Sample records for observed considerable differences

  1. Cultural Differences in Opportunity Cost Consideration

    PubMed Central

    Zhang, Ning; Ji, Li-Jun; Li, Ye

    2017-01-01

    Two studies were conducted to investigate cultural differences in opportunity cost consideration between Chinese and Euro-Canadians. Opportunity cost is defined as the cost of a benefit that must be forgone in order to pursue a better alternative (Becker et al., 1974). In both studies, participants read about hypothetical purchase scenarios, and then decided whether they would buy a certain product. Opportunity cost consideration was measured in two ways: (1) participants' thoughts pertaining to other (nonfocal) products while making decisions; (2) participants' decisions not to buy a focal product (Study 1) or a more expensive product (Study 2). Across both indexes, we found that after controlling for individual difference variables and amount of pocket money, Chinese participants in China considered financial opportunity cost more than Euro-Canadians in Study 1. Similar results were observed in Study 2 when comparing Chinese in Canada with Euro-Canadians However, the cultural effect on opportunity cost consideration was confounded by family income in Study 2. Implications for resource management, limitations of the current research and directions for future research are discussed. PMID:28184202

  2. Cultural Differences in Opportunity Cost Consideration.

    PubMed

    Zhang, Ning; Ji, Li-Jun; Li, Ye

    2017-01-01

    Two studies were conducted to investigate cultural differences in opportunity cost consideration between Chinese and Euro-Canadians. Opportunity cost is defined as the cost of a benefit that must be forgone in order to pursue a better alternative (Becker et al., 1974). In both studies, participants read about hypothetical purchase scenarios, and then decided whether they would buy a certain product. Opportunity cost consideration was measured in two ways: (1) participants' thoughts pertaining to other (nonfocal) products while making decisions; (2) participants' decisions not to buy a focal product (Study 1) or a more expensive product (Study 2). Across both indexes, we found that after controlling for individual difference variables and amount of pocket money, Chinese participants in China considered financial opportunity cost more than Euro-Canadians in Study 1. Similar results were observed in Study 2 when comparing Chinese in Canada with Euro-Canadians However, the cultural effect on opportunity cost consideration was confounded by family income in Study 2. Implications for resource management, limitations of the current research and directions for future research are discussed.

  3. Design considerations and strategies for lunar-based observations

    NASA Technical Reports Server (NTRS)

    Snoddy, William C.; Nein, Max E.; Hilchey, John D.

    1994-01-01

    This paper addresses the design considerations and strategies for astrophysical observations as key elements of an international solar system exploration program. Emphasis is placed on the technical and programmatic challenges and opportunities associated with an evolving program of lunar-based astronomy. Both robotic and human tended facilities are discussed ranging from relatively small meter-class transit telescopes to large interferometer and filled-aperture systems.

  4. Considerations for Observational Research using Large Datasets in Radiation Oncology

    PubMed Central

    Jagsi, Reshma; Bekelman, Justin E.; Chen, Aileen; Chen, Ronald C.; Hoffman, Karen; Shih, Ya-Chen Tina; Smith, Benjamin D.; Yu, James B.

    2014-01-01

    The radiation oncology community has witnessed growing interest in observational research conducted using large-scale data sources such as registries and claims-based datasets. With the growing emphasis on observational analyses in health care, the radiation oncology community must possess a sophisticated understanding of the methodological considerations of such studies in order to evaluate evidence appropriately to guide practice and policy. Because observational research has unique features that distinguish it from clinical trials and other forms of traditional radiation oncology research, the Red Journal assembled a panel of experts in health services research to provide a concise and well-referenced review, intended to be informative for the lay reader, as well as for scholars who wish to embark on such research without prior experience. This review begins by discussing the types of research questions relevant to radiation oncology that large-scale databases may help illuminate. It then describes major potential data sources for such endeavors, including information regarding access and insights regarding the strengths and limitations of each. Finally, it provides guidance regarding the analytic challenges that observational studies must confront, along with discussion of the techniques that have been developed to help minimize the impact of certain common analytical issues in observational analysis. Features characterizing a well-designed observational study include clearly defined research questions, careful selection of an appropriate data source, consultation with investigators with relevant methodological expertise, inclusion of sensitivity analyses, caution not to overinterpret small but significant differences, and recognition of limitations when trying to evaluate causality. This review concludes that carefully designed and executed studies using observational data that possess these qualities hold substantial promise for advancing our understanding of

  5. Considerations for Observational Research Using Large Data Sets in Radiation Oncology

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jagsi, Reshma, E-mail: rjagsi@med.umich.edu; Bekelman, Justin E.; Chen, Aileen

    The radiation oncology community has witnessed growing interest in observational research conducted using large-scale data sources such as registries and claims-based data sets. With the growing emphasis on observational analyses in health care, the radiation oncology community must possess a sophisticated understanding of the methodological considerations of such studies in order to evaluate evidence appropriately to guide practice and policy. Because observational research has unique features that distinguish it from clinical trials and other forms of traditional radiation oncology research, the International Journal of Radiation Oncology, Biology, Physics assembled a panel of experts in health services research to provide a concisemore » and well-referenced review, intended to be informative for the lay reader, as well as for scholars who wish to embark on such research without prior experience. This review begins by discussing the types of research questions relevant to radiation oncology that large-scale databases may help illuminate. It then describes major potential data sources for such endeavors, including information regarding access and insights regarding the strengths and limitations of each. Finally, it provides guidance regarding the analytical challenges that observational studies must confront, along with discussion of the techniques that have been developed to help minimize the impact of certain common analytical issues in observational analysis. Features characterizing a well-designed observational study include clearly defined research questions, careful selection of an appropriate data source, consultation with investigators with relevant methodological expertise, inclusion of sensitivity analyses, caution not to overinterpret small but significant differences, and recognition of limitations when trying to evaluate causality. This review concludes that carefully designed and executed studies using observational data that possess these

  6. Considerations for observational research using large data sets in radiation oncology.

    PubMed

    Jagsi, Reshma; Bekelman, Justin E; Chen, Aileen; Chen, Ronald C; Hoffman, Karen; Shih, Ya-Chen Tina; Smith, Benjamin D; Yu, James B

    2014-09-01

    The radiation oncology community has witnessed growing interest in observational research conducted using large-scale data sources such as registries and claims-based data sets. With the growing emphasis on observational analyses in health care, the radiation oncology community must possess a sophisticated understanding of the methodological considerations of such studies in order to evaluate evidence appropriately to guide practice and policy. Because observational research has unique features that distinguish it from clinical trials and other forms of traditional radiation oncology research, the International Journal of Radiation Oncology, Biology, Physics assembled a panel of experts in health services research to provide a concise and well-referenced review, intended to be informative for the lay reader, as well as for scholars who wish to embark on such research without prior experience. This review begins by discussing the types of research questions relevant to radiation oncology that large-scale databases may help illuminate. It then describes major potential data sources for such endeavors, including information regarding access and insights regarding the strengths and limitations of each. Finally, it provides guidance regarding the analytical challenges that observational studies must confront, along with discussion of the techniques that have been developed to help minimize the impact of certain common analytical issues in observational analysis. Features characterizing a well-designed observational study include clearly defined research questions, careful selection of an appropriate data source, consultation with investigators with relevant methodological expertise, inclusion of sensitivity analyses, caution not to overinterpret small but significant differences, and recognition of limitations when trying to evaluate causality. This review concludes that carefully designed and executed studies using observational data that possess these qualities hold

  7. Observing orbital debris using space-based telescopes. I - Mission orbit considerations

    NASA Technical Reports Server (NTRS)

    Reynolds, Robert C.; Talent, David L.; Vilas, Faith

    1989-01-01

    In this paper, mission orbit considerations are addressed for using the Space Shuttle as a telescope platform for observing man-made orbital debris. Computer modeling of various electrooptical systems predicts that such a space-borne system will be able to detect particles as small as 1-mm diameter. The research is meant to support the development of debris- collision warning sensors through the acquisition of spatial distribution and spectral characteristics for debris and testing of detector combinations on a shuttle-borne telescopic experiment. The technique can also be applied to low-earth-orbit-debris environment monitoring systems. It is shown how the choice of mission orbit, season of launch, and time of day of launch may be employed to provide extended periods of favorable observing conditions.

  8. A discussion of differences in preparation, performance and postreflections in participant observations within two grounded theory approaches.

    PubMed

    Berthelsen, Connie Bøttcher; Lindhardt, Tove; Frederiksen, Kirsten

    2017-06-01

    This paper presents a discussion of the differences in using participant observation as a data collection method by comparing the classic grounded theory methodology of Barney Glaser with the constructivist grounded theory methodology by Kathy Charmaz. Participant observations allow nursing researchers to experience activities and interactions directly in situ. However, using participant observations as a data collection method can be done in many ways, depending on the chosen grounded theory methodology, and may produce different results. This discussion shows that how the differences between using participant observations in classic and constructivist grounded theory can be considerable and that grounded theory researchers should adhere to the method descriptions of performing participant observations according to the selected grounded theory methodology to enhance the quality of research. © 2016 Nordic College of Caring Science.

  9. Regulatory considerations in the design of comparative observational studies using propensity scores.

    PubMed

    Yue, Lilly Q

    2012-01-01

    In the evaluation of medical products, including drugs, biological products, and medical devices, comparative observational studies could play an important role when properly conducted randomized, well-controlled clinical trials are infeasible due to ethical or practical reasons. However, various biases could be introduced at every stage and into every aspect of the observational study, and consequently the interpretation of the resulting statistical inference would be of concern. While there do exist statistical techniques for addressing some of the challenging issues, often based on propensity score methodology, these statistical tools probably have not been as widely employed in prospectively designing observational studies as they should be. There are also times when they are implemented in an unscientific manner, such as performing propensity score model selection for a dataset involving outcome data in the same dataset, so that the integrity of observational study design and the interpretability of outcome analysis results could be compromised. In this paper, regulatory considerations on prospective study design using propensity scores are shared and illustrated with hypothetical examples.

  10. [Pain relief in induced abortion--considerable differences between hospital departments].

    PubMed

    Bäckman, Maria; Hagman, Lill; Lendahls, Lena

    2002-04-18

    Women undergoing medical abortions require different types of pain relief, severe pain being a problem. This study compared the pain relief required during a medical abortion at the Departments of Gynecology in Kalmar and Karlskrona. The case notes of 100 women at each department were examined. Considerable differences between the two departments were found. In Kalmar women were mainly given paracetamol and dextropropoxyphene at the start of the procedure, while in Karlskrona women were usually given suppository diclofenac. In Kalmar 42 per cent of the women needed some form of opiate during the abortion, while in Karlskrona only 8 per cent required opiates.

  11. Methodological considerations in observational comparative effectiveness research for implantable medical devices: an epidemiologic perspective.

    PubMed

    Jalbert, Jessica J; Ritchey, Mary Elizabeth; Mi, Xiaojuan; Chen, Chih-Ying; Hammill, Bradley G; Curtis, Lesley H; Setoguchi, Soko

    2014-11-01

    Medical devices play a vital role in diagnosing, treating, and preventing diseases and are an integral part of the health-care system. Many devices, including implantable medical devices, enter the market through a regulatory pathway that was not designed to assure safety and effectiveness. Several recent studies and high-profile device recalls have demonstrated the need for well-designed, valid postmarketing studies of medical devices. Medical device epidemiology is a relatively new field compared with pharmacoepidemiology, which for decades has been developed to assess the safety and effectiveness of medications. Many methodological considerations in pharmacoepidemiology apply to medical device epidemiology. Fundamental differences in mechanisms of action and use and in how exposure data are captured mean that comparative effectiveness studies of medical devices often necessitate additional and different considerations. In this paper, we discuss some of the most salient issues encountered in conducting comparative effectiveness research on implantable devices. We discuss special methodological considerations regarding the use of data sources, exposure and outcome definitions, timing of exposure, and sources of bias. © The Author 2014. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  12. Privacy considerations in the context of an Australian observational database.

    PubMed

    Duszynski, K M; Beilby, J J; Marley, J E; Walker, D C; Pratt, N L

    2001-12-01

    Observational databases are increasingly acknowledged for their value in clinical investigation. Australian general practice in particular presents an exciting opportunity to examine treatment in a natural setting. The paper explores issues such as privacy and confidentiality--foremost considerations when conducting this form of pharmacoepidemiological research. Australian legislation is currently addressing these exact issues in order to establish clear directives regarding ethical concerns. The development of a pharmacoepidemiological database arising from the integration of computerized Australian general practice records is described in addition, to the challenges associated with creating a database which considers patient privacy. The database known as 'Medic-GP', presently contains more than 950,000 clinical notes (including consultations, pathology, diagnostic imaging and adverse reactions) over a 5-year time period and relates to 55,000 patients. The paper then details a retrospective study which utilized the database to examine the interaction between antibiotic prescribing and patient outcomes from a community perspective, following a policy intervention. This study illustrates the application of computerized general practice records in research.

  13. Continuity of Landsat observations: Short term considerations

    USGS Publications Warehouse

    Wulder, Michael A.; White, Joanne C.; Masek, Jeffery G.; Dwyer, John L.; Roy, David P.

    2011-01-01

    As of writing in mid-2010, both Landsat-5 and -7 continue to function, with sufficient fuel to enable data collection until the launch of the Landsat Data Continuity Mission (LDCM) scheduled for December of 2012. Failure of one or both of Landsat-5 or -7 may result in a lack of Landsat data for a period of time until the 2012 launch. Although the potential risk of a component failure increases the longer the sensor's design life is exceeded, the possible gap in Landsat data acquisition is reduced with each passing day and the risk of Landsat imagery being unavailable diminishes for all except a handful of applications that are particularly data demanding. Advances in Landsat data compositing and fusion are providing opportunities to address issues associated with Landsat-7 SLC-off imagery and to mitigate a potential acquisition gap through the integration of imagery from different sensors. The latter will likely also provide short-term, regional solutions to application-specific needs for the continuity of Landsat-like observations. Our goal in this communication is not to minimize the community's concerns regarding a gap in Landsat observations, but rather to clarify how the current situation has evolved and provide an up-to-date understanding of the circumstances, implications, and mitigation options related to a potential gap in the Landsat data record.

  14. Functional connectivity between somatosensory and motor brain areas predicts individual differences in motor learning by observing.

    PubMed

    McGregor, Heather R; Gribble, Paul L

    2017-08-01

    Action observation can facilitate the acquisition of novel motor skills; however, there is considerable individual variability in the extent to which observation promotes motor learning. Here we tested the hypothesis that individual differences in brain function or structure can predict subsequent observation-related gains in motor learning. Subjects underwent an anatomical MRI scan and resting-state fMRI scans to assess preobservation gray matter volume and preobservation resting-state functional connectivity (FC), respectively. On the following day, subjects observed a video of a tutor adapting her reaches to a novel force field. After observation, subjects performed reaches in a force field as a behavioral assessment of gains in motor learning resulting from observation. We found that individual differences in resting-state FC, but not gray matter volume, predicted postobservation gains in motor learning. Preobservation resting-state FC between left primary somatosensory cortex and bilateral dorsal premotor cortex, primary motor cortex, and primary somatosensory cortex and left superior parietal lobule was positively correlated with behavioral measures of postobservation motor learning. Sensory-motor resting-state FC can thus predict the extent to which observation will promote subsequent motor learning. NEW & NOTEWORTHY We show that individual differences in preobservation brain function can predict subsequent observation-related gains in motor learning. Preobservation resting-state functional connectivity within a sensory-motor network may be used as a biomarker for the extent to which observation promotes motor learning. This kind of information may be useful if observation is to be used as a way to boost neuroplasticity and sensory-motor recovery for patients undergoing rehabilitation for diseases that impair movement such as stroke. Copyright © 2017 the American Physiological Society.

  15. Observing the ocean with different platforms/methods. Advantages, disadvantages and lessons learnt

    NASA Astrophysics Data System (ADS)

    Petihakis, George; Potiris, Manolis; Ntoumas, Manolis; Frangoulis, Kostas; Tsiaras, Kostas; Triantafyllou, George; Pollani, Annika

    2015-04-01

    Methods for observing/measuring the ocean, present remarkable diversity. In situ sampling or remote sensing, automated or not measurements with sensing probes, utilize different measuring principles, sample different parts of the system, are characterized by different accuracy/precision and sample over a large range of spatial and temporal scales with variable resolution. Measurements, quite often are dependent on the platform design and the platform interaction with the highly variable ambient environment. To add to the aforementioned issues that render the combination of data from different sources challenging from a scientific perspective, there are also a number of technical and data issues. These are important for the good operational status of the platforms, the smooth data flow and the collection of appropriate meta-data. Finally the raw data files need to be processed into a user friendly output format so the operator will be able to identify as early as possible sensor drift and failures. In this work, data from different observation platforms/sensors is analysed and compared, while mechanisms and processes responsible for differences are identified. More detailed, temperature, salinity and chlorophyll data from four fixed observing stations, one Ferry Box, satellites and a monthly in situ sampling program, is used. Main results indicate that a) regular calibration according to expected parameter range and well-defined, consistent deployment plan of proven sensors is sufficient for acquiring high quality data in the long term. Better knowledge of site specific response of new instrumentation is required for producing consistent long term data b) duplicate sensors on one platform considerably improve data flow and data quality c) if an area is sampled by multiple platforms, then platform dependent errors can be quantified d) fixed point observatories are efficient tools for assessing regional performance of satellite products. Higher vertical and temporal

  16. Inter-observer variability in diagnosing radiological features of aneurysmal subarachnoid hemorrhage; a preliminary single centre study comparing observers from different specialties and levels of training.

    PubMed

    Siddiqui, Usman T; Khan, Anjum F; Shamim, Muhammad Shahzad; Hamid, Rana Shoaib; Alam, Muhammad Mehboob; Emaduddin, Muhammad

    2014-01-01

    A noncontrast computed tomography (CT) scan remains the initial radiological investigation of choice for a patient with suspected aneurysmal subarachnoid hemorrhage (aSAH). This initial scan may be used to derive key information about the underlying aneurysm which may aid in further management. The interpretation, however, is subject to the skill and experience of the interpreting individual. The authors here evaluate the interpretation of such CT scans by different individuals at different levels of training, and in two different specialties (Radiology and Neurosurgery). Initial nonontrast CT scan of 35 patients with aSAH was evaluated independently by four different observers. The observers selected for the study included two from Radiology and two from Neurosurgery at different levels of training; a resident currently in mid training and a resident who had recently graduated from training of each specialty. Measured variables included interpreter's suspicion of presence of subarachnoid blood, side of the subarachnoid hemorrhage, location of the aneurysm, the aneurysm's proximity to vessel bifurcation, number of aneurysm(s), contour of aneurysm(s), presence of intraventricular hemorrhage (IVH), intracerebral hemorrhage (ICH), infarction, hydrocephalus and midline shift. To determine the inter-observer variability (IOV), weighted kappa values were calculated. There was moderate agreement on most of the CT scan findings among all observers. Substantial agreement was found amongst all observers for hydrocephalus, IVH, and ICH. Lowest agreement rates were seen in the location of aneurysm being supra or infra tentorial. There were, however, some noteworthy exceptions. There was substantial to almost perfect agreement between the radiology graduate and radiology resident on most CT findings. The lowest agreement was found between the neurosurgery graduate and the radiology graduate. Our study suggests that although agreements were seen in the interpretation of some of

  17. Aerobiology: Experimental Considerations, Observations, and Future Tools

    PubMed Central

    Haddrell, Allen E.

    2017-01-01

    ABSTRACT Understanding airborne survival and decay of microorganisms is important for a range of public health and biodefense applications, including epidemiological and risk analysis modeling. Techniques for experimental aerosol generation, retention in the aerosol phase, and sampling require careful consideration and understanding so that they are representative of the conditions the bioaerosol would experience in the environment. This review explores the current understanding of atmospheric transport in relation to advances and limitations of aerosol generation, maintenance in the aerosol phase, and sampling techniques. Potential tools for the future are examined at the interface between atmospheric chemistry, aerosol physics, and molecular microbiology where the heterogeneity and variability of aerosols can be explored at the single-droplet and single-microorganism levels within a bioaerosol. The review highlights the importance of method comparison and validation in bioaerosol research and the benefits that the application of novel techniques could bring to increasing the understanding of aerobiological phenomena in diverse research fields, particularly during the progression of atmospheric transport, where complex interdependent physicochemical and biological processes occur within bioaerosol particles. PMID:28667111

  18. Differences between the MEMLS and the multiple-layer HUT model and their comparisons with in-situ snowpack observations

    NASA Astrophysics Data System (ADS)

    Pan, J.; Durand, M. T.; Sandells, M. J.; Lemmetyinen, J.; Kim, E. J.

    2013-12-01

    Application of passive microwave (PM) brightness temperature for snow water equivalent retrieval requires deep understanding of snow emission models, not only for their performance to reproduce in-situ PM observations, but also for their theoretical differences to approximate radiative transfer theory. In this paper, differences between the multiple-layer HUT (or TKK) model and the Microwave Emission Model of Layered Snowpacks (MEMLS) were listed, and the two models were compared with snow ground-based PM observations at Streamboat Springs, Colorado, USA; Churchill, Canada; and Sodankyla, Finland. The two models were chosen for their multiple-layer schemes are close to actual layer-by-layer snow measurements. Both the two models are semi-empirical models; whereas the HUT model uses the mean snow grain size, MEMLS uses the correlation length to relate the snow microstructure with the scattering coefficients. The two parameters are related according to previous studies. The Specific Surface Area (SSA) was measured at three test sites to derive the correlation length, while the mean snow grain sizes was available at Stream Springs and Sodankyla. It was shown that with different apparent forms of radiative transfer equations, the different parts of the two models have one-to-one correspondence however, and intermediate parameters are comparable. Regarding the multiple-layer structure of the models, it was found that the HUT model considers the internal reflectivity of each snow layer to be zero. The two-flux radiative transfer equations of the two models were compared, and the correspondence of the semi-empirical parameter q in the HUT model was found in the MEMLS. The effect of consideration of transverse radiation scattered into the direction under consideration via the six-flux approximation in MEMLS is compared. Based on model comparisons, we analyzed the differences of TB predictions at the three test sites.

  19. On the Diurnal Periodicity of Representative Earthquakes in Greece: Comparison of Data from Different Observation Systems

    NASA Astrophysics Data System (ADS)

    Desherevskii, A. V.; Sidorin, A. Ya.

    2017-12-01

    Due to the initiation of the Hellenic Unified Seismic Network (HUSN) in late 2007, the quality of observation significantly improved by 2011. For example, the representative magnitude level considerably has decreased and the number of annually recorded events has increased. The new observational system highly expanded the possibilities for studying regularities in seismicity. In view of this, the authors revisited their studies of the diurnal periodicity of representative earthquakes in Greece that was revealed earlier in the earthquake catalog before 2011. We use 18 samples of earthquakes of different magnitudes taken from the catalog of Greek earthquakes from 2011 to June 2016 to derive a series of the number of earthquakes for each of them and calculate its average diurnal course. To increase the reliability of the results, we compared the data for two regions. With a high degree of statistical significance, we have obtained that no diurnal periodicity can be found for strongly representative earthquakes. This finding differs from the estimates obtained earlier from an analysis of the catalog of earthquakes at the same area for 1995-2004 and 2005-2010, i.e., before the initiation of the Hellenic Unified Seismic Network. The new results are consistent with the hypothesis of noise discrimination (observational selection) explaining the cause of the diurnal variation of earthquakes with different sensitivity of the seismic network in daytime and nighttime periods.

  20. Effects of Different Observational Systems and Time Sequences Upon Non-Participant Observers' Behavioral Ratings.

    ERIC Educational Resources Information Center

    Wodarski, John S.; And Others

    Four different observational systems and two time sequences were employed to determine the extent to which they would yield different incidences of anti-social behavior. Two videotapes, randomly chosen from a pool of 30 tapes, were utilized. These illustrated the behaviors of anti-social children in a natural setting. Six observers were reliably…

  1. Collegiality and commerce: The culture of consideration amongst engineers

    NASA Astrophysics Data System (ADS)

    Nugent, Paul David

    This study is a participant observation ethnography of engineering relationships at a defense contracting plant that specializes in the design and manufacture of launch control systems for nuclear submarines. "Consideration" is presented as a unique mode of interaction enabling resource exchange and pivotal in developing and strengthening work relationships. Consideration differs from other modes of exchange such as markets, gift-giving, and charity primarily in that the bestowal of the resource involves little sacrifice. The manner in which consideration is enacted by the engineers, the structural and cultural conditions supporting consideration, and the social and economic consequences of consideration are presented. From these findings it is concluded that consideration is a unique form of economic exchange embedded in concrete relationships that forces us to rethink and extend current conceptualizations of trust, networks, social capital, and friendship in the workplace. The data for the analysis were drawn from twenty interviews and fieldnotes collected and transcribed over a twelve month period. Quotations from the interviews and exerpts from the fieldnotes are included to illustrate claims being made in the analysis as well as to familiarize the reader with the culture developed by engineers and managers in a defense contracting plant.

  2. Spectroradiometric considerations for advanced land observing systems

    NASA Technical Reports Server (NTRS)

    Slater, P. N.

    1986-01-01

    Research aimed at improving the inflight absolute radiometric calibration of advanced land observing systems was initiated. Emphasis was on the satellite sensor calibration program at White Sands. Topics addressed include: absolute radiometric calibration of advanced remote sensing; atmospheric effects on reflected radiation; inflight radiometric calibration; field radiometric methods for reflectance and atmospheric measurement; and calibration of field relectance radiometers.

  3. Sample size considerations for paired experimental design with incomplete observations of continuous outcomes.

    PubMed

    Zhu, Hong; Xu, Xiaohan; Ahn, Chul

    2017-01-01

    Paired experimental design is widely used in clinical and health behavioral studies, where each study unit contributes a pair of observations. Investigators often encounter incomplete observations of paired outcomes in the data collected. Some study units contribute complete pairs of observations, while the others contribute either pre- or post-intervention observations. Statistical inference for paired experimental design with incomplete observations of continuous outcomes has been extensively studied in literature. However, sample size method for such study design is sparsely available. We derive a closed-form sample size formula based on the generalized estimating equation approach by treating the incomplete observations as missing data in a linear model. The proposed method properly accounts for the impact of mixed structure of observed data: a combination of paired and unpaired outcomes. The sample size formula is flexible to accommodate different missing patterns, magnitude of missingness, and correlation parameter values. We demonstrate that under complete observations, the proposed generalized estimating equation sample size estimate is the same as that based on the paired t-test. In the presence of missing data, the proposed method would lead to a more accurate sample size estimate comparing with the crude adjustment. Simulation studies are conducted to evaluate the finite-sample performance of the generalized estimating equation sample size formula. A real application example is presented for illustration.

  4. Emotional experience in the mornings and the evenings: consideration of age differences in specific emotions by time of day.

    PubMed

    English, Tammy; Carstensen, Laura L

    2014-01-01

    Considerable evidence points to age-related improvements in emotional well-being with age. In order to gain a more nuanced understanding of the nature of these apparent shifts in experience, we examined age differences in a range of emotional states in the mornings and evenings in a sample of 135 community-residing participants across 10 consecutive days. Participants ranged in age from 22 to 93 years. Each participant completed a diary in the morning and again in the evening every day for the study period. During each of the assessments, participants reported the degree to which they experienced emotions sampled from all four quadrants of the affective circumplex. Overall, participants felt less positive and more negative in the evenings than in the mornings. As expected, older adults reported a relatively more positive emotional experience than younger adults at both times of day. Importantly, however, age effects varied based on emotion type and time of day. Older adults reported experiencing more positive emotion than relatively younger adults across a range of different positive states (although age differences emerged most consistently for low arousal positive states). Age-related reductions in negative experience were observed only for reports of low arousal negative emotions. There were no age differences in anger, anxiety, or sadness. For some emotions, age differences were stronger in the mornings (e.g., relaxed) whereas for other emotions age differences were more pronounced in the evenings (e.g., enthusiastic). Findings are discussed in the context of adulthood changes in motivation and emotional experience.

  5. Emotional experience in the mornings and the evenings: consideration of age differences in specific emotions by time of day

    PubMed Central

    English, Tammy; Carstensen, Laura L.

    2014-01-01

    Considerable evidence points to age-related improvements in emotional well-being with age. In order to gain a more nuanced understanding of the nature of these apparent shifts in experience, we examined age differences in a range of emotional states in the mornings and evenings in a sample of 135 community-residing participants across 10 consecutive days. Participants ranged in age from 22 to 93 years. Each participant completed a diary in the morning and again in the evening every day for the study period. During each of the assessments, participants reported the degree to which they experienced emotions sampled from all four quadrants of the affective circumplex. Overall, participants felt less positive and more negative in the evenings than in the mornings. As expected, older adults reported a relatively more positive emotional experience than younger adults at both times of day. Importantly, however, age effects varied based on emotion type and time of day. Older adults reported experiencing more positive emotion than relatively younger adults across a range of different positive states (although age differences emerged most consistently for low arousal positive states). Age-related reductions in negative experience were observed only for reports of low arousal negative emotions. There were no age differences in anger, anxiety, or sadness. For some emotions, age differences were stronger in the mornings (e.g., relaxed) whereas for other emotions age differences were more pronounced in the evenings (e.g., enthusiastic). Findings are discussed in the context of adulthood changes in motivation and emotional experience. PMID:24639663

  6. Does consideration of either psychological or material disadvantage improve coronary risk prediction? Prospective observational study of Scottish men.

    PubMed

    Macleod, John; Metcalfe, Chris; Smith, George Davey; Hart, Carole

    2007-09-01

    To assess the value of psychosocial risk factors in discriminating between individuals at higher and lower risk of coronary heart disease, using risk prediction equations. Prospective observational study. Scotland. 5191 employed men aged 35 to 64 years and free of coronary heart disease at study enrollment Area under receiver operating characteristic (ROC) curves for risk prediction equations including different risk factors for coronary heart disease. During the first 10 years of follow up, 203 men died of coronary heart disease and a further 200 were admitted to hospital with this diagnosis. Area under the ROC curve for the standard Framingham coronary risk factors was 74.5%. Addition of "vital exhaustion" and psychological stress led to areas under the ROC curve of 74.5% and 74.6%, respectively. Addition of current social class and lifetime social class to the standard Framingham equation gave areas under the ROC curve of 74.6% and 74.9%, respectively. In no case was there strong evidence for improved discrimination of the model containing the novel risk factor over the standard model. Consideration of psychosocial risk factors, including those that are strong independent predictors of heart disease, does not substantially influence the ability of risk prediction tools to discriminate between individuals at higher and lower risk of coronary heart disease.

  7. Sustainability Considerations for Health Research and Analytic Data Infrastructures

    PubMed Central

    Wilcox, Adam; Randhawa, Gurvaneet; Embi, Peter; Cao, Hui; Kuperman, Gilad J.

    2014-01-01

    Introduction: The United States has made recent large investments in creating data infrastructures to support the important goals of patient-centered outcomes research (PCOR) and comparative effectiveness research (CER), with still more investment planned. These initial investments, while critical to the creation of the infrastructures, are not expected to sustain them much beyond the initial development. To provide the maximum benefit, the infrastructures need to be sustained through innovative financing models while providing value to PCOR and CER researchers. Sustainability Factors: Based on our experience with creating flexible sustainability strategies (i.e., strategies that are adaptive to the different characteristics and opportunities of a resource or infrastructure), we define specific factors that are important considerations in developing a sustainability strategy. These factors include assets, expansion, complexity, and stakeholders. Each factor is described, with examples of how it is applied. These factors are dimensions of variation in different resources, to which a sustainability strategy should adapt. Summary Observations: We also identify specific important considerations for maintaining an infrastructure, so that the long-term intended benefits can be realized. These observations are presented as lessons learned, to be applied to other sustainability efforts. We define the lessons learned, relating them to the defined sustainability factors as interactions between factors. Conclusion and Next Steps: Using perspectives and experiences from a diverse group of experts, we define broad characteristics of sustainability strategies and important observations, which can vary for different projects. Other descriptions of adaptive, flexible, and successful models of collaboration between stakeholders and data infrastructures can expand this framework by identifying other factors for sustainability, and give more concrete directions on how sustainability

  8. Figure of merit and different combinations of observational data sets

    NASA Astrophysics Data System (ADS)

    Su, Qiping; Tuo, Zhong-Liang; Cai, Rong-Gen

    2011-11-01

    To constrain cosmological parameters, one often makes a joint analysis with different combinations of observational data sets. In this paper we take the figure of merit (FoM) for Dark Energy Task Force fiducial model (Chevallier-Polarski-Linder model) to estimate goodness of different combinations of data sets, which include 11 widely used observational data sets (type Ia supernovae, observational hubble parameter, baryon acoustic oscillation, cosmic microwave background, x-ray cluster baryon mass fraction, and gamma-ray bursts). We analyze different combinations and make a comparison for two types of combinations based on two types of basic combinations, which are often adopted in the literature. We find two sets of combinations, which have a strong ability to constrain the dark energy parameters: one has the largest FoM, and the other contains less observational data with a relatively large FoM and a simple fitting procedure.

  9. Biases and systematics in the observational derivation of galaxy properties: comparing different techniques on synthetic observations of simulated galaxies

    NASA Astrophysics Data System (ADS)

    Guidi, Giovanni; Scannapieco, Cecilia; Walcher, C. Jakob

    2015-12-01

    We study the sources of biases and systematics in the derivation of galaxy properties from observational studies, focusing on stellar masses, star formation rates, gas and stellar metallicities, stellar ages, magnitudes and colours. We use hydrodynamical cosmological simulations of galaxy formation, for which the real quantities are known, and apply observational techniques to derive the observables. We also analyse biases that are relevant for a proper comparison between simulations and observations. For our study, we post-process the simulation outputs to calculate the galaxies' spectral energy distributions (SEDs) using stellar population synthesis models and also generate the fully consistent far-UV-submillimetre wavelength SEDs with the radiative transfer code SUNRISE. We compared the direct results of simulations with the observationally derived quantities obtained in various ways, and found that systematic differences in all studied galaxy properties appear, which are caused by: (1) purely observational biases, (2) the use of mass-weighted and luminosity-weighted quantities, with preferential sampling of more massive and luminous regions, (3) the different ways of constructing the template of models when a fit to the spectra is performed, and (4) variations due to different calibrations, most notably for gas metallicities and star formation rates. Our results show that large differences can appear depending on the technique used to derive galaxy properties. Understanding these differences is of primary importance both for simulators, to allow a better judgement of similarities and differences with observations, and for observers, to allow a proper interpretation of the data.

  10. Large 0/12 GMT Differences of US Vaisala RS80 Observations

    NASA Technical Reports Server (NTRS)

    Atlas, Robert (Technical Monitor)

    2002-01-01

    Large differences been observations taken at 0 and 12 GMT have been revealed during routine monitoring of observations at the Data Assimilation Office (DAO) at NASA's Goddard Space Flight Center (GSFC). As a result, an investigation has been conducted to confirm the large differences and isolate its source. The data clearly shows that 0/12 GMT differences are largely artificial especially over the central US and that the differences largely originate in the post processing software at the observing stations. In particular, the release time of the rawinsonde balloon may be misspecified to be the synoptic time which would lead to the miscalculation of the bias correction that accounts for solar radiation effects on the thermistor.

  11. Are There Differences between Children's Display of Self-Regulation and Metacognition When Engaged in an Activity and When Later Reflecting on It? The Complementary Roles of Observation and Reflective Dialogue

    ERIC Educational Resources Information Center

    Robson, Sue

    2016-01-01

    Recent years have seen considerable growth of evidence that young children possess metacognitive and self-regulatory skills, alongside a view that some research tools, including observation and video-stimulated interviews, may provide better opportunities to see them. This paper examines possible differences in the evidence these two tools may…

  12. Geographic differences in fractures among women

    PubMed Central

    Litwic, Anna; Edwards, Mark; Cooper, Cyrus; Dennison, Elaine

    2013-01-01

    Osteoporotic fracture is associated with considerable morbidity and mortality in women throughout the world. However, significant variation in hip fracture rates among women from different nations have been observed, and are likely to represent a combination of real and apparent differences due to ascertainment bias. Higher rates are observed in Caucasian women, with lowest rates observed in black women and intermediate rates among Asian women. These differences are likely to represent a combination of genetic and environmental differences; for example, among European women, the highest fracture rates are observed in Scandinavian women where vitamin D insufficiency is common. In all groups, an expansion in absolute fracture numbers is anticipated due to demographic changes. PMID:23181532

  13. Differing forms, differing purposes: A typology of health impact assessment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Harris-Roxas, Ben, E-mail: b.harris-roxas@unsw.edu.au; Harris, Elizabeth, E-mail: e.harris@unsw.edu.a

    2011-07-15

    There is currently considerable diversity in health impact assessment (HIA) practice internationally. Historically this diversity has been described as simple dichotomies, for example the differences between HIAs of projects and policies. However these distinctions have failed to adequately describe the differences that can be observed between different forms of HIAs. This paper describes the three historical and disciplinary fields from which HIA has emerged - environmental health, a social view of health, and health equity. It also puts forward a typology of four different forms of HIA that can be observed in current HIA practice: mandated, decision-support, advocacy, and community-ledmore » HIAs. This paper argues that these different forms of HIA serve different purposes and are not necessarily in competition; rather they allow HIA to be responsive to a range of population health concerns and purposes.« less

  14. No difference in mitochondrial distribution is observed in human oocytes after cryopreservation.

    PubMed

    Stimpfel, Martin; Vrtacnik-Bokal, Eda; Virant-Klun, Irma

    2017-08-01

    The primary aim of this study was to determine if any difference in mitochondrial distribution can be observed between fresh and cryopreserved (slow-frozen/thawed and vitrified/warmed) oocytes when oocytes are stained with Mitotracker Red CMXRos and observed under a conventional fluorescent microscope. Additionally, the influence of cryopreservation procedure on the viable rates of oocytes at different maturation stages was evaluated. The germinal vesicle (GV) and MII oocytes were cryopreserved with slow-freezing and vitrification. After thawing/warming, oocytes were stained using Mitotracker Red CMXRos and observed under a conventional fluorescent microscope. Mitotracker staining revealed that in GV oocytes the pattern of mitochondrial distribution appeared as aggregated clusters around the whole oocyte. In mature MII oocytes, three different patterns of mitochondrial distribution were observed; a smooth pattern around the polar body with aggregated clusters at the opposite side of the polar body, a smooth pattern throughout the whole cell, and aggregated clusters as can be seen in GV oocytes. There were no significant differences in the observed patterns between fresh, vitrified/warmed and frozen/thawed oocytes. When comparing the viable rates of oocytes after two different cryopreservation procedures, the results showed no significant differences, although the trend of viable MII oocytes tends to be higher after vitrification/warming and for viable GV oocytes it tends to be higher after slow-freezing/thawing. Mitotracker Red CMXRos staining of mitochondria in oocytes did not reveal differences in mitochondrial distribution between fresh and cryopreserved oocytes at different maturity stages. Additionally, no difference was observed in the viable rates of GV and MII oocytes after slow-freezing/thawing and vitrification/warming.

  15. Green Power Procurement Considerations

    EPA Pesticide Factsheets

    Green power products are available from a variety of different vendors, including utilities, renewable energy certificate (REC) marketers, on-site system integrators, and non-profit organizations. This page lists considerations to evaluate during selection

  16. Constraining Cosmological Models with Different Observations

    NASA Astrophysics Data System (ADS)

    Wei, J. J.

    2016-07-01

    With the observations of Type Ia supernovae (SNe Ia), scientists discovered that the Universe is experiencing an accelerated expansion, and then revealed the existence of dark energy in 1998. Since the amazing discovery, cosmology has became a hot topic in the physical research field. Cosmology is a subject that strongly depends on the astronomical observations. Therefore, constraining different cosmological models with all kinds of observations is one of the most important research works in the modern cosmology. The goal of this thesis is to investigate cosmology using the latest observations. The observations include SNe Ia, Type Ic Super Luminous supernovae (SLSN Ic), Gamma-ray bursts (GRBs), angular diameter distance of galaxy cluster, strong gravitational lensing, and age measurements of old passive galaxies, etc. In Chapter 1, we briefly review the research background of cosmology, and introduce some cosmological models. Then we summarize the progress on cosmology from all kinds of observations in more details. In Chapter 2, we present the results of our studies on the supernova cosmology. The main difficulty with the use of SNe Ia as standard candles is that one must optimize three or four nuisance parameters characterizing SN luminosities simultaneously with the parameters of an expansion model of the Universe. We have confirmed that one should optimize all of the parameters by carrying out the method of maximum likelihood estimation in any situation where the parameters include an unknown intrinsic dispersion. The commonly used method, which estimates the dispersion by requiring the reduced χ^{2} to equal unity, does not take into account all possible variances among the parameters. We carry out such a comparison of the standard ΛCDM cosmology and the R_{h}=ct Universe using the SN Legacy Survey sample of 252 SN events, and show that each model fits its individually reduced data very well. Moreover, it is quite evident that SLSNe Ic may be useful

  17. Large 0/12 GMT Differences of US Vaisala RS80 Observations

    NASA Technical Reports Server (NTRS)

    Redder, Chris; Atlas, Robert (Technical Monitor)

    2002-01-01

    The daily differences between the temperatures and heights taken at 0 GMT and 12 GMT by Vaisala RS80 rawinsondes have been calculated. The observations were obtained during selected months from 1998 - 2002 over North America, Europe and Australia. The daily differences are defined by the formula, Delta T = Delta T(sub 0) - 0.5(T(sub -12) - T(sub +12)) where AT is the 0/12 GMT difference, T(sub 0) is the 0 GMT observation and T(sub -12) and T(sub +12) are the 12 GMT observations taken just prior and after the 0 GMT synoptic time. If T(sub +12) is missing then Delta T = T(sub 0) - T(sub -12). A similar expression is used if T(sub -12) is missing. Monthly averages of the increments at each station that launch RS80 rawinsondes are then calculated. The results show positive systematic differences in the stratosphere with values as high as 5 K and 150 m at 10 hPa over the central United States. The values remain generally positive and gradually decrease as the levels descend into the upper troposphere but are still significant. In addition, the maximum at each level is just westward of 90 W at the highest levels and just eastward in the troposphere with smaller values along both coasts. In Canada as well as in Europe and Australia the differences are much smaller with no systematic patterns similar to those that exist over the contiguous United States. Time-series plots of the temperatures and heights at select stations in the United States show that the observed values taken at 0 GMT are consistently higher than those at 12 GMT. Over Canada the differences become much less apparent and some cases non-existent. The observations were obtained through National Centers for Environmental Prediction (NCEP) but were checked with data from other sources to verify that no modifications were made other than those at the stations. Since the data from outside the the United States exhibit no large systematic differences, the preliminary conclusion is that the large differences are

  18. Sustainability considerations for health research and analytic data infrastructures.

    PubMed

    Wilcox, Adam; Randhawa, Gurvaneet; Embi, Peter; Cao, Hui; Kuperman, Gilad J

    2014-01-01

    The United States has made recent large investments in creating data infrastructures to support the important goals of patient-centered outcomes research (PCOR) and comparative effectiveness research (CER), with still more investment planned. These initial investments, while critical to the creation of the infrastructures, are not expected to sustain them much beyond the initial development. To provide the maximum benefit, the infrastructures need to be sustained through innovative financing models while providing value to PCOR and CER researchers. Based on our experience with creating flexible sustainability strategies (i.e., strategies that are adaptive to the different characteristics and opportunities of a resource or infrastructure), we define specific factors that are important considerations in developing a sustainability strategy. These factors include assets, expansion, complexity, and stakeholders. Each factor is described, with examples of how it is applied. These factors are dimensions of variation in different resources, to which a sustainability strategy should adapt. We also identify specific important considerations for maintaining an infrastructure, so that the long-term intended benefits can be realized. These observations are presented as lessons learned, to be applied to other sustainability efforts. We define the lessons learned, relating them to the defined sustainability factors as interactions between factors. Using perspectives and experiences from a diverse group of experts, we define broad characteristics of sustainability strategies and important observations, which can vary for different projects. Other descriptions of adaptive, flexible, and successful models of collaboration between stakeholders and data infrastructures can expand this framework by identifying other factors for sustainability, and give more concrete directions on how sustainability can be best achieved.

  19. Observation Care: Ethical and Legal Considerations for the Emergency Physician.

    PubMed

    Ali, Nissa J; Jesus, John; Smulowitz, Peter B

    2016-03-01

    The Medicare observation rules remain controversial despite Centers for Medicare and Medicaid Services revisions and the new 2-midnight rule. The increased financial risks for patients and heightened awareness of the rule have placed emergency physicians (EPs) at the center of the controversy. This article reviews the primary ethical and legal (particularly with respect to the Emergency Medical Treatment and Active Labor Act) implications of the existing observation rule for EPs and offers practical solutions for EPs faced with counseling patients on the meaning and ramifications of the observation rule. We conclude that while we believe it does not violate the intent of the Emergency Medical Treatment and Active Labor Act to respond to patient questions about their admission status, the observation rules challenge the ethical principles of transparency related to the physician-patient relationship and justice as fairness. Guidance for physicians is offered to improve transparency and patient fairness. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. The Epidemiology of Observed Temperament: Factor Structure and Demographic Group Differences

    PubMed Central

    Willoughby, Michael T.; Stifter, Cynthia A.; Gottfredson, Nisha C.

    2015-01-01

    This study investigated the factor structure of observational indicators of children’s temperament that were collected across the first three years of life in the Family Life Project (N = 1205) sample. A four-factor model (activity level, fear, anger, regulation), which corresponded broadly to Rothbart’s distinction between reactivity and regulation, provided an acceptable fit the observed data. Tests of measurement invariance demonstrated that a majority of the observational indicators exhibited comparable measurement properties for male vs. female, black vs. white, and poor vs. not-poor children, which improved the generalizability of these results. Unadjusted demographic group comparisons revealed small to moderate sized differences (Cohen ds = |.23 – .42|) in temperamental reactivity and moderate to large sized differences (Cohen ds = −.64 – −.97) in regulation. Collectively, demographic variables explained more of the variation in regulation (R2 = .25) than in reactivity (R2 = .02 – .06). Follow-up analyses demonstrated that race differences were substantially diminished in magnitude and better accounted for by poverty. These results help to validate the distinction between temperamental reactivity and regulation using observational indicators. PMID:25733489

  1. Muscle Force-Velocity Relationships Observed in Four Different Functional Tests.

    PubMed

    Zivkovic, Milena Z; Djuric, Sasa; Cuk, Ivan; Suzovic, Dejan; Jaric, Slobodan

    2017-02-01

    The aims of the present study were to investigate the shape and strength of the force-velocity relationships observed in different functional movement tests and explore the parameters depicting force, velocity and power producing capacities of the tested muscles. Twelve subjects were tested on maximum performance in vertical jumps, cycling, bench press throws, and bench pulls performed against different loads. Thereafter, both the averaged and maximum force and velocity variables recorded from individual trials were used for force-velocity relationship modeling. The observed individual force-velocity relationships were exceptionally strong (median correlation coefficients ranged from r = 0.930 to r = 0.995) and approximately linear independently of the test and variable type. Most of the relationship parameters observed from the averaged and maximum force and velocity variable types were strongly related in all tests (r = 0.789-0.991), except for those in vertical jumps (r = 0.485-0.930). However, the generalizability of the force-velocity relationship parameters depicting maximum force, velocity and power of the tested muscles across different tests was inconsistent and on average moderate. We concluded that the linear force-velocity relationship model based on either maximum or averaged force-velocity data could provide the outcomes depicting force, velocity and power generating capacity of the tested muscles, although such outcomes can only be partially generalized across different muscles.

  2. Muscle Force-Velocity Relationships Observed in Four Different Functional Tests

    PubMed Central

    Zivkovic, Milena Z.; Djuric, Sasa; Cuk, Ivan; Suzovic, Dejan; Jaric, Slobodan

    2017-01-01

    Abstract The aims of the present study were to investigate the shape and strength of the force-velocity relationships observed in different functional movement tests and explore the parameters depicting force, velocity and power producing capacities of the tested muscles. Twelve subjects were tested on maximum performance in vertical jumps, cycling, bench press throws, and bench pulls performed against different loads. Thereafter, both the averaged and maximum force and velocity variables recorded from individual trials were used for force–velocity relationship modeling. The observed individual force-velocity relationships were exceptionally strong (median correlation coefficients ranged from r = 0.930 to r = 0.995) and approximately linear independently of the test and variable type. Most of the relationship parameters observed from the averaged and maximum force and velocity variable types were strongly related in all tests (r = 0.789-0.991), except for those in vertical jumps (r = 0.485-0.930). However, the generalizability of the force-velocity relationship parameters depicting maximum force, velocity and power of the tested muscles across different tests was inconsistent and on average moderate. We concluded that the linear force-velocity relationship model based on either maximum or averaged force-velocity data could provide the outcomes depicting force, velocity and power generating capacity of the tested muscles, although such outcomes can only be partially generalized across different muscles. PMID:28469742

  3. Tracheostomy: pediatric considerations.

    PubMed

    Deutsch, Ellen S

    2010-08-01

    Pediatric patients for whom tracheotomy is a consideration have different anatomy, medical conditions, and prognoses than adults; even the tracheotomy tubes are different. Indications for pediatric tracheotomy generally include bypassing airway obstruction, providing access for prolonged mechanical ventilation, and facilitating tracheobronchial toilet. Subglottic stenosis is an important indication for tracheotomy in children; its etiology, prevention, and alternative options for management are presented. Discussion includes the benefits, risks, impact on families, techniques for tracheotomy tube changes, and alternatives to tracheotomy, with illustrative photographs and diagrams.

  4. Human factors workplace considerations

    NASA Technical Reports Server (NTRS)

    Haines, Richard F.

    1988-01-01

    Computer workstations assume many different forms and play different functions today. In order for them to assume the effective interface role which they should play they must be properly designed to take into account the ubiguitous human factor. In addition, the entire workplace in which they are used should be properly configured so as to enhance the operational features of the individual workstation where possible. A number of general human factors workplace considerations are presented. This ongoing series of notes covers such topics as achieving comfort and good screen visibility, hardware issues (e.g., mouse maintenance), screen symbology features (e.g., labels, cursors, prompts), and various miscellaneous subjects. These notes are presented here in order to: (1) illustrate how one's workstation can be used to support telescience activities of many other people working within an organization, and (2) provide a single complete set of considerations for future reference.

  5. Obtaining the Greatest Scientific Benefit from Observational Platforms by Consideration of the Relative Benefit of Observations

    NASA Technical Reports Server (NTRS)

    Chelberg, David; Drews, Frank; Fleeman, David; Welch, Lonnie; Marquart, Jane; Pfarr, Barbara

    2003-01-01

    One of the current trends in spacecraft software design is to increase the autonomy of onboard flight and science software. This is especially true when real-time observations may affect the observation schedule of a mission. For many science missions, such as those conducted by the Swift Burst Alert Telescope, the ability of the spacecraft to autonomously respond in real-time to unpredicted science events is crucial for mission success. We apply utility theory within resource management middleware to optimize the real-time performance of application software and achieve maximum system level benefit. We then explore how this methodology can be extended to manage both software and observational resources onboard a spacecraft to achieve the best possible observations.

  6. Observability of Automata Networks: Fixed and Switching Cases.

    PubMed

    Li, Rui; Hong, Yiguang; Wang, Xingyuan

    2018-04-01

    Automata networks are a class of fully discrete dynamical systems, which have received considerable interest in various different areas. This brief addresses the observability of automata networks and switched automata networks in a unified framework, and proposes simple necessary and sufficient conditions for observability. The results are achieved by employing methods from symbolic computation, and are suited for implementation using computer algebra systems. Several examples are presented to demonstrate the application of the results.

  7. Sensor performance considerations for aviation weather observations for the NOAA Consolidated Observations Requirements List (CORL CT-AWX)

    NASA Astrophysics Data System (ADS)

    Murray, John; Helms, David; Miner, Cecilia

    2008-08-01

    Airspace system demand is expected to increase as much as 300 percent by the year 2025 and the Next Generation Air Transportation System (NextGen) is being developed to accommodate the super-density operations that this will entail. Concomitantly, significant improvements in observations and forecasting are being undertaken to support NextGen which will require greatly improved and more uniformly applied data for aviation weather hazards and constraints which typically comprise storm-scale and microscale observables. Various phenomena are associated with these hazards and constraints such as convective weather, in-flight icing, turbulence, and volcanic ash as well as more mundane aviation parameters such as cloud tops and bases and fuel-freeze temperatures at various flight levels. Emerging problems for aviation in space weather and the environmental impacts of aviation are also occurring at these scales. Until recently, the threshold and objective observational requirements for these observables had not been comprehensively documented in a single, authoritative source. Scientists at NASA and NOAA have recently completed this task and have established baseline observational requirements for the Next Generation Air Transportation System (NextGen) and expanded and updated the NOAA Consolidated Observations Requirements List (CORL) for Aviation (CT-AWX) to better inform National Weather Service investments for current and future observing systems. This paper describes the process and results of this effort. These comprehensive aviation observation requirements will now be used to conduct gap analyses for the aviation component of the Integrated Earth Observing System and to inform the investment strategies of the FAA, NASA, and NOAA that are needed to develop the observational architecture to support NextGen and other users of storm and microscale observations.

  8. Calibration of Herschel SPIRE FTS observations at different spectral resolutions

    NASA Astrophysics Data System (ADS)

    Marchili, N.; Hopwood, R.; Fulton, T.; Polehampton, E. T.; Valtchanov, I.; Zaretski, J.; Naylor, D. A.; Griffin, M. J.; Imhof, P.; Lim, T.; Lu, N.; Makiwa, G.; Pearson, C.; Spencer, L.

    2017-01-01

    The SPIRE Fourier Transform Spectrometer on-board the Herschel Space Observatory had two standard spectral resolution modes for science observations: high resolution (HR) and low resolution (LR), which could also be performed in sequence (H+LR). A comparison of the HR and LR resolution spectra taken in this sequential mode revealed a systematic discrepancy in the continuum level. Analysing the data at different stages during standard pipeline processing demonstrates that the telescope and instrument emission affect HR and H+LR observations in a systematically different way. The origin of this difference is found to lie in the variation of both the telescope and instrument response functions, while it is triggered by fast variation of the instrument temperatures. As it is not possible to trace the evolution of the response functions using housekeeping data from the instrument subsystems, the calibration cannot be corrected analytically. Therefore, an empirical correction for LR spectra has been developed, which removes the systematic noise introduced by the variation of the response functions.

  9. Bright Object Protection Considerations for M Dwarf Flare Events

    NASA Astrophysics Data System (ADS)

    Osten, R.

    2017-02-01

    We provide clear and concise guidance for Guest Observers and Contact Scientists to evaluate the health and safety of the instrument while observing M dwarfs, taking into consideration current scientific research about the frequency with which large flare events occur, and a risk tolerance level for causing an inadvertent detector shutdown due to overlight conditions from a large flare during an observation.

  10. Flare Observations

    NASA Astrophysics Data System (ADS)

    Benz, Arnold O.

    2017-12-01

    Solar flares are observed at all wavelengths from decameter radio waves to gamma-rays beyond 1 GeV. This review focuses on recent observations in EUV, soft and hard X-rays, white light, and radio waves. Space missions such as RHESSI, Yohkoh, TRACE, SOHO, and more recently Hinode and SDO have enlarged widely the observational base. They have revealed a number of surprises: Coronal sources appear before the hard X-ray emission in chromospheric footpoints, major flare acceleration sites appear to be independent of coronal mass ejections, electrons, and ions may be accelerated at different sites, there are at least 3 different magnetic topologies, and basic characteristics vary from small to large flares. Recent progress also includes improved insights into the flare energy partition, on the location(s) of energy release, tests of energy release scenarios and particle acceleration. The interplay of observations with theory is important to deduce the geometry and to disentangle the various processes involved. There is increasing evidence supporting magnetic reconnection as the basic cause. While this process has become generally accepted as the trigger, it is still controversial how it converts a considerable fraction of the energy into non-thermal particles. Flare-like processes may be responsible for large-scale restructuring of the magnetic field in the corona as well as for its heating. Large flares influence interplanetary space and substantially affect the Earth's ionosphere. Flare scenarios have slowly converged over the past decades, but every new observation still reveals major unexpected results, demonstrating that solar flares, after 150 years since their discovery, remain a complex problem of astrophysics including major unsolved questions.

  11. Observing and Understanding Arterial and Venous Circulation Differences in a Physiology Laboratory Activity

    ERIC Educational Resources Information Center

    Altermann, Caroline; Gonçalves, Rithiele; Lara, Marcus Vinícius S.; Neves, Ben-Hur S.; Mello-Carpes, Pâmela B.

    2015-01-01

    The purpose of the present article is to describe three simple practical experiments that aim to observe and discuss the anatomic and physiological functions and differences between arteries and veins as well as the alterations observed in skin blood flow in different situations. For this activity, students were divided in small groups. In each…

  12. Sex Differences in Response to an Observational Fear Conditioning Procedure

    ERIC Educational Resources Information Center

    Kelly, Megan M.; Forsyth, John P.

    2007-01-01

    The present study evaluated sex differences in observational fear conditioning using modeled ''mock'' panic attacks as an unconditioned stimulus (UCS). Fifty-nine carefully prescreened healthy undergraduate participants (30 women) underwent 3 consecutive differential conditioning phases: habituation, acquisition, and extinction. It was expected…

  13. Shear bond strength of different retainer wires and bonding adhesives in consideration of the pretreatment process.

    PubMed

    Reicheneder, Claudia; Hofrichter, Bernd; Faltermeier, Andreas; Proff, Peter; Lippold, Carsten; Kirschneck, Christian

    2014-11-28

    We aimed to compare the shear bond strength (SBS) of three different retainer wires and three different bonding adhesives in consideration of the pretreatment process of enamel surface sandblasting. 400 extracted bovine incisors were divided into 10 groups of 20 paired specimens each. 10 specimens of each group were pretreated by enamel sandblasting. The retainer wires Bond-A-Braid™, GAC-Wildcat®-Twistflex and everStick®ORTHO were bonded to the teeth with the adhesives Transbond™-LR, Tetric-EvoFlow™ and Stick®FLOW and then debonded measuring the SBS. While sandblasting generally increased SBS for all tested combinations, the retainer wires bonded with Transbond™-LR showed the highest SBS both with and without prior sandblasting. Significantly lower SBS were found for Tetric-EvoFlow™ that were comparable to those for everStick®ORTHO. Pretreatment of enamel surfaces by sandblasting increased the SBS of all retainer-wires. Transbond™-LR showed the best results compared to Tetric-EvoFlow™ and everStick®ORTHO, while all combinations used provided sufficient bonding strengths for clinical use.

  14. Seeing the same thing differently: mechanisms that contribute to assessor differences in directly-observed performance assessments.

    PubMed

    Yeates, Peter; O'Neill, Paul; Mann, Karen; Eva, Kevin

    2013-08-01

    Assessors' scores in performance assessments are known to be highly variable. Attempted improvements through training or rating format have achieved minimal gains. The mechanisms that contribute to variability in assessors' scoring remain unclear. This study investigated these mechanisms. We used a qualitative approach to study assessors' judgements whilst they observed common simulated videoed performances of junior doctors obtaining clinical histories. Assessors commented concurrently and retrospectively on performances, provided scores and follow-up interviews. Data were analysed using principles of grounded theory. We developed three themes that help to explain how variability arises: Differential Salience-assessors paid attention to (or valued) different aspects of the performances to different degrees; Criterion Uncertainty-assessors' criteria were differently constructed, uncertain, and were influenced by recent exemplars; Information Integration-assessors described the valence of their comments in their own unique narrative terms, usually forming global impressions. Our results (whilst not precluding the operation of established biases) describe mechanisms by which assessors' judgements become meaningfully-different or unique. Our results have theoretical relevance to understanding the formative educational messages that performance assessments provide. They give insight relevant to assessor training, assessors' ability to be observationally "objective" and to the educational value of narrative comments (in contrast to numerical ratings).

  15. [Gender specific differences in coping with colon cancer--empirical findings with special consideration of religious coping].

    PubMed

    Murken, S; Namini, S; Gross, S; Körber, J

    2010-04-01

    The present study investigated whether women and men differ with regard to non-religious and religious coping with cancer, here: colon cancer--a question on which only little research has been done so far. 341 patients filled in a questionnaire during inpatient oncological rehabilitation. Statistical analyses showed that women reported higher mental strain than men. They used more bagatellization and wishful thinking, more depressive and less active problem-oriented coping strategies. A higher use of religious coping among women was to a high degree associated with their generally stronger religiosity. Correlations between coping strategies and measures of mental health indicated commonalities and differences. In particular, a positive correlation between active problem-oriented coping and mental health was found for men but not for women. In accordance with women's higher religiosity, the data indicate a stronger correlation between religious coping and adaptation among women than among men. The results suggest that gender differences and religiosity can be relevant in the context of treatment but that their significance must not be overinterpreted. In terms of patient orientation they speak for the necessity to individually assess the need for support, also with regard to the consideration of religiosity in the treatment process. Georg Thieme Verlag KG Stuttgart.New York.

  16. Operational Considerations in the Organization of Indian Business Enterprises.

    ERIC Educational Resources Information Center

    Brudevold, Daniel L.; And Others

    1982-01-01

    To provide Tribal Councils and enterprises with fundamental guidelines to organize and administer enterprises as profit-seeking businesses, the paper is presented in four sections: differences in basic purposes (business vs. government); organizational considerations; fiscal management considerations; and guidelines for organizing and establishing…

  17. Practical considerations for measuring hydrogen concentrations in groundwater

    USGS Publications Warehouse

    Chapelle, F.H.; Vroblesky, D.A.; Woodward, J.C.; Lovley, D.R.

    1997-01-01

    Several practical considerations for measuring concentrations of dissolved molecular hydrogen (H2) in groundwater including 1 sampling methods 2 pumping methods and (3) effects of well casing materials were evaluated. Three different sampling methodologies (a downhole sampler, a gas- stripping method, and a diffusion sampler) were compared. The downhole sampler and gas-stripping methods gave similar results when applied to the same wells, the other hand, appeared to The diffusion sampler, on overestimate H2 concentrations relative to the downhole sampler. Of these methods, the gas-stripping method is better suited to field conditions because it is faster (~ 30 min for a single analysis as opposed to 2 h for the downhole sampler or 8 h for the diffusion sampler), the analysis is easier (less sample manipulation is required), and the data computations are more straightforward (H2 concentrations need not be corrected for water sample volume). Measurement of H2 using the gas-stripping method can be affected by different pumping equipment. Peristaltic, piston, and bladder pumps all gave similar results when applied to water produced from the same well. It was observed, however, that peristaltic-pumped water (which draws water under a negative pressure) enhanced the gas-stripping process and equilibrated slightly faster than either piston or bladder pumps (which push water under a positive pressure). A direct current(dc) electrically driven submersible pump was observed to produce H2 and was not suitable for measuring H2 in groundwater. Measurements from two field sites indicate that iron or steel well casings, produce H2, which masks H2 concentrations in groundwater. PVC-cased wells or wells cased with other materials that do not produce H2 are necessary for measuring H2 concentrations in groundwater.Several practical considerations for measuring concentrations of dissolved molecular hydrogen in groundwater including sampling methods, pumping methods, and effects of

  18. Observing with HST V: Improvements to the Scheduling of HST Parallel Observations

    NASA Astrophysics Data System (ADS)

    Taylor, D. K.; Vanorsow, D.; Lucks, M.; Henry, R.; Ratnatunga, K.; Patterson, A.

    1994-12-01

    Recent improvements to the Hubble Space Telescope (HST) ground system have significantly increased the frequency of pure parallel observations, i.e. the simultaneous use of multiple HST instruments by different observers. Opportunities for parallel observations are limited by a variety of timing, hardware, and scientific constraints. Formerly, such opportunities were heuristically predicted prior to the construction of the primary schedule (or calendar), and lack of complete information resulted in high rates of scheduling failures and missed opportunities. In the current process the search for parallel opportunities is delayed until the primary schedule is complete, at which point new software tools are employed to identify places where parallel observations are supported. The result has been a considerable increase in parallel throughput. A new technique, known as ``parallel crafting,'' is currently under development to streamline further the parallel scheduling process. This radically new method will replace the standard exposure logsheet with a set of abstract rules from which observation parameters will be constructed ``on the fly'' to best match the constraints of the parallel opportunity. Currently, parallel observers must specify a huge (and highly redundant) set of exposure types in order to cover all possible types of parallel opportunities. Crafting rules permit the observer to express timing, filter, and splitting preferences in a far more succinct manner. The issue of coordinated parallel observations (same PI using different instruments simultaneously), long a troublesome aspect of the ground system, is also being addressed. For Cycle 5, the Phase II Proposal Instructions now have an exposure-level PAR WITH special requirement. While only the primary's alignment will be scheduled on the calendar, new commanding will provide for parallel exposures with both instruments.

  19. Time Delays of Blazar Flares Observed at Different Wavebands

    NASA Technical Reports Server (NTRS)

    Marscher, Alan P.

    2000-01-01

    Correlated variability at different frequencies can probe the structure and physics of the jet of a blazar on size scales much smaller than can be resolved by telescopes and interferometers. I discuss some observations of frequency dependent time lags and how these place constraints on models for the nonthermal emission in blazars. The time lags can be either positive (high frequency variations leading those at lower frequencies) or negative, while simultaneous flares are also possible.

  20. Bright Object Protection (BOP) Considerations for M Dwarf Flare Events

    NASA Astrophysics Data System (ADS)

    Osten, R.

    2017-02-01

    We provide clear and concise guidance for Guest Observers and Contact Scientists to evaluate the health and safety of the instrument when observing M dwarfs, taking into consideration current scientific research about the frequency with which large flare events occur, and a risk tolerance level for causing an inadvertent detector shutdown due to overlight conditions from a large flare during an observation.

  1. Simple and multiple linear regression: sample size considerations.

    PubMed

    Hanley, James A

    2016-11-01

    The suggested "two subjects per variable" (2SPV) rule of thumb in the Austin and Steyerberg article is a chance to bring out some long-established and quite intuitive sample size considerations for both simple and multiple linear regression. This article distinguishes two of the major uses of regression models that imply very different sample size considerations, neither served well by the 2SPV rule. The first is etiological research, which contrasts mean Y levels at differing "exposure" (X) values and thus tends to focus on a single regression coefficient, possibly adjusted for confounders. The second research genre guides clinical practice. It addresses Y levels for individuals with different covariate patterns or "profiles." It focuses on the profile-specific (mean) Y levels themselves, estimating them via linear compounds of regression coefficients and covariates. By drawing on long-established closed-form variance formulae that lie beneath the standard errors in multiple regression, and by rearranging them for heuristic purposes, one arrives at quite intuitive sample size considerations for both research genres. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. Gossiping to the Top: Observed Differences in Popular Adolescents' Gossip

    ERIC Educational Resources Information Center

    Wargo Aikins, Julie; Collibee, Charlene; Cunningham, Jessica

    2017-01-01

    Despite its omnipresence, quantitative research examining both the nature and the function of adolescent gossip has been limited. The present study aimed to address this limitation in the literature by examining the nature and function of adolescent gossip; in particular, it aimed to explore observed differences between the gossip of those popular…

  3. Methodological considerations for observational coding of eating and feeding behaviors in children and their families.

    PubMed

    Pesch, Megan H; Lumeng, Julie C

    2017-12-15

    Behavioral coding of videotaped eating and feeding interactions can provide researchers with rich observational data and unique insights into eating behaviors, food intake, food selection as well as interpersonal and mealtime dynamics of children and their families. Unlike self-report measures of eating and feeding practices, the coding of videotaped eating and feeding behaviors can allow for the quantitative and qualitative examinations of behaviors and practices that participants may not self-report. While this methodology is increasingly more common, behavioral coding protocols and methodology are not widely shared in the literature. This has important implications for validity and reliability of coding schemes across settings. Additional guidance on how to design, implement, code and analyze videotaped eating and feeding behaviors could contribute to advancing the science of behavioral nutrition. The objectives of this narrative review are to review methodology for the design, operationalization, and coding of videotaped behavioral eating and feeding data in children and their families, and to highlight best practices. When capturing eating and feeding behaviors through analysis of videotapes, it is important for the study and coding to be hypothesis driven. Study design considerations include how to best capture the target behaviors through selection of a controlled experimental laboratory environment versus home mealtime, duration of video recording, number of observations to achieve reliability across eating episodes, as well as technical issues in video recording and sound quality. Study design must also take into account plans for coding the target behaviors, which may include behavior frequency, duration, categorization or qualitative descriptors. Coding scheme creation and refinement occur through an iterative process. Reliability between coders can be challenging to achieve but is paramount to the scientific rigor of the methodology. Analysis approach

  4. Some observations from behavioral economics for consideration in promoting money management among those with substance use disorders.

    PubMed

    Chivers, Laura L; Higgins, Stephen T

    2012-01-01

    Behavioral economics research has revealed systematic biases in decision making that merit consideration in efforts to promote money management skills among those with substance use disorders (SUDs). The objective of this article was to briefly review the literature on five of those biases (i.e., hyperbolic delay discounting, defaults and preference for the status quo, loss aversion, mental accounting, and failure to account for opportunity cost) that may have particular relevance to the topic of money management. Selected studies are reviewed to illustrate these biases and how they may relate to efforts to promote money management skills among those with substance use disorders. Studies were identified by searching PubMed using the terms "behavioral economics" and "substance use disorders", reviewing bibliographies of published articles, and discussions with colleagues. Only one of these biases (i.e., hyperbolic delay discounting) has been investigated extensively among those with SUDs. Indeed, it has been found to be sufficiently prevalent among those with SUDs to be considered as a potential risk factor for those disorders and certainly merits careful consideration in efforts to improve money management skills in that population. There has been relatively little empirical research reported regarding the other biases among those with SUDs, although they appear to be sufficiently fundamental to human behavior and relevant to the topic of money management (e.g., loss aversion) to also merit consideration. There is precedent of effective leveraging of behavioral economics principles in treatment development for SUDs (e.g., contingency management), including at least one intervention that explicitly focuses on money management (i.e., advisor-teller money management therapy). The consideration of the systematic biases in human decision making that have been revealed in behavioral economics research has the potential to enhance efforts to devise effective strategies

  5. Spatial, temporal and geographic considerations of the problem of rock varnish diagenesis

    NASA Astrophysics Data System (ADS)

    Dorn, Ronald I.; Krinsley, David

    2011-07-01

    The rock varnish literature hosts an abundance of prima facie contradictory empirical data. Past and perhaps future empirical contradictions, however, can be resolved by theoretical considerations of different spatial and temporal scales of varnish diagenesis, as well as the geomorphic position of different types of varnishes. For example, twentieth-century contamination by lead and other heavy metals has led to claims of accumulation rates in the last century far more rapid than prior published empirical studies. A consideration of spatial scales resolves this contradiction; nanoscale processes allow migration of lead into varnish deposited well before the twentieth century time of heavy metal pollution. Evidence of nanometer-scale disequilibrium in three samples led to claims that varnish cannot be used in paleoclimatic research; these data rest in contrast to replicable patterns in varnish deposition observed by Dr. Tanzhuo Liu and others in over ten thousand micro-sedimentary basins. This contraction can be resolved by understanding that the types of varnishes studied differ and that processes differ substantially between the nanoscale and the micron scale. A lack of evidence of Mn-oxidizers in genetic analyses contrasts with culturing studies and in situ evidence of Mn-enhancement by bacteria. This contradiction has a likely resolution in vastly different temporal scales; DNA material analyzed may be no older than 200 years, but in situ fossilized remains of bacteria may be preserved for thousands of years recording palaeoecological conditions favoring growth of Mn-enhancing bacteria.

  6. Prospective clinical observational study evaluating gender-associated differences of preoperative pain intensity.

    PubMed

    Tafelski, Sascha; Kerper, Léonie F; Salz, Anna-Lena; Spies, Claudia; Reuter, Eva; Nachtigall, Irit; Schäfer, Michael; Krannich, Alexander; Krampe, Henning

    2016-07-01

    Previous studies reported conflicting results concerning different pain perceptions of men and women. Recent research found higher pain levels in men after major surgery, contrasted by women after minor procedures. This trial investigates differences in self-reported preoperative pain intensity between genders before surgery.Patients were enrolled in 2011 and 2012 presenting for preoperative evaluation at the anesthesiological assessment clinic at Charité University hospital. Out of 5102 patients completing a computer-assisted self-assessment, 3042 surgical patients with any preoperative pain were included into this prospective observational clinical study. Preoperative pain intensity (0-100 VAS, visual analog scale) was evaluated integrating psychological cofactors into analysis.Women reported higher preoperative pain intensity than men with median VAS scores of 30 (25th-75th percentiles: 10-52) versus 21 (10-46) (P < 0.001). Adjusted multiple regression analysis showed that female gender remained statistically significantly associated with higher pain intensity (P < 0.001). Gender differences were consistent across several subgroups especially with varying patterns in elderly. Women scheduled for minor and moderate surgical procedures showed largest differences in overall pain compared to men.This large clinical study observed significantly higher preoperative pain intensity in female surgical patients. This gender difference was larger in the elderly potentially contradicting the current hypothesis of a primary sex-hormone derived effect. The observed variability in specific patient subgroups may help to explain heterogeneous findings of previous studies.

  7. Difference Image Analysis of Defocused Observations With CSTAR

    NASA Astrophysics Data System (ADS)

    Oelkers, Ryan J.; Macri, Lucas M.; Wang, Lifan; Ashley, Michael C. B.; Cui, Xiangqun; Feng, Long-Long; Gong, Xuefei; Lawrence, Jon S.; Qiang, Liu; Luong-Van, Daniel; Pennypacker, Carl R.; Yang, Huigen; Yuan, Xiangyan; York, Donald G.; Zhou, Xu; Zhu, Zhenxi

    2015-02-01

    The Chinese Small Telescope ARray carried out high-cadence time-series observations of 27 square degrees centered on the South Celestial Pole during the Antarctic winter seasons of 2008-2010. Aperture photometry of the 2008 and 2010 i-band images resulted in the discovery of over 200 variable stars. Yearly servicing left the array defocused for the 2009 winter season, during which the system also suffered from intermittent frosting and power failures. Despite these technical issues, nearly 800,000 useful images were obtained using g, r, and clear filters. We developed a combination of difference imaging and aperture photometry to compensate for the highly crowded, blended, and defocused frames. We present details of this approach, which may be useful for the analysis of time-series data from other small-aperture telescopes regardless of their image quality. Using this approach, we were able to recover 68 previously known variables and detected variability in 37 additional objects. We also have determined the observing statistics for Dome A during the 2009 winter season; we find the extinction due to clouds to be less than 0.1 and 0.4 mag for 40% and 63% of the dark time, respectively.

  8. Consideration Sets and Their Role in Modelling Doctor Recommendations About Contraceptives.

    PubMed

    Fiebig, Denzil G; Viney, Rosalie; Knox, Stephanie; Haas, Marion; Street, Deborah J; Hole, Arne R; Weisberg, Edith; Bateson, Deborah

    2017-01-01

    Decisions about prescribed contraception are typically the result of a consultation between a woman and her doctor. In order to better understand contraceptive choice within this environment, stated preference methods are utilized to ask doctors about what contraceptive options they would discuss with different types of women. The role of doctors is to confine their discussion to a subset of products that best match their patient. This subset of options forms the consideration set from which the ultimate recommendation is made. Given the existence of consideration sets we address the issue of how to model appropriately the ultimate recommendations. The estimated models enable us to characterize doctor recommendations and how they vary with patient attributes and to highlight where recommendations are clear and when they are uncertain. The results also indicate systematic variation in recommendations across different types of doctors, and in particular we observe that some doctors are reluctant to embrace new products and instead recommend those that are more familiar. Such effects are one possible explanation for the relatively low uptake of more cost effective longer acting reversible contraceptives and indicate that further education and training of doctors may be warranted. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

  9. Three-dimensional dosimetric considerations from different point A definitions in cervical cancer low-dose-rate brachytherapy

    PubMed Central

    Chen, Ting; Kim, Leonard H.; Nelson, Carl; Gabel, Molly; Narra, Venkat; Haffty, Bruce; Yue, Ning J.

    2013-01-01

    Purpose To investigate the dosimetric difference due to the different point A definitions in cervical cancer low-dose-rate (LDR) intracavitary brachytherapy. Material and methods Twenty CT-based LDR brachytherapy plans of 11 cervical patients were retrospectively reviewed. Two plans with point As following the modified Manchester system which defines point A being 2 cm superior to the cervical os along the tandem and 2 cm lateral (Aos), and the American Brachytherapy Society (ABS) guideline definition in which the point A is 2 cm superior to the vaginal fornices instead of os (Aovoid) were generated. Using the same source strength, two plans prescribed the same dose to Aos and Aovoid. Dosimetric differences between plans including point A dose rate, treatment volume encompassed by the prescription isodose line (TV), and dose rate of 2 cc of the rectum and bladder to the prescription dose were measured. Results On average Aovoid was 8.9 mm superior to Aos along the tandem direction with a standard deviation of 5.4 mm. With the same source strength and arrangement, Aos dose rate was 19% higher than Aovoid dose rate. The average TV(Aovoid) was 118.0 cc, which was 30% more than the average TV(Aos) of 93.0 cc. D2cc/D(Aprescribe) increased from 51% to 60% for rectum, and increased from 89% and 106% for bladder, if the prescription point changed from Aos to Aovoid. Conclusions Different point A definitions lead to significant dose differences. Careful consideration should be given when changing practice from one point A definition to another, to ensure dosimetric and clinical equivalency from the previous clinical experiences. PMID:24474971

  10. Biological Differences and Social Equality: A Revolutionary Idea.

    ERIC Educational Resources Information Center

    Vaughter, Reesa M.

    Barriers to equitable scientific consideration of biological differences are being noticed by many scholars considering social equity. Many have observed the alliance and contamination of the biological and social sciences, reinforcing cultural biases. The uncritical acceptance and application of bio-medical models also produce inadequate methods…

  11. Considerations for safe glucocorticoid therapy

    PubMed

    2018-06-01

    Synthetic glucocorticoids have innumerable therapeutic applications and are frequently used in medical practice. Changes in the wide variety of synthetic molecules and the different routes of administration cause differences in anti-inflammatory action, therapeutic action and mineralocorticoid effects. Endocrinologists are generally consulted to evaluate the gradual decline in treatment, rather than to indicate it. We present general information and practical advice to the pediatrician to minimize the adverse effects and considerations to be taken into account for the suspension of treatment.

  12. Precision of natural satellite ephemerides from observations of different types

    NASA Astrophysics Data System (ADS)

    Emelyanov, N. V.

    2017-08-01

    Currently, various types of observations of natural planetary satellites are used to refine their ephemerides. A new type of measurement - determining the instants of apparent satellite encounters - has recently been proposed by Morgado and co-workers. The problem that arises is which type of measurement to choose in order to obtain an ephemeris precision that is as high as possible. The answer can be obtained only by modelling the entire process: observations, obtaining the measured values, refining the satellite motion parameters, and generating the ephemeris. The explicit dependence of the ephemeris precision on observational accuracy as well as on the type of observations is unknown. In this paper, such a dependence is investigated using the Monte Carlo statistical method. The relationship between the ephemeris precision for different types of observations is then assessed. The possibility of using the instants of apparent satellite encounters to obtain an ephemeris is investigated. A method is proposed that can be used to fit the satellite orbital parameters to this type of measurement. It is shown that, in the absence of systematic scale errors in the CCD frame, the use of the instants of apparent encounters leads to less precise ephemerides. However, in the presence of significant scale errors, which is often the case, this type of measurement becomes effective because the instants of apparent satellite encounters do not depend on scale errors.

  13. Shear weakening for different lithologies observed at different saturation stages

    NASA Astrophysics Data System (ADS)

    Diethart-Jauk, Elisabeth; Gegenhuber, Nina

    2018-01-01

    For this study, samples from different lithologies ("Leitha"-limestone, "Dachstein"-limestone, "Haupt"-dolomite, "Bunt"-sandstone, Grey Berea sandstone, granite, quartzite and basalt) were selected. Samples were dried at 70 °C, respectively 105 °C and were saturated with brine. Mass, porosity, permeability, compressional and shear wave velocity were determined from dry and brine saturated samples at laboratory conditions, based on an individual measurement program. Shear modulus was calculated to find out, if shear weakening exists for the dataset. Shear weakening means that shear modulus of dry samples is higher than of saturated samples, but it is assumed that shear modulus is unaffected by saturation. "Dachstein"-limestone and basalt show shear weakening, quartzite samples show both weakening and hardening. Granite samples are affected by temperature, after drying with 105 °C no change can be observed anymore. "Bunt"-sandstone samples show a change in the shear modulus in a small extent, although they may contain clay minerals. The other lithologies show no effect. Explanations for carbonate samples can be the complicated pore structure, for basalt it could be that weathering creates clay minerals which are known as causes for a change of the shear modulus. Fluid viscosity can also be an important factor.

  14. Some Observations from Behavioral Economics for Consideration in Promoting Money Management among Those with Substance Use Disorders

    PubMed Central

    Chivers, Laura L.; Higgins, Stephen T.

    2016-01-01

    Background Behavioral economics research has revealed systematic biases in decision making that merit consideration in efforts to promote money management skills among those with substance use disorders (SUDs). Objectives The objective of this article was to briefly review the literature on five of those biases (i.e., hyperbolic delay discounting, defaults and preference for the status quo, loss aversion, mental accounting, and failure to account for opportunity cost) that may have particular relevance to the topic of money management. Methods Selected studies are reviewed to illustrate these biases and how they may relate to efforts to promote money management skills among those with substance use disorders. Studies were identified by searching PubMed using the terms “behavioral economics” and “substance use disorders”, reviewing bibliographies of published articles, and discussions with colleagues. Results Only one of these biases (i.e., hyperbolic delay discounting) has been investigated extensively among those with SUDs. Indeed, it has been found to be sufficiently prevalent among those with SUDs to be considered as a potential risk factor for those disorders and certainly merits careful consideration in efforts to improve money management skills in that population. There has been relatively little empirical research reported regarding the other biases among those with SUDs, although they appear to be sufficiently fundamental to human behavior and relevant to the topic of money management (e.g., loss aversion) to also merit consideration. There is precedent of effective leveraging of behavioral economics principles in treatment development for SUDs (e.g., contingency management), including at least one intervention that explicitly focuses on money management (i.e., advisor–teller money management therapy). Conclusions and Scientific Significance The consideration of the systematic biases in human decision making that have been revealed in behavioral

  15. Understanding differences in results from literature-based and individual patient meta-analyses: an example from meta-analyses of observational data.

    PubMed

    Poppe, Katrina K; Doughty, Robert N; Yu, Cheuk-Man; Quintana, Miguel; Møller, Jacob E; Klein, Allan L; Gamble, Greg D; Dini, Frank L; Whalley, Gillian A

    2011-04-14

    Meta-analyses are increasingly used to summarise observational data however a literature meta-analysis (LMA) may give different results to the corresponding individual patient meta-analysis (IPMA). This study compares the published results of equivalent LMAs and IPMAs, highlighting factors that can affect the results and therefore impact on clinical interpretation of meta-analyses. Univariate results from published meta-analyses of prospective observational outcome data were compared, as were the number of studies, patients and length of follow-up. The absolute difference in survival was calculated. The association between severe diastolic dysfunction (RFP) and death post acute myocardial infarction (AMI) and in chronic heart failure (HF) were used as clinical examples. The IPMA hazard ratio was lower that the LMA odds ratio: AMI hazard ratio 2.67 (95% confidence interval 2.23 to 3.20), odds ratio 4.10 (3.38 to 4.99); HF hazard ratio 2.42 (2.06 to 2.83), odds ratio 4.36 (3.60 to 5.04). The IPMAs contained most of the studies from the LMAs as well as additional unpublished data, and a longer length of follow-up was available in the IPMAs (AMI 3.7 vs 2.6 yr, HF 4.0 vs 1.5 yr). Restricting analysis to the same studies in both the LMA and IPMA resulted in a similar difference in effect sizes between methods to those found in the published analyses. The result of a meta-analysis is affected by whether study level or individual patient data have been used, and the variant of analysis that is required. Awareness and consideration of these factors is important for clinical interpretation of meta-analyses. Copyright © 2009 Elsevier B.V. All rights reserved.

  16. Transitional behavior of different energy protons based on Van Allen Probes observations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yue, Chao; Bortnik, Jacob; Chen, Lunjin

    Understanding the dynamical behavior of ~1 eV to 50 keV ions and identifying the energies at which the morphologies transit are important in that they involve the relative intensities and distributions of the large-scale electric and magnetic fields, the outflow, and recombination rates. However, there have been only few direct observational investigations of the transition in drift behaviors of different energy ions before the Van Allen Probes era. In this paper, we statistically analyze ~1 eV to 50 keV hydrogen (H +) differential flux distributions near geomagnetic equator by using Van Allen Probes observations to investigate the H + dynamicsmore » under the regulation of large-scale electric and magnetic fields. Our survey clearly indicates three types of H + behaviors within different energy ranges, which is consistent with previous theory predictions. Finally, using simple electric and magnetic field models in UBK coordinates, we have further constrained the source regions of different energy ions and their drift directions.« less

  17. Transitional behavior of different energy protons based on Van Allen Probes observations

    DOE PAGES

    Yue, Chao; Bortnik, Jacob; Chen, Lunjin; ...

    2016-12-09

    Understanding the dynamical behavior of ~1 eV to 50 keV ions and identifying the energies at which the morphologies transit are important in that they involve the relative intensities and distributions of the large-scale electric and magnetic fields, the outflow, and recombination rates. However, there have been only few direct observational investigations of the transition in drift behaviors of different energy ions before the Van Allen Probes era. In this paper, we statistically analyze ~1 eV to 50 keV hydrogen (H +) differential flux distributions near geomagnetic equator by using Van Allen Probes observations to investigate the H + dynamicsmore » under the regulation of large-scale electric and magnetic fields. Our survey clearly indicates three types of H + behaviors within different energy ranges, which is consistent with previous theory predictions. Finally, using simple electric and magnetic field models in UBK coordinates, we have further constrained the source regions of different energy ions and their drift directions.« less

  18. Supplier Relationship Management: Models, Considerations and Implications for DOD

    DTIC Science & Technology

    2003-01-01

    AY 2002-2003 SUPPLIER RELATIONSHIP MANAGEMENT : MODELS, CONSIDERATIONS AND IMPLICATIONS FOR DOD STRATEGIC SUPPLY INDUSTRY STUDY COURSE COLONEL TOM...REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Supplier Relationship Management : Models, Considerations and Implications for DOD...nature of the market or industry drive differences in supplier relationships ? This paper begins by defining supplier relationship management (SRM) and why

  19. Modeling of unit operating considerations in generating-capacity reliability evaluation. Volume 1. Mathematical models, computing methods, and results. Final report. [GENESIS, OPCON and OPPLAN

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Patton, A.D.; Ayoub, A.K.; Singh, C.

    1982-07-01

    Existing methods for generating capacity reliability evaluation do not explicitly recognize a number of operating considerations which may have important effects in system reliability performance. Thus, current methods may yield estimates of system reliability which differ appreciably from actual observed reliability. Further, current methods offer no means of accurately studying or evaluating alternatives which may differ in one or more operating considerations. Operating considerations which are considered to be important in generating capacity reliability evaluation include: unit duty cycles as influenced by load cycle shape, reliability performance of other units, unit commitment policy, and operating reserve policy; unit start-up failuresmore » distinct from unit running failures; unit start-up times; and unit outage postponability and the management of postponable outages. A detailed Monte Carlo simulation computer model called GENESIS and two analytical models called OPCON and OPPLAN have been developed which are capable of incorporating the effects of many operating considerations including those noted above. These computer models have been used to study a variety of actual and synthetic systems and are available from EPRI. The new models are shown to produce system reliability indices which differ appreciably from index values computed using traditional models which do not recognize operating considerations.« less

  20. Observing the Global Water Cycle from Space

    NASA Technical Reports Server (NTRS)

    Hildebrand, P. H.

    2004-01-01

    This paper presents an approach to measuring all major components of the water cycle from space. Key elements of the global water cycle are discussed in terms of the storage of water-in the ocean, air, cloud and precipitation, in soil, ground water, snow and ice, and in lakes and rivers, and in terms of the global fluxes of water between these reservoirs. Approaches to measuring or otherwise evaluating the global water cycle are presented, and the limitations on known accuracy for many components of the water cycle are discussed, as are the characteristic spatial and temporal scales of the different water cycle components. Using these observational requirements for a global water cycle observing system, an approach to measuring the global water cycle from space is developed. The capabilities of various active and passive microwave instruments are discussed, as is the potential of supporting measurements from other sources. Examples of space observational systems, including TRMM/GPM precipitation measurement, cloud radars, soil moisture, sea surface salinity, temperature and humidity profiling, other measurement approaches and assimilation of the microwave and other data into interpretative computer models are discussed to develop the observational possibilities. The selection of orbits is then addressed, for orbit selection and antenna size/beamwidth considerations determine the sampling characteristics for satellite measurement systems. These considerations dictate a particular set of measurement possibilities, which are then matched to the observational sampling requirements based on the science. The results define a network of satellite instrumentation systems, many in low Earth orbit, a few in geostationary orbit, and all tied together through a sampling network that feeds the observations into a data-assimilative computer model.

  1. Management of Gynecomastia in Patients With Different Body Types: Considerations on 312 Consecutive Treated Cases.

    PubMed

    Innocenti, Alessandro; Melita, Dario; Mori, Francesco; Ciancio, Francesco; Innocenti, Marco

    2017-05-01

    Gynecomastia is a common finding in male subjects which incidence varies widely in the world population. In adolescents, it is frequently temporary but, if it becomes persistent, it generates considerable embarrassment, inducing the patients to seek surgical consultation. Even in patients with good body contour, gynecomastia creates even greater distress considering the special attention given by these subjects to their physical appearance. The authors present their experience in the treatment of gynecomastia comparing different body types of patients with the aim to investigate dissimilar expectations, needs and surgical outcomes thus optimizing the management of the pathological condition, achieving high levels of agreement and reducing unsatisfied patients arising from cosmetic surgery. Between January 2007 and January 2015, 312 selected patients have been treated surgically for gynecomastia. Patients were grouped according to their physical aspect: 97 were classified as high muscle mass body type (group A), 106 as normal (group B) and 109 as overweight patients (group C). All of them were adults ranging in age between 18 and 52 years. Follow-up ranged from 12 to 60 months. In all cases, an excision of the gland in the form of a subcutaneous mastectomy was performed; the most common surgical access was in the inferior part of the areola. No breast cancers were found at the histological examinations. Also, no skin or areola necrosis have been referred, and no recurrence of gynecomastia disorder has been reported. Six cases of seroma (limited to the fatty gynecomastia) and 3 cases of hematomas (requiring immediate surgical revision) were found. Although the patients in group B resulted more distressed by the disorder, higher levels of postoperative satisfaction were recorded in this group. The study demonstrates the importance of the different management of the same disorder according to the different patients' expectations, related to the different body type. Our

  2. Novel jet observables from machine learning

    NASA Astrophysics Data System (ADS)

    Datta, Kaustuv; Larkoski, Andrew J.

    2018-03-01

    Previous studies have demonstrated the utility and applicability of machine learning techniques to jet physics. In this paper, we construct new observables for the discrimination of jets from different originating particles exclusively from information identified by the machine. The approach we propose is to first organize information in the jet by resolved phase space and determine the effective N -body phase space at which discrimination power saturates. This then allows for the construction of a discrimination observable from the N -body phase space coordinates. A general form of this observable can be expressed with numerous parameters that are chosen so that the observable maximizes the signal vs. background likelihood. Here, we illustrate this technique applied to discrimination of H\\to b\\overline{b} decays from massive g\\to b\\overline{b} splittings. We show that for a simple parametrization, we can construct an observable that has discrimination power comparable to, or better than, widely-used observables motivated from theory considerations. For the case of jets on which modified mass-drop tagger grooming is applied, the observable that the machine learns is essentially the angle of the dominant gluon emission off of the b\\overline{b} pair.

  3. In situ Observations of Heliospheric Current Sheets Evolution

    NASA Astrophysics Data System (ADS)

    Liu, Yong; Peng, Jun; Huang, Jia; Klecker, Berndt

    2017-04-01

    We investigate the Heliospheric current sheet observation time difference of the spacecraft using the STEREO, ACE and WIND data. The observations are first compared to a simple theory in which the time difference is only determined by the radial and longitudinal separation between the spacecraft. The predictions fit well with the observations except for a few events. Then the time delay caused by the latitudinal separation is taken in consideration. The latitude of each spacecraft is calculated based on the PFSS model assuming that heliospheric current sheets propagate at the solar wind speed without changing their shapes from the origin to spacecraft near 1AU. However, including the latitudinal effects does not improve the prediction, possibly because that the PFSS model may not locate the current sheets accurately enough. A new latitudinal delay is predicted based on the time delay using the observations on ACE data. The new method improved the prediction on the time lag between spacecraft; however, further study is needed to predict the location of the heliospheric current sheet more accurately.

  4. Considerations of sex and gender differences in preclinical and clinical trials.

    PubMed

    Raz, Limor; Miller, Virginia M

    2012-01-01

    Women continue to be underrepresented in clinical trials, particularly in Phases I and II of experimental drug studies in spite of legislative guidelines in the USA, Canada, the European Union, Australia, and Japan requiring the inclusion of women in clinical trials. As such, women remain a vulnerable population subject to the adverse effects of pharmacological therapies. Thus, women experience higher rates of adverse drug reactions than do men and for women of reproductive age or who may be pregnant, therapeutic options may be limited. This chapter provides a brief history of inclusion of sex and gender as variables in clinical trials, summarizes governmental legislation for consideration of sex and gender in clinical trials and provides specific examples of drugs which have been withdrawn from the market because of side effects in women. Additional information related to sex and gender in preclinical testing, trial design, challenges to recruitment of women for clinical trials and statistical methods for analysis of data also is considered.

  5. Formulary considerations in selection of beta-blockers.

    PubMed

    Yedinak, K C

    1993-08-01

    Selection of beta-adrenergic blockers for formulary addition can be a difficult task, especially with the increasing availability of new beta-blockers, as well as the numerous differences in pharmacodynamic and pharmacokinetic properties of currently available agents. Nevertheless, appropriate evaluation of the important characteristics of beta-blockers should allow selection of the most cost-effective agents for formulary addition. Most importantly, differences in efficacy, product formulation and cost should be carefully considered when making formulary decisions. Notably, evidence from clinical trials indicates differences in efficacy among beta-blockers for post-myocardial infarction prophylaxis, situational anxiety, essential tremor, thyrotoxicosis, migraine prophylaxis and prevention of bleeding associated with oesophageal varices. For many clinical situations, it is also important to select an effective agent that is available in both an oral and intravenous formulation, especially for cardioprotection after acute myocardial infarction and for use in supraventricular arrhythmias. In addition, availability of sustained release products and generic formulations should be considered for their potential to increase compliance and decrease cost, respectively. Comparative drug costs, as well as costs associated with decreased compliance, should also be carefully evaluated. Differences in beta-receptor selectivity, duration of action and presence of intrinsic sympathomimetic activity (ISA) are also important considerations in the selection of beta-blockers for formulary consideration. Although degree of selectivity is relative, beta 1-selective agents may be less likely to induce bronchospasm in patients with chronic obstructive pulmonary disease (COPD) and may be less likely to affect glucose homeostasis in patients with diabetes mellitus. Duration of action of a beta-blocker is an important consideration for evaluation of efficacy throughout the recommended

  6. Observing and understanding arterial and venous circulation differences in a physiology laboratory activity.

    PubMed

    Altermann, Caroline; Gonçalves, Rithiele; Lara, Marcus Vinícius S; Neves, Ben-Hur S; Mello-Carpes, Pâmela B

    2015-12-01

    The purpose of the present article is to describe three simple practical experiments that aim to observe and discuss the anatomic and physiological functions and differences between arteries and veins as well as the alterations observed in skin blood flow in different situations. For this activity, students were divided in small groups. In each group, a volunteer is recruited for each experiment. The experiments only require a sphygmomanometer, rubber bands, and a clock and allow students to develop a hypothesis to explain the different responses to the interruption of arterial and venous blood flow. At the end, students prepare a short report, and the results are discussed. This activity allows students to perceive the presence of physiology in their daily lives and helps them to understand the concepts related to the cardiovascular system and hemodynamics. Copyright © 2015 The American Physiological Society.

  7. Different results on tetrachorical correlations in Mplus and Stata--Stata announces modified procedure.

    PubMed

    Günther, Agnes; Höfler, Michael

    2006-01-01

    To identify the structure of mental disorders in large-scale epidemiological data sets, investigators frequently use tetrachoric correlations as a first step for subsequent application of latent class and factor analytic methods. It has been possible to do this with Stata since 2005, whereas the corresponding Mplus routine has been on the market for some years. Using an identical data set we observed considerable differences between the results of the packages. This paper illustrates the differences with several examples from the Early Developmental Stages of Psychopathology Study data set, which consists of 3021 subjects, with diagnostic information assessed by the CIDI. Results reveal that tetrachoric correlations resulting from Mplus were often considerably smaller than those computed with Stata. The results were dramatically different, especially where there were few observation per cell or even empty cells. These findings were put to Mplus and Stata, whose responses clarified the discrepancies by describing the different mathematical assumptions and procedures used. Stata announced that it intended to launch a modified procedure.

  8. Identifying Heat Waves in Florida: Considerations of Missing Weather Data.

    PubMed

    Leary, Emily; Young, Linda J; DuClos, Chris; Jordan, Melissa M

    2015-01-01

    Using current climate models, regional-scale changes for Florida over the next 100 years are predicted to include warming over terrestrial areas and very likely increases in the number of high temperature extremes. No uniform definition of a heat wave exists. Most past research on heat waves has focused on evaluating the aftermath of known heat waves, with minimal consideration of missing exposure information. To identify and discuss methods of handling and imputing missing weather data and how those methods can affect identified periods of extreme heat in Florida. In addition to ignoring missing data, temporal, spatial, and spatio-temporal models are described and utilized to impute missing historical weather data from 1973 to 2012 from 43 Florida weather monitors. Calculated thresholds are used to define periods of extreme heat across Florida. Modeling of missing data and imputing missing values can affect the identified periods of extreme heat, through the missing data itself or through the computed thresholds. The differences observed are related to the amount of missingness during June, July, and August, the warmest months of the warm season (April through September). Missing data considerations are important when defining periods of extreme heat. Spatio-temporal methods are recommended for data imputation. A heat wave definition that incorporates information from all monitors is advised.

  9. Guidelines for reporting evaluations based on observational methodology.

    PubMed

    Portell, Mariona; Anguera, M Teresa; Chacón-Moscoso, Salvador; Sanduvete-Chaves, Susana

    2015-01-01

    Observational methodology is one of the most suitable research designs for evaluating fidelity of implementation, especially in complex interventions. However, the conduct and reporting of observational studies is hampered by the absence of specific guidelines, such as those that exist for other evaluation designs. This lack of specific guidance poses a threat to the quality and transparency of these studies and also constitutes a considerable publication hurdle. The aim of this study thus was to draw up a set of proposed guidelines for reporting evaluations based on observational methodology. The guidelines were developed by triangulating three sources of information: observational studies performed in different fields by experts in observational methodology, reporting guidelines for general studies and studies with similar designs to observational studies, and proposals from experts in observational methodology at scientific meetings. We produced a list of guidelines grouped into three domains: intervention and expected outcomes, methods, and results. The result is a useful, carefully crafted set of simple guidelines for conducting and reporting observational studies in the field of program evaluation.

  10. Children's Avoidance of Interrupting Others' Activities in Requesting Help: Cultural Aspects of Considerateness.

    PubMed

    Ruvalcaba, Omar; Rogoff, Barbara; López, Angélica; Correa-Chávez, Maricela; Gutiérrez, Kris

    2015-01-01

    To be able to collaborate skillfully, people need to coordinate well with others, taking into account how their actions fit with those of their partners. This is a key aspect of an approach to learning called Learning by Observing and Pitching In, hypothesized to be common in many Indigenous-heritage communities of the Americas. This chapter considers cultural values that emphasize considerateness and awareness of how one's actions impact others such as the Mexican cultural value of respeto and cultural differences in children's efforts to avoid interrupting others' activity. US Mexican-heritage children showed more evidence of avoiding interrupting the ongoing activity of an adult when they requested help, compared with European American children from families with extensive schooling experience. Most of the Mexican-heritage children's requests for help that gave evidence of avoiding interruption were made nonverbally, which may facilitate unobtrusive requests. There were no significant differences among children from two US Mexican-heritage backgrounds varying in experience with Western schooling and likely experience with Indigenous-American practices, suggesting that the Mexican cultural value of respeto and associated considerateness is widespread even among US Mexican-heritage families with extensive experience with Western schooling and life in the United States. © 2015 Elsevier Inc. All rights reserved.

  11. Interpreting the Latitudinal Structure of Differences Between Modeled and Observed Temperature Trends (Invited)

    NASA Astrophysics Data System (ADS)

    Santer, B. D.; Mears, C. A.; Gleckler, P. J.; Solomon, S.; Wigley, T.; Arblaster, J.; Cai, W.; Gillett, N. P.; Ivanova, D. P.; Karl, T. R.; Lanzante, J.; Meehl, G. A.; Stott, P.; Taylor, K. E.; Thorne, P.; Wehner, M. F.; Zou, C.

    2010-12-01

    We perform the most comprehensive comparison to date of simulated and observed temperature trends. Comparisons are made for different latitude bands, timescales, and temperature variables, using information from a multi-model archive and a variety of observational datasets. Our focus is on temperature changes in the lower troposphere (TLT), the mid- to upper troposphere (TMT), and at the sea surface (SST). For SST, TLT, and TMT, trend comparisons over the satellite era (1979 to 2009) always yield closest agreement in mid-latitudes of the Northern Hemisphere. There are pronounced discrepancies in the tropics and in the Southern Hemisphere: in both regions, the multi-model average warming is consistently larger than observed. At high latitudes in the Northern Hemisphere, the observed tropospheric warming exceeds multi-model average trends. The similarity in the latitudinal structure of this discrepancy pattern across different temperature variables and observational data sets suggests that these trend differences are real, and are not due to residual inhomogeneities in the observations. The interpretation of these results is hampered by the fact that the CMIP-3 multi-model archive analyzed here convolves errors in key external forcings with errors in the model response to forcing. Under a "forcing error" interpretation, model-average temperature trends in the Southern Hemisphere extratropics are biased warm because many models neglect (and/or inaccurately specify) changes in stratospheric ozone and the indirect effects of aerosols. An alternative "response error" explanation for the model trend errors is that there are fundamental problems with model clouds and ocean heat uptake over the Southern Ocean. When SST changes are compared over the longer period 1950 to 2009, there is close agreement between simulated and observed trends poleward of 50°S. This result is difficult to reconcile with the hypothesis that the trend discrepancies over 1979 to 2009 are primarily

  12. Anxiety in Chinese EFL Students at Different Proficiency Levels

    ERIC Educational Resources Information Center

    Liu, Meihua

    2006-01-01

    This paper reports a study on anxiety in Chinese undergraduate non-English majors at three different proficiency levels. By way of survey, observations, reflective journals and interviews, the study revealed that (1) a considerable number of students at each level felt anxious when speaking English in class, (2) the more proficient students tended…

  13. Ring Current Response to Different Storm Drivers. Van Allen Probes and Cluster Observations.

    NASA Astrophysics Data System (ADS)

    Bingham, S.; Mouikis, C.; Kistler, L. M.; Spence, H. E.; Gkioulidou, M.; Claudepierre, S. G.; Farrugia, C. J.

    2015-12-01

    The ring current responds differently to the different solar and interplanetary storm drivers such as coronal mass injections, (CME's), co-rotating interaction regions (CIR's), high-speed streamers and other structures. The resulting changes in the ring current particle pressure change the global magnetic field, which affects the transport of the radiation belts. In order to determine the field changes during a storm it is necessary to understand the transport, sources and losses of the particles that contribute to the ring current. The source population of the storm time ring current is the night side plasma sheet. However, it is not clear how these convecting particles affect the storm time ring current pressure development. We use Van Allen Probes and Cluster observations together with the Volland-Stern and dipole magnetic field models to determine the contribution in the ring current pressure of the plasma sheet particles convecting from the night side that are on open drift paths, during the storm evolution. We compare storms that are related to different interplanetary drivers, CME and CIR, as observed at different local times.

  14. Investigations of suprathreshold color-difference tolerances with different visual scales and different perceptual correlates using CRT colors.

    PubMed

    Wang, Zhehong; Xu, Haisong

    2008-12-01

    In order to investigate the performance of suprathreshold color-difference tolerances with different visual scales and different perceptual correlates, a psychophysical experiment was carried out by the method of constant stimuli using CRT colors. Five hue circles at three lightness (L*=30, 50, and 70) and chroma (C*ab=10, 20, and 30) levels were selected to ensure that the color-difference tolerances did not exceed the color gamut of the CRT display. Twelve color centers distributed evenly every 30 degrees along each hue circle were assessed by a panel of eight observers, and the corresponding color-difference tolerances were obtained. The hue circle with L*=50 and C*ab=20 was assessed with three different visual scales (DeltaV=3.06, 5.92, and 8.87 CIELAB units), which ranged from small to large visual scales, while the remaining hue circles were observed only with the small visual scale. The lightness tolerances had no significant correlation with the hue angles, while chroma and hue tolerances showed considerable hue angle dependences. The color-difference tolerances were linearly proportional to the visual scales but with different slopes. The lightness tolerances with different lightness levels but the same chroma showed the crispening effect to some extent, while the chroma and hue tolerances decreased with the increment of the lightness. For the color-difference tolerances with different chroma levels but the same lightness, there was no correlation between the lightness tolerances and the chroma levels, while the chroma and hue tolerances were nearly linearly proportional to the chroma levels.

  15. Monitoring arid lands using AVHRR-observed visible reflectance and SMMR37-GHz polarization difference

    NASA Technical Reports Server (NTRS)

    Choudhury, B. J.

    1990-01-01

    Visible reflectance along a transect through the Sahel and Sudan zones of Africa has been derived from observations by the AVHRR on the NOAA-7 and NOAA-9 satellites and compared with concurrent observations of the 37-GHz polarization difference by the SMMR on the Nimbus-7 satellite. The study period was January 1982 to December 1986, which included an unprecedented drought during 1984 over the Sahel zone. While spatial and temporal patterns of these two data sets are found to be highly correlated, there are also quantitative differences which need to be understood.

  16. Measuring Individual Differences in Decision Biases: Methodological Considerations

    PubMed Central

    Aczel, Balazs; Bago, Bence; Szollosi, Aba; Foldes, Andrei; Lukacs, Bence

    2015-01-01

    Individual differences in people's susceptibility to heuristics and biases (HB) are often measured by multiple-bias questionnaires consisting of one or a few items for each bias. This research approach relies on the assumptions that (1) different versions of a decision bias task measure are interchangeable as they measure the same cognitive failure; and (2) that some combination of these tasks measures the same underlying construct. Based on these assumptions, in Study 1 we developed two versions of a new decision bias survey for which we modified 13 HB tasks to increase their comparability, construct validity, and the participants' motivation. The analysis of the responses (N = 1279) showed weak internal consistency within the surveys and a great level of discrepancy between the extracted patterns of the underlying factors. To explore these inconsistencies, in Study 2 we used three original examples of HB tasks for each of seven biases. We created three decision bias surveys by allocating one version of each HB task to each survey. The participants' responses (N = 527) showed a similar pattern as in Study 1, questioning the assumption that the different examples of the HB tasks are interchangeable and that they measure the same underlying construct. These results emphasize the need to understand the domain-specificity of cognitive biases as well as the effect of the wording of the cover story and the response mode on bias susceptibility before employing them in multiple-bias questionnaires. PMID:26635677

  17. Observability of Boolean multiplex control networks

    NASA Astrophysics Data System (ADS)

    Wu, Yuhu; Xu, Jingxue; Sun, Xi-Ming; Wang, Wei

    2017-04-01

    Boolean multiplex (multilevel) networks (BMNs) are currently receiving considerable attention as theoretical arguments for modeling of biological systems and system level analysis. Studying control-related problems in BMNs may not only provide new views into the intrinsic control in complex biological systems, but also enable us to develop a method for manipulating biological systems using exogenous inputs. In this article, the observability of the Boolean multiplex control networks (BMCNs) are studied. First, the dynamical model and structure of BMCNs with control inputs and outputs are constructed. By using of Semi-Tensor Product (STP) approach, the logical dynamics of BMCNs is converted into an equivalent algebraic representation. Then, the observability of the BMCNs with two different kinds of control inputs is investigated by giving necessary and sufficient conditions. Finally, examples are given to illustrate the efficiency of the obtained theoretical results.

  18. Behavioral and brain pattern differences between acting and observing in an auditory task

    PubMed Central

    Karanasiou, Irene S; Papageorgiou, Charalabos; Tsianaka, Eleni I; Matsopoulos, George K; Ventouras, Errikos M; Uzunoglu, Nikolaos K

    2009-01-01

    Background Recent research has shown that errors seem to influence the patterns of brain activity. Additionally current notions support the idea that similar brain mechanisms are activated during acting and observing. The aim of the present study was to examine the patterns of brain activity of actors and observers elicited upon receiving feedback information of the actor's response. Methods The task used in the present research was an auditory identification task that included both acting and observing settings, ensuring concurrent ERP measurements of both participants. The performance of the participants was investigated in conditions of varying complexity. ERP data were analyzed with regards to the conditions of acting and observing in conjunction to correct and erroneous responses. Results The obtained results showed that the complexity induced by cue dissimilarity between trials was a demodulating factor leading to poorer performance. The electrophysiological results suggest that feedback information results in different intensities of the ERP patterns of observers and actors depending on whether the actor had made an error or not. The LORETA source localization method yielded significantly larger electrical activity in the supplementary motor area (Brodmann area 6), the posterior cingulate gyrus (Brodmann area 31/23) and the parietal lobe (Precuneus/Brodmann area 7/5). Conclusion These findings suggest that feedback information has a different effect on the intensities of the ERP patterns of actors and observers depending on whether the actor committed an error. Certain neural systems, including medial frontal area, posterior cingulate gyrus and precuneus may mediate these modulating effects. Further research is needed to elucidate in more detail the neuroanatomical and neuropsychological substrates of these systems. PMID:19154586

  19. The magnetic field of the earth - Performance considerations for space-based observing systems

    NASA Technical Reports Server (NTRS)

    Webster, W. J., Jr.; Taylor, P. T.; Schnetzler, C. C.; Langel, R. A.

    1985-01-01

    Basic problems inherent in carrying out observations of the earth magnetic field from space are reviewed. It is shown that while useful observations of the core and crustal fields are possible at the peak of the solar cycle, the greatest useful data volume is obtained during solar minimum. During the last three solar cycles, the proportion of data with a planetary disturbance index of less than 2 at solar maximum was in the range 0.4-0.8 in comparison with solar minimum. It is found that current state of the art orbit determination techniques should eliminate orbit error as a problem in gravitational field measurements from space. The spatial resolution obtained for crustal field anomalies during the major satellite observation programs of the last 30 years are compared in a table. The relationship between observing altitude and the spatial resolution of magnetic field structures is discussed. Reference is made to data obtained using the Magsat, the Polar Orbiting Geophysical Observatory (POGO), and instruments on board the Space Shuttle.

  20. Similarities and differences in mothers' and observers' ratings of infant security on the Attachment Q-Sort.

    PubMed

    Tarabulsy, George M; Provost, Marc A; Larose, Simon; Moss, Ellen; Lemelin, Jean-Pascal; Moran, Greg; Forbes, Lindsey; Pederson, David R

    2008-01-01

    This study examined the similarities and differences in maternal and observer Attachment Behavior Q-Sort ratings (AQS; Waters, 1995) and their relations to dimensions of the developmental ecology - maternal sensitivity, infant irritability, parental stress and psychosocial risk. Data was gathered from low risk (adult mothers; N=44) and high risk mother-infant dyads (adolescent mothers; N=83) when infants were aged 6, 10 and 15 months old, attachment being assessed at 15 months by both mothers and independent observers. A common factor was extracted from both sorts and served to operationalize the similarities between mother and observer ratings. Regressions were conducted to extract maternal and observer AQS scores that were unrelated to each other to represent the difference between the two sorts. Correlation analyses indicated that the common AQS factor was moderately linked to maternal sensitivity and parental stress, and showed a weak association to psychosocial risk and infant irritability. Residual maternal scores showed greater correlations with infant irritability and parental stress than did observer residual scores. Observer scores showed a greater correlation with psychosocial risk than maternal scores. Results suggest that common AQS variance presents a pattern of associations with ecological variables that is coherent with attachment research. Variance related to irritability, stress and risk appear to drive the differences between maternal and observer observations.

  1. Design considerations for Mars photovoltaic power systems

    NASA Technical Reports Server (NTRS)

    Landis, Geoffrey A.; Appelbaum, Joseph

    1990-01-01

    Considerations for operation of a photovoltaic power system on Mars are discussed with reference to Viking Lander data. The average solar insolation at Mars is 590 W/sq m, which is reduced yet further by atmospheric dust. Of major concern are dust storms, which have been observed to occur on local as well as on global scales, and their effect on solar array output. While atmospheric opacity may rise to values ranging from 3 to 9, depending on storm severity, there is still an appreciable large diffuse illumination, even at high opacities, so that photovoltaic operation is still possible. If the power system is to continue to generate power even on high-optical-opacity (i.e., dusty atmosphere) days, it is important that the photovoltaic system be designed to collect diffuse irradiance as well as direct. Energy storage will be required for operation during the night. Temperature and wind provide additional considerations for array design.

  2. Statistical considerations in creating water vapor data records from combinations of satellite and other observation types, including in situ and ground-based remote sensing

    NASA Astrophysics Data System (ADS)

    Dykema, J. A.; Anderson, J. G.

    2014-12-01

    Measuring water vapor at the highest spatial and temporal at all vertical levels and at arbitrary times requires strategic utilization of disparate observations from satellites, ground-based remote sensing, and in situ measurements. These different measurement types have different response times and very different spatial averaging properties, both horizontally and vertically. Accounting for these different measurement properties and explicit propagation of associated uncertainties is necessary to test particular scientific hypotheses, especially in cases of detection of weak signals in the presence of natural fluctuations, and for process studies with small ensembles. This is also true where ancillary data from meteorological analyses are required, which have their own sampling limitations and uncertainties. This study will review two investigations pertaining to measurements of water vapor in the mid-troposphere and lower stratosphere that mix satellite observations with observations from other sources. The focus of the mid-troposphere analysis is to obtain improved estimates of water vapor at the instant of a sounding satellite overpass. The lower stratosphere work examines the uncertainty inherent in a small ensemble of anomalously elevated lower stratospheric water vapor observations when meteorological analysis products and aircraft in situ observations are required for interpretation.

  3. Methodological and Epistemological Considerations in Utilizing Qualitative Inquiry to Develop Interventions.

    PubMed

    Duggleby, Wendy; Williams, Allison

    2016-01-01

    The purpose of this article is to discuss methodological and epistemological considerations involved in using qualitative inquiry to develop interventions. These considerations included (a) using diverse methodological approaches and (b) epistemological considerations such as generalization, de-contextualization, and subjective reality. Diverse methodological approaches have the potential to inform different stages of intervention development. Using the development of a psychosocial hope intervention for advanced cancer patients as an example, the authors utilized a thematic study to assess current theories/frameworks and interventions. However, to understand the processes that the intervention needed to target to affect change, grounded theory was used. Epistemological considerations provided a framework to understand and, further, critique the intervention. Using diverse qualitative methodological approaches and examining epistemological considerations were useful in developing an intervention that appears to foster hope in patients with advanced cancer. © The Author(s) 2015.

  4. Japanese Sex Differences in Preferred & Observed Divisions of Labor in the Home.

    ERIC Educational Resources Information Center

    Engel, John W.

    This research describes sex roles and divisions of labor observed in families of origin by contemporary Japanese (n=1,000) and contemporary preferences for division or sharing of family tasks. It then compares these preferences to determine whether significant differences exist between men and women in contemporary Japan. For their present and…

  5. Comparing different Ultraviolet Imaging Spectrograph (UVIS) occultation observations using modeling of water vapor jets

    NASA Astrophysics Data System (ADS)

    Portyankina, Ganna; Esposito, Larry W.; Hansen, Candice; Aye, Klaus-Michael

    2016-10-01

    Motivation: On March 11, 2016 the Cassini UVIS observed its 6th star occultation by Enceladus' plume. This observation was aimed to determine variability in the total gas flux from the Enceladus' southern polar region. The analysis of the received data suggests that the total gas flux is moderately increased comparing to the average gas flux observed by UVIS from 2005 to 2011 [1]. However, UVIS detected variability in individual jets. In particular, Baghdad 1 is more collimated in 2016 than in 2005, meaning its gas escapes at higher velocity.Model and fits: We use 3D DSMC model for water vapor jets to compare different UVIS occultation observations from 2005 to 2016. The model traces test articles from jets' sources [2] into space and results in coordinates and velocities for a set of test particles. We convert particle positions into the particle number density and integrate along UVIS line of sight (LoS) for each time step of the UVIS observation using precise observational geometry derived from SPICE [3]. We integrate all jets that are crossed by the LoS and perform constrained least-squares fit of resulting modeled opacities to the observed data to solved for relative strengths of jets. The geometry of each occultation is specific, for example, during solar occultation in 2010 UVIS LoS was almost parallel to tiger stripes, which made it possible to distinguish jets venting from different tiger stripes. In 2011 Eps Orionis occultation LoS was perpendicular to tiger stripes and thus many of the jets were geometrically overlapping. Solar occultation provided us with the largest inventory of active jets - our model fit detects at least 43 non-zero jet contributions. Stellar occultations generally have lower temporal resolution and observe only a sub-set of these jets: 2011 Eps Orionis needs minimum 25 non-zero jets to fit UVIS data. We will discuss different occultations and models fits, including the most recent Epsilon Orionis occultation of 2016.[1] Hansen et al

  6. Observability analysis of DVL/PS aided INS for a maneuvering AUV.

    PubMed

    Klein, Itzik; Diamant, Roee

    2015-10-22

    Recently, ocean exploration has increased considerably through the use of autonomous underwater vehicles (AUV). A key enabling technology is the precision of the AUV navigation capability. In this paper, we focus on understanding the limitation of the AUV navigation system. That is, what are the observable error-states for different maneuvering types of the AUV? Since analyzing the performance of an underwater navigation system is highly complex, to answer the above question, current approaches use simulations. This, of course, limits the conclusions to the emulated type of vehicle used and to the simulation setup. For this reason, we take a different approach and analyze the system observability for different types of vehicle dynamics by finding the set of observable and unobservable states. To that end, we apply the observability Gramian approach, previously used only for terrestrial applications. We demonstrate our analysis for an underwater inertial navigation system aided by a Doppler velocity logger or by a pressure sensor. The result is a first prediction of the performance of an AUV standing, rotating at a position and turning at a constant speed. Our conclusions of the observable and unobservable navigation error states for different dynamics are supported by extensive numerical simulation.

  7. Observability Analysis of DVL/PS Aided INS for a Maneuvering AUV

    PubMed Central

    Klein, Itzik; Diamant, Roee

    2015-01-01

    Recently, ocean exploration has increased considerably through the use of autonomous underwater vehicles (AUV). A key enabling technology is the precision of the AUV navigation capability. In this paper, we focus on understanding the limitation of the AUV navigation system. That is, what are the observable error-states for different maneuvering types of the AUV? Since analyzing the performance of an underwater navigation system is highly complex, to answer the above question, current approaches use simulations. This, of course, limits the conclusions to the emulated type of vehicle used and to the simulation setup. For this reason, we take a different approach and analyze the system observability for different types of vehicle dynamics by finding the set of observable and unobservable states. To that end, we apply the observability Gramian approach, previously used only for terrestrial applications. We demonstrate our analysis for an underwater inertial navigation system aided by a Doppler velocity logger or by a pressure sensor. The result is a first prediction of the performance of an AUV standing, rotating at a position and turning at a constant speed. Our conclusions of the observable and unobservable navigation error states for different dynamics are supported by extensive numerical simulation. PMID:26506356

  8. Considerations for throughfall chemistry sample-size determination

    Treesearch

    Pamela J. Edwards; Paul Mohai; Howard G. Halverson; David R. DeWalle

    1989-01-01

    Both the number of trees sampled per species and the number of sampling points under each tree are important throughfall sampling considerations. Chemical loadings obtained from an urban throughfall study were used to evaluate the relative importance of both of these sampling factors in tests for determining species' differences. Power curves for detecting...

  9. A Dynamic Approach to Addressing Observation-Minus-Forecast Mean Differences in a Land Surface Skin Temperature Data Assimilation System

    NASA Technical Reports Server (NTRS)

    Draper, Clara; Reichle, Rolf; De Lannoy, Gabrielle; Scarino, Benjamin

    2015-01-01

    In land data assimilation, bias in the observation-minus-forecast (O-F) residuals is typically removed from the observations prior to assimilation by rescaling the observations to have the same long-term mean (and higher-order moments) as the corresponding model forecasts. Such observation rescaling approaches require a long record of observed and forecast estimates, and an assumption that the O-F mean differences are stationary. A two-stage observation bias and state estimation filter is presented, as an alternative to observation rescaling that does not require a long data record or assume stationary O-F mean differences. The two-stage filter removes dynamic (nonstationary) estimates of the seasonal scale O-F mean difference from the assimilated observations, allowing the assimilation to correct the model for synoptic-scale errors without adverse effects from observation biases. The two-stage filter is demonstrated by assimilating geostationary skin temperature (Tsk) observations into the Catchment land surface model. Global maps of the O-F mean differences are presented, and the two-stage filter is evaluated for one year over the Americas. The two-stage filter effectively removed the Tsk O-F mean differences, for example the GOES-West O-F mean difference at 21:00 UTC was reduced from 5.1 K for a bias-blind assimilation to 0.3 K. Compared to independent in situ and remotely sensed Tsk observations, the two-stage assimilation reduced the unbiased Root Mean Square Difference (ubRMSD) of the modeled Tsk by 10 of the open-loop values.

  10. Identifying Heat Waves in Florida: Considerations of Missing Weather Data

    PubMed Central

    Leary, Emily; Young, Linda J.; DuClos, Chris; Jordan, Melissa M.

    2015-01-01

    Background Using current climate models, regional-scale changes for Florida over the next 100 years are predicted to include warming over terrestrial areas and very likely increases in the number of high temperature extremes. No uniform definition of a heat wave exists. Most past research on heat waves has focused on evaluating the aftermath of known heat waves, with minimal consideration of missing exposure information. Objectives To identify and discuss methods of handling and imputing missing weather data and how those methods can affect identified periods of extreme heat in Florida. Methods In addition to ignoring missing data, temporal, spatial, and spatio-temporal models are described and utilized to impute missing historical weather data from 1973 to 2012 from 43 Florida weather monitors. Calculated thresholds are used to define periods of extreme heat across Florida. Results Modeling of missing data and imputing missing values can affect the identified periods of extreme heat, through the missing data itself or through the computed thresholds. The differences observed are related to the amount of missingness during June, July, and August, the warmest months of the warm season (April through September). Conclusions Missing data considerations are important when defining periods of extreme heat. Spatio-temporal methods are recommended for data imputation. A heat wave definition that incorporates information from all monitors is advised. PMID:26619198

  11. Different decay patterns observed in a nineteenth-century building (Palma, Spain).

    PubMed

    Genestar, Catalina; Pons, Carmen; Cerro, José Carlos; Cerdà, Víctor

    2014-01-01

    The effects of atmospheric pollutants and climatic conditions were studied in a decayed column in the Seminary of Sant Pere. This nineteenth-century building is situated in the historic centre of Palma (Mallorca, Spain), less than 0.5 km from the sea. Samples were collected from the internal and external part of the crusts formed in the four sides of the column. The samples were analysed by means of thermal analysis, X-ray diffractometry, scanning electron microscopy, Fourier transform infrared spectroscopy and ion chromatography. Results show significant differences in the four sides of the column. A high degree of carbonate stone sulfation is observed in all of the samples analysed. A synergistic effect between atmospheric factors and micropollutants on the deterioration of stone is observed. A high uptake of atmospheric particulate matter is found in the external part of the black crusts.

  12. Comparison of PARASOL Observations with Polarized Reflectances Simulated Using Different Ice Habit Mixtures

    NASA Technical Reports Server (NTRS)

    Cole, Benjamin H.; Yang, Ping; Baum, Bryan A.; Riedi, Jerome; Labonnote, Laurent C.; Thieuleux, Francois; Platnick, Steven

    2012-01-01

    Insufficient knowledge of the habit distribution and the degree of surface roughness of ice crystals within ice clouds is a source of uncertainty in the forward light scattering and radiative transfer simulations required in downstream applications involving these clouds. The widely used MODerate Resolution Imaging Spectroradiometer (MODIS) Collection 5 ice microphysical model assumes a mixture of various ice crystal shapes with smooth-facets except aggregates of columns for which a moderately rough condition is assumed. When compared with PARASOL (Polarization and Anisotropy of Reflectances for Atmospheric Sciences coupled with Observations from a Lidar) polarized reflection data, simulations of polarized reflectance using smooth particles show a poor fit to the measurements, whereas very rough-faceted particles provide an improved fit to the polarized reflectance. In this study a new microphysical model based on a mixture of 9 different ice crystal habits with severely roughened facets is developed. Simulated polarized reflectance using the new ice habit distribution is calculated using a vector adding-doubling radiative transfer model, and the simulations closely agree with the polarized reflectance observed by PARASOL. The new general habit mixture is also tested using a spherical albedo differences analysis, and surface roughening is found to improve the consistency of multi-angular observations. It is suggested that an ice model incorporating an ensemble of different habits with severely roughened surfaces would potentially be an adequate choice for global ice cloud retrievals.

  13. Energy considerations in real estate appraising

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1980-04-01

    Purposes of the seminar on the subject, the basis of this report, include the following: (1) to provide the appraiser an opportunity to learn how to identify and analyze the actual physical consumption of energy as well as the energy-saving improvements in properties under appraisal and in comparable sale and lease properties; (2) to help the appraiser in developing methods to keep meaningful records on the energy consumption of subject and comparable properties so as to observe in an orderly way the behavior of buyers, sellers, tenants, landlords, borrowers, and lenders with respect to energy efficiency; and (3) to assistmore » the appraiser in learning to measure the relative sensitivities of the various segments of the market to energy considerations as indicated by differences in sale prices and rentals. To achieve these goals, the seminar employed two case studies, one for a angle-family residence and one for a multi-family building, both in Topeka, Kansas. The case studies are for illustrative purposes only; in applying the lessons of the seminar to their own daily work, students should be careful to develop information that is pertinent to their subject properties and subject areas and not rely on any of the particulars laid out in the cases.« less

  14. Methodological considerations for studying social processes.

    PubMed

    Patterson, Barbara; Morin, Karen

    2012-01-01

    To discuss the nature of and considerations in the study of social processes. Social processes include the elements of time, change and human interaction and many phenomena of interest to nurse researchers. Despite the significance of social processes for nursing practice and the labelling in many studies of phenomena as processes, there seems to be an inability to describe processes fully. The paper includes a presentation of two methodological approaches for illuminating the dynamics of social processes: participant observation and prospective time-series designs. Strengths and limitations of the two paradigmatically different approaches are offered. The method an investigator chooses should be considered selectively and appropriately according to the nature of the problem, what is known about the phenomena to be studied, and the investigator's world view and theoretical perspective. The conceptualisation of process can also influence the methodological choice. Capturing a social process in its entirety with either a qualitative or quantitative approach can be a difficult task. The focus of this paper is an initiation and expansion of the dialogue about which methods provide the best insight into social processes. This knowledge may offer opportunities for nurse researchers to design and implement interventions for individuals as they progress through life events.

  15. The Ripple Tank: Management and Observation

    ERIC Educational Resources Information Center

    Auty, Geoff

    2017-01-01

    This overview is intended to help colleagues achieve successful and satisfying observations using a ripple tank. There are many observations to consider that can effectively illustrate reflection, refraction, interference and diffraction, but the most important consideration is to make every effort to enable students to see the effects we want…

  16. Biologic relativity: Who is the observer and what is observed?

    PubMed

    Torday, John S; Miller, William B

    2016-05-01

    When quantum physics and biological phenomena are analogously explored, it emerges that biologic causation must also be understood independently of its overt appearance. This is similar to the manner in which Bohm characterized the explicate versus the implicate order as overlapping frames of ambiguity. Placed in this context, the variables affecting epigenetic inheritance can be properly assessed as a key mechanistic principle of evolution that significantly alters our understanding of homeostasis, pleiotropy, and heterochrony, and the purposes of sexual reproduction. Each of these become differing manifestations of a new biological relativity in which biologic space-time becomes its own frame. In such relativistic cellular contexts, it is proper to question exactly who has observer status, and who and what are being observed. Consideration within this frame reduces biology to cellular information sharing through cell-cell communication to resolve ambiguities at every scope and scale. In consequence, it becomes implicit that eukaryotic evolution derives from the unicellular state, remaining consistently adherent to it in a continuous evolutionary arc based upon elemental, non-stochastic physiologic first principles. Furthermore, the entire cell including its cytoskeletal apparatus and membranes that participate in the resolution of biological uncertainties must be considered as having equivalent primacy with genomes in evolutionary terms. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. Some considerations about the use of different sensors, in coordinate measuring of the small parts

    NASA Astrophysics Data System (ADS)

    Drăgan, L.

    2017-05-01

    The paper presents some particular aspects associated with measuring of the small-size parts with high precision, manufactured by injection procedures. The coordinate measuring machine (CMM) are very used in process of measuring parts with different shapes, dimensions and materials of the most varied. It is studied by experiments, the influence of hygroscopicity on the geometrical properties of polyamide parts, using different types of measuring sensors. We selected a few pieces- cover type, with precision features dimensions and shape tolerances. To measure them was used some sensors which is equipped CMM ScopeCheck S 400 and equipment for dehumidifying. Starting from the need for high precision measurement of geometric characteristics of the parts obtained by injection of plastic, it has been found that the hygroscopicity has a significant influence. To achieve the purpose were used three types of measuring sensors under different conditions of keeping after manufacture. It was observed that the influence of humidity is significantly reduced if the parts are kept in exikator or vacuum dryer.

  18. COMPARATIVE STUDY OF ASYMMETRY ORIGIN OF GALAXIES IN DIFFERENT ENVIRONMENTS. I. OPTICAL OBSERVATIONS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Plauchu-Frayn, I.; Coziol, R., E-mail: plauchuf@astro.ugto.m, E-mail: rcoziol@astro.ugto.m

    2010-06-15

    This paper presents the first of two analyses about the influence of environment on the formation and evolution of galaxies observed in the nearby universe. For our study, we used three different samples representing different density environments: galaxies in Compact Groups (HCGs), Isolated Pairs of Galaxies (KPGs), and Isolated Galaxies (KIGs), which were taken as references. Usingboth characteristic isophotal parameters and evidence of asymmetries in the optical and the near-infrared, we are able to establish differences in the characteristics of galaxies with different morphologies in different environments, allowing us to better understand their different formation histories. In this first paper,more » we present the isophotal and asymmetry analyses of a sample of 214 galaxies in different environments observed in the optical (V and I images). For each galaxy, we have determined different characteristic isophotal parameters and V - I color profiles, as a function of semi-major axis, and performed a full asymmetry analysis in residual images using the V filter. Evidence of asymmetry in the optical is almost missing in the KIG sample and significantly more common in the KPG than in the HCG samples. Our isophotal analysis suggests that the stellar populations in the HCG galaxies are older and more dynamically relaxed than in the KPG. The HCG galaxies seem to be at a more advanced stage of interaction than the KPGs. One possible explanation is that these structures formed at different epochs: compact groups of galaxies would have formed before close pairs of galaxies, which only began interacting recently. However, similarities in the formation process of galaxies with same morphology suggest CGs and close pairs of galaxies share similar conditions; they are new structures forming relatively late in low-density environments.« less

  19. Comparative assessment of nanomaterial definitions and safety evaluation considerations.

    PubMed

    Boverhof, Darrell R; Bramante, Christina M; Butala, John H; Clancy, Shaun F; Lafranconi, Mark; West, Jay; Gordon, Steve C

    2015-10-01

    Nanomaterials continue to bring promising advances to science and technology. In concert have come calls for increased regulatory oversight to ensure their appropriate identification and evaluation, which has led to extensive discussions about nanomaterial definitions. Numerous nanomaterial definitions have been proposed by government, industry, and standards organizations. We conducted a comprehensive comparative assessment of existing nanomaterial definitions put forward by governments to highlight their similarities and differences. We found that the size limits used in different definitions were inconsistent, as were considerations of other elements, including agglomerates and aggregates, distributional thresholds, novel properties, and solubility. Other important differences included consideration of number size distributions versus weight distributions and natural versus intentionally-manufactured materials. Overall, the definitions we compared were not in alignment, which may lead to inconsistent identification and evaluation of nanomaterials and could have adverse impacts on commerce and public perceptions of nanotechnology. We recommend a set of considerations that future discussions of nanomaterial definitions should consider for describing materials and assessing their potential for health and environmental impacts using risk-based approaches within existing assessment frameworks. Our intent is to initiate a dialogue aimed at achieving greater clarity in identifying those nanomaterials that may require additional evaluation, not to propose a formal definition. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  20. Coronal Heating and the Need for High-Resolution Observations

    NASA Technical Reports Server (NTRS)

    Klimchuk, James A.

    2008-01-01

    Despite excellent progress in recent years in understanding coronal heating, there remain many crucial questions that are still unanswered. Limitations in the observations are one important reason. Both theoretical and observational considerations point to the importance of small spatial scales, impulsive energy release, strong dynamics, and extreme plasma nonuniformity. As a consequence, high spatial resolution, broad temperature coverage, high temperature fidelity, and sensitivity to velocities and densities are all critical observational parameters. Current instruments lack one or more of these properties, and this has led to considerable ambiguity and confusion. In this talk, I will discuss recent ideas about coronal heating and emphasize that high spatial resolution observations, especially spectroscopic observations, are needed to make major progress on this important problem.

  1. Calibration of hyperspectral data aviation mode according with accompanying ground-based measurements of standard surfaces of observed scenes

    NASA Astrophysics Data System (ADS)

    Ostrikov, V. N.; Plakhotnikov, O. V.

    2014-12-01

    Using considerable experimental material, we examine whether it is possible to recalculate the initial data of hyperspectral aircraft survey into spectral radiance factors (SRF). The errors of external calibration for various observation conditions and different instruments for data receiving are estimated.

  2. Experimental observation of different soliton types in a net-normal group-dispersion fiber laser.

    PubMed

    Feng, Zhongyao; Rong, Qiangzhou; Qiao, Xueguang; Shao, Zhihua; Su, Dan

    2014-09-20

    Different soliton types are observed in a net-normal group-dispersion fiber laser based on nonlinear polarization rotation for passive mode locking. The proposed laser can deliver a dispersion-managed soliton, typical dissipation solitons, and a quasi-harmonic mode-locked pulse, a soliton bundle, and especially a dark pulse by only appropriately adjusting the linear cavity phase delay bias using one polarization controller at the fixed pump power. These nonlinear waves show different features, including the spectral shapes and time traces. The experimental observations show that the five soliton types could exist in the same laser cavity, which implies that integrable systems, dissipative systems, and dark pulse regimes can transfer and be switched in a passively mode-locked laser. Our studies not only verify the numeral simulation of the different soliton-types formation in a net-normal group-dispersion operation but also provide insight into Ginzburg-Landau equation systems.

  3. Physical properties of dust particles in different comets inferred from observations and experimental simulations

    NASA Astrophysics Data System (ADS)

    Hadamcik, E.; Levasseur-Regourd, A. C.

    2007-08-01

    1.Introduction Remote observations of solar light scattered by cometary dust particles provide information on the dust properties for a large variety of comets, in complement to the exceptional in-situ observations (with or without sample returns). The scattered light is partially linearly polarized, with a polarization degree depending on the geometry of observations (phase angle ?) and on the physical properties of the particles. Differences in polarization have been found in cometary comae, pointing to different physical properties of the dust (e.g. sizes of the grains, of the aggregates, structures and porosities, complex refractive indices) [1, 2]. Such differences, as well as an observed polarimetric wavelength effect, tend to show that large aggregates made of submicron-sized grains could be present in some cometary comae regions [3, 4]. On the opposite, more compact particles seem to be present in other comae regions and/or comets [5, 6]. 2. Results We will present observations of different comets. The variations of the dust properties in the coma and their evolution will be discussed. The results will be compared to the results obtained by other observational techniques. On the images of comet 9P/Tempel 1 (at ?=41°) some hours after Deep Impact, two kinds of dust particles are detected: more compact particles with small velocities and fluffy particles ejected by the impact with larger velocities. On the images of comet 73P/Schwassmann-Wachmann 3, in the tail direction of fragment B, a disruption is observed. The dust coma around fragment C is more symmetric. For both A and B, important dust jets are ejected by the nucleus, which are visible on the intensity images in the solar and antisolar directions, and on the polarization maps. 3. Interpretation and conclusion Numerical (7,8,9) and experimental simulations provide an interpretation of the observations in terms of the physical properties of the particles. Experimental simulations have been performed on

  4. Estimation and correction of different flavors of surface observation biases in ensemble Kalman filter

    NASA Astrophysics Data System (ADS)

    Lorente-Plazas, Raquel; Hacker, Josua P.; Collins, Nancy; Lee, Jared A.

    2017-04-01

    The impact of assimilating surface observations has been shown in several publications, for improving weather prediction inside of the boundary layer as well as the flow aloft. However, the assimilation of surface observations is often far from optimal due to the presence of both model and observation biases. The sources of these biases can be diverse: an instrumental offset, errors associated to the comparison of point-based observations and grid-cell average, etc. To overcome this challenge, a method was developed using the ensemble Kalman filter. The approach consists on representing each observation bias as a parameter. These bias parameters are added to the forward operator and they extend the state vector. As opposed to the observation bias estimation approaches most common in operational systems (e.g. for satellite radiances), the state vector and parameters are simultaneously updated by applying the Kalman filter equations to the augmented state. The method to estimate and correct the observation bias is evaluated using observing system simulation experiments (OSSEs) with the Weather Research and Forecasting (WRF) model. OSSEs are constructed for the conventional observation network including radiosondes, aircraft observations, atmospheric motion vectors, and surface observations. Three different kinds of biases are added to 2-meter temperature for synthetic METARs. From the simplest to more sophisticated, imposed biases are: (1) a spatially invariant bias, (2) a spatially varying bias proportional to topographic height differences between the model and the observations, and (3) bias that is proportional to the temperature. The target region characterized by complex terrain is the western U.S. on a domain with 30-km grid spacing. Observations are assimilated every 3 hours using an 80-member ensemble during September 2012. Results demonstrate that the approach is able to estimate and correct the bias when it is spatially invariant (experiment 1). More

  5. Dry Preservation of Spermatozoa: Considerations for Different Species.

    PubMed

    Patrick, Jennifer; Comizzoli, Pierre; Elliott, Gloria

    2017-04-01

    The current gold standard for sperm preservation is storage at cryogenic temperatures. Dry preservation is an attractive alternative, eliminating the need for ultralow temperatures, reducing storage maintenance costs, and providing logistical flexibility for shipping. Many seeds and anhydrobiotic organisms are able to survive extended periods in a dry state through the accumulation of intracellular sugars and other osmolytes and are capable of returning to normal physiology postrehydration. Using techniques inspired by nature's adaptations, attempts have been made to dehydrate and dry preserve spermatozoa from a variety of species. Most of the anhydrous preservation research performed to date has focused on mouse spermatozoa, with only a small number of studies in nonrodent mammalian species. There is a significant difference between sperm function in rodent and nonrodent mammalian species with respect to centrosomal inheritance. Studies focused on reproductive technologies have demonstrated that in nonrodent species, the centrosome must be preserved to maintain sperm function as the spermatozoon centrosome contributes the dominant nucleating seed, consisting of the proximal centriole surrounded by pericentriolar components, onto which the oocyte's centrosomal material is assembled. Preservation techniques used for mouse sperm may therefore not necessarily be applicable to nonrodent spermatozoa. The range of technologies used to dehydrate sperm and the effect of processing and storage conditions on fertilization and embryogenesis using dried sperm are reviewed in the context of reproductive physiology and cellular morphology in different species.

  6. Performance of thermally-chargeable supercapacitors in different solvents.

    PubMed

    Lim, Hyuck; Zhao, Cang; Qiao, Yu

    2014-07-07

    The influence of solvent on the temperature sensitivity of the electrode potential of thermally-chargeable supercapacitors (TCSs) is investigated. For large electrodes, the output voltage is positively correlated with the dielectric constant of solvent. When nanoporous carbon electrodes are used, different characteristics of system performance are observed, suggesting that possible size effects must be taken into consideration when the solvent molecules and solvated ions are confined in a nanoenvironment.

  7. Visual observations over oceans

    NASA Technical Reports Server (NTRS)

    Terry, R. D.

    1979-01-01

    Important factors in locating, identifying, describing, and photographing ocean features from space are presented. On the basis of crew comments and other findings, the following recommendations can be made for Earth observations on Space Shuttle missions: (1) flyover exercises must include observations and photography of both temperate and tropical/subtropical waters; (2) sunglint must be included during some observations of ocean features; (3) imaging remote sensors should be used together with conventional photographic systems to document visual observations; (4) greater consideration must be given to scheduling earth observation targets likely to be obscured by clouds; and (5) an annotated photographic compilation of ocean features can be used as a training aid before the mission and as a reference book during space flight.

  8. Our evolving understanding of aeolian bedforms, based on observation of dunes on different worlds

    NASA Astrophysics Data System (ADS)

    Diniega, Serina; Kreslavsky, Mikhail; Radebaugh, Jani; Silvestro, Simone; Telfer, Matt; Tirsch, Daniela

    2017-06-01

    Dunes, dune fields, and ripples are unique and useful records of the interaction between wind and granular materials - finding such features on a planetary surface immediately suggests certain information about climate and surface conditions (at least during the dunes' formation and evolution). Additionally, studies of dune characteristics under non-Earth conditions allow for ;tests; of aeolian process models based primarily on observations of terrestrial features and dynamics, and refinement of the models to include consideration of a wider range of environmental and planetary conditions. To-date, the planetary aeolian community has found and studied dune fields on Mars, Venus, and the Saturnian moon Titan. Additionally, we have observed candidate ;aeolian bedforms; on Comet 67P/Churyumov-Gerasimenko, the Jovian moon Io, and - most recently - Pluto. In this paper, we hypothesize that the progression of investigations of aeolian bedforms and processes on a particular planetary body follows a consistent sequence - primarily set by the acquisition of data of particular types and resolutions, and by the maturation of knowledge about that planetary body. We define that sequence of generated knowledge and new questions (within seven investigation phases) and discuss examples from all of the studied bodies. The aim of such a sequence is to better define our past and current state of understanding about the aeolian bedforms of a particular body, to highlight the related assumptions that require re-analysis with data acquired during later investigations, and to use lessons learned from planetary and terrestrial aeolian studies to predict what types of investigations could be most fruitful in the future.

  9. Dry Preservation of Spermatozoa: Considerations for Different Species

    PubMed Central

    Patrick, Jennifer; Comizzoli, Pierre

    2017-01-01

    The current gold standard for sperm preservation is storage at cryogenic temperatures. Dry preservation is an attractive alternative, eliminating the need for ultralow temperatures, reducing storage maintenance costs, and providing logistical flexibility for shipping. Many seeds and anhydrobiotic organisms are able to survive extended periods in a dry state through the accumulation of intracellular sugars and other osmolytes and are capable of returning to normal physiology postrehydration. Using techniques inspired by nature's adaptations, attempts have been made to dehydrate and dry preserve spermatozoa from a variety of species. Most of the anhydrous preservation research performed to date has focused on mouse spermatozoa, with only a small number of studies in nonrodent mammalian species. There is a significant difference between sperm function in rodent and nonrodent mammalian species with respect to centrosomal inheritance. Studies focused on reproductive technologies have demonstrated that in nonrodent species, the centrosome must be preserved to maintain sperm function as the spermatozoon centrosome contributes the dominant nucleating seed, consisting of the proximal centriole surrounded by pericentriolar components, onto which the oocyte's centrosomal material is assembled. Preservation techniques used for mouse sperm may therefore not necessarily be applicable to nonrodent spermatozoa. The range of technologies used to dehydrate sperm and the effect of processing and storage conditions on fertilization and embryogenesis using dried sperm are reviewed in the context of reproductive physiology and cellular morphology in different species. PMID:28398834

  10. Analysing and correcting the differences between multi-source and multi-scale spatial remote sensing observations.

    PubMed

    Dong, Yingying; Luo, Ruisen; Feng, Haikuan; Wang, Jihua; Zhao, Jinling; Zhu, Yining; Yang, Guijun

    2014-01-01

    Differences exist among analysis results of agriculture monitoring and crop production based on remote sensing observations, which are obtained at different spatial scales from multiple remote sensors in same time period, and processed by same algorithms, models or methods. These differences can be mainly quantitatively described from three aspects, i.e. multiple remote sensing observations, crop parameters estimation models, and spatial scale effects of surface parameters. Our research proposed a new method to analyse and correct the differences between multi-source and multi-scale spatial remote sensing surface reflectance datasets, aiming to provide references for further studies in agricultural application with multiple remotely sensed observations from different sources. The new method was constructed on the basis of physical and mathematical properties of multi-source and multi-scale reflectance datasets. Theories of statistics were involved to extract statistical characteristics of multiple surface reflectance datasets, and further quantitatively analyse spatial variations of these characteristics at multiple spatial scales. Then, taking the surface reflectance at small spatial scale as the baseline data, theories of Gaussian distribution were selected for multiple surface reflectance datasets correction based on the above obtained physical characteristics and mathematical distribution properties, and their spatial variations. This proposed method was verified by two sets of multiple satellite images, which were obtained in two experimental fields located in Inner Mongolia and Beijing, China with different degrees of homogeneity of underlying surfaces. Experimental results indicate that differences of surface reflectance datasets at multiple spatial scales could be effectively corrected over non-homogeneous underlying surfaces, which provide database for further multi-source and multi-scale crop growth monitoring and yield prediction, and their corresponding

  11. Analysing and Correcting the Differences between Multi-Source and Multi-Scale Spatial Remote Sensing Observations

    PubMed Central

    Dong, Yingying; Luo, Ruisen; Feng, Haikuan; Wang, Jihua; Zhao, Jinling; Zhu, Yining; Yang, Guijun

    2014-01-01

    Differences exist among analysis results of agriculture monitoring and crop production based on remote sensing observations, which are obtained at different spatial scales from multiple remote sensors in same time period, and processed by same algorithms, models or methods. These differences can be mainly quantitatively described from three aspects, i.e. multiple remote sensing observations, crop parameters estimation models, and spatial scale effects of surface parameters. Our research proposed a new method to analyse and correct the differences between multi-source and multi-scale spatial remote sensing surface reflectance datasets, aiming to provide references for further studies in agricultural application with multiple remotely sensed observations from different sources. The new method was constructed on the basis of physical and mathematical properties of multi-source and multi-scale reflectance datasets. Theories of statistics were involved to extract statistical characteristics of multiple surface reflectance datasets, and further quantitatively analyse spatial variations of these characteristics at multiple spatial scales. Then, taking the surface reflectance at small spatial scale as the baseline data, theories of Gaussian distribution were selected for multiple surface reflectance datasets correction based on the above obtained physical characteristics and mathematical distribution properties, and their spatial variations. This proposed method was verified by two sets of multiple satellite images, which were obtained in two experimental fields located in Inner Mongolia and Beijing, China with different degrees of homogeneity of underlying surfaces. Experimental results indicate that differences of surface reflectance datasets at multiple spatial scales could be effectively corrected over non-homogeneous underlying surfaces, which provide database for further multi-source and multi-scale crop growth monitoring and yield prediction, and their corresponding

  12. Understanding observed and unobserved health care access and utilization disparities among US Latino adults.

    PubMed

    Vargas Bustamante, Arturo; Fang, Hai; Rizzo, John A; Ortega, Alexander N

    2009-10-01

    This study hypothesizes that differences in health care access and utilization exist across Latino adults (>18 years), with U.S. Latino adults of Mexican ancestry demonstrating the worst patterns of access and utilization. The analyses use the National Health Interview Survey (NHIS) data from 1999 to 2007 (N = 33,908). The authors first estimate the disparities in health care access and utilization among different categories of Latinos. They also implement Blinder-Oaxaca techniques to decompose disparities into observed and unobserved components, comparing Latinos of Mexican ancestry with non-Mexican Latinos. Latinos of Mexican ancestry consistently demonstrate lower health care access and utilization patterns than non-Mexican Latinos. Health insurance and region of residence were the most important factors that explained observable differences. In contrast, language and citizenship status were relatively unimportant. Although a significant share of these disparities may be explained by observed characteristics, disparities because of unobserved heterogeneity among the different Latino cohorts are also considerable.

  13. Gaze stability of observers watching Op Art pictures.

    PubMed

    Zanker, Johannes M; Doyle, Melanie; Robin, Walker

    2003-01-01

    It has been the matter of some debate why we can experience vivid dynamic illusions when looking at static pictures composed from simple black and white patterns. The impression of illusory motion is particularly strong when viewing some of the works of 'Op Artists, such as Bridget Riley's painting Fall. Explanations of the illusory motion have ranged from retinal to cortical mechanisms, and an important role has been attributed to eye movements. To assess the possible contribution of eye movements to the illusory-motion percept we studied the strength of the illusion under different viewing conditions, and analysed the gaze stability of observers viewing the Riley painting and control patterns that do not produce the illusion. Whereas the illusion was reduced, but not abolished, when watching the painting through a pinhole, which reduces the effects of accommodation, it was not perceived in flash afterimages, suggesting an important role for eye movements in generating the illusion for this image. Recordings of eye movements revealed an abundance of small involuntary saccades when looking at the Riley pattern, despite the fact that gaze was kept within the dedicated fixation region. The frequency and particular characteristics of these rapid eye movements can vary considerably between different observers, but, although there was a tendency for gaze stability to deteriorate while viewing a Riley painting, there was no significant difference in saccade frequency between the stimulus and control patterns. Theoretical considerations indicate that such small image displacements can generate patterns of motion signals in a motion-detector network, which may serve as a simple and sufficient, but not necessarily exclusive, explanation for the illusion. Why such image displacements lead to perceptual results with a group of Op Art and similar patterns, but remain invisible for other stimuli, is discussed.

  14. Observation and difference analysis of carbon fluxes in different types of soil in Tianjin coastal zone

    NASA Astrophysics Data System (ADS)

    Li, Ya-Juan; Wang, Ting-Feng; Mao, Tian-Yu

    2018-02-01

    Tianjin Coastal Zone is located in the coastal area of the Bohai Sea, belonging to the typical coastal wetland, with high carbon value. Over the past decade the development of great intensity, there are obvious characteristics of artificial influence. This study focuses on observing the carbon fluxes of different soil types in the coastal area under strong artificial disturbance, summarizing the carbon sink calculation formula according to the soil type, and analyzing the main influencing factors affecting the carbon flux. The results show that there are representative intertidal zones in Tianjin, and the respiration of soil and secondary soil are different. The main influencing factors are soil surface temperature or air temperature. Coastal zones with different ecosystems can basically establish the relationship between temperature and soil carbon flux. (R2 = 0.5990), the relationship between artificial backfill is Q = 0.2061 - 0.2129T - 0.0391T2 (R2 = 0.7469), and the artificial soil is restored by artificial soil and the herbaceous greening is carried out., The relationship is Q = -0.1019 + 0.0327T‧ (R2 = 0.6621), T-soil temperature, T’-air temperature. At the same temperature, soil carbon fluxes in shoal wetlands are generally stronger than artificial backfill, showing more carbon source emissions.

  15. Observations to information

    NASA Astrophysics Data System (ADS)

    Cox, S. J.

    2013-12-01

    Observations provide the fundamental constraint on natural science interpretations. Earth science observations originate in many contexts, including in-situ field observations and monitoring, various modes of remote sensing and geophysics, sampling for ex-situ (laboratory) analysis, as well as numerical modelling and simulation which also provide estimates of parameter values. Most investigations require a combination of these, often sourced from multiple initiatives and archives, so data discovery and re-organization can be a significant project burden. The Observations and Measurements (O&M) information model was developed to provide a common vocabulary that can be applied to all these cases, and thus provide a basis for cross-initiative and cross-domain interoperability. O&M was designed in the context of the standards for geographic information from OGC and ISO. It provides a complementary viewpoint to the well-known feature (object oriented) and coverage (property field) views, but prioritizes the property determination process. Nevertheless, use of O&M implies the existence of well defined feature types. In disciplines such as geology and ecosystem sciences the primary complexity is in their model of the world, for which the description of each item requires access to diverse observation sets. On the other hand, geophysics and earth observations work with simpler underlying information items, but in larger quantities over multiple spatio-temporal dimensions, acquired using complex sensor systems. Multiple transformations between the three viewpoints are involved in the data flows in most investigations, from collection through analysis to information and story. The O&M model classifies observations: - from a provider viewpoint: in terms of the sensor or procedure involved; - from a consumer viewpoint: in terms of the property being reported, and the feature with which it is associated. These concerns carry different weights in different applications

  16. The Tropopause Inversion Layer: New Observations, New Theories

    NASA Astrophysics Data System (ADS)

    Tandon, N.; Randel, W. J.; Pan, L.; Son, S.; Polvani, L. M.

    2009-12-01

    There is now great interest in the tropopause inversion inversion layer (TIL), a 1-2 km region just above the tropopause where there is a spike in static stability. Radio occultation data from the COSMIC GPS mission are providing an unprecedented level of spatial and temporal resolution with which to analyze the TIL. We start by showing the agreement between GPS data and radiosondes. We then examine the causes and consequences of the TIL. Observations from the ACE satellite and fixed dynamical heating calculations suggest strong roles for water vapor and ozone in the formation and modulation of the TIL. This agrees with observations showing a large TIL in the polar winter, where water vapor levels are persistently high. It is also clear that TIL strength is related to vorticity, but observations and models have important differences that need to be reconciled. These dynamical considerations dovetail with observations showing high TIL variability in the storm-track regions. Finally there is evidence from ozonesonde data that the TIL may be coupled to transport across the tropopause.

  17. Measurement Error Correction Formula for Cluster-Level Group Differences in Cluster Randomized and Observational Studies

    ERIC Educational Resources Information Center

    Cho, Sun-Joo; Preacher, Kristopher J.

    2016-01-01

    Multilevel modeling (MLM) is frequently used to detect cluster-level group differences in cluster randomized trial and observational studies. Group differences on the outcomes (posttest scores) are detected by controlling for the covariate (pretest scores) as a proxy variable for unobserved factors that predict future attributes. The pretest and…

  18. A Puzzle Unsolved: Failure to Observe Different Effects of God and Religion Primes on Intergroup Attitudes

    PubMed Central

    Ramsay, Jonathan E.; Tong, Eddie M. W.; Pang, Joyce S.; Chowdhury, Avijit

    2016-01-01

    Religious priming has been found to have both positive and negative consequences, and recent research suggests that the activation of God-related and community-related religious cognitions may cause outgroup prosociality and outgroup derogation respectively. The present research sought to examine whether reminders of God and religion have different effects on attitudes towards ingroup and outgroup members. Over two studies, little evidence was found for different effects of these two types of religious primes. In study 1, individuals primed with the words “religion”, “God” and a neutral control word evaluated both ingroup and outgroup members similarly, although a marginal tendency towards more negative evaluations of outgroup members by females exposed to religion primes was observed. In study 2, no significant differences in attitudes towards an outgroup member were observed between the God, religion, and neutral priming conditions. Furthermore, the gender effect observed in study 1 did not replicate in this second study. Possible explanations for these null effects are discussed. PMID:26812526

  19. A Puzzle Unsolved: Failure to Observe Different Effects of God and Religion Primes on Intergroup Attitudes.

    PubMed

    Ramsay, Jonathan E; Tong, Eddie M W; Pang, Joyce S; Chowdhury, Avijit

    2016-01-01

    Religious priming has been found to have both positive and negative consequences, and recent research suggests that the activation of God-related and community-related religious cognitions may cause outgroup prosociality and outgroup derogation respectively. The present research sought to examine whether reminders of God and religion have different effects on attitudes towards ingroup and outgroup members. Over two studies, little evidence was found for different effects of these two types of religious primes. In study 1, individuals primed with the words "religion", "God" and a neutral control word evaluated both ingroup and outgroup members similarly, although a marginal tendency towards more negative evaluations of outgroup members by females exposed to religion primes was observed. In study 2, no significant differences in attitudes towards an outgroup member were observed between the God, religion, and neutral priming conditions. Furthermore, the gender effect observed in study 1 did not replicate in this second study. Possible explanations for these null effects are discussed.

  20. Power considerations for λ inflation factor in meta-analyses of genome-wide association studies.

    PubMed

    Georgiopoulos, Georgios; Evangelou, Evangelos

    2016-05-19

    The genomic control (GC) approach is extensively used to effectively control false positive signals due to population stratification in genome-wide association studies (GWAS). However, GC affects the statistical power of GWAS. The loss of power depends on the magnitude of the inflation factor (λ) that is used for GC. We simulated meta-analyses of different GWAS. Minor allele frequency (MAF) ranged from 0·001 to 0·5 and λ was sampled from two scenarios: (i) random scenario (empirically-derived distribution of real λ values) and (ii) selected scenario from simulation parameter modification. Adjustment for λ was considered under single correction (within study corrected standard errors) and double correction (additional λ corrected summary estimate). MAF was a pivotal determinant of observed power. In random λ scenario, double correction induced a symmetric power reduction in comparison to single correction. For MAF 1·2 and MAF >5%. Our results provide a quick but detailed index for power considerations of future meta-analyses of GWAS that enables a more flexible design from early steps based on the number of studies accumulated in different groups and the λ values observed in the single studies.

  1. Considerations on automation of coating machines

    NASA Astrophysics Data System (ADS)

    Tilsch, Markus K.; O'Donnell, Michael S.

    2015-04-01

    Most deposition chambers sold into the optical coating market today are outfitted with an automated control system. We surveyed several of the larger equipment providers, and nine of them responded with information about their hardware architecture, data logging, level of automation, error handling, user interface, and interfacing options. In this paper, we present a summary of the results of the survey and describe commonalities and differences together with some considerations of tradeoffs, such as between capability for high customization and simplicity of operation.

  2. Effects of different drivers on ion fluxes at Mars. MARS EXPRESS and MAVEN observations

    NASA Astrophysics Data System (ADS)

    Dubinin, Eduard; Fraenz, Markus; McFadden, James; Halekas, Jasper; Epavier, Frank; Connerney, Jack; Brain, David; Jakosky, Bruce; Andrews, David; Barabash, Stas

    2017-04-01

    Recent observations by Mars Express and MAVEN spacecraft have shown that the Martian atmosphere/ionosphere is exposed to the impact of solar wind which results in losses of volatiles from Mars. This erosion is an important factor for the evolution of the Martian atmosphere and its water inventory. To estimate the escape forced by the solar wind during the early Solar System conditions we need to know how the ionosphere of Mars and escape fluxes depend on variations in the strength of the external drivers, in particularly, of solar wind and solar EUV flux. We present multi-instrument observations of the influence of the solar wind and solar irradiance on the Martian ionosphere and escape fluxes. We use data obtained by the ASPERA-3 and MARSIS experiments on Mars Express and by the STATIC, SWIA, MAG and EUV monitor on MAVEN. Observations by Mars Express supplemented by the EUV monitoring at Earth orbit and translated to Mars orbit provide us information about this dependence over more than 10 years whereas the measurements made by MAVEN provide us for the first time the opportunity to study these processes with simultaneous monitoring of the solar wind and ionospheric variations, planetary ion fluxes and solar irradiance. It will be shown that that fluxes of planetary ions through different escape channels (trans-terminator fluxes, ion plume, plasma sheet) respond differently on the variations of the different drivers.

  3. Conflicting character distribution within different data sets on cardueline finches: artifact or history?

    PubMed

    Fehrer, J

    1996-01-01

    Cardueline finches (Passeriformes: Fringillidae, Carduelinae) provide an example of unresolved species relationships despite decades of extensive study of the group. Existing morphological studies suffer from numerous cases of assumed parallel evolution due to a conflicting character distribution in different lineages. In this study, results of assumed parallel evolution due to a conflicting character distribution in different lineages. In this study, results of cytochrome b sequence analysis are compared with species relationships suggested by morphological and behavioral evidence. In the molecular analyses, species clusters mutually excluding each other were observed, lowering the statistical support of the internodes, i.e., the branches could not be resolved convincingly. Despite these difficulties, some phylogenetic signal was present in the molecular data as well as in the other approaches. In particular, any species or genus relationship suggested by cytochrome b sequence analysis was reflected by some other evidence. Based on this general congruence of the different data sets and on a considerable cytochrome b tree stability observed independent of species combination, choice of outgroup and tree-generating method, the short internodes are interpreted to reflect a historical reality. A model of cardueline evolution is proposed which assumes a population of cardueline ancestors with considerable polymorphism concerning the mitochondrial DNA and morphological characters alike. Retention of ancestral character states in different lineages and a subsequent rapid radiation are suggested to explain the conflicting character distributions observed in different fields of investigation.

  4. Experimental Study of Multispectral Characteristics of an Unmanned Aerial Vehicle at Different Observation Angles

    PubMed Central

    Zheng, Haijing; Bai, Tingzhu; Wang, Quanxi; Cao, Fengmei; Shao, Long; Sun, Zhaotian

    2018-01-01

    This study investigates multispectral characteristics of an unmanned aerial vehicle (UAV) at different observation angles by experiment. The UAV and its engine are tested on the ground in the cruise state. Spectral radiation intensities at different observation angles are obtained in the infrared band of 0.9–15 μm by a spectral radiometer. Meanwhile, infrared images are captured separately by long-wavelength infrared (LWIR), mid-wavelength infrared (MWIR), and short-wavelength infrared (SWIR) cameras. Additionally, orientation maps of the radiation area and radiance are obtained. The results suggest that the spectral radiation intensity of the UAV is determined by its exhaust plume and that the main infrared emission bands occur at 2.7 μm and 4.3 μm. At observation angles in the range of 0°–90°, the radiation area of the UAV in MWIR band is greatest; however, at angles greater than 90°, the radiation area in the SWIR band is greatest. In addition, the radiance of the UAV at an angle of 0° is strongest. These conclusions can guide IR stealth technique development for UAVs. PMID:29389880

  5. Implementation Considerations, Not Topological Differences, Are the Main Determinants of Noise Suppression Properties in Feedback and Incoherent Feedforward Circuits

    PubMed Central

    Buzi, Gentian; Khammash, Mustafa

    2016-01-01

    Biological systems use a variety of mechanisms to deal with the uncertain nature of their external and internal environments. Two of the most common motifs employed for this purpose are the incoherent feedforward (IFF) and feedback (FB) topologies. Many theoretical and experimental studies suggest that these circuits play very different roles in providing robustness to uncertainty in the cellular environment. Here, we use a control theoretic approach to analyze two common FB and IFF architectures that make use of an intermediary species to achieve regulation. We show the equivalence of both circuits topologies in suppressing static cell-to-cell variations. While both circuits can suppress variations due to input noise, they are ineffective in suppressing inherent chemical reaction stochasticity. Indeed, these circuits realize comparable improvements limited to a modest 25% variance reduction in best case scenarios. Such limitations are attributed to the use of intermediary species in regulation, and as such, they persist even for circuit architectures that combine both IFF and FB features. Intriguingly, while the FB circuits are better suited in dealing with dynamic input variability, the most significant difference between the two topologies lies not in the structural features of the circuits, but in their practical implementation considerations. PMID:27257684

  6. Implementation Considerations, Not Topological Differences, Are the Main Determinants of Noise Suppression Properties in Feedback and Incoherent Feedforward Circuits.

    PubMed

    Buzi, Gentian; Khammash, Mustafa

    2016-06-01

    Biological systems use a variety of mechanisms to deal with the uncertain nature of their external and internal environments. Two of the most common motifs employed for this purpose are the incoherent feedforward (IFF) and feedback (FB) topologies. Many theoretical and experimental studies suggest that these circuits play very different roles in providing robustness to uncertainty in the cellular environment. Here, we use a control theoretic approach to analyze two common FB and IFF architectures that make use of an intermediary species to achieve regulation. We show the equivalence of both circuits topologies in suppressing static cell-to-cell variations. While both circuits can suppress variations due to input noise, they are ineffective in suppressing inherent chemical reaction stochasticity. Indeed, these circuits realize comparable improvements limited to a modest 25% variance reduction in best case scenarios. Such limitations are attributed to the use of intermediary species in regulation, and as such, they persist even for circuit architectures that combine both IFF and FB features. Intriguingly, while the FB circuits are better suited in dealing with dynamic input variability, the most significant difference between the two topologies lies not in the structural features of the circuits, but in their practical implementation considerations.

  7. Observation, Serendipity, and Climatic Change

    ERIC Educational Resources Information Center

    Schaefer, Vincent J.

    1974-01-01

    Provides an illustration of the contribution of serendipitous happenings to scientific information and relates this to a consideration of social and technical problems confronting mankind. The author decries an unfortunate tendency in science today: that of discarding observational aspects of field activities which cannot easily be made…

  8. Full 2D observation of water surface elevation from SWOT under different flow conditions

    NASA Astrophysics Data System (ADS)

    Domeneghetti, Alessio; Schumann, Guy; Rui, Wei; Durand, Michael; Pavelsky, Tamlin

    2016-04-01

    The upcoming Surface Water and Ocean Topography (SWOT) satellite mission is a joint project of NASA, Centre National d'Etudes Spatiales (CNES, France), the Canadian Space Agency, and the Space Agency of the UK that will provide a first global, high-resolution observation of ocean and terrestrial water surface heights. Characterized by an observation swath of 120 km and an orbit repeat interval of about 21 days, SWOT will provide unprecedented bi-dimensional observations of rivers wider than 50-100 m. Despite many research activities that have investigated potential uses of remotely sensed data from SWOT, potentials and limitations of the spatial observations provided by the satellite mission for flood modeling still remain poorly understood and investigated. In this study we present a first analysis of the spatial observation of water surface elevation that is expected from SWOT for a 140 km reach of the middle-lower portion of the Po River, in Northern Italy. The river stretch is characterized by a main channel varying from 200-500 m in width and a floodplain that can be as wide as 5 km and that is delimited by a system of major embankments. The reconstruction of the hydraulic behavior of the Po River is performed by means of a quasi-2d model built with detailed topographic and bathymetric information (LiDAR, 2 m resolution), while the simulation of the spatial observation sensed by SWOT is performed with a SWOT simulator that mimics the satellite sensor characteristics. Referring to water surface elevations associated with different flow conditions (maximum, minimum and average flow reproduced by means of the quasi-2d numerical model) this work provides a first characterization of the spatial observations provided by SWOT and highlights the strengths and limitations of the expected products. By referring to a real river reach the analysis provides a credible example of the type of spatial observations that will be available after launch of SWOT and offers a first

  9. Spatial frequency characteristics at image decision-point locations for observers with different radiological backgrounds in lung nodule detection

    NASA Astrophysics Data System (ADS)

    Pietrzyk, Mariusz W.; Manning, David J.; Dix, Alan; Donovan, Tim

    2009-02-01

    Aim: The goal of the study is to determine the spatial frequency characteristics at locations in the image of overt and covert observers' decisions and find out if there are any similarities in different observers' groups: the same radiological experience group or the same accuracy scored level. Background: The radiological task is described as a visual searching decision making procedure involving visual perception and cognitive processing. Humans perceive the world through a number of spatial frequency channels, each sensitive to visual information carried by different spatial frequency ranges and orientations. Recent studies have shown that particular physical properties of local and global image-based elements are correlated with the performance and the level of experience of human observers in breast cancer and lung nodule detections. Neurological findings in visual perception were an inspiration for wavelet applications in vision research because the methodology tries to mimic the brain processing algorithms. Methods: The wavelet approach to the set of postero-anterior chest radiographs analysis has been used to characterize perceptual preferences observers with different levels of experience in the radiological task. Psychophysical methodology has been applied to track eye movements over the image, where particular ROIs related to the observers' fixation clusters has been analysed in the spaces frame by Daubechies functions. Results: Significance differences have been found between the spatial frequency characteristics at the location of different decisions.

  10. Combining the Observations from Different GNSS (Invited)

    NASA Astrophysics Data System (ADS)

    Dach, R.; Lutz, S.; Schaer, S.; Bock, H.; Jäggi, A.; Meindl, M.; Ostini, L.; Thaller, D.; Steinbach, A.; Beutler, G.; Steigenberger, P.

    2009-12-01

    corrections. The procedure to derive the satellite and receiver clock corrections is under the transition from the currently operational GPS-only to the multi-GNSS mode including GPS and GLONASS. When CODE started with its multi-GNSS processing more than 6 years ago the network density and the number of active GLONASS satellites was very limited. Nowadays this situation has changed, which brings us into the position to review the strategy to combine the measurements from different GNSS in the data analysis. The presentation will discuss the advantages and disadvantages of the highest (only one constant inter-system bias) and lowest (a minimum number of common parameters) possible correlation between the observations of the individual GNSS.

  11. Formulary Selection Criteria for Biosimilars: Considerations for US Health-System Pharmacists.

    PubMed

    Griffith, Niesha; McBride, Ali; Stevenson, James G; Green, Larry

    2014-10-01

    Pharmacists will play a key role in evaluating biosimilars for formulary inclusion in the United States. As defined by US law, a biosimilar is a biologic that is highly similar to its reference product, notwithstanding minor differences in clinically inactive components, and should not have clinically meaningful differences from its reference product in safety, purity, and potency. We review biosimilars and the current European Union and US regulatory pathways for biosimilars. Furthermore, we propose a checklist of considerations to ensure that US pharmacists thoroughly evaluate future biosimilars for formulary inclusion. Included in the checklist are considerations related to the availability of preapproval and postapproval safety and efficacy data; differences in product characteristics and immunogenicity between the biosimilar and reference product; manufacturer-related parameters that can affect a reliable supply of quality products; health-system and patient perspectives on product packaging, labeling, storage, and administration; costs and insurance coverage; patient education; interchangeability and differences in the range of indications; and evaluation of institutions' information technology systems.

  12. How do Danish community pharmacies vary in engaging customers in medicine dialogues at the counter - an observational study.

    PubMed

    Kaae, Susanne; Saleem, Sahdia; Kristiansen, Maria

    2014-07-01

    Counter counseling is an important part of community pharmacies service delivery. Difficulties arise because customers appear less interested than the staff in discussing their medicine. It is unclear how individual pharmacies differ with regard to overcoming these obstacles. This study explores differences in the communication practices of pharmacies with regard to engaging customers in medicine dialogues. The work of Stevenson et al. describing five types of interaction scenarios at the counter was used for structured overt non-participant observations of 100 encounters in each of five Danish pharmacies. Variation in pharmacies success in engaging customers in medicine dialogues were calculated using descriptive statistics, and the statistical significance of observed differences across pharmacies was analyzed using odds ratios (OR). Considerable differences between the pharmacies were identified. Differences exist in how often pharmacy staff attempts to encourage customers to participate in medication dialogues and how often they succeed. The pharmacies serving the most customers per day were the most successful. A possible link between a low number of refill customers offered counseling and 'success rate' was identified. The pharmacies showed considerable variation in attempts to engage customers in medication dialogues at the counter and success in doing so. The reasons for the identified patterns are unclear.

  13. A Different View on the Checkerboard? Alterations in Early and Late Visually Evoked EEG Potentials in Asperger Observers

    PubMed Central

    Kornmeier, Juergen; Wörner, Rike; Riedel, Andreas; Bach, Michael; Tebartz van Elst, Ludger

    2014-01-01

    Background Asperger Autism is a lifelong psychiatric condition with highly circumscribed interests and routines, problems in social cognition, verbal and nonverbal communication, and also perceptual abnormalities with sensory hypersensitivity. To objectify both lower-level visual and cognitive alterations we looked for differences in visual event-related potentials (EEG) between Asperger observers and matched controls while they observed simple checkerboard stimuli. Methods In a balanced oddball paradigm checkerboards of two checksizes (0.6° and 1.2°) were presented with different frequencies. Participants counted the occurrence times of the rare fine or rare coarse checkerboards in different experimental conditions. We focused on early visual ERP differences as a function of checkerboard size and the classical P3b ERP component as an indicator of cognitive processing. Results We found an early (100–200 ms after stimulus onset) occipital ERP effect of checkerboard size (dominant spatial frequency). This effect was weaker in the Asperger than in the control observers. Further a typical parietal/central oddball-P3b occurred at 500 ms with the rare checkerboards. The P3b showed a right-hemispheric lateralization, which was more prominent in Asperger than in control observers. Discussion The difference in the early occipital ERP effect between the two groups may be a physiological marker of differences in the processing of small visual details in Asperger observers compared to normal controls. The stronger lateralization of the P3b in Asperger observers may indicate a stronger involvement of the right-hemispheric network of bottom-up attention. The lateralization of the P3b signal might be a compensatory consequence of the compromised early checksize effect. Higher-level analytical information processing units may need to compensate for difficulties in low-level signal analysis. PMID:24632708

  14. A different view on the checkerboard? Alterations in early and late visually evoked EEG potentials in Asperger observers.

    PubMed

    Kornmeier, Juergen; Wörner, Rike; Riedel, Andreas; Bach, Michael; Tebartz van Elst, Ludger

    2014-01-01

    Asperger Autism is a lifelong psychiatric condition with highly circumscribed interests and routines, problems in social cognition, verbal and nonverbal communication, and also perceptual abnormalities with sensory hypersensitivity. To objectify both lower-level visual and cognitive alterations we looked for differences in visual event-related potentials (EEG) between Asperger observers and matched controls while they observed simple checkerboard stimuli. In a balanced oddball paradigm checkerboards of two checksizes (0.6° and 1.2°) were presented with different frequencies. Participants counted the occurrence times of the rare fine or rare coarse checkerboards in different experimental conditions. We focused on early visual ERP differences as a function of checkerboard size and the classical P3b ERP component as an indicator of cognitive processing. We found an early (100-200 ms after stimulus onset) occipital ERP effect of checkerboard size (dominant spatial frequency). This effect was weaker in the Asperger than in the control observers. Further a typical parietal/central oddball-P3b occurred at 500 ms with the rare checkerboards. The P3b showed a right-hemispheric lateralization, which was more prominent in Asperger than in control observers. The difference in the early occipital ERP effect between the two groups may be a physiological marker of differences in the processing of small visual details in Asperger observers compared to normal controls. The stronger lateralization of the P3b in Asperger observers may indicate a stronger involvement of the right-hemispheric network of bottom-up attention. The lateralization of the P3b signal might be a compensatory consequence of the compromised early checksize effect. Higher-level analytical information processing units may need to compensate for difficulties in low-level signal analysis.

  15. Basics of compounding sterile preparations: nomenclature and considerations.

    PubMed

    Allen, Loyd V

    2014-01-01

    This article focuses on sterile dosage forms and serves as a review for those trained in compounding sterile preparations, as well as to educate those that have not received any formal training on the topics of nomenclature and composition. The use of proper terminology is important for proper/accurate communications among healthcare practitioners. Proper terminology also has potential legal/liability implications. In addition to terminology considerations, it is important to be aware of the different routes of administration of sterile formulations and their different compositions and uses.

  16. Multiple Integrated Examinations: An Observational Study of Different Academic Curricula Based on a Business Administration Assessment

    ERIC Educational Resources Information Center

    Ardolino, Piermatteo; Noventa, Stefano; Formicuzzi, Maddalena; Cubico, Serena; Favretto, Giuseppe

    2016-01-01

    An observational study has been carried out to analyse differences in performance between students of different undergraduate curricula in the same written business administration examination, focusing particularly on possible effects of "integrated" or "multi-modular" examinations, a recently widespread format in Italian…

  17. Individual Differences in Language Acquisition and Processing.

    PubMed

    Kidd, Evan; Donnelly, Seamus; Christiansen, Morten H

    2018-02-01

    Humans differ in innumerable ways, with considerable variation observable at every level of description, from the molecular to the social. Traditionally, linguistic and psycholinguistic theory has downplayed the possibility of meaningful differences in language across individuals. However, it is becoming increasingly evident that there is significant variation among speakers at any age as well as across the lifespan. Here, we review recent research in psycholinguistics, and argue that a focus on individual differences (IDs) provides a crucial source of evidence that bears strongly upon core issues in theories of the acquisition and processing of language; specifically, the role of experience in language acquisition, processing, and attainment, and the architecture of the language system. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Controllability and observability of Boolean networks arising from biology

    NASA Astrophysics Data System (ADS)

    Li, Rui; Yang, Meng; Chu, Tianguang

    2015-02-01

    Boolean networks are currently receiving considerable attention as a computational scheme for system level analysis and modeling of biological systems. Studying control-related problems in Boolean networks may reveal new insights into the intrinsic control in complex biological systems and enable us to develop strategies for manipulating biological systems using exogenous inputs. This paper considers controllability and observability of Boolean biological networks. We propose a new approach, which draws from the rich theory of symbolic computation, to solve the problems. Consequently, simple necessary and sufficient conditions for reachability, controllability, and observability are obtained, and algorithmic tests for controllability and observability which are based on the Gröbner basis method are presented. As practical applications, we apply the proposed approach to several different biological systems, namely, the mammalian cell-cycle network, the T-cell activation network, the large granular lymphocyte survival signaling network, and the Drosophila segment polarity network, gaining novel insights into the control and/or monitoring of the specific biological systems.

  19. Minimum clinically important differences in chronic pain vary considerable by baseline pain and methodological factors: systematic review of empirical studies.

    PubMed

    Frahm Olsen, Mette; Bjerre, Eik; Hansen, Maria Damkjær; Tendal, Britta; Hilden, Jørgen; Hróbjartsson, Asbjørn

    2018-05-21

    The minimum clinically important difference (MCID) is used to interpret the relevance of treatment effects, e.g., when developing clinical guidelines, evaluating trial results or planning sample sizes. There is currently no agreement on an appropriate MCID in chronic pain and little is known about which contextual factors cause variation. This is a systematic review. We searched PubMed, EMBASE, and Cochrane Library. Eligible studies determined MCID for chronic pain based on a one-dimensional pain scale, a patient-reported transition scale of perceived improvement, and either a mean change analysis (mean difference in pain among minimally improved patients) or a threshold analysis (pain reduction associated with best sensitivity and specificity for identifying minimally improved patients). Main results were descriptively summarized due to considerable heterogeneity, which were quantified using meta-analyses and explored using subgroup analyses and metaregression. We included 66 studies (31.254 patients). Median absolute MCID was 23 mm on a 0-100 mm scale (interquartile range [IQR] 12-39) and median relative MCID was 34% (IQR 22-45) among studies using the mean change approach. In both cases, heterogeneity was very high: absolute MCID I 2  = 99% and relative MCID I 2  = 96%. High variation was also seen among studies using the threshold approach: median absolute MCID was 20 mm (IQR 15-30) and relative MCID was 32% (IQR 15-41). Absolute MCID was strongly associated with baseline pain, explaining approximately two-thirds of the variation, and to a lesser degree with the operational definition of minimum pain relief and clinical condition. A total of 15 clinical and methodological factors were assessed as possible causes for variation in MCID. MCID for chronic pain relief vary considerably. Baseline pain is strongly associated with absolute, but not relative, measures. To a much lesser degree, MCID is also influenced by the operational definition of relevant pain

  20. [Effect of different oxygen tension on the cytoskeleton remodeling of goat temporomandibular joint disc cells].

    PubMed

    Xiaolan, He; Guangjie, Bao; Linglu, Sun; Xue, Zhang; Shanying, Bao; Hong, Kang

    2017-08-01

    Objective The effect of different oxygen tensions on the cytoskeleton remodeling of goat temporomandibular joint (TMJ) disc cells were investigated. Methods Goat TMJ disc cells were cultured under normoxia (21% O₂) and hypoxia (2%, 4%, and 8% O₂). Toluidine blue, picrosirius red, and type Ⅰ collagen immunocytochemical staining were performed to observe the changes in cell phenotype under different oxygen levels. Immunofluorescent staining and real-time reverse transcription-polymerase chain reaction analysis were then performed to identify actin, tubulin, and vimentin in the cultured disc cells. Results TMJ disc cells still displayed fibroblast characteristics under different oxygen levels and their cytoskeletons had regular arrangement. The fluorescence intensities of actin and vimentin were lowest at 4% O₂(P<0.05), whereas that of tubulin was highest at 2% O₂ (P<0.05). No significant difference among the other groups was observed (P>0.05). Actin mRNA levels were considerably decreased at 2% O₂ and 4% O₂ in hypoxic conditions, while actin mRNA expression was highest in 21% O₂. Tubulin mRNA levels considerably increased at 2% O₂, while tubulin mRNA expression was lowest in 8% O₂ (P<0.05). Vimentin mRNA expression was lowest at 4% O₂ and highest at 21% O₂, and significant differences were observed between vimentin mRNA expression levels among these oxygen levels (P<0.05). Conclusion Cytoskeletons were reconstructed in different oxygen tensions, and 2% O₂ may be the optimal oxygen level required to proliferate TMJ disc cells.

  1. Access to Full-Text Journal Articles: Some Practical Considerations.

    ERIC Educational Resources Information Center

    Racine, Drew

    1992-01-01

    Discusses some of the issues and problems involved in using electronic full-text journals in the University of Texas at Austin libraries. Issues addressed include different standards; subjects represented and the time period covered; hardware considerations; software; printing; skills and training needed for library staff and for users; and costs.…

  2. Ethical Considerations in Technology Transfer.

    ERIC Educational Resources Information Center

    Froehlich, Thomas J.

    1991-01-01

    Examines ethical considerations involved in the transfer of appropriate information technology to less developed countries. Approaches to technology are considered; two philosophical frameworks for studying ethical considerations are discussed, i.e., the Kantian approach and the utilitarian perspective by John Stuart Mill; and integration of the…

  3. Development Considerations for Nanocrystal Drug Products.

    PubMed

    Chen, Mei-Ling; John, Mathew; Lee, Sau L; Tyner, Katherine M

    2017-05-01

    Nanocrystal technology has emerged as a valuable tool for facilitating the delivery of poorly water-soluble active pharmaceutical ingredients (APIs) and enhancing API bioavailability. To date, the US Food and Drug Administration (FDA) has received over 80 applications for drug products containing nanocrystals. These products can be delivered by different routes of administration and are used in a variety of therapeutic areas. To aid in identifying key developmental considerations for these products, a retrospective analysis was performed on the submissions received by the FDA to date. Over 60% of the submissions were for the oral route of administration. Based on the Biopharmaceutics Classification System (BCS), most nanocrystal drugs submitted to the FDA are class II compounds that possess low aqueous solubility and high intestinal permeability. Impact of food on drug bioavailability was reduced for most nanocrystal formulations as compared with their micronized counterparts. For all routes of administration, dose proportionality was observed for some, but not all, nanocrystal products. Particular emphasis in the development of nanocrystal products was placed on the in-process tests and controls at critical manufacturing steps (such as milling process), mitigation and control of process-related impurities, and the stability of APIs or polymorphic form (s) during manufacturing and upon storage. This emphasis resulted in identifying challenges to the development of these products including accurate determination of particle size (distribution) of drug substance and/or nanocrystal colloidal dispersion, identification of polymorphic form (s), and establishment of drug substance/product specifications.

  4. Temporal framing and the decision to take part in type 2 diabetes screening: effects of individual differences in consideration of future consequences on persuasion.

    PubMed

    Orbell, Sheina; Hagger, Martin

    2006-07-01

    Reliable individual differences in the extent to which people consider the long- and short-term consequences of their own behaviors are hypothesized to influence the impact of a persuasive communication. In a field experiment, the time frame of occurrence of positive and negative consequences of taking part in a proposed Type 2 diabetes screening program was manipulated in a sample of 210 adults with a mean age of 53 years. Individual differences in consideration of future consequences (CFC; A. Strathman, F. Gleicher, D. S. Boninger, & C. S. Edwards, 1994) moderated (a) the generation of positive and negative thoughts and (b) the persuasive impact of the different communications. Low-CFC individuals were more persuaded when positive consequences were short term and negative consequences were long term. The opposite was true of high-CFC individuals. Path analyses show that net positive thoughts generated mediated the effect of the CFC x Time Frame manipulations on behavioral intentions.

  5. How do Danish community pharmacies vary in engaging customers in medicine dialogues at the counter – an observational study

    PubMed Central

    Kaae, Susanne; Saleem, Sahdia; Kristiansen, Maria

    2014-01-01

    Background Counter counseling is an important part of community pharmacies service delivery. Difficulties arise because customers appear less interested than the staff in discussing their medicine. It is unclear how individual pharmacies differ with regard to overcoming these obstacles. Objective This study explores differences in the communication practices of pharmacies with regard to engaging customers in medicine dialogues. Methods The work of Stevenson et al. describing five types of interaction scenarios at the counter was used for structured overt non-participant observations of 100 encounters in each of five Danish pharmacies. Variation in pharmacies success in engaging customers in medicine dialogues were calculated using descriptive statistics, and the statistical significance of observed differences across pharmacies was analyzed using odds ratios (OR). Results Considerable differences between the pharmacies were identified. Differences exist in how often pharmacy staff attempts to encourage customers to participate in medication dialogues and how often they succeed. The pharmacies serving the most customers per day were the most successful. A possible link between a low number of refill customers offered counseling and ‘success rate’ was identified. Conclusions The pharmacies showed considerable variation in attempts to engage customers in medication dialogues at the counter and success in doing so. The reasons for the identified patterns are unclear. PMID:25243031

  6. Ethnic Differences in Nonverbal Pain Behaviors Observed in Older Adults with Dementia.

    PubMed

    Ford, Brianne; Snow, A Lynn; Herr, Keela; Tripp-Reimer, Toni

    2015-10-01

    Research supports using nonverbal pain behaviors to identify pain in persons with dementia. It is unknown whether variations exist among ethnic groups in the expression of nonverbal pain behaviors in this special population. The purpose of this descriptive study was to examine ethnic differences in the presentation and intensity of nonverbal pain behaviors among African American, Caucasian, and Hispanic older adults with dementia when screened for pain by certified nursing assistants. Six certified nursing assistants were trained to review and score 28 video recordings of subjects with dementia for nonverbal pain behaviors using the Non-Communicative Patient's Pain Assessment Instrument. Chi-square was used to examine differences among ethnic groups with regard to the display of nonverbal pain behaviors, and ANOVA was used to evaluate differences in the intensity of overall pain across ethnic groups. Of the 168 assessments, pain words (28%), pain noises (29.8%), and pain faces (28%) were observed most often as indicators of pain. Rubbing, bracing, and restlessness were rarely noted. Chi-square analysis revealed ethnic differences in the expression of pain words (χ(2) = 19.167, p < .001). No significant differences were noted across ethnic groups with regards to overall pain intensity. These findings are the first to examine ethnic differences in nonverbal pain behaviors for older adults with dementia. However, future work should examine assessment tendencies of providers in a larger, more diverse sample. Copyright © 2015 American Society for Pain Management Nursing. All rights reserved.

  7. 32 CFR 643.53 - Consideration.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., the consideration for a lease of real estate will be the appraised fair market rental value. However, the value of the maintenance, protection, repair, or restoration by the lessee of the property leased... all or part of the consideration. The value of the maintenance, protection, repair or restoration...

  8. 32 CFR 643.53 - Consideration.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., the consideration for a lease of real estate will be the appraised fair market rental value. However, the value of the maintenance, protection, repair, or restoration by the lessee of the property leased... all or part of the consideration. The value of the maintenance, protection, repair or restoration...

  9. Evaluation of Xerostomia in Different Psychological Disorders: An Observational Study

    PubMed Central

    Chandrappa, Pramod Redder; Patil, Snehal; Roodmal, Seema Yadav; Kumarswamy, Akshay; Chappi, Mounesh Kumar

    2016-01-01

    Introduction Psychiatric diseases like anxiety, depression, schizophrenia and bipolar disorders are increasing at an alarming rate. These diseases can affect the quantity and quality of saliva leading to multiple oral diseases. Although many researchers have evaluated xerostomia in general population, its prevalence is not been assessed in patients suffering from different psychological disorders. Aim To investigate the prevalence of xerostomia and to assess the correlation between xerostomia and dryness of lip and mucosa in different psychological disorders. Materials and Methods A cross-sectional observational study was conducted over a period of six months in Department of Psychiatry and Department of Oral Medicine. Patients with anxiety, depression, schizophrenia and bipolar disorder, as diagnosed by an experienced psychiatrist, were given a questionnaire to evaluate the xerostomia. Patients with symptoms of xerostomia were subjected to oral examination by a skilled oral diagnostician to check for dryness of lips and mucosa. One hundred patients from each group of psychiatric diseases were included in the study using a consecutive sampling technique. An equal number of healthy individuals reporting to oral medicine department for routine oral screening were included as control group after initial psychiatric evaluation. Results In this study statistically significant increase in the xerostomia in psychiatric patients was recorded when compared to the control group (p<0.01). Xerostomia was significantly higher in anxiety patients (51%) followed by depression (47%), bipolar disorder (41%), schizophrenia (39%) and control group (27%). The majority of the psychiatric patients had ‘moderate’ to ‘severe’ xerostomia whereas the control group had ‘mild’ xerostomia. Xerostomia was significantly higher in younger age group (18–49 years) than in older age group and females patients had higher xerostomia than male patients. Psychiatric patients had

  10. Feasibility of observing small differences in friction mean effective pressure between different lubricating oil formations using small, single-cylinder motored engine rig

    DOE PAGES

    Rohr, William F.; Nguyen, Ke; Bunting, Bruce G.; ...

    2015-09-01

    Here, the feasibility of using a motored single-cylinder 517 cc diesel engine to observe small frictional differences between oil formulations is investigated. Friction mean effective pressure (FMEP) is measured and compared for an SAE 10W-30 and an SAE 5W-20 oil in three stages of production: base oil, commercial oil without a friction and wear reducing additive, and fully formulated commercial oil. In addition, a commercial SAE 5W-30 engine oil is investigated. Friction mean effective pressure is plotted versus oil dynamic viscosity to compare the lubricant FMEP at a given viscosity. Linear regressions and average friction mean effective pressure are usedmore » as a secondary means of comparing FMEP for the various oil formulations. Differences between the oils are observed with the base oil having higher friction at a given viscosity but a lower average FMEP due to the temperature distribution of the test and lower viscosities reached by the base oil. The commercial oil is shown to have both a higher FMEP at a given viscosity and a higher average FMEP than the commercial oil without a friction and wear reducing additive. The increase in friction for the oil without a friction and wear reduction additive indicates that the operational regime of the engine may be out of the bounds of the optimal regime for the additive or that the additive is more optimized for wear reduction. Results show that it is feasible to observe small differences in FMEP between lubricating oil formulations using a small, single-cylinder motored engine.« less

  11. Feasibility of observing small differences in friction mean effective pressure between different lubricating oil formations using small, single-cylinder motored engine rig

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rohr, William F.; Nguyen, Ke; Bunting, Bruce G.

    Here, the feasibility of using a motored single-cylinder 517 cc diesel engine to observe small frictional differences between oil formulations is investigated. Friction mean effective pressure (FMEP) is measured and compared for an SAE 10W-30 and an SAE 5W-20 oil in three stages of production: base oil, commercial oil without a friction and wear reducing additive, and fully formulated commercial oil. In addition, a commercial SAE 5W-30 engine oil is investigated. Friction mean effective pressure is plotted versus oil dynamic viscosity to compare the lubricant FMEP at a given viscosity. Linear regressions and average friction mean effective pressure are usedmore » as a secondary means of comparing FMEP for the various oil formulations. Differences between the oils are observed with the base oil having higher friction at a given viscosity but a lower average FMEP due to the temperature distribution of the test and lower viscosities reached by the base oil. The commercial oil is shown to have both a higher FMEP at a given viscosity and a higher average FMEP than the commercial oil without a friction and wear reducing additive. The increase in friction for the oil without a friction and wear reduction additive indicates that the operational regime of the engine may be out of the bounds of the optimal regime for the additive or that the additive is more optimized for wear reduction. Results show that it is feasible to observe small differences in FMEP between lubricating oil formulations using a small, single-cylinder motored engine.« less

  12. Considerations on the Use of 3-D Geophysical Models to Predict Test Ban Monitoring Observables

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Harris, D B; Zucca, J J; McCallen, D B

    2007-07-09

    The use of 3-D geophysical models to predict nuclear test ban monitoring observables (phase travel times, amplitudes, dispersion, etc.) is widely anticipated to provide improvements in the basic seismic monitoring functions of detection, association, location, discrimination and yield estimation. A number of questions arise when contemplating a transition from 1-D, 2-D and 2.5-D models to constructing and using 3-D models, among them: (1) Can a 3-D geophysical model or a collection of 3-D models provide measurably improved predictions of seismic monitoring observables over existing 1-D models, or 2-D and 2 1/2-D models currently under development? (2) Is a single modelmore » that can predict all observables achievable, or must separate models be devised for each observable? How should joint inversion of disparate observable data be performed, if required? (3) What are the options for model representation? Are multi-resolution models essential? How does representation affect the accuracy and speed of observable predictions? (4) How should model uncertainty be estimated, represented and how should it be used? Are stochastic models desirable? (5) What data types should be used to construct the models? What quality control regime should be established? (6) How will 3-D models be used in operations? Will significant improvements in the basic monitoring functions result from the use of 3-D models? Will the calculation of observables through 3-D models be fast enough for real-time use or must a strategy of pre-computation be employed? (7) What are the theoretical limits to 3-D model development (resolution, uncertainty) and performance in predicting monitoring observables? How closely can those limits be approached with projected data availability, station distribution and inverse methods? (8) What priorities should be placed on the acquisition of event ground truth information, deployment of new stations, development of new inverse techniques, exploitation of large

  13. Costs and cost-effectiveness of different DOT strategies for the treatment of tuberculosis in Pakistan. Directly Observed Treatment.

    PubMed

    Khan, M A; Walley, J D; Witter, S N; Imran, A; Safdar, N

    2002-06-01

    An economic study was conducted alongside a clinical trial at three sites in Pakistan to establish the costs and effectiveness of different strategies for implementing directly observed treatment (DOT) for tuberculosis. Patients were randomly allocated to one of three arms: DOTS with direct observation by health workers (at health centres or by community health workers); DOTS with direct observation by family members; and DOTS without direct observation. The clinical trial found no statistically significant difference in cure rate for the different arms. The economic study collected data on the full range of health service costs and patient costs of the different treatment arms. Data were also disaggregated by gender, rural and urban patients, by treatment site and by economic categories, to investigate the costs of the different strategies, their cost-effectiveness and the impact that they might have on patient compliance with treatment. The study found that direct observation by health centre-based health workers was the least cost-effective of the strategies tested (US dollars 310 per case cured). This is an interesting result, as this is the model recommended by the World Health Organization and International Union against Tuberculosis and Lung Disease. Attending health centres daily during the first 2 months generated high patient costs (direct and in terms of time lost), yet cure rates for this group fell below those of the non-observed group (58%, compared with 62%). One factor suggested by this study is that the high costs of attending may be deterring patients, and in particular, economically active patients who have most to lose from the time taken by direct observation. Without stronger evidence of benefits, it is hard to justify the costs to health services and patients that this type of direct observation imposes. The self-administered group came out as most cost-effective (164 dollars per case cured). The community health worker sub-group achieved the

  14. Formulary Selection Criteria for Biosimilars: Considerations for US Health-System Pharmacists

    PubMed Central

    McBride, Ali; Stevenson, James G.; Green, Larry

    2014-01-01

    Abstract Pharmacists will play a key role in evaluating biosimilars for formulary inclusion in the United States. As defined by US law, a biosimilar is a biologic that is highly similar to its reference product, notwithstanding minor differences in clinically inactive components, and should not have clinically meaningful differences from its reference product in safety, purity, and potency. We review biosimilars and the current European Union and US regulatory pathways for biosimilars. Furthermore, we propose a checklist of considerations to ensure that US pharmacists thoroughly evaluate future biosimilars for formulary inclusion. Included in the checklist are considerations related to the availability of preapproval and postapproval safety and efficacy data; differences in product characteristics and immunogenicity between the biosimilar and reference product; manufacturer-related parameters that can affect a reliable supply of quality products; health-system and patient perspectives on product packaging, labeling, storage, and administration; costs and insurance coverage; patient education; interchangeability and differences in the range of indications; and evaluation of institutions’ information technology systems. PMID:25477613

  15. Tungsten fiber reinforced superalloy composite high temperature component design considerations

    NASA Technical Reports Server (NTRS)

    Winsa, E. A.

    1982-01-01

    Tungsten fiber reinforced superalloy composites (TFRS) are intended for use in high temperature turbine components. Current turbine component design methodology is based on applying the experience, sometimes semiempirical, gained from over 30 years of superalloy component design. Current composite component design capability is generally limited to the methodology for low temperature resin matrix composites. Often the tendency is to treat TFRS as just another superalloy or low temperature composite. However, TFRS behavior is significantly different than that of superalloys, and the high environment adds consideration not common in low temperature composite component design. The methodology used for preliminary design of TFRS components are described. Considerations unique to TFRS are emphasized.

  16. Differences of the Solar Magnetic Activity Signature in Velocity and Intensity Helioseismic Observations

    NASA Astrophysics Data System (ADS)

    Salabert, D.; García, R. A.; Jiménez, A.

    2013-12-01

    The high-quality, full-disk helioseismic observations continuously collected by the spectrophotometer GOLF and the three photometers VIRGO/SPMs onboard the SoHO spacecraft for 17 years now (since April 11, 1996, apart from the SoHO “vacations”) are absolutely unique for the study of the interior of the Sun and its variability with magnetic activity. Here, we look at the differences in the low-degree oscillation p-mode frequencies between radial velocity and intensity measurements taking into account all the known features of the p-mode profiles (e.g., the opposite peak asymmetry), and of the power spectrum (e.g., the presence of the higher degrees ℓ = 4 and 5 in the signal). We show that the intensity frequencies are higher than the velocity frequencies during the solar cycle with a clear temporal dependence. The response between the individual angular degrees is also different. Time delays are observed between the temporal variations in GOLF and VIRGO frequencies. Such analysis is important in order to put new constraints and to better understand the mechanisms responsible for the temporal variations of the oscillation frequencies with the solar magnetic activity as well as their height dependences in the solar atmosphere. It is also important for the study of the stellar magnetic activity using asteroseismic data.

  17. Global long-term ozone trends derived from different observed and modelled data sets

    NASA Astrophysics Data System (ADS)

    Coldewey-Egbers, M.; Loyola, D.; Zimmer, W.; van Roozendael, M.; Lerot, C.; Dameris, M.; Garny, H.; Braesicke, P.; Koukouli, M.; Balis, D.

    2012-04-01

    The long-term behaviour of stratospheric ozone amounts during the past three decades is investigated on a global scale using different observed and modelled data sets. Three European satellite sensors GOME/ERS-2, SCIAMACHY/ENVISAT, and GOME-2/METOP are combined and a merged global monthly mean total ozone product has been prepared using an inter-satellite calibration approach. The data set covers the 16-years period from June 1995 to June 2011 and it exhibits an excellent long-term stability, which is required for such trend studies. A multiple linear least-squares regression algorithm using different explanatory variables is applied to the time series and statistically significant positive trends are detected in the northern mid latitudes and subtropics. Global trends are also estimated using a second satellite-based Merged Ozone Data set (MOD) provided by NASA. For few selected geographical regions ozone trends are additionally calculated using well-maintained measurements of individual Dobson/Brewer ground-based instruments. A reasonable agreement in the spatial patterns of the trends is found amongst the European satellite, the NASA satellite, and the ground-based observations. Furthermore, two long-term simulations obtained with the Chemistry-Climate Models E39C-A provided by German Aerospace Center and UMUKCA-UCAM provided by University of Cambridge are analysed.

  18. Understanding Observational Learning: An Interbehavioral Approach

    PubMed Central

    Fryling, Mitch J; Johnston, Cristin; Hayes, Linda J

    2011-01-01

    Observational learning is an important area in the field of psychology and behavior science more generally. Given this, it is essential that behavior analysts articulate a sound theory of how behavior change occurs through observation. This paper begins with an overview of seminal research in the area of observational learning, followed by a consideration of common behavior analytic conceptualizations of these findings. The interbehavioral perspective is then outlined, shedding light on some difficulties with the existing behavior analytic approaches. The implications of embracing the interbehavioral perspective for understanding the most complex sorts of behavior, including those involved in observational learning are considered. PMID:22532764

  19. Atmospheric CO2 Variability Observed From ASCENDS Flight Campaigns

    NASA Technical Reports Server (NTRS)

    Lin, Bing; Browell, Edward; Campbell, Joel; Choi, Yonghoon; Dobler, Jeremy; Fan, Tai-Fang; Harrison, F. Wallace; Kooi, Susan; Liu, Zhaoyan; Meadows, Byron; hide

    2015-01-01

    Significant atmospheric CO2 variations on various spatiotemporal scales were observed during ASCENDS flight campaigns. For example, around 10-ppm CO2 changes were found within free troposphere in a region of about 200x300 sq km over Iowa during a summer 2014 flight. Even over extended forests, about 2-ppm CO2 column variability was measured within about 500-km distance. For winter times, especially over snow covered ground, relatively less horizontal CO2 variability was observed, likely owing to minimal interactions between the atmosphere and land surface. Inter-annual variations of CO2 drawdown over cornfields in the Mid-West were found to be larger than 5 ppm due to slight differences in the corn growing phase and meteorological conditions even in the same time period of a year. Furthermore, considerable differences in atmospheric CO2 profiles were found during winter and summer campaigns. In the winter CO2 was found to decrease from about 400 ppm in the atmospheric boundary layer (ABL) to about 392 ppm above 10 km, while in the summer CO2 increased from 386 ppm in the ABL to about 396 ppm in free troposphere. These and other CO2 observations are discussed in this presentation.

  20. Environmental risk assessment of pharmaceutical drug substances--conceptual considerations.

    PubMed

    Länge, Reinhard; Dietrich, Daniel

    2002-05-10

    Drugs, i.e. active ingredients of human medicinal products, may be introduced into the environment after use in patients by sewage effluent pathways and consequently are detected at low concentrations in sewage effluents and in surface waters. Legal requirements in a number of geographical regions (Europe, US, and intended in Canada) demand environmental risk assessments (ERA) for new drug substances. Existing regulatory concepts of ERA are based initially on a set of short-term ecotoxicological studies in three to four different species, environmental behavior and the application of assessment factors to correct for the ERA inherent uncertainty. Based on theoretical considerations and the experience with a very limited, but well investigated, number of examples while considering that drugs are highly biologically active compounds, the appropriateness of this risk assessment procedure for all drug substances might be questioned. Indeed, e.g. long-term effects may occur at much lower concentrations and follow different toxicodynamic mechanism than extrapolated from short-term studies., In such cases, the application of assessment factors for deriving chronic no-observed effect concentration (NOECs) appears to be problematic. Although long-term tests with a variety of organisms would provide a complete database for the evaluation of the environmental risks, this is unachievable for all drugs due to time, money and animal welfare constraints. In order to avoid unnecessary testing, a concept is presented, which makes use of pharmacological and toxicological, as well as pharmaco- and toxicokinetic information derived from mammals during drug substance development. Useful data for adoption in a case-by-case testing strategy can be obtained by evaluating (a) the pharmacological activity, which indicates specific targets in mammalian species and may allow for an analysis, whether a similar target is available in aquatic species; (b) the mammalian toxicity, which may

  1. [Interspecies differences of noopept pharmacokinetics].

    PubMed

    Boĭko, S S; Korotkov, S A; Zherdev, V P; Gudasheva, T A; Ostrovskaia, R U; Voronina, T A

    2004-01-01

    Significant interspecific differences in the pharmacokinetics of noopept are manifested by a decrease in the drug elimination rate on the passage from rats to rabbits and humans. Very intensive metabolism of noopept was observed upon intravenous administration in rats. In these animals, presystemic elimination mechanisms lead to the formation of a specific metabolite representing a product of drug biotransformation hydroxylated at the phenyl ring. In rabbits, unchanged noopept circulates in the blood for a longer time upon both intravenous and peroral introduction, biotransformation proceeds at a much slower rate, and no metabolites analogous to that found in rats are detected. The noopept pharmacokinetics in humans differs from that in animals by still slower elimination and considerable individual variability. No drug metabolites are found in the human blood plasma, probably because of a relatively small dose and low concentration.

  2. [Theoretical and practical considerations in rational polytherapy for epilepsy].

    PubMed

    Rajna, Péter

    2011-11-30

    Author analyses the consideration of rational polytherapy for epilepsy. Among the theoretical aspects he points the different effect of seizure inhibitory drugs on the epilepsy models but didn't find data enough for the basis of any successful combination. Combinations of compounds having different way of action are more promising. Rational polytherapy can serve also the epileptic patients' tailored therapy in the daily routine. There have already been some proved synergisms concerning drug interactions. Based on detailed analysis of side effects a possibility occurs for neutralization of side effects when anticonvulsants with side effects of opposite nature are combined. Considering both the side effect profiles and the different (somatic and psychic) habits of the patients we can create a special list of favourable combinations. Co-morbid states and their treatments play a significant role in the application of rational polytherapy. Combination of anticonvulsants of lower potential but without drug-interactions can be the choice in these cases. The non-epileptic indications of the anticonvulsants can also be utilized in polymorbid patients. Based on the theoretical and practical considerations the author defines the ten-step-cognitive-preparation-process in planning the optimal (poly)therapy. On speculative basis he suggests eight beneficial versions of seizure inhibitory rational polytherapy.

  3. Exploring the difference in xerogels and organogels through in situ observation

    PubMed Central

    Li, Zhiming; Wang, Haitao; Li, Min; Ozaki, Yukihiro; Wei, Jue

    2018-01-01

    Solvent–gelator interactions play a key role in mediating organogel formation and ultimately determine the physico-chemical properties of the organogels and xerogels. The ethanol organogels of 1,4-bis[(3,4,5-trihexyloxy phenyl)hydrazide]phenylene (TC6) were investigated in situ by FT-IR, Raman and fluorescence spectra, and XRD, and it was confirmed that the intermolecular interaction and aggregation structure of TC6 ethanol organogels were quite different from those of xerogels. Simultaneously, unprecedented phase transition from organogel to suspension upon heating was observed in ethanol organogel, and the suspension phase exhibited lytropic liquid crystalline behaviour with a rectangular columnar structure. This study may open the possibility to design new gelators with a new dimension of versatility. PMID:29410792

  4. 28 CFR 2.21 - Reparole consideration guidelines.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Reparole consideration guidelines. 2.21....21 Reparole consideration guidelines. (a)(1) If revocation is based upon administrative violation(s... analogy with listed federal offense behaviors. (b) The guidelines for parole consideration specified at 28...

  5. 46 CFR 190.01-15 - Special consideration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Special consideration. 190.01-15 Section 190.01-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS CONSTRUCTION AND ARRANGEMENT Hull Structure § 190.01-15 Special consideration. (a) Special consideration will...

  6. Human perception considerations for 3D content creation

    NASA Astrophysics Data System (ADS)

    Green, G. Almont

    2011-03-01

    Observation and interviews with people viewing autostereoscopic 3D imagery provides evidence that there are many human perception considerations required for 3D content creation. A study was undertaken whereby it was witnessed that certain test autostereoscopic imagery elicited a highly emotional response and engagement, while other test autostereoscopic imagery was given only a passing glance. That an image can be viewed with a certain level of stereopsis does not make it compelling. By taking into consideration the manner in which humans perceive depth and the space between objects, 3D content can achieve a level of familiarity and realness that is not possible with single perspective imagery. When human perception issues are ignored, 3D imagery can be undesirable to viewers and a negative bias against 3D imagery can occur. The preparation of 3D content is more important than the display technology. Where human perception, as it is used to interpret reality, is not mimicked in the creation of 3D content, the general public typically express a negative bias against that imagery (where choices are provided). For some, the viewing of 3D content that could not exist naturally, induces physical discomfort.

  7. Arctic Sea ice thickness loss determined using subsurface, aircraft, and satellite observations

    NASA Astrophysics Data System (ADS)

    Lindsay, R. W.; Schweiger, A. J. B.

    2014-12-01

    Sea ice thickness is a fundamental climate state variable. However, observations of ice thickness have been sparse in time and space making the construction of observation-based time series difficult. Moreover, different groups use a variety of methods and processing procedures to measure ice thickness and each observational source likely has different and poorly characterized measurement and sampling biases. Observational sources include upward looking sonars mounted on submarines or moorings, electromagnetic sensors on helicopters or aircraft, and lidar or radar altimeters on airplanes or satellites. Are these data sources now adequate so that we can construct time series of the mean sea ice thickness with meaningful information about thickness changes? How do the different measurement systems compare in the mean? Are there systematic differences? Very few of the observations provide overlapping measurements of ice of a variety of thickness classes or types for direct comparisons. Error characteristics may vary considerably depending on the presence or thickness of the ridged ice. Here we use a curve-fitting approach to evaluate the systematic differences between eight different observation systems in the Arctic Basin, including ICESat and IceBridge measurements. The approach determines the large-scale spatial and temporal variability of the ice thickness as well as the mean differences between the observation systems using over 3000 estimates of the ice thickness. The thickness estimates are measured over spatial scales of approximately 50 km or time scales of 1 month and the primary time period analyzed is 2000-2013 when the modern mix of observations is available. Good agreement is found between five of the systems, within 0.15 m, while systematic differences of up to 0.5 m are found for three others compare to the five. The annual mean ice thickness for the central Arctic Basin based on observations only has decreased from 3.45 m in 1975 to 1.11 m in 2013, a

  8. Assessment of Evapotranspiration and Soil Moisture Content Across Different Scales of Observation

    PubMed Central

    Verstraeten, Willem W.; Veroustraete, Frank; Feyen, Jan

    2008-01-01

    The proper assessment of evapotranspiration and soil moisture content are fundamental in food security research, land management, pollution detection, nutrient flows, (wild-) fire detection, (desert) locust, carbon balance as well as hydrological modelling; etc. This paper takes an extensive, though not exhaustive sample of international scientific literature to discuss different approaches to estimate land surface and ecosystem related evapotranspiration and soil moisture content. This review presents: (i)a summary of the generally accepted cohesion theory of plant water uptake and transport including a shortlist of meteorological and plant factors influencing plant transpiration;(ii)a summary on evapotranspiration assessment at different scales of observation (sap-flow, porometer, lysimeter, field and catchment water balance, Bowen ratio, scintillometer, eddy correlation, Penman-Monteith and related approaches);(iii)a summary on data assimilation schemes conceived to estimate evapotranspiration using optical and thermal remote sensing; and(iv)for soil moisture content, a summary on soil moisture retrieval techniques at different spatial and temporal scales is presented. Concluding remarks on the best available approaches to assess evapotranspiration and soil moisture content with and emphasis on remote sensing data assimilation, are provided. PMID:27879697

  9. The Influence of Cloud Field Uniformity on Observed Cloud Amount

    NASA Astrophysics Data System (ADS)

    Riley, E.; Kleiss, J.; Kassianov, E.; Long, C. N.; Riihimaki, L.; Berg, L. K.

    2017-12-01

    Two ground-based measurements of cloud amount include cloud fraction (CF) obtained from time series of zenith-pointing radar-lidar observations and fractional sky cover (FSC) acquired from a Total Sky Imager (TSI). In comparison with the radars and lidars, the TSI has a considerably larger field of view (FOV 100° vs. 0.2°) and therefore is expected to have a different sensitivity to inhomogeneity in a cloud field. Radiative transfer calculations based on cloud properties retrieved from narrow-FOV overhead cloud observations may differ from shortwave and longwave flux observations due to spatial variability in local cloud cover. This bias will impede radiative closure for sampling reasons rather than the accuracy of cloud microphysics retrievals or radiative transfer calculations. Furthermore, the comparison between observed and modeled cloud amount from large eddy simulations (LES) models may be affected by cloud field inhomogeneity. The main goal of our study is to estimate the anticipated impact of cloud field inhomogeneity on the level of agreement between CF and FSC. We focus on shallow cumulus clouds observed at the U.S. Department of Energy Atmospheric Radiation Measurement Facility's Southern Great Plains (SGP) site in Oklahoma, USA. Our analysis identifies cloud field inhomogeneity using a novel metric that quantifies the spatial and temporal uniformity of FSC over 100-degree FOV TSI images. We demonstrate that (1) large differences between CF and FSC are partly attributable to increases in inhomogeneity and (2) using the uniformity metric can provide a meaningful assessment of uncertainties in observed cloud amount to aide in comparing ground-based measurements to radiative transfer or LES model outputs at SGP.

  10. Considerations for proper selection of dental cements.

    PubMed

    Simon, James F; Darnell, Laura A

    2012-01-01

    Selecting the proper cement for sufficient bond strength has become progressively complicated as the number of different materials for indirect restorations has increased. The success of any restoration is highly dependent on the proper cement being chosen and used. The function of the cement is not only to seal the restoration on the tooth but also, in some cases, to support the retention of the restoration. This ability to strengthen retention varies by the cement chosen by the clinician; therefore, careful consideration must precede cement selection.

  11. Paediatricians, social media and blogs: Ethical considerations.

    PubMed

    St-Laurent-Gagnon, Thérèse; Coughlin, Kevin W

    2012-05-01

    The use of blogs, Facebook and similar social networking sites is rapidly expanding and, when compared with e-mail, may be having a significantly different impact on the traditional doctor-patient relationship. Characteristics specific to these online platforms have major implications for professional relationships, including the 'Facebook effect' (the relative permanence of postings) and the 'online disinhibition effect'. The present practice point illustrates relevant ethical considerations and provides guidance to paediatricians and others concerning the prudent professional and personal use of social networking media.

  12. A New Strategy in Observer Modeling for Greenhouse Cucumber Seedling Growth

    PubMed Central

    Qiu, Quan; Zheng, Chenfei; Wang, Wenping; Qiao, Xiaojun; Bai, He; Yu, Jingquan; Shi, Kai

    2017-01-01

    State observer is an essential component in computerized control loops for greenhouse-crop systems. However, the current accomplishments of observer modeling for greenhouse-crop systems mainly focus on mass/energy balance, ignoring physiological responses of crops. As a result, state observers for crop physiological responses are rarely developed, and control operations are typically made based on experience rather than actual crop requirements. In addition, existing observer models require a large number of parameters, leading to heavy computational load and poor application feasibility. To address these problems, we present a new state observer modeling strategy that takes both environmental information and crop physiological responses into consideration during the observer modeling process. Using greenhouse cucumber seedlings as an instance, we sample 10 physiological parameters of cucumber seedlings at different time point during the exponential growth stage, and employ them to build growth state observers together with 8 environmental parameters. Support vector machine (SVM) acts as the mathematical tool for observer modeling. Canonical correlation analysis (CCA) is used to select the dominant environmental and physiological parameters in the modeling process. With the dominant parameters, simplified observer models are built and tested. We conduct contrast experiments with different input parameter combinations on simplified and un-simplified observers. Experimental results indicate that physiological information can improve the prediction accuracies of the growth state observers. Furthermore, the simplified observer models can give equivalent or even better performance than the un-simplified ones, which verifies the feasibility of CCA. The current study can enable state observers to reflect crop requirements and make them feasible for applications with simplified shapes, which is significant for developing intelligent greenhouse control systems for modern

  13. A New Strategy in Observer Modeling for Greenhouse Cucumber Seedling Growth.

    PubMed

    Qiu, Quan; Zheng, Chenfei; Wang, Wenping; Qiao, Xiaojun; Bai, He; Yu, Jingquan; Shi, Kai

    2017-01-01

    State observer is an essential component in computerized control loops for greenhouse-crop systems. However, the current accomplishments of observer modeling for greenhouse-crop systems mainly focus on mass/energy balance, ignoring physiological responses of crops. As a result, state observers for crop physiological responses are rarely developed, and control operations are typically made based on experience rather than actual crop requirements. In addition, existing observer models require a large number of parameters, leading to heavy computational load and poor application feasibility. To address these problems, we present a new state observer modeling strategy that takes both environmental information and crop physiological responses into consideration during the observer modeling process. Using greenhouse cucumber seedlings as an instance, we sample 10 physiological parameters of cucumber seedlings at different time point during the exponential growth stage, and employ them to build growth state observers together with 8 environmental parameters. Support vector machine (SVM) acts as the mathematical tool for observer modeling. Canonical correlation analysis (CCA) is used to select the dominant environmental and physiological parameters in the modeling process. With the dominant parameters, simplified observer models are built and tested. We conduct contrast experiments with different input parameter combinations on simplified and un-simplified observers. Experimental results indicate that physiological information can improve the prediction accuracies of the growth state observers. Furthermore, the simplified observer models can give equivalent or even better performance than the un-simplified ones, which verifies the feasibility of CCA. The current study can enable state observers to reflect crop requirements and make them feasible for applications with simplified shapes, which is significant for developing intelligent greenhouse control systems for modern

  14. Consideration of health inequalities in systematic reviews: a mapping review of guidance.

    PubMed

    Maden, Michelle

    2016-11-28

    Given that we know that interventions shown to be effective in improving the health of a population may actually widen the health inequalities gap while others reduce it, it is imperative that all systematic reviewers consider how the findings of their reviews may impact (reduce or increase) on the health inequality gap. This study reviewed existing guidance on incorporating considerations of health inequalities in systematic reviews in order to examine the extent to which they can help reviewers to incorporate such issues. A mapping review was undertaken to identify guidance documents that purported to inform reviewers on whether and how to incorporate considerations of health inequalities. Searches were undertaken in Medline, CINAHL and The Cochrane Library Methodology Register. Review guidance manuals prepared by international organisations engaged in undertaking systematic reviews, and their associated websites were scanned. Studies were included if they provided an overview or discussed the development and testing of guidance for dealing with the incorporation of considerations of health inequalities in evidence synthesis. Results are summarised in narrative and tabular forms. Twenty guidance documents published between 2009 and 2016 were included. Guidance has been produced to inform considerations of health inequalities at different stages of the systematic review process. The Campbell and Cochrane Equity Group have been instrumental in developing and promoting such guidance. Definitions of health inequalities and guidance differed across the included studies. All but one guidance document were transparent in their method of production. Formal methods of evaluation were reported for six guidance documents. Most of the guidance was operationalised in the form of examples taken from published systematic reviews. The number of guidance items to operationalise ranges from 3 up to 26 with a considerable overlap noted. Adhering to the guidance will require more

  15. Insights from modeling and observational evaluation of a precipitating continental cumulus event observed during the MC3E field campaign

    DOE PAGES

    Mechem, David B.; Giangrande, Scott E.; Wittman, Carly S.; ...

    2015-03-13

    A case of shallow cumulus and precipitating cumulus congestus sampled at the Atmospheric Radiation Measurement (ARM) Program Southern Great Plains (SGP) supersite is analyzed using a multi-sensor observational approach and numerical simulation. Observations from a new radar suite surrounding the facility are used to characterize the evolving statistical behavior of the precipitating cloud system. This is accomplished using distributions of different measures of cloud geometry and precipitation properties. Large-eddy simulation (LES) with size-resolved (bin) microphysics is employed to determine the forcings most important in producing the salient aspects of the cloud system captured in the radar observations. Our emphasis ismore » on assessing the importance of time-varying vs. steady-state large-scale forcing on the model's ability to reproduce the evolutionary behavior of the cloud system. Additional consideration is given to how the characteristic spatial scale and homogeneity of the forcing imposed on the simulation influences the evolution of cloud system properties. Results indicate that several new scanning radar estimates such as distributions of cloud top are useful to differentiate the value of time-varying (or at least temporally well-matched) forcing on LES solution fidelity.« less

  16. Opioid Use in the Twenty First Century: Similarities and Differences Across National Borders

    PubMed Central

    Vasilev, Georgi; Milcheva, Svetla; Vassileva, Jasmin

    2016-01-01

    Opinion Statement The global prevalence in the use of opiates and opioids has remained stable, though there were some unprecedented recent increases in opioid use and associated mortality and morbidity in the United States. Internationally, there is a strong tendency for consolidation of drug treatment strategies in favor of more systematic, structured and balanced approaches to regional and national drug policies. However, there are considerable differences in the scope, focus, and implementation of national drug policies and the political context is shaping drug prevention, treatment and rehabilitation efforts to an extent not typically observed in other public health domains. As a result, though in theory, there is a considerable multi-national agreement about the efficacy and effectiveness of different treatment modalities for opioid dependence, in practice, there are striking differences among different world regions and countries in the degree of implementation of these treatment modalities into clinical practice. Such discrepancies between theory and practice are observed even in high-income countries such as the United States and European Union member states, where evidence-based treatment modalities are still not well implemented into clinical practice. Despite the lack of evidence-based support for the role of detoxification as a stand-alone treatment for opioid use disorders, it appears to be the most widely used intervention for opioid use across the world. PMID:27493878

  17. Alternative Fuels Data Center: Hydrogen Benefits and Considerations

    Science.gov Websites

    Benefits and Considerations to someone by E-mail Share Alternative Fuels Data Center: Hydrogen Benefits and Considerations on Facebook Tweet about Alternative Fuels Data Center: Hydrogen Benefits and Considerations on Twitter Bookmark Alternative Fuels Data Center: Hydrogen Benefits and Considerations on Google

  18. Various fates of neuronal progenitor cells observed on several different chemical functional groups

    NASA Astrophysics Data System (ADS)

    Liu, Xi; Wang, Ying; He, Jin; Wang, Xiu-Mei; Cui, Fu-Zhai; Xu, Quan-Yuan

    2011-12-01

    Neuronal progenitor cells cultured on gold-coated glass surfaces modified by different chemical functional groups, including hydroxyl (-OH), carboxyl (-COOH), amino (-NH2), bromo (-Br), mercapto (-SH), - Phenyl and methyl (-CH3), were studied here to investigate the influence of surface chemistry on the cells' adhesion, morphology, proliferation and functional gene expression. Focal adhesion staining indicated in the initial culture stage cells exhibited morphological changes in response to different chemical functional groups. Cells cultured on -NH2 grafted surface displayed focal adhesion plaque and flattened morphology and had the largest contact area. However, their counter parts on -CH3 grafted surface displayed no focal adhesion and rounded morphology and had the smallest contact area. After 6 days culture, the proliferation trend was as follows: -NH2 > -SH> -COOH> - Phenyl > - Br > -OH> -CH3. To determine the neural functional properties of the cells affected by surface chemistry, the expression of glutamate decarboxylase (GAD67), nerve growth factor (NGF) and brainderived neurotrophic factor (BDNF) were characterized. An increase of GAD67 expression was observed on -NH2, -COOH and -SH grafted surfaces, while no increase in NGF and BDNF expression was observed on any chemical surfaces. These results highlight the importance of surface chemistry in the fate determination of neuronal progenitor cells, and suggest that surface chemistry must be considered in the design of biomaterials for neural tissue engineering.

  19. Environmental considerations in Swedish Forestry: A study of the administrative process

    NASA Astrophysics Data System (ADS)

    Eckerberg, Katarina

    1985-01-01

    This report briefly describes the implementation process involving nature conservation considerations in forestry, according to a recently passed law in Sweden. Described are the forestry and political systems in Sweden regarding nature conservation in forestry, as well as of the administrative process involved when a forest is going to be clearcut. Conclusions are based upon the conditions and outcome of two clearcutting cases outlined in this report, and are focused on the interactions and control functions among various agencies and levels of government. The policy on the consideration of nature in forestry is, to a large extent, formed at a very low level in the bureaucracy and is subject to negotiation from case to case. Checkups between different agencies as a form of concurrent government become important means of implementing environmental considerations in forestry, having the split roles and interests of the authorities in mind.

  20. The relationship between the MAOA-uVNTR polymorphism, delinquent peer affiliation, and antisocial behavior with a consideration of sex differences.

    PubMed

    Cooke, Eric M; Armstrong, Todd; Boisvert, Danielle; Wells, Jessica; Lewis, Richard H; Hughes-Stamm, Sheree; Gangitano, David

    2018-05-05

    With the advent of new and more readily usable gene sequencing techniques, researchers have been able to examine the interactions between genes and the environment (G X E) within a multitude of scientific perspectives. One area that G X E interactions have been implicated in is the development of antisocial behavior (ASB). Antisocial behavior consists of a wide range of maladaptive behaviors and has been at the forefront of public health and mental health concerns for decades. One genetic polymorphism that has been associated with ASB is MAOA-uVNTR. Meta-analytic studies have found the low-activity MAOA-uVNTR polymorphism to be associated with ASB from early childhood through adulthood. Recently, studies have begun to examine the independent and interactive G X E relationship between MAOA-uVNTR and deviant peer affiliation on ASB. Inconsistent with the broader literature, these findings suggest an interaction between high-activity MAOA-uVNTR and deviant peer affiliation on ASB in a mixed sex sample. The current study re-examines the relationship between MAOA-uVNTR, peer delinquency, and ASB with a consideration of sex differences in 291 college participants. Findings indicate an interaction between the low-activity allele of the MAOA-uVNTR and peer delinquency in predicting ASB. Results are also specific to differences between the sexes. Implications and future research are discussed.

  1. Topographic assessment of human enamel surface treated with different topical sodium fluoride agents: Scanning electron microscope consideration.

    PubMed

    Brar, Gurlal Singh; Arora, Amandeep Singh; Khinda, Vineet Inder Singh; Kallar, Shiminder; Arora, Karuna

    2017-01-01

    Continuous balanced demineralization and remineralization are natural dynamic processes in enamel. If the balance is interrupted and demineralization process dominates, it may eventually lead to the development of carious lesions in enamel and dentine. Fluoride helps control decay by enhancing remineralization and altering the structure of the tooth, making the surface less soluble. One hundred and twenty sound human permanent incisors randomly and equally distributed into six groups as follows: Group I - Control, II - Sodium fluoride solution, III - Sodium fluoride gel, IV - Sodium fluoride varnish, V - Clinpro Tooth Crème (3M ESPE), and VI-GC Tooth Mousse Plus or MI Paste Plus. The samples were kept in artificial saliva for 12 months, and the topical fluoride agents were applied to the respective sample groups as per the manufacturer instructions. Scanning electron microscope (SEM) evaluation of all the samples after 6 and 12 months was made. Morphological changes on the enamel surface after application of fluoride in SEM revealed the presence of globular precipitate in all treated samples. Amorphous, globular, and crystalline structures were seen on the enamel surface of the treated samples. Clear differences were observed between the treated and untreated samples. Globular structures consisting of amorphous CaF2precipitates, which acted as a fluoride reservoir, were observed on the enamel surface after action of different sodium fluoride agents. CPP-ACPF (Tooth Mousse) and Tricalcium phosphate with fluoride (Clinpro tooth crème) are excellent delivery vehicles available in a slow release amorphous form to localize fluoride at the tooth surface.

  2. Conceptual and statistical issues in couples observational research: Rationale and methods for design decisions.

    PubMed

    Baucom, Brian R W; Leo, Karena; Adamo, Colin; Georgiou, Panayiotis; Baucom, Katherine J W

    2017-12-01

    Observational behavioral coding methods are widely used for the study of relational phenomena. There are numerous guidelines for the development and implementation of these methods that include principles for creating new and adapting existing coding systems as well as principles for creating coding teams. While these principles have been successfully implemented in research on relational phenomena, the ever expanding array of phenomena being investigated with observational methods calls for a similar expansion of these principles. Specifically, guidelines are needed for decisions that arise in current areas of emphasis in couple research including observational investigation of related outcomes (e.g., relationship distress and psychological symptoms), the study of change in behavior over time, and the study of group similarities and differences in the enactment and perception of behavior. This article describes conceptual and statistical considerations involved in these 3 areas of research and presents principle- and empirically based rationale for design decisions related to these issues. A unifying principle underlying these guidelines is the need for careful consideration of fit between theory, research questions, selection of coding systems, and creation of coding teams. Implications of (mis)fit for the advancement of theory are discussed. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  3. Using GEO Optical Observations to Infer Orbit Populations

    NASA Technical Reports Server (NTRS)

    Matney, Mark; Africano, John

    2002-01-01

    NASA's Orbital Debris measurements program has a goal to characterize the small debris environment in the geosynchronous Earth-orbit (GEO) region using optical telescopes ("small" refers to objects too small to catalog and track with current systems). Traditionally, observations of GEO and near-GEO objects involve following the object with the telescope long enough to obtain an orbit. When observing very dim objects with small field-of-view telescopes, though, the observations are generally too short to obtain accurate orbital elements. However, it is possible to use such observations to statistically characterize the small object environment. A telescope pointed at a particular spot could potentially see objects in a number of different orbits. Inevitably, when looking at one region for certain types of orbits, there are objects in other types of orbits that cannot be seen. Observation campaigns are designed with these limitations in mind and are set up to span a number of regions of the sky, making it possible to sample all potential orbits under consideration. Each orbit is not seen with the same probability, however, so there are observation biases intrinsic to any observation campaign. Fortunately, it is possible to remove such biases and reconstruct a meaningful estimate of the statistical orbit populations of small objects in GEO. This information, in turn, can be used to investigate the nature of debris sources and to characterize the risk to GEO spacecraft. This paper describes these statistical tools and presents estimates of small object GEO populations.

  4. Comparison between self-reported and observed food handling behaviors among Latinas.

    PubMed

    Dharod, Jigna Morarji; Pérez-Escamilla, Rafael; Paciello, Stefania; Bermúdez-Millán, Angela; Venkitanarayanan, Kumar; Damio, Grace

    2007-08-01

    The study was conducted to compare and identify the magnitude of differences between self-reported and observed food safety behaviors among women preparing a chicken and salad dish at home. The observed food safety practices also were compared according to sociodemographic variables and prior food safety education. Sixty Puerto Rican women who were the main meal preparers for their households were recruited in Hartford, Conn. Three household visits were made to (i) deliver food ingredients to prepare the chicken and salad meal, (ii) conduct household observation, and (iii) conduct a self-reported survey. The difference between self-reported and observed behaviors varied across food handling and sanitation behaviors. There was a high level of inaccuracy for socially desirable behaviors such as hand washing; the vast majority of participants reported practicing these behaviors but they were not observed doing so. Cutting board washing also was considerably overreported, questioning the validity of these self-reported data for regression analyses. There was a significant association (P < 0.05) between proper thawing method and prior food safety education, use of cutting board and higher income, and washing tomatoes and having a positive attitude towards food safety. Results revealed that overreporting errors must be considered when analyzing and/or interpreting data derived from self-reported food safety consumer surveys and that food safety education and positive food safety attitudes are associated with recommended food safety behaviors.

  5. Understanding Arctic Surface Temperature Differences in Reanalyses

    NASA Technical Reports Server (NTRS)

    Cullather, Richard; Zhao, Bin; Shuman, Christopher; Nowicki, Sophie

    2017-01-01

    Reanalyses in the Arctic are widely used for model evaluation and for understanding contemporary climate change. Nevertheless, differences among reanalyses in fundamental meteorological variables including surface air temperature are large. A review of surface temperature differences is presented with a particular focus on differences in contemporary reanalyses. An important consideration is the significant differences in Arctic surfaces, including the central Arctic Ocean, the Greenland Ice Sheet, and non-glaciated land. While there is significant correlation among reanalyses in annual time series, there is substantial disagreement in mean values. For the period 1980-2013, the trend in annual temperature ranges from 0.3 to 0.7K per decade. Over the central Arctic Ocean, differences in mean values and trends are larger. Most of the uncertainty is associated with winter months. This is likely associated with the constraint imposed by melting processes (i.e. 0 deg. Celsius), rather than seasonal changes to the observing system.

  6. Adoption consideration and concerns among young adult female cancer survivors.

    PubMed

    Gorman, Jessica R; Whitcomb, Brian W; Standridge, Daniel; Malcarne, Vanessa L; Romero, Sally A D; Roberts, Samantha A; Su, H Irene

    2017-02-01

    We compared adoption consideration between female young adult cancer survivors and women of the same age in the general US population, hypothesizing that cancer survivors who desired children would report greater interest in adoption than an age-adjusted general population sample who desired children. After age-standardizing the cancer survivor cohort to match the age distribution of the 2006-2010 National Survey for Family Growth (NSFG), we estimated adoption consideration among women age 18-35 years who wanted a (another) child in the two cohorts overall and within age groups. We assessed characteristics and concerns related to adoption consideration among cancer survivors. Among cancer survivors, 81.6 % (95 % CI 75.7-87.6) reported that they would consider adoption compared to 40.3 % (95 % CI 40.3-40.3) of women in the general population. While over 80 % of the cancer survivor sample reported that they would consider adoption, only 15 % of cancer survivors reported no concerns about adoption. The most common concerns were desire for a biological child (48 %), expense (45 %), adoption agency candidacy (41 %), and needing more information (39 %). We observed a twofold higher interest in adoption when comparing the cancer survivor with the general population, suggesting that adoption is a consideration for many young women who have survived cancer. Adoption is an important family-building option for those who want to have a child but are unable to or choose not to have a biological child. However, young adult survivors may need more support to understand and navigate this process.

  7. Finding consistency between different views of the absorption enhancement of black carbon: An observationally constrained hybrid model to support a transition in optical properties with mass fraction

    NASA Astrophysics Data System (ADS)

    Coe, H.; Allan, J. D.; Whitehead, J.; Alfarra, M. R. R.; Villegas, E.; Kong, S.; Williams, P. I.; Ting, Y. C.; Haslett, S.; Taylor, J.; Morgan, W.; McFiggans, G.; Spracklen, D. V.; Reddington, C.

    2015-12-01

    The mixing state of black carbon is uncertain yet has a significant influence on the efficiency with which a particle absorbs light. In turn, this may make a significant contribution to the uncertainty in global model predictions of the black carbon radiative budget. Previous modelling studies that have represented this mixing state using a core-shell approach have shown that aged black carbon particles may be considerably enhanced compared to freshly emitted black carbon due to the addition of co-emitted, weakly absorbing species. However, recent field results have demonstrated that any enhancement of absorption is minor in the ambient atmosphere. Resolving these differences in absorption efficiency is important as they will have a major impact on the extent to which black carbon heats the atmospheric column. We have made morphology-independent measurements of refractory black carbon mass and associated weakly absorbing material in single particles from laboratory-generated diesel soot and black carbon particles in ambient air influenced by traffic and wood burning sources and related these to the optical properties of the particles. We compared our calculated optical properties with optical models that use varying mixing state assumptions and by characterising the behaviour in terms of the relative amounts of weakly absorbing material and black carbon in a particle we show a sharp transition in mixing occurs. We show that the majority of black carbon particles from traffic-dominated sources can be treated as externally mixed and show no absorption enhancement, whereas models assuming internal mixing tend to give the best estimate of the absorption enhancement of thickly coated black carbon particles from biofuel or biomass burning. This approach reconciles the differences in absorption enhancement previously observed and offers a systematic way of treating the differences in behaviour observed.

  8. Do Patterns of Bacterial Diversity along Salinity Gradients Differ from Those Observed for Macroorganisms?

    PubMed Central

    Zhang, Yong; Shen, Ji; van der Gast, Christopher; Hahn, Martin W.; Wu, Qinglong

    2011-01-01

    It is widely accepted that biodiversity is lower in more extreme environments. In this study, we sought to determine whether this trend, well documented for macroorganisms, also holds at the microbial level for bacteria. We used denaturing gradient gel electrophoresis (DGGE) with phylum-specific primers to quantify the taxon richness (i.e., the DGGE band numbers) of the bacterioplankton communities of 32 pristine Tibetan lakes that represent a broad salinity range (freshwater to hypersaline). For the lakes investigated, salinity was found to be the environmental variable with the strongest influence on the bacterial community composition. We found that the bacterial taxon richness in freshwater habitats increased with increasing salinity up to a value of 1‰. In saline systems (systems with >1‰ salinity), the expected decrease of taxon richness along a gradient of further increasing salinity was not observed. These patterns were consistently observed for two sets of samples taken in two different years. A comparison of 16S rRNA gene clone libraries revealed that the bacterial community of the lake with the highest salinity was characterized by a higher recent accelerated diversification than the community of a freshwater lake, whereas the phylogenetic diversity in the hypersaline lake was lower than that in the freshwater lake. These results suggest that different evolutionary forces may act on bacterial populations in freshwater and hypersaline lakes on the Tibetan Plateau, potentially resulting in different community structures and diversity patterns. PMID:22125616

  9. Analysis of multidimensional difference-of-Gaussians filters in terms of directly observable parameters.

    PubMed

    Cope, Davis; Blakeslee, Barbara; McCourt, Mark E

    2013-05-01

    The difference-of-Gaussians (DOG) filter is a widely used model for the receptive field of neurons in the retina and lateral geniculate nucleus (LGN) and is a potential model in general for responses modulated by an excitatory center with an inhibitory surrounding region. A DOG filter is defined by three standard parameters: the center and surround sigmas (which define the variance of the radially symmetric Gaussians) and the balance (which defines the linear combination of the two Gaussians). These parameters are not directly observable and are typically determined by nonlinear parameter estimation methods applied to the frequency response function. DOG filters show both low-pass (optimal response at zero frequency) and bandpass (optimal response at a nonzero frequency) behavior. This paper reformulates the DOG filter in terms of a directly observable parameter, the zero-crossing radius, and two new (but not directly observable) parameters. In the two-dimensional parameter space, the exact region corresponding to bandpass behavior is determined. A detailed description of the frequency response characteristics of the DOG filter is obtained. It is also found that the directly observable optimal frequency and optimal gain (the ratio of the response at optimal frequency to the response at zero frequency) provide an alternate coordinate system for the bandpass region. Altogether, the DOG filter and its three standard implicit parameters can be determined by three directly observable values. The two-dimensional bandpass region is a potential tool for the analysis of populations of DOG filters (for example, populations of neurons in the retina or LGN), because the clustering of points in this parameter space may indicate an underlying organizational principle. This paper concentrates on circular Gaussians, but the results generalize to multidimensional radially symmetric Gaussians and are given as an appendix.

  10. VLBI2010: Networks and Observing Strategies

    NASA Technical Reports Server (NTRS)

    Petrachenko, Bill; Corey, Brian; Himwich, Ed; Ma, Chopo; Malkin, Zinovy; Niell, Arthur; Shaffer, David; Vandenberg, Nancy

    2004-01-01

    The Observing Strategies Sub-group of IVS's Working Group 3 has been tasked with producing a vision for the following aspects of geodetic VLBI: antenna-network structure and observing strategies; source strength/structure/distribution; frequency bands, RFI; and field system and scheduling. These are high level considerations that have far reaching impact since they significantly influence performance potential and also constrain requirements for a number of other \\VG3 sub-groups. The paper will present the status of the sub-group's work on these topics.

  11. Weighing the Social and Ethical Considerations of Maternal-Fetal Surgery.

    PubMed

    Antiel, Ryan M; Flake, Alan W; Collura, Christopher A; Johnson, Mark P; Rintoul, Natalie E; Lantos, John D; Curlin, Farr A; Tilburt, Jon C; Brown, Stephen D; Feudtner, Chris

    2017-12-01

    The ethics of maternal-fetal surgery involves weighing the importance of potential benefits, risks, and other consequences involving the pregnant woman, fetus, and other family members. We assessed clinicians' ratings of the importance of 9 considerations relevant to maternal-fetal surgery. This study was a discrete choice experiment contained within a 2015 national mail-based survey of 1200 neonatologists, pediatric surgeons, and maternal-fetal medicine physicians, with latent class analysis subsequently used to identify groups of physicians with similar ratings. Of 1176 eligible participants, 660 (56%) completed the discrete choice experiment. The highest-ranked consideration was of neonatal benefits, which was followed by consideration of the risk of maternal complications. By using latent class analysis, we identified 4 attitudinal groups with similar patterns of prioritization: "fetocentric" ( n = 232), risk-sensitive ( n = 197), maternal autonomy ( n = 167), and family impact and social support ( n = 64). Neonatologists were more likely to be in the fetocentric group, whereas surgeons were more likely to be in the risk-sensitive group, and maternal-fetal medicine physicians made up the largest percentage of the family impact and social support group. Physicians vary in how they weigh the importance of social and ethical considerations regarding maternal-fetal surgery. Understanding these differences may help prevent or mitigate disagreements or tensions that may arise in the management of these patients. Copyright © 2017 by the American Academy of Pediatrics.

  12. 32 CFR 637.12 - Legal considerations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Legal considerations. 637.12 Section 637.12... CRIMINAL INVESTIGATIONS MILITARY POLICE INVESTIGATION Investigations § 637.12 Legal considerations. (a... of establishing a legal opinion as to whether sufficient credible evidence has been established to...

  13. 32 CFR 637.12 - Legal considerations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Legal considerations. 637.12 Section 637.12... CRIMINAL INVESTIGATIONS MILITARY POLICE INVESTIGATION Investigations § 637.12 Legal considerations. (a... of establishing a legal opinion as to whether sufficient credible evidence has been established to...

  14. 32 CFR 637.12 - Legal considerations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 4 2014-07-01 2013-07-01 true Legal considerations. 637.12 Section 637.12... CRIMINAL INVESTIGATIONS MILITARY POLICE INVESTIGATION Investigations § 637.12 Legal considerations. (a... of establishing a legal opinion as to whether sufficient credible evidence has been established to...

  15. 32 CFR 637.12 - Legal considerations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 4 2013-07-01 2013-07-01 false Legal considerations. 637.12 Section 637.12... CRIMINAL INVESTIGATIONS MILITARY POLICE INVESTIGATION Investigations § 637.12 Legal considerations. (a... of establishing a legal opinion as to whether sufficient credible evidence has been established to...

  16. 32 CFR 637.12 - Legal considerations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 4 2012-07-01 2011-07-01 true Legal considerations. 637.12 Section 637.12... CRIMINAL INVESTIGATIONS MILITARY POLICE INVESTIGATION Investigations § 637.12 Legal considerations. (a... of establishing a legal opinion as to whether sufficient credible evidence has been established to...

  17. 5 CFR 330.206 - Job consideration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Job consideration. 330.206 Section 330.206 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS RECRUITMENT, SELECTION, AND PLACEMENT (GENERAL) Reemployment Priority List (RPL) § 330.206 Job consideration. (a)(1) An...

  18. 5 CFR 330.206 - Job consideration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Job consideration. 330.206 Section 330.206 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS RECRUITMENT, SELECTION, AND PLACEMENT (GENERAL) Reemployment Priority List (RPL) § 330.206 Job consideration. (a)(1) An...

  19. Using observational methods in nursing research.

    PubMed

    Salmon, Jenny

    2015-07-08

    Observation is a research data-collection method used generally to capture the activities of participants as well as when and where things are happening in a given setting. It checks description of the phenomena against what the researcher perceives to be fact in a rich experiential context. The method's main strength is that it provides direct access to the social phenomena under consideration. It can be used quantitatively or qualitatively, depending on the research question. Challenges in using observation relate to adopting the role of participant or non-participant researcher as observer. This article discusses some of the complexities involved when nurse researchers seek to collect observational data on social processes in naturalistic settings using unstructured or structured observational methods in qualitative research methodology. A glossary of research terms is provided.

  20. Observation learning versus physical practice leads to different consolidation outcomes in a movement timing task.

    PubMed

    Trempe, Maxime; Sabourin, Maxime; Rohbanfard, Hassan; Proteau, Luc

    2011-03-01

    Motor learning is a process that extends beyond training sessions. Specifically, physical practice triggers a series of physiological changes in the CNS that are regrouped under the term "consolidation" (Stickgold and Walker 2007). These changes can result in between-session improvement or performance stabilization (Walker 2005). In a series of three experiments, we tested whether consolidation also occurs following observation. In Experiment 1, participants observed an expert model perform a sequence of arm movements. Although we found evidence of observation learning, no significant difference was revealed between participants asked to reproduce the observed sequence either 5 min or 24 h later (no between-session improvement). In Experiment 2, two groups of participants observed an expert model perform two distinct movement sequences (A and B) either 10 min or 8 h apart; participants then physically performed both sequences after a 24-h break. Participants in the 8-h group performed Sequence B less accurately compared to participants in the 5-min group, suggesting that the memory representation of the first sequence had been stabilized and that it interfered with the learning of the second sequence. Finally, in Experiment 3, the initial observation phase was replaced by a physical practice phase. In contrast with the results of Experiment 2, participants in the 8-h group performed Sequence B significantly more accurately compared to participants in the 5-min group. Together, our results suggest that the memory representation of a skill learned through observation undergoes consolidation. However, consolidation of an observed motor skill leads to distinct behavioural outcomes in comparison with physical practice.

  1. Practical Considerations in Pediatric Surgery

    PubMed Central

    Louis, Matthew R.; Meaike, Jesse D.; Chamata, Edward; Hollier, Larry H.

    2016-01-01

    The care of pediatric patients requires special considerations that are often not addressed in the literature. Relatively straightforward tasks such as clinical evaluation, antibiotic use, splinting, wound closure, and care of simple burns become complicated in the pediatric population for several reasons. The authors seek to demystify some of these topics using the senior author's years of clinical experience treating pediatric patients by giving practical advice and general considerations when treating children. PMID:27895539

  2. 7 CFR 25.622 - Other considerations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Other considerations. 25.622 Section 25.622 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.622 Other considerations. (a) Civil rights compliance requirements. All...

  3. 7 CFR 25.622 - Other considerations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Other considerations. 25.622 Section 25.622 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.622 Other considerations. (a) Civil rights compliance requirements. All...

  4. 7 CFR 25.622 - Other considerations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Other considerations. 25.622 Section 25.622 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.622 Other considerations. (a) Civil rights compliance requirements. All...

  5. 7 CFR 25.622 - Other considerations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Other considerations. 25.622 Section 25.622 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.622 Other considerations. (a) Civil rights compliance requirements. All...

  6. 7 CFR 1735.92 - Accounting considerations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Accounting considerations. 1735.92 Section 1735.92... All Acquisitions and Mergers § 1735.92 Accounting considerations. (a) Proper accounting shall be... in the absence of such a commission, as required by RUS based on Generally Accepted Accounting...

  7. 7 CFR 25.622 - Other considerations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Other considerations. 25.622 Section 25.622 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.622 Other considerations. (a) Civil rights compliance requirements. All...

  8. Analysis of sensorless control of brushless DC motor using unknown input observer with different gains

    NASA Astrophysics Data System (ADS)

    Astik, Mitesh B.; Bhatt, Praghnesh; Bhalja, Bhavesh R.

    2017-03-01

    A sensorless control scheme based on an unknown input observer is presented in this paper in which back EMF of the Brushless DC Motor (BLDC) is continuously estimated from available line voltages and currents. During negative rotation of motor, actual and estimated speed fail to track the reference speed and if the corrective action is not taken by the observer, the motor goes into saturation. To overcome this problem, the speed estimation algorithm has been implemented in this paper to control the dynamic behavior of the motor during negative rotation. The Ackermans method was used to calculate the gains of an unknown input observer which is based on the appropriate choice of the eigenvalues in advance. The criteria to choose eigenvalue is to obtain a balance between faster convergence rate and the least noise level. Simulations have been carried out for different disturbances such as step changes in motor reference speed and load torque. The comparative simulation results clearly depict that the disturbance effects in actual and estimated responses minimizes as observer gain setting increases.

  9. A study on bulk and skin temperature difference using observations from Atlantic and Pacific Coastal regions of United States

    NASA Astrophysics Data System (ADS)

    Alappattu, Denny P.; Wang, Qing; Yamaguchi, Ryan; Lind, Richard; Reynolds, Mike; Christman, Adam

    2017-05-01

    Analysis of bulk-skin sea surface temperature (SST) difference form the west and east coasts of United States is presented using the data collected from three field experiments. These experiments were conducted at offshore Duck, North Carolina and in the Monterey Bay of the California coastal region. Bulk SST measurements were made using conventional thermistors from a depth of one meter below the sea level. Infrared radiometers were used to measure the surface skin SST. Depending on measurement depth and prevailing conditions, the bulk SST can differ from skin SST by few tenths of a degree to O(1°C). Difference between bulk and skin SST arise from cools skin and warm layer effects. Bulk-skin SST difference (ΔSST) estimated from east coast observations varied from -0.46°C to 1.24°C. Here, the bulk SST was higher than skin SST most of the time during the observations. This indicates cool skin effect was the dominant factor determining the ΔSST in the east coast. For wind speeds less than 4 m s-1, we also noticed an increase in ΔSST. Additionally, for low winds (<4 m s-1) ΔSST also varied diurnally with the occurrence of generally higher ΔSST in the nighttime in comparison with daytime. Moreover, increase in downwelling longwave radiation reduced the bulk-skin SST difference. ΔSST calculated from the observation in the Monterey bay varied between 2.3° and -2.3°C. This was higher than the variability ΔSST observed at the east coast. Moreover, ΔSST variability observed at west coast was independent of wind speed.

  10. Analyzing the Impact of Different Pcv Calibration Models on Height Determination Using Gps/Glonass Observations from Asg-Eupos Network

    NASA Astrophysics Data System (ADS)

    Dawidowicz, Karol

    2014-12-01

    The integration of GPS with GLONASS is very important in satellite-based positioning because it can clearly improve reliability and availability. However, unlike GPS, GLONASS satellites transmit signals at different frequencies. This results in significant difficulties in modeling and ambiguity resolution for integrated GNSS positioning. There are also some difficulties related to the antenna Phase Center Variations (PCV) problem because, as is well known, the PCV is dependent on the received signal frequency dependent. Thus, processing simultaneous observations from different positioning systems, e.g. GPS and GLONASS, we can expect complications resulting from the different structure of signals and differences in satellite constellations. The ASG-EUPOS multifunctional system for precise satellite positioning is a part of the EUPOS project involving countries of Central and Eastern Europe. The number of its users is increasing rapidly. Currently 31 of 101 reference stations are equipped with GPS/GLONASS receivers and the number is still increasing. The aim of this paper is to study the height solution differences caused by using different PCV calibration models in integrated GPS/GLONASS observation processing. Studies were conducted based on the datasets from the ASG-EUPOS network. Since the study was intended to evaluate the impact on height determination from the users' point of view, a so-called "commercial" software was chosen for post-processing. The analysis was done in a baseline mode: 3 days of GNSS data collected with three different receivers and antennas were used. For the purposes of research the daily observations were divided into different sessions with a session length of one hour. The results show that switching between relative and absolute PCV models may cause an obvious effect on height determination. This issue is particularly important when mixed GPS/GLONASS observations are post-processed.

  11. Topical Review: Families Coping With Child Trauma: A Naturalistic Observation Methodology

    PubMed Central

    Barrett, Anna; Bowles, Peter; Conroy, Rowena; Mehl, Matthias R.

    2016-01-01

    Objective To introduce a novel, naturalistic observational methodology (the Electronically Activated Recorder; EAR) as an opportunity to better understand the central role of the family environment in children’s recovery from trauma. Methods Discussion of current research methods and a systematic literature review of EAR studies on health and well-being. Results Surveys, experience sampling, and the EAR method each provide different opportunities and challenges for studying family interactions. We identified 17 articles describing relevant EAR studies. These investigated questions of emotional well-being, communicative behaviors, and interpersonal relationships, predominantly in adults. 5 articles reported innovative research in children, triangulating EAR-observed behavioral data (e.g., on child conflict at home) with neuroendocrine assay, sociodemographic information, and parent report. Finally, we discussed psychometric, practical, and ethical considerations for conducting EAR research with children and families. Conclusions Naturalistic observation methods such as the EAR have potential for pediatric psychology studies regarding trauma and the family environment. PMID:25797943

  12. Application of remote sensors in coastal zone observations

    NASA Technical Reports Server (NTRS)

    Caillat, J. M.; Elachi, C.; Brown, W. E., Jr.

    1975-01-01

    A review of processes taking place along coastlines and their biological consideration led to the determination of the elements which are required in the study of coastal structures and which are needed for better utilization of the resources from the oceans. The processes considered include waves, currents, and their influence on the erosion of coastal structures. Biological considerations include coastal fisheries, estuaries, and tidal marshes. Various remote sensors were analyzed for the information which they can provide and sites were proposed where a general ocean-observation plan could be tested.

  13. Assessment of Evapotranspiration and Soil Moisture Content Across Different Scales of Observation.

    PubMed

    Verstraeten, Willem W; Veroustraete, Frank; Feyen, Jan

    2008-01-09

    The proper assessment of evapotranspiration and soil moisture content arefundamental in food security research, land management, pollution detection, nutrient flows,(wild-) fire detection, (desert) locust, carbon balance as well as hydrological modelling; etc.This paper takes an extensive, though not exhaustive sample of international scientificliterature to discuss different approaches to estimate land surface and ecosystem relatedevapotranspiration and soil moisture content. This review presents:(i) a summary of the generally accepted cohesion theory of plant water uptake andtransport including a shortlist of meteorological and plant factors influencing planttranspiration;(ii) a summary on evapotranspiration assessment at different scales of observation (sapflow,porometer, lysimeter, field and catchment water balance, Bowen ratio,scintillometer, eddy correlation, Penman-Monteith and related approaches);(iii) a summary on data assimilation schemes conceived to estimate evapotranspirationusing optical and thermal remote sensing; and(iv) for soil moisture content, a summary on soil moisture retrieval techniques atdifferent spatial and temporal scales is presented.Concluding remarks on the best available approaches to assess evapotranspiration and soilmoisture content with and emphasis on remote sensing data assimilation, are provided.

  14. A comparison between the observed and predicted Fe II spectrum in different plasmas

    NASA Astrophysics Data System (ADS)

    Johansson, S.

    This paper gives a survey of the spectral distribution of emission lines of Fe II, predicted from a single atomic model. The observed differences between the recorded and the predicted spectrum are discussed in terms of deficiencies of the model and interactions within the emitting plasma. A number of illustrative examples of unexpected features with applications to astrophysics are given. Selective population, due to charge transfer and resonant photo excitation, is elucidated. The future need of more laboratory data for Fe II as regards energy levels and line classification is also discussed.

  15. 7 CFR 1710.117 - Environmental considerations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Environmental considerations. 1710.117 Section 1710... GUARANTEES Loan Purposes and Basic Policies § 1710.117 Environmental considerations. Borrowers are required... Environmental Policy Act (NEPA), as amended (42 U.S.C. 4321 et seq.); the Council on Environmental Quality...

  16. 7 CFR 1710.117 - Environmental considerations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 11 2011-01-01 2011-01-01 false Environmental considerations. 1710.117 Section 1710... GUARANTEES Loan Purposes and Basic Policies § 1710.117 Environmental considerations. Borrowers are required... Environmental Policy Act (NEPA), as amended (42 U.S.C. 4321 et seq.); the Council on Environmental Quality...

  17. 33 CFR 239.5 - Engineering considerations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Engineering considerations. 239.5 Section 239.5 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF... § 239.5 Engineering considerations. Reports on proposals to provide covered channels shall include a...

  18. 33 CFR 239.5 - Engineering considerations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Engineering considerations. 239.5 Section 239.5 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF... § 239.5 Engineering considerations. Reports on proposals to provide covered channels shall include a...

  19. 33 CFR 239.5 - Engineering considerations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Engineering considerations. 239.5 Section 239.5 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF... § 239.5 Engineering considerations. Reports on proposals to provide covered channels shall include a...

  20. 33 CFR 239.5 - Engineering considerations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Engineering considerations. 239.5 Section 239.5 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF... § 239.5 Engineering considerations. Reports on proposals to provide covered channels shall include a...

  1. 33 CFR 239.5 - Engineering considerations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Engineering considerations. 239.5 Section 239.5 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF... § 239.5 Engineering considerations. Reports on proposals to provide covered channels shall include a...

  2. 46 CFR 169.112 - Special consideration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Special consideration. 169.112 Section 169.112 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS General Provisions § 169.112 Special consideration. In applying the provisions of this part, the Officer in Charge...

  3. 46 CFR 169.112 - Special consideration.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Special consideration. 169.112 Section 169.112 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS General Provisions § 169.112 Special consideration. In applying the provisions of this part, the Officer in Charge...

  4. Low degree Earth's gravity coefficients determined from different space geodetic observations and climate models

    NASA Astrophysics Data System (ADS)

    Wińska, Małgorzata; Nastula, Jolanta

    2017-04-01

    Large scale mass redistribution and its transport within the Earth system causes changes in the Earth's rotation in space, gravity field and Earth's ellipsoid shape. These changes are observed in the ΔC21, ΔS21, and ΔC20 spherical harmonics gravity coefficients, which are proportional to the mass load-induced Earth rotational excitations. In this study, linear trend, decadal, inter-annual, and seasonal variations of low degree spherical harmonics coefficients of Earth's gravity field, determined from different space geodetic techniques, Gravity Recovery and Climate Experiment (GRACE), satellite laser ranging (SLR), Global Navigation Satellite System (GNSS), Earth rotation, and climate models, are examined. In this way, the contribution of each measurement technique to interpreting the low degree surface mass density of the Earth is shown. Especially, we evaluate an usefulness of several climate models from the Coupled Model Intercomparison Project phase 5 (CMIP5) to determine the low degree Earth's gravity coefficients using GRACE satellite observations. To do that, Terrestrial Water Storage (TWS) changes from several CMIP5 climate models are determined and then these simulated data are compared with the GRACE observations. Spherical harmonics ΔC21, ΔS21, and ΔC20 changes are calculated as the sum of atmosphere and ocean mass effect (GAC values) taken from GRACE and a land surface hydrological estimate from the selected CMIP5 climate models. Low degree Stokes coefficients of the surface mass density determined from GRACE, SLR, GNSS, Earth rotation measurements and climate models are compared to each other in order to assess their consistency. The comparison is done by using different types of statistical and signal processing methods.

  5. Multi-level influence of school norms on tobacco use in South Africa: an ecometric consideration of group differences.

    PubMed

    Gilreath, Tamika D; Chaix, Basile; King, Gary; Matthews, Stephen; Flisher, Alan J

    2012-03-01

    Tobacco use has been found to be related to contextual-environmental characteristics. This study focuses on the influence of contextual norms on adolescent smoking behavior with consideration of racial differences. Data for this study were derived from the South African Community Epidemiology Network on Drug Use survey. Students (n = 1,277) completed a self-administered questionnaire (available in Afrikaans, Xhosa, and English). School-level aggregate measures were developed from the items: whether they thought smoking was wrong, whether they thought they would be seen as "cool" if they smoked, how many of their closest friends smoked, and whether they had repeated a grade level in school. The results of this analysis revealed that after controlling for demographic characteristics, aggregate measures of importance for ever smoking were whether there were school norms of perceiving that smoking was not wrong, perceiving that smoking was cool, and high prevalence of having friends who smoke. Recent smoking was only predicted by attendance at schools with increased levels of academic failure. Black South Africans were less likely to ever smoke than Coloured or White. This study highlights the saliency of both compositional (academic failure) and ecological (collective perceptions about smoking) characteristics in predicting ever and recent smoking. Collective perceptions of smoking in a predominantly Black school were largely negative. These findings can be used to target school norms regarding tobacco use in Cape Town.

  6. 32 CFR 215.4 - Legal considerations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Legal considerations. 215.4 Section 215.4...) MISCELLANEOUS EMPLOYMENT OF MILITARY RESOURCES IN THE EVENT OF CIVIL DISTURBANCES § 215.4 Legal considerations... the Federal Government at the local level, there are additional legal limits upon the use of military...

  7. 32 CFR 215.4 - Legal considerations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Legal considerations. 215.4 Section 215.4...) MISCELLANEOUS EMPLOYMENT OF MILITARY RESOURCES IN THE EVENT OF CIVIL DISTURBANCES § 215.4 Legal considerations... the Federal Government at the local level, there are additional legal limits upon the use of military...

  8. 32 CFR 215.4 - Legal considerations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Legal considerations. 215.4 Section 215.4...) MISCELLANEOUS EMPLOYMENT OF MILITARY RESOURCES IN THE EVENT OF CIVIL DISTURBANCES § 215.4 Legal considerations... the Federal Government at the local level, there are additional legal limits upon the use of military...

  9. 32 CFR 215.4 - Legal considerations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Legal considerations. 215.4 Section 215.4...) MISCELLANEOUS EMPLOYMENT OF MILITARY RESOURCES IN THE EVENT OF CIVIL DISTURBANCES § 215.4 Legal considerations... the Federal Government at the local level, there are additional legal limits upon the use of military...

  10. 32 CFR 215.4 - Legal considerations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Legal considerations. 215.4 Section 215.4...) MISCELLANEOUS EMPLOYMENT OF MILITARY RESOURCES IN THE EVENT OF CIVIL DISTURBANCES § 215.4 Legal considerations... the Federal Government at the local level, there are additional legal limits upon the use of military...

  11. 49 CFR 209.329 - Assessment considerations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... frequently repeated; (2) The adverse impact or the potentially adverse impact of the violation on the health... 49 Transportation 4 2010-10-01 2010-10-01 false Assessment considerations. 209.329 Section 209.329... Assessment considerations. (a) Proof of a respondent's willful violation of one of the requirements of parts...

  12. 49 CFR 209.329 - Assessment considerations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... frequently repeated; (2) The adverse impact or the potentially adverse impact of the violation on the health... 49 Transportation 4 2014-10-01 2014-10-01 false Assessment considerations. 209.329 Section 209.329... Assessment considerations. (a) Proof of a respondent's willful violation of one of the requirements of parts...

  13. 49 CFR 209.329 - Assessment considerations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... frequently repeated; (2) The adverse impact or the potentially adverse impact of the violation on the health... 49 Transportation 4 2013-10-01 2013-10-01 false Assessment considerations. 209.329 Section 209.329... Assessment considerations. (a) Proof of a respondent's willful violation of one of the requirements of parts...

  14. 49 CFR 209.329 - Assessment considerations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... frequently repeated; (2) The adverse impact or the potentially adverse impact of the violation on the health... 49 Transportation 4 2012-10-01 2012-10-01 false Assessment considerations. 209.329 Section 209.329... Assessment considerations. (a) Proof of a respondent's willful violation of one of the requirements of parts...

  15. 49 CFR 209.329 - Assessment considerations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... frequently repeated; (2) The adverse impact or the potentially adverse impact of the violation on the health... 49 Transportation 4 2011-10-01 2011-10-01 false Assessment considerations. 209.329 Section 209.329... Assessment considerations. (a) Proof of a respondent's willful violation of one of the requirements of parts...

  16. 12 CFR 508.11 - Relevant considerations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Relevant considerations. 508.11 Section 508.11 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 508.11 Relevant considerations. (a) In determining whether...

  17. Facility Design Considerations.

    ERIC Educational Resources Information Center

    Chase, William W.

    1967-01-01

    Increasing need for vocational education under the impetus of federal aid is generating a demand for vocational teaching facilities. Factors to be considered in planning these facilities inclued--(1) site development, (2) program needs, (3) administrative considerations, (4) environmental controls. (5) mechanical systems, and (6) area and space…

  18. Are Age-Related Differences Uniform Across Different Inhibitory Functions?

    PubMed

    Vadaga, Kiran K; Blair, Mervin; Li, Karen Z H

    2016-07-01

    In the current experiment, we examined the relative age-sensitivity of 3 inhibitory functions: access, deletion, and restraint by taking into consideration their underlying control processes: proactive and reactive control. The 3 inhibitory functions were measured using a sequential flanker task. Young (age: 18-35, n = 24) and older adults (age: 60-75, n = 25) first memorized a series of 8 animal words in a fixed order. In the test phase, these stimuli were presented randomly either singly or with flankers and participants responded "yes" or "no" based on the prelearned sequence. In the access trials, flankers were either ahead of the current target or unrelated. In the deletion trials, flankers were previous target items. In the restraint trials, the flanker cues (XXXX) prompted the participants to withhold responses occasionally. Unflanked trials served as the baseline condition. Age-related differences in the magnitude of inhibition effects were largest in restraint, followed by deletion. No age-related differences were observed in access. Our findings suggest that the magnitude of age-related differences in inhibitory functions is contingent on the degree of proactive control recruited by a given inhibitory function. © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  19. Can cultural differences lead to accidents? Team cultural differences and sociotechnical system operations.

    PubMed

    Strauch, Barry

    2010-04-01

    I discuss cultural factors and how they may influence sociotechnical system operations. Investigations of several major transportation accidents suggest that cultural factors may have played a role in the causes of the accidents. However, research has not fully addressed how cultural factors can influence sociotechnical systems. I review literature on cultural differences in general and cultural factors in sociotechnical systems and discuss how these differences can affect team performance in sociotechnical systems. Cultural differences have been observed in social and interpersonal dimensions and in cognitive and perceptual styles; these differences can affect multioperator team performance. Cultural factors may account for team errors in sociotechnical systems, most likely during high-workload, high-stress operational phases. However, much of the research on cultural factors has methodological and interpretive shortcomings that limit their applicability to sociotechnical systems. Although some research has been conducted on the role of cultural differences on team performance in sociotechnical system operations, considerable work remains to be done before the effects of these differences can be fully understood. I propose a model that illustrates how culture can interact with sociotechnical system operations and suggest avenues of future research. Given methodological challenges in measuring cultural differences and team performance in sociotechnical system operations, research in these systems should use a variety of methodologies to better understand how culture can affect multioperator team performance in these systems.

  20. Photovoltaic central station step and touch potential considerations in grounding system design

    NASA Technical Reports Server (NTRS)

    Engmann, G.

    1983-01-01

    The probability of hazardous step and touch potentials is an important consideration in central station grounding system design. Steam turbine generating station grounding system design is based on accepted industry practices and there is extensive in-service experience with these grounding systems. A photovoltaic (PV) central station is a relatively new concept and there is limited experience with PV station grounding systems. The operation and physical configuration of a PV central station is very different from a steam electric station. A PV station bears some similarity to a substation and the PV station step and touch potentials might be addressed as they are in substation design. However, the PV central station is a generating station and it is appropriate to examine the effect that the differences and similarities of the two types of generating stations have on step and touch potential considerations.

  1. 48 CFR 32.005 - Consideration for contract financing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Consideration for contract... GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING 32.005 Consideration for contract financing. (a... separate consideration for the contract financing clause. The value of the contract financing to the...

  2. Patients' and observers' perceptions of involvement differ. Validation study on inter-relating measures for shared decision making.

    PubMed

    Kasper, Jürgen; Heesen, Christoph; Köpke, Sascha; Fulcher, Gary; Geiger, Friedemann

    2011-01-01

    Patient involvement into medical decisions as conceived in the shared decision making method (SDM) is essential in evidence based medicine. However, it is not conclusively evident how best to define, realize and evaluate involvement to enable patients making informed choices. We aimed at investigating the ability of four measures to indicate patient involvement. While use and reporting of these instruments might imply wide overlap regarding the addressed constructs this assumption seems questionable with respect to the diversity of the perspectives from which the assessments are administered. The study investigated a nested cohort (N = 79) of a randomized trial evaluating a patient decision aid on immunotherapy for multiple sclerosis. Convergent validities were calculated between observer ratings of videotaped physician-patient consultations (OPTION) and patients' perceptions of the communication (Shared Decision Making Questionnaire, Control Preference Scale & Decisional Conflict Scale). OPTION reliability was high to excellent. Communication performance was low according to OPTION and high according to the three patient administered measures. No correlations were found between observer and patient judges, neither for means nor for single items. Patient report measures showed some moderate correlations. Existing SDM measures do not refer to a single construct. A gold standard is missing to decide whether any of these measures has the potential to indicate patient involvement. Pronounced heterogeneity of the underpinning constructs implies difficulties regarding the interpretation of existing evidence on the efficacy of SDM. Consideration of communication theory and basic definitions of SDM would recommend an inter-subjective focus of measurement. Controlled-Trials.com ISRCTN25267500.

  3. Observed Differences between North American Snow Extent and Snow Depth Variability

    NASA Astrophysics Data System (ADS)

    Ge, Y.; Gong, G.

    2006-12-01

    Snow extent and snow depth are two related characteristics of a snowpack, but they need not be mutually consistent. Differences between these two variables at local scales are readily apparent. However at larger scales which interact with atmospheric circulation and climate, snow extent is typically the variable used, while snow depth is often assumed to be minor and/or mutually consistent compared to snow extent, though this is rarely verified. In this study, a new regional/continental-scale gridded dataset derived from field observations is utilized to quantitatively evaluate the relationship between snow extent and snow depth over North America. Various statistical methods are applied to assess the mutual consistency of monthly snow depth vs. snow extent, including correlations, composites and principal components. Results indicate that snow depth variations are significant in their own rights, and that depth and extent anomalies are largely unrelated, especially over broad high latitude regions north of the snowline. In the vicinity of the snowline, where precipitation and ablation can affect both snow extent and snow depth, the two variables vary concurrently, especially in autumn and spring. It is also found that deeper winter snow translates into larger snow-covered area in the subsequent spring/summer season, which suggests a possible influence of winter snow depth on summer climate. The observed lack of mutual consistency at continental/regional scales suggests that snowpack depth variations may be of sufficiently large magnitude, spatial scope and temporal duration to influence regional-hemispheric climate, in a manner unrelated to the more extensively studied snow extent variations.

  4. Observed Decrease of North American Winter Temperature Variability

    NASA Astrophysics Data System (ADS)

    Rhines, A. N.; Tingley, M.; McKinnon, K. A.; Huybers, P. J.

    2015-12-01

    There is considerable interest in determining whether temperature variability has changed in recent decades. Model ensembles project that extratropical land temperature variance will detectably decrease by 2070. We use quantile regression of station observations to show that decreasing variability is already robustly detectable for North American winter during 1979--2014. Pointwise trends from GHCND stations are mapped into a continuous spatial field using thin-plate spline regression, resolving small-scales while providing uncertainties accounting for spatial covariance and varying station density. We find that variability of daily temperatures, as measured by the difference between the 95th and 5th percentiles, has decreased markedly in winter for both daily minima and maxima. Composites indicate that the reduced spread of winter temperatures primarily results from Arctic amplification decreasing the meridional temperature gradient. Greater observed warming in the 5th relative to the 95th percentile stems from asymmetric effects of advection during cold versus warm days; cold air advection is generally from northerly regions that have experienced greater warming than western or southwestern regions that are generally sourced during warm days.

  5. Reservoirs for Comets: Compositional Differences Based on Infrared Observations

    NASA Astrophysics Data System (ADS)

    Disanti, Michael A.; Mumma, Michael J.

    Tracing measured compositions of comets to their origins continues to be of keen interest to cometary scientists and to dynamical modelers of Solar System formation and evolution. This requires building a taxonomy of comets from both present-day dynamical reservoirs: the Kuiper Belt (hereafter KB), sampled through observation of ecliptic comets (primarily Jupiter Family comets, or JFCs), and the Oort cloud (OC), represented observationally by the long-period comets and by Halley Family comets (HFCs). Because of their short orbital periods, JFCs are subjected to more frequent exposure to solar radiation compared with OC comets. The recent apparitions of the JFCs 9P/Tempel 1 and 73P/Schwassmann-Wachmann 3 permitted detailed observations of material issuing from below their surfaces—these comets added significantly to the compositional database on this dynamical class, which is under-represented in studies of cometary parent volatiles. This chapter reviews the latest techniques developed for analysis of high-resolution spectral observations from ˜2-5 μm, and compares measured abundances of native ices among comets. While no clear compositional delineation can be drawn along dynamical lines, interesting comparisons can be made. The sub-surface composition of comet 9P, as revealed by the Deep Impact ejecta, was similar to the majority of OC comets studied. Meanwhile, 73P was depleted in all native ices except HCN, similar to the disintegrated OC comet C/1999 S4 (LINEAR). These results suggest that 73P may have formed in the inner giant planets' region while 9P formed farther out or, alternatively, that both JFCs formed farther from the Sun but with 73P forming later in time.

  6. Reservoirs for Comets: Compositional Differences Based on Infrared Observations

    NASA Astrophysics Data System (ADS)

    Disanti, Michael A.; Mumma, Michael J.

    2008-07-01

    Tracing measured compositions of comets to their origins continues to be of keen interest to cometary scientists and to dynamical modelers of Solar System formation and evolution. This requires building a taxonomy of comets from both present-day dynamical reservoirs: the Kuiper Belt (hereafter KB), sampled through observation of ecliptic comets (primarily Jupiter Family comets, or JFCs), and the Oort cloud (OC), represented observationally by the long-period comets and by Halley Family comets (HFCs). Because of their short orbital periods, JFCs are subjected to more frequent exposure to solar radiation compared with OC comets. The recent apparitions of the JFCs 9P/Tempel 1 and 73P/Schwassmann-Wachmann 3 permitted detailed observations of material issuing from below their surfaces—these comets added significantly to the compositional database on this dynamical class, which is under-represented in studies of cometary parent volatiles. This chapter reviews the latest techniques developed for analysis of high-resolution spectral observations from ˜2 5 μm, and compares measured abundances of native ices among comets. While no clear compositional delineation can be drawn along dynamical lines, interesting comparisons can be made. The sub-surface composition of comet 9P, as revealed by the Deep Impact ejecta, was similar to the majority of OC comets studied. Meanwhile, 73P was depleted in all native ices except HCN, similar to the disintegrated OC comet C/1999 S4 (LINEAR). These results suggest that 73P may have formed in the inner giant planets’ region while 9P formed farther out or, alternatively, that both JFCs formed farther from the Sun but with 73P forming later in time.

  7. A Study on Feature of Eye Tracking in Difference of Skill Level during Observational Learning of Movement

    NASA Astrophysics Data System (ADS)

    Nuruki, Atsuo; Shimozono, Tomoyuki; Kawabata, Takuro; Yamada, Masafumi; Yunokuchi, Kazutomo; Maruyama, Atsuo

    Recently, it often said that it is one of the means that the observational learning promotes the acquisition of sports and athletic skills. We think that the inexperienced person can efficiently acquire athletic skills by using the observational method of the expert as an index of the observational method in the observational learning. Then, in the present study, the expert and inexperienced person's glance characteristic were compared, and it was examined whether the observational method of the expert was able to be used as an index of the observational method of the inexperienced person. The glance characteristics are a glance transition, glance total moved distance, the gazing duration, moreover glance moved distance and radial velocity between each gaze points. Additionally, we investigated whether there was a change in physical performance before and after the observational learning, and two different observational learning groups (the expert's observational method group, the free observation group). In result, it was clarified that the expert concentrated, observed a constant part of the movement, and the inexperienced person was observing the entire movement. Moreover, the result that glance total moved distance was shorter than the inexperienced person, and expert's gazing duration was longer than the inexperienced person. It was clarified that the expert was efficiently emphatically observing the point of the movement from these results. In addition, the inexperienced persons have advanced physical performance through the observational learning. Then the expert's observational method group advanced physical performance better than the free observation group. Therefore we suggested that the observational method of the expert be able to be used as an index of the method of observing the inexperienced person.

  8. Ethical considerations in adherence research.

    PubMed

    Patel, Nupur U; Moore, Blake A; Craver, Rebekah F; Feldman, Steven R

    2016-01-01

    Poor adherence to treatment is a common cause of medical treatment failure. Studying adherence is complicated by the potential for the study environment to impact adherence behavior. Studies performed without informing patients about adherence monitoring must balance the risks of deception against the potential benefits of the knowledge to be gained. Ethically monitoring a patient's adherence to a treatment plan without full disclosure of the monitoring plan requires protecting the patient's rights and upholding the fiduciary obligations of the investigator. Adherence monitoring can utilize different levels of deception varying from stealth monitoring, debriefing after the study while informing the subject that some information had been withheld in regard to the use of adherence monitoring (withholding), informed consent that discloses some form of adherence monitoring is being used and will be disclosed at the end of the study (authorized deception), and full disclosure. Different approaches offer different benefits and potential pitfalls. The approach used must balance the risk of nondisclosure against the potential for confounding the adherence monitoring data and the potential benefits that adherence monitoring data will have for the research subjects and/or other populations. This commentary aims to define various methods of adherence monitoring and to provide a discussion of the ethical considerations that accompany the use of each method and adherence monitoring in general as it is used in clinical research.

  9. The Comparability of the Standardized Mean Difference Effect Size across Different Measures of the Same Construct: Measurement Considerations

    ERIC Educational Resources Information Center

    Nugent, William R.

    2006-01-01

    One of the most important effect sizes used in meta-analysis is the standardized mean difference (SMD). In this article, the conditions under which SMD effect sizes based on different measures of the same construct are directly comparable are investigated. The results show that SMD effect sizes from different measures of the same construct are…

  10. Nutritional Considerations for Performance in Young Athletes

    PubMed Central

    Smith, JohnEric W.; Holmes, Megan E.; McAllister, Matthew J.

    2015-01-01

    Nutrition is an integral component to any athletes training and performance program. In adults the balance between energy intake and energy demands is crucial in training, recovery, and performance. In young athletes the demands for training and performance remain but should be a secondary focus behind the demands associated with maintaining the proper growth and maturation. Research interventions imposing significant physiological loads and diet manipulation are limited in youth due to the ethical considerations related to potential negative impacts on the growth and maturation processes associated with younger individuals. This necessary limitation results in practitioners providing nutritional guidance to young athletes to rely on exercise nutrition recommendations intended for adults. While many of the recommendations can appropriately be repurposed for the younger athlete attention needs to be taken towards the differences in metabolic needs and physiological differences. PMID:26464898

  11. Sex, race, and consideration of bariatric surgery among primary care patients with moderate to severe obesity.

    PubMed

    Wee, Christina C; Huskey, Karen W; Bolcic-Jankovic, Dragana; Colten, Mary Ellen; Davis, Roger B; Hamel, Marybeth

    2014-01-01

    Bariatric surgery is one of few obesity treatments to produce substantial weight loss but only a small proportion of medically-eligible patients, especially men and racial minorities, undergo bariatric surgery. To describe primary care patients' consideration of bariatric surgery, potential variation by sex and race, and factors that underlie any variation. Telephone interview of 337 patients with a body mass index or BMI > 35 kg/m(2) seen at four diverse primary care practices in Greater-Boston. Patients' consideration of bariatric surgery. Of 325 patients who had heard of bariatric surgery, 34 % had seriously considered surgery. Men were less likely than women and African Americans were less likely than Caucasian patients to have considered surgery after adjustment for sociodemographics and BMI. Comorbid conditions did not explain sex and racial differences but racial differences dissipated after adjustment for quality of life (QOL), which tended to be higher among African American than Caucasian patients. Physician recommendation of bariatric surgery was independently associated with serious consideration for surgery [OR 4.95 (95 % CI 2.81-8.70)], but did not explain variation in consideration of surgery across sex and race. However, if recommended by their doctor, men were as willing and African American and Hispanic patients were more willing to consider bariatric surgery than their respective counterparts after adjustment. Nevertheless, only 20 % of patients reported being recommended bariatric surgery by their doctor and African Americans and men were less likely to receive this recommendation; racial differences in being recommended surgery were also largely explained by differences in QOL. High perceived risk to bariatric surgery was the most commonly cited barrier; financial concerns were uncommonly cited. Single geographic region; examined consideration and not who eventually proceeded with bariatric surgery. African Americans and men were less likely to

  12. State/Federal Regulatory Considerations

    EPA Pesticide Factsheets

    This page contains presentations from the Brown to Green: Make the Connection to Renewable Energy workshop held in Santa Fe, New Mexico, during December 10-11, 2008, regarding State/Federal Regulatory Considerations.

  13. Obtaining coincident image observations for Mission to Planet Earth science data return

    NASA Technical Reports Server (NTRS)

    Newman, Lauri Kraft; Folta, David C.; Farrell, James P.

    1994-01-01

    One objective of the Mission to Planet Earth (MTPE) program involves comparing data from various instruments on multiple spacecraft to obtain a total picture of the Earth's systems. To correlate image data from instruments on different spacecraft, these spacecraft must be able to image the same location on the Earth at approximately the same time. Depending on the orbits of the spacecraft involved, complicated operational details must be considered to obtain such observations. If the spacecraft are in similar orbits, close formation flying or synchronization techniques may be used to assure coincident observations. If the orbits are dissimilar, the launch time of the second satellite may need to be restricted in order to align its orbit with that of the first satellite launched. This paper examines strategies for obtaining coincident observations for spacecraft in both similar and dissimilar orbits. Although these calculations may be performed easily for coplanar spacecraft, the non-coplanar case involves additional considerations which are incorporated into the algorithms presented herein.

  14. Effect of observation on lower limb prosthesis gait biomechanics: Preliminary results.

    PubMed

    Malchow, Connor; Fiedler, Goeran

    2016-12-01

    The Hawthorne effect, a subcategory of reactivity, causes human behavior to change when under observation. Such an effect may apply to gait variation of persons with prosthetics or orthotics devices. This study investigated whether the presence of observers directly affects the gait pattern of users of lower limb prostheses. Within-subject intervention study. Primary outcome measures were gait parameters of initial double support time and upper body lateral tilt angle, which were collected with a mobile sensor attached to the subjects' back. To make subjects feel unwatched, a certain amount of deception was necessary, and two different conditions were created and statistically compared against each other: one in which the subjects were initially unaware of the attention of observers and another one in which the same subjects were aware of a group of observers. Data from two subjects using trans-femoral prosthesis are reported. Findings included a change in step initial double support percentage by up to 14.2% (p = 0.019). Considerable changes were also noted in secondary outcome measures including speed, stride length, and stride symmetry. A reactivity effect of observation exists in prosthetics gait analysis. More comprehensive studies may be motivated by these preliminary findings. Results of this study suggest that users of lower limb prostheses walk differently when their gait is being assessed (e.g. in the prosthetist's office) than in situations without observers. This may in part explain the clinical experience that modifications of prosthetic fit or alignment provide only short-term betterment. © The International Society for Prosthetics and Orthotics 2015.

  15. Evaluation of Detector-to-Detector and Mirror Side Differences for Terra MODIS Reflective Solar Bands Using Simultaneous MISR Observations

    NASA Technical Reports Server (NTRS)

    Wu, Aisheng; Xiong, Xiaoxiong; Angal, A.; Barnes, W.

    2011-01-01

    The Moderate Resolution Imaging Spectroradiometer (MODIS) is one of the five Earth-observing instruments on-board the National Aeronautics and Space Administration (NASA) Earth-Observing System(EOS) Terra spacecraft, launched in December 1999. It has 36 spectral bands with wavelengths ranging from 0.41 to 14.4 mm and collects data at three nadir spatial resolutions: 0.25 km for 2 bands with 40 detectors each, 0.5 km for 5 bands with 20 detectors each and 1 km for the remaining 29 bands with 10 detectors each. MODIS bands are located on four separate focal plane assemblies (FPAs) according to their spectral wavelengths and aligned in the cross-track direction. Detectors of each spectral band are aligned in the along-track direction. MODIS makes observations using a two-sided paddle-wheel scan mirror. Its on-board calibrators (OBCs) for the reflective solar bands (RSBs) include a solar diffuser (SD), a solar diffuser stability monitor (SDSM) and a spectral-radiometric calibration assembly (SRCA). Calibration is performed for each band, detector, sub-sample (for sub-kilometer resolution bands) and mirror side. In this study, a ratio approach is applied to MODIS observed Earth scene reflectances to track the detector-to-detector and mirror side differences. Simultaneous observed reflectances from the Multi-angle Imaging Spectroradiometer (MISR), also onboard the Terra spacecraft, are used with MODIS observed reflectances in this ratio approach for four closely matched spectral bands. Results show that the detector-to-detector difference between two adjacent detectors within each spectral band is typically less than 0.2% and, depending on the wavelengths, the maximum difference among all detectors varies from 0.5% to 0.8%. The mirror side differences are found to be very small for all bands except for band 3 at 0.44 mm. This is the band with the shortest wavelength among the selected matching bands, showing a time-dependent increase for the mirror side difference. This

  16. Are There Clinical Implications of Racial Differences in HbA1c? A Difference, to Be a Difference, Must Make a Difference

    PubMed Central

    Selvin, Elizabeth

    2016-01-01

    Studies that have compared HbA1c levels by race have consistently demonstrated higher HbA1c levels in African Americans than in whites. These racial differences in HbA1c have not been explained by measured differences in glycemia, sociodemographic factors, clinical factors, access to care, or quality of care. Recently, a number of nonglycemic factors and several genetic polymorphisms that operate through nonglycemic mechanisms have been associated with HbA1c. Their distributions across racial groups and their impact on hemoglobin glycation need to be systematically explored. Thus, on the basis of evidence for racial differences in HbA1c, current clinical guidelines from the American Diabetes Association state: “It is important to take…race/ethnicity…into consideration when using the A1C to diagnose diabetes.” However, it is not clear from the guidelines how this recommendation might be actualized. So, the critical question is not whether racial differences in HbA1c exist between African Americans and whites; the important question is whether the observed differences in HbA1c level are clinically meaningful. Therefore, given the current controversy, we provide a Point-Counterpoint debate on this issue. In the preceding point narrative, Dr. Herman provides his argument that the failure to acknowledge that HbA1c might be a biased measure of average glycemia and an unwillingness to rigorously investigate this hypothesis will slow scientific progress and has the potential to do great harm. In the counterpoint narrative below, Dr. Selvin argues that there is no compelling evidence for racial differences in the validity of HbA1c as a measure of hyperglycemia and that race is a poor surrogate for differences in underlying causes of disease risk. —William T. Cefalu Editor in Chief, Diabetes Care PMID:27457637

  17. Testing Collisional Scaling Laws: Comparing with Observables

    NASA Astrophysics Data System (ADS)

    Davis, D. R.; Marzari, F.; Farinella, P.

    1999-09-01

    How large bodies break up in response to energetic collisions is a problem that has attracted considerable attention in recent years. Ever more sophisticated computation methods have also been developed; prominent among these are hydrocode simulations of collisional disruption by Benz and Asphaug (1999, Icarus, in press), Love and Ahrens (1996, LPSC XXVII, 777-778), and Melosh and Ryan (1997, Icarus 129, 562-564). Durda et al. (1998, Icarus 135, 431-440) used the observed asteroid size distribution to infer a scaling algorithm. The present situation is that there are several proposed scaling laws that differ by as much as two orders of magnitude at particular sizes. We have expanded upon the work of Davis et al. (1994, Goutelas Proceedings) and tested the suite of proposed scaling algorithms against observations of the main-belt asteroids. The effects of collisions among the asteroids produce the following observables: (a) the size distribution has been significantly shaped by collisions, (b) collisions have produced about 25 well recognized asteroid families, and (c) the basaltic crust of Vesta has been largely preserved in the face of about 4.5 Byr of impacts. We will present results from a numerical simulation of asteroid collisional evolution over the age of the solar system using proposed scaling laws and a range of hypothetical initial populations.

  18. Different Rights, Different Perspectives: Observations on the Same-Sex Marriage Debate.

    ERIC Educational Resources Information Center

    Howard, J. Paul R.

    2003-01-01

    The Ontario and British Columbia courts of appeal have held that the restriction of marriage to heterosexuals is unconstitutional. Opposing views in same-sex marriage litigation arise from different definitions of "marriage." Proposed federal legislation would legalize same-sex marriage but not resolve the larger, underlying issue of how…

  19. The private duty market: operational and staffing considerations.

    PubMed

    Considine, C J

    2000-01-01

    Wouldn't it be nice to get away from Medicare home health regulations and into a business where the provider simply needs an understanding of the difference between a revenue and an expense? Cost reports, disallowances, allocations, cost shifts, and cost limits become a thing of the past. This article will help you plan and evaluate your approach to developing a private duty business. An overview of the market, operational considerations, and a discussion of various key staff positions and their functions allows you to explore this opportunity from many vantage points.

  20. Clinical Considerations in Treating BDSM Practitioners: A Review.

    PubMed

    Dunkley, Cara R; Brotto, Lori A

    2018-03-15

    BDSM is an overlapping acronym referring to the practices of bondage and discipline, dominance and submission, and sadism and masochism. This article reviews the psychological literature on BDSM practitioners and discusses issues concerning BDSM that are relevant to clinicians and sexual health-care providers. The literature concerning the psychological health of BDSM practitioners and clinical issues in treating BDSM practitioners was exhaustively reviewed. BDSM practitioners differ minimally from the general population in terms of psychopathology. Six clinical considerations emerged: ignoring versus considering BDSM; countertransference; nondisclosure; cultural competence; closer relationship dynamics; BDSM, abuse, and pathology.

  1. Gender difference in the response to valsartan/amlodipine single-pill combination in essential hypertension (China Status II): An observational study

    PubMed Central

    Wang, Huan; Chen, Hui

    2016-01-01

    Background: The China STATUS II is a prospective, multicentre, open-label, post-marketing, observational study including Chinese adults (aged ⩾ 18 years) with essential hypertension who were prescribed once-daily valsartan/amlodipine (Val/Aml 80/5 mg) single-pill combination. In order to examine gender differences in treatment response to Val/Aml, we further analysed data from the China STATUS II study. Methods: A total of 11,312 patients (6456 (57%) men and 4856 (43%) women) received the Val/Aml treatment for 8 weeks. After the treatment, we compared the proportion of patients not achieving the target systolic blood pressure (SBP: < 140 mm Hg) or diastolic blood pressure (DBP: < 90 mm Hg) in different age groups (by Fisher exact probability test) and estimated the changes in blood pressure (BP) according to age and gender, using a mixed model. Results: At enrolment, mean SBP was higher in the female versus the male patients (160.0 ± 12.71 versus 159.3 ± 12.31 mm Hg; p = 0.003), whereas the mean DBP was higher in the male versus the female patients (96.4 ± 10.65 versus 94.5 ± 10.72 mm Hg; p < 0.001). The overall proportion of women not achieving the target BP was less than that of men (57.41% versus 59.59%; p < 0.05) at 4 weeks and (22.22% versus 23.78%; p < 0.05) at 8 weeks after the Val/Aml treatment. Among both men and women, the proportion of patients not achieving the target SBP increased with age; however, the proportion not achieving the target DBP decreased with age. The mixed-model analysis showed that the changes in SBP were closely related to gender, indicating that the SBP-lowering effect after Val/Aml treatment might be better in women. In addition, the changes in DBP were closely related to age. Conclusions: Gender might be a factor for consideration in the decision-making process of individualised antihypertensive therapy, in the future. PMID:27127102

  2. Gender difference in the response to valsartan/amlodipine single-pill combination in essential hypertension (China Status II): An observational study.

    PubMed

    Wang, Huan; Chen, Hui

    2016-01-01

    The China STATUS II is a prospective, multicentre, open-label, post-marketing, observational study including Chinese adults (aged ⩾ 18 years) with essential hypertension who were prescribed once-daily valsartan/amlodipine (Val/Aml 80/5 mg) single-pill combination. In order to examine gender differences in treatment response to Val/Aml, we further analysed data from the China STATUS II study. A total of 11,312 patients (6456 (57%) men and 4856 (43%) women) received the Val/Aml treatment for 8 weeks. After the treatment, we compared the proportion of patients not achieving the target systolic blood pressure (SBP: < 140 mm Hg) or diastolic blood pressure (DBP: < 90 mm Hg) in different age groups (by Fisher exact probability test) and estimated the changes in blood pressure (BP) according to age and gender, using a mixed model. At enrolment, mean SBP was higher in the female versus the male patients (160.0 ± 12.71 versus 159.3 ± 12.31 mm Hg; p = 0.003), whereas the mean DBP was higher in the male versus the female patients (96.4 ± 10.65 versus 94.5 ± 10.72 mm Hg; p < 0.001). The overall proportion of women not achieving the target BP was less than that of men (57.41% versus 59.59%; p < 0.05) at 4 weeks and (22.22% versus 23.78%; p < 0.05) at 8 weeks after the Val/Aml treatment. Among both men and women, the proportion of patients not achieving the target SBP increased with age; however, the proportion not achieving the target DBP decreased with age. The mixed-model analysis showed that the changes in SBP were closely related to gender, indicating that the SBP-lowering effect after Val/Aml treatment might be better in women. In addition, the changes in DBP were closely related to age. Gender might be a factor for consideration in the decision-making process of individualised antihypertensive therapy, in the future. © The Author(s) 2016.

  3. GNSS Derived Ionospheric TEC Observed Through Different TEC Calibration Techniques in the Brazilian Sector

    NASA Astrophysics Data System (ADS)

    Becker-Guedes, F.; Carmo, C. S.; Camargo, P. O.; Monico, J. F. G.; Nicoli Candido, C. M.

    2017-12-01

    Global Navigation Satellite System (GNSS) is becoming a reliable tool for use in air navigation systems. Its use as the main technology for determination of airplanes positioning has various economic and logistic benefits but it depends strongly on the ionospheric layer influences. The Brazilian sector ionosphere, mainly over the equatorial ionization anomaly (EIA), presents remarkable errors in the GNSS signal as compared to North America and Europe. In order to study the total electron content latitudinal variation of the Brazilian ionosphere we used a pair of GNSS receivers on the ground, one located in the equatorial region (Sao Luis) and other in the southern crest of the EIA (Cachoeira Paulista), to collect the GNSS observables and calculate the vertical TEC using different methods that has proven to work well to describe the ionospheric behavior in the North America and in Europe. We compared this results with a modified Nagoya TEC calculation method used by the EMBRACE (Estudo e Monitoramento BRAsileiro do Clima Espacial - Brazilian Study and Monitoring of Space Weather) program. This work intends to follow the performance of different TEC tuning methods to evaluate the spurious effects of the ionospheric EIA gradients in the TEC determination under typical conditions of the low-latitudes ionosphere in the Brazilian sector. The calculated TEC under different solar cycle conditions, geomagnetic activity, and seasonal variations show deviations in the performance of each method and stress the importance of well adjust the GNSS observations to local conditions in order to optimize the TEC evaluation. This study contributes to a better understanding of local GNSS signal errors in the global intent of offering conditions to improve the accuracy, integrity, availability, and continuity requirements for the use of GNSS for air navigation in South America.

  4. 17 CFR 39.27 - Legal risk considerations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 1 2014-04-01 2014-04-01 false Legal risk considerations. 39... CLEARING ORGANIZATIONS Compliance with Core Principles § 39.27 Legal risk considerations. (a) Legal... by the appropriate foreign licensing authority. (b) Legal framework. A derivatives clearing...

  5. Neurophysiological tools to investigate consumer's gender differences during the observation of TV commercials.

    PubMed

    Vecchiato, Giovanni; Maglione, Anton Giulio; Cherubino, Patrizia; Wasikowska, Barbara; Wawrzyniak, Agata; Latuszynska, Anna; Latuszynska, Malgorzata; Nermend, Kesra; Graziani, Ilenia; Leucci, Maria Rita; Trettel, Arianna; Babiloni, Fabio

    2014-01-01

    Neuromarketing is a multidisciplinary field of research whose aim is to investigate the consumers' reaction to advertisements from a neuroscientific perspective. In particular, the neuroscience field is thought to be able to reveal information about consumer preferences which are unobtainable through conventional methods, including submitting questionnaires to large samples of consumers or performing psychological personal or group interviews. In this scenario, we performed an experiment in order to investigate cognitive and emotional changes of cerebral activity evaluated by neurophysiologic indices during the observation of TV commercials. In particular, we recorded the electroencephalographic (EEG), galvanic skin response (GSR), and heart rate (HR) in a group of 28 healthy subjects during the observation of a series of TV advertisements that have been grouped by commercial categories. Comparisons of cerebral indices have been performed to highlight gender differences between commercial categories and scenes of interest of two specific commercials. Findings show how EEG methodologies, along with the measurements of autonomic variables, could be used to obtain hidden information to marketers not obtainable otherwise. Most importantly, it was suggested how these tools could help to analyse the perception of TV advertisements and differentiate their production according to the consumer's gender.

  6. Neurophysiological Tools to Investigate Consumer's Gender Differences during the Observation of TV Commercials

    PubMed Central

    Maglione, Anton Giulio; Wasikowska, Barbara; Wawrzyniak, Agata; Graziani, Ilenia; Trettel, Arianna

    2014-01-01

    Neuromarketing is a multidisciplinary field of research whose aim is to investigate the consumers' reaction to advertisements from a neuroscientific perspective. In particular, the neuroscience field is thought to be able to reveal information about consumer preferences which are unobtainable through conventional methods, including submitting questionnaires to large samples of consumers or performing psychological personal or group interviews. In this scenario, we performed an experiment in order to investigate cognitive and emotional changes of cerebral activity evaluated by neurophysiologic indices during the observation of TV commercials. In particular, we recorded the electroencephalographic (EEG), galvanic skin response (GSR), and heart rate (HR) in a group of 28 healthy subjects during the observation of a series of TV advertisements that have been grouped by commercial categories. Comparisons of cerebral indices have been performed to highlight gender differences between commercial categories and scenes of interest of two specific commercials. Findings show how EEG methodologies, along with the measurements of autonomic variables, could be used to obtain hidden information to marketers not obtainable otherwise. Most importantly, it was suggested how these tools could help to analyse the perception of TV advertisements and differentiate their production according to the consumer's gender. PMID:25147579

  7. TRMM Observations of Polarization Difference in 85 GHz: Information About Hydrometeors and Rain Rate

    NASA Technical Reports Server (NTRS)

    Prabhakara, C.; Iacovazzi, R., Jr.; Yoo, J.-M.; Einaudi, Franco (Technical Monitor)

    2000-01-01

    Observations made by the Precipitation Radar (PR) and the Microwave Imager (TMI) radiometer on board the Tropical Rainfall Measuring Mission (TRMM) satellite help us to show the significance of the 85 GHz polarization difference, PD85, measured by TMI. Rain type, convective or stratiform, deduced from the PR allows us to infer that PD85 is generally positive in stratiform rain clouds, while PD85 can be markedly negative in deep convective rain clouds. Furthermore, PD85 increases in a gross manner as stratiform rain rate increases. On the contrary, in a crude fashion PD85 decreases as convective rain rate increases. From the observations of TMI and PR, we find that PD85 is a weak indicator of rain rate. Utilizing information from existing polarimetric radar studies, we infer that negative values of PD85 are likely associated with vertically-oriented small oblate or wet hail that are found in deep convective updrafts.

  8. Consideration of drainage ditches and sediment rating cure on SWAT model performance

    USDA-ARS?s Scientific Manuscript database

    Water quality models most often require a considerable amount of data to be properly configured and in some cases this requires additional procedural steps prior to model applications. We examined two different scenarios of such input issues in a small watershed using the Soil and Water Assessment ...

  9. Osteoporosis therapies: evidence from health-care databases and observational population studies.

    PubMed

    Silverman, Stuart L

    2010-11-01

    Osteoporosis is a well-recognized disease with severe consequences if left untreated. Randomized controlled trials are the most rigorous method for determining the efficacy and safety of therapies. Nevertheless, randomized controlled trials underrepresent the real-world patient population and are costly in both time and money. Modern technology has enabled researchers to use information gathered from large health-care or medical-claims databases to assess the practical utilization of available therapies in appropriate patients. Observational database studies lack randomization but, if carefully designed and successfully completed, can provide valuable information that complements results obtained from randomized controlled trials and extends our knowledge to real-world clinical patients. Randomized controlled trials comparing fracture outcomes among osteoporosis therapies are difficult to perform. In this regard, large observational database studies could be useful in identifying clinically important differences among therapeutic options. Database studies can also provide important information with regard to osteoporosis prevalence, health economics, and compliance and persistence with treatment. This article describes the strengths and limitations of both randomized controlled trials and observational database studies, discusses considerations for observational study design, and reviews a wealth of information generated by database studies in the field of osteoporosis.

  10. 17 CFR 39.27 - Legal risk considerations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... operations, risk management procedures, and related requirements. (c) Conflict of laws. If a derivatives... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false Legal risk considerations. 39... CLEARING ORGANIZATIONS Compliance with Core Principles § 39.27 Legal risk considerations. (a) Legal...

  11. 17 CFR 39.27 - Legal risk considerations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... operations, risk management procedures, and related requirements. (c) Conflict of laws. If a derivatives... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Legal risk considerations. 39... CLEARING ORGANIZATIONS Compliance with Core Principles § 39.27 Legal risk considerations. (a) Legal...

  12. 20 CFR 322.4 - Consideration of evidence.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Consideration of evidence. 322.4 Section 322.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.4 Consideration of evidence. (a) Initial proof. A claimant's certification...

  13. 20 CFR 322.4 - Consideration of evidence.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Consideration of evidence. 322.4 Section 322.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.4 Consideration of evidence. (a) Initial proof. A claimant's certification...

  14. 20 CFR 322.4 - Consideration of evidence.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Consideration of evidence. 322.4 Section 322.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.4 Consideration of evidence. (a) Initial proof. A claimant's certification...

  15. Topical Review: Families Coping With Child Trauma: A Naturalistic Observation Methodology.

    PubMed

    Alisic, Eva; Barrett, Anna; Bowles, Peter; Conroy, Rowena; Mehl, Matthias R

    2016-01-01

    To introduce a novel, naturalistic observational methodology (the Electronically Activated Recorder; EAR) as an opportunity to better understand the central role of the family environment in children's recovery from trauma. Discussion of current research methods and a systematic literature review of EAR studies on health and well-being. Surveys, experience sampling, and the EAR method each provide different opportunities and challenges for studying family interactions. We identified 17 articles describing relevant EAR studies. These investigated questions of emotional well-being, communicative behaviors, and interpersonal relationships, predominantly in adults. 5 articles reported innovative research in children, triangulating EAR-observed behavioral data (e.g., on child conflict at home) with neuroendocrine assay, sociodemographic information, and parent report. Finally, we discussed psychometric, practical, and ethical considerations for conducting EAR research with children and families. Naturalistic observation methods such as the EAR have potential for pediatric psychology studies regarding trauma and the family environment. © The Author 2015. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  16. Sex differences in the outcomes of stent implantation in mini-swine model.

    PubMed

    Kunio, Mie; Wong, Gee; Markham, Peter M; Edelman, Elazer R

    2018-01-01

    Sex-related differences have been noted in cardiovascular anatomy, pathophysiology, and treatment responses, yet we continued to drive evaluation of vascular device development in animal models without consideration of animal sex. We aimed to understand sex-related differences in the vascular responses to stent implantation by analyzing the pooled data of endovascular interventions in 164 Yucatan mini-swine (87 female, 77 male). Bare metal stents (BMS) or drug-eluting stents (DES) were implanted in 212 coronary arteries (63 single BMS implantation, 68 single DES implantation, 33 overlapped BMS implantation, and 48 overlapped DES implantation). Histomorphological parameters were evaluated from vascular specimens at 3-365 days after stent implantation and evaluated values were compared between female and male groups. While neointima formation at all times after implantation was invariant to sex, statistically significant differences between female and male groups were observed in injury, inflammation, adventitial fibrosis, and neointimal fibrin deposition. These differences were observed independently, i.e., for different procedure types and at different follow-up timings. Only subtle temporal sex-related differences were observed in extent and timing of resolution of inflammation and fibrin clearance. These subtle sex-related differences may be increasingly important as interventional devices meld novel materials that erode and innovations in drug delivery. Erodible materials may act differently if inflammation has a different temporal sequence with sex, and drug distribution after balloon or stent delivery might be different if the fibrin clearance speaks to different modes of pharmacokinetics in male and female swine.

  17. The Effects of Different Types of Anchor Tests on Observed Score Equating. Research Report. ETS RR-09-41

    ERIC Educational Resources Information Center

    Liu, Jinghua; Sinharay, Sandip; Holland, Paul W.; Feigenbaum, Miriam; Curley, Edward

    2009-01-01

    This study explores the use of a different type of anchor, a "midi anchor", that has a smaller spread of item difficulties than the tests to be equated, and then contrasts its use with the use of a "mini anchor". The impact of different anchors on observed score equating were evaluated and compared with respect to systematic…

  18. Bauhinia variegata leaf extracts exhibit considerable antibacterial, antioxidant, and anticancer activities.

    PubMed

    Mishra, Amita; Sharma, Amit Kumar; Kumar, Shashank; Saxena, Ajit K; Pandey, Abhay K

    2013-01-01

    The present study reports the phytochemical profiling, antimicrobial, antioxidant, and anticancer activities of Bauhinia variegata leaf extracts. The reducing sugar, anthraquinone, and saponins were observed in polar extracts, while terpenoids and alkaloids were present in nonpolar and ethanol extracts. Total flavonoid contents in various extracts were found in the range of 11-222.67 mg QE/g. In disc diffusion assays, petroleum ether and chloroform fractions exhibited considerable inhibition against Klebsiella pneumoniae. Several other extracts also showed antibacterial activity against pathogenic strains of E. coli, Proteus spp. and Pseudomonas spp. Minimum bactericidal concentration (MBC) values of potential extracts were found between 3.5 and 28.40 mg/mL. The lowest MBC (3.5 mg/mL) was recorded for ethanol extract against Pseudomonas spp. The antioxidant activity of the extracts was compared with standard antioxidants. Dose dependent response was observed in reducing power of extracts. Polar extracts demonstrated appreciable metal ion chelating activity at lower concentrations (10-40 μg/mL). Many extracts showed significant antioxidant response in beta carotene bleaching assay. AQ fraction of B. variegata showed pronounced cytotoxic effect against DU-145, HOP-62, IGR-OV-1, MCF-7, and THP-1 human cancer cell lines with 90-99% cell growth inhibitory activity. Ethyl acetate fraction also produced considerable cytotoxicity against MCF-7 and THP-1 cell lines. The study demonstrates notable antibacterial, antioxidant, and anticancer activities in B. variegata leaf extracts.

  19. Bauhinia variegata Leaf Extracts Exhibit Considerable Antibacterial, Antioxidant, and Anticancer Activities

    PubMed Central

    Mishra, Amita; Sharma, Amit Kumar; Kumar, Shashank; Saxena, Ajit K.; Pandey, Abhay K.

    2013-01-01

    The present study reports the phytochemical profiling, antimicrobial, antioxidant, and anticancer activities of Bauhinia variegata leaf extracts. The reducing sugar, anthraquinone, and saponins were observed in polar extracts, while terpenoids and alkaloids were present in nonpolar and ethanol extracts. Total flavonoid contents in various extracts were found in the range of 11–222.67 mg QE/g. In disc diffusion assays, petroleum ether and chloroform fractions exhibited considerable inhibition against Klebsiella pneumoniae. Several other extracts also showed antibacterial activity against pathogenic strains of E. coli, Proteus spp. and Pseudomonas spp. Minimum bactericidal concentration (MBC) values of potential extracts were found between 3.5 and 28.40 mg/mL. The lowest MBC (3.5 mg/mL) was recorded for ethanol extract against Pseudomonas spp. The antioxidant activity of the extracts was compared with standard antioxidants. Dose dependent response was observed in reducing power of extracts. Polar extracts demonstrated appreciable metal ion chelating activity at lower concentrations (10–40 μg/mL). Many extracts showed significant antioxidant response in beta carotene bleaching assay. AQ fraction of B. variegata showed pronounced cytotoxic effect against DU-145, HOP-62, IGR-OV-1, MCF-7, and THP-1 human cancer cell lines with 90–99% cell growth inhibitory activity. Ethyl acetate fraction also produced considerable cytotoxicity against MCF-7 and THP-1 cell lines. The study demonstrates notable antibacterial, antioxidant, and anticancer activities in B. variegata leaf extracts. PMID:24093108

  20. Lipid consumption in coral larvae differs among sites: a consideration of environmental history in a global ocean change scenario

    PubMed Central

    Chen, Chii-Shiarng; Fan, Tung-Yung; Li, Hsing-Hui

    2017-01-01

    The success of early life-history stages is an environmentally sensitive bottleneck for many marine invertebrates. Responses of larvae to environmental stress may vary due to differences in maternal investment of energy stores and acclimatization/adaptation of a population to local environmental conditions. In this study, we compared two populations from sites with different environmental regimes (Moorea and Taiwan). We assessed the responses of Pocillopora damicornis larvae to two future co-occurring environmental stressors: elevated temperature and ocean acidification. Larvae from Taiwan were more sensitive to temperature, producing fewer energy-storage lipids under high temperature. In general, planulae in Moorea and Taiwan responded similarly to pCO2. Additionally, corals in the study sites with different environments produced larvae with different initial traits, which may have shaped the different physiological responses observed. Notably, under ambient conditions, planulae in Taiwan increased their stores of wax ester and triacylglycerol in general over the first 24 h of their dispersal, whereas planulae from Moorea consumed energy-storage lipids in all cases. Comparisons of physiological responses of P. damicornis larvae to conditions of ocean acidification and warming between sites across the species' biogeographic range illuminates the variety of physiological responses maintained within P. damicornis, which may enhance the overall persistence of this species in the light of global climate change. PMID:28446693

  1. Similar exemplar pooling processes underlie the learning of facial identity and handwriting style: Evidence from typical observers and individuals with Autism.

    PubMed

    Ipser, Alberta; Ring, Melanie; Murphy, Jennifer; Gaigg, Sebastian B; Cook, Richard

    2016-05-01

    Considerable research has addressed whether the cognitive and neural representations recruited by faces are similar to those engaged by other types of visual stimuli. For example, research has examined the extent to which objects of expertise recruit holistic representation and engage the fusiform face area. Little is known, however, about the domain-specificity of the exemplar pooling processes thought to underlie the acquisition of familiarity with particular facial identities. In the present study we sought to compare observers' ability to learn facial identities and handwriting styles from exposure to multiple exemplars. Crucially, while handwritten words and faces differ considerably in their topographic form, both learning tasks share a common exemplar pooling component. In our first experiment, we find that typical observers' ability to learn facial identities and handwriting styles from exposure to multiple exemplars correlates closely. In our second experiment, we show that observers with Autism Spectrum Disorder (ASD) are impaired at both learning tasks. Our findings suggest that similar exemplar pooling processes are recruited when learning facial identities and handwriting styles. Models of exemplar pooling originally developed to explain face learning, may therefore offer valuable insights into exemplar pooling across a range of domains, extending beyond faces. Aberrant exemplar pooling, possibly resulting from structural differences in the inferior longitudinal fasciculus, may underlie difficulties recognising familiar faces often experienced by individuals with ASD, and leave observers overly reliant on local details present in particular exemplars. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. Spatial distribution of citizen science casuistic observations for different taxonomic groups.

    PubMed

    Tiago, Patrícia; Ceia-Hasse, Ana; Marques, Tiago A; Capinha, César; Pereira, Henrique M

    2017-10-16

    Opportunistic citizen science databases are becoming an important way of gathering information on species distributions. These data are temporally and spatially dispersed and could have limitations regarding biases in the distribution of the observations in space and/or time. In this work, we test the influence of landscape variables in the distribution of citizen science observations for eight taxonomic groups. We use data collected through a Portuguese citizen science database (biodiversity4all.org). We use a zero-inflated negative binomial regression to model the distribution of observations as a function of a set of variables representing the landscape features plausibly influencing the spatial distribution of the records. Results suggest that the density of paths is the most important variable, having a statistically significant positive relationship with number of observations for seven of the eight taxa considered. Wetland coverage was also identified as having a significant, positive relationship, for birds, amphibians and reptiles, and mammals. Our results highlight that the distribution of species observations, in citizen science projects, is spatially biased. Higher frequency of observations is driven largely by accessibility and by the presence of water bodies. We conclude that efforts are required to increase the spatial evenness of sampling effort from volunteers.

  3. 32 CFR 169a.17 - Solicitation considerations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Solicitation considerations. 169a.17 Section 169a.17 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM PROCEDURES Procedures § 169a.17 Solicitation considerations. (a) Every effort...

  4. 32 CFR 169a.17 - Solicitation considerations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Solicitation considerations. 169a.17 Section 169a.17 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM PROCEDURES Procedures § 169a.17 Solicitation considerations. (a) Every effort...

  5. 32 CFR 169a.17 - Solicitation considerations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Solicitation considerations. 169a.17 Section 169a.17 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM PROCEDURES Procedures § 169a.17 Solicitation considerations. (a) Every effort...

  6. 49 CFR 216.23 - Consideration of recommendation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Consideration of recommendation. 216.23 Section..., LOCOMOTIVE AND EQUIPMENT Emergency Order-Track § 216.23 Consideration of recommendation. Upon receipt of a... recommendation to the Administrator concerning the issuance of an Emergency order removing the affected track...

  7. 49 CFR 216.23 - Consideration of recommendation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Consideration of recommendation. 216.23 Section..., LOCOMOTIVE AND EQUIPMENT Emergency Order-Track § 216.23 Consideration of recommendation. Upon receipt of a... recommendation to the Administrator concerning the issuance of an Emergency order removing the affected track...

  8. 12 CFR 911.5 - Consideration of requests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Consideration of requests. 911.5 Section 911.5 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOUSING FINANCE BOARD ORGANIZATION AND OPERATIONS AVAILABILITY OF UNPUBLISHED INFORMATION § 911.5 Consideration of requests. (a) Discretion. Each...

  9. 12 CFR 911.5 - Consideration of requests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 8 2013-01-01 2013-01-01 false Consideration of requests. 911.5 Section 911.5 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOUSING FINANCE BOARD ORGANIZATION AND OPERATIONS AVAILABILITY OF UNPUBLISHED INFORMATION § 911.5 Consideration of requests. (a) Discretion. Each...

  10. 12 CFR 911.5 - Consideration of requests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Consideration of requests. 911.5 Section 911.5 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOUSING FINANCE BOARD ORGANIZATION AND OPERATIONS AVAILABILITY OF UNPUBLISHED INFORMATION § 911.5 Consideration of requests. (a) Discretion. Each...

  11. 12 CFR 911.5 - Consideration of requests.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 8 2012-01-01 2012-01-01 false Consideration of requests. 911.5 Section 911.5 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOUSING FINANCE BOARD ORGANIZATION AND OPERATIONS AVAILABILITY OF UNPUBLISHED INFORMATION § 911.5 Consideration of requests. (a) Discretion. Each...

  12. Bifurcations in the theory of current transfer to cathodes of DC discharges and observations of transitions between different modes

    NASA Astrophysics Data System (ADS)

    Bieniek, M. S.; Santos, D. F. N.; Almeida, P. G. C.; Benilov, M. S.

    2018-04-01

    General scenarios of transitions between different spot patterns on electrodes of DC gas discharges and their relation to bifurcations of steady-state solutions are analyzed. In the case of cathodes of arc discharges, it is shown that any transition between different modes of current transfer is related to a bifurcation of steady-state solutions. In particular, transitions between diffuse and spot modes on axially symmetric cathodes, frequently observed in the experiment, represent an indication of the presence of pitchfork or fold bifurcations of steady-state solutions. Experimental observations of transitions on cathodes of DC glow microdischarges are analyzed and those potentially related to bifurcations of steady-state solutions are identified. The relevant bifurcations are investigated numerically and the computed patterns are found to conform to those observed in the course of the corresponding transitions in the experiment.

  13. Observers' Agreement on Measurements in Fiberoptic Endoscopic Evaluation of Swallowing.

    PubMed

    Pilz, Walmari; Vanbelle, Sophie; Kremer, Bernd; van Hooren, Michel R; van Becelaere, Tine; Roodenburg, Nel; Baijens, Laura W J

    2016-04-01

    This study analyzed the effect that dysphagia etiology, different observers, and bolus consistency might have on the level of agreement for measurements in FEES images reached by independent versus consensus panel rating. Sixty patients were included and divided into two groups according to dysphagia etiology: neurological or head and neck oncological. All patients underwent standardized FEES examination using thin and thick liquid consistencies. Two observers scored the same exams, first independently and then in a consensus panel. Four ordinal FEES variables were analyzed. Statistical analysis was performed using a linear weighted kappa coefficient and Bayesian multilevel model. Intra- and interobserver agreement on FEES measurements ranged from 0.76 to 0.93 and from 0.61 to 0.88, respectively. Dysphagia etiology did not influence observers' agreement level. However, bolus consistency resulted in decreased interobserver agreement for all measured FEES variables during thin liquid swallows. When rating on the consensus panel, the observers deviated considerably from the scores they had previously given on the independent rating task. Observer agreement on measurements in FEES exams was influenced by bolus consistency, not by dysphagia etiology. Therefore, observer agreement on FEES measurements should be analyzed by taking bolus consistency into account, as it might affect the interpretation of the outcome. Identifying factors that might influence agreement levels could lead to better understanding of the rating process and assist in developing a more precise measurement scale that would ensure higher levels of observer agreement for measurements in FEES exams.

  14. Safe mobility for elderly drivers--considerations based on expert and self-assessment.

    PubMed

    Broberg, Thomas; Dukic Willstrand, Tania

    2014-05-01

    To further understand the needs of the growing population of elderly drivers and create solutions for safe mobility it is important to understand the driving scenarios and aspects in day to day traffic that may be of challenge for this group. More so, individual differences in how drivers perceive their own driving ability may have an effect on how individuals limit their mobility and/or increase their exposure to risk situations, with a potential negative effect on safety. In this study two sets of assessments have been used in order to identify scenarios and aspects needing consideration in creating safe mobility for elderly drivers; an expert assessment using on-road driving together with assessments through semi structured in-depth interviews. This combination also enables categorisation of the drivers, comparing their own perception of their driving performance with the expert assessment based on actual on-road driving. Four different categories of drivers were identified: adequate (positive), over, under and adequate (negative) estimators. A number of important aspects were identified in the study. Adapting speed to the situation and driving too fast, especially on straight roads in the city, is one aspect. Seeking the attention of other road users at intersections and roundabouts is another important consideration identified. Awareness of difficulties related to speed adaptation and attention was low amongst all the driver categories. However, a difference in attitude was seen in the categories with a more humble and acceptant attitude amongst the adequate and under estimator groups, as compared to the over estimators suggesting that the aspect of attitudes is another important factor for consideration. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. 48 CFR 970.1100-2 - Additional considerations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Additional considerations. 970.1100-2 Section 970.1100-2 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY... considerations. (a) While it is not feasible to set forth standard language which would apply to every contract...

  16. 46 CFR 177.340 - Alternate design considerations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Alternate design considerations. 177.340 Section 177.340... TONS) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.340 Alternate design considerations. When the structure of vessel is of novel design, unusual form, or special materials, which cannot be reviewed or...

  17. 48 CFR 970.1100-2 - Additional considerations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Additional considerations. 970.1100-2 Section 970.1100-2 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY... considerations. (a) While it is not feasible to set forth standard language which would apply to every contract...

  18. 48 CFR 970.1100-2 - Additional considerations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Additional considerations. 970.1100-2 Section 970.1100-2 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY... considerations. (a) While it is not feasible to set forth standard language which would apply to every contract...

  19. 48 CFR 970.1100-2 - Additional considerations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Additional considerations. 970.1100-2 Section 970.1100-2 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY... considerations. (a) While it is not feasible to set forth standard language which would apply to every contract...

  20. 48 CFR 970.1100-2 - Additional considerations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Additional considerations. 970.1100-2 Section 970.1100-2 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY... considerations. (a) While it is not feasible to set forth standard language which would apply to every contract...

  1. 47 CFR 3.21 - Order of consideration.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Order of consideration. 3.21 Section 3.21 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL AUTHORIZATION AND ADMINISTRATION OF ACCOUNTING AUTHORITIES IN MARITIME AND MARITIME MOBILE-SATELLITE RADIO SERVICES Application Procedures § 3.21 Order of consideration. (a) Accounting Authority...

  2. 47 CFR 3.21 - Order of consideration.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Order of consideration. 3.21 Section 3.21 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL AUTHORIZATION AND ADMINISTRATION OF ACCOUNTING AUTHORITIES IN MARITIME AND MARITIME MOBILE-SATELLITE RADIO SERVICES Application Procedures § 3.21 Order of consideration. (a) Accounting Authority...

  3. 47 CFR 3.21 - Order of consideration.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Order of consideration. 3.21 Section 3.21 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL AUTHORIZATION AND ADMINISTRATION OF ACCOUNTING AUTHORITIES IN MARITIME AND MARITIME MOBILE-SATELLITE RADIO SERVICES Application Procedures § 3.21 Order of consideration. (a) Accounting Authority...

  4. 47 CFR 3.21 - Order of consideration.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Order of consideration. 3.21 Section 3.21 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL AUTHORIZATION AND ADMINISTRATION OF ACCOUNTING AUTHORITIES IN MARITIME AND MARITIME MOBILE-SATELLITE RADIO SERVICES Application Procedures § 3.21 Order of consideration. (a) Accounting Authority...

  5. 20 CFR 322.4 - Consideration of evidence.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Consideration of evidence. 322.4 Section 322.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.4 Consideration of evidence. (a) Initial proof. A claimant's certification that he or she...

  6. 20 CFR 322.4 - Consideration of evidence.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Consideration of evidence. 322.4 Section 322.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT REMUNERATION § 322.4 Consideration of evidence. (a) Initial proof. A claimant's certification that he or she...

  7. Lyme Disease: Emergency Department Considerations.

    PubMed

    Applegren, Nathan D; Kraus, Chadd K

    2017-06-01

    Lyme disease (LD) is the most common vector-borne illness in North America. Reported cases of LD have increased from approximately 10,000 cases annually in 1991 to >25,000 cases in 2014. Greater recognition, enhanced surveillance, and public education have contributed to the increased prevalence, as have geographic expansion and the number of infected ticks. Cases are reported primarily in the Northeastern United States, Wisconsin, and Minnesota, with children having the highest incidence of LD among all age groups. The increased incidence and prevalence of LD in the United States makes it increasingly more common for patients to present to the emergency department (ED) for tick bites and LD-related chief complaints, such as the characteristic erythema migrans skin manifestation. We sought to review the etiology of LD, describe its clinical presentations and sequela, and provide a practical classification and approach to ED management of patients with LD-related presentations. In this review, ED considerations for LD are presented and clinical presentations and management of the disease at different stages is discussed. Delayed sequelae that have significant morbidity, including Lyme carditis and Lyme neuroborreliosis, are discussed. Diagnostic tests and management are described in detail. The increasing prevalence and growing geographic reach of Lyme disease makes it critically important for emergency physicians to consider the diagnosis in patients presenting with symptoms suggestive of LD and to initiate appropriate treatment to minimize the potential of delayed sequelae. Special consideration should be made for the epidemiology of LD and a high clinical suspicion should be present for patients in endemic areas or with known exposures to ticks. Emergency physicians can play a critical role in the recognition, diagnosis, and treatment of LD. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Consideration of climate change on environmental impact assessment in Spain

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Enríquez-de-Salamanca, Álvaro, E-mail: aenriquez@draba.org; Martín-Aranda, Rosa M., E-mail: rmartin@ccia.uned.es; Díaz-Sierra, Rubén, E-mail: sierra@dfmf.uned.es

    Most of the projects subject to environmental impact assessment (EIA) are closely related to climate change, as they contribute to or are affected by it. The growing certainty about climate change and its impacts makes its consideration an essential part of the EIA process, as well as in strategic environmental assessment (SEA). This paper examines how climate change (CC) has been taken into account in EIA in Spain through the analysis of 1713 environmental records of decision (RODs) of projects submitted for EIA. In 2013 Spain approved one of the most advanced laws in terms of CC consideration in environmentalmore » assessment, although it had not yet accumulated extensive practice on the issue. This contrasts with the situation of countries like Canada or the USA, which have a significant body of experience without specific legal requirements. Only 14% of the RODs analysed included references to CC, and in more than half of the cases it was a mere citation. Thermal power plants, which are subject to specific GHG regulations, show the highest consideration, while transport infrastructures, which are important contributors to CC, show a very low consideration. Almost all the references are related to their contribution to CC, while consideration of the effects of CC is minimal. The increasingly common incorporation of CC into SEA, should not imply its exclusion from EIA, because both processes have different aims and uses. Including the obligation to consider CC in the EIA regulations is highly desirable, but probably not enough without other measures, such as practical guidance, training and motivational programmes for practitioners and evaluators. But even these actions cannot ensure effective and adequate assessments of CC. Probably more resources should be spent on creating greater awareness in all the agents involved in EIA. - Highlights: • We analyse how the climate change is considered in EIA in Spain. • Few projects seriously assess climate change.

  9. Pronounced differences between observed and CMIP5-simulated multidecadal climate variability in the twentieth century

    NASA Astrophysics Data System (ADS)

    Kravtsov, Sergey

    2017-06-01

    Identification and dynamical attribution of multidecadal climate undulations to either variations in external forcings or to internal sources is one of the most important topics of modern climate science, especially in conjunction with the issue of human-induced global warming. Here we utilize ensembles of twentieth century climate simulations to isolate the forced signal and residual internal variability in a network of observed and modeled climate indices. The observed internal variability so estimated exhibits a pronounced multidecadal mode with a distinctive spatiotemporal signature, which is altogether absent in model simulations. This single mode explains a major fraction of model-data differences over the entire climate index network considered; it may reflect either biases in the models' forced response or models' lack of requisite internal dynamics, or a combination of both.Plain Language SummaryGlobal and regional warming trends over the course of the twentieth century have been nonuniform, with decadal and longer periods of faster or slower warming, or even cooling. Here we show that state-of-the-art global models used to predict climate fail to adequately reproduce such multidecadal climate variations. In particular, the models underestimate the magnitude of the <span class="hlt">observed</span> variability and misrepresent its spatial pattern. Therefore, our ability to interpret the <span class="hlt">observed</span> climate change using these models is limited.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23064177','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23064177"><span><span class="hlt">Consideration</span> of species <span class="hlt">differences</span> in developing novel molecules as cognition enhancers.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Young, Jared W; Jentsch, J David; Bussey, Timothy J; Wallace, Tanya L; Hutcheson, Daniel M</p> <p>2013-11-01</p> <p>The NIH-funded CNTRICS initiative has coordinated efforts to promote the vertical translation of novel procognitive molecules from testing in mice, rats and non-human primates, to clinical efficacy in patients with schizophrenia. CNTRICS highlighted improving construct validation of tasks across species to increase the likelihood that the translation of a candidate molecule to humans will be successful. Other aspects of cross-species behaviors remain important however. This review describes cognitive tasks utilized across species, providing examples of <span class="hlt">differences</span> and similarities of innate behavior between species, as well as convergent construct and predictive validity. Tests of attention, olfactory discrimination, reversal learning, and paired associate learning are discussed. Moreover, information on the practical implication of species <span class="hlt">differences</span> in drug development research is also provided. The issues covered here will aid in task development and utilization across species as well as reinforcing the positive role preclinical research can have in developing procognitive treatments for psychiatric disorders. Copyright © 2012 Elsevier Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2008OptCo.281.1823L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2008OptCo.281.1823L"><span>Phase matching <span class="hlt">considerations</span> in second harmonic generation from tissues: Effects on emission directionality, conversion efficiency and <span class="hlt">observed</span> morphology</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>LaComb, Ronald; Nadiarnykh, Oleg; Townsend, Sallie S.; Campagnola, Paul J.</p> <p>2008-04-01</p> <p>We present a heuristic treatment which relates SHG image intensities, signal directionality, and <span class="hlt">observed</span> morphology to the physical structure of collagen and cellulose fibrillar tissues. The SHG creation model is based upon relaxed phase matching conditions which account for dispersion, randomness, and axial momentum contributions from the media, and includes a mathematical treatment which relates SHG conversion efficiency to fibril diameter and packing through the inclusion of potential intensity amplification resultant from quasi-phase matching (QPM). A direct consequence of this theory is that SHG in biological tissues is not strictly a coherent process, and that the forward directed SHG has a longer coherence length than the backward component, Through this treatment, we show that the emission directionality and also conversion efficiency do not arise solely from the fibril size but also depend on packing density and order of the inter-fibril structure. We demonstrate these principles in comparing the SHG response in normal and Osteogenesis Imperfecta (OI) skin. We show that the <span class="hlt">observed</span> directionality and decreased relative intensity in the diseased state is consistent with phase matching conditions arising from the decreased fibril size and more random assembly. We further use this theory to explain the <span class="hlt">differences</span> in morphology seen in forward and backward collected SHG in fibrillar tissues (e.g., collagenous and cellulosic). Specifically, we attribute segmented appearance to destructive interference between small fibrils separated by less than the coherence length. We suggest the approach based on relaxed phasematching conditions is general in predicting the SHG response in tissues and may be broadly applicable in interpreting the SHG contrast for diagnostic applications.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5532639','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5532639"><span>Bioethical <span class="hlt">Considerations</span> of Advancing the Application of Marine Biotechnology and Aquaculture</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Harrell, Reginal M.</p> <p>2017-01-01</p> <p>Normative ethical <span class="hlt">considerations</span> of growth of the marine biotechnology and aquaculture disciplines in biopharming, food production, and marine products commercialization from a bioethical perspective have been limited. This paucity of information begs the question of what constitutes a bioethical approach (i.e., respect for individuals or autonomy; beneficence, nonmaleficence, and justice) to marine biotechnology and aquaculture, and whether it is one that is appropriate for <span class="hlt">consideration</span>. Currently, thoughtful discussion on the bioethical implications of use, development, and commercialization of marine organisms or their products, as well as potential environmental effects, defaults to human biomedicine as a model. One must question the validity of using human bioethical principlism moral norms for appropriating a responsible marine biotechnology and aquaculture ethic. When considering potential impacts within these disciplines, deference must be given to <span class="hlt">differing</span> value systems in order to find common ground to advance knowledge and avoid emotive impasses that can hinder the science and its application. The import of bioethical <span class="hlt">considerations</span> when conducting research and/or production is discussed. This discussion is directed toward applying bioethical principles toward technology used for food, biomedical development (e.g., biopharming), or as model species for advancement of knowledge for human diseases. PMID:28672802</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28672802','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28672802"><span>Bioethical <span class="hlt">Considerations</span> of Advancing the Application of Marine Biotechnology and Aquaculture.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Harrell, Reginal M</p> <p>2017-06-24</p> <p>Normative ethical <span class="hlt">considerations</span> of growth of the marine biotechnology and aquaculture disciplines in biopharming, food production, and marine products commercialization from a bioethical perspective have been limited. This paucity of information begs the question of what constitutes a bioethical approach (i.e., respect for individuals or autonomy; beneficence, nonmaleficence, and justice) to marine biotechnology and aquaculture, and whether it is one that is appropriate for <span class="hlt">consideration</span>. Currently, thoughtful discussion on the bioethical implications of use, development, and commercialization of marine organisms or their products, as well as potential environmental effects, defaults to human biomedicine as a model. One must question the validity of using human bioethical principlism moral norms for appropriating a responsible marine biotechnology and aquaculture ethic. When considering potential impacts within these disciplines, deference must be given to <span class="hlt">differing</span> value systems in order to find common ground to advance knowledge and avoid emotive impasses that can hinder the science and its application. The import of bioethical <span class="hlt">considerations</span> when conducting research and/or production is discussed. This discussion is directed toward applying bioethical principles toward technology used for food, biomedical development (e.g., biopharming), or as model species for advancement of knowledge for human diseases.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2008AGUSMSA33A..05R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2008AGUSMSA33A..05R"><span>Hemispheric <span class="hlt">differences</span> in PMC altitudes <span class="hlt">observed</span> by the AIM satellite for the 2007/2008 seasons</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Russell, J. M.; Bailey, S. M.; Gordley, L. L.; Hervig, M. E.; Stevens, M. H.; Thomas, G. E.; Rong, P.</p> <p>2008-05-01</p> <p>The Aeronomy of Ice in the Mesosphere (AIM) mission was launched from Vandenberg Air Force Base in California at 1:26:03 PDT on April 25, 2007 becoming the first satellite mission dedicated to the study of noctilucent clouds. A Pegasus XL rocket launched the satellite into a near perfect 600 km sun synchronous circular orbit providing an ideal injection for conducting AIM science studies. This paper focuses on hemispheric <span class="hlt">differences</span> in polar mesospheric cloud (PMC) altitudes <span class="hlt">observed</span> by the Solar Occultation For Ice Experiment (SOFIE) for the 2007 northern hemisphere season and the 2007/2008 southern hemisphere season. Results show PMC peak altitude <span class="hlt">differences</span> of 1 km to 3 km depending on time in the season which is larger than previous ground-based and satellite results (~1 km). SOFIE data show that altitude <span class="hlt">differences</span> are dependent on time within the season and that the <span class="hlt">differences</span> are correlated with mesopause height. Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) temperature data measured from the TIMED satellite over the 2003 to 2007 period show that hemispheric <span class="hlt">differences</span> in the summer mesopause height were unusually large for part of the 2007 PMC season, consistent with the 3 km height <span class="hlt">difference</span> in PMCs during that time.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28315542','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28315542"><span>Biosimilars: <span class="hlt">Considerations</span> for Oncology Nurses
.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Vizgirda, Vida; Jacobs, Ira</p> <p>2017-04-01</p> <p>Biosimilars are developed to be highly similar to and treat the same conditions as licensed biologics. As they are approved and their use becomes more widespread, oncology nurses should be aware of their development and unique <span class="hlt">considerations</span>. This article reviews properties of biosimilars; their regulation and approval process; the ways in which their quality, safety, and efficacy are evaluated; their postmarketing safety monitoring; and their significance to oncology nurses and oncology nursing.
. A search of PubMed and regulatory agency websites was conducted for references related to the development and use of biosimilars in oncology. 
. Because biologics are large, structurally complex molecules, biosimilars cannot be considered generic equivalents to licensed biologic products. Consequently, regulatory approval for biosimilars is <span class="hlt">different</span> from approval for small-molecule generics. Oncology nurses are in a unique position to educate themselves, other clinicians, and patients and their families about biosimilars to ensure accurate understanding, as well as optimal and safe use, of biosimilars.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19920021860&hterms=marine+pollution&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Dmarine%2Bpollution','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19920021860&hterms=marine+pollution&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Dmarine%2Bpollution"><span>Lidar <span class="hlt">observation</span> of marine mixed layer</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Yamagishi, Susumu; Yamanouchi, Hiroshi; Tsuchiya, Masayuki</p> <p>1992-01-01</p> <p>Marine mixed layer is known to play an important role in the transportation of pollution exiting ship funnels. The application of a diffusion model is critically dependent upon a reliable estimate of a lid. However, the processes that form lids are not well understood, though <span class="hlt">considerable</span> progress toward marine boundary layer has been achieved. This report describes <span class="hlt">observations</span> of the marine mixed layer from the course Ise-wan to Nii-jima with the intention of gaining a better understanding of their structure by a shipboard lidar. These <span class="hlt">observations</span> were made in the summer of 1991. One interesting feature of the <span class="hlt">observations</span> was that the multiple layers of aerosols, which is rarely numerically modeled, was encountered. No attempt is yet made to present a systematic analysis of all the data collected. Instead we focus on <span class="hlt">observations</span> that seem to be directly relevant to the structure of the mixed layer.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol7/pdf/CFR-2010-title49-vol7-sec604-21.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol7/pdf/CFR-2010-title49-vol7-sec604-21.pdf"><span>49 CFR 604.21 - Special <span class="hlt">considerations</span> for advisory opinions.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... Desist Orders § 604.21 Special <span class="hlt">considerations</span> for advisory opinions. Based on new facts involving significant financial <span class="hlt">considerations</span>, the Chief Counsel may take appropriate enforcement action contrary to an... 49 Transportation 7 2010-10-01 2010-10-01 false Special <span class="hlt">considerations</span> for advisory opinions. 604...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018PMB....63i5014E','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018PMB....63i5014E"><span>Lesion detectability in 2D-mammography and digital breast tomosynthesis using <span class="hlt">different</span> targets and <span class="hlt">observers</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Elangovan, Premkumar; Mackenzie, Alistair; Dance, David R.; Young, Kenneth C.; Wells, Kevin</p> <p>2018-05-01</p> <p>This work investigates the detection performance of specialist and non-specialist <span class="hlt">observers</span> for <span class="hlt">different</span> targets in 2D-mammography and digital breast tomosynthesis (DBT) using the OPTIMAM virtual clinical trials (VCT) Toolbox and a 4-alternative forced choice (4AFC) assessment paradigm. Using 2D-mammography and DBT images of virtual breast phantoms, we compare the detection limits of simple uniform spherical targets and irregular solid masses. Target diameters of 4 mm and 6 mm have been chosen to represent target sizes close to the minimum detectable size found in breast screening, across a range of controlled contrast levels. The images were viewed by a set of specialist <span class="hlt">observers</span> (five medical physicists and six experienced clinical readers) and five non-specialists. Combined results from both <span class="hlt">observer</span> groups indicate that DBT has a significantly lower detectable threshold contrast than 2D-mammography for small masses (4 mm: 2.1% [DBT] versus 6.9% [2D]; 6 mm: 0.7% [DBT] versus 3.9% [2D]) and spheres (4 mm: 2.9% [DBT] versus 5.3% [2D]; 6 mm: 0.3% [DBT] versus 2.2% [2D]) (p  <  0.0001). Both <span class="hlt">observer</span> groups found spheres significantly easier to detect than irregular solid masses for both sizes and modalities (p  <  0.0001) (except 4 mm DBT). The detection performances of specialist and non-specialist <span class="hlt">observers</span> were generally found to be comparable, where each group marginally outperformed the other in particular detection tasks. Within the specialist group, the clinical readers performed better than the medical physicists with irregular masses (p  <  0.0001). The results indicate that using spherical targets in such studies may produce over-optimistic detection thresholds compared to more complex masses, and that the superiority of DBT for detecting masses over 2D-mammography has been quantified. The results also suggest specialist <span class="hlt">observers</span> may be supplemented by non-specialist <span class="hlt">observers</span> (with training) in some types of 4AFC studies.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16371571','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16371571"><span>Weight preoccupation as a function of <span class="hlt">observed</span> physical attractiveness: ethnic <span class="hlt">differences</span> among normal-weight adolescent females.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Colabianchi, Natalie; Ievers-Landis, Carolyn E; Borawski, Elaine A</p> <p>2006-09-01</p> <p>To examine the association between <span class="hlt">observer</span> ratings of physical attractiveness and weight preoccupation for female adolescents, and to explore any ethnic <span class="hlt">differences</span> between Caucasian, African-American, and Hispanic females. Normal-weight female adolescents who had participated in the National Longitudinal Study of Adolescent Health in-home Wave II survey were included (n = 4,324). Physical attractiveness ratings were made in vivo by interviewers. Using logistic regression models stratified by ethnicity, the associations between <span class="hlt">observer</span>-rated attractiveness and weight preoccupation were examined after controlling for demographics, measured body mass index (BMI) and psychosocial factors. Caucasian female adolescents perceived as being more attractive reported significantly greater weight preoccupation compared with those rated as being less attractive. <span class="hlt">Observed</span> attractiveness did not relate to weight preoccupation among African-American or Hispanic youth when controlling for other factors. For Caucasian female adolescents, being perceived by others as more attractive may be a risk factor for disordered eating.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018PhLRv..24..114B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018PhLRv..24..114B"><span>The <span class="hlt">observability</span> principle and beyond. Reply to comments on "Seeing mental states: An experimental strategy for measuring the <span class="hlt">observability</span> of other minds" by Cristina Becchio et al.</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Becchio, Cristina; Koul, Atesh; Ansuini, Caterina; Bertone, Cesare; Cavallo, Andrea</p> <p>2018-03-01</p> <p>Is it possible to directly perceive others' mental states? Mediating the debate between Direct Perception and Inferentialism proponents would require knowing "what counts as an inference and how to tell the <span class="hlt">difference</span> between inferential and non-inferential processing" [1]. However, few theorists have even attempted to answer the question of what counts as inference. The consequence, as noted by Spaulding [1], is that "given that neither Inferentialists nor DSP [Direct Social Perception, Ed.] proponents specify what they mean by inference, it is hard to tell what exactly each side is affirming and denying. Thus, the debate between Inferentialism and DSP is at an impasse". Similar <span class="hlt">considerations</span> apply to distinguishing between what is '<span class="hlt">observable</span>' versus 'unobservable' [2].</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li class="active"><span>17</span></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_17 --> <div id="page_18" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active"><span>18</span></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="341"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012PhDT.......334B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012PhDT.......334B"><span>A generalized approach to wheat yield forecasting using earth <span class="hlt">observations</span>: Data <span class="hlt">considerations</span>, application and relevance</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Becker-Reshef, Inbal</p> <p></p> <p>In recent years there has been a dramatic increase in the demand for timely, comprehensive global agricultural intelligence. The issue of food security has rapidly risen to the top of government agendas around the world as the recent lack of food access led to unprecedented food prices, hunger, poverty, and civil conflict. Timely information on global crop production is indispensable for combating the growing stress on the world's crop production, for stabilizing food prices, developing effective agricultural policies, and for coordinating responses to regional food shortages. Earth <span class="hlt">Observations</span> (EO) data offer a practical means for generating such information as they provide global, timely, cost-effective, and synoptic information on crop condition and distribution. Their utility for crop production forecasting has long been recognized and demonstrated across a wide range of scales and geographic regions. Nevertheless it is widely acknowledged that EO data could be better utilized within the operational monitoring systems and thus there is a critical need for research focused on developing practical robust methods for agricultural monitoring. Within this context this dissertation focused on advancing EO-based methods for crop yield forecasting and on demonstrating the potential relevance for adopting EO-based crop forecasts for providing timely reliable agricultural intelligence. This thesis made contributions to this field by developing and testing a robust EO-based method for wheat production forecasting at state to national scales using available and easily accessible data. The model was developed in Kansas (KS) using coarse resolution normalized <span class="hlt">difference</span> vegetation index (NDVI) time series data in conjunction with out-of-season wheat masks and was directly applied in Ukraine to assess its transferability. The model estimated yields within 7% in KS and 10% in Ukraine of final estimates 6 weeks prior to harvest. The relevance of adopting such methods to</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://pubs.er.usgs.gov/publication/70112911','USGSPUBS'); return false;" href="https://pubs.er.usgs.gov/publication/70112911"><span><span class="hlt">Considerations</span> for blending data from various sensors</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Bauer, Brian P.; Barringer, Anthony R.</p> <p>1980-01-01</p> <p>A project is being proposed at the EROS Data Center to blend the information from sensors aboard various satellites. The problems of, and <span class="hlt">considerations</span> for, blending data from several satellite-borne sensors are discussed. System descriptions of the sensors aboard the HCMM, TIROS-N, GOES-D, Landsat 3, Landsat D, Seasat, SPOT, Stereosat, and NOSS satellites, and the quantity, quality, image dimensions, and availability of these data are summaries to define attributes of a multi-sensor satellite data base. Unique configurations of equipment, storage, media, and specialized hardware to meet the data system requirement are described as well as archival media and improved sensors that will be on-line within the next 5 years. Definitions and rigor required for blending various sensor data are given. Problems of merging data from the same sensor (intrasensor comparison) and from <span class="hlt">different</span> sensors (intersensor comparison), the characteristics and advantages of cross-calibration of data, and integration of data into a product matrix field are addressed. Data processing <span class="hlt">considerations</span> as affected by formation, resolution, and problems of merging large data sets, and organization of data bases for blending data are presented. Examples utilizing GOES and Landsat data are presented to demonstrate techniques of data blending, and recommendations for future implementation of a set of standard scenes and their characteristics necessary for optimal data blending are discussed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017EPSC...11..641B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017EPSC...11..641B"><span>"Journal of Space Economics - theoretical and practical <span class="hlt">considerations</span>"</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Beldavs, VZ; Sommers, J.</p> <p>2017-09-01</p> <p>This paper will address theoretical and practical <span class="hlt">considerations</span> for the emerging field of space economics and propose an editorial policy for a journal of space economics to provide a forum for the discussion of space economics issues. It is anticipated that initially the Journal of Space Economics will operate from two <span class="hlt">different</span> nodes one offering a European perspective (University of Latvia) and the other a U.S. perspective (University of Wisconsin at Milwaukee). The first edition of the Journal of Space Economics will focus on issues likely to arise during the course of the International Lunar Decade 2020-2030.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title34-vol1/pdf/CFR-2010-title34-vol1-sec5-84.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title34-vol1/pdf/CFR-2010-title34-vol1-sec5-84.pdf"><span>34 CFR 5.84 - <span class="hlt">Consideration</span> on review.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-07-01</p> <p>... 34 Education 1 2010-07-01 2010-07-01 false <span class="hlt">Consideration</span> on review. 5.84 Section 5.84 Education Office of the Secretary, Department of Education AVAILABILITY OF INFORMATION TO THE PUBLIC PURSUANT TO PUB. L. 90-23 (Eff. until 7-14-10) Administrative Review § 5.84 <span class="hlt">Consideration</span> on review. Review shall...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title46-vol7/pdf/CFR-2014-title46-vol7-sec177-340.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title46-vol7/pdf/CFR-2014-title46-vol7-sec177-340.pdf"><span>46 CFR 177.340 - Alternate design <span class="hlt">considerations</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-10-01</p> <p>... 46 Shipping 7 2014-10-01 2014-10-01 false Alternate design <span class="hlt">considerations</span>. 177.340 Section 177.340 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.340 Alternate design <span class="hlt">considerations</span>. When the structure of vessel is of novel design,...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title46-vol7/pdf/CFR-2012-title46-vol7-sec177-340.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title46-vol7/pdf/CFR-2012-title46-vol7-sec177-340.pdf"><span>46 CFR 177.340 - Alternate design <span class="hlt">considerations</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-10-01</p> <p>... 46 Shipping 7 2012-10-01 2012-10-01 false Alternate design <span class="hlt">considerations</span>. 177.340 Section 177.340 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.340 Alternate design <span class="hlt">considerations</span>. When the structure of vessel is of novel design,...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title46-vol7/pdf/CFR-2013-title46-vol7-sec177-340.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title46-vol7/pdf/CFR-2013-title46-vol7-sec177-340.pdf"><span>46 CFR 177.340 - Alternate design <span class="hlt">considerations</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-10-01</p> <p>... 46 Shipping 7 2013-10-01 2013-10-01 false Alternate design <span class="hlt">considerations</span>. 177.340 Section 177.340 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.340 Alternate design <span class="hlt">considerations</span>. When the structure of vessel is of novel design,...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21615009','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21615009"><span>One dozen <span class="hlt">considerations</span> when working with women in substance abuse groups.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bright, Charlotte Lyn; Osborne, Victoria A; Greif, Geoffrey L</p> <p>2011-01-01</p> <p>Women and men have <span class="hlt">different</span> histories, presentations, and behaviors in substance abuse groups. Twelve <span class="hlt">considerations</span> are offered for the beginning group leader when encountering women with substance abuse issues. These include understanding sexism, what brings women to treatment, and how women behave in group treatment. Implications for clinical practice with women in single-gender and mixed-gender groups are included.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29621037','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29621037"><span>"No-Go <span class="hlt">Considerations</span>" for In Situ Simulation Safety.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bajaj, Komal; Minors, Anjoinette; Walker, Katie; Meguerdichian, Michael; Patterson, Mary</p> <p>2018-06-01</p> <p>In situ simulation is the practice of simulation in the actual clinical environment and has demonstrated utility in the assessment of system processes, identification of latent safety threats, and improvement in teamwork and communication. Nonetheless, performing simulated events in a real patient care setting poses potential risks to patient and staff safety. One integral aspect of a comprehensive approach to ensure the safety of in situ simulation includes the identification and establishment of "no-go <span class="hlt">considerations</span>," that is, key decision-making <span class="hlt">considerations</span> under which in situ simulations should be canceled, postponed, moved to another area, or rescheduled. These <span class="hlt">considerations</span> should be modified and adjusted to specific clinical units. This article provides a framework of key essentials in developing no-go <span class="hlt">considerations</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28599544','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28599544"><span>Noise exposure-response relationships established from repeated binary <span class="hlt">observations</span>: Modeling approaches and applications.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Schäffer, Beat; Pieren, Reto; Mendolia, Franco; Basner, Mathias; Brink, Mark</p> <p>2017-05-01</p> <p>Noise exposure-response relationships are used to estimate the effects of noise on individuals or a population. Such relationships may be derived from independent or repeated binary <span class="hlt">observations</span>, and modeled by <span class="hlt">different</span> statistical methods. Depending on the method by which they were established, their application in population risk assessment or estimation of individual responses may yield <span class="hlt">different</span> results, i.e., predict "weaker" or "stronger" effects. As far as the present body of literature on noise effect studies is concerned, however, the underlying statistical methodology to establish exposure-response relationships has not always been paid sufficient attention. This paper gives an overview on two statistical approaches (subject-specific and population-averaged logistic regression analysis) to establish noise exposure-response relationships from repeated binary <span class="hlt">observations</span>, and their appropriate applications. The <span class="hlt">considerations</span> are illustrated with data from three noise effect studies, estimating also the magnitude of <span class="hlt">differences</span> in results when applying exposure-response relationships derived from the two statistical approaches. Depending on the underlying data set and the probability range of the binary variable it covers, the two approaches yield similar to very <span class="hlt">different</span> results. The adequate choice of a specific statistical approach and its application in subsequent studies, both depending on the research question, are therefore crucial.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title32-vol2/pdf/CFR-2012-title32-vol2-sec241-10.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title32-vol2/pdf/CFR-2012-title32-vol2-sec241-10.pdf"><span>32 CFR 241.10 - Small business <span class="hlt">consideration</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-07-01</p> <p>... 32 National Defense 2 2012-07-01 2012-07-01 false Small business <span class="hlt">consideration</span>. 241.10 Section 241...) § 241.10 Small business <span class="hlt">consideration</span>. The ASD(NII)/DoD CIO on behalf of the Secretary of Defense shall: (a) Ensure that, of the assignments made each year, at least 20 percent are small business concerns...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016AGUFMGC13H..03F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016AGUFMGC13H..03F"><span><span class="hlt">Observed</span> heavy precipitation increase confirms theory and early model</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Fischer, E. M.; Knutti, R.</p> <p>2016-12-01</p> <p>Environmental phenomena are often first <span class="hlt">observed</span>, and then explained or simulated quantitatively. The complexity and diversity of processes, the range of scales involved, and the lack of first principles to describe many processes make it challenging to predict conditions beyond the ones <span class="hlt">observed</span>. Here we use the intensification of heavy precipitation as a counterexample, where seemingly complex and potentially computationally intractable processes to first order manifest themselves in simple ways: the intensification of heavy precipitation is now emerging in the <span class="hlt">observed</span> record across many regions of the world, confirming both theory and a variety of model predictions made decades ago, before robust evidence arose from <span class="hlt">observations</span>. We here compare heavy precipitation changes over Europe and the contiguous United States across station series and gridded <span class="hlt">observations</span>, theoretical <span class="hlt">considerations</span> and multi-model ensembles of GCMs and RCMs. We demonstrate that the <span class="hlt">observed</span> heavy precipitation intensification aggregated over large areas agrees remarkably well with Clausius-Clapeyron scaling. The <span class="hlt">observed</span> changes in heavy precipitation are consistent yet somewhat larger than predicted by very coarse resolution GCMs in the 1980s and simulated by the newest generation of GCMs and RCMs. For instance the number of days with very heavy precipitation over Europe has increased by about 45% in <span class="hlt">observations</span> (years 1981-2013 compared to 1951-1980) and by about 25% in the model average in both GCMs and RCMs, although with substantial spread across models and locations. As the anthropogenic climate signal strengthens, there will be more opportunities to test climate predictions for other variables against <span class="hlt">observations</span> and across a hierarchy of <span class="hlt">different</span> models and theoretical concepts. *Fischer, E.M., and R. Knutti, 2016, <span class="hlt">Observed</span> heavy precipitation increase confirms theory and early models, Nature Climate Change, in press.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title32-vol6/pdf/CFR-2010-title32-vol6-sec1633-6.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title32-vol6/pdf/CFR-2010-title32-vol6-sec1633-6.pdf"><span>32 CFR 1633.6 - <span class="hlt">Consideration</span> of classes.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-07-01</p> <p>... 32 National Defense 6 2010-07-01 2010-07-01 false <span class="hlt">Consideration</span> of classes. 1633.6 Section 1633.6... CLASSIFICATION § 1633.6 <span class="hlt">Consideration</span> of classes. Claims of a registrant will be considered in inverse order of the listing of the classes below. When grounds are established to place a registrant in one or more of...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/2874968','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/2874968"><span>Use, indications and distribution in <span class="hlt">different</span> countries of the stimulant and hallucinogenic amphetamine derivatives under <span class="hlt">consideration</span> by WHO.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Keup, W</p> <p>1986-06-01</p> <p>Information is presented on legal manufacture, distribution, medical uses and in various countries of the stimulants and hallucinogens under <span class="hlt">consideration</span> by the World Health Organization (WHO). Data are reported from the Substance Abuse Warning System (SAWS) in the F.R.G. and other surveillance systems regarding illicit manufacture, trafficking and abuse of these compounds internationally. In addition, it is pointed out that assessment of the liability of these compounds for abuse must consider not only the substance itself but also its potential metabolic products. These data, collectively, indicate that the substances currently of most concern with respect to abuse are fenetylline and norpseudoephedrine.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28412511','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28412511"><span><span class="hlt">Difference</span> in neural response to social exclusion <span class="hlt">observation</span> and subsequent altruism between adolescents and adults.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tousignant, Béatrice; Eugène, Fanny; Sirois, Katia; Jackson, Philip L</p> <p>2017-04-13</p> <p>Empathy and prosocial behaviors toward peers promote successful social development and creation of significant long-term relationships, but surprisingly little is known about the maturation of these skills during the period of adolescence. As the majority of studies have used questionnaires or pain <span class="hlt">observation</span> paradigms, it remains unknown whether the empathic response of adolescents <span class="hlt">differs</span> from that of adults in a paradigm that is closer to everyday life. In the current study, fMRI was used to examine the neural correlates of social exclusion <span class="hlt">observation</span> and subsequent prosocial behavior in 20 adolescents (aged 12-17 years) and 20 adults (aged 22-30 years) while playing a ball-tossing game with what they believed to be real individuals. <span class="hlt">Observing</span> someone being excluded compared to <span class="hlt">observing</span> equal inclusion of all players elicited a significantly higher activation of the IFG (pars triangularis) in adults compared to adolescents. When given the opportunity to directly help the excluded player during the game, adolescents showed significantly less prosocial behavior than adults, which was underpinned by a significantly lower activity in the right temporoparietal junction, medial/dorsomedial prefrontal cortex and fusiform face area. These findings might indicate that adolescents have a lower propensity to take the victim's perspective and share his or her distress when witnessing social exclusion, which leads to a lower altruistic motivation to help. The factors that could generate what can be interpreted as a downward modulation of empathy during adolescence are discussed. Copyright © 2017 Elsevier Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26475721','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26475721"><span>The use of animal tissues alongside human tissue: Cultural and ethical <span class="hlt">considerations</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kaw, Anu; Jones, D Gareth; Zhang, Ming</p> <p>2016-01-01</p> <p>Teaching and research facilities often use cadaveric material alongside animal tissues, although there appear to be <span class="hlt">differences</span> in the way we handle, treat, and dispose of human cadaveric material compared to animal tissue. This study sought to analyze cultural and ethical <span class="hlt">considerations</span> and provides policy recommendations on the use of animal tissues alongside human tissue. The status of human and animal remains and the respect because of human and animal tissues were compared and analyzed from ethical, legal, and cultural perspectives. The use of animal organs and tissues is carried out within the context of understanding human anatomy and function. Consequently, the interests of human donors are to be pre-eminent in any policies that are enunciated, so that if any donors find the presence of animal remains unacceptable, the latter should not be employed. The major <span class="hlt">differences</span> appear to lie in <span class="hlt">differences</span> in our perceptions of their respective intrinsic and instrumental values. Animals are considered to have lesser intrinsic value and greater instrumental value than humans. These <span class="hlt">differences</span> stem from the role played by culture and ethical <span class="hlt">considerations</span>, and are manifested in the resulting legal frameworks. In light of this discussion, six policy recommendations are proposed, encompassing the nature of consent, respect for animal tissues as well as human remains, and appropriate separation of both sets of tissues in preparation and display. © 2015 Wiley Periodicals, Inc.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014AMTD....7.7053S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014AMTD....7.7053S"><span>Comparison of continuous in-situ CO2 <span class="hlt">observations</span> at Jungfraujoch using two <span class="hlt">different</span> measurement techniques</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Schibig, M. F.; Steinbacher, M.; Buchmann, B.; van der Laan-Luijkx, I. T.; van der Laan, S.; Ranjan, S.; Leuenberger, M. C.</p> <p>2014-07-01</p> <p>Since 2004, atmospheric carbon dioxide (CO2) is measured at the High Altitude Research Station Jungfraujoch by the division of Climate and Environmental Physics at the University of Bern (KUP) using a nondispersive infrared gas analyzer (NDIR) in combination with a paramagnetic O2 analyzer. In January 2010, CO2 measurements based on cavity ring down spectroscopy (CRDS) as part of the Swiss National Air Pollution Monitoring Network have been added by the Swiss Federal Laboratories for Materials Science and Technology (Empa). To ensure a smooth transition - a prerequisite when merging two datasets e.g. for trend determinations - the two measurement systems run in parallel for several years. Such a long-term intercomparison also allows identifying potential offsets between the two datasets and getting information about the compatibility of the two systems on <span class="hlt">different</span> time scales. A good agreement of the seasonality as well as for the short-term variations was <span class="hlt">observed</span> and to a lesser extent for trend calculations mainly due to the short common period. However, the comparison revealed some issues related to the stability of the calibration gases of the KUP system and their assigned CO2 mole fraction. It was possible to adapt an improved calibration strategy based on standard gas determinations, which lead to better agreement between the two data sets. By excluding periods with technical problems and bad calibration gas cylinders, the average hourly <span class="hlt">difference</span> (CRDS - NDIR) of the two systems is -0.03 ppm ± 0.25 ppm. Although the <span class="hlt">difference</span> of the two datasets is in line with the compatibility goal of ±0.1 ppm of the World Meteorological Organization (WMO), the standard deviation is still too high. A significant part of this uncertainty originates from the necessity to switch the KUP system frequently (every 12 min) for 6 min from ambient air to a working gas in order to correct short-term variations of the O2 measurement system. Allowing additionally for signal</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015AMT.....8...57S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015AMT.....8...57S"><span>Comparison of continuous in situ CO2 <span class="hlt">observations</span> at Jungfraujoch using two <span class="hlt">different</span> measurement techniques</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Schibig, M. F.; Steinbacher, M.; Buchmann, B.; van der Laan-Luijkx, I. T.; van der Laan, S.; Ranjan, S.; Leuenberger, M. C.</p> <p>2015-01-01</p> <p>Since 2004, atmospheric carbon dioxide (CO2) is being measured at the High Altitude Research Station Jungfraujoch by the division of Climate and Environmental Physics at the University of Bern (KUP) using a nondispersive infrared gas analyzer (NDIR) in combination with a paramagnetic O2 analyzer. In January 2010, CO2 measurements based on cavity ring-down spectroscopy (CRDS) as part of the Swiss National Air Pollution Monitoring Network were added by the Swiss Federal Laboratories for Materials Science and Technology (Empa). To ensure a smooth transition - a prerequisite when merging two data sets, e.g., for trend determinations - the two measurement systems run in parallel for several years. Such a long-term intercomparison also allows the identification of potential offsets between the two data sets and the collection of information about the compatibility of the two systems on <span class="hlt">different</span> time scales. A good agreement of the seasonality, short-term variations and, to a lesser extent mainly due to the short common period, trend calculations is <span class="hlt">observed</span>. However, the comparison reveals some issues related to the stability of the calibration gases of the KUP system and their assigned CO2 mole fraction. It is possible to adapt an improved calibration strategy based on standard gas determinations, which leads to better agreement between the two data sets. By excluding periods with technical problems and bad calibration gas cylinders, the average hourly <span class="hlt">difference</span> (CRDS - NDIR) of the two systems is -0.03 ppm ± 0.25 ppm. Although the <span class="hlt">difference</span> of the two data sets is in line with the compatibility goal of ±0.1 ppm of the World Meteorological Organization (WMO), the standard deviation is still too high. A significant part of this uncertainty originates from the necessity to switch the KUP system frequently (every 12 min) for 6 min from ambient air to a working gas in order to correct short-term variations of the O2 measurement system. Allowing additional time for</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2002iaf..confE.270M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2002iaf..confE.270M"><span>Space Tourism: Orbital Debris <span class="hlt">Considerations</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Mahmoudian, N.; Shajiee, S.; Moghani, T.; Bahrami, M.</p> <p>2002-01-01</p> <p>Space activities after a phase of research and development, political competition and national prestige have entered an era of real commercialization. Remote sensing, earth <span class="hlt">observation</span>, and communication are among the areas in which this growing industry is facing competition and declining government money. A project like International Space Station, which draws from public money, has not only opened a window of real multinational cooperation, but also changed space travel from a mere fantasy into a real world activity. Besides research activities for sending man to moon and Mars and other outer planets, space travel has attracted a <span class="hlt">considerable</span> attention in recent years in the form of space tourism. Four countries from space fairing nations are actively involved in the development of space tourism. Even, nations which are either in early stages of space technology development or just beginning their space activities, have high ambitions in this area. This is worth noting considering their limited resources. At present, trips to space are available, but limited and expensive. To move beyond this point to generally available trips to orbit and week long stays in LEO, in orbital hotels, some of the required basic transportations, living requirements, and technological developments required for long stay in orbit are already underway. For tourism to develop to a real everyday business, not only the price has to come down to meaningful levels, but also safety <span class="hlt">considerations</span> should be fully developed to attract travelers' trust. A serious hazard to space activities in general and space tourism in particular is space debris in earth orbit. Orbiting debris are man-made objects left over by space operations, hazardous to space missions. Since the higher density of debris population occurs in low earth orbit, which is also the same orbit of interest to space tourism, a careful attention should be paid to the effect of debris on tourism activities. In this study, after a</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3514646','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3514646"><span>Stereotypes of Age <span class="hlt">Differences</span> in Personality Traits: Universal and Accurate?</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Chan, Wayne; McCrae, Robert R.; De Fruyt, Filip; Jussim, Lee; Löckenhoff, Corinna E.; De Bolle, Marleen; Costa, Paul T.; Sutin, Angelina R.; Realo, Anu; Allik, Jüri; Nakazato, Katsuharu; Shimonaka, Yoshiko; Hřebíčková, Martina; Kourilova, Sylvie; Yik, Michelle; Ficková, Emília; Brunner-Sciarra, Marina; de Figueora, Nora Leibovich; Schmidt, Vanina; Ahn, Chang-kyu; Ahn, Hyun-nie; Aguilar-Vafaie, Maria E.; Siuta, Jerzy; Szmigielska, Barbara; Cain, Thomas R.; Crawford, Jarret T.; Mastor, Khairul Anwar; Rolland, Jean-Pierre; Nansubuga, Florence; Miramontez, Daniel R.; Benet-Martínez, Veronica; Rossier, Jérôme; Bratko, Denis; Halberstadt, Jamin; Yamaguchi, Mami; Knežević, Goran; Martin, Thomas A.; Gheorghiu, Mirona; Smith, Peter B.; Barbaranelli, Claduio; Wang, Lei; Shakespeare-Finch, Jane; Lima, Margarida P.; Klinkosz, Waldemar; Sekowski, Andrzej; Alcalay, Lidia; Simonetti, Franco; Avdeyeva, Tatyana V.; Pramila, V. S.; Terracciano, Antonio</p> <p>2012-01-01</p> <p>Age trajectories for personality traits are known to be similar across cultures. To address whether stereotypes of age groups reflect these age-related changes in personality, we asked participants in 26 countries (N = 3,323) to rate typical adolescents, adults, and old persons in their own country. Raters across nations tended to share similar beliefs about <span class="hlt">different</span> age groups; adolescents were seen as impulsive, rebellious, undisciplined, preferring excitement and novelty, whereas old people were consistently considered lower on impulsivity, activity, antagonism, and Openness. These consensual age group stereotypes correlated strongly with published age <span class="hlt">differences</span> on the five major dimensions of personality and most of 30 specific traits, using as criteria of accuracy both self-reports and <span class="hlt">observer</span> ratings, <span class="hlt">different</span> survey methodologies, and data from up to 50 nations. However, personal stereotypes were <span class="hlt">considerably</span> less accurate, and consensual stereotypes tended to exaggerate <span class="hlt">differences</span> across age groups. PMID:23088227</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active"><span>18</span></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_18 --> <div id="page_19" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="361"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AGUFM.A31O..08T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AGUFM.A31O..08T"><span>The utility of satellite <span class="hlt">observations</span> for constraining fine-scale and transient methane sources</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Turner, A. J.; Jacob, D.; Benmergui, J. S.; Brandman, J.; White, L.; Randles, C. A.</p> <p>2017-12-01</p> <p>Resolving <span class="hlt">differences</span> between top-down and bottom-up emissions of methane from the oil and gas industry is difficult due, in part, to their fine-scale and often transient nature. There is <span class="hlt">considerable</span> interest in using atmospheric <span class="hlt">observations</span> to detect these sources. Satellite-based instruments are an attractive tool for this purpose and, more generally, for quantifying methane emissions on fine scales. A number of instruments are planned for launch in the coming years from both low earth and geostationary orbit, but the extent to which they can provide fine-scale information on sources has yet to be explored. Here we present an <span class="hlt">observation</span> system simulation experiment (OSSE) exploring the tradeoffs between pixel resolution, measurement frequency, and instrument precision on the fine-scale information content of a space-borne instrument measuring methane. We use the WRF-STILT Lagrangian transport model to generate more than 200,000 column footprints at 1.3×1.3 km2 spatial resolution and hourly temporal resolution over the Barnett Shale in Texas. We sub-sample these footprints to match the <span class="hlt">observing</span> characteristics of the planned TROPOMI and GeoCARB instruments as well as <span class="hlt">different</span> hypothetical <span class="hlt">observing</span> configurations. The information content of the various <span class="hlt">observing</span> systems is evaluated using the Fisher information matrix and its singular values. We draw conclusions on the capabilities of the planned satellite instruments and how these capabilities could be improved for fine-scale source detection.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014AGUFMSA31B4097M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014AGUFMSA31B4097M"><span>Comparison with the horizontal phase velocity distribution of gravity waves <span class="hlt">observed</span> airglow imaging data of <span class="hlt">different</span> sampling periods</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Matsuda, T. S.; Nakamura, T.; Ejiri, M. K.; Tsutsumi, M.; Shiokawa, K.</p> <p>2014-12-01</p> <p>Atmospheric gravity waves (AGWs), which are generated in the lower atmosphere, transport significant amount of energy and momentum into the mesosphere and lower thermosphere. Among many parameters to characterize AGWs, horizontal phase velocity is very important to discuss the vertical propagation. Airglow imaging is a useful technique for investigating the horizontal structures of AGWs around mesopause. There are many airglow imagers operated all over the world, and a large amount of data which could improve our understanding of AGWs propagation direction and source distribution in the MLT region. We have developed a new statistical analysis method for obtaining the power spectrum in the horizontal phase velocity domain (phase velocity spectrum), from airglow image data, so as to deal with huge amounts of imaging data obtained on <span class="hlt">different</span> years and at various <span class="hlt">observation</span> sites, without bias caused by <span class="hlt">different</span> event extraction criteria for the <span class="hlt">observer</span>. From a series of images projected onto the geographic coordinates, 3-D Fourier transform is applied and 3-D power spectrum in horizontal wavenumber and frequency domain is obtained. Then, it is converted into phase velocity and frequency domain. Finally, the spectrum is integrated along the frequency for the range of interest and 2-D spectrum in horizontal phase velocity is calculated. This method was applied to the data obtained at Syowa Station (69ºS, 40ºE), Antarctica, in 2011 and compared with a conventional event analysis in which the phase fronts were traced manually in order to estimate horizontal propagation characteristics. This comparison shows that our new method is adequate to deriving the horizontal phase velocity characteristics of AGWs <span class="hlt">observed</span> by airglow imaging technique. Airglow imaging <span class="hlt">observation</span> has been operated with various sampling intervals. We also presents how the images with <span class="hlt">different</span> sample interval should be treated.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title32-vol4/pdf/CFR-2010-title32-vol4-sec643-83.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title32-vol4/pdf/CFR-2010-title32-vol4-sec643-83.pdf"><span>32 CFR 643.83 - <span class="hlt">Consideration</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-07-01</p> <p>... Easements § 643.83 <span class="hlt">Consideration</span>. Although the statutes authorizing grants of rights of way or easements do... an exception to this rule, grants to States, counties, municipalities, or political subdivisions...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3729910','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3729910"><span>Quantitative and qualitative <span class="hlt">differences</span> in use and trends of hematopoietic stem cell transplantation: a Global <span class="hlt">Observational</span> Study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Gratwohl, Alois; Baldomero, Helen; Gratwohl, Michael; Aljurf, Mahmoud; Bouzas, Luis Fernando; Horowitz, Mary; Kodera, Yoshihisa; Lipton, Jeff; Iida, Minako; Pasquini, Marcelo C.; Passweg, Jakob; Szer, Jeff; Madrigal, Alejandro; Frauendorfer, Karl; Niederwieser, Dietger</p> <p>2013-01-01</p> <p>Fifty-five years after publication of the first hematopoietic stem cell transplantation this technique has become an accepted treatment option for defined hematologic and non-hematologic disorders. There is <span class="hlt">considerable</span> interest in understanding <span class="hlt">differences</span> in its use and trends on a global level and the macro-economic factors associated with these <span class="hlt">differences</span>. Data on the numbers of hematopoietic stem cell transplants performed in the 3-year period 2006–2008 were obtained from Worldwide Network for Blood and Marrow Transplantation member registries and from transplant centers in countries without registries. Population and macro-economic data were collected from the World Bank and from the International Monetary Fund. Transplant rates were analyzed by indication, donor type, country, and World Health Organization regional offices areas and related to selected health care indicators using single and multiple linear regression analyses. Data from a total of 146,808 patients were reported by 1,411 teams from 72 countries over five continents. The annual number of transplants increased worldwide with the highest relative increase in the Asia Pacific region. Transplant rates increased preferentially in high income countries (P=0.02), not in low or medium income countries. Allogeneic transplants increased for myelodysplasia, chronic lymphocytic leukemia, acute leukemias, and non-malignant diseases but decreased for chronic myelogenous leukemia. Autologous transplants increased for autoimmune and lymphoproliferative diseases but decreased for leukemias and solid tumors. Transplant rates (P<0.01), donor type (P<0.01) aand disease indications (P<0.01) <span class="hlt">differed</span> significantly between countries and regions. Transplant rates were associated with Gross National Income/capita (P<0.01) but showed a wide variation of explanatory content by donor type, disease indication and World Health Organization region. Hematopoietic stem cell transplantation activity is increasing worldwide</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/10169530','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/10169530"><span><span class="hlt">Considerations</span> in pharmaceutical conversion: focus on antihistamines.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Garbus, S B; Moulton, B W; Meltzer, E O; Reich, P R; Weinreb, L F; Friedman, J A; Orland, B I</p> <p>1997-04-01</p> <p>The practice of pharmaceutical conversion, which encompasses three types of drug interchange (generic, brand, and therapeutic substitution), is increasing in managed care settings. Pharmaceutical conversion has numerous implications for managed care organizations, their healthcare providers, and their customers. Although drug cost may be a driving <span class="hlt">consideration</span> in pharmaceutical conversion, a number of other <span class="hlt">considerations</span> are of equal or greater importance in the decision-making process may affect the overall cost of patient care. Among these <span class="hlt">considerations</span> are clinical, psychosocial, and safety issues; patient adherence; patient satisfaction; and legal implications of pharmaceutical conversion. Patient-centered care must always remain central to decisions about pharmaceutical conversion. This article discusses the issues related to, and implications of, pharmaceutical conversion utilizing the antihistamines class of drugs as the case situation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5626440','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5626440"><span>Embedding clinical interventions into <span class="hlt">observational</span> studies</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Newman, Anne B.; Avilés-Santa, M. Larissa; Anderson, Garnet; Heiss, Gerardo; Howard, Wm. James; Krucoff, Mitchell; Kuller, Lewis H.; Lewis, Cora E.; Robinson, Jennifer G.; Taylor, Herman; Treviño, Roberto P.; Weintraub, William</p> <p>2017-01-01</p> <p>Novel approaches to <span class="hlt">observational</span> studies and clinical trials could improve the cost-effectiveness and speed of translation of research. Hybrid designs that combine elements of clinical trials with <span class="hlt">observational</span> registries or cohort studies should be considered as part of a long-term strategy to transform clinical trials and epidemiology, adapting to the opportunities of big data and the challenges of constrained budgets. Important <span class="hlt">considerations</span> include study aims, timing, breadth and depth of the existing infrastructure that can be leveraged, participant burden, likely participation rate and available sample size in the cohort, required sample size for the trial, and investigator expertise. Community engagement and stakeholder (including study participants) support are essential for these efforts to succeed. PMID:26611435</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1995SPIE.2558...36S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1995SPIE.2558...36S"><span>Producibility <span class="hlt">consideration</span> for millimeter-wave transceivers</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Seashore, Charles R.</p> <p>1995-10-01</p> <p><span class="hlt">Considerable</span> progress has been made in the development and demonstration of millimeter wave MMIC technology up to frequencies approaching 100 GHz. The recently completed multiyear, ARPA-sponsored, MIMIC program provided a <span class="hlt">considerable</span> amount of funding and government-contractor team energy to advance the state-of-art with a number of important GaAs-based transceiver building blocks. Unfortuanely, producibility of millimeter wave MMIC transceiver modules has not been similarly addressed to provide a truly low cost, marketable product. This paper considers the module producibility problem and its various technological implications.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19850021225','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19850021225"><span>Dynamic <span class="hlt">Considerations</span> for Control of Closed Life Support Systems</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Babcock, P. S.; Auslander, D. M.; Spear, R. C.</p> <p>1985-01-01</p> <p>Reliability of closed life support systems depend on their ability to continue supplying the crew's needs during perturbations and equipment failures. The dynamic <span class="hlt">considerations</span> interact with the basic static design through the sizing of storages, the specification of excess capacities in processors, and the choice of system initial state. A very simple system flow model was used to examine the possibilities for system failures even when there is sufficient storage to buffer the immediate effects of the perturbation. Two control schemes are shown which have <span class="hlt">different</span> dynamic consequences in response to component failures.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5868281','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5868281"><span>Cancer in Transgender People: Evidence and Methodological <span class="hlt">Considerations</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Braun, Hayley; Nash, Rebecca; Tangpricha, Vin; Brockman, Janice; Ward, Kevin; Goodman, Michael</p> <p>2017-01-01</p> <p>Abstract Transgender people comprise a diverse group of individuals whose gender identity or expression <span class="hlt">differs</span> from that originally assigned to them at birth. Some, but not all, transgender people elect to undergo medical gender affirmation, which may include therapy with cross-sex hormones and/or surgical change of the genitalia and other sex characteristics. As cross-sex hormones administered for the purposes of gender affirmation may be delivered at high doses and over a period of decades, the carcinogenicity of hormonal therapy in transgender people is an area of <span class="hlt">considerable</span> concern. In addition, concerns about cancer risk in transgender patients have been linked to sexually transmitted infections, increased exposure to well-known risk factors such as smoking and alcohol use, and the lack of adequate access to screening. Several publications have identified cancer as an important priority in transgender health research and called for large-scale studies. The goals of this article are to summarize the evidence on factors that may differentially affect cancer risk in transgender people, assess the relevant cancer surveillance and epidemiologic data available to date, and offer an overview of possible methodological <span class="hlt">considerations</span> for future studies investigating cancer incidence and mortality in this population. PMID:28486701</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013SPIE.8756E..04T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013SPIE.8756E..04T"><span><span class="hlt">Considerations</span> for multiple hypothesis correlation on tactical platforms</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Thomas, Alan M.; Turpen, James E.</p> <p>2013-05-01</p> <p>Tactical platforms benefit greatly from the fusion of tracks from multiple sources in terms of increased situation awareness. As a necessary precursor to this track fusion, track-to-track association, or correlation, must first be performed. The related measurement-to-track fusion problem has been well studied with multiple hypothesis tracking and multiple frame assignment methods showing the most success. The track-to-track problem <span class="hlt">differs</span> from this one in that measurements themselves are not available but rather track state update reports from the measuring sensors. Multiple hypothesis, multiple frame correlation systems have previously been considered; however, their practical implementation under the constraints imposed by tactical platforms is daunting. The situation is further exacerbated by the inconvenient nature of reports from legacy sensor systems on bandwidth- limited communications networks. In this paper, <span class="hlt">consideration</span> is given to the special difficulties encountered when attempting the correlation of tracks from legacy sensors on tactical aircraft. Those difficulties include the following: covariance information from reporting sensors is frequently absent or incomplete; system latencies can create temporal uncertainty in data; and computational processing is severely limited by hardware and architecture. Moreover, <span class="hlt">consideration</span> is given to practical solutions for dealing with these problems in a multiple hypothesis correlator.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27322190','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27322190"><span>Research Methods in Healthcare Epidemiology and Antimicrobial Stewardship-<span class="hlt">Observational</span> Studies.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Snyder, Graham M; Young, Heather; Varman, Meera; Milstone, Aaron M; Harris, Anthony D; Munoz-Price, Silvia</p> <p>2016-10-01</p> <p><span class="hlt">Observational</span> studies compare outcomes among subjects with and without an exposure of interest, without intervention from study investigators. <span class="hlt">Observational</span> studies can be designed as a prospective or retrospective cohort study or as a case-control study. In healthcare epidemiology, these <span class="hlt">observational</span> studies often take advantage of existing healthcare databases, making them more cost-effective than clinical trials and allowing analyses of rare outcomes. This paper addresses the importance of selecting a well-defined study population, highlights key <span class="hlt">considerations</span> for study design, and offers potential solutions including biostatistical tools that are applicable to <span class="hlt">observational</span> study designs. Infect Control Hosp Epidemiol 2016;1-6.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22035493','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22035493"><span>Primary total hip replacement versus hip resurfacing - hospital <span class="hlt">considerations</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ward, William G; Carter, Christina J; Barone, Marisa; Jinnah, Riyaz</p> <p>2011-01-01</p> <p>Multiple factors regarding surgical procedures and patient selection affect hospital staffing needs as well as hospital revenues. In order to better understand the potential impact on hospitals that hip arthroplasty device selection (standard total hip arthroplasty vs. resurfacing) creates, a review of all primary hip arthroplasties performed at one institution was designed to identify factors that impacted hospital staffing needs and revenue generation. All primary hip arthroplasties undertaken over three fiscal years (2008 to 2010) were reviewed, utilizing only hospital business office data and medical records data that had been previously extracted prior for billing purposes. Analysis confirmed <span class="hlt">differing</span> demographics for two hip arthroplasty populations, with the resurfacing patients (compared to the conventional total hip arthroplasty population) consisting of younger patients (mean age, 50 vs. 61 years), who were more often male (75% vs. 45%), were more likely to have osteoarthritis as their primary diagnosis (83 vs. 67%) and were more often covered by managed care or commercial insurance (83 vs. 34%). They also had shorter hospital stays (mean length of stay, 2.3 vs. 4.1 days) and consequently provided a more favorable financial revenue stream to the hospital on a per patient basis. Several trends appeared during the study periods. There was a steady increase in all procedures in all groups except for the resurfacings, which decreased 26% in males and 53% in females between 2009 and 2010. <span class="hlt">Differences</span> were <span class="hlt">observed</span> in the demographics of patients presenting for resurfacing, compared to those presenting for conventional total hip arthroplasty. In addition to the revenue stream <span class="hlt">considerations</span>, institutions undertaking a resurfacing program must commit the resources and planning in order to rehabilitate these patients more expeditiously than is usually required with conventional hip arthroplasty patients.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28810062','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28810062"><span>The association between patient attitudes and values and the strength of <span class="hlt">consideration</span> for contralateral prophylactic mastectomy in a population-based sample of breast cancer patients.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hawley, Sarah T; Griffith, Kent A; Hamilton, Ann S; Ward, Kevin C; Morrow, Monica; Janz, Nancy K; Katz, Steven J; Jagsi, Reshma</p> <p>2017-12-01</p> <p>Little is known about how the individual decision styles and values of breast cancer patients at the time of treatment decision making are associated with the <span class="hlt">consideration</span> of <span class="hlt">different</span> treatment options and specifically with the <span class="hlt">consideration</span> of contralateral prophylactic mastectomy (CPM). Newly diagnosed patients with early-stage breast cancer who were treated in 2013-2014 were identified through the Surveillance, Epidemiology, and End Results registries of Los Angeles and Georgia and were surveyed approximately 7 months after surgery (n = 2578; response rate, 71%). The primary outcome was the <span class="hlt">consideration</span> of CPM (strong vs less strong). The association between patients' values and decision styles and strong <span class="hlt">consideration</span> was assessed with multivariate logistic regression. Approximately one-quarter of women (25%) reported strong/very strong <span class="hlt">consideration</span> of CPM, and another 29% considered it moderately/weakly. Decision styles, including a rational-intuitive approach to decision making, varied. The factors most valued by women at the time of treatment decision making were as follows: avoiding worry about recurrence (82%) and reducing the need for more surgery (73%). In a multivariate analysis, patients who preferred to make their own decisions, those who valued avoiding worry about recurrence, and those who valued avoiding radiation significantly more often strongly considered CPM (P < .05), whereas those who reported being more logical and those who valued keeping their breast did so less often. Many patients considered CPM, and the <span class="hlt">consideration</span> was associated with both decision styles and values. The variability in decision styles and values <span class="hlt">observed</span> in this study suggests that formally evaluating these characteristics at or before the initial treatment encounter could provide an opportunity for improving patient clinician discussions. Cancer 2017;123:4547-4555. © 2017 American Cancer Society. © 2017 American Cancer Society.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5731733','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5731733"><span>A <span class="hlt">different</span> view on the Necker cube—<span class="hlt">Differences</span> in multistable perception dynamics between Asperger and non-Asperger <span class="hlt">observers</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Wörner, Rike</p> <p>2017-01-01</p> <p>Background During <span class="hlt">observation</span> of the Necker cube perception becomes unstable and alternates repeatedly between a from-above-perspective (“fap”) and a from-below-perspective (“fbp”) interpretation. Both interpretations are physically equally plausible, however, <span class="hlt">observers</span> usually show an a priori top-down bias in favor of the fap interpretation. Patients with Autism spectrum disorder are known to show an altered pattern of perception with a focus on sensory details. In the present study we tested whether this altered perceptual processing affects their reversal dynamics and reduces the perceptual bias during Necker cube <span class="hlt">observation</span>. Methods 19 participants with Asperger syndrome and 16 healthy controls <span class="hlt">observed</span> a Necker cube stimulus continuously for 5 minutes and indicated perceptual reversals by key press. We compared reversal rates (number of reversals per minute) and the distributions of dwell times for the two interpretations between <span class="hlt">observer</span> groups. Results Asperger participants showed less perceptual reversal than controls. Six Asperger participants did not perceive any reversal at all, whereas all <span class="hlt">observers</span> from the control group perceived at least five reversals within the five minutes <span class="hlt">observation</span> time. Further, control participants showed the typical perceptual bias with significant longer median dwell times for the fap compared to the fbp interpretation. No such perceptual bias was found in the Asperger group. Discussion The perceptual system weights the incomplete and ambiguous sensory input with memorized concepts in order to construct stable and reliable percepts. In the case of the Necker cube stimulus, two perceptual interpretations are equally compatible with the sensory information and internal fluctuations may cause perceptual alternations between them—with a slightly larger probability value for the fap interpretation (perceptual bias). Smaller reversal rates in Asperger <span class="hlt">observers</span> may result from the dominance of bottom-up sensory input</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29244813','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29244813"><span>A <span class="hlt">different</span> view on the Necker cube-<span class="hlt">Differences</span> in multistable perception dynamics between Asperger and non-Asperger <span class="hlt">observers</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kornmeier, Jürgen; Wörner, Rike; Riedel, Andreas; Tebartz van Elst, Ludger</p> <p>2017-01-01</p> <p>During <span class="hlt">observation</span> of the Necker cube perception becomes unstable and alternates repeatedly between a from-above-perspective ("fap") and a from-below-perspective ("fbp") interpretation. Both interpretations are physically equally plausible, however, <span class="hlt">observers</span> usually show an a priori top-down bias in favor of the fap interpretation. Patients with Autism spectrum disorder are known to show an altered pattern of perception with a focus on sensory details. In the present study we tested whether this altered perceptual processing affects their reversal dynamics and reduces the perceptual bias during Necker cube <span class="hlt">observation</span>. 19 participants with Asperger syndrome and 16 healthy controls <span class="hlt">observed</span> a Necker cube stimulus continuously for 5 minutes and indicated perceptual reversals by key press. We compared reversal rates (number of reversals per minute) and the distributions of dwell times for the two interpretations between <span class="hlt">observer</span> groups. Asperger participants showed less perceptual reversal than controls. Six Asperger participants did not perceive any reversal at all, whereas all <span class="hlt">observers</span> from the control group perceived at least five reversals within the five minutes <span class="hlt">observation</span> time. Further, control participants showed the typical perceptual bias with significant longer median dwell times for the fap compared to the fbp interpretation. No such perceptual bias was found in the Asperger group. The perceptual system weights the incomplete and ambiguous sensory input with memorized concepts in order to construct stable and reliable percepts. In the case of the Necker cube stimulus, two perceptual interpretations are equally compatible with the sensory information and internal fluctuations may cause perceptual alternations between them-with a slightly larger probability value for the fap interpretation (perceptual bias). Smaller reversal rates in Asperger <span class="hlt">observers</span> may result from the dominance of bottom-up sensory input over endogenous top-down factors. The latter may</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27457637','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27457637"><span>Are There Clinical Implications of Racial <span class="hlt">Differences</span> in HbA1c? A <span class="hlt">Difference</span>, to Be a <span class="hlt">Difference</span>, Must Make a <span class="hlt">Difference</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Selvin, Elizabeth</p> <p>2016-08-01</p> <p>Studies that have compared HbA1c levels by race have consistently demonstrated higher HbA1c levels in African Americans than in whites. These racial <span class="hlt">differences</span> in HbA1c have not been explained by measured <span class="hlt">differences</span> in glycemia, sociodemographic factors, clinical factors, access to care, or quality of care. Recently, a number of nonglycemic factors and several genetic polymorphisms that operate through nonglycemic mechanisms have been associated with HbA1c Their distributions across racial groups and their impact on hemoglobin glycation need to be systematically explored. Thus, on the basis of evidence for racial <span class="hlt">differences</span> in HbA1c, current clinical guidelines from the American Diabetes Association state: "It is important to take…race/ethnicity…into <span class="hlt">consideration</span> when using the A1C to diagnose diabetes." However, it is not clear from the guidelines how this recommendation might be actualized. So, the critical question is not whether racial <span class="hlt">differences</span> in HbA1c exist between African Americans and whites; the important question is whether the <span class="hlt">observed</span> <span class="hlt">differences</span> in HbA1c level are clinically meaningful. Therefore, given the current controversy, we provide a Point-Counterpoint debate on this issue. In the preceding point narrative, Dr. Herman provides his argument that the failure to acknowledge that HbA1c might be a biased measure of average glycemia and an unwillingness to rigorously investigate this hypothesis will slow scientific progress and has the potential to do great harm. In the counterpoint narrative below, Dr. Selvin argues that there is no compelling evidence for racial <span class="hlt">differences</span> in the validity of HbA1c as a measure of hyperglycemia and that race is a poor surrogate for <span class="hlt">differences</span> in underlying causes of disease risk.-William T. CefaluEditor in Chief, Diabetes Care. © 2016 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25446969','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25446969"><span>Processing of action- but not stimulus-related prediction errors <span class="hlt">differs</span> between active and <span class="hlt">observational</span> feedback learning.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kobza, Stefan; Bellebaum, Christian</p> <p>2015-01-01</p> <p>Learning of stimulus-response-outcome associations is driven by outcome prediction errors (PEs). Previous studies have shown larger PE-dependent activity in the striatum for learning from own as compared to <span class="hlt">observed</span> actions and the following outcomes despite comparable learning rates. We hypothesised that this finding relates primarily to a stronger integration of action and outcome information in active learners. Using functional magnetic resonance imaging, we investigated brain activations related to action-dependent PEs, reflecting the deviation between action values and obtained outcomes, and action-independent PEs, reflecting the deviation between subjective values of response-preceding cues and obtained outcomes. To this end, 16 active and 15 <span class="hlt">observational</span> learners engaged in a probabilistic learning card-guessing paradigm. On each trial, active learners saw one out of five cues and pressed either a left or right response button to receive feedback (monetary win or loss). Each <span class="hlt">observational</span> learner <span class="hlt">observed</span> exactly those cues, responses and outcomes of one active learner. Learning performance was assessed in active test trials without feedback and did not <span class="hlt">differ</span> between groups. For both types of PEs, activations were found in the globus pallidus, putamen, cerebellum, and insula in active learners. However, only for action-dependent PEs, activations in these structures and the anterior cingulate were increased in active relative to <span class="hlt">observational</span> learners. Thus, PE-related activity in the reward system is not generally enhanced in active relative to <span class="hlt">observational</span> learning but only for action-dependent PEs. For the cerebellum, additional activations were found across groups for cue-related uncertainty, thereby emphasising the cerebellum's role in stimulus-outcome learning. Copyright © 2014 Elsevier Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/7326840','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/7326840"><span>Delayed echolalia in autism: some <span class="hlt">observations</span> on <span class="hlt">differences</span> within the term.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Dyer, C; Hadden, A J</p> <p>1981-01-01</p> <p>Attention has recently focused on the need to build up a corpus of case <span class="hlt">observations</span> relating to the function of delayed echolalia in various handicapping conditions but especially in early childhood autism. This present article offers six functional categories as an aid to clear reporting of <span class="hlt">observation</span> and, thus clarification of this little-understood facet of deviant language development.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016amos.confE..21P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016amos.confE..21P"><span>Mission Design and Simulation <span class="hlt">Considerations</span> for ADReS-A</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Peters, S.; Förstner, R.; Fiedler, H.</p> <p>2016-09-01</p> <p>Space debris in general has become a major problem for modern space activities. Guidelines to mitigate the threat have been recommended, better prediction models are developed and an advanced <span class="hlt">observation</span> of objects orbiting Earth is in progress. And still - without the implementation of active debris removal (ADR), the number of debris in space will exponentially increase. To support the ongoing research on ADR-missions, this paper presents the updated mission design of ADReS-A (Autonomous Debris Removal Satellite - #A) - one possible concept for the multiple active removal of large debris in Low Earth orbit, in this case especially of rocket bodies of the SL-8-type. ADReS-A as chaser satellite is supported by at least 5 de-orbit kits, allowing for the same number of targets to be removed. While ADReS-A is conceived for handling of the target, the kit's task is the controlled re-entry of the designated rocket body. The presented mission design forms the basis for the simulation environment in progress. The simulation shall serve as testbed to test multiple scenarios in terms of approach and abort optimization or <span class="hlt">different</span> tumbling modes of the target. The ultimate goal is the test of autonomous behaviors of the spacecraft in case of unforeseen failures during the approach phase. <span class="hlt">Considerations</span> to create a simulation for the described mission are presented and discussed. A first visualization of pre-calculated aboard trajectories can be found at the end of this paper.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27182746','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27182746"><span>Specialty Practice and Cost <span class="hlt">Considerations</span> in the Management of Uveitis Associated With Juvenile Idiopathic Arthritis.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Palestine, Alan G; Singh, Jasleen K; Kolfenbach, Jason R; Ozzello, Daniel J</p> <p>2016-07-01</p> <p>To evaluate whether cost, prior insurance authorization concerns, and subspecialty practice influence therapeutic decisions in the treatment of uveitis associated with juvenile idiopathic arthritis. A total of 2,965 pediatric ophthalmologists, uveitis specialists, retina specialists, and rheumatologists across the United States were surveyed via e-mail regarding their choice in long-term therapy for a hypothetical patient with uveitis associated with juvenile idiopathic arthritis. Outcomes of interest were <span class="hlt">differences</span> in therapy choice based on cost/prior authorization and specialty practice. There were significant <span class="hlt">differences</span> in the use of methotrexate and biologics among specialists, both with and without <span class="hlt">consideration</span> for cost and prior authorization. Physicians in four <span class="hlt">different</span> specialties who treat uveitis associated with juvenile idiopathic arthritis agree on methotrexate as a first-line treatment choice and a biologic immunosuppressive medication as a second choice, but there are significant <span class="hlt">differences</span> between the specialties in their use of these medications. Cost and insurance <span class="hlt">considerations</span> did not affect therapy selection. [J Pediatr Ophthalmol Strabismus. 2016;53(4):246-251.]. Copyright 2016, SLACK Incorporated.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_19 --> <div id="page_20" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="381"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2010ApJ...713.1376F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2010ApJ...713.1376F"><span>Damping of Magnetohydrodynamic Turbulence in Partially Ionized Gas and the <span class="hlt">Observed</span> <span class="hlt">Difference</span> of Velocities of Neutrals and Ions</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Falceta-Gonçalves, D.; Lazarian, A.; Houde, M.</p> <p>2010-04-01</p> <p>Theoretical and <span class="hlt">observational</span> studies on the turbulence of the interstellar medium developed fast in the past decades. The theory of supersonic magnetized turbulence, as well as the understanding of the projection effects of <span class="hlt">observed</span> quantities, is still in progress. In this work, we explore the characterization of the turbulent cascade and its damping from <span class="hlt">observational</span> spectral line profiles. We address the <span class="hlt">difference</span> of ion and neutral velocities by clarifying the nature of the turbulence damping in the partially ionized. We provide theoretical arguments in favor of the explanation of the larger Doppler broadening of lines arising from neutral species compared to ions as arising from the turbulence damping of ions at larger scales. Also, we compute a number of MHD numerical simulations for <span class="hlt">different</span> turbulent regimes and explicit turbulent damping, and compare both the three-dimensional distributions of velocity and the synthetic line profile distributions. From the numerical simulations, we place constraints on the precision with which one can measure the three-dimensional dispersion depending on the turbulence sonic Mach number. We show that no universal correspondence between the three-dimensional velocity dispersions measured in the turbulent volume and minima of the two-dimensional velocity dispersions available through <span class="hlt">observations</span> exist. For instance, for subsonic turbulence the correspondence is poor at scales much smaller than the turbulence injection scale, while for supersonic turbulence the correspondence is poor for the scales comparable with the injection scale. We provide a physical explanation of the existence of such a two-dimensional to three-dimensional correspondence and discuss the uncertainties in evaluating the damping scale of ions that can be obtained from <span class="hlt">observations</span>. However, we show that the statistics of velocity dispersion from <span class="hlt">observed</span> line profiles can provide the spectral index and the energy transfer rate of turbulence. Also</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title40-vol26/pdf/CFR-2012-title40-vol26-sec194-51.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title40-vol26/pdf/CFR-2012-title40-vol26-sec194-51.pdf"><span>40 CFR 194.51 - <span class="hlt">Consideration</span> of protected individual.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-07-01</p> <p>... 40 Protection of Environment 26 2012-07-01 2011-07-01 true <span class="hlt">Consideration</span> of protected individual. 194.51 Section 194.51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION... Individual and Ground-Water Protection Requirements § 194.51 <span class="hlt">Consideration</span> of protected individual...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title40-vol25/pdf/CFR-2014-title40-vol25-sec194-51.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title40-vol25/pdf/CFR-2014-title40-vol25-sec194-51.pdf"><span>40 CFR 194.51 - <span class="hlt">Consideration</span> of protected individual.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-07-01</p> <p>... 40 Protection of Environment 25 2014-07-01 2014-07-01 false <span class="hlt">Consideration</span> of protected individual. 194.51 Section 194.51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION... Individual and Ground-Water Protection Requirements § 194.51 <span class="hlt">Consideration</span> of protected individual...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title40-vol25/pdf/CFR-2011-title40-vol25-sec194-51.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title40-vol25/pdf/CFR-2011-title40-vol25-sec194-51.pdf"><span>40 CFR 194.51 - <span class="hlt">Consideration</span> of protected individual.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-07-01</p> <p>... 40 Protection of Environment 25 2011-07-01 2011-07-01 false <span class="hlt">Consideration</span> of protected individual. 194.51 Section 194.51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION... Individual and Ground-Water Protection Requirements § 194.51 <span class="hlt">Consideration</span> of protected individual...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title40-vol26/pdf/CFR-2013-title40-vol26-sec194-51.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title40-vol26/pdf/CFR-2013-title40-vol26-sec194-51.pdf"><span>40 CFR 194.51 - <span class="hlt">Consideration</span> of protected individual.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-07-01</p> <p>... 40 Protection of Environment 26 2013-07-01 2013-07-01 false <span class="hlt">Consideration</span> of protected individual. 194.51 Section 194.51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION... Individual and Ground-Water Protection Requirements § 194.51 <span class="hlt">Consideration</span> of protected individual...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/10808660','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/10808660"><span>Sex <span class="hlt">differences</span> in principal farm operators' tractor driving safety beliefs and behaviors.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cole, H P; Westneat, S C; Browning, S R; Piercy, L R; Struttmann, T</p> <p>2000-01-01</p> <p>To examine the widely accepted hypothesis that farm women are more concerned with safety issues and behaviors than their male counterparts are. A telephone survey was administered to a random sample of Kentucky principal farm operators, 90 of whom were women. Participants were questioned about their tractor safety beliefs and practices. No significant sex <span class="hlt">differences</span> in tractor safety perceptions and behavior were <span class="hlt">observed</span>. Socialization of women to the role of principal farm operator may override their typically greater sensitivity to safety issues, an important <span class="hlt">consideration</span> when designing safety campaigns for this population.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25259757','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25259757"><span>A comparison of four <span class="hlt">different</span> lens mappers.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Larrue, Denis; Legeard, Morgane</p> <p>2014-11-01</p> <p>Recently, a number of lens mappers have become available for measuring the detailed optical properties of progressive addition lenses (PALs). The goal of this study was to compare the results obtained from several <span class="hlt">different</span> lens mappers for a range of <span class="hlt">different</span> lenses. The optical power maps of six lenses-two single-vision lenses, a parallel-sided slide, a flat prism, and two progressive lenses-were measured using four <span class="hlt">different</span> lens mappers: the Dual Lens Mapper, the Nimo TR4005, the Rotlex Class Plus, and the Visionix VM2500. The repeatability of the instruments was also evaluated. All lens mappers gave very repeatable measurements; however, measurements among the lens mappers varied <span class="hlt">considerably</span>. <span class="hlt">Differences</span> appeared to be above the tolerance at the optical center for measurements of single-vision lenses, and these <span class="hlt">differences</span> increase in the periphery up to 1.00 diopter. Similar <span class="hlt">differences</span> were <span class="hlt">observed</span> for the PALs, even increased by prism and base curve effect, with figures greater than 1 diopter in the periphery. The measurements made on the prism and lenses with <span class="hlt">different</span> base curves suggest that base curve, thickness, and prismatic effect can all contribute to the <span class="hlt">differences</span> among instruments. Measurements of a given lens taken with <span class="hlt">different</span> lens mappers can vary substantially. Particular caution should be exercised when interpreting power maps for PALs taken with <span class="hlt">different</span> instruments.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24348229','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24348229"><span>Amino acid changes in disease-associated variants <span class="hlt">differ</span> radically from variants <span class="hlt">observed</span> in the 1000 genomes project dataset.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>de Beer, Tjaart A P; Laskowski, Roman A; Parks, Sarah L; Sipos, Botond; Goldman, Nick; Thornton, Janet M</p> <p>2013-01-01</p> <p>The 1000 Genomes Project data provides a natural background dataset for amino acid germline mutations in humans. Since the direction of mutation is known, the amino acid exchange matrix generated from the <span class="hlt">observed</span> nucleotide variants is asymmetric and the mutabilities of the <span class="hlt">different</span> amino acids are very <span class="hlt">different</span>. These <span class="hlt">differences</span> predominantly reflect preferences for nucleotide mutations in the DNA (especially the high mutation rate of the CpG dinucleotide, which makes arginine mutability very much higher than other amino acids) rather than selection imposed by protein structure constraints, although there is evidence for the latter as well. The variants occur predominantly on the surface of proteins (82%), with a slight preference for sites which are more exposed and less well conserved than random. Mutations to functional residues occur about half as often as expected by chance. The disease-associated amino acid variant distributions in OMIM are radically <span class="hlt">different</span> from those expected on the basis of the 1000 Genomes dataset. The disease-associated variants preferentially occur in more conserved sites, compared to 1000 Genomes mutations. Many of the amino acid exchange profiles appear to exhibit an anti-correlation, with common exchanges in one dataset being rare in the other. Disease-associated variants exhibit more extreme <span class="hlt">differences</span> in amino acid size and hydrophobicity. More modelling of the mutational processes at the nucleotide level is needed, but these <span class="hlt">observations</span> should contribute to an improved prediction of the effects of specific variants in humans.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title22-vol1/pdf/CFR-2013-title22-vol1-sec214-12.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title22-vol1/pdf/CFR-2013-title22-vol1-sec214-12.pdf"><span>22 CFR 214.12 - <span class="hlt">Considerations</span> in membership selection.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-04-01</p> <p>... 22 Foreign Relations 1 2013-04-01 2013-04-01 false <span class="hlt">Considerations</span> in membership selection. 214.12... Establishment of Advisory Committees § 214.12 <span class="hlt">Considerations</span> in membership selection. Membership is to be fairly... also given to factors of sex, race, creed, national origin, and religion. ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title22-vol1/pdf/CFR-2011-title22-vol1-sec214-12.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title22-vol1/pdf/CFR-2011-title22-vol1-sec214-12.pdf"><span>22 CFR 214.12 - <span class="hlt">Considerations</span> in membership selection.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-04-01</p> <p>... 22 Foreign Relations 1 2011-04-01 2011-04-01 false <span class="hlt">Considerations</span> in membership selection. 214.12... Establishment of Advisory Committees § 214.12 <span class="hlt">Considerations</span> in membership selection. Membership is to be fairly... also given to factors of sex, race, creed, national origin, and religion. ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title22-vol1/pdf/CFR-2012-title22-vol1-sec214-12.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title22-vol1/pdf/CFR-2012-title22-vol1-sec214-12.pdf"><span>22 CFR 214.12 - <span class="hlt">Considerations</span> in membership selection.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-04-01</p> <p>... 22 Foreign Relations 1 2012-04-01 2012-04-01 false <span class="hlt">Considerations</span> in membership selection. 214.12... Establishment of Advisory Committees § 214.12 <span class="hlt">Considerations</span> in membership selection. Membership is to be fairly... also given to factors of sex, race, creed, national origin, and religion. ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title22-vol1/pdf/CFR-2014-title22-vol1-sec214-12.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title22-vol1/pdf/CFR-2014-title22-vol1-sec214-12.pdf"><span>22 CFR 214.12 - <span class="hlt">Considerations</span> in membership selection.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-04-01</p> <p>... 22 Foreign Relations 1 2014-04-01 2014-04-01 false <span class="hlt">Considerations</span> in membership selection. 214.12... Establishment of Advisory Committees § 214.12 <span class="hlt">Considerations</span> in membership selection. Membership is to be fairly... also given to factors of sex, race, creed, national origin, and religion. ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title22-vol1/pdf/CFR-2010-title22-vol1-sec214-12.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title22-vol1/pdf/CFR-2010-title22-vol1-sec214-12.pdf"><span>22 CFR 214.12 - <span class="hlt">Considerations</span> in membership selection.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-04-01</p> <p>... 22 Foreign Relations 1 2010-04-01 2010-04-01 false <span class="hlt">Considerations</span> in membership selection. 214.12 Section 214.12 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ADVISORY COMMITTEE MANAGEMENT Establishment of Advisory Committees § 214.12 <span class="hlt">Considerations</span> in membership selection. Membership is to be fairly...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol1/pdf/CFR-2010-title49-vol1-sec37-147.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol1/pdf/CFR-2010-title49-vol1-sec37-147.pdf"><span>49 CFR 37.147 - <span class="hlt">Considerations</span> during FTA review.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... 49 Transportation 1 2010-10-01 2010-10-01 false <span class="hlt">Considerations</span> during FTA review. 37.147 Section 37.147 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Paratransit as a Complement to Fixed Route Service § 37.147 <span class="hlt">Considerations</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title49-vol5/pdf/CFR-2011-title49-vol5-sec389-23.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title49-vol5/pdf/CFR-2011-title49-vol5-sec389-23.pdf"><span>49 CFR 389.23 - <span class="hlt">Consideration</span> of comments received.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... 49 Transportation 5 2011-10-01 2011-10-01 false <span class="hlt">Consideration</span> of comments received. 389.23 Section 389.23 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER... PROCEDURES-FEDERAL MOTOR CARRIER SAFETY REGULATIONS Procedures for Adoption of Rules § 389.23 <span class="hlt">Consideration</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol5/pdf/CFR-2010-title49-vol5-sec389-23.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol5/pdf/CFR-2010-title49-vol5-sec389-23.pdf"><span>49 CFR 389.23 - <span class="hlt">Consideration</span> of comments received.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... 49 Transportation 5 2010-10-01 2010-10-01 false <span class="hlt">Consideration</span> of comments received. 389.23 Section 389.23 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER... PROCEDURES-FEDERAL MOTOR CARRIER SAFETY REGULATIONS Procedures for Adoption of Rules § 389.23 <span class="hlt">Consideration</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013EGUGA..15.6315K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013EGUGA..15.6315K"><span>Analysis of the interplanetary magnetic field <span class="hlt">observations</span> at <span class="hlt">different</span> heliocentric distances</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Khabarova, Olga</p> <p>2013-04-01</p> <p>Multi-spacecraft measurements of the interplanetary magnetic field (IMF) from 0.29 AU to 5 AU along the ecliptic plane have demonstrated systematic deviations of the <span class="hlt">observed</span> IMF strength from the values predicted on the basis of the Parker-like radial extension models (Khabarova, Obridko, 2012). In particular, it was found that the radial IMF component |Br| decreases with a heliocentric distance r with a slope of -5/3 (instead of r-2 expansion law). The current investigation of multi-point <span class="hlt">observations</span> continues the analysis of the IMF (and, especially, Br) large-scale behaviour, including its latitudinal distribution. Additionally, examples of the mismatches between the expected IMF characteristics and <span class="hlt">observations</span> at smaller scales are discussed. It is shown that the <span class="hlt">observed</span> effects may be explained by not complete IMF freezing-in to the solar wind plasma. This research was supported by the Russian Fund of Basic Researches' grants Nos.11-02-00259-a, and 12-02-10008-K. Khabarova Olga, and Obridko Vladimir, Puzzles of the Interplanetary Magnetic Field in the Inner Heliosphere, 2012, Astrophysical Journal, 761, 2, 82, doi:10.1088/0004-637X/761/2/82, http://arxiv.org/pdf/1204.6672v2.pdf</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20160004750','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20160004750"><span>Scheduler Design Criteria: Requirements and <span class="hlt">Considerations</span></span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Lee, Hanbong</p> <p>2016-01-01</p> <p>This presentation covers fundamental requirements and <span class="hlt">considerations</span> for developing schedulers in airport operations. We first introduce performance and functional requirements for airport surface schedulers. Among various optimization problems in airport operations, we focus on airport surface scheduling problem, including runway and taxiway operations. We then describe a basic methodology for airport surface scheduling such as node-link network model and scheduling algorithms previously developed. Next, we explain how to design a mathematical formulation in more details, which consists of objectives, decision variables, and constraints. Lastly, we review other <span class="hlt">considerations</span>, including optimization tools, computational performance, and performance metrics for evaluation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2749585','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2749585"><span>Preoperative Medical Evaluation: Part 1: General Principles and Cardiovascular <span class="hlt">Considerations</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Becker, Daniel E</p> <p>2009-01-01</p> <p>A thorough assessment of a patient's medical status is standard practice when dental care is provided. Although this is true for procedures performed under local anesthesia alone, the information gathered may be viewed somewhat <span class="hlt">differently</span> if the dentist is planning to use sedation or general anesthesia as an adjunct to dental treatment. This article is the first of a 2-part sequence and will address general principles and cardiovascular <span class="hlt">considerations</span>. A second article will address pulmonary, metabolic, and miscellaneous disorders. PMID:19769423</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2003AAS...202.3811W','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2003AAS...202.3811W"><span>Robotic Observatory System Design-Specification <span class="hlt">Considerations</span> for Achieving Long-Term Sustainable Precision Performance</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Wray, J. D.</p> <p>2003-05-01</p> <p>The robotic observatory telescope must point precisely on the target object, and then track autonomously to a fraction of the FWHM of the system PSF for durations of ten to twenty minutes or more. It must retain this precision while continuing to function at rates approaching thousands of <span class="hlt">observations</span> per night for all its years of useful life. These stringent requirements raise new challenges unique to robotic telescope systems design. Critical design <span class="hlt">considerations</span> are driven by the applicability of the above requirements to all systems of the robotic observatory, including telescope and instrument systems, telescope-dome enclosure systems, combined electrical and electronics systems, environmental (e.g. seeing) control systems and integrated computer control software systems. Traditional telescope design <span class="hlt">considerations</span> include the effects of differential thermal strain, elastic flexure, plastic flexure and slack or backlash with respect to focal stability, optical alignment and angular pointing and tracking precision. Robotic observatory design must holistically encapsulate these traditional <span class="hlt">considerations</span> within the overall objective of maximized long-term sustainable precision performance. This overall objective is accomplished through combining appropriate mechanical and dynamical system characteristics with a full-time real-time telescope mount model feedback computer control system. Important design <span class="hlt">considerations</span> include: identifying and reducing quasi-zero-backlash; increasing size to increase precision; directly encoding axis shaft rotation; pointing and tracking operation via real-time feedback between precision mount model and axis mounted encoders; use of monolithic construction whenever appropriate for sustainable mechanical integrity; accelerating dome motion to eliminate repetitive shock; ducting internal telescope air to outside dome; and the principal design criteria: maximizing elastic repeatability while minimizing slack, plastic deformation</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_20 --> <div id="page_21" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="401"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012AGUFMPP11F..01B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012AGUFMPP11F..01B"><span>Constraining the temperature history of the past millennium using early instrumental <span class="hlt">observations</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Brohan, P.</p> <p>2012-12-01</p> <p>The current assessment that twentieth-century global temperature change is unusual in the context of the last thousand years relies on estimates of temperature changes from natural proxies (tree-rings, ice-cores etc.) and climate model simulations. Confidence in such estimates is limited by difficulties in calibrating the proxies and systematic <span class="hlt">differences</span> between proxy reconstructions and model simulations - notable <span class="hlt">differences</span> include large <span class="hlt">differences</span> in multi-decadal variability between proxy reconstructions, and big uncertainties in the effect of volcanic eruptions. Because the <span class="hlt">difference</span> between the estimates extends into the relatively recent period of the early nineteenth century it is possible to compare them with a reliable instrumental estimate of the temperature change over that period, provided that enough early thermometer <span class="hlt">observations</span>, covering a wide enough expanse of the world, can be collected. By constraining key aspects of the reconstructions and simulations, instrumental <span class="hlt">observations</span>, inevitably from a limited period, can reduce reconstruction uncertainty throughout the millennium. A <span class="hlt">considerable</span> quantity of early instrumental <span class="hlt">observations</span> are preserved in the world's archives. One organisation which systematically made <span class="hlt">observations</span> and collected the results was the English East-India Company (EEIC), and 900 log-books of EEIC ships containing daily instrumental measurements of temperature and pressure have been preserved in the British Library. Similar records from voyages of exploration and scientific investigation are preserved in published literature and the records in National Archives. Some of these records have been extracted and digitised, providing hundreds of thousands of new weather records offering an unprecedentedly detailed view of the weather and climate of the late eighteenth and early nineteenth centuries. The new thermometer <span class="hlt">observations</span> demonstrate that the large-scale temperature response to the Tambora eruption and the 1809</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title48-vol3/pdf/CFR-2010-title48-vol3-sec215-404-3.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title48-vol3/pdf/CFR-2010-title48-vol3-sec215-404-3.pdf"><span>48 CFR 215.404-3 - Subcontract pricing <span class="hlt">considerations</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Subcontract pricing <span class="hlt">considerations</span>. 215.404-3 Section 215.404-3 Federal Acquisition Regulations System DEFENSE ACQUISITION... Contract Pricing 215.404-3 Subcontract pricing <span class="hlt">considerations</span>. Follow the procedures at PGI 215.404-3 when...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title40-vol24/pdf/CFR-2010-title40-vol24-sec194-51.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title40-vol24/pdf/CFR-2010-title40-vol24-sec194-51.pdf"><span>40 CFR 194.51 - <span class="hlt">Consideration</span> of protected individual.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-07-01</p> <p>... 40 Protection of Environment 24 2010-07-01 2010-07-01 false <span class="hlt">Consideration</span> of protected individual... Individual and Ground-Water Protection Requirements § 194.51 <span class="hlt">Consideration</span> of protected individual. Compliance assessments that analyze compliance with § 191.15 of this chapter shall assume that an individual...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title40-vol25/pdf/CFR-2014-title40-vol25-sec194-52.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title40-vol25/pdf/CFR-2014-title40-vol25-sec194-52.pdf"><span>40 CFR 194.52 - <span class="hlt">Consideration</span> of exposure pathways.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-07-01</p> <p>... 40 Protection of Environment 25 2014-07-01 2014-07-01 false <span class="hlt">Consideration</span> of exposure pathways... Individual and Ground-Water Protection Requirements § 194.52 <span class="hlt">Consideration</span> of exposure pathways. In compliance assessments that analyze compliance with § 191.15 of this chapter, all potential exposure pathways...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title40-vol24/pdf/CFR-2010-title40-vol24-sec194-52.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title40-vol24/pdf/CFR-2010-title40-vol24-sec194-52.pdf"><span>40 CFR 194.52 - <span class="hlt">Consideration</span> of exposure pathways.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-07-01</p> <p>... 40 Protection of Environment 24 2010-07-01 2010-07-01 false <span class="hlt">Consideration</span> of exposure pathways... Individual and Ground-Water Protection Requirements § 194.52 <span class="hlt">Consideration</span> of exposure pathways. In compliance assessments that analyze compliance with § 191.15 of this chapter, all potential exposure pathways...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title40-vol25/pdf/CFR-2011-title40-vol25-sec194-52.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title40-vol25/pdf/CFR-2011-title40-vol25-sec194-52.pdf"><span>40 CFR 194.52 - <span class="hlt">Consideration</span> of exposure pathways.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-07-01</p> <p>... 40 Protection of Environment 25 2011-07-01 2011-07-01 false <span class="hlt">Consideration</span> of exposure pathways... Individual and Ground-Water Protection Requirements § 194.52 <span class="hlt">Consideration</span> of exposure pathways. In compliance assessments that analyze compliance with § 191.15 of this chapter, all potential exposure pathways...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title40-vol26/pdf/CFR-2012-title40-vol26-sec194-52.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title40-vol26/pdf/CFR-2012-title40-vol26-sec194-52.pdf"><span>40 CFR 194.52 - <span class="hlt">Consideration</span> of exposure pathways.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-07-01</p> <p>... 40 Protection of Environment 26 2012-07-01 2011-07-01 true <span class="hlt">Consideration</span> of exposure pathways. 194... Individual and Ground-Water Protection Requirements § 194.52 <span class="hlt">Consideration</span> of exposure pathways. In compliance assessments that analyze compliance with § 191.15 of this chapter, all potential exposure pathways...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title40-vol26/pdf/CFR-2013-title40-vol26-sec194-52.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title40-vol26/pdf/CFR-2013-title40-vol26-sec194-52.pdf"><span>40 CFR 194.52 - <span class="hlt">Consideration</span> of exposure pathways.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-07-01</p> <p>... 40 Protection of Environment 26 2013-07-01 2013-07-01 false <span class="hlt">Consideration</span> of exposure pathways... Individual and Ground-Water Protection Requirements § 194.52 <span class="hlt">Consideration</span> of exposure pathways. In compliance assessments that analyze compliance with § 191.15 of this chapter, all potential exposure pathways...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=types+AND+organizational+AND+structure&pg=3&id=EJ1020145','ERIC'); return false;" href="https://eric.ed.gov/?q=types+AND+organizational+AND+structure&pg=3&id=EJ1020145"><span>Are History Textbooks More "<span class="hlt">Considerate</span>" after 20 Years?</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Berkeley, Sheri; King-Sears, Margaret E.; Hott, Brittany L.; Bradley-Black, Katherine</p> <p>2014-01-01</p> <p>Features of eighth-grade history textbooks were examined through replication of a 20-year-old study that investigated "<span class="hlt">considerateness</span>" of textbooks. <span class="hlt">Considerate</span> texts provide clear, coherent information and include features that promote students' comprehension, such as explicit use of organizational structures, a range of question types…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017PrOce.156...41M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017PrOce.156...41M"><span>The impact of the ocean <span class="hlt">observing</span> system on estimates of the California current circulation spanning three decades</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Moore, Andrew M.; Jacox, Michael G.; Crawford, William J.; Laughlin, Bruce; Edwards, Christopher A.; Fiechter, Jérôme</p> <p>2017-08-01</p> <p>Data assimilation is now used routinely in oceanography on both regional and global scales for computing ocean circulation estimates and for making ocean forecasts. Regional ocean <span class="hlt">observing</span> systems are also expanding rapidly, and <span class="hlt">observations</span> from a wide array of <span class="hlt">different</span> platforms and sensor types are now available. Evaluation of the impact of the <span class="hlt">observing</span> system on ocean circulation estimates (and forecasts) is therefore of <span class="hlt">considerable</span> interest to the oceanographic community. In this paper, we quantify the impact of <span class="hlt">different</span> <span class="hlt">observing</span> platforms on estimates of the California Current System (CCS) spanning a three decade period (1980-2010). Specifically, we focus attention on several dynamically related aspects of the circulation (coastal upwelling, the transport of the California Current and the California Undercurrent, thermocline depth and eddy kinetic energy) which in many ways describe defining characteristics of the CCS. The circulation estimates were computed using a 4-dimensional variational (4D-Var) data assimilation system, and our analyses also focus on the impact of the <span class="hlt">different</span> elements of the control vector (i.e. the initial conditions, surface forcing, and open boundary conditions) on the circulation. While the influence of each component of the control vector varies between <span class="hlt">different</span> metrics of the circulation, the impact of each <span class="hlt">observing</span> system across metrics is very robust. In addition, the mean amplitude of the circulation increments (i.e. the <span class="hlt">difference</span> between the analysis and background) remains relatively stable throughout the three decade period despite the addition of new <span class="hlt">observing</span> platforms whose impact is redistributed according to the relative uncertainty of <span class="hlt">observations</span> from each platform. We also consider the impact of each <span class="hlt">observing</span> platform on CCS circulation variability associated with low-frequency climate variability. The low-frequency nature of the dominant climate modes in this region allows us to track through time the</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018ISPAr42.3..857L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018ISPAr42.3..857L"><span>Retrieval of Aerosol Phase Function and Polarized Phase Function from Polarization of Skylight for <span class="hlt">Different</span> <span class="hlt">Observation</span> Geometries</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Li, L.; Qie, L. L.; Xu, H.; Li, Z. Q.</p> <p>2018-04-01</p> <p>The phase function and polarized phase function are important optical parameters, which describe scattering properties of atmospheric aerosol particles. Polarization of skylight induced by the scattering processes is sensitive to the scattering properties of aerosols. The Stokes parameters I, Q, U and the polarized radiance Lp of skylight measured by the CIMEL dual-polar sun-sky radiometer CE318- DP can be use to retrieve the phase function and polarized phase function, respectively. Two <span class="hlt">different</span> <span class="hlt">observation</span> geometries (i.e., the principal plane and almucantar) are preformed by the CE318-DP to detect skylight polarization. Polarization of skylight depends on the illumination and <span class="hlt">observation</span> geometries. For the same solar zenith angle, retrievals of the phase function and the polarized phase function are still affected by the <span class="hlt">observation</span> geometry. The performance of the retrieval algorithm for the principal plane and almucantar <span class="hlt">observation</span> geometries was assessed by the numerical experiments at two typical high and low sun's positions (i.e. solar zenith angles are equal to 45° and 65°). Comparing the results for the principal plane and almucantar geometries, it is recommended to utilize the principal plane <span class="hlt">observations</span> to retrieve the phase function when the solar zenith angle is small. The Stokes parameter U and the polarized radiance Lp from the almucantar <span class="hlt">observations</span> are suggested to retrieve the polarized phase function, especially for short wavelength channels (e.g., 440 and 500 nm).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://rosap.ntl.bts.gov/view/dot/12278','DOTNTL'); return false;" href="https://rosap.ntl.bts.gov/view/dot/12278"><span>Apache Trail, Tonto National Forest : <span class="hlt">Observations</span>, <span class="hlt">Considerations</span>, and Recommendations from the Interagency Transportation Assistance Group (TAG)</span></a></p> <p><a target="_blank" href="http://ntlsearch.bts.gov/tris/index.do">DOT National Transportation Integrated Search</a></p> <p></p> <p>2016-03-03</p> <p>This report summarizes the <span class="hlt">observations</span> and findings of an interagency transportation assistance group (TAG) convened to discuss the long-term future of Arizona State Route 88, also known as the Apache Trail, a historic road on the Tonto Nation...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018PhLA..382..503A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018PhLA..382..503A"><span>Evolution of the characteristics of Parametric X-ray Radiation from textured polycrystals under <span class="hlt">different</span> <span class="hlt">observation</span> angles</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Alekseev, V. I.; Eliseyev, A. N.; Irribarra, E.; Kishin, I. A.; Klyuev, A. S.; Kubankin, A. S.; Nazhmudinov, R. M.; Zhukova, P. N.</p> <p>2018-02-01</p> <p>The Parametric X-Ray radiation (PXR) spectra and yield dependencies on the orientation angle are measured during the interaction of 7 MeV electrons with a tungsten textured polycrystalline foil for <span class="hlt">different</span> <span class="hlt">observation</span> angles. The effects of PXR spectral density increase and PXR yield orientation dependence broadening in the backward direction is shown experimentally for the first time. The experimental results are compared with PXR kinematical theories for both mosaic crystals and polycrystals.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26178730','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26178730"><span>Eating under <span class="hlt">observation</span>: a systematic review and meta-analysis of the effect that heightened awareness of <span class="hlt">observation</span> has on laboratory measured energy intake.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Robinson, Eric; Hardman, Charlotte A; Halford, Jason C G; Jones, Andrew</p> <p>2015-08-01</p> <p>Laboratory paradigms are commonly used to study human energy intake. However, the extent to which participants believe their eating behavior is being measured may affect energy intake and is a methodologic factor that has received little <span class="hlt">consideration</span>. Our main objective was to examine available evidence for the effect that heightened awareness of <span class="hlt">observation</span> has on energy intake in a laboratory setting. We systematically reviewed laboratory studies that allowed for experimental examination of the effect that heightened awareness of <span class="hlt">observation</span> has on energy intake. From these experimental studies we combined effect estimates using inverse variance meta-analysis, calculating the standardized mean <span class="hlt">difference</span> (SMD) in energy intake between heightened-awareness and control conditions and qualitatively synthesized potential moderators of this effect. Nine studies, providing 22 comparisons, were eligible for inclusion. These studies largely sampled young women and examined the energy intake of energy-dense snack foods. Evidence indicated that heightened awareness of <span class="hlt">observation</span> was associated with reduced energy intake when compared with the control condition (random-effects SMD: 0.45; 95% CI: 0.25, 0.66; P < 0.0001). We found little evidence that the type of experimental manipulation used to heighten awareness moderated the overall effect. The available evidence to date suggests that heightened awareness of <span class="hlt">observation</span> reduces energy intake in a laboratory setting. These findings suggest that laboratory studies should attempt to minimize the degree to which participants are aware that their eating behavior is being measured. © 2015 American Society for Nutrition.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1993PhR...227..113W','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1993PhR...227..113W"><span><span class="hlt">Observational</span> and theoretical spectra of supernovae</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Wheeler, J. Craig; Swartz, Douglas A.; Harkness, Robert P.</p> <p>1993-05-01</p> <p>Progress in nuclear astrophysics by means of quantitative supernova spectroscopy is discussed with special concentration on type Ia, Ib and Ic and on SN 1987A. Spectral calculations continue to support an exploding C/O white dwarf as the best model of a SN Ia. Deflagration model W7 produces good maximum light spectra of SN Ia and seems to have a better composition distribution compared to delayed detonation models, but proper treatment of opacity remains a problem and the physical basis of SN Ia explosions is still not completely understood. All models for SN Ia predict large quantities of 56Co in the ejecta, but it is not clear that <span class="hlt">observations</span> confirm this. Although the evolutionary origin of SN Ia remains uncertain, there is recent evidence that transfer of hydrogen in a binary system may be involved, as long suspected. There has been progress in comparing dynamical models with the optical/IR spectra of SN 1987A. The evolution of the [OI] λλ6300, 6364 feature and the presence of strong persistent HeI λ10 830 indicate that both the envelope and core material contribute substantially to the formation of emission lines in the nebular phase and that neither the core nor the envelope can be neglected. Blending with nearby hydrogen lines may affect both of these spectral features, thereby complicating the analysis of the lines. The effects of continuum transfer and photoionization have been included and are under study. The discrepancies between theoretical and <span class="hlt">observed</span> spectra are due primarily to the one-dimensional hydrodynamic models. The spectral data are not consistent with the high density ``spike'' (in radial coordinate) of the core material that is predicted by all such models. Analysis of the light curves of SN Ib and SN Ic supernovae implies that there are significant <span class="hlt">differences</span> in their physical properties. Some SN Ib have <span class="hlt">considerably</span> more ejecta mass than SN Ic events. SN Ib require He-rich atmospheres to produce the <span class="hlt">observed</span> strong optical lines of</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1993PhR...227..113C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1993PhR...227..113C"><span><span class="hlt">Observational</span> and theoretical spectra of supernovae</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Craig Wheeler, J.; Swartz, Douglas A.; Harkness, Robert P.</p> <p>1993-05-01</p> <p>Progress in nuclear astrophysics by means of quantitative supernova spectroscopy is discussed with special concentration on type Ia, Ib and Ic and on SN 1987A. Spectral calculations continue to support an exploding C/O white dwarf as the best model of a SN Ia. Deflagration model W7 produces good maximum light spectra of SN Ia and seems to have a better composition distribution compared to delayed detonation models, but proper treatment of opacity remains a problem and the physical basis of SN Ia explosions is still not completely understood. All models for SN Ia predict large quantities of 56Co in the ejecta, but it is not clear that <span class="hlt">observations</span> confirm this. Although the evolutionary origin of SN Ia remains uncertain, there is recent evidence that transfer of hydrogen in a binary system may be involved, as long suspected. There has been progress in comparing dynamical models with the optical/IR spectra of SN 1987A. The evolution of the [OI] λλ6300, 6364 feature and the presence of strong persistent HeI λ10 830 indicate that both the envelope and core material contribute substantially to the formation of emission lines in the nebular phase and that neither the core nor the envelope can be neglected. Blending with nearby hydrogen lines may affect both of these spectral features, thereby complicating the analysis of the lines. The effects of continuum transfer and photoionization have been included and are under study. The discrepancies between theoretical and <span class="hlt">observed</span> spectra are due primarily to the one-dimensional hydrodynamic models. The spectral data are not consistent with the high density “spike” (in radial coordinate) of the core material that is predicted by all such models. Analysis of the light curves of SN Ib and SN Ic supernovae implies that there are significant <span class="hlt">differences</span> in their physical properties. Some SN Ib have <span class="hlt">considerably</span> more ejecta mass than SN Ic events. SN Ib require He-rich atmospheres to produce the <span class="hlt">observed</span> strong optical lines</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AGUFM.C51A0953Y','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AGUFM.C51A0953Y"><span>Comparing elevation and freeboard from IceBridge and four <span class="hlt">different</span> CryoSat-2 retrackers for coincident sea ice <span class="hlt">observations</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Yi, D.; Kurtz, N. T.; Harbeck, J.</p> <p>2017-12-01</p> <p>The airborne IceBridge and spaceborne Cryosat-2 missions <span class="hlt">observe</span> polar sea ice at <span class="hlt">different</span> altitudes with <span class="hlt">different</span> footprint sizes and often at <span class="hlt">different</span> time and locations. Many studies use <span class="hlt">different</span> retrackers to derive Cryosat-2 surface elevation, which we find causes large <span class="hlt">differences</span> in the elevation and freeboard comparisons of IceBridge and Cryosat-2. In this study, we compare sea ice surface elevation and freeboard using 8 coincident CryoSat-2, ATM, and LVIS <span class="hlt">observations</span> with IceBridge airplanes under flying the Cryosat-2 ground tracks. We apply identical ellipsoid, geoid model, tide model, and atmospheric correction to CryoSat-2 and IceBridge data to reduce elevation bias due to their <span class="hlt">differences</span>. IceBridge's ATM and LVIS elevation and freeboard and Snow Radar snow depth are averaged at each CryoSat-2 footprint for comparison. The four <span class="hlt">different</span> Cryosat-2 retrackers (ESA, GSFC, AWI, and JPL) show distinct <span class="hlt">differences</span> in mean elevation up to 0.35 meters over leads and over floes, which suggests that systematic elevation bias exists between the retrackers. The mean IceBridge elevation over leads is within the mean elevation distribution of the four Cryosat-2 retrackers. The mean IceBridge elevation over floes is above the mean elevation distribution of the four Cryosat-2 retrackers. After removing the snow depth from IceBridge elevation, over floe, the mean elevation of IceBridge is within the mean elevation distribution of the four Cryosat-2 retrackers. By identifying the strengths and weaknesses of the retrackers, this study provides a mechanism to improve freeboard retrievals from existing methods.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5456668','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5456668"><span>Cyclic Behavior of Mortarless Brick Joints with <span class="hlt">Different</span> Interlocking Shapes</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Liu, Hongjun; Liu, Peng; Lin, Kun; Zhao, Sai</p> <p>2016-01-01</p> <p>The framed structure infilled with a mortarless brick (MB) panel exhibits <span class="hlt">considerable</span> in-plane energy dissipation because of the relative sliding between bricks and good out-of-plane stability resulting from the use of interlocking mechanisms. The cyclic behaviors of MB are investigated experimentally in this study. Two <span class="hlt">different</span> types of bricks, namely non-interlocking mortarless brick (N-IMB) and interlocking mortarless brick (IMB), are examined experimentally. The cyclic behavior of all of the joints (N-IMB and IMB) are investigated in <span class="hlt">consideration</span> of the effects of interlocking shapes, loading compression stress levels and loading cycles. The hysteretic loops of N-IMB and IMB joints are obtained, according to which a mechanical model is developed. The Mohr–Coulomb failure criterion is employed to describe the shear failure modes of all of the investigated joints. A typical frictional behavior is <span class="hlt">observed</span> for the N-IMB joints, and a significant stiffening effect is <span class="hlt">observed</span> for the IMB joints during their sliding stage. The friction coefficients of all of the researched joints increase with the augmentation of the compression stress level and improvement of the smoothness of the interlocking surfaces. An increase in the loading cycle results in a decrease in the friction coefficients of all of the joints. The degradation rate (DR) of the friction coefficients increases with the reduction in the smoothness of the interlocking surface. PMID:28773291</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2013-05-17/pdf/2013-11870.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2013-05-17/pdf/2013-11870.pdf"><span>78 FR 29117 - After Final <span class="hlt">Consideration</span> Pilot Program 2.0</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2013-05-17</p> <p>...] After Final <span class="hlt">Consideration</span> Pilot Program 2.0 AGENCY: United States Patent and Trademark Office, Commerce... Final <span class="hlt">Consideration</span> Pilot Program (AFCP) to create the After Final <span class="hlt">Consideration</span> Pilot Program 2.0 (AFCP... without modifications) depending on feedback from the participants and the effectiveness of the pilot...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27175970','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27175970"><span>To Cull or Not To Cull? <span class="hlt">Considerations</span> for Studies of Endocrine-Disrupting Chemicals.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Suvorov, Alexander; Vandenberg, Laura N</p> <p>2016-07-01</p> <p>The power of animal models is derived from the ability to control experimental variables so that <span class="hlt">observed</span> effects may be unequivocally attributed to the factor that was changed. One variable that is difficult to control in animal experiments is the number and composition of offspring in a litter. To account for this variability, artificial equalization of the number of offspring in a litter (culling) is often used. The rationale for culling, however, has always been controversial. The Developmental Origins of Health and Disease concept provides a new context to evaluate the pros and cons of culling in laboratory animal studies, especially in the context of endocrine-disrupting chemicals. Emerging evidence indicates that culling, especially of large litters, can drastically change the feeding status of a pup, which can result in compensatory growth with long-term consequences for the animal, including increased risk of cardio-metabolic diseases. Similarly, culling of litters to intentionally bias sex ratios can alter the animal's behavior and physiology, with effects <span class="hlt">observed</span> on a wide range of outcomes. Thus, in an attempt to control for variability in developmental rates, culling introduces an uncontrolled or confounding variable, which itself may affect a broad spectrum of health-related consequences. Variabilities in culling protocols could be responsible for <span class="hlt">differences</span> in responses to endocrine-disrupting chemicals reported across studies. Because litter sex composition and size are vectors that can influence both prenatal and postnatal growth, they are essential <span class="hlt">considerations</span> for the interpretation of results from laboratory animal studies.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_21 --> <div id="page_22" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="421"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4839216','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4839216"><span>267 Spanish Exomes Reveal Population-Specific <span class="hlt">Differences</span> in Disease-Related Genetic Variation</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Dopazo, Joaquín; Amadoz, Alicia; Bleda, Marta; Garcia-Alonso, Luz; Alemán, Alejandro; García-García, Francisco; Rodriguez, Juan A.; Daub, Josephine T.; Muntané, Gerard; Rueda, Antonio; Vela-Boza, Alicia; López-Domingo, Francisco J.; Florido, Javier P.; Arce, Pablo; Ruiz-Ferrer, Macarena; Méndez-Vidal, Cristina; Arnold, Todd E.; Spleiss, Olivia; Alvarez-Tejado, Miguel; Navarro, Arcadi; Bhattacharya, Shomi S.; Borrego, Salud; Santoyo-López, Javier; Antiñolo, Guillermo</p> <p>2016-01-01</p> <p>Recent results from large-scale genomic projects suggest that allele frequencies, which are highly relevant for medical purposes, <span class="hlt">differ</span> <span class="hlt">considerably</span> across <span class="hlt">different</span> populations. The need for a detailed catalog of local variability motivated the whole-exome sequencing of 267 unrelated individuals, representative of the healthy Spanish population. Like in other studies, a <span class="hlt">considerable</span> number of rare variants were found (almost one-third of the described variants). There were also relevant <span class="hlt">differences</span> in allelic frequencies in polymorphic variants, including ∼10,000 polymorphisms private to the Spanish population. The allelic frequencies of variants conferring susceptibility to complex diseases (including cancer, schizophrenia, Alzheimer disease, type 2 diabetes, and other pathologies) were overall similar to those of other populations. However, the trend is the opposite for variants linked to Mendelian and rare diseases (including several retinal degenerative dystrophies and cardiomyopathies) that show marked frequency <span class="hlt">differences</span> between populations. Interestingly, a correspondence between <span class="hlt">differences</span> in allelic frequencies and disease prevalence was found, highlighting the relevance of frequency <span class="hlt">differences</span> in disease risk. These <span class="hlt">differences</span> are also <span class="hlt">observed</span> in variants that disrupt known drug binding sites, suggesting an important role for local variability in population-specific drug resistances or adverse effects. We have made the Spanish population variant server web page that contains population frequency information for the complete list of 170,888 variant positions we found publicly available (http://spv.babelomics.org/), We show that it if fundamental to determine population-specific variant frequencies to distinguish real disease associations from population-specific polymorphisms. PMID:26764160</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013HydJ...21.1539R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013HydJ...21.1539R"><span>Effect of <span class="hlt">different</span> transport <span class="hlt">observations</span> on inverse modeling results: case study of a long-term groundwater tracer test monitored at high resolution</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Rasa, Ehsan; Foglia, Laura; Mackay, Douglas M.; Scow, Kate M.</p> <p>2013-11-01</p> <p>Conservative tracer experiments can provide information useful for characterizing various subsurface transport properties. This study examines the effectiveness of three <span class="hlt">different</span> types of transport <span class="hlt">observations</span> for sensitivity analysis and parameter estimation of a three-dimensional site-specific groundwater flow and transport model: conservative tracer breakthrough curves (BTCs), first temporal moments of BTCs ( m 1), and tracer cumulative mass discharge ( M d) through control planes combined with hydraulic head <span class="hlt">observations</span> ( h). High-resolution data obtained from a 410-day controlled field experiment at Vandenberg Air Force Base, California (USA), have been used. In this experiment, bromide was injected to create two adjacent plumes monitored at six <span class="hlt">different</span> transects (perpendicular to groundwater flow) with a total of 162 monitoring wells. A total of 133 <span class="hlt">different</span> <span class="hlt">observations</span> of transient hydraulic head, 1,158 of BTC concentration, 23 of first moment, and 36 of mass discharge were used for sensitivity analysis and parameter estimation of nine flow and transport parameters. The importance of each group of transport <span class="hlt">observations</span> in estimating these parameters was evaluated using sensitivity analysis, and five out of nine parameters were calibrated against these data. Results showed the advantages of using temporal moment of conservative tracer BTCs and mass discharge as <span class="hlt">observations</span> for inverse modeling.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018SerAJ.tmp....1K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018SerAJ.tmp....1K"><span><span class="hlt">Observations</span> and Light Curve Solutions of the Eclipsing Binaries KR Lyn, CSS J110212+244412, NSVS 4917488 and NSVS 7336024</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kjurkchieva, D.; Popov, V. A.; Eneva, J.; Petrov, N.</p> <p>2018-05-01</p> <p>We present photometric <span class="hlt">observations</span> in Sloan filters g', i' of the short-period eclipsing stars KR Lyn, CSS J110212+244412, NSVS 4917488 and NSVS 7336024. The light curve solutions revealed that all targets are overcontact binaries whose components are G and K stars. Their temperature <span class="hlt">differences</span> do not exceed 300 K but they <span class="hlt">differ</span> <span class="hlt">considerably</span> in size and mass. NSVS 4917488 and NSVS 7336024 reveal total eclipses and their parameters can be considered as well-determined. We found that KR Lyn, NSVS 4917488 and NSVS 7336024 are of W-subtype while CSS J110212+244412 is A-subtype W UMa-type star.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26611435','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26611435"><span>Embedding clinical interventions into <span class="hlt">observational</span> studies.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Newman, Anne B; Avilés-Santa, M Larissa; Anderson, Garnet; Heiss, Gerardo; Howard, Wm James; Krucoff, Mitchell; Kuller, Lewis H; Lewis, Cora E; Robinson, Jennifer G; Taylor, Herman; Treviño, Roberto P; Weintraub, William</p> <p>2016-01-01</p> <p>Novel approaches to <span class="hlt">observational</span> studies and clinical trials could improve the cost-effectiveness and speed of translation of research. Hybrid designs that combine elements of clinical trials with <span class="hlt">observational</span> registries or cohort studies should be considered as part of a long-term strategy to transform clinical trials and epidemiology, adapting to the opportunities of big data and the challenges of constrained budgets. Important <span class="hlt">considerations</span> include study aims, timing, breadth and depth of the existing infrastructure that can be leveraged, participant burden, likely participation rate and available sample size in the cohort, required sample size for the trial, and investigator expertise. Community engagement and stakeholder (including study participants) support are essential for these efforts to succeed. Copyright © 2015. Published by Elsevier Inc.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title30-vol2/pdf/CFR-2010-title30-vol2-sec256-20.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title30-vol2/pdf/CFR-2010-title30-vol2-sec256-20.pdf"><span>30 CFR 256.20 - <span class="hlt">Consideration</span> of coastal zone management program.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-07-01</p> <p>... 30 Mineral Resources 2 2010-07-01 2010-07-01 false <span class="hlt">Consideration</span> of coastal zone management....20 <span class="hlt">Consideration</span> of coastal zone management program. In the development of the leasing program, <span class="hlt">consideration</span> shall be given to the coastal zone management program being developed or administered by an...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4699645','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4699645"><span>Sampling Design Influences the <span class="hlt">Observed</span> Dominance of Culex tritaeniorhynchus: <span class="hlt">Considerations</span> for Future Studies of Japanese Encephalitis Virus Transmission</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Lord, Jennifer S.; Al-Amin, Hasan Mohammad; Chakma, Sumit; Alam, Mohammad Shafiul; Gurley, Emily S.; Pulliam, Juliet R. C.</p> <p>2016-01-01</p> <p>Mosquito sampling during Japanese encephalitis virus (JEV)-associated studies, particularly in India, has usually been conducted via aspirators or light traps to catch mosquitoes around cattle, which are dead-end hosts for JEV. High numbers of Culex tritaeniorhynchus, relative to other species, have often been caught during these studies. Less frequently, studies have involved sampling outdoor resting mosquitoes. We aimed to compare the relative abundance of mosquito species between these two previously used mosquito sampling methods. From September to December 2013 entomological surveys were undertaken in eight villages in a Japanese encephalitis (JE) endemic area of Bangladesh. Light traps were used to collect active mosquitoes in households, and resting boxes and a Bina Pani Das hop cage were used near oviposition sites to collect resting mosquitoes. Numbers of humans and domestic animals present in households where light traps were set were recorded. In five villages Cx. tritaeniorhynchus was more likely to be selected from light trap samples near hosts than resting collection samples near oviposition sites, according to log odds ratio tests. The opposite was true for Cx. pseudovishnui and Armigeres subalbatus, which can also transmit JEV. Culex tritaeniorhynchus constituted 59% of the mosquitoes sampled from households with cattle, 28% from households without cattle and 17% in resting collections. In contrast Cx. pseudovishnui constituted 5.4% of the sample from households with cattle, 16% from households with no cattle and 27% from resting collections, while Ar. subalbatus constituted 0.15%, 0.38%, and 8.4% of these samples respectively. These <span class="hlt">observations</span> may be due to <span class="hlt">differences</span> in timing of biting activity, host preference and host-seeking strategy rather than <span class="hlt">differences</span> in population density. We suggest that future studies aiming to implicate vector species in transmission of JEV should consider focusing catches around hosts able to transmit JEV. PMID</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26726881','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26726881"><span>Sampling Design Influences the <span class="hlt">Observed</span> Dominance of Culex tritaeniorhynchus: <span class="hlt">Considerations</span> for Future Studies of Japanese Encephalitis Virus Transmission.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lord, Jennifer S; Al-Amin, Hasan Mohammad; Chakma, Sumit; Alam, Mohammad Shafiul; Gurley, Emily S; Pulliam, Juliet R C</p> <p>2016-01-01</p> <p>Mosquito sampling during Japanese encephalitis virus (JEV)-associated studies, particularly in India, has usually been conducted via aspirators or light traps to catch mosquitoes around cattle, which are dead-end hosts for JEV. High numbers of Culex tritaeniorhynchus, relative to other species, have often been caught during these studies. Less frequently, studies have involved sampling outdoor resting mosquitoes. We aimed to compare the relative abundance of mosquito species between these two previously used mosquito sampling methods. From September to December 2013 entomological surveys were undertaken in eight villages in a Japanese encephalitis (JE) endemic area of Bangladesh. Light traps were used to collect active mosquitoes in households, and resting boxes and a Bina Pani Das hop cage were used near oviposition sites to collect resting mosquitoes. Numbers of humans and domestic animals present in households where light traps were set were recorded. In five villages Cx. tritaeniorhynchus was more likely to be selected from light trap samples near hosts than resting collection samples near oviposition sites, according to log odds ratio tests. The opposite was true for Cx. pseudovishnui and Armigeres subalbatus, which can also transmit JEV. Culex tritaeniorhynchus constituted 59% of the mosquitoes sampled from households with cattle, 28% from households without cattle and 17% in resting collections. In contrast Cx. pseudovishnui constituted 5.4% of the sample from households with cattle, 16% from households with no cattle and 27% from resting collections, while Ar. subalbatus constituted 0.15%, 0.38%, and 8.4% of these samples respectively. These <span class="hlt">observations</span> may be due to <span class="hlt">differences</span> in timing of biting activity, host preference and host-seeking strategy rather than <span class="hlt">differences</span> in population density. We suggest that future studies aiming to implicate vector species in transmission of JEV should consider focusing catches around hosts able to transmit JEV.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=gossip&pg=3&id=EJ786453','ERIC'); return false;" href="https://eric.ed.gov/?q=gossip&pg=3&id=EJ786453"><span>Perceptions of Friendship Quality and <span class="hlt">Observed</span> Behaviors with Friends: How Do Sociometrically Rejected, Average, and Popular Girls <span class="hlt">Differ</span>?</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Lansford, Jennifer E.; Putallaz, Martha; Grimes, Christina L.; Schiro-Osman, Kimberlea A.; Kupersmidt, Janis B.; Coie, John D.</p> <p>2006-01-01</p> <p>This study examined associations between sociometric status and friendship quality using <span class="hlt">observational</span> and questionnaire data from 139 fourth-grade girls and their friends. Multivariate analyses of covariance (controlling for ethnicity and socioeconomic status) showed that rejected girls and their friends did not <span class="hlt">differ</span> in their reported…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013CG.....51..339F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013CG.....51..339F"><span>A review of earth <span class="hlt">observation</span> using mobile personal communication devices</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ferster, Colin J.; Coops, Nicholas C.</p> <p>2013-02-01</p> <p>Earth <span class="hlt">observation</span> using mobile personal communication devices (MPCDs) is a recent advance with <span class="hlt">considerable</span> promise for acquiring important and timely measurements. Globally, over 5 billion people have access to mobile phones, with an increasing proportion having access to smartphones with capabilities such as a camera, microphone, global positioning system (GPS), data storage, and networked data transfer. Scientists can view these devices as embedded sensors with the potential to take measurements of the Earth's surface and processes. To advance the state of Earth <span class="hlt">observation</span> using MPCDs, scientists need to consider terms and concepts, from a broad range of disciplines including citizen science, image analysis, and computer vision. In this paper, as a result of our literature review, we identify a number of <span class="hlt">considerations</span> for Earth <span class="hlt">observation</span> using MPCDs such as methods of field collection, collecting measurements over broad areas, errors and biases, data processing, and accessibility of data. Developing effective frameworks for mobile data collection with public participation and strategies for minimizing bias, in combination with advancements in image processing techniques, will offer opportunities to collect Earth sensing data across a range of scales and perspectives, complimenting airborne and spaceborne remote sensing measurements.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20060021948','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20060021948"><span>Liquid Hydrogen Sensor <span class="hlt">Considerations</span> for Space Exploration</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Moran, Matthew E.</p> <p>2006-01-01</p> <p>The on-orbit management of liquid hydrogen planned for the return to the moon will introduce new <span class="hlt">considerations</span> not encountered in previous missions. This paper identifies critical liquid hydrogen sensing needs from the perspective of reliable on-orbit cryogenic fluid management, and contrasts the fundamental <span class="hlt">differences</span> in fluid and thermodynamic behavior for ground-based versus on-orbit conditions. Opportunities for advanced sensor development and implementation are explored in the context of critical Exploration Architecture operations such as on-orbit storage, docking, and trans-lunar injection burn. Key sensing needs relative to these operations are also examined, including: liquid/vapor detection, thermodynamic condition monitoring, mass gauging, and leak detection. Finally, operational aspects of an integrated system health management approach are discussed to highlight the potential impact on mission success.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title29-vol3/pdf/CFR-2010-title29-vol3-sec530-303.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title29-vol3/pdf/CFR-2010-title29-vol3-sec530-303.pdf"><span>29 CFR 530.303 - <span class="hlt">Considerations</span> in determining amounts.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-07-01</p> <p>... 29 Labor 3 2010-07-01 2010-07-01 false <span class="hlt">Considerations</span> in determining amounts. 530.303 Section 530... REGULATIONS EMPLOYMENT OF HOMEWORKERS IN CERTAIN INDUSTRIES Civil Money Penalties § 530.303 <span class="hlt">Considerations</span> in... representations; and (5) Exercise of due care. (b) An employer's financial inability to meet obligations under the...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title40-vol22/pdf/CFR-2010-title40-vol22-sec144-4.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title40-vol22/pdf/CFR-2010-title40-vol22-sec144-4.pdf"><span>40 CFR 144.4 - <span class="hlt">Considerations</span> under Federal law.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-07-01</p> <p>... 40 Protection of Environment 22 2010-07-01 2010-07-01 false <span class="hlt">Considerations</span> under Federal law. 144... (CONTINUED) UNDERGROUND INJECTION CONTROL PROGRAM General Provisions § 144.4 <span class="hlt">Considerations</span> under Federal law. The following is a list of Federal laws that may apply to the issuance of permits under these rules...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=226577&Lab=NHEERL&keyword=essential+AND+economic&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50','EPA-EIMS'); return false;" href="https://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=226577&Lab=NHEERL&keyword=essential+AND+economic&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50"><span>Regulatory <span class="hlt">Considerations</span> in Toxicological Neuropathology</span></a></p> <p><a target="_blank" href="http://oaspub.epa.gov/eims/query.page">EPA Science Inventory</a></p> <p></p> <p></p> <p>Pathological assessment of the nervous system is included in several US Environmental Protection Agency [US EPA or Agency] and Organization for Economic Cooperation and Development [OECD] testing guidelines for health effects of chemicals. A variety of <span class="hlt">considerations</span> are importan...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title30-vol2/pdf/CFR-2011-title30-vol2-sec256-20.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title30-vol2/pdf/CFR-2011-title30-vol2-sec256-20.pdf"><span>30 CFR 256.20 - <span class="hlt">Consideration</span> of coastal zone management program.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-07-01</p> <p>... 30 Mineral Resources 2 2011-07-01 2011-07-01 false <span class="hlt">Consideration</span> of coastal zone management... SHELF Oil and Gas Leasing Program § 256.20 <span class="hlt">Consideration</span> of coastal zone management program. In the development of the leasing program, <span class="hlt">consideration</span> shall be given to the coastal zone management program being...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22356464-characterizing-ultraviolet-infrared-observational-properties-galaxies-ii-features-attenuation-law','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22356464-characterizing-ultraviolet-infrared-observational-properties-galaxies-ii-features-attenuation-law"><span>Characterizing ultraviolet and infrared <span class="hlt">observational</span> properties for galaxies. II. Features of attenuation law</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Mao, Ye-Wei; Kong, Xu; Lin, Lin, E-mail: ywmao@pmo.ac.cn, E-mail: xkong@ustc.edu.cn, E-mail: linlin@shao.ac.cn</p> <p></p> <p>Variations in the attenuation law have a significant impact on <span class="hlt">observed</span> spectral energy distributions for galaxies. As one important <span class="hlt">observational</span> property for galaxies at ultraviolet and infrared wavelength bands, the correlation between infrared-to-ultraviolet luminosity ratio and ultraviolet color index (or ultraviolet spectral slope), i.e., the IRX-UV relation (or IRX-β relation), offered a widely used formula for correcting dust attenuation in galaxies, but the usability appears to be in doubt now because of <span class="hlt">considerable</span> dispersion in this relation found by many studies. In this paper, on the basis of spectral synthesis modeling and spatially resolved measurements of four nearby spiral galaxies,more » we provide an interpretation of the deviation in the IRX-UV relation with variations in the attenuation law. From both theoretical and <span class="hlt">observational</span> viewpoints, two components in the attenuation curve, the linear background and the 2175 Å bump, are suggested to be the parameters in addition to the stellar population age (addressed in the first paper of this series) in the IRX-UV function; <span class="hlt">different</span> features in the attenuation curve are diagnosed for the galaxies in our sample. Nevertheless, it is often difficult to ascertain the attenuation law for galaxies in actual <span class="hlt">observations</span>. Possible reasons for preventing the successful detection of the parameters in the attenuation curve are also discussed in this paper, including the degeneracy of the linear background and the 2175 Å bump in <span class="hlt">observational</span> channels, the requirement for young and dust-rich systems to study, and the difficulty in accurate estimates of dust attenuations at <span class="hlt">different</span> wavelength bands.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012AGUFM.H31K..02A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012AGUFM.H31K..02A"><span>The Inherent Uncertainty of In-Situ <span class="hlt">Observations</span> and its Implications for Modeling Evapotranspiration</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Alfieri, J. G.</p> <p>2012-12-01</p> <p>In-situ <span class="hlt">observations</span> are essential to a broad range of applications including the development, calibration, and validation of both the numerical and remote sensing-based models. For example, <span class="hlt">observational</span> data is requisite in order to evaluate the skill of these models both to represent the complex biogeophysical processes regulating evapotranspiration (ET) and to predict the magnitude of the moisture flux. As such, by propagating into these subsequent activities, any uncertainty or errors associated with the <span class="hlt">observational</span> data have the potential to adversely impact the accuracy and utility of these models. It is, therefore, critical that the factors driving measurement uncertainty are fully understood so that the steps can be taken to account for its effects and mitigate its impact on subsequent analyses. Field measurements of ET can be collected using a variety of techniques including eddy covariance (EC), lysimetry (LY), and scintillometry (SC). Each of these methods is underpinned by a unique set of theoretical <span class="hlt">considerations</span> and practical constraints; and, as a result, each method is susceptible to <span class="hlt">differing</span> types of systematic and random error. Since the uncertainty associated with the field measurements is predicated on how well numerous factors - for example, environmental conditions - adhere to those prescribed by the underlying assumptions, the quality of in-situ <span class="hlt">observations</span> collected via the <span class="hlt">differing</span> methods can vary significantly both over time and from site-to-site. Using data from both site studies and large field campaigns, such as IHOP_2002 and BEAREX08, the sources of uncertainty in field <span class="hlt">observations</span> will be discussed. The impact of measurement uncertainty on model validation will also be illustrated.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014ApJ...789...76M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014ApJ...789...76M"><span>Characterizing Ultraviolet and Infrared <span class="hlt">Observational</span> Properties for Galaxies. II. Features of Attenuation Law</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Mao, Ye-Wei; Kong, Xu; Lin, Lin</p> <p>2014-07-01</p> <p>Variations in the attenuation law have a significant impact on <span class="hlt">observed</span> spectral energy distributions for galaxies. As one important <span class="hlt">observational</span> property for galaxies at ultraviolet and infrared wavelength bands, the correlation between infrared-to-ultraviolet luminosity ratio and ultraviolet color index (or ultraviolet spectral slope), i.e., the IRX-UV relation (or IRX-β relation), offered a widely used formula for correcting dust attenuation in galaxies, but the usability appears to be in doubt now because of <span class="hlt">considerable</span> dispersion in this relation found by many studies. In this paper, on the basis of spectral synthesis modeling and spatially resolved measurements of four nearby spiral galaxies, we provide an interpretation of the deviation in the IRX-UV relation with variations in the attenuation law. From both theoretical and <span class="hlt">observational</span> viewpoints, two components in the attenuation curve, the linear background and the 2175 Å bump, are suggested to be the parameters in addition to the stellar population age (addressed in the first paper of this series) in the IRX-UV function; <span class="hlt">different</span> features in the attenuation curve are diagnosed for the galaxies in our sample. Nevertheless, it is often difficult to ascertain the attenuation law for galaxies in actual <span class="hlt">observations</span>. Possible reasons for preventing the successful detection of the parameters in the attenuation curve are also discussed in this paper, including the degeneracy of the linear background and the 2175 Å bump in <span class="hlt">observational</span> channels, the requirement for young and dust-rich systems to study, and the difficulty in accurate estimates of dust attenuations at <span class="hlt">different</span> wavelength bands.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.efficientwindows.org/design.php','SCIGOVWS'); return false;" href="http://www.efficientwindows.org/design.php"><span>Design <span class="hlt">Considerations</span> | Efficient Windows Collaborative</span></a></p> <p><a target="_blank" href="http://www.science.gov/aboutsearch.html">Science.gov Websites</a></p> <p></p> <p></p> <p>Foundry Foundry New Construction Windows Window Selection Tool Selection Process <em>Design</em> Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process <em>Design</em> Guidance Installation Understanding Windows Benefits <em>Design</em> <span class="hlt">Considerations</span> Measuring Performance Performance Standards</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5069136','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5069136"><span><span class="hlt">Considerations</span> and caveats in anti-virulence drug development</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Maura, Damien; Ballok, Alicia E.; Rahme, Laurence G.</p> <p>2016-01-01</p> <p>As antibiotic resistance remains a major public health threat, anti-virulence therapy research is gaining interest. Hundreds of potential anti-virulence compounds have been examined, but very few have made it to clinical trials and none have been approved. This review surveys the current anti-virulence research field with a focus on the highly resistant and deadly ESKAPE pathogens, especially Pseudomonas aeruginosa. We discuss timely <span class="hlt">considerations</span> and caveats in anti-virulence drug development, including target identification, administration, preclinical development, and metrics for success in clinical trials. Development of a defined pipeline for anti-virulence agents, which <span class="hlt">differs</span> in important ways from conventional antibiotics, is imperative for the future success of these critically needed drugs. PMID:27318551</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5644660','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5644660"><span>Equine Assisted Interventions (EAIs): Methodological <span class="hlt">Considerations</span> for Stress Assessment in Horses</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Cirulli, Francesca; Luzi, Fabio; Stefani, Annalisa; Toson, Marica; Odore, Rosangela; Farina, Luca</p> <p>2017-01-01</p> <p>Equine assisted interventions (EAIs) are recently facing an increasing popularity, and are characterized by a wide diversity of practices. However, information on the welfare of animals involved in this kind of activity is often lacking. Horses are highly susceptible to work stressors related to physical constraints and/or to the need to control emotions while interacting with humans. <span class="hlt">Considerations</span> of the emotional state of horses involved in EAIs have multiple valences: for the safety of humans and animals involved, for the quality and efficacy of interventions, as well as for ethical reasons. The aim of this unsystematic narrative review is to summarize the <span class="hlt">different</span> approaches used for the evaluation of horses’ stress responses, investigate their application in the context of EAIs, and discuss some methodological <span class="hlt">considerations</span> for researchers and practitioners involved in EAI. The sources of information are mostly based on electronic databases (i.e., Medline, Scopus and Google scholar), as well as on hand searches of the references of retrieved literature, and discussions with experts in the field. At present, a few studies have investigated horses’ stress responses during EAIs, and further studies are recommended, with the final aim to derive a reliable multidimensional method for assessing a horse’s reaction during therapeutic programs, ultimately helping professionals to better develop interventions by taking into <span class="hlt">consideration</span> the animal’s perspective. PMID:29056702</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_22 --> <div id="page_23" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="441"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5328849','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5328849"><span>Contextual Influences on Concordance between Maternal Report and Laboratory <span class="hlt">Observation</span> of Toddler Fear</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Kiel, Elizabeth J.; Hummel, Alexandra C.</p> <p>2016-01-01</p> <p>Emotion and temperament researchers have faced an enduring issue of how to best measure children’s tendencies to express specific emotions. Inconsistencies between laboratory <span class="hlt">observation</span> and parental report have made it challenging for researchers to determine the utility of these <span class="hlt">different</span> forms of measurement. The current study examined the effect of laboratory episode characteristics (i.e., threat-level of the episode, maternal involvement) on concordance between maternal report and laboratory <span class="hlt">observation</span> of toddler fear. The sample included 111 mother-toddler dyads who participated in a laboratory assessment when toddlers were approximately 24-months-old. Toddler fear was assessed both via maternal report and <span class="hlt">observation</span> from a number of laboratory episodes that varied in their level of threat and whether mothers were free or constrained in their involvement in the task. Results indicated that maternal report related to the <span class="hlt">observed</span> fear composites for low-threat, but not high-threat episodes. On the other hand, maternal involvement in the laboratory episodes did not moderate the relation between maternal report and laboratory <span class="hlt">observation</span> of fear. These results suggest that the threat-level of laboratory episodes designed to elicit fear, but not maternal involvement in these episodes, may be important to take into <span class="hlt">consideration</span> when assessing their relation to maternal report of fear and fearful temperament. PMID:27606826</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22781998','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22781998"><span>GPs' <span class="hlt">considerations</span> in multimorbidity management: a qualitative study.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Luijks, Hilde D; Loeffen, Maartje J W; Lagro-Janssen, Antoine L; van Weel, Chris; Lucassen, Peter L; Schermer, Tjard R</p> <p>2012-07-01</p> <p>Scientific evidence on how to manage multimorbidity is limited, but GPs have extensive practical experience with multimorbidity management. To explore GPs' <span class="hlt">considerations</span> and main objectives in the management of multimorbidity and to explore factors influencing their management of multimorbidity. Focus group study of Dutch GPs; with heterogeneity in characteristics such as sex, age and urbanisation. The moderator used an interview guide in conducting the interviews. Two researchers performed the analysis as an iterative process, based on verbatim transcripts and by applying the technique of constant comparative analysis. Data collection proceeded until saturation was reached. Five focus groups were conducted with 25 participating GPs. The main themes concerning multimorbidity management were individualisation, applying an integrated approach, medical <span class="hlt">considerations</span> placed in perspective, and sharing decision making and responsibility. A personal patient-doctor relationship was considered a major factor positively influencing the management of multimorbidity. Mental-health problems and interacting conditions were regarded as major barriers in this respect and participants experienced several practical problems. The concept of patient-centredness overarches the participants' main objectives. GPs' main objective in multimorbidity management is applying a patient-centred approach. This approach is welcomed since it counteracts some potential pitfalls of multimorbidity. Further research should include a similar design in a <span class="hlt">different</span> setting and should aim at developing best practice in multimorbidity management.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title31-vol2/pdf/CFR-2010-title31-vol2-part351-app-id880.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title31-vol2/pdf/CFR-2010-title31-vol2-part351-app-id880.pdf"><span>31 CFR Appendix to Part 351 - Tax <span class="hlt">Considerations</span></span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-07-01</p> <p>.... 351, App. A Appendix to Part 351—Tax <span class="hlt">Considerations</span> 1. What are some general tax <span class="hlt">considerations</span>... any other obligations purchased on a discount basis. (b) Changing methods. If you use the cash basis... primary owner. (d) The purchase of a Series EE savings bond as a gift may have gift tax consequences. ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title31-vol2/pdf/CFR-2011-title31-vol2-part351-app-id895.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title31-vol2/pdf/CFR-2011-title31-vol2-part351-app-id895.pdf"><span>31 CFR Appendix to Part 351 - Tax <span class="hlt">Considerations</span></span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-07-01</p> <p>.... 351, App. A Appendix to Part 351—Tax <span class="hlt">Considerations</span> 1. What are some general tax <span class="hlt">considerations</span>... any other obligations purchased on a discount basis. (b) Changing methods. If you use the cash basis... primary owner. (d) The purchase of a Series EE savings bond as a gift may have gift tax consequences. ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title5-vol1/pdf/CFR-2011-title5-vol1-sec332-407.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title5-vol1/pdf/CFR-2011-title5-vol1-sec332-407.pdf"><span>5 CFR 332.407 - Restriction of <span class="hlt">consideration</span> to one sex.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-01-01</p> <p>... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Restriction of <span class="hlt">consideration</span> to one sex... Restriction of <span class="hlt">consideration</span> to one sex. An appointing officer may not restrict his <span class="hlt">consideration</span> of eligibles... competitive service to one sex, except in unusual circumstances when OPM finds the action justified. [34 FR...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title5-vol1/pdf/CFR-2014-title5-vol1-sec332-407.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title5-vol1/pdf/CFR-2014-title5-vol1-sec332-407.pdf"><span>5 CFR 332.407 - Restriction of <span class="hlt">consideration</span> to one sex.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-01-01</p> <p>... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Restriction of <span class="hlt">consideration</span> to one sex... Restriction of <span class="hlt">consideration</span> to one sex. An appointing officer may not restrict his <span class="hlt">consideration</span> of eligibles... competitive service to one sex, except in unusual circumstances when OPM finds the action justified. [34 FR...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title5-vol1/pdf/CFR-2012-title5-vol1-sec332-407.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title5-vol1/pdf/CFR-2012-title5-vol1-sec332-407.pdf"><span>5 CFR 332.407 - Restriction of <span class="hlt">consideration</span> to one sex.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-01-01</p> <p>... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Restriction of <span class="hlt">consideration</span> to one sex... Restriction of <span class="hlt">consideration</span> to one sex. An appointing officer may not restrict his <span class="hlt">consideration</span> of eligibles... competitive service to one sex, except in unusual circumstances when OPM finds the action justified. [34 FR...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title5-vol1/pdf/CFR-2010-title5-vol1-sec332-407.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title5-vol1/pdf/CFR-2010-title5-vol1-sec332-407.pdf"><span>5 CFR 332.407 - Restriction of <span class="hlt">consideration</span> to one sex.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-01-01</p> <p>... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Restriction of <span class="hlt">consideration</span> to one sex... Restriction of <span class="hlt">consideration</span> to one sex. An appointing officer may not restrict his <span class="hlt">consideration</span> of eligibles... competitive service to one sex, except in unusual circumstances when OPM finds the action justified. [34 FR...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title5-vol1/pdf/CFR-2013-title5-vol1-sec332-407.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title5-vol1/pdf/CFR-2013-title5-vol1-sec332-407.pdf"><span>5 CFR 332.407 - Restriction of <span class="hlt">consideration</span> to one sex.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-01-01</p> <p>... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Restriction of <span class="hlt">consideration</span> to one sex... Restriction of <span class="hlt">consideration</span> to one sex. An appointing officer may not restrict his <span class="hlt">consideration</span> of eligibles... competitive service to one sex, except in unusual circumstances when OPM finds the action justified. [34 FR...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20080039561','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20080039561"><span>A Catalog of Galaxy Clusters <span class="hlt">Observed</span> by XMM-Newton</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Snowden, S. L.; Mushotzky, R. M.; Kuntz, K. D.; Davis, David S.</p> <p>2007-01-01</p> <p>Images and the radial profiles of the temperature, abundance, and brightness for 70 clusters of galaxies <span class="hlt">observed</span> by XMM-Newton are presented along with a detailed discussion of the data reduction and analysis methods, including background modeling, which were used in the processing. Proper <span class="hlt">consideration</span> of the various background components is vital to extend the reliable determination of cluster parameters to the largest possible cluster radii. The various components of the background including the quiescent particle background, cosmic diffuse emission, soft proton contamination, and solar wind charge exchange emission are discussed along with suggested means of their identification, filtering, and/or their modeling and subtraction. Every component is spectrally variable, sometimes significantly so, and all components except the cosmic background are temporally variable as well. The distributions of the events over the FOV vary between the components, and some distributions vary with energy. The scientific results from <span class="hlt">observations</span> of low surface brightness objects and the diffuse background itself can be strongly affected by these background components and therefore great care should be taken in their <span class="hlt">consideration</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20515315','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20515315"><span><span class="hlt">Considerations</span> in insulin delivery device selection.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Valentine, Virginia; Kruger, Davida F</p> <p>2010-06-01</p> <p>Recent guidelines from the American Diabetes Association and the European Association for the Study of Diabetes promote the use of insulin sooner rather than later in patients with type 2 diabetes to achieve goal range glucose control (< 7%) but remain silent on a recommendation for delivery system. Even though there is widespread consensus among experts and payers that people with type 2 diabetes should use insulin earlier to achieve tight control, it still remains an elusive goal. Benefits of pen-type delivery devices include accurate dosing, faster and easier setting of dose and injection times, and increased patient acceptance and adherence. Before healthcare professionals can recommend a delivery device, it is critical they understand not only the medication in the device but also the various features and benefits to the <span class="hlt">different</span> devices available and how those impact the patient. We will present <span class="hlt">considerations</span> to assist in making appropriate device selection, to optimize patient success.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28111497','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28111497"><span>Impacts of uncertainties in European gridded precipitation <span class="hlt">observations</span> on regional climate analysis.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Prein, Andreas F; Gobiet, Andreas</p> <p>2017-01-01</p> <p>Gridded precipitation data sets are frequently used to evaluate climate models or to remove model output biases. Although precipitation data are error prone due to the high spatio-temporal variability of precipitation and due to <span class="hlt">considerable</span> measurement errors, relatively few attempts have been made to account for <span class="hlt">observational</span> uncertainty in model evaluation or in bias correction studies. In this study, we compare three types of European daily data sets featuring two Pan-European data sets and a set that combines eight very high-resolution station-based regional data sets. Furthermore, we investigate seven widely used, larger scale global data sets. Our results demonstrate that the <span class="hlt">differences</span> between these data sets have the same magnitude as precipitation errors found in regional climate models. Therefore, including <span class="hlt">observational</span> uncertainties is essential for climate studies, climate model evaluation, and statistical post-processing. Following our results, we suggest the following guidelines for regional precipitation assessments. (1) Include multiple <span class="hlt">observational</span> data sets from <span class="hlt">different</span> sources (e.g. station, satellite, reanalysis based) to estimate <span class="hlt">observational</span> uncertainties. (2) Use data sets with high station densities to minimize the effect of precipitation undersampling (may induce about 60% error in data sparse regions). The information content of a gridded data set is mainly related to its underlying station density and not to its grid spacing. (3) Consider undercatch errors of up to 80% in high latitudes and mountainous regions. (4) Analyses of small-scale features and extremes are especially uncertain in gridded data sets. For higher confidence, use climate-mean and larger scale statistics. In conclusion, neglecting <span class="hlt">observational</span> uncertainties potentially misguides climate model development and can severely affect the results of climate change impact assessments.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5214405','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5214405"><span>Impacts of uncertainties in European gridded precipitation <span class="hlt">observations</span> on regional climate analysis</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Gobiet, Andreas</p> <p>2016-01-01</p> <p>ABSTRACT Gridded precipitation data sets are frequently used to evaluate climate models or to remove model output biases. Although precipitation data are error prone due to the high spatio‐temporal variability of precipitation and due to <span class="hlt">considerable</span> measurement errors, relatively few attempts have been made to account for <span class="hlt">observational</span> uncertainty in model evaluation or in bias correction studies. In this study, we compare three types of European daily data sets featuring two Pan‐European data sets and a set that combines eight very high‐resolution station‐based regional data sets. Furthermore, we investigate seven widely used, larger scale global data sets. Our results demonstrate that the <span class="hlt">differences</span> between these data sets have the same magnitude as precipitation errors found in regional climate models. Therefore, including <span class="hlt">observational</span> uncertainties is essential for climate studies, climate model evaluation, and statistical post‐processing. Following our results, we suggest the following guidelines for regional precipitation assessments. (1) Include multiple <span class="hlt">observational</span> data sets from <span class="hlt">different</span> sources (e.g. station, satellite, reanalysis based) to estimate <span class="hlt">observational</span> uncertainties. (2) Use data sets with high station densities to minimize the effect of precipitation undersampling (may induce about 60% error in data sparse regions). The information content of a gridded data set is mainly related to its underlying station density and not to its grid spacing. (3) Consider undercatch errors of up to 80% in high latitudes and mountainous regions. (4) Analyses of small‐scale features and extremes are especially uncertain in gridded data sets. For higher confidence, use climate‐mean and larger scale statistics. In conclusion, neglecting <span class="hlt">observational</span> uncertainties potentially misguides climate model development and can severely affect the results of climate change impact assessments. PMID:28111497</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19990014293','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19990014293"><span><span class="hlt">Considerations</span> for Multiprocessor Topologies</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Byrd, Gregory T.; Delagi, Bruce A.</p> <p>1987-01-01</p> <p>Choosing a multiprocessor interconnection topology may depend on high-level <span class="hlt">considerations</span>, such as the intended application domain and the expected number of processors. It certainly depends on low-level implementation details, such as packaging and communications protocols. The authors first use rough measures of cost and performance to characterize several topologies. They then examine how implementation details can affect the realizable performance of a topology.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28823697','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28823697"><span>Endoscopic <span class="hlt">observation</span> of <span class="hlt">different</span> repair patterns in human traumatic tympanic membrane perforations.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Huang, Peng; Zhang, Shujun; Gong, Xinhong; Wang, Xuesong; Lou, Zi-Han</p> <p>2017-08-03</p> <p>In the last decade, there has been an increasing use of biomaterial patches in the regeneration of traumatic tympanic membrane perforations. The major advantages of biomaterial patches are to provisionally restore the physiological function of the middle ear, thereby immediately improving ear symptoms, and act as a scaffold for epithelium migration. However, whether there are additional biological effects on eardrum regeneration is unclear for biological material patching in the clinic. This study evaluated the healing response for <span class="hlt">different</span> repair patterns in human traumatic tympanic membrane perforations by endoscopic <span class="hlt">observation</span>. In total, 114 patients with traumatic tympanic membrane perforations were allocated sequentially to two groups: the spontaneous healing group (n=57) and Gelfoam patch-treated group (n=57). The closure rate, closure time, and rate of otorrhea were compared between the groups at 3 months. Ultimately, 107 patients were analyzed in the two groups (52 patients in the spontaneous healing group vs. 55 patients in the Gelfoam patch-treated group). The overall closure rate at the end of the 3 month follow-up period was 90.4% in the spontaneous healing group and 94.5% in the Gelfoam patch-treated group; the <span class="hlt">difference</span> was not statistically significant (p>0.05). However, the total average closure time was significantly <span class="hlt">different</span> between the two groups (26.8±9.1 days in the spontaneous healing group vs. 14.7±9.1 days in the Gelfoam patch-treated group, p<0.01). In addition, the closure rate was not significantly <span class="hlt">different</span> between the spontaneous healing group and Gelfoam patch-treated group regardless of the perforation size. The closure time in the Gelfoam patch-treated group was significantly shorter than that in the spontaneous healing group regardless of the perforation size (small perforations: 7.1±1.6 days vs. 12.6±3.9, medium-sized perforations: 13.3±2.2 days vs. 21.8±4.2 days, and large perforations: 21.2±4.7 days vs. 38.4±5.7 days</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29024976','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29024976"><span>A conceptual framework for evaluating data suitability for <span class="hlt">observational</span> studies.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Shang, Ning; Weng, Chunhua; Hripcsak, George</p> <p>2017-09-08</p> <p>To contribute a conceptual framework for evaluating data suitability to satisfy the research needs of <span class="hlt">observational</span> studies. Suitability <span class="hlt">considerations</span> were derived from a systematic literature review on researchers' common data needs in <span class="hlt">observational</span> studies and a scoping review on frequent clinical database design <span class="hlt">considerations</span>, and were harmonized to construct a suitability conceptual framework using a bottom-up approach. The relationships among the suitability categories are explored from the perspective of 4 facets of data: intrinsic, contextual, representational, and accessible. A web-based national survey of domain experts was conducted to validate the framework. Data suitability for <span class="hlt">observational</span> studies hinges on the following key categories: Explicitness of Policy and Data Governance, Relevance, Availability of Descriptive Metadata and Provenance Documentation, Usability, and Quality. We describe 16 measures and 33 sub-measures. The survey uncovered the relevance of all categories, with a 5-point Likert importance score of 3.9 ± 1.0 for Explicitness of Policy and Data Governance, 4.1 ± 1.0 for Relevance, 3.9 ± 0.9 for Availability of Descriptive Metadata and Provenance Documentation, 4.2 ± 1.0 for Usability, and 4.0 ± 0.9 for Quality. The suitability framework evaluates a clinical data source's fitness for research use. Its construction reflects both researchers' points of view and data custodians' design features. The feedback from domain experts rated Usability, Relevance, and Quality categories as the most important <span class="hlt">considerations</span>. © The Author 2017. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21600395','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21600395"><span>Changes in the endopolyploidy pattern of <span class="hlt">different</span> tissues in diploid and tetraploid Phalaenopsis aphrodite subsp. formosana (Orchidaceae).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Chen, Wen-Huei; Tang, Ching-Yan; Lin, Tsai-Yun; Weng, Yuan-Chen; Kao, Yu-Lin</p> <p>2011-07-01</p> <p>Endopolyploidy is frequently <span class="hlt">observed</span> during development in plant species. Patterns of endopolyploidy are diverse in the various organs of <span class="hlt">different</span> plant species. However, little is known about the role of endopolyploidization and its significance in orchids. This study was undertaken to determine the extent of endopolyploidy in <span class="hlt">different</span> tissues of the diploid and tetraploid genotypes of Phalaenopsis aphrodite subsp. formosana and to examine the factors that contribute to increased ploidy levels. Endopolyploidy occurs in various tissues of diploid and tetraploid orchids, at <span class="hlt">different</span> developmental stages and under <span class="hlt">different</span> culture conditions, as determined by flow cytometry. In this study, <span class="hlt">different</span> patterns of endopolyploidy were <span class="hlt">observed</span> in parts of the protocorms, leaves, roots and flowers. Endopolyploidy was found in all tissues studied except the pollinia and the tetraploid ovaries. A higher degree of endopolyploidy was <span class="hlt">observed</span> in mature tissues compared to young tissues, greenhouse-grown plants compared to in vitro plants and diploid plants compared to tetraploid plants. We discuss the relationships between endopolyploidization and several factors related to plant growth, as well as some practical <span class="hlt">considerations</span> of these findings. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2100359','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2100359"><span>Commercial <span class="hlt">considerations</span> in tissue engineering</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Mansbridge, Jonathan</p> <p>2006-01-01</p> <p>Tissue engineering is a field with immense promise. Using the example of an early tissue-engineered skin implant, Dermagraft, factors involved in the successful commercial development of devices of this type are explored. Tissue engineering has to strike a balance between tissue culture, which is a resource-intensive activity, and business <span class="hlt">considerations</span> that are concerned with minimizing cost and maximizing customer convenience. Bioreactor design takes place in a highly regulated environment, so factors to be incorporated into the concept include not only tissue culture <span class="hlt">considerations</span> but also matters related to asepsis, scaleup, automation and ease of use by the final customer. Dermagraft is an allogeneic tissue. Stasis preservation, in this case cryopreservation, is essential in allogeneic tissue engineering, allowing sterility testing, inventory control and, in the case of Dermagraft, a cellular stress that may be important for hormesis following implantation. Although the use of allogeneic cells provides advantages in manufacturing under suitable conditions, it raises the spectre of immunological rejection. Such rejection has not been experienced with Dermagraft. Possible reasons for this and the vision of further application of allogeneic tissues are important <span class="hlt">considerations</span> in future tissue-engineered cellular devices. This review illustrates approaches that indicate some of the criteria that may provide a basis for further developments. Marketing is a further requirement for success, which entails understanding of the mechanism of action of the procedure, and is illustrated for Dermagraft. The success of a tissue-engineered product is dependent on many interacting operations, some discussed here, each of which must be performed simultaneously and well. PMID:17005024</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/17005024','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/17005024"><span>Commercial <span class="hlt">considerations</span> in tissue engineering.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Mansbridge, Jonathan</p> <p>2006-10-01</p> <p>Tissue engineering is a field with immense promise. Using the example of an early tissue-engineered skin implant, Dermagraft, factors involved in the successful commercial development of devices of this type are explored. Tissue engineering has to strike a balance between tissue culture, which is a resource-intensive activity, and business <span class="hlt">considerations</span> that are concerned with minimizing cost and maximizing customer convenience. Bioreactor design takes place in a highly regulated environment, so factors to be incorporated into the concept include not only tissue culture <span class="hlt">considerations</span> but also matters related to asepsis, scaleup, automation and ease of use by the final customer. Dermagraft is an allogeneic tissue. Stasis preservation, in this case cryopreservation, is essential in allogeneic tissue engineering, allowing sterility testing, inventory control and, in the case of Dermagraft, a cellular stress that may be important for hormesis following implantation. Although the use of allogeneic cells provides advantages in manufacturing under suitable conditions, it raises the spectre of immunological rejection. Such rejection has not been experienced with Dermagraft. Possible reasons for this and the vision of further application of allogeneic tissues are important <span class="hlt">considerations</span> in future tissue-engineered cellular devices. This review illustrates approaches that indicate some of the criteria that may provide a basis for further developments. Marketing is a further requirement for success, which entails understanding of the mechanism of action of the procedure, and is illustrated for Dermagraft. The success of a tissue-engineered product is dependent on many interacting operations, some discussed here, each of which must be performed simultaneously and well.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1989JGR....9418495A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1989JGR....9418495A"><span>The Sharav Cyclone: <span class="hlt">Observations</span> and some theoretical <span class="hlt">considerations</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Alpert, P.; Ziv, B.</p> <p>1989-12-01</p> <p>A special study of the Sharav Cyclones indicates that they are the result of large-scale weak baroclinicity, enhanced by vigorous boundary-layer baroclinicity between the North African coast and the Mediterranean. It is illustrated how the jet stream plays a major role in the vertical circulation in producing a complex cyclonic circulation dominated by at least three mechanisms: large-scale interior baroclinicity, boundary-layer baroclinicity, and jet stream related circulations. The main characteristics of the Sharav Cyclone (also called the Saharan Depression or Khamsin Depression) in the Mediterranean are reviewed. Unlike the cold winter cyclone, the Sharav Cyclone is a spring cyclone. Its tracks lie mainly along the North African coast and turn to the north near the southeastern Mediterranean. Its warm front is active and is sometimes associated with extremely high surface temperatures. Its cold front is shallow. The Sharav Cyclone moves eastward relatively fast, typically faster than 10 m s-1, and with a small speed variability. In general, there is an upper level trough to the west of the surface low and the surface horizontal scale is of the order of 500-1000 km. Finally, it is frequently associated with heavy dust/sand storms and low visibilities. Some of these features are illustrated in a case study of the April 28-30, 1986, cyclone. Vertical cross sections indicate a deep circulation associated with the exit region of an upper level jet. In addition to presenting evidence that the Sharav Cyclone is a deep tropospheric circulation, it is shown that the transverse indirect circulation at the exit region of the jet is a major component of its circulation. The classic two-level baroclinic model (Phillips, 1954) is applied. The effects of the major diabatic heating due to the sensible heat flux above the North African desert and the large north to south temperature gradients are incorporated through the thermal wind of the basic state. The model predicts the fast eastward motion, the relatively smaller horizontal scale and the fast growth rate. Furthermore, the model predicts an annual maximum growth rate in April and a secondary peak in October, which agrees with the frequency of occurrences of the Sharav Cyclones.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_23 --> <div id="page_24" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="461"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23966315','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23966315"><span>Satellite <span class="hlt">observed</span> widespread decline in Mongolian grasslands largely due to overgrazing.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hilker, Thomas; Natsagdorj, Enkhjargal; Waring, Richard H; Lyapustin, Alexei; Wang, Yujie</p> <p>2014-02-01</p> <p>The Mongolian Steppe is one of the largest remaining grassland ecosystems. Recent studies have reported widespread decline of vegetation across the steppe and about 70% of this ecosystem is now considered degraded. Among the scientific community there has been an active debate about whether the <span class="hlt">observed</span> degradation is related to climate, or over-grazing, or both. Here, we employ a new atmospheric correction and cloud screening algorithm (MAIAC) to investigate trends in satellite <span class="hlt">observed</span> vegetation phenology. We relate these trends to changes in climate and domestic animal populations. A series of harmonic functions is fitted to Moderate Resolution Imaging Spectroradiometer (MODIS) <span class="hlt">observed</span> phenological curves to quantify seasonal and inter-annual changes in vegetation. Our results show a widespread decline (of about 12% on average) in MODIS <span class="hlt">observed</span> normalized <span class="hlt">difference</span> vegetation index (NDVI) across the country but particularly in the transition zone between grassland and the Gobi desert, where recent decline was as much as 40% below the 2002 mean NDVI. While we found <span class="hlt">considerable</span> regional <span class="hlt">differences</span> in the causes of landscape degradation, about 80% of the decline in NDVI could be attributed to increase in livestock. Changes in precipitation were able to explain about 30% of degradation across the country as a whole but up to 50% in areas with denser vegetation cover (P < 0.05). Temperature changes, while significant, played only a minor role (r(2)  = 0.10, P < 0.05). Our results suggest that the cumulative effect of overgrazing is a primary contributor to the degradation of the Mongolian steppe and is at least partially responsible for desertification reported in previous studies. © 2013 John Wiley & Sons Ltd.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21568436','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21568436"><span>Bat noseleaf model: echolocation function, design <span class="hlt">considerations</span>, and experimental verification.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kuc, Roman</p> <p>2011-05-01</p> <p>This paper describes a possible bat noseleaf echolocation function that improves target elevation resolution. Bats with a protruding noseleaf can rotate the lancet to act as an acoustic mirror that reflects the nostril emission, modeled as a virtual nostril that produces a delayed emission. The cancellation of the nostril and virtual nostril components at a target produces a sharp spectral notch whose frequency location relates to target elevation. This notch can be <span class="hlt">observed</span> directly from the swept-frequency emission waveform, suggesting cochlear processing capabilities. Physical acoustic principles indicate the design <span class="hlt">considerations</span> and trade-offs that a bat can accomplish through noseleaf shape and emission characteristics. An experimental model verifies the analysis and exhibits an elevation versus notch frequency sensitivity of approximately 1°/kHz.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017ApPhA.123..721M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017ApPhA.123..721M"><span>Orientation of ripples induced by ultrafast laser pulses on copper in <span class="hlt">different</span> liquids</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Maragkaki, Stella; Elkalash, Abdallah; Gurevich, Evgeny L.</p> <p>2017-12-01</p> <p>Formation of laser-induced periodic surface structures (LIPSS or ripples) was studied on a metallic surface of polished copper using irradiation with multiple femtosecond laser pulses in <span class="hlt">different</span> environmental conditions (air, water, ethanol and methanol). Uniform LIPSS have been achieved by controlling the peak fluence and the overlapping rate. Ripples in both orientations, perpendicular and parallel to laser polarization, were <span class="hlt">observed</span> in all liquids simultaneously. The orientation of these ripples in the center of the ablated line was changing with the incident light intensity. For low intensities the orientation of the ripples is perpendicular to the laser polarization, whereas for high intensities it turns parallel to it without <span class="hlt">considerable</span> changes in the period. Multi-directional LIPSS formation was also <span class="hlt">observed</span> for moderate peak fluence in liquid environments.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27283785','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27283785"><span>Assisting Hand Assessment and Children's Hand-Use Experience Questionnaire -<span class="hlt">Observed</span> Versus Perceived Bimanual Performance in Children with Unilateral Cerebral Palsy.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ryll, Ulrike C; Bastiaenen, Carolien H G; Eliasson, Ann-Christin</p> <p>2017-05-01</p> <p>To explore the <span class="hlt">differences</span>, relationship, and extent of agreement between the Assisting Hand Assessment (AHA), measuring <span class="hlt">observed</span> ability to perform bimanual tasks, and the Children's Hand-Use Experience Questionnaire (CHEQ), assessing experienced bimanual performance. This study investigates a convenience sample of 34 children (16 girls) with unilateral cerebral palsy aged 6-18 years (mean 12.1, SD 3.9) in a cross-sectional design. The AHA and CHEQ subscales share 8-25% of their variance (R 2 ). Bland-Altman plots for AHA and all three CHEQ subscales indicate good average agreement, with a mean <span class="hlt">difference</span> approaching zero but large 95% confidence intervals. Limits of agreement were extremely wide, indicating <span class="hlt">considerable</span> disagreement between AHA and CHEQ subscales. AHA and CHEQ seem to measure <span class="hlt">different</span> though somewhat related constructs of bimanual performance. Results of this investigation reinforce the recommendation to use both instruments to obtain complementary information about bimanual performance including <span class="hlt">observed</span> and perceived performance of children with unilateral cerebral palsy.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2004ApJ...616..587S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2004ApJ...616..587S"><span><span class="hlt">Observational</span> Evidence for Small-Scale Mixture of Weak and Strong Fields in the Quiet Sun</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Socas-Navarro, H.; Lites, B. W.</p> <p>2004-11-01</p> <p>Three <span class="hlt">different</span> maps of the quiet Sun, <span class="hlt">observed</span> with the Advanced Stokes Polarimeter (ASP) and the Diffraction-Limited Stokes Polarimeter (DLSP), show evidence of strong (~=1700 G) and weak (<500 G) fields coexisting within the resolution element at both network and internetwork locations. The angular resolution of the <span class="hlt">observations</span> is of 1" (ASP) and 0.6" (DLSP). Even at the higher DLSP resolution, a significant fraction of the network magnetic patches harbor a mixture of strong and weak fields. Internetwork elements that exhibit kG fields when analyzed with a single-component atmosphere are also shown to harbor <span class="hlt">considerable</span> amounts of weak fields. Only those patches for which a single-component analysis yields weak fields do not show this mixture of field strengths. Finally, there is a larger fractional area of weak fields in the convective upflows than in the downflows.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27210290','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27210290"><span>Sex-related <span class="hlt">differences</span> in striatal dopaminergic system after traumatic brain injury.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Xu, Xiupeng; Cao, Shengwu; Chao, Honglu; Liu, Yinlong; Ji, Jing</p> <p>2016-06-01</p> <p>Several studies have demonstrated alterations in the dopamine (DA) system after traumatic brain injury (TBI). Additionally, the existence of significant sex-related <span class="hlt">differences</span> in the dopaminergic system has long been recognized. Accordingly, the purpose of the present study was to investigate whether TBI would differentially alter, in female and male mice, the expression and the function of the striatal vesicular monoamine transporter-2 (VMAT-2), an important DA transporter. After controlled cortical impact (CCI) injury, female mice showed significantly lower striatal DA concentrations and K(+)-evoked DA output. By contrast, no significant sex-related <span class="hlt">differences</span> were <span class="hlt">observed</span> in the mRNA and protein levels of striatal dopamine transporter (DAT) and VMAT-2 and the methamphetamine (MA)-evoked DA output. These results demonstrated clear sex-related <span class="hlt">differences</span> in striatal VMAT-2 function in response to TBI and suggested that female mice may be more sensitive to the TBI-induced inhibition of the VMAT-2 function, as indicated by the greater degree of deficits <span class="hlt">observed</span> when the VMAT-2 DA-storage function was inhibited by TBI. Moreover, the TBI-induced suppression of locomotion was more pronounced than female mice. Such findings highlight the need for sex-specific <span class="hlt">considerations</span> when examining <span class="hlt">differences</span> among brain injury conditions. Copyright © 2016 Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1333970-effects-time-varying-observation-errors-semi-empirical-sea-level-projections','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1333970-effects-time-varying-observation-errors-semi-empirical-sea-level-projections"><span>The effects of time-varying <span class="hlt">observation</span> errors on semi-empirical sea-level projections</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Ruckert, Kelsey L.; Guan, Yawen; Bakker, Alexander M. R.; ...</p> <p>2016-11-30</p> <p>Sea-level rise is a key driver of projected flooding risks. The design of strategies to manage these risks often hinges on projections that inform decision-makers about the surrounding uncertainties. Producing semi-empirical sea-level projections is difficult, for example, due to the complexity of the error structure of the <span class="hlt">observations</span>, such as time-varying (heteroskedastic) <span class="hlt">observation</span> errors and autocorrelation of the data-model residuals. This raises the question of how neglecting the error structure impacts hindcasts and projections. Here, we quantify this effect on sea-level projections and parameter distributions by using a simple semi-empirical sea-level model. Specifically, we compare three model-fitting methods: a frequentistmore » bootstrap as well as a Bayesian inversion with and without considering heteroskedastic residuals. All methods produce comparable hindcasts, but the parametric distributions and projections <span class="hlt">differ</span> <span class="hlt">considerably</span> based on methodological choices. In conclusion, our results show that the <span class="hlt">differences</span> based on the methodological choices are enhanced in the upper tail projections. For example, the Bayesian inversion accounting for heteroskedasticity increases the sea-level anomaly with a 1% probability of being equaled or exceeded in the year 2050 by about 34% and about 40% in the year 2100 compared to a frequentist bootstrap. These results indicate that neglecting known properties of the <span class="hlt">observation</span> errors and the data-model residuals can lead to low-biased sea-level projections.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/1333970-effects-time-varying-observation-errors-semi-empirical-sea-level-projections','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/1333970-effects-time-varying-observation-errors-semi-empirical-sea-level-projections"><span>The effects of time-varying <span class="hlt">observation</span> errors on semi-empirical sea-level projections</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Ruckert, Kelsey L.; Guan, Yawen; Bakker, Alexander M. R.</p> <p></p> <p>Sea-level rise is a key driver of projected flooding risks. The design of strategies to manage these risks often hinges on projections that inform decision-makers about the surrounding uncertainties. Producing semi-empirical sea-level projections is difficult, for example, due to the complexity of the error structure of the <span class="hlt">observations</span>, such as time-varying (heteroskedastic) <span class="hlt">observation</span> errors and autocorrelation of the data-model residuals. This raises the question of how neglecting the error structure impacts hindcasts and projections. Here, we quantify this effect on sea-level projections and parameter distributions by using a simple semi-empirical sea-level model. Specifically, we compare three model-fitting methods: a frequentistmore » bootstrap as well as a Bayesian inversion with and without considering heteroskedastic residuals. All methods produce comparable hindcasts, but the parametric distributions and projections <span class="hlt">differ</span> <span class="hlt">considerably</span> based on methodological choices. In conclusion, our results show that the <span class="hlt">differences</span> based on the methodological choices are enhanced in the upper tail projections. For example, the Bayesian inversion accounting for heteroskedasticity increases the sea-level anomaly with a 1% probability of being equaled or exceeded in the year 2050 by about 34% and about 40% in the year 2100 compared to a frequentist bootstrap. These results indicate that neglecting known properties of the <span class="hlt">observation</span> errors and the data-model residuals can lead to low-biased sea-level projections.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28226363','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28226363"><span>Coagulation Profile in Patients with <span class="hlt">Different</span> Etiologies for Cushing Syndrome: A Prospective <span class="hlt">Observational</span> Study.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tirosh, Amit; Lodish, Maya; Lyssikatos, Charalampos; Belyavskaya, Elena; Feelders, Richard A; Stratakis, Constantine A</p> <p>2017-05-01</p> <p>Previous studies reported a higher prevalence of venous-thromboembolic events among patients with Cushing disease (CD) compared to those with ACTH-independent Cushing syndrome (CS) from adrenal sources. The objective of the current study was to evaluate the coagulation profile of patients with CS from <span class="hlt">different</span> etiologies. A prospective <span class="hlt">observational</span> study was conducted at a clinical research center. The study included adult patients admitted for evaluation of suspected CS (n=85), that were divided into 3 groups: CD (n=22), ACTH-independent CS from an adrenal tumor/hyperplasia (adrenal CS, n=21), and a control group consisting of subjects with negative screening for CS (rule-out CS, n=42). Coagulation profiles were drawn before and 8.5±4.3 months after surgery (trans-sphenoidal or adrenalectomy, n=18), and included fibrinogen, Factor VIII (FVIII), von Willebrand factor antigen (vWF:Ag), plasminogen activator inhibitor-1 (PAI-1), antithrombin III (ATIII), Protein C (PC), Protein S (PS), α2-antiplasmin (α2AP), and aPTT measurements. Patients with CD had higher baseline mean cortisol levels, ATIII activity and vWF:Ag levels compared with adrenal CS. <span class="hlt">Differences</span> in ATIII activity and vWF:Ag levels remained even after controlling for BMI, and ATIII after also controlling for 24-h urinary free cortisol collections. Our study showed for the first time the <span class="hlt">differences</span> in coagulation profiles between various etiologies of CS. We assume that the higher cortisol burden among CD patients may explain the <span class="hlt">differences</span> found in the coagulation profile as well as the higher risk for VTE compared with primary adrenal CS patients. © Georg Thieme Verlag KG Stuttgart · New York.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1984SPIE..440..126S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1984SPIE..440..126S"><span>Some design <span class="hlt">considerations</span> for a synthetic aperture optical telescope array</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Scott, P. W.</p> <p>1984-01-01</p> <p>Several design <span class="hlt">considerations</span> inherent in the configuration of phased array transmission of multiwavelength laser beams are discussed. Attention is focused on the U.S.A.F. phased array (PHASAR) demonstration project, where problems have been encountered in dividing the beam(s), controlling the optical path <span class="hlt">differences</span> between subapertures, and expanding individual beams.A piston-driven path length adjustment mechanism has been selected, along with an active control system and proven components for stability maintenance. The necessity of developing broadband, high reflectivity low phase shift coatings for the system mirrors is stressed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4047781','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4047781"><span>Ethical <span class="hlt">considerations</span> of worksite health promotion: an exploration of stakeholders’ views</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2014-01-01</p> <p>Background Developing, implementing and evaluating worksite health promotion requires dealing with all stakeholders involved, such as employers, employees, occupational physicians, insurance companies, providers, labour unions and research and knowledge institutes. Although worksite health promotion is becoming more common, empirical research on ethical <span class="hlt">considerations</span> of worksite health promotion is scarce. Methods We explored the views of stakeholders involved in worksite health promotion in focus group discussions and we described the ethical <span class="hlt">considerations</span> that result from <span class="hlt">differences</span> between these views. The focus group discussions were organised per stakeholder group. Data were analysed according to the constant comparison method. Results Our analyses show that although the definition of occupational health is the same for all stakeholders, namely ‘being able to perform your job’, there seem to be important <span class="hlt">differences</span> in the views on what constitutes a risk factor to occupational health. According to the employees, risk factors to occupational health are prevailingly job-related. Labour unions agree with them, but other stakeholders, including the employer, particularly see employee-related issues such as lifestyle behaviour as risk factors to occupational health. The <span class="hlt">difference</span> in definition of occupational health risk factors translates into the same categorisation of worksite health promotion; employee-related activities and work-related activities. The <span class="hlt">difference</span> in conceptualisation of occupational health risk factors and worksite health promotion resonates in the way stakeholders understand ‘responsibility’ for lifestyle behaviour. Even though all stakeholders agree on whose responsibility lifestyle behaviour is, namely that of the employee, the meaning of ‘responsibility’ <span class="hlt">differs</span> between employees, and employers. For employees, responsibility means autonomy, while for employers and other stakeholders, responsibility equals duty. This</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24886339','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24886339"><span>Ethical <span class="hlt">considerations</span> of worksite health promotion: an exploration of stakeholders' views.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>van Berkel, Jantien; Meershoek, Agnes; Janssens, Rien M J P A; Boot, Cécile R L; Proper, Karin I; van der Beek, Allard J</p> <p>2014-05-16</p> <p>Developing, implementing and evaluating worksite health promotion requires dealing with all stakeholders involved, such as employers, employees, occupational physicians, insurance companies, providers, labour unions and research and knowledge institutes. Although worksite health promotion is becoming more common, empirical research on ethical <span class="hlt">considerations</span> of worksite health promotion is scarce. We explored the views of stakeholders involved in worksite health promotion in focus group discussions and we described the ethical <span class="hlt">considerations</span> that result from <span class="hlt">differences</span> between these views. The focus group discussions were organised per stakeholder group. Data were analysed according to the constant comparison method. Our analyses show that although the definition of occupational health is the same for all stakeholders, namely 'being able to perform your job', there seem to be important <span class="hlt">differences</span> in the views on what constitutes a risk factor to occupational health. According to the employees, risk factors to occupational health are prevailingly job-related. Labour unions agree with them, but other stakeholders, including the employer, particularly see employee-related issues such as lifestyle behaviour as risk factors to occupational health. The <span class="hlt">difference</span> in definition of occupational health risk factors translates into the same categorisation of worksite health promotion; employee-related activities and work-related activities. The <span class="hlt">difference</span> in conceptualisation of occupational health risk factors and worksite health promotion resonates in the way stakeholders understand 'responsibility' for lifestyle behaviour. Even though all stakeholders agree on whose responsibility lifestyle behaviour is, namely that of the employee, the meaning of 'responsibility' <span class="hlt">differs</span> between employees, and employers. For employees, responsibility means autonomy, while for employers and other stakeholders, responsibility equals duty. This <span class="hlt">difference</span> may in turn contribute to</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/17446909','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/17446909"><span>Geometrical <span class="hlt">considerations</span> in analyzing isotropic or anisotropic surface reflections.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Simonot, Lionel; Obein, Gael</p> <p>2007-05-10</p> <p>The bidirectional reflectance distribution function (BRDF) represents the evolution of the reflectance with the directions of incidence and <span class="hlt">observation</span>. Today BRDF measurements are increasingly applied and have become important to the study of the appearance of surfaces. The representation and the analysis of BRDF data are discussed, and the distortions caused by the traditional representation of the BRDF in a Fourier plane are pointed out and illustrated for two theoretical cases: an isotropic surface and a brushed surface. These <span class="hlt">considerations</span> will help characterize either the specular peak width of an isotropic rough surface or the main directions of the light scattered by an anisotropic rough surface without misinterpretations. Finally, what is believed to be a new space is suggested for the representation of the BRDF, which avoids the geometrical deformations and in numerous cases is more convenient for BRDF analysis.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19880024294&hterms=Lte&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D20%26Ntt%3DLte','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19880024294&hterms=Lte&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D20%26Ntt%3DLte"><span>LTE modeling of inhomogeneous chromospheric structure using high-resolution limb <span class="hlt">observations</span></span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Lindsey, C.</p> <p>1987-01-01</p> <p>The paper discusses <span class="hlt">considerations</span> relevant to LTE modeling of rough atmospheres. Particular attention is given to the application of recent high-resolution <span class="hlt">observations</span> of the solar limb in the far-infrared and radio continuum to the modeling of chromospheric spicules. It is explained how the continuum limb <span class="hlt">observations</span> can be combined with morphological knowledge of spicule structure to model the physical conditions in chromospheric spicules. This discussion forms the basis for a chromospheric model presented in a parallel publication based on <span class="hlt">observations</span> ranging from 100 microns to 2.6 mm.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20484859','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20484859"><span>Effects of strain <span class="hlt">differences</span> and vehicles on results of local lymph node assays.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Anzai, Takayuki; Ullmann, Ludwig G; Hayashi, Daisuke; Satoh, Tetsuo; Kumazawa, Takeshi; Sato, Keizo</p> <p>2010-01-01</p> <p>The Local Lymph Node Assay (LLNA) is now regarded as the worldwide standard. The analysis of accumulated LLNA data reveals that the animal strains and vehicles employed are likely to affect LLNA results. Here we show that an obvious strain <span class="hlt">difference</span> in the local lymph node response was <span class="hlt">observed</span> between DMSO-treated CBA/CaOlaHsd and CBA/CaHsdRcc mice. We also show that a vehicle <span class="hlt">difference</span> in the response was <span class="hlt">observed</span> when CBA/CaHsdRcc mice were exposed to 6 vehicles; 4:1 v/v acetone/olive oil (AOO), ethanol/water (70% EtOH), N,N-dimethylformamide (DMF), 2-butanone (BN), propylene glycol (PG), and dimethylsulfoxide (DMSO). The dpm/LN level was lowest in the 70% EtOH group and highest in the DMSO group. When alpha-hexylcinnamaldehyde (HCA) was used as a sensitizer for the LLNA, HCA was a weak sensitizer when AOO or DMSO was used as a vehicle, but a moderate sensitizer when the other 4 vehicles were used. This study showed that there are vehicle <span class="hlt">differences</span> in the local lymph node response (dpm/LN level) in the LLNA and that the sensitization potency of HCA may be classified in <span class="hlt">different</span> categories when using <span class="hlt">different</span> vehicles. This suggests that careful <span class="hlt">consideration</span> should be exercised in selecting a vehicle for the LLNA. A further comprehensive study will be needed to investigate why vehicle <span class="hlt">differences</span> are <span class="hlt">observed</span> in the LLNA.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28552191','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28552191"><span>Measuring geographical accessibility to rural and remote health care services: Challenges and <span class="hlt">considerations</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Shah, Tayyab Ikram; Milosavljevic, Stephan; Bath, Brenna</p> <p>2017-06-01</p> <p>This research is focused on methodological challenges and <span class="hlt">considerations</span> associated with the estimation of the geographical aspects of access to healthcare with a focus on rural and remote areas. With the assumption that GIS-based accessibility measures for rural healthcare services will vary across geographic units of analysis and estimation techniques, which could influence the interpretation of spatial access to rural healthcare services. Estimations of geographical accessibility depend on variations of the following three parameters: 1) quality of input data; 2) accessibility method; and 3) geographical area. This research investigated the spatial distributions of physiotherapists (PTs) in comparison to family physicians (FPs) across Saskatchewan, Canada. The three-steps floating catchment areas (3SFCA) method was applied to calculate the accessibility scores for both PT and FP services at two <span class="hlt">different</span> geographical units. A comparison of accessibility scores to simple healthcare provider-to-population ratios was also calculated. The results vary <span class="hlt">considerably</span> depending on the accessibility methods used and the choice of geographical area unit for measuring geographical accessibility for both FP and PT services. These findings raise intriguing questions regarding the nature and extent of technical issues and methodological <span class="hlt">considerations</span> that can affect GIS-based measures in health services research and planning. This study demonstrates how the selection of geographical areal units and <span class="hlt">different</span> methods for measuring geographical accessibility could affect the distribution of healthcare resources in rural areas. These methodological issues have implications for determining where there is reduced access that will ultimately impact health human resource priorities and policies. Copyright © 2017 Elsevier Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2002JOSAA..19.2085H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2002JOSAA..19.2085H"><span>First <span class="hlt">observation</span> of the fourth neutral polarization point in the atmosphere</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Horvath, Gabor; Bernath, Balazs; Suhai, Bence; Barta, Andras; Wehner, Rudiger</p> <p>2002-10-01</p> <p>In the clear sky there are three commonly known loci, the Arago, Babinet, and Brewster neutral points, where the skylight is unpolarized. These peculiar celestial points, bearing the names of their discoverers, have been the subject of many ground-based investigations, because their positions are sensitive indicators of the amount and type of atmospheric turbidity. According to theoretical <span class="hlt">considerations</span> and computer simulations, there should exist an additional neutral point approximately opposite to the Babinet point, which can be <span class="hlt">observed</span> only at higher altitudes in the air or space. Until now, this anonymous fourth neutral point has not been <span class="hlt">observed</span> during air- or space-borne polarimetric experiments and has been forgotten, in spite of the fact that the neutral points were a basic tool in atmospheric research for a century. Here, we report on the first <span class="hlt">observation</span> of this fourth neutral point from a hot air balloon. Using 180-field-of-view imaging polarimetry, we could <span class="hlt">observe</span> the fourth neutral point at 450, 550, and 650 nm from <span class="hlt">different</span> altitudes between 900 and 3500 m during and after sunrise at approximately 2240 below the anti-solar point along the anti-solar meridian, depending on the wavelength and solar elevation. We show that the fourth neutral point exists at the expected location and has characteristics similar to those of the Arago, Babinet, and Brewster points. We discuss why the fourth neutral point has not been <span class="hlt">observed</span> in previous air- or space-borne polarimetric experiments. 2002 Optical Society of America</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20090039496&hterms=greenhouse&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3Dgreenhouse','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20090039496&hterms=greenhouse&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3Dgreenhouse"><span>Opportunities for Coordinated <span class="hlt">Observations</span> of CO2 with the Orbiting Carbon Observatory (OCO) and Greenhouse Gases <span class="hlt">Observing</span> Satellite (GOSAT)</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Crisp, David</p> <p>2008-01-01</p> <p>The Orbiting Carbon Observatory (OCO) and the Greenhouse Gases <span class="hlt">Observing</span> Satellite (GOSAT) are the first two satellites designed to make global measurements of atmospheric carbon dioxide (CO2) with the precision and sampling needed identify and monitor surface sources and sinks of this important greenhouse gas. Because the operational phases of the OCO and GOSAT missions overlap in time, there are numerous opportunities for comparing and combining the data from these two satellites to improve our understanding of the natural processes and human activities that control the atmospheric CO2 and it variability over time. Opportunities for cross-calibration, cross-validation, and coordinated <span class="hlt">observations</span> that are currently under <span class="hlt">consideration</span> are summarized here.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA610100','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA610100"><span>Study of Integration <span class="hlt">Considerations</span> for Wireless Emergency Alerts</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2014-02-01</p> <p>affect adoption. Section 4 presents a list of overall <span class="hlt">considerations</span> for integrating a WEA messaging solution into an existing emergency management...in a product may negatively affect another de- sired quality. This section offers <span class="hlt">considerations</span> for balancing an organization’s priorities con... affect what emergency management agencies can, should, and must do with respect to conducting exercises and issuing alerts. More information about</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015JGRA..120.5805F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015JGRA..120.5805F"><span>Interhemispheric <span class="hlt">differences</span> in ionospheric convection: Cluster EDI <span class="hlt">observations</span> revisited</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Förster, M.; Haaland, S.</p> <p>2015-07-01</p> <p>The interaction between the interplanetary magnetic field and the geomagnetic field sets up a large-scale circulation in the magnetosphere. This circulation is also reflected in the magnetically connected ionosphere. In this paper, we present a study of ionospheric convection based on Cluster Electron Drift Instrument (EDI) satellite measurements covering both hemispheres and obtained over a full solar cycle. The results from this study show that average flow patterns and polar cap potentials for a given orientation of the interplanetary magnetic field can be very <span class="hlt">different</span> in the two hemispheres. In particular during southward directed interplanetary magnetic field conditions, and thus enhanced energy input from the solar wind, the measurements show that the southern polar cap has a higher cross polar cap potential. There are persistent north-south asymmetries, which cannot easily be explained by the influence of external drivers. These persistent asymmetries are primarily a result of the significant <span class="hlt">differences</span> in the strength and configuration of the geomagnetic field between the Northern and Southern Hemispheres. Since the ionosphere is magnetically connected to the magnetosphere, this <span class="hlt">difference</span> will also be reflected in the magnetosphere in the form of <span class="hlt">different</span> feedback from the two hemispheres. Consequently, local ionospheric conditions and the geomagnetic field configuration are important for north-south asymmetries in large regions of geospace.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_24 --> <div id="page_25" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active"><span>25</span></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="481"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013CQGra..30h9001H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013CQGra..30h9001H"><span>BOOK REVIEW: <span class="hlt">Observational</span> Cosmology <span class="hlt">Observational</span> Cosmology</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Howell, Dale Andrew</p> <p>2013-04-01</p> <p><span class="hlt">Observational</span> Cosmology by Stephen Serjeant fills a niche that was underserved in the textbook market: an up-to-date, thorough cosmology textbook focused on <span class="hlt">observations</span>, aimed at advanced undergraduates. Not everything about the book is perfect - some subjects get short shrift, in some cases jargon dominates, and there are too few exercises. Still, on the whole, the book is a welcome addition. For decades, the classic textbooks of cosmology have focused on theory. But for every Sunyaev-Zel'dovich effect there is a Butcher-Oemler effect; there are as many cosmological phenomena established by <span class="hlt">observations</span>, and only explained later by theory, as there were predicted by theory and confirmed by <span class="hlt">observations</span>. In fact, in the last decade, there has been an explosion of new cosmological findings driven by <span class="hlt">observations</span>. Some are so new that you won't find them mentioned in books just a few years old. So it is not just refreshing to see a book that reflects the new realities of cosmology, it is vital, if students are to truly stay up on a field that has widened in scope <span class="hlt">considerably</span>. <span class="hlt">Observational</span> Cosmology is filled with full-color images, and graphs from the latest experiments. How exciting it is that we live in an era where satellites and large experiments have gathered so much data to reveal astounding details about the origin of the universe and its evolution. To have all the latest data gathered together and explained in one book will be a revelation to students. In fact, at times it was to me. I've picked up modern cosmological knowledge through a patchwork of reading papers, going to colloquia, and serving on grant and telescope allocation panels. To go back and see them explained from square one, and summarized succinctly, filled in quite a few gaps in my own knowledge and corrected a few misconceptions I'd acquired along the way. To make room for all these graphs and <span class="hlt">observational</span> details, a few things had to be left out. For one, there are few derivations</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22272870-supernovae-seen-off-center-observers-local-void','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22272870-supernovae-seen-off-center-observers-local-void"><span>Supernovae as seen by off-center <span class="hlt">observers</span> in a local void</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Blomqvist, Michael; Mörtsell, Edvard, E-mail: michaelb@astro.su.se, E-mail: edvard@fysik.su.se</p> <p>2010-05-01</p> <p>Inhomogeneous universe models have been proposed as an alternative explanation for the apparent acceleration of the cosmic expansion that does not require dark energy. In the simplest class of inhomogeneous models, we live within a large, spherically symmetric void. Several studies have shown that such a model can be made consistent with many <span class="hlt">observations</span>, in particular the redshift-luminosity distance relation for type Ia supernovae, provided that the void is of Gpc size and that we live close to the center. Such a scenario challenges the Copernican principle that we do not occupy a special place in the universe. We usemore » the first-year Sloan Digital Sky Survey-II supernova search data set as well as the Constitution supernova data set to put constraints on the <span class="hlt">observer</span> position in void models, using the fact that off-center <span class="hlt">observers</span> will <span class="hlt">observe</span> an anisotropic universe. We first show that a spherically symmetric void can give good fits to the supernova data for an on-center <span class="hlt">observer</span>, but that the two data sets prefer very <span class="hlt">different</span> voids. We then continue to show that the <span class="hlt">observer</span> can be displaced at least fifteen percent of the void scale radius from the center and still give an acceptable fit to the supernova data. When combined with the <span class="hlt">observed</span> dipole anisotropy of the cosmic microwave background however, we find that the data compells the <span class="hlt">observer</span> to be located within about one percent of the void scale radius. Based on these results, we conclude that <span class="hlt">considerable</span> fine-tuning of our position within the void is needed to fit the supernova data, strongly disfavouring the model from a Copernican principle point of view.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24556241','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24556241"><span>Does neonatal pain management in intensive care units <span class="hlt">differ</span> between night and day? An <span class="hlt">observational</span> study.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Guedj, Romain; Danan, Claude; Daoud, Patrick; Zupan, Véronique; Renolleau, Sylvain; Zana, Elodie; Aizenfisz, Sophie; Lapillonne, Alexandre; de Saint Blanquat, Laure; Granier, Michèle; Durand, Philippe; Castela, Florence; Coursol, Anne; Hubert, Philippe; Cimerman, Patricia; Anand, K J S; Khoshnood, Babak; Carbajal, Ricardo</p> <p>2014-02-20</p> <p>To determine whether analgesic use for painful procedures performed in neonates in the neonatal intensive care unit (NICU) <span class="hlt">differs</span> during nights and days and during each of the 6 h period of the day. Conducted as part of the prospective <span class="hlt">observational</span> Epidemiology of Painful Procedures in Neonates study which was designed to collect in real time and around-the-clock bedside data on all painful or stressful procedures. 13 NICUs and paediatric intensive care units in the Paris Region, France. All 430 neonates admitted to the participating units during a 6-week period between September 2005 and January 2006. During the first 14 days of admission, data were collected on all painful procedures and analgesic therapy. The five most frequent procedures representing 38 012 of all 42 413 (90%) painful procedures were analysed. <span class="hlt">Observational</span> study. We compared the use of specific analgesic for procedures performed during each of the 6 h period of a day: morning (7:00 to 12:59), afternoon, early night and late night and during daytime (morning+afternoon) and night-time (early night+late night). 7724 of 38 012 (20.3%) painful procedures were carried out with a specific analgesic treatment. For morning, afternoon, early night and late night, respectively, the use of analgesic was 25.8%, 18.9%, 18.3% and 18%. The relative reduction of analgesia was 18.3%, p<0.01, between daytime and night-time and 28.8%, p<0.001, between morning and the rest of the day. Parental presence, nurses on 8 h shifts and written protocols for analgesia were associated with a decrease in this <span class="hlt">difference</span>. The substantial <span class="hlt">differences</span> in the use of analgesics around-the-clock may be questioned on quality of care grounds.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3931991','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3931991"><span>Does neonatal pain management in intensive care units <span class="hlt">differ</span> between night and day? An <span class="hlt">observational</span> study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Guedj, Romain; Danan, Claude; Daoud, Patrick; Zupan, Véronique; Renolleau, Sylvain; Zana, Elodie; Aizenfisz, Sophie; Lapillonne, Alexandre; de Saint Blanquat, Laure; Granier, Michèle; Durand, Philippe; Castela, Florence; Coursol, Anne; Hubert, Philippe; Cimerman, Patricia; Anand, K J S; Khoshnood, Babak; Carbajal, Ricardo</p> <p>2014-01-01</p> <p>Objective To determine whether analgesic use for painful procedures performed in neonates in the neonatal intensive care unit (NICU) <span class="hlt">differs</span> during nights and days and during each of the 6 h period of the day. Design Conducted as part of the prospective <span class="hlt">observational</span> Epidemiology of Painful Procedures in Neonates study which was designed to collect in real time and around-the-clock bedside data on all painful or stressful procedures. Setting 13 NICUs and paediatric intensive care units in the Paris Region, France. Participants All 430 neonates admitted to the participating units during a 6-week period between September 2005 and January 2006. Data collection During the first 14 days of admission, data were collected on all painful procedures and analgesic therapy. The five most frequent procedures representing 38 012 of all 42 413 (90%) painful procedures were analysed. Intervention <span class="hlt">Observational</span> study. Main outcome assessment We compared the use of specific analgesic for procedures performed during each of the 6 h period of a day: morning (7:00 to 12:59), afternoon, early night and late night and during daytime (morning+afternoon) and night-time (early night+late night). Results 7724 of 38 012 (20.3%) painful procedures were carried out with a specific analgesic treatment. For morning, afternoon, early night and late night, respectively, the use of analgesic was 25.8%, 18.9%, 18.3% and 18%. The relative reduction of analgesia was 18.3%, p<0.01, between daytime and night-time and 28.8%, p<0.001, between morning and the rest of the day. Parental presence, nurses on 8 h shifts and written protocols for analgesia were associated with a decrease in this <span class="hlt">difference</span>. Conclusions The substantial <span class="hlt">differences</span> in the use of analgesics around-the-clock may be questioned on quality of care grounds. PMID:24556241</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013E%26ES...16a2007A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013E%26ES...16a2007A"><span>Troubleshooting for the <span class="hlt">observed</span> problems in processing latex concentrate from natural resource</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Afreen, S.; Haque, K. R.; Huda, M. K.</p> <p>2013-06-01</p> <p>Natural latex has special importance in the rubber industry for manufacturing <span class="hlt">different</span> types of goods like gloves, balloons, male contraceptive and similar thin walled articles. This natural latex is much more sensitive a liquid to handle since it can easily become contaminated and thereby coagulated which makes it unfavourable for centrifuge and getting concentrate from it. Some other related measures also are included in <span class="hlt">consideration</span> during the processing of concentrate latex from the natural raw latex. The problems that are being faced in a concentrate latex processing plant can be categorized in <span class="hlt">different</span> groups like, problems related to the latex property, mechanical problems, electrical problems, handling and storage problems, transformation problems, problems related to environmental issues, etc. Among them, the most common and vital problems frequently <span class="hlt">observed</span> in a concentrate latex processing plant are discussed here with a view to finding the measures for solution which will help to maintain the latex property in any latex processing plant.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/12194327','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/12194327"><span>MCNP modelling of the wall effects <span class="hlt">observed</span> in tissue-equivalent proportional counters.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hoff, J L; Townsend, L W</p> <p>2002-01-01</p> <p>Tissue-equivalent proportional counters (TEPCs) utilise tissue-equivalent materials to depict homogeneous microscopic volumes of human tissue. Although both the walls and gas simulate the same medium, they respond to radiation <span class="hlt">differently</span>. Density <span class="hlt">differences</span> between the two materials cause distortions, or wall effects, in measurements, with the most dominant effect caused by delta rays. This study uses a Monte Carlo transport code, MCNP, to simulate the transport of secondary electrons within a TEPC. The Rudd model, a singly differential cross section with no dependence on electron direction, is used to describe the energy spectrum obtained by the impact of two iron beams on water. Based on the models used in this study, a wall-less TEPC had a higher lineal energy (keV.micron-1) as a function of impact parameter than a solid-wall TEPC for the iron beams under <span class="hlt">consideration</span>. An important conclusion of this study is that MCNP has the ability to model the wall effects <span class="hlt">observed</span> in TEPCs.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title48-vol5/pdf/CFR-2011-title48-vol5-sec733-103-73.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title48-vol5/pdf/CFR-2011-title48-vol5-sec733-103-73.pdf"><span>48 CFR 733.103-73 - Protests excluded from <span class="hlt">consideration</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... <span class="hlt">consideration</span>. 733.103-73 Section 733.103-73 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT GENERAL CONTRACTING REQUIREMENTS PROTESTS, DISPUTES, AND APPEALS Protests 733.103-73 Protests excluded from <span class="hlt">consideration</span>. (a) Contract administration. Disputes between a contractor and USAID are...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title48-vol5/pdf/CFR-2010-title48-vol5-sec733-103-73.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title48-vol5/pdf/CFR-2010-title48-vol5-sec733-103-73.pdf"><span>48 CFR 733.103-73 - Protests excluded from <span class="hlt">consideration</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... <span class="hlt">consideration</span>. 733.103-73 Section 733.103-73 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT GENERAL CONTRACTING REQUIREMENTS PROTESTS, DISPUTES, AND APPEALS Protests 733.103-73 Protests excluded from <span class="hlt">consideration</span>. (a) Contract administration. Disputes between a contractor and USAID are...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3498900','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3498900"><span>Fairness <span class="hlt">Considerations</span> When I Know More than You Do: Developmental Comparisons</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Overgaauw, Sandy; Güroğlu, Berna; Crone, Eveline A.</p> <p>2012-01-01</p> <p>The Ultimatum Game (UG) is a valuable paradigm to study fairness <span class="hlt">considerations</span>. Here, we tested developmental <span class="hlt">differences</span> between altruistic and strategic motivations in fairness <span class="hlt">considerations</span> using a version of the UG with hidden conditions. Participants were proposers and could divide coins between themselves and an anonymous other. Hidden information conditions involved division of coins where some coins were only visible to the participant (e.g., 8/2 condition where, from the total of 10 coins, 8 coins were visible to both players and 2 coins only visible to the proposer). In total, 22 young adults and 79 children between ages 8 and 13 played multiple one-shot versions of the UG with hidden conditions with anonymous others. Overall analyses confirmed validity of the task and showed that participants of all age groups had strategic intentions. Specific task analyses revealed that adults divided the coins equally in the standard UG conditions, but gave less to the second player in the hidden information conditions. The developmental comparisons revealed an age × condition interaction, such that adults and 10- to 12-year-old children differentiated between standard and hidden conditions more than 8- to 9-year-old children. These findings indicate that young children have a basic understanding of <span class="hlt">different</span> strategic motives, but that behavior of adults and older children is driven more by strategic intentions. PMID:23162494</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title48-vol3/pdf/CFR-2010-title48-vol3-sec244-202-2.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title48-vol3/pdf/CFR-2010-title48-vol3-sec244-202-2.pdf"><span>48 CFR 244.202-2 - <span class="hlt">Considerations</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT SUBCONTRACTING POLICIES AND PROCEDURES Consent to Subcontracts 244.202-2 <span class="hlt">Considerations</span>. (a) Where other than lowest price is the basis for subcontractor selection, has...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title36-vol3/pdf/CFR-2011-title36-vol3-sec1236-12.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title36-vol3/pdf/CFR-2011-title36-vol3-sec1236-12.pdf"><span>36 CFR 1236.12 - What other records management and preservation <span class="hlt">considerations</span> must be incorporated into the...</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-07-01</p> <p>... exchange of electronic documents between offices using <span class="hlt">different</span> software or operating systems. ... of electronic information systems? 1236.12 Section 1236.12 Parks, Forests, and Public Property... Management and Preservation <span class="hlt">Considerations</span> for Designing and Implementing Electronic Information Systems...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title36-vol3/pdf/CFR-2012-title36-vol3-sec1236-12.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title36-vol3/pdf/CFR-2012-title36-vol3-sec1236-12.pdf"><span>36 CFR 1236.12 - What other records management and preservation <span class="hlt">considerations</span> must be incorporated into the...</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-07-01</p> <p>... exchange of electronic documents between offices using <span class="hlt">different</span> software or operating systems. ... of electronic information systems? 1236.12 Section 1236.12 Parks, Forests, and Public Property... Management and Preservation <span class="hlt">Considerations</span> for Designing and Implementing Electronic Information Systems...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title36-vol3/pdf/CFR-2014-title36-vol3-sec1236-12.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title36-vol3/pdf/CFR-2014-title36-vol3-sec1236-12.pdf"><span>36 CFR 1236.12 - What other records management and preservation <span class="hlt">considerations</span> must be incorporated into the...</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-07-01</p> <p>... exchange of electronic documents between offices using <span class="hlt">different</span> software or operating systems. ... of electronic information systems? 1236.12 Section 1236.12 Parks, Forests, and Public Property... Management and Preservation <span class="hlt">Considerations</span> for Designing and Implementing Electronic Information Systems...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29119582','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29119582"><span>Emotions and assessment: <span class="hlt">considerations</span> for rater-based judgements of entrustment.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Gomez-Garibello, Carlos; Young, Meredith</p> <p>2018-03-01</p> <p>Assessment is subject to increasing scrutiny as medical education transitions towards a competency-based medical education (CBME) model. Traditional perspectives on the roles of assessment emphasise high-stakes, summative assessment, whereas CBME argues for formative assessment. Revisiting conceptualisations about the roles and formats of assessment in medical education provides opportunities to examine understandings and expectations of the assessment of learners. The act of the rater generating scores might be considered as an exclusively cognitive exercise; however, current literature has drawn attention to the notion of raters as measurement instruments, thereby attributing additional factors to their decision-making processes, such as social <span class="hlt">considerations</span> and intuition. However, the literature has not comprehensively examined the influence of raters' emotions during assessment. In this narrative review, we explore the influence of raters' emotions in the assessment of learners. We summarise existing literature that describes the role of emotions in assessment broadly, and rater-based assessment specifically, across a variety of fields. The literature related to emotions and assessment is examined from <span class="hlt">different</span> perspectives, including those of educational context, decision making and rater cognition. We use the concept of entrustable professional activities (EPAs) to contextualise a discussion of the ways in which raters' emotions may have meaningful impacts on the decisions they make in clinical settings. This review summarises findings from <span class="hlt">different</span> perspectives and identifies areas for <span class="hlt">consideration</span> for the role of emotion in rater-based assessment, and areas for future research. We identify and discuss three <span class="hlt">different</span> interpretations of the influence of raters' emotions during assessments: (i) emotions lead to biased decision making; (ii) emotions contribute random noise to assessment, and (iii) emotions constitute legitimate sources of information that</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16356028','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16356028"><span>Postcollision interaction in noble gas clusters: <span class="hlt">observation</span> of <span class="hlt">differences</span> in surface and bulk line shapes.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lindblad, A; Fink, R F; Bergersen, H; Lundwall, M; Rander, T; Feifel, R; Ohrwall, G; Tchaplyguine, M; Hergenhahn, U; Svensson, S; Björneholm, O</p> <p>2005-12-01</p> <p>The surface and bulk components of the x-ray photoelectron spectra of free noble gas clusters are shown to display <span class="hlt">differences</span> in the influence of postcollision interaction between the photoelectron and the Auger electron on the spectral line shape; the bulk component is <span class="hlt">observed</span> to be less affected than the surface and atomic parts of the spectra. A model for postcollision interaction in nonmetallic solids and clusters is also provided which takes the polarization screening into account. Core-level photoelectron spectra of Ar, Kr, and Xe have been recorded to verify the dependence of the postcollision interaction effect on the polarizability of the sample.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018PASA...35....8K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018PASA...35....8K"><span><span class="hlt">Observations</span> and Light Curve Solutions of Ultrashort-Period Eclipsing Binaries</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kjurkchieva, Diana P.; Dimitrov, Dinko P.; Ibryamov, Sunay I.; Vasileva, Doroteya L.</p> <p>2018-02-01</p> <p>Photometric <span class="hlt">observations</span> in V and I bands and low-dispersion spectra of 10 ultrashort-period binaries (NSVS 2175434, NSVS 2607629, NSVS 5038135, NSVS 8040227, NSVS 9747584, NSVS 4876238, ASAS 071829-0336.7, SWASP 074658.62+224448.5, NSVS 2729229, NSVS 10632802) are presented. One of them, NSVS 2729229, is newly discovered target. The results from modelling and analysis of our <span class="hlt">observations</span> revealed that (i) eight targets have overcontact configurations with <span class="hlt">considerable</span> fill-out factor (up to 0.5), while NSVS 4876238 and ASAS 0718-03 have almost contact configurations; (ii) NSVS 4876238 is rare ultrashort-period binary of detached type; (iii) all stellar components are late dwarfs; (iv) the temperature <span class="hlt">difference</span> of the components of each target does not exceed 400 K; (v) NSVS 2175434 and SWASP 074658.62 + 224448.5 exhibit total eclipses and their parameters could be assumed as well determined; (v) NSVS 2729229 shows emission in the Hα line. Masses, radii, and luminosities of the stellar components were estimated by the empirical relation `period, orbital axis' for short- and ultrashort-period binaries. We found linear relations mass-luminosity and mass-radius for the stellar components of our targets.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22048289','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22048289"><span>Generalization of color-<span class="hlt">difference</span> formulas for any illuminant and any <span class="hlt">observer</span> by assuming perfect color constancy in a color-vision model based on the OSA-UCS system.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Oleari, Claudio; Melgosa, Manuel; Huertas, Rafael</p> <p>2011-11-01</p> <p>The most widely used color-<span class="hlt">difference</span> formulas are based on color-<span class="hlt">difference</span> data obtained under D65 illumination or similar and for a 10° visual field; i.e., these formulas hold true for the CIE 1964 <span class="hlt">observer</span> adapted to D65 illuminant. This work considers the psychometric color-vision model based on the Optical Society of America-Uniform Color Scales (OSA-UCS) system previously published by the first author [J. Opt. Soc. Am. A 21, 677 (2004); Color Res. Appl. 30, 31 (2005)] with the additional hypothesis that complete illuminant adaptation with perfect color constancy exists in the visual evaluation of color <span class="hlt">differences</span>. In this way a computational procedure is defined for color conversion between <span class="hlt">different</span> illuminant adaptations, which is an alternative to the current chromatic adaptation transforms. This color conversion allows the passage between <span class="hlt">different</span> <span class="hlt">observers</span>, e.g., CIE 1964 and CIE 1931. An application of this color conversion is here made in the color-<span class="hlt">difference</span> evaluation for any <span class="hlt">observer</span> and in any illuminant adaptation: these transformations convert tristimulus values related to any <span class="hlt">observer</span> and illuminant adaptation to those related to the <span class="hlt">observer</span> and illuminant adaptation of the definition of the color-<span class="hlt">difference</span> formulas, i.e., to the CIE 1964 <span class="hlt">observer</span> adapted to the D65 illuminant, and then the known color-<span class="hlt">difference</span> formulas can be applied. The adaptations to the illuminants A, C, F11, D50, Planckian and daylight at any color temperature and for CIE 1931 and CIE 1964 <span class="hlt">observers</span> are considered as examples, and all the corresponding transformations are given for practical use.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25530456','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25530456"><span><span class="hlt">Observational</span> study of <span class="hlt">differences</span> in head position for high notes in famous classical and non-classical male singers.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Amarante Andrade, Pedro; Švec, Jan G</p> <p>2016-07-01</p> <p><span class="hlt">Differences</span> in classical and non-classical singing are due primarily to aesthetic style requirements. The head position can affect the sound quality. This study aimed at comparing the head position for famous classical and non-classical male singers performing high notes. Images of 39 Western classical and 34 non-classical male singers during live performances were obtained from YouTube. Ten raters evaluated the frontal rotational head position (depression versus elevation) and transverse head position (retraction versus protraction) visually using a visual analogue scale. The results showed a significant <span class="hlt">difference</span> for frontal rotational head position. Most non-classical singers in the sample elevated their heads for high notes while the classical singers were <span class="hlt">observed</span> to keep it around the neutral position. This <span class="hlt">difference</span> may be attributed to <span class="hlt">different</span> singing techniques and phonatory system adjustments utilized by each group.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26764160','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26764160"><span>267 Spanish Exomes Reveal Population-Specific <span class="hlt">Differences</span> in Disease-Related Genetic Variation.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Dopazo, Joaquín; Amadoz, Alicia; Bleda, Marta; Garcia-Alonso, Luz; Alemán, Alejandro; García-García, Francisco; Rodriguez, Juan A; Daub, Josephine T; Muntané, Gerard; Rueda, Antonio; Vela-Boza, Alicia; López-Domingo, Francisco J; Florido, Javier P; Arce, Pablo; Ruiz-Ferrer, Macarena; Méndez-Vidal, Cristina; Arnold, Todd E; Spleiss, Olivia; Alvarez-Tejado, Miguel; Navarro, Arcadi; Bhattacharya, Shomi S; Borrego, Salud; Santoyo-López, Javier; Antiñolo, Guillermo</p> <p>2016-05-01</p> <p>Recent results from large-scale genomic projects suggest that allele frequencies, which are highly relevant for medical purposes, <span class="hlt">differ</span> <span class="hlt">considerably</span> across <span class="hlt">different</span> populations. The need for a detailed catalog of local variability motivated the whole-exome sequencing of 267 unrelated individuals, representative of the healthy Spanish population. Like in other studies, a <span class="hlt">considerable</span> number of rare variants were found (almost one-third of the described variants). There were also relevant <span class="hlt">differences</span> in allelic frequencies in polymorphic variants, including ∼10,000 polymorphisms private to the Spanish population. The allelic frequencies of variants conferring susceptibility to complex diseases (including cancer, schizophrenia, Alzheimer disease, type 2 diabetes, and other pathologies) were overall similar to those of other populations. However, the trend is the opposite for variants linked to Mendelian and rare diseases (including several retinal degenerative dystrophies and cardiomyopathies) that show marked frequency <span class="hlt">differences</span> between populations. Interestingly, a correspondence between <span class="hlt">differences</span> in allelic frequencies and disease prevalence was found, highlighting the relevance of frequency <span class="hlt">differences</span> in disease risk. These <span class="hlt">differences</span> are also <span class="hlt">observed</span> in variants that disrupt known drug binding sites, suggesting an important role for local variability in population-specific drug resistances or adverse effects. We have made the Spanish population variant server web page that contains population frequency information for the complete list of 170,888 variant positions we found publicly available (http://spv.babelomics.org/), We show that it if fundamental to determine population-specific variant frequencies to distinguish real disease associations from population-specific polymorphisms. © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017EGUGA..19.9186K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017EGUGA..19.9186K"><span><span class="hlt">Observational</span> uncertainty and regional climate model evaluation: A pan-European perspective</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kotlarski, Sven; Szabó, Péter; Herrera, Sixto; Räty, Olle; Keuler, Klaus; Soares, Pedro M.; Cardoso, Rita M.; Bosshard, Thomas; Pagé, Christian; Boberg, Fredrik; Gutiérrez, José M.; Jaczewski, Adam; Kreienkamp, Frank; Liniger, Mark. A.; Lussana, Cristian; Szepszo, Gabriella</p> <p>2017-04-01</p> <p>Local and regional climate change assessments based on downscaling methods crucially depend on the existence of accurate and reliable <span class="hlt">observational</span> reference data. In dynamical downscaling via regional climate models (RCMs) <span class="hlt">observational</span> data can influence model development itself and, later on, model evaluation, parameter calibration and added value assessment. In empirical-statistical downscaling, <span class="hlt">observations</span> serve as predictand data and directly influence model calibration with corresponding effects on downscaled climate change projections. Focusing on the evaluation of RCMs, we here analyze the influence of uncertainties in <span class="hlt">observational</span> reference data on evaluation results in a well-defined performance assessment framework and on a European scale. For this purpose we employ three <span class="hlt">different</span> gridded <span class="hlt">observational</span> reference grids, namely (1) the well-established EOBS dataset (2) the recently developed EURO4M-MESAN regional re-analysis, and (3) several national high-resolution and quality-controlled gridded datasets that recently became available. In terms of climate models five reanalysis-driven experiments carried out by five <span class="hlt">different</span> RCMs within the EURO-CORDEX framework are used. Two variables (temperature and precipitation) and a range of evaluation metrics that reflect <span class="hlt">different</span> aspects of RCM performance are considered. We furthermore include an illustrative model ranking exercise and relate <span class="hlt">observational</span> spread to RCM spread. The results obtained indicate a varying influence of <span class="hlt">observational</span> uncertainty on model evaluation depending on the variable, the season, the region and the specific performance metric considered. Over most parts of the continent, the influence of the choice of the reference dataset for temperature is rather small for seasonal mean values and inter-annual variability. Here, model uncertainty (as measured by the spread between the five RCM simulations considered) is typically much larger than reference data uncertainty. 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