pictoris is surrounded by the archetypal debris disc, which provides a unique window on the formation and early evolution of terrestrial planets. While the outer disc has been extensively studied since its discovery in 1984, very little is currently known about the inner planetary system (<4AU). Recently, accurate squared visibilities obtained with VLTI/PIONIER revealed the presence of resolved circumstellar emission with an integrated brightness amounting to approximately 1.4% of the stellar brightness in H band. However, it is not clear whether this excess emission originates from thermal emission, reflected light from hot dust grains located in the innermost regions of the planetary system, or is simply due to forward scattering by dust grains located further away (but still within the PIONIER field-of-view, i.e., close to the line of sight). In this paper, we present medium-resolution K-band observations of βPic obtained with VLTI/GRAVITY during science verification. The goals of these observations are to better constrain the temperature of the grains (and hence their location and chemical composition) and to showcase the high-precision capabilities of GRAVITY at detecting faint, close-in circumstellar emission.

High angular resolution N-band observation of the silicate carbon star IRAS08002-3803 with the VLTI/MIDI instrument . Dusty environment spatially resolved

NASA Astrophysics Data System (ADS)

Ohnaka, K.; Driebe, T.; Hofmann, K.-H.; Leinert, Ch.; Morel, S.; Paresce, F.; Preibisch, Th.; Richichi, A.; Schertl, D.; Schöller, M.; Waters, L. B. F. M.; Weigelt, G.; Wittkowski, M.

2006-01-01

We present the results of N-band spectro-interferometric observations of the silicate carbon star IRAS08002-3803 with the MID-infrared Interferometric instrument (MIDI) at the Very Large Telescope Interferometer (VLTI) of the European Southern Observatory (ESO). The observations were carried out using two unit telescopes (UT2 and UT3) with projected baseline lengths ranging from 39 to 47 m. Our observations of IRAS08002-3803 have spatially resolved the dusty environment of a silicate carbon star for the first time and revealed an unexpected wavelength dependence of the angular size in the N band: the uniform-disk diameter is found to be constant and 36 mas (72 Rstar) between 8 and 10 μm, while it steeply increases longward of 10 μm to reach 53 mas (106 Rstar) at 13 μm. Model calculations with our Monte Carlo radiative transfer code show that neither spherical shell models nor axisymmetric disk models consisting of silicate grains alone can simultaneously explain the observed wavelength dependence of the visibility and the spectral energy distribution (SED). We propose that the circumstellar environment of IRAS08002-3803 may consist of two grain species coexisting in the disk: silicate and a second grain species, for which we consider amorphous carbon, large silicate grains, and metallic iron grains. Comparison of the observed visibilities and SED with our models shows that such disk models can fairly - though not entirely satisfactorily - reproduce the observed SED and N-band visibilities. Our MIDI observations and the radiative transfer calculations lend support to the picture where oxygen-rich material around IRAS08002-3803 is stored in a circumbinary disk surrounding the carbon-rich primary star and its putative low-luminosity companion.

The environment of the fast rotating star Achernar. II. Thermal infrared interferometry with VLTI/MIDI

NASA Astrophysics Data System (ADS)

Kervella, P.; Domiciano de Souza, A.; Kanaan, S.; Meilland, A.; Spang, A.; Stee, Ph.

2009-01-01

Context: As is the case of several other Be stars, Achernar is surrounded by an envelope, recently detected by near-IR interferometry. Aims: We search for the signature of circumstellar emission at distances of a few stellar radii from Achernar, in the thermal IR domain. Methods: We obtained interferometric observations on three VLTI baselines in the N band (8-13 μm), using the MIDI instrument. Results: From the measured visibilities, we derive the angular extension and flux contribution of the N band circumstellar emission in the polar direction of Achernar. The interferometrically resolved polar envelope contributes 13.4 ± 2.5% of the photospheric flux in the N band, with a full width at half maximum of 9.9 ± 2.3 mas (≈6 R_star). This flux contribution is in good agreement with the photometric IR excess of 10-20% measured by fitting the spectral energy distribution. Due to our limited azimuth coverage, we can only establish an upper limit of 5-10% for the equatorial envelope. We compare the observed properties of the envelope with an existing model of this star computed with the SIMECA code. Conclusions: The observed extended emission in the thermal IR along the polar direction of Achernar is well reproduced by the existing SIMECA model. Already detected at 2.2 μm, this polar envelope is most probably an observational signature of the fast wind ejected by the hot polar caps of the star. Based on observations made with ESO Telescopes at Paranal Observatory under programs 078.D-0295(C), (D) and (E). Table 2 is only available in electronic form at http://www.aanda.org

Future Looks Bright for Interferometry

NASA Astrophysics Data System (ADS)

2008-09-01

First Light for the PRIMA instrument The PRIMA instrument [1] of the ESO Very Large Telescope Interferometer (VLTI) recently saw "first light" at its new home atop Cerro Paranal in Chile. When fully operational, PRIMA will boost the capabilities of the VLTI to see sources much fainter than any previous interferometers, and enable astrometric precision unmatched by any other existing astronomical facility. PRIMA will be a unique tool for the detection of exoplanets. First Light of the PRIMA Instrument ESO PR Photo 29a/08 Preparing for PRIMA "PRIMA is specifically designed to see if one star 'wobbles' to and fro because it is has unseen planetary companions", says instrument scientist Gerard van Belle. "This allows us to not only detect exoplanets, but to measure their mass." PRIMA's expected astrometric precision of tens of micro-arcseconds is unmatched by any other existing astronomical facility, whether on the ground or in orbit [2]. In addition to taking astrometric measurements PRIMA will be the key to the imaging of faint sources with the VLTI using the science instruments AMBER and MIDI. Interferometry combines the light received by two or more telescopes, concentrating on tiny differences between the signals to measure angles with exquisite precision. Using this technique PRIMA can pick out details as sharply as a single telescope with a diameter equivalent to the largest distance between the telescopes. For the VLTI, the distance between the two telescope elements is about 200 metres. The PRIMA instrument is unique amongst the VLTI instruments, in that it is effectively two interferometers in one. PRIMA will take data from two sources on the sky simultaneously: the brighter source can be used for tracking, allowing the interferometer to "stare" at the fainter source for longer than is now possible with conventional interferometers. Although there have been earlier pathfinder experiments to test this technique, PRIMA represents the first facility-class instrument of its kind that is open to all astronomers. PRIMA parts arrived at the summit at Paranal at the end of July and were integrated and tested during the following month. On 2 September 2008, as a first milestone, starlight from two VLTI 1.8-m Auxiliary Telescopes was fed into the PRIMA system, and interference fringes were detected on PRIMA's Fringe Sensor Unit. Three days later the system was routinely using active tracking on the fringes, compensating for atmospheric turbulence. First light - or, in the case of interferometric instruments, first fringes - actually occurred ahead of the ambitious schedule set out by lead engineer Francoise Delplancke: "There were many activities that all had to be successful simultaneously for this to happen, but the assembly, integration, and verification went smoothly - I was pleased by how easy and reliable the fringe tracking was, for our first try." All PRIMA sub-systems [3] have been installed successfully for use with two Auxiliary Telescopes and will now be submitted to intensive commissioning tests before being offered to the community of users for routine observations [4].

MONA, LISA and VINCI Soon Ready to Travel to Paranal

NASA Astrophysics Data System (ADS)

2000-11-01

First Instruments for the VLT Interferometer Summary A few months from now, light from celestial objects will be directed for the first time towards ESO's Very Large Telescope Interferometer (VLTI) at the Paranal Observatory (Chile). During this "First Light" event and the subsequent test phase, the light will be recorded with a special test instrument, VINCI (VLT INterferometer Commissioning Instrument). The main components of this high-tech instrument are aptly named MONA (a system that combines the light beams from several telescopes by means of optical fibers) and LISA (the infrared camera). VINCI was designed and constructed within a fruitful collaboration between ESO and several research institutes and industrial companies in France and Germany . It is now being assembled at the ESO Headquarters in Garching (Germany) and will soon be ready for installation at the telescope on Paranal. With the VLTI and VINCI, Europe's astronomers are now entering the first, crucial phase of an exciting scientific and technology venture that will ultimately put the world's most powerful optical/IR interferometric facility in their hands . PR Photo 31/00 : VINCI during tests at the ESO Headquarters in Garching. The VLT Interferometer (VLTI) ESO Press Photo 31/00 ESO Press Photo 31/00 [Preview; JPEG: 400 x 301; 43k] [Normal; JPEG: 800 x 602;208xk] [Full-Res; JPEG: 1923 x 1448; 2.2Mb] PR Photo 31/00 shows the various components of the complex VINCI instrument for the VLT Interferometer , during the current tests at the Optical Laboratory at the ESO Headquarters in Garching (Germany). It will later be installed in "clean-room" conditions within the Interferometric Laboratory at the Paranal Observatory. This electronic photo was obtained for documentary purposes. VINCI (VLT INterferometer Commissioning Instrument) is the "First Light" instrument for the Very Large Telescope Interferometer (VLTI) at the Paranal Observatory (Chile). Early in 2001, it will be used for the first tests of this very complex system. Subsequently, it will serve to tune this key research facility to the highest possible performance. The VLTI is based on the combination of light (beams) from the telescopes at Paranal. Of these, the four 8.2-m Unit Telescopes are already in operation - they will soon be joined by three 1.8-m telescopes that can be relocated on rails, cf. PR Photo 43b/99. By means of a system of mirrors, the light from two or more of these telescopes will be guided to the central Interferometric Laboratory , at the center of the observing platform on Paranal. Information about the heart of this complex system, the Delay Lines that are located in the underground Interferometric Tunnel, is available with the recent ESO PR Photos 26a-e/00. The VLTI will later receive other front-line instruments, e.g. AMBER , MIDI and PRIMA. When fully ready some years from now, the VLTI will produce extremely sharp images. This will have a major impact on different types of exciting astronomical observations, e.g.: * the direct discovery and imaging of extra-solar planets comparable to Jupiter, * the discovery and imaging of low-mass stars such as brown dwarfs, * observations of star-forming regions and to better understand the physical processes that give birth to stars, * spectral analysis of the atmospheres of nearby stars, and * imaging the objects of the very core of our Galaxy and the detection of black holes in active nuclei of galaxies. The VINCI test instrument The new instrument, VINCI , will soon be delivered to Paranal by the Département de Recherche Spatiale (Department for Space Research), a joint unit of the Centre Nationale de la Recherche Scientifique (French National Centre for Scientific Research) and the Paris Observatory. VINCI is a functional copy of the FLUOR instrument - now at the IOTA (Infrared Optical Telescope Array) interferometer - that has been upgraded and adapted to the needs of the VLTI. FLUOR was developed by the Département de Recherche Spatiale (DESPA) of the Paris Observatory. It was used in 1991 at the Kitt Peak National Observatory (Arizona, USA), for the first (coherent) combination of the light beams from two independent telescopes by means of optical fibers of fluoride glass. It has since been in operation for five years as a focal instrument at the IOTA Interferometer (Mount Hopkins, Arizona, USA) within a collaboration with the Harvard Smithsonian Center for Astrophysics), producing a rich harvest of scientific data. The VINCI partners The VINCI instrument is constructed in a collaboration between ESO (that also finances it) and the following laboratories and institutes: * DESPA (Paris Observatory) provides the expertise, the general concept, the development and integration of the optomechanics (with the exception of the camera) and the electronics, * Observatoire Midi-Pyrénées that produces the control software * The LISA infrared camera is developed by the Max-Planck-Institut für Extraterrestrische Physik (Garching, Germany), and * ESO provides the IR camera electronics and the overall observational software and is also responsible for the final integration. DESPA delivered VINCI to ESO in Garching on September 27, 2000, and is now assembling the instrument in the ESO optical workshop. It will stay here during three months, until it has been fully integrated and thoroughly tested. It will then be shipped to Paranal at the beginning of next year. After set-up and further tests, the first observations on the sky are expected in late March 2001. Fluoride fibers guide the light The heart of VINCI - named MONA - is a fiber optics beam combine unit. It is the outcome of a fertile, 10-year research partnership between Science (DESPA) and Industry ("Le Verre Fluoré" [2]). Optical fibers will be used to combine the light from two telescopes inside VINCI . Since the instrument will be working in the near-infrared region of the spectrum (wavelength 2-2.5 µm), it is necessary to use optical fibers made of a special type of glass that is transparent at these wavelengths. By far the best best material for this is fluoride glass . It was invented by one of the co-founders of the company "Le Verre Fluoré", the only manufacturer of this kind of highly specialized material in the world. Optical fibers of fluoride glass from this company are therefore used in VINCI . They are of a special type ("monomode") with a very narrow core measuring only 6.5 µm (0.065 mm) across. Light that is collected by one of the telescopes in the VLTI array (e.g., by the 50 m 2 mirror of a VLT Unit Telescope) is guided through the VLTI system of optics and finally enters this core. The fibers guide the light and at the same time "clean" the light beam by eliminating the errors introduced by the atmospheric turbulence, hereby improving the accuracy of the measurements by a factor of 10. DESPA has shown that this is indeed possible by means of real astronomical observations with the FLUOR experiment. Following this positive demonstration, it has been decided to equip the instrumentation of all interferometers currently under construction with fibers or equivalent systems.

New insights on the AU-scale circumstellar structure of FU Orionis

NASA Astrophysics Data System (ADS)

Malbet, F.; Lachaume, R.; Berger, J.-P.; Colavita, M. M.; di Folco, E.; Eisner, J. A.; Lane, B. F.; Millan-Gabet, R.; Ségransan, D.; Traub, W. A.

2005-07-01

We report new near-infrared, long-baseline interferometric observations at the AU scale of the pre-main-sequence star FU Orionis with the PTI, IOTA and VLTI interferometers. This young stellar object has been observed on 42 nights over a period of 6 years from 1998 to 2003. We have obtained 287 independent measurements of the fringe visibility with 6 different baselines ranging from 20 to 110 m in length, in the H and K bands. Our data resolves FU Ori at the AU scale, and provides new constraints at shorter baselines and shorter wavelengths. Our extensive (u,v)-plane coverage, coupled with the published spectral energy distribution data, allows us to test the accretion disk scenario. We find that the most probable explanation for these observations is that FU Ori hosts an active accretion disk whose temperature law is consistent with standard models and with an accretion rate of dot M= (6.3 ± 0.6) × 10-5 (Mstar/M⊙)-1 M⊙ yr-1. We are able to constrain the geometry of the disk, including an inclination of 55-7+5 deg and a position angle of 47-11 0+7 deg. In addition, a 10 percent peak-to-peak oscillation is detected in the data (at the two-sigma level) from the longest baselines, which we interpret as a possible disk hot-spot or companion. The still somewhat limited (u, v) sampling and substantial measurement uncertainty prevent us from constraining the location of the spot with confidence, since many solutions yield a statistically acceptable fit. However, the oscillation in our best data set is best explained with an unresolved spot located at a projected distance of 10 ± 1 AU at the 130 ± 1 deg position angle and with a magnitude difference of Δ K ≈ 3.9 ± 0.2 and Δ H ≈ 3.6 ± 0.2 mag moving away from the center at a rate of 1.2 ± 0.6 AU yr-1. Although this bright spot on the surface of the disk could be tracing some thermal instabilities in the disk, we propose to interpret this spot as the signature of a companion of the central FU Ori system on an extremely eccentric orbit. We speculate that the close encounter of this putative companion and the central star could be the explanation of the initial photometric rise of the luminosity of this object.

Flattest Star Ever Seen

NASA Astrophysics Data System (ADS)

2003-06-01

VLT Interferometer Measurements of Achernar Challenge Stellar Theory Summary To a first approximation, planets and stars are round. Think of the Earth we live on. Think of the Sun, the nearest star, and how it looks in the sky. But if you think more about it, you realize that this is not completely true. Due to its daily rotation, the solid Earth is slightly flattened ("oblate") - its equatorial radius is some 21 km (0.3%) larger than the polar one. Stars are enormous gaseous spheres and some of them are known to rotate quite fast, much faster than the Earth. This would obviously cause such stars to become flattened. But how flat? Recent observations with the VLT Interferometer (VLTI) at the ESO Paranal Observatory have allowed a group of astronomers [1] to obtain by far the most detailed view of the general shape of a fast-spinning hot star, Achernar (Alpha Eridani) , the brightest in the southern constellation Eridanus (The River). They find that Achernar is much flatter than expected - its equatorial radius is more than 50% larger than the polar one! In other words, this star is shaped very much like the well-known spinning-top toy, so popular among young children. The high degree of flattening measured for Achernar - a first in observational astrophysics - now poses an unprecedented challenge for theoretical astrophysics . The effect cannot be reproduced by common models of stellar interiors unless certain phenomena are incorporated, e.g. meridional circulation on the surface ("north-south streams") and non-uniform rotation at different depths inside the star. As this example shows, interferometric techniques will ultimately provide very detailed information about the shapes, surface conditions and interior structure of stars . PR Photo 15a/03 : The VLT Interferometer configuration for the Achernar measurements PR Photo 15b/03 : Achernar's "profile" , as measured by the VLTI. PR Photo 15c/03 : Models of Achernar's spatial shape. VLTI observations of Achernar ESO PR Photo 15a/03 ESO PR Photo 15a/03 [Preview - JPEG: 400 x 502 pix - 40k [Normal - JPEG: 800 x 1004 pix - 216k] Caption :PR Photo 15a/03 shows the configuration of the VLT Interferometer (VLTI) for the measurements of Achernar , described in this press release. The moveable, 40-cm test telescopes were positioned at specific "stations" (E0 + G1; B3 + M0; with baselines of 66 m and 140 m, respectively), allowing contiguous measurements in two nearly perpendicular directions. The two light beams were then sent via the path-compensating VLTI Delay Lines to the VINCI test instrument where they combined to form interferometric fringes. The positions of the four 8.2-m VLT Unit Telescopes are indicated by numbered circles. Test observations with the VLT Interferometer (VLTI) at the Paranal Observatory proceed well [2], and the astronomers have now begun to exploit many of these first measurements for scientific purposes. One spectacular result, just announced, is based on a series of observations of the bright, southern star Achernar (Alpha Eridani; the name is derived from "Al Ahir al Nahr" = "The End of the River"), carried out between September 11 and November 12, 2002. The two 40-cm siderostat test telescopes that served to obtain "First Light" with the VLT Interferometer in March 2001 were also used for these observations. They were placed at selected positions on the VLT Observing Platform at the top of Paranal to provide a "cross-shaped" configuration with two "baselines" of 66 m and 140 m, respectively, at 90° angle, cf. PR Photo 15a/03 . At regular time intervals, the two small telescopes were pointed towards Achernar and the two light beams were directed to a common focus in the VINCI test instrument in the centrally located VLT Interferometric Laboratory. Due to the Earth's rotation during the observations, it was possible to measure the angular size of the star (as seen in the sky) in different directions. Achernar's profile ESO PR Photo 15b/03 ESO PR Photo 15b/03 [Preview - JPEG: 400 x 464 pix - 35k [Normal - JPEG: 800 x 927 pix - 176k] Caption: PR Photo 15b/03 shows the profile of the rapidly rotating star Achernar , as deduced from observations with the VLT Interferometer (VLTI) [3]. The size is indicated in units of 0.001 arcsec (milli-arcsec). Individual angular diameter measurements are indicated by pairs of small points with associated error bars on opposite sides of the center. The fully drawn curve represents the best fitting ellipse. The ratio of the axes is 1.56 ± 0.05. The major axis of this ellipse is a measure of the "real" size of the star. Because of the projection effect, the minor axis shows the largest possible extension in the perpendicular direction. The axes ratio is therefore a minimal value; the star may be even more flattened than suggested by this ellipse. A first attempt to measure the geometrical deformation of a rapidly rotating star was carried out in 1974 with the Narrabri Intensity Interferometer (Australia) on the bright star Altair by British astronomer Hanbury Brown . However, because of technical limitations, those observations were unable to decide between different models for this star. More recently, Gerard T. Van Belle and collaborators observed Altair with the Palomar Testbed Interferometer (PTI) , measuring its apparent axial ratio as 1.140 ± 0.029 and placing some constraints upon the relationship between rotation velocity and stellar inclination. Achernar is a star of the hot B-type, with a mass of 6 times that of the Sun. The surface temperature is about 20,000 °C and it is located at a distance of 145 light-years. The apparent profile of Achernar ( PR Photo 15b/03 ), based on about 20,000 VLTI interferograms (in the K-band at wavelength 2.2 µm) with a total integration time of over 20 hours, indicates a surprisingly high axial ratio of 1.56 ± 0.05 [3]. This is obviously a result of Achernar's rapid rotation. Theoretical implications of the VLTI observations ESO PR Photo 15c/03 ESO PR Photo 15c/03 [Preview - JPEG: 816 x 400 pix - 67k [Normal - JPEG: 1792 x 800 pix - 224k] Caption:PR Photo 15c/03 provides a model view of Achernar , based on the profile measured with the VLTI, cf. PR Photo 15b/03 . Two different models are shown: in "A", the polar axis is inclined 50° to the line-of-sight; in "B", this angle is 90° The angular size of Achernar's elliptical profile as indicated in PR Photo 15b/03 is 0.00253 ± 0.00006 arcsec (major axis) and 0.00162 ± 0.00001 arcsec (minor axis) [4], respectively. At the indicated distance, the corresponding stellar radii are equal to 12.0 ± 0.4 and 7.7 ± 0.2 solar radii, or 8.4 and 5.4 million km, respectively. The first value is a measure of the star's equatorial radius. The second is an upper value for the polar radius - depending on the inclination of the star's polar axis to the line-of-sight, it may well be even smaller. The indicated ratio between the equatorial and polar radii of Achernar constitutes an unprecedented challenge for theoretical astrophysics, in particular concerning mass loss from the surface enhanced by the rapid rotation (the centrifugal effect) and also the distribution of internal angular momentum (the rotation velocity at different depths). The astronomers conclude that Achernar must either rotate faster (and hence, closer to the "critical" (break-up) velocity of about 300 km/sec) than what the spectral observations show (about 225 km/sec from the widening of the spectral lines) or it must violate the rigid-body rotation. The observed flattening cannot be reproduced by the "Roche-model" that implies solid-body rotation and mass concentration at the center of the star. The failure of that model is even more evident if the so-called "gravity darkening" effect is taken into account - this is a non-uniform temperature distribution on the surface which is certainly present on Achernar under such a strong geometrical deformation. Outlook This new measurement provides a fine example of what is possible with the VLT Interferometer already at this stage of implementation. It bodes well for the future research projects at this facility. With the interferometric technique, new research fields are now opening which will ultimately provide much more detailed information about the shapes, surface conditions and interior structure of stars. And in a not too distant future, it will become possible to produce interferometric images of the disks of Achernar and other stars. More information The research described in this press release is presented in a Letter to the Editor, soon to appear in the European research journal Astronomy & Astrophysics ("The spinning-top Be star Achernar from VLTI-VINCI" by Armando Domiciano de Souza et al.).

VLTI + MIDI Study of the High Mass Protostellar Candidate NGC 3603 IRS 9A

NASA Astrophysics Data System (ADS)

Nürnberger, D. E. A.; Vehoff, S.; Hummel, C. A.; Duschl, W. J.

2010-02-01

The formation and early evolution of high mass stars is among the hottest topics in astrophysics. Interferometric studies of these young stars and their circumstellar environments (envelopes, disks and jets) at near and mid infrared wavelengths are still rare and in terms of data analysis/interpretation very challenging. We here report on observations of the high mass protostellar candidate NGC 3603 IRS 9A which we undertook with VLTI + MIDI in 2005, complemented by near and mid infrared imaging and spectroscopic data. We discuss our results obtained from dedicated modeling efforts, employing both DUSTY and MC3D radiative transfer codes for a selected number of source geometries and surface brightness distributions.

Observation planning tools for the ESO VLT interferometer

NASA Astrophysics Data System (ADS)

McKay, Derek J.; Ballester, Pascal; Vinther, Jakob

2004-09-01

Now that the Very Large Telescope Interferometer (VLTI) is producing regular scientific observations, the field of optical interferometry has moved from being a specialist niche area into mainstream astronomy. Making such instruments available to the general community involves difficult challenges in modelling, presentation and automation. The planning of each interferometric observation requires calibrator source selection, visibility prediction, signal-to-noise estimation and exposure time calculation. These planning tools require detailed physical models simulating the complete telescope system - including the observed source, atmosphere, array configuration, optics, detector and data processing. Only then can these software utilities provide accurate predictions about instrument performance, robust noise estimation and reliable metrics indicating the anticipated success of an observation. The information must be presented in a clear, intelligible manner, sufficiently abstract to hide the details of telescope technicalities, but still giving the user a degree of control over the system. The Data Flow System group has addressed the needs of the VLTI and, in doing so, has gained some new insights into the planning of observations, and the modelling and simulation of interferometer performance. This paper reports these new techniques, as well as the successes of the Data Flow System group in this area and a summary of what is now offered as standard to VLTI observers.

Fast ray-tracing algorithm for circumstellar structures (FRACS). II. Disc parameters of the B[e] supergiant CPD-57°,2874 from VLTI/MIDI data

NASA Astrophysics Data System (ADS)

Domiciano de Souza, A.; Bendjoya, P.; Niccolini, G.; Chesneau, O.; Borges Fernandes, M.; Carciofi, A. C.; Spang, A.; Stee, P.; Driebe, T.

2011-01-01

Context. B[e] supergiants are luminous, massive post-main sequence stars exhibiting non-spherical winds, forbidden lines, and hot dust in a disc-like structure. The physical properties of their rich and complex circumstellar environment (CSE) are not well understood, partly because these CSE cannot be easily resolved at the large distances found for B[e] supergiants (typically ⪆1 kpc). Aims: From mid-IR spectro-interferometric observations obtained with VLTI/MIDI we seek to resolve and study the CSE of the Galactic B[e] supergiant CPD-57° 2874. Methods: For a physical interpretation of the observables (visibilities and spectrum) we use our ray-tracing radiative transfer code (FRACS), which is optimised for thermal spectro-interferometric observations. Results: Thanks to the short computing time required by FRACS (<10 s per monochromatic model), best-fit parameters and uncertainties for several physical quantities of CPD-57° 2874 were obtained, such as inner dust radius, relative flux contribution of the central source and of the dusty CSE, dust temperature profile, and disc inclination. Conclusions: The analysis of VLTI/MIDI data with FRACS allowed one of the first direct determinations of physical parameters of the dusty CSE of a B[e] supergiant based on interferometric data and using a full model-fitting approach. In a larger context, the study of B[e] supergiants is important for a deeper understanding of the complex structure and evolution of hot, massive stars. Based on VLTI/MIDI observations collected at the European Southern Observatory (ESO), Paranal, Chile under ESO Programmes 074.D-0101 and 078.D-0213. Also based on observations at the ESO 2.2-m telescope, La Silla, Chile, under agreement with the Observatório Nacional-MCT (Brazil).Figure 5 is only available in electronic form at http://www.aanda.org

Analysis and optimization of hybrid electric vehicle thermal management systems

NASA Astrophysics Data System (ADS)

Hamut, H. S.; Dincer, I.; Naterer, G. F.

2014-02-01

In this study, the thermal management system of a hybrid electric vehicle is optimized using single and multi-objective evolutionary algorithms in order to maximize the exergy efficiency and minimize the cost and environmental impact of the system. The objective functions are defined and decision variables, along with their respective system constraints, are selected for the analysis. In the multi-objective optimization, a Pareto frontier is obtained and a single desirable optimal solution is selected based on LINMAP decision-making process. The corresponding solutions are compared against the exergetic, exergoeconomic and exergoenvironmental single objective optimization results. The results show that the exergy efficiency, total cost rate and environmental impact rate for the baseline system are determined to be 0.29, ¢28 h-1 and 77.3 mPts h-1 respectively. Moreover, based on the exergoeconomic optimization, 14% higher exergy efficiency and 5% lower cost can be achieved, compared to baseline parameters at an expense of a 14% increase in the environmental impact. Based on the exergoenvironmental optimization, a 13% higher exergy efficiency and 5% lower environmental impact can be achieved at the expense of a 27% increase in the total cost.

Spatially resolved mid-infrared observations of the triple system T Tauri

NASA Astrophysics Data System (ADS)

Ratzka, Th.; Schegerer, A. A.; Leinert, Ch.; Ábrahám, P.; Henning, Th.; Herbst, T. M.; Köhler, R.; Wolf, S.; Zinnecker, H.

2009-08-01

Aims: The aim of this study is to enhance our knowledge of the characteristics and distribution of the circumstellar dust associated with the individual components of the young hierarchical triple system T Tau. Methods: To reach this goal, observations in the N-band (8-13 μm) with the two-telescope interferometric instrument MIDI at the VLTI were performed. For the northern component of the T Tau system, projected baseline lengths of 43 m, 62 m, and 85 m were used. For the southern binary projected baseline lengths of equivalent resolution could be utilised. Our study is based on both the interferometric and the spectrophotometric measurements and is supplemented by new visual and infrared photometry. Also, the phases were investigated to determine the dominating mid-infrared source in the close southern binary. The data were fit with the help of a sophisticated physical disc model. This model utilises the radiative transfer code MC3D that is based on the Monte-Carlo method. Results: Extended mid-infrared emission is found around all three components of the system. Simultaneous fits to the photometric and interferometric data confirm the picture of an almost face-on circumstellar disc around T Tau N. Towards this star, the silicate band is seen in emission. This emission feature is used to model the dust content of the circumstellar disc. Clear signs of dust processing are found. Towards T Tau S, the silicate band is seen in absorption. This absorption is strongly pronounced towards the infrared companion T Tau Sa as can be seen from the first individual N-band spectra for the two southern components. Our fits support the previous suggestion that an almost edge-on disc is present around T Tau Sa. This disc is thus misaligned with respect to the circumstellar disc around T Tau N. The interferometric data indicate that the disc around T Tau Sa is oriented in the north-south direction, which favours this source as launching site for the east-western jet. We further determine from the interferometric data the relative positions of the components of the southern binary in the N-band. We find good agreement with recent position measurements in the near-infrared. Based on observations with the Very Large Telescope Interferometer (VLTI, proposal 074. C-0209(A) and 077.C-0176(C)).

VLBI-resolution radio-map algorithms: Performance analysis of different levels of data-sharing on multi-socket, multi-core architectures

NASA Astrophysics Data System (ADS)

Tabik, S.; Romero, L. F.; Mimica, P.; Plata, O.; Zapata, E. L.

2012-09-01

A broad area in astronomy focuses on simulating extragalactic objects based on Very Long Baseline Interferometry (VLBI) radio-maps. Several algorithms in this scope simulate what would be the observed radio-maps if emitted from a predefined extragalactic object. This work analyzes the performance and scaling of this kind of algorithms on multi-socket, multi-core architectures. In particular, we evaluate a sharing approach, a privatizing approach and a hybrid approach on systems with complex memory hierarchy that includes shared Last Level Cache (LLC). In addition, we investigate which manual processes can be systematized and then automated in future works. The experiments show that the data-privatizing model scales efficiently on medium scale multi-socket, multi-core systems (up to 48 cores) while regardless of algorithmic and scheduling optimizations, the sharing approach is unable to reach acceptable scalability on more than one socket. However, the hybrid model with a specific level of data-sharing provides the best scalability over all used multi-socket, multi-core systems.

An edge-on translucent dust disk around the nearest AGB star, L2 Puppis. VLT/NACO spectro-imaging from 1.04 to 4.05 μm and VLTI interferometry

NASA Astrophysics Data System (ADS)

Kervella, P.; Montargès, M.; Ridgway, S. T.; Perrin, G.; Chesneau, O.; Lacour, S.; Chiavassa, A.; Haubois, X.; Gallenne, A.

2014-04-01

As the nearest known AGB star (d = 64 pc) and one of the brightest (mK ≈ -2), L2 Pup is a particularly interesting benchmark object to monitor the final stages of stellar evolution. We report new serendipitous imaging observations of this star with the VLT/NACO adaptive optics system in twelve narrow-band filters covering the 1.0-4.0 μm wavelength range. These diffraction-limited images reveal an extended circumstellar dust lane in front of the star that exhibits a high opacity in the J band and becomes translucent in the H and K bands. In the L band, extended thermal emission from the dust is detected. We reproduced these observations using Monte Carlo radiative transfer modeling of a dust disk with the RADMC-3D code. We also present new interferometric observations with the VLTI/VINCI and MIDI instruments. We measured in the K band an upper limit to the limb-darkened angular diameter of θLD = 17.9 ± 1.6 mas, converting to a maximum linear radius of R = 123 ± 14 R⊙. Considering the geometry of the extended K band emission in the NACO images, this upper limit is probably close to the actual angular diameter of the star. The position of L2 Pup in the Hertzsprung-Russell diagram indicates that this star has a mass of about 2 M⊙ and is probably experiencing an early stage of the asymptotic giant branch. We did not detect any stellar companion of L2 Pup in our adaptive optics and interferometric observations, and we attribute its apparent astrometric wobble in the Hipparcos data to variable lighting effects on its circumstellar material. However, we do not exclude the presence of a binary companion, because the large loop structure extending to more than 10 AU to the northeast of the disk in our L-band images may be the result of interaction between the stellar wind of L2 Pup and a hidden secondary object. The geometric configuration that we propose, with a large dust disk seen almost edge-on, appears particularly favorable to test and develop our understanding of the formation of bipolar nebulae. Based on observations made with ESO telescopes at Paranal Observatory, under ESO programs 090.D-0144(A), 074.D-0198(C) and an unreferenced VLTI/VINCI program.FITS files are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/564/A88

Integrated optics prototype beam combiner for long baseline interferometry in the L and M bands

NASA Astrophysics Data System (ADS)

Tepper, J.; Labadie, L.; Diener, R.; Minardi, S.; Pott, J.-U.; Thomson, R.; Nolte, S.

2017-06-01

Context. Optical long baseline interferometry is a unique way to study astronomical objects at milli-arcsecond resolutions not attainable with current single-dish telescopes. Yet, the significance of its scientfic return strongly depends on a dense coverage of the uv-plane and a highly stable transfer function of the interferometric instrument. In the last few years, integrated optics (IO) beam combiners have facilitated the emergence of 4-telescope interferometers such as PIONIER or GRAVITY, boosting the imaging capabilities of the VLTI. However, the spectral range beyond 2.2 μm is not ideally covered by the conventional silica based IO. Here, we consider new laser-written IO prototypes made of gallium lanthanum sulfide (GLS) glass, a material that permits access to the mid-infrared spectral regime. Aims: Our goal is to conduct a full characterization of our mid-IR IO two-telescope coupler in order to measure the performance levels directly relevant for long-baseline interferometry. We focus in particular on the exploitation of the L and M astronomical bands. Methods: We use a dedicated Michelson-interferometer setup to perform Fourier transform spectroscopy on the coupler and measure its broadband interferometric performance. We also analyze the polarization properties of the coupler, the differential dispersion and phase degradation, as well as the modal behavior and the total throughput. Results: We measure broadband interferometric contrasts of 94.9% and 92.1% for unpolarized light in the L and M bands. Spectrally integrated splitting ratios are close to 50%, but show chromatic dependence over the considered bandwidths. Additionally, the phase variation due to the combiner is measured and does not exceed 0.04 rad and 0.07 rad across the L and M band, respectively. The total throughput of the coupler including Fresnel and injection losses from free-space is 25.4%. Furthermore, differential birefringence is low (<0.2 rad), in line with the high contrasts reported for unpolarized light. Conclusions: The laser-written IO GLS prototype combiners prove to be a reliable technological solution with promising performance for mid-infrared long-baseline interferometry. In the next steps, we will consider more advanced optical functions, as well as a fiber-fed input, and we will revise the optical design parameters in order to further enhance the total throughput and achromatic behavior.

The Sky Through Three Giant Eyes

NASA Astrophysics Data System (ADS)

2007-02-01

AMBER Instrument on VLT Delivers a Wealth of Results The ESO Very Large Telescope Interferometer, which allows astronomers to scrutinise objects with a precision equivalent to that of a 130-m telescope, is proving itself an unequalled success every day. One of the latest instruments installed, AMBER, has led to a flurry of scientific results, an anthology of which is being published this week as special features in the research journal Astronomy & Astrophysics. ESO PR Photo 06a/07 ESO PR Photo 06a/07 The AMBER Instrument "With its unique capabilities, the VLT Interferometer (VLTI) has created itself a niche in which it provide answers to many astronomical questions, from the shape of stars, to discs around stars, to the surroundings of the supermassive black holes in active galaxies," says Jorge Melnick (ESO), the VLT Project Scientist. The VLTI has led to 55 scientific papers already and is in fact producing more than half of the interferometric results worldwide. "With the capability of AMBER to combine up to three of the 8.2-m VLT Unit Telescopes, we can really achieve what nobody else can do," added Fabien Malbet, from the LAOG (France) and the AMBER Project Scientist. Eleven articles will appear this week in Astronomy & Astrophysics' special AMBER section. Three of them describe the unique instrument, while the other eight reveal completely new results about the early and late stages in the life of stars. ESO PR Photo 06b/07 ESO PR Photo 06b/07 The Inner Winds of Eta Carinae The first results presented in this issue cover various fields of stellar and circumstellar physics. Two papers deal with very young solar-like stars, offering new information about the geometry of the surrounding discs and associated outflowing winds. Other articles are devoted to the study of hot active stars of particular interest: Alpha Arae, Kappa Canis Majoris, and CPD -57o2874. They provide new, precise information about their rotating gas envelopes. An important new result concerns the enigmatic object Eta Carinae. Using AMBER with its high spatial and spectral resolution, it was possible to zoom into the very heart of this very massive star. In this innermost region, the observations are dominated by the extremely dense stellar wind that totally obscures the underlying central star. The AMBER observations show that this dense stellar wind is not spherically symmetric, but exhibits a clearly elongated structure. Overall, the AMBER observations confirm that the extremely high mass loss of Eta Carinae's massive central star is non-spherical and much stronger along the poles than in the equatorial plane. This is in agreement with theoretical models that predict such an enhanced polar mass-loss in the case of rapidly rotating stars. ESO PR Photo 06c/07 ESO PR Photo 06c/07 RS Ophiuchi in Outburst Several papers from this special feature focus on the later stages in a star's life. One looks at the binary system Gamma 2 Velorum, which contains the closest example of a star known as a Wolf-Rayet. A single AMBER observation allowed the astronomers to separate the spectra of the two components, offering new insights in the modeling of Wolf-Rayet stars, but made it also possible to measure the separation between the two stars. This led to a new determination of the distance of the system, showing that previous estimates were incorrect. The observations also revealed information on the region where the winds from the two stars collide. The famous binary system RS Ophiuchi, an example of a recurrent nova, was observed just 5 days after it was discovered to be in outburst on 12 February 2006, an event that has been expected for 21 years. AMBER was able to detect the extension of the expanding nova emission. These observations show a complex geometry and kinematics, far from the simple interpretation of a spherical fireball in extension. AMBER has detected a high velocity jet probably perpendicular to the orbital plane of the binary system, and allowed a precise and careful study of the wind and the shockwave coming from the nova. The stream of results from the VLTI and AMBER is no doubt going to increase in the coming years with the availability of new functionalities. "In addition to the 8.2-m Unit Telescopes, the VLTI can also combine the light from up to 4 movable 1.8-m Auxiliary Telescopes. AMBER fed by three of these AT's will be offered to the user community as of April this year, and from October we will also make FINITO available," said Melnick. "This 'fringe-tracking' device allows us to stabilise changes in the atmospheric conditions and thus to substantially improve the efficiency of the observations. By effectively 'freezing' the interferometric fringes, FINITO allows astronomers to significantly increase the exposure times." The Astronomy & Astrophysics special feature (volume 464 - March II 2007) on AMBER first results includes 11 articles. They are freely available on the A&A web site. More Information The AMBER consortium, led by Romain Petrov (Nice, France), includes researchers from the Laboratoire d'Astrophysique de Grenoble (France), Laboratoire d'Astrophysique Universitaire de Nice (France), Max-Planck Institut für Radioastronomie (Bonn, Germany), INAF-Osservatorio Astrofisico di Arcetri (Italy), and the Observatoire de la Côte d'Azur (Nice, France). In March 2004, the first on-line tests of AMBER (Astronomical Multiple BEam Recombiner) were completed, when astronomers combined the two beams of light from the southern star Theta Centauri from two test 40-cm aperture telescopes (ESO 07/04). It was later used to combine light from two, then three Unit Telescopes of ESO's VLT and light from the Auxiliary Telescopes. AMBER is part of the VLT Interferometer (VLTI) and completes the planned set of first-generation instruments for this facility. It continues the success story of the interferometric mode of the VLT, following the unique initial scientific results obtained by the VINCI and MIDI instruments, the installation of the four MACAO adaptive optics systems and the recent arrival of the last of the four 1.8-m Auxiliary Telescopes at Paranal. The principle of the interferometric technique is to combine the light collected by two or more telescopes. The greater the distance between the telescopes, the more details one can detect. For the VLTI, this distance can be up to 200 metres, providing observers with milli-arcsecond spatial resolution. With such a high spatial resolution, one would be able to distinguish between the headlights of a car located on the Moon. In addition, AMBER also provides astronomers with spectroscopic measurements, allowing the structure and the physics of the source to be constrained by comparing the measures at different wavelengths. AMBER combines the light beams from three telescopes - this is a world first for large telescopes such as the VLT. The ability to combine three beams, rather than just two as in a conventional interferometer, provides a substantial increase in the efficiency of observations, permitting astronomers to obtain three baselines simultaneously instead of one. The combination of these three baselines also permits the computation of the so-called closure phase, an important mathematical quantity that can be used in imaging applications. The AMBER instrument is mounted on a 4.2 x 1.5-m precision optical table, placed in the VLT Interferometric Laboratory at the top of the Paranal mountain. The total shipping weight of the instrument and its extensive associated electronics was almost 4 tons. Two of the results discussed here were already presented as ESO press releases in ESO 29/05 and 35/06.

Mid-infrared interferometry of AGNs: A statistical view into the dusty nuclear environment of the Seyfert Galaxies.

NASA Astrophysics Data System (ADS)

Lopez-Gonzaga, N.

2015-09-01

The high resolution achieved by the instrument MIDI at the VLTI allowed to obtain more detail information about the geometry and structure of the nuclear mid-infrared emission of AGNs, but due to the lack of real images, the interpretation of the results is not an easy task. To profit more from the high resolution data, we developed a statistical tool that allows interpret these data using clumpy torus models. A statistical approach is needed to overcome effects such as, the randomness in the position of the clouds and the uncertainty of the true position angle on the sky. Our results, obtained by studying the mid-infrared emission at the highest resolution currently available, suggest that the dusty environment of Type I objects is formed by a lower number of clouds than Type II objects.

Safety and efficacy of a multi-electrode renal sympathetic denervation system in resistant hypertension: the EnligHTN I trial

PubMed Central

Worthley, Stephen G.; Tsioufis, Costas P.; Worthley, Matthew I.; Sinhal, Ajay; Chew, Derek P.; Meredith, Ian T.; Malaiapan, Yuvi; Papademetriou, Vasilios

2013-01-01

Aims Catheter-based renal artery sympathetic denervation has emerged as a novel therapy for treatment of patients with drug-resistant hypertension. Initial studies were performed using a single electrode radiofrequency catheter, but recent advances in catheter design have allowed the development of multi-electrode systems that can deliver lesions with a pre-determined pattern. This study was designed to evaluate the safety and efficacy of the EnligHTN™ multi-electrode system. Methods and results We conducted the first-in-human, prospective, multi-centre, non-randomized study in 46 patients (67% male, mean age 60 years, and mean baseline office blood pressure 176/96 mmHg) with drug-resistant hypertension. The primary efficacy objective was change in office blood pressure from baseline to 6 months. Safety measures included all adverse events with a focus on the renal artery and other vascular complications and changes in renal function. Renal artery denervation, using the EnligHTN™ system significantly reduced the office blood pressure from baseline to 1, 3, and 6 months by −28/10, −27/10 and −26/10 mmHg, respectively (P < 0.0001). No acute renal artery injury or other serious vascular complications occurred. Small, non-clinically relevant, changes in average estimated glomerular filtration rate were reported from baseline (87 ± 19 mL/min/1.73 m2) to 6 months post-procedure (82 ± 20 mL/min/1.73 m2). Conclusion Renal sympathetic denervation, using the EnligHTN™ multi-electrode catheter results in a rapid and significant office blood pressure reduction that was sustained through 6 months. The EnligHTN™ system delivers a promising therapy for the treatment of drug-resistant hypertension. PMID:23782649

Safety and efficacy of a multi-electrode renal sympathetic denervation system in resistant hypertension: the EnligHTN I trial.

PubMed

Worthley, Stephen G; Tsioufis, Costas P; Worthley, Matthew I; Sinhal, Ajay; Chew, Derek P; Meredith, Ian T; Malaiapan, Yuvi; Papademetriou, Vasilios

2013-07-01

Catheter-based renal artery sympathetic denervation has emerged as a novel therapy for treatment of patients with drug-resistant hypertension. Initial studies were performed using a single electrode radiofrequency catheter, but recent advances in catheter design have allowed the development of multi-electrode systems that can deliver lesions with a pre-determined pattern. This study was designed to evaluate the safety and efficacy of the EnligHTN(™) multi-electrode system. We conducted the first-in-human, prospective, multi-centre, non-randomized study in 46 patients (67% male, mean age 60 years, and mean baseline office blood pressure 176/96 mmHg) with drug-resistant hypertension. The primary efficacy objective was change in office blood pressure from baseline to 6 months. Safety measures included all adverse events with a focus on the renal artery and other vascular complications and changes in renal function. Renal artery denervation, using the EnligHTN system significantly reduced the office blood pressure from baseline to 1, 3, and 6 months by -28/10, -27/10 and -26/10 mmHg, respectively (P < 0.0001). No acute renal artery injury or other serious vascular complications occurred. Small, non-clinically relevant, changes in average estimated glomerular filtration rate were reported from baseline (87 ± 19 mL/min/1.73 m2) to 6 months post-procedure (82 ± 20 mL/min/1.73 m2). Renal sympathetic denervation, using the EnligHTN multi-electrode catheter results in a rapid and significant office blood pressure reduction that was sustained through 6 months. The EnligHTN system delivers a promising therapy for the treatment of drug-resistant hypertension.

A search for changing look quasars in second epoch imaging

NASA Astrophysics Data System (ADS)

Findlay, Joseph; Myers, Adam; McGreer, Ian

2018-01-01

Over nearly two decades, the Sloan Digital Sky Survey has compiled a catalog of over half a million confirmed quasars. During that period approximately ten percent of these objects have been spectroscopically observed in two or more epochs over baselines of ten or more years. This led recently to the discovery of the largest change in luminosity ever before observed in a quasar. The dimming emission was a reflection of very significant changes in continuum and broad line properties, the source had effectively transitioned from a Type I quasar to a Type II AGN. Since then several more "changing look" quasars have been discovered in multi-epoch SDSS spectroscopy. Among them are objects with rising and falling luminosities, appearing and disappearing broad lines. The origin of this behavior is still very uncertain, currently favored is the scenario in which an accreting black hole is simply starved of fuel. Other plausible scenarios include flaring due to stellar tidal disruption close to the black hole or large changes in accretion flow, which can occur during transitions between radiatively efficient and inefficient accretion regimes. Monitoring of larger numbers of changing look quasars will help to elucidate these ideas.In this poster, we report on the progress of a pilot study in which we hope to learn how to select changing look quasars in multi-epoch imaging. This will allow us to take advantage of the entire SDSS quasar catalog rather than just the ten percent of objects with multi-epoch spectroscopy. Comparing archival SDSS and more recent Legacy Survey imaging over ten-year baselines we select objects whose photometry is consistent with the large changes in luminosity expected in changing look quasars. We aim to build up a catalog of both transitioned and transitioning objects for future monitoring.

Tests of stellar model atmospheres by optical interferometry. VLTI/VINCI limb-darkening measurements of the M4 giant ψ Phe

NASA Astrophysics Data System (ADS)

Wittkowski, M.; Aufdenberg, J. P.; Kervella, P.

2004-01-01

We present K-band interferometric measurements of the limb-darkened (LD) intensity profile of the M 4 giant star ψ Phoenicis obtained with the Very Large Telescope Interferometer (VLTI) and its commissioning instrument VINCI. High-precision squared visibility amplitudes in the second lobe of the visibility function were obtained employing two 8.2 m Unit Telescopes (UTs). This took place one month after light from UTs was first combined for interferometric fringes. In addition, we sampled the visibility function at small spatial frequencies using the 40 cm test siderostats. Our measurement constrains the diameter of the star as well as its center-to-limb intensity variation (CLV). We construct a spherical hydrostatic PHOENIX model atmosphere based on spectrophotometric data from the literature and compare its CLV prediction with our interferometric measurement. We compare as well CLV predictions by plane-parallel hydrostatic PHOENIX, ATLAS 9, and ATLAS 12 models. We find that the Rosseland angular diameter as predicted by comparison of the spherical PHOENIX model with spectrophotometry is in good agreement with our interferometric diameter measurement. The shape of our measured visibility function in the second lobe is consistent with all considered PHOENIX and ATLAS model predictions, and is significantly different to uniform disk (UD) and fully darkened disk (FDD) models. We derive high-precision fundamental parameters for ψ Phe, namely a Rosseland angular diameter of 8.13 ± 0.2 mas, with the Hipparcos parallax corresponding to a Rosseland linear radius R of 86 ± 3 R⊙, and an effective temperature of 3550 ± 50 K, with R corresponding to a luminosity of \\log L/L⊙=3.02 ± 0.06. Together with evolutionary models, these values are consistent with a mass of 1.3 ± 0.2 M⊙, and a surface gravity of \\log g = 0.68 ± 0.11. Based on public data released from the European Southern Observatory VLTI obtained from the ESO/ST-ECF Science Archive Facility. The VLTI was operated with the commissioning instrument VINCI and the MONA beam combiner.

Improved Topographic Mapping Through Multi-Baseline SAR Interferometry with MAP Estimation

NASA Astrophysics Data System (ADS)

Dong, Yuting; Jiang, Houjun; Zhang, Lu; Liao, Mingsheng; Shi, Xuguo

2015-05-01

There is an inherent contradiction between the sensitivity of height measurement and the accuracy of phase unwrapping for SAR interferometry (InSAR) over rough terrain. This contradiction can be resolved by multi-baseline InSAR analysis, which exploits multiple phase observations with different normal baselines to improve phase unwrapping accuracy, or even avoid phase unwrapping. In this paper we propose a maximum a posteriori (MAP) estimation method assisted by SRTM DEM data for multi-baseline InSAR topographic mapping. Based on our method, a data processing flow is established and applied in processing multi-baseline ALOS/PALSAR dataset. The accuracy of resultant DEMs is evaluated by using a standard Chinese national DEM of scale 1:10,000 as reference. The results show that multi-baseline InSAR can improve DEM accuracy compared with single-baseline case. It is noteworthy that phase unwrapping is avoided and the quality of multi-baseline InSAR DEM can meet the DTED-2 standard.

Imaging Young Stellar Objects with VLTi/PIONIER

NASA Astrophysics Data System (ADS)

Kluska, J.; Malbet, F.; Berger, J.-P.; Benisty, M.; Lazareff, B.; Le Bouquin, J.-B.; Baron, F.; Dominik, C.; Isella, A.; Juhasz, A.; Kraus, S.; Lachaume, R.; Ménard, F.; Millan-Gabet, R.; Monnier, J.; Pinte, C.; Soulez, F.; Tallon, M.; Thi, W.-F.; Thiébaut, É.; Zins, G.

2014-04-01

Optical interferometry imaging is designed to help us to reveal complex astronomical sources without a prior model. Among these complex objects are the young stars and their environments, which have a typical morphology with a point-like source, surrounded by circumstellar material with unknown morphology. To image them, we have developed a numerical method that removes completely the stellar point source and reconstructs the rest of the image, using the differences in the spectral behavior between the star and its circumstellar material. We aim to reveal the first Astronomical Units of these objects where many physical phenomena could interplay: the dust sublimation causing a puffed-up inner rim, a dusty halo, a dusty wind or an inner gaseous component. To investigate more deeply these regions, we carried out the first Large Program survey of HAeBe stars with two main goals: statistics on the geometry of these objects at the first astronomical unit scale and imaging their very close environment. The images reveal the environment, which is not polluted by the star and allows us to derive the best fit for the flux ratio and the spectral slope. We present the first images from this survey and the application of the imaging method on other astronomical objects.

Object-Location-Aware Hashing for Multi-Label Image Retrieval via Automatic Mask Learning.

PubMed

Huang, Chang-Qin; Yang, Shang-Ming; Pan, Yan; Lai, Han-Jiang

2018-09-01

Learning-based hashing is a leading approach of approximate nearest neighbor search for large-scale image retrieval. In this paper, we develop a deep supervised hashing method for multi-label image retrieval, in which we propose to learn a binary "mask" map that can identify the approximate locations of objects in an image, so that we use this binary "mask" map to obtain length-limited hash codes which mainly focus on an image's objects but ignore the background. The proposed deep architecture consists of four parts: 1) a convolutional sub-network to generate effective image features; 2) a binary "mask" sub-network to identify image objects' approximate locations; 3) a weighted average pooling operation based on the binary "mask" to obtain feature representations and hash codes that pay most attention to foreground objects but ignore the background; and 4) the combination of a triplet ranking loss designed to preserve relative similarities among images and a cross entropy loss defined on image labels. We conduct comprehensive evaluations on four multi-label image data sets. The results indicate that the proposed hashing method achieves superior performance gains over the state-of-the-art supervised or unsupervised hashing baselines.

Low Discretionary Time as a Barrier to Physical Activity and Intervention Uptake

ERIC Educational Resources Information Center

Wolin, Kathleen Y.; Bennett, Gary G.; McNeill, Lorna H.; Sorensen, Glorian; Emmons, Karen M.

2008-01-01

Objective: To determine whether self-reported discretionary time was associated with physical activity and uptake of a physical activity promotion intervention in a multi-ethnic urban sample. Methods: We examined the association of self-reported discretionary time with hours/week of leisure-time physical activity at baseline and physical activity…

Many-Objective Reservoir Policy Identification and Refinement to Reduce Institutional Myopia in Water Management

NASA Astrophysics Data System (ADS)

Giuliani, M.; Herman, J. D.; Castelletti, A.; Reed, P. M.

2013-12-01

Institutional inertia strongly limits our ability to adapt water reservoir operations to better manage growing water demands as well as their associated uncertainties in a changing climate. Although it has long been recognized that these systems are generally framed in heterogeneous socio-economic contexts involving a myriad of conflicting, non-commensurable operating objectives, our broader understanding of the multiobjective consequences of current operating rules as well as their vulnerability to hydroclimatic uncertainties is severely limited. This study proposes a decision analytic framework to overcome policy inertia and myopia in complex river basin management contexts. The framework combines reservoir policy identification and many-objective optimization under uncertainty to characterize current operations and discover key tradeoffs between alternative policies for balancing evolving demands and system uncertainties. The approach is demonstrated on the Conowingo Dam, located within the Lower Susquehanna River, USA. The Lower Susquehanna River is an interstate water body that has been subject to intensive water management efforts due to the system's competing demands from urban water supply, atomic power plant cooling, hydropower production, and federally regulated environmental flows. Initially our proposed framework uses available streamflow observations to implicitly identify the Conowingo Dam's current but unknown operating policy. This baseline policy is identified by fitting radial basis functions to existing system dynamics. Our assumption in the baseline policy is that the dam operator is represented as a rational agent seeking to maximize primary operational objectives (i.e., guaranteeing the public water supply and maximizing the hydropower revenue). The quality of the identified baseline policy is evaluated by its ability to replicate historical release dynamics. Once identified, the historical baseline policy then provides a means of representing the decision preferences guiding current operations. Our results show that the estimated policy closely captures the dynamics of current releases and flows for the Lower Susquehanna. After identifying the historical baseline policy, our proposed decision analytic framework then combines evolutionary many-objective optimization with visual analytics to discover improved operating policies. Our Lower Susquehanna results confirm that the system's current history-based operations are negatively biased to overestimate the reliability of the reservoir's multi-sector services. Moreover, our proposed framework has successfully identified alternative reservoir policies that are more robust to hydroclimatic uncertainties while being capable of better addressing the tradeoffs across the Conowingo Dam's multi-sector services.

Computer simulations of interferometric imaging with the VLT Interferometer and the AMBER instrument

NASA Astrophysics Data System (ADS)

Bloecker, Thomas; Hofmann, Karl-Heinz; Przygodda, Frank; Weigelt, Gerd

2000-07-01

We present computer simulations of interferometric imaging with the VLT interferometer and the AMBER instrument. These simulations include both the astrophysical modeling of a stellar object by radiative transfer calculations and the simulation of light propagation from the object to the detector (through atmosphere, telescopes, and the AMBER instrument), simulation of photon noise and detector read- out noise, and finally data processing of the interferograms. The results show the dependence of the visibility error bars on the following observational parameters: different seeing during the observation of object and reference star (Fried parameters r0,object equals 2.4 m, r0,ref. equals 2.5 m), different residual tip- tilt error ((delta) tt,object equals 2% of the Airy disk diameter, (delta) tt,ref. equals 0.1%), and object brightness (Kobject equals 3.5 mag and 11 mag, Kref. equals 3.5 mag). Exemplarily, we focus on stars in late stages of stellar evolution and study one of its key objects, the dusty supergiant IRC + 10420 that is rapidly evolving on human timescales. We show computer simulations of VLTI interferometry of IRC + 10420 with two ATs (wide-field mode, i.e. without fiber optics spatial filters) and discuss whether the visibility accuracy is sufficient to distinguish between different theoretical model predictions.

Predicting child maltreatment among Puerto Rican children from migrant and non-migrant families

PubMed Central

Sledjeski, Eve M.; Dierker, Lisa C.; Bird, Hector R.; Canino, Glorisa

2009-01-01

Objective The objectives of the present study were to 1) describe the prevalence of child maltreatment among migrant and non-migrant Puerto Rican families and 2) identify socio-demographic and cultural (i.e. acculturation pattern, familismo) predictors of maltreatment within these two samples. Method Representative community samples of Puerto Rican children (ages 5-13 at baseline) and their adult caretakers were interviewed at two sites: the South Bronx in New York City (n=631 families) and the Standard Metropolitan Areas of San Juan and Caguas in Puerto Rico (n=859 families). Participants were re-interviewed one and two years following the baseline assessment. Results While prevalence rates of maltreatment (physical abuse, 10%; sexual abuse 1 %; neglect, 10%; and multi-type, 6%) did not differ between the two sites at baseline assessment, site differences emerged over time. Rates of physical abuse at follow-up were significantly higher in the Bronx compared to Puerto Rico. Further, for families living in the Bronx, living in poverty predicted chronic maltreatment, whereas living above the poverty line predicted new cases of maltreatment at follow-up. For families living in Puerto Rico, those who experienced physical abuse or multi-type maltreatment at baseline were more likely to report chronic maltreatment at follow-up regardless of poverty level. Cultural factors were not related to baseline or follow-up maltreatment at either site. Conclusion Findings suggest that while rates of child maltreatment may be similar in migrant and non-migrant Puerto Rican families and when compared to prevalence rates in the US, predictors of maltreatment may differ. Practice Implications Since predictors of maltreatment may vary across population subgroups, studying homogenous samples will lead to more effective and targeted interventions. PMID:19457554

Robust design of multiple trailing edge flaps for helicopter vibration reduction: A multi-objective bat algorithm approach

NASA Astrophysics Data System (ADS)

Mallick, Rajnish; Ganguli, Ranjan; Seetharama Bhat, M.

2015-09-01

The objective of this study is to determine an optimal trailing edge flap configuration and flap location to achieve minimum hub vibration levels and flap actuation power simultaneously. An aeroelastic analysis of a soft in-plane four-bladed rotor is performed in conjunction with optimal control. A second-order polynomial response surface based on an orthogonal array (OA) with 3-level design describes both the objectives adequately. Two new orthogonal arrays called MGB2P-OA and MGB4P-OA are proposed to generate nonlinear response surfaces with all interaction terms for two and four parameters, respectively. A multi-objective bat algorithm (MOBA) approach is used to obtain the optimal design point for the mutually conflicting objectives. MOBA is a recently developed nature-inspired metaheuristic optimization algorithm that is based on the echolocation behaviour of bats. It is found that MOBA inspired Pareto optimal trailing edge flap design reduces vibration levels by 73% and flap actuation power by 27% in comparison with the baseline design.

Resolving the dusty circumstellar environment of the A[e] supergiant HD 62623 with the VLTI/MIDI

NASA Astrophysics Data System (ADS)

Meilland, Antony; Kanaan, Sameer; Fernandes, Marcelo Borges; Chesneau, Olivier; Millour, Florentin; Stee, Philippe; Lopez, Bruno

2011-07-01

HD 62623 is one of the very few A-type supergiants showing the B[e] phenomenon. We studied the geometry of its circumstellar envelope in the mid-infrared using the VLTI/MIDI instrument. Using the radiative transfer code MC3D, we managed to model it as a dusty disk with an inner radius of 3.85 AU, an inclination angle of 60°, and a mass of 2 × 10-7Msolar. It is the first time that the dusty disk inner rim of a supergiant star exhibiting the B[e] phenomenon is significantly constrained. The inner gaseous envelope likely contributes up to 20% to the total N band flux and acts like a reprocessing disk. Finally, the hypothesis of a stellar wind deceleration by the companion gravitational effect remains the most probable case since the bi-stability mechanism is not efficient for this star.

Les Noyaux Actifs de Galaxies en interférométrie optique à très longue base - Projet 'OHANA

NASA Astrophysics Data System (ADS)

Woillez, Julien

2003-12-01

Recent progress in sensitivity achieved by the new generation of optical long baseline interfero- meters (VLTI & Keck) allows new fields of astronomy to benefit from very high angular resolution observations at near infrared wavelength. Extragalactic astronomy, through active galactic nuclei observations, is one of those fields. As a preparation to coming active nuclei interferometric observations, I present a toolbox designed for the in- terpretation of the first data, knowing that their amount will stay small at the beginning whereas the observed objects are known to be complex. I will also present one of the two first observations of active nuclei : the Seyfert 2 nucleus NGC 1068 observed with MIDI, the newly commissioned 10 μm instrument of the VLTI. With the Seyfert 1 nucleus NGC 4151 by Keck interferometer, those two observations confirm the forecasted need of higher angular resolution to study the inner parts of the molecular torus found in active galactic nuclei. The broad line region will be one of the next components to be observed with an interferometer, provided that the extra angular resolution becomes available. In order to study the 3D structure of the region, I present an innovative tomographic technique based on reverberation mapping and interferometry : interferometric reverberation. The 'OHANA project (Optical Hawaiian Array for Nanoradion Astronomy) is the topic of the second part of this work as it will provide the extra angular resolution. The project also aims at demonstrating the use of single mode fibers in J, H and K bands to coherently combine adaptive corrected telescopes, already present on top of Mauna Kea, into a very sensitive and resolving interferometer. I present the preparatory phase of the project (Phase I) where the coupling between adaptive optics and single mode fibers is studied on CFHT, Gemini and Keck telescopes. Those tests allow me to confirm the sensitivity of the final instrument as well as to propose a diagnostic on the different adaptive optics systems. Then I present the 'OHANA beam combiner that is about to be used in the demonstration phase (phase II). This combiner is based on a new concept where the two interferometric outputs of a single mode coaxial combination are combined in a multiaxial scheme in order to obtain a single output, with only one coupler. The interferogram is then temporally coded and the photometry spatially. I present the ongoing developments of pahse II, namely a gaussian beam delay line and 2×300 m long single mode fibers, in J, H and K bands, used for the coherent transport.

Resolved astrometric orbits of ten O-type binaries

NASA Astrophysics Data System (ADS)

Le Bouquin, J.-B.; Sana, H.; Gosset, E.; De Becker, M.; Duvert, G.; Absil, O.; Anthonioz, F.; Berger, J.-P.; Ertel, S.; Grellmann, R.; Guieu, S.; Kervella, P.; Rabus, M.; Willson, M.

2017-05-01

Aims: Our long-term aim is to derive model-independent stellar masses and distances for long period massive binaries by combining apparent astrometric orbit with double-lined radial velocity amplitudes (SB2). Methods: We followed-up ten O+O binaries with AMBER, PIONIER and GRAVITY at the VLTI. Here, we report on 130 astrometric observations over the last seven years. We combined this dataset with distance estimates to compute the total mass of the systems. We also computed preliminary individual component masses for the five systems with available SB2 radial velocities. Results: Nine of the ten binaries have their three-dimensional orbit well constrained. Four of them are known to be colliding wind, non-thermal radio emitters, and thus constitute valuable targets for future high angular resolution radio imaging. Two binaries break the correlation between period and eccentricity tentatively observed in previous studies. This suggests either that massive star formation produces a wide range of systems, or that several binary formation mechanisms are at play. Finally, we found that the use of existing SB2 radial velocity amplitudes can lead to unrealistic masses and distances. Conclusions: If not understood, the biases in radial velocity amplitudes will represent an intrinsic limitation for estimating dynamical masses from SB2+interferometry or SB2+Gaia. Nevertheless, our results can be combined with future Gaia astrometry to measure the dynamical masses and distances of the individual components with an accuracy of 5 to 15%, completely independently of the radial velocities. Based on observations collected with the PIONIER/VLTI, AMBER/VLTI and GRAVITY/VLTI instruments at the European Southern Observatory, Paranal, under programs 087.C-0458, 087.D-0150, 087.D-0264, 090.D-0036, 090.D-0291, 090.D-0600, 091.D-0087, 091.D-0334, 092.C-0243, 092.C-0542, 092.D-0015, 092.D-0366, 092.D-0590, 092.D-0647, 093.C-0503, 093.D-0039, 093.D-0040, 093.D-0673, 094.C-0397, 094.C-0884, 189.C-0644, 60.A-9168, 096.D-0114.The list of astrometric positions is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/601/A34

Embedded AGN and star formation in the central 80 pc of IC 3639

NASA Astrophysics Data System (ADS)

Fernández-Ontiveros, J. A.; Tristram, K. R. W.; Hönig, S.; Gandhi, P.; Weigelt, G.

2018-03-01

Aims: Our goal is to probe the inner structure and the nature of the mid-IR emission in the active galaxy IC 3639, which hosts a Seyfert 2 nucleus and shows signatures of strong star-forming activity. Methods: We used interferometric observations in the N-band with VLTI/MIDI to resolve the mid-IR emission of this nucleus. The origin of the nuclear infrared emission is determined from: (1) the comparison of the correlated fluxes from VLTI/MIDI with the fluxes measured at subarcsecond resolution (VLT/VISIR, VLT/ISAAC); (2) diagnostics based on IR fine-structure line ratios, the IR continuum emission, IR bands produced by polycyclic aromatic hydrocarbons (PAH) and silicates; and (3) the high-angular resolution spectral energy distribution. Results: A large fraction of the total mid-IR emission of IC 3639 is produced in the innermost ≲80 pc with only 1% of the total luminosity released in the UV/optical range. The unresolved flux of IC 3639 is 90 ± 20 mJy at 10.5 μm, measured with three different baselines in VLTI (UT1-UT2, UT3-UT4, and UT2-UT3; 46-58 m), making this the faintest measurement so far achieved with mid-IR interferometry. The correlated flux is a factor of 3-4 times fainter than the VLT/VISIR total flux measurement. The observations suggest that most of the mid-IR emission has its origin on spatial scales between 10 and 80 pc (40-340 mas). The emission confined within the inner 80 pc is either dominated by a starburst component or by the AGN core. The brightness distribution could be reproduced by a single component associated with the AGN, although this scenario would imply a very extended dust distribution when compared to other nearby Seyfert galaxies detected with MIDI. The extended component could also be associated with polar dust emission, that is, with a dusty wind blown by the AGN. However, a mixed contribution dominated by the star formation component over the AGN is favoured by the diagnostics based on ratios of IR fine-structure emission lines, the shape of the IR continuum, and the PAH and silicate bands. Conclusions: A composite AGN-starburst scenario is able to explain both the mid-IR brightness distribution and the IR spectral properties observed in the nucleus of IC 3639. The nuclear starburst would dominate the mid-IR emission and the ionisation of low-excitation lines (e.g. [Ne II]12.8 μm) with a net contribution of 70%. The AGN accounts for the remaining 30% of the mid-IR flux, ascribed to the unresolved component in the MIDI observations, and the ionisation of high-excitation lines (e.g. [Ne V]14.3 μm and [O IV]25.9 μm). Based on observations collected at the European Southern Observatory, Chile, programmes 070.B-0393, 088.D-0005 and 088.B-0809.

Multi-project baselines for potential clean development mechanism projects in the electricity sector in South Africa

DOE Office of Scientific and Technical Information (OSTI.GOV)

Winkler, H.; Spalding-Fecher, R.; Sathaye, J.

2002-06-26

The United Nations Framework Convention on Climate Change (UNFCCC) aims to reduce emissions of greenhouse gases (GHGs) in order to ''prevent dangerous anthropogenic interference with the climate system'' and promote sustainable development. The Kyoto Protocol, which was adopted in 1997 and appears likely to be ratified by 2002 despite the US withdrawing, aims to provide means to achieve this objective. The Clean Development Mechanism (CDM) is one of three ''flexibility mechanisms'' in the Protocol, the other two being Joint Implementation (JI) and Emissions Trading (ET). These mechanisms allow flexibility for Annex I Parties (industrialized countries) to achieve reductions by extra-territorialmore » as well as domestic activities. The underlying concept is that trade and transfer of credits will allow emissions reductions at least cost. Since the atmosphere is a global, well-mixed system, it does not matter where greenhouse gas emissions are reduced. The CDM allows Annex I Parties to meet part of their emissions reductions targets by investing in developing countries. CDM projects must also meet the sustainable development objectives of the developing country. Further criteria are that Parties must participate voluntarily, that emissions reductions are ''real, measurable and long-term'', and that they are additional to those that would have occurred anyway. The last requirement makes it essential to define an accurate baseline. The remaining parts of section 1 outline the theory of baselines, emphasizing the balance needed between environmental integrity and reducing transaction costs. Section 2 develops an approach to multi-project baseline for the South African electricity sector, comparing primarily to near future capacity, but also considering recent plants. Five potential CDM projects are briefly characterized in section 3, and compared to the baseline in section 4. Section 5 concludes with a discussion of options and choices for South Africa regarding electricity sector baselines.« less

A Milestone for the VLT Interferometer

NASA Astrophysics Data System (ADS)

2000-10-01

Less than one month after "First Light" for the fourth 8.2-m YEPUN telescope ( ESO PR 18/00 ), another special moment occurred at ESO's Paranal Observatory. This time, it was the first truly "underground" event, in the 168-metre long Interferometric Tunnel that has been dug beneath the platform at the top of the mountain. As one staff member remarked on this occasion, it was something like "the first scheduled trip of the Paranal metro"! With the successful integration of the first Delay Line on Monday, September 25th, 2000, ESO has accomplished another important step towards the VLT Interferometer (VLTI). It will be followed by the integration of the second Delay Line by the end of November and the third is scheduled for February 2001; both are now in their final development phase in Europe. "VLTI First Light" is then expected to take place soon thereafter, by means of two small special telescopes ("siderostats"). The combination of the light beams from two of the 8.2-m Unit Telescopes will happen in mid-2001. The VLTI Delay Lines The VLTI Delay Lines form essential parts of this very complicated optical system. They serve to ensure that the light beams from several telescopes arrive in phase at the common interferometric focus. Details about how they function may be found in ESO PR 04/98. In order to achieve the necessary performance, ESO has worked with two Dutch contractors, Fokker Space and TNO-TPD - Netherlands Organization for Applied Scientific Research - Institute of Applied Physics , to arrive at a totally new Delay Line concept. Another Dutch participant in the VLTI project is the Nova-ESO VLTI Expertise Centre (NEVEC) , cf. ESO PR 14/00. The installation at Paranal The last twelve months have been very busy for the integration team, with much preparatory work at the VLTI buildings for the final installation of the Delay Line systems. The assembly of the translation mechanisms for the first two Delay Lines in the tunnel started in mid-2000. This included the alignment of their rails and supports to the extreme accuracy of about 0.25 mm over a total distance of 66.7 metres ( PR Photos 26a-b/00 ). To achieve such an unusually high precision, ESO - in collaboration with the French company FOGALE - developed a measurement system that is based on the water-level principle. The delicate assembly and alignment of the critical sub-systems of the Delay Line were undertaken with the support of Fokker Space and TPD/TNO ( PR Photo 26e/00 ). Also for this, state-of-the-art methods were required in order to ensure a stringent performance of the system. This includes optical alignment of the optics with an accuracy at the arcsec level and positioning of the linear motors at the 0.01 mm (10 µm) level. The Delay Line is one of the key systems in the VLT Interferometer. It is responsible for the compensation of the length of the optical path that is different from the individual telescopes. Extreme accuracy needed In the case of the VLT, this accuracy of the path length compensation must be within a tolerance of only 0.05 µm (0.00005 mm) over a distance of 120 metres. The present concept by ESO and the Dutch contractors is based on a retro-reflector (a "Cat's Eye") that is fixed on a carriage that runs on two stainless steel rails ( PR Photos 26c-d/00 ). The motion on these rails is performed by a 60 metres linear motor and a piezo-transducer element. They are controlled by a laser metrology system that measures the instantaneous distances betwen the mirrors with the required accuracy. This carriage is 2.5 metres long and weighs 250 kg. The total friction force is less than 50 grammes, thanks to the extreme accuracy of the rail alignment and special ball bearings. Because of this, the total power required for the Delay Line operation is only about 15 W. The mirrors of the retro-reflector are made of aluminium by REOSC (France). They have been coated with a single layer of gold for the best possible reflection at infrared wavelengths. This is the caption to ESO PR Photos 26a-e/00 . They may be reproduced, if credit is given to the European Southern Observatory. Note, however, that since these photos were electronically recorded and were primarily obtained to document the ongoing activities at Paranal, they are not of full professional quality for photographic reproduction.

The twofold debris disk around HD 113766 A. Warm and cold dust as seen with VLTI/MIDI and Herschel/PACS

NASA Astrophysics Data System (ADS)

Olofsson, J.; Henning, Th.; Nielbock, M.; Augereau, J.-C.; Juhàsz, A.; Oliveira, I.; Absil, O.; Tamanai, A.

2013-03-01

Context. Warm debris disks are a sub-sample of the large population of debris disks, and display excess emission in the mid-infrared. Around solar-type stars, very few objects (~2% of all debris disks) show emission features in mid-IR spectroscopic observations that are attributed to small, warm silicate dust grains. The origin of this warm dust could be explained either by a recent catastrophic collision between several bodies or by transport from an outer belt similar to the Kuiper belt in the solar system. Aims: We present and analyze new far-IR Herschel/PACS photometric observations, supplemented by new and archival ground-based data in the mid-IR (VLTI/MIDI and VLT/VISIR), for one of these rare systems: the 10-16 Myr old debris disk around HD 113766 A. We improve an existing model to account for these new observations. Methods: We implemented the contribution of an outer planetesimal belt in the Debra code, and successfully used it to model the spectral energy distribution (SED) as well as complementary observations, notably MIDI data. We better constrain the spatial distribution of the dust and its composition. Results: We underline the limitations of SED modeling and the need for spatially resolved observations. We improve existing models and increase our understanding of the disk around HD 113766 A. We find that the system is best described by an inner disk located within the first AU, well constrained by the MIDI data, and an outer disk located between 9-13 AU. In the inner dust belt, our previous finding of Fe-rich crystalline olivine grains still holds. We do not observe time variability of the emission features over at least an eight-year time span in an environment subjected to strong radiation pressure. Conclusions: The time stability of the emission features indicates that μm-sized dust grains are constantly replenished from the same reservoir, with a possible depletion of sub- μm-sized grains. We suggest that the emission features may arise from multi-composition aggregates. We discuss possible scenarios concerning the origin of the warm dust observed around HD 113766 A. The compactness of the innermost regions as probed by the MIDI visibilities and the dust composition suggest that we are witnessing the results of (at least) one collision between partially differentiated bodies, in an environment possibly rendered unstable by terrestrial planetary formation. Based on Herschel observations, OBSIDs: 1342227026, 1342227027, 1342237934, and 1342237935. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA. Based on VISIR observations collected at the VLT (European Southern Observatory, Paranal, Chile) with program 089.C-0322(A).

Mid-infrared interferometry towards the massive young stellar object CRL 2136: inside the dust rim

NASA Astrophysics Data System (ADS)

de Wit, W. J.; Hoare, M. G.; Oudmaijer, R. D.; Nürnberger, D. E. A.; Wheelwright, H. E.; Lumsden, S. L.

2011-02-01

Context. Establishing the importance of circumstellar disks and their properties is crucial to fully understand massive star formation. Aims: We aim to spatially resolve the various components that make-up the accretion environment of a massive young stellar object (⪉100 AU), and reproduce the emission from near-infrared to millimeter wavelengths using radiative transfer codes. Methods: We apply mid-infrared spectro-interferometry to the massive young stellar object CRL 2136. The observations were performed with the Very Large Telescope Interferometer and the MIDI instrument at a 42 m baseline probing angular scales of 50 milli-arcseconds. We model the observed visibilities in parallel with diffraction-limited images at both 24.5 μm and in the N-band (with resolutions of 0.6´´and 0.3´´, respectively), as well as the spectral energy distribution. Results: The arcsec-scale spatial information reveals the well-resolved emission from the dusty envelope. By simultaneously modelling the spatial and spectral data, we find that the bulk of the dust emission occurs at several dust sublimation radii (approximately 170 AU). This reproduces the high mid-infrared fluxes and at the same time the low visibilities observed in the MIDI data for wavelengths longward of 8.5 μm. However, shortward of this wavelength the visibility data show a sharp up-turn indicative of compact emission. We discuss various potential sources of this emission. We exclude a dust disk being responsible for the observed spectral imprint on the visibilities. A cool supergiant star and an accretion disk are considered and both shown to be viable origins of the compact mid-infrared emission. Conclusions: We propose that CRL 2136 is embedded in a dusty envelope, which truncates at several times the dust sublimation radius. A dust torus is manifest in the equatorial region. We find that the spectro-interferometric N-band signal can be reproduced by either a gaseous disk or a bloated central star. If the disk extends to the stellar surface, it accretes at a rate of 3.0 × 10-3 M⊙ yr-1. Based on observations with the VLTI, proposal 381.C-0607.

VizieR Online Data Catalog: NGC1068 interferometric mid-IR measurements (Lopez-Gonzaga+, 2017)

NASA Astrophysics Data System (ADS)

Lopez-Gonzaga, N.; Asmus, D.; Bauer, F. E.; Tristram, K. R. W.; Burtscher, L.; Marinucci, A.; Matt, G.; Harrison, F. A.

2017-06-01

Single-aperture mid-infrared images and spectra were taken with the VLT spectrometer and imager for the mid-infrared (VISIR). Interferometric measurements were obtained with the instrument MIDI at the ESO's VLTI facility. Observations with intermediate AT baselines were requested and observed during the nights of January, 10, 20, and 23, 2015 using Director's discretionary time (DDT). We additionally included published and unpublished interferometric data from our previous campaigns with the requirement that they were observed (nearly) contemporaneously to the period of X-ray variation or observed a few years before. These include observations taken on the nights of September, 21, 26, and 30, 2014, and November, 17, 2014, using Guaranteed Time Observations (GTO). For our observations we used the low-resolution NaCl prism with spectral resolution R=λ/Δλ~30 to disperse the light of the beams. A log of the observations and instrument setup can be found in Appendix A. The published data were taken from Lopez-Gonzaga et al. (2014A&A...565A..71L, Cat. J/A+A/565/A71). (2 data files).

Interferometric observations of main-sequence stars: fundamental stellar astrophysics, circumstellar matter, and kinematics

NASA Astrophysics Data System (ADS)

Bakker, Eric J.; Eiroa, Carlos

2003-10-01

With our minds focussed on the direct detection of planets using the space interferometry mission DARWIN/TPF, we have made an attempt to identify how the set of ESO Very Large Telescope Interferometer instruments available now, and in the near future (VINCI, MIDI, AMBER, GENIE, FINITO and PRIMA) could contribute to the DARWIN/TPF precursory science program. In particular related to the identification of a short list of science stars to be observed with DARWIN/TPF. We have identified two research projects which can be viewed as DARWIN/TPF precursory science and can be embarked upon shortly using the available VLTI instruments: (1) the direct measurement of stellar angular diameters of a statistically meaningful sample of main-sequence stars with AMBER; (2) an interferometric study of those main-sequence stars that exhibit an infrared excess with either AMBER or MIDI. On the longer run, VLTI can obviously make a significant impact through the exploitation of the infrared nuller GENIE and the astrometric facility PRIMA.

Optical alignment of the VLTI

NASA Astrophysics Data System (ADS)

Guisard, Stephane

2003-02-01

When completed the VLTI project will be composed by four 8.2 m Unit Telescopes (UT) and four 1.8 m Auxiliay Telescopes (AT) with their respective Coude trains and relay optics, two test siderostats, 6 (up to 8) Delay lines and 8 Beam compressors with their corresponding feeding mirrors. There will be more than 200 optical components, mirrors and lenses, with diameters ranging from 5 mm to 8200 mm. Their surface shapes range from flat to off-axis ellipsoid, including also spherical, on and off-axis hyperbolae and parabolas as well as cylindrical surfaces. Depending on the interferometer configuration, the different possible optical path lengths are of the order of 100 to 300 meters. We describe briefly the principles chosen as well as the types of criteria and method used for the alignment. The method can certainly be applied to other optical systems. The explanations given are understandable to the non-optician, this text is not intended to be an alignment procedure.

The SDSS-III Multi-object Apo Radial-velocity Exoplanet Large-area Survey

NASA Astrophysics Data System (ADS)

Ge, Jian; Mahadevan, S.; Lee, B.; Wan, X.; Zhao, B.; van Eyken, J.; Kane, S.; Guo, P.; Ford, E. B.; Agol, E.; Gaudi, S.; Fleming, S.; Crepp, J.; Cohen, R.; Groot, J.; Galvez, M.; Liu, J.; Ford, H.; Schneider, D.; Seager, S.; Hawley, S. L.; Weinberg, D.; Eisenstein, D.

2007-12-01

As part of SDSS-III survey in 2008-2014, the Multi-object APO Radial-Velocity Exoplanet Large-area Survey (MARVELS) will conduct the largest ground-based Doppler planet survey to date using the SDSS telescope and new generation multi-object Doppler instruments with 120 object capability and 10-20 m/s Doppler precision. The baseline survey plan is to monitor a total of 11,000 V=8-12 stars ( 10,000 main sequence stars and 1000 giant stars) over 800 square degrees over the 6 years. The primary goal is to produce a large, statistically well defined sample of giant planets ( 200) with a wide range of masses ( 0.2-10 Jupiter masses) and orbits (1 day-2 years) drawn from a large of host stars with a diverse set of masses, compositions, and ages for studying the diversity of extrasolar planets and constraining planet formation, migration & dynamical evolution of planetary systems. The survey data will also be used for providing a statistical sample for theoretical comparison and discovering rare systems and identifying signposts for lower-mass or more distant planets. Early science results from the pilot program will be reported. We would like to thank the SDSS MC for allocation of the telescope time and the W.M. Keck Foundation, NSF, NASA and UF for support.

Sleep Duration and Quality in Relation to Autonomic Nervous System Measures: The Multi-Ethnic Study of Atherosclerosis (MESA)

PubMed Central

Castro-Diehl, Cecilia; Diez Roux, Ana V.; Redline, Susan; Seeman, Teresa; McKinley, Paula; Sloan, Richard; Shea, Steven

2016-01-01

Study Objectives: Short sleep duration and poor sleep quality are associated with adverse cardiovascular outcomes. Potential pathophysiological mechanisms include sleep-associated alterations in the autonomic nervous system. The objective of this study was to examine the associations of shorter sleep duration and poorer sleep quality with markers of autonomic tone: heart rate (HR), high-frequency HR variability (HF-HRV) and salivary amylase. Methods: Cross-sectional analysis of data from actigraphy-based measures of sleep duration and efficiency and responses to a challenge protocol obtained from 527 adult participants in the Multi-Ethnic Study of Atherosclerosis. Results: Participants who slept fewer than 6 h per night (compared to those who slept 7 h or more per night) had higher baseline HR (fully adjusted model 0.05 log beats/min, 95% confidence interval [CI] 0.01, 0.09) and greater HR orthostatic reactivity (fully adjusted model 0.02 log beats/min, 95% CI 0.002, 0.023). Participants who slept 6 to less than 7 h/night (compared to those who slept 7 h or more per night) had lower baseline HF-HRV (fully adjusted model −0.31 log msec2, 95% CI −0.60, −0.14). Participants with low sleep efficiency had lower baseline HF-HRV than those with higher sleep efficiency (fully adjusted model −0.59 log msec2, 95% CI −1.03, −0.15). Participants with low sleep efficiency had higher baseline levels of amylase than those with higher sleep efficiency (fully adjusted model 0.45 log U/mL, 95% CI 0.04, 0.86). Conclusions: Short sleep duration, low sleep efficiency, and insomnia combined with short sleep duration were associated with markers of autonomic tone that indicate lower levels of cardiac parasympathetic (vagal) tone and/or higher levels of sympathetic tone. Citation: Castro-Diehl C, Roux AV, Redline S, Seeman T, McKinley P, Sloan R, Shea S. Sleep duration and quality in relation to autonomic nervous system measures: the Multi-Ethnic Study of Atherosclerosis (MESA). SLEEP 2016;39(11):1927–1940. PMID:27568797

On the morphology of the compact dust shell in the symbiotic system HM Sagittae

NASA Astrophysics Data System (ADS)

Sacuto, S.; Chesneau, O.

2009-01-01

Context: The symbiotic system HM Sagittae consists of a Mira star and a secondary White Dwarf component. The dust content of the system was severely affected by the nova outburst in 1975, which is still ongoing. The capabilities of optical interferometry operating in the mid-IR allow us to investigate the current geometry of the dust envelope. Aims: We test our previous spectro-interferometric study of this system with new interferometric configurations, increasing the uv coverage and allowing us to ascertain the appearance of the source between 8 and 13 μm. Methods: We used the MIDI instrument of the VLTI with the unit telescopes (UTs) and auxiliary telescopes (ATs) providing baselines oriented from PA = 42° to 127°. The data are interpreted by means of an elliptical Gaussian model and the spherical radiative transfer code DUSTY. Results: We demonstrate that the data can be reproduced well by an optically thick dust shell of amorphous silicate, typical of those encountered around Mira stars, whose measured dimension increases from 8 to 13 μm. We confirm that the envelope is more extended in a direction perpendicular to the binary axis. The level of elongation increases with wavelength in contrast to our claim in a previous study. Conclusions: The wider uv coverage allows us to deepen our previous investigations of the close circumstellar structure of this object. Based on observations made with the Very Large Telescope Interferometer at Paranal Observatory under programs 075.D-0484, 077.D-0216, and 079.D-0213. Reduced visibilities and differential phases are available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/493/1043

Prototyping and testing of mechanical components for the GRAVITY spectrometers

NASA Astrophysics Data System (ADS)

Wiest, Michael; Fischer, Sebastian; Thiel, Markus; Haug, Marcus; Rohloff, Ralf-Rainer; Straubmeier, Christian; Araujo-Hauck, Constanza; Yazici, Senol; Eisenhauer, Frank; Perrin, Guy; Brandner, Wolfgang; Perraut, Karine; Amorim, Antonio; Schöller, Markus; Eckart, Andreas

2010-07-01

GRAVITY is a 2nd generation VLTI Instrument which operates on 6 interferometric baselines by using all 4 UTs. It will offer narrow angle astrometry in the infrared K-band with an accuracy of 10 ìas. The University of Cologne is part of the international GRAVITY consortium and responsible for the design and manufacturing of the two spectrometers. One is optimized for observing the science object, providing three different spectral resolutions and optional polarimetry, the other is optimized for a fast fringe tracking at a spectral resolution of R=22 with optional polarimetry. In order to achieve the necessary image quality, the current mechanical design foresees 5 motorized functions, 2 linear motions and 3 filter wheels. Additionally the latest optical design proposal includes 20 degrees of freedom for manual adjustments distributed over the different optical elements. Both spectrometers require precise linear and rotational movements on micrometer or arcsecond scales. These movements will be realized using custom linear stages based on compliant joints. These stages will be driven by actuators based on a Phytron/Harmonic Drive combination. For dimensioning and in order to qualify the reliability of these mechanisms, it is necessary to evaluate the mechanisms on the base of several prototypes. Due to the cryogenic environment the wheel mechanisms will be driven by Phytron stepper motors, too. A ratchet mechanism, which is currently in the beginning of his design phase, will deliver the required precision to the filter wheels. This contribution will give a first impression how the next mechanical prototypes will look like. Besides, advantages of purchasing and integrating a distance sensor and a resolver are reported. Both are supposed to work under cryogenic conditions and should achieve high resolutions for the measuring of movements inside the test cryostat.

DISENTANGLING CONFUSED STARS AT THE GALACTIC CENTER WITH LONG-BASELINE INFRARED INTERFEROMETRY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stone, Jordan M.; Eisner, J. A.; Monnier, J. D.

2012-08-01

We present simulations of Keck Interferometer ASTRA and VLTI GRAVITY observations of mock star fields in orbit within {approx}50 mas of Sgr A*. Dual-field phase referencing techniques, as implemented on ASTRA and planned for GRAVITY, will provide the sensitivity to observe Sgr A* with long-baseline infrared interferometers. Our results show an improvement in the confusion noise limit over current astrometric surveys, opening a window to study stellar sources in the region. Since the Keck Interferometer has only a single baseline, the improvement in the confusion limit depends on source position angles. The GRAVITY instrument will yield a more compact andmore » symmetric point-spread function, providing an improvement in confusion noise which will not depend as strongly on position angle. Our Keck results show the ability to characterize the star field as containing zero, few, or many bright stellar sources. We are also able to detect and track a source down to m{sub K} {approx} 18 through the least confused regions of our field of view at a precision of {approx}200 {mu}as along the baseline direction. This level of precision improves with source brightness. Our GRAVITY results show the potential to detect and track multiple sources in the field. GRAVITY will perform {approx}10 {mu}as astrometry on an m{sub K} = 16.3 source and {approx}200 {mu}as astrometry on an m{sub K} = 18.8 source in 6 hr of monitoring a crowded field. Monitoring the orbits of several stars will provide the ability to distinguish between multiple post-Newtonian orbital effects, including those due to an extended mass distribution around Sgr A* and to low-order general relativistic effects. ASTRA and GRAVITY both have the potential to detect and monitor sources very close to Sgr A*. Early characterizations of the field by ASTRA, including the possibility of a precise source detection, could provide valuable information for future GRAVITY implementation and observation.« less

Tracing the potential planet-forming regions around seven pre-main-sequence stars

NASA Astrophysics Data System (ADS)

Schegerer, A. A.; Wolf, S.; Hummel, C. A.; Quanz, S. P.; Richichi, A.

2009-07-01

Aims: We investigate the nature of the innermost regions with radii of several AUs of seven circumstellar disks around pre-main-sequence stars, T Tauri stars in particular. Our object sample contains disks apparently at various stages of their evolution. Both single stars and spatially resolved binaries are considered. In particular, we search for inner disk gaps as proposed for several young stellar objects (YSOs). When analyzing the underlying dust population in the atmosphere of circumstellar disks, the shape of the 10 μm feature should additionally be investigated. Methods: We performed interferometric observations in N band (8-13 μm) with the Mid-Infrared Interferometric Instrument (MIDI) at the Very Large Telescope Interferometer (VLTI) using baseline lengths of between 54 m and 127 m. The data analysis is based on radiative-transfer simulations using the Monte Carlo code MC3D by modeling simultaneously the spectral energy distribution (SED), N band spectra, and interferometric visibilities. Correlated and uncorrelated N band spectra are compared to investigate the radial distribution of the dust composition of the disk atmosphere. Results: Spatially resolved mid-infrared (MIR) emission was detected in all objects. For four objects (DR Tau, RU Lup, S CrA N, and S CrA S), the observed N band visibilities and corresponding SEDs could be simultaneously simulated using a parameterized active disk-model. For the more evolved objects of our sample, HD 72106 and HBC 639, a purely passive disk-model provides the closest fit. The visibilities inferred for the source RU Lup allow the presence of an inner disk gap. For the YSO GW Ori, one of two visibility measurements could not be simulated by our modeling approach. All uncorrelated spectra reveal the 10 μm silicate emission feature. In contrast to this, some correlated spectra of the observations of the more evolved objects do not show this feature, indicating a lack of small silicates in the inner versus the outer regions of these disks. We conclude from this observational result that more evolved dust grains can be found in the more central disk regions. Based on observations made with Telescopes of the European Organisation for Astronomical Research in the Southern Hemisphere (ESO) at the Paranal Observatory, Chile, under the programs 074.C-0342(A), 075.C-0064(A,B), 075.C-0413(A,B), and 076.C-0356(A). Appendix A is only available in electronic form at http://www.aanda.org

Multi-objective Optimization of Departure Procedures at Gimpo International Airport

NASA Astrophysics Data System (ADS)

Kim, Junghyun; Lim, Dongwook; Monteiro, Dylan Jonathan; Kirby, Michelle; Mavris, Dimitri

2018-04-01

Most aviation communities have increasing concerns about the environmental impacts, which are directly linked to health issues for local residents near the airport. In this study, the environmental impact of different departure procedures using the Aviation Environmental Design Tool (AEDT) was analyzed. First, actual operational data were compiled at Gimpo International Airport (March 20, 2017) from an open source. Two modifications were made in the AEDT to model the operational circumstances better and the preliminary AEDT simulations were performed according to the acquired operational procedures. Simulated noise results showed good agreements with noise measurement data at specific locations. Second, a multi-objective optimization of departure procedures was performed for the Boeing 737-800. Four design variables were selected and AEDT was linked to a variety of advanced design methods. The results showed that takeoff thrust had the greatest influence and it was found that fuel burn and noise had an inverse relationship. Two points representing each fuel burn and noise optimum on the Pareto front were parsed and run in AEDT to compare with the baseline. The results showed that the noise optimum case reduced Sound Exposure Level 80-dB noise exposure area by approximately 5% while the fuel burn optimum case reduced total fuel burn by 1% relative to the baseline for aircraft-level analysis.

The Pregnancy in Polycystic Ovary Syndrome Study II: Baseline Characteristics and Effects of Obesity from a Multi-Center Randomized Clinical Trial

PubMed Central

Legro, Richard S.; Brzyski, Robert G.; Diamond, Michael P.; Coutifaris, Christos; Schlaff, William D.; Alvero, Ruben; Casson, Peter; Christman, Gregory M.; Huang, Hao; Yan, Qingshang; Haisenleder, Daniel J.; Barnhart, Kurt T.; Bates, G. Wright; Usadi, Rebecca; Lucidi, Richard; Baker, Valerie; Trussell, J.C.; Krawetz, Stephen A.; Snyder, Peter; Ohl, Dana; Santoro, Nanette; Eisenberg, Esther; Zhang, Heping

2014-01-01

Objective To summarize baseline characteristics from a large multi-center infertility clinical trial. Design Cross-sectional baseline data from a double-blind randomized trial of 2 treatment regimens (letrozole vs. clomiphene). Setting Academic Health Centers throughout the U.S. Interventions None Main Outcome Measure(s) Historical, biometric, biochemical and questionnaire parameters. Participants 750 women with PCOS and their male partners took part in the study. Results Females averaged ~30 years old and were obese (BMI 35) with ~20% from a racial/ethnic minority. Most (87%) were hirsute and nulligravid (63%). . Most of the females had an elevated antral follicle count and enlarged ovarian volume on ultrasound. Women had elevated mean circulating androgens, LH:FSH ratio (~2), and AMH levels (8.0 ng/mL). Additionally, women had evidence for metabolic dysfunction with elevated mean fasting insulin and dyslipidemia. Increasing obesity was associated with decreased LH:FSH levels, AMH levels and antral follicle counts but increasing cardiovascular risk factors, including prevalence of the metabolic syndrome. Males were obese (BMI 30) and had normal mean semen parameters. Conclusions The treatment groups were well-matched at baseline. Obesity exacerbates select female reproductive and most metabolic parameters. We have also established a database and sample repository that will eventually be accessible to investigators. PMID:24156957

Computer simulations of interferometric imaging with the Very Large Telescope Interferometer and its Astronomical Multibeam Recombiner instrument

NASA Astrophysics Data System (ADS)

Przygodda, Frank; Bloecker, Thomas; Hofmann, Karl-Heinz; Weigelt, Gerd

2001-05-01

We present computer simulations of interferometric imaging with the Very Large Telescope Interferometer (VLTI) of the European Southern Observatory and the Astronomical Multibeam Recombiner (AMBER) phase-closure instrument. These simulations include both the astrophysical modeling of a stellar object by radiative-transfer calculations and the simulation of light propagation from the object to the detector (through atmosphere, telescopes, and the AMBER instrument), simulation of photon noise and detector readout noise, and finally data processing of the interferograms. The results show the dependence of the visibility error bars on the following observational parameters: different seeing during the observation of object and reference star (Fried parameters r0,object and r0,ref ranging between 0.9 and 1.2 m), different residual tip-tilt error ((delta) tt,object and (delta) tt,ref ranging between 0.1% and 20% of the Airy-disk diameter), and object brightness (Kobject equals 0.7 to 10.2 mag, Kref equals 0.7 mag). As an example, we focus on stars in late stages of stellar evolution and study one of the key objects of that kind, the dusty super-giant IRC + 10420, which is rapidly evolving on human time scales. We show computer simulations of VLT interferometer (visibility and phase-closure measurements) of IRC + 10420 with two and three auxiliary telescopes (in AMBER wide-field mode, i.e., without fiber optic spatial filters) and discuss whether the visibility accuracy is sufficient to distinguish between different theoretical model predictions.

OVoG Inversion for the Retrieval of Agricultural Crop Structure by Means of Multi-Baseline Polarimetric SAR Interferometry

NASA Astrophysics Data System (ADS)

Pichierri, Manuele; Hajnsek, Irena

2015-04-01

In this work, the potential of multi-baseline Pol-InSAR for crop parameter estimation (e.g. crop height and extinction coefficients) is explored. For this reason, a novel Oriented Volume over Ground (OVoG) inversion scheme is developed, which makes use of multi-baseline observables to estimate the whole stack of model parameters. The proposed algorithm has been initially validated on a set of randomly-generated OVoG scenarios, to assess its stability over crop structure changes and its robustness against volume decorrelation and other decorrelation sources. Then, it has been applied to a collection of multi-baseline repeat-pass SAR data, acquired over a rural area in Germany by DLR's F-SAR.

The mid-IR and near-IR interferometry of AGNs: key results and their implications

NASA Astrophysics Data System (ADS)

Kishimoto, M.

2015-09-01

Infrared interferometry has been very productive in directly probing the structure of AGNs at sub-pc scales. With tens of objects already probed in the mid-IR and near-IR, I will summarize the key results and im- plications from this direct exploration. The Keck interferometry in the near-IR and VLTI in the mid-IR shaped the luminosity dependence of the torus size and structure, while the latter also revealed an equatorial structure at several Rsub (dust sublimation radius), and a polar-elongated region at a few tens of Rsub. Notably, this polar component seems to dominate the compact mid-IR flux. This component can persuasively be attributed to a polar outflow. However, interferometry, through emissivity estimations, also indicates that it is not a UV-optically-thin cloud but participating in the obscuration of the nucleus. I will discuss how to accommodate all these facts to build a consistent picture.

ESO and Fokker Space Sign Contract about VLTI Delay Line

NASA Astrophysics Data System (ADS)

1998-03-01

The European Southern Observatory is building the world's largest optical telescope, the Very Large Telescope (VLT) , at the ESO Paranal Observatory in Chile. The VLT consists of four 8.2-m unit telescopes and several smaller, moveable Auxiliary Telescopes. When coupled as the giant VLT Interferometer (VLTI) , they will together provide the sharpest images ever obtained by any optical telescope. It will in principle be able to see an astronaut on the surface of the Moon, 400,000 km away. The VLTI Delay Lines Fokker Space (Leiden, The Netherlands) has been awarded a contract for the delivery of the Delay Line of the VLTI. This is a mechanical-optical system that will compensate the optical path differences of the light beams from the individual telescopes. Such a system is necessary to ensure that the light from all telescopes arrive in the same phase at the focal point of the interferometer. Otherwise, the very sharp interferometric images cannot be obtained. ESO PR Photo 08/98 [JPEG, 102k] Schematic representation of the VLTI Delay Line, showing the retro-reflector on its moving base. For more details, please consult the technical explanation below. This highly accurate system will be developed in close co-operation with the Dutch institute TNO-TPD (Netherlands Organization for Applied Scientific Research - Institute of Applied Physics) . The most innovative feature of the Delay Line is the new control strategy, a two-stage control system, based on linear motor technology, combined with high accuracy piezo-electric control elements. This enables the system to position the so-called cat's eye reflector system with an accuracy of only a few nanometers (millionth of a millimetre (nm)) over a stroke length of 60 metres. Within radio astronomy, interferometric techniques have been applied by Dutch astronomers since many years. They will now be able to contribute with their extensive knowledge of such systems to the next generation of astronomical interferometric instruments within the present collaboration. About Fokker Space Fokker Space is the largest company in the Dutch space industry. It is based in Leiden, has 481 employees and an operating income of 220 million Netherlands Guilders in 1996. Fokker Space is mainly active in the field of solar arrays, launcher structures, thermal products, instruments and simulators. It also plays a key role in the development of robotics and is responsible as a prime contractor for the European Robotics Arm (ERA) to be used on the International Space Station. Fokker Space is well embedded in the Dutch aerospace infrastructure, thanks to close relations with the Dutch Space Agency (NIVR) , the National Aerospace Laboratory (NLR) , the Delft University of Technology and other Dutch space industries and institutes like TNO-TPD (Netherlands Organization for Applied Scientific Research - Institute of Applied Physics) . Fokker Space has also entered into strategic partnerships in Europe, Russia and North America. These facts, combined with the long lasting relation with the European Space Agency ESA and with the Dutch Government imply that Fokker Space has secured a solid base for continuation of its business far into the next millennium. Some technical details about the VLTI Delay Line The VLT Delay Line forms an essential part of the VLT Interferometer (VLTI) . It represents the current limit of high technology in this field and includes many innovative features. Some of the technical details are given below. In order to enable a useful combination of the light beams from the individual telescopes of the VLT (that is, to produce interferometric fringes at the focal point), the optical path length differences must be corrected by the Delay Line system. These differences are caused by: * the static geometric path length difference between the telescopes in a certain configuration; * the diurnal motion of the astronomical source during observation due to Earth's rotation; and * the rapid path length variations due to atmospheric disturbances and/or mechanical vibrations along the optical path length. The VLTI Delay Line system consists of a retro-reflector mounted on a moving base. The optical design of this `Cat's Eye' is of the Ritchey-Chretien type that reflects the light very effectively. For this particular application, the `Cat's Eye' is not a corner cube with 3 perpendicular mirrors as is the case in the reflectors on cars and bicycles; it is in fact a telescope with a mirror at the focus that sends a light beam back in a direction parallel to the one it came from. The moving base enables the Cat's Eye to travel along a 60 metres long rail track, thereby providing optical path difference corrections of up to 120 metres, as required for the VLT telescope configurations at Paranal. The necessary, rapid path length corrections are performed by a fine positioning loop in which a piezo crystal (mounted on the backside of the Variable Curvature Mirror M3) is used to correct the fast optical path variations as measured by a Fringe Sensing Unit (FSU). The latter provides a signal to the Delay Line system via a fast link to the Delay Line Local Control Unit. An optical datalink to the Cat's Eye on the carriage ensures the transfer of data to the Piezo controller. The carriage is driven by a Linear Induction Motor. The coils for the motor are mounted on the floor of the Delay Line Long Support Bench and the magnets are mounted on the bottom of the carriage. The metrology system (to measure the carriage position) consists of a laser-interferometer whose beam follows the same path as the light beams from the telescopes via the Cat's Eye. The main design parameters are shown here: Optical Path range above 120 m Optical Path resolution better than 20 nm Optical Path stability better than 14 nm over any 0.01 sec (in the visible spectral range) better than 50 nm over any 0.05 sec (in Near-IR spectral range) better than 225 nm over any 0.3 sec (in Thermal-IR spectral range) Absolute position repeatability 50 micron (over full length - 60 metres) 1 micron (over observation length - 3 metres) Maximum velocity: 0.5 m/sec Maximum velocity errors 1 micron/sec Maximum power dissipation 15 Watts Note: [1] This Press Release is issued jointly by ESO and Fokker Space on the occasion of the signature of the contract for the VLTI Delay System which takes place at Fokker Space in Leiden (The Netherlands) today. How to obtain ESO Press Information ESO Press Information is made available on the World-Wide Web (URL: http://www.eso.org ). ESO Press Photos may be reproduced, if credit is given to the European Southern Observatory.

Summary of the Conference "The Physics of Evolved Stars"

NASA Astrophysics Data System (ADS)

De Marco, O.

2015-12-01

Olivier Chesneau was an astronomer of many talents. His expertise was on optical and infrared interferometry. Olivier*s tool of choice, the Very Large Telescope Interferometer (VLTI), allowed him to see solutions to open questions in stellar astrophysics. These visions led to collaborations with experts in each of the fields where VLTI observations could be useful. As a result Olivier was a man in the middle of a phenomenal network of astronomers, collaborators and friends. I am fortunate to have been one of them. In this contribution I summarise the conference "Physics of Evolved Stars", held in Nice in June 2015 in memory of Olivier. The conference neatly showcased the science that Olivier had been involved with during his life and laid out the advancements that were made thanks in great part to him and to the collaborations he started. Without doubt his bubbly, happy personality, child-like in a way, made him the perfect connector bringing the technique, the questions and the experts in diverse fields together. Dear to all who worked with him, he was truly the little prince of Astronomy. We shall miss him every day.

Low vibration cooling using a pulse tube cooler and cryostat for the GRAVITY beam combiner instrument at the VLTI

NASA Astrophysics Data System (ADS)

Haug, M.; Haussmann, F.; Kellner, S.; Kern, L.; Eisenhauer, F.; Lizon, J.-L.; Dietrich, M.; Thummes, G.

2014-07-01

GRAVITY is a second generation VLTI instrument for high-precision narrow-angle astrometry and phase-referenced interferometric imaging in the astronomical K-band. The cryostat of the beam combiner instrument provides the required temperatures for the various subunits ranging from 40K to 290K with a milli-Kelvin temperature stability for some selected units. The bath cryostat is cooled with liquid nitrogen and makes use of the exhaust gas to cool the main optical bench to an intermediate temperature of 240K. The fringe tracking detector will be cooled separately by a single-stage pulse tube cooler to a temperature of 40K. The pulse tube cooler is optimized for minimum vibrations. In particular its warm side is connected to the 80K reservoir of the LN2 cryostat to minimize the required input power. All temperature levels are actively stabilized by electric heaters. The cold bench is supported separately from the vacuum vessel and the liquid nitrogen reservoir to minimize the transfer of acoustic noise onto the instrument.

First X-ray Statistical Tests for Clumpy Torii Models: Constraints from RXTE monitoring of Seyfert AGN

NASA Astrophysics Data System (ADS)

Markowitz, A.

2015-09-01

We summarize two papers providing the first X-ray-derived statistical constraints for both clumpy-torus model parameters and cloud ensemble properties. In Markowitz, Krumpe, & Nikutta (2014), we explored multi-timescale variability in line-of-sight X-ray absorbing gas as a function of optical classification. We examined 55 Seyferts monitored with the Rossi X-ray Timing Explorer, and found in 8 objects a total of 12 eclipses, with durations between hours and years. Most clouds are commensurate with the outer portions of the BLR, or the inner regions of infrared-emitting dusty tori. The detection of eclipses in type Is disfavors sharp-edged tori. We provide probabilities to observe a source undergoing an absorption event for both type Is and IIs, yielding constraints in [N_0, sigma, i] parameter space. In Nikutta et al., in prep., we infer that the small cloud angular sizes, as seen from the SMBH, imply the presence of >10^7 clouds in BLR+torus to explain observed covering factors. Cloud size is roughly proportional to distance from the SMBH, hinting at the formation processes (e.g. disk fragmentation). All observed clouds are sub-critical with respect to tidal disruption; self-gravity alone cannot contain them. External forces (e.g. magnetic fields, ambient pressure) are needed to contain them, or otherwise the clouds must be short-lived. Finally, we infer that the radial cloud density distribution behaves as 1/r^{0.7}, compatible with VLTI observations. Our results span both dusty and non-dusty clumpy media, and probe model parameter space complementary to that for short-term eclipses observed with XMM-Newton, Suzaku, and Chandra.

Probing the origin of UX Ori-type variability in the YSO binary CO Ori with VLTI/GRAVITY

NASA Astrophysics Data System (ADS)

Davies, C. L.; Kreplin, A.; Kluska, J.; Hone, E.; Kraus, S.

2018-03-01

The primary star in the young stellar object binary CO Ori displays UX Ori-type variability: irregular, high amplitude optical, and near-infrared photometric fluctuations where flux minima coincide with polarization maxima. This is attributed to changes in local opacity. In CO Ori A, these variations exhibit a 12.4 yr cycle. Here, we investigate the physical origin of the fluctuating opacity and its periodicity using interferometric observations of CO Ori obtained using VLTI/GRAVITY. Continuum K-band circum-primary and circum-secondary emission are marginally spatially resolved for the first time, while Brγ emission is detected in the spectrum of the secondary. We estimate a spectral type range for CO Ori B of K2-K5 assuming visual extinction, AV = 2 and a distance of 430 pc. From geometric modelling of the continuum visibilities, the circum-primary emission is consistent with a central point source plus a Gaussian component with a full width at half-maximum of 2.31 ± 0.04 mas, inclined at 30.2° ± 2.2° and with a major axis position angle of 40° ± 6°. This inclination is lower than that reported for the discs of other UX Ori-type stars, providing a first indication that the UX Ori phenomena may arise through fluctuations in circum-stellar material exterior to a disc, for example, in a dusty outflow. An additional wide, symmetric Gaussian component is required to fit the visibilities of CO Ori B, signifying a contribution from scattered light. Finally, closure phases of CO Ori A were used to investigate whether the 12.4 yr periodicity is associated with an undetected third component, as has been previously suggested. We rule out any additional companions contributing more than 3.6 per cent to the K-band flux within ˜7.3-20 mas of CO Ori A.

The luminous blue variable HR Carinae has a partner. Discovery of a companion with the VLTI

NASA Astrophysics Data System (ADS)

Boffin, Henri M. J.; Rivinius, Thomas; Mérand, Antoine; Mehner, Andrea; LeBouquin, Jean-Baptiste; Pourbaix, Dimitri; de Wit, Willem-Jan; Martayan, Christophe; Guieu, Sylvain

2016-09-01

Luminous blue variables (LBVs) are massive stars caught in a post-main sequence phase, during which they lose a significant amount of mass. Since, on one hand, it is thought that the majority of massive stars are close binaries that will interact during their lifetime, and on the other, the most dramatic example of an LBV, η Car, is a binary, it would be useful to find other binary LBVs. We present here interferometric observations of the LBV HR Car done with the AMBER and PIONIER instruments attached to ESO's Very Large Telescope Interferometer (VLTI). Our observations, spanning two years, clearly reveal that HR Car is a binary star. It is not yet possible to fully constrain the orbit, and the orbital period may lie between a few years and several hundred years. We derive a radius for the primary in the system and possibly also resolve the companion. The luminosity ratio in the H-band between the two components is changing with time, going from about 6 to 9. We also tentatively detect the presence of some background flux which remained at the 2% level until January 2016, but then increased to 6% in April 2016. Our AMBER results show that the emission line-forming region of Brγ is more extended than the continuum-emitting region as seen by PIONIER and may indicate some wind-wind interaction. Most importantly, we constrain the total masses of both components, with the most likely range being 33.6 M⊙ and 45 M⊙. Our results show that the LBV HR Car is possibly an η Car analog binary system with smaller masses, with variable components, and further monitoring of this object is definitively called for. Based on data obtained with ESO programmes 092.C-0243, 092.D-0289, 092.D-0296, 094.D-0069, and 596.D-0335.

OzDES multifibre spectroscopy for the Dark Energy Survey: Three year results and first data release

DOE PAGES

Childress, M. J.; Lidman, C.; Davis, T. M.; ...

2017-07-26

We present results for the first three years of OzDES, a six-year programme to obtain redshifts for objects in the Dark Energy Survey (DES) supernova fields using the 2dF fibre positioner and AAOmega spectrograph on the Anglo-Australian Telescope. OzDES is a multi-object spectroscopic survey targeting multiple types of targets at multiple epochs over a multi-year baseline, and is one of the first multi-object spectroscopic surveys to dynamically include transients into the target list soon after their discovery. At the end of three years, OzDES has spectroscopically confirmed almost 100 supernovae, and has measured redshifts for 17,000 objects, including the redshiftsmore » of 2,566 supernova hosts. We examine how our ability to measure redshifts for targets of various types depends on signal-to-noise, magnitude, and exposure time, finding that our redshift success rate increases significantly at a signal-to-noise of 2 to 3 per 1-Angstrom bin. We also find that the change in signal-to-noise with exposure time closely matches the Poisson limit for stacked exposures as long as 10 hours. We use these results to predict the redshift yield of the full OzDES survey, as well as the potential yields of future surveys on other facilities such as the 4m Multi-Object Spectroscopic Telescope (4MOST), the Subaru Prime Focus Spectrograph (PFS), and the Maunakea Spectroscopic Explorer (MSE). This work marks the first OzDES data release, comprising 14,693 redshifts. OzDES is on target to obtain over a yield of approximately 5,700 supernova host-galaxy redshifts.« less

OzDES multifibre spectroscopy for the Dark Energy Survey: Three year results and first data release

DOE Office of Scientific and Technical Information (OSTI.GOV)

Childress, M. J.; Lidman, C.; Davis, T. M.

We present results for the first three years of OzDES, a six-year programme to obtain redshifts for objects in the Dark Energy Survey (DES) supernova fields using the 2dF fibre positioner and AAOmega spectrograph on the Anglo-Australian Telescope. OzDES is a multi-object spectroscopic survey targeting multiple types of targets at multiple epochs over a multi-year baseline, and is one of the first multi-object spectroscopic surveys to dynamically include transients into the target list soon after their discovery. At the end of three years, OzDES has spectroscopically confirmed almost 100 supernovae, and has measured redshifts for 17,000 objects, including the redshiftsmore » of 2,566 supernova hosts. We examine how our ability to measure redshifts for targets of various types depends on signal-to-noise, magnitude, and exposure time, finding that our redshift success rate increases significantly at a signal-to-noise of 2 to 3 per 1-Angstrom bin. We also find that the change in signal-to-noise with exposure time closely matches the Poisson limit for stacked exposures as long as 10 hours. We use these results to predict the redshift yield of the full OzDES survey, as well as the potential yields of future surveys on other facilities such as the 4m Multi-Object Spectroscopic Telescope (4MOST), the Subaru Prime Focus Spectrograph (PFS), and the Maunakea Spectroscopic Explorer (MSE). This work marks the first OzDES data release, comprising 14,693 redshifts. OzDES is on target to obtain over a yield of approximately 5,700 supernova host-galaxy redshifts.« less

Fundamental properties and atmospheric structure of the red supergiant VY Canis Majoris based on VLTI/AMBER spectro-interferometry

NASA Astrophysics Data System (ADS)

Wittkowski, M.; Hauschildt, P. H.; Arroyo-Torres, B.; Marcaide, J. M.

2012-04-01

Aims: We investigate the atmospheric structure and fundamental properties of the red supergiant VY CMa. Methods: We obtained near-infrared spectro-interferometric observations of VY CMa with spectral resolutions of 35 and 1500 using the AMBER instrument at the VLTI. Results: The visibility data indicate the presence of molecular layers of water vapor and CO in the extended atmosphere with an asymmetric morphology. The uniform disk diameter in the water band around 2.0 μm is increased by ~20% compared to the near-continuum bandpass at 2.20-2.25 μm, and in the CO band at 2.3-2.5 μm it is increased by up to ~50%. The closure phases indicate relatively small deviations from point symmetry close to the photospheric layer, and stronger deviations in the extended H2O and CO layers. Making use of the high spatial and spectral resolution, a near-continuum bandpass can be isolated from contamination by molecular and dusty layers, and the Rosseland-mean photospheric angular diameter is estimated to 11.3 ± 0.3 mas based on a PHOENIX atmosphere model. Together with recent high-precision estimates of the distance and spectro-photometry, this estimate corresponds to a radius of 1420 ± 120 R⊙ and an effective temperature of 3490 ± 90 K. Conclusions: VY CMa exhibits asymmetric, possibly clumpy, atmospheric layers of H2O and CO, which are not co-spatial, within a larger elongated dusty envelope. Our revised fundamental parameters put VY CMa close to the Hayashi limit of recent evolutionary tracks of initial mass 25 M⊙ with rotation or 32 M⊙ without rotation, shortly before evolving blueward in the HR-diagram. Based on observations made with the VLT Interferometer (VLTI) at Paranal Observatory under programme ID 386.D-0012.Figures 2, 3 and 5 are available in electronic form at http://www.aanda.org

Eta Carinae: What We have learned recently with HST/STIS, VLT/UVES and VLTI: What We Might Learn with VLT/VLTI across the 2008/9 Minimum

NASA Technical Reports Server (NTRS)

Gull, Theodore R.

2005-01-01

Eta Carinae, the LBV that we have learned to love and hate, has revealed many clues of its character over the past seven years by studies with HST and VLT. Based upon X-Ray, optical and IR observations, Eta Carinae is convincingly a massive binary system that uniquely has major nebular ejecta that are connected with historical outbursts. We have successhlly followed the stellar and nebular changes over the 5.5 year cycle, especially with STIS and RXTE, and across the spectroscopic minimum in 2003.5 with STIS, CHANDRA, RXTE, FUSE, and VLT/UVES. The HST/STIS high spatial resolution, combined with appropriate spectral resolving powers from 1150 to 10300 A, has revealed much about the Central Source and especially the spatially resolved extended stellar atmosphere and the ejecta, known as the Homunculus. Indeed the neutral, dusty outer Homunculus, ejected in the 1840s, envelops the newly discovered ionized Little Homunculus, ejected in the 1890s. In line of sight, multiple hot clumps, both ionized and neutral, are seen in absorption and provide much information on the physical conditions of these massive ejecta. Against the nebular-scattered starlight, wind and nebular absorptions provide views at different angles from line of sight. The VLT/UVES studies from 2002 through 2004 provided very important time-sampled spectra of both the star as seen directly and as seen by the SE lobe viewing the polar region of the star. The VLTI 2.2 micron measures of the central source are consistent with a prolate spheroid with its axis extending along the axis of the Homunculus. This is consistent with the noticeably larger wind mass and higher terminal velocity along the axis of the Homunculus compared to that measured in line of sight at about 45 degrees from the polar axes. We understand the system to be a massive primary with an O or WR companion in a very highly elliptical orbit. The spectroscopic minimum occurs during periastron, when the greatly extended primary atmosphere and wind bottles up the ionizing uv radiation of the companion star. This transient drop in uv photons leads to recombination of much of the wind structure and of the nearby ejecta. Doubly-ionized elements (iron, neon, argon, vanadium) recombine to singly ionized forms and extended structures on the scales of below 0.03 arcseconds to an arcsecond change, appear, or disappear. With the loss of the STIS on HST, ground-based observations, especially with high spatial-resolution facilities, including the VLT and VLTI will be key to further studies across the minimum centered on 2009.0. Now is the time to plan for these studies.

Witnessing Atmospheric Motions in Cool Evolved Stars with VLTI/Amber

NASA Astrophysics Data System (ADS)

Ohnaka, Keiichi

2018-04-01

Studies of the mass loss from stars in late evolutionary stages are of utmost importance for improving our understanding of not only stellar evolution but also the chemical enrichment of galaxies. Despite such importance, the mass loss from cool evolved stars is one of the long-standing problems in stellar astrophysics. Milliarcsecond resolution achieved by optical/infrared long-baseline interferometry provides a unique opportunity to spatially resolve this innermost key region. We have recently succeeded not only in imaging the surface of the red supergiant Antares in the 2.3 micron CO lines in unprecedented detail but also in witnessing, for the first time, the complex gas dynamics over the surface and atmosphere of the star. Our 2-D velocity field map of Antares reveals vigorous upwelling and downdrafting motions of large gas clumps in the atmosphere extending out to 1.7 stellar radii. This suggests that the mass loss in red supergiants may be launched in a turbulent, clumpy manner. We will also present preliminary results of the velocity-resolved imaging of an AGB star. Our work opens an entirely new window to observe stars just like in observations of the Sun.

New Light on Dark Energy

NASA Astrophysics Data System (ADS)

2008-01-01

Using ESO's Very Large Telescope Interferometer, astronomers have probed the inner parts of the disc of material surrounding a young stellar object, witnessing how it gains its mass before becoming an adult. ESO PR Photo 03/08 ESO PR Photo 03a/08 The disc around MWC 147 (Artist's Impression) The astronomers had a close look at the object known as MWC 147, lying about 2,600 light years away towards the constellation of Monoceros ('the Unicorn'). MWC 147 belongs to the family of Herbig Ae/Be objects. These have a few times the mass of our Sun and are still forming, increasing in mass by swallowing material present in a surrounding disc. MWC 147 is less than half a million years old. If one associated the middle-aged, 4.6 billion year old Sun with a person in his early forties, MWC 147 would be a 1-day-old baby [1]. The morphology of the inner environment of these young stars is however a matter of debate and knowledge of it is important to better understand how stars and their cortège of planets form. The astronomers Stefan Kraus, Thomas Preibisch, and Keiichi Ohnaka have used the four 8.2-m Unit Telescopes of ESO's Very Large Telescope to this purpose, combining the light from two or three telescopes with the MIDI and AMBER instruments. "With our VLTI/MIDI and VLTI/AMBER observations of MWC147, we combine, for the first time, near- and mid-infrared interferometric observations of a Herbig Ae/Be star, providing a measurement of the disc size over a wide wavelength range [2]," said Stefan Kraus, lead-author of the paper reporting the results. "Different wavelength regimes trace different temperatures, allowing us to probe the disc's geometry on the smaller scale, but also to constrain how the temperature changes with the distance from the star." The near-infrared observations probe hot material with temperatures of up to a few thousand degrees in the innermost disc regions, while the mid-infrared observations trace cooler dust further out in the disc. The observations show that the temperature changes with radius are much steeper than predicted by the currently favoured models, indicating that most of the near-infrared emission emerges from hot material located very close to the star, that is, within one or two times the Earth-Sun distance (1-2 AU). This also implies that dust cannot exist so close to the star, since the strong energy radiated by the star heats and ultimately destroys the dust grains. ESO PR Photo 03/08 ESO PR Photo 03b/08 The Region Around MWC 147 "We have performed detailed numerical simulations to understand these observations and reached the conclusion that we observe not only the outer dust disc, but also measure strong emission from a hot inner gaseous disc. This suggests that the disc is not a passive one, simply reprocessing the light from the star," explained Kraus. "Instead, the disc is active, and we see the material, which is just transported from the outer disc parts towards the forming star." ESO PR Photo 03/08 ESO PR Photo 03c/08 Close-up on MWC 147 The best-fit model is that of a disc extending out to 100 AU, with the star increasing in mass at a rate of seven millionths of a solar mass per year. "Our study demonstrates the power of ESO's VLTI to probe the inner structure of discs around young stars and to reveal how stars reach their final mass," said Stefan Kraus. More Information The authors report their results in a paper in the Astrophysical Journal ("Detection of an inner gaseous component in a Herbig Be star accretion disk: Near- and mid-infrared spectro-interferometry and radiative transfer modeling of MWC 147", by Stefan Kraus, Thomas Preibisch, Keichii Ohnaka").

The Growing-up of a Star

NASA Astrophysics Data System (ADS)

2008-01-01

Using ESO's Very Large Telescope Interferometer, astronomers have probed the inner parts of the disc of material surrounding a young stellar object, witnessing how it gains its mass before becoming an adult. ESO PR Photo 03/08 ESO PR Photo 03a/08 The disc around MWC 147 (Artist's Impression) The astronomers had a close look at the object known as MWC 147, lying about 2,600 light years away towards the constellation of Monoceros ('the Unicorn'). MWC 147 belongs to the family of Herbig Ae/Be objects. These have a few times the mass of our Sun and are still forming, increasing in mass by swallowing material present in a surrounding disc. MWC 147 is less than half a million years old. If one associated the middle-aged, 4.6 billion year old Sun with a person in his early forties, MWC 147 would be a 1-day-old baby [1]. The morphology of the inner environment of these young stars is however a matter of debate and knowledge of it is important to better understand how stars and their cortège of planets form. The astronomers Stefan Kraus, Thomas Preibisch, and Keiichi Ohnaka have used the four 8.2-m Unit Telescopes of ESO's Very Large Telescope to this purpose, combining the light from two or three telescopes with the MIDI and AMBER instruments. "With our VLTI/MIDI and VLTI/AMBER observations of MWC147, we combine, for the first time, near- and mid-infrared interferometric observations of a Herbig Ae/Be star, providing a measurement of the disc size over a wide wavelength range [2]," said Stefan Kraus, lead-author of the paper reporting the results. "Different wavelength regimes trace different temperatures, allowing us to probe the disc's geometry on the smaller scale, but also to constrain how the temperature changes with the distance from the star." The near-infrared observations probe hot material with temperatures of up to a few thousand degrees in the innermost disc regions, while the mid-infrared observations trace cooler dust further out in the disc. The observations show that the temperature changes with radius are much steeper than predicted by the currently favoured models, indicating that most of the near-infrared emission emerges from hot material located very close to the star, that is, within one or two times the Earth-Sun distance (1-2 AU). This also implies that dust cannot exist so close to the star, since the strong energy radiated by the star heats and ultimately destroys the dust grains. ESO PR Photo 03/08 ESO PR Photo 03b/08 The Region Around MWC 147 "We have performed detailed numerical simulations to understand these observations and reached the conclusion that we observe not only the outer dust disc, but also measure strong emission from a hot inner gaseous disc. This suggests that the disc is not a passive one, simply reprocessing the light from the star," explained Kraus. "Instead, the disc is active, and we see the material, which is just transported from the outer disc parts towards the forming star." ESO PR Photo 03/08 ESO PR Photo 03c/08 Close-up on MWC 147 The best-fit model is that of a disc extending out to 100 AU, with the star increasing in mass at a rate of seven millionths of a solar mass per year. "Our study demonstrates the power of ESO's VLTI to probe the inner structure of discs around young stars and to reveal how stars reach their final mass," said Stefan Kraus. More Information The authors report their results in a paper in the Astrophysical Journal ("Detection of an inner gaseous component in a Herbig Be star accretion disk: Near- and mid-infrared spectro-interferometry and radiative transfer modeling of MWC 147", by Stefan Kraus, Thomas Preibisch, Keichii Ohnaka").

Sustaining Software-Intensive Systems

DTIC Science & Technology

2006-05-01

2.2 Multi- Service Operational Test and Evaluation .......................................4 2.3 Stable Software Baseline...or equivalent document • completed Multi- Service Operational Test and Evaluation (MOT&E) for the potential production software package (or OT&E if...not multi- service ) • stable software production baseline • complete and current software documentation • Authority to Operate (ATO) for an

A Pareto-based Ensemble with Feature and Instance Selection for Learning from Multi-Class Imbalanced Datasets.

PubMed

Fernández, Alberto; Carmona, Cristobal José; José Del Jesus, María; Herrera, Francisco

2017-09-01

Imbalanced classification is related to those problems that have an uneven distribution among classes. In addition to the former, when instances are located into the overlapped areas, the correct modeling of the problem becomes harder. Current solutions for both issues are often focused on the binary case study, as multi-class datasets require an additional effort to be addressed. In this research, we overcome these problems by carrying out a combination between feature and instance selections. Feature selection will allow simplifying the overlapping areas easing the generation of rules to distinguish among the classes. Selection of instances from all classes will address the imbalance itself by finding the most appropriate class distribution for the learning task, as well as possibly removing noise and difficult borderline examples. For the sake of obtaining an optimal joint set of features and instances, we embedded the searching for both parameters in a Multi-Objective Evolutionary Algorithm, using the C4.5 decision tree as baseline classifier in this wrapper approach. The multi-objective scheme allows taking a double advantage: the search space becomes broader, and we may provide a set of different solutions in order to build an ensemble of classifiers. This proposal has been contrasted versus several state-of-the-art solutions on imbalanced classification showing excellent results in both binary and multi-class problems.

Imaging of Prominent Carbon Stars: From CRIRES and NACO to MATISSE

NASA Astrophysics Data System (ADS)

Hron, Josef

2018-04-01

We present an update to the spectro-astrometry carried out with CRIRES for some prominent carbon stars in the L- and M-bands. For TX Psc additional NACO imaging is compared with the CRIRES results. We also discuss the prospects and plans for MATISSE, the second generation VLTI instrument to operate in L, M and N.

Tracing the young massive high-eccentricity binary system θ^1Orionis C through periastron passage

NASA Astrophysics Data System (ADS)

Kraus, S.; Weigelt, G.; Balega, Y. Y.; Docobo, J. A.; Hofmann, K.-H.; Preibisch, T.; Schertl, D.; Tamazian, V. S.; Driebe, T.; Ohnaka, K.; Petrov, R.; Schöller, M.; Smith, M.

2009-04-01

Context: The nearby high-mass star binary system θ^1Ori C is the brightest and most massive of the Trapezium OB stars at the core of the Orion Nebula Cluster, and it represents a perfect laboratory to determine the fundamental parameters of young hot stars and to constrain the distance of the Orion Trapezium Cluster. Aims: By tracing the orbital motion of the θ^1Ori C components, we aim to refine the dynamical orbit of this important binary system. Methods: Between January 2007 and March 2008, we observed θ^1Ori C with VLTI/AMBER near-infrared (H- and K-band) long-baseline interferometry, as well as with bispectrum speckle interferometry with the ESO 3.6 m and the BTA 6 m telescopes (B'- and V'-band). Combining AMBER data taken with three different 3-telescope array configurations, we reconstructed the first VLTI/AMBER closure-phase aperture synthesis image, showing the θ^1Ori C system with a resolution of ˜ 2 mas. To extract the astrometric data from our spectrally dispersed AMBER data, we employed a new algorithm, which fits the wavelength-differential visibility and closure phase modulations along the H- and K-band and is insensitive to calibration errors induced, for instance, by changing atmospheric conditions. Results: Our new astrometric measurements show that the companion has nearly completed one orbital revolution since its discovery in 1997. The derived orbital elements imply a short-period (P ≈ 11.3 yr) and high-eccentricity orbit (e ≈ 0.6) with periastron passage around 2002.6. The new orbit is consistent with recently published radial velocity measurements, from which we can also derive the first direct constraints on the mass ratio of the binary components. We employ various methods to derive the system mass (M_system = 44 ± 7 M⊙) and the dynamical distance (d = 410 ± 20 pc), which is in remarkably good agreement with recently published trigonometric parallax measurements obtained with radio interferometry. Based on observations made with ESO telescopes at the La Silla Paranal Observatory under the OT and VISA-MPG GTO programme IDs 078.C-0360(A), 080.C-0541(A,B,C,D), 080.D-0225(B), and 080.C-0388(A).

A snapshot of the inner dusty regions of a R CrB-type variable

NASA Astrophysics Data System (ADS)

Leão, I. C.; de Laverny, P.; Chesneau, O.; Mékarnia, D.; de Medeiros, J. R.

2007-05-01

Context: R Coronae Borealis (R CrB) variable stars are suspected to sporadically eject optically thick dust clouds causing, when one of them lies on the line-of-sight, a huge brightness decline in visible light. Direct detections with 8-m class adaptive optics of such clouds located at about 0.2-0.3 arcsec from the center (~1000 stellar radii) were recently reported for RY Sgr, the brightest R CrB of the southern hemisphere. Aims: Mid-infrared interferometric observations of RY Sgr allowed us to explore the circumstellar regions much closer to the central star (~20-40 mas) to look for the signature of any heterogeneities and to characterize them. Methods: Using the VLTI/MIDI instrument, five dispersed visibility curves in the N-band were recorded in May and June 2005 with different projected baselines oriented towards two roughly perpendicular directions. The large spatial frequencies' visibility curves exhibit a sinusoidal shape, whereas, at shorter spatial frequencies' visibility curves follow a Gaussian decrease. These observations are well interpreted with a geometrical model consisting of a central star surrounded by an extended circumstellar envelope in which one bright cloud is embedded. Results: Within this simple geometrical scheme, the inner 110 AU dusty environment of RY Sgr is dominated at the time of observations by a single dusty cloud, which at 10 μm represents ~10% of the total flux of the whole system, slightly less that the star flux. The cloud is located at about 100 stellar radii (or ~30 AU) from the center toward the East-North-East direction (or the symmetric direction with respect to center) within a circumstellar envelope whose FWHM is about 120 stellar radii. This first detection of a cloud so close to the central star supports the classical scenario of the R CrB brightness variations in the optical spectral domain and demonstrates the feasibility of a temporal monitoring of the dusty environment of this star on a monthly scale. Based on observations collected with the VLTI/MIDI instrument at Paranal Observatory, ESO (Chile) - Programme 75.D-0660. FITS files for the visibilities are only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/466/L1

Robust optimization of supersonic ORC nozzle guide vanes

NASA Astrophysics Data System (ADS)

Bufi, Elio A.; Cinnella, Paola

2017-03-01

An efficient Robust Optimization (RO) strategy is developed for the design of 2D supersonic Organic Rankine Cycle turbine expanders. The dense gas effects are not-negligible for this application and they are taken into account describing the thermodynamics by means of the Peng-Robinson-Stryjek-Vera equation of state. The design methodology combines an Uncertainty Quantification (UQ) loop based on a Bayesian kriging model of the system response to the uncertain parameters, used to approximate statistics (mean and variance) of the uncertain system output, a CFD solver, and a multi-objective non-dominated sorting algorithm (NSGA), also based on a Kriging surrogate of the multi-objective fitness function, along with an adaptive infill strategy for surrogate enrichment at each generation of the NSGA. The objective functions are the average and variance of the isentropic efficiency. The blade shape is parametrized by means of a Free Form Deformation (FFD) approach. The robust optimal blades are compared to the baseline design (based on the Method of Characteristics) and to a blade obtained by means of a deterministic CFD-based optimization.

Towards a coherent view of mass loss in Betelgeuse from the photosphere to the interstellar medium

NASA Astrophysics Data System (ADS)

Montarges, Miguel; Kervella, Pierre; Perrin, Guy

2013-06-01

Massive evolved stars contribute to the chemical enrichment of the interstellar medium (ISM), the Galaxy and ultimately the Universe through their mass loss. From the photosphere to the ISM, large convective motions, low surface gravity and high brightness combine to trigger an intense stellar wind. The released material evolves chemically as the distance from the star increases, and eventually forms dust particles. The involved physical and chemical processes are central to apprehend the cosmic impact of massive evolved stars, but they are poorly understood: the surface convection remains essentially uncharacterized, as the composition of the wind, and the role of the magnetic field is unknown. Betelgeuse is the closest red supergiant and therefore it stands out as the best candidate to obtain detailed observations of the close circumstellar environment of a massive evolved star. We are currently running a high angular resolution observations program to obtain a multi-wavelength and multi-epoch characterisation of this star. Using the IOTA interferometer, Haubois et al. reconstructed an image of the photosphere of the star. Within 1 to 100 stellar radii, the VLT and VLTI allowed us to probe the compact molecular envelope of Betelgeuse (the MOLsphere) in the near-infrared, and the extended dusty envelope in the thermal infrared domain. They were recently completed with HST/STIS observations of the chromosphere in the UV, whose location is surprisingly coincident with the MOLsphere. We will present a brief review of our recent results and of our ongoing work on Betelgeuse.

Prognostic value of baseline absolute lymphocyte concentration and neutrophil/lymphocyte ratio in dogs with newly diagnosed multi-centric lymphoma.

PubMed

Mutz, M; Boudreaux, B; Kearney, M; Stroda, K; Gaunt, S; Shiomitsu, K

2015-12-01

Canine multi-centric B-cell lymphoma shares similarities with diffuse large B-cell (Non-Hodgkin's) lymphoma (NHL) in people. In people with NHL, lymphopenia at diagnosis and first relapse and neutrophil/lymphocyte ratio (N:L) > 3.5 are negative prognostic factors for survival. The objective of this study was to determine if lymphocyte concentration at diagnosis and first relapse and N:L were prognostic for survival in dogs with newly diagnosed multi-centric lymphoma. Medical records of 77 dogs with multi-centric lymphoma treated with a CHOP-based chemotherapy protocol were retrospectively evaluated. Absolute lymphocyte concentration and N:L ratio at presentation of dogs pre-treated with steroids was not significantly different from dogs who had not received steroids. On multivariate analysis, only immunophenotype remained significant for progression-free survival (PFS), whereas no variables remained significant for ST. A prospective study of these haematologic variables is warranted to assess their true significance. © 2013 John Wiley & Sons Ltd.

Many-objective reservoir policy identification and refinement to reduce institutional myopia in water management

NASA Astrophysics Data System (ADS)

Giuliani, Matteo; Herman, Jonathan D.; Castelletti, Andrea; Reed, Patrick M.

2014-05-01

Current water reservoir operating policies are facing growing water demands as well as increasing uncertainties associated with a changing climate. However, policy inertia and myopia strongly limit the possibility of adapting current water reservoir operations to the undergoing change. Historical agreements and regulatory constraints limit the rate that reservoir operations are innovated and creates policy inertia, where water institutions are unlikely to change their current practices in absence of dramatic failures. Yet, no guarantee exists that historical management policies will not fail in coming years. In reference to policy myopia, although it has long been recognized that water reservoir systems are generally framed in heterogeneous socio-economic contexts involving a myriad of conflicting, non-commensurable operating objectives, the broader understanding of the multi-objective consequences of current operating rules as well as their vulnerability to hydroclimatic uncertainties is severely limited. This study proposes a decision analytic framework to overcome both policy inertia and myopia in complex river basin management contexts. The framework combines reservoir policy identification, many-objective optimization under uncertainty, and visual analytics to characterize current operations and discover key tradeoffs between alternative policies for balancing evolving demands and system uncertainties. The approach is demonstrated on the Conowingo Dam, located within the Lower Susquehanna River, USA. The Lower Susquehanna River is an interstate water body that has been subject to intensive water management efforts due to the system's competing demands from urban water supply, atomic power plant cooling, hydropower production, and federally regulated environmental flows. The proposed framework initially uses available streamflow observations to implicitly identify the current but unknown operating policy of Conowingo Dam. The quality of the identified baseline policy was validated by its ability to replicate historical release dynamics. Starting from this baseline policy, we then combine evolutionary many-objective optimization with visual analytics to discover new operating policies that better balance the tradeoffs within the Lower Susquehanna. Results confirm that the baseline operating policy, which only considers deterministic historical inflows, significantly overestimates the reliability of the reservoir's competing demands. The proposed framework removes this bias by successfully identifying alternative reservoir policies that are more robust to hydroclimatic uncertainties, while also better addressing the tradeoffs across the Conowingo Dam's multi-sector services.

Imaging reconstruction for infrared interferometry: first images of YSOs environment

NASA Astrophysics Data System (ADS)

Renard, S.; Malbet, F.; Thiébaut, E.; Berger, J.-P.

2008-07-01

The study of protoplanetary disks, where the planets are believed to form, will certainly allow the formation of our Solar System to be understood. To conduct observations of these objects at the milli-arcsecond scale, infrared interferometry provides the right performances for T Tauri, FU Ori or Herbig Ae/Be stars. However, the only information obtained so far are scarce visibility measurements which are directly tested with models. With the outcome of recent interferometers, one can foresee obtaining images reconstructed independently of the models. In fact, several interferometers including IOTA and AMBER on the VLTI already provide the possibility to recombine three telescopes at once and thus to obtain the data necessary to reconstruct images. In this paper, we describe the use of MIRA, an image reconstruction algorithm developed for optical interferometry data (squared visibilities and closure phases) by E. Thiébaut. We foresee also to use the spectral information given by AMBER data to constrain even better the reconstructed images. We describe the use of MIRA to reconstruct images of young stellar objects out of actual data, in particular the multiple system GW Orionis (IOTA, 2004), and discuss the encountered difficulties.

Modeling of Red Giant and AGB Stars Atmospheres: Constraints from VLTI and HST Observations

NASA Astrophysics Data System (ADS)

Rau, Gioia

2018-04-01

The chemical enrichment of the Universe is considerably affected by the contributions of low-to-intermediate mass stars through the mass-loss provided via their stellar winds. First, we will present our investigation in the near-IR with VLTI/GRAVITY (Wittkowski, Rau, et al., in prep.). Our aim was to verify at different epochs the model-predicted variability of the visibility spectra. We use CODEX model atmospheres, as well as best-fit 3D radiation hydrodynamic simulations (e.g. Freytag et al., 2017), for comparison with the observations. Our preliminary results on R Peg suggest a decreasing contribution by extended CO layers as the star transitions from maximum to minimum phase. Second, we will show a preliminary modeling of UV spectra obtained with HST/GHRS that contain chromospheric emission lines of, e.g., Mg II and Fe II. Via Sobolev with Exact Integration (SEI) modeling, we determined for the two M-giant stars γ Cru and µ Gem the characteristics of their winds (turbulence, acceleration, and opacity), and their average global mass-loss rates (Rau, Carpenter et al., in prep.). Finally, we briefly discuss the impact of instruments on board JWST in progressing this investigation.

VLTI-Pionier Imaging of the Carbon AGB Star R Sculptoris and the Supergiant V766 Centauri

NASA Astrophysics Data System (ADS)

Wittkowski, Markus

2018-04-01

I will present reconstructed images of the carbon-rich AGB star R Scl and of the supergiant V766 Cen, both recently obtained from VLTI-PIONIER data. The images are compared to state-of-the art atmosphere and wind models. The images of R Scl exhibit a complex structure within the stellar disk. This structure is most likely caused by giant convection cells, resulting in large-scale shock fronts, and their effects on clumpy molecule and dust formation seen against the photosphere. Images of V 766 Cen were obtained at three epochs. The first epoch shows a complex elongated structure within the photospheric disk, consistent with a red supergiant harboring giant photospheric convection cells. The second and third epochs show a qualitatively and quantitatively different structure with significantly increased contrast, which is not compatible with current models of convection. Instead we interpret the 2016 and 2017 epochs as showing a previously suggested close eclipsing companion in front of the primary, which was located behind the primary at the 2014 epoch. Finally, I will show preliminary reconstructed images of a small sample of further red supergiants.

Implementation of EcoAIM (trademark) - A Multi-Objective Decision Support Tool for Ecosystem Services at Department of Defense Installations

DTIC Science & Technology

2014-09-26

neotropical birds , as well as its high-quality habitat for resident birds in the Chesapeake Bay watershed, such as bald eagles and several species of...Duelli and Obrist 2003). Several papers have developed methods that relate measurable habitat features at various spatial scales to species richness ...advised to first establish a baseline in which a species adheres to patterns of ideal habitat selection (Johnson 2007). In the case of the APG bird

Multi-epoch VLTI-PIONIER imaging of the supergiant V766 Cen

NASA Astrophysics Data System (ADS)

Wittkowski, M.; Abellán, F. J.; Arroyo-Torres, B.; Chiavassa, A.; Guirado, J. C.; Marcaide, J. M.; Alberdi, A.; de Wit, W. J.; Hofmann, K.-H.; Meilland, A.; Millour, F.; Mohamed, S.; Sanchez-Bermudez, J.

2017-09-01

Context. The star V766 Cen (=HR 5171A) was originally classified as a yellow hypergiant but lately found to more likely be a 27-36 M⊙ red supergiant (RSG). Recent observations indicated a close eclipsing companion in the contact or common-envelope phase. Aims: Here, we aim at imaging observations of V766 Cen to confirm the presence of the close companion. Methods: We used near-infrared H-band aperture synthesis imaging at three epochs in 2014, 2016, and 2017, employing the PIONIER instrument at the Very Large Telescope Interferometer (VLTI). Results: The visibility data indicate a mean Rosseland angular diameter of 4.1 ± 0.8 mas, corresponding to a radius of 1575 ± 400 R⊙. The data show an extended shell (MOLsphere) of about 2.5 times the Rosseland diameter, which contributes about 30% of the H-band flux. The reconstructed images at the 2014 epoch show a complex elongated structure within the photospheric disk with a contrast of about 10%. The second and third epochs show qualitatively and quantitatively different structures with a single very bright and narrow feature and high contrasts of 20-30%. This feature is located toward the south-western limb of the photospheric stellar disk. We estimate an angular size of the feature of 1.7 ± 0.3 mas, corresponding to a radius of 650 ± 150 R⊙, and giving a radius ratio of 0.42+0.35-0.10 compared to the primary stellar disk. Conclusions: We interpret the images at the 2016 and 2017 epochs as showing the close companion, or a common envelope toward the companion, in front of the primary. At the 2014 epoch, the close companion is behind the primary and not visible. Instead, the structure and contrast at the 2014 epoch are typical of a single RSG harboring giant photospheric convection cells. The companion is most likely a cool giant or supergiant star with a mass of 5+15-3 M⊙. Based on observations made with the VLT Interferometer at Paranal Observatory under programme IDs 092.D-0096, 092.C-0312, and 097.D-0286.Olivier Chesneau was PI of the program 092.D-0096. He unfortunately passed away before seeing the results coming out of it. This Letter may serve as a posthumous tribute to his inspiring work on this source.

Astrophysical phenomena related to supermassive black holes

NASA Astrophysics Data System (ADS)

Pott, Jörg-Uwe

2006-12-01

The thesis contains the results of my recent projects in astrophysical research. All projects aim at pushing the limits of our knowledge about the interaction between a galaxy, the fundamental building block of today's universe, and a supermassive black hole (SMBH) at its center. Over the past years a lot of observational evidence has been gathered for the current understanding, that at least a major part of the galaxies with a stellar bulge contain central SMBHs. The typical extragalactic approach consists of searching for the spectroscopic pattern of Keplerian rotation, produced by stars and gas, when orbiting a central dark mass (Kormendy & Richstone 1995). It suggests that a significant fraction of large galaxies host in their very nucleus a SMBH of millions to billions of solar masses (Kormendy & Gebhardt 2001). In the closest case, the center of our Milky Way, the most central stars, which can be imaged, were shown to move on orbits with circulation times of a few decades only, evidencing a mass and compactness of the dark counter part of the Keplerian motion, which can only be explained by a SMBH (Eckart & Genzel 1996; Ghez et al. 2000; Schödel et al. 2002). Having acknowledged the widespread existence of SMBHs the obvious next step is investigating the interaction with their environment. Although the basic property of a SMBH, which is concentrating a huge amount of mass in a ludicrously small volume defined by the Schwarzschild radius, only creates a deep gravitational trough, its existence evokes much more phenomena than simply attracting the surrounding matter. It can trigger or exacerbate star formation via tidal forces (Morris 1993). It shapes the distribution of its surrounding matter to accretion discs, which themselves release gravitational potential energy as radiation, possibly due to magnetic friction (Blandford 1995). The radiation efficiency of such active galactic nuclei (AGN) can become roughly 100 times more efficient than atomic nuclear reactions in stars. In the most active galaxies known, the radiating accretion disc of the central SMBH engine easily outshines the stellar light of the entire galaxy (Blandford 1995). In addition to the light, plasma streams can emerge from the innermost regions at relativistic velocities, returning energy to the host galaxy (host) and creating jets and lobes with strong observational signatures, especially at radio and X-ray wavelengths (Wilson 2003). New insights in the wide field of SMBH/host interaction are often related to the development of new, more sensitive instruments and telescopes. For example the idea, that a high luminosity AGN may result from a merger event between two galaxies, could only develop with the upcoming high resolution and sensitive imaging capabilities needed to detect the highly distorted host galaxy morphologies of (post-)merger galaxies (Heckman et al. 1986). Furthermore multi-wavelength approaches, which combine the results of measurements at different wavelengths, often lead to new conclusions or confirm unsecured hypotheses. Thus developing a new instrument can be as valuable as combining different datasets. I follow both approaches and developed projects which (i) deal with new instrumentation and telescope technology, (ii) combine datasets from different wavelengths and resolutions, and (iii) incorporate recent theoretical models and predictions, which can be verified empirically. While some projects are more focused on investigating the power of new observational techniques, others incorporate acknowledged instruments to probe predictions based on previous observations and models and trace special phenomena of SMBH/host interaction. But in most cases aspects of all three items appear. The SMBH/host interaction results in phenomena at all linear size scales of the system, from the direct accretion of matter onto the central black hole up to radio jets crossing the entire galaxy. Thus interaction effects do not simply concentrate on the innermost region of a galaxy. Furthermore an increasing number of apparently totally distinct phenomena and properties of the SMBH/host system appear to be related to each other, provoking unifying ideas and models to explain the galaxy formation and evolution. For example several different types of AGN are understood as projection or orientation effects, claiming that the same AGN looks totally different as viewed from different sides (e.g. Antonucci & Miller 1985). The thesis is structured to reflect this general perception. All scales of size, AGN luminosity, and nuclear activity appear. The thesis consists of six chapters. The first two compile astrophysical and technical background of the individual projects, which themselves are presented in the following four chapters. While the first project (Chapter 3) deals with observations of the innermost parsec of our Galaxy, Chapter 4 presents data of the inner kpc of an active galaxy. The subjects of Chapters 5 and 6 are very luminous AGN/host systems, so-called QSOs. Whereas Chapter 5 presents global, spatially unresolved properties of SMBH/host systems, the radio jet, analyzed in the final Chapter 6, combines all size scales. It is investigated from close to its origin out to several kpc. The accretion onto the black hole of the Milky Way (Chapter 3) is extremely inefficient (Genzel et al. 2003a) and the SMBH possibly interacts dominantly via tidal forces only. The next discussed system (Chapter 4) is the prototype of moderately luminous Seyfert 2 AGN, NGC 1068. Here a strong local influence of the nuclear X-ray radiation is observed (Usero et al. 2004). Chapter 5 deals with the possible global importance of radiative interaction between highly luminous QSO AGN and the host. The radio jet in Chapter 6 definitely shows signs of interaction with the matter of its host several kpc away from the nucleus. Chapters 3-6 include a dedicated introductory and a conclusive section, which put the results obtained in the larger astrophysical context of the observation. The observational techniques chosen vary in dependence of the observed phenomenon. One major goal of especially Chapters 3 and 4 is to prove by successful explorative observations the scientific perspectives of the new instruments. Chapter 3 deals with the pioneering interferometric infrared study of stellar sources and their surroundings in the immediate vicinity of the SMBH at the center of the Milky Way. I was able to use the resolving power of an optical large baseline interferometer (OLBI) to investigate for the first time the different structures and excitation conditions of interstellar and circumstellar dust in 200 mpc distance to the SMBH. It is unknown whether the standard models for star and dust formation, which themselves dominate the infrared appearance of an inactive galaxy as the Milky Way, still apply under the strong tidal forces of gravity, exerted by the central SMBH. During the course of my doctoral research, I worked 2.5 years within the VLT Interferometry (VLTI) group of the European Southern Observatory (ESO) in M"unchen and Chile. I obtained the very first infrared fringes on GC sources and investigated the different instrument capabilities at the current sensitivity limit of the VLTI. The VLTI is the world leading stellar interferometric facility providing the infrastructure to combine the light of up to four 8m-class Adaptive Optics corrected telescopes, which themselves represent the state-of-the-art of optical-infrared telescope technology. The accomplished work includes the investigation of different data reduction techniques with respect to maximum accuracy and signal-to-noise ratios. The VLTI is right in the process of construction. While first modes are already open to the astronomical community, several advanced modes and instruments are still at different preliminary stages, ranging from early design studies to advanced instrument commissioning. The experiences of my VLTI observations, fully exploiting the currently available observing modes, and the data reduction were fed back via close collaboration to the Paranal Observatory and to the European science institutes of the instrument developing consortia1 . I contributed to improve the observing process (in particular to the infrared-based target acquisition of the instrument, and to the clarification of the chopping parameters) and the standard data reduction package (wavelength calibration, software debugging). The most recent NIR three-baseline observations of the GCIRS 7 helped to uncover imperfections in the numerical delay line model, which is needed to track the fringes during the observations. The smaller coherence lengths of these wide band observations were an ideal case to optimize the detector integration times for reaching highest signal-to-noise-ratios (SNR). The VLTI observations, described in Chapter 3, are the first observations of stellar interferometry in the infrared, which target objects through the 25 magnitudes of optical extinction along the line of sight toward the GC. One motivation for these observations, in addition to the direct scientific intention, was to create a showcase for advanced optical interferometry applications at the GC. An important part of the thesis is the detailed analysis of the achievable accuracy of the interferometric measurements. Such a precision study under the challenging conditions of off-axis optical AO guiding and faint target brightnesses close to the system limits has not been published before. Most of the interferometric observations were executed in the mid-infrared (MIR) wavelength regime at 10 μm (N -band), a natural starting point, because the optical requirements to the accuracy of the VLTI infrastructure are lower at these longer infrared wavelengths. The observed GCIRS 3 is an outstanding source at 10 μm being the most compact, brightest and isolated source at the GC. It bears significat signs of dust formation and will play a major role in understanding the dust formation and chemical properties of the local interstellar dust in the central parsec. The interferometric data of two observing seasons were interpreted together with different single telescope datasets. GCIRS 3 is known to be a very red luminous source, but no stellar spectrum could give away more detailed properties of the underlying source. I use a one-dimensional radiative transfer model to investigate the resolved dust shell properties, as observed with the 20 mas resolution of the VLTI at 10 μm. For the first time I can present results that show that the direct zone of dust formation around the deeply embedded star is observable. The temperature, derived from the spectral properties, and the spatial size, as derived from the high resolution interferometric dataset, show the cool star nature of the object. Earlier spatially unresolved N -band spectroscopic observations found a significant increase of oxygen rich silicate absorption towards GCIRS 3, deeper than towards the neighboring stars. The spectral properties of the VLTI data show that the immediate dust shell, formed by IRS 3 is not responsible for this strong absorption and might be devoid of a significant amount of silicate, favoring GCIRS 3 being a cool supergiant of ˜ 3000 K stellar temperature, forming more carbon-rich dust. The main impact of this result on GC science is, that the silicate-poor dust formation of GCIRS 3 and its silicate-rich surroundings appear to be the best place to study the extraordinary enrichment of the GC dust with interstellar amorphous silicate molecules (Roche & Aitken 1985). The dust formation in the nucleus of a galaxy is important, since only a detailed understanding of its composition helps to interpret the observed spectra and spectral energy distribution of spatially unresolved dusty nuclei of other galaxies. Furthermore the confirmed existence of a second massive red supergiant so close to GCIRS 7, which is already known to be a red supergiant, challenges the theories of star formation in galactic nuclei. Further currently possible VLTI-GC observations are presented in the following sections of Chapter 3. The dimensions of stellar bow-shocks are analyzed for the first time in the MIR to add information to the understanding of the kinematic features, which arise if massive stars with strong stellar winds ram into dense interstellar material. Such shock fronts can excite molecular hydrogen and add to the understanding of the excitation mechanisms in galactic nuclei (Pineau des Forêts et al. 2001). I show that such stellar bow-shocks are observable with the VLTI, and derive lower limits for their extension. Another set of first GC fringes was achieved in the near-infrared (NIR) at 2 μm on GCIRS 7. In one section of this chapter I describe the special importance of this star for future interferometric phase-referencing experiments. Despite of the technical problems occurred, fringes were found on one of the observed baseline, proving the feasibility of a detailed interferometric study of this putative phase calibrator in the near future. Phase referencing will significantly increase the number of observable targets, as soon as the respective hardware will be implemented. The following Chapter 4 reports on the first extragalactic sub-mm spectra of the innermost region in the Seyfert 2 prototype NGC 1068 with the new APEX telescope facility. The emission of the molecular rotational excitation lines CO(J=3-2) and HCN(J=4-3) were observed during the instrument testing phase. While the observations served for debugging the telescope operation, I prove that with dedicated data reduction already the current limited receiver capabilities are sufficient to measure broad extragalactic molecular line transitions in the sub-mm atmospheric transmission window. The observed lines are indispensable tracers of the warm and dense molecular gas (Papadopoulos & Seaquist 1999). The molecular gas is the major reservoir of matter in a galaxy, which supplies star formation and mass accretion onto the central SMBH. In Chapter 5, I present the results of the search for rotational line transitions at 80 GHz, in particular the 1-0 transition of the HCN molecule. It traces gas densities larger than 10e4/cm3 and is therefore a better quantitative tracers of the regions where star formation actually occurs than the stronger CO(1-0) transition, which correlates to the total amount of molecular gas which could be transformed into stars (Gao & Solomon 2004). The observed galaxies host a luminous quasar in their core. In nearby low luminosity AGN a relatively enhanced excitation of the HCN transition close to the central engine is observed (Usero et al. 2004). I investigate the hypothesis of an amplification and extension of this effect in high luminosity AGN from local nuclear to global galactic scales. Moreover the infrared luminosity ratios is used to trace global AGN dominance efficiently Then the detectability of enhanced HCN intensities due to intense nuclear X-ray irradiation and ionization is investigated. The measured upper limits are consistent with both normal and relatively enhanced HCN excitation. Quantitatively my results show that the detection of the expected HCN intensities in a statistically valuable sample of quasar host galaxies is within reach. In the last chapter, I analyze the physical properties of the radio jet in the radio loud quasar J1101+7225, which shows exceptionally far away from its nuclear origin (4 kpc) high relativistic motions. After a reanalysis of the cm-VLBI data, presented by Pott (2003), I include higher frequency data to follow the jet down to the hundred pc scale. The full analysis of the radio properties reveals an exemplary radio jet, which shows a complex inner structure including a possibly helical morphology. Far outside the nuclear region the jet rams into the host galaxy, which leads to a bending of the direction of propagation. Consequences for the galactic evolution of such interaction between the innermost accretion phenomenon and the surrounding host galaxy, which is typical for radio loud quasars, are not known yet. The diversity of the observations and results obtained gives an impression of the wide range of possible interactions between supermassive black holes and their host galaxies as well as of the many ways to observe them. Most of the presented results are published in peer-reviewed journals and presented at several conferences.

Multi-baseline bootstrapping at the Navy precision optical interferometer

NASA Astrophysics Data System (ADS)

Armstrong, J. T.; Schmitt, H. R.; Mozurkewich, D.; Jorgensen, A. M.; Muterspaugh, M. W.; Baines, E. K.; Benson, J. A.; Zavala, Robert T.; Hutter, D. J.

2014-07-01

The Navy Precision Optical Interferometer (NPOI) was designed from the beginning to support baseline boot- strapping with equally-spaced array elements. The motivation was the desire to image the surfaces of resolved stars with the maximum resolution possible with a six-element array. Bootstrapping two baselines together to track fringes on a third baseline has been used at the NPOI for many years, but the capabilities of the fringe tracking software did not permit us to bootstrap three or more baselines together. Recently, both a new backend (VISION; Tennessee State Univ.) and new hardware and firmware (AZ Embedded Systems and New Mexico Tech, respectively) for the current hybrid backend have made multi-baseline bootstrapping possible.

Safety and performance of the second generation EnligHTN™ Renal Denervation System in patients with drug-resistant, uncontrolled hypertension.

PubMed

Worthley, Stephen G; Wilkins, Gerard T; Webster, Mark W; Montarello, Joseph K; Delacroix, Sinny; Whitbourn, Robert J; Warren, Roderic J

2017-07-01

Catheter-based renal denervation for the treatment of drug-resistant hypertension has been intensively investigated in recent years. To date, only limited data have been published using multi-electrode radiofrequency ablation systems that can deliver lesions with a pre-determined pattern. This study was designed to evaluate the safety and performance of the second generation EnligHTN™ Renal Denervation System. This first-in-human, prospective, multi-center, non-randomized study included 39 patients (62% male, mean age 63 years, and mean baseline office blood pressure 174/93 mmHg) with drug-resistant hypertension. The primary safety and performance objectives were to characterize, from baseline to 6 months post procedure, the rate of serious procedural and device related adverse events, as adjudicated by an independent Clinical Events Committee, and the reduction of office systolic blood pressure. Renal artery denervation, using the second generation EnligHTN multi-electrode system significantly reduced office blood pressure from baseline to 1, 3, 6, 12, 18 and 24 months by 19/7, 26/9, 25/7, 23/7, 25/8 and 27/9 mmHg, respectively (p ≤ 0.0005). No serious device or procedure related adverse events affecting the renal arteries or renal function occurred through 24 months of follow-up. Renal sympathetic denervation using the second generation EnligHTN Renal Denervation System resulted in safe, rapid, and significant mean office blood pressure reduction that was sustained through 24 months. Future studies will need to address the utility of this system against an appropriate sham based comparator. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

Forest Structure Characterization Using JPL's UAVSAR Multi-Baseline Polarimetric SAR Interferometry and Tomography

NASA Technical Reports Server (NTRS)

Neumann, Maxim; Hensley, Scott; Lavalle, Marco; Ahmed, Razi

2013-01-01

This paper concerns forest remote sensing using JPL's multi-baseline polarimetric interferometric UAVSAR data. It presents exemplary results and analyzes the possibilities and limitations of using SAR Tomography and Polarimetric SAR Interferometry (PolInSAR) techniques for the estimation of forest structure. Performance and error indicators for the applicability and reliability of the used multi-baseline (MB) multi-temporal (MT) PolInSAR random volume over ground (RVoG) model are discussed. Experimental results are presented based on JPL's L-band repeat-pass polarimetric interferometric UAVSAR data over temperate and tropical forest biomes in the Harvard Forest, Massachusetts, and in the La Amistad Park, Panama and Costa Rica. The results are partially compared with ground field measurements and with air-borne LVIS lidar data.

Forest Structure Characterization Using Jpl's UAVSAR Multi-Baseline Polarimetric SAR Interferometry and Tomography

NASA Technical Reports Server (NTRS)

Neumann, Maxim; Hensley, Scott; Lavalle, Marco; Ahmed, Razi

2013-01-01

This paper concerns forest remote sensing using JPL's multi-baseline polarimetric interferometric UAVSAR data. It presents exemplary results and analyzes the possibilities and limitations of using SAR Tomography and Polarimetric SAR Interferometry (PolInSAR) techniques for the estimation of forest structure. Performance and error indicators for the applicability and reliability of the used multi-baseline (MB) multi-temporal (MT) PolInSAR random volume over ground (RVoG) model are discussed. Experimental results are presented based on JPL's L-band repeat-pass polarimetric interferometric UAVSAR data over temperate and tropical forest biomes in the Harvard Forest, Massachusetts, and in the La Amistad Park, Panama and Costa Rica. The results are partially compared with ground field measurements and with air-borne LVIS lidar data.

Analytical Solution of the Radiative Transfer Equation in a Thin Dusty Circumstellar Shell

NASA Astrophysics Data System (ADS)

Cruzalèbes, P.; Sacuto, S.

The radiative transfer equation can be solved analytically for optically thin shells. The solution leads to a semi-analytical expression of the visibility function, which can be compared to the numerical solution given by the DUSTY code. Best-fit model parameters are given using real measurements of ISO fluxes, ISI and VLTI-MIDI visibilities for 3 late-type stars.

Into the Modelling of RU Vir

NASA Astrophysics Data System (ADS)

Rau, G.; Hron, J.; Paladini, C.; Eriksson, K.; Aringer, B.; Groenewegen, M. A. T.; Mečina, M.

2015-08-01

We present an attempt to model the atmosphere of the carbon-rich Mira star RU Vir, using different techniques including spectroscopy, photometry, and interferometry. A radiative transfer code and hydrostatic model atmospheres were used for a preliminary study. To investigate the dynamic processes happening in RU Vir, dynamic model atmospheres were compared to new MIDI/VLTI observations obtained in April 2014, and SiC opacities were added.

The Perfect Science Machine

NASA Astrophysics Data System (ADS)

2008-05-01

ESO celebrates 10 years since First Light of the VLT Today marks the 10th anniversary since First Light with ESO's Very Large Telescope (VLT), the most advanced optical telescope in the world. Since then, the VLT has evolved into a unique suite of four 8.2-m Unit Telescopes (UTs) equipped with no fewer than 13 state-of-the-art instruments, and four 1.8-m moveable Auxiliary Telescopes (ATs). The telescopes can work individually, and they can also be linked together in groups of two or three to form a giant 'interferometer' (VLTI), allowing astronomers to see details corresponding to those from a much larger telescope. Green Flash at Paranal ESO PR Photo 16a/08 The VLT 10th anniversary poster "The Very Large Telescope array is a flagship facility for astronomy, a perfect science machine of which Europe can be very proud," says Tim de Zeeuw, ESO's Director General. "We have built the most advanced ground-based optical observatory in the world, thanks to the combination of a long-term adequately-funded instrument and technology development plan with an approach where most of the instruments were built in collaboration with institutions in the member states, with in-kind contributions in labour compensated by guaranteed observing time." Sitting atop the 2600m high Paranal Mountain in the Chilean Atacama Desert, the VLT's design, suite of instruments, and operating principles set the standard for ground-based astronomy. It provides the European scientific community with a telescope array with collecting power significantly greater than any other facilities available at present, offering imaging and spectroscopy capabilities at visible and infrared wavelengths. Blue Flash at Paranal ESO PR Photo 16b/08 A Universe of Discoveries The first scientifically useful images, marking the official 'First Light' of the VLT, were obtained on the night of 25 to 26 May 1998, with a test camera attached to "Antu", Unit Telescope number 1. They were officially presented to the press on the 27 May, exactly ten years ago. Since then, all four Unit Telescopes and four Auxiliary Telescopes went into routine operations and the number of instruments has continued to grow, to fill all the possible positions in the telescopes where instruments can be attached. In 2007, about 500 peer-reviewed papers using data collected with VLT and VLTI instruments at Paranal were published in scientific journals. Since the start of science operations, in April 1999, the VLT has led to the publication of more than 2200 refereed papers, an average of about one paper published every single working day. "The combination of high operational efficiency, system reliability and uptime for scientific observations results in very high scientific productivity," says Andreas Kaufer, director of the La Silla Paranal Observatory. The VLT and VLTI have contributed to all areas of astronomy, including the nature of dark matter and dark energy; the extreme physics of gamma-ray bursts and supernovae; the formation, structure and evolution of galaxies; the properties of exoplanets, Solar System objects, star clusters and stellar populations, the interstellar and intergalactic medium, and of super-massive black holes in galactic nuclei, in particular the one in the Galactic Centre; and the formation of stars and planets. The stunning scientific success of the VLT has attracted new member states to ESO. In the past decade Portugal joined (in 2001, after a ten-year associate status), followed by the United Kingdom (2002), Finland (2004), Spain (2006) and the Czech Republic (2007). Austria also announced its intent to join later this year. Another measure of success is the number of observing proposals made every year for the use of the VLT, which is now above the 1900 mark. On average, the amount of time requested to use the VLT is 6 times higher than what is available. The VLT will continue to increase in power over the next decade. The first of the second-generation VLT instruments, X-Shooter, will come online this year, with KMOS, SPHERE and MUSE to follow, together with multiple laser guide stars, an adaptive secondary mirror on Yepun (UT4), and one or more third-generation instruments, including an ultra-stable high-resolution spectrograph at the combined focus. The VLTI will also be equipped with second-generation instruments. Clearly, the VLT's story has only begun. More Information The VLT was designed from the start as an integrated system of four 8.2m telescopes, including the possibility to combine the light from individual telescopes for optical interferometry, enabling stupendous spatial resolution. First light on Antu occurred in May 1998, with Kueyen, Melipal and Yepun following soon after. Most of the VLT and VLTI instruments were built in close collaboration with institutes in the member states. The first-generation instrument suite was completed in 2007 with the commissioning of CRIRES. The Paranal arsenal includes turnkey adaptive optics systems and a rapid-response mode to react to fast transient events. Recently, the near-infrared imager HAWK-I was added as a 'generation-1.5' instrument.

OzDES multifibre spectroscopy for the Dark Energy Survey: 3-yr results and first data release

NASA Astrophysics Data System (ADS)

Childress, M. J.; Lidman, C.; Davis, T. M.; Tucker, B. E.; Asorey, J.; Yuan, F.; Abbott, T. M. C.; Abdalla, F. B.; Allam, S.; Annis, J.; Banerji, M.; Benoit-Lévy, A.; Bernard, S. R.; Bertin, E.; Brooks, D.; Buckley-Geer, E.; Burke, D. L.; Carnero Rosell, A.; Carollo, D.; Carrasco Kind, M.; Carretero, J.; Castander, F. J.; Cunha, C. E.; da Costa, L. N.; D'Andrea, C. B.; Doel, P.; Eifler, T. F.; Evrard, A. E.; Flaugher, B.; Foley, R. J.; Fosalba, P.; Frieman, J.; García-Bellido, J.; Glazebrook, K.; Goldstein, D. A.; Gruen, D.; Gruendl, R. A.; Gschwend, J.; Gupta, R. R.; Gutierrez, G.; Hinton, S. R.; Hoormann, J. K.; James, D. J.; Kessler, R.; Kim, A. G.; King, A. L.; Kovacs, E.; Kuehn, K.; Kuhlmann, S.; Kuropatkin, N.; Lagattuta, D. J.; Lewis, G. F.; Li, T. S.; Lima, M.; Lin, H.; Macaulay, E.; Maia, M. A. G.; Marriner, J.; March, M.; Marshall, J. L.; Martini, P.; McMahon, R. G.; Menanteau, F.; Miquel, R.; Moller, A.; Morganson, E.; Mould, J.; Mudd, D.; Muthukrishna, D.; Nichol, R. C.; Nord, B.; Ogando, R. L. C.; Ostrovski, F.; Parkinson, D.; Plazas, A. A.; Reed, S. L.; Reil, K.; Romer, A. K.; Rykoff, E. S.; Sako, M.; Sanchez, E.; Scarpine, V.; Schindler, R.; Schubnell, M.; Scolnic, D.; Sevilla-Noarbe, I.; Seymour, N.; Sharp, R.; Smith, M.; Soares-Santos, M.; Sobreira, F.; Sommer, N. E.; Spinka, H.; Suchyta, E.; Sullivan, M.; Swanson, M. E. C.; Tarle, G.; Uddin, S. A.; Walker, A. R.; Wester, W.; Zhang, B. R.

2017-11-01

We present results for the first three years of OzDES, a six year programme to obtain redshifts for objects in the Dark Energy Survey (DES) supernova fields using the 2dF fibre positioner and AAOmega spectrograph on the Anglo-Australian Telescope. OzDES is a multi-object spectroscopic survey targeting multiple types of targets at multiple epochs over a multiyear baseline and is one of the first multi-object spectroscopic surveys to dynamically include transients into the target list soon after their discovery. At the end of three years, OzDES has spectroscopically confirmed almost 100 supernovae, and has measured redshifts for 17 000 objects, including the redshifts of 2566 supernova hosts. We examine how our ability to measure redshifts for targets of various types depends on signal-to-noise ratio (S/N), magnitude and exposure time, finding that our redshift success rate increases significantly at a S/N of 2-3 per 1-Å bin. We also find that the change in S/N with exposure time closely matches the Poisson limit for stacked exposures as long as 10 h. We use these results to predict the redshift yield of the full OzDES survey, as well as the potential yields of future surveys on other facilities such as (i.e. the 4-m Multi-Object Spectroscopic Telescope, the Subaru Prime Focus Spectrograph and the Maunakea Spectroscopic Explorer). This work marks the first OzDES data release, comprising 14 693 redshifts. OzDES is on target to obtain over 30 000 redshifts over the 6-yr duration of the survey, including a yield of approximately 5700 supernova host-galaxy redshifts.

DEM generation in cloudy-rainy mountainous area with multi-baseline SAR interferometry

NASA Astrophysics Data System (ADS)

Wu, Hong'an; Zhang, Yonghong; Jiang, Decai; Kang, Yonghui

2018-03-01

Conventional singe baseline InSAR is easily affected by atmospheric artifacts, making it difficult to generate highprecision DEM. To solve this problem, in this paper, a multi-baseline interferometric phase accumulation method with weights fixed by coherence is proposed to generate higher accuracy DEM. The mountainous area in Kunming, Yunnan Province, China is selected as study area, which is characterized by cloudy weather, rugged terrain and dense vegetation. The multi-baseline InSAR experiments are carried out by use of four ALOS-2 PALSAR-2 images. The generated DEM is evaluated by Chinese Digital Products of Fundamental Geographic Information 1:50000 DEM. The results demonstrate that: 1) the proposed method can reduce atmospheric artifacts significantly; 2) the accuracy of InSAR DEM generated by six interferograms satisfies the standard of 1:50000 DEM Level Three and American DTED-1.

Extended envelopes around Galactic Cepheids. I. ℓ Carinae from near and mid-infrared interferometry with the VLTI

NASA Astrophysics Data System (ADS)

Kervella, P.; Mérand, A.; Perrin, G.; Coudé du Foresto, V.

2006-03-01

We present the results of long-baseline interferometric observations of the bright southern Cepheid ℓ Carinae in the infrared N (8-13 μm) and K (2.0-2.4 μm) bands, using the MIDI and VINCI instruments of the VLT Interferometer. We resolve in the N band a large circumstellar envelope (CSE) that we model with a Gaussian of 3 Rstar (≈500 R⊙ ≈ 2-3 AU) half width at half maximum. The signature of this envelope is also detected in our K band data as a deviation from a single limb darkened disk visibility function. The superimposition of a Gaussian CSE on the limb darkened disk model of the Cepheid star results in a significantly better fit of our VINCI data. The extracted CSE parameters in the K band are a half width at half maximum of 2 Rstar, comparable to the N band model, and a total brightness of 4% of the stellar photosphere. A possibility is that this CSE is linked to the relatively large mass loss rate of ℓ Car. Though its physical nature cannot be determined from our data, we discuss an analogy with the molecular envelopes of RV Tauri, red supergiants and Miras.

VLTI-AMBER Velocity-Resolved Aperture-Synthesis Imaging of Eta Carinae with a Spectral Resolution of 12 000: Studies of the Primary Star Wind and Innermost Wind-Wind Collision Zone

NASA Technical Reports Server (NTRS)

Weigelt, G.; Hofmann, K.-H.; Schertl, D.; Clementel, N.; Corcoran, M. F.; Damineli, A.; de Wit, W.-J.; Grellmann, R.; Groh, J.; Guieu, S.;

Analysis of surface EMG baseline for detection of hidden muscle activity

NASA Astrophysics Data System (ADS)

Zhang, Xu; Zhou, Ping

2014-02-01

Objective. This study explored the feasibility of detecting hidden muscle activity in surface electromyogram (EMG) baseline. Approach. Power spectral density (PSD) analysis and multi-scale entropy (MSE) analysis were used. Both analyses were applied to computer simulations of surface EMG baseline with the presence (representing activity data) or absence (representing reference data) of hidden muscle activity, as well as surface electrode array EMG baseline recordings of healthy control and amyotrophic lateral sclerosis (ALS) subjects. Main results. Although the simulated reference data and the activity data yielded no distinguishable difference in the time domain, they demonstrated a significant difference in the frequency and signal complexity domains with the PSD and MSE analyses. For a comparison using pooled data, such a difference was also observed when the PSD and MSE analyses were applied to surface electrode array EMG baseline recordings of healthy control and ALS subjects, which demonstrated no distinguishable difference in the time domain. Compared with the PSD analysis, the MSE analysis appeared to be more sensitive for detecting the difference in surface EMG baselines between the two groups. Significance. The findings implied the presence of a hidden muscle activity in surface EMG baseline recordings from the ALS subjects. To promote the presented analysis as a useful diagnostic or investigatory tool, future studies are necessary to assess the pathophysiological nature or origins of the hidden muscle activity, as well as the baseline difference at the individual subject level.

Analysis of Surface EMG Baseline for Detection of Hidden Muscle Activity

PubMed Central

Zhang, Xu; Zhou, Ping

2014-01-01

Objective This study explored the feasibility of detecting hidden muscle activity in surface electromyogram (EMG) baseline. Approach Power spectral density (PSD) analysis and multi-scale entropy (MSE) analysis were used respectively. Both analyses were applied to computer simulations of surface EMG baseline with presence (representing activity data) or absence (representing reference data) of hidden muscle activity, as well as surface electrode array EMG baseline recordings of healthy control and amyotrophic lateral sclerosis (ALS) subjects. Main results Although the simulated reference data and the activity data yielded no distinguishable difference in the time domain, they demonstrated a significant difference in the frequency and signal complexity domains with the PSD and MSE analyses. For a comparison using pooled data, such a difference was also observed when the PSD and MSE analyses were applied to surface electrode array EMG baseline recordings of healthy control and ALS subjects, which demonstrated no distinguishable difference in the time domain. Compared with the PSD analysis, the MSE analysis appeared to be more sensitive for detecting the difference in surface EMG baselines between the two groups. Significance The findings implied presence of hidden muscle activity in surface EMG baseline recordings from the ALS subjects. To promote the presented analysis as a useful diagnostic or investigatory tool, future studies are necessary to assess the pathophysiological nature or origins of the hidden muscle activity, as well as the baseline difference at the individual subject level. PMID:24445526

Double Engine for a Nebula

NASA Astrophysics Data System (ADS)

2009-08-01

ESO has just released a stunning new image of a field of stars towards the constellation of Carina (the Keel). This striking view is ablaze with a flurry of stars of all colours and brightnesses, some of which are seen against a backdrop of clouds of dust and gas. One unusual star in the middle, HD 87643, has been extensively studied with several ESO telescopes, including the Very Large Telescope Interferometer (VLTI). Surrounded by a complex, extended nebula that is the result of previous violent ejections, the star has been shown to have a companion. Interactions in this double system, surrounded by a dusty disc, may be the engine fuelling the star's remarkable nebula. The new image, showing a very rich field of stars towards the Carina arm of the Milky Way, is centred on the star HD 87643, a member of the exotic class of B[e] stars [1]. It is part of a set of observations that provide astronomers with the best ever picture of a B[e] star. The image was obtained with the Wide Field Imager (WFI) attached to the MPG/ESO 2.2-metre telescope at the 2400-metre-high La Silla Observatory in Chile. The image shows beautifully the extended nebula of gas and dust that reflects the light from the star. The central star's wind appears to have shaped the nebula, leaving bright, ragged tendrils of gas and dust. A careful investigation of these features seems to indicate that there are regular ejections of matter from the star every 15 to 50 years. A team of astronomers, led by Florentin Millour, has studied the star HD 87643 in great detail, using several of ESO's telescopes. Apart from the WFI, the team also used ESO's Very Large Telescope (VLT) at Paranal. At the VLT, the astronomers used the NACO adaptive optics instrument, allowing them to obtain an image of the star free from the blurring effect of the atmosphere. To probe the object further, the team then obtained an image with the Very Large Telescope Interferometer (VLTI). The sheer range of this set of observations, from the panoramic WFI image to the fine detail of the VLTI observations, corresponds to a zoom-in factor of 60 000 between the two extremes. The astronomers found that HD 87643 has a companion located at about 50 times the Earth-Sun distance and is embedded in a compact dust shell. The two stars probably orbit each other in a period between 20 and 50 years. A dusty disc may also be surrounding the two stars. The presence of the companion could be an explanation for the regular ejection of matter from the star and the formation of the nebula: as the companion moves on a highly elliptical orbit, it would regularly come very close to HD 87643, triggering an ejection. Notes [1]: B[e] stars are stars of spectral type B, with emission lines in their spectra, hence the "e". They are surrounded by a large amount of dust. More information The work on HD 87643 has been published in a paper to appear in Astronomy and Astrophysics: A binary engine fueling HD 87643's complex circumstellar environment using AMBER/VLTI imaging, by F. Millour et al. ESO, the European Southern Observatory, is the foremost intergovernmental astronomy organisation in Europe and the world's most productive astronomical observatory. It is supported by 14 countries: Austria, Belgium, the Czech Republic, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. ESO carries out an ambitious programme focused on the design, construction and operation of powerful ground-based observing facilities enabling astronomers to make important scientific discoveries. ESO also plays a leading role in promoting and organising cooperation in astronomical research. ESO operates three unique world-class observing sites in Chile: La Silla, Paranal and Chajnantor. At Paranal, ESO operates the Very Large Telescope, the world's most advanced visible-light astronomical observatory. ESO is the European partner of a revolutionary astronomical telescope ALMA, the largest astronomical project in existence. ESO is currently planning a 42-metre European Extremely Large optical/near-infrared Telescope, the E-ELT, which will become "the world's biggest eye on the sky".

Comparison of an objective method of measuring bulbar redness to the use of traditional grading scales.

PubMed

Sorbara, Luigina; Simpson, Trefford; Duench, Stephanie; Schulze, Marc; Fonn, Desmond

2007-03-01

The primary objective was to compare measures of bulbar redness objectively using a photometric method with standard grading methods. Measures of redness were made on 24 participants wearing a silicone hydrogel contact lens in one eye for overnight wear. This report compares hyperaemia after 1 week of daily wear (baseline) with redness measured after 6 months of overnight wear. A new method of objectively measuring bulbar conjunctival redness was performed using the Spectrascan650 Photometer by Photo Research under fixed illumination. Photometric measures in CIEu(*) chromaticity values involve the measurement of chromaticity, a physical analogue of redness, greenness and blueness in the image. This method was validated in Part 1 of the study using repeated measurements on the photographic CCLRU scale. In Part 2 of the study, the photographic grading scale (CCLRU) from 0 (none) to 100 (extreme) was used to make the comparison. Part 1 indicated that the photometer provides a repeatable and reliable measure of bulbar redness (CCC=0.989). A moderately strong and significant correlation was found between the CIEu(*) chromaticity values and the analogue data (R=0.795, p=0.000) at each measurement session (from baseline to 1 day, 1 week, and 1, 3 and 6 months of overnight wear). This new standardized and objective method of measuring bulbar redness has great potential to replace subjective grading scales, especially with multi-centre studies, where variability between investigators occurs. This method may also detect smaller changes between visits or between eyes.

Method, system, and computer-readable medium for determining performance characteristics of an object undergoing one or more arbitrary aging conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gering, Kevin L.

A method, system, and computer-readable medium are described for characterizing performance loss of an object undergoing an arbitrary aging condition. Baseline aging data may be collected from the object for at least one known baseline aging condition over time, determining baseline multiple sigmoid model parameters from the baseline data, and performance loss of the object may be determined over time through multiple sigmoid model parameters associated with the object undergoing the arbitrary aging condition using a differential deviation-from-baseline approach from the baseline multiple sigmoid model parameters. The system may include an object, monitoring hardware configured to sample performance characteristics ofmore » the object, and a processor coupled to the monitoring hardware. The processor is configured to determine performance loss for the arbitrary aging condition from a comparison of the performance characteristics of the object deviating from baseline performance characteristics associated with a baseline aging condition.« less

Cardiovascular risk factors in multi-ethnic middle school students: the HEALTHY primary prevention trial.

PubMed

Willi, S M; Hirst, K; Jago, R; Buse, J; Kaufman, F; El Ghormli, L; Bassin, S; Elliot, D; Hale, D E

2012-06-01

The objective of this study was to examine the effects of an integrated, multi-component, school-based intervention programme on cardiovascular disease (CVD) risk factors among a multi-ethnic cohort of middle school students. HEALTHY was a cluster randomized, controlled, primary prevention trial. Middle school was the unit of randomization and intervention. Half of the schools were assigned to an intervention programme consisting of changes in the total school food environment and physical education classes, enhanced by educational outreach and behaviour change activities and promoted by a social marketing campaign consisting of reinforcing messages and images. Outcome data reported (anthropometrics, blood pressure and fasting lipid levels) were collected on a cohort of students enrolled at the start of 6th grade (∼11-12 years old) and followed to end of 8th grade (∼13-14 years old). Forty-two middle schools were enrolled at seven field centres; 4363 students provided both informed consent and CVD data at baseline and end of study. The sample was 52.7% female, 54.5% Hispanic, 17.6% non-Hispanic Black, 19.4% non-Hispanic White and 8.5% other racial/ethnic combinations, and 49.6% were categorized as overweight or obese (body mass index ≥ 85th percentile) at baseline. A significant intervention effect was detected in the prevalence of hypertension in non-Hispanic Black and White males. The intervention produced no significant changes in lipid levels. The prevalence of some CVD risk factors is high in minority middle school youth, particularly males. A multi-component, school-based programme achieved only modest reductions in these risk factors; however, promising findings occurred in non-Hispanic Black and White males with hypertension. © 2012 The Authors. Pediatric Obesity © 2012 International Association for the Study of Obesity.

Exploring associations between self-regulatory mechanisms and neuropsychological functioning and driver behaviour after brain injury.

PubMed

Rike, Per-Ola; Johansen, Hans J; Ulleberg, Pål; Lundqvist, Anna; Schanke, Anne-Kristine

2018-04-01

The objective of this prospective one-year follow-up study was to explore the associations between self-regulatory mechanisms and neuropsychological tests as well as baseline and follow-up ratings of driver behaviour. The participants were a cohort of subjects with stroke and traumatic brain injury (TBI) who were found fit to drive after a multi-disciplinary driver assessment (baseline). Baseline measures included neuropsychological tests and ratings of self-regulatory mechanisms, i.e., executive functions (Behavior Rating Inventory of Executive Function-Adult Version; BRIEF-A) and impulsive personality traits (UPPS Impulsive Behavior Scale). The participants rated pre-injury driving behaviour on the Driver Behaviour Qestionnaire (DBQ) retrospectively at baseline and after one year of post-injury driving (follow-up). Better performance on neuropsychological tests was significantly associated with more post-injury DBQ Violations. The BRIEF-A main indexes were significantly associated with baseline and follow-up ratings of DBQ Mistakes and follow-up DBQ Inattention. UPPS (lack of) Perseverance was significantly associated with baseline DBQ Inattention, whereas UPPS Urgency was significantly associated with baseline DBQ Inexperience and post-injury DBQ Mistakes. There were no significant changes in DBQ ratings from baseline (pre-injury) to follow-up (post-injury). It was concluded that neuropsychological functioning and self-regulatory mechanisms are related to driver behaviour. Some aspects of driver behaviour do not necessarily change after brain injury, reflecting the influence of premorbid driving behaviour or impaired awareness of deficits on post-injury driving behaviour. Further evidence is required to predict the role of self-regulatory mechanisms on driver behaviour and crashes or near misses.

Dynamics during outburst. VLTI observations of the young eruptive star V1647 Orionis during its 2003-2006 outburst

NASA Astrophysics Data System (ADS)

Mosoni, L.; Sipos, N.; Ábrahám, P.; Moór, A.; Kóspál, Á.; Henning, Th.; Juhász, A.; Kun, M.; Leinert, Ch.; Quanz, S. P.; Ratzka, Th.; Schegerer, A. A.; van Boekel, R.; Wolf, S.

2013-04-01

Context. It is hypothesized that low-mass young stellar objects undergo eruptive phases during their early evolution. These eruptions are thought to be caused by highly increased mass accretion from the disk onto the star, and therefore play an important role in the early evolution of Sun-like stars, of their circumstellar disks (structure, dust composition), and in the formation of their planetary systems. The outburst of V1647 Ori between 2003 and 2006 offered a rare opportunity to investigate such an accretion event. Aims: By means of our interferometry observing campaign during this outburst, supplemented by other observations, we investigate the temporal evolution of the inner circumstellar structure of V1647 Ori, the region where Earth-like planets could be born. We also study the role of the changing extinction in the brightening of the object and separate it from the accretional brightening. Methods: We observed V1647 Ori with MIDI on the VLTI at two epochs in this outburst. First, during the slowly fading plateau phase (2005 March) and second, just before the rapid fading of the object (2005 September), which ended the outburst. We used the radiative transfer code MC3D to fit the interferometry data and the spectral energy distributions from five different epochs at different stages of the outburst. The comparison of these models allowed us to trace structural changes in the system on AU-scales. We also considered qualitative alternatives for the interpretation of our data. Results: We found that the disk and the envelope are similar to those of non-eruptive young stars and that the accretion rate varied during the outburst. We also found evidence for the increase of the inner radii of the circumstellar disk and envelope at the beginning of the outburst. Furthermore, the change of the interferometric visibilities indicates structural changes in the circumstellar material. We test a few scenarios to interpret these data. We also speculate that the changes are caused by the fading of the central source, which is not immediately followed by the fading of the outer regions. Conclusions: We found that most of our results fit in the canonical picture of young eruptive stars. Our study provided dynamical information from the regions of the innermost few AU of the system: changes of the inner radii of the disk and envelope. However, if the delay in the fading of the disk is responsible for the changes seen in the MIDI data, the effect should be confirmed by dynamical modeling. Based on observations made with ESO telescopes at the Paranal Observatory under program IDs 274.C-5026 and 076.C-0736. In addition, this work is based in part on archival data obtained with the Spitzer Space Telescope, which is operated by the Jet Propulsion Laboratory, California Institute of Technology under a contract with NASA.

A visual tracking method based on deep learning without online model updating

NASA Astrophysics Data System (ADS)

Tang, Cong; Wang, Yicheng; Feng, Yunsong; Zheng, Chao; Jin, Wei

2018-02-01

The paper proposes a visual tracking method based on deep learning without online model updating. In consideration of the advantages of deep learning in feature representation, deep model SSD (Single Shot Multibox Detector) is used as the object extractor in the tracking model. Simultaneously, the color histogram feature and HOG (Histogram of Oriented Gradient) feature are combined to select the tracking object. In the process of tracking, multi-scale object searching map is built to improve the detection performance of deep detection model and the tracking efficiency. In the experiment of eight respective tracking video sequences in the baseline dataset, compared with six state-of-the-art methods, the method in the paper has better robustness in the tracking challenging factors, such as deformation, scale variation, rotation variation, illumination variation, and background clutters, moreover, its general performance is better than other six tracking methods.

Feature-fused SSD: fast detection for small objects

NASA Astrophysics Data System (ADS)

Cao, Guimei; Xie, Xuemei; Yang, Wenzhe; Liao, Quan; Shi, Guangming; Wu, Jinjian

2018-04-01

Small objects detection is a challenging task in computer vision due to its limited resolution and information. In order to solve this problem, the majority of existing methods sacrifice speed for improvement in accuracy. In this paper, we aim to detect small objects at a fast speed, using the best object detector Single Shot Multibox Detector (SSD) with respect to accuracy-vs-speed trade-off as base architecture. We propose a multi-level feature fusion method for introducing contextual information in SSD, in order to improve the accuracy for small objects. In detailed fusion operation, we design two feature fusion modules, concatenation module and element-sum module, different in the way of adding contextual information. Experimental results show that these two fusion modules obtain higher mAP on PASCAL VOC2007 than baseline SSD by 1.6 and 1.7 points respectively, especially with 2-3 points improvement on some small objects categories. The testing speed of them is 43 and 40 FPS respectively, superior to the state of the art Deconvolutional single shot detector (DSSD) by 29.4 and 26.4 FPS.

The Great Cometary Show

NASA Astrophysics Data System (ADS)

2007-01-01

The ESO Very Large Telescope Interferometer, which allows astronomers to scrutinise objects with a precision equivalent to that of a 130-m telescope, is proving itself an unequalled success every day. One of the latest instruments installed, AMBER, has led to a flurry of scientific results, an anthology of which is being published this week as special features in the research journal Astronomy & Astrophysics. ESO PR Photo 06a/07 ESO PR Photo 06a/07 The AMBER Instrument "With its unique capabilities, the VLT Interferometer (VLTI) has created itself a niche in which it provide answers to many astronomical questions, from the shape of stars, to discs around stars, to the surroundings of the supermassive black holes in active galaxies," says Jorge Melnick (ESO), the VLT Project Scientist. The VLTI has led to 55 scientific papers already and is in fact producing more than half of the interferometric results worldwide. "With the capability of AMBER to combine up to three of the 8.2-m VLT Unit Telescopes, we can really achieve what nobody else can do," added Fabien Malbet, from the LAOG (France) and the AMBER Project Scientist. Eleven articles will appear this week in Astronomy & Astrophysics' special AMBER section. Three of them describe the unique instrument, while the other eight reveal completely new results about the early and late stages in the life of stars. ESO PR Photo 06b/07 ESO PR Photo 06b/07 The Inner Winds of Eta Carinae The first results presented in this issue cover various fields of stellar and circumstellar physics. Two papers deal with very young solar-like stars, offering new information about the geometry of the surrounding discs and associated outflowing winds. Other articles are devoted to the study of hot active stars of particular interest: Alpha Arae, Kappa Canis Majoris, and CPD -57o2874. They provide new, precise information about their rotating gas envelopes. An important new result concerns the enigmatic object Eta Carinae. Using AMBER with its high spatial and spectral resolution, it was possible to zoom into the very heart of this very massive star. In this innermost region, the observations are dominated by the extremely dense stellar wind that totally obscures the underlying central star. The AMBER observations show that this dense stellar wind is not spherically symmetric, but exhibits a clearly elongated structure. Overall, the AMBER observations confirm that the extremely high mass loss of Eta Carinae's massive central star is non-spherical and much stronger along the poles than in the equatorial plane. This is in agreement with theoretical models that predict such an enhanced polar mass-loss in the case of rapidly rotating stars. ESO PR Photo 06c/07 ESO PR Photo 06c/07 RS Ophiuchi in Outburst Several papers from this special feature focus on the later stages in a star's life. One looks at the binary system Gamma 2 Velorum, which contains the closest example of a star known as a Wolf-Rayet. A single AMBER observation allowed the astronomers to separate the spectra of the two components, offering new insights in the modeling of Wolf-Rayet stars, but made it also possible to measure the separation between the two stars. This led to a new determination of the distance of the system, showing that previous estimates were incorrect. The observations also revealed information on the region where the winds from the two stars collide. The famous binary system RS Ophiuchi, an example of a recurrent nova, was observed just 5 days after it was discovered to be in outburst on 12 February 2006, an event that has been expected for 21 years. AMBER was able to detect the extension of the expanding nova emission. These observations show a complex geometry and kinematics, far from the simple interpretation of a spherical fireball in extension. AMBER has detected a high velocity jet probably perpendicular to the orbital plane of the binary system, and allowed a precise and careful study of the wind and the shockwave coming from the nova. The stream of results from the VLTI and AMBER is no doubt going to increase in the coming years with the availability of new functionalities. "In addition to the 8.2-m Unit Telescopes, the VLTI can also combine the light from up to 4 movable 1.8-m Auxiliary Telescopes. AMBER fed by three of these AT's will be offered to the user community as of April this year, and from October we will also make FINITO available," said Melnick. "This 'fringe-tracking' device allows us to stabilise changes in the atmospheric conditions and thus to substantially improve the efficiency of the observations. By effectively 'freezing' the interferometric fringes, FINITO allows astronomers to significantly increase the exposure times." The Astronomy & Astrophysics special feature (volume 464 - March II 2007) on AMBER first results includes 11 articles. They are freely available on the A&A web site.

Hypercat - Hypercube of AGN tori

NASA Astrophysics Data System (ADS)

Nikutta, Robert; Lopez-Rodriguez, Enrique; Ichikawa, Kohei; Levenson, Nancy A.; Packham, Christopher C.

2018-06-01

AGN unification and observations hold that a dusty torus obscures the central accretion engine along some lines of sight. SEDs of dust tori have been modeled for a long time, but resolved emission morphologies have not been studied in much detail, because resolved observations are only possible recently (VLTI,ALMA) and in the near future (TMT,ELT,GMT). Some observations challenge a simple torus model, because in several objects most of MIR emission appears to emanate from polar regions high above the equatorial plane, i.e. not where the dust supposedly resides.We introduce our software framework and hypercube of AGN tori (Hypercat) made with CLUMPY (www.clumpy.org), a large set of images (6 model parameters + wavelength) to facilitate studies of emission and dust morphologies. We make use of Hypercat to study the morphological properties of the emission and dust distributions as function of model parameters. We find that a simple clumpy torus can indeed produce 10-micron emission patterns extended in polar directions, with extension ratios compatible with those found in observations. We are able to constrain the range of parameters that produce such morphologies.

Modelling a set of C-rich AGB stars: the cases of RU Vir and R Lep

NASA Astrophysics Data System (ADS)

Rau, G.; Paladini, C.; Hron, J.; Aringer, B.; Groenewegen, M. A. T.; Nowotny, W.

We study the atmospheres of a set of carbon-rich asymptotic giant branch AGB stars to improve our understanding of the dynamic processes happening there. We compare in a systematic way spectrometric, photometric and mid-infrared (VLTI/MIDI) interferometric measurements with different types of model atmospheres: (1) hydrostatic models + MOD-dusty models added a posteriori; (2) self-consistent dynamic model atmospheres. These allow us to interpret in a coherent way the dynamic behavior of gas and dust. The results underline that the joint use of different kinds of observations, as photometry, spectroscopy and interferometry, is essential for understanding the atmospheres of pulsating C-rich AGB stars. For our first target, the carbon-rich Mira star RU Vir, the dynamic model atmospheres fit well the ISO/SWS spectrum in the wavelength range lambda = [2.9, 13.0] mu m. However, the object turned out to be somehow ''peculiar''. The other target we present is R Lep. Here the agreement between models and observations is much better although the MIDI data at 11.4 mu m cannot be properly modelled.

X-43D Conceptual Design and Feasibility Study

NASA Technical Reports Server (NTRS)

Johnson, Donald B.; Robinson, Jeffrey S.

2005-01-01

NASA s Next Generation Launch Technology (NGLT) Program, in conjunction with the office of the Director of Defense Research and Engineering (DDR&E), developed an integrated hypersonic technology demonstration roadmap. This roadmap is an integral part of the National Aerospace Initiative (NAI), a multi-year, multi-agency cooperative effort to invest in and develop, among other things, hypersonic technologies. This roadmap contains key ground and flight demonstrations required along the path to developing a reusable hypersonic space access system. One of the key flight demonstrations required for systems that will operate in the high Mach number regime is the X-43D. As currently conceived, the X-43D is a Mach 15 flight test vehicle that incorporates a hydrogen-fueled scramjet engine. The purpose of the X-43D is to gather high Mach number flight environment and engine operability information which is difficult, if not impossible, to gather on the ground. During 2003, the NGLT Future Hypersonic Flight Demonstration Office initiated a feasibility study on the X-43D. The objective of the study was to develop a baseline conceptual design, assess its performance, and identify the key technical issues. The study also produced a baseline program plan, schedule, and cost, along with a list of key programmatic risks.

The Association of Calcium Supplementation and Incident Cardiovascular Events in the Multi-Ethnic Study of Atherosclerosis (MESA)

PubMed Central

Hsu, F.C.; de Boer, I.H.; Ix, J.H.; Siscovick, D.; Szklo, M.; Burke, G.L.; Frazier-Wood, A.C.; Herrington, D.M.

2016-01-01

Background and Aims Many US adults use calcium supplements to address inadequate dietary intake and improve bone health. However, recent reports have suggested that use of calcium supplements may elevate cardiovascular disease (CVD) risk. In this study, we examined associations between baseline calcium supplement use and incident myocardial infarction (MI) (n=208 events) and CVD events (n=641 events) over 10.3 years in men and women from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort (n=6,236), with dietary calcium intake at baseline also examined as a supplementary objective. Methods and Results Using Cox proportional hazards models, no compelling associations between calcium intake from supplements or diet and incident CVD events were observed upon multivariate adjustment for potential confounders. An association with lower MI risk was observed comparing those with low levels of calcium supplement use (1-499 mg) to those using no calcium supplements (hazard ratio 0.69, 95% CI 0.48, 0.98, p=0.039). Relationships were homogeneous by gender, race/ethnicity, or chronic kidney disease. Results were also similar when the analysis was limited to postmenopausal women only. Conclusion Analysis of incident MI and CVD events in the MESA cohort does not support a substantial association of calcium supplement use with negative cardiovascular outcomes. PMID:27514606

Longitudinal MRI findings from the vitamin E and Donepezil treatment study for MCI

PubMed Central

Jack, Clifford R.; Petersen, Ronald C.; Grundman, Michael; Jin, Shelia; Gamst, Anthony; Ward, Chadwick P.; Sencakova, Drahomira; Doody, Rachelle S.; Thal, Leon J.

2009-01-01

The vitamin E and donepezil trial for the treatment of amnestic mild cognitive impairment (MCI) was conducted at 69 centers in North America; 24 centers participated in an MRI sub study. The objective of this study was to evaluate the effect of treatment on MRI atrophy rates; and validate rate measures from serial MRI as indicators of disease progression in multi center therapeutic trials for MCI. Annual percent change (APC) from baseline to follow-up was measured for hippocampus, entorhinal cortex, whole brain, and ventricle in the 131 subjects who remained in the treatment study and completed technically satisfactory baseline and follow-up scans. Although a non-significant trend toward slowing of hippocampal atrophy rates was seen in APOE ∈4 carriers treated with donepezil; no treatment effect was confirmed for any MRI measure in either treatment group. For each of the four brain atrophy rate measures, APCs were greater in subjects who converted to AD than non-converters, and were greater in APOE ∈4 carriers than non-carriers. MRI APCs and changes in cognitive test performance were uniformly correlated in the expected direction (all p < 0.000). Results of this study support the feasibility of using MRI as an outcome measure of disease progression in multi center therapeutic trials for MCI. PMID:17452062

Built environment change and change in BMI and waist circumference: Multi-ethnic Study of Atherosclerosis.

PubMed

Hirsch, Jana A; Moore, Kari A; Barrientos-Gutierrez, Tonatiuh; Brines, Shannon J; Zagorski, Melissa A; Rodriguez, Daniel A; Diez Roux, Ana V

2014-11-01

To examine longitudinal associations of the neighborhood built environment with objectively measured body mass index (BMI) and waist circumference (WC) in a geographically and racial/ethnically diverse group of adults. This study used data from 5,506 adult participants in the Multi-Ethnic Study of Atherosclerosis, aged 45-84 years in 2000 (baseline). BMI and WC were assessed at baseline and four follow-up visits (median follow-up 9.1 years). Time-varying built environment measures (population density, land-use, destinations, bus access, and street characteristics) were created using Geographic Information Systems. Principal components analysis was used to derive composite scores for three built environment factors. Fixed-effects models, tightly controlling for all time-invariant characteristics, estimated associations between change in the built environment, and change in BMI and WC. Increases in the intensity of development (higher density of walking destinations and population density, and lower percent residential) were associated with less pronounced increases or decreases over time in BMI and WC. Changes in connected retail centers (higher percent retail, higher street connectivity) and public transportation (distance to bus) were not associated with changes in BMI or WC. Longitudinal changes in the built environment, particularly increased density, are associated with decreases in BMI and WC. © 2014 The Obesity Society.

MWC 297: a young high-mass star rotating at critical velocity

NASA Astrophysics Data System (ADS)

Acke, B.; Verhoelst, T.; van den Ancker, M. E.; Deroo, P.; Waelkens, C.; Chesneau, O.; Tatulli, E.; Benisty, M.; Puga, E.; Waters, L. B. F. M.; Verhoeff, A.; de Koter, A.

2008-07-01

Context: MWC 297 is a nearby young massive B[e] star. The central star is attenuated by 8 mag in the optical and has a high projected rotational velocity of 350 km s-1. Despite the wealth of published observations, the nature of this object and its circumstellar environment is not understood very well. Aims: With the present paper, we intend to shed light on the geometrical structure of the circumstellar matter that is responsible for the near- to mid-infrared flux excess. Methods: The H-band (1.6-2.0 μm), K-band (2.0-2.5 μm), and N-band (8-13 μm) brightness distribution of MWC 297 was probed with the ESO interferometric spectrographs AMBER and MIDI, mounted on the VLTI in Paranal, Chile. We obtained visibility measurements on 3 AMBER and 12 MIDI baselines, covering a wide range of spatial frequencies. Different models (parametrized circumstellar disks, a dusty halo) were invoked to fit the data, all of which fail to do so in a satisfying way. We approximated the brightness distribution in H, K, and N with a geometric model consisting of three Gaussian disks with different extents and brightness temperatures. This model can account for the entire near- to mid-IR emission of MWC 297. Results: The circumstellar matter around MWC 297 is resolved on all baselines. The near- and mid-IR emission, including the silicate emission at 10 micron, emanates from a very compact region (FWHM < 1.5 AU) around the central star. Conclusions: We argue that the extinction towards the MWC 297 star+disk system is interstellar and most likely due to remnants of the natal cloud from which MWC 297 was formed. Furthermore, we argue that the circumstellar matter in the MWC 297 system is organized in a circumstellar disk, seen under moderate (i < 40°) inclination. The disk displays no inner emission-free gap at the resolution of our interferometric observations. The low inclination of the disk implies that the already high projected rotational velocity of the star corresponds to an actual rotational velocity that exceeds the critical velocity of the star. This result shows that stars can obtain such high rotation rates at birth. We discuss the impact of this result in terms of the formation of high-mass stars and the main-sequence evolution of classical Be stars. Based on observations made with ESO telescopes at the La Silla Paranal Observatory under program IDs 077.D-0071(B-C), 077.D-0095(C-F), 079.C-0012(A-H) and 079.C-0207(A).

Adaptive surrogate model based multi-objective transfer trajectory optimization between different libration points

NASA Astrophysics Data System (ADS)

Peng, Haijun; Wang, Wei

2016-10-01

An adaptive surrogate model-based multi-objective optimization strategy that combines the benefits of invariant manifolds and low-thrust control toward developing a low-computational-cost transfer trajectory between libration orbits around the L1 and L2 libration points in the Sun-Earth system has been proposed in this paper. A new structure for a multi-objective transfer trajectory optimization model that divides the transfer trajectory into several segments and gives the dominations for invariant manifolds and low-thrust control in different segments has been established. To reduce the computational cost of multi-objective transfer trajectory optimization, a mixed sampling strategy-based adaptive surrogate model has been proposed. Numerical simulations show that the results obtained from the adaptive surrogate-based multi-objective optimization are in agreement with the results obtained using direct multi-objective optimization methods, and the computational workload of the adaptive surrogate-based multi-objective optimization is only approximately 10% of that of direct multi-objective optimization. Furthermore, the generating efficiency of the Pareto points of the adaptive surrogate-based multi-objective optimization is approximately 8 times that of the direct multi-objective optimization. Therefore, the proposed adaptive surrogate-based multi-objective optimization provides obvious advantages over direct multi-objective optimization methods.

In vivo optimisation study for multi-baseline MR-based thermometry in the context of hyperthermia using MR-guided high intensity focused ultrasound for head and neck applications.

PubMed

Pichardo, Samuel; Köhler, Max; Lee, Justin; Hynnyen, Kullervo

2014-12-01

In this in vivo study, the feasibility to perform hyperthermia treatments in the head and neck using magnetic resonance image-guided high intensity focused ultrasound (MRgHIFU) was established using a porcine acute model. Porcine specimens with a weight between 17 and 18 kg were treated in the omohyoid muscle in the neck. Hyperthermia was applied with a target temperature of 41 °C for 30 min using a Sonalleve MRgHIFU system. MR-based thermometry was calculated using water-proton resonance frequency shift and multi-baseline look-up tables indexed by peak-to-peak displacement (Dpp) measurements using a pencil-beam navigator. Three hyperthermia experiments were conducted at different Dpp values of 0.2, 1.0 and 3.0 mm. An optimisation study was carried out to establish the optimal parameters controlling the multi-baseline method that ensured a minimisation of spatial-average peak-to-peak temperature (TSA-pp) and temperature direct current bias (TSA-DC). The multi-baseline technique reduced considerably the noise on both TSA-pp and TSA-DC. The reduction of noise was more important when Dpp was higher. For Dpp = 3 mm the average (±standard deviation (SD)) of TSA-pp and TSA-DC was reduced from 4.5 (± 2.5) and 2.5 (±0.6) °C, respectively, to 0.8 (± 0.7) and 0.09 (± 0.2) °C. This in vivo study showed the level of noise in PRFS-based thermometry introduced by respiratory motion in the context of MRgHIFU hyperthermia treatment for head and neck and the feasibility of reducing this noise using a multi-baseline technique.

The circumstellar environment of the B[e] star GG Car: an interferometric modeling

NASA Astrophysics Data System (ADS)

Domiciano de Souza, A.; Borges Fernandes, M.; Carciofi, A. C.; Chesneau, O.

2015-01-01

The research of stars with the B[e] phenomenon is still in its infancy, with several unanswered questions. Physically realistic models that treat the formation and evolution of their complex circumstellar environments are rare. The code HDUST (developed by A. C. Carciofi and J. Bjorkman) is one of the few existing codes that provides a self-consistent treatment of the radiative transfer in a gaseous and dusty circumstellar environment seen around B[e] supergiant stars. In this work we used the HDUST code to study the circumstellar medium of the binary system GG Car, where the primary component is probably an evolved B[e] supergiant. This system also presents a disk (probably circumbinary), which is responsible for the molecular and dusty signatures seen in GG Car spectra. We obtained VLTI/MIDI data on GG~Car at eight baselines, which allowed to spatially resolve the gaseous and dusty circumstellar environment. From the interferometric visibilities and SED modeling with HDUST, we confirm the presence of a compact ring, where the hot dust lies. We also show that large grains can reproduce the lack of structure in the SED and visibilities across the silicate band. We conclude the dust condensation site is much closer to the star than previously thought. This result provides stringent constraints on future theories of grain formation and growth around hot stars.

Very Large Telescope Interferometer observations of the dust geometry around R Coronae Borealis stars

NASA Astrophysics Data System (ADS)

Bright, S. N.; Chesneau, O.; Clayton, G. C.; De Marco, O.; Leão, I. C.; Nordhaus, J.; Gallagher, J. S.

2011-06-01

We are investigating the formation and evolution of dust around the hydrogen-deficient supergiants known as R Coronae Borealis (RCB) stars. We aim to determine the connection between the probable merger past of these stars and their current dust-production activities. We carried out high angular resolution interferometric observations of three RCB stars, namely RY Sgr, V CrA and V854 Cen, with the mid-infrared interferometer (MIDI) on the Very Large Telescope Interferometer (VLTI), using two telescope pairs. The baselines ranged from 30 to 60 m, allowing us to probe the dusty environment at very small spatial scales (˜50 mas or 400R★). The observations of the RCB star dust environments were interpreted using both geometrical models and one-dimensional radiative transfer codes. From our analysis, we find that asymmetric circumstellar material is apparent in RY Sgr, may also exist in V CrA and is possible for V854 Cen. Overall, we find that our observations are consistent with dust forming in clumps ejected randomly around the RCB star so that over time they create a spherically symmetric distribution of dust. However, we conclude that the determination of whether there is a preferred plane of dust ejection must wait until a time series of observations are obtained. Based on observations made with the Very Large Telescope Interferometer at Paranal Observatory under programme 079.D-0415.

DR Tauri: Temporal variability of the brightness distribution in the potential planet-forming region

NASA Astrophysics Data System (ADS)

Brunngräber, R.; Wolf, S.; Ratzka, Th.; Ober, F.

2016-01-01

Aims: We investigate the variability of the brightness distribution and the changing density structure of the protoplanetary disk around DR Tau, a classical T Tauri star. DR Tau is known for its peculiar variations from the ultraviolet (UV) to the mid-infrared (MIR). Our goal is to constrain the temporal variation of the disk structure based on photometric and MIR interferometric data. Methods: We observed DR Tau with the MID-infrared Interferometric instrument (MIDI) at the Very Large Telescope Interferometer (VLTI) at three epochs separated by about nine years, two months, respectively. We fit the spectral energy distribution and the MIR visibilities with radiative transfer simulations. Results: We are able to reproduce the spectral energy distribution as well as the MIR visibility for one of the three epochs (third epoch) with a basic disk model. We were able to reproduce the very different visibility curve obtained nine years earlier with a very similar baseline (first epoch), using the same disk model with a smaller scale height. The same density distribution also reproduces the observation made with a higher spatial resolution in the second epoch, I.e. only two months before the third epoch. Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere, Chile, under the programs 074.C-0342(A) and 092.C-0726(A,B).

Flexible, multi-measurement guided wave damage detection under varying temperatures

NASA Astrophysics Data System (ADS)

Douglass, Alexander C. S.; Harley, Joel B.

2018-04-01

Temperature compensation in structural health monitoring helps identify damage in a structure by removing data variations due to environmental conditions, such as temperature. Stretch-based methods are one of the most commonly used temperature compensation methods. To account for variations in temperature, stretch-based methods optimally stretch signals in time to optimally match a measurement to a baseline. All of the data is then compared with the single baseline to determine the presence of damage. Yet, for these methods to be effective, the measurement and the baseline must satisfy the inherent assumptions of the temperature compensation method. In many scenarios, these assumptions are wrong, the methods generate error, and damage detection fails. To improve damage detection, a multi-measurement damage detection method is introduced. By using each measurement in the dataset as a baseline, error caused by imperfect temperature compensation is reduced. The multi-measurement method increases the detection effectiveness of our damage metric, or damage indicator, over time and reduces the presence of additional peaks caused by temperature that could be mistaken for damage. By using many baselines, the variance of the damage indicator is reduced and the effects from damage are amplified. Notably, the multi-measurement improves damage detection over single-measurement methods. This is demonstrated through an increase in the maximum of our damage signature from 0.55 to 0.95 (where large values, up to a maximum of one, represent a statistically significant change in the data due to damage).

Surviving sepsis: a trust-wide approach. A multi-disciplinary team approach to implementing evidence-based guidelines.

PubMed

Gerber, Karin

2010-01-01

To share an experience of examining the true extent of the number of patients with severe sepsis being admitted, and the overall compliance with existing treatment guidelines in a district general hospital (DGH). Because of its aggressive, multi-factorial nature, sepsis is a rapid killer. Mortality associated with severe sepsis remains unacceptably high: 30-50%. When shock is present, mortality is reported to be even higher: 50-60%. The rapid diagnosis and management of sepsis is vital to successful treatment. The International Surviving Sepsis Campaign (SSC) was developed to help meet the challenges of sepsis and to improve its management, diagnosis and treatment. The overall aim is to reduce mortality from sepsis by 25% by 2009. Data on the number of patients admitted with severe sepsis to the DGH were previously unknown. The aim of the baseline audits was to determine the true extent of the problem and baseline mortality rates, resulting in an action plan to provide evidence-based care to patients with sepsis regardless of where in the hospital they were located. It was found that 11% of the patients audited presented with signs of severe sepsis and demonstrated elements of poor compliance with some elements of existing treatment guidelines as set out by the resuscitation component of the Surviving Sepsis Care Bundle. As an international campaign introduced predominantly within critical care, within this DGH the SSC teams' innovative approach has resulted in: * Better educated staff; * Objectives agreed within multi-disciplinary teams; * The appropriate assessment of resources; * Standardization of practice in terms of patients presenting with severe sepsis.

Childhood predictors of adolescent behaviour: The prospective association of familial factors with meeting physical activity guidelines.

PubMed

Brown, Helen Elizabeth; Corder, Kirsten; Atkin, Andrew J; van Sluijs, Esther M F

2017-06-01

Little is known about the longitudinal association of familial socio-demographic factors, behaviours, attitudes, or home environment with meeting physical activity guidelines. Our objective was to a) describe 4-year change in the prevalence of meeting guidelines, and characteristics of participants across categories of physical activity maintenance, and b) identify familial factors in childhood that are longitudinally associated with meeting guidelines in adolescence. Data on 17 parent- and child-reported family variables and objectively measured physical activity (ActiGraph GT1M) were available from 406 children (10.3 ± 0.3 years, 53.5% female) participating in the SPEEDY study. Average duration of week- and weekend day moderate-to-vigorous physical activity (MVPA, ≥ 2000 cpm) at baseline and follow-up (14.3 ± 0.3 years) were calculated to determine whether participants met 60 min MVPA/day guidelines at each assessment. Descriptives were calculated across four MVPA change categories. Multi-level logistic regression examined the association of baseline familial factors with meeting guidelines at follow-up, adjusting for sex, baseline physical activity, family socio-economic position, and school clustering. At follow-up, 51.5% and 36.1% of adolescents met guidelines on weekdays and weekend days, respectively (baseline: 68.0%, 67.2%). Girls were less likely than boys to remain sufficiently active, particularly on weekdays. Family social support was positively associated with adolescents meeting guidelines at weekends (OR 1.2; 95% CI 1.0-1.4). The presence of play equipment at home was negatively associated with meeting guidelines on weekdays (OR 0.5; 95% CI 0.3-0.8). Interventions that foster parent's facilitation of physical activity may help to encourage the upkeep of healthy behaviours during the transition from childhood to adolescence.

VLT interferometer upgrade for the 2nd generation of interferometric instruments

NASA Astrophysics Data System (ADS)

Gonté, Frederic; Woillez, Julien; Schuhler, Nicolas; Egner, Sebastian; Merand, Antoine; Abad, José Antonio; Abadie, Sergio; Abuter, Roberto; Acuña, Margarita; Allouche, Fatmé; Alonso, Jaime; Andolfalto, Luigi; Antonelli, Pierre; Avila, Gerardo; Barriga, Pablo José; Beltran, Juan; Berger, Jean-Philippe; Bolados, Carlos; Bonnet, Henri; Bourget, Pierre; Brast, Roland; Bristow, Paul; Caniguante, Luis; Castillo, Roberto; Conzelmann, Ralf; Cortes, Angela; Delplancke, Françoise; Del Valle, Diego; Derie, Frederic; Diaz, Alvaro; Donoso, Reinaldo; Dorn, Reinhold; Duhoux, Philippe; Dupuy, Christophe; Eisenhauer, Frank; Elao, Christian; Fuenteseca, Eloy; Fernandez, Ruben; Gaytan, Daniel; Glindemann, Andreas; Gonzales, Jaime; Guieu, Sylvain; Guisard, Stephane; Haguenauer, Pierre; Haimerl, Andreas; Heinz, Volker; Henriquez, Juan Pablo; van der Heyden, P.; Hubin, Norbert; Huerta, Rodrigo; Jochum, Lieselotte; Leiva, Alfredo; Lévêque, Samuel; Lizon, Jean-Louis; Luco, Fernando; Mardones, Pedro; Mellado, Angel; Osorio, Juan; Ott, Jürgen; Pallanca, Laurent; Pavez, Marcus; Pasquini, Luca; Percheron, Isabelle; Pirard, Jean-Francois; Than Phan, Duc; Pineda, Juan Carlos; Pino, Andres; Poupar, Sebastien; Ramírez, Andres; Reinero, Claudio; Riquelme, Miguel; Romero, Juan; Rivinius, Thomas; Rojas, Chester; Rozas, Felix; Salgado, Fernando; Scheithauer, Silvia; Schmid, Christian; Schöller, Markus; Siclari, Waldo; Stephan, Christian; Tamblay, Richard; Tapia, Mario; Tristram, Konrad; Valdes, Guillermo; de Wit, Willem-Jan; Wright, Andrew; Zins, Gerard

2016-08-01

ESO is undertaking a large upgrade of the infrastructure on Cerro Paranal in order to integrate the 2nd generation of interferometric instruments Gravity and MATISSE, and increase its performance. This upgrade started mid 2014 with the construction of a service station for the Auxiliary Telescopes and will end with the implementation of the adaptive optics system for the Auxiliary telescope (NAOMI) in 2018. This upgrade has an impact on the infrastructure of the VLTI, as well as its sub-systems and scientific instruments.

The Carbon Stars Adventure

NASA Astrophysics Data System (ADS)

Rau, Gioia; Paladini, C.; Hron, J.; Aringer, B.; Eriksson, K.; Groenewegen, M. A. T.; Nowotny, W.

We compare in a systematic way spectrometric, photometric and mid-infrared (VLTI/MIDI) interferometric measurements with different types of model atmospheres. Self-consistent dynamic model atmospheres in particular were used to interpret in a consistent way the dynamic behavior of gas and dust. The results underline how the joint use of different kind of observations, as photometry, spectroscopy and interferometry, is essential to understand the atmospheres of pulsating C-rich AGB stars. The sample of C-rich stars discussed in this work provides crucial constraints for the atmospheric structure.

Mirabegron improves quality-of-life, treatment satisfaction, and persistence in patients with overactive bladder: a multi-center, non-interventional, real-world, 12-month study.

PubMed

Freeman, Robert; Foley, Steve; Rosa Arias, José; Vicente, Eduardo; Grill, Robert; Kachlirova, Zuzana; Stari, Anny; Huang, Moses; Choudhury, Nurul

2018-05-01

Observational studies can provide evidence about patient outcomes in routine clinical practice. This prospective, non-interventional study (BELIEVE) is the largest real-world European study to date to assess quality-of-life, treatment satisfaction, resource utilization, and persistence in patients with overactive bladder (OAB) who were prescribed mirabegron as part of routine clinical practice. The primary objective was to evaluate change from baseline in quality-of-life based on overactive bladder questionnaire (OAB-q) sub-scales. Secondary objectives included evaluation of treatment persistence, patient satisfaction, healthcare resource utilization and adverse events (AEs). Follow-up was for 12 months with visit windows at 2-4 and 10-12 months. Median change from baseline in total OAB-q and its sub-scales (Health-related quality-of-life [HRQoL] and symptom bother scale) were assessed. Overall, 862 patients were enrolled from eight European countries. In the Full Analysis Set (FAS), 73.7% were female, mean age was 61.2 years; 47.7% ≥65 years. At baseline, 41.3% had switched from other OAB treatments, 42.2% were treatment naïve, 10.1% were lapsed, and 6.4% were on combination treatment. Symptom bother and HRQoL total scores improved from baseline to 2-4 and 10-12 months. There was a notable improvement in dry rate, increasing from 34.9% at baseline to 43.7% at 10-12 months in the FAS, and a reduction in pad use. Persistence was high, with 53.8% of FAS patients remaining on mirabegron at 10-12 months. Overall, no unexpected safety issues were observed and AEs were consistent with the known safety profile of mirabegron. Patients receiving mirabegron in a real-world setting reported meaningful improvements in QoL and health status, with a persistence rate of 53.8% at 12 months for the FAS. No unexpected safety issues were observed, and AEs were consistent with the known safety profile of mirabegron.

Using multi-objective robust decision making to support seasonal water management in the Chao Phraya River basin, Thailand

NASA Astrophysics Data System (ADS)

Riegels, Niels; Jessen, Oluf; Madsen, Henrik

2016-04-01

A multi-objective robust decision making approach is demonstrated that supports seasonal water management in the Chao Phraya River basin in Thailand. The approach uses multi-objective optimization to identify a Pareto-optimal set of management alternatives. Ensemble simulation is used to evaluate how each member of the Pareto set performs under a range of uncertain future conditions, and a robustness criterion is used to select a preferred alternative. Data mining tools are then used to identify ranges of uncertain factor values that lead to unacceptable performance for the preferred alternative. The approach is compared to a multi-criteria scenario analysis approach to estimate whether the introduction of additional complexity has the potential to improve decision making. Dry season irrigation in Thailand is managed through non-binding recommendations about the maximum extent of rice cultivation along with incentives for less water-intensive crops. Management authorities lack authority to prevent river withdrawals for irrigation when rice cultivation exceeds recommendations. In practice, this means that water must be provided to irrigate the actual planted area because of downstream municipal water supply requirements and water quality constraints. This results in dry season reservoir withdrawals that exceed planned withdrawals, reducing carryover storage to hedge against insufficient wet season runoff. The dry season planning problem in Thailand can therefore be framed in terms of decisions, objectives, constraints, and uncertainties. Decisions include recommendations about the maximum extent of rice cultivation and incentives for growing less water-intensive crops. Objectives are to maximize benefits to farmers, minimize the risk of inadequate carryover storage, and minimize incentives. Constraints include downstream municipal demands and water quality requirements. Uncertainties include the actual extent of rice cultivation, dry season precipitation, and precipitation in the following wet season. The multi-objective robust decision making approach is implemented as follows. First, three baseline simulation models are developed, including a crop water demand model, a river basin simulation model, and model of the impact of incentives on cropping patterns. The crop water demand model estimates irrigation water demands; the river basin simulation model estimates reservoir drawdown required to meet demands given forecasts of precipitation, evaporation, and runoff; the model of incentive impacts estimates the cost of incentives as function of marginal changes in rice yields. Optimization is used to find a set of non-dominated alternatives as a function of rice area and incentive decisions. An ensemble of uncertain model inputs is generated to represent uncertain hydrological and crop area forecasts. An ensemble of indicator values is then generated for each of the decision objectives: farmer benefits, end-of-wet-season reservoir storage, and the cost of incentives. A single alternative is selected from the Pareto set using a robustness criterion. Threshold values are defined for each of the objectives to identify ensemble members for which objective values are unacceptable, and the PRIM data mining algorithm is then used to identify input values associated with unacceptable model outcomes.

BIGHORN Computational Fluid Dynamics Theory, Methodology, and Code Verification & Validation Benchmark Problems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xia, Yidong; Andrs, David; Martineau, Richard Charles

This document presents the theoretical background for a hybrid finite-element / finite-volume fluid flow solver, namely BIGHORN, based on the Multiphysics Object Oriented Simulation Environment (MOOSE) computational framework developed at the Idaho National Laboratory (INL). An overview of the numerical methods used in BIGHORN are discussed and followed by a presentation of the formulation details. The document begins with the governing equations for the compressible fluid flow, with an outline of the requisite constitutive relations. A second-order finite volume method used for solving the compressible fluid flow problems is presented next. A Pressure-Corrected Implicit Continuous-fluid Eulerian (PCICE) formulation for timemore » integration is also presented. The multi-fluid formulation is being developed. Although multi-fluid is not fully-developed, BIGHORN has been designed to handle multi-fluid problems. Due to the flexibility in the underlying MOOSE framework, BIGHORN is quite extensible, and can accommodate both multi-species and multi-phase formulations. This document also presents a suite of verification & validation benchmark test problems for BIGHORN. The intent for this suite of problems is to provide baseline comparison data that demonstrates the performance of the BIGHORN solution methods on problems that vary in complexity from laminar to turbulent flows. Wherever possible, some form of solution verification has been attempted to identify sensitivities in the solution methods, and suggest best practices when using BIGHORN.« less

Sensitivity of Magnetospheric Multi-Scale (MMS) Mission Navigation Accuracy to Major Error Sources

NASA Technical Reports Server (NTRS)

Olson, Corwin; Long, Anne; Car[emter. Russell

2011-01-01

The Magnetospheric Multiscale (MMS) mission consists of four satellites flying in formation in highly elliptical orbits about the Earth, with a primary objective of studying magnetic reconnection. The baseline navigation concept is independent estimation of each spacecraft state using GPS pseudorange measurements referenced to an Ultra Stable Oscillator (USO) with accelerometer measurements included during maneuvers. MMS state estimation is performed onboard each spacecraft using the Goddard Enhanced Onboard Navigation System (GEONS), which is embedded in the Navigator GPS receiver. This paper describes the sensitivity of MMS navigation performance to two major error sources: USO clock errors and thrust acceleration knowledge errors.

Sensitivity of Magnetospheric Multi-Scale (MMS) Mission Naviation Accuracy to Major Error Sources

NASA Technical Reports Server (NTRS)

Olson, Corwin; Long, Anne; Carpenter, J. Russell

2011-01-01

The Magnetospheric Multiscale (MMS) mission consists of four satellites flying in formation in highly elliptical orbits about the Earth, with a primary objective of studying magnetic reconnection. The baseline navigation concept is independent estimation of each spacecraft state using GPS pseudorange measurements referenced to an Ultra Stable Oscillator (USO) with accelerometer measurements included during maneuvers. MMS state estimation is performed onboard each spacecraft using the Goddard Enhanced Onboard Navigation System (GEONS), which is embedded in the Navigator GPS receiver. This paper describes the sensitivity of MMS navigation performance to two major error sources: USO clock errors and thrust acceleration knowledge errors.

Family, Community and Clinic Collaboration to Treat Overweight and Obese Children: Stanford GOALS -- a Randomized Controlled Trial of a Three-Year, Multi-Component, Multi-Level, Multi-Setting Intervention

PubMed Central

Robinson, Thomas N.; Matheson, Donna; Desai, Manisha; Wilson, Darrell M.; Weintraub, Dana L.; Haskell, William L.; McClain, Arianna; McClure, Samuel; Banda, Jorge; Sanders, Lee M.; Haydel, K. Farish; Killen, Joel D.

2013-01-01

Objective To test the effects of a three-year, community-based, multi-component, multi-level, multi-setting (MMM) approach for treating overweight and obese children. Design Two-arm, parallel group, randomized controlled trial with measures at baseline, 12, 24, and 36 months after randomization. Participants Seven through eleven year old, overweight and obese children (BMI ≥ 85th percentile) and their parents/caregivers recruited from community locations in low-income, primarily Latino neighborhoods in Northern California. Interventions Families are randomized to the MMM intervention versus a community health education active-placebo comparison intervention. Interventions last for three years for each participant. The MMM intervention includes a community-based after school team sports program designed specifically for overweight and obese children, a home-based family intervention to reduce screen time, alter the home food/eating environment, and promote self-regulatory skills for eating and activity behavior change, and a primary care behavioral counseling intervention linked to the community and home interventions. The active-placebo comparison intervention includes semi-annual health education home visits, monthly health education newsletters for children and for parents/guardians, and a series of community-based health education events for families. Main Outcome Measure Body mass index trajectory over the three-year study. Secondary outcome measures include waist circumference, triceps skinfold thickness, accelerometer-measured physical activity, 24-hour dietary recalls, screen time and other sedentary behaviors, blood pressure, fasting lipids, glucose, insulin, hemoglobin A1c, C-reactive protein, alanine aminotransferase, and psychosocial measures. Conclusions The Stanford GOALS trial is testing the efficacy of a novel community-based multi-component, multi-level, multi-setting treatment for childhood overweight and obesity in low-income, Latino families. PMID:24028942

Observational constraints for the circumstellar disk of the B[e] star CPD-52 9243

NASA Astrophysics Data System (ADS)

Cidale, L. S.; Borges Fernandes, M.; Andruchow, I.; Arias, M. L.; Kraus, M.; Chesneau, O.; Kanaan, S.; Curé, M.; de Wit, W. J.; Muratore, M. F.

2012-12-01

Context. The formation and evolution of gas and dust environments around B[e] supergiants are still open issues. Aims: We intend to study the geometry, kinematics and physical structure of the circumstellar environment (CE) of the B[e] supergiant CPD-52 9243 to provide further insights into the underlying mechanism causing the B[e] phenomenon. Methods: The influence of the different physical mechanisms acting on the CE (radiation pressure, rotation, bi-stability or tidal forces) is somehow reflected in the shape and kinematic properties of the gas and dust regions (flaring, Keplerian, accretion or outflowing disks). To investigate these processes we mainly used quasi-simultaneous observations taken with high spatial resolution optical long-baseline interferometry (VLTI/MIDI), near-IR spectroscopy of CO bandhead features (Gemini/Phoenix and VLT/CRIRES) and optical spectra (CASLEO/REOSC). Results: High angular resolution interferometric measurements obtained with VLTI/MIDI provide strong support for the presence of a dusty disk(ring)-like structure around CPD-52 9243, with an upper limit for its inner edge of ~8 mas (~27.5 AU, considering a distance of 3.44 kpc to the star). The disk has an inclination angle with respect to the line of sight of 46 ± 7°. The study of CO first overtone bandhead evidences a disk structure in Keplerian rotation. The optical spectrum indicates a rapid outflow in the polar direction. Conclusions: The IR emission (CO and warm dust) indicates Keplerian rotation in a circumstellar disk while the optical line transitions of various species are consistent with a polar wind. Both structures appear simultaneously and provide further evidence for the proposed paradigms of the mass-loss in supergiant B[e] stars. The presence of a detached cold CO ring around CPD-52 9243 could be due to a truncation of the inner disk caused by a companion, located possibly interior to the disk rim, clearing the center of the system. More spectroscopic and interferometric data are necessary to determine a possible binary nature of the star. Based on observations taken with: 1) Telescopes at Paranal ESO Observatory under the program 085.D-0454 and 385.D-0513A; 2) Gemini South/Phoenix instrument, science program GS-2010A-Q-41; 3) J. Sahade Telescope at Complejo Astronómico El Leoncito (CASLEO), operated under an agreement between the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina, the Secretaría de Ciencia y Tecnología de la Nación and the National Universities of La Plata, Córdoba and San Juan.

Is the Critical Rotation of Be Stars Really Critical for the Be Phenomenon?

NASA Astrophysics Data System (ADS)

Stee, Ph.; Meilland, A.

We aim to study the effect of the fast rotation, stellar wind and circumstellar disks around active hot stars and their effects on the formation and evolution of these massive stars. For that purpose, we obtained, for the first time, interferometric measurements of three active hot stars, namely α Arae, κ CMa and Achernar, using the VLTI /AMBER and VLTI/MIDI instruments which allow us to study the kinematics of the central star and its surrounding circumstellar matter. These data coupled with our numerical code SIMECA (SIMulation pour Etoiles Chaudes Actives) seem to indicate that the presence of equatorial disks and polar stellar wind around Be stars are not correlated. A polar stellar wind was detected for α Arae and Achernar whereas κ CMa seems to exhibit no stellar wind. On the other hand, these two first Be stars are certainly nearly critical rotators whereas the last one seems to be far from the critical rotation. Thus a polar stellar wind may be due to the nearly critical rotation which induces a local effective temperature change following the von Zeipel theorem, producing a hotter polar region triggering a polar stellar wind. This critical rotation may also explain the formation of a circumstellar disk which is formed by the centrifugal force balancing the equatorial effective gravity of the central star. Following these results we try to investigate if critical rotation may be the clue for the Be phenomenon.

Lack of Association of Oral Calcium Supplementation with Coronary Artery Calcification in Rheumatoid Arthritis

PubMed Central

Giles, Jon T.; Bathon, Joan M.

2015-01-01

Objectives To investigate the association between oral calcium supplementation and coronary arterial calcification among rheumatoid arthritis (RA) patients without known cardiovascular disease (CVD). Methods This study was nested in a prospective cohort study of RA patients without known CVD. Daily supplemental calcium dose was ascertained from prescription and over-the-counter medications at baseline and visit 2 (median 20 months post-baseline). Coronary artery calcium (CAC), a measure of coronary atherosclerosis, was assessed by cardiac multi-detector row computed tomography at baseline and visit 3 (median 39 months post-baseline). The association of calcium supplementation with CAC was explored. Results Among the 145 RA patients studied, 42 (28%) took ≥1000mg/day of supplemental calcium at baseline. Forty-four (30%) and 50 (34%) had a CAC score >100 units at baseline and follow-up, respectively. Baseline CAC scores >100 units were significantly less frequent in the higher (≥1000mg/day) supplemental calcium group than in the lower dosed group (<1000mg/day) [OR 0.28 (95% CI 0.11-0.74)]; this remained significant after adjusting for relevant confounders [OR 0.30 (95% CI 0.09-0.93)]. Similarly, at the third study visit, CAC scores >100 units were less frequent in the higher vs. the lower supplemental calcium group [OR 0.41 (95% CI 0.18-0.95)]. When adjusted for relevant confounders, statistical significance was lost [OR 0.39 (95% CI 0.14-1.12)]. No gender interaction and no change in CAC score over time were appreciated. Conclusion Higher levels of oral calcium supplementation were not associated with an increased risk of coronary atherosclerosis as measured by CAC score in this RA cohort. PMID:25808397

THE SLOAN DIGITAL SKY SURVEY REVERBERATION MAPPING PROJECT: TECHNICAL OVERVIEW

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shen, Yue; Brandt, W. N.; Dawson, Kyle S.

2015-01-01

The Sloan Digital Sky Survey Reverberation Mapping (SDSS-RM) project is a dedicated multi-object RM experiment that has spectroscopically monitored a sample of 849 broad-line quasars in a single 7 deg{sup 2} field with the SDSS-III Baryon Oscillation Spectroscopic Survey spectrograph. The RM quasar sample is flux-limited to i {sub psf} = 21.7 mag, and covers a redshift range of 0.1 < z < 4.5 without any other cuts on quasar properties. Optical spectroscopy was performed during 2014 January-July dark/gray time, with an average cadence of ∼4 days, totaling more than 30 epochs. Supporting photometric monitoring in the g and i bandsmore » was conducted at multiple facilities including the Canada-France-Hawaii Telescope (CFHT) and the Steward Observatory Bok telescope in 2014, with a cadence of ∼2 days and covering all lunar phases. The RM field (R.A., decl. = 14:14:49.00, +53:05:00.0) lies within the CFHT-LS W3 field, and coincides with the Pan-STARRS 1 (PS1) Medium Deep Field MD07, with three prior years of multi-band PS1 light curves. The SDSS-RM six month baseline program aims to detect time lags between the quasar continuum and broad line region (BLR) variability on timescales of up to several months (in the observed frame) for ∼10% of the sample, and to anchor the time baseline for continued monitoring in the future to detect lags on longer timescales and at higher redshift. SDSS-RM is the first major program to systematically explore the potential of RM for broad-line quasars at z > 0.3, and will investigate the prospects of RM with all major broad lines covered in optical spectroscopy. SDSS-RM will provide guidance on future multi-object RM campaigns on larger scales, and is aiming to deliver more than tens of BLR lag detections for a homogeneous sample of quasars. We describe the motivation, design, and implementation of this program, and outline the science impact expected from the resulting data for RM and general quasar science.« less

A disc inside the bipolar planetary nebula M2-9

NASA Astrophysics Data System (ADS)

Lykou, F.; Chesneau, O.; Zijlstra, A. A.; Castro-Carrizo, A.; Lagadec, E.; Balick, B.; Smith, N.

2011-03-01

Aims: Bipolarity in proto-planetary and planetary nebulae is associated with events occurring in or around their cores. Past infrared observations have revealed the presence of dusty structures around the cores, many in the form of discs. Characterising those dusty discs provides invaluable constraints on the physical processes that govern the final mass expulsion of intermediate mass stars. We focus this study on the famous M2-9 bipolar nebula, where the moving lighthouse beam pattern indicates the presence of a wide binary. The compact and dense dusty core in the centre of the nebula can be studied by means of optical interferometry. Methods: M2-9 was observed with VLTI/MIDI at 39-47 m baselines with the UT2-UT3 and UT3-UT4 baseline configurations. These observations are interpreted using a dust radiative transfer Monte Carlo code. Results: A disc-like structure is detected perpendicular to the lobes, and a good fit is found with a stratified disc model composed of amorphous silicates. The disc is compact, 25 × 35 mas at 8 μm and 37 × 46 mas at 13 μm. For the adopted distance of 1.2 kpc, the inner rim of the disc is ~15 AU. The mass represents a few percent of the mass found in the lobes. The compactness of the disc puts strong constraints on the binary content of the system, given an estimated orbital period 90-120 yr. We derive masses of the binary components between 0.6-1.0 M⊙ for a white dwarf and 0.6-1.4 M⊙ for an evolved star. We present different scenarios on the geometric structure of the disc accounting for the interactions of the binary system, which includes an accretion disc as well. Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere, Chile, ESO N: 079.D-146.

Age at Menopause and Incident Heart Failure: The Multi-Ethnic Study of Atherosclerosis

PubMed Central

Ebong, Imo A.; Watson, Karol E.; Goff, David C.; Bluemke, David A.; Srikanthan, Preethi; Horwich, Tamara; Bertoni, Alain G.

2014-01-01

Objective To evaluate associations of early menopause (menopause occurring before 45 years of age) and age at menopause with incident heart failure (HF) in post-menopausal women. We also explored associations of early, and age at menopause with left ventricular (LV) measures of structure and function in post-menopausal women. Methods We included 2947 post-menopausal women, aged 45-84 years, without known cardiovascular disease (2000-2002), from the Multi-Ethnic study of Atherosclerosis. Cox-Proportional hazards models were used to examine associations of early, and age at menopause with incident HF. In 2123 post-menopausal women in whom cardiac magnetic resonance imaging was obtained at baseline, we explored associations of early, and age at menopause with LV measures using multivariable linear regression. Results Over a median follow-up of 8.5 years, we observed 71 HF events. There were no significant interactions with ethnicity for incident HF (Pinteraction>0.05). In adjusted analysis, early menopause was associated with increased risk of incident HF [1.66 (1.01-2.73)], while each year increase in age at menopause was associated with decreased risk of incident HF [0.96 (0.94-0.99)]. We observed significant interactions between early menopause and ethnicity for LV mass to volume ratio (LVMVR), Pinteraction=0.02. In Chinese-American women, early menopause was associated with higher LVMVR (+0.11, p=0.0002), while each year increase in age at menopause was associated with lower LVMVR (−0.004, p=0.04) at baseline. Conclusion An older menopausal age is independently associated with decreased risk of incident HF. Concentric LV remodelling, indicated by a higher LVMVR was present in Chinese-American women with early menopause at baseline. PMID:24423934

Serum Phosphate is Associated with Aortic Valve Calcification in the Multi-Ethnic Study of Atherosclerosis (MESA)

PubMed Central

Linefsky, Jason P.; O’Brien, Kevin D.; Sachs, Michael; Katz, Ronit; Eng, John; Michos, Erin D.; Budoff, Matthew J.; de Boer, Ian; Kestenbaum, Bryan

2014-01-01

Objectives This study sought to investigate associations of phosphate metabolism biomarkers with aortic valve calcification (AVC). Background Calcific aortic valve disease (CAVD) is a common progressive condition that involves inflammatory and calcification mediators. Currently there are no effective medical treatments, but mineral metabolism pathways may be important in the development and progression of disease. Methods We examined associations of phosphate metabolism biomarkers, including serum phosphate, urine phosphate, parathyroid hormone (PTH) and serum fibroblast growth factor (FGF)-23, with CT-assessed AVC at study baseline and in short-term follow-up in 6,814 participants of the Multi-Ethnic Study of Atherosclerosis (MESA). Results At baseline, AVC prevalence was 13.2%. Higher serum phosphate levels were associated with significantly greater AVC prevalence (relative risk 1.3 per 1mg/dL increment, 95% confidence incidence: 1.1 to 1.5, p < 0.001). Serum FGF-23, serum PTH, and urine phosphate were not associated with prevalent AVC. Average follow-up CT evaluation was 2.4 years (range 0.9–4.9 years) with an AVC incidence of 4.1%. Overall, phosphate metabolism biomarkers were not associated with incident AVC except in the top FGF-23 quartile. Conclusions Serum phosphate levels are significantly associated with AVC prevalence. Further study of phosphate metabolism as a modifiable risk factor for AVC is warranted. PMID:24530958

Research a Novel Integrated and Dynamic Multi-object Trade-Off Mechanism in Software Project

NASA Astrophysics Data System (ADS)

Jiang, Weijin; Xu, Yuhui

Aiming at practical requirements of present software project management and control, the paper presented to construct integrated multi-object trade-off model based on software project process management, so as to actualize integrated and dynamic trade-oil of the multi-object system of project. Based on analyzing basic principle of dynamic controlling and integrated multi-object trade-off system process, the paper integrated method of cybernetics and network technology, through monitoring on some critical reference points according to the control objects, emphatically discussed the integrated and dynamic multi- object trade-off model and corresponding rules and mechanism in order to realize integration of process management and trade-off of multi-object system.

Early Menopause Predicts Future Coronary Heart Disease and Stroke: The Multi-Ethnic Study of Atherosclerosis (MESA)

PubMed Central

Wellons, Melissa; Ouyang, Pamela; Schreiner, Pamela J; Herrington, David M; Vaidya, Dhananjay

2012-01-01

Objective Cardiovascular disease is the number one killer of women. Identifying women at risk of cardiovascular disease has tremendous public health importance. Early menopause is associated with increased cardiovascular disease events in some predominantly white populations, but not consistently. Our objective was to determine if a self-reported early menopause (menopause at an age <46) identifies women as at risk for future coronary heart disease or stroke. Methods The study population came from the Multi-Ethnic Study of Atherosclerosis, a longitudinal, ethnically diverse cohort study of US men and women aged 45 to 84 years enrolled in 2000–2002 and followed up until 2008. The association between a personal history of early menopause (either natural menopause or surgical removal of ovaries at an age <46) and future coronary heart disease and stroke was assessed in 2509 women (ages 45–84, 987 White, 331 Chinese, 641 Black, 550 Hispanic) from the Multi-Ethnic Study Atherosclerosis, who were free of cardiovascular disease at baseline. Results 693/2509 (28%) of women reported either surgical or natural early menopause. In survival curves, women with early menopause had worse coronary heart disease and stroke-free survival (log rank p=<0.008 and 0.0158). In models adjusted for age, race/ethnicity, Multi-Ethnic Study Atherosclerosis site and traditional cardiovascular disease risk factors, this risk for coronary heart disease and stroke remained (HR 2.08, 95% CI 1.17, 3.70 and 2.19, 95% CI 1.11, 4.32, respectively). Conclusions Early menopause is positively associated with coronary heart disease and stroke in a multiethnic cohort, independent of traditional cardiovascular disease risk factors. PMID:22692332

Single Versus Multi-visit Endodontic Treatment of Teeth with Apical Periodontitis: An in vivo Study with 1-year Evaluation

PubMed Central

Gill, GS; Bhuyan, AC; Kalita, C; Das, L; Kataki, R; Bhuyan, D

2016-01-01

Background: Apical periodontitis (AP) is one of the most prevalent diseases of the teeth. Treatment of AP is based on the removal of the cause, i.e., bacteria from the root canals. Achievement of adequate bacterial eradication in one appointment treatment remains a controversy. Aim: This prospective study was conducted with the objective to compare the periapical healing of teeth with AP treated in (a) single visit versus (b) two visits, either with or without Vitapex as an intracanal medicament. Subjects and Methods: Patients were selected randomly from the Department of Conservative Dentistry and Endodontics. Forty-three patients (81 teeth) met the inclusion criteria, i.e., AP (both symptomatic and asymptomatic) visible radiographically size ≥2 mm × 2 mm, not suffering from any immune-compromising disease, age between 16 and 65 years and tooth not accessed previously. Patients were randomly divided into three groups, i.e., single-visit group (Group 1), multi-visit group without any intracanal medicament (Group 2), and multi-visit group with Vitapex as interim intracanal medicament (Group 3). Comparison was done radiographically using periapical index (PAI). The primary outcome measure was the change in periapical radiolucency after 1 year assessed by PAI scores. The Mann-Whitney U-test was used to evaluate differences between groups at baseline (immediate postoperative) and at the 12-month follow-up evaluation. Change in PAI score for each group from baseline to 12-month follow-up evaluation was tested with the Wilcoxon signed rank test. The secondary outcome measures, proportion of teeth in each group that could be considered improved (decreased PAI score) or healed (PAI <2), were assessed with the Chi-square test. Results: No statistically significant difference in periapical healing was found between three groups. Conclusion: After 1-year evaluation, no difference in periapical healing was found between single-visit treatment and multi-visit treatment groups with the given sample size. PMID:27144072

Single Versus Multi-visit Endodontic Treatment of Teeth with Apical Periodontitis: An in vivo Study with 1-year Evaluation.

PubMed

Gill, G S; Bhuyan, A C; Kalita, C; Das, L; Kataki, R; Bhuyan, D

2016-01-01

Apical periodontitis (AP) is one of the most prevalent diseases of the teeth. Treatment of AP is based on the removal of the cause, i.e., bacteria from the root canals. Achievement of adequate bacterial eradication in one appointment treatment remains a controversy. This prospective study was conducted with the objective to compare the periapical healing of teeth with AP treated in (a) single visit versus (b) two visits, either with or without Vitapex as an intracanal medicament. Patients were selected randomly from the Department of Conservative Dentistry and Endodontics. Forty-three patients (81 teeth) met the inclusion criteria, i.e., AP (both symptomatic and asymptomatic) visible radiographically size ≥2 mm × 2 mm, not suffering from any immune-compromising disease, age between 16 and 65 years and tooth not accessed previously. Patients were randomly divided into three groups, i.e., single-visit group (Group 1), multi-visit group without any intracanal medicament (Group 2), and multi-visit group with Vitapex as interim intracanal medicament (Group 3). Comparison was done radiographically using periapical index (PAI). The primary outcome measure was the change in periapical radiolucency after 1 year assessed by PAI scores. The Mann-Whitney U-test was used to evaluate differences between groups at baseline (immediate postoperative) and at the 12-month follow-up evaluation. Change in PAI score for each group from baseline to 12-month follow-up evaluation was tested with the Wilcoxon signed rank test. The secondary outcome measures, proportion of teeth in each group that could be considered improved (decreased PAI score) or healed (PAI <2), were assessed with the Chi-square test. No statistically significant difference in periapical healing was found between three groups. After 1-year evaluation, no difference in periapical healing was found between single-visit treatment and multi-visit treatment groups with the given sample size.

An improved robust buffer allocation method for the project scheduling problem

NASA Astrophysics Data System (ADS)

Ghoddousi, Parviz; Ansari, Ramin; Makui, Ahmad

2017-04-01

Unpredictable uncertainties cause delays and additional costs for projects. Often, when using traditional approaches, the optimizing procedure of the baseline project plan fails and leads to delays. In this study, a two-stage multi-objective buffer allocation approach is applied for robust project scheduling. In the first stage, some decisions are made on buffer sizes and allocation to the project activities. A set of Pareto-optimal robust schedules is designed using the meta-heuristic non-dominated sorting genetic algorithm (NSGA-II) based on the decisions made in the buffer allocation step. In the second stage, the Pareto solutions are evaluated in terms of the deviation from the initial start time and due dates. The proposed approach was implemented on a real dam construction project. The outcomes indicated that the obtained buffered schedule reduces the cost of disruptions by 17.7% compared with the baseline plan, with an increase of about 0.3% in the project completion time.

A "Sit Less, Walk More" Workplace Intervention for Office Workers: Long-Term Efficacy of a Quasi-Experimental Study.

PubMed

Lin, Yun-Ping; Hong, OiSaeng; Lin, Chiu-Chu; Lu, Shu-Hua; Chen, Meei-Maan; Lee, Kwo-Chen

2018-06-01

This study tested the maintenance outcomes of a 3-month Sit Less, Walk More (SLWM) workplace intervention for office workers compared with usual care at 12 months from the baseline. A quasi-experimental study was conducted in two workplaces. The intervention group (n = 51) received multi-component intervention and the comparison group (n = 50) received newsletters only. The outcomes of the study (self-reported psychosocial, physical activity, sitting, and lost productivity; objectively measured cardiometabolic biomarkers) were compared at baseline, 3, and 12 months. Generalized estimating equations analyses found that the intervention group had significant improvements in self-regulation for sitting less and moving more (P = 0.017), walking (P = 0.003), weight (P = 0.013), waist circumference (P = 0.002), and insulin (P = 0.000) at 12 months compared with the comparison group. The SLWM intervention was effective in improving self-regulation, walking, and some cardiometabolic biomarkers in office workers.

Optimization of multi-objective micro-grid based on improved particle swarm optimization algorithm

NASA Astrophysics Data System (ADS)

Zhang, Jian; Gan, Yang

2018-04-01

The paper presents a multi-objective optimal configuration model for independent micro-grid with the aim of economy and environmental protection. The Pareto solution set can be obtained by solving the multi-objective optimization configuration model of micro-grid with the improved particle swarm algorithm. The feasibility of the improved particle swarm optimization algorithm for multi-objective model is verified, which provides an important reference for multi-objective optimization of independent micro-grid.

The natural history of children with joint hypermobility syndrome and Ehlers-Danlos hypermobility type: a longitudinal cohort study.

PubMed

Scheper, Mark C; Nicholson, Lesley L; Adams, Roger D; Tofts, Louise; Pacey, Verity

2017-12-01

The objective of the manuscript was to describe the natural history of complaints and disability in children diagnosed with joint hypermobility syndrome (JHS)/Ehlers-Danlos-hypermobility type (EDS-HT) and to identify the constructs that underlie functional decline. One hundred and one JHS/EDS-HT children were observed over 3 years and assessed at three time points on the following: functional impairments, quality of life, connective tissue laxity, muscle function, postural control and musculoskeletal and multi-systemic complaints. Cluster analysis was performed to identify subgroups in severity. Clinical profiles were determined for these subgroups, and differences were assessed by multivariate analysis of covariance. Mixed linear regression models were used to determine the subsequent trajectories. Finally, an exploratory factor analysis was used to uncover the underlying constructs of functional impairment. Three clusters of children were identified in terms of functional impairment: mild, moderately and severely affected. Functional impairment at baseline was predictive of worsening trajectories in terms of reduced walking distance and decreased quality of life (P ⩽ 0.05) over 3 years. Multiple interactions between the secondary outcomes were observed, with four underlying constructs identified. All four constructs (multi-systemic effects, pain, fatigue and loss of postural control) contributed significantly to disability (P ⩽ 0.046). Children diagnosed with JHS/EDS-HT who have a high incidence of multi-systemic complaints (particularly, orthostatic intolerance, urinary incontinence and diarrhoea) and poor postural control in addition to high levels of pain and fatigue at baseline are most likely to have a deteriorating trajectory of functional impairment and, accordingly, warrant clinical prioritization. © The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com

Resting Heart Rate as Predictor for Left Ventricular Dysfunction and Heart Failure: The Multi-Ethnic Study of Atherosclerosis

PubMed Central

Opdahl, Anders; Venkatesh, Bharath Ambale; Fernandes, Veronica R. S.; Wu, Colin O.; Nasir, Khurram; Choi, Eui-Young; Almeida, Andre L. C.; Rosen, Boaz; Carvalho, Benilton; Edvardsen, Thor; Bluemke, David A.; Lima, Joao A. C.

2014-01-01

OBJECTIVE To investigate the relationship between baseline resting heart rate and incidence of heart failure (HF) and global and regional left ventricular (LV) dysfunction. BACKGROUND The association of resting heart rate to HF and LV function is not well described in an asymptomatic multi-ethnic population. METHODS Participants in the Multi-Ethnic Study of Atherosclerosis had resting heart rate measured at inclusion. Incident HF was registered (n=176) during follow-up (median 7 years) in those who underwent cardiac MRI (n=5000). Changes in ejection fraction (ΔEF) and peak circumferential strain (Δεcc) were measured as markers of developing global and regional LV dysfunction in 1056 participants imaged at baseline and 5 years later. Time to HF (Cox model) and Δεcc and ΔEF (multiple linear regression models) were adjusted for demographics, traditional cardiovascular risk factors, calcium score, LV end-diastolic volume and mass in addition to resting heart rate. RESULTS Cox analysis demonstrated that for 1 bpm increase in resting heart rate there was a 4% greater adjusted relative risk for incident HF (Hazard Ratio: 1.04 (1.02, 1.06 (95% CI); P<0.001). Adjusted multiple regression models demonstrated that resting heart rate was positively associated with deteriorating εcc and decrease in EF, even in analyses when all coronary heart disease events were excluded from the model. CONCLUSION Elevated resting heart rate is associated with increased risk for incident HF in asymptomatic participants in MESA. Higher heart rate is related to development of regional and global LV dysfunction independent of subclinical atherosclerosis and coronary heart disease. PMID:24412444

A multi-scale ensemble-based framework for forecasting compound coastal-riverine flooding: The Hackensack-Passaic watershed and Newark Bay

NASA Astrophysics Data System (ADS)

Saleh, F.; Ramaswamy, V.; Wang, Y.; Georgas, N.; Blumberg, A.; Pullen, J.

2017-12-01

Estuarine regions can experience compound impacts from coastal storm surge and riverine flooding. The challenges in forecasting flooding in such areas are multi-faceted due to uncertainties associated with meteorological drivers and interactions between hydrological and coastal processes. The objective of this work is to evaluate how uncertainties from meteorological predictions propagate through an ensemble-based flood prediction framework and translate into uncertainties in simulated inundation extents. A multi-scale framework, consisting of hydrologic, coastal and hydrodynamic models, was used to simulate two extreme flood events at the confluence of the Passaic and Hackensack rivers and Newark Bay. The events were Hurricane Irene (2011), a combination of inland flooding and coastal storm surge, and Hurricane Sandy (2012) where coastal storm surge was the dominant component. The hydrodynamic component of the framework was first forced with measured streamflow and ocean water level data to establish baseline inundation extents with the best available forcing data. The coastal and hydrologic models were then forced with meteorological predictions from 21 ensemble members of the Global Ensemble Forecast System (GEFS) to retrospectively represent potential future conditions up to 96 hours prior to the events. Inundation extents produced by the hydrodynamic model, forced with the 95th percentile of the ensemble-based coastal and hydrologic boundary conditions, were in good agreement with baseline conditions for both events. The USGS reanalysis of Hurricane Sandy inundation extents was encapsulated between the 50th and 95th percentile of the forecasted inundation extents, and that of Hurricane Irene was similar but with caveats associated with data availability and reliability. This work highlights the importance of accounting for meteorological uncertainty to represent a range of possible future inundation extents at high resolution (∼m).

Two antenna, two pass interferometric synthetic aperture radar

DOEpatents

Martinez, Ana; Doerry, Armin W.; Bickel, Douglas L.

2005-06-28

A multi-antenna, multi-pass IFSAR mode utilizing data driven alignment of multiple independent passes can combine the scaling accuracy of a two-antenna, one-pass IFSAR mode with the height-noise performance of a one-antenna, two-pass IFSAR mode. A two-antenna, two-pass IFSAR mode can accurately estimate the larger antenna baseline from the data itself and reduce height-noise, allowing for more accurate information about target ground position locations and heights. The two-antenna, two-pass IFSAR mode can use coarser IFSAR data to estimate the larger antenna baseline. Multi-pass IFSAR can be extended to more than two (2) passes, thereby allowing true three-dimensional radar imaging from stand-off aircraft and satellite platforms.

Daily multi-micronutrient supplementation during tuberculosis treatment increases weight and grip strength among HIV-uninfected but not HIV-infected patients in Mwanza, Tanzania.

PubMed

PrayGod, George; Range, Nyagosya; Faurholt-Jepsen, Daniel; Jeremiah, Kidola; Faurholt-Jepsen, Maria; Aabye, Martine G; Jensen, Lotte; Jensen, Andreas V; Grewal, Harleen M S; Magnussen, Pascal; Changalucha, John; Andersen, Aase Bengaard; Friis, Henrik

2011-04-01

Undernutrition is common among tuberculosis (TB) patients. The objective of this study was to assess the effect of multi-micronutrient supplementation during TB treatment on weight, body composition, and handgrip strength. A total of 865 patients with smear-positive (PTB+) or -negative (PTB-) pulmonary TB were randomly allocated to receive a daily biscuit with or without multi-micronutrients for 60 d during the intensive phase of TB treatment. Weight, arm fat area, arm muscle area, and handgrip strength were assessed at baseline and after 2 and 5 mo. At 2 mo, the multi-micronutrient supplementation led to a higher handgrip gain (1.22 kg; 95% CI = 0.50, 1.94; P = 0.001) but had no effects on other outcomes. The effects of multi-micronutrient supplementation were modified by HIV infection (P-interaction = 0.002). Among HIV- patients, multi-micronutrient supplementation increased weight gain by 590 g (95% CI = -40, 1210; P = 0.07) and handgrip strength by 1.6 kg (95% CI = 0.78, 2.47; P < 0.001), whereas among HIV+ patients, it reduced weight gain by 1440 g (95% CI = 290, 2590; P = 0.002) and had no effect on handgrip strength (0.07 kg; 95% CI = -1.30, 1.46; P = 0.91). The reduced weight gain among HIV+ patients receiving multi-micronutrient supplementation seemed to be explained by a higher proportion of patients reporting fever. At 5 mo, the effects on weight were sustained, whereas there was no effect on handgrip strength. In conclusion, multi-micronutrient supplementation given as a biscuit is beneficial among HIV- PTB patients and may be recommended to TB programs. More research is needed to develop an effective supplement for HIV+ PTB patients.

Tomographic Imaging of a Forested Area By Airborne Multi-Baseline P-Band SAR.

PubMed

Frey, Othmar; Morsdorf, Felix; Meier, Erich

2008-09-24

In recent years, various attempts have been undertaken to obtain information about the structure of forested areas from multi-baseline synthetic aperture radar data. Tomographic processing of such data has been demonstrated for airborne L-band data but the quality of the focused tomographic images is limited by several factors. In particular, the common Fourierbased focusing methods are susceptible to irregular and sparse sampling, two problems, that are unavoidable in case of multi-pass, multi-baseline SAR data acquired by an airborne system. In this paper, a tomographic focusing method based on the time-domain back-projection algorithm is proposed, which maintains the geometric relationship between the original sensor positions and the imaged target and is therefore able to cope with irregular sampling without introducing any approximations with respect to the geometry. The tomographic focusing quality is assessed by analysing the impulse response of simulated point targets and an in-scene corner reflector. And, in particular, several tomographic slices of a volume representing a forested area are given. The respective P-band tomographic data set consisting of eleven flight tracks has been acquired by the airborne E-SAR sensor of the German Aerospace Center (DLR).

A Toolbox for Imaging Stellar Surfaces

NASA Astrophysics Data System (ADS)

Young, John

2018-04-01

In this talk I will review the available algorithms for synthesis imaging at visible and infrared wavelengths, including both gray and polychromatic methods. I will explain state-of-the-art approaches to constraining the ill-posed image reconstruction problem, and selecting an appropriate regularisation function and strength of regularisation. The reconstruction biases that can follow from non-optimal choices will be discussed, including their potential impact on the physical interpretation of the results. This discussion will be illustrated with example stellar surface imaging results from real VLTI and COAST datasets.

Constraining Convection Properties with VLTI

NASA Astrophysics Data System (ADS)

Paladini, Claudia

2018-04-01

We recently imaged the stellar surface of the asymptotic giant branch (AGB) star pi1 Gruis using the PIONIER instrument mounted on the Very Large Telescope Interferometer. The three images are very little contaminated by molecular and dust opacity, and show a stellar surface characterized by large convective granulation. In this contribution I will describe the method used to derive the size of the granulation pattern, the challenges of image reconstruction, and our results. I will conclude describing shortly what the next generation of interferometric instruments will bring to our study.

SAND: an automated VLBI imaging and analysing pipeline - I. Stripping component trajectories

NASA Astrophysics Data System (ADS)

Zhang, M.; Collioud, A.; Charlot, P.

2018-02-01

We present our implementation of an automated very long baseline interferometry (VLBI) data-reduction pipeline that is dedicated to interferometric data imaging and analysis. The pipeline can handle massive VLBI data efficiently, which makes it an appropriate tool to investigate multi-epoch multiband VLBI data. Compared to traditional manual data reduction, our pipeline provides more objective results as less human interference is involved. The source extraction is carried out in the image plane, while deconvolution and model fitting are performed in both the image plane and the uv plane for parallel comparison. The output from the pipeline includes catalogues of CLEANed images and reconstructed models, polarization maps, proper motion estimates, core light curves and multiband spectra. We have developed a regression STRIP algorithm to automatically detect linear or non-linear patterns in the jet component trajectories. This algorithm offers an objective method to match jet components at different epochs and to determine their proper motions.

Watching a 'New Star' Make the Universe Dusty

NASA Astrophysics Data System (ADS)

2008-07-01

Using ESO's Very Large Telescope Interferometer, and its remarkable acuity, astronomers were able for the first time to witness the appearance of a shell of dusty gas around a star that had just erupted, and follow its evolution for more than 100 days. This provides the astronomers with a new way to estimate the distance of this object and obtain invaluable information on the operating mode of stellar vampires, dense stars that suck material from a companion. Uncovering the disc ESO PR Photo 22/08 Dust shells around a nova Although novae were first thought to be new stars appearing in the sky, hence their Latin name, they are now understood as signaling the brightening of a small, dense star. Novae occur in double star systems comprising a white dwarf - the end product of a solar-like star - and, generally, a low-mass normal star - a red dwarf. The two stars are so close together that the red dwarf cannot hold itself together and loses mass to its companion. Occasionally, the shell of matter that has fallen onto the ingesting star becomes unstable, leading to a thermonuclear explosion which makes the system brighter. Nova Scorpii 2007a (or V1280 Scorpii), was discovered by Japanese amateur astronomers on 4 February 2007 towards the constellation Scorpius ("the Scorpion"). For a few days, it became brighter and brighter, reaching its maximum on 17 February, to become one of the brightest novae of the last 35 years. At that time, it was easily visible with the unaided eye. Eleven days after reaching its maximum, astronomers witnessed the formation of dust around the object. Dust was present for more than 200 days, as the nova only slowly emerged from the smoke between October and November 2007. During these 200 days, the erupting source was screened out efficiently, becoming more than 10,000 times dimmer in the visual. An unprecedented high spatial resolution monitoring of the dust formation event was carried out with the Very Large Telescope Interferometer (VLTI), extending over more than 5 months following the discovery. The astronomers first used the AMBER near-infrared instrument, then, as the nova continued to produce dust at a high rate, they moved to using the MIDI mid-infrared instrument, that is more sensitive to the radiation of the hot dust. Similarly, as the nova became fainter, the astronomers switched from the 1.8-m Auxiliary Telescopes to their larger brethren, the 8.2-m Unit Telescopes. With the interferometry mode, the resolution obtained is equivalent to using a telescope with a size between 35 and 71 metres (the distance between the 2 telescopes used). The first observations, secured 23 days after the discovery, showed that the source was very compact, less than 1 thousandth of an arcsecond (1 milli-arcsecond or mas), which is a size comparable to viewing one grain of sand from about 100 kilometres away. A few days later, after the detection of the major dust formation event, the source measured 13 mas. "It is most likely that the latter size corresponds to the diameter of the dust shell in expansion, while the size previously measured was an upper limit of the erupting source," explains lead author Olivier Chesneau. Over the following months the dusty shell expanded regularly, at a rate close to 2 million km/h. "This is the first time that the dust shell of a nova is spatially resolved and its evolution traced starting from the onset of its formation up to the point that it becomes too diluted to be seen", says co-author Dipankar Banerjee, from India. The measurement of the angular expansion rate, together with the knowledge of the expansion velocity, enables the astronomer to derive the distance of the object, in this case about 5500 light-years. "This is a new and promising technique for providing distances of close novae. This was made possible because the state of the art facility of the VLTI, both in terms of infrastructure and management of the observations, allows one to schedule such observations," says co-author Markus Wittkowski from ESO. Moreover, the quality of the data provided by the VLTI was such that it was possible to estimate the daily production of dust and infer the total mass ejected. "Overall, V1280 Sco probably ejected more than the equivalent of 33 times the mass of the Earth, a rather impressive feat if one considers that this mass was ejected from a star not larger in radius than the Earth," concludes Chesneau. Of this material, about a percent or less was in the form of dust.

Happy Anniversary, VLT !

NASA Astrophysics Data System (ADS)

2004-04-01

Five years at the service of Europe's astronomers VLT 5 Years One of the world's most advanced astronomical research facilities, the ESO Very Large Telescope (VLT) at the Paranal Observatory in the Chilean Atacama desert, celebrates an important anniversary today. On April 1, 1999, and following almost one year of extensive tests and careful trimming of its numerous high-tech parts, the first 8.2-m VLT Unit Telescope, Antu (UT1), was "handed over" to the astronomers. Since that date, science operations with this marvellous research tool have been continuous and intensive. Kueyen (UT2) started normal operations exactly one year later. Yepun (UT4) was offered to the scientific community in June 2001, while Melipal (UT3) followed in August 2001 [1]. Ever since, all four VLT Unit Telescopes, with an ever-growing suite of highly specialised, extremely powerful astronomical instruments have been in full operation, 365 nights a year. And this with unequalled success, as demonstrated by a long list of important scientific results, including a substantial number of exciting discoveries that are now opening new horizons in astrophysics. Moreover, thanks to heroic and persistent efforts by the dedicated teams of ESO scientists and engineers, the "downtime" due to technical problems has been very small, about 3 per cent, a number that is unequalled among the world's large telescope facilities. In addition, the weather conditions at the Paranal site in the dry Atacama desert in Northern Chile are truly excellent - this is indeed one of the best locations for astronomical observations on the surface of the Earth - and the corresponding "weather downtime" has only been around 10 per cent. This has resulted in an unbelievably low value of total downtime, most likely a new world record for ground-based 8-10 m class telescopes. VLT strong points The Very Large Telescope (VLT) is the world's largest and most advanced optical telescope. It comprises four 8.2-m reflecting Unit Telescopes (UTs) and will in due time also include four moving 1.8-m Auxiliary Telescopes (ATs), the first one of which successfully passed its first tests in January of this year (see ESO PR 01/04). With unprecedented optical resolution and unsurpassed surface area, the VLT produces extremely sharp images and can record light from the faintest and most remote objects in the Universe. It works at the limit of modern technology, regularly allowing the scientists to peer into new and unknown territories in the immense Universe. Contrary to other large astronomical telescopes, the VLT was designed from the beginning with the use of interferometry as a major goal. For this reason, the four 8.2-m Unit Telescopes were positioned in a quasi-trapezoidal configuration. The light beams from these telescopes, at this moment two-by-two, can be combined in the VLT Interferometer (VLTI). It provides the European scientific community with a ground-based telescope array with collecting power significantly greater than any other facilities available at present or being planned, offering imaging and spectroscopy capabilities at visible and infrared wavelengths. Seven of the planned ten first-generation astronomical instruments are now in operation at the VLT. They cover all major observing modes required to tackle current "hot", front-line research topics: * the multi-mode instrument FORS1 (FOcal Reducer and Spectrograph) and its twin, FORS2, * the Infrared Spectrometer And Array Camera (ISAAC) cryogenic infrared imager and spectrometer, * the UVES (Ultra-violet and Visible Echelle Spectrograph) high-dispersion spectrograph, * the NAOS-CONICA Adaptive Optics facility producing images as sharp as if taken in space [2], * the VIsible Multi-Object Spectrograph (VIMOS) four-channel multiobject spectrograph and imager - allowing to obtain low-resolution spectra of up to 1000 galaxies at a time * the Fibre Large Array Multi-Element Spectrograph (FLAMES) that offers the unique capability to study simultaneously and at high spectral resolution 100 individual stars in nearby galaxies. The remaining instruments - the high-resolution infrared spectrograph CRIRES, the Mid Infrared Spectrometer/Imager VISIR and the integral field spectrograph SINFONI - will be installed in 2004-2005. The observational statistics prove that these instruments are extremely efficient - they have some of the highest "shutter-open times" (i.e. percentage of the maximum possible observing time during which the instruments are collecting light from the astronomical objects) ever achieved. The astronomers are well served in this respect: the ISAAC instrument, for example, continues to be in the highest demand and has now performed smoothly during more than 1000 nights and two others, UVES and FORS, are now approaching the same number. Working together with astronomers and engineers at many research institutes in the ten ESO member countries, ESO is now in the process of defining second generation instruments and feasibility studies are well under way. Among the prime projects in this direction are a cryogenic multi-object spectrometer in the near-infrared 1 to 2.4 μm range ("KMOS"), a medium-resolution wide-band (0.32 to 2.4 μm) spectrometer ("X-shooter"), as well as a wide-field 3D optical spectrometer ("3D deep-field surveyor") and a high-contrast, adaptive optics assisted, imager ("planet finder"). In addition to these highly innovative instruments for the VLT UTs, specific instruments that will work with the combined light from several of the telescopes have also been conceived. The interferometric instrument MIDI will be offered to the astronomical community from today (April 1, 2004), fulfilling the VLTI promise. Great efforts have indeed gone into making observations with this very complex science machine as user-friendly as possible. Contrary to what is normally the case in this technically demanding branch of astronomy, scientists will find interferometric work at the VLTI quite similar to that of using the many other, more conventional VLT instruments. Science with the VLT The impressive battery of top-ranking instruments, coupled with the enormous light-collecting power of the VLT, has already provided a real research bonanza with many outstanding scientific results, some of which have been true breakthroughs. They include the amazing new knowledge about the Black Hole at the Galactic Centre, the farthest galaxy known, the most metal-poor and hence, oldest stars, accurate cosmochronological dating by means of Uranium and Thorium spectral lines, high-redshift galaxy rotation curves, micro-quasars, properties of the optical counterparts of gamma-ray bursts, high-redshift supernovae, etc. [3]. All of these advances attest to the power of the VLT and its mode of operational. Not to be forgotten is also the beauty of many of the stunning images obtained with this telescope, one of which was voted amongst the 10 most inspirational astronomical images of the past century [4]. Look at the numerous and detailed ESO Press Releases for more examples of research achievements from the VLT. This trend is also apparent in the productivity of the telescopes. The number of research publications resulting from VLT work in top ranking astronomical journals is steadily increasing with a total close to 700, hereof 250 in 2003 alone. Moreover, research articles based on VLT data are in the mean quoted twice as often as the average. The very high efficiency of the VLT "science machine" now generates huge amounts of data at a very high rate. These are stored in a permanent Science Archive Facility at ESO headquarters, which is jointly operated by ESO and the Space Telescope European Coordinating Facility (ST-ECF). From here, data are distributed daily to astronomers on DVDs and over the World Wide Web. The archive facility has been conceived and developed to enable astronomers to "mine" very efficiently the enormous volumes of data that is collected from the VLT. The archive now contains more than 1 million images or spectra taken by the four UTs with a total volume of about 50 Terabytes (50,000,000,000,000 bytes) of data. This corresponds to the content of about 25 million books of 1000 pages each; they would occupy more than 1000 kilometres of bookshelves! Looking towards the future Says Catherine Cesarsky, ESO Director General since 1999: " The Paranal Observatory has already given rise to an impressive number of scientific results, many of which could not have been obtained elsewhere. Overall, the VLT has been a most remarkable success, and will contribute to science at the highest level for years to come - a fantastic achievement of which we can all be justifiably proud." The work is now underway at full power to provide second-generation instruments for the VLT, to add three more Auxiliary Telescopes to the VLTI and to complement this unique research facility with the two wide-field survey ("pathfinding") telescopes - one to work in the visible part of the spectrum (the 2.5-m VST), the other in the infrared (the 4-m VISTA) - now being constructed at Paranal. Roberto Gilmozzi, director of Paranal Observatory, looks forward: " Ever more exciting times lie ahead for Paranal with new instruments like VISIR and SINFONI and the laser guide star, all of them coming this year. Five years after the start of operations on UT1, the observatory operates its telescopes with very little time set aside for engineering (less than 10%) and very low technical down time. Combined with excellent weather and great image quality, we provide the European community with unsurpassed observing capabilities. As director of this observatory since 1999, I have been privileged to be part of this adventure." The VLT is a fine example of the vast benefits of pooling resources from several countries and it is a flagship of contemporary European research. There is little doubt that for many years to come, ESO's Paranal Observatory with its powerful and efficient facilities will continue to play a leading role in astronomical research. Information for the media Associated material can be found on the corresponding Press Events webpage.

Respiratory motor training and neuromuscular plasticity in patients with chronic obstructive pulmonary disease: A pilot study.

PubMed

Ovechkin, Alexander V; Sayenko, Dimitry G; Ovechkina, Elena N; Aslan, Sevda C; Pitts, Teresa; Folz, Rodney J

2016-07-15

The objective of this study was to examine the feasibility of a full-scale investigation of the neurophysiological mechanisms of COPD-induced respiratory neuromuscular control deficits. Characterization of respiratory single- and multi-muscle activation patterns using surface electromyography (sEMG) were assessed along with functional measures at baseline and following 21±2 (mean±SD) sessions of respiratory motor training (RMT) performed during a one-month period in four patients with GOLD stage II or III COPD. Pre-training, the individuals with COPD showed significantly increased (p<0.05) overall respiratory muscle activity and disorganized multi-muscle activation patterns in association with lowered spirometrical measures and decreased fast- and slow-twitch fiber activity as compared to healthy controls (N=4). Following RMT, functional and respiratory sEMG activation outcomes during quite breathing and forced expiratory efforts were improved suggesting that functional improvements, induced by task-specific RMT, are evidence respiratory neuromuscular networks re-organization. Published by Elsevier B.V.

A demonstration of high precision GPS orbit determination for geodetic applications

NASA Technical Reports Server (NTRS)

Lichten, S. M.; Border, J. S.

1987-01-01

High precision orbit determination of Global Positioning System (GPS) satellites is a key requirement for GPS-based precise geodetic measurements and precise low-earth orbiter tracking, currently under study at JPL. Different strategies for orbit determination have been explored at JPL with data from a 1985 GPS field experiment. The most successful strategy uses multi-day arcs for orbit determination and includes fine tuning of spacecraft solar pressure coefficients and station zenith tropospheric delays using the GPS data. Average rms orbit repeatability values for 5 of the GPS satellites are 1.0, 1.2, and 1.7 m in altitude, cross-track, and down-track componenets when two independent 5-day fits are compared. Orbit predictions up to 24 hours outside the multi-day arcs agree within 4 m of independent solutions obtained with well tracked satellites in the prediction interval. Baseline repeatability improves with multi-day as compared to single-day arc orbit solutions. When tropospheric delay fluctuations are modeled with process noise, significant additional improvement in baseline repeatability is achieved. For a 246-km baseline, with 6-day arc solutions for GPS orbits, baseline repeatability is 2 parts in 100 million (0.4-0.6 cm) for east, north, and length components and 8 parts in 100 million for the vertical component. For 1314 and 1509 km baselines with the same orbits, baseline repeatability is 2 parts in 100 million for the north components (2-3 cm) and 4 parts in 100 million or better for east, length, and vertical components.

Multi-objective Optimization Design of Gear Reducer Based on Adaptive Genetic Algorithms

NASA Astrophysics Data System (ADS)

Li, Rui; Chang, Tian; Wang, Jianwei; Wei, Xiaopeng; Wang, Jinming

2008-11-01

An adaptive Genetic Algorithm (GA) is introduced to solve the multi-objective optimized design of the reducer. Firstly, according to the structure, strength, etc. in a reducer, a multi-objective optimized model of the helical gear reducer is established. And then an adaptive GA based on a fuzzy controller is introduced, aiming at the characteristics of multi-objective, multi-parameter, multi-constraint conditions. Finally, a numerical example is illustrated to show the advantages of this approach and the effectiveness of an adaptive genetic algorithm used in optimized design of a reducer.

Sensitivity analysis of multi-objective optimization of CPG parameters for quadruped robot locomotion

NASA Astrophysics Data System (ADS)

Oliveira, Miguel; Santos, Cristina P.; Costa, Lino

2012-09-01

In this paper, a study based on sensitivity analysis is performed for a gait multi-objective optimization system that combines bio-inspired Central Patterns Generators (CPGs) and a multi-objective evolutionary algorithm based on NSGA-II. In this system, CPGs are modeled as autonomous differential equations, that generate the necessary limb movement to perform the required walking gait. In order to optimize the walking gait, a multi-objective problem with three conflicting objectives is formulated: maximization of the velocity, the wide stability margin and the behavioral diversity. The experimental results highlight the effectiveness of this multi-objective approach and the importance of the objectives to find different walking gait solutions for the quadruped robot.

Six weeks of multi-station program on the knee proprioception and performance of futsal players.

PubMed

Pérez-Silvestre, Ángel; Albert-Lucena, Daniel; Gómez-Chiguano, Guido F; Plaza-Manzano, Gustavo; Pecos-Martín, Daniel; Gallego-Izquierdo, Tomás; Martín-Casas, Patricia; Romero-Franco, Natalia

2018-03-27

Proprioception and vertical jump are important parameters in the performance and prevention of injuries in futsal. However, very few studies have analyzed the role of multi-station exercises to improve these variables. The purpose of this study was to assess the effects of a six-week multi-station exercise program on knee joint position sense (JPS) and countermovement jump (CMJ) of futsal players. Thirty-four male futsal players randomly classified into experimental (n = 17) or control group (n = 17). The experimental group included a multi-station exercise protocol to their training routines (2 times/week - 6 weeks); the control group continued their training routines. All the players completed similar training routines outside of the multi-station exercises. Before (baseline), just after the intervention (Post6Wk) and four weeks later (Post10Wk), CMJ and knee JPS (absolute, relative and variable angular error: AAE, RAE and VAE, respectively) were evaluated. ANOVA showed that the experimental group significantly decreased VAE at Post10Wk compared to baseline, suggestive of greater proprioceptive precision, while the control group significantly increased AAE, RAE and VAE at Post10Wk compared to baseline. The experimental group exhibited lower and thus, better AAE and VAE than the control group at Post10Wk, although no significant differences were found at Post6Wk. No significant differences was found in the CMJ. A six weeks of multi-station program may help improve proprioceptive precision of futsal players, even one month after finishing the 6-wk multi-station training program. However, this is not long enough to improve proprioceptive acuity and maximum vertical jump. Therefore, the meaningful of these results in term of performance are unclear.

MoonBEAM: A Beyond Earth-Orbit Gamma-Ray Burst Detector for Gravitational-Wave Astronomy

NASA Technical Reports Server (NTRS)

Hui, C. M.; Briggs, M. S.; Goldstein, A. M.; Jenke, P. A.; Kocevski, D.; Wilson-Hodge, C. A.

2018-01-01

Moon Burst Energetics All-sky Monitor (MoonBEAM) is a CubeSat concept of deploying gamma-ray detectors in cislunar space to improve localization precision for gamma-ray bursts by utilizing the light travel time difference between different orbits. We present here a gamma-ray SmallSat concept in Earth-Moon L3 halo orbit that is capable of rapid response and provide a timing baseline for localization improvement when partnered with an Earth-orbit instrument. Such an instrument would probe the extreme processes in cosmic collision of compact objects and facilitate multi-messenger time-domain astronomy to explore the end of stellar life cycles and black hole formations.

Mapping Forest Height in Gabon Using UAVSAR Multi-Baseline Polarimetric SAR Interferometry and Lidar Fusion

NASA Astrophysics Data System (ADS)

Simard, M.; Denbina, M. W.

2017-12-01

Using data collected by NASA's Uninhabited Aerial Vehicle Synthetic Aperture Radar (UAVSAR) and Land, Vegetation, and Ice Sensor (LVIS) lidar, we have estimated forest canopy height for a number of study areas in the country of Gabon using a new machine learning data fusion approach. Using multi-baseline polarimetric synthetic aperture radar interferometry (PolInSAR) data collected by UAVSAR, forest heights can be estimated using the random volume over ground model. In the case of multi-baseline UAVSAR data consisting of many repeat passes with spatially separated flight tracks, we can estimate different forest height values for each different image pair, or baseline. In order to choose the best forest height estimate for each pixel, the baselines must be selected or ranked, taking care to avoid baselines with unsuitable spatial separation, or severe temporal decorrelation effects. The current baseline selection algorithms in the literature use basic quality metrics derived from the PolInSAR data which are not necessarily indicative of the true height accuracy in all cases. We have developed a new data fusion technique which treats PolInSAR baseline selection as a supervised classification problem, where the classifier is trained using a sparse sampling of lidar data within the PolInSAR coverage area. The classifier uses a large variety of PolInSAR-derived features as input, including radar backscatter as well as features based on the PolInSAR coherence region shape and the PolInSAR complex coherences. The resulting data fusion method produces forest height estimates which are more accurate than a purely radar-based approach, while having a larger coverage area than the input lidar training data, combining some of the strengths of each sensor. The technique demonstrates the strong potential for forest canopy height and above-ground biomass mapping using fusion of PolInSAR with data from future spaceborne lidar missions such as the upcoming Global Ecosystems Dynamics Investigation (GEDI) lidar.

Improved multi-objective ant colony optimization algorithm and its application in complex reasoning

NASA Astrophysics Data System (ADS)

Wang, Xinqing; Zhao, Yang; Wang, Dong; Zhu, Huijie; Zhang, Qing

2013-09-01

The problem of fault reasoning has aroused great concern in scientific and engineering fields. However, fault investigation and reasoning of complex system is not a simple reasoning decision-making problem. It has become a typical multi-constraint and multi-objective reticulate optimization decision-making problem under many influencing factors and constraints. So far, little research has been carried out in this field. This paper transforms the fault reasoning problem of complex system into a paths-searching problem starting from known symptoms to fault causes. Three optimization objectives are considered simultaneously: maximum probability of average fault, maximum average importance, and minimum average complexity of test. Under the constraints of both known symptoms and the causal relationship among different components, a multi-objective optimization mathematical model is set up, taking minimizing cost of fault reasoning as the target function. Since the problem is non-deterministic polynomial-hard(NP-hard), a modified multi-objective ant colony algorithm is proposed, in which a reachability matrix is set up to constrain the feasible search nodes of the ants and a new pseudo-random-proportional rule and a pheromone adjustment mechinism are constructed to balance conflicts between the optimization objectives. At last, a Pareto optimal set is acquired. Evaluation functions based on validity and tendency of reasoning paths are defined to optimize noninferior set, through which the final fault causes can be identified according to decision-making demands, thus realize fault reasoning of the multi-constraint and multi-objective complex system. Reasoning results demonstrate that the improved multi-objective ant colony optimization(IMACO) can realize reasoning and locating fault positions precisely by solving the multi-objective fault diagnosis model, which provides a new method to solve the problem of multi-constraint and multi-objective fault diagnosis and reasoning of complex system.

Multi-Objectivising Combinatorial Optimisation Problems by Means of Elementary Landscape Decompositions.

PubMed

Ceberio, Josu; Calvo, Borja; Mendiburu, Alexander; Lozano, Jose A

2018-02-15

In the last decade, many works in combinatorial optimisation have shown that, due to the advances in multi-objective optimisation, the algorithms from this field could be used for solving single-objective problems as well. In this sense, a number of papers have proposed multi-objectivising single-objective problems in order to use multi-objective algorithms in their optimisation. In this article, we follow up this idea by presenting a methodology for multi-objectivising combinatorial optimisation problems based on elementary landscape decompositions of their objective function. Under this framework, each of the elementary landscapes obtained from the decomposition is considered as an independent objective function to optimise. In order to illustrate this general methodology, we consider four problems from different domains: the quadratic assignment problem and the linear ordering problem (permutation domain), the 0-1 unconstrained quadratic optimisation problem (binary domain), and the frequency assignment problem (integer domain). We implemented two widely known multi-objective algorithms, NSGA-II and SPEA2, and compared their performance with that of a single-objective GA. The experiments conducted on a large benchmark of instances of the four problems show that the multi-objective algorithms clearly outperform the single-objective approaches. Furthermore, a discussion on the results suggests that the multi-objective space generated by this decomposition enhances the exploration ability, thus permitting NSGA-II and SPEA2 to obtain better results in the majority of the tested instances.

Upper Airway Stimulation for Obstructive Sleep Apnea: Results from the ADHERE Registry.

PubMed

Boon, Maurits; Huntley, Colin; Steffen, Armin; Maurer, Joachim T; Sommer, J Ulrich; Schwab, Richard; Thaler, Erica; Soose, Ryan; Chou, Courtney; Strollo, Patrick; Kezirian, Eric J; Chia, Stanley; Withrow, Kirk; Weidenbecher, Mark; Strohl, Kingman; Doghramji, Karl; Hofauer, Benedikt; Heiser, Clemens

2018-03-01

Objective Upper airway stimulation (UAS) is an alternative treatment option for patients unable to tolerate continuous positive airway pressure (CPAP) for the treatment of obstructive sleep apnea (OSA). Studies support the safety and efficacy of this therapy. The aim of this registry is to collect retrospective and prospective objective and subjective outcome measures across multiple institutions in the United States and Germany. To date, it represents the largest cohort of patients studied with this therapy. Study Design Retrospective and prospective registry study. Setting Ten tertiary care hospitals in the United States and Germany. Subjects and Methods Patients were included who had moderate to severe OSA, were intolerant to CPAP, and were undergoing UAS implantation. Baseline demographic and sleep study data were collected. Objective and subjective treatment outcomes, adverse events, and patient and physician satisfaction were reviewed. Results The registry enrolled 301 patients between October 2016 and September 2017. Mean ± SD AHI decreased from 35.6 ± 15.3 to 10.2 ± 12.9 events per hour ( P < .0001), and Epworth Sleepiness Scale scores decreased from 11.9 ± 5.5 to 7.5 ± 4.7 ( P < .0001) from baseline to the posttitration visit. Patients utilized therapy for 6.5 hours per night. There were low rates of procedure- and device-related complications. Clinical global impression scores demonstrated that the majority of physicians (94%) saw improvement in their patients' symptoms with therapy. The majority of patients (90%) were more satisfied with UAS than CPAP. Conclusions Across a multi-institutional registry, UAS therapy demonstrates significant improvement in subjective and objective OSA outcomes, good therapy adherence, and high patient satisfaction.

An adaptive evolutionary multi-objective approach based on simulated annealing.

PubMed

Li, H; Landa-Silva, D

2011-01-01

A multi-objective optimization problem can be solved by decomposing it into one or more single objective subproblems in some multi-objective metaheuristic algorithms. Each subproblem corresponds to one weighted aggregation function. For example, MOEA/D is an evolutionary multi-objective optimization (EMO) algorithm that attempts to optimize multiple subproblems simultaneously by evolving a population of solutions. However, the performance of MOEA/D highly depends on the initial setting and diversity of the weight vectors. In this paper, we present an improved version of MOEA/D, called EMOSA, which incorporates an advanced local search technique (simulated annealing) and adapts the search directions (weight vectors) corresponding to various subproblems. In EMOSA, the weight vector of each subproblem is adaptively modified at the lowest temperature in order to diversify the search toward the unexplored parts of the Pareto-optimal front. Our computational results show that EMOSA outperforms six other well established multi-objective metaheuristic algorithms on both the (constrained) multi-objective knapsack problem and the (unconstrained) multi-objective traveling salesman problem. Moreover, the effects of the main algorithmic components and parameter sensitivities on the search performance of EMOSA are experimentally investigated.

Digital fabrication of multi-material biomedical objects.

PubMed

Cheung, H H; Choi, S H

2009-12-01

This paper describes a multi-material virtual prototyping (MMVP) system for modelling and digital fabrication of discrete and functionally graded multi-material objects for biomedical applications. The MMVP system consists of a DMMVP module, an FGMVP module and a virtual reality (VR) simulation module. The DMMVP module is used to model discrete multi-material (DMM) objects, while the FGMVP module is for functionally graded multi-material (FGM) objects. The VR simulation module integrates these two modules to perform digital fabrication of multi-material objects, which can be subsequently visualized and analysed in a virtual environment to optimize MMLM processes for fabrication of product prototypes. Using the MMVP system, two biomedical objects, including a DMM human spine and an FGM intervertebral disc spacer are modelled and digitally fabricated for visualization and analysis in a VR environment. These studies show that the MMVP system is a practical tool for modelling, visualization, and subsequent fabrication of biomedical objects of discrete and functionally graded multi-materials for biomedical applications. The system may be adapted to control MMLM machines with appropriate hardware for physical fabrication of biomedical objects.

On the Location of the gamma-Ray Outburst Emission in the BL Lacertae Object AO 0235 + 164 Through Observations Across the Electromagnetic Spectrum

NASA Technical Reports Server (NTRS)

Agudo, Ivan; Marscher, Alan P.; Jorstad, Svetlana G.; Larionov, Valeri M.; Gomez, Jose L.; Laehteenmaeki, Anne; Smith, Paul S.; Nilsson, Kari; Readhead, Anthony C. S.; Aller, Margo F.;

The Beagle 2 Stereo Camera System: Scientific Objectives and Design Characteristics

NASA Astrophysics Data System (ADS)

Griffiths, A.; Coates, A.; Josset, J.; Paar, G.; Sims, M.

2003-04-01

The Stereo Camera System (SCS) will provide wide-angle (48 degree) multi-spectral stereo imaging of the Beagle 2 landing site in Isidis Planitia with an angular resolution of 0.75 milliradians. Based on the SpaceX Modular Micro-Imager, the SCS is composed of twin cameras (with 1024 by 1024 pixel frame transfer CCD) and twin filter wheel units (with a combined total of 24 filters). The primary mission objective is to construct a digital elevation model of the area in reach of the lander’s robot arm. The SCS specifications and following baseline studies are described: Panoramic RGB colour imaging of the landing site and panoramic multi-spectral imaging at 12 distinct wavelengths to study the mineralogy of landing site. Solar observations to measure water vapour absorption and the atmospheric dust optical density. Also envisaged are multi-spectral observations of Phobos &Deimos (observations of the moons relative to background stars will be used to determine the lander’s location and orientation relative to the Martian surface), monitoring of the landing site to detect temporal changes, observation of the actions and effects of the other PAW experiments (including rock texture studies with a close-up-lens) and collaborative observations with the Mars Express orbiter instrument teams. Due to be launched in May of this year, the total system mass is 360 g, the required volume envelope is 747 cm^3 and the average power consumption is 1.8 W. A 10Mbit/s RS422 bus connects each camera to the lander common electronics.

Multi-Objective Optimization for Speed and Stability of a Sony AIBO Gait

DTIC Science & Technology

2007-09-01

MULTI-OBJECTIVE OPTIMIZATION FOR SPEED AND STABILITY OF A SONY AIBO GAIT THESIS Christopher A. Patterson, Second Lieutenant, USAF AFIT/GCS...07-17 MULTI-OBJECTIVE OPTIMIZATION FOR SPEED AND STABILITY OF A SONY AIBO GAIT THESIS Presented to the Faculty Department of...MULTI-OBJECTIVE OPTIMIZATION FOR SPEED AND STABILITY OF A SONY AIBO GAIT Christopher A. Patterson, BS Second Lieutenant, USAF

A randomized, double-blind, placebo-controlled study of the effects of pomegranate extract on rising PSA levels in men following primary therapy for prostate cancer.

PubMed

Pantuck, A J; Pettaway, C A; Dreicer, R; Corman, J; Katz, A; Ho, A; Aronson, W; Clark, W; Simmons, G; Heber, D

2015-09-01

The primary objective of this study was to compare the effects of pomegranate juice on PSA doubling times (PSADT) in subjects with rising PSA levels after primary therapy for prostate cancer. Double-blind, placebo-controlled multi-institutional study, evaluated the effects of pomegranate liquid extract on serum PSA levels. The primary end point of this study was change in serum PSADT. Additional secondary and exploratory objectives were to evaluate the safety of pomegranate juice and to determine the interaction of manganese superoxide dismutase (MnSOD) AA genotype and pomegranate treatment on PSADT. One-hundred eighty-three eligible subjects were randomly assigned to the active and placebo groups with a ratio of 2:1 (extract N=102; placebo N=64; juice N=17). The majority of adverse events were of moderate or mild grade. Median PSADT increased from 11.1 months at baseline to 15.6 months in the placebo group (P<0.001) compared with an increase from 12.9 months at baseline to 14.5 months in the extract group (P=0.13) and an increase from 12.7 at baseline to 20.3 in the juice group (P=0.004). However, none of these changes were statistically significant between the three groups (P>0.05). Placebo AA patients experienced a 1.8 month change in median PSADT from 10.9 months at baseline to 12.7 months (P=0.22), while extract patients experienced a 12 month change in median PSADT from 13.6 at baseline to 25.6 months (P=0.03). Compared with placebo, pomegranate extract did not significantly prolong PSADT in prostate cancer patients with rising PSA after primary therapy. A significant prolongation in PSADT was observed in both the treatment and placebo arms. Men with the MnSOD AA genotype may represent a group that is more sensitive to the antiproliferative effects of pomegranate on PSADT; however, this finding requires prospective hypothesis testing and validation.

Description of the F-16XL Geometry and Computational Grids Used in CAWAPI

NASA Technical Reports Server (NTRS)

Boelens, O. J.; Badcock, K. J.; Gortz, S.; Morton, S.; Fritz, W.; Karman, S. L., Jr.; Michal, T.; Lamar, J. E.

2009-01-01

The objective of the Cranked-Arrow Wing Aerodynamics Project International (CAWAPI) was to allow a comprehensive validation of Computational Fluid Dynamics methods against the CAWAP flight database. A major part of this work involved the generation of high-quality computational grids. Prior to the grid generation an IGES file containing the air-tight geometry of the F-16XL aircraft was generated by a cooperation of the CAWAPI partners. Based on this geometry description both structured and unstructured grids have been generated. The baseline structured (multi-block) grid (and a family of derived grids) has been generated by the National Aerospace Laboratory NLR. Although the algorithms used by NLR had become available just before CAWAPI and thus only a limited experience with their application to such a complex configuration had been gained, a grid of good quality was generated well within four weeks. This time compared favourably with that required to produce the unstructured grids in CAWAPI. The baseline all-tetrahedral and hybrid unstructured grids has been generated at NASA Langley Research Center and the USAFA, respectively. To provide more geometrical resolution, trimmed unstructured grids have been generated at EADS-MAS, the UTSimCenter, Boeing Phantom Works and KTH/FOI. All grids generated within the framework of CAWAPI will be discussed in the article. Both results obtained on the structured grids and the unstructured grids showed a significant improvement in agreement with flight test data in comparison with those obtained on the structured multi-block grid used during CAWAP.

Proceedings of a workshop: Multidisciplinary Use of the Very Long Baseline Array

NASA Technical Reports Server (NTRS)

1984-01-01

The National Research Council organized a workshop to gather together experts in very long baseline interometry, astronomy, space navigation, general relativity and the earth sciences. The purpose of the workshop was to provide a forum for consideration of the various possible multi-disciplinary uses of the very long baseline array. Geophysical investigations received major attention. Geodesic uses of the very long baseline array were identified as were uses for fundamental astronomy investigations. Numerous specialized uses were identified.

Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol in comparison to one containing levonorgestrel and ethinylestradiol on markers of endocrine function

PubMed Central

Ågren, Ulla M; Anttilat, Marjatta; Mäenpää-Liukko, Kristiina; Rantala, Maija-Liisa; Rautiainen, Hilkka; Sommer, Werner F; Mommers, Ellen

2011-01-01

Objectives To compare the effects of two monophasic combined oral contraceptives, containing either nomegestrol acetate/17β-oestradiol (NOMAC/E2) or levonorgestrel/ ethinylestradiol (LNG/EE) on endocrine function, androgens, and sex hormone-binding globulin (SHBG). Methods Randomised, open-label, multi-centre trial involving 121 healthy women, aged 18-50 years old. Participants received NOMAC/E2 (2.5 mg/1.5 mg) in a 24/4-day regimen (n = 60) or LNG/EE (150 μg/30 μg) in a 21/7-day regimen (n = 61) for six cycles. The primary outcome was the change from baseline to cycle 6 in markers of adrenal and thyroid function, androgens, and SHBG. Results Total cortisol, corticosteroid-binding globulin (CBG), and thyroxine-binding globulin (TBG) increased from baseline in both groups, with significantly greater increases in the LNG/EE group. No relevant changes from baseline or differences between the groups were observed for thyroid-stimulating hormone (TSH) and free thyroxine (T4). Androgens and androgen precursors decreased from baseline in both groups, with significantly greater decreases in the LNG/EE group (except for free testosterone). A greater increase in SHBG was observed with NOMAC/E2 than with LNG/EE. Conclusions NOMAC/E2 has significantly less influence on markers of adrenal and thyroid function and androgens than LNG/EE. The clinical relevance of these findings requires further study. PMID:21942708

Designing a multi-objective, multi-support accuracy assessment of the 2001 National Land Cover Data (NLCD 2001) of the conterminous United States

USGS Publications Warehouse

Stehman, S.V.; Wickham, J.D.; Wade, T.G.; Smith, J.H.

2008-01-01

The database design and diverse application of NLCD 2001 pose significant challenges for accuracy assessment because numerous objectives are of interest, including accuracy of land-cover, percent urban imperviousness, percent tree canopy, land-cover composition, and net change. A multi-support approach is needed because these objectives require spatial units of different sizes for reference data collection and analysis. Determining a sampling design that meets the full suite of desirable objectives for the NLCD 2001 accuracy assessment requires reconciling potentially conflicting design features that arise from targeting the different objectives. Multi-stage cluster sampling provides the general structure to achieve a multi-support assessment, and the flexibility to target different objectives at different stages of the design. We describe the implementation of two-stage cluster sampling for the initial phase of the NLCD 2001 assessment, and identify gaps in existing knowledge where research is needed to allow full implementation of a multi-objective, multi-support assessment. ?? 2008 American Society for Photogrammetry and Remote Sensing.

Precise Determination of the Baseline Between the TerraSAR-X and TanDEM-X Satellites

NASA Astrophysics Data System (ADS)

Koenig, Rolf; Rothacher, Markus; Michalak, Grzegorz; Moon, Yongjin

TerraSAR-X, launched on June 15, 2007, and TanDEM-X, to be launched in September 2009, both carry the Tracking, Occultation and Ranging (TOR) category A payload instrument package. The TOR consists of a high-precision dual-frequency GPS receiver, called Integrated GPS Occultation Receiver (IGOR), for precise orbit determination and atmospheric sounding and a Laser retro-reflector (LRR) serving as target for the global Satellite Laser Ranging (SLR) ground station network. The TOR is supplied by the GeoForschungsZentrum Potsdam (GFZ) Germany, and the Center for Space Research (CSR), Austin, Texas. The objective of the German/US collaboration is twofold: provision of atmospheric profiles for use in numerical weather predictions and climate studies from the occultation data and precision SAR data processing based on precise orbits and atmospheric products. For the scientific objectives of the TanDEM- X mission, i.e., bi-static SAR together with TerraSAR-X, the dual-frequency GPS receiver is of vital importance for the millimeter level determination of the baseline or distance between the two spacecrafts. The paper discusses the feasibility of generating millimeter baselines by the example of GRACE, where for validation the distance between the two GRACE satellites is directly available from the micrometer-level intersatellite link measurements. The distance of the GRACE satellites is some 200 km, the distance of the TerraSAR-X/TanDEM-X formation will be some 200 meters. Therefore the proposed approach is then subject to a simulation of the foreseen TerraSAR-X/TanDEM-X formation. The effect of varying space environmental conditions, of possible phase center variations, multi path, and of varying center of mass of the spacecrafts are evaluated and discussed.

Cluster analysis and prediction of treatment outcomes for chronic rhinosinusitis.

PubMed

Soler, Zachary M; Hyer, J Madison; Rudmik, Luke; Ramakrishnan, Viswanathan; Smith, Timothy L; Schlosser, Rodney J

2016-04-01

Current clinical classifications of chronic rhinosinusitis (CRS) have weak prognostic utility regarding treatment outcomes. Simplified discriminant analysis based on unsupervised clustering has identified novel phenotypic subgroups of CRS, but prognostic utility is unknown. We sought to determine whether discriminant analysis allows prognostication in patients choosing surgery versus continued medical management. A multi-institutional prospective study of patients with CRS in whom initial medical therapy failed who then self-selected continued medical management or surgical treatment was used to separate patients into 5 clusters based on a previously described discriminant analysis using total Sino-Nasal Outcome Test-22 (SNOT-22) score, age, and missed productivity. Patients completed the SNOT-22 at baseline and for 18 months of follow-up. Baseline demographic and objective measures included olfactory testing, computed tomography, and endoscopy scoring. SNOT-22 outcomes for surgical versus continued medical treatment were compared across clusters. Data were available on 690 patients. Baseline differences in demographics, comorbidities, objective disease measures, and patient-reported outcomes were similar to previous clustering reports. Three of 5 clusters identified by means of discriminant analysis had improved SNOT-22 outcomes with surgical intervention when compared with continued medical management (surgery was a mean of 21.2 points better across these 3 clusters at 6 months, P < .05). These differences were sustained at 18 months of follow-up. Two of 5 clusters had similar outcomes when comparing surgery with continued medical management. A simplified discriminant analysis based on 3 common clinical variables is able to cluster patients and provide prognostic information regarding surgical treatment versus continued medical management in patients with CRS. Copyright © 2015 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Self-reported post-exertional fatigue in Gulf War veterans: roles of autonomic testing

PubMed Central

Li, Mian; Xu, Changqing; Yao, Wenguo; Mahan, Clare M.; Kang, Han K.; Sandbrink, Friedhelm; Zhai, Ping; Karasik, Pamela A.

2014-01-01

To determine if objective evidence of autonomic dysfunction exists from a group of Gulf War veterans with self-reported post-exertional fatigue, we evaluated 16 Gulf War ill veterans and 12 Gulf War controls. Participants of the ill group had self- reported, unexplained chronic post-exertional fatigue and the illness symptoms had persisted for years until the current clinical study. The controls had no self-reported post-exertional fatigue either at the time of initial survey nor at the time of the current study. We intended to identify clinical autonomic disorders using autonomic and neurophysiologic testing in the clinical context. We compared the autonomic measures between the 2 groups on cardiovascular function at both baseline and head-up tilt, and sudomotor function. We identified 1 participant with orthostatic hypotension, 1 posture orthostatic tachycardia syndrome, 2 distal small fiber neuropathy, and 1 length dependent distal neuropathy affecting both large and small fiber in the ill group; whereas none of above definable diagnoses was noted in the controls. The ill group had a significantly higher baseline heart rate compared to controls. Compound autonomic scoring scale showed a significant higher score (95% CI of mean: 1.72–2.67) among ill group compared to controls (0.58–1.59). We conclude that objective autonomic testing is necessary for the evaluation of self-reported, unexplained post-exertional fatigue among some Gulf War veterans with multi-symptom illnesses. Our observation that ill veterans with self-reported post-exertional fatigue had objective autonomic measures that were worse than controls warrants validation in a larger clinical series. PMID:24431987

Multi-objective optimization of a continuous bio-dissimilation process of glycerol to 1, 3-propanediol.

PubMed

Xu, Gongxian; Liu, Ying; Gao, Qunwang

2016-02-10

This paper deals with multi-objective optimization of continuous bio-dissimilation process of glycerol to 1, 3-propanediol. In order to maximize the production rate of 1, 3-propanediol, maximize the conversion rate of glycerol to 1, 3-propanediol, maximize the conversion rate of glycerol, and minimize the concentration of by-product ethanol, we first propose six new multi-objective optimization models that can simultaneously optimize any two of the four objectives above. Then these multi-objective optimization problems are solved by using the weighted-sum and normal-boundary intersection methods respectively. Both the Pareto filter algorithm and removal criteria are used to remove those non-Pareto optimal points obtained by the normal-boundary intersection method. The results show that the normal-boundary intersection method can successfully obtain the approximate Pareto optimal sets of all the proposed multi-objective optimization problems, while the weighted-sum approach cannot achieve the overall Pareto optimal solutions of some multi-objective problems. Copyright © 2015 Elsevier B.V. All rights reserved.

Energy Decision Science and Informatics | Integrated Energy Solutions |

Science.gov Websites

Science Advanced decision science methods include multi-objective and multi-criteria decision support. Our decision science methods, including multi-objective and multi-criteria decision support. For example, we

EIT image regularization by a new Multi-Objective Simulated Annealing algorithm.

PubMed

Castro Martins, Thiago; Sales Guerra Tsuzuki, Marcos

2015-01-01

Multi-Objective Optimization can be used to produce regularized Electrical Impedance Tomography (EIT) images where the weight of the regularization term is not known a priori. This paper proposes a novel Multi-Objective Optimization algorithm based on Simulated Annealing tailored for EIT image reconstruction. Images are reconstructed from experimental data and compared with images from other Multi and Single Objective optimization methods. A significant performance enhancement from traditional techniques can be inferred from the results.

The effects of multi-disciplinary psycho-social care on socio-economic problems in cancer patients: a cluster-randomized trial.

PubMed

Singer, Susanne; Roick, Julia; Meixensberger, Jürgen; Schiefke, Franziska; Briest, Susanne; Dietz, Andreas; Papsdorf, Kirsten; Mössner, Joachim; Berg, Thomas; Stolzenburg, Jens-Uwe; Niederwieser, Dietger; Keller, Annette; Kersting, Anette; Danker, Helge

2018-06-01

We examined whether multi-disciplinary stepped psycho-social care decreases financial problems and improves return-to-work in cancer patients. In a university hospital, wards were randomly allocated to either stepped or standard care. Stepped care comprised screening for financial problems, consultation between doctor and patient, and the provision of social service. Outcomes were financial problems at the time of discharge and return-to-work in patients < 65 years old half a year after baseline. The analysis employed mixed-effect multivariate regression modeling. Thirteen wards were randomized and 1012 patients participated (n = 570 in stepped care and n = 442 in standard care). Those who reported financial problems at baseline were less likely to have financial problems at discharge when they had received stepped care (odds ratio (OR) 0.2, 95% confidence interval (CI) 0.1, 0.7; p = 0.01). There was no evidence for an effect of stepped care on financial problems in patients without such problems at baseline (OR 1.1, CI 0.5, 2.6; p = 0.82). There were 399 patients < 65 years old who were not retired at baseline. In this group, there was no evidence for an effect of stepped care on being employed half a year after baseline (OR 0.7, CI 0.3, 2.0; p = 0.52). NCT01859429 CONCLUSIONS: Financial problems can be avoided more effectively with multi-disciplinary stepped psycho-social care than with standard care in patients who have such problems.

Label-aligned Multi-task Feature Learning for Multimodal Classification of Alzheimer’s Disease and Mild Cognitive Impairment

PubMed Central

Zu, Chen; Jie, Biao; Liu, Mingxia; Chen, Songcan

2015-01-01

Multimodal classification methods using different modalities of imaging and non-imaging data have recently shown great advantages over traditional single-modality-based ones for diagnosis and prognosis of Alzheimer’s disease (AD), as well as its prodromal stage, i.e., mild cognitive impairment (MCI). However, to the best of our knowledge, most existing methods focus on mining the relationship across multiple modalities of the same subjects, while ignoring the potentially useful relationship across different subjects. Accordingly, in this paper, we propose a novel learning method for multimodal classification of AD/MCI, by fully exploring the relationships across both modalities and subjects. Specifically, our proposed method includes two subsequent components, i.e., label-aligned multi-task feature selection and multimodal classification. In the first step, the feature selection learning from multiple modalities are treated as different learning tasks and a group sparsity regularizer is imposed to jointly select a subset of relevant features. Furthermore, to utilize the discriminative information among labeled subjects, a new label-aligned regularization term is added into the objective function of standard multi-task feature selection, where label-alignment means that all multi-modality subjects with the same class labels should be closer in the new feature-reduced space. In the second step, a multi-kernel support vector machine (SVM) is adopted to fuse the selected features from multi-modality data for final classification. To validate our method, we perform experiments on the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database using baseline MRI and FDG-PET imaging data. The experimental results demonstrate that our proposed method achieves better classification performance compared with several state-of-the-art methods for multimodal classification of AD/MCI. PMID:26572145

Model Following and High Order Augmentation for Rotorcraft Control, Applied via Partial Authority

NASA Astrophysics Data System (ADS)

Spires, James Michael

This dissertation consists of two main studies, a few small studies, and design documentation, all aimed at improving rotorcraft control by employing multi-input multi-output (MIMO) command-modelfollowing control as a baseline, together with a selectable (and de-selectable) MIMO high order compensator that augments the baseline. Two methods of MIMO command-model-following control design are compared for rotorcraft flight control. The first, Explicit Model Following (EMF), employs SISO inverse plants with a dynamic decoupling matrix, which is a purely feed-forward approach to inverting the plant. The second is Dynamic Inversion (DI), which involves both feed-forward and feedback path elements to invert the plant. The EMF design is purely linear, while the DI design has some nonlinear elements in vertical rate control. For each of these methods, an architecture is presented that provides angular rate model-following with selectable vertical rate model-following. Implementation challenges of both EMF and DI are covered, and methods of dealing with them are presented. These two MIMO model-following approaches are evaluated regarding (1) fidelity to the command model, and (2) turbulence rejection. Both are found to provide good tracking of commands and reduction of cross coupling. Next, an architecture and design methodology for high order compensator (HOC) augmentation of a baseline controller for rotorcraft is presented. With this architecture, the HOC compensator is selectable and can easily be authority-limited, which might ease certification. Also, the plant for this augmentative MIMO compensator design is a stabilized helicopter system, so good flight test data could be safely gathered for more accurate plant identification. The design methodology is carried out twice on an example helicopter model, once with turbulence rejection as the objective, and once with the additional objective of closely following pilot commands. The turbulence rejection HOC is feedback only (HOC_FB), while the combined objective HOC has both feedback and feedforward elements (HOC_FBFF). The HOC_FB was found to be better at improving turbulence rejection but generally degrades the following of pilot commands. The HOC_FBFF improves turbulence rejection relative to the Baseline controller, but not by as much as HOC_FB. However, HOC_FBFF also generally improves the following of pilot commands. Future work is suggested and facilitated in the areas of DI, MIMO EMF, and HOC augmentation. High frequency dynamics, neglected in the DI design, unexpectedly change the low frequency behavior of the DI-plant system, in addition to the expected change in high frequency dynamics. This dissertation shows why, and suggests a technique for designing a pseudo-command pre-filter that at least partially restores the intended DI-plant dynamics. For EMF, a procedure is presented that avoids use of a reducedorder model, and instead uses a full-order model or even frequency-domain flight test data. With HOC augmentation, future research might investigate the utility of adding an H? constraint to the design objective, which is known as an equal-weighting mixed-norm H2/H infinity design. Because all the formulas in the published literature either require solution of three coupled Riccati Equations (for which there is no readily available tool), or make assumptions that do not fit the present problem, appropriate equalweighting H2/H infinity design formulas are derived which involve two de-coupled Riccati Equations.

A multi-modal approach to assessing recovery in youth athletes following concussion.

PubMed

Reed, Nick; Murphy, James; Dick, Talia; Mah, Katie; Paniccia, Melissa; Verweel, Lee; Dobney, Danielle; Keightley, Michelle

2014-09-25

Concussion is one of the most commonly reported injuries amongst children and youth involved in sport participation. Following a concussion, youth can experience a range of short and long term neurobehavioral symptoms (somatic, cognitive and emotional/behavioral) that can have a significant impact on one's participation in daily activities and pursuits of interest (e.g., school, sports, work, family/social life, etc.). Despite this, there remains a paucity in clinically driven research aimed specifically at exploring concussion within the youth sport population, and more specifically, multi-modal approaches to measuring recovery. This article provides an overview of a novel and multi-modal approach to measuring recovery amongst youth athletes following concussion. The presented approach involves the use of both pre-injury/baseline testing and post-injury/follow-up testing to assess performance across a wide variety of domains (post-concussion symptoms, cognition, balance, strength, agility/motor skills and resting state heart rate variability). The goal of this research is to gain a more objective and accurate understanding of recovery following concussion in youth athletes (ages 10-18 years). Findings from this research can help to inform the development and use of improved approaches to concussion management and rehabilitation specific to the youth sport community.

Wireless Sensor Network Optimization: Multi-Objective Paradigm.

PubMed

Iqbal, Muhammad; Naeem, Muhammad; Anpalagan, Alagan; Ahmed, Ashfaq; Azam, Muhammad

2015-07-20

Optimization problems relating to wireless sensor network planning, design, deployment and operation often give rise to multi-objective optimization formulations where multiple desirable objectives compete with each other and the decision maker has to select one of the tradeoff solutions. These multiple objectives may or may not conflict with each other. Keeping in view the nature of the application, the sensing scenario and input/output of the problem, the type of optimization problem changes. To address different nature of optimization problems relating to wireless sensor network design, deployment, operation, planing and placement, there exist a plethora of optimization solution types. We review and analyze different desirable objectives to show whether they conflict with each other, support each other or they are design dependent. We also present a generic multi-objective optimization problem relating to wireless sensor network which consists of input variables, required output, objectives and constraints. A list of constraints is also presented to give an overview of different constraints which are considered while formulating the optimization problems in wireless sensor networks. Keeping in view the multi facet coverage of this article relating to multi-objective optimization, this will open up new avenues of research in the area of multi-objective optimization relating to wireless sensor networks.

Site systems engineering fiscal year 1999 multi-year work plan (MYWP) update for WBS 1.8.2.2

DOE Office of Scientific and Technical Information (OSTI.GOV)

GRYGIEL, M.L.

1998-10-08

Manage the Site Systems Engineering process to provide a traceable integrated requirements-driven, and technically defensible baseline. Through the Site Integration Group(SIG), Systems Engineering ensures integration of technical activities across all site projects. Systems Engineering's primary interfaces are with the RL Project Managers, the Project Direction Office and with the Project Major Subcontractors, as well as with the Site Planning organization. Systems Implementation: (1) Develops, maintains, and controls the site integrated technical baseline, ensures the Systems Engineering interfaces between projects are documented, and maintain the Site Environmental Management Specification. (2) Develops and uses dynamic simulation models for verification of the baselinemore » and analysis of alternatives. (3) Performs and documents fictional and requirements analyses. (4) Works with projects, technology management, and the SIG to identify and resolve technical issues. (5) Supports technical baseline information for the planning and budgeting of the Accelerated Cleanup Plan, Multi-Year Work Plans, Project Baseline Summaries as well as performance measure reporting. (6) Works with projects to ensure the quality of data in the technical baseline. (7) Develops, maintains and implements the site configuration management system.« less

Evidence for Ordering of Alzheimer’s Disease Biomarkers

PubMed Central

Jack, Clifford R.; Vemuri, Prashanthi; Wiste, Heather J.; Weigand, Stephen D.; Aisen, Paul S.; Trojanowski, John Q.; Shaw, Leslie M.; Bernstein, Matthew A.; Petersen, Ronald C.; Weiner, Michael W.

2012-01-01

Objective To empirically assess the concept that Alzheimer’s disease (AD) biomarkers significantly depart from normality in a temporally ordered manner. Design Validation sample Setting Multi-site, referral centers Patients We studied 401 elderly cognitively normal (CN), Mild Cognitive Impairment (MCI) and AD dementia subjects from the Alzheimer’s Disease Neuroimaging Initiative. We compared the proportions of three AD biomarkers – CSF Aβ42, CSF total tau (t-tau), and hippocampal volume adjusted by intra-cranial volume (HVa) - that were abnormal as cognitive impairment worsened. Cut-points demarcating normal vs. abnormal for each biomarker were established by maximizing diagnostic accuracy in independent autopsy samples. Interventions None Main Outcome measures AD biomarkers Results Within each clinical group in the entire sample (n=401) CSF Aβ42 was abnormal more often than t-tau or HVa. Among the 298 subjects with both baseline and 12 month data, the proportion of subjects with abnormal Aβ42 did not change from baseline to 12 months in any group. The proportion of subjects with abnormal t-tau increased from baseline to 12 months in CN (p=0.05) but not in MCI or dementia. In 209 subjects with abnormal CSF AB42 at baseline, the percent abnormal HVa, but not t-tau, increased from baseline to 12 months in MCI. Conclusions Reduction in CSF Aβ42 denotes a pathophysiological process that significantly departs from normality (i.e., becomes dynamic) early, while t-tau and HVa are biomarkers of downstream pathophysiological processes. T-tau becomes dynamic before HVa, but HVa is more dynamic in the clinically symptomatic MCI and dementia phases of the disease than t-tau. PMID:21825215

Fusion of space-borne multi-baseline and multi-frequency interferometric results based on extended Kalman filter to generate high quality DEMs

NASA Astrophysics Data System (ADS)

Zhang, Xiaojie; Zeng, Qiming; Jiao, Jian; Zhang, Jingfa

2016-01-01

Repeat-pass Interferometric Synthetic Aperture Radar (InSAR) is a technique that can be used to generate DEMs. But the accuracy of InSAR is greatly limited by geometrical distortions, atmospheric effect, and decorrelations, particularly in mountainous areas, such as western China where no high quality DEM has so far been accomplished. Since each of InSAR DEMs generated using data of different frequencies and baselines has their own advantages and disadvantages, it is therefore very potential to overcome some of the limitations of InSAR by fusing Multi-baseline and Multi-frequency Interferometric Results (MMIRs). This paper proposed a fusion method based on Extended Kalman Filter (EKF), which takes the InSAR-derived DEMs as states in prediction step and the flattened interferograms as observations in control step to generate the final fused DEM. Before the fusion, detection of layover and shadow regions, low-coherence regions and regions with large height error is carried out because MMIRs in these regions are believed to be unreliable and thereafter are excluded. The whole processing flow is tested with TerraSAR-X and Envisat ASAR datasets. Finally, the fused DEM is validated with ASTER GDEM and national standard DEM of China. The results demonstrate that the proposed method is effective even in low coherence areas.

The nebula around the post-AGB star 89 Herculis

NASA Astrophysics Data System (ADS)

Bujarrabal, V.; van Winckel, H.; Neri, R.; Alcolea, J.; Castro-Carrizo, A.; Deroo, P.

2007-06-01

Aims:We aim to study the structure of the nebula around the post-AGB, binary star 89 Her. The presence of a rotating disk around this star had been proposed but not been yet confirmed by observations. Methods: We present high-resolution PdBI maps of CO J=2-1 and 1-0. Properties of the nebula are directly derived from the data and model fitting. We also present N-band interferometric data on the extent of the hot dust emission, obtained with the VLTI. Results: Two nebular components are found: (a) an extended hour-glass-like structure, with expansion velocities of 7 km s-1 and a total mass 3× 10-3 M{⊙}, and (b) an unresolved very compact component, smaller than 0.4 arcsec and with a low total velocity dispersion of 5 km s-1. We cannot determine the velocity field in the compact component, but we argue that it can hardly be in expansion, since this would require too recent and too sudden an ejection of mass. On the other hand, assuming that this component is a Keplerian disk, we derive disk properties that are compatible with expectations for such a structure; in particular, the size of the rotating gas disk should be very similar to the extent of the hot dust component from our VLTI data. Assuming that the equator of the extended nebula coincides with the binary orbital plane, we provide new results on the companion star mass and orbit. Based on observations carried out with the IRAM Plateau de Bure Interferometer, as well as on observations of the Belgian Guaranteed time on VISA (ESO). IRAM is supported by INSU/CNRS (France), MPG (Germany) and IGN (Spain).

The 2014 interferometric imaging beauty contest

NASA Astrophysics Data System (ADS)

Monnier, John D.; Berger, Jean-Philippe; Le Bouquin, Jean-Baptiste; Tuthill, Peter G.; Wittkowski, Markus; Grellmann, Rebekka; Müller, André; Renganswany, Sridhar; Hummel, Christian; Hofmann, Karl-Heinz; Schertl, Dieter; Weigelt, Gerd; Young, John; Buscher, David; Sanchez-Bermudez, Joel; Alberdi, Antxon; Schoedel, Rainer; Köhler, Rainer; Soulez, Ferréol; Thiébaut, Éric; Kluska, Jacques; Malbet, Fabien; Duvert, Gilles; Kraus, Stefan; Kloppenborg, Brian K.; Baron, Fabien; de Wit, Willem-Jan; Rivinius, Thomas; Merand, Antoine

2014-07-01

Here we present the results of the 6th biennial optical interferometry imaging beauty contest. Taking advantage of a unique opportunity, the red supergiant VY CMa and the Mira variable R Car were observed in the astronomical H-band with three 4-telescope configurations of the VLTI-AT array using the PIONIER instrument. The community was invited to participate in the subsequent image reconstruction and interpretation phases of the project. Ten groups submitted entries to the beauty contest, and we found reasonable consistency between images obtained from independent workers using quite different algorithms. We also found that significant differences existed between the submitted images, much greater than in past beauty contests that were all based on simulated data. A novel crowd-sourcing" method allowed consensus median images to be constructed, filtering likely artifacts and retaining real features." We definitively detect strong spots on the surfaces of both stars as well as distinct circumstellar shells of emission (likely water/CO) around R Car. In a close contest, Joel Sanchez (IAA-CSIC/Spain) was named the winner of the 2014 interferometric imaging beauty contest. This process has shown that new comers" can use publicly-available imaging software to interpret VLTI/PIONIER imaging data, as long as sufficient observations are taken to have complete uv coverage { a luxury that is often missing. We urge proposers to request adequate observing nights to collect sufficient data for imaging and for time allocation committees to recognise the importance of uv coverage for reliable interpretation of interferometric data. We believe that the result of the proposed broad international project will contribute to inspiring trust in the image reconstruction processes in optical interferometry.

The circumbinary dusty disk of upsilon Sgr revealed by mid-IR interferometric observations with the VLTI/MIDI

NASA Astrophysics Data System (ADS)

Bonneau, D.; Netolický, M.; Chesneau, O.; Harmanec, P.; Koubský, P.; Mourard, D.; Stee, P.

2008-11-01

The first mid-IR interferometric observations of a hydrogen-deficient binary star, υ Sgr, were carried out using the MIDI/VLTI instrument between April 2007 and May 2008. The dusty circumbinary envelope is resolved in the N band (8-13.5 μ m), and has a typical size of 20 x 14 mas. The calibrated fringe visibilities, the mid-IR spectrum and the SED were fitted using models computed with the radiative transfer code MC3D using several mixtures of carbon and silicate dust, in order to determine the geometry and chemical composition of the envelope. The best model we obtain is a geometrically thin and dense disk with an inner radius of R_{in} ≃ 6.0AU and a scale height h_{100} ≃ 3.5 AU. The inclination of the disk is i ≃ 50° and its position angle is PA ≃ 80°. The chemical composition of the dust is approximatelya ratio of 60% of carbon dust and 40% of silicate dust. We constrained for the first time the geometry and the chemistry of the circumbinary dusty envelope of υ Sgr. It is now clear that the components of υ Sgr are massive stars (> 10 M_⊙) and the results are compatible with evolutionary scenario proposed by Delgado & Thomas (1981) of a binary with massive components experiencing several phases of important mass transfer leading to the hydrogen-deficient primary star. However, complementary spectro-interferometric observations in the near infrared and the visible are mandatory to investigate the complex structure of the inner circumstellar environment and directly resolve the stellar components of the υ Sgr system.

Extended envelopes around Galactic Cepheids. IV. T Monocerotis and X Sagittarii from mid-infrared interferometry with VLTI/MIDI

NASA Astrophysics Data System (ADS)

Gallenne, A.; Mérand, A.; Kervella, P.; Chesneau, O.; Breitfelder, J.; Gieren, W.

2013-10-01

Aims: We study the close environment of nearby Cepheids using high spatial resolution observations in the mid-infrared with the VLTI/MIDI instrument, a two-beam interferometric recombiner. Methods: We obtained spectra and visibilities for the classical Cepheids X Sgr and T Mon. We fitted the MIDI measurements, supplemented by B,V,J,H,K literature photometry, with the numerical transfer code DUSTY to determine the dust shell parameters. We used a typical dust composition for circumstellar environments. Results: We detect an extended dusty environment in the spectra and visibilities for both stars, although T Mon might suffer from thermal background contamination. We attribute this to the presence of a circumstellar envelope (CSE) surrounding the Cepheids. This is optically thin for X Sgr (τ0.55 μm = 0.008), while it appears to be thicker for T Mon (τ0.55 μm = 0.15). They are located at about 15-20 stellar radii. Following our previous work, we derived a likely period-excess relation in the VISIR PAH1 filter, f8.6 μm[%]= 0.81(±0.04)P[day]. We argue that the impact of CSEs on the mid-IR period-luminosity (P - L) relation cannot be negligible because they can bias the Cepheid brightness by up to about 30%. For the K-band P - L relation, the CSE contribution seems to be lower (<5%), but the sample needs to be enlarged to firmly conclude that the impact of the CSEs is negligible in this band. Based on observations made with ESO telescopes at Paranal observatory under program ID 082.D-0066Table 3 is only available in electronic form at http://www.aanda.org

Does cataract surgery alleviate poverty? Evidence from a multi-centre intervention study conducted in Kenya, the Philippines and Bangladesh.

PubMed

Kuper, Hannah; Polack, Sarah; Mathenge, Wanjiku; Eusebio, Cristina; Wadud, Zakia; Rashid, Mamunur; Foster, Allen

2010-11-09

Poverty and blindness are believed to be intimately linked, but empirical data supporting this purported relationship are sparse. The objective of this study is to assess whether there is a reduction in poverty after cataract surgery among visually impaired cases. A multi-centre intervention study was conducted in three countries (Kenya, Philippines, Bangladesh). Poverty data (household per capita expenditure--PCE, asset ownership and self-rated wealth) were collected from cases aged ≥50 years who were visually impaired due to cataract (visual acuity<6/24 in the better eye) and age-sex matched controls with normal vision. Cases were offered free/subsidised cataract surgery. Approximately one year later participants were re-interviewed about poverty. 466 cases and 436 controls were examined at both baseline and follow-up (Follow up rate: 78% for cases, 81% for controls), of which 263 cases had undergone cataract surgery ("operated cases"). At baseline, operated cases were poorer compared to controls in terms of PCE (Kenya: $22 versus £35 p = 0.02, Bangladesh: $16 vs $24 p = 0.004, Philippines: $24 vs 32 p = 0.0007), assets and self-rated wealth. By follow-up PCE had increased significantly among operated cases in each of the three settings to the level of controls (Kenya: $30 versus £36 p = 0.49, Bangladesh: $23 vs $23 p = 0.20, Philippines: $45 vs $36 p = 0.68). There were smaller increases in self-rated wealth and no changes in assets. Changes in PCE were apparent in different socio-demographic and ocular groups. The largest PCE increases were apparent among the cases that were poorest at baseline. This study showed that cataract surgery can contribute to poverty alleviation, particularly among the most vulnerable members of society. This study highlights the need for increased provision of cataract surgery to poor people and shows that a focus on blindness may help to alleviate poverty and achieve the Millennium Development Goals.

Application of multi-objective nonlinear optimization technique for coordinated ramp-metering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haj Salem, Habib; Farhi, Nadir; Lebacque, Jean Patrick, E-mail: abib.haj-salem@ifsttar.fr, E-mail: nadir.frahi@ifsttar.fr, E-mail: jean-patrick.lebacque@ifsttar.fr

2015-03-10

This paper aims at developing a multi-objective nonlinear optimization algorithm applied to coordinated motorway ramp metering. The multi-objective function includes two components: traffic and safety. Off-line simulation studies were performed on A4 France Motorway including 4 on-ramps.

Palmer Quest: A Feasible Nuclear Fission "Vision Mission" to the Mars Polar Caps

NASA Technical Reports Server (NTRS)

Carsey, F. D.; Beegle, L. W.; Nakagawa, R.; Elliott, J. O.; Matthews, J. B.; Coleman, M. L.; Hecht, M. H.; Ivaniov, A. B.; Head, J. W.; Milkovich, S.

2005-01-01

We are engaged in a NASA Vision Mission study, called Palmer Quest after the American Antarctic explorer Nathaniel Palmer, to assess the presence of life and evaluate the habitability of the basal domain of the Mars polar caps. We address this goal through four objectives: 1. Determine the presence of amino acids, nutrients, and geochemical heterogeneity in the ice sheet. 2. Quantify and characterize the provenance of the amino acids in Mars ice. 3. Assess the stratification of outcropped units for indications of habitable zones. 4. Determine the accumulation of ice, mineralogic material, and amino acids in Mars ice caps over the present epoch. Because of the defined scientific goal for the vision mission, the Palmer Quest focus is astrobiological; however, the results of the study make us optimistic that aggressive multi-platform in-situ missions that address a wide range of objectives, such as climate change, can be supported by variations of the approach used on this mission. Mission Overview: The Palmer Quest baseline

Shuttle Radar Topography Mission (SRTM) Flight System Design and Operations Overview

NASA Technical Reports Server (NTRS)

Shen, Yuhsyen; Shaffer, Scott J.; Jordan, Rolando L.

2000-01-01

This paper provides an overview of the Shuttle Radar Topography Mission (SRTM), with emphasis on flight system implementation and mission operations from systems engineering perspective. Successfully flown in February, 2000, the SRTM's primary payload consists of several subsystems to form the first spaceborne dual-frequency (C-band and X-band) fixed baseline interferometric synthetic aperture radar (InSAR) system, with the mission objective to acquire data sets over 80% of Earth's landmass for height reconstruction. The paper provides system architecture, unique design features, engineering budgets, design verification, in-flight checkout and data acquisition of the SRTM payload, in particular for the C-band system. Mission operation and post-mission data processing activities are also presented. The complexity of the SRTM as a system, the ambitious mission objective, the demanding requirements and the high interdependency between multi-disciplined subsystems posed many challenges. The engineering experience and the insight thus gained have important implications for future spaceborne interferometric SAR mission design and implementation.

Pearson-Readhead survey from space

NASA Astrophysics Data System (ADS)

Preston, R. A.; Lister, M. L.; Tingay, S. J.; Piner, B. G.; Murphy, D. W.; Jones, D. L.; Meier, D. L.; Pearson, T. J.; Readhead, A. C. S.; Hirabayashi, H.; Kobayashi, H.; Inoue, M.

2001-01-01

We are using the VSOP space VLBI mission to observe a complete sample of Pearson-Readhead survey sources at 4.8 GHz to determine core brightness temperatures and pc-scale jet properties. The Pearson-Readhead sample has been used for extensive ground-based VLBI survey studies, and is ideal for a VSOP survey because the sources are strong, the VSOP u-v coverages are especially good above +35o declination, and multi-epoch ground-based VLBI data and other existing supporting data exceed that of any other sample. To date we have imaged 27 of the 31 objects in our sample. Our preliminary results show that the majority of objects contain strong core components that remain unresolved on baselines of ~30,000 km. The brightness temperatures of several cores significantly exceed 1012 K, which is indicative of highly relativistically beamed emission. We discuss correlations with several other beaming indicators, such as variability and spectral index, that support this scenario. This research was performed in part at the Jet Propulsion Laboratory, California Institute of Technology, under contract to NASA.

Optimal Golomb Ruler Sequences Generation for Optical WDM Systems: A Novel Parallel Hybrid Multi-objective Bat Algorithm

NASA Astrophysics Data System (ADS)

Bansal, Shonak; Singh, Arun Kumar; Gupta, Neena

2017-02-01

In real-life, multi-objective engineering design problems are very tough and time consuming optimization problems due to their high degree of nonlinearities, complexities and inhomogeneity. Nature-inspired based multi-objective optimization algorithms are now becoming popular for solving multi-objective engineering design problems. This paper proposes original multi-objective Bat algorithm (MOBA) and its extended form, namely, novel parallel hybrid multi-objective Bat algorithm (PHMOBA) to generate shortest length Golomb ruler called optimal Golomb ruler (OGR) sequences at a reasonable computation time. The OGRs found their application in optical wavelength division multiplexing (WDM) systems as channel-allocation algorithm to reduce the four-wave mixing (FWM) crosstalk. The performances of both the proposed algorithms to generate OGRs as optical WDM channel-allocation is compared with other existing classical computing and nature-inspired algorithms, including extended quadratic congruence (EQC), search algorithm (SA), genetic algorithms (GAs), biogeography based optimization (BBO) and big bang-big crunch (BB-BC) optimization algorithms. Simulations conclude that the proposed parallel hybrid multi-objective Bat algorithm works efficiently as compared to original multi-objective Bat algorithm and other existing algorithms to generate OGRs for optical WDM systems. The algorithm PHMOBA to generate OGRs, has higher convergence and success rate than original MOBA. The efficiency improvement of proposed PHMOBA to generate OGRs up to 20-marks, in terms of ruler length and total optical channel bandwidth (TBW) is 100 %, whereas for original MOBA is 85 %. Finally the implications for further research are also discussed.

Health of midlife and older adults in China: the role of regional economic development, inequality, and institutional setting.

PubMed

Ding, Xuejie; Billari, Francesco C; Gietel-Basten, Stuart

2017-11-01

To document the association between economic development, income inequality, and health-related public infrastructure, and health outcomes among Chinese adults in midlife and older age. We use a series of multi-level regression models with individual-level baseline data from the China Health and Retirement Longitudinal Survey (CHARLS). Provincial-level data are obtained both from official statistics and from CHARLS itself. Multi-level models are estimated with different subjective and objective health outcomes. Economic growth is associated with better self-rated health, but also with obesity. Better health infrastructure tends to be negatively associated with health outcomes, indicating the likely presence of reverse causality. No supportive evidence is found for the hypothesis that income inequality leads to worse health outcomes. Our study shows that on top of individual characteristics, provincial variations in economic development, income inequality, and health infrastructure are associated with a range of health outcomes for Chinese midlife and older adults. Economic development in China might also bring adverse health outcomes for this age group; as such specific policy responses need to be developed.

Code Calibration Applied to the TCA High-Lift Model in the 14 x 22 Wind Tunnel (Simulation With and Without Model Post-Mount)

NASA Technical Reports Server (NTRS)

Lessard, Wendy B.

1999-01-01

The objective of this study is to calibrate a Navier-Stokes code for the TCA (30/10) baseline configuration (partial span leading edge flaps were deflected at 30 degs. and all the trailing edge flaps were deflected at 10 degs). The computational results for several angles of attack are compared with experimental force, moments, and surface pressures. The code used in this study is CFL3D; mesh sequencing and multi-grid were used to full advantage to accelerate convergence. A multi-grid approach was used similar to that used for the Reference H configuration allowing point-to-point matching across all the trailingedge block interfaces. From past experiences with the Reference H (ie, good force, moment, and pressure comparisons were obtained), it was assumed that the mounting system would produce small effects; hence, it was not initially modeled. However, comparisons of lower surface pressures indicated the post mount significantly influenced the lower surface pressures, so the post geometry was inserted into the existing grid using Chimera (overset grids).

The nutrition-based comprehensive intervention study on childhood obesity in China (NISCOC): a randomised cluster controlled trial.

PubMed

Li, Yanping; Hu, Xiaoqi; Zhang, Qian; Liu, Ailing; Fang, Hongyun; Hao, Linan; Duan, Yifan; Xu, Haiquan; Shang, Xianwen; Ma, Jun; Xu, Guifa; Du, Lin; Li, Ying; Guo, Hongwei; Li, Tingyu; Ma, Guansheng

2010-05-02

Childhood obesity and its related metabolic and psychological abnormalities are becoming serious health problems in China. Effective, feasible and practical interventions should be developed in order to prevent the childhood obesity and its related early onset of clinical cardiovascular diseases. The objective of this paper is to describe the design of a multi-centred random controlled school-based clinical intervention for childhood obesity in China. The secondary objective is to compare the cost-effectiveness of the comprehensive intervention strategy with two other interventions, one only focuses on nutrition education, the other only focuses on physical activity. The study is designed as a multi-centred randomised controlled trial, which included 6 centres located in Beijing, Shanghai, Chongqing, Shandong province, Heilongjiang province and Guangdong province. Both nutrition education (special developed carton style nutrition education handbook) and physical activity intervention (Happy 10 program) will be applied in all intervention schools of 5 cities except Beijing. In Beijing, nutrition education intervention will be applied in 3 schools and physical activity intervention among another 3 schools. A total of 9750 primary students (grade 1 to grade 5, aged 7-13 years) will participate in baseline and intervention measurements, including weight, height, waist circumference, body composition (bioelectrical impendence device), physical fitness, 3 days dietary record, physical activity questionnaire, blood pressure, plasma glucose and plasma lipid profiles. Data concerning investments will be collected in our study, including costs in staff training, intervention materials, teachers and school input and supervising related expenditure. Present study is the first and biggest multi-center comprehensive childhood obesity intervention study in China. Should the study produce comprehensive results, the intervention strategies would justify a national school-based program to prevent childhood obesity in China.

Fixation using alternative implants for the treatment of hip fractures (FAITH): design and rationale for a multi-centre randomized trial comparing sliding hip screws and cancellous screws on revision surgery rates and quality of life in the treatment of femoral neck fractures.

PubMed

2014-06-26

Hip fractures are a common type of fragility fracture that afflict 293,000 Americans (over 5,000 per week) and 35,000 Canadians (over 670 per week) annually. Despite the large population impact the optimal fixation technique for low energy femoral neck fractures remains controversial. The primary objective of the FAITH study is to assess the impact of cancellous screw fixation versus sliding hip screws on rates of revision surgery at 24 months in individuals with femoral neck fractures. The secondary objective is to determine the impact on health-related quality of life, functional outcomes, health state utilities, fracture healing, mortality and fracture-related adverse events. FAITH is a multi-centre, multi-national randomized controlled trial utilizing minimization to determine patient allocation. Surgeons in North America, Europe, Australia, and Asia will recruit a total of at least 1,000 patients with low-energy femoral neck fractures. Using central randomization, patients will be allocated to receive surgical treatment with cancellous screws or a sliding hip screw. Patient outcomes will be assessed at one week (baseline), 10 weeks, 6, 12, 18, and 24 months post initial fixation. We will independently adjudicate revision surgery and complications within 24 months of the initial fixation. Outcome analysis will be performed using a Cox proportional hazards model and likelihood ratio test. This study represents major international efforts to definitively resolve the treatment of low-energy femoral neck fractures. This trial will not only change current Orthopaedic practice, but will also set a benchmark for the conduct of future Orthopaedic trials. The FAITH trial is registered at ClinicalTrials.gov (Identifier NCT00761813).

Solving multi-objective optimization problems in conservation with the reference point method

PubMed Central

Dujardin, Yann; Chadès, Iadine

2018-01-01

Managing the biodiversity extinction crisis requires wise decision-making processes able to account for the limited resources available. In most decision problems in conservation biology, several conflicting objectives have to be taken into account. Most methods used in conservation either provide suboptimal solutions or use strong assumptions about the decision-maker’s preferences. Our paper reviews some of the existing approaches to solve multi-objective decision problems and presents new multi-objective linear programming formulations of two multi-objective optimization problems in conservation, allowing the use of a reference point approach. Reference point approaches solve multi-objective optimization problems by interactively representing the preferences of the decision-maker with a point in the criteria (objectives) space, called the reference point. We modelled and solved the following two problems in conservation: a dynamic multi-species management problem under uncertainty and a spatial allocation resource management problem. Results show that the reference point method outperforms classic methods while illustrating the use of an interactive methodology for solving combinatorial problems with multiple objectives. The method is general and can be adapted to a wide range of ecological combinatorial problems. PMID:29293650

A cluster randomised trial of a school-based intervention to prevent decline in adolescent physical activity levels: study protocol for the ‘Physical Activity 4 Everyone’ trial

PubMed Central

2013-01-01

Background Adolescence is an established period of physical activity decline. Multi-component school-based interventions have the potential to slow the decline in adolescents’ physical activity; however, few interventions have been conducted in schools located in low-income or disadvantaged communities. This study aims to assess the effectiveness of a multi-component school-based intervention in reducing the decline in physical activity among students attending secondary schools located in disadvantaged communities. Methods/Design The cluster randomised trial will be conducted with 10 secondary schools located in selected regions of New South Wales, Australia. The schools will be selected from areas that have a level of socio-economic status that is below the state average. Five schools will be allocated to receive an intervention based on the Health Promoting Schools framework, and will be supported by a part-time physical activity consultant placed in intervention schools who will implement a range of intervention adoption strategies. Study measures will be taken at baseline when students are in Year 7 (12–13 years) and again after 12- and 24-months. The primary outcome, minutes of moderate- to-vigorous- intensity physical activity per day and percentage of time in moderate- to vigorous-intensity physical activity (MVPA), will be objectively assessed using accelerometers (Actigraph GT3x+). Group allocation and intervention delivery will commence after baseline data collection. The intervention will continue during school terms through to 24-month follow-up. Discussion The study will provide evidence regarding the effectiveness of a multi-component school-based intervention that includes an in-school physical activity consultant targeting the physical activity levels of adolescents in disadvantaged Australian secondary schools. Trial registration Australian New Zealand Clinical Trials Registry ACTRN12612000382875. PMID:23336603

Increasing conclusiveness of clinical breath analysis by improved baseline correction of multi capillary column - ion mobility spectrometry (MCC-IMS) data.

PubMed

Szymańska, Ewa; Tinnevelt, Gerjen H; Brodrick, Emma; Williams, Mark; Davies, Antony N; van Manen, Henk-Jan; Buydens, Lutgarde M C

2016-08-05

Current challenges of clinical breath analysis include large data size and non-clinically relevant variations observed in exhaled breath measurements, which should be urgently addressed with competent scientific data tools. In this study, three different baseline correction methods are evaluated within a previously developed data size reduction strategy for multi capillary column - ion mobility spectrometry (MCC-IMS) datasets. Introduced for the first time in breath data analysis, the Top-hat method is presented as the optimum baseline correction method. A refined data size reduction strategy is employed in the analysis of a large breathomic dataset on a healthy and respiratory disease population. New insights into MCC-IMS spectra differences associated with respiratory diseases are provided, demonstrating the additional value of the refined data analysis strategy in clinical breath analysis. Copyright © 2016 Elsevier B.V. All rights reserved.

Wireless Sensor Network Optimization: Multi-Objective Paradigm

PubMed Central

Iqbal, Muhammad; Naeem, Muhammad; Anpalagan, Alagan; Ahmed, Ashfaq; Azam, Muhammad

2015-01-01

Optimization problems relating to wireless sensor network planning, design, deployment and operation often give rise to multi-objective optimization formulations where multiple desirable objectives compete with each other and the decision maker has to select one of the tradeoff solutions. These multiple objectives may or may not conflict with each other. Keeping in view the nature of the application, the sensing scenario and input/output of the problem, the type of optimization problem changes. To address different nature of optimization problems relating to wireless sensor network design, deployment, operation, planing and placement, there exist a plethora of optimization solution types. We review and analyze different desirable objectives to show whether they conflict with each other, support each other or they are design dependent. We also present a generic multi-objective optimization problem relating to wireless sensor network which consists of input variables, required output, objectives and constraints. A list of constraints is also presented to give an overview of different constraints which are considered while formulating the optimization problems in wireless sensor networks. Keeping in view the multi facet coverage of this article relating to multi-objective optimization, this will open up new avenues of research in the area of multi-objective optimization relating to wireless sensor networks. PMID:26205271

Advantages of Task-Specific Multi-Objective Optimisation in Evolutionary Robotics.

PubMed

Trianni, Vito; López-Ibáñez, Manuel

2015-01-01

The application of multi-objective optimisation to evolutionary robotics is receiving increasing attention. A survey of the literature reveals the different possibilities it offers to improve the automatic design of efficient and adaptive robotic systems, and points to the successful demonstrations available for both task-specific and task-agnostic approaches (i.e., with or without reference to the specific design problem to be tackled). However, the advantages of multi-objective approaches over single-objective ones have not been clearly spelled out and experimentally demonstrated. This paper fills this gap for task-specific approaches: starting from well-known results in multi-objective optimisation, we discuss how to tackle commonly recognised problems in evolutionary robotics. In particular, we show that multi-objective optimisation (i) allows evolving a more varied set of behaviours by exploring multiple trade-offs of the objectives to optimise, (ii) supports the evolution of the desired behaviour through the introduction of objectives as proxies, (iii) avoids the premature convergence to local optima possibly introduced by multi-component fitness functions, and (iv) solves the bootstrap problem exploiting ancillary objectives to guide evolution in the early phases. We present an experimental demonstration of these benefits in three different case studies: maze navigation in a single robot domain, flocking in a swarm robotics context, and a strictly collaborative task in collective robotics.

Association of baseline sex hormone levels with baseline and longitudinal changes in waist-to-hip ratio: Multi-Ethnic Study of Atherosclerosis.

PubMed

Vaidya, D; Dobs, A; Gapstur, S M; Golden, S H; Cushman, M; Liu, K; Ouyang, P

2012-12-01

Waist-to-hip ratio (WHR) is strongly associated with prevalent atherosclerosis. We analyzed the associations of baseline serum levels of testosterone (T), estradiol (E2), sex-hormone-binding globulin (SHBG) and dehydroepiandrosterone (DHEA) with WHR in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort. Baseline data was available for 3144 men and 2038 postmenopausal women, who were non-users of hormone therapy, who were 45-84 years of age, and of White, Chinese, Black or Hispanic racial/ethnic groups. Of these, 2708 men and 1678 women also had longitudinal measurements of WHR measured at the second and/or the third study visits (median follow-up 578 days and 1135 days, respectively). In cross-sectional analyses adjusted for age, race and cardiovascular disease risk factors, T was negatively associated with baseline WHR in men, whereas in both sexes, E2 was positively associated and SHBG was negatively associated with WHR (all P<0.001). In longitudinal analyses, further adjusted for follow-up time and baseline WHR, baseline T was negatively associated with WHR at follow-up (P=0.001) in men, whereas in both sexes, E2 was positively associated (P=0.004) and SHBG was negatively associated with WHR (P<0.001). The longitudinal association of E2, but not T, was independent of SHBG. In cross-sectional or longitudinal analyses, there were no associations between DHEA and WHR in either men or women. Sex hormones are associated with WHR at baseline and also during follow-up above and beyond their baseline association. Future research is needed to determine if manipulation of hormones is associated with changes in central obesity.

The flared inner disk of the Herbig Ae star AB Aurigae revealed by VLTI/MIDI in the N-band

NASA Astrophysics Data System (ADS)

di Folco, E.; Dutrey, A.; Chesneau, O.; Wolf, S.; Schegerer, A.; Leinert, Ch.; Lopez, B.

2009-06-01

Aims: We aim at using the long baselines of the VLT Interferometer and the mid-IR combiner MIDI (8-13 μm) to derive the morphology of the protoplanetary disk surrounding the Herbig Ae star AB Aurigae Methods: We present the first N-band analysis of AB Aur performed with a maximum angular resolution of 17 mas (2.5 AU at the Taurus-Auriga distance). We used the radiative transfer code MC3D and a silicate-dominated dust grain mixture to fit the spectral energy distribution (SED), together with the N-band dispersed visibilities (λ / δλ ~ 30) and to constrain the inner-disk spatial structure. Results: The silicate band is prominent in the ~ 300 mas FOV of the MIDI instrument, the emission reaches 70 to 90% of the total flux measured by ISO. The circumstellar emission (CSE) is resolved even at the shortest baselines. The spectrally dispersed visibilities show a steep drop between 8 and 9.5 μm, followed by a plateau between 10 and 13 μm. Our modelling shows that the observed SED and visibilities can be reproduced with a simple passive disk model. For such a weakly inclined disk (i ~ 30 deg), the mid-IR visibilities can directly determine the flaring index, while the scale height can be subsequently and unambiguously derived from the combination of the spectral and interferometric constraints. The modelling yields typical values for the scale height of about 8 AU at a radial distance of 100 AU and a flaring index in the range 1.25-1.30 for the explored range of model input parameters. Conclusions: The radial structure of the circumstellar inner disk around AB Aur is directly determined by MIDI. The radiative transfer modelling demonstrates the powerful synergy of interferometry and spectro-photometry to alleviate the degeneracy, which may hamper determining the disk morphology. Our analysis supports the classification of AB Aur among the flared disks of the first group in the Meeus classification. Based on observations collected at ESO (Paranal Observatory) with the VLT Interferometer - Prog ID: 074.C-552 & 076.C-252.

The close circumstellar environment of the semi-regular S-type star π 1 Gruis

NASA Astrophysics Data System (ADS)

Sacuto, S.; Jorissen, A.; Cruzalèbes, P.; Chesneau, O.; Ohnaka, K.; Quirrenbach, A.; Lopez, B.

2008-05-01

Aims: We study the close circumstellar environment of the nearby S-type star π1 Gruis using high spatial-resolution, mid-infrared observations from the ESO/VLTI. Methods: Spectra and visibilities were obtained with the MIDI interferometer on the VLT Auxiliary Telescopes. The cool M5III giant β Gruis was used as bright primary calibrator, and a dedicated spectro-interferometric study was undertaken to determine its angular diameter accurately. The MIDI measurements were fitted with the 1D numerical radiative transfer code DUSTY to determine the dust shell parameters of π1 Gruis. Taking into account the low spatial extension of the model in the 8-9 μm spectral band for the smallest projected baselines, we consider the possibility of a supplementary molecular shell. Results: The MIDI visibility and phase data are mostly dominated by the spherical 21 mas (694 R_⊙) central star, while the extended dusty environment is over-resolved even with the shortest baselines. No obvious departure from spherical symmetry is found on the milliarcsecond scale. The spectro-interferometric observations are well-fitted by an optically thin (τ_dust<0.01 in the N band) dust shell that is located at about 14 stellar radii with a typical temperature of 700 K and composed of 70% silicate and 30% of amorphous alumina grains. An optically thin (τ_mol<0.1 in the N band) H{2}O + SiO molecular shell extending from the photosphere of the star up to 4.4 stellar radii with a typical temperature of 1000 K is added to the model to improve the fit in the 8-9 μm spectral band. We discuss the probable binary origin of asymmetries as revealed by millimetric observations. Based on observations made with the Very Large Telescope Interferometer at Paranal Observatory under programs 077.D-0294(D/E/F). Reduced visibilities and differential phases are available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/482/561

A close look into the carbon disk at the core of the planetary nebula CPD-56°8032

NASA Astrophysics Data System (ADS)

Chesneau, O.; Collioud, A.; De Marco, O.; Wolf, S.; Lagadec, E.; Zijlstra, A. A.; Rothkopf, A.; Acker, A.; Clayton, G. C.; Lopez, B.

2006-09-01

Aims.We present high spatial resolution observations of the dusty core of the Planetary Nebula with Wolf-Rayet central star CPD-56°8032, for which indications of a compact disk have been found by HST/SITS observations. Methods: .These observations were taken with the mid-infrared interferometer VLTI/MIDI in imaging mode providing a typical 300 mas resolution and in interferometric mode using UT2-UT3 47m baseline providing a typical spatial resolution of 20 mas. We also made use of unpublished HST/ACS images in the F435W and F606W filters. Results: .The visible HST images exhibit a complex multilobal geometry dominated by faint lobes. The farthest structures are located at 7 arcsec from the star. The mid-IR environment of CPD-56°8032 is dominated by a compact source, barely resolved by a single UT telescope in a 8.7 μm filter (Δ λ=1.6~μm, contaminated by PAH emission). The infrared core is almost fully resolved with the three 40-45 m projected baselines ranging from -5° to 51° but smooth oscillating fringes at low level have been detected in spectrally dispersed visibilities. This clear signal is interpreted in terms of a ring structure which would define the bright inner rim of the equatorial disk. Geometric models allowed us to derive the main geometrical parameters of the disk. For instance, a reasonably good fit is reached with an achromatic and elliptical truncated Gaussian with a radius of 97±11 AU, an inclination of 28±7° and a PA for the major axis at 345° ±7°. Furthermore, we performed some radiative transfer modeling aimed at further constraining the geometry and mass content of the disk, by taking into account the MIDI dispersed visibilities, spectra, and the large aperture SED of the source. These models show that the disk is mostly optically thin in the N band and highly flared. As a consequence of the complex flux distribution, an edge-on inclination is not excluded by the data.

The application of multi-baseline digital close-range photogrammetry in three-dimensional imaging and measurement of dental casts

PubMed Central

Li, Zan; Liu, Shan; Tan, Minmin; Song, Jinlin

2017-01-01

Objective To explore a new technique for reconstructing and measuring three-dimensional (3D) models of orthodontic plaster casts using multi-baseline digital close-range photogrammetry (MBDCRP) with a single-lens reflex camera. Study design Thirty sets of orthodontic plaster casts that do not exhibit severe horizontal overlap (>2 mm) between any two teeth were recorded by a single-lens reflex camera with 72 pictures taken in different directions. The 3D models of these casts were reconstructed and measured using the open source software MeshLab. These parameters, including mesio-distal crown diameter, arch width, and arch perimeter, were recorded six times on both the 3D digital models and on plaster casts by two examiners. Statistical analysis was carried out using the Bland–Altman method to measure agreement between the novel method and the traditional calliper method by calculating the differences between mean values. Results The average differences between the measurements of the photogrammetric 3D models and the plaster casts were 0.011–0.402mm. The mean differences between measurements obtained by the photogrammetric 3D models and the dental casts were not significant except for the lower arch perimeter (P>0.05), and all the differences were regarded as clinically acceptable (<0.5 mm). Conclusions Measurements obtained by MBDCRP are compared well with those obtained from plaster casts, indicating that MBDCRP is an alternate way to store and measure dental plaster casts without severe horizontal overlap between any two teeth. PMID:28640827

Update on ORNL TRANSFORM Tool: Simulating Multi-Module Advanced Reactor with End-to-End I&C

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hale, Richard Edward; Fugate, David L.; Cetiner, Sacit M.

2015-05-01

The Small Modular Reactor (SMR) Dynamic System Modeling Tool project is in the fourth year of development. The project is designed to support collaborative modeling and study of various advanced SMR (non-light water cooled reactor) concepts, including the use of multiple coupled reactors at a single site. The focus of this report is the development of a steam generator and drum system model that includes the complex dynamics of typical steam drum systems, the development of instrumentation and controls for the steam generator with drum system model, and the development of multi-reactor module models that reflect the full power reactormore » innovative small module design concept. The objective of the project is to provide a common simulation environment and baseline modeling resources to facilitate rapid development of dynamic advanced reactor models; ensure consistency among research products within the Instrumentation, Controls, and Human-Machine Interface technical area; and leverage cross-cutting capabilities while minimizing duplication of effort. The combined simulation environment and suite of models are identified as the TRANSFORM tool. The critical elements of this effort include (1) defining a standardized, common simulation environment that can be applied throughout the Advanced Reactors Technology program; (2) developing a library of baseline component modules that can be assembled into full plant models using available geometry, design, and thermal-hydraulic data; (3) defining modeling conventions for interconnecting component models; and (4) establishing user interfaces and support tools to facilitate simulation development (i.e., configuration and parameterization), execution, and results display and capture.« less

Effect of electroacupuncture versus pelvic floor muscle training plus solifenacin for moderate and severe mixed urinary incontinence in women: a study protocol.

PubMed

Liu, Baoyan; Wang, Yang; Xu, Huanfang; Chen, Yuelai; Wu, Jiani; Mo, Qian; Liu, Zhishun

2014-08-15

In women with mixed urinary incontinence, pelvic floor muscle training and solifenacin is the recommended conservative treatment, while electroacupuncture is a safe, economical and effective option. In this prospective, multi-center, randomized controlled trial, five hundred women with mixed urinary incontinence, from 10 centers will be randomized to receive either electroacupuncture or pelvic floor muscle training plus solifenacin. Women in the acupuncture group will receive electroacupuncture for 3 sessions per week, over 12 weeks, while women in the control group will receive pelvic floor muscle training plus solifenacin (5 mg once daily) for 36 weeks. The primary outcome measure is the proportion of change in 72-hour incontinence episode frequency from baseline to week 12. The secondary outcome measures include eleven items, including proportion of participants with ≥50% decrease in average 72-h incontinence episode frequency, change from baseline in the amount of urine leakage and proportion of change from baseline in 72-h incontinence episode frequency in week 25-36, and so forth. Statistical analysis will include covariance analysis, nonparametric tests and t tests. The objective of this trial is to compare the efficacy and safety of electroacupuncture versus pelvic floor muscle training plus solifenacin in women with moderate and severe mixed urinary incontinence. ClinicalTrials.gov Identifier: NCT02047032.

Multi-year high-frequency hydrothermal monitoring of selected high-threat Cascade Range volcanoes

NASA Astrophysics Data System (ADS)

Crankshaw, I. M.; Archfield, S. A.; Newman, A. C.; Bergfeld, D.; Clor, L. E.; Spicer, K. R.; Kelly, P. J.; Evans, W. C.; Ingebritsen, S. E.

2018-05-01

From 2009 to 2015 the U.S. Geological Survey (USGS) systematically monitored hydrothermal behavior at selected Cascade Range volcanoes in order to define baseline hydrothermal and geochemical conditions. Gas and water data were collected regularly at 25 sites on 10 of the highest-risk volcanoes in the Cascade Range. These sites include near-summit fumarole groups and springs/streams that show clear evidence of magmatic influence (high 3He/4He ratios and/or large fluxes of magmatic CO2 or heat). Site records consist mainly of hourly temperature and hydrothermal-flux data. Having established baseline conditions during a multiyear quiescent period, the USGS reduced monitoring frequency from 2015 to present. The archived monitoring data are housed at (doi:10.5066/F72N5088). These data (1) are suitable for retrospective comparison with other continuous geophysical monitoring data and (2) will provide context during future episodes of volcanic unrest, such that unrest-related variations at these thoroughly characterized sites will be more clearly recognizable. Relatively high-frequency year-round data are essential to achieve these objectives, because many of the time series reveal significant diurnal, seasonal, and inter-annual variability that would tend to mask unrest signals in the absence of baseline data. Here we characterize normal variability for each site, suggest strategies to detect future volcanic unrest, and explore deviations from background associated with recent unrest.

MultiMetEval: Comparative and Multi-Objective Analysis of Genome-Scale Metabolic Models

PubMed Central

Gevorgyan, Albert; Kierzek, Andrzej M.; Breitling, Rainer; Takano, Eriko

2012-01-01

Comparative metabolic modelling is emerging as a novel field, supported by the development of reliable and standardized approaches for constructing genome-scale metabolic models in high throughput. New software solutions are needed to allow efficient comparative analysis of multiple models in the context of multiple cellular objectives. Here, we present the user-friendly software framework Multi-Metabolic Evaluator (MultiMetEval), built upon SurreyFBA, which allows the user to compose collections of metabolic models that together can be subjected to flux balance analysis. Additionally, MultiMetEval implements functionalities for multi-objective analysis by calculating the Pareto front between two cellular objectives. Using a previously generated dataset of 38 actinobacterial genome-scale metabolic models, we show how these approaches can lead to exciting novel insights. Firstly, after incorporating several pathways for the biosynthesis of natural products into each of these models, comparative flux balance analysis predicted that species like Streptomyces that harbour the highest diversity of secondary metabolite biosynthetic gene clusters in their genomes do not necessarily have the metabolic network topology most suitable for compound overproduction. Secondly, multi-objective analysis of biomass production and natural product biosynthesis in these actinobacteria shows that the well-studied occurrence of discrete metabolic switches during the change of cellular objectives is inherent to their metabolic network architecture. Comparative and multi-objective modelling can lead to insights that could not be obtained by normal flux balance analyses. MultiMetEval provides a powerful platform that makes these analyses straightforward for biologists. Sources and binaries of MultiMetEval are freely available from https://github.com/PiotrZakrzewski/MetEval/downloads. PMID:23272111

Five-year workplace wellness intervention in the NHS.

PubMed

Blake, Holly; Zhou, Dingyuan; Batt, Mark E

2013-09-01

Poor health and well-being has been observed among NHS staff and has become a key focus in current public health policy. The objective of this study was to deliver and evaluate a five-year employee wellness programme aimed at improving the health and well-being of employees in a large NHS workplace. A theory-driven multi-level ecological workplace wellness intervention was delivered including health campaigns, provision of facilities and health-promotion activities to encourage employees to make healthy lifestyle choices and sustained behaviour changes. An employee questionnaire survey was distributed at baseline (n = 1,452) and at five years (n = 1,134), including measures of physical activity, BMI, diet, self-efficacy, social support, perceived general health and mood, smoking behaviours, self-reported sickness absence, perceived work performance and job satisfaction. Samples were comparable at baseline and follow-up. At five years, significantly more respondents actively travelled (by walking or cycling both to work and for non-work trips) and more were active while at work. Significantly more respondents met current recommendations for physical activity at five years than at baseline. Fewer employers reported 'lack of time' as a barrier to being physically active following the intervention. Significantly lower sickness absence, greater job satisfaction and greater organisational commitment was reported at five years than at baseline. Improvements in health behaviours, reductions in sickness absence and improvements in job satisfaction and organisational commitment were observed following five years of a workplace wellness intervention for NHS employees. These findings suggest that health-promoting programmes should be embedded within NHS infrastructure.

VizieR Online Data Catalog: Disk of {upsilon} Sgr (Netolicky+, 2009)

NASA Astrophysics Data System (ADS)

Netolicky, M.; Bonneau, D.; Chesneau, O.; Harmanec, P.; Koubsky, P.; Mourard, D.; Stee, P.

2010-01-01

The aim of this paper is to determine the properties of the dusty environment of the hydrogen-deficient binary system upsilon Sgr, whose binary properties and other characteristics are poorly known. We obtained the first mid-IR interferometric observations of upsilon Sgr using the instrument MIDI of the VLTI used with different pairs of 1.8m and 8m telescopes. The calibrated visibilities, the N band spectrum, and the SED were compared with disk models computed with the MC3D code to determine the geometry and chemical composition of the envelope. ************************************************************************** * * * Sorry, but the author(s) never supplied the tabular material * * announced in the paper * * * **************************************************************************

A Data Exchange Standard for Optical (Visible/IR) Interferometry

NASA Astrophysics Data System (ADS)

Pauls, T. A.; Young, J. S.; Cotton, W. D.; Monnier, J. D.

2005-11-01

This paper describes the OI (Optical Interferometry) Exchange Format, a standard for exchanging calibrated data from optical (visible/infrared) stellar interferometers. The standard is based on the Flexible Image Transport System (FITS) and supports the storage of optical interferometric observables, including squared visibility and closure phase-data products not included in radio interferometry standards such as UV-FITS. The format has already gained the support of most currently operating optical interferometer projects, including COAST, NPOI, IOTA, CHARA, VLTI, PTI, and the Keck Interferometer, and is endorsed by the IAU Working Group on Optical Interferometry. Software is available for reading, writing, and the merging of OI Exchange Format files.

Why is the VLT Very Efficient?

NASA Astrophysics Data System (ADS)

Comerón, F.

2009-09-01

The operations model of the ESO Very Large Telescope (VLT) heavily relies on a full-scale implementation of Service Mode observing. In this contribution we review the main features of ESO's approach to Service Mode at the VLT, we outline the advantages offered by this mode, and the challenges faced when implementing it given the wide diversity of instrumentation and instrument modes currently available at the VLT and the VLT Interferometer (VLTI). We give special emphasis to the part of this challenge directly derived from the evolution of the atmospheric conditions, which drive the short-term scheduling of the different scientific programmes competing for the available time.

Structural damage detection-oriented multi-type sensor placement with multi-objective optimization

NASA Astrophysics Data System (ADS)

Lin, Jian-Fu; Xu, You-Lin; Law, Siu-Seong

2018-05-01

A structural damage detection-oriented multi-type sensor placement method with multi-objective optimization is developed in this study. The multi-type response covariance sensitivity-based damage detection method is first introduced. Two objective functions for optimal sensor placement are then introduced in terms of the response covariance sensitivity and the response independence. The multi-objective optimization problem is formed by using the two objective functions, and the non-dominated sorting genetic algorithm (NSGA)-II is adopted to find the solution for the optimal multi-type sensor placement to achieve the best structural damage detection. The proposed method is finally applied to a nine-bay three-dimensional frame structure. Numerical results show that the optimal multi-type sensor placement determined by the proposed method can avoid redundant sensors and provide satisfactory results for structural damage detection. The restriction on the number of each type of sensors in the optimization can reduce the searching space in the optimization to make the proposed method more effective. Moreover, how to select a most optimal sensor placement from the Pareto solutions via the utility function and the knee point method is demonstrated in the case study.

Multiple utility constrained multi-objective programs using Bayesian theory

NASA Astrophysics Data System (ADS)

Abbasian, Pooneh; Mahdavi-Amiri, Nezam; Fazlollahtabar, Hamed

2018-03-01

A utility function is an important tool for representing a DM's preference. We adjoin utility functions to multi-objective optimization problems. In current studies, usually one utility function is used for each objective function. Situations may arise for a goal to have multiple utility functions. Here, we consider a constrained multi-objective problem with each objective having multiple utility functions. We induce the probability of the utilities for each objective function using Bayesian theory. Illustrative examples considering dependence and independence of variables are worked through to demonstrate the usefulness of the proposed model.

Irrigation water allocation optimization using multi-objective evolutionary algorithm (MOEA) - a review

NASA Astrophysics Data System (ADS)

Fanuel, Ibrahim Mwita; Mushi, Allen; Kajunguri, Damian

2018-03-01

This paper analyzes more than 40 papers with a restricted area of application of Multi-Objective Genetic Algorithm, Non-Dominated Sorting Genetic Algorithm-II and Multi-Objective Differential Evolution (MODE) to solve the multi-objective problem in agricultural water management. The paper focused on different application aspects which include water allocation, irrigation planning, crop pattern and allocation of available land. The performance and results of these techniques are discussed. The review finds that there is a potential to use MODE to analyzed the multi-objective problem, the application is more significance due to its advantage of being simple and powerful technique than any Evolutionary Algorithm. The paper concludes with the hopeful new trend of research that demand effective use of MODE; inclusion of benefits derived from farm byproducts and production costs into the model.

Multi-site pain and working conditions as predictors of work ability in a 4-year follow-up among food industry employees.

PubMed

Neupane, S; Virtanen, P; Leino-Arjas, P; Miranda, H; Siukola, A; Nygård, C-H

2013-03-01

We investigated the separate and joint effects of multi-site musculoskeletal pain and physical and psychosocial exposures at work on future work ability. A survey was conducted among employees of a Finnish food industry company in 2005 (n = 1201) and a follow-up survey in 2009 (n = 734). Information on self-assessed work ability (current work ability on a scale from 0 to 10; 7 = poor work ability), multi-site musculoskeletal pain (pain in at least two anatomical areas of four), leisure-time physical activity, body mass index and physical and psychosocial exposures was obtained by questionnaire. The separate and joint effects of multi-site pain and work exposures on work ability at follow-up, among subjects with good work ability at baseline, were assessed by logistic regression, and p-values for the interaction derived. Compared with subjects with neither multi-site pain nor adverse work exposure, multi-site pain at baseline increased the risk of poor work ability at follow-up, allowing for age, gender, occupational class, body mass index and leisure-time physical activity. The separate effects of the work exposures on work ability were somewhat smaller than those of multi-site pain. Multi-site pain had an interactive effect with work environment and awkward postures, such that no association of multi-site pain with poor work ability was seen when work environment was poor or awkward postures present. The decline in work ability connected with multi-site pain was not increased by exposure to adverse physical or psychosocial factors at work. © 2012 European Federation of International Association for the Study of Pain Chapters.

Algorithmic and user study of an autocompletion algorithm on a large medical vocabulary.

PubMed

Sevenster, Merlijn; van Ommering, Rob; Qian, Yuechen

2012-02-01

Autocompletion supports human-computer interaction in software applications that let users enter textual data. We will be inspired by the use case in which medical professionals enter ontology concepts, catering the ongoing demand for structured and standardized data in medicine. Goal is to give an algorithmic analysis of one particular autocompletion algorithm, called multi-prefix matching algorithm, which suggests terms whose words' prefixes contain all words in the string typed by the user, e.g., in this sense, opt ner me matches optic nerve meningioma. Second we aim to investigate how well it supports users entering concepts from a large and comprehensive medical vocabulary (snomed ct). We give a concise description of the multi-prefix algorithm, and sketch how it can be optimized to meet required response time. Performance will be compared to a baseline algorithm, which gives suggestions that extend the string typed by the user to the right, e.g. optic nerve m gives optic nerve meningioma, but opt ner me does not. We conduct a user experiment in which 12 participants are invited to complete 40 snomed ct terms with the baseline algorithm and another set of 40 snomed ct terms with the multi-prefix algorithm. Our results show that users need significantly fewer keystrokes when supported by the multi-prefix algorithm than when supported by the baseline algorithm. The proposed algorithm is a competitive candidate for searching and retrieving terms from a large medical ontology. Copyright © 2011 Elsevier Inc. All rights reserved.

Advantages of Task-Specific Multi-Objective Optimisation in Evolutionary Robotics

PubMed Central

Trianni, Vito; López-Ibáñez, Manuel

2015-01-01

The application of multi-objective optimisation to evolutionary robotics is receiving increasing attention. A survey of the literature reveals the different possibilities it offers to improve the automatic design of efficient and adaptive robotic systems, and points to the successful demonstrations available for both task-specific and task-agnostic approaches (i.e., with or without reference to the specific design problem to be tackled). However, the advantages of multi-objective approaches over single-objective ones have not been clearly spelled out and experimentally demonstrated. This paper fills this gap for task-specific approaches: starting from well-known results in multi-objective optimisation, we discuss how to tackle commonly recognised problems in evolutionary robotics. In particular, we show that multi-objective optimisation (i) allows evolving a more varied set of behaviours by exploring multiple trade-offs of the objectives to optimise, (ii) supports the evolution of the desired behaviour through the introduction of objectives as proxies, (iii) avoids the premature convergence to local optima possibly introduced by multi-component fitness functions, and (iv) solves the bootstrap problem exploiting ancillary objectives to guide evolution in the early phases. We present an experimental demonstration of these benefits in three different case studies: maze navigation in a single robot domain, flocking in a swarm robotics context, and a strictly collaborative task in collective robotics. PMID:26295151

Effect of Supplementation with Zinc and Other Micronutrients on Malaria in Tanzanian Children: A Randomised Trial

PubMed Central

Veenemans, Jacobien; Milligan, Paul; Prentice, Andrew M.; Schouten, Laura R. A.; Inja, Nienke; van der Heijden, Aafke C.; de Boer, Linsey C. C.; Jansen, Esther J. S.; Koopmans, Anna E.; Enthoven, Wendy T. M.; Kraaijenhagen, Rob J.; Demir, Ayse Y.; Uges, Donald R. A.; Mbugi, Erasto V.; Savelkoul, Huub F. J.; Verhoef, Hans

2011-01-01

Background It is uncertain to what extent oral supplementation with zinc can reduce episodes of malaria in endemic areas. Protection may depend on other nutrients. We measured the effect of supplementation with zinc and other nutrients on malaria rates. Methods and Findings In a 2×2 factorial trial, 612 rural Tanzanian children aged 6–60 months in an area with intense malaria transmission and with height-for-age z-score≤−1.5 SD were randomized to receive daily oral supplementation with either zinc alone (10 mg), multi-nutrients without zinc, multi-nutrients with zinc, or placebo. Intervention group was indicated by colour code, but neither participants, researchers, nor field staff knew who received what intervention. Those with Plasmodium infection at baseline were treated with artemether-lumefantrine. The primary outcome, an episode of malaria, was assessed among children reported sick at a primary care clinic, and pre-defined as current Plasmodium infection with an inflammatory response, shown by axillary temperature ≥37.5°C or whole blood C-reactive protein concentration ≥8 mg/L. Nutritional indicators were assessed at baseline and at 251 days (median; 95% reference range: 191–296 days). In the primary intention-to-treat analysis, we adjusted for pre-specified baseline factors, using Cox regression models that accounted for multiple episodes per child. 592 children completed the study. The primary analysis included 1,572 malaria episodes during 526 child-years of observation (median follow-up: 331 days). Malaria incidence in groups receiving zinc, multi-nutrients without zinc, multi-nutrients with zinc and placebo was 2.89/child-year, 2.95/child-year, 3.26/child-year, and 2.87/child-year, respectively. There was no evidence that multi-nutrients influenced the effect of zinc (or vice versa). Neither zinc nor multi-nutrients influenced malaria rates (marginal analysis; adjusted HR, 95% CI: 1.04, 0.93–1.18 and 1.10, 0.97–1.24 respectively). The prevalence of zinc deficiency (plasma zinc concentration <9.9 µmol/L) was high at baseline (67% overall; 60% in those without inflammation) and strongly reduced by zinc supplementation. Conclusions We found no evidence from this trial that zinc supplementation protected against malaria. Trial Registration ClinicalTrials.gov NCT00623857 Please see later in the article for the Editors' Summary. PMID:22131908

Cross-Domain Multi-View Object Retrieval via Multi-Scale Topic Models.

PubMed

Hong, Richang; Hu, Zhenzhen; Wang, Ruxin; Wang, Meng; Tao, Dacheng

2016-09-27

The increasing number of 3D objects in various applications has increased the requirement for effective and efficient 3D object retrieval methods, which attracted extensive research efforts in recent years. Existing works mainly focus on how to extract features and conduct object matching. With the increasing applications, 3D objects come from different areas. In such circumstances, how to conduct object retrieval becomes more important. To address this issue, we propose a multi-view object retrieval method using multi-scale topic models in this paper. In our method, multiple views are first extracted from each object, and then the dense visual features are extracted to represent each view. To represent the 3D object, multi-scale topic models are employed to extract the hidden relationship among these features with respected to varied topic numbers in the topic model. In this way, each object can be represented by a set of bag of topics. To compare the objects, we first conduct topic clustering for the basic topics from two datasets, and then generate the common topic dictionary for new representation. Then, the two objects can be aligned to the same common feature space for comparison. To evaluate the performance of the proposed method, experiments are conducted on two datasets. The 3D object retrieval experimental results and comparison with existing methods demonstrate the effectiveness of the proposed method.

Depression-Specific Outcomes After Treatment of Chronic Rhinosinusitis

PubMed Central

Schlosser, Rodney J.; Hyer, J. Madison; Smith, Timothy L.; Mace, Jess C.; Cortese, Bernadette M.; Uhde, Thomas W.; Rudmik, Luke; Soler, Zachary M.

2016-01-01

IMPORTANCE Depression is frequently undiagnosed in patients with chronic rhinosinusitis (CRS) and affects quality of life, productivity, and health care use. OBJECTIVE To examine depression-specific outcomes after medical or surgical treatment of CRS. DESIGN, SETTING, AND PARTICIPANTS A multi-institutional, prospective study of patients with refractory CRS treated at tertiary academic rhinology centers was performed from March 1, 2011, to November 1, 2015. Data analysis was performed from October 1, 2015, to November 1, 2015. INTERVENTIONS Patients self-selected to undergo continued medical management or endoscopic sinus surgery for refractory CRS. MAIN OUTCOMES AND MEASURES Patients completed the 22-item Sinonasal Outcome Test (SNOT22), Rhinosinusitis Disability Index (RSDI), Pittsburgh Sleep Quality Index (PSQI), and missed productivity and medication use questionnaires before and at least 6 months after treatment. Computed tomography and endoscopy scoring were performed with reviewers masked to patient-reported data. Depression-specific outcomes were recorded using the 2-item Patient Health Questionnaire (PHQ2). RESULTS Baseline data were available on 685 patients, with 167 (24.4%) having depression according to the PHQ2 scores. The mean (SD) age of the patients was 50.5 (15.0) years, and 332 (48.4%) were male. Revision surgery status was the only baseline factor associated with depression (53.9%vs 38.0%, P < .001). Patients with depression had worse baseline SNOT22 (mean, 64.5 vs 47.6), PSQI (mean, 12.8 vs 8.4), productivity (mean, 22.8 vs 5.2 days missed), and medication use scores for oral antibiotics (mean, 23.8 vs 14.8) and oral corticosteroids (mean, 17.8 vs 9.9) (P < .001 for all). Medical and surgical treatments had similar outcomes for patients with depression with mean improvement in the PHQ2 scores from 3.96 to 1.91 (P < .001), and 110 of 167 patients (65.9%) categorized as having depression at baseline were categorized as not having depression after treatment. Improvements in the PHQ2 scores were associated with improvements in the SNOT22, PSQI, oral antibiotic use, and productivity scores (P ≤ .001 for all). CONCLUSIONS AND RELEVANCE Depression is a common comorbidity in patients with CRS and affects numerous quality-of-life and health care outcomes. There are few objective baseline factors to aid physicians in identifying depression in patients with CRS. Medical and surgical treatments for CRS improve depression and related clinical outcomes. PMID:26967171

VLTI/AMBER observations of cold giant stars: atmospheric structures and fundamental parameters

NASA Astrophysics Data System (ADS)

Arroyo-Torres, B.; Martí-Vidal, I.; Marcaide, J. M.; Wittkowski, M.; Guirado, J. C.; Hauschildt, P. H.; Quirrenbach, A.; Fabregat, J.

2014-06-01

Aims: The main goal of this research is to determine the angular size and the atmospheric structures of cool giant stars (ɛ Oct, β Peg, NU Pav, ψ Peg, and γ Hya) and to compare them with hydrostatic stellar model atmospheres, to estimate the fundamental parameters, and to obtain a better understanding of the circumstellar environment. Methods: We conducted spectro-interferometric observations of ɛ Oct, β Peg, NU Pav, and ψ Peg in the near-infrared K band (2.13-2.47 μm), and γ Hya (1.9-2.47 μm) with the VLTI/AMBER instrument at medium spectral resolution (~1500). To obtain the fundamental parameters, we compared our data with hydrostatic atmosphere models (PHOENIX). Results: We estimated the Rosseland angular diameters of ɛ Oct, β Peg, NU Pav, ψ Peg, and γ Hya to be 11.66±1.50 mas, 16.87±1.00 mas, 13.03±1.75 mas, 6.31±0.35 mas, and 3.78±0.65 mas, respectively. Together with distances and bolometric fluxes (obtained from the literature), we estimated radii, effective temperatures, and luminosities of our targets. In the β Peg visibility, we observed a molecular layer of CO with a size similar to that modeled with PHOENIX. However, there is an additional slope in absorption starting around 2.3 μm. This slope is possibly due to a shell of H2O that is not modeled with PHOENIX (the size of the layer increases to about 5% with respect to the near-continuum level). The visibility of ψ Peg shows a low increase in the CO bands, compatible with the modeling of the PHOENIX model. The visibility data of ɛ Oct, NU Pav, and γ Hya show no increase in molecular bands. Conclusions: The spectra and visibilities predicted by the PHOENIX atmospheres agree with the spectra and the visibilities observed in our stars (except for β Peg). This indicates that the opacity of the molecular bands is adequately included in the model, and the atmospheres of our targets have an extension similar to the modeled atmospheres. The atmosphere of β Peg is more extended than that predicted by the model. The role of pulsations, if relevant in other cases and unmodeled by PHOENIX, therefore seems negligible for the atmospheric structures of our sample. The targets are located close to the red limits of the evolutionary tracks of the STAREVOL model, corresponding to masses between 1 M⊙ and 3 M⊙. The STAREVOL model fits the position of our stars in the Hertzsprung-Russell (HR) diagram better than the Ekström model does. STAREVOL includes thermohaline mixing, unlike the Ekström model, and complements the latter for intermediate-mass stars. Based on observations made with the VLT Interferometer (VLTI) at Paranal Observatory under programme ID 089.D-0801.Figures 2-4 are available in electronic form at http://www.aanda.org

Sculpting the disk around T Chamaeleontis: an interferometric view

NASA Astrophysics Data System (ADS)

Olofsson, J.; Benisty, M.; Le Bouquin, J.-B.; Berger, J.-P.; Lacour, S.; Ménard, F.; Henning, Th.; Crida, A.; Burtscher, L.; Meeus, G.; Ratzka, T.; Pinte, C.; Augereau, J.-C.; Malbet, F.; Lazareff, B.; Traub, W.

2013-04-01

Context. Circumstellar disks are believed to be the birthplace of planets and are expected to dissipate on a timescale of a few Myr. The processes responsible for the removal of the dust and gas will strongly modify the radial distribution of the circumstellar matter and consequently the spectral energy distribution. In particular, a young planet will open a gap, resulting in an inner disk dominating the near-IR emission and an outer disk emitting mostly in the far-infrared. Aims: We analyze a full set of data involving new near-infrared data obtained with the 4-telescope combiner (VLTI/PIONIER), new mid-infrared interferometric VLTI/MIDI data, literature photometric and archival data from VLT/NaCo/SAM to constrain the structure of the transition disk around T Cha. Methods: After a preliminary analysis with a simple geometric model, we used the MCFOST radiative transfer code to simultaneously model the SED and the interferometric observables from raytraced images in the H-, L'-, and N-bands. Results: We find that the dust responsible for the strong emission in excess in the near-IR must have a narrow temperature distribution with a maximum close to the silicate sublimation temperature. This translates into a narrow inner dusty disk (0.07-0.11 AU), with a significant height (H/r ~ 0.2) to increase the geometric surface illuminated by the central star. We find that the outer disk starts at about 12 AU and is partially resolved by the PIONIER, SAM, and MIDI instruments. We discuss the possibility of a self-shadowed inner disk, which can extend to distances of several AU. Finally, we show that the SAM closure phases, interpreted as the signature of a candidate companion, may actually trace the asymmetry generated by forward scattering by dust grains in the upper layers of the outer disk. These observations help constrain the inclination and position angle of the disk to about + 58° and - 70°, respectively. Conclusions: The circumstellar environment of T Cha appears to be best described by two disks spatially separated by a large gap. The presence of matter (dust or gas) inside the gap is, however, difficult to assess with present-day observations. Our model suggests the outer disk contaminates the interferometric signature of any potential companion that could be responsible for the gap opening, and such a companion still has to be unambiguously detected. We stress the difficulty to observe point sources in bright massive disks, and the consequent need to account for disk asymmetries (e.g. anisotropic scattering) in model-dependent search for companions. Based on PIONIER observations collected at the VLTI (European Southern Observatory, Paranal, Chile) with programs 087.C-0702(B), 087.C-0709(A), 089.C-0537(A), 083.C-0883(C & D), and 083.C-0295(A & B).

Solving intuitionistic fuzzy multi-objective nonlinear programming problem

NASA Astrophysics Data System (ADS)

Anuradha, D.; Sobana, V. E.

2017-11-01

This paper presents intuitionistic fuzzy multi-objective nonlinear programming problem (IFMONLPP). All the coefficients of the multi-objective nonlinear programming problem (MONLPP) and the constraints are taken to be intuitionistic fuzzy numbers (IFN). The IFMONLPP has been transformed into crisp one and solved by using Kuhn-Tucker condition. Numerical example is provided to illustrate the approach.

Multi-wavelength spectrophotometric analysis for detection of xanthochromia in cerebrospinal fluid and accuracy for the diagnosis of subarachnoid hemorrhage.

PubMed

Smith, Andrew; Wu, Alan H B; Lynch, Kara L; Ko, Nerissa; Grenache, David G

2013-09-23

Cerebrospinal fluid (CSF) was examined for bilirubin, an important indicator for diagnosis of subarachnoid hemorrhage (SAH). A multi-wavelength (340, 415, and 460 nm) spectrophotometric assay was developed for the quantitative measurement of bilirubin in CSF, enabling the mathematical correction for absorbance of hemoglobin and proteins. Bilirubin and hemoglobin results were correlated to HPLC and a standard colorimetric assay, respectively. A subset of samples was sent for an absorbance reading at 450 nm following baseline correction. The multi-wavelength bilirubin assay was validated on 70 patients with confirmed SAH and 70 patients with neurologic symptoms who ruled out for SAH. The multi-wavelength spectrophometric assay demonstrated no interferences due to proteins (albumin) up to 30 g/l or oxyhemoglobin up to 260 mg/l. The assay limit of detection was 0.2 mg/l, linear to 20 mg/l, and CVs ranged from 1 to 6% at bilirubin concentrations of 0.84 and 2.1mg/l. The spectrophotometric assay correlated to HPLC and the colorimetric assay for bilirubin and hemoglobin, respectively. Results also correlated to the absorbance method (with removal of samples with high hemoglobin and proteins). The area under the ROC curve for diagnosis of SAH was 0.971 and 0.954 for the HPLC and spectrophotometric assay, respectively. At a cutoff of 0.2mg/l, the clinical specificity was 100% for both assays, and the clinical sensitivity was 94.3% and 88.6% for SAH for the HPLC and spectrophotometric asays, respectively. The multi-wavelength spectrophotometric assay is an objective alternative to visual inspection, HPLC, and absorbance for CSF bilirubin. Copyright © 2013 Elsevier B.V. All rights reserved.

SU-D-213-03: Towards An Optimized 3D Scintillation Dosimetry Tool for Quality Assurance of Dynamic Radiotherapy Techniques

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rilling, M; Centre de Recherche sur le Cancer, Hôtel-Dieu de Québec, Quebec City, QC; Département de radio-oncologie, CHU de Québec, Quebec City, QC

2015-06-15

Purpose: The purpose of this work is to simulate a multi-focus plenoptic camera used as the measuring device in a real-time three-dimensional scintillation dosimeter. Simulating and optimizing this realistic optical system will bridge the technological gap between concept validation and a clinically viable tool that can provide highly efficient, accurate and precise measurements for dynamic radiotherapy techniques. Methods: The experimental prototype, previously developed for proof of concept purposes, uses an off-the-shelf multi-focus plenoptic camera. With an array of interleaved microlenses of different focal lengths, this camera records spatial and angular information of light emitted by a plastic scintillator volume. Themore » three distinct microlens focal lengths were determined experimentally for use as baseline parameters by measuring image-to-object magnification for different distances in object space. A simulated plenoptic system was implemented using the non-sequential ray tracing software Zemax: this tool allows complete simulation of multiple optical paths by modeling interactions at interfaces such as scatter, diffraction, reflection and refraction. The active sensor was modeled based on the camera manufacturer specifications by a 2048×2048, 5 µm-pixel pitch sensor. Planar light sources, simulating the plastic scintillator volume, were employed for ray tracing simulations. Results: The microlens focal lengths were determined to be 384, 327 and 290 µm. A realistic multi-focus plenoptic system, with independently defined and optimizable specifications, was fully simulated. A f/2.9 and 54 mm-focal length Double Gauss objective was modeled as the system’s main lens. A three-focal length hexagonal microlens array of 250-µm thickness was designed, acting as an image-relay system between the main lens and sensor. Conclusion: Simulation of a fully modeled multi-focus plenoptic camera enables the decoupled optimization of the main lens and microlens specifications. This work leads the way to improving the 3D dosimeter’s achievable resolution, efficiency and build for providing a quality assurance tool fully meeting clinical needs. M.R. is financially supported by a Master’s Canada Graduate Scholarship from the NSERC. This research is also supported by the NSERC Industrial Research Chair in Optical Design.« less

Single and Multiple Object Tracking Using a Multi-Feature Joint Sparse Representation.

PubMed

Hu, Weiming; Li, Wei; Zhang, Xiaoqin; Maybank, Stephen

2015-04-01

In this paper, we propose a tracking algorithm based on a multi-feature joint sparse representation. The templates for the sparse representation can include pixel values, textures, and edges. In the multi-feature joint optimization, noise or occlusion is dealt with using a set of trivial templates. A sparse weight constraint is introduced to dynamically select the relevant templates from the full set of templates. A variance ratio measure is adopted to adaptively adjust the weights of different features. The multi-feature template set is updated adaptively. We further propose an algorithm for tracking multi-objects with occlusion handling based on the multi-feature joint sparse reconstruction. The observation model based on sparse reconstruction automatically focuses on the visible parts of an occluded object by using the information in the trivial templates. The multi-object tracking is simplified into a joint Bayesian inference. The experimental results show the superiority of our algorithm over several state-of-the-art tracking algorithms.

Optimal design of groundwater remediation system using a probabilistic multi-objective fast harmony search algorithm under uncertainty

NASA Astrophysics Data System (ADS)

Luo, Qiankun; Wu, Jianfeng; Yang, Yun; Qian, Jiazhong; Wu, Jichun

2014-11-01

This study develops a new probabilistic multi-objective fast harmony search algorithm (PMOFHS) for optimal design of groundwater remediation systems under uncertainty associated with the hydraulic conductivity (K) of aquifers. The PMOFHS integrates the previously developed deterministic multi-objective optimization method, namely multi-objective fast harmony search algorithm (MOFHS) with a probabilistic sorting technique to search for Pareto-optimal solutions to multi-objective optimization problems in a noisy hydrogeological environment arising from insufficient K data. The PMOFHS is then coupled with the commonly used flow and transport codes, MODFLOW and MT3DMS, to identify the optimal design of groundwater remediation systems for a two-dimensional hypothetical test problem and a three-dimensional Indiana field application involving two objectives: (i) minimization of the total remediation cost through the engineering planning horizon, and (ii) minimization of the mass remaining in the aquifer at the end of the operational period, whereby the pump-and-treat (PAT) technology is used to clean up contaminated groundwater. Also, Monte Carlo (MC) analysis is employed to evaluate the effectiveness of the proposed methodology. Comprehensive analysis indicates that the proposed PMOFHS can find Pareto-optimal solutions with low variability and high reliability and is a potentially effective tool for optimizing multi-objective groundwater remediation problems under uncertainty.

A simple method to achieve full-field and real-scale reconstruction using a movable stereo rig

NASA Astrophysics Data System (ADS)

Gu, Feifei; Zhao, Hong; Song, Zhan; Tang, Suming

2018-06-01

This paper introduces a simple method to achieve full-field and real-scale reconstruction using a movable binocular vision system (MBVS). The MBVS is composed of two cameras, one is called the tracking camera, and the other is called the working camera. The tracking camera is used for tracking the positions of the MBVS and the working camera is used for the 3D reconstruction task. The MBVS has several advantages compared with a single moving camera or multi-camera networks. Firstly, the MBVS could recover the real-scale-depth-information from the captured image sequences without using auxiliary objects whose geometry or motion should be precisely known. Secondly, the removability of the system could guarantee appropriate baselines to supply more robust point correspondences. Additionally, using one camera could avoid the drawback which exists in multi-camera networks, that the variability of a cameras’ parameters and performance could significantly affect the accuracy and robustness of the feature extraction and stereo matching methods. The proposed framework consists of local reconstruction and initial pose estimation of the MBVS based on transferable features, followed by overall optimization and accurate integration of multi-view 3D reconstruction data. The whole process requires no information other than the input images. The framework has been verified with real data, and very good results have been obtained.

Improved NSGA model for multi objective operation scheduling and its evaluation

NASA Astrophysics Data System (ADS)

Li, Weining; Wang, Fuyu

2017-09-01

Reasonable operation can increase the income of the hospital and improve the patient’s satisfactory level. In this paper, by using multi object operation scheduling method with improved NSGA algorithm, it shortens the operation time, reduces the operation costand lowers the operation risk, the multi-objective optimization model is established for flexible operation scheduling, through the MATLAB simulation method, the Pareto solution is obtained, the standardization of data processing. The optimal scheduling scheme is selected by using entropy weight -Topsis combination method. The results show that the algorithm is feasible to solve the multi-objective operation scheduling problem, and provide a reference for hospital operation scheduling.

The Worst-Case Weighted Multi-Objective Game with an Application to Supply Chain Competitions.

PubMed

Qu, Shaojian; Ji, Ying

2016-01-01

In this paper, we propose a worst-case weighted approach to the multi-objective n-person non-zero sum game model where each player has more than one competing objective. Our "worst-case weighted multi-objective game" model supposes that each player has a set of weights to its objectives and wishes to minimize its maximum weighted sum objectives where the maximization is with respect to the set of weights. This new model gives rise to a new Pareto Nash equilibrium concept, which we call "robust-weighted Nash equilibrium". We prove that the robust-weighted Nash equilibria are guaranteed to exist even when the weight sets are unbounded. For the worst-case weighted multi-objective game with the weight sets of players all given as polytope, we show that a robust-weighted Nash equilibrium can be obtained by solving a mathematical program with equilibrium constraints (MPEC). For an application, we illustrate the usefulness of the worst-case weighted multi-objective game to a supply chain risk management problem under demand uncertainty. By the comparison with the existed weighted approach, we show that our method is more robust and can be more efficiently used for the real-world applications.

Cosmological surveys with multi-object spectrographs

NASA Astrophysics Data System (ADS)

Colless, Matthew

2016-08-01

Multi-object spectroscopy has been a key technique contributing to the current era of `precision cosmology.' From the first exploratory surveys of the large-scale structure and evolution of the universe to the current generation of superbly detailed maps spanning a wide range of redshifts, multi-object spectroscopy has been a fundamentally important tool for mapping the rich structure of the cosmic web and extracting cosmological information of increasing variety and precision. This will continue to be true for the foreseeable future, as we seek to map the evolving geometry and structure of the universe over the full extent of cosmic history in order to obtain the most precise and comprehensive measurements of cosmological parameters. Here I briefly summarize the contributions that multi-object spectroscopy has made to cosmology so far, then review the major surveys and instruments currently in play and their prospects for pushing back the cosmological frontier. Finally, I examine some of the next generation of instruments and surveys to explore how the field will develop in coming years, with a particular focus on specialised multi-object spectrographs for cosmology and the capabilities of multi-object spectrographs on the new generation of extremely large telescopes.

Improving multi-objective reservoir operation optimization with sensitivity-informed dimension reduction

NASA Astrophysics Data System (ADS)

Chu, J.; Zhang, C.; Fu, G.; Li, Y.; Zhou, H.

2015-08-01

This study investigates the effectiveness of a sensitivity-informed method for multi-objective operation of reservoir systems, which uses global sensitivity analysis as a screening tool to reduce computational demands. Sobol's method is used to screen insensitive decision variables and guide the formulation of the optimization problems with a significantly reduced number of decision variables. This sensitivity-informed method dramatically reduces the computational demands required for attaining high-quality approximations of optimal trade-off relationships between conflicting design objectives. The search results obtained from the reduced complexity multi-objective reservoir operation problems are then used to pre-condition the full search of the original optimization problem. In two case studies, the Dahuofang reservoir and the inter-basin multi-reservoir system in Liaoning province, China, sensitivity analysis results show that reservoir performance is strongly controlled by a small proportion of decision variables. Sensitivity-informed dimension reduction and pre-conditioning are evaluated in their ability to improve the efficiency and effectiveness of multi-objective evolutionary optimization. Overall, this study illustrates the efficiency and effectiveness of the sensitivity-informed method and the use of global sensitivity analysis to inform dimension reduction of optimization problems when solving complex multi-objective reservoir operation problems.

Improving multi-objective reservoir operation optimization with sensitivity-informed problem decomposition

NASA Astrophysics Data System (ADS)

Chu, J. G.; Zhang, C.; Fu, G. T.; Li, Y.; Zhou, H. C.

2015-04-01

This study investigates the effectiveness of a sensitivity-informed method for multi-objective operation of reservoir systems, which uses global sensitivity analysis as a screening tool to reduce the computational demands. Sobol's method is used to screen insensitive decision variables and guide the formulation of the optimization problems with a significantly reduced number of decision variables. This sensitivity-informed problem decomposition dramatically reduces the computational demands required for attaining high quality approximations of optimal tradeoff relationships between conflicting design objectives. The search results obtained from the reduced complexity multi-objective reservoir operation problems are then used to pre-condition the full search of the original optimization problem. In two case studies, the Dahuofang reservoir and the inter-basin multi-reservoir system in Liaoning province, China, sensitivity analysis results show that reservoir performance is strongly controlled by a small proportion of decision variables. Sensitivity-informed problem decomposition and pre-conditioning are evaluated in their ability to improve the efficiency and effectiveness of multi-objective evolutionary optimization. Overall, this study illustrates the efficiency and effectiveness of the sensitivity-informed method and the use of global sensitivity analysis to inform problem decomposition when solving the complex multi-objective reservoir operation problems.

Multi objective multi refinery optimization with environmental and catastrophic failure effects objectives

NASA Astrophysics Data System (ADS)

Khogeer, Ahmed Sirag

2005-11-01

Petroleum refining is a capital-intensive business. With stringent environmental regulations on the processing industry and declining refining margins, political instability, increased risk of war and terrorist attacks in which refineries and fuel transportation grids may be targeted, higher pressures are exerted on refiners to optimize performance and find the best combination of feed and processes to produce salable products that meet stricter product specifications, while at the same time meeting refinery supply commitments and of course making profit. This is done through multi objective optimization. For corporate refining companies and at the national level, Intea-Refinery and Inter-Refinery optimization is the second step in optimizing the operation of the whole refining chain as a single system. Most refinery-wide optimization methods do not cover multiple objectives such as minimizing environmental impact, avoiding catastrophic failures, or enhancing product spec upgrade effects. This work starts by carrying out a refinery-wide, single objective optimization, and then moves to multi objective-single refinery optimization. The last step is multi objective-multi refinery optimization, the objectives of which are analysis of the effects of economic, environmental, product spec, strategic, and catastrophic failure. Simulation runs were carried out using both MATLAB and ASPEN PIMS utilizing nonlinear techniques to solve the optimization problem. The results addressed the need to debottleneck some refineries or transportation media in order to meet the demand for essential products under partial or total failure scenarios. They also addressed how importing some high spec products can help recover some of the losses and what is needed in order to accomplish this. In addition, the results showed nonlinear relations among local and global objectives for some refineries. The results demonstrate that refineries can have a local multi objective optimum that does not follow the same trends as either global or local single objective optimums. Catastrophic failure effects on refinery operations and on local objectives are more significant than environmental objective effects, and changes in the capacity or the local objectives follow a discrete behavioral pattern, in contrast to environmental objective cases in which the effects are smoother. (Abstract shortened by UMI.)

Indicators of carbon storage in U.S. ecosystems: baseline for terrestrial carbon accounting.

PubMed

Negra, Christine; Sweedo, Caroline Cremer; Cavender-Bares, Kent; O'Malley, Robin

2008-01-01

Policymakers, program managers, and landowners need information about net terrestrial carbon sequestration in forests, croplands, grasslands, and shrublands to understand the cumulative effects of carbon trading programs, expanding biofuels production, and changing environmental conditions in addition to agricultural and forestry uses. Objective information systems that establish credible baselines and track changes in carbon storage can provide the accountability needed for carbon trading programs to achieve durable carbon sequestration and for biofuels initiatives to reduce net greenhouse gas emissions. A multi-sector stakeholder design process was used to produce a new indicator for the 2008 State of the Nation's Ecosystems report that presents metrics of carbon storage for major ecosystem types, specifically change in the amount of carbon gained or lost over time and the amount of carbon stored per unit area (carbon density). These metrics have been developed for national scale use, but are suitable for adaptation to multiple scales such as individual farm and forest parcels, carbon offset markets and integrated national and international assessments. To acquire the data necessary for a complete understanding of how much, and where, carbon is gained or lost by U.S. ecosystems, expansion and integration of monitoring programs will be required.

Training teachers in generalized writing of behavior modification programs for multihandicapped deaf children.

PubMed

Hundert, J

1982-01-01

In contrast to previous studies where teachers were instructed how to implement behavior modification programs designed by an experimenter, teachers in the present experiment were taught how to write as well as implement behavior modification programs. The generalized effects of two training conditions on teacher and pupil behaviors were assessed by a multiple baseline design where, following baseline, two teachers of multi-handicapped deaf children were taught to set objectives and measure pupil performance (measurement training), Later, through a training manual, they learned a general problem-solving approach to writing behavior modification programs (programming training). After both training conditions, experimenter feedback was given for teachers' application of training to a target behavior for one pupil and generalization was measured across target behaviors for the same pupil and across pupils. It was found that measurement training had little general effect on either teacher behavior or pupil behavior. However, after programming training, teachers increased their program writing and correct use of behavior modification procedures and generalized this training across pupils and target behaviors. Along with these effects, there was improvement in pupil behaviors. Possible explanation for generalized effects of teacher training were considered.

Negative Attachment Cognitions and Emotional Distress in mainland Chinese Adolescents: A Prospective Multi-Wave Test of Vulnerability-Stress and Stress Generation Models

PubMed Central

Cohen, Joseph R.; Hankin, Benjamin L.; Gibb, Brandon E.; Hammen, Constance; Hazel, Nicholas A.; Ma, Denise; Yao, Shuqiao; Zhu, Xiong Zhao; Abela, John R.Z.

2014-01-01

Objective The present study examined the relation between attachment cognitions, stressors, and emotional distress in a sample of Chinese adolescents. Specifically, it was examined whether negative attachment cognitions predicted depression and anxiety symptoms, and if a vulnerability-stress or stress generation model best explained the relation between negative attachment cognitions and internalizing symptoms. Method Participants included 558 adolescents (310 females and 248 males) from an urban school in Changsha, and 592 adolescents (287 females and 305 males) from a rural school in Liuyang, both in Hunan province located in mainland China. Participants completed self-report measures of negative attachment cognitions at baseline, and self-report measures of negative events, depression symptoms, and anxiety symptoms at baseline and at regular one month intervals for an overall 6-month follow-up (i.e., six follow-up assessments). Results Higher levels of negative attachment cognitions predicted prospective depression and anxiety symptoms. Furthermore, support was found for a stress generation model that partially mediated this longitudinal association. No support was found for a vulnerability-stress model. Conclusion Overall, these findings highlight new developmental pathways for development of depression and anxiety symptoms in mainland Chinese adolescents. PMID:23237030

Effectiveness of a Multi-Component Intervention for Overweight and Obese Children (Nereu Program): A Randomized Controlled Trial

PubMed Central

Serra-Paya, Noemi; Ensenyat, Assumpta; Castro-Viñuales, Iván; Real, Jordi; Sinfreu-Bergués, Xènia; Zapata, Amalia; Mur, Jose María; Galindo-Ortego, Gisela; Solé-Mir, Eduard; Teixido, Concepció

2015-01-01

Introduction Treatment of childhood obesity is a complex challenge for primary health care professionals. Objectives To evaluate the effectiveness of the Nereu Program in improving anthropometric parameters, physical activity and sedentary behaviours, and dietary intake. Methods Randomized, controlled, multicentre clinical trial comparing Nereu Program and usual counselling group interventions in primary care settings. The 8-month study recruited 113 children aged 6 to 12 years with overweight/obesity. Before recruitment, eligible participants were randomly allocated to an intensive, family-based multi-component behavioural intervention (Nereu Program group) or usual advice from their paediatrician on healthy eating and physical activity. Anthropometric parameters, objectively measured sedentary and physical activity behaviours, and dietary intake were evaluated pre- and post-intervention. Results At the end of the study period, both groups achieved a similar decrease in body mass index (BMIsd) compared to baseline. Nereu Program participants (n = 54) showed greater increases in moderate-intense physical activity (+6.27% vs. -0.61%, p<0.001) and daily fruit servings (+0.62 vs. +0.13, p<0.026), and decreased daily soft drinks consumption (-0.26 vs. -0.02, p<0.047), respectively, compared to the counselling group (n = 59). Conclusions At the end of the 8-month intervention, participants in the Nereu Program group showed improvement in physical activity and dietary behaviours, compared to the counselling group. Trial Registration ClinicalTrials.gov NCT01878994 PMID:26658988

Combinatorial Optimization in Project Selection Using Genetic Algorithm

NASA Astrophysics Data System (ADS)

Dewi, Sari; Sawaluddin

2018-01-01

This paper discusses the problem of project selection in the presence of two objective functions that maximize profit and minimize cost and the existence of some limitations is limited resources availability and time available so that there is need allocation of resources in each project. These resources are human resources, machine resources, raw material resources. This is treated as a consideration to not exceed the budget that has been determined. So that can be formulated mathematics for objective function (multi-objective) with boundaries that fulfilled. To assist the project selection process, a multi-objective combinatorial optimization approach is used to obtain an optimal solution for the selection of the right project. It then described a multi-objective method of genetic algorithm as one method of multi-objective combinatorial optimization approach to simplify the project selection process in a large scope.

Multi-object detection and tracking technology based on hexagonal opto-electronic detector

NASA Astrophysics Data System (ADS)

Song, Yong; Hao, Qun; Li, Xiang

2008-02-01

A novel multi-object detection and tracking technology based on hexagonal opto-electronic detector is proposed, in which (1) a new hexagonal detector, which is composed of 6 linear CCDs, has been firstly developed to achieve the field of view of 360 degree, (2) to achieve the detection and tracking of multi-object with high speed, the object recognition criterions of Object Signal Width Criterion (OSWC) and Horizontal Scale Ratio Criterion (HSRC) are proposed. In this paper, Simulated Experiments have been carried out to verify the validity of the proposed technology, which show that the detection and tracking of multi-object can be achieved with high speed by using the proposed hexagonal detector and the criterions of OSWC and HSRC, indicating that the technology offers significant advantages in Photo-electric Detection, Computer Vision, Virtual Reality, Augment Reality, etc.

Using Multi-Component Consultation to Increase the Integrity with Which Teachers Implement Behavioral Classroom Interventions: A Pilot Study

ERIC Educational Resources Information Center

Owens, Julie Sarno; Coles, Erika K.; Evans, Steven W.; Himawan, Lina K.; Girio-Herrera, Erin; Holdaway, Alex S.; Zoromski, Allison K.; Schamberg, Terah; Schulte, Ann

2017-01-01

The goal of this pilot study was to evaluate the effectiveness of a multi-component consultation package in improving teachers' classroom management skills, particularly among teachers with lower baseline levels of knowledge, skills, and intervention-supportive beliefs. Participants were 58 elementary school teachers (93% female; 50% Non-Hispanic…

Multi-trigger resist patterning with ASML NXE3300 EUV scanner

NASA Astrophysics Data System (ADS)

Vesters, Yannick; McClelland, Alexandra; De Simone, Danilo; Popescu, Carmen; Dawson, Guy; Roth, John; Theis, Wolfgang; Vandenberghe, Geert; Robinson, Alex P. G.

2018-03-01

Irresistible Materials (IM) is developing novel resist systems based on the multi-trigger concept, which incorporates a dose dependent quenching-like behaviour. The Multi Trigger Resist (MTR) is a negative tone crosslinking resist that does not need a post exposure bake (PEB), and during the past years, has been mainly tested using interference lithography at PSI. In this study, we present the results that have been obtained using MTR resists, performing EUV exposures on ASML NXE3300B EUV scanner at IMEC. We present the lithography performance of the MTR1 resist series in two formulations - a high-speed baseline, and a formulation designed to enhance the multi-trigger behaviour. Additionally, we present results for the MTR2 resist series, which has been designed for lower line edge roughness. The high-speed baseline resist (MTR1), showed 18 nm resolution at 20mJ/cm2. The MTR2 resist shows 16nm half pitch lines patterned with a dose of 38mJ/cm2, giving a LER of 3.7 nm. Performance across multiple process conditions are discussed. We performed etch rate measurement and the multi-trigger resist showed etch resistance equivalent or better than standard chemically amplified resist. This could compensate for the lower film thickness required to avoid pattern collapse at pitch 32nm.

Confidence-Based Data Association and Discriminative Deep Appearance Learning for Robust Online Multi-Object Tracking.

PubMed

Bae, Seung-Hwan; Yoon, Kuk-Jin

2018-03-01

Online multi-object tracking aims at estimating the tracks of multiple objects instantly with each incoming frame and the information provided up to the moment. It still remains a difficult problem in complex scenes, because of the large ambiguity in associating multiple objects in consecutive frames and the low discriminability between objects appearances. In this paper, we propose a robust online multi-object tracking method that can handle these difficulties effectively. We first define the tracklet confidence using the detectability and continuity of a tracklet, and decompose a multi-object tracking problem into small subproblems based on the tracklet confidence. We then solve the online multi-object tracking problem by associating tracklets and detections in different ways according to their confidence values. Based on this strategy, tracklets sequentially grow with online-provided detections, and fragmented tracklets are linked up with others without any iterative and expensive association steps. For more reliable association between tracklets and detections, we also propose a deep appearance learning method to learn a discriminative appearance model from large training datasets, since the conventional appearance learning methods do not provide rich representation that can distinguish multiple objects with large appearance variations. In addition, we combine online transfer learning for improving appearance discriminability by adapting the pre-trained deep model during online tracking. Experiments with challenging public datasets show distinct performance improvement over other state-of-the-arts batch and online tracking methods, and prove the effect and usefulness of the proposed methods for online multi-object tracking.

Multi-objective possibilistic model for portfolio selection with transaction cost

NASA Astrophysics Data System (ADS)

Jana, P.; Roy, T. K.; Mazumder, S. K.

2009-06-01

In this paper, we introduce the possibilistic mean value and variance of continuous distribution, rather than probability distributions. We propose a multi-objective Portfolio based model and added another entropy objective function to generate a well diversified asset portfolio within optimal asset allocation. For quantifying any potential return and risk, portfolio liquidity is taken into account and a multi-objective non-linear programming model for portfolio rebalancing with transaction cost is proposed. The models are illustrated with numerical examples.

Next Generation Space Telescope Integrated Science Module Data System

NASA Technical Reports Server (NTRS)

Schnurr, Richard G.; Greenhouse, Matthew A.; Jurotich, Matthew M.; Whitley, Raymond; Kalinowski, Keith J.; Love, Bruce W.; Travis, Jeffrey W.; Long, Knox S.

1999-01-01

The Data system for the Next Generation Space Telescope (NGST) Integrated Science Module (ISIM) is the primary data interface between the spacecraft, telescope, and science instrument systems. This poster includes block diagrams of the ISIM data system and its components derived during the pre-phase A Yardstick feasibility study. The poster details the hardware and software components used to acquire and process science data for the Yardstick instrument compliment, and depicts the baseline external interfaces to science instruments and other systems. This baseline data system is a fully redundant, high performance computing system. Each redundant computer contains three 150 MHz power PC processors. All processors execute a commercially available real time multi-tasking operating system supporting, preemptive multi-tasking, file management and network interfaces. These six processors in the system are networked together. The spacecraft interface baseline is an extension of the network, which links the six processors. The final selection for Processor busses, processor chips, network interfaces, and high-speed data interfaces will be made during mid 2002.

Learned filters for object detection in multi-object visual tracking

NASA Astrophysics Data System (ADS)

Stamatescu, Victor; Wong, Sebastien; McDonnell, Mark D.; Kearney, David

2016-05-01

We investigate the application of learned convolutional filters in multi-object visual tracking. The filters were learned in both a supervised and unsupervised manner from image data using artificial neural networks. This work follows recent results in the field of machine learning that demonstrate the use learned filters for enhanced object detection and classification. Here we employ a track-before-detect approach to multi-object tracking, where tracking guides the detection process. The object detection provides a probabilistic input image calculated by selecting from features obtained using banks of generative or discriminative learned filters. We present a systematic evaluation of these convolutional filters using a real-world data set that examines their performance as generic object detectors.

Leveraging Human Insights by Combining Multi-Objective Optimization with Interactive Evolution

DTIC Science & Technology

2015-03-26

application, a program that used human selections to guide the evolution of insect -like images. He was able to demonstrate that humans provide key insights...LEVERAGING HUMAN INSIGHTS BY COMBINING MULTI-OBJECTIVE OPTIMIZATION WITH INTERACTIVE EVOLUTION THESIS Joshua R. Christman, Second Lieutenant, USAF...COMBINING MULTI-OBJECTIVE OPTIMIZATION WITH INTERACTIVE EVOLUTION THESIS Presented to the Faculty Department of Electrical and Computer Engineering

VLBA Teams With Optical Interferometer to Study Star's Layers

NASA Astrophysics Data System (ADS)

2007-05-01

Two of the World's Largest Interferometric Facilities Team-up to Study a Red Giant Star Using ESO's VLTI on Cerro Paranal and the VLBA facility operated by NRAO, an international team of astronomers has made what is arguably the most detailed study of the environment of a pulsating red giant star. They performed, for the first time, a series of coordinated observations of three separate layers within the star's tenuous outer envelope: the molecular shell, the dust shell, and the maser shell, leading to significant progress in our understanding of the mechanism of how, before dying, evolved stars lose mass and return it to the interstellar medium. S Orionis (S Ori) belongs to the class of Mira-type variable stars. It is a solar-mass star that, as will be the fate of our Sun in 5 billion years, is nearing its gloomy end as a white dwarf. Mira stars are very large and lose huge amounts of matter. Every year, S Ori ejects as much as the equivalent of Earth's mass into the cosmos. ESO PR Photo 25a/07 ESO PR Photo 25a/07 Evolution of the Mira-type Star S Orionis "Because we are all stardust, studying the phases in the life of a star when processed matter is sent back to the interstellar medium to be used for the next generation of stars, planets... and humans, is very important," said Markus Wittkowski, lead author of the paper reporting the results. A star such as the Sun will lose between a third and half of its mass during the Mira phase. S Ori pulsates with a period of 420 days. In the course of its cycle, it changes its brightness by a factor of the order of 500, while its diameter varies by about 20%. Although such stars are enormous - they are typically larger than the current Sun by a factor of a few hundred, i.e. they encompass the orbit of the Earth around the Sun - they are also distant and to peer into their deep envelopes requires very high resolution. This can only be achieved with interferometric techniques. ESO PR Photo 25b/07 ESO PR Photo 25b/07 Structure of S Ori (Artist's Impression) "Astronomers are like medical doctors, who use various instruments to examine different parts of the human body," said co-author David Boboltz. "While the mouth can be checked with a simple light, a stethoscope is required to listen to the heart beat. Similarly the heart of the star can be observed in the optical, the molecular and dust layers can be studied in the infrared and the maser emission can be probed with radio instruments. Only the combination of the three gives us a more complete picture of the star and its envelope." The maser emission comes from silicon monoxide (SiO) molecules and can be used to image and track the motion of gas clouds in the stellar envelope roughly 10 times the size of the Sun. The astronomers observed S Ori with two of the largest interferometric facilities available: the ESO Very Large Telescope Interferometer (VLTI) at Paranal, observing in the near- and mid-infrared, and the NRAO-operated Very Long Baseline Array (VLBA), that takes measurements in the radio wave domain. Because the star's luminosity changes periodically, the astronomers observed it simultaneously with both instruments, at several different epochs. The first epoch occurred close to the stellar minimum luminosity and the last just after the maximum on the next cycle. ESO PR Photo 25c/07 ESO PR Photo 25c/07 S Ori to Scale (Artist's Impression) The astronomers found the star's diameter to vary between 7.9 milliarcseconds and 9.7 milliarcseconds. At the distance of S Ori, this corresponds to a change of the radius from about 1.9 to 2.3 times the distance between the Earth and the Sun, or between 400 and 500 solar radii! As if such sizes were not enough, the inner dust shell is found to be about twice as big. The maser spots, which also form at about twice the radius of the star, show the typical structure of partial to full rings with a clumpy distribution. Their velocities indicate that the gas is expanding radially, moving away at a speed of about 10 km/s. The multi-wavelength analysis indicates that near the minimum there is more dust production and mass ejection: in these phases indeed the amount of dust is significantly higher than in the others. After this intense matter production and ejection the star continues its pulsation and when it reaches the maximum luminosity, it displays a much more expanded dust shell. This clearly supports a strong connection between the Mira pulsation and the dust production and expulsion. Furthermore, the astronomers found that grains of aluminum oxide - also called corundum - constitute most of S Ori's dust shell: the grain size is estimated to be of the order of 10 millionths of a centimetre, that is one thousand times smaller than the diameter of a human hair. "We know one chapter of the secret life of a Mira star, but much more can be learned in the near future, when we add near-infrared interferometry with the AMBER instrument on the VLTI to our (already broad) observational approach," said Wittkowski. More Information The research presented here is reported in a paper in press in the journal Astronomy and Astrophysics ("The Mira variable S Ori: Relationships between the photosphere, molecular layer, dust shell, and SiO maser shell at 4 epochs", by M. Wittkowski et al.). It is available in PDF format from the publisher's web site. The team consists of Markus Wittkowski (ESO), David A. Boboltz (U.S. Naval Observatory, USA), Keiichi Ohnaka and Thomas Driebe (MPIfR Bonn, Germany), and Michael Scholz (University of Heidelberg, Germany and University of Sydney, Australia). Notes A maser is the microwave equivalent to a laser, which emits visible light. A maser emits powerful microwave radiation instead and its study requires radio telescopes. An astrophysical maser is a naturally occurring source of stimulated emission that may arise in molecular clouds, comets, planetary atmospheres, stellar atmospheres, or from various conditions in interstellar space. ESO operates the Very Large Telescope Interferometer at Paranal Observatory, Chile, with four fixed 8.2-m telescopes and four relocatable 1.8-m telescopes, working at optical/infrared wavelengths. NRAO operates the Very Long Baseline Array with 10 stations across the U.S. working at radio wavelengths between 3 mm and 90 cm (0.3-90 GHz). ESO, NRAO and other partners will operate the Atacama Large Millimeter/submillimeter Array (ALMA) in Chile, working at millimetre wavelengths between 0.3 and 10 mm (30-950 GHz)

Secure content objects

DOEpatents

Evans, William D [Cupertino, CA

2009-02-24

A secure content object protects electronic documents from unauthorized use. The secure content object includes an encrypted electronic document, a multi-key encryption table having at least one multi-key component, an encrypted header and a user interface device. The encrypted document is encrypted using a document encryption key associated with a multi-key encryption method. The encrypted header includes an encryption marker formed by a random number followed by a derivable variation of the same random number. The user interface device enables a user to input a user authorization. The user authorization is combined with each of the multi-key components in the multi-key encryption key table and used to try to decrypt the encrypted header. If the encryption marker is successfully decrypted, the electronic document may be decrypted. Multiple electronic documents or a document and annotations may be protected by the secure content object.

Potential Effects of a Scenario Earthquake on the Economy of Southern California: Baseline County-Level Migration Characteristics and Trends 1995-2000 and 2001-2010

USGS Publications Warehouse

Sherrouse, Benson C.; Hester, David J.

2008-01-01

The Multi-Hazards Demonstration Project (MHDP) is a collaboration between the U.S. Geological Survey (USGS) and various partners from the public and private sectors and academia, meant to improve Southern California's resiliency to natural hazards. In support of the MHDP objectives, the ShakeOut Scenario was developed. It describes a magnitude 7.8 earthquake along the southernmost 300 kilometers (200 miles) of the San Andreas Fault, identified by geoscientists as a plausible event that will cause moderate to strong shaking over much of the eight-county (Imperial, Kern, Los Angeles, Orange, Riverside, San Bernardino, San Diego, and Ventura) Southern California region. This report uses historical, estimated, and projected population data from several Federal and State data sources to estimate baseline characteristics and trends of the region's population migration (that is, changes in a person's place of residence over time). The analysis characterizes migration by various demographic, economic, family, and household variables for the period 1995-2000. It also uses existing estimates (beginning in 2001) of the three components of population change - births, deaths, and migration - to extrapolate near-term projections of county-level migration trends through 2010. The 2010 date was chosen to provide baseline projections corresponding to a two-year recovery period following the November 2008 date that was selected for the occurrence of the ShakeOut Scenario earthquake. The baseline characteristics and projections shall assist with evaluating the effects of inflow and outflow migration trends for alternative futures in which the simulated M7.8 earthquake either does or does not occur and the impact of the event on housing and jobs, as well as community composition and regional economy changes based on dispersion of intellectual, physical, economic, and cultural capital.

Gender differences among treatment-seeking adults with cannabis use disorder: Clinical profiles of women and men enrolled in the Achieving Cannabis Cessation – Evaluating N-acetylcysteine Treatment (ACCENT) study

PubMed Central

Sherman, Brian J.; McRae-Clark, Aimee L.; Baker, Nathaniel L.; Sonne, Susan C.; Killeen, Therese K.; Cloud, Kasie; Gray, Kevin M.

2017-01-01

Background and Objectives Recent evidence suggests that women may fare worse than men in cannabis trials with pharmacologic interventions. Identifying baseline clinical profiles of treatment-seeking cannabis-dependent adults could inform gender-specific treatment planning and development. Methods The current study compared baseline demographic, cannabis use, and psychiatric factors between women (n = 86) and men (n = 216) entering the Achieving Cannabis Cessation – Evaluating N-acetylcysteine Treatment (ACCENT) study, a multi-site, randomized controlled trial conducted within the National Drug Abuse Treatment Clinical Trials Network. Results Women reported greater withdrawal intensity (p = 0.001) and negative impact of withdrawal (p = 0.001), predominantly due to physiological and mood symptoms. Women were more likely to have lifetime panic disorder (p = 0.038) and current agoraphobia (p = 0.022), and reported more days of poor physical health (p = 0.006) and cannabis-related medical problems (p = 0.023). Women reporting chronic pain had greater mean pain scores than men with chronic pain (p = 0.006). Men and women did not differ on any measures of baseline cannabis use. Discussion and Conclusion Cannabis-dependent women may present for treatment with more severe and impairing withdrawal symptoms and psychiatric conditions compared to cannabis-dependent men. This might help explain recent evidence suggesting that women fare worse than men in cannabis treatment trials of pharmacologic interventions. Baseline clinical profiles of treatment-seeking adults can inform gender-specific treatment planning and development. Scientific Significance Cannabis-dependent women may benefit from integrated treatment focusing on co-occurring psychiatric disorders and targeted treatment of cannabis withdrawal syndrome. PMID:28152236

Health-related quality of life in adults with relapsed/refractory acute lymphoblastic leukemia treated with blinatumomab.

PubMed

Topp, Max S; Zimmerman, Zachary; Cannell, Paul; Dombret, Hervé; Maertens, Johan; Stein, Anthony; Franklin, Janet; Tran, Qui; Cong, Ze; Schuh, Andre C

2018-05-08

In the phase 3 TOWER study, blinatumomab significantly improved overall survival in adults with relapsed or refractory (R/R) Philadelphia chromosome-negative (Ph-) B-cell precursor acute lymphoblastic leukemia (BCP-ALL) relative to standard-of-care chemotherapy. A secondary objective of this study was to assess the impact of blinatumomab on health-related quality of life (HRQL) as measured by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30). This analysis included the 342 of 405 randomized patients for whom baseline and ≥1 post-baseline result were available in any EORTC multi-item scale or single-item measure. In general, patients receiving blinatumomab (n=247) reported better posttreatment HRQL across all QLQ-C30 subscales, based on descriptive mean change from baseline, than did those receiving chemotherapy (n=95). The hazard ratios for time to a ≥10-point deterioration from baseline (TTD) in HRQL or death ranged from 0.42 to 0.81 in favor of blinatumomab, with the upper bounds of the 95% CI <1.0 across all measures, except insomnia, social functioning, and financial difficulties; sensitivity analysis of TTD in HRQL without the event of death were consistent with these findings. When treatment effect over time was tested using a restricted maximum likelihood-based mixed model for repeated measures analysis, p<0.05 was reached for blinatumomab vs chemotherapy for all subscale measures except financial difficulties. The clinically meaningful benefits in overall survival and HRQL support the clinical value of blinatumomab in patients with R/R Ph- BCP-ALL when compared with chemotherapy. Funded by Amgen (TOWER ClinicalTrials.gov number, NCT02013167). Copyright © 2018 American Society of Hematology.

Phenotypic factors influencing the variation in response of circulating cholesterol level to personalised dietary advice in the Food4Me study.

PubMed

Kirwan, Laura; Walsh, Marianne C; Celis-Morales, Carlos; Marsaux, Cyril F M; Livingstone, Katherine M; Navas-Carretero, Santiago; Fallaize, Rosalind; O'Donovan, Clare B; Woolhead, Clara; Forster, Hannah; Kolossa, Silvia; Daniel, Hannelore; Moschonis, George; Manios, Yannis; Surwillo, Agnieszka; Godlewska, Magdalena; Traczyk, Iwona; Drevon, Christian A; Gibney, Mike J; Lovegrove, Julie A; Martinez, J Alfredo; Saris, Wim H M; Mathers, John C; Gibney, Eileen R; Brennan, Lorraine

2016-12-01

Individual response to dietary interventions can be highly variable. The phenotypic characteristics of those who will respond positively to personalised dietary advice are largely unknown. The objective of this study was to compare the phenotypic profiles of differential responders to personalised dietary intervention, with a focus on total circulating cholesterol. Subjects from the Food4Me multi-centre study were classified as responders or non-responders to dietary advice on the basis of the change in cholesterol level from baseline to month 6, with lower and upper quartiles defined as responder and non-responder groups, respectively. There were no significant differences between demographic and anthropometric profiles of the groups. Furthermore, with the exception of alcohol, there was no significant difference in reported dietary intake, at baseline. However, there were marked differences in baseline fatty acid profiles. The responder group had significantly higher levels of stearic acid (18 : 0, P=0·034) and lower levels of palmitic acid (16 : 0, P=0·009). Total MUFA (P=0·016) and total PUFA (P=0·008) also differed between the groups. In a step-wise logistic regression model, age, baseline total cholesterol, glucose, five fatty acids and alcohol intakes were selected as factors that successfully discriminated responders from non-responders, with sensitivity of 82 % and specificity of 83 %. The successful delivery of personalised dietary advice may depend on our ability to identify phenotypes that are responsive. The results demonstrate the potential use of metabolic profiles in identifying response to an intervention and could play an important role in the development of precision nutrition.

Tribute to Jean-Marie Mariotti

NASA Astrophysics Data System (ADS)

Lena, Pierre J.

2003-02-01

Jean-Marie Mariotti (1955 - 1998) prematurely passed away after too short a career of optician and astronomer. With his students, his contributions to the nascent field of high angular resolution at optical wavelengths, and especially to interferometry, both on the ground and in space, have been remarkable. Pioneering the use of single-mode optical fibers and integrated optics, he pushed the accuracy of visibility (amplitude) measurements to a fraction of a percent. His vision of a Mauna Kea kilometric interferometer using the existing giant telescopes is now becoming a reality with the 'OHANA project. His role in the emergence of the Very Large Telescope Interferometer (VLTI) and in the birth of the space mission DARWIN for exoplanets studies has been essential.

Mid-infrared interferometric variability of DG Tau: implications for the inner-disk structure .

NASA Astrophysics Data System (ADS)

Ábrahám, P.; Varga, J.; Gabányi, K. É.; Chen, L.; Kóspál, Á.; Ratzka, Th.; van Boekel, R.; Mosoni, L.; Henning, Th.

DG Tau is a low-mass young star whose strongly accreting disk shows a variable 10 mu m silicate feature, that may even turn temporarily from emission to absorption. Aiming to find the physical reason of this variability, we analysed multiepoch VLTI/MIDI interferometric observations. We found that the inner disk within 3 au radius exhibits a 10 mu m absorption feature related to amorphous silicate grains, while the outer disk displays a variable crystalline feature in emission, similar in shape to the spectrum of comet Hale-Bopp. The variability may be related to a fluctuating amount of dusty material above the disk surface, possibly due to turbulence.

On the Improvement of Convergence Performance for Integrated Design of Wind Turbine Blade Using a Vector Dominating Multi-objective Evolution Algorithm

NASA Astrophysics Data System (ADS)

Wang, L.; Wang, T. G.; Wu, J. H.; Cheng, G. P.

2016-09-01

A novel multi-objective optimization algorithm incorporating evolution strategies and vector mechanisms, referred as VD-MOEA, is proposed and applied in aerodynamic- structural integrated design of wind turbine blade. In the algorithm, a set of uniformly distributed vectors is constructed to guide population in moving forward to the Pareto front rapidly and maintain population diversity with high efficiency. For example, two- and three- objective designs of 1.5MW wind turbine blade are subsequently carried out for the optimization objectives of maximum annual energy production, minimum blade mass, and minimum extreme root thrust. The results show that the Pareto optimal solutions can be obtained in one single simulation run and uniformly distributed in the objective space, maximally maintaining the population diversity. In comparison to conventional evolution algorithms, VD-MOEA displays dramatic improvement of algorithm performance in both convergence and diversity preservation for handling complex problems of multi-variables, multi-objectives and multi-constraints. This provides a reliable high-performance optimization approach for the aerodynamic-structural integrated design of wind turbine blade.

Instance annotation for multi-instance multi-label learning

Treesearch

F. Briggs; X.Z. Fern; R. Raich; Q. Lou

2013-01-01

Multi-instance multi-label learning (MIML) is a framework for supervised classification where the objects to be classified are bags of instances associated with multiple labels. For example, an image can be represented as a bag of segments and associated with a list of objects it contains. Prior work on MIML has focused on predicting label sets for previously unseen...

Diet Soda Intake and Risk of Incident Metabolic Syndrome and Type 2 Diabetes in the Multi-Ethnic Study of Atherosclerosis (MESA)*

PubMed Central

Nettleton, Jennifer A.; Lutsey, Pamela L.; Wang, Youfa; Lima, João A.; Michos, Erin D.; Jacobs, David R.

2009-01-01

OBJECTIVE We determined associations between diet soda consumption and risk of incident metabolic syndrome, its components, and type 2 diabetes in the Multi-Ethnic Study of Atherosclerosis. RESEARCH DESIGN AND METHODS Diet soda consumption was assessed by food frequency questionnaire at baseline (2000–2002). Incident type 2 diabetes was identified at three follow-up examinations (2002–2003, 2004–2005, and 2005–2007) as fasting glucose >126 mg/dl, self-reported type 2 diabetes, or use of diabetes medication. Metabolic syndrome (and components) was defined by National Cholesterol Education Program Adult Treatment Panel III criteria. Hazard ratios (HRs) with 95% CI for type 2 diabetes, metabolic syndrome, and metabolic syndrome components were estimated, adjusting for demographic, lifestyle, and dietary confounders. RESULTS At least daily consumption of diet soda was associated with a 36% greater relative risk of incident metabolic syndrome and a 67% greater relative risk of incident type 2 diabetes compared with nonconsumption (HR 1.36 [95% CI 1.11–1.66] for metabolic syndrome and 1.67 [1.27–2.20] for type 2 diabetes). Of metabolic syndrome components, only high waist circumference (men ≥102 cm and women ≥88 cm) and high fasting glucose (≥100 mg/dl) were prospectively associated with diet soda consumption. Associations between diet soda consumption and type 2 diabetes were independent of baseline measures of adiposity or changes in these measures, whereas associations between diet soda and metabolic syndrome were not independent of these factors. CONCLUSIONS Although these observational data cannot establish causality, consumption of diet soda at least daily was associated with significantly greater risks of select incident metabolic syndrome components and type 2 diabetes. PMID:19151203

Sociodemographic Correlates of Cognition in the Multi-Ethnic Study of Atherosclerosis (MESA)

PubMed Central

Fitzpatrick, Annette L.; Rapp, Stephen R.; Luchsinger, Jose; Hill-Briggs, Felicia; Alonso, Alvaro; Gottesman, Rebecca; Lee, Hochang; Carnethon, Mercedes; Liu, Kiang; Williams, Kayleen; Sharrett, A. Richey.; Frazier-Wood, Alexis; Lyketsos, Constantine; Seeman, Teresa

2015-01-01

Objectives To describe the methodology utilized to evaluate cognitive function in the Multi-Ethnic Study of Atherosclerosis (MESA) and to present preliminary results by age, gender and race/ethnicity. Design Cross-sectional measurements of a prospective observational cohort. Setting Residents of 6 US communities free of cardiovascular disease at baseline (2000-02). Participants 4,591 adults who completed the 5th MESA clinical examination in 2011-12, mean age 70.3 (SD 9.5) years, 53.1% women, and 40.7% Non-Hispanic White, 26.4% Non-Hispanic Black, 21.4% Hispanic, and 11.5% Chinese. Measurements The cognitive battery consisted of the Cognitive Abilities Screening Instrument (version 2) to evaluate global cognition, the Digit Symbol Code for processing speed and Digit Spans Forward and Backward to assess memory. Demographic, socioeconomic, and cultural covariates were also collected for descriptive statistics and multivariate modeling. Results Associations between socio-economic factors and cognition revealed that age, race/ethnicity, education, occupational status, household income, health insurance type, household size, place of birth, years and generation in U.S., and the presence of the APOE4 allele were significantly associated with performance on the cognitive tests although patterns varied by specific test, racial/ethnicity, and socio-cultural factors. Conclusions As many of the influencing cultural and socioeconomic factors measured here are complex, multifactorial, and may not be adequately quantified, caution has been recommended with regard to comparison and interpretation of racial/ethnic group performance differences from these cross-sectional models. These data provide a baseline for future exams and more comprehensive longitudinal analyses of the contributions of subclinical and clinical diseases to cognitive function and decline. PMID:25704999

Lifetime risk of stroke in young-aged and middle-aged Chinese population: the Chinese Multi-Provincial Cohort Study

PubMed Central

Wang, Ying; Liu, Jing; Wang, Wei; Wang, Miao; Qi, Yue; Xie, Wuxiang; Li, Yan; Sun, Jiayi; Liu, Jun; Zhao, Dong

2016-01-01

Objective: Stroke is a major cause of premature death in China. Early prevention of stroke requires a more effective method to differentiate the stroke risk among young-aged and middle-aged individuals than the 10-year risk of cardiovascular disease. This study aimed to establish a lifetime stroke risk model and risk charts for the young-aged and middle-aged population in China. Methods: The Chinese Multi-Provincial Cohort Study participants (n = 21 953) aged 35–84 years without cardiovascular disease at baseline were followed for 18 years (263 016 person-years). Modified Kaplan–Meier method was used to estimate the mean lifetime stroke risk up to age of 80 years and the lifetime stroke risk according to major stroke risk factors for the population aged 35–60 years. Results: A total of 917 participants developed first-ever strokes. For the participants aged 35–40 years (98 stroke cases), the lifetime stroke risk was 18.0 and 14.7% in men and women, respectively. Blood pressure most effectively discriminated the lifetime stroke risk. The lifetime risk of stroke for the individuals with all risk factors optimal was 8–10 times lower compared with those with two or more high risk factors at age 35–60 years at baseline. Conclusion: In young-aged and middle-aged population, the lifetime stroke risk will keep very low if major risk factors especially blood pressure level is at optimal levels, but the risk substantially increases even with a slight elevation of major risk factors, which could not be identified using 10-year risk estimation. PMID:27512963

A prospective multi-centric open clinical trial of homeopathy in diabetic distal symmetric polyneuropathy.

PubMed

Nayak, Chaturbhuja; Oberai, Praveen; Varanasi, Roja; Baig, Hafeezullah; Ch, Raveender; Reddy, G R C; Devi, Pratima; S, Bhubaneshwari; Singh, Vikram; Singh, V P; Singh, Hari; Shitanshu, Shashi Shekhar

2013-04-01

To evaluate homeopathic treatment in the management of diabetic distal symmetric polyneuropathy. A prospective multi-centric clinical observational study was carried out from October 2005 to September 2009 by Central Council for Research in Homeopathy (CCRH) (India) at its five institutes/units. Patients suffering from diabetes mellitus (DM) and presenting with symptoms of diabetic polyneuropathy (DPN) were screened, investigated and were enrolled in the study after fulfilling the inclusion and exclusion criteria. Patients were evaluated by the diabetic distal symmetric polyneuropathy symptom score (DDSPSS) developed by the Council. A total of 15 homeopathic medicines were identified after repertorizing the nosological symptoms and signs of the disease. The appropriate constitutional medicine was selected and prescribed in 30, 200 and 1 M potency on an individualized basis. Patients were followed up regularly for 12 months. Out of 336 patients (167 males and 169 females) enrolled in the study, 247 patients (123 males and 124 females) were analyzed. All patients who attended at least three follow-up appointments and baseline curve conduction studies were included in the analysis.). A statistically significant improvement in DDSPSS total score (p = 0.0001) was found at 12 months from baseline. Most objective measures did not show significant improvement. Lycopodium clavatum (n = 132), Phosphorus (n = 27) and Sulphur (n = 26) were the medicines most frequently prescribed. Adverse event of hypoglycaemia was observed in one patient only. This study suggests homeopathic medicines may be effective in managing the symptoms of DPN patients. Further studies should be controlled and include the quality of life (QOL) assessment. Copyright © 2013 The Faculty of Homeopathy. Published by Elsevier Ltd. All rights reserved.

Mid-infrared interferometry of Seyfert galaxies: Challenging the Standard Model

NASA Astrophysics Data System (ADS)

López-Gonzaga, N.; Jaffe, W.

2016-06-01

Aims: We aim to find torus models that explain the observed high-resolution mid-infrared (MIR) measurements of active galactic nuclei (AGN). Our goal is to determine the general properties of the circumnuclear dusty environments. Methods: We used the MIR interferometric data of a sample of AGNs provided by the instrument MIDI/VLTI and followed a statistical approach to compare the observed distribution of the interferometric measurements with the distributions computed from clumpy torus models. We mainly tested whether the diversity of Seyfert galaxies can be described using the Standard Model idea, where differences are solely due to a line-of-sight (LOS) effect. In addition to the LOS effects, we performed different realizations of the same model to include possible variations that are caused by the stochastic nature of the dusty models. Results: We find that our entire sample of AGNs, which contains both Seyfert types, cannot be explained merely by an inclination effect and by including random variations of the clouds. Instead, we find that each subset of Seyfert type can be explained by different models, where the filling factor at the inner radius seems to be the largest difference. For the type 1 objects we find that about two thirds of our objects could also be described using a dusty torus similar to the type 2 objects. For the remaining third, it was not possible to find a good description using models with high filling factors, while we found good fits with models with low filling factors. Conclusions: Within our model assumptions, we did not find one single set of model parameters that could simultaneously explain the MIR data of all 21 AGN with LOS effects and random variations alone. We conclude that at least two distinct cloud configurations are required to model the differences in Seyfert galaxies, with volume-filling factors differing by a factor of about 5-10. A continuous transition between the two types cannot be excluded.

Study of physical conditions in protoplanetary disks by interferometry. Theory, instrumentation and first observations. -- étude des conditions physiques dans les disques protoplanétaires par interférométrie. Théorie, instrumentation et premières observations.

NASA Astrophysics Data System (ADS)

Malbet, Fabien

2007-10-01

Les étoiles se forment lors de l'effondrement de nuages de gaz et de poussière. Dans l'environnement proche de l'étoile naissante la matière se concentre dans un plan équatorial que l'on appelle disque protoplanétaire. Les astronomes pensent que les planètes se forment au sein de cette masse de gaz et de poussière orbitant autour de l'étoile. Pour sonder ces disques à des échelles correspondant aux orbites des futures planètes, il convient d'observer dans l'infrarouge à très haute résolution spatiale. L'interférométrie infrarouge est donc un outil idéal pour étudier les conditions physiques des disques protoplanétaires. Dans ce mémoire, je décris les premiers pas de l'interférométrie infrarouge, depuis la mise au point des petits interféromètres PTI et IOTA jusqu'à la construction de l'instrument AMBER au foyer de l'interféromètre du VLT. Je décris aussi les résultats d'une piste de recherche technologique particulièrement attrayante dans le cas de l'interférométrie infrarouge et issue des technologies des autoroutes de l'information: l'optique intégrée appliquée à la combinaison de plusieurs faisceaux en astronomie. Je montre ensuite comment à partir des observations obtenues à partir de ces instruments, il est possible de contraindre la physique des disques autour des étoiles jeunes. Gráce à la résolution spectrale nouvellement disponible sur ces instruments, pour la première fois nous pouvons séparer des phénomènes physiques aussi différents que l'accrétion de matière sur l'étoile et l'éjection de particules par des vents dont l'origine précise est encore mal connue. Les résultats présentés dans ce mémoire ont été obtenus principalement à partir d'observations sur les systèmes jeunes FU Ori et MWC 297 effectuées par AMBER sur le VLTI, mais aussi par les petits interféromètres infrarouges PTI et IOTA. Je développe aussi les travaux de modélisation de la structure verticale des disques associés afin de montrer la richesse des renseignements obtenus. Finalement je trace les contours d'un programme de recherche qui permettra tout d'abord de maximiser le retour astrophysique sur un instrument comme le VLTI, puis d'obtenir de premières images interférométriques de ces environnements circumstellaires. Je propose aussi la réalisation d'un instrument de seconde génération qui permettra de fournir des images interférométriques détaillées de ces sources compactes par synthèse d'ouverture. Stars are forming when clouds of gas and dust collapse. In the close environment of the new star, the matter is concentrated in an equatorial plane which is called protoplanetary disk. The astronomers think that planets are formed within this mass of gas and dust orbiting around the star. To probe these disks at scales corresponding to the orbits of the future planets, it is necessary to observe at very high spatial resolution in the infrared wavelength domain. Infrared interferometry is therefore an ideal tool to study the physical conditions in protoplanetary disks. In this document, I describe the first steps of infrared interferometry, from the beginning of the small interferometers PTI and IOTA until the construction of the AMBER instrument at the focus of the VLT Interferometer. I describe also the results of a technological research track, particularly attractive in the case of infrared interferometry, and coming from the information freeway: the integrated optics applies to the combination of several beams in astronomy. I show then how from observations obtained from these instruments, it is possible to constrain the physics of disks around young stars. Thanks to the spectral resolution recently available on these instruments, for the first time, we can separate the physical phenomena as different as accretion of matter onto the star and the ejection of particles by winds whose precise origin is still not well known. The results presented in this document were obtained mainly from observations on the young systems FU Ori and MWC 297 and performed by AMBER on the VLTI, but also by the small infrared interferometers PTI and IOTA. I tackle also the modeling of the vertical structure of those disks in order to show the wealth of obtained information. Finally I draw the contours of a research program that will allow first the VLTI astrophysical return to be maximized, and then the first interferometric images of these circumstellar environments to be obtained. I also propose to build a second generation instrument for the VLTI which will bring detailed interferometric images by aperture synthesis of these compact sources.

Research of flaw image collecting and processing technology based on multi-baseline stereo imaging

NASA Astrophysics Data System (ADS)

Yao, Yong; Zhao, Jiguang; Pang, Xiaoyan

2008-03-01

Aiming at the practical situations such as accurate optimal design, complex algorithms and precise technical demands of gun bore flaw image collecting, the design frame of a 3-D image collecting and processing system based on multi-baseline stereo imaging was presented in this paper. This system mainly including computer, electrical control box, stepping motor and CCD camera and it can realize function of image collection, stereo matching, 3-D information reconstruction and after-treatments etc. Proved by theoretical analysis and experiment results, images collected by this system were precise and it can slake efficiently the uncertainty problem produced by universally veins or repeated veins. In the same time, this system has faster measure speed and upper measure precision.

Preliminary design trade-offs for a multi-mission stored cryogen cooler

NASA Technical Reports Server (NTRS)

Sherman, A.

1978-01-01

Preliminary design studies were performed for a multi-mission solid cryogen cooler having a wide range of application for both the shuttle sortie and free flyer missions. This multi-mission cooler (MMC) is designed to be utilized with various solid cryogens to meet a wide range of instrument cooling from 10 K (with solid hydrogen) to 90 K. The baseline cooler utilizes two stages of solid cryogen and incorporates an optional, higher temperature third stage which is cooled by either a passive radiator or a thermoelectric cooler. The MMC has an interface which can accommodate a wide variety of instrument configurations. A shrink fit adapter is incorporated which allows a drop-in instrument integration. The baseline design provides cooling of approximately 1 watt over a 60 to 100 K temperature range and about 0.5 watts from 15 to 60 K for a one year lifetime. For low cooling loads and with use of the optional radiator shield, cooling lifetimes as great as 8 years are predicted.

Specific effects of a calorie-based intervention on stair climbing in overweight commuters.

PubMed

Lewis, Amanda L; Eves, Frank F

2011-10-01

Point-of-choice prompts consistently increase stair climbing; a greater increase in overweight than normal weight individuals was reported in a multi-component worksite campaign. The purpose of this study is to investigate effects of a multi-component campaign, on stair climbing, in a public access setting. In an interrupted-time-series-design, baseline observations (2 weeks) preceded a 2-week point-of-choice prompt. An additional message, positioned at the top of the climb for a further 6-week period, summarised the calorific consequences of a single ascent. Inconspicuous observers recorded traveller's methods of ascent, coded by sex and weight status, twice a week between 08:00 and 09:59. At baseline, the overweight chose stairs less than normal weight individuals. The multi-component campaign targeting weight control reversed this bias, increasing stair climbing only in overweight individuals. The specificity of the effect confirms the appeal of this lifestyle activity for the overweight. The discussion focuses on how intentions to control weight may be converted into behaviour.

Spaceborne radar interferometry for coastal DEM construction

USGS Publications Warehouse

Hong, S.-H.; Lee, C.-W.; Won, J.-S.; Kwoun, Oh-Ig; Lu, Z.

2005-01-01

Topographic features in coastal regions including tidal flats change more significantly than landmass, and are characterized by extremely low slopes. High precision DEMs are required to monitor dynamic changes in coastal topography. It is difficult to obtain coherent interferometric SAR pairs especially over tidal flats mainly because of variation of tidal conditions. Here we focus on i) coherence of multi-pass ERS SAR interferometric pairs and ii) DEM construction from ERS-ENVISAT pairs. Coherences of multi-pass ERS interferograms were good enough to construct DEM under favorable tidal conditions. Coherence in sand dominant area was generally higher than that in muddy surface. The coarse grained coastal areas are favorable for multi-pass interferometry. Utilization of ERS-ENVISAT interferometric pairs is taken a growing interest. We carried out investigation using a cross-interferometric pair with a normal baseline of about 1.3 km, a 30 minutes temporal separation and the height sensitivity of about 6 meters. Preliminary results of ERS-ENVISAT interferometry were not successful due to baseline and unfavorable scattering conditions. ?? 2005 IEEE.

Self-adaptive multi-objective harmony search for optimal design of water distribution networks

NASA Astrophysics Data System (ADS)

Choi, Young Hwan; Lee, Ho Min; Yoo, Do Guen; Kim, Joong Hoon

2017-11-01

In multi-objective optimization computing, it is important to assign suitable parameters to each optimization problem to obtain better solutions. In this study, a self-adaptive multi-objective harmony search (SaMOHS) algorithm is developed to apply the parameter-setting-free technique, which is an example of a self-adaptive methodology. The SaMOHS algorithm attempts to remove some of the inconvenience from parameter setting and selects the most adaptive parameters during the iterative solution search process. To verify the proposed algorithm, an optimal least cost water distribution network design problem is applied to three different target networks. The results are compared with other well-known algorithms such as multi-objective harmony search and the non-dominated sorting genetic algorithm-II. The efficiency of the proposed algorithm is quantified by suitable performance indices. The results indicate that SaMOHS can be efficiently applied to the search for Pareto-optimal solutions in a multi-objective solution space.

An enhanced multi-view vertical line locus matching algorithm of object space ground primitives based on positioning consistency for aerial and space images

NASA Astrophysics Data System (ADS)

Zhang, Ka; Sheng, Yehua; Wang, Meizhen; Fu, Suxia

2018-05-01

The traditional multi-view vertical line locus (TMVLL) matching method is an object-space-based method that is commonly used to directly acquire spatial 3D coordinates of ground objects in photogrammetry. However, the TMVLL method can only obtain one elevation and lacks an accurate means of validating the matching results. In this paper, we propose an enhanced multi-view vertical line locus (EMVLL) matching algorithm based on positioning consistency for aerial or space images. The algorithm involves three components: confirming candidate pixels of the ground primitive in the base image, multi-view image matching based on the object space constraints for all candidate pixels, and validating the consistency of the object space coordinates with the multi-view matching result. The proposed algorithm was tested using actual aerial images and space images. Experimental results show that the EMVLL method successfully solves the problems associated with the TMVLL method, and has greater reliability, accuracy and computing efficiency.

Effect of Escitalopram on Hot Flash Interference: A Randomized, Controlled Trial

PubMed Central

Carpenter, Janet S.; Guthrie, Katherine A.; Larson, Joseph C.; Freeman, Ellen W.; Joffe, Hadine; Reed, Susan D.; Ensrud, Kristine E.; LaCroix, Andrea Z.

2012-01-01

Objectives To estimate the effect of escitalopram 10–20 mg/day versus placebo for reducing hot flash interference in daily life and understand correlates and predictors of reductions in hot flash interference, a key measure of quality of life. Design Multi-site, randomized, double-blind, placebo-controlled clinical trial. Patients 205 midlife women (46% African-American) who met criteria participated. Setting MsFLASH clinical sites in Boston, Indianapolis, Oakland, and Philadelphia. Intervention After baseline, women were randomized to 1 pill of escitalopram 10 mg/day (n=104) or placebo (n=101) with follow-up at 4- and 8-weeks. At week 4, those not achieving 50% fewer hot flashes were increased to 2 pills daily (20 mg/day or 2 placebo pills). Main outcome measures The Hot Flash Related Daily Interference Scale; Correlates were variables from hot flash diaries; Predictors were baseline demographics, clinical variables, depression, anxiety, sleep quality, and hot flashes. Results Compared to placebo, escitalopram significantly reduced hot flash interference by 6.0 points at week 4 and 3.4 points at week 8 more than placebo (p=0.012). Reductions in hot flash interference correlated with changes in hot flash diary variables. However, baseline variables did not significantly predict reductions in hot flash interference. Conclusions Escitalopram 10–20mg/day for 8 weeks improves women’s quality of life and this benefit did not vary by demographic, clinical, mood, sleep, or hot flash variables. PMID:22480818

SU-F-R-46: Predicting Distant Failure in Lung SBRT Using Multi-Objective Radiomics Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, Z; Folkert, M; Iyengar, P

2016-06-15

Purpose: To predict distant failure in lung stereotactic body radiation therapy (SBRT) in early stage non-small cell lung cancer (NSCLC) by using a new multi-objective radiomics model. Methods: Currently, most available radiomics models use the overall accuracy as the objective function. However, due to data imbalance, a single object may not reflect the performance of a predictive model. Therefore, we developed a multi-objective radiomics model which considers both sensitivity and specificity as the objective functions simultaneously. The new model is used to predict distant failure in lung SBRT using 52 patients treated at our institute. Quantitative imaging features of PETmore » and CT as well as clinical parameters are utilized to build the predictive model. Image features include intensity features (9), textural features (12) and geometric features (8). Clinical parameters for each patient include demographic parameters (4), tumor characteristics (8), treatment faction schemes (4) and pretreatment medicines (6). The modelling procedure consists of two steps: extracting features from segmented tumors in PET and CT; and selecting features and training model parameters based on multi-objective. Support Vector Machine (SVM) is used as the predictive model, while a nondominated sorting-based multi-objective evolutionary computation algorithm II (NSGA-II) is used for solving the multi-objective optimization. Results: The accuracy for PET, clinical, CT, PET+clinical, PET+CT, CT+clinical, PET+CT+clinical are 71.15%, 84.62%, 84.62%, 85.54%, 82.69%, 84.62%, 86.54%, respectively. The sensitivities for the above seven combinations are 41.76%, 58.33%, 50.00%, 50.00%, 41.67%, 41.67%, 58.33%, while the specificities are 80.00%, 92.50%, 90.00%, 97.50%, 92.50%, 97.50%, 97.50%. Conclusion: A new multi-objective radiomics model for predicting distant failure in NSCLC treated with SBRT was developed. The experimental results show that the best performance can be obtained by combining all features.« less

Uncertainty-Based Multi-Objective Optimization of Groundwater Remediation Design

NASA Astrophysics Data System (ADS)

Singh, A.; Minsker, B.

2003-12-01

Management of groundwater contamination is a cost-intensive undertaking filled with conflicting objectives and substantial uncertainty. A critical source of this uncertainty in groundwater remediation design problems comes from the hydraulic conductivity values for the aquifer, upon which the prediction of flow and transport of contaminants are dependent. For a remediation solution to be reliable in practice it is important that it is robust over the potential error in the model predictions. This work focuses on incorporating such uncertainty within a multi-objective optimization framework, to get reliable as well as Pareto optimal solutions. Previous research has shown that small amounts of sampling within a single-objective genetic algorithm can produce highly reliable solutions. However with multiple objectives the noise can interfere with the basic operations of a multi-objective solver, such as determining non-domination of individuals, diversity preservation, and elitism. This work proposes several approaches to improve the performance of noisy multi-objective solvers. These include a simple averaging approach, taking samples across the population (which we call extended averaging), and a stochastic optimization approach. All the approaches are tested on standard multi-objective benchmark problems and a hypothetical groundwater remediation case-study; the best-performing approach is then tested on a field-scale case at Umatilla Army Depot.

The Worst-Case Weighted Multi-Objective Game with an Application to Supply Chain Competitions

PubMed Central

Qu, Shaojian; Ji, Ying

2016-01-01

In this paper, we propose a worst-case weighted approach to the multi-objective n-person non-zero sum game model where each player has more than one competing objective. Our “worst-case weighted multi-objective game” model supposes that each player has a set of weights to its objectives and wishes to minimize its maximum weighted sum objectives where the maximization is with respect to the set of weights. This new model gives rise to a new Pareto Nash equilibrium concept, which we call “robust-weighted Nash equilibrium”. We prove that the robust-weighted Nash equilibria are guaranteed to exist even when the weight sets are unbounded. For the worst-case weighted multi-objective game with the weight sets of players all given as polytope, we show that a robust-weighted Nash equilibrium can be obtained by solving a mathematical program with equilibrium constraints (MPEC). For an application, we illustrate the usefulness of the worst-case weighted multi-objective game to a supply chain risk management problem under demand uncertainty. By the comparison with the existed weighted approach, we show that our method is more robust and can be more efficiently used for the real-world applications. PMID:26820512

Multi-objective decision-making model based on CBM for an aircraft fleet

NASA Astrophysics Data System (ADS)

Luo, Bin; Lin, Lin

2018-04-01

Modern production management patterns, in which multi-unit (e.g., a fleet of aircrafts) are managed in a holistic manner, have brought new challenges for multi-unit maintenance decision making. To schedule a good maintenance plan, not only does the individual machine maintenance have to be considered, but also the maintenance of the other individuals have to be taken into account. Since most condition-based maintenance researches for aircraft focused on solely reducing maintenance cost or maximizing the availability of single aircraft, as well as considering that seldom researches concentrated on both the two objectives: minimizing cost and maximizing the availability of a fleet (total number of available aircraft in fleet), a multi-objective decision-making model based on condition-based maintenance concentrated both on the above two objectives is established. Furthermore, in consideration of the decision maker may prefer providing the final optimal result in the form of discrete intervals instead of a set of points (non-dominated solutions) in real decision-making problem, a novel multi-objective optimization method based on support vector regression is proposed to solve the above multi-objective decision-making model. Finally, a case study regarding a fleet is conducted, with the results proving that the approach efficiently generates outcomes that meet the schedule requirements.

Airborne Multi-Spectral Minefield Survey

DTIC Science & Technology

2005-05-01

Swedish Defence Research Agency), GEOSPACE (Austria), GTD ( Ingenieria de Sistemas y Software Industrial, Spain), IMEC (Ineruniversity MicroElectronic...RTO-MP-SET-092 18 - 1 UNCLASSIFIED/UNLIMITED UNCLASSIFIED/UNLIMITED Airborne Multi-Spectral Minefield Survey Dirk-Jan de Lange, Eric den...actions is the severe lack of baseline information. To respond to this in a rapid way, cost-efficient data acquisition methods are a key issue. de

Recalibrating Baseline Evidence in Burundi, Malawi, Senegal and Uganda: Exploring the Potential of Multi-Site, National-Level Stakeholder Engagement in Participatory Evaluation

ERIC Educational Resources Information Center

Edge, Karen; Marphatia, Akanksha A.

2015-01-01

This paper details our collaborative work on the Improving Learning Outcomes in Primary Schools (ILOPS) project in Burundi, Malawi, Uganda and Senegal. ILOPS set out to establish an innovative template for multi-stakeholder, multinational participatory evaluation (PE) and examine the fundamental roles, relationships and evidence that underpin the…

Analytic hierarchy process-based approach for selecting a Pareto-optimal solution of a multi-objective, multi-site supply-chain planning problem

NASA Astrophysics Data System (ADS)

Ayadi, Omar; Felfel, Houssem; Masmoudi, Faouzi

2017-07-01

The current manufacturing environment has changed from traditional single-plant to multi-site supply chain where multiple plants are serving customer demands. In this article, a tactical multi-objective, multi-period, multi-product, multi-site supply-chain planning problem is proposed. A corresponding optimization model aiming to simultaneously minimize the total cost, maximize product quality and maximize the customer satisfaction demand level is developed. The proposed solution approach yields to a front of Pareto-optimal solutions that represents the trade-offs among the different objectives. Subsequently, the analytic hierarchy process method is applied to select the best Pareto-optimal solution according to the preferences of the decision maker. The robustness of the solutions and the proposed approach are discussed based on a sensitivity analysis and an application to a real case from the textile and apparel industry.

A data set for evaluating the performance of multi-class multi-object video tracking

NASA Astrophysics Data System (ADS)

Chakraborty, Avishek; Stamatescu, Victor; Wong, Sebastien C.; Wigley, Grant; Kearney, David

2017-05-01

One of the challenges in evaluating multi-object video detection, tracking and classification systems is having publically available data sets with which to compare different systems. However, the measures of performance for tracking and classification are different. Data sets that are suitable for evaluating tracking systems may not be appropriate for classification. Tracking video data sets typically only have ground truth track IDs, while classification video data sets only have ground truth class-label IDs. The former identifies the same object over multiple frames, while the latter identifies the type of object in individual frames. This paper describes an advancement of the ground truth meta-data for the DARPA Neovision2 Tower data set to allow both the evaluation of tracking and classification. The ground truth data sets presented in this paper contain unique object IDs across 5 different classes of object (Car, Bus, Truck, Person, Cyclist) for 24 videos of 871 image frames each. In addition to the object IDs and class labels, the ground truth data also contains the original bounding box coordinates together with new bounding boxes in instances where un-annotated objects were present. The unique IDs are maintained during occlusions between multiple objects or when objects re-enter the field of view. This will provide: a solid foundation for evaluating the performance of multi-object tracking of different types of objects, a straightforward comparison of tracking system performance using the standard Multi Object Tracking (MOT) framework, and classification performance using the Neovision2 metrics. These data have been hosted publically.

The Three-body System δ Circini

NASA Astrophysics Data System (ADS)

Mayer, Pavel; Harmanec, Petr; Sana, Hugues; Le Bouquin, Jean-Baptiste

2014-12-01

Delta Cir is known as an O7.5 III eclipsing and spectroscopic binary with an eccentric orbit. Penny et al. discovered the presence of a third component in the IUE spectra. The eclipsing binary and the third body revolve around a common center of gravity with a period of 1644 days in an eccentric orbit with a semimajor axis of 10 AU. We demonstrate the presence of apsidal-line rotation with a period of ≈141 yr, which is considerably longer than its theoretically predicted value, based on the published radii of the binary components derived from the Hipparchos H p light curve. However, our new solution of the same light curve resulted in smaller radii and better agreement between the observed and predicted period of the apsidal-line advance. There are indications that the third body is a binary. The object was resolved by VLTI using the PIONIER combiner; in 2012 June, the separation was 3.78 mas with magnitude difference in the H region 1.ͫ75. This result means that (assuming a distance of 770 pc) the inclination of the long orbit is 87.°7. Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under programs ID 65.N-0577, 67.B-0504, 074D-0300, 178.D-0361, 182.D-0356, 083.D-0589, 185.D-0056, 086.D-0997, and 087D-0946.

A multi-objective programming model for assessment the GHG emissions in MSW management

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mavrotas, George, E-mail: mavrotas@chemeng.ntua.gr; Skoulaxinou, Sotiria; Gakis, Nikos

2013-09-15

Highlights: • The multi-objective multi-period optimization model. • The solution approach for the generation of the Pareto front with mathematical programming. • The very detailed description of the model (decision variables, parameters, equations). • The use of IPCC 2006 guidelines for landfill emissions (first order decay model) in the mathematical programming formulation. - Abstract: In this study a multi-objective mathematical programming model is developed for taking into account GHG emissions for Municipal Solid Waste (MSW) management. Mathematical programming models are often used for structure, design and operational optimization of various systems (energy, supply chain, processes, etc.). The last twenty yearsmore » they are used all the more often in Municipal Solid Waste (MSW) management in order to provide optimal solutions with the cost objective being the usual driver of the optimization. In our work we consider the GHG emissions as an additional criterion, aiming at a multi-objective approach. The Pareto front (Cost vs. GHG emissions) of the system is generated using an appropriate multi-objective method. This information is essential to the decision maker because he can explore the trade-offs in the Pareto curve and select his most preferred among the Pareto optimal solutions. In the present work a detailed multi-objective, multi-period mathematical programming model is developed in order to describe the waste management problem. Apart from the bi-objective approach, the major innovations of the model are (1) the detailed modeling considering 34 materials and 42 technologies, (2) the detailed calculation of the energy content of the various streams based on the detailed material balances, and (3) the incorporation of the IPCC guidelines for the CH{sub 4} generated in the landfills (first order decay model). The equations of the model are described in full detail. Finally, the whole approach is illustrated with a case study referring to the application of the model in a Greek region.« less

Fabrication of a 20.5-inch-diameter segmented silicon annular optic prototype for the ROMA program

NASA Astrophysics Data System (ADS)

Hassell, Frank R.; Groark, Frank M.

1995-10-01

Recent advancements in single crystal silicon material science and fabrication capabilities and very low absorption (VLA) multi-layer dielectric coating technology have led to the development of uncooled, large aperture, high power mirrors for high energy laser (HEL) systems. Based on this success, a segmented single-crystal silicon substrate concept has been selected as the baseline fabrication approach for uncooled 1.2 meter diameter resonator annular optics for the Alpha space based high energy laser. The objective of this Resonator Optics Materials Assessment (ROMA) task was to demonstrate all of the key fabrication processes required to fabricate the full sized annular optics for the Alpha space based high energy laser. This paper documents the fabrication of a half-scale annular optic prototype (AOP) of the Alpha laser rear cone.

A 6-year follow-up of a large European cohort of children with attention-deficit/hyperactivity disorder-combined subtype: outcomes in late adolescence and young adulthood.

PubMed

van Lieshout, Marloes; Luman, Marjolein; Twisk, Jos W R; van Ewijk, Hanneke; Groenman, Annabeth P; Thissen, Andrieke J A M; Faraone, Stephen V; Heslenfeld, Dirk J; Hartman, Catharina A; Hoekstra, Pieter J; Franke, Barbara; Buitelaar, Jan K; Rommelse, Nanda N J; Oosterlaan, Jaap

2016-09-01

There are very few studies on the long-term outcome of children and adolescents with ADHD-combined type in Europe. The objective of the present study is to assess the 6-year outcome (including pharmacological treatment) of a large cohort of participants with ADHD-combined type (N = 347, mean age 11.4 years) in late adolescence and early adulthood. At study entry and follow-up (mean age 17.4 years), participants were comprehensively assessed on ADHD and comorbid disorders by structured psychiatric interviews and multi-informant questionnaires. Overall functioning was assessed by the Children's Global Assessment Scale. The retention rate was 75.6 %. The majority of participants (86.5 %) persisted in a DSM-5 ADHD diagnosis, 8.4 % had a subthreshold diagnosis, and 5.1 % remitted from the disorder at follow-up. Comorbidities decreased strongly; oppositional defiant disorder: 58 > 31 %, conduct disorder: 19 > 7 %. At follow-up, mood- and anxiety disorders were virtually non-existent following strict criteria (1-3 %). Percentage of children having had pharmacological treatment at any time increased from 79 to 91 %. On the Children's Global Assessment Scale, 48.5 % of participants were still functionally impaired at follow-up. Parental ADHD, higher ADHD symptom severity at baseline and higher parent-reported impairment at baseline positively predicted current ADHD symptom severity (R (2) = 20.9 %). Younger baseline age, higher ADHD symptom severity at baseline and higher parent-reported impairment at baseline were positively associated with poorer overall functioning (R (2) = 17.8 %). Pharmacological treatment had no (beneficial) impact on either ADHD symptom severity or overall functioning. Results confirm that ADHD is largely persistent into late adolescence with severity and family history for the disorder as important risk factors.

Multi-Objective Hybrid Optimal Control for Multiple-Flyby Interplanetary Mission Design Using Chemical Propulsion

NASA Technical Reports Server (NTRS)

Englander, Jacob; Vavrina, Matthew

2015-01-01

The customer (scientist or project manager) most often does not want just one point solution to the mission design problem Instead, an exploration of a multi-objective trade space is required. For a typical main-belt asteroid mission the customer might wish to see the trade-space of: Launch date vs. Flight time vs. Deliverable mass, while varying the destination asteroid, planetary flybys, launch year, etcetera. To address this question we use a multi-objective discrete outer-loop which defines many single objective real-valued inner-loop problems.

Hydro-environmental management of groundwater resources: A fuzzy-based multi-objective compromise approach

NASA Astrophysics Data System (ADS)

Alizadeh, Mohammad Reza; Nikoo, Mohammad Reza; Rakhshandehroo, Gholam Reza

2017-08-01

Sustainable management of water resources necessitates close attention to social, economic and environmental aspects such as water quality and quantity concerns and potential conflicts. This study presents a new fuzzy-based multi-objective compromise methodology to determine the socio-optimal and sustainable policies for hydro-environmental management of groundwater resources, which simultaneously considers the conflicts and negotiation of involved stakeholders, uncertainties in decision makers' preferences, existing uncertainties in the groundwater parameters and groundwater quality and quantity issues. The fuzzy multi-objective simulation-optimization model is developed based on qualitative and quantitative groundwater simulation model (MODFLOW and MT3D), multi-objective optimization model (NSGA-II), Monte Carlo analysis and Fuzzy Transformation Method (FTM). Best compromise solutions (best management policies) on trade-off curves are determined using four different Fuzzy Social Choice (FSC) methods. Finally, a unanimity fallback bargaining method is utilized to suggest the most preferred FSC method. Kavar-Maharloo aquifer system in Fars, Iran, as a typical multi-stakeholder multi-objective real-world problem is considered to verify the proposed methodology. Results showed an effective performance of the framework for determining the most sustainable allocation policy in groundwater resource management.

Sugar-sweetened beverage consumption and the progression of chronic kidney disease in the Multi-Ethnic Study of Atherosclerosis (MESA)123

PubMed Central

Katz, Ronit; He, Ka; Shoham, David A; Burke, Gregory L; Klemmer, Philip J

2009-01-01

Background: Recent studies have examined sugar-sweetened soda consumption in relation to early markers of kidney disease, but to date there have been no investigations of whether sugar-sweetened beverage consumption affects preexistent chronic kidney disease (CKD). Objective: This prospective cohort study of 447 participants in the Multi-Ethnic Study of Atherosclerosis (MESA) with preexistent CKD examined the association between sugar-sweetened beverage consumption (<1 drink/wk, 1–6 drinks/wk, and ≥1 drink/d) and progression of CKD. Design: β-Coefficients for continuous outcomes of changes in estimated glomerular filtration rate (eGFR) and urinary albumin to creatinine ratio (UACR) were calculated by using linear regression. Odds ratios for binary outcomes of accelerated decline in eGFR, defined as >2 mL · min−1 · 1.73 m−2 per year, and clinically significant progression of albuminuria (defined as attainment of UACR ≥30 mg/g for participants without microalbuminuria at visit 1 or a ≥25% increase in UACR for participants with baseline microalbuminuria) were evaluated by using logistic regression. Results: The mean (±SD) baseline eGFR was 52 ± 6 mL · min−1 · 1.73 m−2 per year, and median baseline UACR was 6.3 mg/g (interquartile range: 3.5–17.6). Univariate and multivariate analyses showed no association between sugar-sweetened beverage consumption and rate of eGFR decline or changes in urinary albumin to creatinine ratio. The multivariate odds ratios comparing participants who drank ≥1 sugary beverage daily with those who drank ≤1 beverage weekly were 0.62 (95% CI: 0.27, 1.41) for accelerated eGFR decline and 1.51 (95% CI: 0.49, 4.62) for clinically significant progression of albuminuria. Conclusion: A higher consumption of sugar-sweetened beverages was not associated with disease progression, on the basis of either eGFR or the urinary albumin to creatinine ratio, in MESA participants with preexistent CKD. PMID:19740973

Antecedent Longitudinal Changes in Body Mass Index are associated with Diurnal Cortisol Curve Features: The Multi-Ethnic Study of Atherosclerosis

PubMed Central

Joseph, Joshua J.; Wang, Xu; Roux, Ana V. Diez; Sanchez, Brisa N.; Seeman, Teresa E.; Needham, Belinda L.; Golden, Sherita Hill

2016-01-01

Context Prior studies have shown a cross-sectional association between body mass index (BMI) and salivary diurnal cortisol profile features (cortisol features); however, to our knowledge prior population-based studies have not examined the longitudinal association of body-mass index (BMI) with cortisol features. Objective To examine the association of (1) prior annual BMI percent change over 7 years with cortisol features, (2) baseline cortisol features with subsequent change in BMI over 6 years and (3) the association of change in cortisol features with change in BMI over 6 years. Design Longitudinal study Setting Multi-Ethnic Study of Atherosclerosis (MESA) Stress I & II Studies (2004-2006 & 2010-2012) Participants 1,685 ethnically diverse men and women attended either MESA Stress exam (mean age 65 ± 10 years at MESA Stress I; mean age 69 ± 9 years at MESA Stress II). Outcome Measures Log-transformed cortisol features including wake-up cortisol, cortisol awakening response, early decline slope (30 minutes to 2 hours post-awakening), late decline slope (2 hours post-awakening to bedtime), bedtime, and total area under the curve (AUC) cortisol. Results Over 7 years, following multivariable adjustment, (1) a 1% higher prior annual BMI % increase was associated with a 2.9% (95% CI: −5.0%, −0.8%) and 3.0% (95% CI: −4.7%, −1.4%) lower current wake-up and total AUC cortisol, respectively; (2) there was no significant association between baseline cortisol features and subsequent change in BMI and (3) among participants with BMI ≥ 30 kg/m2, flattening of the late decline slope was associated with increases in BMI (every 1-unit increase late decline slope were associated with a 12.9% increase (95%CI: −1%, 26.8%) in BMI, respectively). Conclusions We found a significant association between prior annual BMI % change and cortisol features, but no significant association between baseline cortisol features and subsequent change in BMI. In participants with obesity increases in BMI were associated with less pronounced declined. Collectively, our results suggest that greater adiposity may lead to a blunted diurnal cortisol profile. PMID:28183457

Associations between Aspirin and other non-steroidal anti-inflammatory drugs and aortic valve or coronary artery calcification: The Multi-Ethnic Study of Atherosclerosis and the Heinz Nixdorf Recall Study

PubMed Central

Delaney, Joseph A; Lehmann, Nils; Jöckel, Karl-Heinz; Elmariah, Sammy; Psaty, Bruce M; Mahabadi, Amir; Budoff, Matt; Kronmal, Richard A; Nasir, Khurram; O’Brien, Kevin D.; Möhlenkamp, Stefan; Moebus, Susanne; Dragano, Nico; Winterstein, Almut; Erbel, Raimund; Kälsch, Hagen

2013-01-01

Background The association between non-steroidal anti-inflammatory drugs (NSAIDs) and the incidence of valvular and arterial calcification is not well established despite known associations between these drugs and cardiovascular events. Objective To compare the association between the baseline use of aspirin with other NSAID class medications with the incidence and prevalence of aortic valve calcification (AVC) and coronary artery calcium (CAC). Methods The relationship of NSAID use to AVC and CAC detected by computed tomography was assessed in 6,814 participants within the Multi-Ethnic Study of Atherosclerosis (MESA) using regression modeling. Results were adjusted for age, sex, ethnicity, study site, anti-hypertensive medication use, education, income, health insurance status, diabetes, smoking, exercise, body mass index, blood pressure, serum lipids, inflammatory markers, fasting glucose, statin medication use, and a simple diet score. Medication use was assessed by medication inventory at baseline which includes the use of non-prescription NSAIDs. MESA collects information on both incident and prevalent calcification. The 4,814 participants of the Heinz Nixdorf Recall (HNR) Study, a German prospective cohort study with similar measures of calcification, were included in this analysis to enable replication. Results Mean age of the MESA participants was 62 years (51% female). After adjustment for possible confounding factors, a possible association between aspirin use and incident AVC (Relative Risk(RR): 1.60; 95%Confidence Interval (CI): 1.19–2.15) did not replicate in the HNR cohort (RR: 1.06; 95%CI: 0.87–1.28). There was no significant association between aspirin use and incident CAC in the MESA cohort (RR 1.08; 95%CI: 0.91–1.29) or in the HNR cohort (RR 1.24; 95%CI: 0.87–1.77). Non-aspirin NSAID use was not associated with either AVC or CAC in either cohort. There were no associations between regular cardiac dose aspirin and incident calcification in either cohort. Conclusion Baseline NSAID use, as assessed by medication inventory, appears to have no protective effect regarding the onset of calcification in either coronary arteries or aortic valves. PMID:23880181

Multi-object Detection and Discrimination Algorithms

DTIC Science & Technology

2015-03-26

with  an   algorithm  similar  to  a  depth-­‐first   search .   This  stage  of  the   algorithm  is  O(CN).  From...Multi-object Detection and Discrimination Algorithms This document contains an overview of research and work performed and published at the University...of Florida from October 1, 2009 to October 31, 2013 pertaining to proposal 57306CS: Multi-object Detection and Discrimination Algorithms

Is bioresorbable vascular scaffold acute recoil affected by baseline renal function and scaffold selection?

PubMed

Gunes, Haci Murat; Yılmaz, Filiz Kizilirmak; Gokdeniz, Tayyar; Demir, Gultekin Gunhan; Guler, Ekrem; Guler, Gamze Babur; Karaca, Oğuz; Cakal, Beytullah; İbişoğlu, Ersin; Boztosun, Bilal

2016-12-01

The aim of the present study was to investigate the relationship between glomerular filtration rate (GFR) and acute post-scaffold recoil (PSR) in patients undergoing bioresorbable scaffold (BVS) implantation. We included 130 patients who underwent everolimus-eluting BVS device (Absorb BVS; Abbott Vascular, Santa Clara, CA, USA) or the novolimus-eluting BVS device (Elixir Medical Corporation) implantations for single or multi-vessel disease. Clinical, angiographic variables and procedural characteristics were defined and pre-procedural GFR was calculated for each patient. Post-procedural angiographic parameters of each patient were analyzed. Primary objective of the study was to evaluate the effect of GFR on angiographic outcomes after BVS implantation while secondary objective was to compare post-procedural angiographic results between the two BVS device groups. Baseline clinical characteristics and angiographic parameters were similar between the two BVS groups. Post-procedural angiographic analysis revealed significantly lower PSR in the DESolve group than the Absorb group (0.10±0.04 vs. 0.13±0.05, p: 0.003). When PSR in the whole study population was evaluated, it was positively correlated with age, tortuosity , calcification and PBR as there was a negative correlation between GFR. Besides GFR were found to be independent predictors for PSR in all groups and the whole study population. In patients undergoing BVS implantation, pre-procedural low GFR is associated with increased post-procedural PSR. Calcification, age, PBR, dyslipidemia and tortuosity are other independent risk factors for PSR. DESolve has lower PSR when compared with Absorb. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Chronicle of a Death Foretold

NASA Astrophysics Data System (ADS)

2007-05-01

Using ESO's VLTI on Cerro Paranal and the VLBA facility operated by NRAO, an international team of astronomers has made what is arguably the most detailed study of the environment of a pulsating red giant star. They performed, for the first time, a series of coordinated observations of three separate layers within the star's tenuous outer envelope: the molecular shell, the dust shell, and the maser shell, leading to significant progress in our understanding of the mechanism of how, before dying, evolved stars lose mass and return it to the interstellar medium. S Orionis (S Ori) belongs to the class of Mira-type variable stars. It is a solar-mass star that, as will be the fate of our Sun in 5 billion years, is nearing its gloomy end as a white dwarf. Mira stars are very large and lose huge amounts of matter. Every year, S Ori ejects as much as the equivalent of Earth's mass into the cosmos. ESO PR Photo 25a/07 ESO PR Photo 25a/07 Evolution of the Mira-type Star S Orionis "Because we are all stardust, studying the phases in the life of a star when processed matter is sent back to the interstellar medium to be used for the next generation of stars, planets... and humans, is very important," said Markus Wittkowski, lead author of the paper reporting the results. A star such as the Sun will lose between a third and half of its mass during the Mira phase. S Ori pulsates with a period of 420 days. In the course of its cycle, it changes its brightness by a factor of the order of 500, while its diameter varies by about 20%. Although such stars are enormous - they are typically larger than the current Sun by a factor of a few hundred, i.e. they encompass the orbit of the Earth around the Sun - they are also distant and to peer into their deep envelopes requires very high resolution. This can only be achieved with interferometric techniques. ESO PR Photo 25b/07 ESO PR Photo 25b/07 Structure of S Ori (Artist's Impression) "Astronomers are like medical doctors, who use various instruments to examine different parts of the human body," said co-author David Boboltz. "While the mouth can be checked with a simple light, a stethoscope is required to listen to the heart beat. Similarly the heart of the star can be observed in the optical, the molecular and dust layers can be studied in the infrared and the maser emission can be probed with radio instruments. Only the combination of the three gives us a more complete picture of the star and its envelope." The maser emission comes from silicon monoxide (SiO) molecules and can be used to image and track the motion of gas clouds in the stellar envelope roughly 10 times the size of the Sun. The astronomers observed S Ori with two of the largest interferometric facilities available: the ESO Very Large Telescope Interferometer (VLTI) at Paranal, observing in the near- and mid-infrared, and the NRAO-operated Very Long Baseline Array (VLBA), that takes measurements in the radio wave domain. Because the star's luminosity changes periodically, the astronomers observed it simultaneously with both instruments, at several different epochs. The first epoch occurred close to the stellar minimum luminosity and the last just after the maximum on the next cycle. ESO PR Photo 25c/07 ESO PR Photo 25c/07 S Ori to Scale (Artist's Impression) The astronomers found the star's diameter to vary between 7.9 milliarcseconds and 9.7 milliarcseconds. At the distance of S Ori, this corresponds to a change of the radius from about 1.9 to 2.3 times the distance between the Earth and the Sun, or between 400 and 500 solar radii! As if such sizes were not enough, the inner dust shell is found to be about twice as big. The maser spots, which also form at about twice the radius of the star, show the typical structure of partial to full rings with a clumpy distribution. Their velocities indicate that the gas is expanding radially, moving away at a speed of about 10 km/s. The multi-wavelength analysis indicates that near the minimum there is more dust production and mass ejection: in these phases indeed the amount of dust is significantly higher than in the others. After this intense matter production and ejection the star continues its pulsation and when it reaches the maximum luminosity, it displays a much more expanded dust shell. This clearly supports a strong connection between the Mira pulsation and the dust production and expulsion. Furthermore, the astronomers found that grains of aluminum oxide - also called corundum - constitute most of S Ori's dust shell: the grain size is estimated to be of the order of 10 millionths of a centimetre, that is one thousand times smaller than the diameter of a human hair. "We know one chapter of the secret life of a Mira star, but much more can be learned in the near future, when we add near-infrared interferometry with the AMBER instrument on the VLTI to our (already broad) observational approach," said Wittkowski. More Information The research presented here is reported in a paper in press in the journal Astronomy and Astrophysics ("The Mira variable S Ori: Relationships between the photosphere, molecular layer, dust shell, and SiO maser shell at 4 epochs", by M. Wittkowski et al.). It is available in PDF format from the publisher's web site. The team consists of Markus Wittkowski (ESO), David A. Boboltz (U.S. Naval Observatory, USA), Keiichi Ohnaka and Thomas Driebe (MPIfR Bonn, Germany), and Michael Scholz (University of Heidelberg, Germany and University of Sydney, Australia).

Evaluating the predictive power of multivariate tensor-based morphometry in Alzheimer's disease progression via convex fused sparse group Lasso

NASA Astrophysics Data System (ADS)

Tsao, Sinchai; Gajawelli, Niharika; Zhou, Jiayu; Shi, Jie; Ye, Jieping; Wang, Yalin; Lepore, Natasha

2014-03-01

Prediction of Alzheimers disease (AD) progression based on baseline measures allows us to understand disease progression and has implications in decisions concerning treatment strategy. To this end we combine a predictive multi-task machine learning method1 with novel MR-based multivariate morphometric surface map of the hippocampus2 to predict future cognitive scores of patients. Previous work by Zhou et al.1 has shown that a multi-task learning framework that performs prediction of all future time points (or tasks) simultaneously can be used to encode both sparsity as well as temporal smoothness. They showed that this can be used in predicting cognitive outcomes of Alzheimers Disease Neuroimaging Initiative (ADNI) subjects based on FreeSurfer-based baseline MRI features, MMSE score demographic information and ApoE status. Whilst volumetric information may hold generalized information on brain status, we hypothesized that hippocampus specific information may be more useful in predictive modeling of AD. To this end, we applied Shi et al.2s recently developed multivariate tensor-based (mTBM) parametric surface analysis method to extract features from the hippocampal surface. We show that by combining the power of the multi-task framework with the sensitivity of mTBM features of the hippocampus surface, we are able to improve significantly improve predictive performance of ADAS cognitive scores 6, 12, 24, 36 and 48 months from baseline.

Penalized likelihood and multi-objective spatial scans for the detection and inference of irregular clusters

PubMed Central

2010-01-01

Background Irregularly shaped spatial clusters are difficult to delineate. A cluster found by an algorithm often spreads through large portions of the map, impacting its geographical meaning. Penalized likelihood methods for Kulldorff's spatial scan statistics have been used to control the excessive freedom of the shape of clusters. Penalty functions based on cluster geometry and non-connectivity have been proposed recently. Another approach involves the use of a multi-objective algorithm to maximize two objectives: the spatial scan statistics and the geometric penalty function. Results & Discussion We present a novel scan statistic algorithm employing a function based on the graph topology to penalize the presence of under-populated disconnection nodes in candidate clusters, the disconnection nodes cohesion function. A disconnection node is defined as a region within a cluster, such that its removal disconnects the cluster. By applying this function, the most geographically meaningful clusters are sifted through the immense set of possible irregularly shaped candidate cluster solutions. To evaluate the statistical significance of solutions for multi-objective scans, a statistical approach based on the concept of attainment function is used. In this paper we compared different penalized likelihoods employing the geometric and non-connectivity regularity functions and the novel disconnection nodes cohesion function. We also build multi-objective scans using those three functions and compare them with the previous penalized likelihood scans. An application is presented using comprehensive state-wide data for Chagas' disease in puerperal women in Minas Gerais state, Brazil. Conclusions We show that, compared to the other single-objective algorithms, multi-objective scans present better performance, regarding power, sensitivity and positive predicted value. The multi-objective non-connectivity scan is faster and better suited for the detection of moderately irregularly shaped clusters. The multi-objective cohesion scan is most effective for the detection of highly irregularly shaped clusters. PMID:21034451

The convective photosphere of the red supergiant CE Tauri. I. VLTI/PIONIER H-band interferometric imaging

NASA Astrophysics Data System (ADS)

Montargès, M.; Norris, R.; Chiavassa, A.; Tessore, B.; Lèbre, A.; Baron, F.

2018-06-01

Context. Red supergiant stars are one of the latest stages in the evolution of massive stars. Their photospheric convection may play an important role in the launching mechanism of their mass loss; however, its characteristics and dynamics are still poorly constrained. Aims: By observing red supergiant stars with near infrared interferometry at different epochs, we expect to reveal the evolution of bright convective features on their stellar surface. Methods: We observed the M2Iab-Ib red supergiant star CE Tau with the VLTI/PIONIER instrument in the H band at two different epochs separated by one month. Results: We derive the angular diameter of the star and basic stellar parameters, and reconstruct two reliable images of its H-band photosphere. The contrast of the convective pattern of the reconstructed images is 5 ± 1% and 6 ± 1% for our two epochs of observation. Conclusions: The stellar photosphere shows few changes between the two epochs. The contrast of the convective pattern is below the average contrast variations obtained on 30 randomly chosen snapshots of the best matching 3D radiative hydrodynamics simulation: 23 ± 1% for the original simulation images and 16 ± 1% for the maps degraded to the reconstruction resolution. We offer two hypotheses to explain this observation. CE Tau may be experiencing a quiet convective activity episode or it could be a consequence of its warmer effective temperature (hence its smaller radius) compared to the simulation. Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere under ESO programs 298.D-5005(A) and 298.D-5005(B).Reconstructed images as FITS files and basic stellar parameters are available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/614/A12Animated gif of the two epochs is available at http://https://www.aanda.org

ESO Reflex: A Graphical Workflow Engine for Data Reduction

NASA Astrophysics Data System (ADS)

Hook, R.; Romaniello, M.; Péron, M.; Ballester, P.; Gabasch, A.; Izzo, C.; Ullgrén, M.; Maisala, S.; Oittinen, T.; Solin, O.; Savolainen, V.; Järveläinen, P.; Tyynelä, J.

2008-08-01

Sampo {http://www.eso.org/sampo} (Hook et al. 2005) is a project led by ESO and conducted by a software development team from Finland as an in-kind contribution to joining ESO. The goal is to assess the needs of the ESO community in the area of data reduction environments and to create pilot software products that illustrate critical steps along the road to a new system. Those prototypes will not only be used to validate concepts and understand requirements but will also be tools of immediate value for the community. Most of the raw data produced by ESO instruments can be reduced using CPL {http://www.eso.org/cpl} recipes: compiled C programs following an ESO standard and utilizing routines provided by the Common Pipeline Library. Currently reduction recipes are run in batch mode as part of the data flow system to generate the input to the ESO VLT/VLTI quality control process and are also made public for external users. Sampo has developed a prototype application called ESO Reflex {http://www.eso.org/sampo/reflex/} that integrates a graphical user interface and existing data reduction algorithms. ESO Reflex can invoke CPL-based recipes in a flexible way through a dedicated interface. ESO Reflex is based on the graphical workflow engine Taverna {http://taverna.sourceforge.net} that was originally developed by the UK eScience community, mostly for work in the life sciences. Workflows have been created so far for three VLT/VLTI instrument modes ( VIMOS/IFU {http://www.eso.org/instruments/vimos/}, FORS spectroscopy {http://www.eso.org/instruments/fors/} and AMBER {http://www.eso.org/instruments/amber/}), and the easy-to-use GUI allows the user to make changes to these or create workflows of their own. Python scripts and IDL procedures can be easily brought into workflows and a variety of visualisation and display options, including custom product inspection and validation steps, are available.

Robust Optimization and Sensitivity Analysis with Multi-Objective Genetic Algorithms: Single- and Multi-Disciplinary Applications

DTIC Science & Technology

2007-01-01

multi-disciplinary optimization with uncertainty. Robust optimization and sensitivity analysis is usually used when an optimization model has...formulation is introduced in Section 2.3. We briefly discuss several definitions used in the sensitivity analysis in Section 2.4. Following in...2.5. 2.4 SENSITIVITY ANALYSIS In this section, we discuss several definitions used in Chapter 5 for Multi-Objective Sensitivity Analysis . Inner

Multi-objective evolutionary algorithms for fuzzy classification in survival prediction.

PubMed

Jiménez, Fernando; Sánchez, Gracia; Juárez, José M

2014-03-01

This paper presents a novel rule-based fuzzy classification methodology for survival/mortality prediction in severe burnt patients. Due to the ethical aspects involved in this medical scenario, physicians tend not to accept a computer-based evaluation unless they understand why and how such a recommendation is given. Therefore, any fuzzy classifier model must be both accurate and interpretable. The proposed methodology is a three-step process: (1) multi-objective constrained optimization of a patient's data set, using Pareto-based elitist multi-objective evolutionary algorithms to maximize accuracy and minimize the complexity (number of rules) of classifiers, subject to interpretability constraints; this step produces a set of alternative (Pareto) classifiers; (2) linguistic labeling, which assigns a linguistic label to each fuzzy set of the classifiers; this step is essential to the interpretability of the classifiers; (3) decision making, whereby a classifier is chosen, if it is satisfactory, according to the preferences of the decision maker. If no classifier is satisfactory for the decision maker, the process starts again in step (1) with a different input parameter set. The performance of three multi-objective evolutionary algorithms, niched pre-selection multi-objective algorithm, elitist Pareto-based multi-objective evolutionary algorithm for diversity reinforcement (ENORA) and the non-dominated sorting genetic algorithm (NSGA-II), was tested using a patient's data set from an intensive care burn unit and a standard machine learning data set from an standard machine learning repository. The results are compared using the hypervolume multi-objective metric. Besides, the results have been compared with other non-evolutionary techniques and validated with a multi-objective cross-validation technique. Our proposal improves the classification rate obtained by other non-evolutionary techniques (decision trees, artificial neural networks, Naive Bayes, and case-based reasoning) obtaining with ENORA a classification rate of 0.9298, specificity of 0.9385, and sensitivity of 0.9364, with 14.2 interpretable fuzzy rules on average. Our proposal improves the accuracy and interpretability of the classifiers, compared with other non-evolutionary techniques. We also conclude that ENORA outperforms niched pre-selection and NSGA-II algorithms. Moreover, given that our multi-objective evolutionary methodology is non-combinational based on real parameter optimization, the time cost is significantly reduced compared with other evolutionary approaches existing in literature based on combinational optimization. Copyright © 2014 Elsevier B.V. All rights reserved.

A multi-resolution strategy for a multi-objective deformable image registration framework that accommodates large anatomical differences

NASA Astrophysics Data System (ADS)

Alderliesten, Tanja; Bosman, Peter A. N.; Sonke, Jan-Jakob; Bel, Arjan

2014-03-01

Currently, two major challenges dominate the field of deformable image registration. The first challenge is related to the tuning of the developed methods to specific problems (i.e. how to best combine different objectives such as similarity measure and transformation effort). This is one of the reasons why, despite significant progress, clinical implementation of such techniques has proven to be difficult. The second challenge is to account for large anatomical differences (e.g. large deformations, (dis)appearing structures) that occurred between image acquisitions. In this paper, we study a framework based on multi-objective optimization to improve registration robustness and to simplify tuning for specific applications. Within this framework we specifically consider the use of an advanced model-based evolutionary algorithm for optimization and a dual-dynamic transformation model (i.e. two "non-fixed" grids: one for the source- and one for the target image) to accommodate for large anatomical differences. The framework computes and presents multiple outcomes that represent efficient trade-offs between the different objectives (a so-called Pareto front). In image processing it is common practice, for reasons of robustness and accuracy, to use a multi-resolution strategy. This is, however, only well-established for single-objective registration methods. Here we describe how such a strategy can be realized for our multi-objective approach and compare its results with a single-resolution strategy. For this study we selected the case of prone-supine breast MRI registration. Results show that the well-known advantages of a multi-resolution strategy are successfully transferred to our multi-objective approach, resulting in superior (i.e. Pareto-dominating) outcomes.

Chance-constrained multi-objective optimization of groundwater remediation design at DNAPLs-contaminated sites using a multi-algorithm genetically adaptive method

NASA Astrophysics Data System (ADS)

Ouyang, Qi; Lu, Wenxi; Hou, Zeyu; Zhang, Yu; Li, Shuai; Luo, Jiannan

2017-05-01

In this paper, a multi-algorithm genetically adaptive multi-objective (AMALGAM) method is proposed as a multi-objective optimization solver. It was implemented in the multi-objective optimization of a groundwater remediation design at sites contaminated by dense non-aqueous phase liquids. In this study, there were two objectives: minimization of the total remediation cost, and minimization of the remediation time. A non-dominated sorting genetic algorithm II (NSGA-II) was adopted to compare with the proposed method. For efficiency, the time-consuming surfactant-enhanced aquifer remediation simulation model was replaced by a surrogate model constructed by a multi-gene genetic programming (MGGP) technique. Similarly, two other surrogate modeling methods-support vector regression (SVR) and Kriging (KRG)-were employed to make comparisons with MGGP. In addition, the surrogate-modeling uncertainty was incorporated in the optimization model by chance-constrained programming (CCP). The results showed that, for the problem considered in this study, (1) the solutions obtained by AMALGAM incurred less remediation cost and required less time than those of NSGA-II, indicating that AMALGAM outperformed NSGA-II. It was additionally shown that (2) the MGGP surrogate model was more accurate than SVR and KRG; and (3) the remediation cost and time increased with the confidence level, which can enable decision makers to make a suitable choice by considering the given budget, remediation time, and reliability.

Using MOEA with Redistribution and Consensus Branches to Infer Phylogenies.

PubMed

Min, Xiaoping; Zhang, Mouzhao; Yuan, Sisi; Ge, Shengxiang; Liu, Xiangrong; Zeng, Xiangxiang; Xia, Ningshao

2017-12-26

In recent years, to infer phylogenies, which are NP-hard problems, more and more research has focused on using metaheuristics. Maximum Parsimony and Maximum Likelihood are two effective ways to conduct inference. Based on these methods, which can also be considered as the optimal criteria for phylogenies, various kinds of multi-objective metaheuristics have been used to reconstruct phylogenies. However, combining these two time-consuming methods results in those multi-objective metaheuristics being slower than a single objective. Therefore, we propose a novel, multi-objective optimization algorithm, MOEA-RC, to accelerate the processes of rebuilding phylogenies using structural information of elites in current populations. We compare MOEA-RC with two representative multi-objective algorithms, MOEA/D and NAGA-II, and a non-consensus version of MOEA-RC on three real-world datasets. The result is, within a given number of iterations, MOEA-RC achieves better solutions than the other algorithms.

New Vistas Open with MIDI at the VLT Interferometer

NASA Astrophysics Data System (ADS)

2002-12-01

"First Fringes" in Mid-Infrared Spectral Region with Two Giant Telescopes Summary Following several weeks of around-the-clock work, a team of astronomers and engineers from Germany, the Netherlands, France and ESO [2] has successfully performed the first observations with the MID-Infrared interferometric instrument (MIDI), a new, extremely powerful instrument just installed in the underground laboratory of the VLT Interferometer (VLTI) at the Paranal Observatory (Chile). In the early morning of December 15, 2002, two of the 8.2 m VLT unit telescopes (ANTU and MELIPAL) were pointed towards the southern star eta Carinae and the two light beams were directed via the complex intervening optics system towards MIDI. After a few hours of tuning and optimization, strong and stable interferometric fringes were obtained, indicating that all VLTI components - from telescopes to the new instrument - were working together perfectly. Two more stars were observed before sunrise, further proving the stability of the entire system. The first observations with MIDI mark one more important step towards full and regular operation of the VLT Interferometer [3] . They are a result of five years of determined efforts within a concerted technology project, based on a close collaboration between ESO and several European research institutes (see below). Now opening great research vistas, they also represent several "firsts" in observational astrophysics, together amounting to a real breakthrough in the field of astronomical interferometry . New views at mid-infrared wavelengths : MIDI is sensitive to light of a wavelength near 10 µm, i.e., in the mid-infrared spectral region ("thermal infrared"). This provides rich opportunities to study a wide range of otherwise inaccessible, crucial astrophysical phenomena, e.g., the formation of planets in dusty disks around newborn stars and the innermost regions around black holes. However, it is a great technical challenge to perform mid-IR observations. This is first of all because the terrestrial atmosphere, the telescopes, their mounts and, not least, the complicated optics system needed to guide the beams the long way from the telescopes to the MIDI instrument all glow bright at mid-IR wavelengths. Thus, even the most luminous mid-IR stellar sources "drown" in this bright background, calling for highly refined observational methods and data reduction procedures. Fainter objects with large telescopes : This is the first time telescopes with mirrors as large as these have been used for mid-IR interferometry. The use of the VLT giants at Paranal now allows observing much fainter objects than before. Sharper images with Interferometry : The distance between ANTU and MELIPAL during these observations, 102 metres, is a new world record for interferometry at this wavelength. The achieved angular resolution is indeed the one theoretically possible with this instrumental configuration, about 0.01 arcsec, better than what has ever been achieved before from ground or space at this wavelength. MIDI is the first of two instruments that will be placed at the focus of the VLT Interferometer. It is a collaborative project between several European research institutes: * European Southern Observatory (ESO) * Max Planck Institut für Astronomie (MPIA) (Heidelberg, Germany) * Netherlands Graduate School for Astronomy (NOVA) (Leiden, The Netherlands) * Department of Astronomy - Leiden Observatory (The Netherlands) * Kapteyn Astronomical Institute (Groningen, The Netherlands) * Astronomical Institute, Utrecht University (The Netherlands) * Netherlands Foundation for Research in Astronomy (NFRA) (Dwingeloo, The Netherlands) * Space Research Organization Netherlands (SRON) (Utrecht, Groningen; The Netherlands) * Thüringer Landessternwarte Tautenburg (TLS) (Germany) * Kiepenheuer-Institut für Sonnenphysik (KIS) (Freiburg, Germany) * Observatoire de Paris (OBSPM) (Paris, Meudon, Nancay; France) * Observatoire de la Côte d'Azur (OCA) (Nice, France) The first observations with MIDI will now be followed up by thorough tests of the new instrument before it enters into regular service. It is planned that the first community observations will be performed at the VLTI in mid-2003. Great efforts have gone into making observations with this complex science machine as user-friendly as possible and, contrary to what is normally the case in this technically demanding branch of astronomy, scientists will find interferometric work at the VLTI quite similar to that of using the many other, more conventional VLT instruments. PR Photo 30a/02: MIDI " First Fringes " of eta Carinae. PR Photo 30b/02: The happy team at the moment of "First Fringes". PR Photo 30c/02: MIDI in the Interferometric Laboratory at Paranal. PR Video Clip 03/02: Optical path scan with "First Fringes" appearing on the computer screen. A wonderful moment ESO PR Video Clip 03/02 [384x288 pix MPEG-version] ESO PR Video Clip 03/02 (480 frames/0:19 min) [MPEG; 384x288 pix; 6.6M] [RealMedia; streaming; 56kps] [RealMedia; streaming; 200kps] Another vital step has been accomplished as planned towards full operation of the ESO Very Large Telescope (VLT) and the associated VLT Interferometer (VLTI) at the Paranal Observatory in Chile, one of the world's foremost astronomical facilities. Indeed, plans had been made more than one year ago for this milestone event to take place at the end of 2002. In the early morning of December 15, 2002, at 02:45 local time (05:45 UT), a team of astronomers and engineers from Germany, Netherlands, France and ESO celebrated the first successful combination of mid-infrared "light" beams from ANTU and MELIPAL, two of the four 8.2-m VLT Unit Telescopes . This special moment, referred to as the "First Fringes" , occurred when infrared radiation at a wavelength of 8.7 µm from the bright star eta Carinae was captured simultaneously by the two telescopes (situated 102 metres apart) and then directed via a complex optics system towards the MID-Infrared interferometric instrument (MIDI), a new, extremely sensitive and versatile instrument just installed in the underground VLT Interferometric Laboratory. Strong interferometric fringes, well visible on the computer screen to the delighted team, cf. PR Photo 30a-b/02 and PR Video Clip 03/02 , were obtained repeatedly by the MIDI instrument and the recorded data were of excellent quality. A great achievement This is the first time ever interferometry in the near-infrared 8.7 µm-band (technically: the "N"-band") with large telescopes has been accomplished and the first time at 100-m baselines. For this to happen, it was necessary to keep the difference in the length of the light paths from the two telescopes to the focus of the MIDI instrument stable and equal to within a small fraction of this wavelength during the observations, in practice to about 1 µm (0.001 mm). The team spent the first few hours of the night tuning the system, positioning the many optical components and optimizing the various feed-back mechanisms that involve precision-guided mirrors below the two telescopes and the so-called "delay lines" in the underground Interferometric Tunnel [3]. After a few attempts and successive on-line optimization, modulated "fringes" - the typical signature of interferometric measurements - became visible on the screens of the instrument computers, demonstrating conclusively the validity of the overall concept, cf. PR Video Clip 03/02 . The rest of the night was used to further trim the VLTI and MIDI. The team also observed two other objects before sunrise, the young binary star Z Canis Majoris and the enigmatic Eta Carinae - for both, interferometric fringes were convincingly obtained. The perfection of all of the 32 optical elements needed to guide the starlight towards MIDI for these observations contributed to this, as did the availability of advanced user-friendly control software, specially developed for the VLTI and its instruments in order to facilitate the future observations, also by non-specialists. Advantages of MIDI With its high sensitivity to thermal radiation, MIDI is ideally suited to study cosmic material (dust and gas) near a central hot object and heated by its radiation . In the case of astronomical observations in the visible spectral region, such material is usually hidden from view because of a strong obscuring effect that is caused by the dust it contains. Most optical observations of star-forming clouds only show the dark contours of the cloud and nothing about the complex processes that happen inside. Contrarily, this obscuring effect of the dust is often entirely insignificant at the longer mid-infrared wavelengths around 10 µm (0.01 mm) at which MIDI observes, allowing direct studies of what is going on inside. MIDI science targets Thanks to interferometry and the large collecting surface of the VLT telescopes, MIDI achieves unsurpassed image sharpness (about 0.01 arcsec) and sensitivity at these "revealing" wavelengths, promising extremely detailed views, also of faint and distant objects. Clearly, the associated opportunities for exciting research are almost unlimited. Some of the first targets for the fully operational MIDI instrument will thus include the enigmatic dust rings now believed to be located around giant black holes at the centers of quasars and strong radio galaxies. Equally interesting will be in-depth studies of those disks of matter that are known to accompany the creation of new stars and from which exoplanets are forming . And with MIDI, it will now be possible to investigate the outer zones of the extended atmospheres of giant stars where the dust grains form in the first place - those complex particles that, loaded with water ice, minerals and simple organic molecules, eventually move into interstellar space and later play a crucial role in the formation of stars and planets. MIDI - a new and powerful instrument for the VLT Interferometer The MIDI instrument has been developed by a European consortium of astronomical institutes, under the leadership of the Max-Planck-Institut für Astronomie (MPIA) in Heidelberg (Germany). Following the installation in 2001 by ESO of the VLTI test instrument, VINCI, to verify and tune the exceedingly complex optical system [3], MIDI is the first of two scientific instruments that will be devoted to interferometric observations with the VLT Interferometer during the coming decade. The other is AMBER which will combine three beams from different telescopes and will be sensitive in the wavelength region of 1-2.5 µm. The MIDI instrument weighs about 1.5 tons and is mounted on a 1.5 x 2.1 m precision optical table, placed at the centre of the underground VLT Interferometric Laboratory at the top of the Paranal mountain, cf. PR Photo 30c/02 . The large cube at the back of the table is a vacuum vessel that allows cooling of the infrared detector and the surrounding optics to temperatures of -270 to -240 °C (4K to 35K on the absolute temperature scale), which is necessary for observations at these infrared wavelengths. Despite its large dimensions, MIDI has to be very carefully adjusted to the light beams arriving from the telescopes, with initial precision exceeding 0.01° (angles) and 0.1 mm (position). The electronic equipment necessary to run the instrument is installed in a separate room in order to reduce any disturbances from heat, noise and vibrations to the lowest possible level. During the observations, the astronomers operate the entire instrument, as well as the VLT Interferometer, from a building below the mountain top, more than one hundred metres away. This state-of-the-art instrument is the outcome of a close collaboration between several European research institutes [1], greatly profiting from their combined expertise in many different technological areas. This involves the construction of large astronomical instruments for infrared observations, involving operation in vacuum and at low temperatures (MPIA in Heidelberg, Germany), designing and manufacturing optics for the extreme cryogenic environment (ASTRON in Dwingeloo, The Netherlands), designing and creating the complex software needed to run the instrument in a user-friendly way (NEVEC in Leiden, The Netherlands, and MPIA), as well as other specialised contributions from the Kiepenheuer-Institut für Sonnenphysik in Freiburg (Germany), Observatoire de Paris-Meudon and Observatoire de la Côte d'Azur in Nice (France), and Thüringer Landessternwarte in Tautenburg (Germany). This wide collaboration was carried out in close cooperation with and profiting from the professional experience of ESO that has built and now operates the Paranal Observatory, ensuring the proper interfacing between MIDI and the VLTI needed for high-performance interferometric measurements. Brief history of the MIDI project Work on the mid-infraredinterferometric instrument MIDI started in 1997 when MPIA proposed to ESO to build such a facility that would conform with ESO's plans for interferometric observations with the VLT telescopes and which would most probably become the first of its kind worldwide. Soon thereafter, the Netherlands Science Organization NOVA with ASTRON and NEVEC and the other partner institutes in France, the Netherlands and Germany joined the project. With Christoph Leinert and Uwe Graser from MPIA teaming up to lead the project, more than two dozen engineers, astronomers and students worked intensively for three and a half years on the planning, design and production, before the integration of this highly complex instrument could start at the Max-Planck-Institut für Astronomie in Heidelberg. This took place in September 2001 and was followed by a period of extensive instrumental tests. Much preparatory work had to be done at Paranal in parallel, to be ready for a smooth installation of MIDI [3]. After a positive, concluding status review of MIDI by ESO in September 2002, the many parts of the complex instrument were packed into 32 big wooden boxes, with a total weight of 8 tons, and sent from Heidelberg to Paranal by air freight. The installation of MIDI in the VLT Interferometric Laboratory began as scheduled in early November. The first test measurements were carried out during the first days of December with two 40-cm siderostats, the same that were used to obtain "first fringes" with the VINCI test instrument in March 2001, cf. ESO PR 06/01. These initial measurements led to stable, good-quality fringes on the bright stars Alpha Orionis (Betelgeuse) and Omicron Ceti (Mira). The total cost of MIDI is of the order of 6 million Euros. Of this, 1.8 million Euros are for equipment, materials and optical parts, with the remaining for salaries during the extensive planning, construction and testing of this front-line instrument. Some related technical achievements Astronomical observations of electromagnetic radiation at mid-infrared wavelengths near 10 µm are difficult, because this is the spectral region of thermal radiation from our environment . If our eyes were sensitive to that radiation, everything around us would be brilliantly bright, including the sky at night, and no stars would then be visible to the naked eye. Sensitive imaging detectors for these wavelengths have become available during the past years, but to work satisfactorily, they must be cooled to a very low temperature around -265 °C (4K - 10K) during operation. Also the optics in front of the detector must be cooled to about -240 °C - otherwise all images would be immediately overexposed, due to the added thermal radiation from those lenses and mirrors. In practice, the technical solution to this fundamental problem is a so-called closed-cycle cooler that works with high-pressure helium gas and achieves the required low temperatures on several "cold fingers" inside the instrument. However, the associated moving pistons cause vibrations which must be reduced to a minimum by means of special damping materials and connections for the cooler and the instrument. Otherwise this motion would be detrimental to the sensitive measurements, which require near-perfect mechanical stability, to within a fraction of the infrared wavelength, i.e., to 0.001 mm (1 µm) or better. Similarly, slight bending effects of the instrument parts during cool-down from room temperature would also compromise the measurements. This has been avoided by manufacturing the support of all optical parts near the detector from one single, carefully selected block of special aluminium. Still, as the light from the star being observed falls on the detector inside MIDI, it will be surrounded by strong thermal radiation from the terrestrial atmosphere in this direction and all uncooled ("warm") mirrors in the light path. The transfer of the digitally recorded images from the detector to the computer data storage must therefore occur at very high speed, one image per 0.001 sec, and always be strictly synchronized with a modulation inherent in the measurement process. This requires powerful, highly specialized and yet flexible electronics - this crucial part of the new instrument was developed over the past years at MPIA. With this and many other technical innovations successfully completed, and with the first on-the-sky observations just accomplished to the full satisfaction of the MIDI team, this new, powerful instrument will soon be ready to enter into new and unknown research territory. Hundreds of astronomers in the ESO members countries and their colleagues all over the world are now eagerly waiting to get their hands on this new facility.

The Palomar-Quest Synoptic Sky Survey

NASA Astrophysics Data System (ADS)

Mahabal, A.; Djorgovski, S. G.; Graham, M.; Williams, R.; Granett, B.; Bogosavljevic, M.; Baltay, C.; Rabinowitz, D.; Bauer, A.; Andrews, P.; Morgan, N.; Snyder, J.; Ellman, N.; Brunner, R.; Rengstorf, A. W.; Musser, J.; Gebhard, M.; Mufson, S.

2003-12-01

Exploration of the time domain is rapidly becoming one of the most exciting areas of astronomy. The Palomar-Quest synoptic sky survey has recently started producing a steady stream of data. In driftscan mode the survey covers Declination strips 4.6 deg wide, between -25 and +30 deg, at least twice in each of the two filter sets, one Johnson-Cousin's UBRI and one SDSS r'i'z'z', at a rate of about 500 square degrees per night. The scans are separated by time baselines of days to months, and we anticipate that they will extend to multi-year time scales over the next 3 to 5 years or beyond. The unprecedented amount of data makes this the largest synoptic survey of its kind both in terms of area covered and depth. We would search for both variable and transient objects, including supernovae, variable AGN, GRB orphan afterglows, cataclysmic variables, interesting stellar flares, novae, other types of variable stars, and possibly even entirely new types of objects or phenomena. We are in the process of designing a real-time data reduction pipeline which would enable a rapid discovery and spectroscopic follow-up of transients and other intersting objects. This survey can be seen as a precursor for the even larger synoptic sky surveys with LSST and PanSTARRS.

Fixation using alternative implants for the treatment of hip fractures (FAITH): design and rationale for a multi-centre randomized trial comparing sliding hip screws and cancellous screws on revision surgery rates and quality of life in the treatment of femoral neck fractures

PubMed Central

2014-01-01

Background Hip fractures are a common type of fragility fracture that afflict 293,000 Americans (over 5,000 per week) and 35,000 Canadians (over 670 per week) annually. Despite the large population impact the optimal fixation technique for low energy femoral neck fractures remains controversial. The primary objective of the FAITH study is to assess the impact of cancellous screw fixation versus sliding hip screws on rates of revision surgery at 24 months in individuals with femoral neck fractures. The secondary objective is to determine the impact on health-related quality of life, functional outcomes, health state utilities, fracture healing, mortality and fracture-related adverse events. Methods/Design FAITH is a multi-centre, multi-national randomized controlled trial utilizing minimization to determine patient allocation. Surgeons in North America, Europe, Australia, and Asia will recruit a total of at least 1,000 patients with low-energy femoral neck fractures. Using central randomization, patients will be allocated to receive surgical treatment with cancellous screws or a sliding hip screw. Patient outcomes will be assessed at one week (baseline), 10 weeks, 6, 12, 18, and 24 months post initial fixation. We will independently adjudicate revision surgery and complications within 24 months of the initial fixation. Outcome analysis will be performed using a Cox proportional hazards model and likelihood ratio test. Discussion This study represents major international efforts to definitively resolve the treatment of low-energy femoral neck fractures. This trial will not only change current Orthopaedic practice, but will also set a benchmark for the conduct of future Orthopaedic trials. Trial registration The FAITH trial is registered at ClinicalTrials.gov (Identifier NCT00761813). PMID:24965132

An overview of instrumentation for the Large Binocular Telescope

NASA Astrophysics Data System (ADS)

Wagner, R. Mark

2012-09-01

An overview of instrumentation for the Large Binocular Telescope (LBT) is presented. Optical instrumentation includes the Large Binocular Camera (LBC), a pair of wide-field (27' x 27') mosaic CCD imagers at the prime focus, and the Multi-Object Double Spectrograph (MODS), a pair of dual-beam blue-red optimized long-slit spectrographs mounted at the left and right direct F/15 Gregorian foci incorporating multiple slit masks for multi-object spectroscopy over a 6' field and spectral resolutions of up to 2000. Infrared instrumentation includes the LBT Near-IR Spectroscopic Utility with Camera and Integral Field Unit for Extragalactic Research (LUCI), a modular near-infrared (0.9-2.5 μm) imager and spectrograph pair mounted at the left and right front bent F/15 Gregorian foci and designed for seeing-limited (FOV: 4' × 4') imaging, long-slit spectroscopy, and multiobject spectroscopy utilizing cooled slit masks and diffraction limited (FOV: 0'.5 × 0'.5) imaging and long-slit spectroscopy. Strategic instruments under development that can utilize the full 23-m baseline of the LBT include an interferometric cryogenic beam combiner with near-infrared and thermal-infrared instruments for Fizeau imaging and nulling interferometry (LBTI) and an optical bench near-infrared beam combiner utilizing multi-conjugate adaptive optics for high angular resolution and sensitivity (LINC-NIRVANA). LBTI is currently undergoing commissioning on the LBT and utilizing the installed adaptive secondary mirrors in both single- sided and two-sided beam combination modes. In addition, a fiber-fed bench spectrograph (PEPSI) capable of ultra high resolution spectroscopy and spectropolarimetry (R = 40,000-300,000) will be available as a principal investigator instrument. Over the past four years the LBC pair, LUCI1, and MODS1 have been commissioned and are now scheduled for routine partner science observations. The delivery of both LUCI2 and MODS2 is anticipated before the end of 2012. The availability of all these instruments mounted simultaneously on the LBT permits unique science, flexible scheduling, and improved operational support.

Long-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE): Conceptual Design Report. Volume 1: The LBNF and DUNE Projects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Acciarri, R.

2016-01-22

This document presents the Conceptual Design Report (CDR) put forward by an international neutrino community to pursue the Deep Underground Neutrino Experiment at the Long-Baseline Neutrino Facility (LBNF/DUNE), a groundbreaking science experiment for long-baseline neutrino oscillation studies and for neutrino astrophysics and nucleon decay searches. The DUNE far detector will be a very large modular liquid argon time-projection chamber (LArTPC) located deep underground, coupled to the LBNF multi-megawatt wide-band neutrino beam. DUNE will also have a high-resolution and high-precision near detector.

Processing Technology Selection for Municipal Sewage Treatment Based on a Multi-Objective Decision Model under Uncertainty.

PubMed

Chen, Xudong; Xu, Zhongwen; Yao, Liming; Ma, Ning

2018-03-05

This study considers the two factors of environmental protection and economic benefits to address municipal sewage treatment. Based on considerations regarding the sewage treatment plant construction site, processing technology, capital investment, operation costs, water pollutant emissions, water quality and other indicators, we establish a general multi-objective decision model for optimizing municipal sewage treatment plant construction. Using the construction of a sewage treatment plant in a suburb of Chengdu as an example, this paper tests the general model of multi-objective decision-making for the sewage treatment plant construction by implementing a genetic algorithm. The results show the applicability and effectiveness of the multi-objective decision model for the sewage treatment plant. This paper provides decision and technical support for the optimization of municipal sewage treatment.

Multi-Objective Programming for Lot-Sizing with Quantity Discount

NASA Astrophysics Data System (ADS)

Kang, He-Yau; Lee, Amy H. I.; Lai, Chun-Mei; Kang, Mei-Sung

2011-11-01

Multi-objective programming (MOP) is one of the popular methods for decision making in a complex environment. In a MOP, decision makers try to optimize two or more objectives simultaneously under various constraints. A complete optimal solution seldom exists, and a Pareto-optimal solution is usually used. Some methods, such as the weighting method which assigns priorities to the objectives and sets aspiration levels for the objectives, are used to derive a compromise solution. The ɛ-constraint method is a modified weight method. One of the objective functions is optimized while the other objective functions are treated as constraints and are incorporated in the constraint part of the model. This research considers a stochastic lot-sizing problem with multi-suppliers and quantity discounts. The model is transformed into a mixed integer programming (MIP) model next based on the ɛ-constraint method. An illustrative example is used to illustrate the practicality of the proposed model. The results demonstrate that the model is an effective and accurate tool for determining the replenishment of a manufacturer from multiple suppliers for multi-periods.

Application of dragonfly algorithm for optimal performance analysis of process parameters in turn-mill operations- A case study

NASA Astrophysics Data System (ADS)

Vikram, K. Arun; Ratnam, Ch; Lakshmi, VVK; Kumar, A. Sunny; Ramakanth, RT

2018-02-01

Meta-heuristic multi-response optimization methods are widely in use to solve multi-objective problems to obtain Pareto optimal solutions during optimization. This work focuses on optimal multi-response evaluation of process parameters in generating responses like surface roughness (Ra), surface hardness (H) and tool vibration displacement amplitude (Vib) while performing operations like tangential and orthogonal turn-mill processes on A-axis Computer Numerical Control vertical milling center. Process parameters like tool speed, feed rate and depth of cut are considered as process parameters machined over brass material under dry condition with high speed steel end milling cutters using Taguchi design of experiments (DOE). Meta-heuristic like Dragonfly algorithm is used to optimize the multi-objectives like ‘Ra’, ‘H’ and ‘Vib’ to identify the optimal multi-response process parameters combination. Later, the results thus obtained from multi-objective dragonfly algorithm (MODA) are compared with another multi-response optimization technique Viz. Grey relational analysis (GRA).

Predicting plant protein subcellular multi-localization by Chou's PseAAC formulation based multi-label homolog knowledge transfer learning.

PubMed

Mei, Suyu

2012-10-07

Recent years have witnessed much progress in computational modeling for protein subcellular localization. However, there are far few computational models for predicting plant protein subcellular multi-localization. In this paper, we propose a multi-label multi-kernel transfer learning model for predicting multiple subcellular locations of plant proteins (MLMK-TLM). The method proposes a multi-label confusion matrix and adapts one-against-all multi-class probabilistic outputs to multi-label learning scenario, based on which we further extend our published work MK-TLM (multi-kernel transfer learning based on Chou's PseAAC formulation for protein submitochondria localization) for plant protein subcellular multi-localization. By proper homolog knowledge transfer, MLMK-TLM is applicable to novel plant protein subcellular localization in multi-label learning scenario. The experiments on plant protein benchmark dataset show that MLMK-TLM outperforms the baseline model. Unlike the existing models, MLMK-TLM also reports its misleading tendency, which is important for comprehensive survey of model's multi-labeling performance. Copyright © 2012 Elsevier Ltd. All rights reserved.

77 FR 72412 - International Mail Contract

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-05

... Inbound Competitive Multi-Service Agreements with Foreign Operators 1 product and identifies the TNT... of the TNT Agreement as the baseline agreement was confirmed in Order No. 840, issued September 7...

Statistical Mechanics of Node-perturbation Learning with Noisy Baseline

NASA Astrophysics Data System (ADS)

Hara, Kazuyuki; Katahira, Kentaro; Okada, Masato

2017-02-01

Node-perturbation learning is a type of statistical gradient descent algorithm that can be applied to problems where the objective function is not explicitly formulated, including reinforcement learning. It estimates the gradient of an objective function by using the change in the object function in response to the perturbation. The value of the objective function for an unperturbed output is called a baseline. Cho et al. proposed node-perturbation learning with a noisy baseline. In this paper, we report on building the statistical mechanics of Cho's model and on deriving coupled differential equations of order parameters that depict learning dynamics. We also show how to derive the generalization error by solving the differential equations of order parameters. On the basis of the results, we show that Cho's results are also apply in general cases and show some general performances of Cho's model.

Toward automated face detection in thermal and polarimetric thermal imagery

NASA Astrophysics Data System (ADS)

Gordon, Christopher; Acosta, Mark; Short, Nathan; Hu, Shuowen; Chan, Alex L.

2016-05-01

Visible spectrum face detection algorithms perform pretty reliably under controlled lighting conditions. However, variations in illumination and application of cosmetics can distort the features used by common face detectors, thereby degrade their detection performance. Thermal and polarimetric thermal facial imaging are relatively invariant to illumination and robust to the application of makeup, due to their measurement of emitted radiation instead of reflected light signals. The objective of this work is to evaluate a government off-the-shelf wavelet based naïve-Bayes face detection algorithm and a commercial off-the-shelf Viola-Jones cascade face detection algorithm on face imagery acquired in different spectral bands. New classifiers were trained using the Viola-Jones cascade object detection framework with preprocessed facial imagery. Preprocessing using Difference of Gaussians (DoG) filtering reduces the modality gap between facial signatures across the different spectral bands, thus enabling more correlated histogram of oriented gradients (HOG) features to be extracted from the preprocessed thermal and visible face images. Since the availability of training data is much more limited in the thermal spectrum than in the visible spectrum, it is not feasible to train a robust multi-modal face detector using thermal imagery alone. A large training dataset was constituted with DoG filtered visible and thermal imagery, which was subsequently used to generate a custom trained Viola-Jones detector. A 40% increase in face detection rate was achieved on a testing dataset, as compared to the performance of a pre-trained/baseline face detector. Insights gained in this research are valuable in the development of more robust multi-modal face detectors.

Long-term lightcurves from combined unified very high energy γ-ray data

NASA Astrophysics Data System (ADS)

Tluczykont, M.; Bernardini, E.; Satalecka, K.; Clavero, R.; Shayduk, M.; Kalekin, O.

2010-12-01

Context. Very high-energy (VHE, E > 100 GeV) γ-ray data are a valuable input for multi-wavelength and multi-messenger (e.g. combination with neutrino data) studies. Aims: We aim at the conservation and homogenization of historical, current, and future VHE γ-ray-data on active galactic nuclei (AGN). Methods: We have collected lightcurve data taken by major VHE experiments since 1991 and combined them into long-term lightcurves for several AGN, and now provide our collected datasets for further use. Due to the lack of common data formats in VHE γ-ray astronomy, we have defined relevant datafields to be stored in standard data formats. The time variability of the combined VHE lightcurve data was investigated, and correlation with archival X-ray data collected by RXTE/ASM tested. Results: The combination of data on the prominent blazar Mrk 421 from different experiments yields a lightcurve spanning more than a decade. From this combined dataset we derive an integral baseline flux from Mrk 421 that must be lower than 33% of the Crab Nebula flux above 1 TeV. The analysis of the time variability yields log-normal flux variations in the VHE-data on Mrk 421. Conclusions: Existing VHE data contain valuable information concerning the variability of AGN and can be an important ingredient for multi-wavelength or multi-messenger studies. In the future, upcoming and planned experiments will provide more data from many transient objects, and the interaction of VHE astronomy with classical astronomy will intensify. In this context a unified and exchangeable data format will become increasingly important. Our data collection is available at the url: http://nuastro-zeuthen.desy.de/magic_experiment/projects/light_curve_archive/index_eng.html

Two-year clinical trial of a universal adhesive in total-etch and self-etch mode in non-carious cervical lesions☆

PubMed Central

Lawson, Nathaniel C.; Robles, Augusto; Fu, Chin-Chuan; Lin, Chee Paul; Sawlani, Kanchan; Burgess, John O.

2016-01-01

Objectives To compare the clinical performance of Scotchbond™ Universal Adhesive used in self- and total-etch modes and two-bottle Scotchbond™ Multi-purpose Adhesive in total-etch mode for Class 5 non-carious cervical lesions (NCCLs). Methods 37 adults were recruited with 3 or 6 NCCLs (>1.5 mm deep). Teeth were isolated, and a short cervical bevel was prepared. Teeth were restored randomly with Scotchbond Universal total-etch, Scotchbond Universal self-etch or Scotchbond Multi-purpose followed with a composite resin. Restorations were evaluated at baseline, 6, 12 and 24 months for marginal adaptation, marginal discoloration, secondary caries, and sensitivity to cold using modified USPHS Criteria. Patients and evaluators were blinded. Logistic and linear regression models using a generalized estimating equation were applied to evaluate the effects of time and adhesive material on clinical assessment outcomes over the 24 month follow-up period. Kaplan–Meier method was used to compare the retention between adhesive materials. Results Clinical performance of all adhesive materials deteriorated over time for marginal adaptation, and discoloration (p <0.0001). Both Scotchbond Universal self-etch and Scotchbond Multi-purpose materials were more than three times as likely to contribute to less satisfying performance in marginal discoloration over time than Scotchbond Universal total-etch. The retention rates up to 24 months were 87.6%, 94.9% and 100% for Scotchbond Multi-purpose and Scotchbond Universal self-etch and total-etch, respectively. Conclusions Scotchbond Universal in self- and total- etch modes performed similar to or better than Scotchbond Multipurpose, respectively. Clinical significance 24 month evaluation of a universal adhesive indicates acceptable clinical performance, particularly in a total-etch mode. PMID:26231300

Early menopause predicts future coronary heart disease and stroke: the Multi-Ethnic Study of Atherosclerosis.

PubMed

Wellons, Melissa; Ouyang, Pamela; Schreiner, Pamela J; Herrington, David M; Vaidya, Dhananjay

2012-10-01

Cardiovascular disease is the number one killer of women. Identifying women at risk of cardiovascular disease has tremendous public health importance. Early menopause is associated with increased cardiovascular disease events in some predominantly white populations, but not consistently. Our objective was to determine if self-reported early menopause (menopause at an age <46 y) identifies women as at risk for future coronary heart disease or stroke. The study population came from the Multi-Ethnic Study of Atherosclerosis, a longitudinal, ethnically diverse cohort study of US men and women aged 45 to 84 years enrolled in 2000-2002 and followed up until 2008. The association between a personal history of early menopause (either natural menopause or surgical removal of ovaries at an age <46 y) and future coronary heart disease and stroke was assessed in 2,509 women (ages 45-84 y; 987 white, 331 Chinese, 641 black, and 550 Hispanic) from the Multi-ethnic Study Atherosclerosis who were free of cardiovascular disease at baseline. Of 2,509 women, 693 (28%) reported either surgical or natural early menopause. In survival curves, women with early menopause had worse coronary heart disease and stroke-free survival (log rank P = 0.008 and P = 0.0158). In models adjusted for age, race/ethnicity, Multi-ethnic Study Atherosclerosis site, and traditional cardiovascular disease risk factors, this risk for coronary heart disease and stroke remained (hazard ratio, 2.08; 95% CI, 1.17-3.70; and hazard ratio, 2.19; 95% CI, 1.11-4.32, respectively). Early menopause is positively associated with coronary heart disease and stroke in a multiethnic cohort, independent of traditional cardiovascular disease risk factors.

Association between objective and subjective binge eating and psychopathology during a psychological treatment trial for bulimic symptoms.

PubMed

Goldschmidt, Andrea B; Accurso, Erin C; Crosby, Ross D; Cao, Li; Ellison, Jo; Smith, Tracey L; Klein, Marjorie H; Mitchell, James E; Crow, Scott J; Wonderlich, Stephen A; Peterson, Carol B

2016-12-01

Although loss of control (LOC) while eating is a core construct of bulimia nervosa (BN), questions remain regarding its validity and prognostic significance independent of overeating. We examined trajectories of objective and subjective binge eating (OBE and SBE, respectively; i.e., LOC eating episodes involving an objectively or subjectively large amount of food) among adults participating in psychological treatments for BN-spectrum disorders (n = 80). We also explored whether changes in the frequency of these eating episodes differentially predicted changes in eating-related and general psychopathology and, conversely, whether changes in eating-related and general psychopathology predicted differential changes in the frequency of these eating episodes. Linear mixed models with repeated measures revealed that OBE decreased twice as rapidly as SBE throughout treatment and 4-month follow-up. Generalized linear models revealed that baseline to end-of-treatment reductions in SBE frequency predicted baseline to 4-month follow-up changes in eating-related psychopathology, depression, and anxiety, while changes in OBE frequency were not predictive of psychopathology at 4-month follow-up. Zero-inflation models indicated that baseline to end-of-treatment changes in eating-related psychopathology and depression symptoms predicted baseline to 4-month follow-up changes in OBE frequency, while changes in anxiety and self-esteem did not. Baseline to end-of-treatment changes in eating-related psychopathology, self-esteem, and anxiety predicted baseline to 4-month follow-up changes in SBE frequency, while baseline to end-of-treatment changes in depression did not. Based on these findings, LOC accompanied by objective overeating may reflect distress at having consumed an objectively large amount of food, whereas LOC accompanied by subjective overeating may reflect more generalized distress related to one's eating- and mood-related psychopathology. BN treatments should comprehensively target LOC eating and related psychopathology, particularly in the context of subjectively large episodes, to improve global outcomes. Copyright © 2016. Published by Elsevier Ltd.

Low-thrust orbit transfer optimization with refined Q-law and multi-objective genetic algorithm

NASA Technical Reports Server (NTRS)

Lee, Seungwon; Petropoulos, Anastassios E.; von Allmen, Paul

2005-01-01

An optimization method for low-thrust orbit transfers around a central body is developed using the Q-law and a multi-objective genetic algorithm. in the hybrid method, the Q-law generates candidate orbit transfers, and the multi-objective genetic algorithm optimizes the Q-law control parameters in order to simultaneously minimize both the consumed propellant mass and flight time of the orbit tranfer. This paper addresses the problem of finding optimal orbit transfers for low-thrust spacecraft.

Implications of Preference and Problem Formulation on the Operating Policies of Complex Multi-Reservoir Systems

NASA Astrophysics Data System (ADS)

Quinn, J.; Reed, P. M.; Giuliani, M.; Castelletti, A.

2016-12-01

Optimizing the operations of multi-reservoir systems poses several challenges: 1) the high dimension of the problem's states and controls, 2) the need to balance conflicting multi-sector objectives, and 3) understanding how uncertainties impact system performance. These difficulties motivated the development of the Evolutionary Multi-Objective Direct Policy Search (EMODPS) framework, in which multi-reservoir operating policies are parameterized in a given family of functions and then optimized for multiple objectives through simulation over a set of stochastic inputs. However, properly framing these objectives remains a severe challenge and a neglected source of uncertainty. Here, we use EMODPS to optimize operating policies for a 4-reservoir system in the Red River Basin in Vietnam, exploring the consequences of optimizing to different sets of objectives related to 1) hydropower production, 2) meeting multi-sector water demands, and 3) providing flood protection to the capital city of Hanoi. We show how coordinated operation of the reservoirs can differ markedly depending on how decision makers weigh these concerns. Moreover, we illustrate how formulation choices that emphasize the mean, tail, or variability of performance across objective combinations must be evaluated carefully. Our results show that these choices can significantly improve attainable system performance, or yield severe unintended consequences. Finally, we show that satisfactory validation of the operating policies on a set of out-of-sample stochastic inputs depends as much or more on the formulation of the objectives as on effective optimization of the policies. These observations highlight the importance of carefully considering how we abstract stakeholders' objectives and of iteratively optimizing and visualizing multiple problem formulation hypotheses to ensure that we capture the most important tradeoffs that emerge from different stakeholder preferences.

Performance of Variable Capacity Heat Pumps in a Mixed Humid Climate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Munk, Jeffrey D; Gehl, Anthony C; Jackson, Roderick K

2012-04-01

Variable capacity heat pumps represent the next wave of technology for heat pumps. In this report, the performance of two variable capacity heat pumps (HPs) is compared to that of a single or two stage baseline system. The units were installed in two existing research houses located in Knoxville, TN. These houses were instrumented to collect energy use and temperature data while both the baseline systems and variable capacity systems were installed. The homes had computer controlled simulated occupancy, which provided consistent schedules for hot water use and lighting. The temperature control and energy use of the systems were comparedmore » during both the heating and cooling seasons. Multiple linear regression models were used along with TMY3 data for Knoxville, TN in order to normalize the effect that the outdoor air temperature has on energy use. This enables a prediction of each system's energy use over a year with the same weather. The first system was a multi-split system consisting of 8 indoor units and a single outdoor unit. This system replaced a 16 SEER single stage HP with a zoning system, which served as the baseline. Data was collected on the baseline system from August 2009 to December 2010 and on the multi-split system from January 2011 to January 2012. Soon after the installation of the multi-split system, some of the smaller rooms began over-conditioning. This was determined to be caused by a small amount of continuous refrigerant flow to all of the indoor units when the outdoor unit was running regardless of whether they were calling for heat. This, coupled with the fact that the indoor fans run continuously, was providing enough heat in some rooms to exceed the set point. In order to address this, the indoor fans were disabled when not actively heating per the manufacturer's recommendation. Based on the measured data, the multi-split system was predicted to use 40% more energy in the heating season and 16% more energy in the cooling season than the baseline system, for the typical meteorological year weather data. The AHRI ratings indicated that the baseline system would perform slightly better than the multi-split system, but not by as large of a margin as seen in this study. The multi-split system was able to maintain more consistent temperature throughout the house than the baseline system, but it did allow relative humidity levels to increase above 60% in the summer. The second system was a split system with an inverter driven compressor and a single ducted air handler. This unit replaced a 16 SEER two stage HP with a zoning system. Data was collected on the baseline system from July 2009 to November 2010 and on the ducted inverter system from December 2010 to January 2012. The ducted inverter system did not offer a zone controller, so it functioned as a single zone system. Due to this fact, the registers had to be manually adjusted in order to better maintain consistent temperatures between the two levels of the house. The predicted heating season energy use for the ducted inverter system, based on the measured energy use, was 30% less than that of the baseline system for the typical meteorological year. However, the baseline system was unable to operate in its high stage due to a wiring issue with the zone controller. This resulted in additional resistance heat use during the winter and therefore higher energy use than would be expected in a properly performing unit. The AHRI ratings would indicate that the baseline system would use less energy than the ducted inverter system, which is opposite to the results of this study. During the cooling season, the ducted inverter system was predicted to use 23% more energy than the baseline system during the typical meteorological year. This is also opposite of the results expected by comparing the AHRI ratings. After a detailed comparison of the ducted inverter system's power use compared to that of a recently installed identical system at a retro-fit study house, there is concern that the unit is not operating as intended. The power use and cycles indicate that the unit is performing more like a single stage unit than a variable capacity unit. Analysis of the data indicates that a change in operating behavior occurred during a service call shortly after the installation of the unit. The logbook only indicates that refrigerant charge was added, but does not indicate any other change. This is being investigated further. While the energy comparison results of these two variable capacity heat pumps is generally underwhelming, it is difficult to draw any hard conclusions about the maximum attainable efficiency of these units when optimally installed. Both units appear to have undesirable conditions associated with the installation or operation, which could have had an adverse effect on their energy use.« less

Multi-criteria decision models for forestry and natural resources management: an annotated bibliography

Treesearch

Joseph E. de Steiguer; Leslie Liberti; Albert Schuler; Bruce Hansen

2003-01-01

Foresters and natural resource managers must balance conflicting objectives when developing land-management plans. Conflicts may encompass economic, environmental, social, cultural, technical, and aesthetic objectives. Selecting the best combination of management uses from numerous objectives is difficult and challenging. Multi-Criteria Decision Models (MCDM) provide a...

An overview and the current status of instrumentation at the Large Binocular Telescope Observatory

NASA Astrophysics Data System (ADS)

Wagner, R. Mark; Edwards, Michelle L.; Kuhn, Olga; Thompson, David; Veillet, Christian

2014-07-01

An overview of instrumentation for the Large Binocular Telescope (LBT) is presented. Optical instrumentation includes the Large Binocular Camera (LBC), a pair of wide-field (24' × 24') mosaic CCD imagers at the prime focus, and the Multi-Object Double Spectrograph (MODS), a pair of dual-beam blue-red optimized long-slit spectrographs mounted at the left and right direct F/15 Gregorian foci incorporating multiple slit masks for multi-object spectroscopy over a 6' field and spectral resolutions of up to 2000. Infrared instrumentation includes the LBT Near-IR Spectrometer (LUCI), a modular near-infrared (0.9-2.5 μm) imager and spectrograph pair mounted at the left and right front-bent F/15 Gregorian foci and designed for seeing-limited (FOV: 4' × 4') imaging, long-slit spectroscopy, and multi-object spectroscopy utilizing cooled slit masks and diffraction limited (FOV: 0'.5 x 0'.5) imaging and long-slit spectroscopy. Strategic instruments under development that can utilize the full 23 m baseline of the LBT include an interferometric cryogenic beam combiner with near-infrared and thermal-infrared instruments for Fizeau imaging and nulling interferometry (LBTI) and an optical bench near- infrared beam combiner utilizing multi-conjugate adaptive optics for high angular resolution and sensitivity (LINC-NIRVANA). LBTI is currently undergoing commissioning and performing science observations on the LBT utilizing the installed adaptive secondary mirrors in both single-sided and two-sided beam combination modes. In addition, a fiber-fed bench spectrograph (PEPSI) capable of ultra high resolution spectroscopy and spectropolarimetry (R = 40,000-300,000) will be available as a principal investigator instrument. Installation and testing of the bench spectrograph will begin in July 2014. Over the past four years the LBC pair, LUCI1, and MODS1 have been commissioned and are now scheduled for routine partner science observations. Both LUCI2 and MODS2 passed their laboratory acceptance milestones in the summer of 2013 and have been installed on the LBT. LUCI2 is currently being commissioned and the data analysis is well underway. Diffraction-limited commissioning of its adaptive optics modes will begin in the 2014B semester. MODS2 commissioning began in May 2014 and will completed in the 2014B semester as well. Binocular testing and commissioning of both the LUCI and MODS pairs will begin in 2014B with the goal that this capability could be offered sometime in 2015. The availability of all these instruments mounted simultaneously on the LBT permits unique science, flexible scheduling, and improved operational support.

Testing Maternal Depression and Attachment Style as Moderators of Early Head Start's Effects on Parenting

PubMed Central

Berlin, Lisa J.; Whiteside-Mansell, Leanne; Roggman, Lori A.; Green, Beth L.; Robinson, JoAnn; Spieker, Susan

2010-01-01

This study examined maternal depression, attachment avoidance, and attachment anxiety as moderators of Early Head Start's effects on four parenting outcomes assessed at age 3. Participants (N = 947) were drawn from six sites of the Early Head Start National Research and Evaluation Project, a multi-site randomized trial. Findings suggest more positive program effects for mothers with less initial attachment avoidance or attachment anxiety. First, baseline attachment avoidance moderated EHS program effects on observed maternal supportiveness, such that program mothers with lower baseline attachment avoidance were rated as more supportive of their 3-year-olds than program mothers with higher baseline attachment avoidance. Second, program effects on spanking varied depending on mothers’ baseline attachment anxiety. PMID:21240694

Testing maternal depression and attachment style as moderators of Early Head Start's effects on parenting.

PubMed

Berlin, Lisa J; Whiteside-Mansell, Leanne; Roggman, Lori A; Green, Beth L; Robinson, JoAnn; Spieker, Susan

2011-01-01

This study examined maternal depression, attachment avoidance, and attachment anxiety as moderators of Early Head Start's effects on four parenting outcomes assessed at age three. Participants (N = 947) were drawn from six sites of the Early Head Start National Research and Evaluation Project, a multi-site randomized trial. Findings suggest more positive program effects for mothers with less initial attachment avoidance or attachment anxiety. First, baseline attachment avoidance moderated Early Head Start program effects on observed maternal supportiveness, such that program mothers with lower baseline attachment avoidance were rated as more supportive of their three-year-olds than program mothers with higher baseline attachment avoidance. Second, program effects on spanking varied depending on mothers' baseline attachment anxiety.

Unraveling the Mystery of Exozodiacal Dust

NASA Astrophysics Data System (ADS)

Ertel, S.; Augereau, J.-C.; Thébault, P.; Absil, O.; Bonsor, A.; Defrère, D.; Kral, Q.; Le Bouquin, J.-B.; Lebreton, J.; Coudé du Foresto, V.

2014-01-01

Exozodiacal dust clouds are thought to be the extrasolar analogs of the Solar System's zodiacal dust. Studying these systems provides insights in the architecture of the innermost regions of planetary systems, including the Habitable Zone. Furthermore, the mere presence of the dust may result in major obstacles for direct imaging of earth-like planets. Our EXOZODI project aims to detect and study exozodiacal dust and to explain its origin. We are carrying out the first large, near-infrared interferometric survey in the northern (CHARA/FLUOR) and southern (VLTI/PIONIER) hemispheres. Preliminary results suggest a detection rate of up to 30% around A to K type stars and interesting trends with spectral type and age. We focus here on presenting the observational work carried out by our team.

Use of Multi-Modal Media and Tools in an Online Information Literacy Course: College Students' Attitudes and Perceptions

ERIC Educational Resources Information Center

Chen, Hsin-Liang; Williams, James Patrick

2009-01-01

This project studies the use of multi-modal media objects in an online information literacy class. One hundred sixty-two undergraduate students answered seven surveys. Significant relationships are found among computer skills, teaching materials, communication tools and learning experience. Multi-modal media objects and communication tools are…

Novel multi-telescopes beam combiners for next generation instruments (FIRST/SUBARU)

NASA Astrophysics Data System (ADS)

Martin, G.; Pugnat, T.; Gardillou, F.; Cassagnettes, C.; Barbier, D.; Guyot, C.; Hauden, J.; Huby, E.; Lacour, S.

2016-07-01

Integrated optic devices are nowadays achieving extremely good performances in the field of astronomical interferometry, as shown by PIONIER or GRAVITY silica/silicon-based instruments, already installed at VLTI. In order to address other wavelengths, increase the number of apertures to be combined and eventually ensure on-chip phase modulation, we are working on a novel generation of beam combiners, based on the hybridization of glass waveguides, that can ensure very sharp bend radius, high confinement and low propagation losses, together with lithium niobate phase modulators and channel waveguides that can achieve on-chip, fast (<100kHz) phase modulation. The work presented here has been realized in collaboration with our technological partners TeemPhotonics for glass waveguides and iXBlue-PSD for lithium niobate phase modulators. We will present our results on a hybrid glass/niobate (passive/active) beam combiner that has been developed in the context of FIRST/SUBARU 9T beam combiner. The combiner is structured in three parts: a) the first stage (passive glass) achieves beam splitting from one input to eight outputs, and that for nine input fibers coming from the sub-apertures of the Subaru telescope; b) the second stage consists on a 72 channel waveguides lithium niobate phase modulator in a push-pull configuration that allows to modify on-chip the relative phase between the 36 pairs of waveguides; c) a final recombination system of Y-junctions (passive glass) that allows to obtain combination of each input to every other one. The aim of this presentation is to discuss different issues of the combiners, such as transmission, birefringence, half-wave voltage modulation and spectral range.

Fuzzy multi objective transportation problem – evolutionary algorithm approach

NASA Astrophysics Data System (ADS)

Karthy, T.; Ganesan, K.

2018-04-01

This paper deals with fuzzy multi objective transportation problem. An fuzzy optimal compromise solution is obtained by using Fuzzy Genetic Algorithm. A numerical example is provided to illustrate the methodology.

Parameter Estimation of Computationally Expensive Watershed Models Through Efficient Multi-objective Optimization and Interactive Decision Analytics

NASA Astrophysics Data System (ADS)

Akhtar, Taimoor; Shoemaker, Christine

2016-04-01

Watershed model calibration is inherently a multi-criteria problem. Conflicting trade-offs exist between different quantifiable calibration criterions indicating the non-existence of a single optimal parameterization. Hence, many experts prefer a manual approach to calibration where the inherent multi-objective nature of the calibration problem is addressed through an interactive, subjective, time-intensive and complex decision making process. Multi-objective optimization can be used to efficiently identify multiple plausible calibration alternatives and assist calibration experts during the parameter estimation process. However, there are key challenges to the use of multi objective optimization in the parameter estimation process which include: 1) multi-objective optimization usually requires many model simulations, which is difficult for complex simulation models that are computationally expensive; and 2) selection of one from numerous calibration alternatives provided by multi-objective optimization is non-trivial. This study proposes a "Hybrid Automatic Manual Strategy" (HAMS) for watershed model calibration to specifically address the above-mentioned challenges. HAMS employs a 3-stage framework for parameter estimation. Stage 1 incorporates the use of an efficient surrogate multi-objective algorithm, GOMORS, for identification of numerous calibration alternatives within a limited simulation evaluation budget. The novelty of HAMS is embedded in Stages 2 and 3 where an interactive visual and metric based analytics framework is available as a decision support tool to choose a single calibration from the numerous alternatives identified in Stage 1. Stage 2 of HAMS provides a goodness-of-fit measure / metric based interactive framework for identification of a small subset (typically less than 10) of meaningful and diverse set of calibration alternatives from the numerous alternatives obtained in Stage 1. Stage 3 incorporates the use of an interactive visual analytics framework for decision support in selection of one parameter combination from the alternatives identified in Stage 2. HAMS is applied for calibration of flow parameters of a SWAT model, (Soil and Water Assessment Tool) designed to simulate flow in the Cannonsville watershed in upstate New York. Results from the application of HAMS to Cannonsville indicate that efficient multi-objective optimization and interactive visual and metric based analytics can bridge the gap between the effective use of both automatic and manual strategies for parameter estimation of computationally expensive watershed models.

Multi-class geospatial object detection based on a position-sensitive balancing framework for high spatial resolution remote sensing imagery

NASA Astrophysics Data System (ADS)

Zhong, Yanfei; Han, Xiaobing; Zhang, Liangpei

2018-04-01

Multi-class geospatial object detection from high spatial resolution (HSR) remote sensing imagery is attracting increasing attention in a wide range of object-related civil and engineering applications. However, the distribution of objects in HSR remote sensing imagery is location-variable and complicated, and how to accurately detect the objects in HSR remote sensing imagery is a critical problem. Due to the powerful feature extraction and representation capability of deep learning, the deep learning based region proposal generation and object detection integrated framework has greatly promoted the performance of multi-class geospatial object detection for HSR remote sensing imagery. However, due to the translation caused by the convolution operation in the convolutional neural network (CNN), although the performance of the classification stage is seldom influenced, the localization accuracies of the predicted bounding boxes in the detection stage are easily influenced. The dilemma between translation-invariance in the classification stage and translation-variance in the object detection stage has not been addressed for HSR remote sensing imagery, and causes position accuracy problems for multi-class geospatial object detection with region proposal generation and object detection. In order to further improve the performance of the region proposal generation and object detection integrated framework for HSR remote sensing imagery object detection, a position-sensitive balancing (PSB) framework is proposed in this paper for multi-class geospatial object detection from HSR remote sensing imagery. The proposed PSB framework takes full advantage of the fully convolutional network (FCN), on the basis of a residual network, and adopts the PSB framework to solve the dilemma between translation-invariance in the classification stage and translation-variance in the object detection stage. In addition, a pre-training mechanism is utilized to accelerate the training procedure and increase the robustness of the proposed algorithm. The proposed algorithm is validated with a publicly available 10-class object detection dataset.

Motivational Interviewing or Reminders for Glaucoma Medication Adherence? Results of a Multi-Site Randomized Controlled Trial

PubMed Central

Schmiege, Sarah J.; Mansberger, Steven L.; Sheppler, Christina; Kammer, Jeffrey; Fitzgerald, Timothy; Kahook, Malik Y.

2017-01-01

Objective Nonadherence reduces glaucoma treatment efficacy. Motivational interviewing (MI) is a well-studied adherence intervention, but has not been tested in glaucoma. Reminder interventions also may improve adherence. Design 201 patients with glaucoma or ocular hypertension were urn-randomized to receive MI delivered by an ophthalmic technician (OT), usual care, or a minimal behavioral intervention (reminder calls). Main Outcome Measures Outcomes included electronic monitoring with Medication Event Monitoring System (MEMS) bottles, two self-report adherence measures, patient satisfaction, and clinical outcomes. Multilevel modeling was used to test differences in MEMS results by group over time; ANCOVA was used to compare groups on other measures. Results Reminder calls increased adherence compared to usual care based on MEMS, p = .005, and self-report, p = .04. MI had a nonsignificant effect but produced higher satisfaction than reminder calls, p = .007. Treatment fidelity was high on most measures, with observable differences in behavior between groups. All groups had high baseline adherence that limited opportunities for change. Conclusion Reminder calls, but not MI, led to better adherence than usual care. Although a large literature supports MI, reminder calls might be a cost-effective intervention for patients with high baseline adherence. Replication is needed with less adherent participants. PMID:27701902

Primal-dual convex optimization in large deformation diffeomorphic metric mapping: LDDMM meets robust regularizers

NASA Astrophysics Data System (ADS)

Hernandez, Monica

2017-12-01

This paper proposes a method for primal-dual convex optimization in variational large deformation diffeomorphic metric mapping problems formulated with robust regularizers and robust image similarity metrics. The method is based on Chambolle and Pock primal-dual algorithm for solving general convex optimization problems. Diagonal preconditioning is used to ensure the convergence of the algorithm to the global minimum. We consider three robust regularizers liable to provide acceptable results in diffeomorphic registration: Huber, V-Huber and total generalized variation. The Huber norm is used in the image similarity term. The primal-dual equations are derived for the stationary and the non-stationary parameterizations of diffeomorphisms. The resulting algorithms have been implemented for running in the GPU using Cuda. For the most memory consuming methods, we have developed a multi-GPU implementation. The GPU implementations allowed us to perform an exhaustive evaluation study in NIREP and LPBA40 databases. The experiments showed that, for all the considered regularizers, the proposed method converges to diffeomorphic solutions while better preserving discontinuities at the boundaries of the objects compared to baseline diffeomorphic registration methods. In most cases, the evaluation showed a competitive performance for the robust regularizers, close to the performance of the baseline diffeomorphic registration methods.

Elucidating the relation between childhood emotional abuse and depressive symptoms in adulthood: The mediating role of maladaptive interpersonal processes

PubMed Central

Massing-Schaffer, Maya; Liu, Richard T.; Kraines, Morganne A.; Choi, Jimmy Y.; Alloy, Lauren B.

2015-01-01

Objective The purpose of this study is to assess the potential unique and relative mediating effects of three interpersonal risk factors (i.e., excessive reassurance-seeking [ERS], negative feedback seeking [NFS], and rejection sensitivity [RS]) in the relationship between childhood emotional abuse (CEA) and depressive symptoms. Method One hundred eighty-five undergraduates were followed over a four-month interval. Participants completed assessments of childhood abuse history, ERS, NFS, and RS, and depressive symptoms at baseline, as well as depressive symptoms at four-month followup. Results Findings from single-mediator analyses indicated that RS and NFS, but not ERS, mediated the relationship between CEA and prospective depressive symptoms, after accounting for childhood sexual and physical abuse, as well as baseline depressive symptoms. In our multi-mediator model, only RS remained a significant mediator of the relationship between CEA and prospective depressive symptoms. Conclusions The current study provides preliminary evidence that negative behavioral styles may function as a mechanism linking prior experiences of CEA to subsequent depressive symptoms. Clinical implications of these findings suggest that targeting maladaptive behavioral tendencies, particularly RS, may be an effective adjunct in behavioral modification treatments of CEA victims at risk for depression. PMID:26246650

Changes in the Built Environment and Changes in the Amount of Walking Over Time: Longitudinal Results From the Multi-Ethnic Study of Atherosclerosis

PubMed Central

Hirsch, Jana A.; Moore, Kari A.; Clarke, Philippa J.; Rodriguez, Daniel A.; Evenson, Kelly R.; Brines, Shannon J.; Zagorski, Melissa A.; Diez Roux, Ana V.

2014-01-01

Lack of longitudinal research hinders causal inference on the association between the built environment and walking. In the present study, we used data from 6,027 adults in the Multi-Ethnic Study of Atherosclerosis who were 45–84 years of age at baseline to investigate the association of neighborhood built environment with trends in the amount of walking between 2000 and 2012. Walking for transportation and walking for leisure were assessed at baseline and at 3 follow-up visits (median follow-up = 9.15 years). Time-varying built environment measures (measures of population density, land use, number of destinations, bus access, and street connectivity) were created using geographic information systems. We used linear mixed models to estimate the associations between baseline levels of and a change in each built environment feature and a change in the frequency of walking. After adjustment for potential confounders, we found that higher baseline levels of population density, area zoned for retail, social destinations, walking destinations, and street connectivity were associated with greater increases in walking for transportation over time. Higher baseline levels of land zoned for residential use and distance to buses were associated with less pronounced increases (or decreases) in walking for transportation over time. Increases in the number of social destinations, the number of walking destinations, and street connectivity over time were associated with greater increases in walking for transportation. Higher baseline levels of both land zoned for retail and walking destinations were associated with greater increases in leisure walking, but no changes in built environment features were associated with leisure walking. The creation of mixed-use, dense developments may encourage adults to incorporate walking for transportation into their everyday lives. PMID:25234431

Chance-constrained multi-objective optimization of groundwater remediation design at DNAPLs-contaminated sites using a multi-algorithm genetically adaptive method.

PubMed

Ouyang, Qi; Lu, Wenxi; Hou, Zeyu; Zhang, Yu; Li, Shuai; Luo, Jiannan

2017-05-01

In this paper, a multi-algorithm genetically adaptive multi-objective (AMALGAM) method is proposed as a multi-objective optimization solver. It was implemented in the multi-objective optimization of a groundwater remediation design at sites contaminated by dense non-aqueous phase liquids. In this study, there were two objectives: minimization of the total remediation cost, and minimization of the remediation time. A non-dominated sorting genetic algorithm II (NSGA-II) was adopted to compare with the proposed method. For efficiency, the time-consuming surfactant-enhanced aquifer remediation simulation model was replaced by a surrogate model constructed by a multi-gene genetic programming (MGGP) technique. Similarly, two other surrogate modeling methods-support vector regression (SVR) and Kriging (KRG)-were employed to make comparisons with MGGP. In addition, the surrogate-modeling uncertainty was incorporated in the optimization model by chance-constrained programming (CCP). The results showed that, for the problem considered in this study, (1) the solutions obtained by AMALGAM incurred less remediation cost and required less time than those of NSGA-II, indicating that AMALGAM outperformed NSGA-II. It was additionally shown that (2) the MGGP surrogate model was more accurate than SVR and KRG; and (3) the remediation cost and time increased with the confidence level, which can enable decision makers to make a suitable choice by considering the given budget, remediation time, and reliability. Copyright © 2017 Elsevier B.V. All rights reserved.

A method for optimizing multi-objective reservoir operation upon human and riverine ecosystem demands

NASA Astrophysics Data System (ADS)

Ai, Xueshan; Dong, Zuo; Mo, Mingzhu

2017-04-01

The optimal reservoir operation is in generally a multi-objective problem. In real life, most of the reservoir operation optimization problems involve conflicting objectives, for which there is no single optimal solution which can simultaneously gain an optimal result of all the purposes, but rather a set of well distributed non-inferior solutions or Pareto frontier exists. On the other hand, most of the reservoirs operation rules is to gain greater social and economic benefits at the expense of ecological environment, resulting to the destruction of riverine ecology and reduction of aquatic biodiversity. To overcome these drawbacks, this study developed a multi-objective model for the reservoir operating with the conflicting functions of hydroelectric energy generation, irrigation and ecological protection. To solve the model with the objectives of maximize energy production, maximize the water demand satisfaction rate of irrigation and ecology, we proposed a multi-objective optimization method of variable penalty coefficient (VPC), which was based on integrate dynamic programming (DP) with discrete differential dynamic programming (DDDP), to generate a well distributed non-inferior along the Pareto front by changing the penalties coefficient of different objectives. This method was applied to an existing China reservoir named Donggu, through a course of a year, which is a multi-annual storage reservoir with multiple purposes. The case study results showed a good relationship between any two of the objectives and a good Pareto optimal solutions, which provide a reference for the reservoir decision makers.

Distributed Generation Planning using Peer Enhanced Multi-objective Teaching-Learning based Optimization in Distribution Networks

NASA Astrophysics Data System (ADS)

Selvam, Kayalvizhi; Vinod Kumar, D. M.; Siripuram, Ramakanth

2017-04-01

In this paper, an optimization technique called peer enhanced teaching learning based optimization (PeTLBO) algorithm is used in multi-objective problem domain. The PeTLBO algorithm is parameter less so it reduced the computational burden. The proposed peer enhanced multi-objective based TLBO (PeMOTLBO) algorithm has been utilized to find a set of non-dominated optimal solutions [distributed generation (DG) location and sizing in distribution network]. The objectives considered are: real power loss and the voltage deviation subjected to voltage limits and maximum penetration level of DG in distribution network. Since the DG considered is capable of injecting real and reactive power to the distribution network the power factor is considered as 0.85 lead. The proposed peer enhanced multi-objective optimization technique provides different trade-off solutions in order to find the best compromise solution a fuzzy set theory approach has been used. The effectiveness of this proposed PeMOTLBO is tested on IEEE 33-bus and Indian 85-bus distribution system. The performance is validated with Pareto fronts and two performance metrics (C-metric and S-metric) by comparing with robust multi-objective technique called non-dominated sorting genetic algorithm-II and also with the basic TLBO.

Implementation of Multi-Agent Object Attention System Based on Biologically Inspired Attractor Selection

NASA Astrophysics Data System (ADS)

Hashimoto, Ryoji; Matsumura, Tomoya; Nozato, Yoshihiro; Watanabe, Kenji; Onoye, Takao

A multi-agent object attention system is proposed, which is based on biologically inspired attractor selection model. Object attention is facilitated by using a video sequence and a depth map obtained through a compound-eye image sensor TOMBO. Robustness of the multi-agent system over environmental changes is enhanced by utilizing the biological model of adaptive response by attractor selection. To implement the proposed system, an efficient VLSI architecture is employed with reducing enormous computational costs and memory accesses required for depth map processing and multi-agent attractor selection process. According to the FPGA implementation result of the proposed object attention system, which is accomplished by using 7,063 slices, 640×512 pixel input images can be processed in real-time with three agents at a rate of 9fps in 48MHz operation.

Pricing and location decisions in multi-objective facility location problem with M/M/m/k queuing systems

NASA Astrophysics Data System (ADS)

Tavakkoli-Moghaddam, Reza; Vazifeh-Noshafagh, Samira; Taleizadeh, Ata Allah; Hajipour, Vahid; Mahmoudi, Amin

2017-01-01

This article presents a new multi-objective model for a facility location problem with congestion and pricing policies. This model considers situations in which immobile service facilities are congested by a stochastic demand following M/M/m/k queues. The presented model belongs to the class of mixed-integer nonlinear programming models and NP-hard problems. To solve such a hard model, a new multi-objective optimization algorithm based on a vibration theory, namely multi-objective vibration damping optimization (MOVDO), is developed. In order to tune the algorithms parameters, the Taguchi approach using a response metric is implemented. The computational results are compared with those of the non-dominated ranking genetic algorithm and non-dominated sorting genetic algorithm. The outputs demonstrate the robustness of the proposed MOVDO in large-sized problems.

Second-Year Results of an Obesity Prevention Program at The Dow Chemical Company

PubMed Central

Roemer, Enid C.; Pei, Xiaofei; Short, Meghan E.; Tabrizi, Maryam J.; Wilson, Mark G.; DeJoy, David M.; Craun, Beth A.; Tully, Karen J.; White, John M.; Baase, Catherine M.

2010-01-01

Objective Evaluate innovative, evidence-based approaches to organizational/supportive environmental interventions aimed at reducing the prevalence of obesity among Dow employees after two years of implementation. Methods A quasi-experimental study design compared outcomes for two levels of intervention intensity to a control group. Propensity scores were used to weight baseline differences between intervention and control subjects. Difference-in-differences methods and multi-level modeling were used to control for individual and site-level confounders. Results Intervention participants maintained their weight and BMI while control participants gained 1.3 pounds and increased their BMI values by 0.2 over two years. Significant differences in blood pressure and cholesterol values were observed when comparing intervention employees to controls. At higher intensity sites, improvements were more pronounced. Conclusions Environmental interventions at the workplace can support weight management and risk reduction after two years. PMID:20190646

Landlord project multi-year program plan, fiscal year 1999, WBS 1.5

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dallas, M.D.

The MYWP technical baseline describes the work to be accomplished by the Project and the technical standards which govern that work. The mission of Landlord Project is to provide more maintenance replacement of general infrastructure facilities and systems to facilitate the Hanford Site cleanup mission. Also, once an infrastructure facility or system is no longer needed the Landlord Project transitions the facility to final closure/removal through excess, salvage or demolition. Landlord Project activities will be performed in an environmentally sound, safe, economical, prudent, and reliable manner. The Landlord Project consists of the following facilities systems: steam, water, liquid sanitary waste,more » electrical distribution, telecommunication, sanitary landfill, emergency services, general purpose offices, general purpose shops, general purpose warehouses, environmental supports facilities, roads, railroad, and the site land. The objectives for general infrastructure support are reflected in two specific areas, (1) Core Infrastructure Maintenance, and (2) Infrastructure Risk Mitigation.« less

Results of the JIMO Follow-on Destinations Parametric Studies

NASA Technical Reports Server (NTRS)

Noca, Muriel A.; Hack, Kurt J.

2005-01-01

NASA's proposed Jupiter Icy Moon Orbiter (JIMO) mission currently in conceptual development is to be the first one of a series of highly capable Nuclear Electric Propulsion (NEP) science driven missions. To understand the implications of a multi-mission capability requirement on the JIMO vehicle and mission, the NASA Prometheus Program initiated a set of parametric high-level studies to be followed by a series of more in-depth studies. The JIMO potential follow-on destinations identified include a Saturn system tour, a Neptune system tour, a Kuiper Belt Objects rendezvous, an Interstellar Precursor mission, a Multiple Asteroid Sample Return and a Comet Sample Return. This paper shows that the baseline JIMO reactor and design envelop can satisfy five out of six of the follow-on destinations. Flight time to these destinations can significantly be reduced by increasing the launch energy or/and by inserting gravity assists to the heliocentric phase.

Global, Multi-Objective Trajectory Optimization With Parametric Spreading

NASA Technical Reports Server (NTRS)

Vavrina, Matthew A.; Englander, Jacob A.; Phillips, Sean M.; Hughes, Kyle M.

2017-01-01

Mission design problems are often characterized by multiple, competing trajectory optimization objectives. Recent multi-objective trajectory optimization formulations enable generation of globally-optimal, Pareto solutions via a multi-objective genetic algorithm. A byproduct of these formulations is that clustering in design space can occur in evolving the population towards the Pareto front. This clustering can be a drawback, however, if parametric evaluations of design variables are desired. This effort addresses clustering by incorporating operators that encourage a uniform spread over specified design variables while maintaining Pareto front representation. The algorithm is demonstrated on a Neptune orbiter mission, and enhanced multidimensional visualization strategies are presented.

Demographic factors and retrieval of object and proper names after age 70

PubMed Central

Fridkin, Shimon; Ayalon, Liat

2018-01-01

Purpose This research aimed to investigate whether demographic factors are similarly related to retrieval of object and proper names. Methods The sample included 5,907 individuals above age 70 who participated in the Health and Retirement Study between 2004 and 2012. Participants were asked to name two objects as well as the US President and Vice President. Latent growth curve models examined the associations of age, education, and self-rated health with baseline levels and change trajectories in retrieval. Results Age and education were more strongly related to retrieval of proper names than to retrieval of object names, both for baseline scores and for change trajectory. Similar effects of self-rated health emerged for both types of stimuli. Conclusions The results show that examining object names and proper names together as indication of cognitive status in the HRS might overlook important differences between the two types of stimuli, in both baseline performance and longitudinal change. PMID:29370264

Sleep Restriction Therapy for Insomnia is Associated with Reduced Objective Total Sleep Time, Increased Daytime Somnolence, and Objectively Impaired Vigilance: Implications for the Clinical Management of Insomnia Disorder

PubMed Central

Kyle, Simon D.; Miller, Christopher B.; Rogers, Zoe; Siriwardena, A. Niroshan; MacMahon, Kenneth M.; Espie, Colin A.

2014-01-01

Study Objectives: To investigate whether sleep restriction therapy (SRT) is associated with reduced objective total sleep time (TST), increased daytime somnolence, and impaired vigilance. Design: Within-subject, noncontrolled treatment investigation. Setting: Sleep research laboratory. Participants: Sixteen patients [10 female, mean age = 47.1 (10.8) y] with well-defined psychophysiological insomnia (PI), reporting TST ≤ 6 h. Interventions: Patients were treated with single-component SRT over a 4-w protocol, sleeping in the laboratory for 2 nights prior to treatment initiation and for 3 nights (SRT night 1, 8, 22) during the acute interventional phase. The psychomotor vigilance task (PVT) was completed at seven defined time points [day 0 (baseline), day 1,7,8,21,22 (acute treatment) and day 84 (3 mo)]. The Epworth Sleepiness Scale (ESS) was completed at baseline, w 1-4, and 3 mo. Measurement and results: Subjective sleep outcomes and global insomnia severity significantly improved before and after SRT. There was, however, a robust decrease in PSG-defined TST during acute implementation of SRT, by an average of 91 min on night 1, 78 min on night 8, and 69 min on night 22, relative to baseline (P < 0.001; effect size range = 1.60-1.80). During SRT, PVT lapses were significantly increased from baseline (at three of five assessment points, all P < 0.05; effect size range = 0.69-0.78), returning to baseline levels by 3 mo (P = 0.43). A similar pattern was observed for RT, with RTs slowing during acute treatment (at four of five assessment points, all P < 0.05; effect size range = 0.57-0.89) and returning to pretreatment levels at 3 mo (P = 0.78). ESS scores were increased at w 1, 2, and 3 (relative to baseline; all P < 0.05); by 3 mo, sleepiness had returned to baseline (normative) levels (P = 0.65). Conclusion: For the first time we show that acute sleep restriction therapy is associated with reduced objective total sleep time, increased daytime sleepiness, and objective performance impairment. Our data have important implications for implementation guidelines around the safe and effective delivery of cognitive behavioral therapy for insomnia. Citation: Kyle SD; Miller CB; Rogers Z; Siriwardena AN; MacMahon KM; Espie CA. Sleep restriction therapy for insomnia is associated with reduced objective total sleep time, increased daytime somnolence, and objectively impaired vigilance: implications for the clinical management of insomnia disorder. SLEEP 2014;37(2):229-237. PMID:24497651

Dynamic contrast-enhanced MR imaging pharmacokinetic parameters as predictors of treatment response of brain metastases in patients with lung cancer.

PubMed

Kuchcinski, Grégory; Le Rhun, Emilie; Cortot, Alexis B; Drumez, Elodie; Duhal, Romain; Lalisse, Maxime; Dumont, Julien; Lopes, Renaud; Pruvo, Jean-Pierre; Leclerc, Xavier; Delmaire, Christine

2017-09-01

To determine the diagnostic accuracy of pharmacokinetic parameters measured by dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in predicting the response of brain metastases to antineoplastic therapy in patients with lung cancer. Forty-four consecutive patients with lung cancer, harbouring 123 newly diagnosed brain metastases prospectively underwent conventional 3-T MRI at baseline (within 1 month before treatment), during the early (7-10 weeks) and midterm (5-7 months) post-treatment period. An additional DCE MRI sequence was performed during baseline and early post-treatment MRI to evaluate baseline pharmacokinetic parameters (K trans , k ep , v e , v p ) and their early variation (∆K trans , ∆k ep , ∆v e , ∆v p ). The objective response was judged by the volume variation of each metastasis from baseline to midterm MRI. ROC curve analysis determined the best DCE MRI parameter to predict the objective response. Baseline DCE MRI parameters were not associated with the objective response. Early ∆K trans , ∆v e and ∆v p were significantly associated with the objective response (p = 0.02, p = 0.001 and p = 0.02, respectively). The best predictor of objective response was ∆v e with an area under the curve of 0.93 [95% CI = 0.87, 0.99]. DCE MRI and early ∆v e may be a useful tool to predict the objective response of brain metastases in patients with lung cancer. • DCE MRI could predict the response of brain metastases from lung cancer • ∆v e was the best predictor of response • DCE MRI could be used to individualize patients' follow-up.

Baseline modeling of the Owensboro cable-stayed bridge over the Ohio River.

DOT National Transportation Integrated Search

2006-03-01

This report presents the baseline modeling of the Owensboro cable-stayed bridge which connects Owensboro, Kentucky and Rockport, Indiana over the Ohio River. The objective of this study is to establish the bridge baseline model via the dynamics-based...

Segmentation and object-oriented classification of wetlands in a karst Florida landscape using multi-season Landsat-7 ETM+ Imagery

EPA Science Inventory

Segmentation and object-oriented processing of single-season and multi-season Landsat-7 ETM+ data was utilized for the classification of wetlands in a 1560 km2 study area of north central Florida. This segmentation and object-oriented classification outperformed the traditional ...

Multi-object segmentation using coupled nonparametric shape and relative pose priors

NASA Astrophysics Data System (ADS)

Uzunbas, Mustafa Gökhan; Soldea, Octavian; Çetin, Müjdat; Ünal, Gözde; Erçil, Aytül; Unay, Devrim; Ekin, Ahmet; Firat, Zeynep

2009-02-01

We present a new method for multi-object segmentation in a maximum a posteriori estimation framework. Our method is motivated by the observation that neighboring or coupling objects in images generate configurations and co-dependencies which could potentially aid in segmentation if properly exploited. Our approach employs coupled shape and inter-shape pose priors that are computed using training images in a nonparametric multi-variate kernel density estimation framework. The coupled shape prior is obtained by estimating the joint shape distribution of multiple objects and the inter-shape pose priors are modeled via standard moments. Based on such statistical models, we formulate an optimization problem for segmentation, which we solve by an algorithm based on active contours. Our technique provides significant improvements in the segmentation of weakly contrasted objects in a number of applications. In particular for medical image analysis, we use our method to extract brain Basal Ganglia structures, which are members of a complex multi-object system posing a challenging segmentation problem. We also apply our technique to the problem of handwritten character segmentation. Finally, we use our method to segment cars in urban scenes.

Multi-objective optimisation and decision-making of space station logistics strategies

NASA Astrophysics Data System (ADS)

Zhu, Yue-he; Luo, Ya-zhong

2016-10-01

Space station logistics strategy optimisation is a complex engineering problem with multiple objectives. Finding a decision-maker-preferred compromise solution becomes more significant when solving such a problem. However, the designer-preferred solution is not easy to determine using the traditional method. Thus, a hybrid approach that combines the multi-objective evolutionary algorithm, physical programming, and differential evolution (DE) algorithm is proposed to deal with the optimisation and decision-making of space station logistics strategies. A multi-objective evolutionary algorithm is used to acquire a Pareto frontier and help determine the range parameters of the physical programming. Physical programming is employed to convert the four-objective problem into a single-objective problem, and a DE algorithm is applied to solve the resulting physical programming-based optimisation problem. Five kinds of objective preference are simulated and compared. The simulation results indicate that the proposed approach can produce good compromise solutions corresponding to different decision-makers' preferences.

Potential Landslide Early Detection Near Wenchuan by a Qualitatively Multi-Baseline Dinsar Method

NASA Astrophysics Data System (ADS)

Dai, K.; Chen, G.; Xu, Q.; Li, Z.; Qu, T.; Hu, L.; Lu, H.

2018-04-01

Early detection of landslides is important for disaster prevention, which was still very hard work with traditional surveying methods. Interferometric Synthetic Aperture Radar (InSAR) technology provided us the ability to monitor displacements along the slope with wide coverage and high accuracy. In this paper, we proposed a qualitatively multi-baseline DInSAR method to early detect and map the potential landslides. Two sections of China National Highway 317 and 213 were selected as study area. With this method 10 potential landslide areas were early detected and mapped in a quick and effective way. One of them (i.e. Shidaguan landslide) collapsed on August 2017, which was coincident with our results, suggesting that this method could become an effective way to acquire the landslide early detection map to assist the future disaster prevention work.

Expansion of Pathogen-Specific Mono- and Multifunctional Th1 and Th17 Cells in Multi-Focal Tuberculous Lymphadenitis

PubMed Central

Kumar, Nathella Pavan; Sridhar, Rathinam; Banurekha, Vaithilingam V.; Nair, Dina; Jawahar, Mohideen S.; Nutman, Thomas B.; Babu, Subash

2013-01-01

Background Th1 and Th17 responses are known to play an important role in immunity to pulmonary tuberculosis (PTB), although little is known about their role in extrapulmonary forms of tuberculosis (TB). Methods To identify the role of Th1, Th17, and Th22 cells in multi-focal TB lymphadenitis (TBL), we examined mycobacteria–specific immune responses in the whole blood of individuals with PTB (n = 20) and compared them with those with TBL (n = 25). Results Elevated frequencies of CD4+ T cells expressing IFN- γ, TNF-α, and IL-2 were present in individuals with TBL compared with those with PTB at baseline and in response to ESAT-6 and CFP-10. Similarly, increased frequencies of CD4+ T cells expressing IL-17A, IL-17F, and IFN-γ were also present in individuals with TBL at baseline and following ESAT-6 and CFP-10 stimulation although no significant difference in frequency of Th22 cells was observed. Finally, frequencies of Th1 (but not Th17) cells exhibited a significantly negative correlation with natural regulatory T cell frequencies at baseline. Conclusions Multi-focal TB lymphadenitis is therefore characterized by elevated frequencies of Th1 and Th17 cells, indicating that Th1 and Th17 responses in TB disease are probably correlates of disease severity rather than of protective immunity. PMID:23451159

Multi-objective optimization in spatial planning: Improving the effectiveness of multi-objective evolutionary algorithms (non-dominated sorting genetic algorithm II)

NASA Astrophysics Data System (ADS)

Karakostas, Spiros

2015-05-01

The multi-objective nature of most spatial planning initiatives and the numerous constraints that are introduced in the planning process by decision makers, stakeholders, etc., synthesize a complex spatial planning context in which the concept of solid and meaningful optimization is a unique challenge. This article investigates new approaches to enhance the effectiveness of multi-objective evolutionary algorithms (MOEAs) via the adoption of a well-known metaheuristic: the non-dominated sorting genetic algorithm II (NSGA-II). In particular, the contribution of a sophisticated crossover operator coupled with an enhanced initialization heuristic is evaluated against a series of metrics measuring the effectiveness of MOEAs. Encouraging results emerge for both the convergence rate of the evolutionary optimization process and the occupation of valuable regions of the objective space by non-dominated solutions, facilitating the work of spatial planners and decision makers. Based on the promising behaviour of both heuristics, topics for further research are proposed to improve their effectiveness.

Real-Time Visual Tracking through Fusion Features

PubMed Central

Ruan, Yang; Wei, Zhenzhong

2016-01-01

Due to their high-speed, correlation filters for object tracking have begun to receive increasing attention. Traditional object trackers based on correlation filters typically use a single type of feature. In this paper, we attempt to integrate multiple feature types to improve the performance, and we propose a new DD-HOG fusion feature that consists of discriminative descriptors (DDs) and histograms of oriented gradients (HOG). However, fusion features as multi-vector descriptors cannot be directly used in prior correlation filters. To overcome this difficulty, we propose a multi-vector correlation filter (MVCF) that can directly convolve with a multi-vector descriptor to obtain a single-channel response that indicates the location of an object. Experiments on the CVPR2013 tracking benchmark with the evaluation of state-of-the-art trackers show the effectiveness and speed of the proposed method. Moreover, we show that our MVCF tracker, which uses the DD-HOG descriptor, outperforms the structure-preserving object tracker (SPOT) in multi-object tracking because of its high-speed and ability to address heavy occlusion. PMID:27347951

A lexicographic weighted Tchebycheff approach for multi-constrained multi-objective optimization of the surface grinding process

NASA Astrophysics Data System (ADS)

Khalilpourazari, Soheyl; Khalilpourazary, Saman

2017-05-01

In this article a multi-objective mathematical model is developed to minimize total time and cost while maximizing the production rate and surface finish quality in the grinding process. The model aims to determine optimal values of the decision variables considering process constraints. A lexicographic weighted Tchebycheff approach is developed to obtain efficient Pareto-optimal solutions of the problem in both rough and finished conditions. Utilizing a polyhedral branch-and-cut algorithm, the lexicographic weighted Tchebycheff model of the proposed multi-objective model is solved using GAMS software. The Pareto-optimal solutions provide a proper trade-off between conflicting objective functions which helps the decision maker to select the best values for the decision variables. Sensitivity analyses are performed to determine the effect of change in the grain size, grinding ratio, feed rate, labour cost per hour, length of workpiece, wheel diameter and downfeed of grinding parameters on each value of the objective function.

Pareto-optimal multi-objective dimensionality reduction deep auto-encoder for mammography classification.

PubMed

Taghanaki, Saeid Asgari; Kawahara, Jeremy; Miles, Brandon; Hamarneh, Ghassan

2017-07-01

Feature reduction is an essential stage in computer aided breast cancer diagnosis systems. Multilayer neural networks can be trained to extract relevant features by encoding high-dimensional data into low-dimensional codes. Optimizing traditional auto-encoders works well only if the initial weights are close to a proper solution. They are also trained to only reduce the mean squared reconstruction error (MRE) between the encoder inputs and the decoder outputs, but do not address the classification error. The goal of the current work is to test the hypothesis that extending traditional auto-encoders (which only minimize reconstruction error) to multi-objective optimization for finding Pareto-optimal solutions provides more discriminative features that will improve classification performance when compared to single-objective and other multi-objective approaches (i.e. scalarized and sequential). In this paper, we introduce a novel multi-objective optimization of deep auto-encoder networks, in which the auto-encoder optimizes two objectives: MRE and mean classification error (MCE) for Pareto-optimal solutions, rather than just MRE. These two objectives are optimized simultaneously by a non-dominated sorting genetic algorithm. We tested our method on 949 X-ray mammograms categorized into 12 classes. The results show that the features identified by the proposed algorithm allow a classification accuracy of up to 98.45%, demonstrating favourable accuracy over the results of state-of-the-art methods reported in the literature. We conclude that adding the classification objective to the traditional auto-encoder objective and optimizing for finding Pareto-optimal solutions, using evolutionary multi-objective optimization, results in producing more discriminative features. Copyright © 2017 Elsevier B.V. All rights reserved.

Development of a Dynamically Configurable, Object-Oriented Framework for Distributed, Multi-modal Computational Aerospace Systems Simulation

NASA Technical Reports Server (NTRS)

Afjeh, Abdollah A.; Reed, John A.

2003-01-01

The following reports are presented on this project:A first year progress report on: Development of a Dynamically Configurable,Object-Oriented Framework for Distributed, Multi-modal Computational Aerospace Systems Simulation; A second year progress report on: Development of a Dynamically Configurable, Object-Oriented Framework for Distributed, Multi-modal Computational Aerospace Systems Simulation; An Extensible, Interchangeable and Sharable Database Model for Improving Multidisciplinary Aircraft Design; Interactive, Secure Web-enabled Aircraft Engine Simulation Using XML Databinding Integration; and Improving the Aircraft Design Process Using Web-based Modeling and Simulation.

A multi-objective framework to predict flows of ungauged rivers within regions of sparse hydrometeorologic observation

NASA Astrophysics Data System (ADS)

Alipour, M.; Kibler, K. M.

2017-12-01

Despite advances in flow prediction, managers of ungauged rivers located within broad regions of sparse hydrometeorologic observation still lack prescriptive methods robust to the data challenges of such regions. We propose a multi-objective streamflow prediction framework for regions of minimum observation to select models that balance runoff efficiency with choice of accurate parameter values. We supplement sparse observed data with uncertain or low-resolution information incorporated as `soft' a priori parameter estimates. The performance of the proposed framework is tested against traditional single-objective and constrained single-objective calibrations in two catchments in a remote area of southwestern China. We find that the multi-objective approach performs well with respect to runoff efficiency in both catchments (NSE = 0.74 and 0.72), within the range of efficiencies returned by other models (NSE = 0.67 - 0.78). However, soil moisture capacity estimated by the multi-objective model resonates with a priori estimates (parameter residuals of 61 cm versus 289 and 518 cm for maximum soil moisture capacity in one catchment, and 20 cm versus 246 and 475 cm in the other; parameter residuals of 0.48 versus 0.65 and 0.7 for soil moisture distribution shape factor in one catchment, and 0.91 versus 0.79 and 1.24 in the other). Thus, optimization to a multi-criteria objective function led to very different representations of soil moisture capacity as compared to models selected by single-objective calibration, without compromising runoff efficiency. These different soil moisture representations may translate into considerably different hydrological behaviors. The proposed approach thus offers a preliminary step towards greater process understanding in regions of severe data limitations. For instance, the multi-objective framework may be an adept tool to discern between models of similar efficiency to select models that provide the "right answers for the right reasons". Managers may feel more confident to utilize such models to predict flows in fully ungauged areas.

Buildings Change Detection Based on Shape Matching for Multi-Resolution Remote Sensing Imagery

NASA Astrophysics Data System (ADS)

Abdessetar, M.; Zhong, Y.

2017-09-01

Buildings change detection has the ability to quantify the temporal effect, on urban area, for urban evolution study or damage assessment in disaster cases. In this context, changes analysis might involve the utilization of the available satellite images with different resolutions for quick responses. In this paper, to avoid using traditional method with image resampling outcomes and salt-pepper effect, building change detection based on shape matching is proposed for multi-resolution remote sensing images. Since the object's shape can be extracted from remote sensing imagery and the shapes of corresponding objects in multi-scale images are similar, it is practical for detecting buildings changes in multi-scale imagery using shape analysis. Therefore, the proposed methodology can deal with different pixel size for identifying new and demolished buildings in urban area using geometric properties of objects of interest. After rectifying the desired multi-dates and multi-resolutions images, by image to image registration with optimal RMS value, objects based image classification is performed to extract buildings shape from the images. Next, Centroid-Coincident Matching is conducted, on the extracted building shapes, based on the Euclidean distance measurement between shapes centroid (from shape T0 to shape T1 and vice versa), in order to define corresponding building objects. Then, New and Demolished buildings are identified based on the obtained distances those are greater than RMS value (No match in the same location).

Collaborative real-time scheduling of multiple PTZ cameras for multiple object tracking in video surveillance

NASA Astrophysics Data System (ADS)

Liu, Yu-Che; Huang, Chung-Lin

2013-03-01

This paper proposes a multi-PTZ-camera control mechanism to acquire close-up imagery of human objects in a surveillance system. The control algorithm is based on the output of multi-camera, multi-target tracking. Three main concerns of the algorithm are (1) the imagery of human object's face for biometric purposes, (2) the optimal video quality of the human objects, and (3) minimum hand-off time. Here, we define an objective function based on the expected capture conditions such as the camera-subject distance, pan tile angles of capture, face visibility and others. Such objective function serves to effectively balance the number of captures per subject and quality of captures. In the experiments, we demonstrate the performance of the system which operates in real-time under real world conditions on three PTZ cameras.

Baseline modeling of the Maysville cable-stayed bridge over the Ohio River.

DOT National Transportation Integrated Search

2005-07-01

This report presents the baseline modeling of the Maysville cable-stayed bridge which connects Maysville, Kentucky and Aberdeen, Ohio over the Ohio River. The objective of this study is to establish the bridge baseline model via the dynamics-based te...

SU-F-R-10: Selecting the Optimal Solution for Multi-Objective Radiomics Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, Z; Folkert, M; Wang, J

2016-06-15

Purpose: To develop an evidential reasoning approach for selecting the optimal solution from a Pareto solution set obtained by a multi-objective radiomics model for predicting distant failure in lung SBRT. Methods: In the multi-objective radiomics model, both sensitivity and specificity are considered as the objective functions simultaneously. A Pareto solution set with many feasible solutions will be resulted from the multi-objective optimization. In this work, an optimal solution Selection methodology for Multi-Objective radiomics Learning model using the Evidential Reasoning approach (SMOLER) was proposed to select the optimal solution from the Pareto solution set. The proposed SMOLER method used the evidentialmore » reasoning approach to calculate the utility of each solution based on pre-set optimal solution selection rules. The solution with the highest utility was chosen as the optimal solution. In SMOLER, an optimal learning model coupled with clonal selection algorithm was used to optimize model parameters. In this study, PET, CT image features and clinical parameters were utilized for predicting distant failure in lung SBRT. Results: Total 126 solution sets were generated by adjusting predictive model parameters. Each Pareto set contains 100 feasible solutions. The solution selected by SMOLER within each Pareto set was compared to the manually selected optimal solution. Five-cross-validation was used to evaluate the optimal solution selection accuracy of SMOLER. The selection accuracies for five folds were 80.00%, 69.23%, 84.00%, 84.00%, 80.00%, respectively. Conclusion: An optimal solution selection methodology for multi-objective radiomics learning model using the evidential reasoning approach (SMOLER) was proposed. Experimental results show that the optimal solution can be found in approximately 80% cases.« less

Considering Decision Variable Diversity in Multi-Objective Optimization: Application in Hydrologic Model Calibration

NASA Astrophysics Data System (ADS)

Sahraei, S.; Asadzadeh, M.

2017-12-01

Any modern multi-objective global optimization algorithm should be able to archive a well-distributed set of solutions. While the solution diversity in the objective space has been explored extensively in the literature, little attention has been given to the solution diversity in the decision space. Selection metrics such as the hypervolume contribution and crowding distance calculated in the objective space would guide the search toward solutions that are well-distributed across the objective space. In this study, the diversity of solutions in the decision-space is used as the main selection criteria beside the dominance check in multi-objective optimization. To this end, currently archived solutions are clustered in the decision space and the ones in less crowded clusters are given more chance to be selected for generating new solution. The proposed approach is first tested on benchmark mathematical test problems. Second, it is applied to a hydrologic model calibration problem with more than three objective functions. Results show that the chance of finding more sparse set of high-quality solutions increases, and therefore the analyst would receive a well-diverse set of options with maximum amount of information. Pareto Archived-Dynamically Dimensioned Search, which is an efficient and parsimonious multi-objective optimization algorithm for model calibration, is utilized in this study.

Integrative systems modeling and multi-objective optimization

EPA Science Inventory

This presentation presents a number of algorithms, tools, and methods for utilizing multi-objective optimization within integrated systems modeling frameworks. We first present innovative methods using a genetic algorithm to optimally calibrate the VELMA and SWAT ecohydrological ...

A Novel Sky-Subtraction Method Based on Non-negative Matrix Factorisation with Sparsity for Multi-object Fibre Spectroscopy

NASA Astrophysics Data System (ADS)

Zhang, Bo; Zhang, Long; Ye, Zhongfu

2016-12-01

A novel sky-subtraction method based on non-negative matrix factorisation with sparsity is proposed in this paper. The proposed non-negative matrix factorisation with sparsity method is redesigned for sky-subtraction considering the characteristics of the skylights. It has two constraint terms, one for sparsity and the other for homogeneity. Different from the standard sky-subtraction techniques, such as the B-spline curve fitting methods and the Principal Components Analysis approaches, sky-subtraction based on non-negative matrix factorisation with sparsity method has higher accuracy and flexibility. The non-negative matrix factorisation with sparsity method has research value for the sky-subtraction on multi-object fibre spectroscopic telescope surveys. To demonstrate the effectiveness and superiority of the proposed algorithm, experiments are performed on Large Sky Area Multi-Object Fiber Spectroscopic Telescope data, as the mechanisms of the multi-object fibre spectroscopic telescopes are similar.

Multi-objective game-theory models for conflict analysis in reservoir watershed management.

PubMed

Lee, Chih-Sheng

2012-05-01

This study focuses on the development of a multi-objective game-theory model (MOGM) for balancing economic and environmental concerns in reservoir watershed management and for assistance in decision. Game theory is used as an alternative tool for analyzing strategic interaction between economic development (land use and development) and environmental protection (water-quality protection and eutrophication control). Geographic information system is used to concisely illustrate and calculate the areas of various land use types. The MOGM methodology is illustrated in a case study of multi-objective watershed management in the Tseng-Wen reservoir, Taiwan. The innovation and advantages of MOGM can be seen in the results, which balance economic and environmental concerns in watershed management and which can be interpreted easily by decision makers. For comparison, the decision-making process using conventional multi-objective method to produce many alternatives was found to be more difficult. Copyright © 2012 Elsevier Ltd. All rights reserved.

Automatic Clustering Using Multi-objective Particle Swarm and Simulated Annealing

PubMed Central

Abubaker, Ahmad; Baharum, Adam; Alrefaei, Mahmoud

2015-01-01

This paper puts forward a new automatic clustering algorithm based on Multi-Objective Particle Swarm Optimization and Simulated Annealing, “MOPSOSA”. The proposed algorithm is capable of automatic clustering which is appropriate for partitioning datasets to a suitable number of clusters. MOPSOSA combines the features of the multi-objective based particle swarm optimization (PSO) and the Multi-Objective Simulated Annealing (MOSA). Three cluster validity indices were optimized simultaneously to establish the suitable number of clusters and the appropriate clustering for a dataset. The first cluster validity index is centred on Euclidean distance, the second on the point symmetry distance, and the last cluster validity index is based on short distance. A number of algorithms have been compared with the MOPSOSA algorithm in resolving clustering problems by determining the actual number of clusters and optimal clustering. Computational experiments were carried out to study fourteen artificial and five real life datasets. PMID:26132309

Multi-Object Spectroscopy with MUSE

NASA Astrophysics Data System (ADS)

Kelz, A.; Kamann, S.; Urrutia, T.; Weilbacher, P.; Bacon, R.

2016-10-01

Since 2014, MUSE, the Multi-Unit Spectroscopic Explorer, is in operation at the ESO-VLT. It combines a superb spatial sampling with a large wavelength coverage. By design, MUSE is an integral-field instrument, but its field-of-view and large multiplex make it a powerful tool for multi-object spectroscopy too. Every data-cube consists of 90,000 image-sliced spectra and 3700 monochromatic images. In autumn 2014, the observing programs with MUSE have commenced, with targets ranging from distant galaxies in the Hubble Deep Field to local stellar populations, star formation regions and globular clusters. This paper provides a brief summary of the key features of the MUSE instrument and its complex data reduction software. Some selected examples are given, how multi-object spectroscopy for hundreds of continuum and emission-line objects can be obtained in wide, deep and crowded fields with MUSE, without the classical need for any target pre-selection.

Image Segmentation Method Using Fuzzy C Mean Clustering Based on Multi-Objective Optimization

NASA Astrophysics Data System (ADS)

Chen, Jinlin; Yang, Chunzhi; Xu, Guangkui; Ning, Li

2018-04-01

Image segmentation is not only one of the hottest topics in digital image processing, but also an important part of computer vision applications. As one kind of image segmentation algorithms, fuzzy C-means clustering is an effective and concise segmentation algorithm. However, the drawback of FCM is that it is sensitive to image noise. To solve the problem, this paper designs a novel fuzzy C-mean clustering algorithm based on multi-objective optimization. We add a parameter λ to the fuzzy distance measurement formula to improve the multi-objective optimization. The parameter λ can adjust the weights of the pixel local information. In the algorithm, the local correlation of neighboring pixels is added to the improved multi-objective mathematical model to optimize the clustering cent. Two different experimental results show that the novel fuzzy C-means approach has an efficient performance and computational time while segmenting images by different type of noises.

Multi-target detection and positioning in crowds using multiple camera surveillance

NASA Astrophysics Data System (ADS)

Huang, Jiahu; Zhu, Qiuyu; Xing, Yufeng

2018-04-01

In this study, we propose a pixel correspondence algorithm for positioning in crowds based on constraints on the distance between lines of sight, grayscale differences, and height in a world coordinates system. First, a Gaussian mixture model is used to obtain the background and foreground from multi-camera videos. Second, the hair and skin regions are extracted as regions of interest. Finally, the correspondences between each pixel in the region of interest are found under multiple constraints and the targets are positioned by pixel clustering. The algorithm can provide appropriate redundancy information for each target, which decreases the risk of losing targets due to a large viewing angle and wide baseline. To address the correspondence problem for multiple pixels, we construct a pixel-based correspondence model based on a similar permutation matrix, which converts the correspondence problem into a linear programming problem where a similar permutation matrix is found by minimizing an objective function. The correct pixel correspondences can be obtained by determining the optimal solution of this linear programming problem and the three-dimensional position of the targets can also be obtained by pixel clustering. Finally, we verified the algorithm with multiple cameras in experiments, which showed that the algorithm has high accuracy and robustness.

Reality of obesity paradox: Results of percutaneous coronary intervention in Middle Eastern patients.

PubMed

Jarrah, Mohamad; Hammoudeh, Ayman J; Khader, Yousef; Tabbalat, Ramzi; Al-Mousa, Eyas; Okkeh, Osama; Alhaddad, Imad A; Tawalbeh, Loai Issa; Hweidi, Issa M

2018-04-01

Objective The aim of this study was to assess the baseline clinical characteristics, coronary angiographic features, and adverse cardiovascular events during hospitalization and at 1 year of follow-up in obese patients compared with overweight and normal/underweight patients. Methods A prospective, multicenter study of consecutive patients undergoing percutaneous coronary intervention was performed. Results Of 2425 enrolled patients, 699 (28.8%) were obese, 1178 (48.6%) were overweight, and 548 (22.6%) were normal/underweight. Obese patients were more likely to be female and to have a higher prevalence of diabetes, hypertension, hypercholesterolemia, or previous percutaneous coronary intervention. Acute coronary syndrome was the indication for percutaneous coronary intervention in 77.0% of obese, 76.4% of overweight, and 77.4% of normal/underweight patients. No significant differences in the prevalence of multi-vessel coronary artery disease or multi-vessel percutaneous coronary intervention were found among the three groups. Additionally, no significant differences were found in stent thrombosis, readmission bleeding rates, or cardiac mortality among the three groups during hospitalization, at 1 month, and at 1 year. Conclusion The major adverse cardiovascular event rate was the same among the three groups throughout the study period. Accordingly, body mass index is considered a weak risk factor for cardiovascular comorbidities in Arab Jordanian patients.

Physician satisfaction with a multi-platform digital scheduling system

PubMed Central

Rocha, Leonardo Lima; Lima, Alex Heitor; Santiago, Caroline Reis Maia; Terra, Jose Cláudio Cyrineu; Dagan, Alon; Celi, Leo Anthony

2017-01-01

Objective Physician shift schedules are regularly created manually, using paper or a shared online spreadsheet. Mistakes are not unusual, leading to last minute scrambles to cover a shift. We developed a web-based shift scheduling system and a mobile application tool to facilitate both the monthly scheduling and shift exchanges between physicians. The primary objective was to compare physician satisfaction before and after the mobile application implementation. Methods Over a 9-month period, three surveys, using the 4-point Likert type scale were performed to assess the physician satisfaction. The first survey was conducted three months prior mobile application release, a second survey three months after implementation and the last survey six months after. Results 51 (77%) of the physicians answered the baseline survey. Of those, 32 (63%) were males with a mean age of 37.8 ± 5.5 years. Prior to the mobile application implementation, 36 (70%) of the responders were using more than one method to carry out shift exchanges and only 20 (40%) were using the official department report sheet to document shift exchanges. The second and third survey were answered by 48 (73%) physicians. Forty-eight (98%) of them found the mobile application easy or very easy to install and 47 (96%) did not want to go back to the previous method. Regarding physician satisfaction, at baseline 37% of the physicians were unsatisfied or very unsatisfied with shift scheduling. After the mobile application was implementation, only 4% reported being unsatisfied (OR = 0.11, p < 0.001). The satisfaction level improved from 63% to 96% between the first and the last survey. Satisfaction levels significantly increased between the three time points (OR = 13.33, p < 0.001). Conclusion Our web and mobile phone-based scheduling system resulted in better physician satisfaction. PMID:28328958

Petascale Diagnostic Assessment of the Global Portfolio Rainfall Space Missions' Ability to Support Flood Forecasting

NASA Astrophysics Data System (ADS)

Reed, P. M.; Chaney, N.; Herman, J. D.; Wood, E. F.; Ferringer, M. P.

2015-12-01

This research represents a multi-institutional collaboration between Cornell University, The Aerospace Corporation, and Princeton University that has completed a Petascale diagnostic assessment of the current 10 satellite missions providing rainfall observations. Our diagnostic assessment has required four core tasks: (1) formally linking high-resolution astrodynamics design and coordination of space assets with their global hydrological impacts within a Petascale "many-objective" global optimization framework, (2) developing a baseline diagnostic evaluation of a 1-degree resolution global implementation of the Variable Infiltration Capacity (VIC) model to establish the required satellite observation frequencies and coverage to maintain acceptable global flood forecasts, (3) evaluating the limitations and vulnerabilities of the full suite of current satellite precipitation missions including the recently approved Global Precipitation Measurement (GPM) mission, and (4) conceptualizing the next generation spaced-based platforms for water cycle observation. Our team exploited over 100 Million hours of computing access on the 700,000+ core Blue Waters machine to radically advance our ability to discover and visualize key system tradeoffs and sensitivities. This project represents to our knowledge the first attempt to develop a 10,000 member Monte Carlo global hydrologic simulation at one degree resolution that characterizes the uncertain effects of changing the available frequencies of satellite precipitation on drought and flood forecasts. The simulation—optimization components of the work have set a theoretical baseline for the best possible frequencies and coverages for global precipitation given unlimited investment, broad international coordination in reconfiguring existing assets, and new satellite constellation design objectives informed directly by key global hydrologic forecasting requirements. Our research poses a step towards realizing the integrated global water cycle observatory long sought by the World Climate Research Programme, which has to date eluded the world's space agencies.

Do descriptive norms related to parents and friends predict fruit and vegetable intake similarly among 11-year-old girls and boys?

PubMed

Lehto, Elviira; Ray, Carola; Haukkala, Ari; Yngve, Agneta; Thorsdottir, Inga; Roos, Eva

2016-01-14

We examined whether there are sex differences in children's fruit and vegetable (FV) intake and in descriptive norms (i.e. perceived FV intake) related to parents and friends. We also studied whether friends' impact is as important as that of parents on children's FV intake. Data from the PRO GREENS project in Finland were obtained from 424 children at the age 11 years at baseline. At baseline, 2009 children filled in a questionnaire about descriptive norms conceptualised as perceived FV intake of their parents and friends. They also filled in a validated FFQ that assessed their FV intake both at baseline and in the follow-up in 2010. The associations were examined with multi-level regression analyses with multi-group comparisons. Girls reported higher perceived FV intake of friends and higher own fruit intake at baseline, compared with boys, and higher vegetable intake both at baseline and in the follow-up. Perceived FV intake of parents and friends was positively associated with both girls' and boys' FV intake in both study years. The impact of perceived fruit intake of the mother was stronger among boys. The change in children's FV intake was affected only by perceived FV intake of father and friends. No large sex differences in descriptive norms were found, but the impact of friends on children's FV intake can generally be considered as important as that of parents. Future interventions could benefit from taking into account friends' impact as role models on children's FV intake.

A modified multi-objective particle swarm optimization approach and its application to the design of a deepwater composite riser

NASA Astrophysics Data System (ADS)

Zheng, Y.; Chen, J.

2017-09-01

A modified multi-objective particle swarm optimization method is proposed for obtaining Pareto-optimal solutions effectively. Different from traditional multi-objective particle swarm optimization methods, Kriging meta-models and the trapezoid index are introduced and integrated with the traditional one. Kriging meta-models are built to match expensive or black-box functions. By applying Kriging meta-models, function evaluation numbers are decreased and the boundary Pareto-optimal solutions are identified rapidly. For bi-objective optimization problems, the trapezoid index is calculated as the sum of the trapezoid's area formed by the Pareto-optimal solutions and one objective axis. It can serve as a measure whether the Pareto-optimal solutions converge to the Pareto front. Illustrative examples indicate that to obtain Pareto-optimal solutions, the method proposed needs fewer function evaluations than the traditional multi-objective particle swarm optimization method and the non-dominated sorting genetic algorithm II method, and both the accuracy and the computational efficiency are improved. The proposed method is also applied to the design of a deepwater composite riser example in which the structural performances are calculated by numerical analysis. The design aim was to enhance the tension strength and minimize the cost. Under the buckling constraint, the optimal trade-off of tensile strength and material volume is obtained. The results demonstrated that the proposed method can effectively deal with multi-objective optimizations with black-box functions.

Multi-objective optimization in systematic conservation planning and the representation of genetic variability among populations.

PubMed

Schlottfeldt, S; Walter, M E M T; Carvalho, A C P L F; Soares, T N; Telles, M P C; Loyola, R D; Diniz-Filho, J A F

2015-06-18

Biodiversity crises have led scientists to develop strategies for achieving conservation goals. The underlying principle of these strategies lies in systematic conservation planning (SCP), in which there are at least 2 conflicting objectives, making it a good candidate for multi-objective optimization. Although SCP is typically applied at the species level (or hierarchically higher), it can be used at lower hierarchical levels, such as using alleles as basic units for analysis, for conservation genetics. Here, we propose a method of SCP using a multi-objective approach. We used non-dominated sorting genetic algorithm II in order to identify the smallest set of local populations of Dipteryx alata (baru) (a Brazilian Cerrado species) for conservation, representing the known genetic diversity and using allele frequency information associated with heterozygosity and Hardy-Weinberg equilibrium. We worked in 3 variations for the problem. First, we reproduced a previous experiment, but using a multi-objective approach. We found that the smallest set of populations needed to represent all alleles under study was 7, corroborating the results of the previous study, but with more distinct solutions. In the 2nd and 3rd variations, we performed simultaneous optimization of 4 and 5 objectives, respectively. We found similar but refined results for 7 populations, and a larger portfolio considering intra-specific diversity and persistence with populations ranging from 8-22. This is the first study to apply multi-objective algorithms to an SCP problem using alleles at the population level as basic units for analysis.

Robust Dynamic Multi-objective Vehicle Routing Optimization Method.

PubMed

Guo, Yi-Nan; Cheng, Jian; Luo, Sha; Gong, Dun-Wei

2017-03-21

For dynamic multi-objective vehicle routing problems, the waiting time of vehicle, the number of serving vehicles, the total distance of routes were normally considered as the optimization objectives. Except for above objectives, fuel consumption that leads to the environmental pollution and energy consumption was focused on in this paper. Considering the vehicles' load and the driving distance, corresponding carbon emission model was built and set as an optimization objective. Dynamic multi-objective vehicle routing problems with hard time windows and randomly appeared dynamic customers, subsequently, were modeled. In existing planning methods, when the new service demand came up, global vehicle routing optimization method was triggered to find the optimal routes for non-served customers, which was time-consuming. Therefore, robust dynamic multi-objective vehicle routing method with two-phase is proposed. Three highlights of the novel method are: (i) After finding optimal robust virtual routes for all customers by adopting multi-objective particle swarm optimization in the first phase, static vehicle routes for static customers are formed by removing all dynamic customers from robust virtual routes in next phase. (ii)The dynamically appeared customers append to be served according to their service time and the vehicles' statues. Global vehicle routing optimization is triggered only when no suitable locations can be found for dynamic customers. (iii)A metric measuring the algorithms' robustness is given. The statistical results indicated that the routes obtained by the proposed method have better stability and robustness, but may be sub-optimum. Moreover, time-consuming global vehicle routing optimization is avoided as dynamic customers appear.

a Heuristic Approach for Multi Objective Distribution Feeder Reconfiguration: Using Fuzzy Sets in Normalization of Objective Functions

NASA Astrophysics Data System (ADS)

Milani, Armin Ebrahimi; Haghifam, Mahmood Reza

2008-10-01

The reconfiguration is an operation process used for optimization with specific objectives by means of changing the status of switches in a distribution network. In this paper each objectives is normalized with inspiration from fuzzy sets-to cause optimization more flexible- and formulized as a unique multi-objective function. The genetic algorithm is used for solving the suggested model, in which there is no risk of non-liner objective functions and constraints. The effectiveness of the proposed method is demonstrated through the examples.

Scheduling for the National Hockey League Using a Multi-objective Evolutionary Algorithm

NASA Astrophysics Data System (ADS)

Craig, Sam; While, Lyndon; Barone, Luigi

We describe a multi-objective evolutionary algorithm that derives schedules for the National Hockey League according to three objectives: minimising the teams' total travel, promoting equity in rest time between games, and minimising long streaks of home or away games. Experiments show that the system is able to derive schedules that beat the 2008-9 NHL schedule in all objectives simultaneously, and that it returns a set of schedules that offer a range of trade-offs across the objectives.

Multi-Object Tracking with Correlation Filter for Autonomous Vehicle.

PubMed

Zhao, Dawei; Fu, Hao; Xiao, Liang; Wu, Tao; Dai, Bin

2018-06-22

Multi-object tracking is a crucial problem for autonomous vehicle. Most state-of-the-art approaches adopt the tracking-by-detection strategy, which is a two-step procedure consisting of the detection module and the tracking module. In this paper, we improve both steps. We improve the detection module by incorporating the temporal information, which is beneficial for detecting small objects. For the tracking module, we propose a novel compressed deep Convolutional Neural Network (CNN) feature based Correlation Filter tracker. By carefully integrating these two modules, the proposed multi-object tracking approach has the ability of re-identification (ReID) once the tracked object gets lost. Extensive experiments were performed on the KITTI and MOT2015 tracking benchmarks. Results indicate that our approach outperforms most state-of-the-art tracking approaches.

Randomised controlled feasibility study of a school-based multi-level intervention to increase physical activity and decrease sedentary behaviour among vocational school students.

PubMed

Hankonen, Nelli; Heino, Matti T J; Hynynen, Sini-Tuuli; Laine, Hanna; Araújo-Soares, Vera; Sniehotta, Falko F; Vasankari, Tommi; Sund, Reijo; Haukkala, Ari

2017-03-21

No school-based physical activity (PA) interventions among older adolescents have demonstrated long-term effectiveness, and few of them so far have addressed sedentary behaviour (SB). Based on behavioural theories and evidence, we designed a multi-level intervention to increase PA and decrease SB among vocational school students. This study investigates feasibility and acceptability of two main intervention components and research procedures. We also examine uptake of behaviour change techniques (BCTs) by the participants. Design was an outcome assessor blinded, cluster-randomised controlled trial. Four classes of students (matched pairs) were randomised into one intervention and one control arm. The intervention consisted of (1) a 6-h group-based intervention for students, (2) two 2-h training workshops to reduce their students' sitting in class for teachers, and (3) provision of light PA equipment in classrooms. At baseline (T1), mid-intervention (T2) at 3 weeks, post-intervention (T3) and 6 months after baseline (T4) we measured hypothesised psychosocial mediators and self-reported PA and sitting. Objective assessment of PA and SB (7-day accelerometry) was conducted at T1, T3 and T4. Body composition (bioimpedance) was measured at T1 and T4. Students and teachers in the intervention arm filled in acceptability questionnaires at T3. Recruitment rate was 64% (students) and 88.9% (teachers), and at T3, all post-intervention measurements were completed by 33 students (retention 76.7%) and 15 teachers (retention 93.8%). Acceptability ratings of sessions were high (students M = 6.29, scale 1-7), and data collection procedures were feasible. Intervention arm students reported increased use of BCTs, but uptake of some key BCTs was suboptimal. BCT use correlated highly with objective measures of PA. Based on both self-report and student evaluation, teachers in the intervention arm increased the use of sitting reduction strategies at post-intervention and T4 follow-up (p < .05). We detected willingness of the target groups to participate, good response rates to questionnaires, adequate retention, as well as acceptability of the trial protocol. Investigation of BCT use among students helped further enhance intervention procedures to promote BCT use. After making necessary modifications identified, intervention effectiveness can next be tested in a definitive trial. ISRCTN34534846 . Registered 23 May 2014. Retrospectively registered.

CO2-O2 interactions in extension of tolerance to acute hypoxia

NASA Technical Reports Server (NTRS)

Lambertsen, C. J.

1995-01-01

Objectives and results of experimental projects a re summarized. The scope of information desired included (1) physiological and performance consequences of exposures to simulated microgravity, in rest and graded physical activity, (2) separate influences of graded degrees of atmospheric hypercapnia and hypoxia, and (3) composite effects of hypoxia and hypercapnia. The research objectives were selected for close relevance to existing quantitative information concerning interactions of hypercapnia and hypoxia on respiratory and brain circulatory control. They include: (1) to determine influences of normoxic immersion on interrelations of pulmonary ventilation, arterial PCO2 and PO2, and brain blood flow, in rest and physical work; (2) to determine influence of normoxic immersion on respiratory reactivity to atmospheric hypercapnia at rest; (3) to determine influence of atmospheric hypoxia on respiratory reactivity to hypercapnia at rest and in work; and (4) to provide physiological baselines of data concerning adaptations in acute exposures to aid in investigation of rates of adaptation or deteriorations in physiological or performance capability during subsequent multi-day exposures. A list of publications related to the present grant period is included along with an appendix describing the Performance Measurement System (human perceptual, cognitive and psychomotor functions).

Multi-level biological responses in Ucides cordatus (Linnaeus, 1763) (Brachyura, Ucididae) as indicators of conservation status in mangrove areas from the western atlantic.

PubMed

Duarte, Luis Felipe de Almeida; Souza, Caroline Araújo de; Nobre, Caio Rodrigues; Pereira, Camilo Dias Seabra; Pinheiro, Marcelo Antonio Amaro

2016-11-01

There is a global lack of knowledge on tropical ecotoxicology, particularly in terms of mangrove areas. These areas often serve as nurseries or homes for several animal species, including Ucides cordatus (the uçá crab). This species is widely distributed, is part of the diet of human coastal communities, and is considered to be a sentinel species due to its sensitivity to toxic xenobiotics in natural environments. Sublethal damages to benthic populations reveal pre-pathological conditions, but discussions of the implications are scarce in the literature. In Brazil, the state of São Paulo offers an interesting scenario for ecotoxicology and population studies: it is easy to distinguish between mangroves that are well preserved and those which are significantly impacted by human activity. The objectives of this study were to provide the normal baseline values for the frequency of Micronucleated cells (MN‰) and for neutral red retention time (NRRT) in U. cordatus at pristine locations, as well to indicate the conservation status of different mangrove areas using a multi-level biological response approach in which these biomarkers and population indicators (condition factor and crab density) are applied in relation to environmental quality indicators (determined via information in the literature and solid waste volume). A mangrove area with no effects of impact (areas of reference or pristine areas) presented a mean value of MN‰<3 and NRRT>120min, values which were assumed as baseline values representing genetic and physiological normality. A significant correlation was found between NRRT and MN, with both showing similar and effective results for distinguishing between different mangrove areas according to conservation status. Furthermore, crab density was lower in more impacted mangrove areas, a finding which also reflects the effects of sublethal damage; this finding was not determined by condition factor measurements. Multi-level biological responses were able to reflect the conservation status of the mangrove areas studied using information on guideline values of MN‰, NRRT, and density of the uçá crab in order to categorize three levels of human impacts in mangrove areas: PNI (probable null impact); PLI (probable low impact); and PHI (probable high impact). Results confirm the success of U. cordatus species' multi-level biological responses in diagnosing threats to mangrove areas. Therefore, this species represents an effective tool in studies on mangrove conservation statuses in the Western Atlantic. Copyright © 2016 Elsevier Inc. All rights reserved.

Multi-Objective Optimization of an In situ Bioremediation Technology to Treat Perchlorate-Contaminated Groundwater

EPA Science Inventory

The presentation shows how a multi-objective optimization method is integrated into a transport simulator (MT3D) for estimating parameters and cost of in-situ bioremediation technology to treat perchlorate-contaminated groundwater.

Sleep and its associations with perceived and objective cognitive impairment in individuals with multiple sclerosis.

PubMed

Hughes, Abbey J; Parmenter, Brett A; Haselkorn, Jodie K; Lovera, Jesus F; Bourdette, Dennis; Boudreau, Eilis; Cameron, Michelle H; Turner, Aaron P

2017-08-01

Problems with sleep and cognitive impairment are common among people with multiple sclerosis (MS). The present study examined the relationship between self-reported sleep and both objective and perceived cognitive impairment in MS. Data were obtained from the baseline assessment of a multi-centre intervention trial (NCT00841321). Participants were 121 individuals with MS. Nearly half (49%) of participants met the criteria for objective cognitive impairment; however, cognitively impaired and unimpaired participants did not differ on any self-reported sleep measures. Nearly two-thirds (65%) of participants met the criteria for 'poor' sleep, and poorer sleep was significantly associated with greater levels of perceived cognitive impairment. Moreover, the relationships between self-reported sleep and perceived cognitive impairment were significant beyond the influence of clinical and demographic factors known to influence sleep and cognitive functioning (e.g. age, sex, education level, disability severity, type of MS, disease duration, depression and fatigue). However, self-reported sleep was not associated with any measures of objective cognitive impairment. Among different types of perceived cognitive impairment, poor self-reported sleep was most commonly related to worse perceived executive function (e.g. planning/organization) and prospective memory. Results from the present study emphasize that self-reported sleep is significantly and independently related to perceived cognitive impairment in MS. In terms of clinical implications, interventions focused on improving sleep may help improve perceived cognitive function and quality of life in this population; however, the impact of improved sleep on objective cognitive function requires further investigation. © 2017 European Sleep Research Society.

A Multi-instrument and Multi-wavelength High Angular Resolution Study of MWC 614: Quantum Heated Particles Inside the Disk Cavity

NASA Astrophysics Data System (ADS)

Kluska, Jacques; Kraus, Stefan; Davies, Claire L.; Harries, Tim; Willson, Matthew; Monnier, John D.; Aarnio, Alicia; Baron, Fabien; Millan-Gabet, Rafael; Ten Brummelaar, Theo; Che, Xiao; Hinkley, Sasha; Preibisch, Thomas; Sturmann, Judit; Sturmann, Laszlo; Touhami, Yamina

2018-03-01

High angular resolution observations of young stellar objects are required to study the inner astronomical units of protoplanetary disks in which the majority of planets form. As they evolve, gaps open up in the inner disk regions and the disks are fully dispersed within ∼10 Myr. MWC 614 is a pretransitional object with a ∼10 au radius gap. We present a set of high angular resolution observations of this object including SPHERE/ZIMPOL polarimetric and coronagraphic images in the visible, Keck/NIRC2 near-infrared (NIR) aperture masking observations, and Very Large Telescope Interferometer (AMBER, MIDI, and PIONIER) and Center for High Angular Resolution Astronomy (CLASSIC and CLIMB) long-baseline interferometry at infrared wavelengths. We find that all the observations are compatible with an inclined disk (i ∼ 55° at a position angle of ∼20°–30°). The mid-infrared data set confirms that the disk inner rim is at 12.3 ± 0.4 au from the central star. We determined an upper mass limit of 0.34 M ⊙ for a companion inside the cavity. Within the cavity, the NIR emission, usually associated with the dust sublimation region, is unusually extended (∼10 au, 30 times larger than the theoretical sublimation radius) and indicates a high dust temperature (T ∼ 1800 K). As a possible result of companion-induced dust segregation, quantum heated dust grains could explain the extended NIR emission with this high temperature. Our observations confirm the peculiar state of this object where the inner disk has already been accreted onto the star, exposing small particles inside the cavity to direct stellar radiation. Based on observations made with the Keck observatory (NASA program ID N104N2) and with ESO telescopes at the Paranal Observatory (ESO program IDs 073.C-0720, 077.C-0226, 077.C-0521, 083.C-0984, 087.C-0498(A), 190.C-0963, 095.C-0883) and with the Center for High Angular Resolution Astronomy observatory.

Sleep restriction therapy for insomnia is associated with reduced objective total sleep time, increased daytime somnolence, and objectively impaired vigilance: implications for the clinical management of insomnia disorder.

PubMed

Kyle, Simon D; Miller, Christopher B; Rogers, Zoe; Siriwardena, A Niroshan; Macmahon, Kenneth M; Espie, Colin A

2014-02-01

To investigate whether sleep restriction therapy (SRT) is associated with reduced objective total sleep time (TST), increased daytime somnolence, and impaired vigilance. Within-subject, noncontrolled treatment investigation. Sleep research laboratory. Sixteen patients [10 female, mean age = 47.1 (10.8) y] with well-defined psychophysiological insomnia (PI), reporting TST ≤ 6 h. Patients were treated with single-component SRT over a 4-w protocol, sleeping in the laboratory for 2 nights prior to treatment initiation and for 3 nights (SRT night 1, 8, 22) during the acute interventional phase. The psychomotor vigilance task (PVT) was completed at seven defined time points [day 0 (baseline), day 1,7,8,21,22 (acute treatment) and day 84 (3 mo)]. The Epworth Sleepiness Scale (ESS) was completed at baseline, w 1-4, and 3 mo. Subjective sleep outcomes and global insomnia severity significantly improved before and after SRT. There was, however, a robust decrease in PSG-defined TST during acute implementation of SRT, by an average of 91 min on night 1, 78 min on night 8, and 69 min on night 22, relative to baseline (P < 0.001; effect size range = 1.60-1.80). During SRT, PVT lapses were significantly increased from baseline (at three of five assessment points, all P < 0.05; effect size range = 0.69-0.78), returning to baseline levels by 3 mo (P = 0.43). A similar pattern was observed for RT, with RTs slowing during acute treatment (at four of five assessment points, all P < 0.05; effect size range = 0.57-0.89) and returning to pretreatment levels at 3 mo (P = 0.78). ESS scores were increased at w 1, 2, and 3 (relative to baseline; all P < 0.05); by 3 mo, sleepiness had returned to baseline (normative) levels (P = 0.65). For the first time we show that acute sleep restriction therapy is associated with reduced objective total sleep time, increased daytime sleepiness, and objective performance impairment. Our data have important implications for implementation guidelines around the safe and effective delivery of cognitive behavioral therapy for insomnia.

Chronic disease self-management program for Chinese patients: a preliminary multi-baseline study.

PubMed

Chan, Sam C C; Siu, Andrew M H; Poon, Peter K K; Chan, Chetwyn C H

2005-12-01

This study reports the preliminary findings on the effects of the Chronic Disease Self-management Program on a group of Chinese participants who suffered from chronic diseases. A total of 23 participants were recruited in a multi-baseline study protocol. Their self-management behaviors, self-efficacy and health status were captured over three baseline assessments and one post-test assessment. The results indicated significant increases in the performance of stretching exercises, the management of cognitive symptoms and communication with physicians. Their self-efficacy in terms of these aspects was found to be significantly increased. However, changes in other aspects of self-management which required more special skills and coordination with outside agencies were not significant. The changes in the physical and mental statuses of the participants were also not significant. It was observed that the positive effects of the program could be attributed to traditional Chinese beliefs of 'self-discipline' and a welcoming response towards self-efficacy strategies. Further studies should adhere to standards of a randomized clinical trial and further examine the mechanisms underpinning the changes in self-management behaviors among Chinese people with chronic diseases.

Ideal MHD Stability and Characteristics of Edge Localized Modes on CFETR

NASA Astrophysics Data System (ADS)

Li, Zeyu; Chan, Vincent; Xu, Xueqiao; Wang, Xiaogang; Cfetr Physics Team

2017-10-01

Investigation on the equilibrium operation regime, its ideal magnetohydrodynamics (MHD) stability and edge localized modes (ELM) characteristics is performed for China Fusion Engineering Test Reactor (CFETR). The CFETR operation regime study starts with a baseline scenario derived from multi-code integrated modeling, with key parameters varied to build a systematic database. These parameters, under profile and pedestal constraints, provide the foundation for engineering design. The linear stabilities of low-n and intermediate-n peeling-ballooning modes for CFETR baseline scenario are analyzed. Multi-code benchmarking, including GATO, ELITE, BOUT + + and NIMROD, demonstrated good agreement in predicting instabilities. Nonlinear behavior of ELMs for the baseline scenario is simulated using BOUT + + . Instabilities are found both at the pedestal top and inside the pedestal region, which lead to a mix of grassy and type I ELMs. Pedestal structures extending inward beyond the pedestal top are also varied to study the influence on ELM characteristic. Preliminary results on the dependence of the Type-I ELM divertor heat load scaling on machine size and pedestal pressure will also be presented. Prepared by LLNL under Contract DE-AC52-07NA27344 and National Magnetic Confinement Fusion Research Program of China (Grant No. 2014GB110003 and 2014GB107004).

Multi-objective optimization to evaluate tradeoffs among forest ecosystem services following fire hazard reduction in the Deschutes National Forest, USA

Treesearch

Svetlana A. (Kushch) Schroder; Sandor F. Toth; Robert L. Deal; Gregory J. Ettl

2016-01-01

Forest owners worldwide are increasingly interested in managing forests to provide a broad suite of Ecosystem services, balancing multiple objectives and evaluating management activities in terms of Potential tradeoffs. We describe a multi-objective mathematical programming model to quantify tradeoffs in expected sediment delivery and the preservation of Northern...

HESS J1943+213: A Non-classical High-frequency-peaked BL Lac Object

NASA Astrophysics Data System (ADS)

Straal, S. M.; Gabányi, K. É.; van Leeuwen, J.; Clarke, T. E.; Dubner, G.; Frey, S.; Giacani, E.; Paragi, Z.

2016-05-01

HESS J1943+213 is an unidentified TeV source that is likely a high-frequency-peaked BL Lac (HBL) object, but that is also compatible with a pulsar wind nebula (PWN) nature. Each of these enormously different astronomical interpretations is supported by some of the observed unusual characteristics. In order to finally classify and understand this object, we took a three-pronged approach, through time-domain, high angular resolution, and multi-frequency radio studies. First, our deep time-domain observations with the Arecibo telescope failed to uncover the putative pulsar powering the proposed PWN. We conclude with ˜70% certainty that HESS J1943+213 does not host a pulsar. Second, long-baseline interferometry of the source with e-MERLIN at 1.5 and 5 GHz shows only a core, that is, a point source at ˜ 1-100 mas resolution. Its 2013 flux density is about one-third lower than that detected in the 2011 observations with similar resolution. This radio variability of the core strengthens the HBL object hypothesis. Third, additional evidence against the PWN scenario comes from the radio spectrum we compiled. The extended structure follows a power-law behavior with spectral index α \\=\\-0.54+/- 0.04 while the core component displays a flat spectrum (α \\=\\-0.03+/- 0.03). In contrast, the radio synchrotron emission of PWNe predicts a single power-law distribution. Overall, we rule out the PWN hypothesis and conclude that the source is a BL Lac object. The consistently high fraction (70%) of the flux density from the extended structure then leads us to conclude that HESS J1943+213 must be a non-classical HBL object.

Modeling and optimization of the multiobjective stochastic joint replenishment and delivery problem under supply chain environment.

PubMed

Wang, Lin; Qu, Hui; Liu, Shan; Dun, Cai-xia

2013-01-01

As a practical inventory and transportation problem, it is important to synthesize several objectives for the joint replenishment and delivery (JRD) decision. In this paper, a new multiobjective stochastic JRD (MSJRD) of the one-warehouse and n-retailer systems considering the balance of service level and total cost simultaneously is proposed. The goal of this problem is to decide the reasonable replenishment interval, safety stock factor, and traveling routing. Secondly, two approaches are designed to handle this complex multi-objective optimization problem. Linear programming (LP) approach converts the multi-objective to single objective, while a multi-objective evolution algorithm (MOEA) solves a multi-objective problem directly. Thirdly, three intelligent optimization algorithms, differential evolution algorithm (DE), hybrid DE (HDE), and genetic algorithm (GA), are utilized in LP-based and MOEA-based approaches. Results of the MSJRD with LP-based and MOEA-based approaches are compared by a contrastive numerical example. To analyses the nondominated solution of MOEA, a metric is also used to measure the distribution of the last generation solution. Results show that HDE outperforms DE and GA whenever LP or MOEA is adopted.

Modeling and Optimization of the Multiobjective Stochastic Joint Replenishment and Delivery Problem under Supply Chain Environment

PubMed Central

Dun, Cai-xia

2013-01-01

As a practical inventory and transportation problem, it is important to synthesize several objectives for the joint replenishment and delivery (JRD) decision. In this paper, a new multiobjective stochastic JRD (MSJRD) of the one-warehouse and n-retailer systems considering the balance of service level and total cost simultaneously is proposed. The goal of this problem is to decide the reasonable replenishment interval, safety stock factor, and traveling routing. Secondly, two approaches are designed to handle this complex multi-objective optimization problem. Linear programming (LP) approach converts the multi-objective to single objective, while a multi-objective evolution algorithm (MOEA) solves a multi-objective problem directly. Thirdly, three intelligent optimization algorithms, differential evolution algorithm (DE), hybrid DE (HDE), and genetic algorithm (GA), are utilized in LP-based and MOEA-based approaches. Results of the MSJRD with LP-based and MOEA-based approaches are compared by a contrastive numerical example. To analyses the nondominated solution of MOEA, a metric is also used to measure the distribution of the last generation solution. Results show that HDE outperforms DE and GA whenever LP or MOEA is adopted. PMID:24302880

Beam-dynamics driven design of the LHeC energy-recovery linac

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pellegrini, Dario; Latina, Andrea; Schulte, Daniel

The LHeC study is a possible upgrade of the LHC that aims at delivering an electron beam for collisions with the existing hadronic beams. The current baseline design for the electron facility consists of a multi-pass superconducting energy-recovery linac operating in a continuous wave mode. Here, we summarize the overall layout of such ERL complex located on the LHC site and introduce the most recent developments. We review of the lattice components, presenting their baseline design along with possible alternatives that aims at improving the overall machine performance. The detector bypass has been designed and integrated into the lattice. Trackingmore » simulations allowed us to verify the high current (~150 mA in the linacs) beam operation required for the LHeC to serve as an Higgs Factory. The impact of single and multi-bunch wake-fields, synchrotron radiation and beam-beam effects has been assessed in this paper.« less

Beam-dynamics driven design of the LHeC energy-recovery linac

DOE PAGES

Pellegrini, Dario; Latina, Andrea; Schulte, Daniel; ...

2015-12-23

The LHeC study is a possible upgrade of the LHC that aims at delivering an electron beam for collisions with the existing hadronic beams. The current baseline design for the electron facility consists of a multi-pass superconducting energy-recovery linac operating in a continuous wave mode. Here, we summarize the overall layout of such ERL complex located on the LHC site and introduce the most recent developments. We review of the lattice components, presenting their baseline design along with possible alternatives that aims at improving the overall machine performance. The detector bypass has been designed and integrated into the lattice. Trackingmore » simulations allowed us to verify the high current (~150 mA in the linacs) beam operation required for the LHeC to serve as an Higgs Factory. The impact of single and multi-bunch wake-fields, synchrotron radiation and beam-beam effects has been assessed in this paper.« less

Directly driven source of multi-gigahertz, sub-picosecond optical pulses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Messerly, Michael J.; Dawson, Jay W.; Barty, Christopher P.J.

2015-10-20

A robust, compact optical pulse train source is described, with the capability of generating sub-picosecond micro-pulse sequences, which can be periodic as well as non-periodic, and at repetition rates tunable over decades of baseline frequencies, from MHz to multi-GHz regimes. The micro-pulses can be precisely controlled and formatted to be in the range of many ps in duration to as short as several fs in duration. The system output can be comprised of a continuous wave train of optical micro-pulses or can be programmed to provide gated bursts of macro-pulses, with each macro-pulse consisting of a specific number of micro-pulsesmore » or a single pulse picked from the higher frequency train at a repetition rate lower than the baseline frequency. These pulses could then be amplified in energy anywhere from the nJ to MJ range.« less

The study of key issues about integration of GNSS and strong-motion records for real-time earthquake monitoring

NASA Astrophysics Data System (ADS)

Tu, Rui; Zhang, Pengfei; Zhang, Rui; Liu, Jinhai

2016-08-01

This paper has studied the key issues about integration of GNSS and strong-motion records for real-time earthquake monitoring. The validations show that the consistence of the coordinate system must be considered firstly to exclude the system bias between GNSS and strong-motion. The GNSS sampling rate is suggested about 1-5 Hz, and we should give the strong-motion's baseline shift with a larger dynamic noise as its variation is very swift. The initialization time of solving the baseline shift is less than one minute, and ambiguity resolution strategy is not greatly improved the solution. The data quality is very important for the solution, we advised to use multi-frequency and multi-system observations. These ideas give an important guide for real-time earthquake monitoring and early warning by the tight integration of GNSS and strong-motion records.

Negotiating designs of multi-purpose reservoir systems in international basins

NASA Astrophysics Data System (ADS)

Geressu, Robel; Harou, Julien

2016-04-01

Given increasing agricultural and energy demands, coordinated management of multi-reservoir systems could help increase production without further stressing available water resources. However, regional or international disputes about water-use rights pose a challenge to efficient expansion and management of many large reservoir systems. Even when projects are likely to benefit all stakeholders, agreeing on the design, operation, financing, and benefit sharing can be challenging. This is due to the difficulty of considering multiple stakeholder interests in the design of projects and understanding the benefit trade-offs that designs imply. Incommensurate performance metrics, incomplete knowledge on system requirements, lack of objectivity in managing conflict and difficulty to communicate complex issue exacerbate the problem. This work proposes a multi-step hybrid multi-objective optimization and multi-criteria ranking approach for supporting negotiation in water resource systems. The approach uses many-objective optimization to generate alternative efficient designs and reveal the trade-offs between conflicting objectives. This enables informed elicitation of criteria weights for further multi-criteria ranking of alternatives. An ideal design would be ranked as best by all stakeholders. Resource-sharing mechanisms such as power-trade and/or cost sharing may help competing stakeholders arrive at designs acceptable to all. Many-objective optimization helps suggests efficient designs (reservoir site, its storage size and operating rule) and coordination levels considering the perspectives of multiple stakeholders simultaneously. We apply the proposed approach to a proof-of-concept study of the expansion of the Blue Nile transboundary reservoir system.

Improving Ambiguity Resolution for Medium Baselines Using Combined GPS and BDS Dual/Triple-Frequency Observations.

PubMed

Gao, Wang; Gao, Chengfa; Pan, Shuguo; Wang, Denghui; Deng, Jiadong

2015-10-30

The regional constellation of the BeiDou navigation satellite system (BDS) has been providing continuous positioning, navigation and timing services since 27 December 2012, covering China and the surrounding area. Real-time kinematic (RTK) positioning with combined BDS and GPS observations is feasible. Besides, all satellites of BDS can transmit triple-frequency signals. Using the advantages of multi-pseudorange and carrier observations from multi-systems and multi-frequencies is expected to be of much benefit for ambiguity resolution (AR). We propose an integrated AR strategy for medium baselines by using the combined GPS and BDS dual/triple-frequency observations. In the method, firstly the extra-wide-lane (EWL) ambiguities of triple-frequency system, i.e., BDS, are determined first. Then the dual-frequency WL ambiguities of BDS and GPS were resolved with the geometry-based model by using the BDS ambiguity-fixed EWL observations. After that, basic (i.e., L1/L2 or B1/B2) ambiguities of BDS and GPS are estimated together with the so-called ionosphere-constrained model, where the ambiguity-fixed WL observations are added to enhance the model strength. During both of the WL and basic AR, a partial ambiguity fixing (PAF) strategy is adopted to weaken the negative influence of new-rising or low-elevation satellites. Experiments were conducted and presented, in which the GPS/BDS dual/triple-frequency data were collected in Nanjing and Zhengzhou of China, with the baseline distance varying from about 28.6 to 51.9 km. The results indicate that, compared to the single triple-frequency BDS system, the combined system can significantly enhance the AR model strength, and thus improve AR performance for medium baselines with a 75.7% reduction of initialization time on average. Besides, more accurate and stable positioning results can also be derived by using the combined GPS/BDS system.

Improving Ambiguity Resolution for Medium Baselines Using Combined GPS and BDS Dual/Triple-Frequency Observations

PubMed Central

Gao, Wang; Gao, Chengfa; Pan, Shuguo; Wang, Denghui; Deng, Jiadong

2015-01-01

The regional constellation of the BeiDou navigation satellite system (BDS) has been providing continuous positioning, navigation and timing services since 27 December 2012, covering China and the surrounding area. Real-time kinematic (RTK) positioning with combined BDS and GPS observations is feasible. Besides, all satellites of BDS can transmit triple-frequency signals. Using the advantages of multi-pseudorange and carrier observations from multi-systems and multi-frequencies is expected to be of much benefit for ambiguity resolution (AR). We propose an integrated AR strategy for medium baselines by using the combined GPS and BDS dual/triple-frequency observations. In the method, firstly the extra-wide-lane (EWL) ambiguities of triple-frequency system, i.e., BDS, are determined first. Then the dual-frequency WL ambiguities of BDS and GPS were resolved with the geometry-based model by using the BDS ambiguity-fixed EWL observations. After that, basic (i.e., L1/L2 or B1/B2) ambiguities of BDS and GPS are estimated together with the so-called ionosphere-constrained model, where the ambiguity-fixed WL observations are added to enhance the model strength. During both of the WL and basic AR, a partial ambiguity fixing (PAF) strategy is adopted to weaken the negative influence of new-rising or low-elevation satellites. Experiments were conducted and presented, in which the GPS/BDS dual/triple-frequency data were collected in Nanjing and Zhengzhou of China, with the baseline distance varying from about 28.6 to 51.9 km. The results indicate that, compared to the single triple-frequency BDS system, the combined system can significantly enhance the AR model strength, and thus improve AR performance for medium baselines with a 75.7% reduction of initialization time on average. Besides, more accurate and stable positioning results can also be derived by using the combined GPS/BDS system. PMID:26528977

A multi-objective optimization model for hub network design under uncertainty: An inexact rough-interval fuzzy approach

NASA Astrophysics Data System (ADS)

Niakan, F.; Vahdani, B.; Mohammadi, M.

2015-12-01

This article proposes a multi-objective mixed-integer model to optimize the location of hubs within a hub network design problem under uncertainty. The considered objectives include minimizing the maximum accumulated travel time, minimizing the total costs including transportation, fuel consumption and greenhouse emissions costs, and finally maximizing the minimum service reliability. In the proposed model, it is assumed that for connecting two nodes, there are several types of arc in which their capacity, transportation mode, travel time, and transportation and construction costs are different. Moreover, in this model, determining the capacity of the hubs is part of the decision-making procedure and balancing requirements are imposed on the network. To solve the model, a hybrid solution approach is utilized based on inexact programming, interval-valued fuzzy programming and rough interval programming. Furthermore, a hybrid multi-objective metaheuristic algorithm, namely multi-objective invasive weed optimization (MOIWO), is developed for the given problem. Finally, various computational experiments are carried out to assess the proposed model and solution approaches.

Application of Multi-Objective Human Learning Optimization Method to Solve AC/DC Multi-Objective Optimal Power Flow Problem

NASA Astrophysics Data System (ADS)

Cao, Jia; Yan, Zheng; He, Guangyu

2016-06-01

This paper introduces an efficient algorithm, multi-objective human learning optimization method (MOHLO), to solve AC/DC multi-objective optimal power flow problem (MOPF). Firstly, the model of AC/DC MOPF including wind farms is constructed, where includes three objective functions, operating cost, power loss, and pollutant emission. Combining the non-dominated sorting technique and the crowding distance index, the MOHLO method can be derived, which involves individual learning operator, social learning operator, random exploration learning operator and adaptive strategies. Both the proposed MOHLO method and non-dominated sorting genetic algorithm II (NSGAII) are tested on an improved IEEE 30-bus AC/DC hybrid system. Simulation results show that MOHLO method has excellent search efficiency and the powerful ability of searching optimal. Above all, MOHLO method can obtain more complete pareto front than that by NSGAII method. However, how to choose the optimal solution from pareto front depends mainly on the decision makers who stand from the economic point of view or from the energy saving and emission reduction point of view.

Multi-objective based spectral unmixing for hyperspectral images

NASA Astrophysics Data System (ADS)

Xu, Xia; Shi, Zhenwei

2017-02-01

Sparse hyperspectral unmixing assumes that each observed pixel can be expressed by a linear combination of several pure spectra in a priori library. Sparse unmixing is challenging, since it is usually transformed to a NP-hard l0 norm based optimization problem. Existing methods usually utilize a relaxation to the original l0 norm. However, the relaxation may bring in sensitive weighted parameters and additional calculation error. In this paper, we propose a novel multi-objective based algorithm to solve the sparse unmixing problem without any relaxation. We transform sparse unmixing to a multi-objective optimization problem, which contains two correlative objectives: minimizing the reconstruction error and controlling the endmember sparsity. To improve the efficiency of multi-objective optimization, a population-based randomly flipping strategy is designed. Moreover, we theoretically prove that the proposed method is able to recover a guaranteed approximate solution from the spectral library within limited iterations. The proposed method can directly deal with l0 norm via binary coding for the spectral signatures in the library. Experiments on both synthetic and real hyperspectral datasets demonstrate the effectiveness of the proposed method.

VizieR Online Data Catalog: The VLBA Extragalactic Proper Motion Catalog (Truebenbach+, 2017)

NASA Astrophysics Data System (ADS)

Truebenbach, A. E.; Darling, J.

2017-11-01

We created our catalog of extragalactic radio proper motions using the 2017a Goddard VLBI global solution. The 2017a solution is computed from more than 30 years of dual-band VLBI observations --1979 August 3 to 2017 March 27. We also observed 28 objects with either no redshift or a "questionable" Optical Characteristic of Astrometric Radio Sources (OCARS; Malkin 2016ARep...60..996M) redshift at the Apache Point Observatory (APO) 3.5m telescope and/or at Gemini North. We conducted observations on the 3.5m telescope at Apache Point Observatory with the Dual Imaging Spectrograph (DIS) from 2015 April 18 to 2016 June 30. We chose two objects for additional observations with the Gemini Multi-Object Spectrograph-North (GMOS-N) at Gemini North Observatory. 2021+317 was observed on 2016 June 26 and 28, while 0420+417 was observed on 2016 November 8 and 26. We also observed 42 radio sources with the Very Long Baseline Array (VLBA) in the X-band (3.6cm/8.3GHz). Our targets had all been previously observed by VLBI. Our VLBA observations were conducted in two campaigns from 2015 September to 2016 January and 2016 October to November. The final extragalactic proper motion catalog (created primarily from archival Goddard VLBI data, with redshifts obtained from OCARS) contains 713 proper motions with average uncertainties of 24μas/yr. (5 data files).

Chemotherapy Use, Performance Status, and Quality of Life at the End of Life

PubMed Central

Prigerson, Holly G.; Bao, Yuhua; Shah, Manish A.; Paulk, M. Elizabeth; LeBlanc, Thomas W.; Schneider, Bryan J.; Garrido, Melissa M.; Reid, M. Carrington; Berlin, David A.; Adelson, Kerin B.; Neugut, Alfred I.; Maciejewski, Paul K.

2016-01-01

IMPORTANCE Although many patients with end-stage cancer are offered chemotherapy to improve quality of life (QOL), the association between chemotherapy and QOL amid progressive metastatic disease has not been well-studied. American Society for Clinical Oncology guidelines recommend palliative chemotherapy only for solid tumor patients with good performance status. OBJECTIVE To evaluate the association between chemotherapy use and QOL near death (QOD) as a function of patients’ performance status. DESIGN, SETTING, AND PARTICIPANTS A multi-institutional, longitudinal cohort study of patients with end-stage cancer recruited between September 2002 and February 2008. Chemotherapy use (n = 158 [50.6%]) and Eastern Cooperative Oncology Group (ECOG) performance status were assessed at baseline (median = 3.8 months before death) and patients with progressive metastatic cancer (N = 312) following at least 1 chemotherapy regimen were followed prospectively until death at 6 outpatient oncology clinics in the United States. MAIN OUTCOMES AND MEASURES Patient QOD was determined using validated caregiver ratings of patients’ physical and mental distress in their final week. RESULTS Chemotherapy use was not associated with patient survival controlling for clinical setting and patients’ performance status. Among patients with good (ECOG score = 1) baseline performance status, chemotherapy use compared with nonuse was associated with worse QOD (odds ratio [OR], 0.35; 95% CI, 0.17-0.75; P = .01). Baseline chemotherapy use was not associated with QOD among patients with moderate (ECOG score = 2) baseline performance status (OR, 1.06; 95% CI, 0.51-2.21; P = .87) or poor (ECOG score = 3) baseline performance status (OR, 1.34; 95% CI, 0.46-3.89; P = .59). CONCLUSIONS AND RELEVANCE Although palliative chemotherapy is used to improve QOL for patients with end-stage cancer, its use did not improve QOD for patients with moderate or poor performance status and worsened QOD for patients with good performance status. The QOD in patients with end-stage cancer is not improved, and can be harmed, by chemotherapy use near death, even in patients with good performance status. PMID:26203912

Coronary artery calcium before and after hospitalization with pneumonia: The MESA study.

PubMed

Corrales-Medina, Vicente F; Dwivedi, Girish; Taljaard, Monica; Petrcich, William; Lima, Joao A; Yende, Sachin; Kronmal, Richard A; Chirinos, Julio A

2018-01-01

Epidemiological analyses demonstrate that pneumonia survivors have a higher risk of myocardial infarction than people with similar load of risk factors for atherosclerotic cardiovascular disease (ASCVD) but without pneumonia. This may be due to a higher baseline burden of ASCVD in patients with pneumonia that is not captured by the accounting of known ASCVD risk factors in epidemiological analyses or to unfavorable accelerating effects of pneumonia on atherosclerosis. We analyzed data from the Multi-Ethnic Study of Atherosclerosis. We identified 54 participants that were hospitalized for pneumonia during study follow-up and that also had assessment of coronary artery calcium (CAC, an objective marker of coronary atherosclerotic burden) before and after this hospitalization. We matched them to 54 participants who were not hospitalized for pneumonia but that had CAC assessments at the same study visits as the pneumonia cases. We compared baseline CAC scores and their progression between groups. Baseline CAC scores were similar in both groups (median [IQR]; 6.3 [0-356.8] in pneumonia participants vs. 10.8 [0-178.3] in controls; p = 0.25). After a median of 4.8 years, the direction and magnitude of CAC score change, and the slope of CAC score progression between groups was also similar (median change [IQR], 21.8 [0 to 287.29] in participants with pneumonia versus 15.8 [0 to 140.94] in controls, p = 0.28; difference in slope, 7.7, 95% CI -9.0 to 24.6, p = 0.18). However, among participants with high baseline ASCVD risk (i.e. ACC/AHA 10-year risk estimate ≥7.5%), participants with pneumonia showed a larger increase in CAC scores (median change [IQR]; 159.10 [38.55-407.34] versus 48.72 [0.97-246.99] in controls; p = 0.02) and a trend towards a steeper slope of CAC score progression (difference in slope, 19.7, 95% CI -6.6 to 45.6, p = 0.07). Pneumonia may accelerate the progression of atherosclerosis in people with high baseline ASCVD risk.

Improved Modeling of Finite-Rate Turbulent Combustion Processes in Research Combustors

NASA Technical Reports Server (NTRS)

VanOverbeke, Thomas J.

1998-01-01

The objective of this thesis is to further develop and test a stochastic model of turbulent combustion in recirculating flows. There is a requirement to increase the accuracy of multi-dimensional combustion predictions. As turbulence affects reaction rates, this interaction must be more accurately evaluated. In this work a more physically correct way of handling the interaction of turbulence on combustion is further developed and tested. As turbulence involves randomness, stochastic modeling is used. Averaged values such as temperature and species concentration are found by integrating the probability density function (pdf) over the range of the scalar. The model in this work does not assume the pdf type, but solves for the evolution of the pdf using the Monte Carlo solution technique. The model is further developed by including a more robust reaction solver, by using accurate thermodynamics and by more accurate transport elements. The stochastic method is used with Semi-Implicit Method for Pressure-Linked Equations. The SIMPLE method is used to solve for velocity, pressure, turbulent kinetic energy and dissipation. The pdf solver solves for temperature and species concentration. Thus, the method is partially familiar to combustor engineers. The method is compared to benchmark experimental data and baseline calculations. The baseline method was tested on isothermal flows, evaporating sprays and combusting sprays. Pdf and baseline predictions were performed for three diffusion flames and one premixed flame. The pdf method predicted lower combustion rates than the baseline method in agreement with the data, except for the premixed flame. The baseline and stochastic predictions bounded the experimental data for the premixed flame. The use of a continuous mixing model or relax to mean mixing model had little effect on the prediction of average temperature. Two grids were used in a hydrogen diffusion flame simulation. Grid density did not effect the predictions except for peak temperature and tangential velocity. The hybrid pdf method did take longer and required more memory, but has a theoretical basis to extend to many reaction steps which cannot be said of current turbulent combustion models.

Predictors of change differ for moderate and vigorous intensity physical activity and for weekdays and weekends: a longitudinal analysis

PubMed Central

2013-01-01

Background Predictors of physical activity (PA) change are rarely investigated separately for different PA intensities and for weekdays/weekends. We investigated whether individual-level predictors of one-year change in objectively-measured physical activity differ for moderate PA (MPA) and vigorous PA (VPA) and for weekends and weekdays. Methods Accelerometer-assessed PA (mins) was obtained at baseline and +1 year (n = 875, 41.5% male, Mean ± SD baseline age: 9.8 ± 0.4 years-old). Potential predictors (n = 38) were assessed at baseline from psychological (e.g. self-efficacy), socio-cultural (e.g. parent support) and environmental domains (e.g. land use). Associations between predictors and change in MPA (2000–3999 counts/minute (cpm)) and VPA (≥4000 cpm) separately for weekdays and weekends were studied using multi-level linear regression. Analyses were adjusted for school clustering, sex and baseline PA. Results Weekend PA declined (MPA decline 4.6 ± 21.8 mins/day; VPA decline: 2.1 ± 20.1 mins/day; both p < 0.001) whereas weekday PA did not significantly change. Higher baseline PA and being a girl were associated with greater PA declines in all four outcomes; remaining predictors differed for MPA and VPA and/or weekdays and weekends. Family logistic support was associated with less of a decline in weekend MPA (CI 95%) 0.15 (0.05, 0.25) and VPA 0.19 (0.09, 0.29), and peer support with less of a decline in weekday MPA 0.18 (0.02, 0.34) and VPA 0.22 (0.06, 0.38). Conclusions Results highlight the relevance of investigating predictors of PA change separately for different PA intensities and for weekdays/weekends. In addition to continued focus on school PA promotion, more effort to target interventions during weekends, such as in the family and community appears important. Encouraging peer support to increase weekday PA and targeting parent support for weekend PA may be health promotion priorities. PMID:23714688

Coupled Low-thrust Trajectory and System Optimization via Multi-Objective Hybrid Optimal Control

NASA Technical Reports Server (NTRS)

Vavrina, Matthew A.; Englander, Jacob Aldo; Ghosh, Alexander R.

2015-01-01

The optimization of low-thrust trajectories is tightly coupled with the spacecraft hardware. Trading trajectory characteristics with system parameters ton identify viable solutions and determine mission sensitivities across discrete hardware configurations is labor intensive. Local independent optimization runs can sample the design space, but a global exploration that resolves the relationships between the system variables across multiple objectives enables a full mapping of the optimal solution space. A multi-objective, hybrid optimal control algorithm is formulated using a multi-objective genetic algorithm as an outer loop systems optimizer around a global trajectory optimizer. The coupled problem is solved simultaneously to generate Pareto-optimal solutions in a single execution. The automated approach is demonstrated on two boulder return missions.

Characterization of a Low-Cost Multi-Parameter Sensor for Resource Applications: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Habte, Aron M; Sengupta, Manajit; Andreas, Afshin M

Low-cost multi-parameter sensing and measurement devices enable cost-effective monitoring of the functional, operational reliability, efficiency, and resiliency of the electrical grid. The National Renewable Research Laboratory (NREL) Solar Radiation Research Laboratory (SRRL), in collaboration with Arable Labs Inc., deployed Arable Lab's Mark multi-parameter sensor system. The unique suite of system sensors measures the down-welling and upwelling shortwave solar resource and longwave radiation, humidity, air temperature, and ground temperature. This study describes the shortwave calibration, characteriza-tion, and validation of measurement accuracy of this instrument by comparison with existing instruments that are part of NREL-SRRL's Baseline Measurement System.

A Bayesian alternative for multi-objective ecohydrological model specification

NASA Astrophysics Data System (ADS)

Tang, Yating; Marshall, Lucy; Sharma, Ashish; Ajami, Hoori

2018-01-01

Recent studies have identified the importance of vegetation processes in terrestrial hydrologic systems. Process-based ecohydrological models combine hydrological, physical, biochemical and ecological processes of the catchments, and as such are generally more complex and parametric than conceptual hydrological models. Thus, appropriate calibration objectives and model uncertainty analysis are essential for ecohydrological modeling. In recent years, Bayesian inference has become one of the most popular tools for quantifying the uncertainties in hydrological modeling with the development of Markov chain Monte Carlo (MCMC) techniques. The Bayesian approach offers an appealing alternative to traditional multi-objective hydrologic model calibrations by defining proper prior distributions that can be considered analogous to the ad-hoc weighting often prescribed in multi-objective calibration. Our study aims to develop appropriate prior distributions and likelihood functions that minimize the model uncertainties and bias within a Bayesian ecohydrological modeling framework based on a traditional Pareto-based model calibration technique. In our study, a Pareto-based multi-objective optimization and a formal Bayesian framework are implemented in a conceptual ecohydrological model that combines a hydrological model (HYMOD) and a modified Bucket Grassland Model (BGM). Simulations focused on one objective (streamflow/LAI) and multiple objectives (streamflow and LAI) with different emphasis defined via the prior distribution of the model error parameters. Results show more reliable outputs for both predicted streamflow and LAI using Bayesian multi-objective calibration with specified prior distributions for error parameters based on results from the Pareto front in the ecohydrological modeling. The methodology implemented here provides insight into the usefulness of multiobjective Bayesian calibration for ecohydrologic systems and the importance of appropriate prior distributions in such approaches.