Sample records for observed high level

  1. High levels of reactive gaseous mercury observed at a high elevation research laboratory in the Rocky Mountains

    NASA Astrophysics Data System (ADS)

    Faïn, X.; Obrist, D.; Hallar, A. G.; McCubbin, I.; Rahn, T.

    2009-10-01

    The chemical cycling and spatiotemporal distribution of mercury in the troposphere is poorly understood. We measured gaseous elemental mercury (GEM), reactive gaseous mercury (RGM) and particulate mercury (HgP) along with carbon monoxide (CO), ozone (O3), aerosols, and meteorological variables at Storm Peak Laboratory at an elevation of 3200 m a.s.l., in Colorado, from 28 April to 1 July 2008. The mean mercury concentrations were 1.6 ng m-3 (GEM), 20 pg m-3 (RGM) and 9 pg m-3 (HgP). We observed eight events of strongly enhanced atmospheric RGM levels with maximum concentrations up to 137 pg m-3. RGM enhancement events lasted for long time periods of 2 to 6 days showing both enriched level during daytime and nighttime when other tracers (e.g., aerosols) showed different representations of boundary layer air and free tropospheric air. During seven of these events, RGM was inversely correlated to GEM (RGM/GEM regression slope ~-0.1), but did not exhibit correlations with ozone, carbon monoxide, or aerosol concentrations. Relative humidity was the dominant factor affecting RGM levels with high RGM levels always present whenever relative humidity was below 40 to 50%. We conclude that RGM enhancements observed at Storm Peak Laboratory were not induced by pollution events and were related to oxidation of tropospheric GEM. High RGM levels were not limited to upper tropospheric or stratospherically influenced air masses, indicating that entrainment processes and deep vertical mixing of free tropospheric air enriched in RGM may lead to high RGM levels throughout the troposphere and into the boundary layer over the Western United States. Based on backtrajectory analysis and a lack of mass balance between RGM and GEM, atmospheric production of RGM may also have occurred in some distance allowing for scavenging and/or deposition of RGM prior to reaching the laboratory. Our observations provide evidence that the tropospheric pool of mercury is frequently enriched in divalent

  2. High levels of reactive gaseous mercury observed at a high elevation research laboratory in the Rocky Mountains

    NASA Astrophysics Data System (ADS)

    Faïn, X.; Obrist, D.; Hallar, A. G.; McCubbin, I.; Rahn, T.

    2009-07-01

    The chemical cycling and spatiotemporal distribution of mercury in the troposphere is poorly understood. We measured gaseous elemental mercury (GEM), reactive gaseous mercury (RGM) and particulate mercury (HgP) along with CO, ozone, aerosols, and meteorological variables at Storm Peak Laboratory at an elevation of 3200 m a.s.l., in Colorado, from 28 April to 1 July 2008. The mean mercury concentrations were 1.6 ng m-3 (GEM), 20 pg m-3 (RGM) and 9 pg m-3 (HgP). We observed eight events of strongly enhanced atmospheric RGM levels with maximum concentrations up to 135 pg m-3. RGM enhancement events were unrelated to daytime/nighttime patterns and lasted for long time periods of 2 to 6 days. During seven of these events, RGM was inversely correlated to GEM (RGM/GEM regression slope ~ -0.1), but did not exhibit correlations with ozone, carbon monoxide, or aerosol concentrations. Relative humidity was the dominant factor affecting RGM levels with high RGM levels always present whenever relative humidity was below 40 to 50%. We conclude that RGM enhancements observed at Storm Peak Laboratory were not induced by pollution events and were related to oxidation of tropospheric GEM, but the mechanism remain unclear. Based on backtrajectory analysis and a lack of mass balance between RGM and GEM, we propose that in situ production of RGM may have occurred in some distance allowing for scavenging and/or deposition of some RGM prior to reaching the laboratory, and that GEM oxidation is an important tropospheric Hg sink. Our observations provide evidence that the tropospheric pool of mercury is frequently enriched in divalent mercury and that high RGM levels are not limited to the upper troposphere.

  3. System-level view of geospace dynamics: Challenges for high-latitude ground-based observations

    NASA Astrophysics Data System (ADS)

    Donovan, E.

    2014-12-01

    Increasingly, research programs including GEM, CEDAR, GEMSIS, GO Canada, and others are focusing on how geospace works as a system. Coupling sits at the heart of system level dynamics. In all cases, coupling is accomplished via fundamental processes such as reconnection and plasma waves, and can be between regions, energy ranges, species, scales, and energy reservoirs. Three views of geospace are required to attack system level questions. First, we must observe the fundamental processes that accomplish the coupling. This "observatory view" requires in situ measurements by satellite-borne instruments or remote sensing from powerful well-instrumented ground-based observatories organized around, for example, Incoherent Scatter Radars. Second, we need to see how this coupling is controlled and what it accomplishes. This demands quantitative observations of the system elements that are being coupled. This "multi-scale view" is accomplished by networks of ground-based instruments, and by global imaging from space. Third, if we take geospace as a whole, the system is too complicated, so at the top level we need time series of simple quantities such as indices that capture important aspects of the system level dynamics. This requires a "key parameter view" that is typically provided through indices such as AE and DsT. With the launch of MMS, and ongoing missions such as THEMIS, Cluster, Swarm, RBSP, and ePOP, we are entering a-once-in-a-lifetime epoch with a remarkable fleet of satellites probing processes at key regions throughout geospace, so the observatory view is secure. With a few exceptions, our key parameter view provides what we need. The multi-scale view, however, is compromised by space/time scales that are important but under-sampled, combined extent of coverage and resolution that falls short of what we need, and inadequate conjugate observations. In this talk, I present an overview of what we need for taking system level research to its next level, and how

  4. Evaluation of high-level clouds in cloud resolving model simulations with ARM and KWAJEX observations

    DOE PAGES

    Liu, Zheng; Muhlbauer, Andreas; Ackerman, Thomas

    2015-11-05

    In this paper, we evaluate high-level clouds in a cloud resolving model during two convective cases, ARM9707 and KWAJEX. The simulated joint histograms of cloud occurrence and radar reflectivity compare well with cloud radar and satellite observations when using a two-moment microphysics scheme. However, simulations performed with a single moment microphysical scheme exhibit low biases of approximately 20 dB. During convective events, two-moment microphysical overestimate the amount of high-level cloud and one-moment microphysics precipitate too readily and underestimate the amount and height of high-level cloud. For ARM9707, persistent large positive biases in high-level cloud are found, which are not sensitivemore » to changes in ice particle fall velocity and ice nuclei number concentration in the two-moment microphysics. These biases are caused by biases in large-scale forcing and maintained by the periodic lateral boundary conditions. The combined effects include significant biases in high-level cloud amount, radiation, and high sensitivity of cloud amount to nudging time scale in both convective cases. The high sensitivity of high-level cloud amount to the thermodynamic nudging time scale suggests that thermodynamic nudging can be a powerful ‘‘tuning’’ parameter for the simulated cloud and radiation but should be applied with caution. The role of the periodic lateral boundary conditions in reinforcing the biases in cloud and radiation suggests that reducing the uncertainty in the large-scale forcing in high levels is important for similar convective cases and has far reaching implications for simulating high-level clouds in super-parameterized global climate models such as the multiscale modeling framework.« less

  5. The HST Frontier Fields: Complete Observations and High-Level Science Data Products for All 6 Clusters

    NASA Astrophysics Data System (ADS)

    Koekemoer, Anton M.; Mack, Jennifer; Lotz, Jennifer M.; Borncamp, David; Khandrika, Harish G.; Lucas, Ray A.; Martlin, Catherine; Martlin, Catherine; Porterfield, Blair; Sunnquist, Ben; Anderson, Jay; Avila, Roberto J.; Barker, Elizabeth A.; Grogin, Norman A.; Gunning, Heather C.; Hilbert, Bryan; Ogaz, Sara; Robberto, Massimo; Sembach, Kenneth; Flanagan, Kathryn; Mountain, Matt; HST Frontier Fields Team

    2017-06-01

    The Hubble Space Telescope Frontier Fields program is a large Director's Discretionary program of 840 orbits, to obtain ultra-deep observations of six strong lensing clusters of galaxies, together with parallel deep blank fields, making use of the strong lensing amplification by these clusters of distant background galaxies to detect the faintest galaxies currently observable in the high-redshift universe. The entire program has now completed successfully for all 6 clusters, namely Abell 2744, Abell S1063, Abell 370, MACS J0416.1-2403, MACS J0717.5+3745 and MACS J1149.5+2223,. Each of these was observed over two epochs, to a total depth of 140 orbits on the main cluster and an associated parallel field, obtaining images in ACS (F435W, F606W, F814W) and WFC3/IR (F105W, F125W, F140W, F160W) on both the main cluster and the parallel field in all cases. Full sets of high-level science products have been generated for all these clusters by the team at STScI, including cumulative-depth data releases during each epoch, as well as full-depth releases after the completion of each epoch. These products include all the full-depth distortion-corrected drizzled mosaics and associated products for each cluster, which are science-ready to facilitate the construction of lensing models as well as enabling a wide range of other science projects. Many improvements beyond default calibration for ACS and WFC3/IR are implemented in these data products, including corrections for persistence, time-variable sky, and low-level dark current residuals, as well as improvements in astrometric alignment to achieve milliarcsecond-level accuracy. The full set of resulting high-level science products and mosaics are publicly delivered to the community via the Mikulski Archive for Space Telescopes (MAST) to enable the widest scientific use of these data, as well as ensuring a public legacy dataset of the highest possible quality that is of lasting value to the entire community.

  6. Observations of the high vibrational levels of the B ' ' B ¯ 1 Σu + state of H2

    NASA Astrophysics Data System (ADS)

    Chartrand, A. M.; Duan, W.; Ekey, R. C.; McCormack, E. F.

    2016-01-01

    Double-resonance laser spectroscopy via the E F 1 Σg + , v ' = 6 , J ' = 0 -2 state was used to probe the high vibrational levels of the B ' ' B ¯ 1 Σu + state of molecular hydrogen. Resonantly enhanced multiphoton ionization spectra were recorded by detecting ion production as a function of energy using a time of flight mass spectrometer. New measurements of energies for the v = 51-66 levels for the B ' ' B ¯ state of H2 are reported, which, taken with previous results, span the v = 46-69 vibrational levels. Results for energy levels are compared to theoretical close-coupled calculations [L. Wolniewicz, T. Orlikowski, and G. Staszewska, J. Mol. Spectrosc. 238, 118-126 (2006)]. The average difference between the 84 measured energies and calculated energies is -3.8 cm-1 with a standard deviation of 5.3 cm-1. This level of agreement showcases the success of the theoretical calculations in accounting for the strong rovibronic mixing of the 1 Σu + and 1 Πu + states. Due to the ion-pair character of the outer well, the observed energies of the vibrational levels below the third dissociation limit smoothly connect with previously observed energies of ion-pair states above this limit. The results provide an opportunity for testing a heavy Rydberg multi-channel quantum defect analysis of the high vibrational states below the third dissociation limit.

  7. High-molecular-weight adiponectin levels in healthy, community-dwelling, elderly Japanese volunteers: a 5-year prospective observational study.

    PubMed

    Otsuka, Hiromasa; Yanai, Mitsuru; Kobayashi, Hiroki; Haketa, Akira; Hara, Motohiko; Sugama, Kaoru; Kato, Kimitoshi; Soma, Masayoshi

    2017-10-19

    Serum adiponectin levels are associated with frailty and cardiovascular diseases. Longitudinal changes in adiponectin levels might enhance our understanding of age-related conditions and diseases. This prospective observational study aimed to: (1) elucidate age-related changes in high-molecular-weight (HMW) adiponectin levels; and (2) identify variables predictive of elevated HMW adiponectin levels and the association with well-known adiponectin single-nucleotide polymorphisms (SNPs) in healthy, elderly Japanese participants. Healthy elderly volunteers (n = 196; 55 men and 141 women; median age 72.0 years; range 69.0-75.0 years) underwent anthropometric and physical function measurements, as well as laboratory tests at baseline and the 5-year follow-up. HMW adiponectin levels were significantly higher in women than in men (8.4, 5.3-11.9 vs. 5.7, 3.1-9.0 μg/mL; p < 0.001) at baseline and decreased significantly at follow-up in women (7.7, 4.8-11.2 μg/mL; p < 0.001), but not in men. In the multiple regression analysis, high-density lipoprotein cholesterol levels and body weight were independent predictors of HMW adiponectin levels. The rate of change in HMW adiponectin levels was inversely correlated with the rates of change in body weight, body mass index, and knee leg extension strengths, and positively correlated with rates of change in high-density lipoprotein cholesterol and one-leg standing time. There were no significant differences in HMW adiponectin levels among SNPs. Decreasing HMW adiponectin levels might lead to an increased risk of cardiovascular diseases in elderly women. HMW adiponectin levels significantly decreased over a 5-year period in community-dwelling elderly Japanese women.

  8. Wii mote as hydrological sensor: observation of water level fluctuations

    NASA Astrophysics Data System (ADS)

    Luxemburg, W.; Hut, R.; Weijs, S.; Hegnauer, M.

    2009-12-01

    The input device of the Nintendo Wii, the Wii-mote offers scientist a multitude of cheap, high quality sensors; ideal for proof of concept testing. For a specific application, i.e. the water level fluctuation in a floating evaporation pan the Wii-mote was tested as the observing device. It is shown that the controller can observe movements with high enough temporal and spatial resolution of up to 4 infrared LED’s to describe water level movements. Floating pans positioned in lakes and reservoirs better represent open water evaporation than evaporation pans installed on land. On the other hand performing water level measurements in a floating pan is more complicated due to movement of the pan and wave activities in the pan. The Wii-mote was mounted on the side of a standard class A-pan and a float was placed in the middle of the pan, with 4 LED’s on top moving along a fixed bar. The information that the Wii-mote wirelessly sends by blue tooth was captured on a laptop. With a MATLAB routine this data was converted into movement of the LED’s relatively to the controller. The observations show that wave activities are nicely captured with a typical spatial resolution smaller than 0.1 mm in our set-up and a temporal resolution of maximum 100 Hz. A frequency domain filter was applied to the observed datasets to obtain average water levels. In our laboratory setting the pan was placed in a large basin with a wave generator. A constant, but small, rate of water was added to the evaporation pan. The average pan levels from the filtered datasets showed systematically lower levels compared to the level without any wave activities. This is a typical effect of waves that occur in shallow basins. However, the added water with rates up to 5 mm/hour were clearly recognized in the filtered datasets which indicates that the Wii-mote is very well capable as a sensor for water level observations.

  9. Evolution of high-level resistance during low-level antibiotic exposure.

    PubMed

    Wistrand-Yuen, Erik; Knopp, Michael; Hjort, Karin; Koskiniemi, Sanna; Berg, Otto G; Andersson, Dan I

    2018-04-23

    It has become increasingly clear that low levels of antibiotics present in many environments can select for resistant bacteria, yet the evolutionary pathways for resistance development during exposure to low amounts of antibiotics remain poorly defined. Here we show that Salmonella enterica exposed to sub-MIC levels of streptomycin evolved high-level resistance via novel mechanisms that are different from those observed during lethal selections. During lethal selection only rpsL mutations are found, whereas at sub-MIC selection resistance is generated by several small-effect resistance mutations that combined confer high-level resistance via three different mechanisms: (i) alteration of the ribosomal RNA target (gidB mutations), (ii) reduction in aminoglycoside uptake (cyoB, nuoG, and trkH mutations), and (iii) induction of the aminoglycoside-modifying enzyme AadA (znuA mutations). These results demonstrate how the strength of the selective pressure influences evolutionary trajectories and that even weak selective pressures can cause evolution of high-level resistance.

  10. Summertime observations of elevated levels of ultrafine particles in the high Arctic marine boundary layer

    NASA Astrophysics Data System (ADS)

    Burkart, Julia; Willis, Megan D.; Bozem, Heiko; Thomas, Jennie L.; Law, Kathy; Hoor, Peter; Aliabadi, Amir A.; Köllner, Franziska; Schneider, Johannes; Herber, Andreas; Abbatt, Jonathan P. D.; Leaitch, W. Richard

    2017-05-01

    Motivated by increasing levels of open ocean in the Arctic summer and the lack of prior altitude-resolved studies, extensive aerosol measurements were made during 11 flights of the NETCARE July 2014 airborne campaign from Resolute Bay, Nunavut. Flights included vertical profiles (60 to 3000 m above ground level) over open ocean, fast ice, and boundary layer clouds and fogs. A general conclusion, from observations of particle numbers between 5 and 20 nm in diameter (N5 - 20), is that ultrafine particle formation occurs readily in the Canadian high Arctic marine boundary layer, especially just above ocean and clouds, reaching values of a few thousand particles cm-3. By contrast, ultrafine particle concentrations are much lower in the free troposphere. Elevated levels of larger particles (for example, from 20 to 40 nm in size, N20 - 40) are sometimes associated with high N5 - 20, especially over low clouds, suggestive of aerosol growth. The number densities of particles greater than 40 nm in diameter (N > 40) are relatively depleted at the lowest altitudes, indicative of depositional processes that will lower the condensation sink and promote new particle formation. The number of cloud condensation nuclei (CCN; measured at 0.6 % supersaturation) are positively correlated with the numbers of small particles (down to roughly 30 nm), indicating that some fraction of these newly formed particles are capable of being involved in cloud activation. Given that the summertime marine Arctic is a biologically active region, it is important to better establish the links between emissions from the ocean and the formation and growth of ultrafine particles within this rapidly changing environment.

  11. High-Energy Particle Showers Observed at Ground Level in Coincidence with Downward Lightning Leaders at the Telescope Array Observatory

    NASA Astrophysics Data System (ADS)

    Belz, John; Abbasi, Rasha; Le Von, Ryan; Krehbiel, Paul; Remington, Jackson; Rison, William

    Terrestrial Gamma Ray Flashes (TGFs) detected by satellite observations have been shown to be generated by upward propagating negative leaders at altitudes of about 10 to 12 km above Mean Sea Level (MSL), and have durations ranging between a few hundred microseconds and a few milliseconds. The Telescope Array Cosmic Ray observatory, designed to observe air showers induced by ultra high energy cosmic rays, includes a surface scintillator detector (SD) covering approximately 700 square kilometers on a 1.2 km grid. Following the observation of anomalous SD triggers correlated with local lightning activity, a Lightning Mapping Array (LMA) and slow electric field antenna were installed at the TA site in order to characterize the lightning associated with these anomalous triggers. In this talk, we present evidence that the anomalous triggers are produced during the initial breakdown phase of fast, downward propagating, negative leaders above the detectors which produced the triggers. The durations of the high energy radiation are a few hundred microseconds, similar to satellite observations of TGFs. The triggers were produced within a few hundred microseconds of the initiation of the leaders, when the leaders were at an altitude of about 3 to 4 km MSL. The TA scintillation detectors are not optimized for gamma ray detection, however we present the results of simulations demonstrating that the fluxes observed are consistent with this picture. We conclude that the anomalous triggers observed by TA are clearly due to high energy radiation produced by the fast downward propagating negative leaders, and are probably downward-directed TGFs.

  12. Pan-Eurasian experiment (PEEX) establishing a process towards high level Pan-Eurasian atmosphere-ecosystem observation networks

    NASA Astrophysics Data System (ADS)

    Lappalainen, Hanna K.; Petäjä, Tuukka; Zaytzeva, Nina; Viisanen, Yrjö; Kotlyakov, Vladimir; Kasimov, Nikolay; Bondur, Valery; Matvienko, Gennady; Zilitinkevich, Sergej; Kulmala, Markku

    2014-05-01

    Pan-Eurasian Experiment (PEEX) is a new multidisciplinary research approach aiming at resolving the major uncertainties in the Earth system science and global sustainability questions in the Arctic and boreal Pan-Eurasian regions (Kulmala et al. 2011). The main goal of PEEX Research agenda is to contribute to solving the scientific questions that are specifically important for the Pan-Eurasian region in the coming years, in particular the global climate change and its consequences to nature and human society. Pan Eurasian region represents one the Earth most extensive areas of boreal forest (taiga) and the largest natural wetlands, thus being a significant source area of trace gas emissions, biogenic aerosol particles, and source and sink area for the greenhouse gas (GHG) exchange in a global scale (Guenther et al. 1995, Timkovsky et al. 2010, Tunved et al. 2006, Glagolev et al. 2010). One of the first activities of the PEEX initiative is to establish a process towards high level Pan-Eurasian Observation Networks. Siberian region is currently lacking a coordinated, coherent ground based atmosphere-ecosystem measurement network, which would be crucial component for observing and predicting the effects of climate change in the Northern Pan- Eurasian region The vision of the Pan-Eurasion network will be based on a hierarchical SMEAR-type (Stations Measuring Atmosphere-Ecosystem Interactions) integrated land-atmosphere observation system (Hari et al. 2009). A suite of stations have been selected for the Preliminary Phase of PEEX Observation network. These Preliminary Phase stations includes the SMEAR-type stations in Finland (SMEAR-I-II-II-IV stations), in Estonia (SMEAR-Järviselja) and in China (SMEAR-Nanjing) and selected stations in Russia and ecosystem station network in China. PEEX observation network will fill in the current observational gap in the Siberian region and bring the Siberian observation setup into international context with the with standardized or

  13. High Serum Adiponectin Level Is a Risk Factor for Anemia in Japanese Men: A Prospective Observational Study of 1,029 Japanese Subjects

    PubMed Central

    Kohno, Kei; Narimatsu, Hiroto; Shiono, Yosuke; Suzuki, Ikuko; Kato, Yuichi; Sho, Ri; Otani, Katsumi; Ishizawa, Kenichi; Yamashita, Hidetoshi; Kubota, Isao; Ueno, Yoshiyuki; Kato, Takeo; Fukao, Akira; Kayama, Takamasa

    2016-01-01

    Erythroid abnormalities including anemia and polycythemia are often observed in the general clinical setting. Because recent studies reported that adiponectin negatively affects hematopoiesis, we performed a prospective observational study to assess the relationship between anemia and adiponectin, as well as other parameters, in 1029 Japanese subjects (477 men and 552 women) 40 years of age and older. Body measurements, blood tests, and nutrition intake studies were performed at baseline, and 5 to 7 years later (follow-up). Hemoglobin (Hb) and hematocrit (Hct) levels in men with high serum adiponectin levels were lower at follow-up than at baseline. Multiple regression analysis showed that age, body mass index, adiponectin, and glutamic-pyruvic transaminase were significantly associated with erythroid-related variables (red blood cells, Hb, and Hct) in both men and women (P <0.05). In a logistic regression analysis, adiponectin, fasting blood glucose, and β-natriuretic peptide were significant risk factors for anemia in men, and blood urea nitrogen and amylase were significant risk factors in women. Physical features and nutrient intake were not risk factors for anemia. Our study demonstrates, both clinically and epidemiologically, that a high serum adiponectin level decreases the amounts of erythroid-related variables and is a risk factor for anemia in Japanese men. PMID:27918575

  14. Observation Status, Poverty, and High Financial Liability Among Medicare Beneficiaries.

    PubMed

    Goldstein, Jennifer N; Zhang, Zugui; Schwartz, J Sanford; Hicks, LeRoi S

    2018-01-01

    Medicare beneficiaries hospitalized under observation status are subject to cost-sharing with no spending limit under Medicare Part B. Because low-income status is associated with increased hospital use, there is concern that such beneficiaries may be at increased risk for high use and out-of-pocket costs related to observation care. Our objective was to determine whether low-income Medicare beneficiaries are at risk for high use and high financial liability for observation care compared with higher-income beneficiaries. We performed a retrospective, observational analysis of Medicare Part B claims and US Census Bureau data from 2013. Medicare beneficiaries with Part A and B coverage for the full calendar year, with 1 or more observation stay(s), were included in the study. Beneficiaries were divided into quartiles representing poverty level. The associations between poverty quartile and high use of observation care and between poverty quartile and high financial liability for observation care were evaluated. After multivariate adjustment, the risk of high use was higher for beneficiaries in the poor (Quartile 3) and poorest (Quartile 4) quartiles compared with those in the wealthiest quartile (Quartile 1) (adjusted odds ratio [AOR], 1.21; 95% confidence interval [CI], 1.13-1.31; AOR, 1.24; 95% CI, 1.16-1.33). The risk of high financial liability was higher in every poverty quartile compared with the wealthiest and peaked in Quartile 3, which represented the poor but not the poorest beneficiaries (AOR, 1.17; 95% CI, 1.10-1.24). Poverty predicts high use of observation care. The poor or near poor may be at highest risk for high liability. Copyright © 2018 Elsevier Inc. All rights reserved.

  15. Ground-water levels in observation wells in Oklahoma, 1969-70

    USGS Publications Warehouse

    Moore, R.L.

    1972-01-01

    The investigation of the ground-water resources of Oklahoma by the U.S. Geological Survey in cooperation with the Oklahoma Water Resources Board includes a continuing program to collect records of water levels in selected observation wells on a systematic basis. These water-level records: (1) provide an index to available ground-water supplies; (2) facilitate the prediction of trends in water levels that will indicate likely changes in storage; (3) aid in the prediction of the base flow of streams; (4) provide information for use in basic research; (5) provide long-time continuous records of fluctuations of water levels in representative wells; and (6) serve as a framework to which other types of hydrologic data my be related. Prior to 1956, measurements of water levels in observation wells in Oklahoma were included in water-supply papers published annually by the U.S. Geological Survey. Beginning with the 1956 calendar year, however, Geological Survey water-level reports will contain only records of a selected network of observation wells, and will be published at 5-year intervals. The first of this series, for the 1956-59 period was published in 1962. In addition to the water-supply papers, the U.S. Geological Survey, cooperation with the Oklahoma Water Resources Board, has published the following informal reports on water levels in Oklahoma. Ground-water levels in observations wells in Oklahoma, 1956-60 Ground-water levels in observations wells in Oklahoma, 1961-62 Ground-water levels in observations wells in Oklahoma, 1963-64 Ground-water levels in observations wells in Oklahoma, 1965-66 Ground-water levels in observations wells in Oklahoma, 1967-68 Records of water-level measurements in wells in the Oklahoma Panhandle, 1966-70 Records of water-level measurements in wells in the Oklahoma Panhandle, 1971-72 The basic observation-well network in Oklahoma during the period 1969-70 included the following counties: Alfalfa, Beaver, Beckham, Caddo, Cimarron

  16. Psilocybin impairs high-level but not low-level motion perception.

    PubMed

    Carter, Olivia L; Pettigrew, John D; Burr, David C; Alais, David; Hasler, Felix; Vollenweider, Franz X

    2004-08-26

    The hallucinogenic serotonin(1A&2A) agonist psilocybin is known for its ability to induce illusions of motion in otherwise stationary objects or textured surfaces. This study investigated the effect of psilocybin on local and global motion processing in nine human volunteers. Using a forced choice direction of motion discrimination task we show that psilocybin selectively impairs coherence sensitivity for random dot patterns, likely mediated by high-level global motion detectors, but not contrast sensitivity for drifting gratings, believed to be mediated by low-level detectors. These results are in line with those observed within schizophrenic populations and are discussed in respect to the proposition that psilocybin may provide a model to investigate clinical psychosis and the pharmacological underpinnings of visual perception in normal populations.

  17. High-energy solar flare observations at the Y2K maximum

    NASA Astrophysics Data System (ADS)

    Emslie, A. Gordon

    2000-04-01

    Solar flares afford an opportunity to observe processes associated with the acceleration and propagation of high-energy particles at a level of detail not accessible in any other astrophysical source. I will review some key results from previous high-energy solar flare observations, including those from the Compton Gamma-Ray Observatory, and the problems that they pose for our understanding of energy release and particle acceleration processes in the astrophysical environment. I will then discuss a program of high-energy observations to be carried out during the upcoming 2000-2001 solar maximum that is aimed at addressing and resolving these issues. A key element in this observational program is the High Energy Solar Spectroscopic Imager (HESSI) spacecraft, which will provide imaging spectroscopic observations with spatial, temporal, and energy resolutions commensurate with the physical processes believed to be operating, and will in addition provide the first true gamma-ray spectroscopy of an astrophysical source. .

  18. DUACS: Toward High Resolution Sea Level Products

    NASA Astrophysics Data System (ADS)

    Faugere, Y.; Gerald, D.; Ubelmann, C.; Claire, D.; Pujol, M. I.; Antoine, D.; Desjonqueres, J. D.; Picot, N.

    2016-12-01

    The DUACS system produces, as part of the CNES/SALP project, and the Copernicus Marine Environment and Monitoring Service, high quality multimission altimetry Sea Level products for oceanographic applications, climate forecasting centers, geophysic and biology communities... These products consist in directly usable and easy to manipulate Level 3 (along-track cross-calibrated SLA) and Level 4 products (multiple sensors merged as maps or time series) and are available in global and regional version (Mediterranean Sea, Arctic, European Shelves …).The quality of the products is today limited by the altimeter technology "Low Resolution Mode" (LRM), and the lack of available observations. The launch of 2 new satellites in 2016, Jason-3 and Sentinel-3A, opens new perspectives. Using the global Synthetic Aperture Radar mode (SARM) coverage of S3A and optimizing the LRM altimeter processing (retracking, editing, ...) will allow us to fully exploit the fine-scale content of the altimetric missions. Thanks to this increase of real time altimetry observations we will also be able to improve Level-4 products by combining these new Level-3 products and new mapping methodology, such as dynamic interpolation. Finally these improvements will benefit to downstream products : geostrophic currents, Lagrangian products, eddy atlas… Overcoming all these challenges will provide major upgrades of Sea Level products to better fulfill user needs.

  19. Recent Advances in Observations of Ground-level Auroral Kilometric Radiation

    NASA Astrophysics Data System (ADS)

    Labelle, J. W.; Ritter, J.; Pasternak, S.; Anderson, R. R.; Kojima, H.; Frey, H. U.

    2011-12-01

    Recently LaBelle and Anderson [2011] reported the first definitive observations of AKR at ground level, confirmed through simultaneous measurements on the Geotail spacecraft and at South Pole Station, Antarctica. The initial observations consisted of three examples recorded in 2004. An Antarctic observing site is critical for observing ground level AKR which is obscured by man-made broadcast signals at northern hemisphere locations. Examination of 2008 austral winter radio data from Antarctic Automatic Geophysical Observatories (AGOs) of the Polar Experiment Network for Geospace Upper-atmosphere Investigations (PENGUIn) network and South Pole Station reveals 37 ground level AKR events on 23 different days, 30 of which are confirmed by correlation with AKR observed with the Geotail spacecraft. The location of the Geotail spacecraft appears to be a significant factor enabling coincident measurements. Six of the AKR events are detected at two or three ground-level observatories separated by approximately 500 km, suggesting that the events illuminate an area comparable to a 500-km diameter. For 14 events on ten nights, photometer and all-sky imager data from South Pole and AGOs were examined; in ten cases, locations of auroral arcs could be determined at the times of the events. In eight of those cases, the AKR was detected at observatories poleward of the auroral arcs, and in the other two cases the aurora was approximately overhead at the observatory where AKR was detected. These observations suggest that the AKR signals may be ducted to ground level along magnetic field lines rather than propagating directly from the AKR source region of approximately 5000 km altitude. Correlations between structures in the AKR and intensifications of auroral arcs are occasionally observed but are rare. The ground-level AKR events have a local time distribution similar to that of AKR observed from satellites, peaking in the pre-midnight to midnight sector. This data base of >30

  20. Sustained transmission of high-level azithromycin-resistant Neisseria gonorrhoeae in England: an observational study.

    PubMed

    Fifer, Helen; Cole, Michelle; Hughes, Gwenda; Padfield, Simon; Smolarchuk, Christa; Woodford, Neil; Wensley, Adrian; Mustafa, Nazim; Schaefer, Ulf; Myers, Richard; Templeton, Kate; Shepherd, Jill; Underwood, Anthony

    2018-05-01

    Between Nov 3, 2014, and Feb 24, 2017, 70 cases of high-level azithromycin-resistant (HL-AziR; minimum inhibitory concentration [MIC] ≥256 mg/L) Neisseria gonorrhoeae were reported from across England. Whole-genome sequencing was done to investigate this outbreak to determine whether the ongoing outbreak represented clonal spread of an HL-AziR N gonorrhoeae strain identified in Leeds. We also wanted to elucidate the molecular mechanisms of azithromycin resistance in N gonorrhoeae in the UK. In this observational study, whole-genome sequencing was done on the HL-AziR N gonorrhoeae isolates from England. As comparators, 110 isolates from the UK and Ireland with a range of azithromycin MICs were also sequenced, including eight isolates from Scotland with azithromycin MICs ranging from 0·12 mg/L to 1·00 mg/L that were N gonorrhoeae multi-antigen sequence type 9768 (ST9768), which was the sequence type initially responsible for the outbreak. The presence of mutations or genes associated with azithromycin resistance was also investigated. 37 of the 60 HL-AziR isolates from England belonged to ST9768, and were genetically similar (mean 4·3 single-nucleotide polymorphisms). A 2059A→G mutation was detected in three or all four alleles of the 23S rRNA gene. Five susceptible ST9768 isolates had one mutated 23S rRNA allele and one low-level resistant ST9768 isolate had two mutated alleles. Sustained transmission of a successful HL-AziR clone was seen across England. Mutation 2059A→G was found in isolates with lower azithromycin MICs. Azithromycin exposure might have provided the selection pressure for one or two mutated copies of the 23S rRNA gene to recombine with wild-type copies, leading to three or four mutated copies and the HL-AziR phenotype. HL-AziR could emerge in isolates with low azithromycin MICs and eliminate the effectiveness of azithromycin as part of dual therapy for the treatment of gonorrhoea. Public Health England. Copyright © 2018 Elsevier Ltd. All

  1. Sea Level Data Archaeology for the Global Sea Level Observing System (GLOSS)

    NASA Astrophysics Data System (ADS)

    Bradshaw, Elizabeth; Matthews, Andy; Rickards, Lesley; Jevrejeva, Svetlana

    2015-04-01

    The Global Sea Level Observing System (GLOSS) was set up in 1985 to collect long term tide gauge observations and has carried out a number of data archaeology activities over the past decade, including sending member organisations questionnaires to report on their repositories. The GLOSS Group of Experts (GLOSS GE) is looking to future developments in sea level data archaeology and will provide its user community with guidance on finding, digitising, quality controlling and distributing historic records. Many records may not be held in organisational archives and may instead by in national libraries, archives and other collections. GLOSS will promote a Citizen Science approach to discovering long term records by providing tools for volunteers to report data. Tide gauge data come in two different formats, charts and hand-written ledgers. Charts are paper analogue records generated by the mechanical instrument driving a pen trace. Several GLOSS members have developed software to automatically digitise these charts and the various methods were reported in a paper on automated techniques for the digitization of archived mareograms, delivered to the GLOSS GE 13th meeting. GLOSS is creating a repository of software for scanning analogue charts. NUNIEAU is the only publically available software for digitising tide gauge charts but other organisations have developed their own tide gauge digitising software that is available internally. There are several other freely available software packages that convert image data to numerical values. GLOSS could coordinate a comparison study of the various different digitising software programs by: Sending the same charts to each organisation and asking everyone to digitise them using their own procedures Comparing the digitised data Providing recommendations to the GLOSS community The other major form of analogue sea level data is handwritten ledgers, which are usually observations of high and low waters, but sometimes contain higher

  2. High contrast observations of bright stars with a starshade

    NASA Astrophysics Data System (ADS)

    Harness, Anthony; Cash, Webster; Warwick, Steve

    2017-11-01

    Starshades are a leading technology to enable the direct detection and spectroscopic characterization of Earth-like exoplanets. In an effort to advance starshade technology through system level demonstrations, the McMath-Pierce Solar Telescope was adapted to enable the suppression of astronomical sources with a starshade. The long baselines achievable with the heliostat provide measurements of starshade performance at a flight-like Fresnel number and resolution, aspects critical to the validation of optical models. The heliostat has provided the opportunity to perform the first astronomical observations with a starshade and has made science accessible in a unique parameter space, high contrast at moderate inner working angles. On-sky images are valuable for developing the experience and tools needed to extract science results from future starshade observations. We report on high contrast observations of nearby stars provided by a starshade. We achieve 5.6 × 10- 7 contrast at 30 arcseconds inner working angle on the star Vega and provide new photometric constraints on background stars near Vega.

  3. Can change in high-density lipoprotein cholesterol levels reduce cardiovascular risk?

    PubMed

    Dean, Bonnie B; Borenstein, Jeff E; Henning, James M; Knight, Kevin; Merz, C Noel Bairey

    2004-06-01

    The cardiovascular risk reduction observed in many trials of lipid-lowering agents is greater than expected on the basis of observed low-density lipoprotein cholesterol (LDL-C) level reductions. Our objective was to explore the degree to which high-density lipoprotein cholesterol (HDL-C) level changes explain cardiovascular risk reduction. A systematic review identified trials of lipid-lowering agents reporting changes in HDL-C and LDL-C levels and the incidence of coronary heart disease (CHD). The observed relative risk reduction (RRR) in CHD morbidity and mortality rates was calculated. The expected RRR, given the treatment effect on total cholesterol level, was calculated for each trial with logistic regression coefficients from observational studies. The difference between observed and expected RRR was plotted against the change in HDL-C level, and a least-squares regression line was calculated. Fifty-one trials were identified. Nineteen statin trials addressed the association of HDL-C with CHD. Limited numbers of trials of other therapies precluded additional analyses. Among statin trials, therapy reduced total cholesterol levels as much as 32% and LDL-C levels as much as 45%. HDL-C level increases were <10%. Treatment effect on HDL-C levels was not a significant linear predictor of the difference in observed and expected CHD mortality rates, although we observed a trend in this direction (P =.08). Similarly, HDL-C effect was not a significant linear predictor of the difference between observed and expected RRRs for CHD morbidity (P =.20). Although a linear trend toward greater risk reduction was observed with greater effects on HDL-C, differences were not statistically significant. The narrow range of HDL-C level increases in the statin trials likely reduced our ability to detect a beneficial HDL-C effect, if present.

  4. Hydroxymethane sulfonate as a possible explanation for observed high levels of particulate sulfur during severe winter haze episodes in Beijing, China.

    NASA Astrophysics Data System (ADS)

    Moch, J.; Jacob, D.; Mickley, L. J.; Cheng, Y.; Li, M.; Munger, J. W.; Wang, Y.

    2017-12-01

    Observed PM2.5 during severe winter haze in Beijing, China, may reach levels as high as 880 μg m-3, with sulfur compounds contributing significantly to PM2.5 composition. Such sulfur has been traditionally assumed to be sulfate, even though models fail to generate such large sulfate enhancements under cold and hazy conditions. We show that particulate sulfur in wintertime Beijing possibly occurs as an S(IV)-HCHO adduct, hydroxymethane sulfonate (HMS), formed by reaction of aqueous-phase HCHO and S(IV) in cloud droplets. We use a 1-D chemistry model extending from the surface through the boundary layer to examine the potential role of HMS during the Beijing haze events of December 2011 and January 2013. Observed and assimilated meteorological fields including cloud liquid water were applied to the model, and we test the sensitivity of HMS formation to cloud pH and ambient SO2 and HCHO. Surface observations from the two haze events show excess ammonium in the aerosol, indicating cloud pH may be relatively high. Model results show that once cloud pH exceeds 4.5, HMS can accumulate rapidly, reaching a few hundred μg m-3 in a few hours. The timing of HMS formation is controlled by the presence of cloud liquid water, with eddy driven diffusion bringing HMS to the surface. The magnitude of HMS peaks is limited by the supply of HCHO. HMS episodes in the model end gradually over 1-3 days as fresh air is entrained into the boundary layer; in observations these episodes typically end when increasing wind speeds destabilize the boundary layer and disperses pollution. We find that consideration of HMS as a source of particulate sulfur significantly improves model match with observations. For example, assuming cloud pH of 5 and average surface SO2 and HCHO levels of 50 ppb and 5.5 ppb, we calculate mean HMS as 43.8 μg m-3 in January 2013, within 7 μg m-3 of observed particulate sulfur. Our 1-D model also captures the timing and magnitude of peak particulate sulfur in January

  5. A technique for estimating ground-water levels at sites in Rhode Island from observation-well data

    USGS Publications Warehouse

    Socolow, Roy S.; Frimpter, Michael H.; Turtora, Michael; Bell, Richard W.

    1994-01-01

    Estimates of future high, median, and low ground- water levels are needed for engineering and architectural design decisions and for appropriate selection of land uses. For example, the failure of individual underground sewage-disposal systems due to high ground-water levels can be prevented if accurate water-level estimates are available. Estimates of extreme or average conditions are needed because short duration preconstruction obser- vations are unlikely to be adequately represen- tative. Water-level records for 40 U.S. Geological Survey observation wells in Rhode Island were used to describe and interpret water-level fluctuations. The maximum annual range of water levels average about 6 feet in sand and gravel and 11 feet in till. These data were used to develop equations for estimating future high, median, and low water levels on the basis of any one measurement at a site and records of water levels at observation wells used as indexes. The estimating technique relies on several assumptions about temporal and spatial variations: (1) Water levels will vary in the future as they have in the past, (2) Water levels fluctuate seasonally (3) Ground-water fluctuations are dependent on site geology, and (4) Water levels throughout Rhode Island are subject to similar precipitation and climate. Comparison of 6,697 estimates of high, median, and low water levels (depth to water level exceeded 95, 50, and 5 percent of the time, respectively) with the actual measured levels exceeded 95, 50, and 5 percent of the time at 14 sites unaffected by pumping and unknown reasons, yielded mean squared errors ranging from 0.34 to 1.53 square feet, 0.30 to 1.22 square feet, and 0.32 to 2.55 square feet, respectively. (USGS)

  6. Maternal high-fat diet and offspring expression levels of vitamin K-dependent proteins.

    PubMed

    Lanham, S A; Cagampang, F R; Oreffo, R O C

    2014-12-01

    Studies suggest that bone growth and development and susceptibility to vascular disease in later life are influenced by maternal nutrition during intrauterine and early postnatal life. There is evidence for a role of vitamin K-dependent proteins (VKDPs) including osteocalcin, matrix Gla protein, periostin, and growth-arrest specific- protein 6, in both bone and vascular development. We have examined whether there are alterations in these VKDPs in bone and vascular tissue from offspring of mothers subjected to a nutritional challenge: a high-fat diet during pregnancy and postnatally, using 6-week-old mouse offspring. Bone site-specific and sex-specific differences across femoral and vertebral bone in male and female offspring were observed. Overall a high-fat maternal diet and offspring diet exacerbated the bone changes observed. Sex-specific differences and tissue-specific differences were observed in VKDP levels in aorta tissue from high-fat diet-fed female offspring from high-fat diet-fed mothers displaying increased levels of Gas6 and Ggcx compared with those of female controls. In contrast, differences were seen in VKDP levels in femoral bone of female offspring with lower expression levels of Mgp in offspring of mothers fed a high-fat diet compared with those of controls. We observed a significant correlation in Mgp expression levels within the femur to measures of bone structure of the femur and vertebra, particularly in the male offspring cohort. In summary, the current study has highlighted the importance of maternal nutrition on offspring bone development and the correlation of VKDPs to bone structure.

  7. Alkaline Earth Core Level Photoemission Spectroscopy of High-Temperature Superconductors

    NASA Technical Reports Server (NTRS)

    Vasquez, R.

    1993-01-01

    This paper examines photoemission measurements of the alkaline Earth core levels of high-temperature superconductors and related materials, models that seek to explain the large negative shifts observed relative to the corresponding alkaline Earth metals, and the effect of lattice site disorder on the core level spectra and the presence or absence of intrinsic surface peaks.

  8. Surface Layer Processes And Nocturnal Low Level Jet Development--An Observational Study During Pecan

    DTIC Science & Technology

    2016-12-01

    PROCESSES AND NOCTURNAL LOW-LEVEL JET DEVELOPMENT—AN OBSERVATIONAL STUDY DURING PECAN by Michael K. Beall December 2016 Thesis Advisor... OBSERVATIONAL STUDY DURING PECAN 5. FUNDING NUMBERS 6. AUTHOR(S) Michael K. Beall 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate... research project and collected high-resolution stable boundary layer data as it evolved through the night. The objective of this study was to use this

  9. Upper-level enhancement of microphysical processes in extratropical cyclones observed during OLYMPEX

    NASA Astrophysics Data System (ADS)

    Rowe, A.; McMurdie, L. A.; Houze, R.; Zagrodnik, J. P.; Schuldt, T.; Chaplin, M.

    2017-12-01

    Data collected during the Olympic Mountains Experiment (OLYMPEX) of fall 2015-winter 2016 offer a unique opportunity to document enhancement of precipitation on the windward side of a mountain range as mid-latitude cyclones encountered the complex terrain of the Olympic Mountains. During the campaign, extensive instrumentation was deployed, including ground-based dual-polarization Doppler radars on the windward and leeward sides of the mountains and research aircraft providing in situ microphysical measurements and triple-frequency radar data over the ground-based sites and highest elevations. These datasets provide unprecedented detail on microphysical and dynamical processes associated with precipitation enhancement. Previous studies of precipitation enhancement over mountains have focused on surface rainfall amounts. However, the airflow over the terrain affects precipitation throughout the vertical columns of the atmosphere passing over the mountains. The OLYMPEX data were collected in a way that allows the mechanisms leading to enhancement to be examined at all levels. In particular, NASA's S-band and the NSF/CSWR DOW6 X-band dual-polarization radars provided high-resolution vertical cross sections in sectors upwind and over the mountains. The degree of upper-level enhancement seen in these radar data was most pronounced when the integrated vapor transport was strong, stability was moist neutral, and melting levels were relatively high. These conditions were often found within the warm sectors of the mid-latitude cyclones observed in OLYMPEX. Within widespread stratiform echo, radar data revealed layers of enhanced differential reflectivity aloft in addition to the enhanced reflectivity. In situ microphysical probe data from the University of North Dakota Citation aircraft were obtained in the context of these ground-based radar observations, which along with observations from the APR3 radar aboard the DC8 research aircraft, provide a unique dataset for

  10. Ground-water levels in observation wells in Oklahoma, 1963-64

    USGS Publications Warehouse

    Wood, P.R.

    1965-01-01

    The investigation of the ground-water resources of Oklahoma by the U.S. Geological Survey in cooperation with the Oklahoma Water Resources Board includes a continuing program to collect records of water levels in selected observation wells on a systematic basis. These water-level records: (1) provide an index to available ground-water supplies; (2) facilitate the prediction of trends in water levels that will indicate likely changes in storage; (3) aid in the prediction of the base flow of streams; (4) provide information for use in basic research; (5) provide long-time continuous records of fluctuations of water levels in representative wells; and (6) serve as a framework to which other types of hydrologic data my be related. Prior to 1956, measurements of water levels in observation wells in Oklahoma were included in water-supply papers published annually by the U.S. Geological Survey. Beginning with the 1956 calendar year, however, Geological Survey water-level reports will contain only records of a selected network of observation wells, and will be published at 5-year intervals. The first of this series, for the 1956-59 period was published in 1962. This report has been prepared primarily to present water-level records of wells not included in the Federal network. However, for the sake of completeness it includes water-level records of Federal wells that either have been or will be published in water-supply papers since 1955. This report, which contains water-level records for the 2-year period (1963-64), is the third of a series presenting water-level records for all permanent observations wells in Oklahoma. The first report, published in 1963, contains water-level records for the 5-year period of (1956-60). The second report, published in 1964, contains water-level records for the 2-year period (1961-62.) (available as photostat copy only)

  11. Integrating space geodesy and coastal sea level observations

    NASA Astrophysics Data System (ADS)

    Löfgren, J. S.; Haas, R.; Larson, K.; Scherneck, H.-G.

    2012-04-01

    The goal of the Global Geodetic Observing System (GGOS) is to monitor the Earth system, in particular with observations of the three fundamental geodetic observables: the Earth's shape, the Earth's gravity field and the Earth's rotational motion. A central part of GGOS is the network of globally distributed fundamental geodetic stations that allow the combination and integration of the different space geodetic techniques. One of these stations is the Onsala Space Observatory (OSO), on the west coast of Sweden, which operates equipment for geodetic Very Long Baseline Interferometry, Global Navigation Satellite System (GNSS), and superconducting gravimetry measurements, and additionally water vapour radiometers. The newest addition to the OSO fundamental geodetic station is a GNSS-based tide gauge (GNSS-TG). This installation integrates space geodesy with remote sensing of the local sea level. The GNSS-TG uses both direct GNSS-signals and GNSS-signals that are reflected off the sea surface. This is done using a zenith-looking Right Hand Circular Polarized (RHCP) and a nadir-looking Left Hand Circular Polarized (LHCP) antenna, respectively. Each of the two antennas is connected to a standard geodetic-type GNSS-receiver. The analysis of the data received with the RHCP-antenna allows one to determine land motion, while the analysis of the data received with the LHCP-antenna allows one to determine the sea surface height. Analysing both data sets together results in local sea level that is automatically corrected for land motion, meaning that the GNSS-TG can provide reliable sea-level estimates even in tectonically active regions. Previous results from the GNSS-TG, using carrier phase data, show a Root-Mean-Square (RMS) agreement of less than 5.9 cm with stilling well gauges located 18 km and 33 km away from OSO (Löfgren et al., 2011). This is lower than the RMS agreement between the two stilling well gauges (6.1 cm). Furthermore, significant ocean tidal signals have

  12. Ground-water levels in observation wells in Oklahoma, 1956-1960

    USGS Publications Warehouse

    Hart, D.L.

    1963-01-01

    The investigation of the ground-water resources of Oklahoma by the U.S. Geological Survey in cooperation with the Oklahoma Water Resources Board includes a continuing program to collect on a systematic basis records of water levels in selected observation wells. These water-level records: (1) provide an index to available ground-water supplies; (2) facilitate the prediction of trends in water levels that will indicate likely changes in storage; (3) aid in the prediction of the base flow of streams; (4) provide information for use in basic research; and (5) provide long-time continuous records of fluctuations of water levels in representative wells, These selected records also serve as a framework to which other types of hydrologic data may be related.Prior to 1956, measurements of water levels in observation wells in Oklahoma were included in water-supply papers published annually by the U.S. Geological Survey (table 1). Beginning with the 1956 calendar year, however, Federal water-level reports will contain only records of a selected network of observation wells, and will be published by the U.S. Geological Survey at 5-year intervals. The first of this series, for the 1956-59 period has recently been published.This report has been prepared primarily to present water-level records of wells not included in the Federal network. However, for the sake of completeness it includes water-level records of Federal wells that either have been or will be published in Water-Supply Papers since 1955. This report, which contains water-level records for the 5-year period (1956-60), is the first of a series presenting water-level records for all permanent observation wells in Oklahoma. It is planned that future water-level reports will be published at 2-year intervals.

  13. Ground-water levels in observation wells in Oklahoma, 1961-62

    USGS Publications Warehouse

    Wood, P.R.; Moeller, M.D.

    1964-01-01

    The investigation of the ground-water resources of Oklahoma by the U. S. Geological Survey in cooperation with the Oklahoma Water Resources Board includes a continuing program to collect records of water levels in selected observation wells on a systematic basis. These water-level records: (1) provide an index to available ground-water supplies; (2) facilitate the prediction of trends in water levels that will indicate likely changes in storage; (3) aid in the prediction of the base flow of streams; (4) provide information for use in basic research; (5) provide long-term continuous records of fluctuations of water levels in representative wells; and (6) serve as a framework to which other types of hydrologic data may be related.Prior to 1956, measurements of water levels in observation wells in Oklahoma were included in water-supply papers published annually by the U. S. Geological Survey (table 1). Beginning with the 1956 calendar year, however, Geological Survey water-level reports will contain only records of a selected network of observation wells, and will be published at 5-year intervals. The first of this series, for the 1956-59 period, was published in 1962.This report has been prepared primarily to present water-level records of wells not included in the Federal network. However, for the sake of completeness it includes water-level records of Federal wells that either have been or will be published in Water-Supply Papers since 1955. This report, which contains water-level records for the 2-year period (1961-62), is the second of a series presenting water-level records for all permanent observation wells in Oklahoma. The first report, published in 1963, contains water-level records for the 5-year period (1956-60).

  14. Ground-water levels in observation wells in Oklahoma, 1967-68

    USGS Publications Warehouse

    Bingham, R.H.

    1969-01-01

    The investigation of the ground-water resources of Oklahoma by the U.S. Geological Survey in cooperation with the Oklahoma Water Resources Board includes a continuing program to collect records of water levels in selected observation wells on a systematic basis. These water-level records: (1) provide an index to available ground-water supplies; (2) facilitate the prediction of trends in water levels that will indicate likely changes in storage; (3) aid in the prediction of the base flow of streams; (4) provide information for use in basic research; (5) provide long-time continuous records of fluctuations of water levels in representative wells; and (6) serve as a framework to which other types of hydrologic data my be related. Prior to 1956, measurements of water levels in observation wells in Oklahoma were included in water-supply papers published annually by the U.S. Geological Survey. Beginning with the 1956 calendar year, however, Geological Survey water-level reports will contain only records of a selected network of observation wells, and will be published at 5-year intervals. The first of this series, for the 1956-59 period was published in 1962. This report has been prepared primarily to present water-level records of wells not included in the Federal network. However, for the sake of completeness it includes water-level records of Federal wells that either have been or will be published in water-supply papers since 1955. This report, which contains water-level records for the 2-year period (1967-68), is the fifth in a series presenting water-level records for all permanent observations wells in Oklahoma. The first report, published in 1963, contains water-level records for the 2-year period of (1961-62); the second report, published in 1964, contains water-level records for the 2-year period (1961-62); the third report, published in 1965, contains water-level records for the 2-year period (1963-64); and the fourth report contains water-level records for

  15. A retrospective observational study of people with Type 1 diabetes with self-reported severe hypoglycaemia reveals high level of ambulance attendance but low levels of therapy change and specialist intervention.

    PubMed

    Field, B C T; Nayar, R; Kilvert, A; Baxter, M; Hickey, J; Cummings, M; Bain, S C

    2018-05-15

    To evaluate the impact of severe hypoglycaemia on NHS resources and overall glycaemic control in adults with Type 1 diabetes. An observational, retrospective study of adults (aged ≥ 18 years) with Type 1 diabetes reporting one or more episodes of severe hypoglycaemia during the preceding 24 months in 10 NHS hospital diabetes centres in England and Wales. The primary outcome was healthcare resource utilization associated with severe hypoglycaemia. Secondary outcomes included demographic and clinical characteristics, diabetes control and pathway of care. Some 140 episodes of severe hypoglycaemia were reported by 85 people during the 2-year observation period. Ambulances were called in 99 of 140 (71%) episodes and Accident and Emergency attendance occurred in 26 of 140 (19%) episodes, whereas 29 of 140 (21%) episode required no immediate help from healthcare providers. Participants attended a median of 5 (range 0-58) diabetes clinic consultations during the observation period; 13% (70 of 552) of all consultations were severe hypoglycaemia-related. Of the HbA 1c measurements recorded closest prior to severe hypoglycaemia (n = 119), only 7 of 119 measurements were < 48 mmol/mol (< 6.5%) and mean HbA 1c was 70 (sd 19) mmol/mol (8.5%, sd 1.7%). Some 119 changes to diabetes treatment were recorded during the observation period (median/person 0;, range 0-11), of which 52 of 119 changes (44%) followed severe hypoglycaemic events. We observed a high level of ambulance service intervention but surprisingly low levels of hypoglycaemia follow-up, therapy change and specialist intervention in people self-reporting severe hypoglycaemia. These results suggest there may be important gaps in care pathways for people with Type 1 diabetes self-reporting severe hypoglycaemia. © 2018 Diabetes UK.

  16. High levels of ultraviolet radiation observed by ground-based instruments below the 2011 Arctic ozone hole

    NASA Astrophysics Data System (ADS)

    Bernhard, G.; Dahlback, A.; Fioletov, V.; Heikkilä, A.; Johnsen, B.; Koskela, T.; Lakkala, K.; Svendby, T.

    2013-11-01

    Greatly increased levels of ultraviolet (UV) radiation were observed at thirteen Arctic and sub-Arctic ground stations in the spring of 2011, when the ozone abundance in the Arctic stratosphere dropped to the lowest amounts on record. Measurements of the noontime UV Index (UVI) during the low-ozone episode exceeded the climatological mean by up to 77% at locations in the western Arctic (Alaska, Canada, Greenland) and by up to 161% in Scandinavia. The UVI measured at the end of March at the Scandinavian sites was comparable to that typically observed 15-60 days later in the year when solar elevations are much higher. The cumulative UV dose measured during the period of the ozone anomaly exceeded the climatological mean by more than two standard deviations at 11 sites. Enhancements beyond three standard deviations were observed at seven sites and increases beyond four standard deviations at two sites. At the western sites, the episode occurred in March, when the Sun was still low in the sky, limiting absolute UVI anomalies to less than 0.5 UVI units. At the Scandinavian sites, absolute UVI anomalies ranged between 1.0 and 2.2 UVI units. For example, at Finse, Norway, the noontime UVI on 30 March was 4.7, while the climatological UVI is 2.5. Although a UVI of 4.7 is still considered moderate, UV levels of this amount can lead to sunburn and photokeratitis during outdoor activity when radiation is reflected upward by snow towards the face of a person or animal. At the western sites, UV anomalies can be well explained with ozone anomalies of up to 41% below the climatological mean. At the Scandinavian sites, low ozone can only explain a UVI increase of 50-60%. The remaining enhancement was mainly caused by the absence of clouds during the low-ozone period.

  17. High levels of ultraviolet radiation observed by ground-based instruments below the 2011 Arctic ozone hole

    NASA Astrophysics Data System (ADS)

    Bernhard, G.; Dahlback, A.; Fioletov, V.; Heikkilä, A.; Johnsen, B.; Koskela, T.; Lakkala, K.; Svendby, T. M.

    2013-06-01

    Greatly increased levels of ultraviolet (UV) radiation were observed at thirteen Arctic and sub-Arctic ground stations in the spring of 2011 when the ozone abundance in the Arctic stratosphere dropped to the lowest amounts on record. Measurements of the noontime UV Index (UVI) during the low-ozone episode exceeded the climatological mean by up to 77% at locations in the western Arctic (Alaska, Canada, Greenland) and by up to 161% in Scandinavia. The UVI measured at the end of March at the Scandinavian sites was comparable to that typically observed 15-60 days later in the year when solar elevations are much higher. The cumulative UV dose measured during the period of the ozone anomaly exceeded the climatological mean by more than two standard deviations at 11 sites. Enhancements beyond three standard deviations were observed at seven sites and increases beyond four standard deviations at two sites. At the western sites, the episode occurred in March when the Sun was still low in the sky, limiting absolute UVI anomalies to less than 0.5 UVI units. At the Scandinavian sites, absolute UVI anomalies ranged between 1.0 and 2.2 UVI units. For example, at Finse, Norway, the noontime UVI on 30 March was 4.7 while the climatological UVI is 2.5. Although a UVI of 4.7 is still considered moderate, UV levels of this amount can lead to sunburn and photokeratitis during outdoor activity when radiation is reflected upward by snow towards the face of a person or animal. At the western sites, UV anomalies can be well explained with ozone anomalies of up to 41% below the climatological mean. At the Scandinavian sites, low ozone can only explain a UVI increase by 50-60%. The remaining enhancement was mainly caused by the absence of clouds during the low-ozone period.

  18. High estradiol levels improve false memory rates and meta-memory in highly schizotypal women.

    PubMed

    Hodgetts, Sophie; Hausmann, Markus; Weis, Susanne

    2015-10-30

    Overconfidence in false memories is often found in patients with schizophrenia and healthy participants with high levels of schizotypy, indicating an impairment of meta-cognition within the memory domain. In general, cognitive control is suggested to be modulated by natural fluctuations in oestrogen. However, whether oestrogen exerts beneficial effects on meta-memory has not yet been investigated. The present study sought to provide evidence that high levels of schizotypy are associated with increased false memory rates and overconfidence in false memories, and that these processes may be modulated by natural differences in estradiol levels. Using the Deese-Roediger-McDermott paradigm, it was found that highly schizotypal participants with high estradiol produced significantly fewer false memories than those with low estradiol. No such difference was found within the low schizotypy participants. Highly schizotypal participants with high estradiol were also less confident in their false memories than those with low estradiol; low schizotypy participants with high estradiol were more confident. However, these differences only approached significance. These findings suggest that the beneficial effect of estradiol on memory and meta-memory observed in healthy participants is specific to highly schizotypal individuals and might be related to individual differences in baseline dopaminergic activity. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  19. Ground-water levels in observation wells in Oklahoma, 1965-66

    USGS Publications Warehouse

    Hart, D.L.

    1967-01-01

    The investigation of the ground-water resources of Oklahoma by the U.S. Geological Survey in cooperation with the Oklahoma Water Resources Board includes a continuing program to collect records of water levels in selected observation wells on a systematic basis. These water-level records: (1) provide an index to available ground-water supplies; (2) facilitate the prediction of trends in water levels that will indicate likely changes in storage; (3) aid in the prediction of the base flow of streams; (4) provide information for use in basic research; (5) provide long-time continuous records of fluctuations of water levels in representative wells; and (6) serve as a framework to which other types of hydrologic data my be related. Prior to 1956, measurements of water levels in observation wells in Oklahoma were included in water-supply papers published annually by the U.S. Geological Survey. Beginning with the 1956 calendar year, however, Geological Survey water-level reports will contain only records of a selected network of observation wells, and will be published at 5-year intervals. The first of this series, for the 1956-59 period was published in 1962. This report has been prepared primarily to present water-level records of wells not included in the Federal network. However, for the sake of completeness it includes water-level records of Federal wells that either have been or will be published in water-supply papers since 1955. This report, which contains water-level records for the 2-year period (1965-66), is the fourth in a series presenting water-level records for all permanent observations wells in Oklahoma. The first report, published in 1963, contains water-level records for the 2-year period of (1961-62); the second report, published in 1964, contains water-level records for the 2-year period (1961-62); and the third report, published in 1965, contains water-level records for the 2-year period (1963-64). (available as photostat copy only)

  20. Carboxyhemoglobin levels in medical intensive care patients: a retrospective, observational study

    PubMed Central

    2012-01-01

    Introduction Critical illness leads to increased endogenous production of carbon monoxide (CO) due to the induction of the stress-response enzyme, heme oxygenase-1 (HO-1). There is evidence for the cytoprotective and anti-inflammatory effects of CO based on animal studies. In critically ill patients after cardiothoracic surgery, low minimum and high maximum carboxyhemoglobin (COHb) levels were shown to be associated with increased mortality, which suggests that there is an 'optimal range' for HO-1 activity. Our study aimed to test whether this relationship between COHb and outcome exists in non-surgical ICU patients. Methods We conducted a retrospective, observational study in a medical ICU at a university hospital in Vienna, Austria involving 868 critically ill patients. No interventions were undertaken. Arterial COHb was measured on admission and during the course of treatment in the ICU. The association between arterial COHb levels and ICU mortality was evaluated using bivariate tests and a logistic regression model. Results Minimum COHb levels were slightly lower in non-survivors compared to survivors (0.9%, 0.7% to 1.2% versus 1.2%, 0.9% to 1.5%; P = 0.0001), and the average COHb levels were marginally lower in non-survivors compared to survivors (1.5%, 1.2% to 1.8% versus 1.6%, 1.4% to 1.9%, P = 0.003). The multivariate logistic regression analysis revealed that the association between a low minimum COHb level and increased mortality was independent of the severity of illness and the type of organ failure. Conclusions Critically ill patients surviving the admission to a medical ICU had slightly higher minimum and marginally higher average COHb levels when compared to non-survivors. Even though the observed differences are statistically significant, the minute margins would not qualify COHb as a predictive marker for ICU mortality. PMID:22236404

  1. Carboxyhemoglobin levels in medical intensive care patients: a retrospective, observational study.

    PubMed

    Fazekas, Andreas S; Wewalka, Marlene; Zauner, Christian; Funk, Georg-Christian

    2012-01-11

    Critical illness leads to increased endogenous production of carbon monoxide (CO) due to the induction of the stress-response enzyme, heme oxygenase-1 (HO-1). There is evidence for the cytoprotective and anti-inflammatory effects of CO based on animal studies. In critically ill patients after cardiothoracic surgery, low minimum and high maximum carboxyhemoglobin (COHb) levels were shown to be associated with increased mortality, which suggests that there is an 'optimal range' for HO-1 activity. Our study aimed to test whether this relationship between COHb and outcome exists in non-surgical ICU patients. We conducted a retrospective, observational study in a medical ICU at a university hospital in Vienna, Austria involving 868 critically ill patients. No interventions were undertaken. Arterial COHb was measured on admission and during the course of treatment in the ICU. The association between arterial COHb levels and ICU mortality was evaluated using bivariate tests and a logistic regression model. Minimum COHb levels were slightly lower in non-survivors compared to survivors (0.9%, 0.7% to 1.2% versus 1.2%, 0.9% to 1.5%; P=0.0001), and the average COHb levels were marginally lower in non-survivors compared to survivors (1.5%, 1.2% to 1.8% versus 1.6%, 1.4% to 1.9%, P=0.003). The multivariate logistic regression analysis revealed that the association between a low minimum COHb level and increased mortality was independent of the severity of illness and the type of organ failure. Critically ill patients surviving the admission to a medical ICU had slightly higher minimum and marginally higher average COHb levels when compared to non-survivors. Even though the observed differences are statistically significant, the minute margins would not qualify COHb as a predictive marker for ICU mortality.

  2. Physical Activity in Public Parks of High and Low Socioeconomic Status in Colombia Using Observational Methods.

    PubMed

    Camargo, Diana Marina; Ramírez, Paula Camila; Quiroga, Vanesa; Ríos, Paola; Férmino, Rogério César; Sarmiento, Olga L

    2018-03-28

    Public parks are an important resource for the promotion of physical activity (PA). This is the first study in Colombia and the fourth in Latin America to describe the characteristics of park users and their levels of PA using objective measures. A systematic observation assessed sex, age, and the level of PA of users of 10 parks in an intermediate-size city in Colombia, classified in low (5 parks) and high (5 parks) socioeconomic status (SES). A total of 10 daily observations were conducted, in 5 days of the week during 3 periods: morning, afternoon, and evening. In total, 16,671 observations were completed, recording 46,047 users. A higher number of users per park, per day, were recorded in high SES (1195) versus low SES (647). More men were observed in low-SES than high-SES parks (70.1% vs 54.2%), as well as more children were observed in low-SES than high-SES parks (30.1% vs 15.9%). Older adults in high-SES parks were more frequent (9.5% vs 5.2%). Moderate to vigorous PA was higher in low-SES parks (71.7% vs 63.2%). Low-SES parks need more green spaces, walk/bike trails, and areas for PA. All parks need new programs to increase the number of users and their PA level, considering sex, age group, and period of the week.

  3. High-frequency sediment-level oscillations in the swash zone

    USGS Publications Warehouse

    Sallenger, A.H.; Richmond, B.M.

    1984-01-01

    Sediment-level oscillations with heights of about 6 cm and shore-normal lengths of order 10 m have been measured in the swash zone of a high-energy, coarse-sand beach. Crests of oscillations were shore parallel and continuous alongshore. The oscillations were of such low steepness (height-to-length ratio approximately 0.006) that they were difficult to detect visually. The period of oscillation ranged between 6 and 15 min and decreased landward across the swash zone. The sediment-level oscillations were progressive landward with an average migration rate in the middle to upper swash zone of 0.8 m min-1. Migration was caused mostly by erosion on the seaward flank of the crest of an oscillation during a period of net seaward sediment transport. Thus, the observed migration was a form migration landward rather than a migration involving net landward sediment transport. The observed sediment-level oscillations were different than sand waves or other swash-zone bedforms previously described. ?? 1984.

  4. High-Level Binocular Rivalry Effects

    PubMed Central

    Wolf, Michal; Hochstein, Shaul

    2011-01-01

    Binocular rivalry (BR) occurs when the brain cannot fuse percepts from the two eyes because they are different. We review results relating to an ongoing controversy regarding the cortical site of the BR mechanism. Some BR qualities suggest it is low-level: (1) BR, as its name implies, is usually between eyes and only low-levels have access to utrocular information. (2) All input to one eye is suppressed: blurring doesn’t stimulate accommodation; pupilary constrictions are reduced; probe detection is reduced. (3) Rivalry is affected by low-level attributes, contrast, spatial frequency, brightness, motion. (4) There is limited priming due to suppressed words or pictures. On the other hand, recent studies favor a high-level mechanism: (1) Rivalry occurs between patterns, not eyes, as in patchwork rivalry or a swapping paradigm. (2) Attention affects alternations. (3) Context affects dominance. There is conflicting evidence from physiological studies (single cell and fMRI) regarding cortical level(s) of conscious perception. We discuss the possibility of multiple BR sites and theoretical considerations that rule out this solution. We present new data regarding the locus of the BR switch by manipulating stimulus semantic content or high-level characteristics. Since these variations are represented at higher cortical levels, their affecting rivalry supports high-level BR intervention. In Experiment I, we measure rivalry when one eye views words and the other non-words and find significantly longer dominance durations for non-words. In Experiment II, we find longer dominance times for line drawings of simple, structurally impossible figures than for similar, possible objects. In Experiment III, we test the influence of idiomatic context on rivalry between words. Results show that generally words within their idiomatic context have longer mean dominance durations. We conclude that BR has high-level cortical influences, and may be controlled by a high-level mechanism

  5. Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses

    PubMed Central

    Liu, Ruijie; Holik, Aliaksei Z.; Su, Shian; Jansz, Natasha; Chen, Kelan; Leong, Huei San; Blewitt, Marnie E.; Asselin-Labat, Marie-Liesse; Smyth, Gordon K.; Ritchie, Matthew E.

    2015-01-01

    Variations in sample quality are frequently encountered in small RNA-sequencing experiments, and pose a major challenge in a differential expression analysis. Removal of high variation samples reduces noise, but at a cost of reducing power, thus limiting our ability to detect biologically meaningful changes. Similarly, retaining these samples in the analysis may not reveal any statistically significant changes due to the higher noise level. A compromise is to use all available data, but to down-weight the observations from more variable samples. We describe a statistical approach that facilitates this by modelling heterogeneity at both the sample and observational levels as part of the differential expression analysis. At the sample level this is achieved by fitting a log-linear variance model that includes common sample-specific or group-specific parameters that are shared between genes. The estimated sample variance factors are then converted to weights and combined with observational level weights obtained from the mean–variance relationship of the log-counts-per-million using ‘voom’. A comprehensive analysis involving both simulations and experimental RNA-sequencing data demonstrates that this strategy leads to a universally more powerful analysis and fewer false discoveries when compared to conventional approaches. This methodology has wide application and is implemented in the open-source ‘limma’ package. PMID:25925576

  6. Measuring progress of the global sea level observing system

    NASA Astrophysics Data System (ADS)

    Woodworth, Philip L.; Aarup, Thorkild; Merrifield, Mark; Mitchum, Gary T.; Le Provost, Christian

    Sea level is such a fundamental parameter in the sciences of oceanography geophysics, and climate change, that in the mid-1980s, the Intergovernmental Oceanographic Commission (IOC) established the Global Sea Level Observing System (GLOSS). GLOSS was to improve the quantity and quality of data provided to the Permanent Service for Mean Sea Level (PSMSL), and thereby, data for input to studies of long-term sea level change by the Intergovernmental Panel on Climate Change (IPCC). It would also provide the key data needed for international programs, such as the World Ocean Circulation Experiment (WOCE) and later, the Climate Variability and Predictability Programme (CLIVAR).GLOSS is now one of the main observation components of the Joint Technical Commission for Oceanography and Marine Meteorology (JCOMM) of IOC and the World Meteorological Organization (WMO). Progress and deficiencies in GLOSS were presented in July to the 22nd IOC Assembly at UNESCO in Paris and are contained in the GLOSS Assessment Report (GAR) [IOC, 2003a].

  7. Water level observations from Unmanned Aerial Vehicles (UAVs) for improving probabilistic estimations of interaction between rivers and groundwater

    NASA Astrophysics Data System (ADS)

    Bandini, Filippo; Butts, Michael; Vammen Jacobsen, Torsten; Bauer-Gottwein, Peter

    2016-04-01

    Integrated hydrological models are generally calibrated against observations of river discharge and piezometric head in groundwater aquifers. Integrated hydrological models are rarely calibrated against spatially distributed water level observations measured by either in-situ stations or spaceborne platforms. Indeed in-situ observations derived from ground-based stations are generally spaced too far apart to capture spatial patterns in the water surface. On the other hand spaceborne observations have limited spatial resolution. Additionally satellite observations have a temporal resolution which is not ideal for observing the temporal patterns of the hydrological variables during extreme events. UAVs (Unmanned Aerial Vehicles) offer several advantages: i) high spatial resolution; ii) tracking of the water body better than any satellite technology; iii) timing of the sampling merely depending on the operators. In this case study the Mølleåen river (Denmark) and its catchment have been simulated through an integrated hydrological model (MIKE 11-MIKE SHE). This model was initially calibrated against observations of river discharge retrieved by in-situ stations and against piezometric head of the aquifers. Subsequently the hydrological model has been calibrated against dense spatially distributed water level observations, which could potentially be retrieved by UAVs. Error characteristics of synthetic UAV water level observations were taken from a recent proof-of-concept study. Since the technology for ranging water level is under development, UAV synthetic water level observations were extracted from another model of the river with higher spatial resolution (cross sections located every 10 m). This model with high resolution is assumed to be absolute truth for the purpose of this work. The river model with the coarser resolution has been calibrated against the synthetic water level observations through Differential Evolution Adaptive Metropolis (DREAM) algorithm, an

  8. RPython high-level synthesis

    NASA Astrophysics Data System (ADS)

    Cieszewski, Radoslaw; Linczuk, Maciej

    2016-09-01

    The development of FPGA technology and the increasing complexity of applications in recent decades have forced compilers to move to higher abstraction levels. Compilers interprets an algorithmic description of a desired behavior written in High-Level Languages (HLLs) and translate it to Hardware Description Languages (HDLs). This paper presents a RPython based High-Level synthesis (HLS) compiler. The compiler get the configuration parameters and map RPython program to VHDL. Then, VHDL code can be used to program FPGA chips. In comparison of other technologies usage, FPGAs have the potential to achieve far greater performance than software as a result of omitting the fetch-decode-execute operations of General Purpose Processors (GPUs), and introduce more parallel computation. This can be exploited by utilizing many resources at the same time. Creating parallel algorithms computed with FPGAs in pure HDL is difficult and time consuming. Implementation time can be greatly reduced with High-Level Synthesis compiler. This article describes design methodologies and tools, implementation and first results of created VHDL backend for RPython compiler.

  9. HER2 over-expressing high grade endometrial cancer expresses high levels of p95HER2 variant.

    PubMed

    Growdon, Whitfield B; Groeneweg, Jolijn; Byron, Virginia; DiGloria, Celeste; Borger, Darrell R; Tambouret, Rosemary; Foster, Rosemary; Chenna, Ahmed; Sperinde, Jeff; Winslow, John; Rueda, Bo R

    2015-04-01

    Subsets of high grade endometrial cancer (EnCa) over-express HER2 (ERBB2), yet clinical trials have failed to demonstrate any anti-tumor activity utilizing trastuzumab, an approved platform for HER2 positive breast cancer (BrCa). A truncated p95HER2 variant lacking the trastuzumab binding site may confer resistance. The objective of this investigation was to characterize the expression of the p95HER2 truncated variant in EnCa. With institutional approval, 86 high grade EnCa tumors were identified with tumor specimens from surgeries performed between 2000 and 2011. Clinical data were collected and all specimens underwent tumor genotyping, HER2 immunohistochemistry (IHC, HercepTest®), HER2 fluorescent in situ hybridization (FISH), along with total HER2 (H2T) and p95HER2 assessment with VeraTag® testing. Regression models were used to compare a cohort of 86 breast tumors selected for equivalent HER2 protein expression. We identified 44 high grade endometrioid and 42 uterine serous carcinomas (USC). IHC identified high HER2 expression (2+ or 3+) in 59% of the tumors. HER2 gene amplification was observed in 16 tumors (12 USC, 4 endometrioid). Both HER2 gene amplification and protein expression correlated with H2T values. High p95HER2 expression above 2.8RF/mm2 was observed in 53% (n=54) with significant correlation with H2T levels. When matched to a cohort of 107 breast tumors based on HercepTest HER2 expression, high grade EnCa presented with higher p95 levels (p<0.001). These data demonstrate that compared to BrCa, high grade EnCa expresses higher levels of p95HER2 possibly providing rationale for the trastuzumab resistance observed in EnCa. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  10. Low-level and high-level modulations of fixational saccades and high frequency oscillatory brain activity in a visual object classification task

    PubMed Central

    Kosilo, Maciej; Wuerger, Sophie M.; Craddock, Matt; Jennings, Ben J.; Hunt, Amelia R.; Martinovic, Jasna

    2013-01-01

    Until recently induced gamma-band activity (GBA) was considered a neural marker of cortical object representation. However, induced GBA in the electroencephalogram (EEG) is susceptible to artifacts caused by miniature fixational saccades. Recent studies have demonstrated that fixational saccades also reflect high-level representational processes. Do high-level as opposed to low-level factors influence fixational saccades? What is the effect of these factors on artifact-free GBA? To investigate this, we conducted separate eye tracking and EEG experiments using identical designs. Participants classified line drawings as objects or non-objects. To introduce low-level differences, contours were defined along different directions in cardinal color space: S-cone-isolating, intermediate isoluminant, or a full-color stimulus, the latter containing an additional achromatic component. Prior to the classification task, object discrimination thresholds were measured and stimuli were scaled to matching suprathreshold levels for each participant. In both experiments, behavioral performance was best for full-color stimuli and worst for S-cone isolating stimuli. Saccade rates 200–700 ms after stimulus onset were modulated independently by low and high-level factors, being higher for full-color stimuli than for S-cone isolating stimuli and higher for objects. Low-amplitude evoked GBA and total GBA were observed in very few conditions, showing that paradigms with isoluminant stimuli may not be ideal for eliciting such responses. We conclude that cortical loops involved in the processing of objects are preferentially excited by stimuli that contain achromatic information. Their activation can lead to relatively early exploratory eye movements even for foveally-presented stimuli. PMID:24391611

  11. High serum level of the soluble CD30 identifies Chinese kidney transplant recipients at high risk of unfavorable outcome.

    PubMed

    Iv, R; He, Q; Wang, H P; Jin, J; Chen, Y; Chen, J H

    2008-12-01

    We sought to investigate the relationship between serum level of sCD30 and recipient/graft survival rates, rejection types, as well as other prognostic factors among Chinese kidney transplant patients. We performed enzyme-linked immunosorbent assays of serum sCD30 levels in duplicate among retrospective cohort of 707 renal transplant patients. The incidences of rejection increased in relation to the pretransplant sCD30 level. The reversal rates of rejection were 100%, 90.6%, and 78.6% for the low, intermediate, and high sCD30 groups. This observation suggested that high levels of sCD30 and pretransplant panel-reactive antibody (PRA)-positive patients are risk factors for acute rejection with odds ratios of 6.862 and 1.756. High sCD30 was an independent risk factor for functional graft survival. The 5-year graft survival rates were 99.39% +/- 6.1%, 93.11% +/- 1.93%, and 82.07% +/- 3.97% among the low, intermediate, and high sCD30 groups, while the 5-year recipient survival rates were 89.25% +/- 2.41%, 91.82% +/- 1.64%, and 88.85% +/- 2.36%, respectively. Increased sCD30 levels were observed among patients who were PRA-positive, cytomegalovirus antigens or antibodies positive, on long-term dialysis, and levels reflect immune status.

  12. OCCURRENCE OF HIGH-LEVEL AMINOGLYCOSIDE RESISTANCE IN ENVIRONMENTAL ISOLATES OF ENTEROCOCCI

    EPA Science Inventory

    High-level resistance fo aminoglycosides was observed in environmental isolates of enterococci. Various aquatic habitats, including agricultural runoff, creeks, rivers, wastewater, and wells, were analyzed. Strains of Enterococcus faecalis, e.faecium, E. gallinarum, and other Ent...

  13. High-Precision Image Aided Inertial Navigation with Known Features: Observability Analysis and Performance Evaluation

    PubMed Central

    Jiang, Weiping; Wang, Li; Niu, Xiaoji; Zhang, Quan; Zhang, Hui; Tang, Min; Hu, Xiangyun

    2014-01-01

    A high-precision image-aided inertial navigation system (INS) is proposed as an alternative to the carrier-phase-based differential Global Navigation Satellite Systems (CDGNSSs) when satellite-based navigation systems are unavailable. In this paper, the image/INS integrated algorithm is modeled by a tightly-coupled iterative extended Kalman filter (IEKF). Tightly-coupled integration ensures that the integrated system is reliable, even if few known feature points (i.e., less than three) are observed in the images. A new global observability analysis of this tightly-coupled integration is presented to guarantee that the system is observable under the necessary conditions. The analysis conclusions were verified by simulations and field tests. The field tests also indicate that high-precision position (centimeter-level) and attitude (half-degree-level)-integrated solutions can be achieved in a global reference. PMID:25330046

  14. High potassium level

    MedlinePlus

    ... level is very high, or if you have danger signs, such as changes in an ECG . Emergency ... Seifter JL. Potassium disorders. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine . 25th ed. Philadelphia, PA: ...

  15. Noisy Icebergs: Low Frequency Acoustic Noise Levels Observed off Palmyra Atoll

    NASA Astrophysics Data System (ADS)

    Matsumoto, H.; Wiggins, S. M.; Sirovic, A.; Tournadre, J.; Oleson, E.; Haxel, J. H.; Dziak, R. P.

    2016-12-01

    Annually tens of thousands of icebergs from Antarctica drift into the open ocean. In late 2007, two unusually large icebergs, B15a and C19a, entered the Pacific region of the Southern Ocean, and began rapidly disintegrating. Approximately 1.5 years later in April 2009, both icebergs had completely fragmented. An unappreciated aspect of the destructive processes that occur while these large icebergs break apart is the high acoustic source levels that are generated and the contribution of those signals to the ocean soundscape throughout the southern hemisphere. Matsumoto et al. (2014) found evidence of B15a and C19a affecting low-frequency noise levels below 36 Hz at 8°N, 110°W in the eastern equatorial Pacific at a range of 7,500 km. Similar evidence for disintegrating icebergs affecting soundscapes at a similar range was observed in data from 2007-2009 High-frequency Acoustic Recording Package recordings by Scripps Institution of Oceanography near Palmyra atoll in the central equatorial Pacific. Noise levels rose in 2007 as the icebergs entered the Pacific and decreased as the destructive processes declined and the icebergs disintegrated in 2009. This suggests that iceberg sounds are a significant natural noise source in the global ocean, and the area affected by the destructive processes during their decomposition can be as large as the entire southern hemisphere.

  16. Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses.

    PubMed

    Liu, Ruijie; Holik, Aliaksei Z; Su, Shian; Jansz, Natasha; Chen, Kelan; Leong, Huei San; Blewitt, Marnie E; Asselin-Labat, Marie-Liesse; Smyth, Gordon K; Ritchie, Matthew E

    2015-09-03

    Variations in sample quality are frequently encountered in small RNA-sequencing experiments, and pose a major challenge in a differential expression analysis. Removal of high variation samples reduces noise, but at a cost of reducing power, thus limiting our ability to detect biologically meaningful changes. Similarly, retaining these samples in the analysis may not reveal any statistically significant changes due to the higher noise level. A compromise is to use all available data, but to down-weight the observations from more variable samples. We describe a statistical approach that facilitates this by modelling heterogeneity at both the sample and observational levels as part of the differential expression analysis. At the sample level this is achieved by fitting a log-linear variance model that includes common sample-specific or group-specific parameters that are shared between genes. The estimated sample variance factors are then converted to weights and combined with observational level weights obtained from the mean-variance relationship of the log-counts-per-million using 'voom'. A comprehensive analysis involving both simulations and experimental RNA-sequencing data demonstrates that this strategy leads to a universally more powerful analysis and fewer false discoveries when compared to conventional approaches. This methodology has wide application and is implemented in the open-source 'limma' package. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  17. Future sea level rise constrained by observations and long-term commitment.

    PubMed

    Mengel, Matthias; Levermann, Anders; Frieler, Katja; Robinson, Alexander; Marzeion, Ben; Winkelmann, Ricarda

    2016-03-08

    Sea level has been steadily rising over the past century, predominantly due to anthropogenic climate change. The rate of sea level rise will keep increasing with continued global warming, and, even if temperatures are stabilized through the phasing out of greenhouse gas emissions, sea level is still expected to rise for centuries. This will affect coastal areas worldwide, and robust projections are needed to assess mitigation options and guide adaptation measures. Here we combine the equilibrium response of the main sea level rise contributions with their last century's observed contribution to constrain projections of future sea level rise. Our model is calibrated to a set of observations for each contribution, and the observational and climate uncertainties are combined to produce uncertainty ranges for 21st century sea level rise. We project anthropogenic sea level rise of 28-56 cm, 37-77 cm, and 57-131 cm in 2100 for the greenhouse gas concentration scenarios RCP26, RCP45, and RCP85, respectively. Our uncertainty ranges for total sea level rise overlap with the process-based estimates of the Intergovernmental Panel on Climate Change. The "constrained extrapolation" approach generalizes earlier global semiempirical models and may therefore lead to a better understanding of the discrepancies with process-based projections.

  18. Future sea level rise constrained by observations and long-term commitment

    PubMed Central

    Mengel, Matthias; Levermann, Anders; Frieler, Katja; Robinson, Alexander; Marzeion, Ben; Winkelmann, Ricarda

    2016-01-01

    Sea level has been steadily rising over the past century, predominantly due to anthropogenic climate change. The rate of sea level rise will keep increasing with continued global warming, and, even if temperatures are stabilized through the phasing out of greenhouse gas emissions, sea level is still expected to rise for centuries. This will affect coastal areas worldwide, and robust projections are needed to assess mitigation options and guide adaptation measures. Here we combine the equilibrium response of the main sea level rise contributions with their last century's observed contribution to constrain projections of future sea level rise. Our model is calibrated to a set of observations for each contribution, and the observational and climate uncertainties are combined to produce uncertainty ranges for 21st century sea level rise. We project anthropogenic sea level rise of 28–56 cm, 37–77 cm, and 57–131 cm in 2100 for the greenhouse gas concentration scenarios RCP26, RCP45, and RCP85, respectively. Our uncertainty ranges for total sea level rise overlap with the process-based estimates of the Intergovernmental Panel on Climate Change. The “constrained extrapolation” approach generalizes earlier global semiempirical models and may therefore lead to a better understanding of the discrepancies with process-based projections. PMID:26903648

  19. High pressure liquid level monitor

    DOEpatents

    Bean, Vern E.; Long, Frederick G.

    1984-01-01

    A liquid level monitor for tracking the level of a coal slurry in a high-pressure vessel including a toroidal-shaped float with magnetically permeable bands thereon disposed within the vessel, two pairs of magnetic field generators and detectors disposed outside the vessel adjacent the top and bottom thereof and magnetically coupled to the magnetically permeable bands on the float, and signal processing circuitry for combining signals from the top and bottom detectors for generating a monotonically increasing analog control signal which is a function of liquid level. The control signal may be utilized to operate high-pressure control valves associated with processes in which the high-pressure vessel is used.

  20. A HIGH-LEVEL CALCULATION OF THE PROTON AFFINITY OF DIBORANE

    EPA Science Inventory

    The experimental proton affinity of diborane (B2H6) is based on an unstable species, B2H,+, 4 which has been observed only at low temperatures. The present work calculates the proton 5 affinity of diborane using the Gaussian-3 method and other high-level compound ab initio 6 met...

  1. High-spectral resolution solar microwave observations

    NASA Technical Reports Server (NTRS)

    Hurford, G. J.

    1986-01-01

    The application of high-spectral resolution microwave observations to the study of solar activity is discussed with particular emphasis on the frequency dependence of microwave emission from solar active regions. A shell model of gyroresonance emission from active regions is described which suggest that high-spectral resolution, spatially-resolved observations can provide quantitative information about the magnetic field distribution at the base of the corona. Corresponding observations of a single sunspot with the Owens Valley frequency-agile interferometer at 56 frequencies between 1.2 and 14 Ghs are presented. The overall form of the observed size and brightness temperature spectra was consistent with expectations based on the shell model, although there were differences of potential physical significance. The merits and weaknesses of microwave spectroscopy as a technique for measuring magnetic fields in the solar corona are briefly discussed.

  2. Recharge signal identification based on groundwater level observations.

    PubMed

    Yu, Hwa-Lung; Chu, Hone-Jay

    2012-10-01

    This study applied a method of the rotated empirical orthogonal functions to directly decompose the space-time groundwater level variations and determine the potential recharge zones by investigating the correlation between the identified groundwater signals and the observed local rainfall records. The approach is used to analyze the spatiotemporal process of piezometric heads estimated by Bayesian maximum entropy method from monthly observations of 45 wells in 1999-2007 located in the Pingtung Plain of Taiwan. From the results, the primary potential recharge area is located at the proximal fan areas where the recharge process accounts for 88% of the spatiotemporal variations of piezometric heads in the study area. The decomposition of groundwater levels associated with rainfall can provide information on the recharge process since rainfall is an important contributor to groundwater recharge in semi-arid regions. Correlation analysis shows that the identified recharge closely associates with the temporal variation of the local precipitation with a delay of 1-2 months in the study area.

  3. DEMETER observations of bursty MF emissions and their relation to ground-level auroral MF burst

    NASA Astrophysics Data System (ADS)

    Broughton, M. C.; LaBelle, J.; Parrot, M.

    2014-12-01

    A survey of medium frequency (MF) electric field data from selected orbits of the Detection of Electro-Magnetic Emissions Transmitted from Earthquakes (DEMETER) spacecraft reveals 68 examples of a new type of bursty MF emissions occurring at high latitudes associated with auroral phenomena. These resemble auroral MF burst, a natural radio emission observed at ground level near local substorm onsets. Similar to MF burst, the bursty MF waves observed by DEMETER have broadband, impulsive frequency structure covering 1.5-3.0 MHz, amplitudes of 50-100 μV/m, an overall occurrence rate of ˜0.76% with higher occurrence during active times, and strong correlation with auroral hiss. The magnetic local time distribution of the MF waves observed by DEMETER shows peak occurrence rate near 18 MLT, somewhat earlier than the equivalent peak in the occurrence rate of ground level MF burst, though propagation effects and differences in the latitudes sampled by the two techniques may explain this discrepancy. Analysis of solar wind and SuperMAG data suggests that while the bursty MF waves observed by DEMETER are associated with enhanced auroral activity, their coincidence with substorm onset may not be as exact as that of ground level MF burst. One conjunction occurs in which MF burst is observed at Churchill, Manitoba, within 8 min of MF emissions detected by DEMETER on field lines approximately 1000 km southeast of Churchill. These observations may plausibly be associated with the same auroral event detected by ground level magnetometers at several Canadian observatories. Although it is uncertain, the balance of the evidence suggests that the bursty MF waves observed with DEMETER are the same phenomenon as the ground level MF burst. Hence, theories of MF burst generation in the ionosphere, such as beam-generated Langmuir waves excited over a range of altitudes or strong Langmuir turbulence generating a range of frequencies within a narrow altitude range, need to be revisited to

  4. The future for the Global Sea Level Observing System (GLOSS) Sea Level Data Rescue

    NASA Astrophysics Data System (ADS)

    Bradshaw, Elizabeth; Matthews, Andrew; Rickards, Lesley; Aarup, Thorkild

    2016-04-01

    Historical sea level data are rare and unrepeatable measurements with a number of applications in climate studies (sea level rise), oceanography (ocean currents, tides, surges), geodesy (national datum), geophysics and geology (coastal land movements) and other disciplines. However, long-term time series are concentrated in the northern hemisphere and there are no records at the Permanent Service for Mean Sea Level (PSMSL) global data bank longer than 100 years in the Arctic, Africa, South America or Antarctica. Data archaeology activities will help fill in the gaps in the global dataset and improve global sea level reconstruction. The Global Sea Level Observing System (GLOSS) is an international programme conducted under the auspices of the WMO-IOC Joint Technical Commission for Oceanography and Marine Meteorology. It was set up in 1985 to collect long-term tide gauge observations and to develop systems and standards "for ocean monitoring and flood warning purposes". At the GLOSS-GE-XIV Meeting in 2015, GLOSS agreed on a number of action items to be developed in the next two years. These were: 1. To explore mareogram digitisation applications, including NUNIEAU (more information available at: http://www.mediterranee.cerema.fr/logiciel-de-numerisation-des-enregistrements-r57.html) and other recent developments in scanning/digitisation software, such as IEDRO's Weather Wizards program, to see if they could be used via a browser. 2. To publicise sea level data archaeology and rescue by: • maintaining and regularly updating the Sea Level Data Archaeology page on the GLOSS website • strengthening links to the GLOSS data centres and data rescue organisations e.g. linking to IEDRO, ACRE, RDA • restarting the sea level data rescue blog with monthly posts. 3. Investigate sources of funding for data archaeology and rescue projects. 4. Propose "Guidelines" for rescuing sea level data. These action items will aid the discovery, scanning, digitising and quality control

  5. Variation of radiation level and radionuclide enrichment in high background area.

    PubMed

    Shetty, P K; Narayana, Y

    2010-12-01

    Significantly high radiation level and radionuclide concentration along Quilon beach area of coastal Kerala have been reported by several investigators. Detailed gamma radiation level survey was carried out using a portable scintillometer. Detailed studies on radionuclides concentration in different environmental matrices of high background areas were undertaken in the coastal areas of Karunagapalli, Kayankulam, Chavara, Neendakara and Kollam to study the distribution and enrichment of the radionuclides in the region. The absorbed gamma dose rates in air in high background area are in the range 43-17,400nGyh⁻¹. Gamma radiation level is found to be maximum at a distance of 20m from the sea waterline in all beaches. The soil samples collected from different locations were analysed for primordial radionuclides by gamma spectrometry. The activity of primordial radionuclides was determined for the different size fractions of soil to study the enrichment pattern. The highest activity of (232)Th and (226)Ra was found to be enriched in 125-63μ size fraction. The preferential accumulation of (40)K was found in <63μ fraction. The minimum (232)Th activity was 30.2Bqkg⁻¹, found in 1000-500μ particle size fraction at Kollam and maximum activity of 3250.4Bqkg⁻¹ was observed in grains of size 125-63μ at Neendakara. The lowest (226)Ra activity observed was 33.9Bqkg⁻¹ at Neendakara in grains of size 1000-500μ and the highest activity observed was 482.6Bqkg⁻¹ in grains of size 125-63μ in Neendakara. The highest (40)K activity found was 1923Bqkg⁻¹ in grains of size <63μ for a sample collected from Neendakara. A good correlation was observed between computed dose and measured dose in air. The correlation between (232)Th and (226)Ra was also moderately high. The results of these investigations are presented and discussed in this paper. Copyright © 2010 Elsevier Ltd. All rights reserved.

  6. EEG oscillations entrain their phase to high-level features of speech sound.

    PubMed

    Zoefel, Benedikt; VanRullen, Rufin

    2016-01-01

    Phase entrainment of neural oscillations, the brain's adjustment to rhythmic stimulation, is a central component in recent theories of speech comprehension: the alignment between brain oscillations and speech sound improves speech intelligibility. However, phase entrainment to everyday speech sound could also be explained by oscillations passively following the low-level periodicities (e.g., in sound amplitude and spectral content) of auditory stimulation-and not by an adjustment to the speech rhythm per se. Recently, using novel speech/noise mixture stimuli, we have shown that behavioral performance can entrain to speech sound even when high-level features (including phonetic information) are not accompanied by fluctuations in sound amplitude and spectral content. In the present study, we report that neural phase entrainment might underlie our behavioral findings. We observed phase-locking between electroencephalogram (EEG) and speech sound in response not only to original (unprocessed) speech but also to our constructed "high-level" speech/noise mixture stimuli. Phase entrainment to original speech and speech/noise sound did not differ in the degree of entrainment, but rather in the actual phase difference between EEG signal and sound. Phase entrainment was not abolished when speech/noise stimuli were presented in reverse (which disrupts semantic processing), indicating that acoustic (rather than linguistic) high-level features play a major role in the observed neural entrainment. Our results provide further evidence for phase entrainment as a potential mechanism underlying speech processing and segmentation, and for the involvement of high-level processes in the adjustment to the rhythm of speech. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. HEAO 1 high-energy X-ray observations of Centaurus X-3

    NASA Technical Reports Server (NTRS)

    Howe, S. K.; Primini, F. A.; Bautz, M. W.; Lang, F. L.; Levine, A. M.; Lewin, W. H. G.

    1983-01-01

    Pulsations of 4.8 sec were detected up to energies above 38 keV by the present High Energy X-ray and Low Energy Gamma-Ray HEAO 1 satellite experiment observations of Cen X-3, and an analysis of the X-ray spectrum as a function of pulse phase indicates that the spectrum hardens during an interval of about 1.2 sec which lags the pulse peak by about 0.6 sec. The results of correlated observations of pulse period and X-ray intensity include (1) the detection of a high intensity state during which the pulse period is on the average increasing, (2) the measurement of comparable high intensities during episodes of both period increase and decrease, (3) the detection of X-ray pulsations at a much reduced level during a period of low intensity, and (4) the detection of a transition between spin-down, and spin-up episodes that coincides with a rapid decrease in X-ray intensity.

  8. Levels of Social Play: Observing and Recording Preschoolers.

    ERIC Educational Resources Information Center

    Barbakoff, Sondra; Yo, Yang Pei

    Noting that observing preschool children at play allows teachers to understand how individual children develop their social skills, this article describes different levels of social play and shows how teachers may use a running record and check list to assess such play. Children are described as engaging in onlooker play, solitary play, parallel…

  9. Subseasonal to Seasonal Predictions of U.S. West Coast High Water Levels

    NASA Astrophysics Data System (ADS)

    Khouakhi, A.; Villarini, G.; Zhang, W.; Slater, L. J.

    2017-12-01

    Extreme sea levels pose a significant threat to coastal communities, ecosystems, and assets, as they are conducive to coastal flooding, coastal erosion and inland salt-water intrusion. As sea levels continue to rise, these sea level extremes - including occasional minor coastal flooding experienced during high tide (nuisance floods) - are of concern. Extreme sea levels are increasing at many locations around the globe and have been attributed largely to rising mean sea levels associated with intra-seasonal to interannual climate processes such as the El Niño-Southern Oscillation (ENSO). Here, intra-seasonal to seasonal probabilistic forecasts of high water levels are computed at the Toke Point tide gage station on the US west coast. We first identify the main climate drivers that are responsible for high water levels and examine their predictability using General Circulation Models (GCMs) from the North American Multi-Model Ensemble (NMME). These drivers are then used to develop a probabilistic framework for the seasonal forecasting of high water levels. We focus on the climate controls on the frequency of high water levels using the number of exceedances above the 99.5th percentile and above the nuisance flood level established by the National Weather Service. Our findings indicate good forecast skill at the shortest lead time, with the skill that decreases as we increase the lead time. In general, these models aptly capture the year-to-year variability in the observational records.

  10. Sensitivity of the High Altitude Water Cherenkov Experiment to observe Gamma-Ray Bursts

    NASA Astrophysics Data System (ADS)

    González, M. M.

    Ground based telescopes have marginally observed very high energy emission (>100GeV) from gamma-ray bursts(GRB). For instance, Milagrito observed GRB970417a with a significance of 3.7 sigmas over the background. Milagro have not yet observed TeV emission from a GRB with its triggered and untriggered searches or GeV emission with a triggered search using its scalers. These results suggest the need of new observatories with higher sensitivity to transient sources. The HAWC (High Altitute Water Cherenkov) observatory is proposed as a combination of the Milagro tecnology with a very high altitude (>4000m over see level) site. The expected HAWC sensitivity for GRBs is at least >10 times the Milagro sensitivity. In this work HAWC sensitivity for GRBs is discussed for different detector configurations such as altitude, distance between PMTs, depth under water of PMTs, number of PMTs required for a trigger, etc.

  11. Beneficial effects of fingolimod in MS patients with high serum Sema4A levels.

    PubMed

    Koda, Toru; Namba, Akiko; Nakatsuji, Yuji; Niino, Masaaki; Miyazaki, Yusei; Sugimoto, Tomoyuki; Kinoshita, Makoto; Takata, Kazushiro; Yamashita, Kazuya; Shimizu, Mikito; Fukazawa, Toshiyuki; Kumanogoh, Atsushi; Mochizuki, Hideki; Okuno, Tatsusada

    2018-01-01

    We previously demonstrated that patients with multiple sclerosis (MS) of high serum Sema4A levels are resistant to IFN-β therapy. To further elucidate the role of serum Sema4A as a biomarker for therapeutic stratification in MS patients, it is important to clarify the efficacy of other disease-modifying drugs (DMD) in those with high serum Sema4A levels. Thus, in this study we investigated whether fingolimod has beneficial effects on MS patients with high Sema4A levels. We retrospectively analyzed annualized relapse rate (ARR) and Expanded Disability Status Scale (EDSS) change in 56 relapsing-remitting multiple sclerosis (RRMS) patients who had been treated with fingolimod, including those who switched from IFN-β therapy. The levels of Sema4A in the sera were measured by sandwich ELISA. The implications of Sema4A on the efficacy of fingolimod were investigated by administering recombinant Sema4A-Fc and fingolimod to mice with experimental autoimmune encephalomyelitis (EAE). Retrospective analysis of MS cohort (17 high Sema4A and 39 low Sema4A) demonstrated the effectiveness of fingolimod in those with high serum Sema4A levels, showing reduction of ARR (from 1.21 to 0.12) and EDSS progression (from 0.50 to 0.04). Consistent with this observation, improvement in the disease severity of EAE mice receiving recombinant Sema4A-Fc was also observed after fingolimod treatment. These data suggest that fingolimod could serve as a candidate DMD for managing the disease activity of MS patients with high Sema4A levels.

  12. High-level intuitive features (HLIFs) for intuitive skin lesion description.

    PubMed

    Amelard, Robert; Glaister, Jeffrey; Wong, Alexander; Clausi, David A

    2015-03-01

    A set of high-level intuitive features (HLIFs) is proposed to quantitatively describe melanoma in standard camera images. Melanoma is the deadliest form of skin cancer. With rising incidence rates and subjectivity in current clinical detection methods, there is a need for melanoma decision support systems. Feature extraction is a critical step in melanoma decision support systems. Existing feature sets for analyzing standard camera images are comprised of low-level features, which exist in high-dimensional feature spaces and limit the system's ability to convey intuitive diagnostic rationale. The proposed HLIFs were designed to model the ABCD criteria commonly used by dermatologists such that each HLIF represents a human-observable characteristic. As such, intuitive diagnostic rationale can be conveyed to the user. Experimental results show that concatenating the proposed HLIFs with a full low-level feature set increased classification accuracy, and that HLIFs were able to separate the data better than low-level features with statistical significance. An example of a graphical interface for providing intuitive rationale is given.

  13. An Alternative Approach of Coastal Sea-Level Observation from Remote Sensing Imageries

    NASA Astrophysics Data System (ADS)

    Peng, H. Y.; Tseng, K. H.; Chung-Yen, K.; Lin, T. H.; Liao, W. H.; Chen, C. F.

    2017-12-01

    Coastal sea level can be observed as waterline changes along a coastal digital elevation model (DEM). However, most global DEMs, such as the Shuttle Radar Topography Mission (SRTM) DEM with 30 m resolution, provide limited coverage over coastal area due to the impermeability of radar signal over water and the lack of low-tide coincidence. Therefore, we aim to extend to coverage of SRTM DEM for the determination of intertidal zone and to monitor sea-level changes along the entire coastline of Taiwan (>1200km). We firstly collect historical cloud-free images since the 1980s, including Landsat series, SPOT series and Sentinel-2, and then calculate the Modified Normalized Difference Water Index (MNDWI) to identify water pixels. After computing water appearance probability of each pixel, it is converted into actual elevation by introducing the DTU10 tide model for high tide and low tide boundaries. A coastal DEM of intertidal zone is reconstructed and the accuracy is at 50 cm level as compared with in situ DEM built by an unmanned aerial vehicle (UAV). Finally, we use this product to define the up-to-date intertidal zone and estimate sea-level changes by using remote sensing snapshots.

  14. High vaccination coverage is associated with low epidemic level of seasonal influenza in elementary schools: an observational study in Matsumoto City, Japan.

    PubMed

    Uchida, Mitsuo; Kaneko, Minoru; Hidaka, Yoshihiko; Yamamoto, Hiroshi; Honda, Takayuki; Takeuchi, Shouhei; Saito, Masaya; Kawa, Shigeyuki

    2018-03-13

    Influenza virus transmission may be prevented by infection control measures, including vaccination, wearing a mask, gargling with water, and hand washing. It is unclear, however, whether these measures affect influenza epidemics in school settings. A prospective epidemiological survey in all public elementary schools in Matsumoto City, Japan, during the 2014/2015 season evaluated the number of diagnosed patients in each school and calculated the reproduction number of schoolchildren. At the end of the prospective survey, a cross-sectional survey evaluated the implementation of infection control measures in these schools. Both results were combined and associations among infection control measures including vaccination, mask wearing, hand washing, water gargling, and epidemic level were evaluated. Of the 13,217 schoolchildren in 29 schools, 2548 were diagnosed with seasonal influenza. A significant negative association was observed between vaccination coverage and reproduction number at each school, but not between other infection control measures and the reproduction number. A regression curve with exponential function was most predictive. At 0% vaccination, the reproduction number was estimated to be 1.39. These findings provide evidence that high vaccination coverage was associated with reduced epidemic levels in schools and suggest the need for increased vaccination of schoolchildren.

  15. Low-level awareness accompanies "unconscious" high-level processing during continuous flash suppression.

    PubMed

    Gelbard-Sagiv, Hagar; Faivre, Nathan; Mudrik, Liad; Koch, Christof

    2016-01-01

    The scope and limits of unconscious processing are a matter of ongoing debate. Lately, continuous flash suppression (CFS), a technique for suppressing visual stimuli, has been widely used to demonstrate surprisingly high-level processing of invisible stimuli. Yet, recent studies showed that CFS might actually allow low-level features of the stimulus to escape suppression and be consciously perceived. The influence of such low-level awareness on high-level processing might easily go unnoticed, as studies usually only probe the visibility of the feature of interest, and not that of lower-level features. For instance, face identity is held to be processed unconsciously since subjects who fail to judge the identity of suppressed faces still show identity priming effects. Here we challenge these results, showing that such high-level priming effects are indeed induced by faces whose identity is invisible, but critically, only when a lower-level feature, such as color or location, is visible. No evidence for identity processing was found when subjects had no conscious access to any feature of the suppressed face. These results suggest that high-level processing of an image might be enabled by-or co-occur with-conscious access to some of its low-level features, even when these features are not relevant to the processed dimension. Accordingly, they call for further investigation of lower-level awareness during CFS, and reevaluation of other unconscious high-level processing findings.

  16. Ground-based very high energy gamma ray astronomy: Observational highlights

    NASA Technical Reports Server (NTRS)

    Turver, K. E.

    1986-01-01

    It is now more than 20 years since the first ground based gamma ray experiments involving atmospheric Cerenkov radiation were undertaken. The present highlights in observational ground-based very high energy (VHE) gamma ray astronomy and the optimism about an interesting future for the field follow progress in these areas: (1) the detection at increased levels of confidence of an enlarged number of sources so that at present claims were made for the detection, at the 4 to 5 sd level of significance, of 8 point sources; (2) the replication of the claimed detections with, for the first time, confirmation of the nature and detail of the emission; and (3) the extension of gamma ray astronomy to the ultra high energy (UHE) domain. The pattern, if any, to emerge from the list of sources claimed so far is that X-ray binary sources appear to be copious emitters of gamma rays over at least 4 decades of energy. These X-ray sources which behave as VHE and UHE gamma ray emitters are examined.

  17. A Reliable, Feasible Method to Observe Neighborhoods at High Spatial Resolution

    PubMed Central

    Kepper, Maura M.; Sothern, Melinda S.; Theall, Katherine P.; Griffiths, Lauren A.; Scribner, Richard; Tseng, Tung-Sung; Schaettle, Paul; Cwik, Jessica M.; Felker-Kantor, Erica; Broyles, Stephanie T.

    2016-01-01

    Introduction Systematic social observation (SSO) methods traditionally measure neighborhoods at street level and have been performed reliably using virtual applications to increase feasibility. Research indicates that collection at even higher spatial resolution may better elucidate the health impact of neighborhood factors, but whether virtual applications can reliably capture social determinants of health at the smallest geographic resolution (parcel level) remains uncertain. This paper presents a novel, parcel-level SSO methodology and assesses whether this new method can be collected reliably using Google Street View and is feasible. Methods Multiple raters (N=5) observed 42 neighborhoods. In 2016, inter-rater reliability (observed agreement and kappa coefficient) was compared for four SSO methods: (1) street-level in person; (2) street-level virtual; (3) parcel-level in person; and (4) parcel-level virtual. Intra-rater reliability (observed agreement and kappa coefficient) was calculated to determine whether parcel-level methods produce results comparable to traditional street-level observation. Results Substantial levels of inter-rater agreement were documented across all four methods; all methods had >70% of items with at least substantial agreement. Only physical decay showed higher levels of agreement (83% of items with >75% agreement) for direct versus virtual rating source. Intra-rater agreement comparing street- versus parcel-level methods resulted in observed agreement >75% for all but one item (90%). Conclusions Results support the use of Google Street View as a reliable, feasible tool for performing SSO at the smallest geographic resolution. Validation of a new parcel-level method collected virtually may improve the assessment of social determinants contributing to disparities in health behaviors and outcomes. PMID:27989289

  18. Greenland uplift and regional sea level changes from ICESat observations and GIA modelling

    NASA Astrophysics Data System (ADS)

    Spada, G.; Ruggieri, G.; Sørensen, L. S.; Nielsen, K.; Melini, D.; Colleoni, F.

    2012-06-01

    We study the implications of a recently published mass balance of the Greenland ice sheet (GrIS), derived from repeated surface elevation measurements from NASA's ice cloud and land elevation satellite (ICESat) for the time period between 2003 and 2008. To characterize the effects of this new, high-resolution GrIS mass balance, we study the time-variations of various geophysical quantities in response to the current mass loss. They include vertical uplift and subsidence, geoid height variations, global patterns of sea level change (or fingerprints), and regional sea level variations along the coasts of Greenland. Long-wavelength uplifts and gravity variations in response to current or past ice thickness variations are obtained solving the sea level equation, which accounts for both the elastic and the viscoelastic components of deformation. To capture the short-wavelength components of vertical uplift in response to current ice mass loss, which is not resolved by satellite gravity observations, we have specifically developed a high-resolution regional elastic rebound (ER) model. The elastic component of vertical uplift is combined with estimates of the viscoelastic displacement fields associated with the process of glacial-isostatic adjustment (GIA), according to a set of published ice chronologies and associated mantle rheological profiles. We compare the sensitivity of global positioning system (GPS) observations along the coasts of Greenland to the ongoing ER and GIA. In notable contrast with past reports, we show that vertical velocities obtained by GPS data from five stations with sufficiently long records and from one tide gauge at the GrIS margins can be reconciled with model predictions based on the ICE-5G deglaciation model and the ER associated with the new ICESat-derived mass balance.

  19. 46 CFR 153.409 - High level alarms.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false High level alarms. 153.409 Section 153.409 Shipping... Systems § 153.409 High level alarms. When Table 1 refers to this section or requires a cargo to have a closed gauging system, the cargo's containment system must have a high level alarm: (a) That gives an...

  20. High serum selenium levels are associated with impaired fasting glucose and elevated fasting serum glucose in Linyi, China.

    PubMed

    Li, Zhe; Li, Xia; Ju, Wen; Wu, Guanrui; Yang, Xiaomei; Fu, Xiaofeng; Gao, Xibao

    2018-01-01

    The relationship between selenium level and impaired fasting glucose or elevated fasting serum glucose remains controversial. This study aimed to evaluate these associations in China. This observational population study adopted a cluster sampling approach to enroll participants. Baseline information on selenium categories was tested using one-way analysis of variance and Kruskal-Wallis equality-of-populations rank tests. Multivariable logistic regression was used to investigate the association between serum selenium level and impaired fasting glucose or elevated fasting serum glucose. The mean serum selenium concentration was 121.5μg/L which in a relatively high baseline Se status. Differences were observed among individuals with normal, impaired fasting glucose and elevated fasting serum glucose levels in their basic information, physical examination results and laboratory findings. After adjusting for their basic information, physical examination results and laboratory findings, compared with the low-selenium group, the high-selenium groups (124.9-143.9 and above 143.9μg/L) had ORs for elevated fasting serum glucose of 2.31 (1.37-3.90) and 2.67 (1.59-4.48), respectively (both P<0.05). A sex-difference was observed, and a significant association between selenium levels and impaired fasting glucose was observed for males but not for females. The findings of this observational study suggest that relatively high selenium levels might be positively associated with elevated fasting serum glucose and relatively high selenium levels might be positively associated with impaired fasting glucose in men. Copyright © 2017 Elsevier GmbH. All rights reserved.

  1. Masking of low-frequency signals by high-frequency, high-level narrow bands of noisea

    PubMed Central

    Patra, Harisadhan; Roup, Christina M.; Feth, Lawrence L.

    2011-01-01

    Low-frequency masking by intense high-frequency noise bands, referred to as remote masking (RM), was the first evidence to challenge energy-detection models of signal detection. Its underlying mechanisms remain unknown. RM was measured in five normal-hearing young-adults at 250, 350, 500, and 700 Hz using equal-power, spectrally matched random-phase noise (RPN) and low-noise noise (LNN) narrowband maskers. RM was also measured using equal-power, two-tone complex (TC2) and eight-tone complex (TC8). Maskers were centered at 3000 Hz with one or two equivalent rectangular bandwidths (ERBs). Masker levels varied from 80 to 95 dB sound pressure level in 5 dB steps. LNN produced negligible masking for all conditions. An increase in bandwidth in RPN yielded greater masking over a wider frequency region. Masking for TC2 was limited to 350 and 700 Hz for one ERB but shifted to only 700 Hz for two ERBs. A spread of masking to 500 and 700 Hz was observed for TC8 when the bandwidth was increased from one to two ERBs. Results suggest that high-frequency noise bands at high levels could generate significant low-frequency masking. It is possible that listeners experience significant RM due to the amplification of various competing noises that might have significant implications for speech perception in noise. PMID:21361445

  2. High-Level Data-Abstraction System

    NASA Technical Reports Server (NTRS)

    Fishwick, P. A.

    1986-01-01

    Communication with data-base processor flexible and efficient. High Level Data Abstraction (HILDA) system is three-layer system supporting data-abstraction features of Intel data-base processor (DBP). Purpose of HILDA establishment of flexible method of efficiently communicating with DBP. Power of HILDA lies in its extensibility with regard to syntax and semantic changes. HILDA's high-level query language readily modified. Offers powerful potential to computer sites where DBP attached to DEC VAX-series computer. HILDA system written in Pascal and FORTRAN 77 for interactive execution.

  3. High-level aminoglycoside resistance and virulence characteristics among Enterococci isolated from recreational beaches in Malaysia.

    PubMed

    Dada, Ayokunle Christopher; Ahmad, Asmat; Usup, Gires; Heng, Lee Yook; Hamid, Rahimi

    2013-09-01

    We report the first study on the occurrence of high-level aminoglycoside-resistant (HLAR) Enterococci in coastal bathing waters and beach sand in Malaysia. None of the encountered isolates were resistant to high levels of gentamicin (500 μg/mL). However, high-level resistance to kanamycin (2,000 μg/mL) was observed in 14.2 % of tested isolates, the highest proportions observed being among beach sand isolates. High-level resistance to kanamycin was higher among Enterococcus faecalis and Enterococcus faecium than Enterococcus spp. Chi-square analysis showed no significant association between responses to tested antibiotics and the species allocation or source of isolation of all tested Enterococci. The species classification of encountered Enterococci resistance to vancomycin was highest among Enterococcus spp. (5.89 %) followed by E. faecium (4.785) and least among E. faecalis. A total of 160 isolates were also tested for virulence characteristics. On the whole, caseinase production was profoundly highest (15.01 %) while the least prevalent virulence characteristic observed among tested beach Enterococci was haemolysis of rabbit blood (3.65 %). A strong association was observed between the source of isolation and responses for each of caseinase (C = 0.47, V = 0.53) and slime (C = 0.50, V = 0.58) assays. Analysis of obtained spearman's coefficient showed a strong correlation between caseinase and each of the slime production (p = 0.04), gelatinase (p = 0.0035) and haemolytic activity on horse blood (p = 0.004), respectively. Suggestively, these are the main virulent characteristics of the studied beach Enterococci. Our findings suggest that recreational beaches may contribute to the dissemination of Enterococci with HLAR and virulence characteristics.

  4. Sea level measurements using multi-frequency GPS and GLONASS observations

    NASA Astrophysics Data System (ADS)

    Löfgren, Johan S.; Haas, Rüdiger

    2014-12-01

    Global Positioning System (GPS) tide gauges have been realized in different configurations, e.g., with one zenith-looking antenna, using the multipath interference pattern for signal-to-noise ratio (SNR) analysis, or with one zenith- and one nadir-looking antenna, analyzing the difference in phase delay, to estimate the sea level height. In this study, for the first time, we use a true Global Navigation Satellite System (GNSS) tide gauge, installed at the Onsala Space Observatory. This GNSS tide gauge is recording both GPS and Globalnaya Navigatsionnaya Sputnikovaya Sistema (GLONASS) signals and makes it possible to use both the one- and two-antenna analysis approach. Both the SNR analysis and the phase delay analysis were evaluated using dual-frequency GPS and GLONASS signals, i.e., frequencies in the L-band, during a 1-month-long campaign. The GNSS-derived sea level results were compared to independent sea level observations from a co-located pressure tide gauge and show a high correlation for both systems and frequency bands, with correlation coefficients of 0.86 to 0.97. The phase delay results show a better agreement with the tide gauge sea level than the SNR results, with root-mean-square differences of 3.5 cm (GPS L1 and L2) and 3.3/3.2 cm (GLONASS L1/L2 bands) compared to 4.0/9.0 cm (GPS L1/L2) and 4.7/8.9 cm (GLONASS L1/L2 bands). GPS and GLONASS show similar performance in the comparison, and the results prove that for the phase delay analysis, it is possible to use both frequencies, whereas for the SNR analysis, the L2 band should be avoided if other signals are available. Note that standard geodetic receivers using code-based tracking, i.e., tracking the un-encrypted C/A-code on L1 and using the manufacturers' proprietary tracking method for L2, were used. Signals with the new C/A-code on L2, the so-called L2 C , were not tracked. Using wind speed as an indicator for sea surface roughness, we find that the SNR analysis performs better in rough sea

  5. High altitude observations of Birkeland currents

    NASA Technical Reports Server (NTRS)

    Russell, C. T.

    1977-01-01

    Several models of field-aligned currents (Birkeland currents) in the magnetosphere are discussed, and high altitude observations of these currents, carried out with the aid of highly eccentric earth-orbiting spacecraft of the OGO and IMP series, are reviewed. The essential roles of Birkeland currents are identified: they relieve charge imbalances, transmit stresses, and lead to particle acceleration anomalous resistivity.

  6. Combination of Vlbi, GPS and Slr Observations At The Observation Level For The Realization of Terrestrial and Celestial Reference Frames

    NASA Astrophysics Data System (ADS)

    Andersen, P. H.

    Forsvarets forskningsinstitutt (FFI, the Norwegian Defence Research Establishment) has during the last 17 years developed a software system called GEOSAT, for the analysis of any type of high precision space geodetic observations. A unique feature of GEOSAT is the possibility of combining any combination of different space geode- tic data at the observation level with one consistent model and one consistent strategy. This is a much better strategy than the strategy in use today where different types of observations are processed separately using analysis software developed specifically for each technique. The results from each technique are finally combined a posteriori. In practice the models implemented in the software packages differ at the 1-cm level which is almost one order of magnitude larger than the internal precision of the most precise techniques. Another advantage of the new proposed combination method is that for example VLBI and GPS can use the same tropospheric model with common parameterization. The same is the case for the Earth orientation parameters, the geo- center coordinates and other geodetic or geophysical parameters where VLBI, GPS and SLR can have a common estimate for each of the parameters. The analysis with GEOSAT is automated for the combination of VLBI, SLR and GPS observations. The data are analyzed in batches of one day where the result from each daily arc is a SRIF array (Square Root Information Filter). A large number of SRIF arrays can be combined into a multi-year solution using the CSRIFS program (Com- bination Square Root Information Filter and Smoother). Four parameter levels are available and any parameter can, at each level, either be represented as a constant or a stochastic parameter (white noise, colored noise, or random walk). The batch length (i.e. the time interval between the addition of noise to the SRIF array) can be made time- and parameter dependent. GEOSAT and CSRIFS have been applied in the analysis of selected

  7. Thz and Long Path Fourier Transform Spectroscopy of Methanol; Torsionally Coupled High-K Levels

    NASA Astrophysics Data System (ADS)

    Pearson, John C.; Yu, Shanshan; Drouin, Brian J.; Lees, Ronald M.; Xu, Li-Hong; Billinghurst, Brant E.

    2012-06-01

    Methanol is nearly ubiquitous in the interstellar gas. The presence of both a-type and b-type dipole moments, asymmetry, and internal rotation assure that any small astronomical observation window will contain multiple methanol transitions. This often allows a great deal about the local physical conditions to be deduced, but only insofar as the spectra are characterized. The Herschel Space Observatory has detected numerous, clearly beam diluted, methanol transitions with quanta surpassing J = 35 in many regions. Unfortunately, observations of methanol often display strong non-thermal behavior whose modeling requires many additional levels to be included in a radiative transfer analysis. Additionally, the intensities of many more highly excited transitions are strongly dependent on the accuracy of the wave functions used in the calculation. We report a combined Fourier Transform Infrared and THz study targeting the high J and K transitions in the ground torsional manifold. Microwave accuracy energy levels have been derived to J > 40 and K as high as 20. These levels illuminate a number of strongly resonant torsional interactions that dominate the high K spectrum of the molecule. Comparison with levels calculated from the rho-axis method Hamiltonian suggest that the rho-axis method should be able to model v_t = 0, 1 and probably v_t = 2 to experimental accuracy. The challenges in determining methanol wave functions to experimental accuracy will be discussed.

  8. Network-based high level data classification.

    PubMed

    Silva, Thiago Christiano; Zhao, Liang

    2012-06-01

    Traditional supervised data classification considers only physical features (e.g., distance or similarity) of the input data. Here, this type of learning is called low level classification. On the other hand, the human (animal) brain performs both low and high orders of learning and it has facility in identifying patterns according to the semantic meaning of the input data. Data classification that considers not only physical attributes but also the pattern formation is, here, referred to as high level classification. In this paper, we propose a hybrid classification technique that combines both types of learning. The low level term can be implemented by any classification technique, while the high level term is realized by the extraction of features of the underlying network constructed from the input data. Thus, the former classifies the test instances by their physical features or class topologies, while the latter measures the compliance of the test instances to the pattern formation of the data. Our study shows that the proposed technique not only can realize classification according to the pattern formation, but also is able to improve the performance of traditional classification techniques. Furthermore, as the class configuration's complexity increases, such as the mixture among different classes, a larger portion of the high level term is required to get correct classification. This feature confirms that the high level classification has a special importance in complex situations of classification. Finally, we show how the proposed technique can be employed in a real-world application, where it is capable of identifying variations and distortions of handwritten digit images. As a result, it supplies an improvement in the overall pattern recognition rate.

  9. The global coastline dataset: the observed relation between erosion and sea-level rise

    NASA Astrophysics Data System (ADS)

    Donchyts, G.; Baart, F.; Luijendijk, A.; Hagenaars, G.

    2017-12-01

    Erosion of sandy coasts is considered one of the key risks of sea-level rise. Because sandy coastlines of the world are often highly populated, erosive coastline trends result in risk to populations and infrastructure. Most of our understanding of the relation between sea-level rise and coastal erosion is based on local or regional observations and generalizations of numerical and physical experiments. Until recently there was no reliable global scale assessment of the location of sandy coasts and their rate of erosion and accretion. Here we present the global coastline dataset that covers erosion indicators on a local scale with global coverage. The dataset uses our global coastline transects grid defined with an alongshore spacing of 250 m and a cross shore length extending 1 km seaward and 1 km landward. This grid matches up with pre-existing local grids where available. We present the latest results on validation of coastal-erosion trends (based on optical satellites) and classification of sandy versus non-sandy coasts. We show the relation between sea-level rise (based both on tide-gauges and multi-mission satellite altimetry) and observed erosion trends over the last decades, taking into account broken-coastline trends (for example due to nourishments).An interactive web application presents the publicly-accessible results using a backend based on Google Earth Engine. It allows both researchers and stakeholders to use objective estimates of coastline trends, particularly when authoritative sources are not available.

  10. Observations Of General Learning Patterns In An Upper-Level Thermal Physics Course

    NASA Astrophysics Data System (ADS)

    Meltzer, David E.

    2009-11-01

    I discuss some observations from using interactive-engagement instructional methods in an upper-level thermal physics course over a two-year period. From the standpoint of the subject matter knowledge of the upper-level students, there was a striking persistence of common learning difficulties previously observed in students enrolled in the introductory course, accompanied, however, by some notable contrasts between the groups. More broadly, I comment on comparisons and contrasts regarding general pedagogical issues among different student sub-populations, for example: differences in the receptivity of lower- and upper-level students to diagrammatic representations; varying receptivity to tutorial-style instructional approach within the upper-level population; and contrasting approaches to learning among physics and engineering sub-populations in the upper-level course with regard to use of symbolic notation, mathematical equations, and readiness to employ verbal explanations.

  11. 91. World War II observation post, Cabarello level looking from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    91. World War II observation post, Cabarello level looking from Carmen Bastion (similar to HABS PR-48-24) - Castillo de San Felipe del Morro, Northwest end of San Juan, San Juan, San Juan Municipio, PR

  12. Water levels in observation wells in Nebraska during 1955

    USGS Publications Warehouse

    Keech, C.F.

    1956-01-01

    The objective of the dbservation-well program in Nebraska is to provide an evaluation of the status of the ground-water supplies. Many uses for water-.level data are known but not all potential uses can be forseen. Among the important uses are the following:To indicate the status of ground water in storage or in transit and the availability of supplies.To show the trend of ground-water supplies and the outlook for the future.To estimate or forcast the base flow of streams.To indicate areas in which the water level is approaching too close to the land surface (water-logging) or is receding toward economic limits of lift or tow rd impairment by water of poor quality.To provide long-term vidence for evaluating the effectiveness of land-management and water...0 nservation programs in relation to water conservation actually of ected, and for use in basin or "watershed" studies.To provide longterm ontinuous records to serve as a framework to which short-term records collected during intensive investigation may be related.The water level in an observation well functions as a gage to indicate the position of the water table o The water table is defined as the upper surface of the zone of saturation except where that surface is formed by overlying impermeable materials. The water table is also the boundary between the zone of saturation and the zone of aeration. It is not a level surface but is a sloping surface that has many irregularities, and it often conforms in a general way to the land surface. The irregularities are caused by several factors. In places where the recharge to the ground-water reservoir is exceptionally large, the water-table may rise to form a mound from which the water slowly spreads. Depressions or troughs in the water table indicate places where the ground water is discharging, as along streams that are below the normal level of the water table, or indicate places where water is being withdrawn by wells or vegetation.The several factors that

  13. High intensity interval training vs. high-volume running training during pre-season conditioning in high-level youth football: a cross-over trial.

    PubMed

    Faude, Oliver; Schnittker, Reinhard; Schulte-Zurhausen, Roman; Müller, Florian; Meyer, Tim

    2013-01-01

    We aimed at comparing the endurance effects of high-intensity interval training (HIIT) with high-volume running training (HVT) during pre-season conditioning in 20 high-level youth football players (15.9 (s 0.8) years). Players either conducted HVT or HIIT during the summer preparation period. During winter preparation they performed the other training programme. Before and after each training period several fitness tests were conducted: multi-stage running test (to assess the individual anaerobic threshold (IAT) and maximal running velocity (Vmax)), vertical jumping height, and straight sprinting. A significant increase from pre- to post-test was observed in IAT velocity (P < 0.001) with a greater increase after HVT (+0.8 km · h(-1) vs. +0.5 km · h(-1) after HIIT, P = 0.04). Maximal velocity during the incremental exercise test also slightly increased with time (P = 0.09). Forty per cent (HIIT) and 15% (HVT) of all players did not improve IAT beyond baseline variability. The players who did not respond to HIIT were significantly slower during 30 m sprinting than responders (P = 0.02). No further significant differences between responders and non-responders were observed. Jump heights deteriorated significantly after both training periods (P < 0.003). Both training programmes seem to be promising means to improve endurance capacity in high-level youth football players during pre-season conditioning.

  14. Do we understand high-level vision?

    PubMed

    Cox, David Daniel

    2014-04-01

    'High-level' vision lacks a single, agreed upon definition, but it might usefully be defined as those stages of visual processing that transition from analyzing local image structure to analyzing structure of the external world that produced those images. Much work in the last several decades has focused on object recognition as a framing problem for the study of high-level visual cortex, and much progress has been made in this direction. This approach presumes that the operational goal of the visual system is to read-out the identity of an object (or objects) in a scene, in spite of variation in the position, size, lighting and the presence of other nearby objects. However, while object recognition as a operational framing of high-level is intuitive appealing, it is by no means the only task that visual cortex might do, and the study of object recognition is beset by challenges in building stimulus sets that adequately sample the infinite space of possible stimuli. Here I review the successes and limitations of this work, and ask whether we should reframe our approaches to understanding high-level vision. Copyright © 2014. Published by Elsevier Ltd.

  15. Coronal Heating and the Need for High-Resolution Observations

    NASA Technical Reports Server (NTRS)

    Klimchuk, James A.

    2008-01-01

    Despite excellent progress in recent years in understanding coronal heating, there remain many crucial questions that are still unanswered. Limitations in the observations are one important reason. Both theoretical and observational considerations point to the importance of small spatial scales, impulsive energy release, strong dynamics, and extreme plasma nonuniformity. As a consequence, high spatial resolution, broad temperature coverage, high temperature fidelity, and sensitivity to velocities and densities are all critical observational parameters. Current instruments lack one or more of these properties, and this has led to considerable ambiguity and confusion. In this talk, I will discuss recent ideas about coronal heating and emphasize that high spatial resolution observations, especially spectroscopic observations, are needed to make major progress on this important problem.

  16. Serum irisin and myostatin levels after 2 weeks of high-altitude climbing.

    PubMed

    Śliwicka, Ewa; Cisoń, Tomasz; Kasprzak, Zbigniew; Nowak, Alicja; Pilaczyńska-Szcześniak, Łucja

    2017-01-01

    Exposure to high-altitude hypoxia causes physiological and metabolic adaptive changes by disturbing homeostasis. Hypoxia-related changes in skeletal muscle affect the closely interconnected energy and regeneration processes. The balance between protein synthesis and degradation in the skeletal muscle is regulated by several molecules such as myostatin, cytokines, vitamin D, and irisin. This study investigates changes in irisin and myostatin levels in male climbers after a 2-week high-altitude expedition, and their association with 25(OH)D and indices of inflammatory processes. The study was performed in 8 men aged between 23 and 31 years, who participated in a 2-week climbing expedition in the Alps. The measurements of body composition and serum concentrations of irisin, myostatin, 25(OH)D, interleukin-6, myoglobin, high-sensitivity C-reactive protein, osteoprotegerin, and high-sensitivity soluble receptor activator of NF-κB ligand (sRANKL) were performed before and after expedition. A 2-week exposure to hypobaric hypoxia caused significant decrease in body mass, body mass index (BMI), free fat mass and irisin, 25-Hydroxyvitamin D levels. On the other hand, significant increase in the levels of myoglobin, high-sensitivity C-reactive protein, interleukin-6, and osteoprotegerin were noted. The observed correlations of irisin with 25(OH)D levels, as well as myostatin levels with inflammatory markers and the OPG/RANKL ratio indicate that these myokines may be involved in the energy-related processes and skeletal muscle regeneration in response to 2-week exposure to hypobaric hypoxia.

  17. NIOZ high-resolution moored temperature observations: benefits and new challenges.

    NASA Astrophysics Data System (ADS)

    Cimatoribus, Andrea; Gostiaux, Louis; Cyr, Frederic; van Haren, Hans

    2016-04-01

    The Royal Netherlands Institute for Sea Research has been developing for several years a family of temperature sensors (NIOZ1 to NIOZ5). In the latest iterations of this project, these instruments are precise (10-3 K or better), have a very low noise level (below 10-3 K), are relatively fast (sampling rate of 1Hz) and can measure for extended periods of time (several months). Being also compact and lightweight, several thermistors can be attached on a single line at a fine vertical spacing (20cm or more). When mounted on a cable, the instruments are all synchronised to a single clock, thus providing simultaneous measurements throughout the depth range of the mooring (usually in the order of 100m). Recently, the instruments have also been deployed in a group of 5 lines approximately 5m apart from each other, providing a unique view on the three-dimensional temperature field. After almost 10 years of successful deployments at sea, we try to draw some conclusions from this effort, from the scientific and technical point of view. This observational system provides temperature measurements with vertical spatial resolution comparable to that of microstructure profilers, but in comparison to ship-borne systems it offers some distinctive features: providing instantaneous measurements throughout the mooring, observations of waves and overturning structures are not influenced by the time delay between measurements at different depths; the very low noise level and high precision enables the study of the deep, weakly stratified ocean; by using a heavy ballast at the bottom and a high net buoyancy at the top of the mooring, Eulerian measurements are effectively obtained; continuous, high sampling rate Eulerian measurements enable to assess the intermittent, sporadic nature of turbulence and wave activity in the ocean; the large range of time scales included in the observations (100 - 106 s) allows to study a large portion of the turbulence inertial range, the full internal wave

  18. Creative thinking level of students with high capability in relations and functions by problem-based learning

    NASA Astrophysics Data System (ADS)

    Nurdyani, F.; Slamet, I.; Sujadi, I.

    2018-03-01

    This research was conducted in order to describe the creative thinking level of students with high capability in relations and functions with Problem Based Learning. The subjects of the research were students with high capability grade VIII at SMPIT Ibnu Abbas Klaten. This research is an qualitative descriptive research. The data were collected using observation, tests and interviews. The result showed that the creative thinking level of students with high capability in relations and functions by Problem Based Learning was at level 4 or very creative because students were able to demonstrate fluency, flexibility, and novelty.

  19. Observations and a linear model of water level in an interconnected inlet-bay system

    NASA Astrophysics Data System (ADS)

    Aretxabaleta, Alfredo L.; Ganju, Neil K.; Butman, Bradford; Signell, Richard P.

    2017-04-01

    A system of barrier islands and back-barrier bays occurs along southern Long Island, New York, and in many coastal areas worldwide. Characterizing the bay physical response to water level fluctuations is needed to understand flooding during extreme events and evaluate their relation to geomorphological changes. Offshore sea level is one of the main drivers of water level fluctuations in semienclosed back-barrier bays. We analyzed observed water levels (October 2007 to November 2015) and developed analytical models to better understand bay water level along southern Long Island. An increase (˜0.02 m change in 0.17 m amplitude) in the dominant M2 tidal amplitude (containing the largest fraction of the variability) was observed in Great South Bay during mid-2014. The observed changes in both tidal amplitude and bay water level transfer from offshore were related to the dredging of nearby inlets and possibly the changing size of a breach across Fire Island caused by Hurricane Sandy (after December 2012). The bay response was independent of the magnitude of the fluctuations (e.g., storms) at a specific frequency. An analytical model that incorporates bay and inlet dimensions reproduced the observed transfer function in Great South Bay and surrounding areas. The model predicts the transfer function in Moriches and Shinnecock bays where long-term observations were not available. The model is a simplified tool to investigate changes in bay water level and enables the evaluation of future conditions and alternative geomorphological settings.

  20. Observations and a linear model of water level in an interconnected inlet-bay system

    USGS Publications Warehouse

    Aretxabaleta, Alfredo; Ganju, Neil K.; Butman, Bradford; Signell, Richard

    2017-01-01

    A system of barrier islands and back-barrier bays occurs along southern Long Island, New York, and in many coastal areas worldwide. Characterizing the bay physical response to water level fluctuations is needed to understand flooding during extreme events and evaluate their relation to geomorphological changes. Offshore sea level is one of the main drivers of water level fluctuations in semienclosed back-barrier bays. We analyzed observed water levels (October 2007 to November 2015) and developed analytical models to better understand bay water level along southern Long Island. An increase (∼0.02 m change in 0.17 m amplitude) in the dominant M2 tidal amplitude (containing the largest fraction of the variability) was observed in Great South Bay during mid-2014. The observed changes in both tidal amplitude and bay water level transfer from offshore were related to the dredging of nearby inlets and possibly the changing size of a breach across Fire Island caused by Hurricane Sandy (after December 2012). The bay response was independent of the magnitude of the fluctuations (e.g., storms) at a specific frequency. An analytical model that incorporates bay and inlet dimensions reproduced the observed transfer function in Great South Bay and surrounding areas. The model predicts the transfer function in Moriches and Shinnecock bays where long-term observations were not available. The model is a simplified tool to investigate changes in bay water level and enables the evaluation of future conditions and alternative geomorphological settings.

  1. 7. BULLET GLASS OBSERVATION WINDOW AT GROUND LEVEL ON WEST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. BULLET GLASS OBSERVATION WINDOW AT GROUND LEVEL ON WEST REAR. - Edwards Air Force Base, South Base Sled Track, Firing & Control Blockhouse for 10,000-foot Track, South of Sled Track at midpoint of 20,000-foot track, Lancaster, Los Angeles County, CA

  2. Observed Evolution of the Upper-level Thermal Structure in Tropical Cyclones

    NASA Astrophysics Data System (ADS)

    Rivoire, L.; Birner, T.; Knaff, J. A.

    2016-12-01

    Tropical cyclones (TCs) are associated with tropopause-level cooling above the well-known tropospheric warm core. While the investigation of tropopause-level structures started as early as 1951, there is no clear consensus on the mechanisms involved. In addition, the large-scale average vertical and radial structure of the tropopause-level cooling is yet to be examined. Tropopause-level cooling destabilizes the upper atmosphere to convection, which potentially allows existing convection to reach higher altitudes. This is of particular importance during the early stages of tropical cyclogenesis. Other important characteristics of the tropopause-level cooling include its amplitude, its position relative to that of the warm core, its radial extent, and its evolution during the lifetime of TCs. These potentially influence TC structure, surface pressure gradients and maximum winds, intensity evolution, and outflow entropy. We use the 322 hurricane-strength TCs from the best-track archive in 2007-2014, along with high vertical resolution temperature measurements from the Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC). These measurements are composited about the Lifetime Maximum Intensity (LMI) to examine the evolution of the fine-scale upper-level thermal structure inside TCs. We find that the tropopause-cooling has an amplitude similar to that of the warm core. Relative to the far-field structure (the area average between 1300-1500 km radii), tropopause-level cooling is found to occur several days before the warm core is established. Cold anomalies extend up to 1000 km away from the storm center, and may take part in a large-scale poleward transport of cold, dry air in the UTLS. Lastly, cold air masses move away from the storm center (and warm core) after LMI, and their remains lie around the 400-700 km radius -essentially inward of the radius of maximum tangential anticyclonic winds in the outflow layer. We discuss these results in the

  3. Exploring Options for an Integrated Water Level Observation Network in Alaska

    NASA Astrophysics Data System (ADS)

    McCammon, M.

    2016-02-01

    Portions' of Alaska's remote coastlines are among the Nation's most vulnerable to geohazards such as tsunami, extra-tropical storm surge, and erosion; and the availability of observations of water levels, ocean waves, and river discharge are severely lacking to support water level warnings and forecasts. Alaska is experiencing dramatic reductions in sea ice cover, changes in extra-tropical storm surge patterns, and thawing permafrost. These conditions are endangering coastal populations throughout the State. Gaps in the ocean observing system limit our State's ability to provide useful marine and sea ice forecasts, especially in the Arctic. A spectrum of observation platforms may provide an optimal solution for filling the most critical gaps in these coastal and ocean areas. The collaborations described in this talk and better leveraging of resources and capabilities across federal, state, and academic partners will provide the best opportunity for advancing our science capacity and capabilities in this remote region.

  4. High-level penicillin resistance and penicillin-gentamicin synergy in Enterococcus faecium.

    PubMed Central

    Torres, C; Tenorio, C; Lantero, M; Gastañares, M J; Baquero, F

    1993-01-01

    Thirty-seven Enterococcus faecium strains with different levels of penicillin susceptibility were studied in time-kill experiments with a fixed concentration (5 micrograms/ml) of gentamicin combined with different penicillin concentrations (6 to 600 micrograms/ml). Synergy was defined as a relative decrease in counts of greater than 2 log10 CFU per milliliter after 24 h of incubation when the combination of the antibiotics was compared with its most active component alone. The minimal synergistic penicillin concentrations found were 6 micrograms/ml for 16 of 16 strains for which penicillin MICs were < or = 25 micrograms/ml, 20 to 100 micrograms/ml for 14 of 17 strains for which penicillin MICs were 50 to 200 micrograms/ml, and 200 to 500 micrograms/ml for 4 of 4 strains for which MICs penicillin were > 200 micrograms/ml. Penicillin-gentamicin synergy was observed even in high-level penicillin-resistant E. faecium strains at penicillin concentrations close to one-half the penicillin MIC. The possibility of treating infections caused by high-level penicillin-resistant E. faecium strains with penicillin-gentamicin combinations in particular cases may depend on the penicillin levels attainable in vivo. PMID:8285628

  5. 46 CFR 182.530 - Bilge high level alarms.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Bilge high level alarms. 182.530 Section 182.530... TONS) MACHINERY INSTALLATION Bilge and Ballast Systems § 182.530 Bilge high level alarms. (a) On a... operating station to indicate a high water level in each of the following normally unmanned spaces: (1) A...

  6. Rapid Ice-Sheet Changes and Mechanical Coupling to Solid-Earth/Sea-Level and Space Geodetic Observation

    NASA Astrophysics Data System (ADS)

    Adhikari, S.; Ivins, E. R.; Larour, E. Y.

    2015-12-01

    Perturbations in gravitational and rotational potentials caused by climate driven mass redistribution on the earth's surface, such as ice sheet melting and terrestrial water storage, affect the spatiotemporal variability in global and regional sea level. Here we present a numerically accurate, computationally efficient, high-resolution model for sea level. Unlike contemporary models that are based on spherical-harmonic formulation, the model can operate efficiently in a flexible embedded finite-element mesh system, thus capturing the physics operating at km-scale yet capable of simulating geophysical quantities that are inherently of global scale with minimal computational cost. One obvious application is to compute evolution of sea level fingerprints and associated geodetic and astronomical observables (e.g., geoid height, gravity anomaly, solid-earth deformation, polar motion, and geocentric motion) as a companion to a numerical 3-D thermo-mechanical ice sheet simulation, thus capturing global signatures of climate driven mass redistribution. We evaluate some important time-varying signatures of GRACE inferred ice sheet mass balance and continental hydrological budget; for example, we identify dominant sources of ongoing sea-level change at the selected tide gauge stations, and explain the relative contribution of different sources to the observed polar drift. We also report our progress on ice-sheet/solid-earth/sea-level model coupling efforts toward realistic simulation of Pine Island Glacier over the past several hundred years.

  7. 46 CFR 119.530 - Bilge high level alarms.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Bilge high level alarms. 119.530 Section 119.530... Bilge and Ballast Systems § 119.530 Bilge high level alarms. (a) Each vessel must be provided with a visual and audible alarm at the operating station to indicate a high water level in each of the following...

  8. Observation of high-energy gamma rays from the quasi-stellar object CTA 102

    NASA Technical Reports Server (NTRS)

    Nolan, P. L.; Bertsch, D. L.; Fichtel, C. E.; Hartman, R. C.; Hunter, S. D.; Kanbach, G.; Kniffen, D. A.; Lin, Y. C.; Mattox, J. R.; Mayer-Hasselwander, H. A.

    1993-01-01

    The quasar CTA 102 (QSO 2230 + 114) was observed four times in 1991-1992 by the EGRET high-energy gamma-ray telescope on the Compton GRO satellite. In the 1992 January 23-February 6 observation, emission was detected at the level (2.4 +/- 0.5) x 10 exp 7 photons/sq cm s (E is greater than 100 MeV). The other observations produced upper limits or detections with lower significance which are consistent with the same flux. The photon spectrum can be represented by a power law with a number index of 2.6 +/- 0.2, the softest so far observed by EGRET. The emitted gamma-ray luminosity, if isotropic, is 5 x 10 exp 47 ergs/s (H(0) = 75 km/s Mpc , q(0) = 0.5), although there are good reasons to believe that the gamma emission is strongly beamed.

  9. Basal cortisol levels and metabolic syndrome: A systematic review and meta-analysis of observational studies.

    PubMed

    Garcez, Anderson; Leite, Heloísa Marquardt; Weiderpass, Elisabete; Paniz, Vera Maria Vieira; Watte, Guilherme; Canuto, Raquel; Olinto, Maria Teresa Anselmo

    2018-05-17

    To perform a qualitative synthesis (systematic review) and quantitative analysis (meta-analysis) to summarize the evidence regarding the relationship between basal cortisol levels and metabolic syndrome (MetS) in adults. A systematic search was performed in the PubMed, Embase, and PsycINFO databases for observational studies on the association between basal cortisol levels and MetS. The quality of individual studies was assessed by the Newcastle-Ottawa score. A random effects model was used to report pooled quantitative results and the I 2 statistic was used to assess heterogeneity. Egger's and Begg's tests were used to evaluate publication bias. Twenty-six studies (19 cross-sectional and seven case-control) met the inclusion criteria for the systematic review. The majority was classified as having a low risk of bias and used established criteria for the diagnosis of MetS. Twenty-one studies provided data on basal cortisol levels as continuous values and were included in the meta-analysis; they comprised 35 analyses and 11,808 subjects. Pooled results showed no significant difference in basal cortisol levels between subjects with and without MetS (standardized mean difference [SMD] = 0.02, 95% confidence interval [CI]=-0.11 to 0.14). There was high heterogeneity between the studies when all comparisons were considered (I 2  = 83.1%;p < 0.001). Paradoxically, meta-analysis of studies evaluating saliva samples showed no significantly lower basal cortisol levels among subjects with MetS (SMD=-0.18, 95% CI=-0.37 to 0.01), whereas those studies that evaluated serum samples (SMD = 0.11, 95% CI=-0.02 to 0.24) and urine samples (SMD = 0.73, 95% CI=-0.40 to 1.86) showed no significantly higher basal cortisol levels among subjects with MetS. In the subgroup and meta-regression analyses, a significant difference in basal cortisol levels was observed according to study design, population base, age, gender, cortisol level assessment method, and study quality

  10. Predictors of Placement in Lower Level versus Higher Level High School Mathematics

    ERIC Educational Resources Information Center

    Archbald, Doug; Farley-Ripple, Elizabeth N.

    2012-01-01

    Educators and researchers have long been interested in determinants of access to honors level and college prep courses in high school. Factors influencing access to upper level mathematics courses are particularly important because of the hierarchical and sequential nature of this subject and because students who finish high school with only lower…

  11. High temperature plasma in beta Lyrae, observed from Copernicus

    NASA Technical Reports Server (NTRS)

    Kondo, Y.; Hack, M.; Hutchings, J. B.; Mccluskey, G. E., Jr.; Plavec, M.; Polidan, R. S.

    1975-01-01

    High-resolution UV spectrophotometry of the complex close binary system beta Lyrae was performed with a telescope spectrometer on board Copernicus. Observations were made at phases 0.0, 0.25, 0.5, and 0.75 with resolutions of 0.2 A (far-UV) and 0.4 A (mid-UV). The far-UV spectrum is completely dominated by emission lines indicating the existence of a high-temperature plasma in this binary. The spectrum of this object is unlike that of any other object observed from Copernicus. It is believed that this high-temperature plasma results from dynamic mass transfer taking place in the binary. The current results are compared with OAO-2 observations and other observational results. The possibility that the secondary component is a collapsed object is also discussed; the Copernicus observations are consistent with the hypothesis that the spectroscopically invisible secondary component is a black hole.

  12. High levels of Porphyromonas gingivalis-induced immunoglobulin G2 are associated with lower high-density lipoprotein levels in chronic periodontitis.

    PubMed

    Ardila, Carlos M; Guzmán, Isabel C

    2016-11-01

    To investigate the association between the presence of Porphyromonas gingivalis-induced immunoglobulin G antibodies and the high-density lipoprotein (HDL) level. A total of 108 individuals were examined. The presence of P. gingivalis was detected using primers designed to target the 16S rRNA gene sequence. Peripheral blood was collected from each subject to determine the levels of P. gingivalis-induced IgG1 and IgG2 serum antibodies. The HDL levels were determined using fully enzymatic methods. A higher proportion of periodontitis patients had high levels of P. gingivalis-induced IgG1 and IgG2, and the proportion of subjects with a HDL level of < 35 md/dL was higher in the group of chronic periodontitis patients. In the unadjusted regression model, the presence of high levels of P. gingivalis-induced IgG2 was associated with a HDL level of < 35 md/dL. The adjusted model indicated that periodontitis patients with high levels of P. gingivalis-induced IgG2 showed 3.2 more chances of having pathological HDL levels (odds ratio = 3.2, 95% confidence interval = 1.2-9.8). High levels of P. gingivalis-induced IgG2 were associated with low HDL concentrations in patients with periodontitis, which suggests that the response of the host to periodontal infection may play an important role in the pathogenesis of cardiovascular diseases. © 2015 Wiley Publishing Asia Pty Ltd.

  13. High Resolution Active Optics Observations from the Kepler Follow-up Observation Program

    NASA Astrophysics Data System (ADS)

    Gautier, Thomas N.; Ciardi, D. R.; Marcy, G. W.; Hirsch, L.

    2014-01-01

    The ground based follow-up observation program for candidate exoplanets discovered with the Kepler observatory has supported a major effort for high resolution imaging of candidate host stars using adaptive optics wave-front correction (AO), speckle imaging and lucky imaging. These images allow examination of the sky as close as a few tenths of an arcsecond from the host stars to detect background objects that might be the source of the Kepler transit signal instead of the host star. This poster reports on the imaging done with AO cameras on the Keck, Palomar 5m and Shane 3m (Lick Observatory) which have been used to obtain high resolution images of over 500 Kepler Object of Interest (KOI) exoplanet candidate host stars. All observations were made at near infrared wavelengths in the J, H and K bands, mostly using the host target star as the AO guide star. Details of the sensitivity to background objects actually attained by these observations and the number of background objects discovered are presented. Implications to the false positive rate of the Kepler candidates are discussed.

  14. Observation of Landau levels on nitrogen-doped flat graphite surfaces without external magnetic fields

    PubMed Central

    Kondo, Takahiro; Guo, Donghui; Shikano, Taishi; Suzuki, Tetsuya; Sakurai, Masataka; Okada, Susumu; Nakamura, Junji

    2015-01-01

    Under perpendicular external magnetic fields, two-dimensional carriers exhibit Landau levels (LLs). However, it has recently been reported that LLs have been observed on graphene and graphite surfaces without external magnetic fields being applied. These anomalous LLs have been ascribed primarily to a strain of graphene sheets, leading to in-plane hopping modulation of electrons. Here, we report the observation of the LLs of massive Dirac fermions on atomically flat areas of a nitrogen-doped graphite surface in the absence of external magnetic fields. The corresponding magnetic fields were estimated to be as much as approximately 100 T. The generation of the LLs at the area with negligible strain can be explained by inequivalent hopping of π electrons that takes place at the perimeter of high-potential domains surrounded by positively charged substituted graphitic-nitrogen atoms. PMID:26549618

  15. High-Level Radioactive Waste.

    ERIC Educational Resources Information Center

    Hayden, Howard C.

    1995-01-01

    Presents a method to calculate the amount of high-level radioactive waste by taking into consideration the following factors: the fission process that yields the waste, identification of the waste, the energy required to run a 1-GWe plant for one year, and the uranium mass required to produce that energy. Briefly discusses waste disposal and…

  16. Correlation of low levels of nitrite and high levels of fetal hemoglobin in patients with sickle cell disease at baseline

    PubMed Central

    Elias, Darcielle Bruna Dias; Rocha, Lilianne Brito da Silva; Cavalcante, Maritza Barbosa; Pedrosa, Alano Martins; Justino, Izabel Cristina Bandeira; Gonçalves, Romélia Pinheiro

    2012-01-01

    Background Sickle cell disease is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and recurrent vaso-occlusive crises that reduces the quality of life of sufferers. Objective To evaluate the correlation of the levels of lactate dehydrogenase, malonaldehyde and nitrite to fetal hemoglobin in patients with sickle cell disease not under treatment with hydroxyurea in outpatients at a university hospital in Fortaleza, Ceará, Brazil. Methods Forty-four patients diagnosed with sickle cell disease were enrolled at baseline. Diagnosis was confirmed by evaluating the beta globin gene using polymerase chain reaction-restriction fragment length polymorphism. The concentration of fetal hemoglobin was obtained by high-performance liquid chromatography. Serum levels of nitrite, malonaldehyde and lactate dehydrogenase were measured by biochemical methods. Results Significantly higher levels of lactate dehydrogenase, nitrite and malonaldehyde were observed in patients with sickle cell disease compared to a control group. The study of the correlation between fetal hemoglobin levels and these variables showed a negative correlation with nitrite levels. No correlation was found between fetal hemoglobin and malonaldehyde or lactate dehydrogenase. When the study population was stratified according to fetal hemoglobin levels, a decrease in the levels of nitrite was observed with higher levels of fetal hemoglobin (p-value = 0.0415). Conclusion The results show that, similar to fetal hemoglobin levels, the concentration of nitrite can predict the clinical course of the disease, but should not be used alone as a modulator of prognosis in patients with sickle cell disease. PMID:23049438

  17. EUVE GO Survey: High Levels of User Satisfaction

    NASA Astrophysics Data System (ADS)

    Stroozas, B. A.

    2000-12-01

    This paper describes the results of a detailed customer survey of Guest Observers (GOs) for NASA's Extreme Ultraviolet Explorer (EUVE) astronomy satellite observatory. The purpose of the research survey was to (1) measure the levels of GO customer satisfaction with respect to EUVE observing services, and (2) compare the observing experiences of EUVE GOs with their experiences using other satellite observatories. This survey was conducted as a business research project -- part of the author's graduate work as an MBA candidate. A total sample of 38 respondents, from a working population of 101 "active" EUVE GOs, participated in this survey. The results, which provided a profile of the "typical" EUVE GO, showed in a statistically significant fashion that these GOs were more than satisfied with the available EUVE observing services. In fact, the sample GOs generally rated their EUVE observing experiences to be better than average as compared to their experiences as GOs on other missions. These relatively high satisfaction results are particularly pleasing to the EUVE Project which, given its significantly reduced staffing environment at U.C. Berkeley, has continued to do more with less. This paper outlines the overall survey process: the relevant background and previous research, the survey design and methodology, and the final results and their interpretation. The paper also points out some general limitations and weaknesses of the study, along with some recommended actions for the EUVE Project and for NASA in general. This work was funded by NASA/UCB Cooperative Agreement NCC5-138.

  18. Process for solidifying high-level nuclear waste

    DOEpatents

    Ross, Wayne A.

    1978-01-01

    The addition of a small amount of reducing agent to a mixture of a high-level radioactive waste calcine and glass frit before the mixture is melted will produce a more homogeneous glass which is leach-resistant and suitable for long-term storage of high-level radioactive waste products.

  19. Terrestrial laser scanning observations of geomorphic changes and varying lava lake levels at Erebus volcano, Antarctica

    NASA Astrophysics Data System (ADS)

    Jones, Laura K.; Kyle, Philip R.; Oppenheimer, Clive; Frechette, Jedediah D.; Okal, Marianne H.

    2015-03-01

    A Terrestrial Laser Scanning (TLS) instrument was used to image the topography of the Main Crater at Erebus volcano each December in 2008, 2009, and 2010. Our high-spatial resolution TLS scans provide unique insights into annual and decadal scale geomorphic evolution of the summit area when integrated with comparable data collected by an airborne instrument in 2001. We observe both a pattern of subsidence within the Inner Crater of the volcano and an ~ 3 m per-year drop in the lava lake level over the same time period that are suggestive of decreasing overpressure in an underlying magma reservoir. We also scanned the active phonolite lava lake hosted within the Inner Crater, and recorded rapid cyclic fluctuations in the level of the lake. These were sporadically interrupted by minor explosions by bursting gas bubbles at the lake surface. The TLS data permit calculation of lake level rise and fall speeds and associated rates of volumetric change within the lake. These new observations, when considered with prior determinations of rates of lake surface motion and gas output, are indicative of unsteady magma flow in the conduit and its associated variability in gas volume fraction.

  20. Comparison between SAGE II and ISCCP high-level clouds. 2: Locating clouds tops

    NASA Technical Reports Server (NTRS)

    Liao, Xiaohan; Rossow, William B.; Rind, David

    1995-01-01

    A comparison is made of the vertical distribution of high-level cloud tops derived from the Stratospheric Aerosol and Gas Experiment II (SAGE II) occultation measurements and from the International Satellite Cloud Climatology Project (ISCCP) for all Julys and Januarys in 1985 to 1990. The results suggest that ISCCP overestimates the pressure of high-level clouds by up to 50-150 mbar, particularly at low latitudes. This is caused by the frequent presence of clouds with diffuse tops (greater than 50% time when cloudy events are observed). The averaged vertical extent of the diffuse top is about 1.5 km. At midlatitudes where the SAGE II and ISCCP cloud top pressure agree best, clouds with distinct tops reach a maximum relative proportion of the total level cloud amount (about 30-40%), and diffuse-topped clouds are reduced to their minimum (30-40%). The ISCCP-defined cloud top pressure should be regarded not as the material physical height of the clouds but as the level which emits the same infrared radiance as observed. SAGE II and ISCCP cloud top pressures agree for clouds with distinct tops. There is also an indication that the cloud top pressures of optically thin clouds not overlying thicker clouds are poorly estimated by ISCCP at middle latitudes. The average vertical extent of these thin clouds is about 2.5 km.

  1. Observing the Great Plains Low-Level Jet Using the Aircraft Communications Addressing and Reporting System (ACARS): A Comparison with Boundary Layer Profiler Observations

    NASA Astrophysics Data System (ADS)

    Skinner, P. S.; Basu, S.

    2009-12-01

    Wind resources derived from the nocturnal low-level jet of the Great Plains of the United States are a driving factor in the proliferation of wind energy facilities across the region. Accurate diagnosis and forecasting of the low-level jet is important to not only assess the wind resource but to estimate the potential for shear-induced stress generation on turbine rotors. This study will examine the utility of Aircraft Communications Addressing and Reporting System (ACARS) observations in diagnosing low-level jet events across the Texas Panhandle. ACARS observations from Lubbock International Airport (KLBB) will be compared to observations from a 915 MHZ Doppler radar vertical boundary-layer profiler with 60m vertical resolution located at the field experiment site of Texas Tech University. The ability of ACARS data to adequately observe low-level jet events during the spring and summer of 2009 will be assessed and presented.

  2. Associations of group level popularity with observed behavior and influence in a dyadic context.

    PubMed

    Lansu, Tessa A M; Cillessen, Antonius H N

    2015-12-01

    This study examined the association between popularity in the peer group and adolescents' behavior in a dyadic context. After collecting peer nominations for popularity, 218 early adolescents (M(age) = 11.0 years) in 109 randomly composed same-sex dyads participated in a discussion task where they planned a party for their classroom. From digital recordings of the sessions, each participant's influence, involvement, skillful leadership, coercive resource control, submissiveness, positivity, and negativity were observed. Analyses with the actor-partner interdependence model (APIM) demonstrated that for girls high group level popularity was associated with a socially sensitive interaction style and influence in the dyadic context. For both boys and girls, the interaction partner's group level popularity negatively predicted their use of coercive resource control strategies and negative behavior in the dyad. For girls, in addition, the interaction partner's group level popularity also positively predicted their submissiveness and negatively predicted their task influence. These results indicate that, in particular for girls, adolescents' group level popularity plays an important role in the behavior of both peers in a cooperative dyadic context. Copyright © 2015 Elsevier Inc. All rights reserved.

  3. High levels of circulating triiodothyronine induce plasma cell differentiation.

    PubMed

    Bloise, Flavia Fonseca; Oliveira, Felipe Leite de; Nobrega, Alberto Félix; Vasconcellos, Rita; Cordeiro, Aline; Paiva, Luciana Souza de; Taub, Dennis D; Borojevic, Radovan; Pazos-Moura, Carmen Cabanelas; Mello-Coelho, Valéria de

    2014-03-01

    The effects of hyperthyroidism on B-cell physiology are still poorly known. In this study, we evaluated the influence of high-circulating levels of 3,5,3'-triiodothyronine (T3) on bone marrow, blood, and spleen B-cell subsets, more specifically on B-cell differentiation into plasma cells, in C57BL/6 mice receiving daily injections of T3 for 14 days. As analyzed by flow cytometry, T3-treated mice exhibited increased frequencies of pre-B and immature B-cells and decreased percentages of mature B-cells in the bone marrow, accompanied by an increased frequency of blood B-cells, splenic newly formed B-cells, and total CD19(+)B-cells. T3 administration also promoted an increase in the size and cellularity of the spleen as well as in the white pulp areas of the organ, as evidenced by histological analyses. In addition, a decreased frequency of splenic B220(+) cells correlating with an increased percentage of CD138(+) plasma cells was observed in the spleen and bone marrow of T3-treated mice. Using enzyme-linked immunospot assay, an increased number of splenic immunoglobulin-secreting B-cells from T3-treated mice was detected ex vivo. Similar results were observed in mice immunized with hen egg lysozyme and aluminum adjuvant alone or together with treatment with T3. In conclusion, we provide evidence that high-circulating levels of T3 stimulate plasma cytogenesis favoring an increase in plasma cells in the bone marrow, a long-lived plasma cell survival niche. These findings indicate that a stimulatory effect on plasma cell differentiation could occur in untreated patients with Graves' disease.

  4. A Framework for Translating a High Level Security Policy into Low Level Security Mechanisms

    NASA Astrophysics Data System (ADS)

    Hassan, Ahmed A.; Bahgat, Waleed M.

    2010-01-01

    Security policies have different components; firewall, active directory, and IDS are some examples of these components. Enforcement of network security policies to low level security mechanisms faces some essential difficulties. Consistency, verification, and maintenance are the major ones of these difficulties. One approach to overcome these difficulties is to automate the process of translation of high level security policy into low level security mechanisms. This paper introduces a framework of an automation process that translates a high level security policy into low level security mechanisms. The framework is described in terms of three phases; in the first phase all network assets are categorized according to their roles in the network security and relations between them are identified to constitute the network security model. This proposed model is based on organization based access control (OrBAC). However, the proposed model extend the OrBAC model to include not only access control policy but also some other administrative security policies like auditing policy. Besides, the proposed model enables matching of each rule of the high level security policy with the corresponding ones of the low level security policy. Through the second phase of the proposed framework, the high level security policy is mapped into the network security model. The second phase could be considered as a translation of the high level security policy into an intermediate model level. Finally, the intermediate model level is translated automatically into low level security mechanism. The paper illustrates the applicability of proposed approach through an application example.

  5. 40 CFR 227.30 - High-level radioactive waste.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false High-level radioactive waste. 227.30 Section 227.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING...-level radioactive waste. High-level radioactive waste means the aqueous waste resulting from the...

  6. Measuring Students' Physical Activity Levels: Validating SOFIT for Use with High-School Students

    ERIC Educational Resources Information Center

    van der Mars, Hans; Rowe, Paul J.; Schuldheisz, Joel M.; Fox, Susan

    2004-01-01

    This study was conducted to validate the System for Observing Fitness Instruction Time (SOFIT) for measuring physical activity levels of high-school students. Thirty-five students (21 girls and 14 boys from grades 9-12) completed a standardized protocol including lying, sitting, standing, walking, running, curl-ups, and push-ups. Heart rates and…

  7. Internal curvature signal and noise in low- and high-level vision

    PubMed Central

    Grabowecky, Marcia; Kim, Yee Joon; Suzuki, Satoru

    2011-01-01

    How does internal processing contribute to visual pattern perception? By modeling visual search performance, we estimated internal signal and noise relevant to perception of curvature, a basic feature important for encoding of three-dimensional surfaces and objects. We used isolated, sparse, crowded, and face contexts to determine how internal curvature signal and noise depended on image crowding, lateral feature interactions, and level of pattern processing. Observers reported the curvature of a briefly flashed segment, which was presented alone (without lateral interaction) or among multiple straight segments (with lateral interaction). Each segment was presented with no context (engaging low-to-intermediate-level curvature processing), embedded within a face context as the mouth (engaging high-level face processing), or embedded within an inverted-scrambled-face context as a control for crowding. Using a simple, biologically plausible model of curvature perception, we estimated internal curvature signal and noise as the mean and standard deviation, respectively, of the Gaussian-distributed population activity of local curvature-tuned channels that best simulated behavioral curvature responses. Internal noise was increased by crowding but not by face context (irrespective of lateral interactions), suggesting prevention of noise accumulation in high-level pattern processing. In contrast, internal curvature signal was unaffected by crowding but modulated by lateral interactions. Lateral interactions (with straight segments) increased curvature signal when no contextual elements were added, but equivalent interactions reduced curvature signal when each segment was presented within a face. These opposing effects of lateral interactions are consistent with the phenomena of local-feature contrast in low-level processing and global-feature averaging in high-level processing. PMID:21209356

  8. Manual cleaning of hospital mattresses: an observational study comparing high- and low-resource settings.

    PubMed

    Hopman, J; Hakizimana, B; Meintjes, W A J; Nillessen, M; de Both, E; Voss, A; Mehtar, S

    2016-01-01

    Hospital-associated infections (HAIs) are more frequently encountered in low- than in high-resource settings. There is a need to identify and implement feasible and sustainable approaches to strengthen HAI prevention in low-resource settings. To evaluate the biological contamination of routinely cleaned mattresses in both high- and low-resource settings. In this two-stage observational study, routine manual bed cleaning was evaluated at two university hospitals using adenosine triphosphate (ATP). Standardized training of cleaning personnel was achieved in both high- and low-resource settings. Qualitative analysis of the cleaning process was performed to identify predictors of cleaning outcome in low-resource settings. Mattresses in low-resource settings were highly contaminated prior to cleaning. Cleaning significantly reduced biological contamination of mattresses in low-resource settings (P < 0.0001). After training, the contamination observed after cleaning in both the high- and low-resource settings seemed comparable. Cleaning with appropriate type of cleaning materials reduced the contamination of mattresses adequately. Predictors for mattresses that remained contaminated in a low-resource setting included: type of product used, type of ward, training, and the level of contamination prior to cleaning. In low-resource settings mattresses were highly contaminated as noted by ATP levels. Routine manual cleaning by trained staff can be as effective in a low-resource setting as in a high-resource setting. We recommend a multi-modal cleaning strategy that consists of training of domestic services staff, availability of adequate time to clean beds between patients, and application of the correct type of cleaning products. Copyright © 2015 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

  9. Using Aoristic Analysis to Link Remote and Ground-Level Phenological Observations

    NASA Astrophysics Data System (ADS)

    Henebry, G. M.

    2013-12-01

    Phenology is about observing events in time and space. With the advent of publically accessible geospatial datastreams and easy to use mapping software, specifying where an event occurs is much less of a challenge than it was just two decades ago. In contrast, specifying when an event occurs remains a nontrivial function of a population of organismal responses, sampling interval, compositing period, and reporting precision. I explore how aoristic analysis can be used to analyzing spatiotemporal events for which the location is known to acceptable levels of precision but for which temporal coordinates are poorly specified or only partially bounded. Aoristic analysis was developed in the late 1990s in the field of quantitative criminology to leverage temporally imprecise geospatial data of crime reports. Here I demonstrate how aoristic analysis can be used to link remotely sensed observations of land surface phenology to ground-level observations of organismal phenophase transitions. Explicit representation of the windows of temporal uncertainty with aoristic weights enables cross-validation exercises and forecasting efforts to avoid false precision.

  10. Effect of citizen engagement levels in flood forecasting by assimilating crowdsourced observations in hydrological models

    NASA Astrophysics Data System (ADS)

    Mazzoleni, Maurizio; Cortes Arevalo, Juliette; Alfonso, Leonardo; Wehn, Uta; Norbiato, Daniele; Monego, Martina; Ferri, Michele; Solomatine, Dimitri

    2017-04-01

    In the past years, a number of methods have been proposed to reduce uncertainty in flood prediction by means of model updating techniques. Traditional physical observations are usually integrated into hydrological and hydraulic models to improve model performances and consequent flood predictions. Nowadays, low-cost sensors can be used for crowdsourced observations. Different type of social sensors can measure, in a more distributed way, physical variables such as precipitation and water level. However, these crowdsourced observations are not integrated into a real-time fashion into water-system models due to their varying accuracy and random spatial-temporal coverage. We assess the effect in model performance due to the assimilation of crowdsourced observations of water level. Our method consists in (1) implementing a Kalman filter into a cascade of hydrological and hydraulic models. (2) defining observation errors depending on the type of sensor either physical or social. Randomly distributed errors are based on accuracy ranges that slightly improve according to the citizens' expertise level. (3) Using a simplified social model to realistically represent citizen engagement levels based on population density and citizens' motivation scenarios. To test our method, we synthetically derive crowdsourced observations for different citizen engagement levels from a distributed network of physical and social sensors. The observations are assimilated during a particular flood event occurred in the Bacchiglione catchment, Italy. The results of this study demonstrate that sharing crowdsourced water level observations (often motivated by a feeling of belonging to a community of friends) can help in improving flood prediction. On the other hand, a growing participation of individual citizens or weather enthusiasts sharing hydrological observations in cities can help to improve model performance. This study is a first step to assess the effects of crowdsourced observations in

  11. High-resolution monitoring of marine protists based on an observation strategy integrating automated on-board filtration and molecular analyses

    NASA Astrophysics Data System (ADS)

    Metfies, Katja; Schroeder, Friedhelm; Hessel, Johanna; Wollschläger, Jochen; Micheller, Sebastian; Wolf, Christian; Kilias, Estelle; Sprong, Pim; Neuhaus, Stefan; Frickenhaus, Stephan; Petersen, Wilhelm

    2016-11-01

    Information on recent biomass distribution and biogeography of photosynthetic marine protists with adequate temporal and spatial resolution is urgently needed to better understand the consequences of environmental change for marine ecosystems. Here we introduce and review a molecular-based observation strategy for high-resolution assessment of these protists in space and time. It is the result of extensive technology developments, adaptations and evaluations which are documented in a number of different publications, and the results of the recently completed field testing which are introduced in this paper. The observation strategy is organized at four different levels. At level 1, samples are collected at high spatiotemporal resolution using the remotely controlled automated filtration system AUTOFIM. Resulting samples can either be preserved for later laboratory analyses, or directly subjected to molecular surveillance of key species aboard the ship via an automated biosensor system or quantitative polymerase chain reaction (level 2). Preserved samples are analyzed at the next observational levels in the laboratory (levels 3 and 4). At level 3 this involves molecular fingerprinting methods for a quick and reliable overview of differences in protist community composition. Finally, selected samples can be used to generate a detailed analysis of taxonomic protist composition via the latest next generation sequencing technology (NGS) at level 4. An overall integrated dataset of the results based on the different analyses provides comprehensive information on the diversity and biogeography of protists, including all related size classes. At the same time the cost of the observation is optimized with respect to analysis effort and time.

  12. A critical state model for mudrock behavior at high stress levels

    NASA Astrophysics Data System (ADS)

    Heidari, M.; Nikolinakou, M. A.; Flemings, P. B.

    2016-12-01

    Recent experimental work has documented that the compression behavior, friction angle, and lateral stress ratio (k0) of mudrocks vary over the stress range of 1 to 100 MPa. We integrate these observations into a critical state model. The internal friction angle and the slope of the compression curve are key parameters in a mudrock critical state model. Published models assume that these parameters do not depend on the stress level, and hence predict lateral stress and normalized strength ratios that do not change with the stress level. However, recent experimental data on resedimented mudrock samples from Eugene Island, Gulf of Mexico, demonstrate that all these parameters vary considerably with the stress level (Casey and Germaine, 2013; Casey et al., 2015). To represent these variations, we develop an enhanced critical state model that uses a stress-level-dependent friction angle and a curvilinear compression curve. We show that this enhanced model predicts the observed variations of the lateral stress and strength ratios. The successful performance of our model indicates that the critical state theory developed for soil can predict mudrock nonlinear behavior at high stress levels and thus can be used in modeling geologic systems. Casey, B., Germaine, J., 2013. Stress Dependence of Shear Strength in Fine-Grained Soils and Correlations with Liquid Limit. J. Geotech. Geoenviron. Eng. 139, 1709-1717. Casey, B., Germaine, J., Flemings, P.B., Fahy, B.P., 2015. Estimating horizontal stresses for mudrocks under one-dimensional compression. Mar. Pet. Geol. 65, 178-186.

  13. The effects of time-varying observation errors on semi-empirical sea-level projections

    DOE PAGES

    Ruckert, Kelsey L.; Guan, Yawen; Bakker, Alexander M. R.; ...

    2016-11-30

    Sea-level rise is a key driver of projected flooding risks. The design of strategies to manage these risks often hinges on projections that inform decision-makers about the surrounding uncertainties. Producing semi-empirical sea-level projections is difficult, for example, due to the complexity of the error structure of the observations, such as time-varying (heteroskedastic) observation errors and autocorrelation of the data-model residuals. This raises the question of how neglecting the error structure impacts hindcasts and projections. Here, we quantify this effect on sea-level projections and parameter distributions by using a simple semi-empirical sea-level model. Specifically, we compare three model-fitting methods: a frequentistmore » bootstrap as well as a Bayesian inversion with and without considering heteroskedastic residuals. All methods produce comparable hindcasts, but the parametric distributions and projections differ considerably based on methodological choices. In conclusion, our results show that the differences based on the methodological choices are enhanced in the upper tail projections. For example, the Bayesian inversion accounting for heteroskedasticity increases the sea-level anomaly with a 1% probability of being equaled or exceeded in the year 2050 by about 34% and about 40% in the year 2100 compared to a frequentist bootstrap. These results indicate that neglecting known properties of the observation errors and the data-model residuals can lead to low-biased sea-level projections.« less

  14. The effects of time-varying observation errors on semi-empirical sea-level projections

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ruckert, Kelsey L.; Guan, Yawen; Bakker, Alexander M. R.

    Sea-level rise is a key driver of projected flooding risks. The design of strategies to manage these risks often hinges on projections that inform decision-makers about the surrounding uncertainties. Producing semi-empirical sea-level projections is difficult, for example, due to the complexity of the error structure of the observations, such as time-varying (heteroskedastic) observation errors and autocorrelation of the data-model residuals. This raises the question of how neglecting the error structure impacts hindcasts and projections. Here, we quantify this effect on sea-level projections and parameter distributions by using a simple semi-empirical sea-level model. Specifically, we compare three model-fitting methods: a frequentistmore » bootstrap as well as a Bayesian inversion with and without considering heteroskedastic residuals. All methods produce comparable hindcasts, but the parametric distributions and projections differ considerably based on methodological choices. In conclusion, our results show that the differences based on the methodological choices are enhanced in the upper tail projections. For example, the Bayesian inversion accounting for heteroskedasticity increases the sea-level anomaly with a 1% probability of being equaled or exceeded in the year 2050 by about 34% and about 40% in the year 2100 compared to a frequentist bootstrap. These results indicate that neglecting known properties of the observation errors and the data-model residuals can lead to low-biased sea-level projections.« less

  15. Suzaku Observations of Luminous Quasars: Revealing the Nature of High-Energy Blazar Emission in Low-level activity States

    DOE PAGES

    Abdo, A. A.; Ackermann, M.; Ajello, M.; ...

    2010-05-21

    We present the results from the Suzaku X-ray observations of five flat-spectrum radio quasars (FSRQs), namely PKS 0208–512, Q 0827+243, PKS 1127–145, PKS 1510–089, and 3C 454.3. Here, all these sources were additionally monitored simultaneously or quasi-simultaneously by the Fermi satellite in gamma rays and the Swift UVOT in the UV and optical bands, respectively. Here, we constructed their broadband spectra covering the frequency range from 10 14 Hz up to 10 25 Hz, and those reveal the nature of high-energy emission of luminous blazars in their low-activity states. The analyzed X-ray spectra are well fitted by a power-law modelmore » with photoelectric absorption. In the case of PKS 0208–512, PKS 1127–145, and 3C 454.3, the X-ray continuum showed indication of hardening at low energies. Moreover, when compared with the previous X-ray observations, we see a significantly increasing contribution of low-energy photons to the total X-ray fluxes when the sources are getting fainter. The same behavior can be noted in the Suzaku data alone. A likely explanation involves a variable, flat-spectrum component produced via inverse-Compton emission, plus an additional, possibly steady soft X-ray component prominent when the source gets fainter. This soft X-ray excess is represented either by a steep power-law (photon indices Γ ~ 3-5) or a blackbody-type emission with temperatures kT ~ 0.1-0.2 keV. We model the broadband spectra of the five observed FSRQs using synchrotron self-Compton and/or external-Compton radiation models. Lastly, our modeling suggests that the difference between the low- and high-activity states in luminous blazars is due to the different total kinetic power of the jet, most likely related to varying bulk Lorentz factor of the outflow within the blazar emission zone.« less

  16. Echo 2 - Observations at Fort Churchill of a 4-keV peak in low-level electron precipitation

    NASA Technical Reports Server (NTRS)

    Arnoldy, R. L.; Hendrickson, R. A.; Winckler, J. R.

    1975-01-01

    The Echo 2 rocket flight launched from Fort Churchill, Manitoba, offered the opportunity to observe high-latitude low-level electron precipitation during quiet magnetic conditions. Although no visual aurora was evident at the time of the flight, an auroral spectrum sharply peaked at a few keV was observed to have intensities from 1 to 2 orders of magnitude lower than peaked spectra typically associated with bright auroral forms. There is a growing body of evidence that relates peaked electron spectra to discrete aurora. The Echo 2 observations show that whatever the mechanism for peaking the electron spectrum in and above discrete forms, it operates over a range of precipitation intensities covering nearly 3 orders of magnitude down to subvisual or near subvisual events.

  17. Observations of Highly Variable Deuterium in the Martian Upper Atmosphere

    NASA Astrophysics Data System (ADS)

    Clarke, John T.; Mayyasi-Matta, Majd A.; Bhattacharyya, Dolon; Chaufray, Jean-Yves; Chaffin, Michael S.; Deighan, Justin; Schneider, Nicholas M.; Jain, Sonal; Jakosky, Bruce

    2017-10-01

    One of the key pieces of evidence for historic high levels of water on Mars is the present elevated ratio of deuterium/hydrogen (D/H) in near-surface water. This can be explained by the loss of large amounts of water into space, with the lighter H atoms escaping faster than D atoms. Understanding the specific physical processes and controlling factors behind the present escape of H and D is the key objective of the MAVEN IUVS echelle channel. This knowledge can then be applied to an accurate extrapolation back in time to understand the water history of Mars. Observations of D in the martian upper atmosphere over the first martian year of the MAVEN mission have shown highly variable amounts of D, with a short-lived maximum just after perihelion and during southern summer. The timing and nature of this increase provide constraints on its possible origin. These results will be presented and compared with other measurements of the upper atmosphere of Mars.

  18. High Sensitive Scintillation Observations At Very Low Frequencies

    NASA Astrophysics Data System (ADS)

    Konovalenko, A. A.; Falkovich, I. S.; Kalinichenko, N. N.; Olyak, M. R.; Lecacheux, A.; Rosolen, C.; Bougeret, J.-L.; Rucker, H. O.; Tokarev, Yu.

    The observation of interplanetary scintillations of compact radio sources is powerful method of solar wind diagnostics. This method is developed mainly at decimeter- meter wavelengths. New possibilities are opened at extremely low frequencies (decameter waves) especially at large elongations. Now this approach is being actively developed using high effective decameter antennas UTR-2, URAN and Nancay Decameter Array. New class of back-end facility like high dynamic range, high resolution digital spectral processors, as well as dynamic spectra determination ideology give us new opportunities for distinguishing of the ionospheric and interplanetary scintillations and for observations of large number of radio sources, whith different angular sizes and elongations, even for the cases of rather weak objects.

  19. Impact of metformin treatment and swimming exercise on visfatin levels in high-fat-induced obesity rats.

    PubMed

    Gao, Ya; Wang, Changjiang; Pan, Tianrong; Luo, Li

    2014-02-01

    Visfatin is a recently discovered adipocytokine that contributes to glucose and obesity-related conditions. Until now, its responses to the insulin-sensitizing agent metformin and to exercise are largely unknown. We aim to investigate the impact of metformin treatment and/or swimming exercise on serum visfatin and visfatin levels in subcutaneous adipose tissue (SAT), peri-renal adipose tissue (PAT) and skeletal muscle (SM) of high-fat-induced obesity rats. Sprague-Dawley rats were fed a normal diet or a high-fat diet for 16 weeks to develop obesity model. The high-fat-induced obesity model rats were then randomized to metformin (MET), swimming exercise (SWI), or adjunctive therapy of metformin and swimming exercise (MAS), besides high-fat obesity control group and a normal control group, all with 10 rats per group. Zoometric and glycemic parameters, lipid profile, and serum visfatin levels were assessed at baseline and after 6 weeks of therapy. Visfatin levels in SAT, PAT and SM were determined by Western Blot. Metformin and swimming exercise improved lipid profile, and increased insulin sensitivity and body weight reduction were observed. Both metformin and swimming exercise down-regulated visfatin levels in SAT and PAT, while the adjunctive therapy conferred greater benefits, but no changes of visfatin levels were observed in SM. Our results indicate that visfatin down-regulation in SAT and PAT may be one of the mechanisms by which metformin and swimming exercise inhibit obesity.

  20. Associations between 25-hydroxyvitamin D levels and pregnancy outcomes: a prospective observational study in southern China.

    PubMed

    Zhou, J; Su, L; Liu, M; Liu, Y; Cao, X; Wang, Z; Xiao, H

    2014-08-01

    Observational studies relating 25-hydroxyvitamin D (25(OH)D) and pregnancy outcomes have reported conflicting results. The aim was to assess maternal 25(OH)D status and its association with pregnancy outcomes. A prospective observational study was carried out in Guangzhou city (23 ºN), China. Pregnant women (n=2960) and healthy controls (n=100) were recruited at a teaching hospital. Maternal 25(OH)D levels were measured at 16-20-week gestation. The pregnant women, if met inclusion and exclusion criteria, were enrolled in further analysis for pregnancy outcomes (n=1953). Mean serum 25(OH)D in pregnant women was 27.03±7.92 ng/ml. In total, 18.9 and 48.6% of pregnant women had low (25(OH)D less than or equal to 20 ng/ml) and medium level (25(OH)D 21-29 ng/ml) of vitamin D, respectively. 25(OH)D was highest in summer and lowest in winter, which showed a positive correlation with temperature (R=0.942) and calcium (R=0.074). Most maternal outcomes (premature rupture of membranes break, polyhydramnios, oligohydramnios, pre-eclampsia, cesarean section), fetal outcomes (spontaneous abortions, medically induced labor, fetal death, fetal distress, fetal growth restriction) and neonatal outcomes (malformations, birth weight and height, low birth weight, macrosomia, small-for-gestational age, score of Apgar 1',5', asphyxia of newborn) were not significantly different between groups, but prevalence of gestational diabetes (adjusted odds ratio (OR) 1.017; 95% confidence interval (CI) 1.002-1.033) and preterm delivery (adjusted OR 1.038; 95% CI 1.018-1.059) in high level group (25(OH)D ⩾30 ng/ml) was higher than that in low and medium level groups. The prevalence of low level of vitamin D (serum 25OHD ⩽20 ng/ml) was 18.9% among pregnant women in southern China. There were no significant differences in most adverse pregnancy outcomes among pregnant women with different levels of vitamin D at 16-20-week gestation except for higher prevalence of gestational diabetes

  1. Visual perception as retrospective Bayesian decoding from high- to low-level features.

    PubMed

    Ding, Stephanie; Cueva, Christopher J; Tsodyks, Misha; Qian, Ning

    2017-10-24

    When a stimulus is presented, its encoding is known to progress from low- to high-level features. How these features are decoded to produce perception is less clear, and most models assume that decoding follows the same low- to high-level hierarchy of encoding. There are also theories arguing for global precedence, reversed hierarchy, or bidirectional processing, but they are descriptive without quantitative comparison with human perception. Moreover, observers often inspect different parts of a scene sequentially to form overall perception, suggesting that perceptual decoding requires working memory, yet few models consider how working-memory properties may affect decoding hierarchy. We probed decoding hierarchy by comparing absolute judgments of single orientations and relative/ordinal judgments between two sequentially presented orientations. We found that lower-level, absolute judgments failed to account for higher-level, relative/ordinal judgments. However, when ordinal judgment was used to retrospectively decode memory representations of absolute orientations, striking aspects of absolute judgments, including the correlation and forward/backward aftereffects between two reported orientations in a trial, were explained. We propose that the brain prioritizes decoding of higher-level features because they are more behaviorally relevant, and more invariant and categorical, and thus easier to specify and maintain in noisy working memory, and that more reliable higher-level decoding constrains less reliable lower-level decoding. Published under the PNAS license.

  2. Visual perception as retrospective Bayesian decoding from high- to low-level features

    PubMed Central

    Ding, Stephanie; Cueva, Christopher J.; Tsodyks, Misha; Qian, Ning

    2017-01-01

    When a stimulus is presented, its encoding is known to progress from low- to high-level features. How these features are decoded to produce perception is less clear, and most models assume that decoding follows the same low- to high-level hierarchy of encoding. There are also theories arguing for global precedence, reversed hierarchy, or bidirectional processing, but they are descriptive without quantitative comparison with human perception. Moreover, observers often inspect different parts of a scene sequentially to form overall perception, suggesting that perceptual decoding requires working memory, yet few models consider how working-memory properties may affect decoding hierarchy. We probed decoding hierarchy by comparing absolute judgments of single orientations and relative/ordinal judgments between two sequentially presented orientations. We found that lower-level, absolute judgments failed to account for higher-level, relative/ordinal judgments. However, when ordinal judgment was used to retrospectively decode memory representations of absolute orientations, striking aspects of absolute judgments, including the correlation and forward/backward aftereffects between two reported orientations in a trial, were explained. We propose that the brain prioritizes decoding of higher-level features because they are more behaviorally relevant, and more invariant and categorical, and thus easier to specify and maintain in noisy working memory, and that more reliable higher-level decoding constrains less reliable lower-level decoding. PMID:29073108

  3. High-level spacecraft charging in the low-altitude polar auroral environment

    NASA Astrophysics Data System (ADS)

    Gussenhoven, M. S.; Hardy, D. A.; Rich, F.; Burke, W. J.; Yeh, H.-C.

    1985-11-01

    Regions of intense keV electron precipitation, such as inverted-V structures, at times colocate with ionospheric plasma depletion regions in the high-latitude polar ionosphere. When Defense Meteorological Satellite Program (DMSP) F6 and F7 satellites, at 840 km, enter these regions in darkness, ion signatures of high spacecraft-to-ambient plasma potential differences (several hundred volts negative) are observed with the new SSJ/4 ion detectors. A systematic survey of charging events and the environment in which they occur was made using the DMSP F6 and F7 precipitating ion and electron detectors, the SSIE thermal plasma probes, and the SSM (F7 only) vector magnetometer. The charging events of November 26, 1983, are analyzed in detail since they occurred on both satellites. Critical levels of number flux and average energy for the precipitating electrons, and the threshold density of the thermal ionospheric ions are defined for different levels of spacecraft charging.

  4. Oasis: A high-level/high-performance open source Navier-Stokes solver

    NASA Astrophysics Data System (ADS)

    Mortensen, Mikael; Valen-Sendstad, Kristian

    2015-03-01

    Oasis is a high-level/high-performance finite element Navier-Stokes solver written from scratch in Python using building blocks from the FEniCS project (fenicsproject.org). The solver is unstructured and targets large-scale applications in complex geometries on massively parallel clusters. Oasis utilizes MPI and interfaces, through FEniCS, to the linear algebra backend PETSc. Oasis advocates a high-level, programmable user interface through the creation of highly flexible Python modules for new problems. Through the high-level Python interface the user is placed in complete control of every aspect of the solver. A version of the solver, that is using piecewise linear elements for both velocity and pressure, is shown to reproduce very well the classical, spectral, turbulent channel simulations of Moser et al. (1999). The computational speed is strongly dominated by the iterative solvers provided by the linear algebra backend, which is arguably the best performance any similar implicit solver using PETSc may hope for. Higher order accuracy is also demonstrated and new solvers may be easily added within the same framework.

  5. OBSERVATIONS OF THE HIGH-MASS X-RAY BINARY A 0535+26 IN QUIESCENCE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rothschild, Richard; Markowitz, Alex; Hemphill, Paul

    2013-06-10

    We have analyzed three observations of the high-mass X-ray binary A 0535+26 performed by the Rossi X-Ray Timing Explorer (RXTE) three, five, and six months after the last outburst in 2011 February. We detect pulsations only in the second observation. The 3-20 keV spectra can be fit equally well with either an absorbed power law or absorbed thermal bremsstrahlung model. Reanalysis of two earlier RXTE observations made 4 yr after the 1994 outburst, original BeppoSAX observations 2 yr later, reanalysis of four EXOSAT observations made 2 yr after the last 1984 outburst, and a recent XMM-Newton observation in 2012 revealmore » a stacked, quiescent flux level decreasing from {approx}2 to <1 Multiplication-Sign 10{sup -11} erg cm{sup -2} s{sup -1} over 6.5 yr after outburst. The detection of pulsations during half of the quiescent observations would imply that accretion onto the magnetic poles of the neutron star continues despite the fact that the circumstellar disk may no longer be present. The accretion could come from material built up at the corotation radius or from an isotropic stellar wind.« less

  6. Observation of Phase-Filling Singularities in the Optical Dielectric Function of Highly Doped n-Type Ge.

    PubMed

    Xu, Chi; Fernando, Nalin S; Zollner, Stefan; Kouvetakis, John; Menéndez, José

    2017-06-30

    Phase-filling singularities in the optical response function of highly doped (>10^{19}  cm^{-3}) germanium are theoretically predicted and experimentally confirmed using spectroscopic ellipsometry. Contrary to direct-gap semiconductors, which display the well-known Burstein-Moss phenomenology upon doping, the critical point in the joint density of electronic states associated with the partially filled conduction band in n-Ge corresponds to the so-called E_{1} and E_{1}+Δ_{1} transitions, which are two-dimensional in character. As a result of this reduced dimensionality, there is no edge shift induced by Pauli blocking. Instead, one observes the "original" critical point (shifted only by band gap renormalization) and an additional feature associated with the level occupation discontinuity at the Fermi level. The experimental observation of this feature is made possible by the recent development of low-temperature, in situ doping techniques that allow the fabrication of highly doped films with exceptionally flat doping profiles.

  7. SPM observation of slow highly charged ion induced nanodots on highly orientated pyrolytic graphite

    NASA Astrophysics Data System (ADS)

    Mitsuda, Y.; Nakamura, B. E. O'Rourke1 N.; Kanai, Y.; Ohtani, S.; Yamazaki, Y.

    2007-03-01

    We have observed nanodots on a highly orientated pyrolytic graphite (HOPG) surface produced by highly charged ion impacts using a scanning tunneling microscope. Previous measurements have con.rmed the dominant role of the potential energy or the incident ion charge state on the size and height of the observed nanodots. The present results extend these previous measurements to much lower kinetic energy. It appears that there is no observable influence on the lateral size of the nanodots due to the incident ion kinetic energy down to approximately 200 eV. In contrast some slight reduction in the nanodot height was observed as the kinetic energy was reduced.

  8. Observation of Galactic Sources of Very High Energy γ-RAYS with the Magic Telescope

    NASA Astrophysics Data System (ADS)

    Bartko, H.

    The MAGIC telescope with its 17m diameter mirror is today the largest operating single-dish Imaging Air Cherenkov Telescope (IACT). It is located on the Canary Island La Palma, at an altitude of 2200 m above sea level, as part of the Roque de los Muchachos European Northern Observatory. The MAGIC telescope detects celestial very high energy γ-radiation in the energy band between about 50 GeV and 10 TeV. Since the autumn of 2004 MAGIC has been taking data routinely, observing various objects, like supernova remnants (SNRs), γ-ray binaries, Pulsars, Active Galactic Nuclei (AGN) and Gamma-ray Bursts (GRB). We briefly describe the observational strategy, the procedure implemented for the data analysis, and discuss the results of observations of Galactic Sources.

  9. Spaceborne Radar Observations of High Mountain Asia Snow and Ice

    NASA Astrophysics Data System (ADS)

    Lund, J.

    2016-12-01

    The glaciers of High Mountain Asia show a negative trend in mass balance. Within its sub regions, however, a complex pattern of climate regions and glacial forcings arise. This complexity, coupled with the challenges of field study in the region, illicit notable uncertainties both in observation and prediction of glacial mass balance. Beyond being valuable indicators of climate variability, the glaciers of High Mountain Asia are important water resources for densely populated downstream regions, and also contribute to global sea level rise. Scatterometry, regularly used in polar regions to detect melt in snow and ice, has seen little use in lower latitude glaciers. In High Mountain Asia, focus has been placed on spatial and temporal trends in scatterometer signals for melt onset and freeze-up. In polar regions, scatterometry and synthetic aperture radar (SAR) data have been used to estimate snow accumulation, along with interferometric SAR (InSAR) to measure glacier velocity, better constraining glacial mass balance estimates. For this poster, multiple radar sensors will be compared with both in situ as well as reanalysis precipitation data in varying climate regions in High Mountain Asia to explore correlations between snow accumulation and radar signals. Snowmelt timing influences on InSAR coherence may also be explored.

  10. Using Generalizability Theory to Examine Sources of Variance in Observed Behaviors within High School Classrooms

    ERIC Educational Resources Information Center

    Abry, Tashia; Cash, Anne H.; Bradshaw, Catherine P.

    2014-01-01

    Generalizability theory (GT) offers a useful framework for estimating the reliability of a measure while accounting for multiple sources of error variance. The purpose of this study was to use GT to examine multiple sources of variance in and the reliability of school-level teacher and high school student behaviors as observed using the tool,…

  11. TETRA observation of gamma-rays at ground level associated with nearby thunderstorms

    PubMed Central

    Ringuette, Rebecca; Case, Gary L; Cherry, Michael L; Granger, Douglas; Guzik, T Gregory; Stewart, Michael; Wefel, John P

    2013-01-01

    [1] Terrestrial gamma-ray flashes (TGFs)—very short, intense bursts of electrons, positrons, and energetic photons originating from terrestrial thunderstorms—have been detected with satellite instruments. TGF and Energetic Thunderstorm Rooftop Array (TETRA), an array of NaI(Tl) scintillators at Louisiana State University, has now been used to detect similar bursts of 50 keV to over 2 MeV gamma-rays at ground level. After 2.6 years of observation, 24 events with durations 0.02–4.2 ms have been detected associated with nearby lightning, three of them coincident events observed by detectors separated by ∼1000 m. Nine of the events occurred within 6 ms and 5 km of negative polarity cloud-to-ground lightning strokes with measured currents in excess of 20 kA. The events reported here constitute the first catalog of TGFs observed at ground level in close proximity to the acceleration site. PMID:26167428

  12. Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies.

    PubMed

    Li, Xue; Meng, Xiangrui; Timofeeva, Maria; Tzoulaki, Ioanna; Tsilidis, Konstantinos K; Ioannidis, John PA; Campbell, Harry; Theodoratou, Evropi

    2017-06-07

    Objective  To map the diverse health outcomes associated with serum uric acid (SUA) levels. Design  Umbrella review. Data sources  Medline, Embase, Cochrane Database of Systematic Reviews, and screening of citations and references. Eligibility criteria  Systematic reviews and meta-analyses of observational studies that examined associations between SUA level and health outcomes, meta-analyses of randomised controlled trials that investigated health outcomes related to SUA lowering treatment, and Mendelian randomisation studies that explored the causal associations of SUA level with health outcomes. Results  57 articles reporting 15 systematic reviews and144 meta-analyses of observational studies (76 unique outcomes), 8 articles reporting 31 meta-analyses of randomised controlled trials (20 unique outcomes), and 36 articles reporting 107 Mendelian randomisation studies (56 unique outcomes) met the eligibility criteria. Across all three study types, 136 unique health outcomes were reported. 16 unique outcomes in meta-analyses of observational studies had P<10 -6 , 8 unique outcomes in meta-analyses of randomised controlled trials had P<0.001, and 4 unique outcomes in Mendelian randomisation studies had P<0.01. Large between study heterogeneity was common (80% and 45% in meta-analyses of observational studies and of randomised controlled trials, respectively). 42 (55%) meta-analyses of observational studies and 7 (35%) meta-analyses of randomised controlled trials showed evidence of small study effects or excess significance bias. No associations from meta-analyses of observational studies were classified as convincing; five associations were classified as highly suggestive (increased risk of heart failure, hypertension, impaired fasting glucose or diabetes, chronic kidney disease, coronary heart disease mortality with high SUA levels). Only one outcome from randomised controlled trials (decreased risk of nephrolithiasis recurrence with SUA lowering treatment

  13. High-level fluorescence labeling of gram-positive pathogens.

    PubMed

    Aymanns, Simone; Mauerer, Stefanie; van Zandbergen, Ger; Wolz, Christiane; Spellerberg, Barbara

    2011-01-01

    Fluorescence labeling of bacterial pathogens has a broad range of interesting applications including the observation of living bacteria within host cells. We constructed a novel vector based on the E. coli streptococcal shuttle plasmid pAT28 that can propagate in numerous bacterial species from different genera. The plasmid harbors a promoterless copy of the green fluorescent variant gene egfp under the control of the CAMP-factor gene (cfb) promoter of Streptococcus agalactiae and was designated pBSU101. Upon transfer of the plasmid into streptococci, the bacteria show a distinct and easily detectable fluorescence using a standard fluorescence microscope and quantification by FACS-analysis demonstrated values that were 10-50 times increased over the respective controls. To assess the suitability of the construct for high efficiency fluorescence labeling in different gram-positive pathogens, numerous species were transformed. We successfully labeled Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus dysgalactiae subsp. equisimilis, Enterococcus faecalis, Enterococcus faecium, Streptococcus mutans, Streptococcus anginosus and Staphylococcus aureus strains utilizing the EGFP reporter plasmid pBSU101. In all of these species the presence of the cfb promoter construct resulted in high-level EGFP expression that could be further increased by growing the streptococcal and enterococcal cultures under high oxygen conditions through continuous aeration.

  14. High-Level Fluorescence Labeling of Gram-Positive Pathogens

    PubMed Central

    Aymanns, Simone; Mauerer, Stefanie; van Zandbergen, Ger; Wolz, Christiane; Spellerberg, Barbara

    2011-01-01

    Fluorescence labeling of bacterial pathogens has a broad range of interesting applications including the observation of living bacteria within host cells. We constructed a novel vector based on the E. coli streptococcal shuttle plasmid pAT28 that can propagate in numerous bacterial species from different genera. The plasmid harbors a promoterless copy of the green fluorescent variant gene egfp under the control of the CAMP-factor gene (cfb) promoter of Streptococcus agalactiae and was designated pBSU101. Upon transfer of the plasmid into streptococci, the bacteria show a distinct and easily detectable fluorescence using a standard fluorescence microscope and quantification by FACS-analysis demonstrated values that were 10–50 times increased over the respective controls. To assess the suitability of the construct for high efficiency fluorescence labeling in different gram-positive pathogens, numerous species were transformed. We successfully labeled Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus dysgalactiae subsp. equisimilis, Enterococcus faecalis, Enterococcus faecium, Streptococcus mutans, Streptococcus anginosus and Staphylococcus aureus strains utilizing the EGFP reporter plasmid pBSU101. In all of these species the presence of the cfb promoter construct resulted in high-level EGFP expression that could be further increased by growing the streptococcal and enterococcal cultures under high oxygen conditions through continuous aeration. PMID:21731607

  15. Regional sea level variability in a high-resolution global coupled climate model

    NASA Astrophysics Data System (ADS)

    Palko, D.; Kirtman, B. P.

    2016-12-01

    The prediction of trends at regional scales is essential in order to adapt to and prepare for the effects of climate change. However, GCMs are unable to make reliable predictions at regional scales. The prediction of local sea level trends is particularly critical. The main goal of this research is to utilize high-resolution (HR) (0.1° resolution in the ocean) coupled model runs of CCSM4 to analyze regional sea surface height (SSH) trends. Unlike typical, lower resolution (1.0°) GCM runs these HR runs resolve features in the ocean, like the Gulf Stream, which may have a large effect on regional sea level. We characterize the variability of regional SSH along the Atlantic coast of the US using tide gauge observations along with fixed radiative forcing runs of CCSM4 and HR interactive ensemble runs. The interactive ensemble couples an ensemble mean atmosphere with a single ocean realization. This coupling results in a 30% decrease in the strength of the Atlantic meridional overturning circulation; therefore, the HR interactive ensemble is analogous to a HR hosing experiment. By characterizing the variability in these high-resolution GCM runs and observations we seek to understand what processes influence coastal SSH along the Eastern Coast of the United States and better predict future SLR.

  16. Consistent estimate of ocean warming, land ice melt and sea level rise from Observations

    NASA Astrophysics Data System (ADS)

    Blazquez, Alejandro; Meyssignac, Benoît; Lemoine, Jean Michel

    2016-04-01

    Based on the sea level budget closure approach, this study investigates the consistency of observed Global Mean Sea Level (GMSL) estimates from satellite altimetry, observed Ocean Thermal Expansion (OTE) estimates from in-situ hydrographic data (based on Argo for depth above 2000m and oceanic cruises below) and GRACE observations of land water storage and land ice melt for the period January 2004 to December 2014. The consistency between these datasets is a key issue if we want to constrain missing contributions to sea level rise such as the deep ocean contribution. Numerous previous studies have addressed this question by summing up the different contributions to sea level rise and comparing it to satellite altimetry observations (see for example Llovel et al. 2015, Dieng et al. 2015). Here we propose a novel approach which consists in correcting GRACE solutions over the ocean (essentially corrections of stripes and leakage from ice caps) with mass observations deduced from the difference between satellite altimetry GMSL and in-situ hydrographic data OTE estimates. We check that the resulting GRACE corrected solutions are consistent with original GRACE estimates of the geoid spherical harmonic coefficients within error bars and we compare the resulting GRACE estimates of land water storage and land ice melt with independent results from the literature. This method provides a new mass redistribution from GRACE consistent with observations from Altimetry and OTE. We test the sensibility of this method to the deep ocean contribution and the GIA models and propose best estimates.

  17. 40 CFR 1065.725 - High-level ethanol-gasoline blends.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false High-level ethanol-gasoline blends... Calibration Standards § 1065.725 High-level ethanol-gasoline blends. For testing vehicles capable of operating on a high-level ethanol-gasoline blend, create a test fuel as follows: (a) Add ethanol to an E10 fuel...

  18. Interpretation of deep levels in Si-GaAs crystals observed by photo-induced current transient spectroscopy

    NASA Astrophysics Data System (ADS)

    Hlinomaz, P.; Šmíd, V.; Krištofik, J.

    1993-05-01

    Deep levels measured by Photo-Induced Current Transient Spectroscopy (PICTS) are interpreted taking into account different bulk and surface properties of semi-insulating crystals, results of directly measured isothermal transients and types of observed deep levels determined from the measurements with different voltage polarity. The principal interest is focused on the temperature interval 250-450 K where peaks related to the deep levels causing semiinsulating properties are observed in the PICTS spectra. Majority of deep levels observed in various samples may be ascribed to the EL2, EL3, EL4, HL1 and HL9 levels. Maxima exhibiting inverse polarity in PICTS spectra are not related to EL2 or HL1.

  19. Quenching from highly-excited SiO rotational levels due to H2 collision

    NASA Astrophysics Data System (ADS)

    Stancil, Phillip C.; Belayneh, Michael; Wan, Yier; Yang, Benhui H.

    2018-06-01

    Using a full quantum-mechanical close-coupling approach on a 4D rigid-rotor potential energy surface (PES), we performed scattering calculations for highly-excited rotational levels (j=6-10) of SiO for interactions with H2 for the first time. Emission lines from highly excited SiO rotational levels are observed in a variety of environments including outflows from AGB stars. However, explicit collisional data are lacking for H2 colliders, except for recent work from our group for j=1-5. Here we extend that work using a hybrid OpenMP/MPI scattering code and a PES computed at the CCSD(T)-F12b level of theory. The H2 and SiO bond lengths are fixed at their equilibrium values. The current results will allow for non-local thermodynamic models of SiO rotational emission from AGB stars. This work was funded by NASA grant NNX16AF09G.

  20. High reliability level on single-mode 980nm-1060 nm diode lasers for telecommunication and industrial applications

    NASA Astrophysics Data System (ADS)

    Van de Casteele, J.; Bettiati, M.; Laruelle, F.; Cargemel, V.; Pagnod-Rossiaux, P.; Garabedian, P.; Raymond, L.; Laffitte, D.; Fromy, S.; Chambonnet, D.; Hirtz, J. P.

    2008-02-01

    We demonstrate very high reliability level on 980-1060nm high-power single-mode lasers through multi-cell tests. First, we show how our chip design and technology enables high reliability levels. Then, we aged 758 devices during 9500 hours among 6 cells with high current (0.8A-1.2A) and high submount temperature (65°C-105°C) for the reliability demonstration. Sudden catastrophic failure is the main degradation mechanism observed. A statistical failure rate model gives an Arrhenius thermal activation energy of 0.51eV and a power law forward current acceleration factor of 5.9. For high-power submarine applications (360mW pump module output optical power), this model exhibits a failure rate as low as 9 FIT at 13°C, while ultra-high power terrestrial modules (600mW) lie below 220 FIT at 25°C. Wear-out phenomena is observed only for very high current level without any reliability impact under 1.1A. For the 1060nm chip, step-stress tests were performed and a set of devices were aged during more than 2000 hours in different stress conditions. First results are in accordance with 980nm product with more than 100khours estimated MTTF. These reliability and performance features of 980-1060nm laser diodes will make high-power single-mode emitters the best choice for a number of telecommunication and industrial applications in the next few years.

  1. High-intensity interval training evokes larger serum BDNF levels compared with intense continuous exercise.

    PubMed

    Saucedo Marquez, Cinthia Maria; Vanaudenaerde, Bart; Troosters, Thierry; Wenderoth, Nicole

    2015-12-15

    Exercise can have a positive effect on the brain by activating brain-derived neurotrophic factor (BDNF)-related processes. In healthy humans there appears to be a linear relationship between exercise intensity and the positive short-term effect of acute exercise on BDNF levels (i.e., the highest BDNF levels are reported after high-intensity exercise protocols). Here we performed two experiments to test the effectiveness of two high-intensity exercise protocols, both known to improve cardiovascular health, to determine whether they have a similar efficacy in affecting BDNF levels. Participants performed a continuous exercise (CON) protocol at 70% of maximal work rate and a high-intensity interval-training (HIT) protocol at 90% of maximal work rate for periods of 1 min alternating with 1 min of rest (both protocols lasted 20 min). We observed similar BDNF kinetics in both protocols, with maximal BDNF concentrations being reached toward the end of training (experiment 1). We then showed that both exercise protocols significantly increase BDNF levels compared with a rest condition (CON P = 0.04; HIT P < 0.001), with HIT reaching higher BDNF levels than CON (P = 0.035) (experiment 2). These results suggest that shorter bouts of high intensity exercise are slightly more effective than continuous high-intensity exercise for elevating serum BDNF. Additionally, 73% of the participants preferred the HIT protocol (P = 0.02). Therefore, we suggest that the HIT protocol might represent an effective and preferred intervention for elevating BDNF levels and potentially promoting brain health. Copyright © 2015 the American Physiological Society.

  2. Effect of high fluoride and high fat on serum lipid levels and oxidative stress in rabbits.

    PubMed

    Sun, Liyan; Gao, Yanhui; Zhang, Wei; Liu, Hui; Sun, Dianjun

    2014-11-01

    The purpose of this study was to explore the effects of high fluoride and high fat on triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), total antioxidant capacity (T-AOC), lipid peroxide (LPO) and malondialdehyde (MDA) in rabbits. A factorial experimental design was used, with two factors (fluoride and fat) and three levels. Seventy-two male rabbits were randomly assigned into nine groups according to initial weight and serum lipid levels. The rabbits were fed with basic feed, moderate fat feed or high fat feed and drank tap water, fluoridated water at levels of 50 and 100mgfluorion/L freely. Biological materials were collected after 5 months, and serum lipid, T-AOC, LPO, and MDA levels were then measured. Using these data, the separate and interactive effects of high fluoride and high fat were analyzed. High fluoride and high fat both increased serum levels of TC, HDL-C and LDL-C significantly (P<0.05), and there was also a synergistic effect between high fluoride and high fat (P<0.05). High fluoride and high fat had different effects on TG levels: high fat significantly increased TG levels (P<0.01) whereas high fluoride had nothing to do with TG levels (P>0.05). High fat significantly elevated LPO and MDA levels and lowered T-AOC levels in serum (P<0.05). Similarly, high fluoride significantly increased LPO and MDA levels in serum (P<0.05). However, there was no interactive effect between high fat and high fluoride on these indexes. In summary, high fluoride and high fat increased serum TC and LDL-C levels individually and synergistically, and this would cause and aggravate hypercholesterolemia in rabbits. At the same time, high fluoride and high fat both made the accumulation of product of oxidative stress in experimental animals. Copyright © 2014 Elsevier B.V. All rights reserved.

  3. The HST Frontier Fields: Complete High-Level Science Data Products for All 6 Clusters

    NASA Astrophysics Data System (ADS)

    Koekemoer, Anton M.; Mack, Jennifer; Lotz, Jennifer M.; Borncamp, David; Khandrika, Harish G.; Lucas, Ray A.; Martlin, Catherine; Porterfield, Blair; Sunnquist, Ben; Anderson, Jay; Avila, Roberto J.; Barker, Elizabeth A.; Grogin, Norman A.; Gunning, Heather C.; Hilbert, Bryan; Ogaz, Sara; Robberto, Massimo; Sembach, Kenneth; Flanagan, Kathryn; Mountain, Matt; HST Frontier Fields Team

    2017-01-01

    The Hubble Space Telescope Frontier Fields program (PI: J. Lotz) is a large Director's Discretionary program of 840 orbits, to obtain ultra-deep observations of six strong lensing clusters of galaxies, together with parallel deep blank fields, making use of the strong lensing amplification by these clusters of distant background galaxies to detect the faintest galaxies currently observable in the high-redshift universe. The entire program has now completed successfully for all 6 clusters, namely Abell 2744, Abell S1063, Abell 370, MACS J0416.1-2403, MACS J0717.5+3745 and MACS J1149.5+2223,. Each of these was observed over two epochs, to a total depth of 140 orbits on the main cluster and an associated parallel field, obtaining images in ACS (F435W, F606W, F814W) and WFC3/IR (F105W, F125W, F140W, F160W) on both the main cluster and the parallel field in all cases. Full sets of high-level science products have been generated for all these clusters by the team at STScI, including cumulative-depth data releases during each epoch, as well as full-depth releases after the completion of each epoch. These products include all the full-depth distortion-corrected drizzled mosaics and associated products for each cluster, which are science-ready to facilitate the construction of lensing models as well as enabling a wide range of other science projects. Many improvements beyond default calibration for ACS and WFC3/IR are implemented in these data products, including corrections for persistence, time-variable sky, and low-level dark current residuals, as well as improvements in astrometric alignment to achieve milliarcsecond-level accuracy. The full set of resulting high-level science products and mosaics are publicly delivered to the community via the Mikulski Archive for Space Telescopes (MAST) to enable the widest scientific use of these data, as well as ensuring a public legacy dataset of the highest possible quality that is of lasting value to the entire community.

  4. Monitoring Lake and Reservoir Level: Satellite Observations, Modeling and Prediction

    NASA Astrophysics Data System (ADS)

    Ricko, M.; Birkett, C. M.; Adler, R. F.; Carton, J.

    2013-12-01

    Satellite measurements of lake and reservoir water levels complement in situ observations by providing stage information for un-gauged basins and by filling data gaps in gauge records. However, different satellite radar altimeter-derived continental water level products may differ significantly owing to choice of satellites and data processing methods. To explore the impacts of these differences, a direct comparison between three different altimeter-based surface water level estimates (USDA/NASA GRLM, LEGOS and ESA-DMU) will be presented and products validated with lake level gauge time series for lakes and reservoirs of a variety of sizes and conditions. The availability of satellite-based rainfall (i.e., TRMM and GPCP) and satellite-based lake/reservoir levels offers exciting opportunities to estimate and monitor the hydrologic properties of the lake systems. Here, a simple water balance model is utilized to relate net freshwater flux on a catchment basin to lake/reservoir level. Focused on tropical lakes and reservoirs it allows a comparison of the flux to altimetric lake level estimates. The combined use of model, satellite-based rainfall, evaporation information and reanalysis products, can be used to output water-level hindcasts and seasonal future forecasts. Such a tool is fundamental for understanding present-day and future variations in lake/reservoir levels and enabling a better understand of climatic variations on inter-annual to inter-decadal time-scales. New model-derived water level estimates of lakes and reservoirs, on regional to global scales, would assist communities with interests in climate studies focusing on extreme events, such as floods and droughts, and be important for water resources management.

  5. Vertical Gravimeter Array Observations and Their Performance in Groundwater-Level Monitoring

    NASA Astrophysics Data System (ADS)

    Tanaka, T.; Honda, R.

    2018-03-01

    The gravitational effects of the atmosphere and subsurface water are significant obstacles to observing gravity variations on the sub-μGal (1 μGal = 10 nm/s2) scale. The goal of this study is to detect changes in gravity that are caused by mass redistributions deep underground related to seismological phenomena by reducing environmental gravity effects using multiple gravimeters belowground and aboveground, which we term a "vertical gravimeter array." Based on an evaluation of the responses to atmospheric effects and rainfall events identified in observations made with individual relative gravimeters, the vertical gravimeter array succeeds in stacking the target signals from deep underground and in reducing errors due to rainfall or free groundwater and atmospheric effects. To enable accurate interpretation, we introduce a physical approach that is based on attraction and loading deformation effects for atmospheric reduction using state-of-the-art gridded weather data products. Changes in the water levels of confined groundwater can be regarded as a signal from deep underground, and a response coefficient of approximately -15 μGal/m was obtained. In addition, the response coefficient of the free groundwater level was determined to be approximately 5 μGal/m. Such array observations are expected to contribute to monitoring crustal activity and hydrological studies.

  6. Connecting Earth observation to high-throughput biodiversity data.

    PubMed

    Bush, Alex; Sollmann, Rahel; Wilting, Andreas; Bohmann, Kristine; Cole, Beth; Balzter, Heiko; Martius, Christopher; Zlinszky, András; Calvignac-Spencer, Sébastien; Cobbold, Christina A; Dawson, Terence P; Emerson, Brent C; Ferrier, Simon; Gilbert, M Thomas P; Herold, Martin; Jones, Laurence; Leendertz, Fabian H; Matthews, Louise; Millington, James D A; Olson, John R; Ovaskainen, Otso; Raffaelli, Dave; Reeve, Richard; Rödel, Mark-Oliver; Rodgers, Torrey W; Snape, Stewart; Visseren-Hamakers, Ingrid; Vogler, Alfried P; White, Piran C L; Wooster, Martin J; Yu, Douglas W

    2017-06-22

    Understandably, given the fast pace of biodiversity loss, there is much interest in using Earth observation technology to track biodiversity, ecosystem functions and ecosystem services. However, because most biodiversity is invisible to Earth observation, indicators based on Earth observation could be misleading and reduce the effectiveness of nature conservation and even unintentionally decrease conservation effort. We describe an approach that combines automated recording devices, high-throughput DNA sequencing and modern ecological modelling to extract much more of the information available in Earth observation data. This approach is achievable now, offering efficient and near-real-time monitoring of management impacts on biodiversity and its functions and services.

  7. Observation of High-Harmonic Generation from an Atomically Thin Semiconductor [Observation of High Harmonics from and Atomically Thin Semiconductor

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu, Hanzhe; Li, Yilei; You, Yongsing

    We report the observation of nonperturbative high-harmonic generation from monolayer MoS 2. Here, the yield is higher in monolayer compared to a single layer of the bulk, an effect attributed to strong electron-hole interactions in the monolayer.

  8. Observation of High-Harmonic Generation from an Atomically Thin Semiconductor [Observation of High Harmonics from and Atomically Thin Semiconductor

    DOE PAGES

    Liu, Hanzhe; Li, Yilei; You, Yongsing; ...

    2016-01-01

    We report the observation of nonperturbative high-harmonic generation from monolayer MoS 2. Here, the yield is higher in monolayer compared to a single layer of the bulk, an effect attributed to strong electron-hole interactions in the monolayer.

  9. High-Level Waste System Process Interface Description

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    d'Entremont, P.D.

    1999-01-14

    The High-Level Waste System is a set of six different processes interconnected by pipelines. These processes function as one large treatment plant that receives, stores, and treats high-level wastes from various generators at SRS and converts them into forms suitable for final disposal. The three major forms are borosilicate glass, which will be eventually disposed of in a Federal Repository, Saltstone to be buried on site, and treated water effluent that is released to the environment.

  10. Effect of High Intensity Interval and Continuous Swimming Training on Body Mass Adiposity Level and Serum Parameters in High-Fat Diet Fed Rats

    PubMed Central

    da Rocha, Guilherme L.; Crisp, Alex H.; de Oliveira, Maria R. M.; da Silva, Carlos A.; Silva, Jadson O.; Duarte, Ana C. G. O.; Sene-Fiorese, Marcela; Verlengia, Rozangela

    2016-01-01

    This study aimed to investigate the effects of interval and continuous training on the body mass gain and adiposity levels of rats fed a high-fat diet. Forty-eight male Sprague-Dawley rats were randomly divided into two groups, standard diet and high-fat diet, and received their respective diets for a period of four weeks without exercise stimuli. After this period, the animals were randomly divided into six groups (n = 8): control standard diet (CS), control high-fat diet (CH), continuous training standard diet (CTS), continuous training high-fat diet (CTH), interval training standard diet (ITS), and interval training high-fat diet (ITH). The interval and continuous training consisted of a swimming exercise performed over eight weeks. CH rats had greater body mass gain, sum of adipose tissues mass, and lower serum high density lipoprotein values than CS. The trained groups showed lower values of feed intake, caloric intake, body mass gain, and adiposity levels compared with the CH group. No significant differences were observed between the trained groups (CTS versus ITS and CTH versus ITH) on body mass gains and adiposity levels. In conclusion, both training methodologies were shown to be effective in controlling body mass gain and adiposity levels in high-fat diet fed rats. PMID:26904718

  11. Effect of High Intensity Interval and Continuous Swimming Training on Body Mass Adiposity Level and Serum Parameters in High-Fat Diet Fed Rats.

    PubMed

    da Rocha, Guilherme L; Crisp, Alex H; de Oliveira, Maria R M; da Silva, Carlos A; Silva, Jadson O; Duarte, Ana C G O; Sene-Fiorese, Marcela; Verlengia, Rozangela

    2016-01-01

    This study aimed to investigate the effects of interval and continuous training on the body mass gain and adiposity levels of rats fed a high-fat diet. Forty-eight male Sprague-Dawley rats were randomly divided into two groups, standard diet and high-fat diet, and received their respective diets for a period of four weeks without exercise stimuli. After this period, the animals were randomly divided into six groups (n = 8): control standard diet (CS), control high-fat diet (CH), continuous training standard diet (CTS), continuous training high-fat diet (CTH), interval training standard diet (ITS), and interval training high-fat diet (ITH). The interval and continuous training consisted of a swimming exercise performed over eight weeks. CH rats had greater body mass gain, sum of adipose tissues mass, and lower serum high density lipoprotein values than CS. The trained groups showed lower values of feed intake, caloric intake, body mass gain, and adiposity levels compared with the CH group. No significant differences were observed between the trained groups (CTS versus ITS and CTH versus ITH) on body mass gains and adiposity levels. In conclusion, both training methodologies were shown to be effective in controlling body mass gain and adiposity levels in high-fat diet fed rats.

  12. Supporting observation campaigns with high resolution modeling

    NASA Astrophysics Data System (ADS)

    Klocke, Daniel; Brueck, Matthias; Voigt, Aiko

    2017-04-01

    High resolution simulation in support of measurement campaigns offers a promising and emerging way to create large-scale context for small-scale observations of clouds and precipitation processes. As these simulation include the coupling of measured small-scale processes with the circulation, they also help to integrate the research communities from modeling and observations and allow for detailed model evaluations against dedicated observations. In connection with the measurement campaign NARVAL (August 2016 and December 2013) simulations with a grid-spacing of 2.5 km for the tropical Atlantic region (9000x3300 km), with local refinement to 1.2 km for the western part of the domain, were performed using the icosahedral non-hydrostatic (ICON) general circulation model. These simulations are again used to drive large eddy resolving simulations with the same model for selected days in the high definition clouds and precipitation for advancing climate prediction (HD(CP)2) project. The simulations are presented with the focus on selected results showing the benefit for the scientific communities doing atmospheric measurements and numerical modeling of climate and weather. Additionally, an outlook will be given on how similar simulations will support the NAWDEX measurement campaign in the North Atlantic and AC3 measurement campaign in the Arctic.

  13. Time-resolved High Spectral Resolution Observation of 2MASSW J0746425+200032AB

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Ji; Mawet, Dimitri; Prato, Lisa, E-mail: ji.wang@caltech.edu

    Many brown dwarfs (BDs) exhibit photometric variability at levels from tenths to tens of percents. The photometric variability is related to magnetic activity or patchy cloud coverage, characteristic of BDs near the L–T transition. Time-resolved spectral monitoring of BDs provides diagnostics of cloud distribution and condensate properties. However, current time-resolved spectral studies of BDs are limited to low spectral resolution ( R ∼ 100) with the exception of the study of Luhman 16 AB at a resolution of 100,000 using the VLT+CRIRES. This work yielded the first map of BD surface inhomogeneity, highlighting the importance and unique contribution of highmore » spectral resolution observations. Here, we report on the time-resolved high spectral resolution observations of a nearby BD binary, 2MASSW J0746425+200032AB. We find no coherent spectral variability that is modulated with rotation. Based on simulations, we conclude that the coverage of a single spot on 2MASSW J0746425+200032AB is smaller than 1% or 6.25% if spot contrast is 50% or 80% of its surrounding flux, respectively. Future high spectral resolution observations aided by adaptive optics systems can put tighter constraints on the spectral variability of 2MASSW J0746425+200032AB and other nearby BDs.« less

  14. High levels of absorption in orientation-unbiased, radio-selected 3CR Active Galaxies

    NASA Astrophysics Data System (ADS)

    Wilkes, Belinda J.; Haas, Martin; Barthel, Peter; Leipski, Christian; Kuraszkiewicz, Joanna; Worrall, Diana; Birkinshaw, Mark; Willner, Steven P.

    2014-08-01

    A critical problem in understanding active galaxies (AGN) is the separation of intrinsic physical differences from observed differences that are due to orientation. Obscuration of the active nucleus is anisotropic and strongly frequency dependent leading to complex selection effects for observations in most wavebands. These can only be quantified using a sample that is sufficiently unbiased to test orientation effects. Low-frequency radio emission is one way to select a close-to orientation-unbiased sample, albeit limited to the minority of AGN with strong radio emission.Recent Chandra, Spitzer and Herschel observations combined with multi-wavelength data for a complete sample of high-redshift (1 24.2) = 2.5:1.4:1 in these high-luminosity (log L(0.3-8keV) ~ 44-46) sources. These ratios are consistent with current expectations based on modelingthe Cosmic X-ray Background. A strong correlation with radio orientation constrains the geometry of the obscuring disk/torus to have a ~60 degree opening angle and ~12 degree Compton-thick cross-section. The deduced ~50% obscured fraction of the population contrasts with typical estimates of ~20% obscured in optically- and X-ray-selected high-luminosity samples. Once the primary nuclear emission is obscured, AGN X-ray spectra are frequently dominated by unobscured non-nuclear or scattered nuclear emission which cannot be distinguished from direct nuclear emission with a lower obscuration level unless high quality data is available. As a result, both the level of obscuration and the estimated instrinsic luminosities of highly-obscured AGN are likely to be significantly (*10-1000) underestimated for 25-50% of the population. This may explain the lower obscured fractions reported for optical and X-ray samples which have no independent measure of the AGN

  15. The CMS High-Level Trigger

    NASA Astrophysics Data System (ADS)

    Covarelli, R.

    2009-12-01

    At the startup of the LHC, the CMS data acquisition is expected to be able to sustain an event readout rate of up to 100 kHz from the Level-1 trigger. These events will be read into a large processor farm which will run the "High-Level Trigger" (HLT) selection algorithms and will output a rate of about 150 Hz for permanent data storage. In this report HLT performances are shown for selections based on muons, electrons, photons, jets, missing transverse energy, τ leptons and b quarks: expected efficiencies, background rates and CPU time consumption are reported as well as relaxation criteria foreseen for a LHC startup instantaneous luminosity.

  16. Observation of high-order quantum resonances in the kicked rotor.

    PubMed

    Kanem, J F; Maneshi, S; Partlow, M; Spanner, M; Steinberg, A M

    2007-02-23

    Quantum resonances in the kicked rotor are characterized by a dramatically increased energy absorption rate, in stark contrast to the momentum localization generally observed. These resonances occur when the scaled Planck's constant Planck's [over ]=r/s 4pi, for any integers r and s. However, only the variant Planck's [over ]=r2pi resonances are easily observable. We have observed high-order quantum resonances (s>2) utilizing a sample of low energy, noncondensed atoms and a pulsed optical standing wave. Resonances are observed for variant Planck's [over ]=r/16 4pi for integers r=2-6. Quantum numerical simulations suggest that our observation of high-order resonances indicate a larger coherence length (i.e., coherence between different wells) than expected from an initially thermal atomic sample.

  17. High energy electrons beyond 100 GEV observed by emulsion chamber

    NASA Technical Reports Server (NTRS)

    Nishimura, J.; Fujii, M.; Yoshida, A.; Taira, T.; Aizu, H.; Nomura, Y.; Kobayashi, T.; Kazuno, M.; Nishio, A.; Golden, R. L.

    1986-01-01

    Much efforts have been expended to observe the spectrum of electrons in the high energy region with large area emulsion chambers exposed at balloon altitudes, and now 15 electrons beyond 1 TeV have been observed. The observed integral flux at 1 TeV is (3.24 + or - 0.87)x10(-5)/sq m sec sr. The statistics of the data around a few hundred GeV are also improving by using new shower detecting films of high sensitivity. The astrophysical significance of the observed spectrum are discussed for the propagation of electrons based on the leaky box and the nested leaky box model.

  18. Airport low-level wind shear lidar observation at beijing capital international airport

    NASA Astrophysics Data System (ADS)

    Zhang, Hongwei; Wu, Songhua; Wang, Qichao; Liu, Bingyi; Zhai, Xiaochun

    2018-04-01

    Ocean University of China lidar team operated a pulse coherent Doppler lidar (PCDL) for the low level wind shear monitoring at the Beijing Capital International Airport (BCIA) in 2015. The experiment configuration, observation modes is presented. A case study shows that the low level wind shear events at the southern end of 18R/36L runway were mainly caused by the trees and buildings along the glide path under strong northwest wind conditions.

  19. High resolution solar observations from first principles to applications

    NASA Astrophysics Data System (ADS)

    Verdoni, Angelo P.

    2009-10-01

    The expression "high-resolution observations" in Solar Physics refers to the spatial, temporal and spectral domains in their entirety. High-resolution observations of solar fine structure are a necessity to answer many of the intriguing questions related to solar activity. However, a researcher building instruments for high-resolution observations has to cope with the fact that these three domains often have diametrically opposed boundary conditions. Many factors have to be considered in the design of a successful instrument. Modern post-focus instruments are more closely linked with the solar telescopes that they serve than in past. In principle, the quest for high-resolution observations already starts with the selection of the observatory site. The site survey of the Advanced Technology Solar Telescope (ATST) under the stewardship of the National Solar Observatory (NSO) has identified Big Bear Solar Observatory (BBSO) as one of the best sites for solar observations. In a first step, the seeing characteristics at BBSO based on the data collected for the ATST site survey are described. The analysis will aid in the scheduling of high-resolution observations at BBSO as well as provide useful information concerning the design and implementation of a thermal control system for the New Solar Telescope (NST). NST is an off-axis open-structure Gregorian-style telescope with a 1.6 m aperture. NST will be housed in a newly constructed 5/8-sphere ventilated dome. With optics exposed to the surrounding air, NST's open-structure design makes it particularly vulnerable to the effects of enclosure-related seeing. In an effort to mitigate these effects, the initial design of a thermal control system for the NST dome is presented. The goal is to remediate thermal related seeing effects present within the dome interior. The THermal Control System (THCS) is an essential component for the open-telescope design of NST to work. Following these tasks, a calibration routine for the

  20. High resolution observations: The state of the art and beyond

    NASA Technical Reports Server (NTRS)

    Title, A.; Tarbell, T.; Shine, R.; Topka, K.; Frank, Z.

    1992-01-01

    The meaning of high resolution and its scientific importance with regard to solar observations is discussed. The state of the art is reviewed, looking into Solar Optical Universal Polarimeter (SOUP) observations, image selection techniques, and adaptive optics. It is concluded that until there are observations in space, complete understanding of processes in the solar photosphere, chromosphere, transition region, and corona will be impossible. The importance of high resolution is considered with regard to solar surface and convection, solar photosphere inside and outside magnetic fields, and sunspot geometry.

  1. Inundation of a barrier island (Chandeleur Islands, Louisiana, USA) during a hurricane: Observed water-level gradients and modeled seaward sand transport

    NASA Astrophysics Data System (ADS)

    Sherwood, Christopher R.; Long, Joseph W.; Dickhudt, Patrick J.; Dalyander, P. Soupy; Thompson, David M.; Plant, Nathaniel G.

    2014-07-01

    Large geomorphic changes to barrier islands may occur during inundation, when storm surge exceeds island elevation. Inundation occurs episodically and under energetic conditions that make quantitative observations difficult. We measured water levels on both sides of a barrier island in the northern Chandeleur Islands during inundation by Hurricane Isaac. Wind patterns caused the water levels to slope from the bay side to the ocean side for much of the storm. Modeled geomorphic changes during the storm were very sensitive to the cross-island slopes imposed by water-level boundary conditions. Simulations with equal or landward sloping water levels produced the characteristic barrier island storm response of overwash deposits or displaced berms with smoother final topography. Simulations using the observed seaward sloping water levels produced cross-barrier channels and deposits of sand on the ocean side, consistent with poststorm observations. This sensitivity indicates that accurate water-level boundary conditions must be applied on both sides of a barrier to correctly represent the geomorphic response to inundation events. More broadly, the consequence of seaward transport is that it alters the relationship between storm intensity and volume of landward transport. Sand transported to the ocean side may move downdrift, or aid poststorm recovery by moving onto the beach face or closing recent breaches, but it does not contribute to island transgression or appear as an overwash deposit in the back-barrier stratigraphic record. The high vulnerability of the Chandeleur Islands allowed us to observe processes that are infrequent but may be important at other barrier islands.

  2. Mapping of CO2 at High Spatiotemporal Resolution using Satellite Observations: Global distributions from OCO-2

    NASA Technical Reports Server (NTRS)

    Hammerling, Dorit M.; Michalak, Anna M.; Kawa, S. Randolph

    2012-01-01

    Satellite observations of CO2 offer new opportunities to improve our understanding of the global carbon cycle. Using such observations to infer global maps of atmospheric CO2 and their associated uncertainties can provide key information about the distribution and dynamic behavior of CO2, through comparison to atmospheric CO2 distributions predicted from biospheric, oceanic, or fossil fuel flux emissions estimates coupled with atmospheric transport models. Ideally, these maps should be at temporal resolutions that are short enough to represent and capture the synoptic dynamics of atmospheric CO2. This study presents a geostatistical method that accomplishes this goal. The method can extract information about the spatial covariance structure of the CO2 field from the available CO2 retrievals, yields full coverage (Level 3) maps at high spatial resolutions, and provides estimates of the uncertainties associated with these maps. The method does not require information about CO2 fluxes or atmospheric transport, such that the Level 3 maps are informed entirely by available retrievals. The approach is assessed by investigating its performance using synthetic OCO-2 data generated from the PCTM/ GEOS-4/CASA-GFED model, for time periods ranging from 1 to 16 days and a target spatial resolution of 1deg latitude x 1.25deg longitude. Results show that global CO2 fields from OCO-2 observations can be predicted well at surprisingly high temporal resolutions. Even one-day Level 3 maps reproduce the large-scale features of the atmospheric CO2 distribution, and yield realistic uncertainty bounds. Temporal resolutions of two to four days result in the best performance for a wide range of investigated scenarios, providing maps at an order of magnitude higher temporal resolution relative to the monthly or seasonal Level 3 maps typically reported in the literature.

  3. Performance of PHOTONIS' low light level CMOS imaging sensor for long range observation

    NASA Astrophysics Data System (ADS)

    Bourree, Loig E.

    2014-05-01

    Identification of potential threats in low-light conditions through imaging is commonly achieved through closed-circuit television (CCTV) and surveillance cameras by combining the extended near infrared (NIR) response (800-10000nm wavelengths) of the imaging sensor with NIR LED or laser illuminators. Consequently, camera systems typically used for purposes of long-range observation often require high-power lasers in order to generate sufficient photons on targets to acquire detailed images at night. While these systems may adequately identify targets at long-range, the NIR illumination needed to achieve such functionality can easily be detected and therefore may not be suitable for covert applications. In order to reduce dependency on supplemental illumination in low-light conditions, the frame rate of the imaging sensors may be reduced to increase the photon integration time and thus improve the signal to noise ratio of the image. However, this may hinder the camera's ability to image moving objects with high fidelity. In order to address these particular drawbacks, PHOTONIS has developed a CMOS imaging sensor (CIS) with a pixel architecture and geometry designed specifically to overcome these issues in low-light level imaging. By combining this CIS with field programmable gate array (FPGA)-based image processing electronics, PHOTONIS has achieved low-read noise imaging with enhanced signal-to-noise ratio at quarter moon illumination, all at standard video frame rates. The performance of this CIS is discussed herein and compared to other commercially available CMOS and CCD for long-range observation applications.

  4. Looking away from faces: influence of high-level visual processes on saccade programming.

    PubMed

    Morand, Stéphanie M; Grosbras, Marie-Hélène; Caldara, Roberto; Harvey, Monika

    2010-03-30

    Human faces capture attention more than other visual stimuli. Here we investigated whether such face-specific biases rely on automatic (involuntary) or voluntary orienting responses. To this end, we used an anti-saccade paradigm, which requires the ability to inhibit a reflexive automatic response and to generate a voluntary saccade in the opposite direction of the stimulus. To control for potential low-level confounds in the eye-movement data, we manipulated the high-level visual properties of the stimuli while normalizing their global low-level visual properties. Eye movements were recorded in 21 participants who performed either pro- or anti-saccades to a face, car, or noise pattern, randomly presented to the left or right of a fixation point. For each trial, a symbolic cue instructed the observer to generate either a pro-saccade or an anti-saccade. We report a significant increase in anti-saccade error rates for faces compared to cars and noise patterns, as well as faster pro-saccades to faces and cars in comparison to noise patterns. These results indicate that human faces induce stronger involuntary orienting responses than other visual objects, i.e., responses that are beyond the control of the observer. Importantly, this involuntary processing cannot be accounted for by global low-level visual factors.

  5. Observations and Models of Highly Intermittent Phytoplankton Distributions

    PubMed Central

    Mandal, Sandip; Locke, Christopher; Tanaka, Mamoru; Yamazaki, Hidekatsu

    2014-01-01

    The measurement of phytoplankton distributions in ocean ecosystems provides the basis for elucidating the influences of physical processes on plankton dynamics. Technological advances allow for measurement of phytoplankton data to greater resolution, displaying high spatial variability. In conventional mathematical models, the mean value of the measured variable is approximated to compare with the model output, which may misinterpret the reality of planktonic ecosystems, especially at the microscale level. To consider intermittency of variables, in this work, a new modelling approach to the planktonic ecosystem is applied, called the closure approach. Using this approach for a simple nutrient-phytoplankton model, we have shown how consideration of the fluctuating parts of model variables can affect system dynamics. Also, we have found a critical value of variance of overall fluctuating terms below which the conventional non-closure model and the mean value from the closure model exhibit the same result. This analysis gives an idea about the importance of the fluctuating parts of model variables and about when to use the closure approach. Comparisons of plot of mean versus standard deviation of phytoplankton at different depths, obtained using this new approach with real observations, give this approach good conformity. PMID:24787740

  6. Observed mean sea level changes around the North Sea coastline from 1800 to present

    NASA Astrophysics Data System (ADS)

    Wahl, T.; Haigh, I. D.; Woodworth, P. L.; Albrecht, F.; Dillingh, D.; Jensen, J.; Nicholls, R. J.; Weisse, R.; Wöppelmann, G.

    2013-09-01

    This paper assesses historic changes in mean sea level around the coastline of the North Sea, one of the most densely populated coasts in the world. Typically, such analyses have been conducted at a national level, and detailed geographically wider analyses have not been undertaken for about 20 years. We analyse long records (up to 200 years) from 30 tide gauge sites, which are reasonably uniformly distributed along the coastline, and: (1) calculate relative sea level trends; (2) examine the inter-annual and decadal variations; (3) estimate regional geocentric (sometimes also referred to as 'absolute') sea level rise throughout the 20th century; and (4) assess the evidence for regional acceleration of sea-level rise. Relative sea level changes are broadly consistent with known vertical land movement patterns. The inter-annual and decadal variability is partly coherent across the region, but with some differences between the Inner North Sea and the English Channel. Data sets from various sources are used to provide estimates of the geocentric sea level changes. The long-term geocentric mean sea level trend for the 1900 to 2011 period is estimated to be 1.5 ± 0.1 mm/yr for the entire North Sea region. The trend is slightly higher for the Inner North Sea (i.e. 1.6 ± 0.1 mm/yr), and smaller but not significantly different on the 95% confidence level for the English Channel (i.e. 1.2 ± 0.1 mm/yr). The uncertainties in the estimates of vertical land movement rates are still large, and the results from a broad range of approaches for determining these rates are not consistent. Periods of sea level rise acceleration are detected at different times throughout the last 200 years and are to some extent related to air pressure variations. The recent rates of sea level rise (i.e. over the last two to three decades) are high compared to the long-term average, but are comparable to those which have been observed at other times in the late 19th and 20th century.

  7. Dynamically balanced absolute sea level of the global ocean derived from near-surface velocity observations

    NASA Astrophysics Data System (ADS)

    Niiler, Pearn P.; Maximenko, Nikolai A.; McWilliams, James C.

    2003-11-01

    The 1992-2002 time-mean absolute sea level distribution of the global ocean is computed for the first time from observations of near-surface velocity. For this computation, we use the near-surface horizontal momentum balance. The velocity observed by drifters is used to compute the Coriolis force and the force due to acceleration of water parcels. The anomaly of horizontal pressure gradient is derived from satellite altimetry and corrects the temporal bias in drifter data distribution. NCEP reanalysis winds are used to compute the force due to Ekman currents. The mean sea level gradient force, which closes the momentum balance, is integrated for mean sea level. We find that our computation agrees, within uncertainties, with the sea level computed from the geostrophic, hydrostatic momentum balance using historical mean density, except in the Antarctic Circumpolar Current. A consistent horizontally and vertically dynamically balanced, near-surface, global pressure field has now been derived from observations.

  8. 21 CFR 880.6885 - Liquid chemical sterilants/high level disinfectants.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Liquid chemical sterilants/high level... and Personal Use Miscellaneous Devices § 880.6885 Liquid chemical sterilants/high level disinfectants. (a) Identification. A liquid chemical sterilant/high level disinfectant is a germicide that is...

  9. 21 CFR 880.6885 - Liquid chemical sterilants/high level disinfectants.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Liquid chemical sterilants/high level... and Personal Use Miscellaneous Devices § 880.6885 Liquid chemical sterilants/high level disinfectants. (a) Identification. A liquid chemical sterilant/high level disinfectant is a germicide that is...

  10. 21 CFR 880.6885 - Liquid chemical sterilants/high level disinfectants.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Liquid chemical sterilants/high level... and Personal Use Miscellaneous Devices § 880.6885 Liquid chemical sterilants/high level disinfectants. (a) Identification. A liquid chemical sterilant/high level disinfectant is a germicide that is...

  11. 21 CFR 880.6885 - Liquid chemical sterilants/high level disinfectants.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Liquid chemical sterilants/high level... and Personal Use Miscellaneous Devices § 880.6885 Liquid chemical sterilants/high level disinfectants. (a) Identification. A liquid chemical sterilant/high level disinfectant is a germicide that is...

  12. 21 CFR 880.6885 - Liquid chemical sterilants/high level disinfectants.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Liquid chemical sterilants/high level... and Personal Use Miscellaneous Devices § 880.6885 Liquid chemical sterilants/high level disinfectants. (a) Identification. A liquid chemical sterilant/high level disinfectant is a germicide that is...

  13. Two solar proton fluence models based on ground level enhancement observations

    NASA Astrophysics Data System (ADS)

    Raukunen, Osku; Vainio, Rami; Tylka, Allan J.; Dietrich, William F.; Jiggens, Piers; Heynderickx, Daniel; Dierckxsens, Mark; Crosby, Norma; Ganse, Urs; Siipola, Robert

    2018-01-01

    Solar energetic particles (SEPs) constitute an important component of the radiation environment in interplanetary space. Accurate modeling of SEP events is crucial for the mitigation of radiation hazards in spacecraft design. In this study we present two new statistical models of high energy solar proton fluences based on ground level enhancement (GLE) observations during solar cycles 19-24. As the basis of our modeling, we utilize a four parameter double power law function (known as the Band function) fits to integral GLE fluence spectra in rigidity. In the first model, the integral and differential fluences for protons with energies between 10 MeV and 1 GeV are calculated using the fits, and the distributions of the fluences at certain energies are modeled with an exponentially cut-off power law function. In the second model, we use a more advanced methodology: by investigating the distributions and relationships of the spectral fit parameters we find that they can be modeled as two independent and two dependent variables. Therefore, instead of modeling the fluences separately at different energies, we can model the shape of the fluence spectrum. We present examples of modeling results and show that the two methodologies agree well except for a short mission duration (1 year) at low confidence level. We also show that there is a reasonable agreement between our models and three well-known solar proton models (JPL, ESP and SEPEM), despite the differences in both the modeling methodologies and the data used to construct the models.

  14. Endotoxin levels correlate positively with a sedentary lifestyle and negatively with highly trained subjects.

    PubMed

    Lira, Fabio S; Rosa, Jose C; Pimentel, Gustavo D; Souza, Hélio A; Caperuto, Erico C; Carnevali, Luiz C; Seelaender, Marília; Damaso, Ana R; Oyama, Lila M; de Mello, Marco T; Santos, Ronaldo V

    2010-08-04

    A sedentary lifestyle increases the risk of developing cardiovascular disease, obesity, and diabetes. This phenomenon is supported by recent studies suggesting a chronic, low-grade inflammation status. Endotoxin derived from gut flora may be key to the development of inflammation by stimulating the secretion of inflammatory factors. This study aimed to examine plasma inflammatory markers and endotoxin levels in individuals with a sedentary lifestyle and/or in highly trained subjects at rest. Fourteen male subjects (sedentary lifestyle n = 7; highly trained subjects n = 7) were recruited. Blood samples were collected after an overnight fast (approximately 12 h). The plasmatic endotoxin, plasminogen activator inhibitor type-1 (PAI-1), monocyte chemotactic protein-1 (MCP1), ICAM/CD54, VCAM/CD106 and lipid profile levels were determined. Endotoxinemia was lower in the highly trained subject group relative to the sedentary subjects (p < 0.002). In addition, we observed a positive correlation between endotoxin and PAI-1 (r = 0.85, p < 0.0001), endotoxin and total cholesterol (r = 0.65; p < 0.01), endotoxin and LDL-c (r = 0.55; p < 0.049) and endotoxin and TG levels (r = 0.90; p < 0.0001). The plasma levels of MCP-1, ICAM/CD54 and VCAM/CD106 did not differ. These results indicate that a lifestyle associated with high-intensity and high-volume exercise induces favorable changes in chronic low-grade inflammation markers and may reduce the risk for diseases such as obesity, diabetes and cardiovascular diseases.

  15. DistributedFBA.jl: High-level, high-performance flux balance analysis in Julia

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Heirendt, Laurent; Thiele, Ines; Fleming, Ronan M. T.

    Flux balance analysis and its variants are widely used methods for predicting steady-state reaction rates in biochemical reaction networks. The exploration of high dimensional networks with such methods is currently hampered by software performance limitations. DistributedFBA.jl is a high-level, high-performance, open-source implementation of flux balance analysis in Julia. It is tailored to solve multiple flux balance analyses on a subset or all the reactions of large and huge-scale networks, on any number of threads or nodes. DistributedFBA.jl is a high-level, high-performance, open-source implementation of flux balance analysis in Julia. It is tailored to solve multiple flux balance analyses on amore » subset or all the reactions of large and huge-scale networks, on any number of threads or nodes.« less

  16. DistributedFBA.jl: High-level, high-performance flux balance analysis in Julia

    DOE PAGES

    Heirendt, Laurent; Thiele, Ines; Fleming, Ronan M. T.

    2017-01-16

    Flux balance analysis and its variants are widely used methods for predicting steady-state reaction rates in biochemical reaction networks. The exploration of high dimensional networks with such methods is currently hampered by software performance limitations. DistributedFBA.jl is a high-level, high-performance, open-source implementation of flux balance analysis in Julia. It is tailored to solve multiple flux balance analyses on a subset or all the reactions of large and huge-scale networks, on any number of threads or nodes. DistributedFBA.jl is a high-level, high-performance, open-source implementation of flux balance analysis in Julia. It is tailored to solve multiple flux balance analyses on amore » subset or all the reactions of large and huge-scale networks, on any number of threads or nodes.« less

  17. Neural network controller development and implementation for spark ignition engines with high EGR levels.

    PubMed

    Vance, Jonathan Blake; Singh, Atmika; Kaul, Brian C; Jagannathan, Sarangapani; Drallmeier, James A

    2007-07-01

    Past research has shown substantial reductions in the oxides of nitrogen (NOx) concentrations by using 10%-25% exhaust gas recirculation (EGR) in spark ignition (SI) engines (see Dudek and Sain, 1989). However, under high EGR levels, the engine exhibits strong cyclic dispersion in heat release which may lead to instability and unsatisfactory performance preventing commercial engines to operate with high EGR levels. A neural network (NN)-based output feedback controller is developed to reduce cyclic variation in the heat release under high levels of EGR even when the engine dynamics are unknown by using fuel as the control input. A separate control loop was designed for controlling EGR levels. The stability analysis of the closed-loop system is given and the boundedness of the control input is demonstrated by relaxing separation principle, persistency of excitation condition, certainty equivalence principle, and linear in the unknown parameter assumptions. Online training is used for the adaptive NN and no offline training phase is needed. This online learning feature and model-free approach is used to demonstrate the applicability of the controller on a different engine with minimal effort. Simulation results demonstrate that the cyclic dispersion is reduced significantly using the proposed controller when implemented on an engine model that has been validated experimentally. For a single cylinder research engine fitted with a modern four-valve head (Ricardo engine), experimental results at 15% EGR indicate that cyclic dispersion was reduced 33% by the controller, an improvement of fuel efficiency by 2%, and a 90% drop in NOx from stoichiometric operation without EGR was observed. Moreover, unburned hydrocarbons (uHC) drop by 6% due to NN control as compared to the uncontrolled scenario due to the drop in cyclic dispersion. Similar performance was observed with the controller on a different engine.

  18. Depressurization and two-phase flow of water containing high levels of dissolved nitrogen gas

    NASA Technical Reports Server (NTRS)

    Simoneau, R. J.

    1981-01-01

    Depressurization of water containing various concentrations of dissolved nitrogen gas was studied. In a nonflow depressurization experiment, water with very high nitrogen content was depressurized at rates from 0.09 to 0.50 MPa per second and a metastable behavior which was a strong function of the depressurization rate was observed. Flow experiments were performed in an axisymmetric, converging diverging nozzle, a two dimensional, converging nozzle with glass sidewalls, and a sharp edge orifice. The converging diverging nozzle exhibited choked flow behavior even at nitrogen concentration levels as low as 4 percent of the saturation level. The flow rates were independent of concentration level. Flow in the two dimensional, converging, visual nozzle appeared to have a sufficient pressure drop at the throat to cause nitrogen to come out of solution, but choking occurred further downstream. The orifice flow motion pictures showed considerable oscillation downstream of the orifice and parallel to the flow. Nitrogen bubbles appeared in the flow at back pressures as high as 3.28 MPa, and the level at which bubbles were no longer visible was a function of nitrogen concentration.

  19. High level tritiated water monitoring by Bremsstrahlung counting using a silicon drift detector

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Niemes, S.; Sturm, M.; Michling, R.

    2015-03-15

    The β-ray induced X-ray spectrometry (BIXS) is a promising technique to monitor the tritium concentration in a fuel cycle of a fusion reactor. For in-situ measurements of high level tritiated water by Bremsstrahlung counting, the characteristics of a low-noise silicon drift detector (SDD) have been examined at the Tritium Laboratory Karlsruhe (TLK). In static measurements with constant sample volume and tritium concentration, the Bremsstrahlung spectra of tritiated water samples in a concentration range of 0.02 to 15 MBq/ml have been obtained. The volume has been kept constant at 5 cm{sup 3}. The observed spectra are well above the noise threshold.more » In addition to X-rays induced by β-rays, the spectra feature X-ray fluorescence peaks of the surrounding materials. No indications of memory effects have been observed. A linear relation between the X-ray intensity and the tritium concentration was obtained and the lower detection limit of the setup has been determined to 1 MBq ml{sup -1}, assessed by the Curie criterion. In addition, the spectra obtained experimentally could be reproduced with high agreement by Monte-Carlo simulations using the GEANT4-tool-kit. It was found that the present detection system is applicable to non-invasive measurements of high-level tritiated water and the SDD is a convenient tool to detect the low energy Bremsstrahlung X-rays. (authors)« less

  20. High serum testosterone levels during postpartum period are associated with postpartum depression.

    PubMed

    Aswathi, A; Rajendiren, Soundravally; Nimesh, Archana; Philip, R Ravi; Kattimani, Shivanand; Jayalakshmi, D; Ananthanarayanan, P H; Dhiman, Pooja

    2015-10-01

    In view of the reported cases of mood disorders that occur in mothers following childbirth and believing that sex steroid hormones contribute to mood and behavioral changes, this study has been aimed to explore the role of sex steroid hormones as an etiological factor for postpartum depression (PPD). This study was conducted at JIPMER, Puducherry, India between January 2010 and 2011. 103 women were recruited in the study after childbirth, out of which 62 women who were believed to be suffering from PPD were categorized as cases and the remaining 41 with no mood changes as controls, using Edinburgh Postpartum Depression Scale (EPDS) (cases had EPDS score ≥10 at 24-28h, controls had score <10 at 24-48h postpartum). The hormones estimated in these two groups included estradiol, progesterone and testosterone, and their levels were compared between these two groups. A significantly high testosterone levels were observed in cases with PPD at 24-28h when compared to controls. Estradiol and progesterone levels did not show significant difference between cases and controls. ROC analysis done at 24-28h showed that testosterone levels beyond 42.71ng/mL predict the development of PPD with 79% sensitivity, 63% specificity, 68% positive predictive value, 74% negative predictive value with AUC being 0.708. This study shows that there is an association between persistent high serum testosterone level in women following childbirth and PPD. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. Sterilization, high-level disinfection, and environmental cleaning.

    PubMed

    Rutala, William A; Weber, David J

    2011-03-01

    Failure to perform proper disinfection and sterilization of medical devices may lead to introduction of pathogens, resulting in infection. New techniques have been developed for achieving high-level disinfection and adequate environmental cleanliness. This article examines new technologies for sterilization and high-level disinfection of critical and semicritical items, respectively, and because semicritical items carry the greatest risk of infection, the authors discuss reprocessing semicritical items such as endoscopes and automated endoscope reprocessors, endocavitary probes, prostate biopsy probes, tonometers, laryngoscopes, and infrared coagulation devices. In addition, current issues and practices associated with environmental cleaning are reviewed. Copyright © 2011. Published by Elsevier Inc.

  2. Observation of g/u-symmetry mixing in the high-n Rydberg states of HD

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sprecher, Daniel; Merkt, Frédéric, E-mail: frederic.merkt@phys.chem.ethz.ch

    2014-03-28

    The structure and dynamics of high-n Rydberg states belonging to series converging to the (v{sup +} = 0, N{sup +} = 0–2) levels of the X{sup +2}Σ{sub g}{sup +} electronic ground state of HD{sup +} were studied by high-resolution spectroscopy from the GK{sup 1}Σ{sub g}{sup +} (v= 1, N = 1) state under field-free conditions. Three effects of g/u-symmetry breaking were detected: (i) Single-photon transitions from the GK (v = 1, N = 1) state of gerade symmetry to the 30d2{sub 1} and 31g2{sub 2} Rydberg states of gerade symmetry were observed after careful compensation of the stray electric fields. (ii)more » The singlet 61p1{sub 2} Rydberg state of ungerade symmetry was found to autoionize to the N{sup +} = 0, ℓ = 2 ionization continuum of gerade symmetry with a lifetime of 77(10) ns. (iii) Shifts of up to 20 MHz induced by g/u-symmetry mixing were measured for members of the np1{sub 1} Rydberg series which lie close to nd2{sub 1} Rydberg states. These observations were analyzed in the framework of multichannel quantum-defect theory. From the observed level shifts, the off-diagonal eigenquantum-defect element μ{sub pd} of singlet-π symmetry was determined to be 0.0023(3) and the corresponding autoionization dynamics could be characterized. The ionization energy of the GK (v = 1, N = 1) state of HD was determined to be 12 710.544 23(10) cm{sup −1}.« less

  3. Very-high energy observations of the galactic center region by VERITAS in 2010-2012

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Archer, A.; Beilicke, M.; Buckley, J. H.

    2014-08-01

    The Galactic center is an interesting region for high-energy (0.1-100 GeV) and very-high-energy (E > 100 GeV) γ-ray observations. Potential sources of GeV/TeV γ-ray emission have been suggested, e.g., the accretion of matter onto the supermassive black hole, cosmic rays from a nearby supernova remnant (e.g., Sgr A East), particle acceleration in a plerion, or the annihilation of dark matter particles. The Galactic center has been detected by EGRET and by Fermi/LAT in the MeV/GeV energy band. At TeV energies, the Galactic center was detected with moderate significance by the CANGAROO and Whipple 10 m telescopes and with high significancemore » by H.E.S.S., MAGIC, and VERITAS. We present the results from three years of VERITAS observations conducted at large zenith angles resulting in a detection of the Galactic center on the level of 18 standard deviations at energies above ∼2.5 TeV. The energy spectrum is derived and is found to be compatible with hadronic, leptonic, and hybrid emission models discussed in the literature. Future, more detailed measurements of the high-energy cutoff and better constraints on the high-energy flux variability will help to refine and/or disentangle the individual models.« less

  4. The Importance of High Frequency Observations for the SKA

    NASA Astrophysics Data System (ADS)

    Welch, William J.

    2007-12-01

    The plan for the Square Kilometer Array (SKA) is one or more very large arrays operating in two or more contiguous frequency bands: roughly 15 - 90 MHz, 120 - 500 MHz, and 500 MHz - 25 GHz. The last band may be further divided into roughly 500 MHz - 1.5 GHz and 1.5 - 25 GHz. Construction costs may delay or forgo one or more of these bands. We argue that the entire high frequency band is of special importance for astronomy both in the local universe and at great distances and early times. One of the Key Science Projects, the Cradle of Life, requires high sensitivity and resolution at frequencies up to 20 GHz for the study of forming disks around new stars with disk opacities too great for millimeter wave observations. The larger issue of star formation, a poorly understood area, will also benefit from high sensitivity observations at short cm wavelengths. Magnetic field measurements through the Zeeman effect in the densest star forming gas are best done using tracers such as CCS at frequencies of 11 and 22 GHz. The wide frequency range of the SKA permits the observation of multiple rotational transitions of long chain molecules, providing accurate measures of both gas densities and temperatures. The wide field of view will permit large scale surveys of entire star forming clouds revealing, at high resolution, the formation of clusters of pre-protostellar stars and class 0-2 protostars in line radiation. The continuum cm wave radiation will reveal the growth of grains in disks. On the larger scale, observations of CO at high redshifts will trace the evolution of star formation and the formation of metals back to the Epic of Reionization.

  5. High level of CA 125 due to large endometrioma.

    PubMed

    Phupong, Vorapong; Chen, Orawan; Ultchaswadi, Pornthip

    2004-09-01

    CA 125 is a tumor-associated antigen. Its high levels are usually associated with ovarian malignancies, whereas smaller increases in the levels were associated with benign gynecologic conditions. The authors report a high level of CA 125 in a case of large ovarian endometrioma. A 45-year-old nulliparous Thai woman, presented with an increase of her abdominal girth for 7 months. Transabdominal ultrasonogram demonstrated a large ovarian cyst and multiple small leiomyoma uteri, and serum CA 125 level was 1,006 U/ml. The preoperative diagnosis was ovarian cancer with leiomyoma uteri. Exploratory laparotomy was performed. There were a large right ovarian endometrioma, small left ovarian endometrioma and multiple small leiomyoma. Total abdominal hysterectomy and bilateral salpingo-oophorectomy was performed and histopathology confirmed the diagnosis of endometrioma and leiomyoma. The serum CA 125 level declined to non-detectable at the 4th week. She was well at discharge and throughout her 4th week follow-up period Although a very high level of CA 125 is associated with a malignant process, it can also be found in benign conditions such as a large endometrioma. The case emphasizes the association of high levels of CA 125 with benign gynecologic conditions.

  6. Broadband Observations of High Redshift Blazars

    NASA Astrophysics Data System (ADS)

    Paliya, Vaidehi S.; Parker, M. L.; Fabian, A. C.; Stalin, C. S.

    2016-07-01

    We present a multi-wavelength study of four high redshift blazars, S5 0014+81 (z = 3.37), CGRaBS J0225+1846 (z = 2.69), BZQ J1430+4205 (z = 4.72), and 3FGL J1656.2-3303 (z = 2.40) using quasi-simultaneous data from the Swift, Nuclear Spectroscopic Telescope Array (NuSTAR) and the Fermi-Large Area Telescope (LAT) and also archival XMM-Newton observations. Other than 3FGL J1656.2-3303, none of the sources were known as γ-ray emitters, and our analysis of ˜7.5 yr of LAT data reveals the first time detection of statistically significant γ-ray emission from CGRaBS J0225+1846. We generate the broadband spectral energy distributions (SED) of all the objects, centering at the epoch of NuSTAR observations and reproduce them using a one-zone leptonic emission model. The optical-UV emission in all the objects can be explained by radiation from the accretion disk, whereas the X-ray to γ-ray windows of the SEDs are found to be dominated by inverse Compton scattering off the broad line region photons. All of them host black holes that are billions of solar masses. Comparing the accretion disk luminosity and the jet power of these sources with a large sample of blazars, we find them to occupy a high disk luminosity-jet power regime. We also investigate the X-ray spectral properties of the sources in detail with a major focus on studying the causes of soft X-ray deficit, a feature generally seen in high redshift radio-loud quasars. We summarize that this feature could be explained based on the intrinsic curvature in the jet emission rather than being due to the external effects predicted in earlier studies, such as host galaxy and/or warm absorption.

  7. BROADBAND OBSERVATIONS OF HIGH REDSHIFT BLAZARS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Paliya, Vaidehi S.; Parker, M. L.; Fabian, A. C.

    We present a multi-wavelength study of four high redshift blazars, S5 0014+81 ( z = 3.37), CGRaBS J0225+1846 ( z = 2.69), BZQ J1430+4205 ( z = 4.72), and 3FGL J1656.2−3303 ( z = 2.40) using quasi-simultaneous data from the Swift , Nuclear Spectroscopic Telescope Array ( NuSTAR ) and the Fermi -Large Area Telescope (LAT) and also archival XMM-Newton observations. Other than 3FGL J1656.2−3303, none of the sources were known as γ -ray emitters, and our analysis of ∼7.5 yr of LAT data reveals the first time detection of statistically significant γ -ray emission from CGRaBS J0225+1846. We generatemore » the broadband spectral energy distributions (SED) of all the objects, centering at the epoch of NuSTAR observations and reproduce them using a one-zone leptonic emission model. The optical−UV emission in all the objects can be explained by radiation from the accretion disk, whereas the X-ray to γ -ray windows of the SEDs are found to be dominated by inverse Compton scattering off the broad line region photons. All of them host black holes that are billions of solar masses. Comparing the accretion disk luminosity and the jet power of these sources with a large sample of blazars, we find them to occupy a high disk luminosity–jet power regime. We also investigate the X-ray spectral properties of the sources in detail with a major focus on studying the causes of soft X-ray deficit, a feature generally seen in high redshift radio-loud quasars. We summarize that this feature could be explained based on the intrinsic curvature in the jet emission rather than being due to the external effects predicted in earlier studies, such as host galaxy and/or warm absorption.« less

  8. Do Highly Effective Principals Also Have High Levels of Cultural Intelligence?

    ERIC Educational Resources Information Center

    Naughton, Whitney Michelle

    2010-01-01

    Purpose: The purpose of this study was to determine if elementary school principals who exhibit characteristics of highly effective principals also possess high levels of cultural intelligence. Methodology: Three instruments were used in this study, combining both qualitative and quantitative approaches to the collection of data. The first…

  9. Comparison of observation level versus 24-hour average atmospheric loading corrections in VLBI analysis

    NASA Astrophysics Data System (ADS)

    MacMillan, D. S.; van Dam, T. M.

    2009-04-01

    Variations in the horizontal distribution of atmospheric mass induce displacements of the Earth's surface. Theoretical estimates of the amplitude of the surface displacement indicate that the predicted surface displacement is often large enough to be detected by current geodetic techniques. In fact, the effects of atmospheric pressure loading have been detected in Global Positioning System (GPS) coordinate time series [van Dam et al., 1994; Dong et al., 2002; Scherneck et al., 2003; Zerbini et al., 2004] and very long baseline interferometery (VLBI) coordinates [Rabble and Schuh, 1986; Manabe et al., 1991; van Dam and Herring, 1994; Schuh et al., 2003; MacMillan and Gipson, 1994; and Petrov and Boy, 2004]. Some of these studies applied the atmospheric displacement at the observation level and in other studies, the predicted atmospheric and observed geodetic surface displacements have been averaged over 24 hours. A direct comparison of observation level and 24 hour corrections has not been carried out for VLBI to determine if one or the other approach is superior. In this presentation, we address the following questions: 1) Is it better to correct geodetic data at the observation level rather than applying corrections averaged over 24 hours to estimated geodetic coordinates a posteriori? 2) At the sub-daily periods, the atmospheric mass signal is composed of two components: a tidal component and a non-tidal component. If observation level corrections reduce the scatter of VLBI data more than a posteriori correction, is it sufficient to only model the atmospheric tides or must the entire atmospheric load signal be incorporated into the corrections? 3) When solutions from different geodetic techniques (or analysis centers within a technique) are combined (e.g., for ITRF2008), not all solutions may have applied atmospheric loading corrections. Are any systematic effects on the estimated TRF introduced when atmospheric loading is applied?

  10. Low-level information and high-level perception: the case of speech in noise.

    PubMed

    Nahum, Mor; Nelken, Israel; Ahissar, Merav

    2008-05-20

    Auditory information is processed in a fine-to-crude hierarchical scheme, from low-level acoustic information to high-level abstract representations, such as phonological labels. We now ask whether fine acoustic information, which is not retained at high levels, can still be used to extract speech from noise. Previous theories suggested either full availability of low-level information or availability that is limited by task difficulty. We propose a third alternative, based on the Reverse Hierarchy Theory (RHT), originally derived to describe the relations between the processing hierarchy and visual perception. RHT asserts that only the higher levels of the hierarchy are immediately available for perception. Direct access to low-level information requires specific conditions, and can be achieved only at the cost of concurrent comprehension. We tested the predictions of these three views in a series of experiments in which we measured the benefits from utilizing low-level binaural information for speech perception, and compared it to that predicted from a model of the early auditory system. Only auditory RHT could account for the full pattern of the results, suggesting that similar defaults and tradeoffs underlie the relations between hierarchical processing and perception in the visual and auditory modalities.

  11. Portable high speed photometry systems for observing occultations

    NASA Astrophysics Data System (ADS)

    Elliot, J. L.; Dunham, E. W.

    1986-09-01

    Ring orbit studies for Uranus have been particularly fruitful because of the ability, through occultations, to obtain data of high spatial resolution at the rate of 1 to 2 times per year. The occultation program at M.I.T. involves: (1) identifying the scientific questions that can be answered by occultation events, (2) predicting the zone of visibility for the useful events, (3) maintaining and improving a set of portable high-speed photometric systems, (4) obtaining the observations, and (5) reducing the data and interpreting the results. Two stellar occultations by Uranus occurred in May 1985, and were observed with a network of large telescopes that encompassed the Northern and Southern Hemispheres. Portable quartz-oscillator time standards were used at all observatories, and were calibrated before and after each event. Observations obtained form Cerro Tololo and McDonald Observatories of the 4 May and 24 May 1985 occultations by the Uranian rings clearly show a companion to the delta ring on both the immersion and emersion traces. The occultation by Ceres that occurred on 12 November 1984 was observed. Preliminary results give a mean diameter of 933 + or - 10 km, which implies a geometric albedo, Pv = 0.07 + or - 0.01 and a density 2.7 + or - 0.3 gm cu/cm. Hence Ceres is likely composed of silicate material throughout.

  12. Reducing the Impact of Sampling Bias in NASA MODIS and VIIRS Level 3 Satellite Derived IR SST Observations over the Arctic

    NASA Astrophysics Data System (ADS)

    Minnett, P. J.; Liu, Y.; Kilpatrick, K. A.

    2016-12-01

    Sea-surface temperature (SST) measurements by satellites in the northern hemisphere high latitudes confront several difficulties. Year-round prevalent clouds, effects near ice edges, and the relative small difference between SST and low-level cloud temperatures lead to a significant loss of infrared observations regardless of the more frequent polar satellite overpasses. Recent research (Liu and Minnett, 2016) identified sampling issues in the Level 3 NASA MODIS SST products when 4km observations are aggregated into global grids at different time and space scales, particularly in the Arctic, where a binary decision cloud mask designed for global data is often overly conservative at high latitudes and results in many gaps and missing data. This under sampling of some Arctic regions results in a warm bias in Level 3 products, likely a result of warmer surface temperature, more distant from the ice edge, being identified more frequently as cloud free. Here we present an improved method for cloud detection in the Arctic using a majority vote from an ensemble of four classifiers trained based on an Alternative Decision Tree (ADT) algorithm (Freund and Mason 1999, Pfahringer et. al. 2001). This new cloud classifier increases sampling of clear pixel by 50% in several regions and generally produces cooler monthly average SST fields in the ice-free Arctic, while still retaining the same error characteristics at 1km resolution relative to in situ observations. SST time series of 12 years of MODIS (Aqua and Terra) and more recently VIIRS sensors are compared and the improvements in errors and uncertainties resulting from better cloud screening for Level 3 gridded products are assessed and summarized.

  13. A high-resolution and observationally constrained OMI NO 2 satellite retrieval

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Goldberg, Daniel L.; Lamsal, Lok N.; Loughner, Christopher P.

    Here, this work presents a new high-resolution NO 2 dataset derived from the NASA Ozone Monitoring Instrument (OMI) NO 2 version 3.0 retrieval that can be used to estimate surface-level concentrations. The standard NASA product uses NO 2 vertical profile shape factors from a 1.25° × 1° (~110 km × 110 km) resolution Global Model Initiative (GMI) model simulation to calculate air mass factors, a critical value used to determine observed tropospheric NO 2 vertical columns. To better estimate vertical profile shape factors, we use a high-resolution (1.33 km × 1.33 km) Community Multi-scale Air Quality (CMAQ) model simulation constrained by in situmore » aircraft observations to recalculate tropospheric air mass factors and tropospheric NO 2 vertical columns during summertime in the eastern US. In this new product, OMI NO 2 tropospheric columns increase by up to 160% in city centers and decrease by 20–50 % in the rural areas outside of urban areas when compared to the operational NASA product. Our new product shows much better agreement with the Pandora NO 2 and Airborne Compact Atmospheric Mapper (ACAM) NO 2 spectrometer measurements acquired during the DISCOVER-AQ Maryland field campaign. Furthermore, the correlation between our satellite product and EPA NO 2 monitors in urban areas has improved dramatically: r 2 = 0.60 in the new product vs. r 2 = 0.39 in the operational product, signifying that this new product is a better indicator of surface concentrations than the operational product. Our work emphasizes the need to use both high-resolution and high-fidelity models in order to recalculate satellite data in areas with large spatial heterogeneities in NO x emissions. Although the current work is focused on the eastern US, the methodology developed in this work can be applied to other world regions to produce high-quality region-specific NO 2 satellite retrievals.« less

  14. A high-resolution and observationally constrained OMI NO 2 satellite retrieval

    DOE PAGES

    Goldberg, Daniel L.; Lamsal, Lok N.; Loughner, Christopher P.; ...

    2017-09-26

    Here, this work presents a new high-resolution NO 2 dataset derived from the NASA Ozone Monitoring Instrument (OMI) NO 2 version 3.0 retrieval that can be used to estimate surface-level concentrations. The standard NASA product uses NO 2 vertical profile shape factors from a 1.25° × 1° (~110 km × 110 km) resolution Global Model Initiative (GMI) model simulation to calculate air mass factors, a critical value used to determine observed tropospheric NO 2 vertical columns. To better estimate vertical profile shape factors, we use a high-resolution (1.33 km × 1.33 km) Community Multi-scale Air Quality (CMAQ) model simulation constrained by in situmore » aircraft observations to recalculate tropospheric air mass factors and tropospheric NO 2 vertical columns during summertime in the eastern US. In this new product, OMI NO 2 tropospheric columns increase by up to 160% in city centers and decrease by 20–50 % in the rural areas outside of urban areas when compared to the operational NASA product. Our new product shows much better agreement with the Pandora NO 2 and Airborne Compact Atmospheric Mapper (ACAM) NO 2 spectrometer measurements acquired during the DISCOVER-AQ Maryland field campaign. Furthermore, the correlation between our satellite product and EPA NO 2 monitors in urban areas has improved dramatically: r 2 = 0.60 in the new product vs. r 2 = 0.39 in the operational product, signifying that this new product is a better indicator of surface concentrations than the operational product. Our work emphasizes the need to use both high-resolution and high-fidelity models in order to recalculate satellite data in areas with large spatial heterogeneities in NO x emissions. Although the current work is focused on the eastern US, the methodology developed in this work can be applied to other world regions to produce high-quality region-specific NO 2 satellite retrievals.« less

  15. A high-resolution and observationally constrained OMI NO2 satellite retrieval

    NASA Astrophysics Data System (ADS)

    Goldberg, Daniel L.; Lamsal, Lok N.; Loughner, Christopher P.; Swartz, William H.; Lu, Zifeng; Streets, David G.

    2017-09-01

    This work presents a new high-resolution NO2 dataset derived from the NASA Ozone Monitoring Instrument (OMI) NO2 version 3.0 retrieval that can be used to estimate surface-level concentrations. The standard NASA product uses NO2 vertical profile shape factors from a 1.25° × 1° (˜ 110 km × 110 km) resolution Global Model Initiative (GMI) model simulation to calculate air mass factors, a critical value used to determine observed tropospheric NO2 vertical columns. To better estimate vertical profile shape factors, we use a high-resolution (1.33 km × 1.33 km) Community Multi-scale Air Quality (CMAQ) model simulation constrained by in situ aircraft observations to recalculate tropospheric air mass factors and tropospheric NO2 vertical columns during summertime in the eastern US. In this new product, OMI NO2 tropospheric columns increase by up to 160 % in city centers and decrease by 20-50 % in the rural areas outside of urban areas when compared to the operational NASA product. Our new product shows much better agreement with the Pandora NO2 and Airborne Compact Atmospheric Mapper (ACAM) NO2 spectrometer measurements acquired during the DISCOVER-AQ Maryland field campaign. Furthermore, the correlation between our satellite product and EPA NO2 monitors in urban areas has improved dramatically: r2 = 0.60 in the new product vs. r2 = 0.39 in the operational product, signifying that this new product is a better indicator of surface concentrations than the operational product. Our work emphasizes the need to use both high-resolution and high-fidelity models in order to recalculate satellite data in areas with large spatial heterogeneities in NOx emissions. Although the current work is focused on the eastern US, the methodology developed in this work can be applied to other world regions to produce high-quality region-specific NO2 satellite retrievals.

  16. High-speed imaging system for observation of discharge phenomena

    NASA Astrophysics Data System (ADS)

    Tanabe, R.; Kusano, H.; Ito, Y.

    2008-11-01

    A thin metal electrode tip instantly changes its shape into a sphere or a needlelike shape in a single electrical discharge of high current. These changes occur within several hundred microseconds. To observe these high-speed phenomena in a single discharge, an imaging system using a high-speed video camera and a high repetition rate pulse laser was constructed. A nanosecond laser, the wavelength of which was 532 nm, was used as the illuminating source of a newly developed high-speed video camera, HPV-1. The time resolution of our system was determined by the laser pulse width and was about 80 nanoseconds. The system can take one hundred pictures at 16- or 64-microsecond intervals in a single discharge event. A band-pass filter at 532 nm was placed in front of the camera to block the emission of the discharge arc at other wavelengths. Therefore, clear images of the electrode were recorded even during the discharge. If the laser was not used, only images of plasma during discharge and thermal radiation from the electrode after discharge were observed. These results demonstrate that the combination of a high repetition rate and a short pulse laser with a high speed video camera provides a unique and powerful method for high speed imaging.

  17. Detection of the High-Level Aminoglycoside Resistance Gene aph(2")-Ib in Enterococcus faecium

    PubMed Central

    Kao, Susan J.; You, Il; Clewell, Don B.; Donabedian, Susan M.; Zervos, Marcus J.; Petrin, Joanne; Shaw, Karen J.; Chow, Joseph W.

    2000-01-01

    A new high-level gentamicin resistance gene, designated aph(2")-Ib, was cloned from Enterococcus faecium SF11770. The deduced amino acid sequence of the 897-bp open reading frame of aph(2")-Ib shares homology with the aminoglycoside-modifying enzymes AAC(6′)-APH(2"), APH(2")-Ic, and APH(2")-Id. The observed phosphotransferase activity is designated APH(2")-Ib. PMID:10991878

  18. The sleep of elite athletes at sea level and high altitude: a comparison of sea-level natives and high-altitude natives (ISA3600).

    PubMed

    Roach, Gregory D; Schmidt, Walter F; Aughey, Robert J; Bourdon, Pitre C; Soria, Rudy; Claros, Jesus C Jimenez; Garvican-Lewis, Laura A; Buchheit, Martin; Simpson, Ben M; Hammond, Kristal; Kley, Marlen; Wachsmuth, Nadine; Gore, Christopher J; Sargent, Charli

    2013-12-01

    Altitude exposure causes acute sleep disruption in non-athletes, but little is known about its effects in elite athletes. The aim of this study was to examine the effects of altitude on two groups of elite athletes, that is, sea-level natives and high-altitude natives. Sea-level natives were members of the Australian under-17 soccer team (n=14). High-altitude natives were members of a Bolivian under-20 club team (n=12). Teams participated in an 18-day (19 nights) training camp in Bolivia, with 6 nights at near sea level in Santa Cruz (430 m) and 13 nights at high altitude in La Paz (3600 m). Sleep was assessed on every day/night using activity monitors. The Australians' sleep was shorter, and of poorer quality, on the first night at altitude compared with sea level. Sleep quality returned to normal by the end of the first week at altitude, but sleep quantity had still not stabilised at its normal level after 2 weeks. The quantity and quality of sleep obtained by the Bolivians was similar, or greater, on all nights at altitude compared with sea level. The Australians tended to obtain more sleep than the Bolivians at sea level and altitude, but the quality of the Bolivians' sleep tended to be better than that of the Australians at altitude. Exposure to high altitude causes acute and chronic disruption to the sleep of elite athletes who are sea-level natives, but it does not affect the sleep of elite athletes who are high-altitude natives.

  19. Using satellite observations in performance evaluation for regulatory air quality modeling: Comparison with ground-level measurements

    NASA Astrophysics Data System (ADS)

    Odman, M. T.; Hu, Y.; Russell, A.; Chai, T.; Lee, P.; Shankar, U.; Boylan, J.

    2012-12-01

    Regulatory air quality modeling, such as State Implementation Plan (SIP) modeling, requires that model performance meets recommended criteria in the base-year simulations using period-specific, estimated emissions. The goal of the performance evaluation is to assure that the base-year modeling accurately captures the observed chemical reality of the lower troposphere. Any significant deficiencies found in the performance evaluation must be corrected before any base-case (with typical emissions) and future-year modeling is conducted. Corrections are usually made to model inputs such as emission-rate estimates or meteorology and/or to the air quality model itself, in modules that describe specific processes. Use of ground-level measurements that follow approved protocols is recommended for evaluating model performance. However, ground-level monitoring networks are spatially sparse, especially for particulate matter. Satellite retrievals of atmospheric chemical properties such as aerosol optical depth (AOD) provide spatial coverage that can compensate for the sparseness of ground-level measurements. Satellite retrievals can also help diagnose potential model or data problems in the upper troposphere. It is possible to achieve good model performance near the ground, but have, for example, erroneous sources or sinks in the upper troposphere that may result in misleading and unrealistic responses to emission reductions. Despite these advantages, satellite retrievals are rarely used in model performance evaluation, especially for regulatory modeling purposes, due to the high uncertainty in retrievals associated with various contaminations, for example by clouds. In this study, 2007 was selected as the base year for SIP modeling in the southeastern U.S. Performance of the Community Multiscale Air Quality (CMAQ) model, at a 12-km horizontal resolution, for this annual simulation is evaluated using both recommended ground-level measurements and non-traditional satellite

  20. Highly elevated atmospheric levels of volatile organic compounds in the Uintah Basin, Utah.

    PubMed

    Helmig, D; Thompson, C R; Evans, J; Boylan, P; Hueber, J; Park, J-H

    2014-05-06

    Oil and natural gas production in the Western United States has grown rapidly in recent years, and with this industrial expansion, growing environmental concerns have arisen regarding impacts on water supplies and air quality. Recent studies have revealed highly enhanced atmospheric levels of volatile organic compounds (VOCs) from primary emissions in regions of heavy oil and gas development and associated rapid photochemical production of ozone during winter. Here, we present surface and vertical profile observations of VOC from the Uintah Basin Winter Ozone Studies conducted in January-February of 2012 and 2013. These measurements identify highly elevated levels of atmospheric alkane hydrocarbons with enhanced rates of C2-C5 nonmethane hydrocarbon (NMHC) mean mole fractions during temperature inversion events in 2013 at 200-300 times above the regional and seasonal background. Elevated atmospheric NMHC mole fractions coincided with build-up of ambient 1-h ozone to levels exceeding 150 ppbv (parts per billion by volume). The total annual mass flux of C2-C7 VOC was estimated at 194 ± 56 × 10(6) kg yr(-1), equivalent to the annual VOC emissions of a fleet of ∼100 million automobiles. Total annual fugitive emission of the aromatic compounds benzene and toluene, considered air toxics, were estimated at 1.6 ± 0.4 × 10(6) and 2.0 ± 0.5 × 10(6) kg yr(-1), respectively. These observations reveal a strong causal link between oil and gas emissions, accumulation of air toxics, and significant production of ozone in the atmospheric surface layer.

  1. High zenith angle observations of PKS 2155-304 with the MAGIC-I telescope

    NASA Astrophysics Data System (ADS)

    Aleksić, J.; Alvarez, E. A.; Antonelli, L. A.; Antoranz, P.; Asensio, M.; Backes, M.; Barres de Almeida, U.; Barrio, J. A.; Bastieri, D.; Becerra González, J.; Bednarek, W.; Berdyugin, A.; Berger, K.; Bernardini, E.; Biland, A.; Blanch, O.; Bock, R. K.; Boller, A.; Bonnoli, G.; Borla Tridon, D.; Braun, I.; Bretz, T.; Cañellas, A.; Carmona, E.; Carosi, A.; Colin, P.; Colombo, E.; Contreras, J. L.; Cortina, J.; Cossio, L.; Covino, S.; Dazzi, F.; De Angelis, A.; De Caneva, G.; De Cea del Pozo, E.; De Lotto, B.; Delgado Mendez, C.; Diago Ortega, A.; Doert, M.; Domínguez, A.; Dominis Prester, D.; Dorner, D.; Doro, M.; Eisenacher, D.; Elsaesser, D.; Ferenc, D.; Fonseca, M. V.; Font, L.; Fruck, C.; García López, R. J.; Garczarczyk, M.; Garrido, D.; Giavitto, G.; Godinović, N.; Gozzini, S. R.; Hadasch, D.; Häfner, D.; Herrero, A.; Hildebrand, D.; Höhne-Mönch, D.; Hose, J.; Hrupec, D.; Jogler, T.; Kellermann, H.; Klepser, S.; Krähenbühl, T.; Krause, J.; Kushida, J.; La Barbera, A.; Lelas, D.; Leonardo, E.; Lewandowska, N.; Lindfors, E.; Lombardi, S.; López, M.; López, R.; López-Oramas, A.; Lorenz, E.; Makariev, M.; Maneva, G.; Mankuzhiyil, N.; Mannheim, K.; Maraschi, L.; Marcote, B.; Mariotti, M.; Martínez, M.; Mazin, D.; Meucci, M.; Miranda, J. M.; Mirzoyan, R.; Moldón, J.; Moralejo, A.; Munar-Adrover, P.; Niedzwiecki, A.; Nieto, D.; Nilsson, K.; Nowak, N.; Orito, R.; Paiano, S.; Paneque, D.; Paoletti, R.; Pardo, S.; Paredes, J. M.; Partini, S.; Perez-Torres, M. A.; Persic, M.; Peruzzo, L.; Pilia, M.; Pochon, J.; Prada, F.; Prada Moroni, P. G.; Prandini, E.; Puerto Gimenez, I.; Puljak, I.; Reichardt, I.; Reinthal, R.; Rhode, W.; Ribó, M.; Rico, J.; Rügamer, S.; Saggion, A.; Saito, K.; Saito, T. Y.; Salvati, M.; Satalecka, K.; Scalzotto, V.; Scapin, V.; Schultz, C.; Schweizer, T.; Shayduk, M.; Shore, S. N.; Sillanpää, A.; Sitarek, J.; Snidaric, I.; Sobczynska, D.; Spanier, F.; Spiro, S.; Stamatescu, V.; Stamerra, A.; Steinke, B.; Storz, J.; Strah, N.; Sun, S.; Surić, T.; Takalo, L.; Takami, H.; Tavecchio, F.; Temnikov, P.; Terzić, T.; Tescaro, D.; Teshima, M.; Tibolla, O.; Torres, D. F.; Treves, A.; Uellenbeck, M.; Vankov, H.; Vogler, P.; Wagner, R. M.; Weitzel, Q.; Zabalza, V.; Zandanel, F.; Zanin, R.

    2012-08-01

    Context. The high frequency peaked BL Lac PKS 2155-304 with a redshift of z = 0.116 was discovered in 1997 in the very high energy (VHE, E > 100 GeV) γ-ray range by the University of Durham Mark VI γ-ray Cherenkov telescope in Australia with a flux corresponding to 20% of the Crab Nebula flux. It was later observed and detected with high significance by the southern Cherenkov observatory H.E.S.S. establishing this source as the best studied southern TeV blazar. Detection from the northern hemisphere is difficult due to challenging observation conditions under large zenith angles. In July 2006, the H.E.S.S. collaboration reported an extraordinary outburst of VHE γ-emission. During the outburst, the VHE γ-ray emission was found to be variable on the time scales of minutes and with a mean flux of ~7 times the flux observed from the Crab Nebula. Follow-up observations with the MAGIC-I standalone Cherenkov telescope were triggered by this extraordinary outburst and PKS 2155-304 was observed between 28 July to 2 August 2006 for 15 h at large zenith angles. Aims: We studied the behavior of the source after its extraordinary flare. Furthermore, we developed an analysis method in order to analyze these data taken under large zenith angles. Methods: Here we present an enhanced analysis method for data taken at high zenith angles. We developed improved methods for event selection that led to a better background suppression. Results: The quality of the results presented here is superior to the results presented previously for this data set: detection of the source on a higher significance level and a lower analysis threshold. The averaged energy spectrum we derived has a spectral index of (-3.5 ± 0.2) above 400 GeV, which is in good agreement with the spectral shape measured by H.E.S.S. during the major flare on MJD 53 944. Furthermore, we present the spectral energy distribution modeling of PKS 2155-304. With our observations we increased the duty cycle of the source

  2. The protective effects of high-education levels on cognition in different stages of multiple sclerosis.

    PubMed

    Rimkus, Carolina de Medeiros; Avolio, Isabella Maria Bello; Miotto, Eliane Correa; Pereira, Samira Apostolos; Mendes, Maria Fernanda; Callegaro, Dagoberto; Leite, Claudia da Costa

    2018-05-01

    Low-education attainment is associated with worse cognitive performance in multiple sclerosis (MS) patients, and possibly with a lower cognitive reserve and/or increased inflammatory activity. Cognitive reserve refers to the capability of a source of intellectual enrichment in attenuating a negative effect of a disease-related factor; while the inflammatory activity is often related to T2-lesion load (T2-LL) increase. To disentangle the effects of cognitive reserve and an increased T2-LL in MS-patients with low-education levels. The study included 136 MS patients and 65 healthy-controls, divided in low-education (12 years or less of school education without obtaining any technical superior degree) and high-education (more than 12 years of school education with technical or superior degree) groups. An extensive battery of neuropsychological tests was applied examining intelligence quotient and six cognitive domains. Test results were z-scored and subjects with z-scores ≤ -1.5 in two or more domains were considered cognitively impaired. To test the factors associated with worse cognitive performance, regression models were applied using average cognition as target; education level, Expanded Disability Status Scale (EDSS), T2-LL, disease duration, age of disease onset, age and gender as predictors. We also tested the correlation between T2-LL and cognition in the groups. To investigate the role of education level as a source of intellectual enrichment/cognitive reserve in different stages of MS, we sub-divided the MS patients in three groups according to the disease duration (less than 5 years, between 5 and 10 years and more than 10 years). Worse average cognition was associated with low-education level, higher T2-LL and male gender. A higher frequency of cognitively impaired patients was observed in MS patients with low-education level, in all stages of the disease. In patients with a disease duration shorter than five years, there was a lower correlation between

  3. Size distributions of air showers accompanied with high energy gamma ray bundles observed at Mt. Chacaltaya

    NASA Technical Reports Server (NTRS)

    Matano, T.; Machida, M.; Tsuchima, I.; Kawasumi, N.; Honda, K.; Hashimoto, K.; Martinic, N.; Zapata, J.; Navia, C. E.; Aquirre, C.

    1985-01-01

    Size distributions of air showers accompanied with bundle of high energy gamma rays and/or large size bursts under emulsion chambers, to study the composition of primary cosmic rays and also characteristics of high energy nuclear interaction. Air showers initiated by particles with a large cross section of interaction may develop from narrow region of the atmosphere near the top. Starting levels of air showers by particles with smaller cross section fluctuate in wider region of the atmosphere. Air showers of extremely small size accompanied with bundle of gamma rays may be ones initiated by protons at lower level after penetrating deep atmosphere without interaction. It is determined that the relative size distribution according to the total energy of bundle of gamma rays and the total burst size observed under 15 cm lead absorber.

  4. IUE observations of blue halo high luminosity stars

    NASA Technical Reports Server (NTRS)

    Hack, M.; Franco, M. L.; Stalio, R.

    1981-01-01

    Two high luminosity population II blue stars of high galactic latitude, BD+33 deg 2642 and HD 137569 were observed at high resolution. The stellar spectra show the effect of mass loss in BD+33 deg 2642 and abnormally weak metallic lines in HD 137569. The interstellar lines in the direction of BD+33 deg 2642, which lies at a height z greater than or equal to 6.2 kpc from the galactic plane, are split into two components. No high ionization stages are found at the low velocity component; nor can they be detected in the higher velocity clouds because of mixing with the corresponding stellar/circumstellar lines.

  5. Thermomechanical treatment of 2124 PM aluminum alloys with low and high dispersoid levels

    NASA Technical Reports Server (NTRS)

    Sarkar, B.; Lisagor, W. B.

    1986-01-01

    The effects of thermomechanical treatment (TMT) on the mechanical properties and metallurgical structure of 2124 powder metallurgy aluminum alloys prepared from rapidly solidified powders were investigated. The alloys were prepared by using a standard canning/vacuum degassing/hot consolidation/extrusion sequence. Two compositions, with manganese contents of 0.5 and 1.5 percent, were investigated to examine the effects of low and high dispersoid levels. The results indicate that significant improvements in strength can be accomplished through TMT for this PM alloy system with little loss in toughness. The increase in strength observed is attributed to the presence of much finer, more homogeneous S-prime precipitation than that observed without TMT. Rolling deformation at room temperature resulted in some tendency for nonuniform (planar) deformation and resulted in slightly lower notch strength values. The lower notch strengths observed in the higher manganese composition were attributed to the coarser, more dense dispersoids observed in this material.

  6. High level intelligent control of telerobotics systems

    NASA Technical Reports Server (NTRS)

    Mckee, James

    1988-01-01

    A high level robot command language is proposed for the autonomous mode of an advanced telerobotics system and a predictive display mechanism for the teleoperational model. It is believed that any such system will involve some mixture of these two modes, since, although artificial intelligence can facilitate significant autonomy, a system that can resort to teleoperation will always have the advantage. The high level command language will allow humans to give the robot instructions in a very natural manner. The robot will then analyze these instructions to infer meaning so that is can translate the task into lower level executable primitives. If, however, the robot is unable to perform the task autonomously, it will switch to the teleoperational mode. The time delay between control movement and actual robot movement has always been a problem in teleoperations. The remote operator may not actually see (via a monitor) the results of high actions for several seconds. A computer generated predictive display system is proposed whereby the operator can see a real-time model of the robot's environment and the delayed video picture on the monitor at the same time.

  7. Comparison between SAGE II and ISCCP high-level clouds. 1: Global and zonal mean cloud amounts

    NASA Technical Reports Server (NTRS)

    Liao, Xiaohan; Rossow, William B.; Rind, David

    1995-01-01

    Global high-level clouds identified in Stratospheric Aerosol and Gas Experiment II (SAGE II) occultation measurements for January and July in the period 1985 to 1990 are compared with near-nadir-looking observations from the International Satellite Cloud Climatology Project (ISCCP). Global and zonal mean high-level cloud amounts from the two data sets agree very well, if clouds with layer extinction coefficients of less than 0.008/km at 1.02 micrometers wavelength are removed from the SAGE II results and all detected clouds are interpreted to have an average horizontal size of about 75 km along the 200 km transimission path length of the SAGE II observations. The SAGE II results are much more sensitive to variations of assumed cloud size than to variations of detection threshold. The geographical distribution of cloud fractions shows good agreement, but systematic regional differences also indicate that the average cloud size varies somewhat among different climate regimes. The more sensitive SAGE II results show that about one third of all high-level clouds are missed by ISCCP but that these clouds have very low optical thicknesses (less than 0.1 at 0.6 micrometers wavelength). SAGE II sampling error in monthly zonal cloud fraction is shown to produce no bias, to be less than the intraseasonal natural variability, but to be comparable with the natural variability at longer time scales.

  8. Ozone photochemical production in urban Shanghai, China: Analysis based on ground level observations

    NASA Astrophysics Data System (ADS)

    Ran, Liang; Zhao, Chunsheng; Geng, Fuhai; Tie, Xuexi; Tang, Xu; Peng, Li; Zhou, Guangqiang; Yu, Qiong; Xu, Jianmin; Guenther, Alex

    2009-08-01

    Ozone and its precursors were measured from 15 June 2006 to 14 June 2007 at an urban site in Shanghai and used to characterize photochemical oxidant production in this region. During the observation period, ozone displays a seasonal variation with a maximum in spring. Observed nitrogen oxides (NOx) and carbon monoxide (CO) reached a maximum in winter and a minimum in summer. NOx and CO has a similar double-peak diurnal cycle, implying that they are largely of motor vehicle origin. Total nonmethane organic compounds (NMOC) concentrations averaged over the morning, and the 24-hour periods have a large day-to-day variation with no apparent seasonal cycle. Aromatics play a dominant role in contributing to total NMOC reactivity and ozone-forming potential. Anthropogenic NMOC of diverse sources are major components of total NMOC and consist mainly of moderate and low reactivity species. In contrast, relatively low levels of biogenic NMOC concentrations were observed in urban Shanghai. The early morning NMOC/NOx ratios are typically below 8:1 with an average of around 4:1, indicating that the sampling location is situated in a NMOC-limited regime. Model simulations confirm that potential photochemical ozone production in Shanghai is NMOC-sensitive. It is presently difficult to predict the impact of future human activities, such as the increase of automobiles and vegetation-covered landscapes and the reduction of aerosol on ozone pollution in the fast developing megacities of China, and additional studies are needed to better understand the highly nonlinear ozone problem.

  9. Parallel Processing at the High School Level.

    ERIC Educational Resources Information Center

    Sheary, Kathryn Anne

    This study investigated the ability of high school students to cognitively understand and implement parallel processing. Data indicates that most parallel processing is being taught at the university level. Instructional modules on C, Linux, and the parallel processing language, P4, were designed to show that high school students are highly…

  10. Dissemination of high-level mupirocin-resistant CC22-MRSA-IV in Saxony

    PubMed Central

    Monecke, Stefan; Ruppelt-Lorz, Antje; Müller, Elke; Reissig, Annett; Thürmer, Alexander; Shore, Anna C.; Coleman, David C.; Ehricht, Ralf; Jatzwauk, Lutz

    2017-01-01

    Mupirocin is used for eradicating methicillin-resistant S. aureus (MRSA) in nasal colonization. A plasmid-borne gene, mupA, is associated with high-level mupirocin resistance. Despite the fact that, among all MRSA from a tertiary care center in the German state of Saxony, the prevalence of mupA, encoding high-level mupirocin resistance, was approximately 1% over a 15-year period from 2000–2015, a sharp increase to nearly 20% was observed in 2016/2017. DNA microarray profiling revealed that this was due to the dissemination of a variant of CC22-MRSA-IV (“Barnim Epidemic Strain” or “UK-EMRSA-15”), which, in addition to mecA, harbors mupA, aacA-aphD, qacA, and – in most isolates – erm(C). In order to prevent therapy failures and a further spread of this strain, the use of mupirocin should be more stringently controlled as well as guided by susceptibility testing. In addition, MRSA decolonization regimens that rely on other substances, such as betaisodona, polyhexanide or octenidine, should be considered. PMID:29184755

  11. Do observed levels of exploitation from consumption-oriented and trophy-oriented fisheries reduce relative stock densities of Muskellunge below target levels in northern Wisconsin?

    USGS Publications Warehouse

    Faust, Matthew D.; Hansen, Michael J.

    2017-01-01

    Muskellunge anglers desire to catch large fish, and release rates by recreational anglers often approach 100% (Isermann et al. 2011). Muskellunge are also a culturally significant fish for Chippewa tribes and support a subsistence spearing fishery in Wisconsin’s Ceded Territory (Erickson 2007). Although Muskellunge populations within the state’s Ceded Territory are exposed to both angling and spearing fishery exploitation, Faust and Hansen (2016) suggested that under certain conditions (e.g., high minimum length limits (MLL) and low spearing exploitation) Muskellunge fisheries with disparate motivations could coexist (i.e., sufficient numbers of large individuals remained despite harvest from consumptive fishery), but noted that larger declines in trophy Muskellunge abundance were predicted at lower MLLs (e.g., 102-cm). Fisheries managers with the Wisconsin Department of Natural Resources (WDNR) wished to further understand how specific relative stock densities (RSD), used by the WDNR to define and monitor trophy Muskellunge fisheries, are reduced at exploitation rates commonly experienced by populations in northern Wisconsin. Similarly, understanding how trophy Muskellunge abundance may have declined under the previous statewide MLL (i.e., 86-cm) at these levels of exploitation was also desired. Thus, our objectives were to 1) determine if observed levels of angling and spearing exploitation reduced predicted RSD indices below thresholds used by the WDNR to define trophy Muskellunge fisheries for three typical Muskellunge growth potentials in northern Wisconsin across a variety of MLLs; and 2) quantify how numbers of trophy Muskellunge declined under an 86-cm MLL at observed levels of exploitation.

  12. Very-High-Energy γ-Ray Observations of the Blazar 1ES 2344+514 with VERITAS

    NASA Astrophysics Data System (ADS)

    Allen, C.; Archambault, S.; Archer, A.; Benbow, W.; Bird, R.; Bourbeau, E.; Brose, R.; Buchovecky, M.; Buckley, J. H.; Bugaev, V.; Cardenzana, J. V.; Cerruti, M.; Chen, X.; Christiansen, J. L.; Connolly, M. P.; Cui, W.; Daniel, M. K.; Eisch, J. D.; Falcone, A.; Feng, Q.; Fernandez-Alonso, M.; Finley, J. P.; Fleischhack, H.; Flinders, A.; Fortson, L.; Furniss, A.; Gillanders, G. H.; Griffin, S.; Grube, J.; Hütten, M.; Håkansson, N.; Hanna, D.; Hervet, O.; Holder, J.; Hughes, G.; Humensky, T. B.; Johnson, C. A.; Kaaret, P.; Kar, P.; Kelley-Hoskins, N.; Kertzman, M.; Kieda, D.; Krause, M.; Krennrich, F.; Kumar, S.; Lang, M. J.; Maier, G.; McArthur, S.; McCann, A.; Meagher, K.; Moriarty, P.; Mukherjee, R.; Nguyen, T.; Nieto, D.; O'Brien, S.; de Bhróithe, A. O'Faoláin; Ong, R. A.; Otte, A. N.; Park, N.; Petrashyk, A.; Pichel, A.; Pohl, M.; Popkow, A.; Pueschel, E.; Quinn, J.; Ragan, K.; Reynolds, P. T.; Richards, G. T.; Roache, E.; Rovero, A. C.; Rulten, C.; Sadeh, I.; Santander, M.; Sembroski, G. H.; Shahinyan, K.; Telezhinsky, I.; Tucci, J. V.; Tyler, J.; Wakely, S. P.; Weinstein, A.; Wilhelm, A.; Williams, D. A.

    2017-10-01

    We present very-high-energy γ-ray observations of the BL Lac object 1ES 2344+514 taken by the Very Energetic Radiation Imaging Telescope Array System between 2007 and 2015. 1ES 2344+514 is detected with a statistical significance above the background of 20.8σ in 47.2 h (livetime) of observations, making this the most comprehensive very-high-energy study of 1ES 2344+514 to date. Using these observations, the temporal properties of 1ES 2344+514 are studied on short and long times-scales. We fit a constant-flux model to nightly and seasonally binned light curves and apply a fractional variability test to determine the stability of the source on different time-scales. We reject the constant-flux model for the 2007-2008 and 2014-2015 nightly binned light curves and for the long-term seasonally binned light curve at the >3σ level. The spectra of the time-averaged emission before and after correction for attenuation by the extragalactic background light are obtained. The observed time-averaged spectrum above 200 GeV is satisfactorily fitted (χ2/NDF = 7.89/6) by a power-law function with an index Γ = 2.46 ± 0.06stat ± 0.20sys and extends to at least 8 TeV. The extragalactic-background-light-deabsorbed spectrum is adequately fit (χ2/NDF = 6.73/6) by a power-law function with an index Γ = 2.15 ± 0.06stat ± 0.20sys while an F-test indicates that the power law with an exponential cut-off function provides a marginally better fit (χ2/NDF = 2.56/5) at the 2.1σ level. The source location is found to be consistent with the published radio location and its spatial extent is consistent with a point source.

  13. Reference commercial high-level waste glass and canister definition

    NASA Astrophysics Data System (ADS)

    Slate, S. C.; Ross, W. A.; Partain, W. L.

    1981-09-01

    Technical data and performance characteristics of a high level waste glass and canister intended for use in the design of a complete waste encapsulation package suitable for disposal in a geologic repository are presented. The borosilicate glass contained in the stainless steel canister represents the probable type of high level waste product that is produced in a commercial nuclear-fuel reprocessing plant. Development history is summarized for high level liquid waste compositions, waste glass composition and characteristics, and canister design. The decay histories of the fission products and actinides (plus daughters) calculated by the ORIGEN-II code are presented.

  14. Endotoxin levels correlate positively with a sedentary lifestyle and negatively with highly trained subjects

    PubMed Central

    2010-01-01

    Introduction A sedentary lifestyle increases the risk of developing cardiovascular disease, obesity, and diabetes. This phenomenon is supported by recent studies suggesting a chronic, low-grade inflammation status. Endotoxin derived from gut flora may be key to the development of inflammation by stimulating the secretion of inflammatory factors. This study aimed to examine plasma inflammatory markers and endotoxin levels in individuals with a sedentary lifestyle and/or in highly trained subjects at rest. Methods: Fourteen male subjects (sedentary lifestyle n = 7; highly trained subjects n = 7) were recruited. Blood samples were collected after an overnight fast (~12 h). The plasmatic endotoxin, plasminogen activator inhibitor type-1 (PAI-1), monocyte chemotactic protein-1 (MCP1), ICAM/CD54, VCAM/CD106 and lipid profile levels were determined. Results Endotoxinemia was lower in the highly trained subject group relative to the sedentary subjects (p < 0.002). In addition, we observed a positive correlation between endotoxin and PAI-1 (r = 0.85, p < 0.0001), endotoxin and total cholesterol (r = 0.65; p < 0.01), endotoxin and LDL-c (r = 0.55; p < 0.049) and endotoxin and TG levels (r = 0.90; p < 0.0001). The plasma levels of MCP-1, ICAM/CD54 and VCAM/CD106 did not differ. Conclusion These results indicate that a lifestyle associated with high-intensity and high-volume exercise induces favorable changes in chronic low-grade inflammation markers and may reduce the risk for diseases such as obesity, diabetes and cardiovascular diseases. PMID:20684772

  15. Stable superconducting magnet. [high current levels below critical temperature

    NASA Technical Reports Server (NTRS)

    Boom, R. W. (Inventor)

    1967-01-01

    Operation of a superconducting magnet is considered. A method is described for; (1) obtaining a relatively high current in a superconducting magnet positioned in a bath of a gas refrigerant; (2) operating a superconducting magnet at a relatively high current level without training; and (3) operating a superconducting magnet containing a plurality of turns of a niobium zirconium wire at a relatively high current level without training.

  16. High-level radioactive waste management alternatives

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1974-05-01

    A summary of a comprehensive overview study of potential alternatives for long-term management of high-level radioactive waste is presented. The concepts studied included disposal in geologic formations, disposal in seabeds, disposal in ice caps, disposal into space, and elimination by transmutation. (TFD)

  17. The sleep of elite athletes at sea level and high altitude: a comparison of sea-level natives and high-altitude natives (ISA3600)

    PubMed Central

    Roach, Gregory D; Schmidt, Walter F; Aughey, Robert J; Bourdon, Pitre C; Soria, Rudy; Claros, Jesus C Jimenez; Garvican-Lewis, Laura A; Buchheit, Martin; Simpson, Ben M; Hammond, Kristal; Kley, Marlen; Wachsmuth, Nadine; Gore, Christopher J; Sargent, Charli

    2013-01-01

    Background Altitude exposure causes acute sleep disruption in non-athletes, but little is known about its effects in elite athletes. The aim of this study was to examine the effects of altitude on two groups of elite athletes, that is, sea-level natives and high-altitude natives. Methods Sea-level natives were members of the Australian under-17 soccer team (n=14). High-altitude natives were members of a Bolivian under-20 club team (n=12). Teams participated in an 18-day (19 nights) training camp in Bolivia, with 6 nights at near sea level in Santa Cruz (430 m) and 13 nights at high altitude in La Paz (3600 m). Sleep was assessed on every day/night using activity monitors. Results The Australians’ sleep was shorter, and of poorer quality, on the first night at altitude compared with sea level. Sleep quality returned to normal by the end of the first week at altitude, but sleep quantity had still not stabilised at its normal level after 2 weeks. The quantity and quality of sleep obtained by the Bolivians was similar, or greater, on all nights at altitude compared with sea level. The Australians tended to obtain more sleep than the Bolivians at sea level and altitude, but the quality of the Bolivians’ sleep tended to be better than that of the Australians at altitude. Conclusions Exposure to high altitude causes acute and chronic disruption to the sleep of elite athletes who are sea-level natives, but it does not affect the sleep of elite athletes who are high-altitude natives. PMID:24282197

  18. Treatment strategy for metastatic prostate cancer with extremely high PSA level: reconsidering the value of vintage therapy.

    PubMed

    Yamada, Yasutaka; Sakamoto, Shinichi; Amiya, Yoshiyasu; Sasaki, Makoto; Shima, Takayuki; Komiya, Akira; Suzuki, Noriyuki; Akakura, Koichiro; Ichikawa, Tomohiko; Nakatsu, Hiroomi

    2018-05-04

    The prognostic significance of initial prostate-specific antigen (PSA) level for metastatic prostate cancer remains uncertain. We investigated the differences in prognosis and response to hormonal therapies of metastatic prostate cancer patients according to initial PSA levels. We analyzed 184 patients diagnosed with metastatic prostate cancer and divided them into three PSA level groups as follows: low (<100 ng ml -1 ), intermediate (100-999 ng ml -1 ), and high (≥1000 ng ml -1 ). All patients received androgen deprivation therapy (ADT) immediately. We investigated PSA progression-free survival (PFS) for first-line ADT and overall survival (OS) within each of the three groups. Furthermore, we analyzed response to antiandrogen withdrawal (AW) and alternative antiandrogen (AA) therapies after development of castration-resistant prostate cancer (CRPC). No significant differences in OS were observed among the three groups (P = 0.654). Patients with high PSA levels had significantly short PFS for first-line ADT (P = 0.037). Conversely, patients in the high PSA level group had significantly longer PFS when treated with AW than those in the low PSA level group (P = 0.047). Furthermore, patients with high PSA levels had significantly longer PFS when provided with AA therapy (P = 0.049). PSA responders to AW and AA therapies had significantly longer survival after CRPC development than nonresponders (P = 0.011 and P < 0.001, respectively). Thus, extremely high PSA level predicted favorable response to vintage sequential ADT and AW. The current data suggest a novel aspect of extremely high PSA value as a favorable prognostic marker after development of CRPC.

  19. Analysis of Cyberbullying Sensitivity Levels of High School Students and Their Perceived Social Support Levels

    ERIC Educational Resources Information Center

    Akturk, Ahmet Oguz

    2015-01-01

    Purpose: The purpose of this paper is to determine the cyberbullying sensitivity levels of high school students and their perceived social supports levels, and analyze the variables that predict cyberbullying sensitivity. In addition, whether cyberbullying sensitivity levels and social support levels differed according to gender was also…

  20. Solidification of Savannah River plant high level waste

    NASA Astrophysics Data System (ADS)

    Maher, R.; Shafranek, L. F.; Kelley, J. A.; Zeyfang, R. W.

    1981-11-01

    Authorization for construction of the Defense Waste Processing Facility (DWPF) is expected in FY-83. The optimum time for stage 2 authorization is about three years later. Detailed design and construction will require approximately five years for stage 1, with stage 2 construction completed about two to three years later. Production of canisters of waste glass would begin in 1988, and the existing backlog of high level waste sludge stored at SRP would be worked off by about the year 2000. Stage 2 operation could begin in 1990. The technology and engineering are ready for construction and eventual operation of the DWPF for immobilizing high level radioactive waste at Savannah River Plant (SRP). Proceeding with this project will provide the public, and the leadership of this country, with a crucial demonstration that a major quanitity of existing high level nuclear wastes can be safely and permanently immobilized.

  1. High serum level of retinol and α-tocopherol affords protection against oral cancer in a multiethnic population.

    PubMed

    Athirajan, Vimmitra; Razak, Ishak Abdul; Thurairajah, Nalina; Ghani, Wan Maria Nabillah; Ching, Helen-Ng Lee; Yang, Yi-Hsin; Peng, Karen-Ng Lee; Abdul Rahman, Zainal Ariff; Mustafa, Wan Mahadzir Wan; Abraham, Mannil Thomas; Kiong, Tay Keng; Mun, Yuen Kar; Jalil, Norma; Zain, Rosnah Binti

    2014-01-01

    A comparative cross-sectional study involving oral cancer patients and healthy individuals was designed to investigate associations between retinol, α-tocopherol and β-carotene with the risk of oral cancer. This study included a total of 240 matched cases and controls where subjects were selected from the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS). Retinol, α-tocopherol and β-carotene levels and intake were examined by high-performance liquid chromatography (HPLC) and food frequency questionnaire (FFQ) respectively. It was found that results from the two methods applied did not correlate, so that further analysis was done using the HPLC method utilising blood serum. Serum levels of retinol and α-tocopherol among cases (0.177±0.081, 1.649±1.670μg/ml) were significantly lower than in controls (0.264±0.137, 3.225±2.054μg/ml) (p<0.005). Although serum level of β-carotene among cases (0.106±0.159 μg/ml) were lower compared to controls (0.134±0.131μg/ml), statistical significance was not observed. Logistic regression analysis showed that high serum level of retinol (OR=0.501, 95% CI=0.254-0.992, p<0.05) and α-tocopherol (OR=0.184, 95% CI=0.091-0.370, p<0.05) was significantly related to lower risk of oral cancer, whereas no relationship was observed between β-carotene and oral cancer risk. High serum levels of retinol and α-tocopherol confer protection against oral cancer risk.

  2. Tides and lake-level variations in the great Patagonian lakes: Observations, modelling and geophysical implications.

    NASA Astrophysics Data System (ADS)

    Marderwald, Eric; Richter, Andreas; Horwath, Martin; Hormaechea, Jose Luis; Groh, Andreas

    2016-04-01

    time series from Lagos Argentino and Viedma yields the amplitudes and phases of the lake tides for the four major tidal constituents M2, S2, O1 and K1. The maximum amplitude, corresponding to the semi-diurnal moon tide M2 in Lago Argentino, amounts to 3 mm. For the four lakes under investigation the theoretical amplitudes and phases of seven constituents (Q1, O1, P1, K1, N2, M2 and S2) are modelled accounting for the contributions of both the solid earth's body tides and the ocean tidal loading (Marderwald 2014). Both contributions involve a deformation of the earth surface and of the equipotential surfaces of the gravity field. For the load tide computation the global ocean tide model EOT11a (Savcenko and Bosch, 2012) and the Gutenberg-Bullen A earth model (Farrell, 1972) was applied and the conservation of water volume is taken into account. The comparison of the tidal signal extracted from the lake-level observations in Lagos Argentino and Viedma with the lake tide models indicates a phase shift which is most likely explained by an 1 hour phase lag of the employed global ocean tide model in the region of the highly fragmented Pacific coast. REFERENCES: Farrell, W. E., (1972). Deformation of the Earth by Surface Loads. Rev. Geophy. Space Phy., 10(3):761-797. Ivins, E., James, T., 2004. Bedrock response to Llanquihue Holocene and present-day glaciation in southernmost South America. Geophys. Res. Lett. 31 (L24613). Doi:10.1029/2004GL021500. Klemann, V., E. R. Ivins, Z. Martinec, and D. Wolf (2007), Models of active glacial isostasy roofing warm subduction: Case of the South Patagonian Ice Field, J. Geophys. Res., 112, B09405, doi: 10.1029/2006JB004818. Lange, H., Casassa, G., Ivins, E. R., Schröder, L., Fritsche, M., Richter, A., Groh, A., Dietrich, R., (2014). Observed crustal uplift near the Southern Patagonian Icefield constrains improved viscoelastic Earth models. Geophysical Research Letters, DOI: 10.1002/2013GL058419. Marderwald ER, 2014. Modelado de las mareas

  3. High level cognitive information processing in neural networks

    NASA Technical Reports Server (NTRS)

    Barnden, John A.; Fields, Christopher A.

    1992-01-01

    Two related research efforts were addressed: (1) high-level connectionist cognitive modeling; and (2) local neural circuit modeling. The goals of the first effort were to develop connectionist models of high-level cognitive processes such as problem solving or natural language understanding, and to understand the computational requirements of such models. The goals of the second effort were to develop biologically-realistic model of local neural circuits, and to understand the computational behavior of such models. In keeping with the nature of NASA's Innovative Research Program, all the work conducted under the grant was highly innovative. For instance, the following ideas, all summarized, are contributions to the study of connectionist/neural networks: (1) the temporal-winner-take-all, relative-position encoding, and pattern-similarity association techniques; (2) the importation of logical combinators into connection; (3) the use of analogy-based reasoning as a bridge across the gap between the traditional symbolic paradigm and the connectionist paradigm; and (4) the application of connectionism to the domain of belief representation/reasoning. The work on local neural circuit modeling also departs significantly from the work of related researchers. In particular, its concentration on low-level neural phenomena that could support high-level cognitive processing is unusual within the area of biological local circuit modeling, and also serves to expand the horizons of the artificial neural net field.

  4. A Terrestrial Reference Frame realised on the observation level using a GPS-LEO satellite constellation

    NASA Astrophysics Data System (ADS)

    Koenig, Daniel

    2018-02-01

    Applying a one-step integrated process, i.e. by simultaneously processing all data and determining all satellite orbits involved, a Terrestrial Reference Frame (TRF) consisting of a geometric as well as a dynamic part has been determined at the observation level using the EPOS-OC software of Deutsches GeoForschungsZentrum. The satellite systems involved comprise the Global Positioning System (GPS) as well as the twin GRACE spacecrafts. Applying a novel approach, the inherent datum defect has been overcome empirically. In order not to rely on theoretical assumptions this is done by carrying out the TRF estimation based on simulated observations and using the associated satellite orbits as background truth. The datum defect is identified here as the total of all three translations as well as the rotation about the z-axis of the ground station network leading to a rank-deficient estimation problem. To rectify this singularity, datum constraints comprising no-net translation (NNT) conditions in x, y, and z as well as a no-net rotation (NNR) condition about the z-axis are imposed. Thus minimally constrained, the TRF solution covers a time span of roughly a year with daily resolution. For the geometric part the focus is put on Helmert transformations between the a priori and the estimated sets of ground station positions, and the dynamic part is represented by gravity field coefficients of degree one and two. The results of a reference solution reveal the TRF parameters to be estimated reliably with high precision. Moreover, carrying out a comparable two-step approach using the same data and models leads to parameters and observational residuals of worse quality. A validation w.r.t. external sources shows the dynamic origin to coincide at a level of 5 mm or better in x and y, and mostly better than 15 mm in z. Comparing the derived GPS orbits to IGS final orbits as well as analysing the SLR residuals for the GRACE satellites reveals an orbit quality on the few cm level

  5. [Surveillance cultures after high-level disinfection of flexible endoscopes in a general hospital].

    PubMed

    Robles, Christian; Turín, Christie; Villar, Alicia; Huerta-Mercado, Jorge; Samalvides, Frine

    2014-04-01

    Flexible endoscopes are instruments with a complex structure which are used in invasive gastroenterological procedures, therefore high-level disinfection (HLD) is recommended as an appropriate reprocessing method. However, most hospitals do not perform a quality control to assess the compliance and results of the disinfection process. To evaluate the effectiveness of the flexible endoscopes’ decontamination after high-level disinfection by surveillance cultures and to assess the compliance with the reprocessing guidelines. Descriptive study conducted in January 2013 in the Gastroenterological Unit of a tertiary hospital. 30 endoscopic procedures were randomly selected. Compliance with guidelines was evaluated and surveillance cultures for common bacteria were performed after the disinfection process. On the observational assessment, compliance with the guidelines was as follows: pre-cleaning 9 (30%), cleaning 5 (16.7%), rinse 3 (10%), first drying 30 (100%), disinfection 30 (100%), final rinse 0 (0%) and final drying 30 (100%), demonstrating that only 3 of 7 stages of the disinfection process were optimally performed. In the microbiological evaluation, 2 (6.7%) of the 30 procedures had a positive culture obtained from the surface of the endoscope. Furthermore, 1 (4.2%) of the 24 biopsy forcepsgave a positive culture. The organisms isolated were different Pseudomonas species. High-level disinfection procedures were not optimally performed, finding in 6.7% positive cultures of Pseudomonas species.

  6. Correlation between high blood IL-6 level, hyperglycemia, and glucose control in septic patients.

    PubMed

    Nakamura, Masataka; Oda, Shigeto; Sadahiro, Tomohito; Watanabe, Eizo; Abe, Ryuzo; Nakada, Taka-Aki; Morita, Yasumasa; Hirasawa, Hiroyuki

    2012-12-12

    The aim of the present study was to investigate the relationship between the blood IL-6 level, the blood glucose level, and glucose control in septic patients. This retrospective observational study in a general ICU of a university hospital included a total of 153 patients with sepsis, severe sepsis, or septic shock who were admitted to the ICU between 2005 and 2010, stayed in the ICU for 7 days or longer, and did not receive steroid therapy prior to or after ICU admission. The severity of stress hyperglycemia, status of glucose control, and correlation between those two factors in these patients were investigated using the blood IL-6 level as an index of hypercytokinemia. A significant positive correlation between blood IL-6 level and blood glucose level on ICU admission was observed in the overall study population (n = 153; r = 0.24, P = 0.01), and was stronger in the nondiabetic subgroup (n = 112; r = 0.42, P < 0.01). The rate of successful glucose control (blood glucose level < 150 mg/dl maintained for 6 days or longer) decreased with increase in blood IL-6 level on ICU admission (P < 0.01). The blood IL-6 level after ICU admission remained significantly higher and the 60-day survival rate was significantly lower in the failed glucose control group than in the successful glucose control group (P < 0.01 and P < 0.01, respectively). High blood IL-6 level was correlated with hyperglycemia and with difficulties in glucose control in septic patients. These results suggest the possibility that hypercytokinemia might be involved in the development of hyperglycemia in sepsis, and thereby might affect the success of glucose control.

  7. High energy gamma-ray observations of SN 1987A

    NASA Technical Reports Server (NTRS)

    Sood, R. K.; Thomas, J. A.; Waldron, L.; Manchanda, R. K.; Rochester, G. K.

    1988-01-01

    Results are presented from observations of SN 1987A made with a combined high energy gamma ray and hard X-ray payload carried on a balloon flight over Alice Springs, Australia on April 5, 1988. The payload instrumentation is described, emphasizing the characteristics of the gamma-ray detector. The gamma-ray emission profile is illustrated and the preliminary results of the observations are summarized.

  8. Physical Activity Levels in Portuguese High School Physical Education

    ERIC Educational Resources Information Center

    Marmeleira, Jose Francisco Filipe; Aldeias, Nuno Micael Carrasqueira; da Graca, Pedro Miguel dos Santos Medeira

    2012-01-01

    The main aim of this study was to evaluate the physical activity (PA) levels of high school Portuguese students during physical education (PE) and investigate the association of PA levels with students' goal orientation and intrinsic motivation. Forty-six students from three high schools participated. Heart rate telemetry and pedometry were used…

  9. Lidar observations revealing transport of O3 in the presence of a nocturnal low-level jet: Regional implications for ;next-day; pollution

    NASA Astrophysics Data System (ADS)

    Sullivan, John T.; Rabenhorst, Scott D.; Dreessen, Joel; McGee, Thomas J.; Delgado, Ruben; Twigg, Laurence; Sumnicht, Grant

    2017-06-01

    Remotely sensed profiles of ozone (O3) and wind are presented continuously for the first time during a nocturnal low-level jet (NLLJ) event occurring after a severe O3 episode in the Baltimore-Washington D.C. (BW) urban corridor throughout 11-12 June 2015. High-resolution O3 lidar observations indicate a well-mixed and polluted daytime O3 reservoir, which decayed into a contaminated nocturnal residual layer (RL) with concentrations between 70 and 100 ppbv near 1 km above the surface. Observations indicate the onset of the NLLJ was responsible for transporting polluted O3 away from the region, while simultaneously affecting the height and location of the nocturnal residual layer. High-resolution modeling analyses and next-day (12 June) lidar, surface, and balloon-borne observations indicate the trajectory of the NLLJ and polluted residual layer corresponds with "next-day" high O3 at sites throughout the southern New England region (New York, Connecticut, Massachusetts). The novel O3 lidar observations are evidence of both nocturnal advection (via high NLLJ wind fields) and entrainment of the polluted residual layer in the presence of the "next-day" convectively growing boundary layer. In the greater context, the novel observational suite described in this work has shown that the chemical budget in areas downwind of major urban centers can be altered significantly overnight during transport events such as the NLLJ.

  10. High-latitude observations of solar wind streams and coronal holes

    NASA Technical Reports Server (NTRS)

    Ricket, B. J.; Sime, D. G.; Crockett, W. R.; Tousey, R.; Sheeley, N. R., Jr.

    1976-01-01

    Interplanetary scintillation observations of the solar wind velocity during 1973 and the first part of 1974 reveal several corotating high-speed streams. These streams, of heliographic latitudes from +40 deg to -60 deg, have been mapped back to the vicinity of the sun and have been compared with coronal holes identified in wide band XUV solar images taken during the manned portions of the Skylab mission. There is some evidence that the high-speed streams are preferentially associated with coronal holes and that they can spread out from the hole boundaries up to about 20 deg in latitude. However, this association is not one to one; streams are observed which do not map back to coronal holes, and holes are observed which do not lie at the base of streams. To the extent that a statistical interpretation is possible the association is not highly significant, but individual consideration of streams and holes suggests that the statistical result is biased somewhat against a strong correlation.

  11. An overview of very high level software design methods

    NASA Technical Reports Server (NTRS)

    Asdjodi, Maryam; Hooper, James W.

    1988-01-01

    Very High Level design methods emphasize automatic transfer of requirements to formal design specifications, and/or may concentrate on automatic transformation of formal design specifications that include some semantic information of the system into machine executable form. Very high level design methods range from general domain independent methods to approaches implementable for specific applications or domains. Applying AI techniques, abstract programming methods, domain heuristics, software engineering tools, library-based programming and other methods different approaches for higher level software design are being developed. Though one finds that a given approach does not always fall exactly in any specific class, this paper provides a classification for very high level design methods including examples for each class. These methods are analyzed and compared based on their basic approaches, strengths and feasibility for future expansion toward automatic development of software systems.

  12. Extending Automatic Parallelization to Optimize High-Level Abstractions for Multicore

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liao, C; Quinlan, D J; Willcock, J J

    2008-12-12

    Automatic introduction of OpenMP for sequential applications has attracted significant attention recently because of the proliferation of multicore processors and the simplicity of using OpenMP to express parallelism for shared-memory systems. However, most previous research has only focused on C and Fortran applications operating on primitive data types. C++ applications using high-level abstractions, such as STL containers and complex user-defined types, are largely ignored due to the lack of research compilers that are readily able to recognize high-level object-oriented abstractions and leverage their associated semantics. In this paper, we automatically parallelize C++ applications using ROSE, a multiple-language source-to-source compiler infrastructuremore » which preserves the high-level abstractions and gives us access to their semantics. Several representative parallelization candidate kernels are used to explore semantic-aware parallelization strategies for high-level abstractions, combined with extended compiler analyses. Those kernels include an array-base computation loop, a loop with task-level parallelism, and a domain-specific tree traversal. Our work extends the applicability of automatic parallelization to modern applications using high-level abstractions and exposes more opportunities to take advantage of multicore processors.« less

  13. First results from the Goddard High-Resolution spectrograph - High-resolution observations of the 1942 A resonance line of HG II in the chemically peculiar B star, Chi Lupi

    NASA Technical Reports Server (NTRS)

    Leckrone, David S.; Wahlgren, Glenn M.; Johansson, Sveneric G.

    1991-01-01

    The Goddard High-Resolution Spectrograph on the HST has been used to obtain high S/N observations of the sharp-lined, Hg- and Pt-rich B-type star, Chi Lupi, with a resolving power of 87,000. The observations reveal a level of spectroscopic detail never before observed at ultraviolet wavelengths for any star other than the sun. Concentrating on the region around the resonance line of Hg II at 1942 A, the profile and central position of this line confirm beyond doubt that the Hg isotope anomaly in Chi Lupi is real and extreme, with Hg being heavily concentrated in the form of Hg-204. The problems in atomic physics which impair the accurate analysis of spectra of this quality are emphasized.

  14. Robustness of observation-based decadal sea level variability in the Indo-Pacific Ocean

    NASA Astrophysics Data System (ADS)

    Nidheesh, A. G.; Lengaigne, M.; Vialard, J.; Izumo, T.; Unnikrishnan, A. S.; Meyssignac, B.; Hamlington, B.; de Boyer Montegut, C.

    2017-07-01

    We examine the consistency of Indo-Pacific decadal sea level variability in 10 gridded, observation-based sea level products for the 1960-2010 period. Decadal sea level variations are robust in the Pacific, with more than 50% of variance explained by decadal modulation of two flavors of El Niño-Southern Oscillation (classical ENSO and Modoki). Amplitude of decadal sea level variability is weaker in the Indian Ocean than in the Pacific. All data sets indicate a transmission of decadal sea level signals from the western Pacific to the northwest Australian coast through the Indonesian throughflow. The southern tropical Indian Ocean sea level variability is associated with decadal modulations of ENSO in reconstructions but not in reanalyses or in situ data set. The Pacific-independent Indian Ocean decadal sea level variability is not robust but tends to be maximum in the southwestern tropical Indian Ocean. The inconsistency of Indian Ocean decadal variability across the sea level products calls for caution in making definitive conclusions on decadal sea level variability in this basin.

  15. Earth observations during Space Shuttle flight STS-27: A high latitude observations opportunity - 2-6 December 1988

    NASA Technical Reports Server (NTRS)

    Whitehead, Victor S.; Helfert, Michael R.; Lulla, Kamlesh P.; Wood, Charles A.; Amsbury, David L.; Gibson, Robert; Gardner, Guy; Mullane, Mike; Ross, Jerry; Shepherd, Bill

    1989-01-01

    The earth observations from the STS-27 mission on December 2-6, 1988 are reported. The film and generic scene characteristics chosen for the mission are given. Results are given from geological observations of the Ruwenzori Mountains between Uganda and Zaire, four rift valley systems in Africa and Asia, and several volcanoes and impact craters. Environmental observations of Africa, the Middle East, South Asia, North America and the Soviet Union, are presented. Also, meteorological and oceanographic observations are discussed. The uniqueness of the high-inclination winter launch of the STS-27 mission for obtaining observations of specific features is noted.

  16. Observations and estimates of wave-driven water level extremes at the Marshall Islands

    NASA Astrophysics Data System (ADS)

    Merrifield, M. A.; Becker, J. M.; Ford, M.; Yao, Y.

    2014-10-01

    Wave-driven extreme water levels are examined for coastlines protected by fringing reefs using field observations obtained in the Republic of the Marshall Islands. The 2% exceedence water level near the shoreline due to waves is estimated empirically for the study sites from breaking wave height at the outer reef and by combining separate contributions from setup, sea and swell, and infragravity waves, which are estimated based on breaking wave height and water level over the reef flat. Although each component exhibits a tidal dependence, they sum to yield a 2% exceedence level that does not. A hindcast based on the breaking wave height parameterization is used to assess factors leading to flooding at Roi-Namur caused by an energetic swell event during December 2008. Extreme water levels similar to December 2008 are projected to increase significantly with rising sea level as more wave and tide events combine to exceed inundation threshold levels.

  17. The HSP terminator of Arabidopsis thaliana induces a high level of miraculin accumulation in transgenic tomatoes.

    PubMed

    Hirai, Tadayoshi; Kurokawa, Natsuko; Duhita, Narendra; Hiwasa-Tanase, Kyoko; Kato, Kazuhisa; Kato, Ko; Ezura, Hiroshi

    2011-09-28

    High-level accumulation of the target recombinant protein is a significant issue in heterologous protein expression using transgenic plants. Miraculin, a taste-modifying protein, was accumulated in transgenic tomatoes using an expression cassette in which the miraculin gene was expressed by the cauliflower mosaic virus (CaMV) 35S promoter and the heat shock protein (HSP) terminator (MIR-HSP). The HSP terminator was derived from heat shock protein 18.2 in Arabidopsis thaliana . Using this HSP-containing cassette, the miraculin concentration in T0 transgenic tomato lines was 1.4-13.9% of the total soluble protein (TSP), and that in the T1 transgenic tomato line homozygous for the miraculin gene reached 17.1% of the TSP. The accumulation level of the target protein was comparable to levels observed with chloroplast transformation. The high-level accumulation of miraculin in T0 transgenic tomato lines achieved by the HSP terminator was maintained in the successive T1 generation, demonstrating the genetic stability of this accumulation system.

  18. Observation of Landau levels in potassium-intercalated graphite under a zero magnetic field

    PubMed Central

    Guo, Donghui; Kondo, Takahiro; Machida, Takahiro; Iwatake, Keigo; Okada, Susumu; Nakamura, Junji

    2012-01-01

    The charge carriers in graphene are massless Dirac fermions and exhibit a relativistic Landau-level quantization in a magnetic field. Recently, it has been reported that, without any external magnetic field, quantized energy levels have been also observed from strained graphene nanobubbles on a platinum surface, which were attributed to the Landau levels of massless Dirac fermions in graphene formed by a strain-induced pseudomagnetic field. Here we show the generation of the Landau levels of massless Dirac fermions on a partially potassium-intercalated graphite surface without applying external magnetic field. Landau levels of massless Dirac fermions indicate the graphene character in partially potassium-intercalated graphite. The generation of the Landau levels is ascribed to a vector potential induced by the perturbation of nearest-neighbour hopping, which may originate from a strain or a gradient of on-site potentials at the perimeters of potassium-free domains. PMID:22990864

  19. Influence of the observer's level of experience on systolic and diastolic arterial blood pressure measurements using Doppler ultrasonography in healthy conscious cats.

    PubMed

    Gouni, Vassiliki; Tissier, Renaud; Misbach, Charlotte; Balouka, David; Bueno, Hanna; Pouchelon, Jean-Louis; Lefebvre, Hervé P; Chetboul, Valérie

    2015-02-01

    The objective of this study was to determine the influence of the observer's level of experience on within- and between-day variability, and the percentage of successful systolic (SAP) and diastolic arterial blood pressure (DAP) measurements obtained by Doppler ultrasonography (DU) in awake cats. For this purpose, six healthy conscious cats were used and four observers with different levels of training performed 144 SAP and DAP measurements on 4 days using DU. Measurements were recorded five consecutive times, and mean values were used for statistical analysis. Only the two most skilled observers - a PhD student in cardiology and a Dipl ECVIM-CA (cardiology) - had within- and between-day coefficients of variation (CVs) for SAP ⩽16% (13-16%). Conversely, the two less experienced observers - a fifth-year student and an assistant - had high between-day CVs (61% and 73%). For DAP, only the most experienced observer (Dipl ECVIM-CA) succeeded in 100% of the attempts, with within- and between-day CVs of 11% and 4%, respectively. Conversely, DAP could not be measured by the other three observers in 8%, 19% and 56% of attempts (from the highest to the lowest level of experience); therefore, the corresponding CV values could not be calculated. In conclusion, SAP may be assessed using DU in healthy awake cats with good repeatability and reproducibility by a well-trained observer. Measurement of DAP is more difficult than of SAP, and needs a longer training period, which represents one of the limitations of DU in cats. © ISFM and AAFP 2014.

  20. Signal and noise level estimation for narrow spectral width returns observed by the Indian MST radar

    NASA Astrophysics Data System (ADS)

    Hooper, D. A.

    1999-07-01

    Use is made of five sets of multibeam observations of the lower atmosphere made by the Indian mesosphere-stratosphere-troposphere (MST) radar. Two aspects of signal processing which can lead to serious underestimates of the signal-to-noise ratio are considered. First, a comparison is made of the effects of different data weighting windows applied to the inphase and quadrature components of the radar return samples prior to Fourier transformation. The relatively high degree of spectral leakage associated with the rectangular and Hamming windows can give rise to overestimates of the noise levels by up to 28 dB for the strongest signals. Use of the Hanning window is found to be the most appropriate for these particular data. Second, a technique for removing systematic dc biases from the data in the time domain is compared with the more well-known practice of correction in the frequency domain. The latter technique, which is often used to remove the effects of ground clutter, is shown to be particularly inappropriate for the characteristically narrow spectral width signals observed by the Indian MST radar. For cases of near-zero Doppler shift it can remove up to 30 dB of signal information. The consequences of noise and signal level discrepancies for studies of refractivity structures are discussed. It is shown that neither problem has a significant effect on Doppler shift or spectral width estimates.

  1. Statistics of high-level scene context

    PubMed Central

    Greene, Michelle R.

    2013-01-01

    Context is critical for recognizing environments and for searching for objects within them: contextual associations have been shown to modulate reaction time and object recognition accuracy, as well as influence the distribution of eye movements and patterns of brain activations. However, we have not yet systematically quantified the relationships between objects and their scene environments. Here I seek to fill this gap by providing descriptive statistics of object-scene relationships. A total of 48, 167 objects were hand-labeled in 3499 scenes using the LabelMe tool (Russell et al., 2008). From these data, I computed a variety of descriptive statistics at three different levels of analysis: the ensemble statistics that describe the density and spatial distribution of unnamed “things” in the scene; the bag of words level where scenes are described by the list of objects contained within them; and the structural level where the spatial distribution and relationships between the objects are measured. The utility of each level of description for scene categorization was assessed through the use of linear classifiers, and the plausibility of each level for modeling human scene categorization is discussed. Of the three levels, ensemble statistics were found to be the most informative (per feature), and also best explained human patterns of categorization errors. Although a bag of words classifier had similar performance to human observers, it had a markedly different pattern of errors. However, certain objects are more useful than others, and ceiling classification performance could be achieved using only the 64 most informative objects. As object location tends not to vary as a function of category, structural information provided little additional information. Additionally, these data provide valuable information on natural scene redundancy that can be exploited for machine vision, and can help the visual cognition community to design experiments guided by

  2. Statistics of high-level scene context.

    PubMed

    Greene, Michelle R

    2013-01-01

    CONTEXT IS CRITICAL FOR RECOGNIZING ENVIRONMENTS AND FOR SEARCHING FOR OBJECTS WITHIN THEM: contextual associations have been shown to modulate reaction time and object recognition accuracy, as well as influence the distribution of eye movements and patterns of brain activations. However, we have not yet systematically quantified the relationships between objects and their scene environments. Here I seek to fill this gap by providing descriptive statistics of object-scene relationships. A total of 48, 167 objects were hand-labeled in 3499 scenes using the LabelMe tool (Russell et al., 2008). From these data, I computed a variety of descriptive statistics at three different levels of analysis: the ensemble statistics that describe the density and spatial distribution of unnamed "things" in the scene; the bag of words level where scenes are described by the list of objects contained within them; and the structural level where the spatial distribution and relationships between the objects are measured. The utility of each level of description for scene categorization was assessed through the use of linear classifiers, and the plausibility of each level for modeling human scene categorization is discussed. Of the three levels, ensemble statistics were found to be the most informative (per feature), and also best explained human patterns of categorization errors. Although a bag of words classifier had similar performance to human observers, it had a markedly different pattern of errors. However, certain objects are more useful than others, and ceiling classification performance could be achieved using only the 64 most informative objects. As object location tends not to vary as a function of category, structural information provided little additional information. Additionally, these data provide valuable information on natural scene redundancy that can be exploited for machine vision, and can help the visual cognition community to design experiments guided by statistics

  3. High inter-observer agreement of observer-perceived pain assessment in the emergency department.

    PubMed

    Hangaard, Martin Høhrmann; Malling, Brian; Mogensen, Christian Backer

    2018-02-21

    Triage is used to prioritize the patients in the emergency department. The majority of the triage systems include the patients' pain score to assess their level of acuity by using a combination of patient reported pain and observer-perceived pain; the latter therefore requires a certain degree of inter-observer agreement. The aim of the present study was to assess the inter-observer agreement of perceived pain among emergency department nurses and to evaluate if it was influenced by predetermined factors like age and gender. A project assistant randomly recruited two nurses, who were not allowed to interact with each other, to assess patient pain intensity on the numeric ranking scale. The project assistant afterwards entered the pain scores in a predesigned electronic questionnaire. We used weighted Fleiss-Cohen (quadratic) kappa statistics, Bland-Altman statistics and logistic regression analysis to assess the inter-observer agreement. One hundred and sixty-two patients were included. They had a median age of 38 years and 45% were females. 30% of the patients were acute surgical patients and 70% acute orthopedic patients. The average time between the pain assessments were 1,7 min. The Bland Altman analysis found a mean difference in pain score of 0.2 and 95% limits of agreement of +/- 3 point. When the NRS scores were translated to commonly used pain categories (no, mild, moderate or severe pain) we found a 70% agreement with a mean difference in categories of 0.05 and 95% limits of agreement of +/- 1 category. Patient age, gender, localization of pain, examination room or presence of a significant other did not affect the inter-observer agreement. We found 70% agreement on pain category between the nurses and it is justified that nurse-perceived pain assessment is used for triage in the emergency department.

  4. CNES developments of key detection technologies to prepare next generation focal planes for high resolution Earth observation

    NASA Astrophysics Data System (ADS)

    Materne, A.; Virmontois, C.; Bardoux, A.; Gimenez, T.; Biffi, J. M.; Laubier, D.; Delvit, J. M.

    2014-10-01

    This paper describes the activities managed by CNES (French National Space Agency) for the development of focal planes for next generation of optical high resolution Earth observation satellites, in low sun-synchronous orbit. CNES has launched a new programme named OTOS, to increase the level of readiness (TRL) of several key technologies for high resolution Earth observation satellites. The OTOS programme includes several actions in the field of detection and focal planes: a new generation of CCD and CMOS image sensors, updated analog front-end electronics and analog-to-digital converters. The main features that must be achieved on focal planes for high resolution Earth Observation, are: readout speed, signal to noise ratio at low light level, anti-blooming efficiency, geometric stability, MTF and line of sight stability. The next steps targeted are presented in comparison to the in-flight measured performance of the PLEIADES satellites launched in 2011 and 2012. The high resolution panchromatic channel is still based upon Backside illuminated (BSI) CCDs operated in Time Delay Integration (TDI). For the multispectral channel, the main evolution consists in moving to TDI mode and the competition is open with the concurrent development of a CCD solution versus a CMOS solution. New CCDs will be based upon several process blocks under evaluation on the e2v 6 inches BSI wafer manufacturing line. The OTOS strategy for CMOS image sensors investigates on one hand custom TDI solutions within a similar approach to CCDs, and, on the other hand, investigates ways to take advantage of existing performance of off-the-shelf 2D arrays CMOS image sensors. We present the characterization results obtained from test vehicles designed for custom TDI operation on several CIS technologies and results obtained before and after radiation on snapshot 2D arrays from the CMOSIS CMV family.

  5. Real-time sea-level gauge observations and operational oceanography.

    PubMed

    Mourre, Baptiste; Crosnier, Laurence; Provost, Christian Le

    2006-04-15

    The contribution of tide-gauge data, which provide a unique monitoring of sea-level variability along the coasts of the world ocean, to operational oceanography is discussed in this paper. Two distinct applications that both demonstrate tide-gauge data utility when delivered in real-time are illustrated. The first case details basin-scale operational model validation of the French Mercator operational system applied to the North Atlantic. The accuracy of model outputs in the South Atlantic Bight both at coastal and offshore locations is evaluated using tide-gauge observations. These data enable one to assess the model's nowcasts and forecasts reliability which is needed in order for the model boundary conditions to be delivered to other coastal prediction systems. Such real-time validation is possible as long as data are delivered within a delay of a week. In the second application, tide-gauge data are assimilated in a storm surge model of the North Sea and used to control model trajectories in real-time. Using an advanced assimilation scheme that takes into account the swift evolution of model error statistics, these observations are shown to be very efficient to control model error, provided that they can be assimilated very frequently (i.e. available within a few hours).

  6. Evidence for dawsonite in Hanford high-level nuclear waste tanks.

    PubMed

    Reynolds, Jacob G; Cooke, Gary A; Herting, Daniel L; Warrant, R Wade

    2012-03-30

    Gibbsite [Al(OH)(3)] and boehmite (AlOOH) have long been assumed to be the most prevalent aluminum-bearing minerals in Hanford high-level nuclear waste sludge. The present study shows that dawsonite [NaAl(OH)(2)CO(3)] is also a common aluminum-bearing phase in tanks containing high total inorganic carbon (TIC) concentrations and (relatively) low dissolved free hydroxide concentrations. Tank samples were probed for dawsonite by X-ray Diffraction (XRD), Scanning Electron Microscopy with Energy Dispersive Spectrometry (SEM-EDS) and Polarized Light Optical Microscopy. Dawsonite was conclusively identified in four of six tanks studied. In a fifth tank (AN-102), the dawsonite identification was less conclusive because it was only observed as a Na-Al bearing phase with SEM-EDS. Four of the five tank samples with dawsonite also had solid phase Na(2)CO(3) · H(2)O. The one tank without observable dawsonite (Tank C-103) had the lowest TIC content of any of the six tanks. The amount of TIC in Tank C-103 was insufficient to convert most of the aluminum to dawsonite (Al:TIC mol ratio of 20:1). The rest of the tank samples had much lower Al:TIC ratios (between 2:1 and 0.5:1) than Tank C-103. One tank (AZ-102) initially had dawsonite, but dawsonite was not observed in samples taken 15 months after NaOH was added to the tank surface. When NaOH was added to a laboratory sample of waste from Tank AZ-102, the ratio of aluminum to TIC in solution was consistent with the dissolution of dawsonite. The presence of dawsonite in these tanks is of significance because of the large amount of OH(-) consumed by dawsonite dissolution, an effect confirmed with AZ-102 samples. Copyright © 2012 Elsevier B.V. All rights reserved.

  7. Python based high-level synthesis compiler

    NASA Astrophysics Data System (ADS)

    Cieszewski, Radosław; Pozniak, Krzysztof; Romaniuk, Ryszard

    2014-11-01

    This paper presents a python based High-Level synthesis (HLS) compiler. The compiler interprets an algorithmic description of a desired behavior written in Python and map it to VHDL. FPGA combines many benefits of both software and ASIC implementations. Like software, the mapped circuit is flexible, and can be reconfigured over the lifetime of the system. FPGAs therefore have the potential to achieve far greater performance than software as a result of bypassing the fetch-decode-execute operations of traditional processors, and possibly exploiting a greater level of parallelism. Creating parallel programs implemented in FPGAs is not trivial. This article describes design, implementation and first results of created Python based compiler.

  8. Aeon: Synthesizing Scheduling Algorithms from High-Level Models

    NASA Astrophysics Data System (ADS)

    Monette, Jean-Noël; Deville, Yves; van Hentenryck, Pascal

    This paper describes the aeon system whose aim is to synthesize scheduling algorithms from high-level models. A eon, which is entirely written in comet, receives as input a high-level model for a scheduling application which is then analyzed to generate a dedicated scheduling algorithm exploiting the structure of the model. A eon provides a variety of synthesizers for generating complete or heuristic algorithms. Moreover, synthesizers are compositional, making it possible to generate complex hybrid algorithms naturally. Preliminary experimental results indicate that this approach may be competitive with state-of-the-art search algorithms.

  9. Highly resolved fluid flows: "liquid plasmas" at the kinetic level.

    PubMed

    Morfill, Gregor E; Rubin-Zuzic, Milenko; Rothermel, Hermann; Ivlev, Alexei V; Klumov, Boris A; Thomas, Hubertus M; Konopka, Uwe; Steinberg, Victor

    2004-04-30

    Fluid flow around an obstacle was observed at the kinetic (individual particle) level using "complex (dusty) plasmas" in their liquid state. These "liquid plasmas" have bulk properties similar to water (e.g., viscosity), and a comparison in terms of similarity parameters suggests that they can provide a unique tool to model classical fluids. This allows us to study "nanofluidics" at the most elementary-the particle-level, including the transition from fluid behavior to purely kinetic transport. In this (first) experimental investigation we describe the kinetic flow topology, discuss our observations in terms of fluid theories, and follow this up with numerical simulations.

  10. Assessing the sources of high fecal coliform levels at an urban tropical beach

    PubMed Central

    Davino, Aline Mendonça Cavalcante; de Melo, Milena Bandeira; Caffaro, Roberto Augusto

    2015-01-01

    Recreational water quality is commonly assessed by microbial indicators such as fecal coliforms. Maceió is the capital of Alagoas state, located in tropical northeastern Brazil. Its beaches are considered as the most beautiful urban beaches in the country. Jatiúca Beach in Maceió was found to be unsuitable for bathing continuously during the year of 2011. The same level of contamination was not observed in surrounding beaches. The aim of this study was to initiate the search for the sources of these high coliform levels, so that contamination can be eventually mitigated. We performed a retrospective analysis of historical results of fecal coliform concentrations from 2006 to 2012 at five monitoring stations located in the study region. Results showed that Jatiúca Beach consistently presented the worst quality among the studied beaches. A field survey was conducted to identify existing point and non-point sources of pollution in the area. Monitoring in the vicinity of Jatiúca was spatially intensified. Fecal coliform concentrations were categorized according to tide range and tide stage. A storm drain located in northern Jatiúca was identified as the main point source of the contamination. However, fecal coliform concentrations at Jatiúca were high during high tides and spring tides even when this point source was inactive (no rainfall). We hypothesize that high fecal coliform levels in Jatiúca Beach may also be caused by aquifer contamination or, more likely, from tide washing of contaminated sand. Both of these hypotheses will be further investigated. PMID:26691459

  11. Assessing the sources of high fecal coliform levels at an urban tropical beach.

    PubMed

    Davino, Aline Mendonça Cavalcante; de Melo, Milena Bandeira; Caffaro Filho, Roberto Augusto

    2015-01-01

    Recreational water quality is commonly assessed by microbial indicators such as fecal coliforms. Maceió is the capital of Alagoas state, located in tropical northeastern Brazil. Its beaches are considered as the most beautiful urban beaches in the country. Jatiúca Beach in Maceió was found to be unsuitable for bathing continuously during the year of 2011. The same level of contamination was not observed in surrounding beaches. The aim of this study was to initiate the search for the sources of these high coliform levels, so that contamination can be eventually mitigated. We performed a retrospective analysis of historical results of fecal coliform concentrations from 2006 to 2012 at five monitoring stations located in the study region. Results showed that Jatiúca Beach consistently presented the worst quality among the studied beaches. A field survey was conducted to identify existing point and non-point sources of pollution in the area. Monitoring in the vicinity of Jatiúca was spatially intensified. Fecal coliform concentrations were categorized according to tide range and tide stage. A storm drain located in northern Jatiúca was identified as the main point source of the contamination. However, fecal coliform concentrations at Jatiúca were high during high tides and spring tides even when this point source was inactive (no rainfall). We hypothesize that high fecal coliform levels in Jatiúca Beach may also be caused by aquifer contamination or, more likely, from tide washing of contaminated sand. Both of these hypotheses will be further investigated.

  12. High accuracy electronic material level sensor

    DOEpatents

    McEwan, T.E.

    1997-03-11

    The High Accuracy Electronic Material Level Sensor (electronic dipstick) is a sensor based on time domain reflectometry (TDR) of very short electrical pulses. Pulses are propagated along a transmission line or guide wire that is partially immersed in the material being measured; a launcher plate is positioned at the beginning of the guide wire. Reflected pulses are produced at the material interface due to the change in dielectric constant. The time difference of the reflections at the launcher plate and at the material interface are used to determine the material level. Improved performance is obtained by the incorporation of: (1) a high accuracy time base that is referenced to a quartz crystal, (2) an ultrawideband directional sampler to allow operation without an interconnect cable between the electronics module and the guide wire, (3) constant fraction discriminators (CFDs) that allow accurate measurements regardless of material dielectric constants, and reduce or eliminate errors induced by triple-transit or ``ghost`` reflections on the interconnect cable. These improvements make the dipstick accurate to better than 0.1%. 4 figs.

  13. High accuracy electronic material level sensor

    DOEpatents

    McEwan, Thomas E.

    1997-01-01

    The High Accuracy Electronic Material Level Sensor (electronic dipstick) is a sensor based on time domain reflectometry (TDR) of very short electrical pulses. Pulses are propagated along a transmission line or guide wire that is partially immersed in the material being measured; a launcher plate is positioned at the beginning of the guide wire. Reflected pulses are produced at the material interface due to the change in dielectric constant. The time difference of the reflections at the launcher plate and at the material interface are used to determine the material level. Improved performance is obtained by the incorporation of: 1) a high accuracy time base that is referenced to a quartz crystal, 2) an ultrawideband directional sampler to allow operation without an interconnect cable between the electronics module and the guide wire, 3) constant fraction discriminators (CFDs) that allow accurate measurements regardless of material dielectric constants, and reduce or eliminate errors induced by triple-transit or "ghost" reflections on the interconnect cable. These improvements make the dipstick accurate to better than 0.1%.

  14. Assimilation of Smos Observations to Generate a Prototype SMAP Level 4 Surface and Root-Zone Soil Moisture Product

    NASA Technical Reports Server (NTRS)

    Reichle, Rolf H.; De Lannoy, Gabrielle J. M.; Crow, Wade T.; Koster, Randal D.; Kimball, John

    2012-01-01

    The Soil Moisture Active and Passive (SMAP; [1]) mission is being implemented by NASA for launch in October 2014. The primary science objectives of SMAP are to enhance understanding of land surface controls on the water, energy and carbon cycles, and to determine their linkages. Moreover, the high-resolution soil moisture mapping provided by SMAP has practical applications in weather and seasonal climate prediction, agriculture, human health, drought and flood decision support. The Soil Moisture and Ocean Salinity (SMOS; [2]) mission was launched by ESA in November 2009 and has since been observing L-band (1.4 GHz) upwelling passive microwaves. In this paper we describe our use of SMOS brightness temperature observations to generate a prototype of the planned SMAP Level 4 Surface and Root-zone Soil Moisture (L4_SM) product [5].

  15. Relationship Between Serum Zinc Level and Metabolic Syndrome: A Meta-Analysis of Observational Studies.

    PubMed

    Zhang, Yi; Zhang, Dian-Zhong

    2018-05-10

    This research sought to summarize the evidence regarding the relationship between serum zinc level and metabolic syndrome (MetS). The electronic databases of PubMed, Web of Science, and Embase were searched up to October 2017 for observational studies on the association between serum zinc level and MetS. The standard mean difference (SMD) and its corresponding 95% confidence interval (CI) of the serum zinc level for MetS versus control participants were calculated. In addition, the pooled odds ratio (OR) and relative risk (RR) of MetS for the highest versus lowest category of serum zinc level, as well as their corresponding 95% CI, were also calculated. A total of 11 observational studies (8 cross-sectional, 1 case-control, and 2 cohort studies) were included in this meta-analysis. The combined SMD demonstrated that the serum zinc level in MetS was higher than that in control participants (SMD = 0.11; 95% CI, 0.03-0.19; p = 0.009). Moreover, the overall multivariable-adjusted RR showed that the increased serum zinc level was associated with a higher risk of MetS (RR = 1.82; 95% CI, 1.33-2.50; p < 0.001). On the contrary, the overall multivariable-adjusted OR showed that there was no significant relationship between serum zinc level and MetS (OR = 1.00; 95% CI, 0.99-1.01; p = 0.841). Although the serum zinc level in participants with MetS was significantly higher than that in control ones, the existing evidence was still insufficient to conclude a definite relationship between serum zinc level and MetS. More well-designed prospective cohort studies are needed to elaborate the concerned issues further.

  16. Evidence for -Gz Adaptation Observed with Wearable Biosensors During High Performance Jet Flight.

    PubMed

    Rice, G Merrill; Snider, Dallas; Moore, Jeffrey L; Lavan, J Timothy; Folga, Rich; VanBrunt, Thomas B

    2016-12-01

    Few studies have evaluated physiological responses to high acceleration forces during actual flight and to our knowledge no normative data has been acquired by technologies such as wearable biosensors during high performance jet aircraft operations. In-flight physiological data from an FDA cleared portable triaxial accelerometer and bio-sensor were observed from five active duty F-18 pilots of the Naval Flight Demonstration Squadron (Blue Angels). Of the five pilots, three were formation pilots who flew lower G profiles and two were solo pilots who flew higher G profiles. Physiological parameters monitored were heart rate, respiratory rate, temperature, caloric expenditure, and duration of exposure to levels of acceleration. Evaluated were 25 practice demonstration flights; 9 flights were excluded secondary to incomplete or inaccurate physiological data. We observed no significant bradycardia during a total of 189 maneuvers which met inclusion criteria for push-pull events (PPE) or isolated -Gz exposures. Further analysis of 73 PPE revealed an overall significant rise in HR following the PPE, where mean heart rate was 106 (95% CI, 100:112) at the beginning of the push and 129 (95% CI, 123:135) following the pull. A majority of the flights monitored provided reliable physiological data. Initial data suggests, contrary to currently held aeromedical doctrine, maneuvers such as the "push-pull" do not evoke vasovagal based bradycardic responses in aerobatic pilots. Possible explanations for these findings are sympathetic nervous system activation through adaptation and/or sustained isometric resistance from control inputs, both of which are areas of future research for our team.Rice GM, Snider D, Moore JL, Lavan JT, Folga R, VanBrunt TB. Evidence for -Gz adaptation observed with wearable biosensors during high performance jet flight. Aerosp Med Hum Perform. 2016; 87(12):996-1003.

  17. The High Level Data Reduction Library

    NASA Astrophysics Data System (ADS)

    Ballester, P.; Gabasch, A.; Jung, Y.; Modigliani, A.; Taylor, J.; Coccato, L.; Freudling, W.; Neeser, M.; Marchetti, E.

    2015-09-01

    The European Southern Observatory (ESO) provides pipelines to reduce data for most of the instruments at its Very Large telescope (VLT). These pipelines are written as part of the development of VLT instruments, and are used both in the ESO's operational environment and by science users who receive VLT data. All the pipelines are highly specific geared toward instruments. However, experience showed that the independently developed pipelines include significant overlap, duplication and slight variations of similar algorithms. In order to reduce the cost of development, verification and maintenance of ESO pipelines, and at the same time improve the scientific quality of pipelines data products, ESO decided to develop a limited set of versatile high-level scientific functions that are to be used in all future pipelines. The routines are provided by the High-level Data Reduction Library (HDRL). To reach this goal, we first compare several candidate algorithms and verify them during a prototype phase using data sets from several instruments. Once the best algorithm and error model have been chosen, we start a design and implementation phase. The coding of HDRL is done in plain C and using the Common Pipeline Library (CPL) functionality. HDRL adopts consistent function naming conventions and a well defined API to minimise future maintenance costs, implements error propagation, uses pixel quality information, employs OpenMP to take advantage of multi-core processors, and is verified with extensive unit and regression tests. This poster describes the status of the project and the lesson learned during the development of reusable code implementing algorithms of high scientific quality.

  18. Methemoglobin reduction in crocodile blood: are high levels of MetHb typical of healthy reptiles?

    PubMed

    Gruca, M; Grigg, G C

    1980-08-01

    In 82 wild-caught Crocodylus porosus, levels of NADH-MetHb reductase and GSH seem adequate to maintain hemoglobin in its reduced functional state. Studies of C. porosus erythrocytes in vitro show reduction of metHb in the presence of lactate, glucose and plasma, but not pyruvate. These findings, together with recent data which show low metHb in a variety of reptiles, cast doubt on the accepted view that high levels of MetHb are typical of healthy reptiles. One explanation for the sharp contrast between earlier and more recent data could be technical. We found low metHb in Crocodylus johnstoni, Chelodina longicollis and Sphenomorphus quoyi. However, high and variable vales reminiscent of many of the earlier data were obtained by omitting final centrifugation prior to spectrophotometry. Interestingly, this step is not part of the standard clinical method but is necessary in analyses of blood with nucleated red cells. These observations suggest that high metHb may not be typical of reptiles after all.

  19. Cost evaluation of a DSN high level real-time language

    NASA Technical Reports Server (NTRS)

    Mckenzie, M.

    1977-01-01

    The hypothesis that the implementation of a DSN High Level Real Time Language will reduce real time software expenditures is explored. The High Level Real Time Language is found to be both affordable and cost-effective.

  20. High-cadence observations of spicular-type events on the Sun

    NASA Astrophysics Data System (ADS)

    Shetye, J.; Doyle, J. G.; Scullion, E.; Nelson, C. J.; Kuridze, D.; Henriques, V.; Woeger, F.; Ray, T.

    2016-05-01

    Context. Chromospheric observations taken at high-cadence and high-spatial resolution show a range of spicule-like features, including Type-I, Type-II (as well as rapid blue-shifted excursions (RBEs) and rapid red-shifted excursions (RREs) which are thought to be on-disk counterparts of Type-II spicules) and those which seem to appear within a few seconds, which if interpreted as flows would imply mass flow velocities in excess of 1000 km s-1. Aims: This article seeks to quantify and study rapidly appearing spicular-type events. We also compare the multi-object multi-frame blind deconvolution (MOMFBD) and speckle reconstruction techniques to understand if these spicules are more favourably observed using a particular technique. Methods: We use spectral imaging observations taken with the CRisp Imaging SpectroPolarimeter (CRISP) on the Swedish 1-m Solar Telescope. Data was sampled at multiple positions within the Hα line profile for both an on-disk and limb location. Results: The data is host to numerous rapidly appearing features which are observed at different locations within the Hα line profile. The feature's durations vary between 10-20 s and lengths around 3500 km. Sometimes, a time delay in their appearance between the blue and red wings of 3-5 s is evident, whereas, sometimes they are near simultaneous. In some instances, features are observed to fade and then re-emerge at the same location several tens of seconds later. Conclusions: We provide the first statistical analysis of these spicules and suggest that these observations can be interpreted as the line-of-sight (LOS) movement of highly dynamic spicules moving in and out of the narrow 60 mÅ transmission filter that is used to observe in different parts of the Hα line profile. The LOS velocity component of the observed fast chromospheric features, manifested as Doppler shifts, are responsible for their appearance in the red and blue wings of Hα line. Additional work involving data at other

  1. Sleep Disrupts High-Level Speech Parsing Despite Significant Basic Auditory Processing.

    PubMed

    Makov, Shiri; Sharon, Omer; Ding, Nai; Ben-Shachar, Michal; Nir, Yuval; Zion Golumbic, Elana

    2017-08-09

    The extent to which the sleeping brain processes sensory information remains unclear. This is particularly true for continuous and complex stimuli such as speech, in which information is organized into hierarchically embedded structures. Recently, novel metrics for assessing the neural representation of continuous speech have been developed using noninvasive brain recordings that have thus far only been tested during wakefulness. Here we investigated, for the first time, the sleeping brain's capacity to process continuous speech at different hierarchical levels using a newly developed Concurrent Hierarchical Tracking (CHT) approach that allows monitoring the neural representation and processing-depth of continuous speech online. Speech sequences were compiled with syllables, words, phrases, and sentences occurring at fixed time intervals such that different linguistic levels correspond to distinct frequencies. This enabled us to distinguish their neural signatures in brain activity. We compared the neural tracking of intelligible versus unintelligible (scrambled and foreign) speech across states of wakefulness and sleep using high-density EEG in humans. We found that neural tracking of stimulus acoustics was comparable across wakefulness and sleep and similar across all conditions regardless of speech intelligibility. In contrast, neural tracking of higher-order linguistic constructs (words, phrases, and sentences) was only observed for intelligible speech during wakefulness and could not be detected at all during nonrapid eye movement or rapid eye movement sleep. These results suggest that, whereas low-level auditory processing is relatively preserved during sleep, higher-level hierarchical linguistic parsing is severely disrupted, thereby revealing the capacity and limits of language processing during sleep. SIGNIFICANCE STATEMENT Despite the persistence of some sensory processing during sleep, it is unclear whether high-level cognitive processes such as speech

  2. High energy X-ray observations of COS-B gamma-ray sources from OSO-8

    NASA Technical Reports Server (NTRS)

    Dolan, J. F.; Crannell, C. J.; Dennis, B. R.; Frost, K. J.; Orwig, L. E.; Caraveo, P. A.

    1985-01-01

    During the three years between satellite launch in June 1975 and turn-off in October 1978, the high energy X-ray spectrometer on board OSO-8 observed nearly all of the COS-B gamma-ray source positions given in the 2CG catalog (Swanenburg et al., 1981). An X-ray source was detected at energies above 20 keV at the 6-sigma level of significance in the gamma-ray error box containing 2CG342 - 02 and at the 3-sigma level of significance in the error boxes containing 2CG065 + 00, 2CG195 + 04, and 2CG311 - 01. No definite association between the X-ray and gamma-ray sources can be made from these data alone. Upper limits are given for the 2CG sources from which no X-ray flux was detected above 20 keV.

  3. Serum osteoprotegerin levels and mammographic density among high-risk women.

    PubMed

    Moran, Olivia; Zaman, Tasnim; Eisen, Andrea; Demsky, Rochelle; Blackmore, Kristina; Knight, Julia A; Elser, Christine; Ginsburg, Ophira; Zbuk, Kevin; Yaffe, Martin; Narod, Steven A; Salmena, Leonardo; Kotsopoulos, Joanne

    2018-06-01

    Mammographic density is a risk factor for breast cancer but the mechanism behind this association is unclear. The receptor activator of nuclear factor κB (RANK)/RANK ligand (RANKL) pathway has been implicated in the development of breast cancer. Given the role of RANK signaling in mammary epithelial cell proliferation, we hypothesized this pathway may also be associated with mammographic density. Osteoprotegerin (OPG), a decoy receptor for RANKL, is known to inhibit RANK signaling. Thus, it is of interest to evaluate whether OPG levels modify breast cancer risk through mammographic density. We quantified serum OPG levels in 57 premenopausal and 43 postmenopausal women using an enzyme-linked immunosorbent assay (ELISA). Cumulus was used to measure percent density, dense area, and non-dense area for each mammographic image. Subjects were classified into high versus low OPG levels based on the median serum OPG level in the entire cohort (115.1 pg/mL). Multivariate models were used to assess the relationship between serum OPG levels and the measures of mammographic density. Serum OPG levels were not associated with mammographic density among premenopausal women (P ≥ 0.42). Among postmenopausal women, those with low serum OPG levels had higher mean percent mammographic density (20.9% vs. 13.7%; P = 0.04) and mean dense area (23.4 cm 2 vs. 15.2 cm 2 ; P = 0.02) compared to those with high serum OPG levels after covariate adjustment. These findings suggest that low OPG levels may be associated with high mammographic density, particularly in postmenopausal women. Targeting RANK signaling may represent a plausible, non-surgical prevention option for high-risk women with high mammographic density, especially those with low circulating OPG levels.

  4. Why Are Most Ground Level Events Associated with High Fe/O Ratios?

    NASA Technical Reports Server (NTRS)

    von Rosenvinge, Tycho T.; Richardson, Ian G.; Cane, Hilary V.

    2010-01-01

    In a seminal paper about Ground Level Events (GLEs), Dietrich and Lopate (1999) reported on 24 GLEs from April, 1973 to May, 1998. They noted that alt but one of these GLEs, June 15, 1991, were associated with a Solar Energetic Particle (SEP) event with an enhanced Fe/O ratio. The Fe/O ratio observed for the June 15, 1991 event was only 0.03, well below the nominal coronal abundance of Fe/O = 0.134. For the remaining events, Fe/O ranged from 0.27 to over 3, welt over the nominal coronal value. During Solar Cycle 23, 14 more GLEs were observed, only one of which had very low Fe/O. This was the event of January 20, 2005, the largest ground-level neutron monitor event in 49 years. We will report on our efforts to find out whether the events of June 15, 1991 and January 20, 2005 have features in common, besides high Fe/O, that distinguish them from all other GLE events and may help determine the cause of elevated Fe/O in almost all GLE events. We will use energetic particle, magnetic field, and solar wind plasma data from NASA's IMP-8 Wind, and ACE spacecraft.

  5. Observed versus predicted carboxyhemoglobin levels in cellulose triacetate workers exposed to methylene chloride.

    PubMed

    Amsel, J; Soden, K J; Sielken, R L; Valdez-Flora, C

    2001-08-01

    Occupational exposure to methylene chloride, together with carboxyhemoglobin concentrations, has not been studied previously. Carboxyhemoglobin levels were measured in non-smoking employees exposed to varying concentrations of methylene chloride during the manufacture of cellulose triacetate fibers. The observed carboxyhemoglobin levels were compared to predicted concentrations using a pharmacokinetic model. The presence of carboxyhemoglobin in non-smokers exposed to methylene chloride results primarily from the metabolism of methylene chloride in the liver and exhibits a linear dose-response relationship. The observed levels of carboxyhemoglobin in non-smokers at the end of an 8-hour shift depend upon exposures to methylene chloride that day but are independent of occupational exposures on previous days. The observed daily concentrations of carboxyhemoglobin are consistent with predicted concentrations using a pharmacokinetic model. While varying exposure patterns were shown to change the rate of metabolite formation at the end of shift, these same exposure patterns had almost no effect on the total amount of carbon monoxide in the blood. While the present study addresses the relationship between methylene chloride, carbon monoxide, carboxyhemoglobin and ischemic heart disease, it does not address the issue of tumorigenicity, which is also the basis for the current U.S. Occupational Health and Safety workplace exposure limit of 25 ppm. This study provides support for the conclusion that the current American Conference of Governmental Industrial Hygienists 8-hour Threshold Limit Value of 50 ppm adequately protects human health with regard to ischemic heart disease and carboxyhemoglobin formation among non-smokers. Copyright 2001 Wiley-Liss, Inc.

  6. Comparative analysis of performance in reading and writing of children exposed and not exposed to high sound pressure levels.

    PubMed

    Santos, Juliana Feitosa dos; Souza, Ana Paula Ramos de; Seligman, Lilian

    2013-01-01

    To analyze the possible relationships between high sound pressure levels in the classroom and performance in the use of lexical and phonological routes in reading and writing. This consisted on a quantitative and exploratory study. The following measures were carried out: acoustic measurement, using the dosimeter, visual inspection of the external auditory canal, tonal audiometry thresholds, speech recognition tests and acoustic immittance; instrument for evaluation of reading and writing of isolated words. The non-parametric χ² test and Fisher's exact test were used for data analysis. The results of acoustic measurements in 4 schools in Santa Maria divided the sample of 87 children of third and fourth years of primary school, aged 8 to 10 years, in 2 groups. The 1st group was exposed to sound levels higher than 80 dB(A) (Study group) and the 2nd group at levels lower than 80 dB(A) (Control group). Higher prevalence of correct answers in reading and writing of nonwords, reading irregular words and frequency effect were observed. Predominance of correct answers in the writing of irregular words was observed in the Control group. For the Study group, a higher number of type errors neologism in reading and writing were observed, especially regarding the writing of nonwords and the extension effect; fewer errors of lexicalization type and verbal paragraphy in writing were observed. In assessing the reading and writing skills, children in the Study group exposed to high noise levels had poorer performance in the use of lexical and phonological routes, both in reading and in writing.

  7. ONDRAF/NIRAS and high-level radioactive waste management in Belgium

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Decamps, F.

    1993-12-31

    The National Agency for Radioactive Waste and Enriched Fissile Materials, ONDRAF/NIRAS, is a public body with legal personality in charge of managing all radioactive waste on Belgian territory, regardless of its origin and source. It is also entrusted with tasks related to the management of enriched fissile materials, plutonium containing materials and used or unused nuclear fuel, and with certain aspects of the dismantling of closed down nuclear facilities. High-level radioactive waste management comprises essentially and for the time being the storage of high-level liquid waste produced by the former EUROCHEMIC reprocessing plant and of high-level and very high-level heatmore » producing waste resulting from the reprocessing in France of Belgian spent fuel, as well as research and development (R and D) with regard to geological disposal in clay of this waste type.« less

  8. Mathematical Fundamentals of Probabilistic Semantics for High-Level Fusion

    DTIC Science & Technology

    2013-12-02

    understanding of the fundamental aspects of uncertainty representation and reasoning that a theory of hard and soft high-level fusion must encompass...representation and reasoning that a theory of hard and soft high-level fusion must encompass. Successful completion requires an unbiased, in-depth...and soft information is the lack of a fundamental HLIF theory , backed by a consistent mathematical framework and supporting algorithms. Although there

  9. Cake: Enabling High-level SLOs on Shared Storage Systems

    DTIC Science & Technology

    2012-11-07

    Cake: Enabling High-level SLOs on Shared Storage Systems Andrew Wang Shivaram Venkataraman Sara Alspaugh Randy H. Katz Ion Stoica Electrical...Date) * * * * * * * Professor R. Katz Second Reader (Date) Cake: Enabling High-level SLOs on Shared Storage Systems Andrew Wang, Shivaram Venkataraman ...Report MIT-LCS-TR-667, MIT, Laboratory for Computer Science, 1995. [39] A. Wang, S. Venkataraman , S. Alspaugh, I. Stoica, and R. Katz. Sweet storage SLOs

  10. Observed and simulated changes in Antarctic sea ice and sea level pressure: anthropogenic or natural variability? (Invited)

    NASA Astrophysics Data System (ADS)

    Hobbs, W. R.

    2013-12-01

    Statistically-significant changes in Antarctic sea ice cover and the overlying atmosphere have been observed over the last 30 years, but there is an open question of whether these changes are due to multi-decadal natural variability or an anthropogenically-forced response. A number of recent papers have shown that the slight increase in total sea ice cover is within the bounds of internal variability exhibited by coupled climate models in the CMIP5 suite. Modelled changes for the same time period generally show a decrease, but again with a magnitude that is within internal variability. However, in contrast to the Arctic, sea ice tends in the Antarctic are spatially highly heterogeneous, and consideration of the total ice cover may mask important regional signals. In this work, a robust ';fingerprinting' approach is used to show that the observed spatial pattern of sea ice trends is in fact outside simulated natural variability in west Antarctic, and furthermore that the CMIP5 models consistently show decreased ice cover in the Ross and Weddell Seas, sectors which in fact have an observed increase in cover. As a first step towards understanding the disagreement between models and observations, modelled sea level pressure trends are analysed using and optimal fingerprinting approach, to identify whether atmospheric deficiencies in the models can explain the model-observation discrepancy.

  11. High blood lead levels are associated with lead concentrations in households and day care centers attended by Brazilian preschool children.

    PubMed

    da Rocha Silva, Júlia Prestes; Salles, Fernanda Junqueira; Leroux, Isabelle Nogueira; da Silva Ferreira, Ana Paula Sacone; da Silva, Agnes Soares; Assunção, Nilson Antonio; Nardocci, Adelaide Cassia; Sayuri Sato, Ana Paula; Barbosa, Fernando; Cardoso, Maria Regina Alves; Olympio, Kelly Polido Kaneshiro

    2018-08-01

    A previous study observed high blood lead levels (BLL) in preschool children attending 50 day care centers (DCC) in São Paulo, Brazil. To identify whether lead levels found in both homes and DCC environments are associated with high blood lead levels. Children attending 4 DCCs, quoted here as NR, VA, PS and PF, were divided into two groups according to BLL: high exposure (HE: ≥13.9 μg/dL; 97.5 percentile of the 2013 year sample) and low exposure (LE: <5 μg/dL). For in situ lead measurements (lead paint mode: mg/cm 2 and ROHS mode: μg/g) in the children's households and in the DCC environments, a field portable X-ray-fluorescence analyzer was used. Multiple logistic regressions were performed to control for confounding factors. Odds ratios were adjusted for age, sex, day care center's measured lead, and tobacco. In an NR DCC building, 33.8% of the measurements had lead levels >600 μg/g, whereas such levels were observed in 77.1% of NR playground measurements. In VA DCC, 22% and 23% of the measurements in the building and in the playgrounds had levels higher than 600 μg/g, respectively. The percentage of high lead levels in the children's houses of the LE group was 5.9% (95% CI: 4.3-7.6%) and 13.2 (95% CI: 8.3-18.0%) in the HE group. Moreover, a significant association was found between high BLLs and lead levels found both in households and DCCs (p < 0.001). Most of the high lead measurements were found in tiles and playground equipment. Lead exposure estimated from the DCCs, where children spend about 10 h/day, can be as relevant as their household exposure. Therefore, public authorities should render efforts to provide a rigorous surveillance for lead-free painting supplies and for all objects offered to children. Copyright © 2018 Elsevier Ltd. All rights reserved.

  12. MYST: a comprehensive high-level AO control tool for GeMS

    NASA Astrophysics Data System (ADS)

    Rigaut, F.; Neichel, B.; Bec, M.; Garcia-Rissman, A.

    2010-07-01

    Myst is the Gemini MCAO System (GeMS) high level control GUI. It is written in yorick, python and C. In this paper, we review the software architecture of Myst and its primary purposes, which are many: Real-time display, high level diagnostics, calibrations, and executor/sequencer of high level actions (closing the loop, coordinating dithers, etc).

  13. The analysis of blood lead levels changeability over the 5-year observation in workers occupationally exposed to lead.

    PubMed

    Dobrakowski, Michał; Boroń, Marta; Kasperczyk, Sławomir; Kozłowska, Agnieszka; Kasperczyk, Aleksandra; Płachetka, Anna; Pawlas, Natalia

    2017-06-01

    The aim of the present study was to compare a group of workers with stable lead levels with a group of workers with fluctuating lead levels in terms of selected hematological, biochemical, and immunological parameters. The examined group included male workers occupationally exposed to lead. Blood lead (PbB) levels were measured every 3 months during the 5-year observation. Based on standard deviation of mean PbB levels, the examined population was divided into two groups: low level of fluctuation (L-SD) and high level of fluctuation (H-SD) groups. The mean and maximal PbB levels were significantly higher in the H-SD group than in the L-SD group by 9 and 22%, respectively. At the same time, the maximal level of zinc protoporphyrin (ZPP) and standard deviation of mean ZPP level were higher in the H-SD group by 29 and 55%, respectively. The maximal level of hemoglobin and white blood cell (WBC) count as well as standard deviation of the mean hemoglobin level and WBC count were higher in the H-SD group by 2, 8, 58, and 24%, respectively. The expression of nuclear factor kappa-B1 gene and telomerase reverse transcriptase gene was significantly greater in the H-SD group than in the L-SD group by 11 and 28%, respectively. Workers occupationally exposed to lead do not represent a homogenous population. Some present stable lead levels, whereas others have fluctuating lead levels. These fluctuations are related to secondary changes in ZPP and hemoglobin levels as well as WBC count.

  14. Final report on cermet high-level waste forms

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kobisk, E.H.; Quinby, T.C.; Aaron, W.S.

    1981-08-01

    Cermets are being developed as an alternate method for the fixation of defense and commercial high level radioactive waste in a terminal disposal form. Following initial feasibility assessments of this waste form, consisting of ceramic particles dispersed in an iron-nickel base alloy, significantly improved processing methods were developed. The characterization of cermets has continued through property determinations on samples prepared by various methods from a variety of simulated and actual high-level wastes. This report describes the status of development of the cermet waste form as it has evolved since 1977. 6 tables, 18 figures.

  15. Ontology-Based High-Level Context Inference for Human Behavior Identification

    PubMed Central

    Villalonga, Claudia; Razzaq, Muhammad Asif; Khan, Wajahat Ali; Pomares, Hector; Rojas, Ignacio; Lee, Sungyoung; Banos, Oresti

    2016-01-01

    Recent years have witnessed a huge progress in the automatic identification of individual primitives of human behavior, such as activities or locations. However, the complex nature of human behavior demands more abstract contextual information for its analysis. This work presents an ontology-based method that combines low-level primitives of behavior, namely activity, locations and emotions, unprecedented to date, to intelligently derive more meaningful high-level context information. The paper contributes with a new open ontology describing both low-level and high-level context information, as well as their relationships. Furthermore, a framework building on the developed ontology and reasoning models is presented and evaluated. The proposed method proves to be robust while identifying high-level contexts even in the event of erroneously-detected low-level contexts. Despite reasonable inference times being obtained for a relevant set of users and instances, additional work is required to scale to long-term scenarios with a large number of users. PMID:27690050

  16. Geographical distribution of drinking-water with high iodine level and association between high iodine level in drinking-water and goitre: a Chinese national investigation.

    PubMed

    Shen, Hongmei; Liu, Shoujun; Sun, Dianjun; Zhang, Shubin; Su, Xiaohui; Shen, Yanfeng; Han, Hepeng

    2011-07-01

    Excessive iodine intake can cause thyroid function disorders as can be caused by iodine deficiency. There are many people residing in areas with high iodine levels in drinking-water in China. The main aim of the present study was to map the geographical distribution of drinking-water with high iodine level in China and to determine the relationship between high iodine level in drinking-water and goitre prevalence. Iodine in drinking-water was measured in 1978 towns of eleven provinces in China, with a total of 28,857 water samples. We randomly selected children of 8-10 years old, examined the presence of goitre and measured their urinary iodine in 299 towns of nine provinces. Of the 1978 towns studied, 488 had iodine levels between 150 and 300 μg/l in drinking-water, and in 246 towns, the iodine level was >300 μg/l. These towns are mainly distributed along the original Yellow River flood areas, the second largest river in China. Of the 56 751 children examined, goitre prevalence was 6.3 % in the areas with drinking-water iodine levels of 150-300 μg/l and 11.0 % in the areas with drinking-water iodine >300 μg/l. Goitre prevalence increased with water and urinary iodine levels. For children with urinary iodine >1500 μg/l, goitre prevalence was 3.69 times higher than that for those with urinary iodine levels of 100-199 μg/l. The present study suggests that drinking-water with high iodine levels is distributed in eleven provinces of China. Goitre becomes more prevalent with the increase in iodine level in drinking-water. Therefore, it becomes important to prevent goitre through stopping the provision of iodised salt and providing normal drinking-water iodine through pipelines in these areas in China.

  17. Topological photonics: an observation of Landau levels for optical photons

    NASA Astrophysics Data System (ADS)

    Schine, Nathan; Ryou, Albert; Sommer, Ariel; Simon, Jonathan

    We present the first experimental realization of a bulk magnetic field for optical photons. By using a non-planar ring resonator, we induce an image rotation on each round trip through the resonator. This results in a Coriolis/Lorentz force and a centrifugal anticonfining force, the latter of which is cancelled by mirror curvature. Using a digital micromirror device to control both amplitude and phase, we inject arbitrary optical modes into our resonator. Spatial- and energy- resolved spectroscopy tracks photonic eigenstates as residual trapping is reduced, and we observe photonic Landau levels as the eigenstates become degenerate. We show that there is a conical geometry of the resulting manifold for photon dynamics and present a measurement of the local density of states that is consistent with Landau levels on a cone. While our work already demonstrates an integer quantum Hall material composed of photons, we have ensured compatibility with strong photon-photon interactions, which will allow quantum optical studies of entanglement and correlation in manybody systems including fractional quantum Hall fluids. This work was supported by DOE, DARPA, and AFOSR.

  18. Comparing groundwater recharge and storage variability from GRACE satellite observations with observed water levels and recharge model simulations

    NASA Astrophysics Data System (ADS)

    Allen, D. M.; Henry, C.; Demon, H.; Kirste, D. M.; Huang, J.

    2011-12-01

    Sustainable management of groundwater resources, particularly in water stressed regions, requires estimates of groundwater recharge. This study in southern Mali, Africa compares approaches for estimating groundwater recharge and understanding recharge processes using a variety of methods encompassing groundwater level-climate data analysis, GRACE satellite data analysis, and recharge modelling for current and future climate conditions. Time series data for GRACE (2002-2006) and observed groundwater level data (1982-2001) do not overlap. To overcome this problem, GRACE time series data were appended to the observed historical time series data, and the records compared. Terrestrial water storage anomalies from GRACE were corrected for soil moisture (SM) using the Global Land Data Assimilation System (GLDAS) to obtain monthly groundwater storage anomalies (GRACE-SM), and monthly recharge estimates. Historical groundwater storage anomalies and recharge were determined using the water table fluctuation method using observation data from 15 wells. Historical annual recharge averaged 145.0 mm (or 15.9% of annual rainfall) and compared favourably with the GRACE-SM estimate of 149.7 mm (or 14.8% of annual rainfall). Both records show lows and peaks in May and September, respectively; however, the peak for the GRACE-SM data is shifted later in the year to November, suggesting that the GLDAS may poorly predict the timing of soil water storage in this region. Recharge simulation results show good agreement between the timing and magnitude of the mean monthly simulated recharge and the regional mean monthly storage anomaly hydrograph generated from all monitoring wells. Under future climate conditions, annual recharge is projected to decrease by 8% for areas with luvisols and by 11% for areas with nitosols. Given this potential reduction in groundwater recharge, there may be added stress placed on an already stressed resource.

  19. High-accurate optical fiber liquid level sensor

    NASA Astrophysics Data System (ADS)

    Sun, Dexing; Chen, Shouliu; Pan, Chao; Jin, Henghuan

    1991-08-01

    A highly accurate optical fiber liquid level sensor is presented. The single-chip microcomputer is used to process and control the signal. This kind of sensor is characterized by self-security and is explosion-proof, so it can be applied in any liquid level detecting areas, especially in the oil and chemical industries. The theories and experiments about how to improve the measurement accuracy are described. The relative error for detecting the measurement range 10 m is up to 0.01%.

  20. 78 FR 70281 - United States-Mexico High Level Economic Dialogue

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-25

    ... DEPARTMENT OF COMMERCE United States-Mexico High Level Economic Dialogue AGENCY: International... stakeholder input to the Federal Register notice on the United States-Mexico High Level Economic Dialogue... economic platforms in the world. The sustained competitiveness and continued growth of the North American...

  1. Serum-free Erythroid Differentiation for Efficient Genetic Modification and High-Level Adult Hemoglobin Production.

    PubMed

    Uchida, Naoya; Demirci, Selami; Haro-Mora, Juan J; Fujita, Atsushi; Raines, Lydia N; Hsieh, Matthew M; Tisdale, John F

    2018-06-15

    In vitro erythroid differentiation from primary human cells is valuable to develop genetic strategies for hemoglobin disorders. However, current erythroid differentiation methods are encumbered by modest transduction rates and high baseline fetal hemoglobin production. In this study, we sought to improve both genetic modification and hemoglobin production among human erythroid cells in vitro . To model therapeutic strategies, we transduced human CD34 + cells and peripheral blood mononuclear cells (PBMCs) with lentiviral vectors and compared erythropoietin-based erythroid differentiation using fetal-bovine-serum-containing media and serum-free media. We observed more efficient transduction (85%-93%) in serum-free media than serum-containing media (20%-69%), whereas the addition of knockout serum replacement (KSR) was required for serum-free media to promote efficient erythroid differentiation (96%). High-level adult hemoglobin production detectable by electrophoresis was achieved using serum-free media similar to serum-containing media. Importantly, low fetal hemoglobin production was observed in the optimized serum-free media. Using KSR-containing, serum-free erythroid differentiation media, therapeutic adult hemoglobin production was detected at protein levels with β-globin lentiviral transduction in both CD34 + cells and PBMCs from sickle cell disease subjects. Our in vitro erythroid differentiation system provides a practical evaluation platform for adult hemoglobin production among human erythroid cells following genetic manipulation.

  2. Determining high touch areas in the operating room with levels of contamination.

    PubMed

    Link, Terri; Kleiner, Catherine; Mancuso, Mary P; Dziadkowiec, Oliwier; Halverson-Carpenter, Katherine

    2016-11-01

    The Centers for Disease Control and Prevention put forth the recommendation to clean areas considered high touch more frequently than minimal touch surfaces. The operating room was not included in these recommendations. The purpose of this study was to determine the most frequently touched surfaces in the operating room and their level of contamination. Phase 1 was a descriptive study to identify high touch areas in the operating room. In phase 2, high touch areas determined in phase 1 were cultured to determine if high touch areas observed were also highly contaminated and if they were more contaminated than a low touch surface. The 5 primary high touch surfaces in order were the anesthesia computer mouse, OR bed, nurse computer mouse, OR door, and anesthesia medical cart. Using the OR light as a control, this study demonstrated that a low touch area was less contaminated than the high touch areas with the exception of the OR bed. Based on information and data collected in this study, it is recommended that an enhanced cleaning protocol be established based on the most frequently touched surfaces in the operating room. Copyright © 2016 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

  3. High Level Mandatory Requirements

    DTIC Science & Technology

    2015-04-01

    standards against which they are  measured.  Definition High Level Mandatory Requirements (HLMRs) describe a set of capabilities which a project  under ...capability gap (which may already be extant, which may be developing  due to a changing  strategic  environment or which may be the result of the impending...prospective project. They  are critical to successful completion of Step 2 of the BCA, which leads to the  Strategic  Context  Document. Identification

  4. Dynamically supported geoid highs over hotspots: Observation and theory

    NASA Technical Reports Server (NTRS)

    Richards, M. A.; Hager, B. H.; Sleep, N. H.

    1986-01-01

    Hotspots are associated with long wavelength geoid highs, an association that is even stronger when the geoid highs associated with subduction zones are removed. These associations are quantified by expanding the hotspot distribution in spherical harmonics and calculating correlation coefficients as a function of harmonic degree. The hotspot distribution spectrum is essentially white, with peaks at degrees 2 and 6. It is correlated positively with the slab residual geoid for degrees 2 to 6, with low seismic velocity in the lower mantle at degree 2, and with low seismic velocity in the upper mantle at degree 6. A variety of fluid mechanical models were tested for hotspots, including lithospheric delamination and hot plumes, by calculating their predicted dynamic geoid responses and comparing them to the observations. These models include the effects of temperature dependent rheology. The preferred hotspot model, based on observations of the geoid and seismic tomography, has plumes preferentially occurring in regions of large scale background temperature highs in a mantle with substantial viscosity increase with depth, although other models are possible.

  5. Dynamically supported geoid highs over hotspots - Observation and theory

    NASA Technical Reports Server (NTRS)

    Richards, Mark A.; Hager, Bradford H.; Sleep, Norman H.

    1988-01-01

    Hotspots are associated with long wavelength geoid highs, an association that is even stronger when the geoid highs associated with subduction zones are removed. These associations are quantified by expanding the hotspot distribution in spherical harmonics and calculating correlation coefficients as a function of harmonic degree. The hotspot distribution spectrum is essentially white, with peaks at degrees 2 and 6. It is correlated positively with the slab residual geoid for degrees 2 to 6, with low seismic velocity in the lower mantle at degree 2, and with low seismic velocity in the upper mantle at degree 6. A variety of fluid mechanical models were tested for hotspots, including lithospheric delamination and hot plumes, by calculating their predicted dynamic geoid responses and comparing them to the observations. These models include the effects of temperature dependent rheology. The preferred hotspot model, based on observations of the geoid and seismic tomography, has plumes preferentially occurring in regions of large scale background temperature highs in a mantle with substantial viscosity increase with depth, although other models are possible.

  6. High level language-based robotic control system

    NASA Technical Reports Server (NTRS)

    Rodriguez, Guillermo (Inventor); Kruetz, Kenneth K. (Inventor); Jain, Abhinandan (Inventor)

    1994-01-01

    This invention is a robot control system based on a high level language implementing a spatial operator algebra. There are two high level languages included within the system. At the highest level, applications programs can be written in a robot-oriented applications language including broad operators such as MOVE and GRASP. The robot-oriented applications language statements are translated into statements in the spatial operator algebra language. Programming can also take place using the spatial operator algebra language. The statements in the spatial operator algebra language from either source are then translated into machine language statements for execution by a digital control computer. The system also includes the capability of executing the control code sequences in a simulation mode before actual execution to assure proper action at execution time. The robot's environment is checked as part of the process and dynamic reconfiguration is also possible. The languages and system allow the programming and control of multiple arms and the use of inward/outward spatial recursions in which every computational step can be related to a transformation from one point in the mechanical robot to another point to name two major advantages.

  7. High level language-based robotic control system

    NASA Technical Reports Server (NTRS)

    Rodriguez, Guillermo (Inventor); Kreutz, Kenneth K. (Inventor); Jain, Abhinandan (Inventor)

    1996-01-01

    This invention is a robot control system based on a high level language implementing a spatial operator algebra. There are two high level languages included within the system. At the highest level, applications programs can be written in a robot-oriented applications language including broad operators such as MOVE and GRASP. The robot-oriented applications language statements are translated into statements in the spatial operator algebra language. Programming can also take place using the spatial operator algebra language. The statements in the spatial operator algebra language from either source are then translated into machine language statements for execution by a digital control computer. The system also includes the capability of executing the control code sequences in a simulation mode before actual execution to assure proper action at execution time. The robot's environment is checked as part of the process and dynamic reconfiguration is also possible. The languages and system allow the programming and control of multiple arms and the use of inward/outward spatial recursions in which every computational step can be related to a transformation from one point in the mechanical robot to another point to name two major advantages.

  8. Shear Fracture of Dual Phase AHSS in the Process of Stamping: Macroscopic Failure Mode and Micro-level Metallographical Observation

    NASA Astrophysics Data System (ADS)

    Wang, Wurong; Wei, Xicheng; Yang, Jun; Shi, Gang

    2011-08-01

    Due to its excellent strength and formability combinations, dual phase (DP) steels offer the potential to improve the vehicle crashworthiness performance without increasing car body weight and have been increasingly used into new vehicles. However, a new type of crack mode termed as shear fracture is accompanied with the application of these high strength DP steel sheets. With the cup drawing experiment to identify the limit drawing ratio (LDR) of three DP AHSS with strength level from 600 MPa to 1000 MPa, the study compared and categorized the macroscopic failure mode of these three types of materials. The metallographical observation along the direction of crack was conducted for the DP steels to discover the micro-level propagation mechanism of the fracture.

  9. Spectral analysis of highly aliased sea-level signals

    NASA Astrophysics Data System (ADS)

    Ray, Richard D.

    1998-10-01

    Observing high-wavenumber ocean phenomena with a satellite altimeter generally calls for "along-track" analyses of the data: measurements along a repeating satellite ground track are analyzed in a point-by-point fashion, as opposed to spatially averaging data over multiple tracks. The sea-level aliasing problems encountered in such analyses can be especially challenging. For TOPEX/POSEIDON, all signals with frequency greater than 18 cycles per year (cpy), including both tidal and subdiurnal signals, are folded into the 0-18 cpy band. Because the tidal bands are wider than 18 cpy, residual tidal cusp energy, plus any subdiurnal energy, is capable of corrupting any low-frequency signal of interest. The practical consequences of this are explored here by using real sea-level measurements from conventional tide gauges, for which the true oceanographic spectrum is known and to which a simulated "satellite-measured" spectrum, based on coarsely subsampled data, may be compared. At many locations the spectrum is sufficently red that interannual frequencies remain unaffected. Intra-annual frequencies, however, must be interpreted with greater caution, and even interannual frequencies can be corrupted if the spectrum is flat. The results also suggest that whenever tides must be estimated directly from the altimetry, response methods of analysis are preferable to harmonic methods, even in nonlinear regimes; this will remain so for the foreseeable future. We concentrate on three example tide gauges: two coastal stations on the Malay Peninsula where the closely aliased K1 and Ssa tides are strong and at Canton Island where trapped equatorial waves are aliased.

  10. Observation of b 2 symmetry vibrational levels of the SO 2C 1B 2 state: Vibrational level staggering, Coriolis interactions, and rotation-vibration constants

    DOE PAGES

    Park, G. Barratt; Jiang, Jun; Saladrigas, Catherine A.; ...

    2016-04-14

    Here, the C 1B 2 state of SO 2 has a double-minimum potential in the antisymmetric stretch coordinate, such that the minimum energy geometry has nonequivalent SO bond lengths. However, low-lying levels with odd quanta of antisymmetric stretch (b 2 vibrational symmetry) have not previously been observed because transitions into these levels from the zero-point level of the X ~ state are vibronically forbidden. We use IR-UV double resonance to observe the b 2 vibrational levels of the C state below 1600 cm –1 of vibrational excitation. This enables a direct characterization of the vibrational level staggering that results frommore » the double-minimum potential. In addition, it allows us to deperturb the strong c-axis Coriolis interactions between levels of a 1 and b 2 vibrational symmetry, and to determine accurately the vibrational dependence of the rotational constants in the distorted C electronic state.« less

  11. Observation of b 2 symmetry vibrational levels of the SO 2C 1B 2 state: Vibrational level staggering, Coriolis interactions, and rotation-vibration constants

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Park, G. Barratt; Jiang, Jun; Saladrigas, Catherine A.

    Here, the C 1B 2 state of SO 2 has a double-minimum potential in the antisymmetric stretch coordinate, such that the minimum energy geometry has nonequivalent SO bond lengths. However, low-lying levels with odd quanta of antisymmetric stretch (b 2 vibrational symmetry) have not previously been observed because transitions into these levels from the zero-point level of the X ~ state are vibronically forbidden. We use IR-UV double resonance to observe the b 2 vibrational levels of the C state below 1600 cm –1 of vibrational excitation. This enables a direct characterization of the vibrational level staggering that results frommore » the double-minimum potential. In addition, it allows us to deperturb the strong c-axis Coriolis interactions between levels of a 1 and b 2 vibrational symmetry, and to determine accurately the vibrational dependence of the rotational constants in the distorted C electronic state.« less

  12. Depression in type 1 diabetes was associated with high levels of circulating galectin-3

    PubMed Central

    Melin, Eva Olga; Dereke, Jonatan; Thunander, Maria; Hillman, Magnus

    2018-01-01

    Objective Neuroinflammatory responses are implicated in depression. The aim was to explore whether depression in patients with type 1 diabetes (T1D) was associated with high circulating galectin-3, controlling for metabolic variables, s-creatinine, life style factors, medication and cardiovascular complications. Design Cross-sectional. Methods Participants were T1D patients (n = 283, 56% men, age 18–59 years, diabetes duration ≥1 year). Depression was assessed by Hospital Anxiety and Depression Scale-depression subscale. Blood samples, anthropometrics and blood pressure were collected, and supplemented with data from medical records and the Swedish National Diabetes Registry. Galectin-3 ≥2.562 µg/l, corresponding to the 85th percentile, was defined as high galectin-3. Results Median (quartile1, quartile3) galectin-3 (µg/l) was 1.3 (0.8, 2.9) for the 30 depressed patients, and 0.9 (0.5, 1.6) for the 253 non-depressed, P = 0.009. Depression was associated with high galectin-3 in all the 283 patients (adjusted odds ratio (AOR) 3.5), in the 161 men (AOR 3.4), and in the 122 women (AOR 3.9). HbA1c, s-lipids, s-creatinine, blood pressure, obesity, smoking, physical inactivity, cardiovascular complications and drugs (antihypertensive, lipid lowering, oral antidiabetic drugs and antidepressants) were not associated with high galectin-3. Conclusions This is the first study to show an association between depression and galectin-3. Depression was the only explored parameter associated with high circulating galectin-3 levels in 283 T1D patients. High galectin-3 levels might contribute to the increased risk for Alzheimer’s disease, cardiovascular and all-cause mortality observed in persons with depression. Potentially, in the future, treatment targeting galactin-3 might improve the prognosis for patients with high galectin-3 levels. PMID:29760188

  13. High-level pullulan production by Aureobasidium pullulans var. melanogenium P16 isolated from mangrove system.

    PubMed

    Ma, Zai-Chao; Fu, Wen-Juan; Liu, Guang-Lei; Wang, Zhi-Peng; Chi, Zhen-Ming

    2014-06-01

    After over 100 strains of Aureobasidium spp. isolated from mangrove system were screened for their ability to produce exopolysaccharide (EPS), it was found that Aureobasidium pullulans var. melanogenium P16 strain among them could produce high level of EPS. Under the optimal conditions, 65.3 g/L EPS was produced by the P16 strain within 120 h at flask level. During 10-L batch fermentation, when the medium contained 120.0 g/L sucrose, 67.4 g/L of EPS and 23.1 g/L of cell dry weight in the culture were obtained within 120 h, leaving 0.78 g/L of reducing sugar and 11.4 g/L of total sugar in the fermented medium. It should be stressed that during the fermentation, no melanin was observed. After purification, the purified EPS was confirmed to be pullulan. This is the first time to report that A. pullulans var. melanogenium P16 strain isolated from the mangrove system can produce high level of pullulan.

  14. Warm-Up Activities of Middle and High School Band Directors Participating in State-Level Concert Band Assessments

    ERIC Educational Resources Information Center

    Ward, Justin P.; Hancock, Carl B.

    2016-01-01

    The purpose of this study was to examine the warm-ups chosen by concert band directors participating in state-level performance assessments. We observed 29 middle and high school bands and coded the frequency and duration of warm-up activities and behaviors. Results indicated that most bands rehearsed music and played scales, long tones, and…

  15. Investigation of Ground-Level Ozone and High-Pollution Episodes in a Megacity of Eastern China

    PubMed Central

    Zhao, Heng; Wang, Shanshan; Wang, Wenxin; Liu, Rui; Zhou, Bin

    2015-01-01

    Differential Optical Absorption Spectroscopy (DOAS) was used for the long-term observation of ground-level ozone (O3) from March 2010 to March 2013 over Shanghai, China. The 1-hour average concentration of O3 was 27.2 ± 17.0 ppbv. O3 level increased during spring, reached the peak in late spring and early summer, and then decreased in autumn and finally dropped to the bottom in winter. The highest monthly average O3 concentration in June (41.1 ppbv) was nearly three times as high as the lowest level recorded in December (15.2 ppbv). In terms of pollution episodes, 56 hourly samples (on 14 separate days) in 2010 exceeded the 1-hour ozone limit of 200 μg/m3 specified by the Grade II of the Chinese Ambient Air Quality Standards (CAAQS, revised GB 3095-2012). Utilizing the Hybrid Single Particle Lagrangian Integrated Trajectory (HYSPLIT) model, the primary contribution to high ozone days (HODs) was identified as the regional transportation of volatile organic compounds (VOC) and high concentrations of O3 from the chemical industrial zone in the Jinshan district of Shanghai. HODs showed higher concentrations of HONO and NO2 than non-episode conditions, implying that HONO at high concentration during HODs was capable of increasing the O3 concentration. The photolysis rate of HONO was estimated, suggesting that the larger number of OH radicals resulting from high concentrations of HONO have a considerable impact on ozone concentrations. PMID:26121146

  16. Observing exoplanet populations with high-precision astrometry

    NASA Astrophysics Data System (ADS)

    Sahlmann, Johannes

    2012-06-01

    This thesis deals with the application of the astrometry technique, consisting in measuring the position of a star in the plane of the sky, for the discovery and characterisation of extra-solar planets. It is feasible only with a very high measurement precision, which motivates the use of space observatories, the development of new ground-based astronomical instrumentation and of innovative data analysis methods: The study of Sun-like stars with substellar companions using CORALIE radial velocities and HIPPARCOS astrometry leads to the determination of the frequency of close brown dwarf companions and to the discovery of a dividing line between massive planets and brown dwarf companions; An observation campaign employing optical imaging with a very large telescope demonstrates sufficient astrometric precision to detect planets around ultra-cool dwarf stars and the first results of the survey are presented; Finally, the design and initial astrometric performance of PRIMA, ! a new dual-feed near-infrared interferometric observing facility for relative astrometry is presented.

  17. Parallel Evolution of High-Level Aminoglycoside Resistance in Escherichia coli Under Low and High Mutation Supply Rates.

    PubMed

    Ibacache-Quiroga, Claudia; Oliveros, Juan C; Couce, Alejandro; Blázquez, Jesus

    2018-01-01

    Antibiotic resistance is a major concern in public health worldwide, thus there is much interest in characterizing the mutational pathways through which susceptible bacteria evolve resistance. Here we use experimental evolution to explore the mutational pathways toward aminoglycoside resistance, using gentamicin as a model, under low and high mutation supply rates. Our results show that both normo and hypermutable strains of Escherichia coli are able to develop resistance to drug dosages > 1,000-fold higher than the minimal inhibitory concentration for their ancestors. Interestingly, such level of resistance was often associated with changes in susceptibility to other antibiotics, most prominently with increased resistance to fosfomycin. Whole-genome sequencing revealed that all resistant derivatives presented diverse mutations in five common genetic elements: fhuA, fusA and the atpIBEFHAGDC, cyoABCDE , and potABCD operons. Despite the large number of mutations acquired, hypermutable strains did not pay, apparently, fitness cost. In contrast to recent studies, we found that the mutation supply rate mainly affected the speed (tempo) but not the pattern (mode) of evolution: both backgrounds acquired the mutations in the same order, although the hypermutator strain did it faster. This observation is compatible with the adaptive landscape for high-level gentamicin resistance being relatively smooth, with few local maxima; which might be a common feature among antibiotics for which resistance involves multiple loci.

  18. Parallel Evolution of High-Level Aminoglycoside Resistance in Escherichia coli Under Low and High Mutation Supply Rates

    PubMed Central

    Ibacache-Quiroga, Claudia; Oliveros, Juan C.; Couce, Alejandro; Blázquez, Jesus

    2018-01-01

    Antibiotic resistance is a major concern in public health worldwide, thus there is much interest in characterizing the mutational pathways through which susceptible bacteria evolve resistance. Here we use experimental evolution to explore the mutational pathways toward aminoglycoside resistance, using gentamicin as a model, under low and high mutation supply rates. Our results show that both normo and hypermutable strains of Escherichia coli are able to develop resistance to drug dosages > 1,000-fold higher than the minimal inhibitory concentration for their ancestors. Interestingly, such level of resistance was often associated with changes in susceptibility to other antibiotics, most prominently with increased resistance to fosfomycin. Whole-genome sequencing revealed that all resistant derivatives presented diverse mutations in five common genetic elements: fhuA, fusA and the atpIBEFHAGDC, cyoABCDE, and potABCD operons. Despite the large number of mutations acquired, hypermutable strains did not pay, apparently, fitness cost. In contrast to recent studies, we found that the mutation supply rate mainly affected the speed (tempo) but not the pattern (mode) of evolution: both backgrounds acquired the mutations in the same order, although the hypermutator strain did it faster. This observation is compatible with the adaptive landscape for high-level gentamicin resistance being relatively smooth, with few local maxima; which might be a common feature among antibiotics for which resistance involves multiple loci. PMID:29615988

  19. Isolation of high quality RNA from cereal seeds containing high levels of starch.

    PubMed

    Wang, Guifeng; Wang, Gang; Zhang, Xiaowei; Wang, Fang; Song, Rentao

    2012-01-01

    Cereals are an important source of food, feed and fuel with a rapidly increasing global demand. However, cereal seeds contain high levels of starch and polysaccharides, making the isolation of high quality RNA extremely difficult. To develop a novel method for extracting high quality total RNA from various starch- and polysaccharides-rich cereal seeds, such as maize, rice, sorghum and wheat. We developed a modified sodium dodecyl sulphate (SDS)/TRIzol method. The combined use of a Tris buffer (pH 9.0) and SDS before TRIzol extraction effectively resolved the problem of seed homogenate solidification in such a buffer. A high concentration of SDS was used separately, not only to promote cell lysis but also to effectively dissolve seed sample containing high levels of starch. Moreover, acid phenol saturated with 0.1  M citrate buffer (pH 4.3) was used to separate RNA from DNAs, proteins and high levels of starch. This rapid protocol was compared with other RNA isolation methods preferentially used for plants rich in polysaccharides and secondary metabolites. Gel electrophoresis analysis indicated that the extracted total RNA had good integrity without apparent DNA contamination. Furthermore, an A₂₆₀/₂₈₀ ratio of approximately 2.0, an A₂₆₀/₂₃₀ ratio of more than 2.0 and RIN values of more than 8.6 indicated that the isolated RNA was of high purity. The isolated RNA was suitable for subsequent molecular manipulations, such as reverse-transcription polymerase chain reaction (PCR), rapid amplification of cDNA ends (RACE) and real-time PCR. The study has described an easy, efficient and highly reproducible method for RNA isolation from various cereal seeds. Copyright © 2011 John Wiley & Sons, Ltd.

  20. Preliminary Flight Deck Observations During Flight in High Ice Water Content Conditions

    NASA Technical Reports Server (NTRS)

    Ratvasky, Thomas; Duchanoy, Dominque; Bourdinot, Jean-Francois; Harrah, Steven; Strapp, Walter; Schwarzenboeck, Alfons; Dezitter, Fabien; Grandin, Alice

    2015-01-01

    In 2006, Mason et al. identified common observations that occurred in engine power-loss events attributed to flight in high concentrations of ice crystals. Observations included light to moderate turbulence, precipitation on the windscreen (often reported as rain), aircraft total temperature anomalies, lack of significant airframe icing, and no flight radar echoes at the location and altitude of the engine event. Since 2006, Mason et al. and others have collected information from pilots who experienced engine power-loss events via interviews and questionnaires to substantiate earlier observations and support event analyses. In 2011, Mason and Grzych reported that vertical acceleration data showed increases in turbulence prior to engine events, although the turbulence was usually light to moderate and not unique to high ice water content (HIWC) clouds. Mason concluded that the observation of rain on the windscreen was due to melting of ice high concentrations of ice crystals on the windscreen, coalescing into drops. Mason also reported that these pilot observations of rain on the windscreen were varied. Many pilots indicated no rain was observed, while others observed moderate rain with unique impact sounds. Mason concluded that the variation in the reports may be due to variation in the ice concentration, particle size, and temperature.

  1. Coastal barrier stratigraphy for Holocene high-resolution sea-level reconstruction

    PubMed Central

    Costas, Susana; Ferreira, Óscar; Plomaritis, Theocharis A.; Leorri, Eduardo

    2016-01-01

    The uncertainties surrounding present and future sea-level rise have revived the debate around sea-level changes through the deglaciation and mid- to late Holocene, from which arises a need for high-quality reconstructions of regional sea level. Here, we explore the stratigraphy of a sandy barrier to identify the best sea-level indicators and provide a new sea-level reconstruction for the central Portuguese coast over the past 6.5 ka. The selected indicators represent morphological features extracted from coastal barrier stratigraphy, beach berm and dune-beach contact. These features were mapped from high-resolution ground penetrating radar images of the subsurface and transformed into sea-level indicators through comparison with modern analogs and a chronology based on optically stimulated luminescence ages. Our reconstructions document a continuous but slow sea-level rise after 6.5 ka with an accumulated change in elevation of about 2 m. In the context of SW Europe, our results show good agreement with previous studies, including the Tagus isostatic model, with minor discrepancies that demand further improvement of regional models. This work reinforces the potential of barrier indicators to accurately reconstruct high-resolution mid- to late Holocene sea-level changes through simple approaches. PMID:27929122

  2. Coastal barrier stratigraphy for Holocene high-resolution sea-level reconstruction.

    PubMed

    Costas, Susana; Ferreira, Óscar; Plomaritis, Theocharis A; Leorri, Eduardo

    2016-12-08

    The uncertainties surrounding present and future sea-level rise have revived the debate around sea-level changes through the deglaciation and mid- to late Holocene, from which arises a need for high-quality reconstructions of regional sea level. Here, we explore the stratigraphy of a sandy barrier to identify the best sea-level indicators and provide a new sea-level reconstruction for the central Portuguese coast over the past 6.5 ka. The selected indicators represent morphological features extracted from coastal barrier stratigraphy, beach berm and dune-beach contact. These features were mapped from high-resolution ground penetrating radar images of the subsurface and transformed into sea-level indicators through comparison with modern analogs and a chronology based on optically stimulated luminescence ages. Our reconstructions document a continuous but slow sea-level rise after 6.5 ka with an accumulated change in elevation of about 2 m. In the context of SW Europe, our results show good agreement with previous studies, including the Tagus isostatic model, with minor discrepancies that demand further improvement of regional models. This work reinforces the potential of barrier indicators to accurately reconstruct high-resolution mid- to late Holocene sea-level changes through simple approaches.

  3. Observations of High Energy Cosmic Ray Electrons by the ATIC Balloon Experiment

    NASA Technical Reports Server (NTRS)

    Guzik, T. G.; Chang, J.; Adams, J. H., Jr.; Ahn, H. S.; Bashindzhagyan, G. L.; Christl, M.; Isbert, J.; Kim, K. C.; Kuznetsov, E. N.; Panasyuk, M. I.; hide

    2009-01-01

    Recently the Advanced Thin Ionization Calorimeter (ATIC) balloon experiment reported observations of high energy cosmic ray electrons over the energy range 300 to 800 GeV, indicating a feature or "bump" in the otherwise smoothly decreasing energy spectrum. The severe energy losses that occur as these high energy particles traverse the galaxy render the cosmic ray electron spectrum sensitive to local (a few kiloparsecs) sources and hence very interesting. The ATIC results are the first time that such a cosmic ray spectrum anomaly has been observed at high energy. Potential sources of this electron excess include pulsars, microquasars, supernovae remnants as well as the annihilation of exotic dark matter candidate particles. ATIC has had three successful high altitude flights over the continent of Antarctica 2000-2001, 2002-2003 and 2007-2008. Only results from the first two flights have been reported so far. During this talk we will discuss the ATIC experiment, the electron observations (including preliminary results from the most recent ATIC flight), examine the merits of the various source models and compare the ATIC observations with other recent measurements.

  4. Melanoma cells present high levels of HLA-A2-tyrosinase in association with instability and aberrant intracellular processing of tyrosinase.

    PubMed

    Michaeli, Yael; Sinik, Keren; Haus-Cohen, Maya; Reiter, Yoram

    2012-04-01

    Short-lived protein translation products are proposed to be a major source of substrates for major histocompatibility complex (MHC) class I antigen processing and presentation; however, a direct link between protein stability and the presentation level of MHC class I-peptide complexes has not been made. We have recently discovered that the peptide Tyr((369-377)) , derived from the tyrosinase protein is highly presented by HLA-A2 on the surface of melanoma cells. To examine the molecular mechanisms responsible for this presentation, we compared characteristics of tyrosinase in melanoma cells lines that present high or low levels of HLA-A2-Tyr((369-377)) complexes. We found no correlation between mRNA levels and the levels of HLA-A2-Tyr((369-377)) presentation. Co-localization experiments revealed that, in cell lines presenting low levels of HLA-A2-Tyr((369-377)) complexes, tyrosinase co-localizes with LAMP-1, a melanosome marker, whereas in cell lines presenting high HLA-A2-Tyr((369-377)) levels, tyrosinase localizes to the endoplasmic reticulum. We also observed differences in tyrosinase molecular weight and glycosylation composition as well as major differences in protein stability (t(1/2) ). By stabilizing the tyrosinase protein, we observed a dramatic decrease in HLA-A2-tyrosinase presentation. Our findings suggest that aberrant processing and instability of tyrosinase are responsible for the high presentation of HLA-A2-Tyr((369-377)) complexes and thus shed new light on the relationship between intracellular processing, stability of proteins, and MHC-restricted peptide presentation. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Landau level splitting in Cd3As2 under high magnetic fields

    NASA Astrophysics Data System (ADS)

    Zhang, Cheng; Cao, Junzhi; Liang, Sihang; Xia, Zhengcai; Li, Liang; Xiu, Faxian

    2015-03-01

    Three-dimensional (3D) topological Dirac semimetals (TDSs) are a new kind of Dirac materials that adopt nontrivial topology in band structure and possess degenerated massless Dirac fermions in the bulk. It has been proposed that TDSs can be driven to other exotic phases like Weyl semimetals, topological insulators and topological superconductors by breaking certain symmetries. Here we report the first transport evidence of Landau level splitting in TDS Cd3As2 single crystals under high magnetic fields, suggesting the removal of spin degeneracy by breaking time reversal symmetry (TRS). The observed Landau level splitting is originated from the joint contributions of orbit and Zeeman splitting in Cd3As2. In addition, the detected Berry phase is found to vary from nontrivial to trivial at different field directions, revealing a fierce competition between the orbit-coupled field strength and the field-generated mass term. Our results demonstrate a feasible path to generate a Weyl semimetal phase based on the TDSs by breaking TRS.

  6. High-k shallow traps observed by charge pumping with varying discharging times

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ho, Szu-Han; Chen, Ching-En; Tseng, Tseung-Yuen

    2013-11-07

    In this paper, we investigate the influence of falling time and base level time on high-k bulk shallow traps measured by charge pumping technique in n-channel metal-oxide-semiconductor field-effect transistors with HfO{sub 2}/metal gate stacks. N{sub T}-V{sub high} {sub level} characteristic curves with different duty ratios indicate that the electron detrapping time dominates the value of N{sub T} for extra contribution of I{sub cp} traps. N{sub T} is the number of traps, and I{sub cp} is charge pumping current. By fitting discharge formula at different temperatures, the results show that extra contribution of I{sub cp} traps at high voltage are inmore » fact high-k bulk shallow traps. This is also verified through a comparison of different interlayer thicknesses and different Ti{sub x}N{sub 1−x} metal gate concentrations. Next, N{sub T}-V{sub high} {sub level} characteristic curves with different falling times (t{sub falling} {sub time}) and base level times (t{sub base} {sub level}) show that extra contribution of I{sub cp} traps decrease with an increase in t{sub falling} {sub time}. By fitting discharge formula for different t{sub falling} {sub time}, the results show that electrons trapped in high-k bulk shallow traps first discharge to the channel and then to source and drain during t{sub falling} {sub time}. This current cannot be measured by the charge pumping technique. Subsequent measurements of N{sub T} by charge pumping technique at t{sub base} {sub level} reveal a remainder of electrons trapped in high-k bulk shallow traps.« less

  7. The effects of illumination on deep levels observed in as-grown and low-energy electron irradiated high-purity semi-insulating 4H-SiC

    NASA Astrophysics Data System (ADS)

    Alfieri, G.; Knoll, L.; Kranz, L.; Sundaramoorthy, V.

    2018-05-01

    High-purity semi-insulating 4H-SiC can find a variety of applications, ranging from power electronics to quantum computing applications. However, data on the electronic properties of deep levels in this material are scarce. For this reason, we present a deep level transient spectroscopy study on HPSI 4H-SiC substrates, both as-grown and irradiated with low-energy electrons (to displace only C-atoms). Our investigation reveals the presence of four deep levels with activation energies in the 0.4-0.9 eV range. The concentrations of three of these levels increase by at least one order of magnitude after irradiation. Furthermore, we analyzed the behavior of these traps under sub- and above-band gap illumination. The nature of the traps is discussed in the light of the present data and results reported in the literature.

  8. High BIM mRNA levels are associated with longer survival in advanced gastric cancer.

    PubMed

    Wu, Nandie; Huang, Ying; Zou, Zhengyun; Gimenez-Capitan, Ana; Yu, Lixia; Hu, Wenjing; Zhu, Lijing; Sun, Xia; Sanchez, Jose Javier; Guan, Wenxian; Liu, Baorui; Rosell, Rafael; Wei, Jia

    2017-03-01

    Chemotherapy drugs, including 5-fluorouracil (5-FU), oxaliplatin and docetaxel, are commonly used in the treatment of gastric cancer (GC). Apoptosis-relevant genes may be associated with drug resistance. In the present study, the messenger RNA (mRNA) expression levels of B-cell lymphoma 2 interacting mediator of cell death (BIM), astrocyte elevated gene-1 (AEG-1) and AXL receptor tyrosine kinase (AXL) were investigated in 131 advanced GC samples, and the expression levels of these genes were correlated with patients' overall survival (OS). All 131 patients received first-line FOLFOX combination chemotherapy with folinic acid and 5-FU, in which 56 patients were further treated with second-line docetaxel-based chemotherapy. A correlation between the mRNA expression levels of BIM and AEG-1 was observed ( r s =0.30; P=0.002). There was no association between the mRNA expression levels of any of the individual genes analyzed and OS in patients only receiving first-line FOLFOX chemotherapy. In a subgroup of patients receiving docetaxel-based second-line chemotherapy, those with high or intermediate levels of BIM exhibited a median OS of 18.2 months [95% confidence interval (CI), 12.8-23.6], compared with 9.6 months (95% CI, 8.9-10.3) in patients with low BIM levels (P=0.008). However, there was no correlation between the mRNA expression levels of AEG-1 or AXL and OS. The risk of mortality was higher in patients with low BIM mRNA levels than in those with high or intermediate BIM mRNA levels (hazard ratio, 2.61; 95% CI, 1.21-5.62; P=0.010). Therefore, BIM may be considered as a biomarker to identify whether patients could benefit from docetaxel-based second-line chemotherapy in GC.

  9. Observing the high redshift Universe with Euclid

    NASA Astrophysics Data System (ADS)

    Laureijs, René; Euclid Collaboration

    2018-05-01

    Euclid enables the exploration of large sky areas with diffraction limited resolution in the optical and near-infrared, and is sensitive enough to detect targets at cosmological distances. This combination of capabilities gives Euclid a clear advantage over telescope facilities with larger apertures, both on ground and in space. The decision to mount in the NISP instrument one extra grism for the wavelength range 0.92-1.3 μm with a spectral resolution of R ~260 makes possible a rest-frame UV survey of the early Universe in the redshift range 6.5 < z < 9.7. Euclid's standard imaging with VIS in the 0.55-0.9 μm band and with NISP in the Y, J, H bands provide complementary photometry for further target identification and characterization. Euclid is a suitable facility to discover and map the spatial distribution of rare high-redshift targets and to collect statistically relevant samples, in particular of high redshift Lyα emitters and QSOs, which can be used as signposts of the cosmic structures. The Euclid surveys are also a starting point for deeper follow up observations of the individual high-z objects. We present the Euclid mission and discuss the detectability of high-z objects to probe the epoch of ionization.

  10. FERMI observations of high-energy gamma-ray emission from GRB 090217A

    DOE PAGES

    Ackermann, M.; Ajello, M.; Baldini, L.; ...

    2010-06-22

    The Fermi observatory is advancing our knowledge of gamma-ray bursts (GRBs) through pioneering observations at high energies, covering more than seven decades in energy with the two on-board detectors, the Large Area Telescope (LAT) and the Gamma-ray Burst Monitor (GBM). Here, we report on the observation of the long GRB 090217A which triggered the GBM and has been detected by the LAT with a significance greater than 9σ. We present the GBM and LAT observations and on-ground analyses, including the time-resolved spectra and the study of the temporal profile from 8 keV up to ~1 GeV. All spectra are wellmore » reproduced by a Band model. We compare these observations to the first two LAT-detected, long bursts GRB 080825C and GRB 080916C. These bursts were found to have time-dependent spectra and exhibited a delayed onset of the high-energy emission, which are not observed in the case of GRB 090217A. We discuss some theoretical implications for the high-energy emission of GRBs.« less

  11. Testing the high turbulence level breakdown of low-frequency gyrokinetics against high-frequency cyclokinetic simulations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Deng, Zhao, E-mail: zhao.deng@foxmail.com; Waltz, R. E.

    2015-05-15

    This paper presents numerical simulations of the nonlinear cyclokinetic equations in the cyclotron harmonic representation [R. E. Waltz and Zhao Deng, Phys. Plasmas 20, 012507 (2013)]. Simulations are done with a local flux-tube geometry and with the parallel motion and variation suppressed using a newly developed rCYCLO code. Cyclokinetic simulations dynamically follow the high-frequency ion gyro-phase motion which is nonlinearly coupled into the low-frequency drift-waves possibly interrupting and suppressing gyro-averaging and increasing the transport over gyrokinetic levels. By comparing the more fundamental cyclokinetic simulations with the corresponding gyrokinetic simulations, the breakdown of gyrokinetics at high turbulence levels is quantitatively testedmore » over a range of relative ion cyclotron frequency 10 < Ω*{sup  }< 100 where Ω*{sup  }= 1/ρ*, and ρ* is the relative ion gyroradius. The gyrokinetic linear mode rates closely match the cyclokinetic low-frequency rates for Ω*{sup  }> 5. Gyrokinetic transport recovers cyclokinetic transport at high relative ion cyclotron frequency (Ω*{sup  }≥ 50) and low turbulence level as required. Cyclokinetic transport is found to be lower than gyrokinetic transport at high turbulence levels and low-Ω* values with stable ion cyclotron (IC) modes. The gyrokinetic approximation is found to break down when the density perturbations exceed 20%. For cyclokinetic simulations with sufficiently unstable IC modes and sufficiently low Ω*{sup  }∼ 10, the high-frequency component of cyclokinetic transport level can exceed the gyrokinetic transport level. However, the low-frequency component of the cyclokinetic transport and turbulence level does not exceed that of gyrokinetics. At higher and more physically relevant Ω*{sup  }≥ 50 values and physically realistic IC driving rates, the low-frequency component of the cyclokinetic transport and turbulence level is still smaller than that of

  12. Are fluoride levels in drinking water associated with hypothyroidism prevalence in England? A large observational study of GP practice data and fluoride levels in drinking water.

    PubMed

    Peckham, S; Lowery, D; Spencer, S

    2015-07-01

    While previous research has suggested that there is an association between fluoride ingestion and the incidence of hypothyroidism, few population level studies have been undertaken. In England, approximately 10% of the population live in areas with community fluoridation schemes and hypothyroidism prevalence can be assessed from general practice data. This observational study examines the association between levels of fluoride in water supplies with practice level hypothyroidism prevalence. We used a cross-sectional study design using secondary data to develop binary logistic regression models of predictive factors for hypothyroidism prevalence at practice level using 2012 data on fluoride levels in drinking water, 2012/2013 Quality and Outcomes Framework (QOF) diagnosed hypothyroidism prevalence data, 2013 General Practitioner registered patient numbers and 2012 practice level Index of Multiple Deprivation scores. We found that higher levels of fluoride in drinking water provide a useful contribution for predicting prevalence of hypothyroidism. We found that practices located in the West Midlands (a wholly fluoridated area) are nearly twice as likely to report high hypothyroidism prevalence in comparison to Greater Manchester (non-fluoridated area). In many areas of the world, hypothyroidism is a major health concern and in addition to other factors-such as iodine deficiency-fluoride exposure should be considered as a contributing factor. The findings of the study raise particular concerns about the validity of community fluoridation as a safe public health measure. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  13. Space augmentation of military high-level waste disposal

    NASA Technical Reports Server (NTRS)

    English, T.; Lees, L.; Divita, E.

    1979-01-01

    Space disposal of selected components of military high-level waste (HLW) is considered. This disposal option offers the promise of eliminating the long-lived radionuclides in military HLW from the earth. A space mission which meets the dual requirements of long-term orbital stability and a maximum of one space shuttle launch per week over a period of 20-40 years, is a heliocentric orbit about halfway between the orbits of earth and Venus. Space disposal of high-level radioactive waste is characterized by long-term predictability and short-term uncertainties which must be reduced to acceptably low levels. For example, failure of either the Orbit Transfer Vehicle after leaving low earth orbit, or the storable propellant stage failure at perihelion would leave the nuclear waste package in an unplanned and potentially unstable orbit. Since potential earth reencounter and subsequent burn-up in the earth's atmosphere is unacceptable, a deep space rendezvous, docking, and retrieval capability must be developed.

  14. Observations of high droplet number concentrations in Southern Ocean boundary layer clouds

    NASA Astrophysics Data System (ADS)

    Chubb, T.; Huang, Y.; Jensen, J.; Campos, T.; Siems, S.; Manton, M.

    2015-09-01

    Data from the standard cloud physics payload during the NSF/NCAR High-performance Instrumented Airborne Platform for Environmental Research (HIAPER) Pole-to-Pole Observations (HIPPO) campaigns provide a snapshot of unusual wintertime microphysical conditions in the boundary layer over the Southern Ocean. On 29 June 2011, the HIAPER sampled the boundary layer in a region of pre-frontal warm air advection between 58 and 48° S to the south of Tasmania. Cloud droplet number concentrations were consistent with climatological values in the northernmost profiles but were exceptionally high for wintertime in the Southern Ocean at 100-200 cm-3 in the southernmost profiles. Sub-micron (0.06observations revealed that while conditions in the troposphere were more typical of a clean remote ocean airmass, there was some evidence of continental or anthropogenic influence. However, the hypothesis of long range transport of continental aerosol fails to explain the magnitude of the aerosol and cloud droplet concentration in the boundary layer. Instead, the gale force surface winds in this case (wind speed at 167 m above sea level was >25 m s-1) were most likely responsible for production of sea spray aerosol which influenced the microphysical properties of the boundary layer clouds. The smaller size and higher number concentration of cloud droplets is inferred to increase the albedo of these clouds, and these conditions occur regularly, and are expected to increase in frequency, over windy parts of the Southern Ocean.

  15. Preprocessing of gravity gradients at the GOCE high-level processing facility

    NASA Astrophysics Data System (ADS)

    Bouman, Johannes; Rispens, Sietse; Gruber, Thomas; Koop, Radboud; Schrama, Ernst; Visser, Pieter; Tscherning, Carl Christian; Veicherts, Martin

    2009-07-01

    One of the products derived from the gravity field and steady-state ocean circulation explorer (GOCE) observations are the gravity gradients. These gravity gradients are provided in the gradiometer reference frame (GRF) and are calibrated in-flight using satellite shaking and star sensor data. To use these gravity gradients for application in Earth scienes and gravity field analysis, additional preprocessing needs to be done, including corrections for temporal gravity field signals to isolate the static gravity field part, screening for outliers, calibration by comparison with existing external gravity field information and error assessment. The temporal gravity gradient corrections consist of tidal and nontidal corrections. These are all generally below the gravity gradient error level, which is predicted to show a 1/ f behaviour for low frequencies. In the outlier detection, the 1/ f error is compensated for by subtracting a local median from the data, while the data error is assessed using the median absolute deviation. The local median acts as a high-pass filter and it is robust as is the median absolute deviation. Three different methods have been implemented for the calibration of the gravity gradients. All three methods use a high-pass filter to compensate for the 1/ f gravity gradient error. The baseline method uses state-of-the-art global gravity field models and the most accurate results are obtained if star sensor misalignments are estimated along with the calibration parameters. A second calibration method uses GOCE GPS data to estimate a low-degree gravity field model as well as gravity gradient scale factors. Both methods allow to estimate gravity gradient scale factors down to the 10-3 level. The third calibration method uses high accurate terrestrial gravity data in selected regions to validate the gravity gradient scale factors, focussing on the measurement band. Gravity gradient scale factors may be estimated down to the 10-2 level with this

  16. Science highlights from high-sensitivity pulsar observations with the MWA

    NASA Astrophysics Data System (ADS)

    McSweeney, Samuel; Bhat, Ramesh; Tremblay, Steven; Ord, Stephen

    2016-01-01

    Pulsars are exquisite probes of the turbulent interstellar medium (ISM), capable of resolving structures down to tens of thousands of kilometres. Understanding the ISM is important for many areas of astrophysics, such as galactic dynamics, the chemical evolution of the galaxy, and the identification of timing noise in the search for gravitational waves using pulsar timing arrays. Low frequency observations of pulsars are key, because the strength of propagation effects scales strongly with frequency.We present the Murchison Widefield Array (MWA) as a key science tool for making high quality observations of pulsars at low frequencies (~80-300 MHz). Recently commissioned software for making tied-array beams and the MWA's high time resolution voltage capture system (VCS) allow an order of magnitude increase in sensitivity, vital for pulsar and other time-domain science. A pipeline has now been developed for observing the scintillation patterns of important pulsars at low frequencies, including a new computational technique for measuring the curvature of parabolic arcs in noisy secondary spectra. A program of MWA observations is being undertaken to sample a large number of millisecond pulsars. We present recent highlights including PSR J0437-4715, which yielded a new measurement of scattering screen distance of ~120 pc from Earth, consistent with a Parkes observation at ~730 MHz, and matching the predicted perimeter of the Local Bubble.

  17. Variable input observer for state estimation of high-rate dynamics

    NASA Astrophysics Data System (ADS)

    Hong, Jonathan; Cao, Liang; Laflamme, Simon; Dodson, Jacob

    2017-04-01

    High-rate systems operating in the 10 μs to 10 ms timescale are likely to experience damaging effects due to rapid environmental changes (e.g., turbulence, ballistic impact). Some of these systems could benefit from real-time state estimation to enable their full potential. Examples of such systems include blast mitigation strategies, automotive airbag technologies, and hypersonic vehicles. Particular challenges in high-rate state estimation include: 1) complex time varying nonlinearities of system (e.g. noise, uncertainty, and disturbance); 2) rapid environmental changes; 3) requirement of high convergence rate. Here, we propose using a Variable Input Observer (VIO) concept to vary the input space as the event unfolds. When systems experience high-rate dynamics, rapid changes in the system occur. To investigate the VIO's potential, a VIO-based neuro-observer is constructed and studied using experimental data collected from a laboratory impact test. Results demonstrate that the input space is unique to different impact conditions, and that adjusting the input space throughout the dynamic event produces better estimations than using a traditional fixed input space strategy.

  18. Examining global extreme sea level variations on the coast from in-situ and remote observations

    NASA Astrophysics Data System (ADS)

    Menendez, Melisa; Benkler, Anna S.

    2017-04-01

    The estimation of extreme water level values on the coast is a requirement for a wide range of engineering and coastal management applications. In addition, climate variations of extreme sea levels on the coastal area result from a complex interacting of oceanic, atmospheric and terrestrial processes across a wide range of spatial and temporal scales. In this study, variations of extreme sea level return values are investigated from two available sources of information: in-situ tide-gauge records and satellite altimetry data. Long time series of sea level from tide-gauge records are the most valuable observations since they directly measure water level in a specific coastal location. They have however a number of sources of in-homogeneities that may affect the climate description of extremes when this data source is used. Among others, the presence of gaps, historical time in-homogeneities and jumps in the mean sea level signal are factors that can provide uncertainty in the characterization of the extreme sea level behaviour. Moreover, long records from tide-gauges are sparse and there are many coastal areas worldwide without in-situ available information. On the other hand, with the accumulating altimeter records of several satellite missions from the 1990s, approaching 25 recorded years at the time of writing, it is becoming possible the analysis of extreme sea level events from this data source. Aside the well-known issue of altimeter measurements very close to the coast (mainly due to corruption by land, wet troposphere path delay errors and local tide effects on the coastal area), there are other aspects that have to be considered when sea surface height values estimated from satellite are going to be used in a statistical extreme model, such as the use of a multi-mission product to get long observed periods and the selection of the maxima sample, since altimeter observations do not provide values uniform in time and space. Here, we have compared the extreme

  19. High Resolution Observations of Escaping Ions in the Martian Magnetotail

    NASA Astrophysics Data System (ADS)

    Halekas, J. S.; Raman, C.; Brain, D.; DiBraccio, G. A.; Harada, Y.; McFadden, J. P.; Mitchell, D. L.; Connerney, J. E. P.; Jakosky, B. M.

    2016-12-01

    Ions escape from the Martian upper atmosphere via a number of channels, including the central plasmasheet of the magnetotail. Mars Express observations show that the heavy ions O+ and O2+ escaping through the central tail often have approximately the same energy, suggesting acceleration in a quasi-static electric field, which has been interpreted as a Hall electric field. The Solar Wind Ion Analyzer (SWIA) on MAVEN was designed to measure the upstream solar wind. However, during orbit segments with appropriate spacecraft attitude, SWIA can also make high resolution measurements of escaping ions in the tail. During the prime mission, these observations were only returned sporadically, during periods of intense escaping fluxes that fortuitously triggered a mode switch. Now, in the extended mission, we return high resolution observations from SWIA routinely. Some of these high resolution measurements reveal slight differences in both the direction and energy of escaping O+ and O2+ ions, which may help determine the acceleration process(es). We investigate the location and solar wind conditions for which the escaping ions separate in energy and angle and the systematics of their energies and flow vectors, and discuss the implications for ion acceleration and the overall picture of Martian atmospheric escape.

  20. Observations of Absorption Lines from Highly Ionized Atoms

    NASA Technical Reports Server (NTRS)

    Jenkins, E. B.

    1984-01-01

    In the ultraviolet spectra of hot stars, absorption lines can be seen from highly ionized species in the interstellar medium. Observations of these features which have been very influential in revising the perception of the medium's various physical states, are discussed. The pervasiveness of O 6 absorption lines, coupled with complementary observations of a diffuse background in soft X-rays and EUV radiation, shows that there is an extensive network of low density gas (n approx. fewX 0.001/cucm) existing at coronal temperatures, 5.3 or = log T or = 6.3. Shocks created by supernova explosions or mass loss from early-type stars can propagate freely through space and eventually transfer a large amount of energy to the medium. To create the coronal temperatures, the shocks must have velocities in excess of 150 km/sec; shocks at somewhat lower velocity 9v or = 100 km/sec) can be directly observed in the lines of Si3. Observations of other lines in the ultraviolet, such as Si 4V and C 5, may highlight the widespread presence of energetic uv radiation from very hot, dward stars. More advanced techniques in visible and X-ray astronomical spectroscopy may open up for inspection selected lines from atoms in much higher stages of ionization.

  1. Fast low-level light pulses from the night sky observed with the SKYFLASH program

    NASA Astrophysics Data System (ADS)

    Winckler, J. R.; Franz, R. C.; Nemzek, R. J.

    1993-05-01

    This paper presents further discussion of and new data on fast subvisual increases in the luminosity of the night sky described in our previous papers. A detailed technical description of the simple telescopic photometers used in the project SKYFLASH and their mode of operation including the detection of polarized Rayleigh-scattered flashes is provided. Distant lightning storms account for many of the events, and the complex relations between short and long luminous pulses with and without sferics are shown by examples from a new computerized data system, supplemented by two low-light-level TV cameras. Of particular interest are the previously observed 'long' events having a slow rise and fall, 20-ms duration, and showing small polarization and no coincident sferic. A group of such events on September 22-23 during the invasion of U.S. coasts by Hurricane Hugo, is discussed in detail. The recently observed 'plume' cloud-top-to-stratosphere lightning event is suggested as a possible source type for these flashes. An alternative source may be exploding meteors, recently identified during SKYFLASH observations by low-light-level television techniques as the origin of some sky-wide flash events described herein.

  2. Fast low-level light pulses from the night sky observed with the SKYFLASH program

    NASA Technical Reports Server (NTRS)

    Winckler, J. R.; Franz, R. C.; Nemzek, R. J.

    1993-01-01

    This paper presents further discussion of and new data on fast subvisual increases in the luminosity of the night sky described in our previous papers. A detailed technical description of the simple telescopic photometers used in the project SKYFLASH and their mode of operation including the detection of polarized Rayleigh-scattered flashes is provided. Distant lightning storms account for many of the events, and the complex relations between short and long luminous pulses with and without sferics are shown by examples from a new computerized data system, supplemented by two low-light-level TV cameras. Of particular interest are the previously observed 'long' events having a slow rise and fall, 20-ms duration, and showing small polarization and no coincident sferic. A group of such events on September 22-23 during the invasion of U.S. coasts by Hurricane Hugo, is discussed in detail. The recently observed 'plume' cloud-top-to-stratosphere lightning event is suggested as a possible source type for these flashes. An alternative source may be exploding meteors, recently identified during SKYFLASH observations by low-light-level television techniques as the origin of some sky-wide flash events described herein.

  3. Hip Arthroscopy in High-Level Baseball Players.

    PubMed

    Byrd, J W Thomas; Jones, Kay S

    2015-08-01

    To report the results of hip arthroscopy among high-level baseball players as recorded by outcome scores and return to baseball. All patients undergoing hip arthroscopy were prospectively assessed with the modified Harris Hip Score. On review of all procedures performed over a 12-year period, 44 hips were identified among 41 intercollegiate or professional baseball players who had achieved 2-year follow-up. Among the 41 players, follow-up averaged 45 months (range, 24 to 120 months), with a mean age of 23 years (range, 18 to 34 years). There were 23 collegiate (1 bilateral) and 18 professional (2 bilateral) baseball players, including 10 Major League Baseball players. Of the 8 Major League Baseball pitchers, 6 (75%) also underwent ulnar collateral ligament elbow surgery. Improvement in the modified Harris Hip Score averaged 13 points (from 81 points preoperatively to 94 points postoperatively); a paired-samples t test determined that this mean improvement of 13 points was statistically significant (P < .001). Players returned to baseball after 42 of 44 procedures (95%) at a mean of 4.3 months (range, 3 to 8 months), with 90% regaining the ability to participate at their previous level of competition. There were no complications. Three players (1 bilateral) underwent repeat arthroscopy. This study supports the idea that arthroscopic treatment for a variety of hip pathologies in high-level baseball players provides a successful return to sport and improvement in functional outcome scores. Level IV, therapeutic case series. Copyright © 2015 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

  4. How Non-Linearity and Grade-Level Differences Complicate the Validation of Observation Protocols

    ERIC Educational Resources Information Center

    Lazarev, Valeriy; Newman, Denis

    2013-01-01

    Teacher evaluation is currently a major policy issue at all levels of the K-12 system driven in large part by current US Department of Education requirements. The main objective of this study is to explore the patterns of relationship between observational scores and value-added measures of teacher performance in math classrooms and the variation…

  5. Solar flare microwave observations with high spectral resolution

    NASA Astrophysics Data System (ADS)

    Bruggmann, G.; Magun, A.; Benz, A. O.; Stehling, W.

    1990-12-01

    The solar flare radio emission in the 6-8 GHz range was observed with a high resolution spectrometer. The observed band corresponds to the plasma frequencies and gyrofrequencies of the transition region and the lowest part of the corona in active regions. Most of the emissions were found to be broadbanded, as expected from the gyrosynchrotron mechanism. In eight out of 46 observed events, spectral structures of three types were detected: spikes below the time resolution of 100 ms, slowly drifting broadband structures, and a narrow bandwidth patch of continuum emission. These first narrowband bursts spectrally recorded in the 6-8 GHz range are generally weak. Slowly drifting structures are the only type compatible with the gyrosynchrotron emission mechanism. A simple argument based on free-free absorption shows that plasma emission can only be propagated if the radiation originates in a dense region with a small density-scale length. The same holds for maser emission at a low harmonic of the electron gyrofrequency. Possible emission mechanisms and diagnostic capabilities are discussed.

  6. Intense sub-kilometer-scale boundary layer rolls observed in hurricane fran

    PubMed

    Wurman; Winslow

    1998-04-24

    High-resolution observations obtained with the Doppler On Wheels (DOW) mobile weather radar near the point of landfall of hurricane Fran (1996) revealed the existence of intense, sub-kilometer-scale, boundary layer rolls that strongly modulated the near-surface wind speed. It is proposed that these structures are one cause of geographically varying surface damage patterns that have been observed after some landfalling hurricanes and that they cause much of the observed gustiness, bringing high-velocity air from aloft to the lowest observable levels. High-resolution DOW radar observations are contrasted with lower-resolution observations obtained with an operational weather radar, which underestimated peak low-level wind speeds.

  7. X-Ray Observations of High-Energy Pulsars: PSR B1951+32 and Geminga

    NASA Astrophysics Data System (ADS)

    Ho, Cheng

    Observations at frequencies across a wide range of electromagnetic spectra are key to the understanding of the origin and mechanisms of high-energy emissions from pulsars. We propose to observe the high-energy pulsars PSR B1951+32 and Geminga with XTE. These two sources emit X-rays at low enough count rate that we can acquire high resolution timing and spectral data, allowing us to perform detailed analysis on the ground. Staring integration of 10 ksec for each source is requested. Data obtained in these observations, together with those from ROSAT, GRO and a planned project for optical counterpart study at Los Alamos, will provide crucial information to advance high-energy pulsar research.

  8. Variation in airborne 137Cs peak levels with altitude from high-altitude locations across Europe after the arrival of Fukushima-labeled air masses

    NASA Astrophysics Data System (ADS)

    Masson, Olivier; Bieringer, Jacqueline; Dalheimer, Axel; Estier, Sybille; Evrard, Olivier; Penev, Ilia; Ringer, Wolfgang; Schlosser, Clemens; Steinkopff, Thomas; Tositti, Laura; de Vismes-Ott, Anne

    2015-04-01

    During the Fukushima Daiichi nuclear power plant (FDNPP) accident, a dozen of high-altitude aerosol sampling stations, located between 850 and 3,454 m above sea level (a.s.l.), provided airborne activity levels across Europe (Fig. 1). This represents at most 5% of the total number of aerosol sampling locations that delivered airborne activity levels (at least one result) in Europe, in connection with this nuclear accident. High altitude stations are typically equipped with a high volume sampler that collects aerosols on filters. The Fukushima-labeled air mass arrival and the peak of airborne cesium-137 (137Cs) activity levels were registered in Europe at different dates depending on the location, with differences up to a factor of six on a regional scale. Besides this statement related to lowland areas, we have compared the maximum airborne levels registered at high-altitude European locations (850 m < altitudes < 3450 m) with what was observed at the closest lowland location. The vertical distribution of 137Cs peak level was not uniform even after a long travel time/distance from Japan. This being true at least in the atmospheric boundary layer and in the lower free troposphere. Moreover the relation '137Csmax vs. altitude' shows a decreasing trend (Fig. 2). Results and discussion : Comparison of 137Cs and 7Be levels shows simultaneous increases at least when the 137Cs airborne level rose for the first time (Fig. 3). Zugspitze and Jungfraujoch stations attest of a time shift between 7Be and 137Cs peak that can be due to the particular dynamic of air movements at such high altitudes. After the 137Cs peak value, the plume concentration decreased whatever the 7Be level. Due to the cosmogenic origin of 7Be, its increase in the ground-level air is usually associated with downwind air movements, i.e. stratospheric air intrusions or at least air from high-tropospheric levels, into lower atmospheric layers. This means that Fukushima-labeled air masses registered at ground

  9. High-Resolution Observations of a Meteo-Tsunami

    NASA Astrophysics Data System (ADS)

    Assink, J. D.; Evers, L. G.; Smink, M.; Apituley, A.

    2017-12-01

    In the early morning of 29 May 2017, unusually large waves of over 2 m height hit the west coast of the Netherlands, leading to some property damage. The waves were due to a meteo-tsunami, which is a tsunami of meteorological origin, unlike seismogenic tsunamis. This particular event was caused by a rapidly moving cold front which featured a sharp squall line that moved towards the coast. Associated was a large perturbation in air pressure of 5 hPa which, along with Proudman resonance effects and the upsloping seabottom lead to the tidal surge. While the meteorological conditions leading up to such an event are relatively common, the more extreme events appear to happen under specific conditions only. As a result of the meteo-tsunami, gravity waves were observed all over the Netherlands with a variety of meteorlogical instruments, including weather radar, ceilometers and a network of microbarometers that are typically used for the detection of infrasound. In this presentation, these high-resolution observations of gravity waves are compared with mesoscale weather models.

  10. Optical observation of metal jet generated by high speed inclined collision

    NASA Astrophysics Data System (ADS)

    Mori, A.; Tanaka, S.; Hokamoto, K.

    2017-02-01

    Explosive welding, one of the high energy rate material processing, is known the technique to weld strongly for the dissimilar metal combinations. When a metal is collided to the other metal at high velocity with a certain angle, good welding is achieved in this technique. Important parameters of the explosive welding method are the collision velocity and the collision angle. And it is necessary to know these parameters to obtain the explosively welded materials of several metals combinations. However, the optical observation for the collision of metal plate accelerated by the explosive is difficult because of the obstruction by the spreading of detonation gas. In the present work a single-stage powder gun and high speed video camera were used to observe the inclined collision of metals at the high velocity. Projectile consisted by a metal disc and sabot was accelerated by the deflagration of a gunpowder and was collided to another metal disc set with a certain angle. Metal jet was generated at the collision point when the projectile was collided to the target disc in the range of suitable conditions. By using this observation system, a series of the flow from the high speed collision to the generation of metal jet could be taken photographs clearly. This investigation shows the experimental results of the similar and dissimilar metal collision, with comparing the visualization of a metal jet simulated numerically.

  11. An Observational Study of the Relationship between Cloud, Aerosol and Meteorology in Broken Low-Level Cloud Conditions

    NASA Technical Reports Server (NTRS)

    Loeb, Norman G.; Schuster, Gregory L.

    2008-01-01

    Global satellite analyses showing strong correlations between aerosol optical depth and 3 cloud cover have stirred much debate recently. While it is tempting to interpret the results as evidence of aerosol enhancement of cloud cover, other factors such as the influence of meteorology on both the aerosol and cloud distributions can also play a role, as both aerosols and clouds depend upon local meteorology. This study uses satellite observations to examine aerosol-cloud relationships for broken low-level cloud regions off the coast of Africa. The analysis approach minimizes the influence of large-scale meteorology by restricting the spatial and temporal domains in which the aerosol and cloud properties are compared. While distributions of several meteorological variables within 5deg 5deg latitude-longitude regions are nearly identical under low and high aerosol optical depth, the corresponding distributions of single-layer low cloud properties and top-of-atmosphere radiative fluxes differ markedly, consistent with earlier studies showing increased cloud cover with aerosol optical depth. Furthermore, fine-mode fraction and Angstrom Exponent are also larger in conditions of higher aerosol optical depth, even though no evidence of systematic latitudinal or longitudinal gradients between the low and high aerosol optical depth populations are observed. When the analysis is repeated for all 5deg 5deg latitude-longitude regions over the global oceans (after removing cases in which significant meteorological differences are found between the low and high aerosol populations), results are qualitatively similar to those off the coast of Africa.

  12. Effect of high-fat intake on motor activity, homovanillic acid and 5-hydroxyindoleacetic acid levels in striatum and cortex of rats exposed to stress.

    PubMed

    Kirac, Deniz; Ozden, Inci; Yildirim, Alper; Genç, Ece

    2009-04-01

    The aim of the present study was to investigate whether high fat consumption changes the effects of stress on both motor activity performance, striatal and cortical dopamine and serotonin metabolites in rats. The animals were fed either with high fat or standard diet for 4 weeks. Restraint stress lasting for 15 min at +4 degrees C was applied daily to stress-exposed groups. Motor activity performance was measured weekly by using motor activity monitoring systems. At the end of the study, homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) levels of the striatum and cerebral cortex were measured by HPLCEC. It was observed that restraint stress increased locomotor activity and high-fat diet prevented this effect. Stress and high-fat intake had an additive decreasing effect on striatal HVA levels. 5-HIAA levels, on the other hand, were lower in both high fat and high fat + stress groups compared to the stress group. These results suggest that high-fat intake differentially affected the stress response on striatal dopaminergic and serotonergic neurons in rat brain regions studied and this may be related to the effects observed in motor activity performance.

  13. Natural geochemical analogues of the near field of high-level nuclear waste repositories

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Apps, J.A.

    1995-09-01

    United States practice has been to design high-level nuclear waste (HLW) geological repositories with waste densities sufficiently high that repository temperatures surrounding the waste will exceed 100{degrees}C and could reach 250{degrees}C. Basalt and devitrified vitroclastic tuff are among the host rocks considered for waste emplacement. Near-field repository thermal behavior and chemical alteration in such rocks is expected to be similar to that observed in many geothermal systems. Therefore, the predictive modeling required for performance assessment studies of the near field could be validated and calibrated using geothermal systems as natural analogues. Examples are given which demonstrate the need for refinementmore » of the thermodynamic databases used in geochemical modeling of near-field natural analogues and the extent to which present models can predict conditions in geothermal fields.« less

  14. Variable input observer for structural health monitoring of high-rate systems

    NASA Astrophysics Data System (ADS)

    Hong, Jonathan; Laflamme, Simon; Cao, Liang; Dodson, Jacob

    2017-02-01

    The development of high-rate structural health monitoring methods is intended to provide damage detection on timescales of 10 µs -10ms where speed of detection is critical to maintain structural integrity. Here, a novel Variable Input Observer (VIO) coupled with an adaptive observer is proposed as a potential solution for complex high-rate problems. The VIO is designed to adapt its input space based on real-time identification of the system's essential dynamics. By selecting appropriate time-delayed coordinates defined by both a time delay and an embedding dimension, the proper input space is chosen which allows more accurate estimations of the current state and a reduction of the convergence rate. The optimal time-delay is estimated based on mutual information, and the embedding dimension is based on false nearest neighbors. A simulation of the VIO is conducted on a two degree-of-freedom system with simulated damage. Results are compared with an adaptive Luenberger observer, a fixed time-delay observer, and a Kalman Filter. Under its preliminary design, the VIO converges significantly faster than the Luenberger and fixed observer. It performed similarly to the Kalman Filter in terms of convergence, but with greater accuracy.

  15. Ultrasonic level sensors for liquids under high pressure

    NASA Technical Reports Server (NTRS)

    Zuckerwar, A. J.; Mazel, D. S.; Hodges, D. Y.

    1986-01-01

    An ultrasonic level sensor of novel design continuously measures the level of a liquid subjected to a high pressure (up to about 40 MPa), as is sometimes required for the effective transfer of the liquid. The sensor operates as a composite resonator fabricated from a standard high-pressure plug. A flat-bottom hole is machined into the plug along its center line. An ultrasonic transducer is bonded rigidly to the interior surface of the bottom wall, while the exterior surface is in contact with the liquid. Although the bottom wall is designed to satisfy the pressure code, it is still sufficiently thin to permit ready excitation of the axisymmetric plate modes of vibration. The liquid level is measured by a conventional pulse-echo technique. A prototype sensor was tested successfully in a 2300-l water vessel at pressures up to about 37 MPa. A spectral analysis of the transmitted pulse reveals that the flexural, extensional, thickness-shear, and radial plate modes are excited into vibration, but none of these appears to be significantly affected by the pressurization of the liquid.

  16. Very high resolution observations of SS433 at 10.65 GHz

    NASA Technical Reports Server (NTRS)

    Geldzahler, B. J.; Downes, A. J. B.; Shaffer, D. B.

    1981-01-01

    Observations of SS433 made on June 12, 1979, from West Germany, Massachusetts, and West Virginia are discussed. It is noted that SS433 did not show fringes on any baseline although all the calibration sources were seen at their expected strengths. The measured total flux density of SS433 was found to be approximately 0.5 Jy, consistent with previous observations. The source was observed by on-offs at each telescope, which indicates that they were all pointed properly during the observations. The absence of fringes is not attributed to poor observing conditions or instrumental difficulties. It is concluded that if all the 10.65 GHz radiation emanates from a single component, then that component is at least 0.005 arcsec (approximately 10 to the 14th cm) in size. The measurements made on more sensitive intercontinental baselines indicate that there is no component of SS433 smaller than 0.001 arcsec emitting 10.65 GHz radiation above a level of 50 mJy.

  17. Cloning and establishment of a line of rats for high levels of voluntary wheel running.

    PubMed

    Morishima-Yamato, Masaki; Hisaoka, Fumiko; Shinomiya, Sachiko; Harada, Nagakatsu; Matoba, Hideki; Takahashi, Akira; Nakaya, Yutaka

    2005-06-17

    We generated an original Wistar line of rats that displayed increased levels of wheel running, which we named SPORTS (Spontaneously-Running-Tokushima-Shikoku). Male SPORTS rats ran voluntarily in a running wheel almost six times longer than male control Wistar rats, established without selection for their running activity. The running phenotype of female SPORTS rats was the same as female control Wistar rats. However, male offspring from the cross-mating between a female SPORTS rat and a male control rat also showed a similar level of hyper-running activity as the original SPORTS line. Compared to control rats, male SPORTS rats had lower levels of mean body weight, abdominal fat and plasma insulin after 4 weeks of running. It is likely that all these beneficial changes observed in the SPORTS rats reflected the increases in glucose disposal we observed in oral glucose tolerance tests carried out on the animals. We also found hyper-running caused a significant increase in skeletal muscle oxidative capacity, measured as the ratio of malate dehydrogenase to phosphofructokinase activity, an index of aerobic metabolism. These results indicate that the SPORTS rat may be a good animal model for determining the mechanisms responsible for up-regulation of running motivation, in addition to investigating changes in nutrient metabolism induced by high intensity exercise.

  18. Exploring students' perceptions and performance on predict-observe-explain tasks in high school chemistry laboratory

    NASA Astrophysics Data System (ADS)

    Vadapally, Praveen

    This study sought to understand the impact of gender and reasoning level on students' perceptions and performances of Predict-Observe-Explain (POE) laboratory tasks in a high school chemistry laboratory. Several literature reviews have reported that students at all levels have not developed the specific knowledge and skills that were expected from their laboratory work. Studies conducted over the last several decades have found that boys tend to be more successful than girls in science and mathematics courses. However, some recent studies have suggested that girls may be reducing this gender gap. This gender difference is the focal point of this research study, which was conducted at a mid-western, rural high school. The participants were 24 boys and 25 girls enrolled in two physical science classes taught by the same teacher. In this mixed methods study, qualitative and quantitative methods were implemented simultaneously over the entire period of the study. MANOVA statistics revealed significant effects due to gender and level of reasoning on the outcome variables, which were POE performances and perceptions of the chemistry laboratory environment. There were no significant interactions between these effects. For the qualitative method, IRB-approved information was collected, coded, grouped, and analyzed. This method was used to derive themes from students' responses on questionnaires and semi-structured interviews. Students with different levels of reasoning and gender were interviewed, and many of them expressed positive themes, which was a clear indication that they had enjoyed participating in the POE learning tasks and they had developed positive perceptions towards POE inquiry laboratory learning environment. When students are capable of formal reasoning, they can use an abstract scientific concept effectively and then relate it to the ideas they generate in their minds. Thus, instructors should factor the nature of students' thinking abilities into their

  19. High-cadence, High-resolution Spectroscopic Observations of Herbig Stars HD 98922 and V1295 Aquila

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aarnio, Alicia N.; Monnier, John D.; Calvet, Nuria

    Recent observational work has indicated that mechanisms for accretion and outflow in Herbig Ae/Be star–disk systems may differ from magnetospheric accretion (MA) as it is thought to occur in T Tauri star–disk systems. In this work, we assess the temporal evolution of spectral lines probing accretion and mass loss in Herbig Ae/Be systems and test for consistency with the MA paradigm. For two Herbig Ae/Be stars, HD 98922 (B9e) and V1295 Aql (A2e), we have gathered multi-epoch (∼years) and high-cadence (∼minutes) high-resolution optical spectra to probe a wide range of kinematic processes. Employing a line equivalent width evolution correlation metricmore » introduced here, we identify species co-evolving (indicative of common line origin) via novel visualization. We interferometrically constrain often problematically degenerate parameters, inclination and inner-disk radius, allowing us to focus on the structure of the wind, magnetosphere, and inner gaseous disk in radiative transfer models. Over all timescales sampled, the strongest variability occurs within the blueshifted absorption components of the Balmer series lines; the strength of variability increases with the cadence of the observations. Finally, high-resolution spectra allow us to probe substructure within the Balmer series’ blueshifted absorption components: we observe static, low-velocity features and time-evolving features at higher velocities. Overall, we find the observed line morphologies and variability are inconsistent with a scaled-up T Tauri MA scenario. We suggest that as magnetic field structure and strength change dramatically with increasing stellar mass from T Tauri to Herbig Ae/Be stars, so too may accretion and outflow processes.« less

  20. Low-mass ions observed in plasma desorption mass spectrometry of high explosives

    PubMed

    Hakansson; Coorey; Zubarev; Talrose; Hakansson

    2000-03-01

    The low-mass ions observed in both positive and negative plasma desorption mass spectrometry (PDMS) of the high explosives HMX, RDX, CL-20, NC, PETN and TNT are reported. Possible identities of the most abundant ions are suggested and their presence or absence in the different spectra is related to the properties of the explosives as matrices in PDMS. The detection of abundant NO+ and NO2- ions for HMX, RDX and CL-20, which are efficient matrices, indicates that explosive decomposition takes place in PDMS of these three substances and that a contribution from the corresponding chemical energy release is possible. The observation of abundant C2H4N+ and CH2N+ ions, which have high protonation properties, might also explain the higher protein charge states observed with these matrices. Also, the observation of NO2-, possibly formed by electron scavenging which increases the survival probability of positively charged protein molecular ions, completes the pattern. TNT does not give any of these ions and it is thereby possible to explain why it does not work as a PDMS matrix. For NC and PETN, decomposition does not seem to be as pronounced as for HMX, RDX and CL-20, and also no particularly abundant ions with high protonation properties are observed. The fact that NC works well as a matrix might be related to other properties of this compound, such as its high adsorption ability.

  1. Differential Response to Exercise in African Americans with High Levels of Inflammation.

    PubMed

    Kretzschmar, Jan; Babbitt, Dianne M; Diaz, Keith M; Feairheller, Deborah L; Sturgeon, Kathleen M; Perkins-Ball, Amanda M; Williamson, Sheara T; Ling, Chenyi; Grimm, Heather; Brown, Michael D

    2017-01-01

    Systemic inflammation, measured by C-reactive protein (CRP), is an important risk factor for cardiovascular disease (CVD) and mortality. We investigated whether aerobic exercise training (AEXT) affects African Americans with high inflammation (HI) the same way it does African Americans with low inflammation (LI) in terms of CVD risk factors. 23 African Americans with CRP levels <3 mg/L (LI) and 14 African Americans with CRP ≥3 mg/L (HI) underwent six months of AEXT. Participants were sedentary, non-diabetic, non-smoking, with clinical blood pressure <160/100 mm Hg, were non-hyperlipidemic, had no signs of cardiovascular, renal, or pulmonary disease, and were not on medication. Measures included CD62E+ endothelial microparticles (EMPs), a measure of early stage endothelial dysfunction, as well as lipid and glucose profile, aerobic fitness, body composition, and blood pressure. The LI group improved aerobic fitness by 10%, body mass index by 3%, and plasma triglycerides by 20%, with no change being observed in HI group for these variables. The HI group improved fasting plasma glucose levels by 10%, with no change occurring in the LI group. Both groups improved CD62E+ EMPs by 38% and 59% for the LI and HI group, respectively. A standard AEXT intervention differentially affected CVD risk factors among African Americans with high and low inflammation. This may indicate that, in African Americans with high inflammation, AEXT alone may not be enough to reap the same benefits as their low-inflammation peers in terms of CVD risk modification.

  2. Top-Down CO Emissions Based On IASI Observations and Hemispheric Constraints on OH Levels

    NASA Astrophysics Data System (ADS)

    Müller, J.-F.; Stavrakou, T.; Bauwens, M.; George, M.; Hurtmans, D.; Coheur, P.-F.; Clerbaux, C.; Sweeney, C.

    2018-02-01

    Assessments of carbon monoxide emissions through inverse modeling are dependent on the modeled abundance of the hydroxyl radical (OH) which controls both the primary sink of CO and its photochemical source through hydrocarbon oxidation. However, most chemistry transport models (CTMs) fall short of reproducing constraints on hemispherically averaged OH levels derived from methylchloroform (MCF) observations. Here we construct five different OH fields compatible with MCF-based analyses, and we prescribe those fields in a global CTM to infer CO fluxes based on Infrared Atmospheric Sounding Interferometer (IASI) CO columns. Each OH field leads to a different set of optimized emissions. Comparisons with independent data (surface, ground-based remotely sensed, aircraft) indicate that the inversion adopting the lowest average OH level in the Northern Hemisphere (7.8 × 105 molec cm-3, ˜18% lower than the best estimate based on MCF measurements) provides the best overall agreement with all tested observation data sets.

  3. Water-level changes in the High Plains aquifer; predevelopment to 1991

    USGS Publications Warehouse

    McGrath, T.J.; Dugan, J.T.

    1993-01-01

    Regional variability in water-level change in the High Plains aquifer underlying parts of Colorado, Kansas, Nebraska, New Mexico, Oklahoma, South Dakota, Texas, and Wyoming results from large regional differences in climate, soils, land use, and ground-water withdrawals for irrigation. From the beginning of significant development of the High Plains aquifer for irrigation to 1980, substantial water-level declines have occurred in several areas. The estimated average area-weighted water-level decline from predevelopment to 1980 for the High Plains was 9.9 feet, an average annual decline of about 0.25 foot. These declines exceeded 100 feet in some parts of the Central and Southern High Plains. Declines were much smaller and less extensive in the Northern High Plains as a result of later irrigation development. Since 1980, water levels in those areas of large declines in the Central and Southern High Plains have continued to decline, but at a much slower annual rate. The estimated average area-weighted water-level decline from 1980 to 1991 for the entire High Plains was 1.41 feet, an average annual decline of about 0.13 foot. The relatively small decline since 1980, in relation to the declines prior to 1980, is associated with a decrease in ground-water application for irrigated agriculture and greater than normal precipitation. Water-conserving practices and technology, in addition to reductions in irrigated acreages, contributed to the decrease in ground-water withdrawals for irrigation.

  4. The TETRA-II Experiment to Observe Terrestrial Gamma Flashes at Ground Level - Preliminary Results

    NASA Astrophysics Data System (ADS)

    Cherry, M. L.; Adams, C.; Al-Nussirat, S.; Bai, S.; Banadaki, Y.; Bitzer, P. M.; Hoffmann, J.; Khosravi, E.; Legault, M.; Orang, M.; Pleshinger, D. J.; Rodriguez, R.; Smith, D.; Trepanier, J. C.; Sunda-Meya, A.; Zimmer, N.

    2017-12-01

    An upgraded version of the TGF and Energetic Thunderstorm Rooftop Array (TETRA-II) consists of an array of BGO scintillators to detect bursts of gamma rays from thunderstorms at ground level in four separate locations: the campus of Louisiana State University in Baton Rouge, Louisiana; the campus of the University of Puerto Rico at Utuado, Puerto Rico; the Centro Nacional de Metrologia de Panama (CENAMEP) in Panama City, Panama; and the Severe Weather Institute and Radar & Lightning Laboratories in Huntsville, Alabama. The original TETRA-I array of NaI scintillators at Louisiana State University detected 37 millisecond-scale bursts of gamma rays at energies 50 keV-2 MeV associated with nearby (< 8 km) thunderstorms. TETRA-II began operation in May 2016 and now has approximately an order of magnitude greater sensitivity than TETRA-I. The ability to observe ground-level Terrestrial Gamma Flashes from close to the source allows a unique analysis of the storm cells producing these events. A brief description of the TETRA-I observations, a description of TETRA-II, and preliminary results of the first events observed by TETRA-II will be presented including frequency and time history of events, spectral information, and correlation with local radar and radio data.

  5. Professional Staffing Levels and Fourth-Grade Student Research in Rural Schools with High-Poverty Levels

    ERIC Educational Resources Information Center

    Krueger, Karla Steege; Donham, Jean

    2013-01-01

    Rural schools in high-poverty areas are often understaffed. This descriptive phenomenological study examined fourth-grade state research projects in high-poverty rural Iowa schools to reveal the influence of school librarians' staffing levels on student learning of research skills. To determine evidence of students' critical literacy, ethical use…

  6. Building Level Administrators' Attitudes toward Teacher Effectiveness at the High School and Middle School Levels

    ERIC Educational Resources Information Center

    Hanson, Nathan K.

    2010-01-01

    This study investigated the attitudes of administrators about differences and similarities between middle and high school teachers. The research question that guided the study was, "Do attitudes about what makes an effective educator differ between building administrators at the middle and high school levels?" A formal, sequential, mixed-methods…

  7. The Response to High CO2 Levels Requires the Neuropeptide Secretion Component HID-1 to Promote Pumping Inhibition

    PubMed Central

    Sharabi, Kfir; Charar, Chayki; Friedman, Nurit; Mizrahi, Inbar; Zaslaver, Alon; Sznajder, Jacob I.; Gruenbaum, Yosef

    2014-01-01

    Carbon dioxide (CO2) is a key molecule in many biological processes; however, mechanisms by which organisms sense and respond to high CO2 levels remain largely unknown. Here we report that acute CO2 exposure leads to a rapid cessation in the contraction of the pharynx muscles in Caenorhabditis elegans. To uncover the molecular mechanisms underlying this response, we performed a forward genetic screen and found that hid-1, a key component in neuropeptide signaling, regulates this inhibition in muscle contraction. Surprisingly, we found that this hid-1-mediated pathway is independent of any previously known pathways controlling CO2 avoidance and oxygen sensing. In addition, animals with mutations in unc-31 and egl-21 (neuropeptide secretion and maturation components) show impaired inhibition of muscle contraction following acute exposure to high CO2 levels, in further support of our findings. Interestingly, the observed response in the pharynx muscle requires the BAG neurons, which also mediate CO2 avoidance. This novel hid-1-mediated pathway sheds new light on the physiological effects of high CO2 levels on animals at the organism-wide level. PMID:25101962

  8. In Situ Observation of Gypsum-Anhydrite Transition at High Pressure and High Temperature

    NASA Astrophysics Data System (ADS)

    Liu, Chuan-Jiang; Zheng, Hai-Fei

    2012-04-01

    An in-situ Raman spectroscopic study of gypsum-anhydrite transition under a saturated water condition at high pressure and high temperature is performed using a hydrothermal diamond anvil cell (HDAC). The experimental results show that gypsum dissolvs in water at ambient temperature and above 496 MPa. With increasing temperature, the anhydrite (CaSO4) phase precipitates at 250-320°C in the pressure range of 1.0-1.5GPa, indicating that under a saturated water condition, both stable conditions of pressure and temperature and high levels of Ca and SO4 ion concentrations in aqueous solution are essential for the formation of anhydrite. A linear relationship between the pressure and temperature for the precipitation of anhydrite is established as P(GPa) = 0.0068T-0.7126 (250°C<=T<=320°C). Anhydrite remained stable during rapid cooling of the sample chamber, showing that the gypsum-anhydrite transition involving both dissolution and precipitation processes is irreversible at high pressure and high temperature.

  9. Complex carbon cycle responses to multi-level warming and supplemental summer rain in the high Arctic.

    PubMed

    Sharp, Elizabeth D; Sullivan, Patrick F; Steltzer, Heidi; Csank, Adam Z; Welker, Jeffrey M

    2013-06-01

    The Arctic has experienced rapid warming and, although there are uncertainties, increases in precipitation are projected to accompany future warming. Climate changes are expected to affect magnitudes of gross ecosystem photosynthesis (GEP), ecosystem respiration (ER) and the net ecosystem exchange of CO2 (NEE). Furthermore, ecosystem responses to climate change are likely to be characterized by nonlinearities, thresholds and interactions among system components and the driving variables. These complex interactions increase the difficulty of predicting responses to climate change and necessitate the use of manipulative experiments. In 2003, we established a long-term, multi-level and multi-factor climate change experiment in a polar semidesert in northwest Greenland. Two levels of heating (30 and 60 W m(-2) ) were applied and the higher level was combined with supplemental summer rain. We made plot-level measurements of CO2 exchange, plant community composition, foliar nitrogen concentrations, leaf δ(13) C and NDVI to examine responses to our treatments at ecosystem- and leaf-levels. We confronted simple models of GEP and ER with our data to test hypotheses regarding key drivers of CO2 exchange and to estimate growing season CO2 -C budgets. Low-level warming increased the magnitude of the ecosystem C sink. Meanwhile, high-level warming made the ecosystem a source of C to the atmosphere. When high-level warming was combined with increased summer rain, the ecosystem became a C sink of magnitude similar to that observed under low-level warming. Competition among our ER models revealed the importance of soil moisture as a driving variable, likely through its effects on microbial activity and nutrient cycling. Measurements of community composition and proxies for leaf-level physiology suggest GEP responses largely reflect changes in leaf area of Salix arctica, rather than changes in leaf-level physiology. Our findings indicate that the sign and magnitude of the future

  10. Very high energy gamma ray extension of GRO observations

    NASA Technical Reports Server (NTRS)

    Weekes, Trevor C.

    1992-01-01

    This has been an exiciting year for high energy gamma-ray astronomy, both from space and from ground-based observatories. It has been a particularly active period for the Whipple Observatory gamma-ray group. In phase 1 of the Compton Gamma Ray Observatory (GRO), there has not been too much opportunity for overlapping observations with the Energetic Gamma Ray Experiment Telescope (EGRET) and the other GRO telescopes; however, significant progress was made in the development of data analysis techniques and in improving the sensitivity of the technique which will have direct application in correlative observations in phase 2. Progress made during the period 1 Jul. 1991 - 31 Dec. 1991 is presented.

  11. Observations and operational model simulations reveal the impact of Hurricane Matthew (2016) on the Gulf Stream and coastal sea level

    NASA Astrophysics Data System (ADS)

    Ezer, Tal; Atkinson, Larry P.; Tuleya, Robert

    2017-12-01

    In October 7-9, 2016, Hurricane Matthew moved along the southeastern coast of the U.S., causing major flooding and significant damage, even to locations farther north well away from the storm's winds. Various observations, such as tide gauge data, cable measurements of the Florida Current (FC) transport, satellite altimeter data and high-frequency radar data, were analyzed to evaluate the impact of the storm. The data show a dramatic decline in the FC flow and increased coastal sea level along the U.S. coast. Weakening of the Gulf Stream (GS) downstream from the storm's area contributed to high coastal sea levels farther north. Analyses of simulations of an operational hurricane-ocean coupled model reveal the disruption that the hurricane caused to the GS flow, including a decline in transport of ∼20 Sv (1 Sv = 106 m3 s-1). In comparison, the observed FC reached a maximum transport of ∼40 Sv before the storm on September 10 and a minimum of ∼20 Sv after the storm on October 12. The hurricane impacts both the geostrophic part of the GS and the wind-driven currents, generating inertial oscillations with velocities of up to ±1 m s-1. Analysis of the observed FC transport since 1982 indicated that the magnitude of the current weakening in October 2016 was quite rare (outside 3 standard deviations from the mean). Such a large FC weakening in the past occurred more often in October and November, but is extremely rare in June-August. Similar impacts on the FC from past tropical storms and hurricanes suggest that storms may contribute to seasonal and interannual variations in the FC. The results also demonstrated the extended range of coastal impacts that remote storms can cause through their influence on ocean currents.

  12. Mass-induced sea level variations in the Red Sea from steric-corrected altimetry, GRACE, in-situ bottom pressure records, and hydrographic observations

    NASA Astrophysics Data System (ADS)

    Feng, Wei; Lemoine, Jean-Michel; Zhong, Min; Xu, Houze

    2014-05-01

    An annual amplitude of ~18 cm mass-induced sea level variations (SLV) in the Red Sea is detected from steric-corrected altimetry and the Gravity Recovery and Climate Experiment (GRACE) satellites from 2003 to 2011, which dominates the mean sea level in the region. Seawater mass variations here generally reach maximum in late January/early February. The steric component of SLV calculated from oceanographic temperature and salinity data is relatively small and peaks about seven months later than mass variations. The phase difference between the steric SLV and the mass-induced SLV indicates that when the Red Sea gains the mass from inflow water in winter, the steric SLV fall, and vice versa in summer. In-situ bottom pressure records in the eastern coast of the Red Sea validate the high mass variability observed by steric-corrected altimetry and GRACE. Furthermore, we compare the horizontal water mass flux in the Red Sea from steric-corrected altimetry and GRACE with that estimated from hydrographic observations.

  13. Bone-level implants placed in the anterior maxilla: an open-label, single-arm observational study

    PubMed Central

    2017-01-01

    Purpose This study assessed marginal bone remodeling and soft tissue esthetics after the loading of single bone-level implants in the anterior maxilla. Methods An open, single-arm observational clinical trial with 3 years of follow-up was performed, including 22 implants. The patients presented with a single tooth gap in the anterior maxilla (tooth positions 14–24), with natural or restored adjacent teeth. An implant was placed at least 8 weeks post-extraction and healed submerged for 6 weeks. After the second-stage operation, a fixed provisional prosthesis was provided. The final restoration was placed 6 months after the provisional restoration. The time of the provisional crown connection was considered to be the baseline in this study. Esthetic parameters and the marginal bone level were assessed at 6, 12, 24, and 36 months. Results All implants were well integrated in the bone. A statistically significant increase was found in the mean implant stability quotient between the time of the provisional prosthesis and the time of the final prosthesis. Most implants (95.5%) revealed marginal bone resorption (<0.5 mm), and just 1 implant (4.5%) showed a change of 2.12 mm from baseline to 36 months (mean 0.07±0.48 mm), while the crestal bone level decreased significantly, from 2.34±0.93 mm at baseline to 1.70±1.10 mm at 36 months. The facial gingival margin and papilla were stable and the esthetic scores indicated high patient and dentist satisfaction. Conclusions Platform-switching bone-level implants placed in maxillary single-tooth gaps resulted in successful osseointegration with minimal marginal bone resorption. The peri-implant soft tissue was also esthetically satisfying and stable. PMID:29093988

  14. The protein level of hypoxia-inducible factor-1alpha is increased in the plateau pika (Ochotona curzoniae) inhabiting high altitudes.

    PubMed

    Li, Hong-Ge; Ren, Yong-Ming; Guo, Song-Chang; Cheng, Long; Wang, De-Peng; Yang, Jie; Chang, Zhi-Jie; Zhao, Xin-Quan

    2009-02-01

    The plateau pika (Ochotona curzoniae) is a high hypoxia-tolerant species living only at 3,000-5,000 m above sea-level on the Qinghai-Tibetan plateau. Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor that regulates a variety of cellular and systemic adaptations to hypoxia. To investigate how the plateau pika adapts to a high-altitude hypoxic environment at the molecular level, we examined the expression pattern of the HIF-1alpha protein in the pika by Western blot and immunohistochemical analysis. We found that HIF-1alpha protein is expressed at a significantly high level in the pika, which is higher in most tissues (particularly in the lung, liver, spleen and kidney) of the plateau pika than that of mice living at sea-level. Importantly, we found that the protein levels of HIF-1alpha in the lung, liver, spleen and kidney of the pika were increased with increased habitat altitudes. We observed that the plateau pika HIF-1alpha localized to the nucleus of cells by an immunostaining analysis, and enhanced HRE-driven gene expression by luciferase reporter assays. Our study suggests that the HIF-1alpha protein levels are related to the adaptation of the plateau pika to the high-altitude hypoxic environment.

  15. High prevalence of elevated blood lead levels in both rural and urban Iowa newborns: Spatial patterns and area-level covariates

    PubMed Central

    Zahrieh, David; Young, Sean G.; Oleson, Jacob; Ryckman, Kelli K.; Wels, Brian; Simmons, Donald L.; Saftlas, Audrey

    2017-01-01

    Lead in maternal blood can cross the placenta and result in elevated blood lead levels in newborns, potentially producing negative effects on neurocognitive function, particularly if combined with childhood lead exposure. Little research exists, however, into the burden of elevated blood lead levels in newborns, or the places and populations in which elevated lead levels are observed in newborns, particularly in rural settings. Using ~2300 dried bloods spots collected within 1–3 days of birth among Iowa newborns, linked with the area of mother’s residence at the time of birth, we examine the spatial patterns of elevated (>5 μg/dL) blood lead levels and the ecological-level predictors of elevated blood lead levels. We find that one in five newborns exceed the 5 μg/dL action level set by the US Centers for Disease Control & Prevention (CDC). Bayesian spatial zero inflated regression indicates that elevated blood lead in newborns is associated with areas of increased pre-1940s housing and childbearing-age women with low educational status in both rural and urban settings. No differences in blood lead levels or the proportion of children exceeding 5 μg/dL are observed between urban and rural maternal residence, though a spatial cluster of elevated blood lead is observed in rural counties. These characteristics can guide the recommendation for testing of infants at well-baby appointments in places where risk factors are present, potentially leading to earlier initiation of case management. The findings also suggest that rural populations are at as great of risk of elevated blood lead levels as are urban populations. Analysis of newborn dried blood spots is an important tool for lead poisoning surveillance in newborns and can direct public health efforts towards specific places and populations where lead testing and case management will have the greatest impact. PMID:28520816

  16. High Resolution Asteroid Profile by Multi Chord Occultation Observations

    NASA Astrophysics Data System (ADS)

    Degenhardt, Scott

    2009-05-01

    For millennia man has observed celestial objects occulting other bodies and distant stars. We have used these celestial synchronicities to measure the properties of objects. On January 1, 1801 Italian astronomer Giusappe Piazzi discovered the first asteroid that would soon be named Ceres. To date 190,000 of these objects have been catalogued, but only a fraction of these have accurate measurements of their true size and shape. The International Occultation Timing Association (IOTA) currently facilitates the prediction and reduction of asteroidal occultations. By measuring the shadow cast on the earth by an asteroid during a stellar occultation one can directly measure the physical size, shape, and position in space of this body to accuracies orders of magnitudes better than the best ground based adaptive optics telescope and can provide verification to 3D inverted reflective lightcurve prediction models. Recent novel methods developed by IOTA involving an individual making multiple observations through unattended remote observing stations have made way for numerous chords of occultation measurement through a single body yielding high resolution profiles of asteroid bodies. Methodology of how observing stations are deployed will be demonstrated, results of some of these observations are presented as comparisons to their inverted lightcurve are shown.

  17. Independent and high-level dual-gene expression in adult stem-progenitor cells from a single lentiviral vector.

    PubMed

    Tian, J; Andreadis, S T

    2009-07-01

    Expression of multiple genes from the same target cell is required in several technological and therapeutic applications such as quantitative measurements of promoter activity or in vivo tracking of stem cells. In spite of such need, reaching independent and high-level dual-gene expression cannot be reliably accomplished by current gene transfer vehicles. To address this issue, we designed a lentiviral vector carrying two transcriptional units separated by polyadenylation, terminator and insulator sequences. With this design, the expression level of both genes was as high as that yielded from lentiviral vectors containing only a single transcriptional unit. Similar results were observed with several promoters and cell types including epidermal keratinocytes, bone marrow mesenchymal stem cells and hair follicle stem cells. Notably, we demonstrated quantitative dynamic monitoring of gene expression in primary cells with no need for selection protocols suggesting that this optimized lentivirus may be useful in high-throughput gene expression profiling studies.

  18. High-level JCPyV viruria after kidney transplantation-Clinical and histopathological findings.

    PubMed

    Helanterä, Ilkka; Hirsch, Hans H; Auvinen, Eeva; Mannonen, Laura; Nummi, Maaret; Wernli, Marion; Ortiz, Fernanda; Räisänen-Sokolowski, Anne; Lempinen, Marko; Lautenschlager, Irmeli

    2016-12-01

    The significance of JC polyomavirus (JCPyV) after kidney transplantation ranges from irrelevant to full-blown nephropathy or PML. To investigate the clinical significance of high-level JCPyV viruria and JCPyV primary infections after kidney transplantation. JCPyV viruria was detected in routine screening by quantitative real-time PCR in 40/238 kidney transplant recipients and was high-level (>10 7 copies/ml) in 17 patients. A protocol biopsy at the time of JCPyV viruria was available from 10 patients. Peak urine viral loads were 1.0×10 7 -2.5×10 9 copies/ml in the 17 high-level viruria patients. 6/15 (40%) patients with high-level JCPyV viruria with pretransplant sera available were JCPyV IgG negative suggesting that JCPyV viruria resulted from the donor graft in most cases. No acute graft dysfunction was associated with JCPyV viruria. No positive SV40 staining was detected in protocol biopsies, and no specific histopathology was associated with high-level viruria; JCPyV nephropathy was not found. No differences were seen in histopathology or graft function at 3 years in patients with high-level viruria compared to non-JCPyV viruric patients transplanted during the same time period, and outcome was similar in patients with presumably primary and reactivated JCPyV. The mean estimated GFR at last follow-up was 44ml/min (range 12-60ml/min). One graft with high-level viruria was lost 9 years posttransplant due to recurrent IgA nephropathy CONCLUSIONS: High-level JCPyV viruria seems to be associated with primary JCPyV infection reflecting the average seroprevalence of 60%, but is not stringently associated with inferior graft function or survival, or histopathological changes. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. High resolution astrophysical observations using speckle imaging

    NASA Astrophysics Data System (ADS)

    Noyes, R. W.; Nisenson, P.; Papaliolios, C.; Stachnik, R. V.

    1986-04-01

    This report describes progress under a contract to develop a complete astronomical speckle image reconstruction facility and to apply that facility to the solution of astronomical problems. During the course of the contract we have developed the procedures, algorithms, theory and hardware required to perform that function and have made and interpreted astronomical observations of substantial significance. A principal result of the program was development of a photon-counting camera of innovative design, the PAPA detector. Development of this device was, in our view, essential to making the speckle process into a useful astronomical tool, since the principal impediment to that circumstance in the past was the necessity for application of photon noise compensation procedures which were difficult if not impossible to calibrate. The photon camera made this procedure unnecessary and permitted precision image recovery. The result of this effort and the associated algorithm development was an active program of astronomical observation which included investigations into young stellar objects, supergiant structure and measurements of the helium abundance of the early universe. We have also continued research on recovery of high angular resolution images of the solar surface working with scientists at the Sacramento Peak Observatory in this area.

  20. Learning high-level features for chord recognition using Autoencoder

    NASA Astrophysics Data System (ADS)

    Phongthongloa, Vilailukkana; Kamonsantiroj, Suwatchai; Pipanmaekaporn, Luepol

    2016-07-01

    Chord transcription is valuable to do by itself. It is known that the manual transcription of chords is very tiresome, time-consuming. It requires, moreover, musical knowledge. Automatic chord recognition has recently attracted a number of researches in the Music Information Retrieval field. It has known that a pitch class profile (PCP) is the commonly signal representation of musical harmonic analysis. However, the PCP may contain additional non-harmonic noise such as harmonic overtones and transient noise. The problem of non-harmonic might be generating the sound energy in term of frequency more than the actual notes of the respective chord. Autoencoder neural network may be trained to learn a mapping from low level feature to one or more higher-level representation. These high-level representations can explain dependencies of the inputs and reduce the effect of non-harmonic noise. Then these improve features are fed into neural network classifier. The proposed high-level musical features show 80.90% of accuracy. The experimental results have shown that the proposed approach can achieve better performance in comparison with other based method.

  1. The ARES High-level Intermediate Representation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Moss, Nicholas David

    The LLVM intermediate representation (IR) lacks semantic constructs for depicting common high-performance operations such as parallel and concurrent execution, communication and synchronization. Currently, representing such semantics in LLVM requires either extending the intermediate form (a signi cant undertaking) or the use of ad hoc indirect means such as encoding them as intrinsics and/or the use of metadata constructs. In this paper we discuss a work in progress to explore the design and implementation of a new compilation stage and associated high-level intermediate form that is placed between the abstract syntax tree and when it is lowered to LLVM's IR. Thismore » highlevel representation is a superset of LLVM IR and supports the direct representation of these common parallel computing constructs along with the infrastructure for supporting analysis and transformation passes on this representation.« less

  2. Deterioration of teeth and alveolar bone loss due to chronic environmental high-level fluoride and low calcium exposure.

    PubMed

    Simon, Maciej J K; Beil, Frank Timo; Riedel, Christoph; Lau, Grace; Tomsia, Antoni; Zimmermann, Elizabeth A; Koehne, Till; Ueblacker, Peter; Rüther, Wolfgang; Pogoda, Pia; Ignatius, Anita; Amling, Michael; Oheim, Ralf

    2016-12-01

    Health risks due to chronic exposure to highly fluoridated groundwater could be underestimated because fluoride might not only influence the teeth in an aesthetic manner but also seems to led to dentoalveolar structure changes. Therefore, we studied the tooth and alveolar bone structures of Dorper sheep chronically exposed to very highly fluoridated and low calcium groundwater in the Kalahari Desert in comparison to controls consuming groundwater with low fluoride and normal calcium levels within the World Health Organization (WHO) recommended range. Two flocks of Dorper ewes in Namibia were studied. Chemical analyses of water, blood and urine were performed. Mineralized tissue investigations included radiography, HR-pQCT analyses, histomorphometry, energy-dispersive X-ray spectroscopy and X-ray diffraction-analyses. Fluoride levels were significantly elevated in water, blood and urine samples in the Kalahari group compared to the low fluoride control samples. In addition to high fluoride, low calcium levels were detected in the Kalahari water. Tooth height and mandibular bone quality were significantly decreased in sheep, exposed to very high levels of fluoride and low levels of calcium in drinking water. Particularly, bone volume and cortical thickness of the mandibular bone were significantly reduced in these sheep. The current study suggests that chronic environmental fluoride exposure with levels above the recommended limits in combination with low calcium uptake can cause significant attrition of teeth and a significant impaired mandibular bone quality. In the presence of high fluoride and low calcium-associated dental changes, deterioration of the mandibular bone and a potential alveolar bone loss needs to be considered regardless whether other signs of systemic skeletal fluorosis are observed or not.

  3. Dysbiosis of Inferior Turbinate Microbiota Is Associated with High Total IgE Levels in Patients with Allergic Rhinitis.

    PubMed

    Hyun, Dong-Wook; Min, Hyun Jin; Kim, Min-Soo; Whon, Tae Woong; Shin, Na-Ri; Kim, Pil Soo; Kim, Hyun Sik; Lee, June Young; Kang, Woorim; Choi, Augustine M K; Yoon, Joo-Heon; Bae, Jin-Woo

    2018-04-01

    Abnormalities in the human microbiota are associated with the etiology of allergic diseases. Although disease site-specific microbiota may be associated with disease pathophysiology, the role of the nasal microbiota is unclear. We sought to characterize the microbiota of the site of allergic rhinitis, the inferior turbinate, in subjects with allergic rhinitis ( n = 20) and healthy controls ( n = 12) and to examine the relationship of mucosal microbiota with disease occurrence, sensitized allergen number, and allergen-specific and total IgE levels. Microbial dysbiosis correlated significantly with total IgE levels representing combined allergic responses but not with disease occurrence, the number of sensitized allergens, or house dust mite allergen-specific IgE levels. Compared to the populations in individuals with low total IgE levels (group IgE low ), low microbial biodiversity with a high relative abundance of Firmicutes phylum ( Staphylococcus aureus ) and a low relative abundance of Actinobacteria phylum ( Propionibacterium acnes ) was observed in individuals with high total serum IgE levels (group IgE high ). Phylogeny-based microbial functional potential predicted by the 16S rRNA gene indicated an increase in signal transduction-related genes and a decrease in energy metabolism-related genes in group IgE high as shown in the microbial features with atopic and/or inflammatory diseases. Thus, dysbiosis of the inferior turbinate mucosa microbiota, particularly an increase in S. aureus and a decrease in P. acnes , is linked to high total IgE levels in allergic rhinitis, suggesting that inferior turbinate microbiota may be affected by accumulated allergic responses against sensitized allergens and that site-specific microbial alterations play a potential role in disease pathophysiology. Copyright © 2018 American Society for Microbiology.

  4. WEAK AND COMPACT RADIO EMISSION IN EARLY HIGH-MASS STAR-FORMING REGIONS. I. VLA OBSERVATIONS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rosero, V.; Hofner, P.; Claussen, M.

    2016-12-01

    We present a high-sensitivity radio continuum survey at 6 and 1.3 cm using the Karl G. Jansky Very Large Array toward a sample of 58 high-mass star-forming regions. Our sample was chosen from dust clumps within infrared dark clouds with and without IR sources (CMC–IRs and CMCs, respectively), and hot molecular cores (HMCs), with no previous, or relatively weak radio continuum detection at the 1 mJy level. Due to the improvement in the continuum sensitivity of the Very Large Array, this survey achieved map rms levels of ∼3–10  μ Jy beam{sup −1} at sub-arcsecond angular resolution. We extracted 70 continuum sourcesmore » associated with 1.2 mm dust clumps. Most sources are weak, compact, and prime candidates for high-mass protostars. Detection rates of radio sources associated with the millimeter dust clumps for CMCs, CMC–IRs, and HMCs are 6%, 53%, and 100%, respectively. This result is consistent with increasing high-mass star formation activity from CMCs to HMCs. The radio sources located within HMCs and CMC–IRs occur close to the dust clump centers, with a median offset from it of 12,000 au and 4000 au, respectively. We calculated 5–25 GHz spectral indices using power-law fits and obtained a median value of 0.5 (i.e., flux increasing with frequency), suggestive of thermal emission from ionized jets. In this paper we describe the sample, observations, and detections. The analysis and discussion will be presented in Paper II.« less

  5. High-level, but not low-level, motion perception is impaired in patients with schizophrenia.

    PubMed

    Kandil, Farid I; Pedersen, Anya; Wehnes, Jana; Ohrmann, Patricia

    2013-01-01

    Smooth pursuit eye movements are compromised in patients with schizophrenia and their first-degree relatives. Although research has demonstrated that the motor components of smooth pursuit eye movements are intact, motion perception has been shown to be impaired. In particular, studies have consistently revealed deficits in performance on tasks specific to the high-order motion area V5 (middle temporal area, MT) in patients with schizophrenia. In contrast, data from low-level motion detectors in the primary visual cortex (V1) have been inconsistent. To differentiate between low-level and high-level visual motion processing, we applied a temporal-order judgment task for motion events and a motion-defined figure-ground segregation task using patients with schizophrenia and healthy controls. Successful judgments in both tasks rely on the same low-level motion detectors in the V1; however, the first task is further processed in the higher-order motion area MT in the magnocellular (dorsal) pathway, whereas the second task requires subsequent computations in the parvocellular (ventral) pathway in visual area V4 and the inferotemporal cortex (IT). These latter structures are supposed to be intact in schizophrenia. Patients with schizophrenia revealed a significantly impaired temporal resolution on the motion-based temporal-order judgment task but only mild impairment in the motion-based segregation task. These results imply that low-level motion detection in V1 is not, or is only slightly, compromised; furthermore, our data restrain the locus of the well-known deficit in motion detection to areas beyond the primary visual cortex.

  6. An integrated framework for high level design of high performance signal processing circuits on FPGAs

    NASA Astrophysics Data System (ADS)

    Benkrid, K.; Belkacemi, S.; Sukhsawas, S.

    2005-06-01

    This paper proposes an integrated framework for the high level design of high performance signal processing algorithms' implementations on FPGAs. The framework emerged from a constant need to rapidly implement increasingly complicated algorithms on FPGAs while maintaining the high performance needed in many real time digital signal processing applications. This is particularly important for application developers who often rely on iterative and interactive development methodologies. The central idea behind the proposed framework is to dynamically integrate high performance structural hardware description languages with higher level hardware languages in other to help satisfy the dual requirement of high level design and high performance implementation. The paper illustrates this by integrating two environments: Celoxica's Handel-C language, and HIDE, a structural hardware environment developed at the Queen's University of Belfast. On the one hand, Handel-C has been proven to be very useful in the rapid design and prototyping of FPGA circuits, especially control intensive ones. On the other hand, HIDE, has been used extensively, and successfully, in the generation of highly optimised parameterisable FPGA cores. In this paper, this is illustrated in the construction of a scalable and fully parameterisable core for image algebra's five core neighbourhood operations, where fully floorplanned efficient FPGA configurations, in the form of EDIF netlists, are generated automatically for instances of the core. In the proposed combined framework, highly optimised data paths are invoked dynamically from within Handel-C, and are synthesized using HIDE. Although the idea might seem simple prima facie, it could have serious implications on the design of future generations of hardware description languages.

  7. High levels of diversity characterize mandrill (Mandrillus sphinx) Mhc-DRB sequences.

    PubMed

    Abbott, Kristin M; Wickings, E Jean; Knapp, Leslie A

    2006-08-01

    The major histocompatibility complex (MHC) is highly polymorphic in most primate species studied thus far. The rhesus macaque (Macaca mulatta) has been studied extensively and the Mhc-DRB region demonstrates variability similar to humans. The extent of MHC diversity is relatively unknown for other Old World monkeys (OWM), especially among genera other than Macaca. A molecular survey of the Mhc-DRB region in mandrills (Mandrillus sphinx) revealed extensive variability, suggesting that other OWMs may also possess high levels of Mhc-DRB polymorphism. In the present study, 33 Mhc-DRB loci were identified from only 13 animals. Eleven were wild-born and presumed to be unrelated and two were captive-born twins. Two to seven different sequences were identified for each individual, suggesting that some mandrills may have as many as four Mhc-DRB loci on a single haplotype. From these sequences, representatives of at least six Mhc-DRB loci or lineages were identified. As observed in other primates, some new lineages may have arisen through the process of gene conversion. These findings indicate that mandrills have Mhc-DRB diversity not unlike rhesus macaques and humans.

  8. Observation of polariton resonances with five-level M-type atoms in an optical cavity

    NASA Astrophysics Data System (ADS)

    Liu, Yutong; Lin, Gongwei; Ying, Kang; Liang, Lin; Niu, Yueping; Gong, Shangqing

    2017-11-01

    We study the polariton resonances with the five-level M-type atoms inside an optical cavity through the observation of the cavity transmission spectrum. The ultranarrow peaks associated with the dark-state polaritons in the system can be achieved by adjusting three coupling fields. Simple theory analysis and numerical simulations are also presented.

  9. High breast milk IL-1β level is associated with reduced risk of childhood eczema.

    PubMed

    Jepsen, A A; Chawes, B L; Carson, C G; Schoos, A-M M; Thysen, A H; Waage, J; Brix, S; Bisgaard, H

    2016-10-01

    We recently demonstrated a dual effect of breastfeeding with increased risk of eczema and decreased risk of wheezing in early childhood by increasing breastfeeding length. We hypothesize that immune mediators in breast milk could explain such association either through a direct effect or as a surrogate marker of maternal immune constitution. To investigate the possible association between cytokine and chemokine levels in breast milk and development of eczema and recurrent wheeze during early childhood. Levels of 19 pro-inflammatory and immunoregulatory cytokines and chemokines were measured in 223 breast milk samples from mothers in the Copenhagen Prospective Study on Asthma in Childhood2000 (COPSAC) high-risk birth cohort. Eczema and recurrent wheeze at the age of 0-3 years were prospectively diagnosed by COPSAC physicians adherent to predefined validated algorithms. Association analyses were performed by Cox regression adjusting for potential confounding factors and by multivariable principal component analysis. Increased IL-1β in breast milk (≥ 0.7 pg/mL) was associated with more than a halved risk of eczema before age three (aHR = 0.41; 95% CI = 0.24-0.68; P < 0.001), which remained significant after false discovery rate adjustment (P = 0.008). The principal component analysis confirmed that a mediator pattern dominated by high levels of IL-1β, IL-17A, and CCL17 and low levels of CXCL1 and TSLP in breast milk protected against eczema (aHR = 0.82; 95% CI = 0.68-0.98; P = 0.03). No associations were observed for recurrent wheeze. Elevated breast milk IL-1β level was associated with decreased risk of early childhood eczema suggesting either a direct protective effect of IL-1β or IL-1b acting as a proxy for a healthy maternal immune system protecting high-risk offspring from eczema. © 2016 John Wiley & Sons Ltd.

  10. NICER observations of highly magnetized neutron stars: Initial results

    NASA Astrophysics Data System (ADS)

    Enoto, Teruaki; Arzoumanian, Zaven; Gendreau, Keith C.; Nynka, Melania; Kaspi, Victoria; Harding, Alice; Guver, Tolga; Lewandowska, Natalia; Majid, Walid; Ho, Wynn C. G.; NICER Team

    2018-01-01

    The Neutron star Interior Composition Explorer (NICER) was launched on June 3, 2017, and attached to the International Space Station. The large effective area of NICER in soft X-rays makes it a powerful tool not only for its primary science objective (diagnostics of the nuclear equation state) but also for studying neutron stars of various classes. As one of the NICER science working groups, the Magnetars and Magnetospheres (M&M) team coordinates monitoring and target of opportunity (ToO) observations of magnetized neutron stars, including magnetars, high-B pulsars, X-ray dim isolated neutron stars, and young rotation-powered pulsars. The M&M working group has performed simultaneous X-ray and radio observations of the Crab and Vela pulsars, ToO observations of the active anomalous X-ray pulsar 4U 0142+61, and a monitoring campaign for the transient magnetar SGR 0501+4516. Here we summarize the current status and initial results of the M&M group.

  11. A map of human microRNA variation uncovers unexpectedly high levels of variability

    PubMed Central

    2012-01-01

    Background MicroRNAs (miRNAs) are key components of the gene regulatory network in many species. During the past few years, these regulatory elements have been shown to be involved in an increasing number and range of diseases. Consequently, the compilation of a comprehensive map of natural variability in a healthy population seems an obvious requirement for future research on miRNA-related pathologies. Methods Data on 14 populations from the 1000 Genomes Project were analyzed, along with new data extracted from 60 exomes of healthy individuals from a population from southern Spain, sequenced in the context of the Medical Genome Project, to derive an accurate map of miRNA variability. Results Despite the common belief that miRNAs are highly conserved elements, analysis of the sequences of the 1,152 individuals indicated that the observed level of variability is double what was expected. A total of 527 variants were found. Among these, 45 variants affected the recognition region of the corresponding miRNA and were found in 43 different miRNAs, 26 of which are known to be involved in 57 diseases. Different parts of the mature structure of the miRNA were affected to different degrees by variants, which suggests the existence of a selective pressure related to the relative functional impact of the change. Moreover, 41 variants showed a significant deviation from the Hardy-Weinberg equilibrium, which supports the existence of a selective process against some alleles. The average number of variants per individual in miRNAs was 28. Conclusions Despite an expectation that miRNAs would be highly conserved genomic elements, our study reports a level of variability comparable to that observed for coding genes. PMID:22906193

  12. Snack intake is reduced using an implicit, high-level construal cue.

    PubMed

    Price, Menna; Higgs, Suzanne; Lee, Michelle

    2016-08-01

    Priming a high level construal has been shown to enhance self-control and reduce preference for indulgent food. Subtle visual cues have been shown to enhance the effects of a priming procedure. The current study therefore examined the combined impact of construal level and a visual cue reminder on the consumption of energy-dense snacks. A student and community-based adult sample with a wide age and body mass index (BMI) range (N = 176) were randomly assigned to a high or low construal condition in which a novel symbol was embedded. Afterward participants completed a taste test of ad libitum snack foods in the presence or absence of the symbol. The high (vs. the low) construal level prime successfully generated more abstract responses (p < .0001) and reduced intake when the cue-reminder was present (p = .02) but not when it was absent (p = .40). Priming high construal level thinking reduces consumption of high energy dense snacks in the presence of a visual cue-reminder. This may be a practical technique for reducing overeating and has the potential to be extended to other unhealthy behaviors. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  13. Variations of the TeV energy spectrum at different flux levels of Mkn 421 observed with the HEGRA system of Cherenkov telescopes

    NASA Astrophysics Data System (ADS)

    Aharonian, F.; Akhperjanian, A.; Beilicke, M.; Bernlöhr, K.; Börst, H.; Bojahr, H.; Bolz, O.; Coarasa, T.; Contreras, J.; Cortina, J.; Costamante, L.; Denninghoff, S.; Fonseca, V.; Girma, M.; Götting, N.; Heinzelmann, G.; Hermann, G.; Heusler, A.; Hofmann, W.; Horns, D.; Jung, I.; Kankanyan, R.; Kestel, M.; Kettler, J.; Kohnle, A.; Konopelko, A.; Kornmeyer, H.; Kranich, D.; Krawczynski, H.; Lampeitl, H.; Lopez, M.; Lorenz, E.; Lucarelli, F.; Mang, O.; Meyer, H.; Mirzoyan, R.; Milite, M.; Moralejo, A.; Ona, E.; Panter, M.; Plyasheshnikov, A.; Pühlhofer, G.; Rauterberg, G.; Reyes, R.; Rhode, W.; Ripken, J.; Rowell, G.; Sahakian, V.; Samorski, M.; Schilling, M.; Siems, M.; Sobzynska, D.; Stamm, W.; Tluczykont, M.; Völk, H. J.; Wiedner, C. A.; Wittek, W.; Remillard, R. A.

    2002-10-01

    The nearby BL Lacertae (BL Lac) object Markarian 421 (Mkn 421) at a red shift z=0.031 was observed to undergo strong TeV gamma -ray outbursts in the observational periods from December 1999 until May 2001. The time averaged flux level F(E>1 TeV) in the 1999/2000 season was (1.43+/-0.04) x 10-11 ph cm-2 s-1, whereas in the 2000/2001 season the average integral flux increased to (4.19+/-0.04) x 10-11 ph cm-2 s-1. Both energy spectra are curved and well fit by a power law with an exponential cut-off energy at 3.6(+0.4-0.3)_stat(+0.9-0.8)_sys TeV. The respective energy spectra averaged over each of the two time periods indicate a spectral hardening for the 2000/2001 spectrum. The photon index changes from 2.39+/-0.09_stat for 1999/2000 to 2.19+/-0.02_stat in 2000/2001. The energy spectra derived for different average flux levels ranging from 0.5 to 10 x 10-11 ph cm-2 s-1 follow a clear correlation of photon index and flux level. Generally, the energy spectra are harder for high flux levels. From January to April 2001 Mkn 421 showed rapid variability (doubling time as short as 20 min), accompanied with a spectral hardening with increasing flux level within individual nights. For two successive nights (MJD 51989-51991, March 21-23, 2001), this correlation of spectral hardness and change in flux has been observed within a few hours. The cut-off energy for the Mkn 421 TeV spectrum remains within the errors constant for the different flux levels and differs by Delta E=2.6+/-0.6_stat+/-0.6_sys TeV from the value determined for Mkn 501. This indicates that the observed exponential cut-off in the energy spectrum of Mkn 421 is not solely caused by absorption of multi-TeV photons by pair-production processes with photons of the extragalactic near/mid infrared background radiation.

  14. Randomized Comparison of 3 High-Level Disinfection and Sterilization Procedures for Duodenoscopes.

    PubMed

    Snyder, Graham M; Wright, Sharon B; Smithey, Anne; Mizrahi, Meir; Sheppard, Michelle; Hirsch, Elizabeth B; Chuttani, Ram; Heroux, Riley; Yassa, David S; Olafsdottir, Lovisa B; Davis, Roger B; Anastasiou, Jiannis; Bapat, Vijay; Bidari, Kiran; Pleskow, Douglas K; Leffler, Daniel; Lane, Benjamin; Chen, Alice; Gold, Howard S; Bartley, Anthony; King, Aleah D; Sawhney, Mandeep S

    2017-10-01

    Duodenoscopes have been implicated in the transmission of multidrug-resistant organisms (MDRO). We compared the frequency of duodenoscope contamination with MDRO or any other bacteria after disinfection or sterilization by 3 different methods. We performed a single-center prospective randomized study in which duodenoscopes were randomly reprocessed by standard high-level disinfection (sHLD), double high-level disinfection (dHLD), or standard high-level disinfection followed by ethylene oxide gas sterilization (HLD/ETO). Samples were collected from the elevator mechanism and working channel of each duodenoscope and cultured before use. The primary outcome was the proportion of duodenoscopes with an elevator mechanism or working channel culture showing 1 or more MDRO; secondary outcomes included the frequency of duodenoscope contamination with more than 0 and 10 or more colony-forming units (CFU) of aerobic bacterial growth on either sampling location. After 3 months of enrollment, the study was closed because of the futility; we did not observe sufficient events to evaluate the primary outcome. Among 541 duodenoscope culture events, 516 were included in the final analysis. No duodenoscope culture in any group was positive for MDRO. Bacterial growth of more than 0 CFU was noted in 16.1% duodenoscopes in the sHLD group, 16.0% in the dHLD group, and 22.5% in the HLD/ETO group (P = .21). Bacterial growth or 10 or more CFU was noted in 2.3% of duodenoscopes in the sHLD group, 4.1% in the dHLD group, and 4.2% in the HLD/ETO group (P = .36). MRDOs were cultured from 3.2% of pre-procedure rectal swabs and 2.5% of duodenal aspirates. In a comparison of duodenoscopes reprocessed by sHLD, dHLD, or HLD/ETO, we found no significant differences between groups for MDRO or bacteria contamination. Enhanced disinfection methods (dHLD or HLD/ETO) did not provide additional protection against contamination. However, insufficient events occurred to assess our primary study end

  15. Direct observation of closed magnetic flux trapped in the high-latitude magnetosphere.

    PubMed

    Fear, R C; Milan, S E; Maggiolo, R; Fazakerley, A N; Dandouras, I; Mende, S B

    2014-12-19

    The structure of Earth's magnetosphere is poorly understood when the interplanetary magnetic field is northward. Under this condition, uncharacteristically energetic plasma is observed in the magnetotail lobes, which is not expected in the textbook model of the magnetosphere. Using satellite observations, we show that these lobe plasma signatures occur on high-latitude magnetic field lines that have been closed by the fundamental plasma process of magnetic reconnection. Previously, it has been suggested that closed flux can become trapped in the lobe and that this plasma-trapping process could explain another poorly understood phenomenon: the presence of auroras at extremely high latitudes, called transpolar arcs. Observations of the aurora at the same time as the lobe plasma signatures reveal the presence of a transpolar arc. The excellent correspondence between the transpolar arc and the trapped closed flux at high altitudes provides very strong evidence of the trapping mechanism as the cause of transpolar arcs. Copyright © 2014, American Association for the Advancement of Science.

  16. Creep Strain and Strain Rate Response of 2219 Al Alloy at High Stress Levels

    NASA Technical Reports Server (NTRS)

    Taminger, Karen M. B.; Wagner, John A.; Lisagor, W. Barry

    1998-01-01

    As a result of high localized plastic deformation experienced during proof testing in an International Space Station connecting module, a study was undertaken to determine the deformation response of a 2219-T851 roll forging. After prestraining 2219-T851 Al specimens to simulate strains observed during the proof testing, creep tests were conducted in the temperature range from ambient temperature to 107 C (225 F) at stress levels approaching the ultimate tensile strength of 2219-T851 Al. Strain-time histories and strain rate responses were examined. The strain rate response was extremely high initially, but decayed rapidly, spanning as much as five orders of magnitude during primary creep. Select specimens were subjected to incremental step loading and exhibited initial creep rates of similar magnitude for each load step. Although the creep rates decreased quickly at all loads, the creep rates dropped faster and reached lower strain rate levels for lower applied loads. The initial creep rate and creep rate decay associated with primary creep were similar for specimens with and without prestrain; however, prestraining (strain hardening) the specimens, as in the aforementioned proof test, resulted in significantly longer creep life.

  17. Teaching a High-Level Contextualized Mathematics Curriculum to Adult Basic Learners

    ERIC Educational Resources Information Center

    Showalter, Daniel A.; Wollett, Chelsie; Reynolds, Sharon

    2014-01-01

    This paper reports on the implementation of a high level contextualized mathematics curriculum by 12 adult basic instructors in a midwestern state. The 10-week pilot curriculum embedded high level mathematics in contexts that were familiar to adult learners. Instructors' weekly online posts were coded, and the following themes emerged: (a)…

  18. High-resolution continuum observations of the Sun

    NASA Technical Reports Server (NTRS)

    Zirin, Harold

    1987-01-01

    The aim of the PFI or photometric filtergraph instrument is to observe the Sun in the continuum with as high resolution as possible and utilizing the widest range of wavelengths. Because of financial and political problems the CCD was eliminated so that the highest photometric accuracy is only obtainable by comparison with the CFS images. Presently there is a limitation to wavelengths above 2200 A due to the lack of sensitivity of untreated film below 2200 A. Therefore the experiment at present consists of a film camera with 1000 feet of film and 12 filters. The PFI experiments are outlined using only two cameras. Some further problems of the experiment are addressed.

  19. LTE modeling of inhomogeneous chromospheric structure using high-resolution limb observations

    NASA Technical Reports Server (NTRS)

    Lindsey, C.

    1987-01-01

    The paper discusses considerations relevant to LTE modeling of rough atmospheres. Particular attention is given to the application of recent high-resolution observations of the solar limb in the far-infrared and radio continuum to the modeling of chromospheric spicules. It is explained how the continuum limb observations can be combined with morphological knowledge of spicule structure to model the physical conditions in chromospheric spicules. This discussion forms the basis for a chromospheric model presented in a parallel publication based on observations ranging from 100 microns to 2.6 mm.

  20. Discourse analysis of an 'observation levels' nursing policy.

    PubMed

    Horsfall, J; Cleary, M

    2000-11-01

    The practice of special observation (or constant observation) is widely used in inpatient psychiatric facilities for the care of people who are suicidal. In this study, the policy of special observation was examined using a discourse analysis method to discern prevailing ideas and practices highlighted within the policy. After reading, studying and analysing the special observation nursing policy, the authors briefly describe the document and outline the terms and phrases prevalent within the document. These recurrent ideas are then organized into five categories: professional responsibilities, suicidality, the patient's immediate context, the patient's observable behaviour and the nursing checklist. In discussion of the policy document, the invisibility of the authors, target audience and patients is noted. The authors attempt to elicit evidence for the therapeutic nurse-patient relationship in the document. In the analysis of patient, nurse and doctor roles and responsibilities, it is evident that the policy document reinforces the traditional medical hierarchy of power relations. Some assumptions that underpin the document are postulated. Questions regarding the nature of risk assessment and the evidence base for the medical prescription of special observation are raised. As well as ideas and themes evident in the document, the absence of some relevant issues is explored. While the need for succinctness and clarity in policy documents is acknowledged, the fact that patient rights, therapeutic processes and ethical dilemmas are absent is deemed significant.

  1. Automatic rule generation for high-level vision

    NASA Technical Reports Server (NTRS)

    Rhee, Frank Chung-Hoon; Krishnapuram, Raghu

    1992-01-01

    Many high-level vision systems use rule-based approaches to solving problems such as autonomous navigation and image understanding. The rules are usually elaborated by experts. However, this procedure may be rather tedious. In this paper, we propose a method to generate such rules automatically from training data. The proposed method is also capable of filtering out irrelevant features and criteria from the rules.

  2. Adapting high-level language programs for parallel processing using data flow

    NASA Technical Reports Server (NTRS)

    Standley, Hilda M.

    1988-01-01

    EASY-FLOW, a very high-level data flow language, is introduced for the purpose of adapting programs written in a conventional high-level language to a parallel environment. The level of parallelism provided is of the large-grained variety in which parallel activities take place between subprograms or processes. A program written in EASY-FLOW is a set of subprogram calls as units, structured by iteration, branching, and distribution constructs. A data flow graph may be deduced from an EASY-FLOW program.

  3. Role of light satellites in the high-resolution Earth observation domain

    NASA Astrophysics Data System (ADS)

    Fishman, Moshe

    1999-12-01

    Current 'classic' applications using and exploring space based earth imagery are exclusive, narrow niche tailored, expensive and hardly accessible. On the other side new, inexpensive and widely used 'consumable' applications will be only developed concurrently to the availability of appropriate imagery allowing that process. A part of these applications can be imagined today, like WWW based 'virtual tourism' or news media, but the history of technological, cultural and entertainment evolution teaches us that most of future applications are unpredictable -- they emerge together with the platforms enabling their appearance. The only thing, which can be ultimately stated, is that the definitive condition for such applications is the availability of the proper imagery platform providing low cost, high resolution, large area, quick response, simple accessibility and quick dissemination of the raw picture. This platform is a constellation of Earth Observation satellites. Up to 1995 the Space Based High Resolution Earth Observation Domain was dominated by heavy, super-expensive and very inflexible birds. The launch of Israeli OFEQ-3 Satellite by MBT Division of Israel Aircraft Industries (IAI) marked the entrance to new era of light, smart and cheap Low Earth Orbited Imaging satellites. The Earth Resource Observation System (EROS) initiated by West Indian Space, is based on OFEQ class Satellites design and it is capable to gather visual data of Earth Surface both at high resolution and large image capacity. The main attributes, derived from its compact design, low weight and sophisticated logic and which convert the EROS Satellite to valuable and productive system, are discussed. The major advantages of Light Satellites in High Resolution Earth Observation Domain are presented and WIS guidelines featuring the next generation of LEO Imaging Systems are included.

  4. Variational study on the vibrational level structure and vibrational level mixing of highly vibrationally excited S₀ D₂CO.

    PubMed

    Rashev, Svetoslav; Moule, David C; Rashev, Vladimir

    2012-11-01

    We perform converged high precision variational calculations to determine the frequencies of a large number of vibrational levels in S(0) D(2)CO, extending from low to very high excess vibrational energies. For the calculations we use our specific vibrational method (recently employed for studies on H(2)CO), consisting of a combination of a search/selection algorithm and a Lanczos iteration procedure. Using the same method we perform large scale converged calculations on the vibrational level spectral structure and fragmentation at selected highly excited overtone states, up to excess vibrational energies of ∼17,000 cm(-1), in order to study the characteristics of intramolecular vibrational redistribution (IVR), vibrational level density and mode selectivity. Copyright © 2012 Elsevier B.V. All rights reserved.

  5. POST-OUTBURST RADIO OBSERVATIONS OF THE HIGH MAGNETIC FIELD PULSAR PSR J1119-6127

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Majid, Walid A.; Pearlman, Aaron B.; Dobreva, Tatyana

    We have carried out high-frequency radio observations of the high magnetic field pulsar PSR J1119-6127 following its recent X-ray outburst. While initial observations showed no evidence of significant radio emission, subsequent observations detected pulsed emission across a large frequency band. In this Letter, we report on the initial disappearance of the pulsed emission and its prompt reactivation and dramatic evolution over several months of observation. The periodic pulse profile at S -band (2.3 GHz) after reactivation exhibits a multi-component emission structure, while the simultaneous X -band (8.4 GHz) profile shows a single emission peak. Single pulses were also detected atmore » S -band near the main emission peaks. We present measurements of the spectral index across a wide frequency bandwidth, which captures the underlying changes in the radio emission profile of the neutron star. The high-frequency radio detection, unusual emission profile, and observed variability suggest similarities with magnetars, which may independently link the high-energy outbursts to magnetar-like behavior.« less

  6. Low-mode internal tides and balanced dynamics disentanglement in altimetric observations: Synergy with surface density observations

    NASA Astrophysics Data System (ADS)

    Ponte, Aurélien L.; Klein, Patrice; Dunphy, Michael; Le Gentil, Sylvie

    2017-03-01

    The performance of a tentative method that disentangles the contributions of a low-mode internal tide on sea level from that of the balanced mesoscale eddies is examined using an idealized high resolution numerical simulation. This disentanglement is essential for proper estimation from sea level of the ocean circulation related to balanced motions. The method relies on an independent observation of the sea surface water density whose variations are 1/dominated by the balanced dynamics and 2/correlate with variations of potential vorticity at depth for the chosen regime of surface-intensified turbulence. The surface density therefore leads via potential vorticity inversion to an estimate of the balanced contribution to sea level fluctuations. The difference between instantaneous sea level (presumably observed with altimetry) and the balanced estimate compares moderately well with the contribution from the low-mode tide. Application to realistic configurations remains to be tested. These results aim at motivating further developments of reconstruction methods of the ocean dynamics based on potential vorticity dynamics arguments. In that context, they are particularly relevant for the upcoming wide-swath high resolution altimetric missions (SWOT).

  7. A telescopic cinema sound camera for observing high altitude aerospace vehicles

    NASA Astrophysics Data System (ADS)

    Slater, Dan

    2014-09-01

    Rockets and other high altitude aerospace vehicles produce interesting visual and aural phenomena that can be remotely observed from long distances. This paper describes a compact, passive and covert remote sensing system that can produce high resolution sound movies at >100 km viewing distances. The telescopic high resolution camera is capable of resolving and quantifying space launch vehicle dynamics including plume formation, staging events and payload fairing jettison. Flight vehicles produce sounds and vibrations that modulate the local electromagnetic environment. These audio frequency modulations can be remotely sensed by passive optical and radio wave detectors. Acousto-optic sensing methods were primarily used but an experimental radioacoustic sensor using passive micro-Doppler radar techniques was also tested. The synchronized combination of high resolution flight vehicle imagery with the associated vehicle sounds produces a cinema like experience that that is useful in both an aerospace engineering and a Hollywood film production context. Examples of visual, aural and radar observations of the first SpaceX Falcon 9 v1.1 rocket launch are shown and discussed.

  8. Constraining the low-cloud optical depth feedback at middle and high latitudes using satellite observations

    DOE PAGES

    Terai, C. R.; Klein, S. A.; Zelinka, M. D.

    2016-08-26

    The increase in cloud optical depth with warming at middle and high latitudes is a robust cloud feedback response found across all climate models. This study builds on results that suggest the optical depth response to temperature is timescale invariant for low-level clouds. The timescale invariance allows one to use satellite observations to constrain the models' optical depth feedbacks. Three passive-sensor satellite retrievals are compared against simulations from eight models from the Atmosphere Model Intercomparison Project (AMIP) of the 5th Coupled Model Intercomparison Project (CMIP5). This study confirms that the low-cloud optical depth response is timescale invariant in the AMIPmore » simulations, generally at latitudes higher than 40°. Compared to satellite estimates, most models overestimate the increase in optical depth with warming at the monthly and interannual timescales. Many models also do not capture the increase in optical depth with estimated inversion strength that is found in all three satellite observations and in previous studies. The discrepancy between models and satellites exists in both hemispheres and in most months of the year. A simple replacement of the models' optical depth sensitivities with the satellites' sensitivities reduces the negative shortwave cloud feedback by at least 50% in the 40°–70°S latitude band and by at least 65% in the 40°–70°N latitude band. Furthermore, based on this analysis of satellite observations, we conclude that the low-cloud optical depth feedback at middle and high latitudes is likely too negative in climate models.« less

  9. Constraining the low-cloud optical depth feedback at middle and high latitudes using satellite observations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Terai, C. R.; Klein, S. A.; Zelinka, M. D.

    The increase in cloud optical depth with warming at middle and high latitudes is a robust cloud feedback response found across all climate models. This study builds on results that suggest the optical depth response to temperature is timescale invariant for low-level clouds. The timescale invariance allows one to use satellite observations to constrain the models' optical depth feedbacks. Three passive-sensor satellite retrievals are compared against simulations from eight models from the Atmosphere Model Intercomparison Project (AMIP) of the 5th Coupled Model Intercomparison Project (CMIP5). This study confirms that the low-cloud optical depth response is timescale invariant in the AMIPmore » simulations, generally at latitudes higher than 40°. Compared to satellite estimates, most models overestimate the increase in optical depth with warming at the monthly and interannual timescales. Many models also do not capture the increase in optical depth with estimated inversion strength that is found in all three satellite observations and in previous studies. The discrepancy between models and satellites exists in both hemispheres and in most months of the year. A simple replacement of the models' optical depth sensitivities with the satellites' sensitivities reduces the negative shortwave cloud feedback by at least 50% in the 40°–70°S latitude band and by at least 65% in the 40°–70°N latitude band. Furthermore, based on this analysis of satellite observations, we conclude that the low-cloud optical depth feedback at middle and high latitudes is likely too negative in climate models.« less

  10. Tracking forest canopy dynamics from an automated proximal hyperspectral monitoring system: linking remote sensing observations to leaf level photosynthetic processes

    NASA Astrophysics Data System (ADS)

    Woodgate, W.; van Gorsel, E.; Hughes, D.; Suarez, L.; Cabello-Leblic, A.; Held, A. A.; Norton, A.; Dempsey, R.

    2017-12-01

    To better understand the vegetation response to climate extremes we have developed a fully automated hyperspectral and thermal monitoring system installed on a flux tower at a mature Eucalypt forest site - Tumbarumba, Australia. The automated system bridges spatial, spectral and temporal scales between satellite and in situ observations. Here, we have been acquiring high resolution panoramic hyperspectral and thermal images of the forest canopy three times per day since mid-2014.A specific focus of the work to date has been linking light use efficiency (LUE) as measured by the flux tower to remote sensing observations from the leaf, to crown, to canopy scale. Specifically, targeted field campaigns were conducted in 2016 to establish the interrelationship between structure, function, and spectra. At the leaf level destructive sampling to quantify photosynthetic pigments was conducted to pick apart the mechanisms contributing to photosynthetic processes of non-photochemical quenching and the resultant changes in observed leaf spectra. At the crown level, Terrestrial Laser Scanning data was used to derive canopy structural information, enabling distance to crown and crown foliage density to be calculated to a fine degree of detail. This information is critical for correcting attenuation of the thermal signal from atmospheric transmission, and to distinguish the relative foliage-to-soil contribution to the thermal and hyperspectral imagery. Ancillary data streams from sap flow and dendrometer devices serve to link leaf, crown and canopy observations.Preliminary results of the leaf and crown level relationships between function and spectra will be discussed. We will demonstrate that operating in a tall canopy (40m) forest can lead to additional complexities. We have found the relationship strength between traditional remote sensing LUE proxies and photosynthetic proxies derived from pigments varies strongly with canopy height and pigment pool size. Additionally, the

  11. Biochemical, hydrological and mechanical behaviors of high food waste content MSW landfill: Liquid-gas interactions observed from a large-scale experiment.

    PubMed

    Zhan, Liang-Tong; Xu, Hui; Chen, Yun-Min; Lan, Ji-Wu; Lin, Wei-An; Xu, Xiao-Bing; He, Pin-Jing

    2017-10-01

    The high food waste content (HFWC) MSW at a landfill has the characteristics of rapid hydrolysis process, large leachate production rate and fast gas generation. The liquid-gas interactions at HFWC-MSW landfills are prominent and complex, and still remain significant challenges. This paper focuses on the liquid-gas interactions of HFWC-MSW observed from a large-scale bioreactor landfill experiment (5m×5m×7.5m). Based on the connected and quantitative analyses on the experimental observations, the following findings were obtained: (1) The high leachate level observed at Chinese landfills was attributed to the combined contribution from the great quantity of self-released leachate, waste compression and gas entrapped underwater. The contribution from gas entrapped underwater was estimated to be 21-28% of the total leachate level. (2) The gas entrapped underwater resulted in a reduction of hydraulic conductivity, decreasing by one order with an increase in gas content from 13% to 21%. (3) The "breakthrough value" in the gas accumulation zone was up to 11kPa greater than the pore liquid pressure. The increase of the breakthrough value was associated with the decrease of void porosity induced by surcharge loading. (4) The self-released leachate from HFWC-MSW was estimated to contribute to over 30% of the leachate production at landfills in Southern China. The drainage of leachate with a high organic loading in the rapid hydrolysis stage would lead to a loss of landfill gas (LFG) potential of 13%. Based on the above findings, an improved method considering the quantity of self-released leachate was proposed for the prediction of leachate production at HFWC-MSW landfills. In addition, a three-dimensional drainage system was proposed to drawdown the high leachate level and hence to improve the slope stability of a landfill, reduce the hydraulic head on a bottom liner and increase the collection efficiency for LFG. Copyright © 2017. Published by Elsevier Ltd.

  12. High-Level Heteroatom Doped Two-Dimensional Carbon Architectures for Highly Efficient Lithium-Ion Storage.

    PubMed

    Wang, Zhijie; Wang, Yanyan; Wang, Wenhui; Yu, Xiaoliang; Lv, Wei; Xiang, Bin; He, Yan-Bing

    2018-01-01

    In this work, high-level heteroatom doped two-dimensional hierarchical carbon architectures (H-2D-HCA) are developed for highly efficient Li-ion storage applications. The achieved H-2D-HCA possesses a hierarchical 2D morphology consisting of tiny carbon nanosheets vertically grown on carbon nanoplates and containing a hierarchical porosity with multiscale pore size. More importantly, the H-2D-HCA shows abundant heteroatom functionality, with sulfur (S) doping of 0.9% and nitrogen (N) doping of as high as 15.5%, in which the electrochemically active N accounts for 84% of total N heteroatoms. In addition, the H-2D-HCA also has an expanded interlayer distance of 0.368 nm. When used as lithium-ion battery anodes, it shows excellent Li-ion storage performance. Even at a high current density of 5 A g -1 , it still delivers a high discharge capacity of 329 mA h g -1 after 1,000 cycles. First principle calculations verifies that such unique microstructure characteristics and high-level heteroatom doping nature can enhance Li adsorption stability, electronic conductivity and Li diffusion mobility of carbon nanomaterials. Therefore, the H-2D-HCA could be promising candidates for next-generation LIB anodes.

  13. High-Level Heteroatom Doped Two-Dimensional Carbon Architectures for Highly Efficient Lithium-Ion Storage

    PubMed Central

    Wang, Zhijie; Wang, Yanyan; Wang, Wenhui; Yu, Xiaoliang; Lv, Wei; Xiang, Bin; He, Yan-Bing

    2018-01-01

    In this work, high-level heteroatom doped two-dimensional hierarchical carbon architectures (H-2D-HCA) are developed for highly efficient Li-ion storage applications. The achieved H-2D-HCA possesses a hierarchical 2D morphology consisting of tiny carbon nanosheets vertically grown on carbon nanoplates and containing a hierarchical porosity with multiscale pore size. More importantly, the H-2D-HCA shows abundant heteroatom functionality, with sulfur (S) doping of 0.9% and nitrogen (N) doping of as high as 15.5%, in which the electrochemically active N accounts for 84% of total N heteroatoms. In addition, the H-2D-HCA also has an expanded interlayer distance of 0.368 nm. When used as lithium-ion battery anodes, it shows excellent Li-ion storage performance. Even at a high current density of 5 A g−1, it still delivers a high discharge capacity of 329 mA h g−1 after 1,000 cycles. First principle calculations verifies that such unique microstructure characteristics and high-level heteroatom doping nature can enhance Li adsorption stability, electronic conductivity and Li diffusion mobility of carbon nanomaterials. Therefore, the H-2D-HCA could be promising candidates for next-generation LIB anodes. PMID:29686985

  14. High-Level Heteroatom Doped Two-Dimensional Carbon Architectures for Highly Efficient Lithium-Ion Storage

    NASA Astrophysics Data System (ADS)

    Wang, Zhijie; Wang, Yanyan; Wang, Wenhui; Yu, Xiaoliang; Lv, Wei; Xiang, Bin; He, Yan-Bing

    2018-04-01

    In this work, high-level heteroatom doped two-dimensional hierarchical carbon architectures (H-2D-HCA) are developed for highly efficient Li-ion storage applications. The achieved H-2D-HCA possesses a hierarchical 2D morphology consisting of tiny carbon nanosheets vertically grown on carbon nanoplates and containing a hierarchical porosity with multiscale pore size. More importantly, the H-2D-HCA shows abundant heteroatom functionality, with sulfur (S) doping of 0.9 % and nitrogen (N) doping of as high as 15.5 %, in which the electrochemically active N accounts for 84 % of total N heteroatoms. In addition, the H-2D-HCA also has an expanded interlayer distance of 0.368 nm. When used as lithium-ion battery anodes, it shows excellent Li-ion storage performance. Even at a high current density of 5 A g-1, it still delivered a high discharge capacity of 329 mA h g-1 after 1000 cycles. First principle calculations verified that such unique microstructure characteristics and high-level heteroatom doping nature can enhance Li adsorption stability, electronic conductivity and Li diffusion mobility of carbon nanomaterials. Therefore, the H-2D-HCA could be promising candidates for next-generation LIB anodes.

  15. Observation of ultrahigh-energy electrons by resonance absorption of high-power microwaves in a pulsed plasma.

    PubMed

    Rajyaguru, C; Fuji, T; Ito, H; Yugami, N; Nishida, Y

    2001-07-01

    The interaction of high power microwave with collisionless unmagnetized plasma is studied. Investigation on the generation of superthermal electrons near the critical layer, by the resonance absorption phenomenon, is extended to very high microwave power levels (eta=E(2)(0)/4 pi n(e)kT(e) approximately 0.3). Here E0, n(e), and T(e) are the vacuum electric field, electron density, and electron temperature, respectively. Successive generation of electron bunches having maximum energy of about 2 keV, due to nonlinear wave breaking, is observed. The electron energy epsilon scales as a function of the incident microwave power P, according to epsilon proportional to P0.5 up to 250 kW. The two-dimensional spatial distribution of high energy electrons reveals that they are generated near the critical layer. However, the lower energy component is again produced in the subcritical density region indicating the possibility of other electron heating mechanisms.

  16. The impact of Doppler lidar wind observations on a single-level meteorological analysis

    NASA Technical Reports Server (NTRS)

    Riishojgaard, L. P.; Atlas, R.; Emmitt, G. D.

    2001-01-01

    Through the use of observation operators, modern data assimilation systems have the capability to ingest observations of quantities that are not themselves model variables, but are mathematically related to those variables. An example of this are the so-called LOS (line of sight) winds that a Doppler wind Lidar can provide. The model - or data assimilation system - needs information about both components of the horizontal wind vectors, whereas the observations in this case only provide the projection of the wind vector onto a given direction. The analyzed value is then calculated essentially based on a comparison between the observation itself and the model-simulated value of the observed quantity. However, in order to assess the expected impact of such an observing system, it is important to examine the extent to which a meteorological analysis can be constrained by the LOS winds. The answer to this question depends on the fundamental character of the atmospheric flow fields that are analyzed, but more importantly it also depends on the real and assumed error covariance characteristics of these fields. A single-level wind analysis system designed to explore these issues has been built at the NASA Data Assimilation Office. In this system, simulated wind observations can be evaluated in terms of their impact on the analysis quality under various assumptions about their spatial distribution and error characteristics and about the error covariance of the background fields. The basic design of the system will be presented along with experimental results obtained with it. In particular, the value of simultaneously measuring LOS winds along two different directions for a given location will be discussed.

  17. Impaired global, and compensatory local, biological motion processing in people with high levels of autistic traits.

    PubMed

    van Boxtel, Jeroen J A; Lu, Hongjing

    2013-01-01

    People with Autism Spectrum Disorder (ASD) are hypothesized to have poor high-level processing but superior low-level processing, causing impaired social recognition, and a focus on non-social stimulus contingencies. Biological motion perception provides an ideal domain to investigate exactly how ASD modulates the interaction between low and high-level processing, because it involves multiple processing stages, and carries many important social cues. We investigated individual differences among typically developing observers in biological motion processing, and whether such individual differences associate with the number of autistic traits. In Experiment 1, we found that individuals with fewer autistic traits were automatically and involuntarily attracted to global biological motion information, whereas individuals with more autistic traits did not show this pre-attentional distraction. We employed an action adaptation paradigm in the second study to show that individuals with more autistic traits were able to compensate for deficits in global processing with an increased involvement in local processing. Our findings can be interpreted within a predictive coding framework, which characterizes the functional relationship between local and global processing stages, and explains how these stages contribute to the perceptual difficulties associated with ASD.

  18. Impaired Global, and Compensatory Local, Biological Motion Processing in People with High Levels of Autistic Traits

    PubMed Central

    van Boxtel, Jeroen J. A.; Lu, Hongjing

    2013-01-01

    People with Autism Spectrum Disorder (ASD) are hypothesized to have poor high-level processing but superior low-level processing, causing impaired social recognition, and a focus on non-social stimulus contingencies. Biological motion perception provides an ideal domain to investigate exactly how ASD modulates the interaction between low and high-level processing, because it involves multiple processing stages, and carries many important social cues. We investigated individual differences among typically developing observers in biological motion processing, and whether such individual differences associate with the number of autistic traits. In Experiment 1, we found that individuals with fewer autistic traits were automatically and involuntarily attracted to global biological motion information, whereas individuals with more autistic traits did not show this pre-attentional distraction. We employed an action adaptation paradigm in the second study to show that individuals with more autistic traits were able to compensate for deficits in global processing with an increased involvement in local processing. Our findings can be interpreted within a predictive coding framework, which characterizes the functional relationship between local and global processing stages, and explains how these stages contribute to the perceptual difficulties associated with ASD. PMID:23630514

  19. Onsets of Solar Proton Events in Satellite and Ground Level Observations: A Comparison

    NASA Astrophysics Data System (ADS)

    He, Jing; Rodriguez, Juan V.

    2018-03-01

    The early detection of solar proton event onsets is essential for protecting humans and electronics in space, as well as passengers and crew at aviation altitudes. Two commonly compared methods for observing solar proton events that are sufficiently large and energetic to be detected on the ground through the creation of secondary radiation—known as ground level enhancements (GLEs)—are (1) a network of ground-based neutron monitors (NMs) and (2) satellite-based particle detectors. Until recently, owing to the different time resolution of the two data sets, it has not been feasible to compare these two types of observations using the same detection algorithm. This paper presents a comparison between the two observational platforms using newly processed >100 MeV 1 min count rates and fluxes from National Oceanic and Atmospheric Administration's Geostationary Operational Environmental Satellite (GOES) 8-12 satellites, and 1 min count rates from the Neutron Monitor Database. We applied the same detection algorithm to each data set (tuned to the different background noise levels of the instrument types). Seventeen SPEs with GLEs were studied: GLEs 55-70 from Solar Cycle 23 and GLE 71 from Solar Cycle 24. The median difference in the event detection times by GOES and NM data is 0 min, indicating no innate benefit in time of either system. The 10th, 25th, 75th, and 90th percentiles of the onset time differences (GOES minus NMs) are -7.2 min, -1.5 min, 2.5 min, and 4.2 min, respectively. This is in contrast to previous studies in which NM detections led GOES by 8 to 52 min without accounting for different alert protocols.

  20. Observation of high-temperature bubbles in an ECR plasma

    NASA Astrophysics Data System (ADS)

    Terasaka, K.; Yoshimura, S.; Tanaka, M. Y.

    2018-05-01

    Creation and annihilation of high-temperature bubbles have been observed in an electron cyclotron resonance plasma. The electron temperature in the bubble core is three times higher than that in the ambient region, and the size perpendicular to the magnetic field is much smaller than the plasma diameter. Formation of a bubble accompanies large negative spikes in the floating potential of a Langmuir probe, and the spatiotemporal behavior of the bubble has been visualized with a high-impedance wire grid detector. It is found that the bubble is in a prolate spheroidal shape with the axis along the magnetic field and occurs randomly in time and independently in space.

  1. Nocturnal low-level clouds over southern West Africa analysed using high-resolution simulations

    NASA Astrophysics Data System (ADS)

    Adler, Bianca; Kalthoff, Norbert; Gantner, Leonhard

    2017-01-01

    We performed a high-resolution numerical simulation to study the development of extensive low-level clouds that frequently form over southern West Africa during the monsoon season. This study was made in preparation for a field campaign in 2016 within the Dynamics-aerosol-chemistry-cloud interactions in West Africa (DACCIWA) project and focuses on an area around the city of Savè in southern Benin. Nocturnal low-level clouds evolve a few hundred metres above the ground around the same level as a distinct low-level jet. Several processes are found to determine the spatio-temporal evolution of these clouds including (i) significant cooling of the nocturnal atmosphere caused by horizontal advection with the south-westerly monsoon flow during the first half of the night, (ii) vertical cold air advection due to gravity waves leading to clouds in the wave crests and (iii) enhanced convergence and upward motion upstream of existing clouds that trigger new clouds. The latter is caused by an upward shift of the low-level jet in cloudy areas leading to horizontal convergence in the lower part and to horizontal divergence in the upper part of the cloud layer. Although this single case study hardly allows for a generalisation of the processes found, the results added to the optimisation of the measurements strategy for the field campaign and the observations will be used to test the hypotheses for cloud formation resulting from this study.

  2. Home safety practices in an urban low-income population: level of agreement between parental self-report and observed behaviors.

    PubMed

    Lee, Lois K; Walia, Taranjeev; Forbes, Peter W; Osganian, Stavroula K; Samuels, Ronald; Cox, Joanne E; Mooney, David P

    2012-12-01

    Home-related injuries are overrepresented in children from low-income households. The objectives of this study were to determine frequencies of home safety behaviors and the level of agreement between parental self-report and observed safety practices in low-income homes. In a prospective, interventional home injury prevention study of 49 low-income families with children <5 years old, a trained home visitor administered baseline parental home safety behavior questionnaires and assessments. There was high agreement between caregiver self-report and home visitor observation for lack of cabinet latch (99%, 95% confidence interval [CI] = 88%-99%) and stair gate use (100%, 95% CI = 88-100%). There was lower agreement for the safe storage of cleaning supplies (62%, 95% CI = 46%-75%), sharps (74%, 95% CI = 59%-85%), and medicines/vitamins (83%, 95% CI = 69%-92%) because of the overreporting of safe practices. Self-reports of some home safety behaviors are relatively accurate, but certain practices may need to be verified by direct assessment.

  3. Observational evidence for volcanic impact on sea level and the global water cycle

    PubMed Central

    Grinsted, A.; Moore, J. C.; Jevrejeva, S.

    2007-01-01

    It has previously been noted that there are drops in global sea level (GSL) after some major volcanic eruptions. However, observational evidence has not been convincing because there is substantial variability in the global sea level record over periods similar to those at which we expect volcanoes to have an impact. To quantify the impact of volcanic eruptions we average monthly GSL data from 830 tide gauge records around five major volcanic eruptions. Surprisingly, we find that the initial response to a volcanic eruption is a significant rise in sea level of 9 ± 3 mm in the first year after the eruption. This rise is followed by a drop of 7 ± 3 mm in the period 2–3 years after the eruption relative to preeruption sea level. These results are statistically robust and no particular volcanic eruption or ocean region dominates the signature we find. Neither the drop nor especially the rise in GSL can be explained by models of lower oceanic heat content. We suggest that the mechanism is a transient disturbance of the water cycle with a delayed response of land river runoff relative to ocean evaporation and global precipitation that affects global sea level. The volcanic impact on the water cycle and sea levels is comparable in magnitude to that of a large El Niño–La Niña cycle, amounting to ≈5% of global land precipitation. PMID:18056644

  4. Observational evidence for volcanic impact on sea level and the global water cycle.

    PubMed

    Grinsted, A; Moore, J C; Jevrejeva, S

    2007-12-11

    It has previously been noted that there are drops in global sea level (GSL) after some major volcanic eruptions. However, observational evidence has not been convincing because there is substantial variability in the global sea level record over periods similar to those at which we expect volcanoes to have an impact. To quantify the impact of volcanic eruptions we average monthly GSL data from 830 tide gauge records around five major volcanic eruptions. Surprisingly, we find that the initial response to a volcanic eruption is a significant rise in sea level of 9 +/- 3 mm in the first year after the eruption. This rise is followed by a drop of 7 +/- 3 mm in the period 2-3 years after the eruption relative to preeruption sea level. These results are statistically robust and no particular volcanic eruption or ocean region dominates the signature we find. Neither the drop nor especially the rise in GSL can be explained by models of lower oceanic heat content. We suggest that the mechanism is a transient disturbance of the water cycle with a delayed response of land river runoff relative to ocean evaporation and global precipitation that affects global sea level. The volcanic impact on the water cycle and sea levels is comparable in magnitude to that of a large El Niño-La Niña cycle, amounting to approximately 5% of global land precipitation.

  5. High C-reactive protein levels are associated with depressive symptoms in schizophrenia.

    PubMed

    Faugere, M; Micoulaud-Franchi, J-A; Faget-Agius, C; Lançon, C; Cermolacce, M; Richieri, R

    2018-01-01

    Depressive symptoms are frequently associated with schizophrenia symptoms. C - Reactive protein (CRP), a marker of chronic inflammation, had been found elevated in patients with schizophrenia and in patients with depressive symptoms. However, the association between CRP level and depressive symptoms has been poorly investigated in patients with schizophrenia. The only study conducted found an association between high CRP levels and antidepressant consumption, but not with depressive symptoms investigated with the Calgary Depression Rating Scale for Schizophrenia (CDSS). The aim of this study was to evaluate CRP levels and depressive symptoms in patients with schizophrenia, and to determine whether high CRP levels are associated with depressive symptoms and/or antidepressant consumption, independently of potential confounding factors, especially tobacco-smoking and metabolic syndrome. Three hundred and seven patients with schizophrenia were enrolled in this study (mean age = 35.74 years, 69.1% male gender). Depressive symptoms was investigated with the CDSS. Patients were classified in two groups: normal CRP level (≤ 3.0mg/L) and high CRP level (> 3.0mg/L). Current medication was recorded. 124 subjects (40.4%) were classified in the high CRP level group. After adjusting for confounding factors, these patients were found to have higher CDSS scores than those with normal CRP levels in multivariate analyses (p = 0.035, OR = 1.067, 95% CI = 1.004-1.132). No significant association between CRP levels and antidepressants consumption was found. The size sample is relatively small. The cut-off point for high cardiovascular risk was used to define the two groups. CRP was the sole marker of inflammation in this study and was collected at only one time point. The design of this study is cross-sectional and there are no conclusions about the directionality of the association between depression and inflammation in schizophrenia. This study found an association between high

  6. Ga(+) Basicity and Affinity Scales Based on High-Level Ab Initio Calculations.

    PubMed

    Brea, Oriana; Mó, Otilia; Yáñez, Manuel

    2015-10-26

    The structure, relative stability and bonding of complexes formed by the interaction between Ga(+) and a large set of compounds, including hydrocarbons, aromatic systems, and oxygen-, nitrogen-, fluorine and sulfur-containing Lewis bases have been investigated through the use of the high-level composite ab initio Gaussian-4 theory. This allowed us to establish rather accurate Ga(+) cation affinity (GaCA) and Ga(+) cation basicity (GaCB) scales. The bonding analysis of the complexes under scrutiny shows that, even though one of the main ingredients of the Ga(+) -base interaction is electrostatic, it exhibits a non-negligible covalent character triggered by the presence of the low-lying empty 4p orbital of Ga(+) , which favors a charge donation from occupied orbitals of the base to the metal ion. This partial covalent character, also observed in AlCA scales, is behind the dissimilarities observed when GaCA are compared with Li(+) cation affinities, where these covalent contributions are practically nonexistent. Quite unexpectedly, there are some dissimilarities between several Ga(+) -complexes and the corresponding Al(+) -analogues, mainly affecting the relative stability of π-complexes involving aromatic compounds. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Investigating the Influence of Anthropogenic Forcing on Observed Mean and Extreme Sea Level Pressure Trends over the Mediterranean Region

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barkhordarian, Armineh

    We investigate whether the observed mean sea level pressure (SLP) trends over the Mediterranean region in the period from 1975 to 2004 are significantly consistent with what 17 models projected as response of SLP to anthropogenic forcing (greenhouse gases and sulphate aerosols, GS). Obtained results indicate that the observed trends in mean SLP cannot be explained by natural (internal) variability. Externally forced changes are detectable in all seasons, except spring. The large-scale component (spatial mean) of the GS signal is detectable in all the 17 models in winter and in 12 of the 17 models in summer. However, the small-scalemore » component (spatial anomalies about the spatial mean) of GS signal is only detectable in winter within 11 of the 17 models. We also show that GS signal has a detectable influence on observed decreasing (increasing) tendency in the frequencies of extremely low (high) SLP days in winter and that these changes cannot be explained by internal climate variability. While the detection of GS forcing is robust in winter and summer, there are striking inconsistencies in autumn, where analysis points to the presence of an external forcing, which is not GS forcing.« less

  8. Investigating the Influence of Anthropogenic Forcing on Observed Mean and Extreme Sea Level Pressure Trends over the Mediterranean Region

    DOE PAGES

    Barkhordarian, Armineh

    2012-01-01

    We investigate whether the observed mean sea level pressure (SLP) trends over the Mediterranean region in the period from 1975 to 2004 are significantly consistent with what 17 models projected as response of SLP to anthropogenic forcing (greenhouse gases and sulphate aerosols, GS). Obtained results indicate that the observed trends in mean SLP cannot be explained by natural (internal) variability. Externally forced changes are detectable in all seasons, except spring. The large-scale component (spatial mean) of the GS signal is detectable in all the 17 models in winter and in 12 of the 17 models in summer. However, the small-scalemore » component (spatial anomalies about the spatial mean) of GS signal is only detectable in winter within 11 of the 17 models. We also show that GS signal has a detectable influence on observed decreasing (increasing) tendency in the frequencies of extremely low (high) SLP days in winter and that these changes cannot be explained by internal climate variability. While the detection of GS forcing is robust in winter and summer, there are striking inconsistencies in autumn, where analysis points to the presence of an external forcing, which is not GS forcing.« less

  9. High-resolution study of levels in the astrophysically important nucleus 26Mg and resulting updated level assignments

    NASA Astrophysics Data System (ADS)

    Adsley, P.; Brümmer, J. W.; Faestermann, T.; Fox, S. P.; Hammache, F.; Hertenberger, R.; Meyer, A.; Neveling, R.; Seiler, D.; de Séréville, N.; Wirth, H.-F.

    2018-04-01

    Background: The 22Ne(α ,n )25Mg reaction is an important source of neutrons for the s -process. Direct measurement of this reaction and the competing 22Ne(α ,γ )26Mg reaction are challenging due to the gaseous nature of both reactants, the low cross section and the experimental challenges of detecting neutrons and high-energy γ rays. Detailed knowledge of the resonance properties enables the rates to be constrained for s -process models. Purpose: Previous experimental studies have demonstrated a lack of agreement in both the number and excitation energy of levels in 26Mg. To try to resolve the disagreement between different experiments, proton and deuteron inelastic scattering from 26Mg have been used to identify excited states. Method: Proton and deuteron beams from the tandem accelerator at the Maier-Leibnitz Laboratorium at Garching, Munich, were incident upon enriched 26MgO targets. Scattered particles were momentum-analyzed in the Q3D magnetic spectrograph and detected at the focal plane. Results: Reassignments of states around Ex=10.8 -10.83 MeV in 26Mg suggested in previous works have been confirmed. In addition, new states in 26Mg have been observed, two below and two above the neutron threshold. Up to six additional states above the neutron threshold may have been observed compared to experimental studies of neutron reactions on 25Mg, but some or all of these states may be due to 24Mg contamination in the target. Finally, inconsistencies between measured resonance strengths and some previously accepted Jπ assignments of excited 26Mg states have been noted. Conclusion: There are still a large number of nuclear properties in 26Mg that have yet to be determined and levels that are, at present, not included in calculations of the reaction rates. In addition, some inconsistencies between existing nuclear data exist that must be resolved in order for the reaction rates to be properly calculated.

  10. Marine Boundary Layer Cloud Property Retrievals from High-Resolution ASTER Observations: Case Studies and Comparison with Terra MODIS

    NASA Technical Reports Server (NTRS)

    Werner, Frank; Wind, Galina; Zhang, Zhibo; Platnick, Steven; Di Girolamo, Larry; Zhao, Guangyu; Amarasinghe, Nandana; Meyer, Kerry

    2016-01-01

    A research-level retrieval algorithm for cloud optical and microphysical properties is developed for the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) aboard the Terra satellite. It is based on the operational MODIS algorithm. This paper documents the technical details of this algorithm and evaluates the retrievals for selected marine boundary layer cloud scenes through comparisons with the operational MODIS Data Collection 6 (C6) cloud product. The newly developed, ASTERspecific cloud masking algorithm is evaluated through comparison with an independent algorithm reported in Zhao and Di Girolamo (2006). To validate and evaluate the cloud optical thickness (tau) and cloud effective radius (r(sub eff)) from ASTER, the high-spatial-resolution ASTER observations are first aggregated to the same 1000m resolution as MODIS. Subsequently, tau(sub aA) and r(sub eff, aA) retrieved from the aggregated ASTER radiances are compared with the collocated MODIS retrievals. For overcast pixels, the two data sets agree very well with Pearson's product-moment correlation coefficients of R greater than 0.970. However, for partially cloudy pixels there are significant differences between r(sub eff, aA) and the MODIS results which can exceed 10 micrometers. Moreover, it is shown that the numerous delicate cloud structures in the example marine boundary layer scenes, resolved by the high-resolution ASTER retrievals, are smoothed by the MODIS observations. The overall good agreement between the research-level ASTER results and the operational MODIS C6 products proves the feasibility of MODIS-like retrievals from ASTER reflectance measurements and provides the basis for future studies concerning the scale dependency of satellite observations and three-dimensional radiative effects.

  11. Marine boundary layer cloud property retrievals from high-resolution ASTER observations: case studies and comparison with Terra MODIS

    NASA Astrophysics Data System (ADS)

    Werner, Frank; Wind, Galina; Zhang, Zhibo; Platnick, Steven; Di Girolamo, Larry; Zhao, Guangyu; Amarasinghe, Nandana; Meyer, Kerry

    2016-12-01

    A research-level retrieval algorithm for cloud optical and microphysical properties is developed for the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) aboard the Terra satellite. It is based on the operational MODIS algorithm. This paper documents the technical details of this algorithm and evaluates the retrievals for selected marine boundary layer cloud scenes through comparisons with the operational MODIS Data Collection 6 (C6) cloud product. The newly developed, ASTER-specific cloud masking algorithm is evaluated through comparison with an independent algorithm reported in [Zhao and Di Girolamo(2006)]. To validate and evaluate the cloud optical thickness (τ) and cloud effective radius (reff) from ASTER, the high-spatial-resolution ASTER observations are first aggregated to the same 1000 m resolution as MODIS. Subsequently, τaA and reff, aA retrieved from the aggregated ASTER radiances are compared with the collocated MODIS retrievals. For overcast pixels, the two data sets agree very well with Pearson's product-moment correlation coefficients of R > 0.970. However, for partially cloudy pixels there are significant differences between reff, aA and the MODIS results which can exceed 10 µm. Moreover, it is shown that the numerous delicate cloud structures in the example marine boundary layer scenes, resolved by the high-resolution ASTER retrievals, are smoothed by the MODIS observations. The overall good agreement between the research-level ASTER results and the operational MODIS C6 products proves the feasibility of MODIS-like retrievals from ASTER reflectance measurements and provides the basis for future studies concerning the scale dependency of satellite observations and three-dimensional radiative effects.

  12. High-level waste program progress report, April 1, 1980-June 30, 1980

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1980-08-01

    The highlights of this report are on: waste management analysis for nuclear fuel cycles; fixation of waste in concrete; study of ceramic and cermet waste forms; alternative high-level waste forms development; and high-level waste container development.

  13. The Effect of Residing Altitude on Levels of High-Density Lipoprotein Cholesterol: A Pilot Study From the Omani Arab Population.

    PubMed

    Al Riyami, Nafila B; Banerjee, Yajnavalka; Al-Waili, Khalid; Rizvi, Syed G; Al-Yahyaee, Said; Hassan, Mohammed O; Albarwani, Sulayma; Al-Rasadi, Khalid; Bayoumi, Riad A

    2015-07-01

    Lower mortality rates from coronary heart disease and higher levels of serum high-density lipoprotein cholesterol (HDL-C) have been observed in populations residing at high altitude. However, this effect has not been investigated in Arab populations, which exhibit considerable genetic homogeneity. We assessed the relationship between residing altitude and HDL-C in 2 genetically similar Omani Arab populations residing at different altitudes. The association between the levels of HDL-C and other metabolic parameters was also investigated. The levels of HDL-C were significantly higher in the high-altitude group compared with the low-altitude group. Stepwise regression analysis showed that altitude was the most significant factor affecting HDL-C, followed by gender, serum triglycerides, and finally the 2-hour postprandial plasma glucose. This finding is consistent with previously published studies from other populations and should be taken into consideration when comparing cardiovascular risk factors in populations residing at different altitudes. © The Author(s) 2014.

  14. The Yo-Yo intermittent recovery test level 1 is reliable in young high-level soccer players.

    PubMed

    Deprez, D; Fransen, J; Lenoir, M; Philippaerts, Rm; Vaeyens, R

    2015-03-01

    The aim of the study was to investigate test reliability of the Yo-Yo intermittent recovery test level 1 (YYIR1) in 36 high-level youth soccer players, aged between 13 and 18 years. Players were divided into three age groups (U15, U17 and U19) and completed three YYIR1 in three consecutive weeks. Pairwise comparisons were used to investigate test reliability (for distances and heart rate responses) using technical error (TE), coefficient of variation (CV), intra-class correlation (ICC) and limits of agreement (LOA) with Bland-Altman plots. The mean YYIR1 distances for the U15, U17 and U19 groups were 2024 ± 470 m, 2404 ± 347 m and 2547 ± 337 m, respectively. The results revealed that the TEs varied between 74 and 172 m, CVs between 3.0 and 7.5%, and ICCs between 0.87 and 0.95 across all age groups for the YYIR1 distance. For heart rate responses, the TEs varied between 1 and 6 bpm, CVs between 0.7 and 4.8%, and ICCs between 0.73 and 0.97. The small ratio LOA revealed that any two YYIR1 performances in one week will not differ by more than 9 to 28% due to measurement error. In summary, the YYIR1 performance and the physiological responses have proven to be highly reliable in a sample of Belgian high-level youth soccer players, aged between 13 and 18 years. The demonstrated high level of intermittent endurance capacity in all age groups may be used for comparison of other prospective young soccer players.

  15. High infestation levels of Schizotetranychus oryzae severely affects rice metabolism.

    PubMed

    Blasi, Édina A R; Buffon, Giseli; Rativa, Angie G S; Lopes, Mara C B; Berger, Markus; Santi, Lucélia; Lavallée-Adam, Mathieu; Yates, John R; Schwambach, Joséli; Beys-da-Silva, Walter O; Sperotto, Raul A

    2017-12-01

    High levels of Schizotetranychus oryzae phytophagous mite infestation on rice leaves can severely affect productivity. Physiological characterization showed that S. oryzae promotes a decrease in chlorophyll concentration and the establishment of a senescence process in rice leaves. Late-infested leaves also present high levels of superoxide radical and hydrogen peroxide accumulation, along with high levels of membrane integrity loss, which is indicative of cell death. To better understand the rice molecular responses to high levels of mite infestation, we employed the Multidimensional Protein Identification Technology (MudPIT) approach to identify differentially expressed proteins. We identified 83 and 88 proteins uniquely present in control and late-infested leaves, respectively, along with 11 and one proteins more abundant in control and late-infested leaves, respectively. S. oryzae infestation induces a decreased abundance of proteins related to translation, protease inhibition, and photosynthesis. On the other hand, infestation caused increased abundance of proteins involved in protein modification and degradation. Our results also suggest that S. oryzae infestation interferes with intracellular transport, DNA structure maintenance, and amino acid and lipid metabolism in rice leaves. Proteomic data were positively correlated with enzymatic assays and RT-qPCR analysis. Our findings describe the protein expression patterns of late-infested rice leaves and suggest several targets which could be tested in future biotechnological approaches aiming to avoid the population increase of phytophagous mite in rice plants. Copyright © 2017 Elsevier GmbH. All rights reserved.

  16. High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1

    PubMed Central

    Peñate, Xenia; Sanmartín Olmo, Trinidad; Jourquin, Frederic; Muñoz Centeno, Maria Cruz; Mendoza, Manuel; Simon, Marie-Noelle; Chavez, Sebastian

    2018-01-01

    Whole-genome duplications (WGDs) have played a central role in the evolution of genomes and constitute an important source of genome instability in cancer. Here, we show in Saccharomyces cerevisiae that abnormal accumulations of histones are sufficient to induce WGDs. Our results link these WGDs to a reduced incorporation of the histone variant H2A.Z to chromatin. Moreover, we show that high levels of histones promote Swe1WEE1 stabilisation thereby triggering the phosphorylation and inhibition of Cdc28CDK1 through a mechanism different of the canonical DNA damage response. Our results link high levels of histones to a specific type of genome instability that is quite frequently observed in cancer and uncovers a new mechanism that might be able to respond to high levels of histones. PMID:29580382

  17. Observation of finite-wavelength screening in high-energy-density matter

    DOE PAGES

    Chapman, D. A.; Vorberger, J.; Fletcher, L. B.; ...

    2015-04-23

    A key component for the description of charged particle systems is the screening of the Coulomb interaction between charge carriers. First investigated in the 1920s by Debye and Hückel for electrolytes, charge screening is important for determining the structural and transport properties of matter as diverse as astrophysical and laboratory plasmas, nuclear matter such as quark-gluon plasmas, electrons in solids, planetary cores and charged macromolecules. For systems with negligible dynamics, screening is still mostly described using a Debye–Hückel-type approach. Here, we report the novel observation of a significant departure from the Debye–Hückel-type model in high-energy-density matter by probing laser-driven, shock-compressedmore » plastic with high-energy X-rays. We use spectrally resolved X-ray scattering in a geometry that enables direct investigation of the screening cloud, and demonstrate that the observed elastic scattering amplitude is only well described within a more general approach.« less

  18. High Frequency Radar Observations of Tidal Current Variability in the Lower Chesapeake Bay

    NASA Astrophysics Data System (ADS)

    Updyke, T. G.; Dusek, G.; Atkinson, L. P.

    2016-02-01

    Analysis of eight years of high frequency radar surface current observations in the lower Chesapeake Bay is presented with a focus on the variability of the tidal component of the surface circulation which accounts for a majority of the variance of the surface flow (typically 70-80% for the middle of the radar footprint). Variations in amplitude and phase of the major tidal constituents are examined in the context of water level, wind and river discharge data. Comparisons are made with harmonic analysis results from long-term records of current data measured by three current profilers operated by NOAA as part of the Chesapeake Bay Physical Oceanographic Real-Time System (PORTS). Preliminary results indicate that there is significant spatial variability in the M2 amplitude over the HF radar grid as well as temporal variability when harmonic analysis is performed using bi-monthly time segments over the course of the record.

  19. High-level expression of Camelid nanobodies in Nicotiana benthamiana.

    PubMed

    Teh, Yi-Hui Audrey; Kavanagh, Tony A

    2010-08-01

    Nanobodies (or VHHs) are single-domain antigen-binding fragments derived from Camelid heavy chain-only antibodies. Their small size, monomeric behaviour, high stability and solubility, and ability to bind epitopes not accessible to conventional antibodies make them especially suitable for many therapeutic and biotechnological applications. Here we describe high-level expression, in Nicotiana benthamiana, of three versions of an anti-hen egg white lysozyme (HEWL) nanobody which include the original VHH from an immunized library (cAbLys3), a codon-optimized derivative, and a codon-optimized hybrid nanobody comprising the CDRs of cAbLys3 grafted onto an alternative 'universal' nanobody framework. His6- and StrepII-tagged derivatives of each nanobody were targeted for accumulation in the cytoplasm, chloroplast and apoplast using different pre-sequences. When targeted to the apoplast, intact functional nanobodies accumulated at an exceptionally high level (up to 30% total leaf protein), demonstrating the great potential of plants as a nanobody production system.

  20. High-security communication by coherence modulation at the photon-counting level.

    PubMed

    Rhodes, William T; Boughanmi, Abdellatif; Moreno, Yezid Torres

    2016-05-20

    We show that key-specified interferometer path-length difference modulation (often referred to as coherence modulation), operating in the photon-counting regime with a broadband source, can provide a quantifiably high level of physics-guaranteed security for binary signal transmission. Each signal bit is associated with many photocounts, perhaps numbering in the thousands. Of great importance, the presence of an eavesdropper can be quickly detected. We first review the operation of key-specified coherence modulation at high light levels, illustrating by means of an example its lack of security against attack. We then show, using the same example, that, through the reduction of light intensities to photon-counting levels, a high level of security can be attained. A particular attack on the system is analyzed to demonstrate the quantifiability of the scheme's security, and various remaining research issues are discussed. A potential weakness of the scheme lies in a possible vulnerability to light amplification by an attacker.

  1. High Level Information Fusion (HLIF) with nested fusion loops

    NASA Astrophysics Data System (ADS)

    Woodley, Robert; Gosnell, Michael; Fischer, Amber

    2013-05-01

    Situation modeling and threat prediction require higher levels of data fusion in order to provide actionable information. Beyond the sensor data and sources the analyst has access to, the use of out-sourced and re-sourced data is becoming common. Through the years, some common frameworks have emerged for dealing with information fusion—perhaps the most ubiquitous being the JDL Data Fusion Group and their initial 4-level data fusion model. Since these initial developments, numerous models of information fusion have emerged, hoping to better capture the human-centric process of data analyses within a machine-centric framework. 21st Century Systems, Inc. has developed Fusion with Uncertainty Reasoning using Nested Assessment Characterizer Elements (FURNACE) to address challenges of high level information fusion and handle bias, ambiguity, and uncertainty (BAU) for Situation Modeling, Threat Modeling, and Threat Prediction. It combines JDL fusion levels with nested fusion loops and state-of-the-art data reasoning. Initial research has shown that FURNACE is able to reduce BAU and improve the fusion process by allowing high level information fusion (HLIF) to affect lower levels without the double counting of information or other biasing issues. The initial FURNACE project was focused on the underlying algorithms to produce a fusion system able to handle BAU and repurposed data in a cohesive manner. FURNACE supports analyst's efforts to develop situation models, threat models, and threat predictions to increase situational awareness of the battlespace. FURNACE will not only revolutionize the military intelligence realm, but also benefit the larger homeland defense, law enforcement, and business intelligence markets.

  2. A High-Level Language for Modeling Algorithms and Their Properties

    NASA Astrophysics Data System (ADS)

    Akhtar, Sabina; Merz, Stephan; Quinson, Martin

    Designers of concurrent and distributed algorithms usually express them using pseudo-code. In contrast, most verification techniques are based on more mathematically-oriented formalisms such as state transition systems. This conceptual gap contributes to hinder the use of formal verification techniques. Leslie Lamport introduced PlusCal, a high-level algorithmic language that has the "look and feel" of pseudo-code, but is equipped with a precise semantics and includes a high-level expression language based on set theory. PlusCal models can be compiled to TLA + and verified using the model checker tlc.

  3. Lyman-Alpha Observations of High Radial Velocity Stars

    NASA Astrophysics Data System (ADS)

    Bookbinder, Jay

    1990-12-01

    H I LYMAN -ALPHA (LY-A) IS ONE OF THE MOST IMPORTANT LINES EMITTED BY PLASMA IN THE TEMPERATURE RANGE OF 7000 TO 10 TO THE FIFTH POWER K IN LATE-TYPE STARS. IT IS A MAJOR COMPONENT OF THE TOTAL RADIATIVE LOSS RATE, AND IT PLAYS A CRUCIAL ROLE IN DETERMINING THE ATMOSPHERIC STRUCTURE AND IN FLUORESCING OTHER UV LINES. YET IT IS ALSO THE LEAST STUDIED MAJOR LINE IN THE FAR UV, BECAUSE MOST OF THE LINE FLUX IS ABSORBED BY THE ISM ALONG THE LINE OF SIGHT AND BECAUSE IT IS STRONGLY COMTAMINATED BY THE GEOCORONAL BACKGROUND. A KNOWLEDGE OF THE Ly-A PROFILE IS ALSO IMPORTANT FOR STUDIES OF DEUTERIUM IN THE INTERSTELLAR MEDIUM. BY OBSERVING HIGH RADIAL VELOCITY STARS WE WILL OBTAIN FOR THE FIRST TIME HIGH RESOLUTION SPECTRA OF THE CORE OF A STELLAR H I LYMAN-A EMISSION LINE PROFILE.

  4. Analysis of Ultra High Resolution Sea Surface Temperature Level 4 Datasets

    NASA Technical Reports Server (NTRS)

    Wagner, Grant

    2011-01-01

    Sea surface temperature (SST) studies are often focused on improving accuracy, or understanding and quantifying uncertainties in the measurement, as SST is a leading indicator of climate change and represents the longest time series of any ocean variable observed from space. Over the past several decades SST has been studied with the use of satellite data. This allows a larger area to be studied with much more frequent measurements being taken than direct measurements collected aboard ship or buoys. The Group for High Resolution Sea Surface Temperature (GHRSST) is an international project that distributes satellite derived sea surface temperatures (SST) data from multiple platforms and sensors. The goal of the project is to distribute these SSTs for operational uses such as ocean model assimilation and decision support applications, as well as support fundamental SST research and climate studies. Examples of near real time applications include hurricane and fisheries studies and numerical weather forecasting. The JPL group has produced a new 1 km daily global Level 4 SST product, the Multiscale Ultrahigh Resolution (MUR), that blends SST data from 3 distinct NASA radiometers: the Moderate Resolution Imaging Spectroradiometer (MODIS), the Advanced Very High Resolution Radiometer (AVHRR), and the Advanced Microwave Scanning Radiometer ? Earth Observing System(AMSRE). This new product requires further validation and accuracy assessment, especially in coastal regions.We examined the accuracy of the new MUR SST product by comparing the high resolution version and a lower resolution version that has been smoothed to 19 km (but still gridded to 1 km). Both versions were compared to the same data set of in situ buoy temperature measurements with a focus on study regions of the oceans surrounding North and Central America as well as two smaller regions around the Gulf Stream and California coast. Ocean fronts exhibit high temperature gradients (Roden, 1976), and thus

  5. Teen Dating Violence Victimization Among High School Students: A Multilevel Analysis of School-Level Risk Factors.

    PubMed

    Parker, Elizabeth M; Johnson, Sarah Lindstrom; Debnam, Katrina J; Milam, Adam J; Bradshaw, Catherine P

    2017-09-01

    Much etiologic research has focused on individual-level risk factors for teen dating violence (TDV); therefore, less is known about school-level and neighborhood-level risk factors. We examined the association between alcohol outlet density around high schools and TDV victimization and the association between markers of physical disorder around schools and TDV victimization among adolescents. Data come from high school students participating in the Maryland Safe and Supportive Schools Initiative. Alcohol outlet density was calculated using walking distance buffers around schools. An observational tool was used to assess indicators of physical disorder on school property (eg, alcohol and drug paraphernalia). Hierarchical linear modeling was used to identify student- and school-level predictors associated with TDV victimization. Overall, 11% of students reported experiencing physical TDV and 11% reported experiencing psychological TDV over the past year. Recent alcohol use was a risk factor for TDV victimization for both sexes, whereas feeling safe at school was protective against TDV victimization for both sexes. Greater alcohol outlet density was associated with decreased TDV victimization for males, however, it was nonsignificant for females. Physical disorder around schools was not associated with TDV victimization for either sex. Although the school-level predictors were not associated with TDV victimization, alcohol use and perceptions of safety at school were significantly associated with TDV victimization. Prevention efforts to address alcohol use may affect TDV victimization. © 2017, American School Health Association.

  6. High-Speed Camera and High-Vision Camera Observations of TLEs from Jet Aircraft in Winter Japan and in Summer US

    NASA Astrophysics Data System (ADS)

    Sato, M.; Takahashi, Y.; Kudo, T.; Yanagi, Y.; Kobayashi, N.; Yamada, T.; Project, N.; Stenbaek-Nielsen, H. C.; McHarg, M. G.; Haaland, R. K.; Kammae, T.; Cummer, S. A.; Yair, Y.; Lyons, W. A.; Ahrns, J.; Yukman, P.; Warner, T. A.; Sonnenfeld, R. G.; Li, J.; Lu, G.

    2011-12-01

    The time evolution and spatial distributions of transient luminous events (TLEs) are the key parameters to identify the relationship between TLEs and parent lightning discharges, roles of electromagnetic pulses (EMPs) emitted by horizontal and vertical lightning currents in the formation of TLEs, and the occurrence condition and mechanisms of TLEs. Since the time scales of TLEs is typically less than a few milliseconds, new imaging technique that enable us to capture images with a high time resolution of < 1ms is awaited. By courtesy of "Cosmic Shore" Project conducted by Japan Broadcasting Corporation (NHK), we have carried out optical observations using a high-speed Image-Intensified (II) CMOS camera and a high-vision three-CCD camera from a jet aircraft on November 28 and December 3, 2010 in winter Japan. Using the high-speed II-CMOS camera, it is possible to capture images with 8,300 frames per second (fps), which corresponds to the time resolution of 120 us. Using the high-vision three-CCD camera, it is possible to capture high quality, true color images of TLEs with a 1920x1080 pixel size and with a frame rate of 30 fps. During the two observation flights, we have succeeded to detect 28 sprite events, and 3 elves events totally. In response to this success, we have conducted a combined aircraft and ground-based campaign of TLE observations at the High Plains in summer US. We have installed same NHK high-speed and high-vision cameras in a jet aircraft. In the period from June 27 and July 10, 2011, we have operated aircraft observations in 8 nights, and we have succeeded to capture TLE images for over a hundred events by the high-vision camera and succeeded to acquire over 40 high-speed images simultaneously. At the presentation, we will introduce the outlines of the two aircraft campaigns, and will introduce the characteristics of the time evolution and spatial distributions of TLEs observed in winter Japan, and will show the initial results of high

  7. Mapping auditory nerve firing density using high-level compound action potentials and high-pass noise masking a

    PubMed Central

    Earl, Brian R.; Chertoff, Mark E.

    2012-01-01

    Future implementation of regenerative treatments for sensorineural hearing loss may be hindered by the lack of diagnostic tools that specify the target(s) within the cochlea and auditory nerve for delivery of therapeutic agents. Recent research has indicated that the amplitude of high-level compound action potentials (CAPs) is a good predictor of overall auditory nerve survival, but does not pinpoint the location of neural damage. A location-specific estimate of nerve pathology may be possible by using a masking paradigm and high-level CAPs to map auditory nerve firing density throughout the cochlea. This initial study in gerbil utilized a high-pass masking paradigm to determine normative ranges for CAP-derived neural firing density functions using broadband chirp stimuli and low-frequency tonebursts, and to determine if cochlear outer hair cell (OHC) pathology alters the distribution of neural firing in the cochlea. Neural firing distributions for moderate-intensity (60 dB pSPL) chirps were affected by OHC pathology whereas those derived with high-level (90 dB pSPL) chirps were not. These results suggest that CAP-derived neural firing distributions for high-level chirps may provide an estimate of auditory nerve survival that is independent of OHC pathology. PMID:22280596

  8. A note on sea level variability at Clipperton Island from GEOSAT and in-situ observations

    NASA Astrophysics Data System (ADS)

    Maul, George A.; Hansen, Donald V.; Bravo, Nicolas J.

    During the 1986-1989 Exact Repeat Mission (ERM) of GEOSAT, in-situ observations of sea level at Clipperton Island (10°N/109°W) and satellite-tracked free-drifting drogued buoys in the eastern tropical Pacific Ocean are concurrently available. A map of the standard deviations of GEOSAT sea surface heights (2.9 years) shows a variance maximum along ˜12°N from Central America, past Clipperton to ˜160°W. Sea floor pressure gauge observations from a shallow (10m depth) site on Clipperton Island and an ERM crossover point in deep water nearby show a correlation of r = 0.76 with a residual of ±6.7 cm RMS. Approximately 17% of the difference (GEOSAT minus sea level) is characterized by a 4 cm amplitude 0° phase annual harmonic, which is probably caused by unaccounted-for tropospheric water vapor affecting the altimeter and/or ERM orbit error removal. Wintertime anticyclonic mesoscale eddies advecting past Clipperton Island each year have GEOSAT sea surface height and in-situ sea level signals of more than 30 cm, some of which are documented by the satellite-tracked drifters. Meridional profiles of the annual harmonic of zonal geostrophic current from GEOSAT and from the drifters both show synchronous maxima in the North Equatorial Countercurrent and the North Equatorial Current. Other Clipperton sea level maxima seen during late spring of each year may involve anticyclonic vortices formed along Central America the previous winter.

  9. Mass-induced sea level variations in the Red Sea from GRACE, steric-corrected altimetry, in situ bottom pressure records, and hydrographic observations

    NASA Astrophysics Data System (ADS)

    Feng, W.; Lemoine, J.-M.; Zhong, M.; Hsu, H. T.

    2014-08-01

    An annual amplitude of ∼18 cm mass-induced sea level variations (SLV) in the Red Sea is detected from the Gravity Recovery and Climate Experiment (GRACE) satellites and steric-corrected altimetry from 2003 to 2011. The annual mass variations in the region dominate the mean SLV, and generally reach maximum in late January/early February. The annual steric component of the mean SLV is relatively small (<3 cm) and out of phase of the mass-induced SLV. In situ bottom pressure records at the eastern coast of the Red Sea validate the high mass variability observed by steric-corrected altimetry and GRACE. In addition, the horizontal water mass flux of the Red Sea estimated from GRACE and steric-corrected altimetry is validated by hydrographic observations.

  10. Inter-observer variability in diagnosing radiological features of aneurysmal subarachnoid hemorrhage; a preliminary single centre study comparing observers from different specialties and levels of training.

    PubMed

    Siddiqui, Usman T; Khan, Anjum F; Shamim, Muhammad Shahzad; Hamid, Rana Shoaib; Alam, Muhammad Mehboob; Emaduddin, Muhammad

    2014-01-01

    A noncontrast computed tomography (CT) scan remains the initial radiological investigation of choice for a patient with suspected aneurysmal subarachnoid hemorrhage (aSAH). This initial scan may be used to derive key information about the underlying aneurysm which may aid in further management. The interpretation, however, is subject to the skill and experience of the interpreting individual. The authors here evaluate the interpretation of such CT scans by different individuals at different levels of training, and in two different specialties (Radiology and Neurosurgery). Initial nonontrast CT scan of 35 patients with aSAH was evaluated independently by four different observers. The observers selected for the study included two from Radiology and two from Neurosurgery at different levels of training; a resident currently in mid training and a resident who had recently graduated from training of each specialty. Measured variables included interpreter's suspicion of presence of subarachnoid blood, side of the subarachnoid hemorrhage, location of the aneurysm, the aneurysm's proximity to vessel bifurcation, number of aneurysm(s), contour of aneurysm(s), presence of intraventricular hemorrhage (IVH), intracerebral hemorrhage (ICH), infarction, hydrocephalus and midline shift. To determine the inter-observer variability (IOV), weighted kappa values were calculated. There was moderate agreement on most of the CT scan findings among all observers. Substantial agreement was found amongst all observers for hydrocephalus, IVH, and ICH. Lowest agreement rates were seen in the location of aneurysm being supra or infra tentorial. There were, however, some noteworthy exceptions. There was substantial to almost perfect agreement between the radiology graduate and radiology resident on most CT findings. The lowest agreement was found between the neurosurgery graduate and the radiology graduate. Our study suggests that although agreements were seen in the interpretation of some of

  11. Spectrum-agile hundred-watt-level high-power random fiber laser enabled by watt-level tunable optical filter

    NASA Astrophysics Data System (ADS)

    Ye, Jun; Xu, Jiangming; Song, Jiaxin; Wu, Hanshuo; Zhang, Hanwei; Wu, Jian; Zhou, Pu

    2018-06-01

    Through high-fidelity numerical modeling and careful system-parameter design, we demonstrate the spectral manipulation of a hundred-watt-level high-power random fiber laser (RFL) by employing a watt-level tunable optical filter. Consequently, a >100-W RFL with the spectrum-agile property is achieved. The central wavelength can be continuously tuned with a range of ∼20 nm, and the tuning range of the full width at half maximum linewidth, which is closely related to the central wavelength, covers ∼1.1 to ∼2.7 times of the minimum linewidth.

  12. Observation of Dust Stream Formation Produced by Low Current, High Voltage Cathode Spots

    NASA Technical Reports Server (NTRS)

    Foster, John E.

    2004-01-01

    Macro-particle acceleration driven by low current, high voltage cathode spots has been investigated. The phenomenon was observed to occur when nanometer and micrometer-sized particles in the presence of a discharge plasma were exposed to a high voltage pulse. The negative voltage pulse initiates the formation of multiple, high voltage, low current cathode spots which provides the mechanism of actual acceleration of the charged dust particles. Dust streams generated by this process were detected using laser scattering techniques. The particle impact craters observed at the surface of downstream witness badges were documented using SEM and light microscopy.

  13. Interventions for Individuals With High Levels of Needle Fear

    PubMed Central

    Noel, Melanie; Taddio, Anna; Antony, Martin M.; Asmundson, Gordon J.G.; Riddell, Rebecca Pillai; Chambers, Christine T.; Shah, Vibhuti

    2015-01-01

    Background: This systematic review evaluated the effectiveness of exposure-based psychological and physical interventions for the management of high levels of needle fear and/or phobia and fainting in children and adults. Design/Methods: A systematic review identified relevant randomized and quasi-randomized controlled trials of children, adults, or both with high levels of needle fear, including phobia (if not available, then populations with other specific phobias were included). Critically important outcomes were self-reported fear specific to the feared situation and stimulus (psychological interventions) or fainting (applied muscle tension). Data were pooled using standardized mean difference (SMD) or relative risk with 95% confidence intervals. Results: The systematic review included 11 trials. In vivo exposure-based therapy for children 7 years and above showed benefit on specific fear (n=234; SMD: −1.71 [95% CI: −2.72, −0.7]). In vivo exposure-based therapy with adults reduced fear of needles posttreatment (n=20; SMD: −1.09 [−2.04, −0.14]) but not at 1-year follow-up (n=20; SMD: −0.28 [−1.16, 0.6]). Compared with single session, a benefit was observed for multiple sessions of exposure-based therapy posttreatment (n=93; SMD: −0.66 [−1.08, −0.24]) but not after 1 year (n=83; SMD: −0.37 [−0.87, 0.13]). Non in vivo e.g., imaginal exposure-based therapy in children reduced specific fear posttreatment (n=41; SMD: −0.88 [−1.7, −0.05]) and at 3 months (n=24; SMD: −0.89 [−1.73, −0.04]). Non in vivo exposure-based therapy for adults showed benefit on specific fear (n=68; SMD: −0.62 [−1.11, −0.14]) but not procedural fear (n=17; SMD: 0.18 [−0.87, 1.23]). Applied tension showed benefit on fainting posttreatment (n=20; SMD: −1.16 [−2.12, −0.19]) and after 1 year (n=20; SMD: −0.97 [−1.91, −0.03]) compared with exposure alone. Conclusions: Exposure-based psychological interventions and applied muscle tension show

  14. Predictors of High Level of Hostility among Homeless Men on Parole

    PubMed Central

    Nyamathi, Adeline; Salem, Benissa; Farabee, David; Hall, Elizabeth; Zhang, Sheldon; Khalilifard, Farinaz; Faucette, Mark; Leake, Barbara

    2014-01-01

    High levels of hostility present a formidable challenge among homeless ex-offenders. This cross-sectional study assessed correlates of high levels of hostility using baseline data collected on recently-released male parolees (N=472; age 18-60) participating in a randomized trial focused on prevention of illicit drug use and recidivism. Predictors of high levels of hostility included greater depressive symptomatology, lower self-esteem, having a mother who was treated for alcohol/drugs, belonging to a gang, more tangible support, having used methamphetamine and having a history of cognitive difficulties. These findings highlight the need to understand predictors of hostility among recently released homeless men and how these predictors may relate to recidivism. Research implications are discussed as these findings will shape future nurse-led harm reduction and community-based interventions. PMID:25083121

  15. Measurement Error Correction Formula for Cluster-Level Group Differences in Cluster Randomized and Observational Studies

    ERIC Educational Resources Information Center

    Cho, Sun-Joo; Preacher, Kristopher J.

    2016-01-01

    Multilevel modeling (MLM) is frequently used to detect cluster-level group differences in cluster randomized trial and observational studies. Group differences on the outcomes (posttest scores) are detected by controlling for the covariate (pretest scores) as a proxy variable for unobserved factors that predict future attributes. The pretest and…

  16. High-order time-marching reinitialization for regional level-set functions

    NASA Astrophysics Data System (ADS)

    Pan, Shucheng; Lyu, Xiuxiu; Hu, Xiangyu Y.; Adams, Nikolaus A.

    2018-02-01

    In this work, the time-marching reinitialization method is extended to compute the unsigned distance function in multi-region systems involving arbitrary number of regions. High order and interface preservation are achieved by applying a simple mapping that transforms the regional level-set function to the level-set function and a high-order two-step reinitialization method which is a combination of the closest point finding procedure and the HJ-WENO scheme. The convergence failure of the closest point finding procedure in three dimensions is addressed by employing a proposed multiple junction treatment and a directional optimization algorithm. Simple test cases show that our method exhibits 4th-order accuracy for reinitializing the regional level-set functions and strictly satisfies the interface-preserving property. The reinitialization results for more complex cases with randomly generated diagrams show the capability our method for arbitrary number of regions N, with a computational effort independent of N. The proposed method has been applied to dynamic interfaces with different types of flows, and the results demonstrate high accuracy and robustness.

  17. Health Promotion and Preventive Contents Performed During Reproduction System Learning; Observation in Senior High School

    NASA Astrophysics Data System (ADS)

    Yuniarti, E.; Fadilah, M.; Darussyamsu, R.; Nurhayati, N.

    2018-04-01

    The higher numbers of cases around sexual behavioral deviance on adolescence are significantly related to their knowledge level about the health of the reproduction system. Thus, teenagers, especially school-aged, have to receive the complete information which emphasizes on recognize promotion and prevention knowledge. This article aims to describe information about health promotion and prevention, which delivered by the teacher in Senior High School learning process on topic reproduction system. The data gained through focused observation using observation sheet and camera recorder. Further, data analyzed descriptively. The result show promotion and preventive approach have been inadequately presented. There are two reasons. Firstly, the promotion and preventive value are not technically requested in the final assessment. The second, the explanation tend to refer to consequences existed in the term of the social and religious norm rather than a scientific basis. It can be concluded suggestion to promote health reproduction and prevent the risk of health reproduction need to be implemented more practice with a scientific explanation which is included in a specific program for adolescence reproductive health improvement.

  18. Low voltage to high voltage level shifter and related methods

    NASA Technical Reports Server (NTRS)

    Mentze, Erik J. (Inventor); Buck, Kevin M. (Inventor); Hess, Herbert L. (Inventor); Cox, David F. (Inventor)

    2006-01-01

    A shifter circuit comprises a high and low voltage buffer stages and an output buffer stage. The high voltage buffer stage comprises multiple transistors arranged in a transistor stack having a plurality of intermediate nodes connecting individual transistors along the stack. The transistor stack is connected between a voltage level being shifted to and an input voltage. An inverter of this stage comprises multiple inputs and an output. Inverter inputs are connected to a respective intermediate node of the transistor stack. The low voltage buffer stage has an input connected to the input voltage and an output, and is operably connected to the high voltage buffer stage. The low voltage buffer stage is connected between a voltage level being shifted away from and a lower voltage. The output buffer stage is driven by the outputs of the high voltage buffer stage inverter and the low voltage buffer stage.

  19. 3D analysis of high ozone production rates observed during the ESCOMPTE campaign

    NASA Astrophysics Data System (ADS)

    Coll, Isabelle; Pinceloup, Stéphanie; Perros, Pascal E.; Laverdet, Gérard; Le Bras, Georges

    2005-03-01

    The development of environmental policies to reduce the ozone levels around large agglomerations requires a good understanding of the development of ozone episodes. In particular, it is necessary to know the location and photochemical activity of the plume where ozone is formed. Measurement campaigns make it possible not only to characterize the concentration fields of ozone and its precursors but also to identify the zones of strong ozone production, by means of specific measurements and kinetic calculations. The combination of the observation-based data with numerical simulations allows to better characterize photochemical pollution. This paper presents a study carried out within the ESCOMPTE program and based on the determination of ozone production rates by experimental and numerical methods: ground measurements of peroxy radicals, NO x at a rural site, airborne measurements of NO X and O 3, Eulerian modeling. The reported case is of particular interest since it corresponds to an episode with very different photochemical situations. The diurnal variations of the peroxy radical concentration are analyzed in relation to those of ozone and its precursors. Ozone production rates— P(O 3)-are studied over one particular day. The results show particularly high concentrations of RO 2+HO 2 at ground level (up to 200 pptv) under the influence of the urban and industrial plume, but also highlight very high production rates of ozone (60 to 80 ppbv h -1) a few tens of kilometers from the sources. The results show satisfactory agreement between the various approaches. Modeling provides a four-dimensional (4D) description of the plumes, in particular the relation between the ozone precursor concentrations and P(O 3) on the ground.

  20. The Estuary Guide. Level 3: High School. Draft.

    ERIC Educational Resources Information Center

    Alexander, Glen; And Others

    Estuaries are marine systems that serve as nurseries for animals, links in the migratory pathways, and habitat for a complex community of organisms. This curriculum guide intended for use at the high school level seeks to teach what estuaries are; provide opportunities to practice decision-making that affects estuaries; and encourage students to…

  1. Observing phthalate leaching from plasticized polymer films at the molecular level.

    PubMed

    Zhang, Xiaoxian; Chen, Zhan

    2014-05-06

    Phthalates, the most widely used plasticizers in poly(vinyl chloride) (PVC), have been extensively studied. In this paper, a highly sensitive, easy, and effective method was developed to examine short-term phthalate leaching from PVC/phthalate films at the molecular level using sum frequency generation vibrational spectroscopy (SFG). Combining SFG and Fourier transform infrared spectroscopy (FTIR), surface and bulk molecular structures of PVC/phthalate films were also comprehensively evaluated during the phthalate leaching process under various environments. The leaching processes of two phthalates, diethyl phthalate (DEP) and dibutyl phthalate (DBP), from the PVC/phthalate films with various weight ratios were studied. Oxygen plasma was applied to treat the PVC/phthalate film surfaces to verify its efficacy on preventing/reducing phthalate leaching from PVC. Our results show that DBP is more stable than DEP in PVC/phthalate films. Even so, DBP molecules were still found to very slowly leach to the environment from PVC at 30 °C, at a rate much slower than DEP. Also, the bulk DBP content substantially influences the DBP leaching. Higher DBP bulk concentration yields less stable DBP molecules in the PVC matrix, allowing molecules to leach from the polymer film more easily. Additionally, DBP leaching is very sensitive to temperature changes; higher temperature can strongly enhance the leaching process. For most cases, the oxygen plasma treatment can effectively prevent phthalate leaching from PVC films (e.g., for samples with low bulk concentrations of DBP-5 and 30 wt %). It is also capable of reducing phthalate leaching from high DBP bulk concentration PVC samples (e.g., 70 wt % DBP in PVC/DBP mixture). This research develops a highly sensitive method to detect chemicals at the molecular level as well as provides surface and bulk molecular structural changes. The method developed here is general and can be applied to detect small amounts of chemical

  2. Calculation of intensity of high energy muon groups observed deep underground

    NASA Technical Reports Server (NTRS)

    Vavilov, Y. N.; Dedenko, L. G.

    1985-01-01

    The intensity of narrow muon groups observed in Kolar Gold Field (KGF) at the depth of 3375 m.w.e. was calculated in terms of quark-gluon strings model for high energy hadron - air nuclei interactions by the method of direct modeling of nuclear cascade in the air and muon propagation in the ground for normal primary cosmic ray composition. The calculated intensity has been found to be approx. 10 to the 4 times less than one observed experimentally.

  3. Improve observation-based ground-level ozone spatial distribution by compositing satellite and surface observations: A simulation experiment

    NASA Astrophysics Data System (ADS)

    Zhang, Yuzhong; Wang, Yuhang; Crawford, James; Cheng, Ye; Li, Jianfeng

    2018-05-01

    Obtaining the full spatial coverage of daily surface ozone fields is challenging because of the sparsity of the surface monitoring network and the difficulty in direct satellite retrievals of surface ozone. We propose an indirect satellite retrieval framework to utilize the information from satellite-measured column densities of tropospheric NO2 and CH2O, which are sensitive to the lower troposphere, to derive surface ozone fields. The method is applicable to upcoming geostationary satellites with high-quality NO2 and CH2O measurements. To prove the concept, we conduct a simulation experiment using a 3-D chemical transport model for July 2011 over the eastern US. The results show that a second order regression using both NO2 and CH2O column densities can be an effective predictor for daily maximum 8-h average ozone. Furthermore, this indirect retrieval approach is shown to be complementary to spatial interpolation of surface observations, especially in regions where the surface sites are sparse. Combining column observations of NO2 and CH2O with surface site measurements leads to an improved representation of surface ozone over simple kriging, increasing the R2 value from 0.53 to 0.64 at a surface site distance of 252 km. The improvements are even more significant with larger surface site distances. The simulation experiment suggests that the indirect satellite retrieval technique can potentially be a useful tool to derive the full spatial coverage of daily surface ozone fields if satellite observation uncertainty is moderate.

  4. High-level production of human interleukin-10 fusions in tobacco cell suspension cultures

    PubMed Central

    Kaldis, Angelo; Ahmad, Adil; Reid, Alexandra; McGarvey, Brian; Brandle, Jim; Ma, Shengwu; Jevnikar, Anthony; Kohalmi, Susanne E; Menassa, Rima

    2013-01-01

    The production of pharmaceutical proteins in plants has made much progress in recent years with the development of transient expression systems, transplastomic technology and humanizing glycosylation patterns in plants. However, the first therapeutic proteins approved for administration to humans and animals were made in plant cell suspensions for reasons of containment, rapid scale-up and lack of toxic contaminants. In this study, we have investigated the production of human interleukin-10 (IL-10) in tobacco BY-2 cell suspension and evaluated the effect of an elastin-like polypeptide tag (ELP) and a green fluorescent protein (GFP) tag on IL-10 accumulation. We report the highest accumulation levels of hIL-10 obtained with any stable plant expression system using the ELP fusion strategy. Although IL-10-ELP has cytokine activity, its activity is reduced compared to unfused IL-10, likely caused by interference of ELP with folding of IL-10. Green fluorescent protein has no effect on IL-10 accumulation, but examining the trafficking of IL-10-GFP over the cell culture cycle revealed fluorescence in the vacuole during the stationary phase of the culture growth cycle. Analysis of isolated vacuoles indicated that GFP alone is found in vacuoles, while the full-size fusion remains in the whole-cell extract. This indicates that GFP is cleaved off prior to its trafficking to the vacuole. On the other hand, IL-10-GFP-ELP remains mostly in the ER and accumulates to high levels. Protein bodies were observed at the end of the culture cycle and are thought to arise as a consequence of high levels of accumulation in the ER. PMID:23297698

  5. Construction, geologic, and water-level data for observation wells near Brentwood, Williamson County, Tennessee

    USGS Publications Warehouse

    Hanchar, Dorothea Withington

    1989-01-01

    Thirty-four observation wells were installed at 17 sites in the area of a hazardous-waste disposal site near Brentwood, in Williamson County, Tennessee. These wells were installed to supplement data collected from domestic wells in the area, to help define the geology of the study area and to determine the water levels. Both lithologic and geophysical logs were obtained for each well drilled to help define the formations encountered. Four limestone units, corresponding to the Bigby-Cannon limestone, the Hermitage Formation, the Carters Limestone (including the T-3 bentonite), and the Lebanon Limestone, were described from well cuttings and borehole geophysical logs. Water levels have been collected at both the shallow and deep wells at each site. (USGS)

  6. Ocean impact on decadal Atlantic climate variability revealed by sea-level observations.

    PubMed

    McCarthy, Gerard D; Haigh, Ivan D; Hirschi, Joël J-M; Grist, Jeremy P; Smeed, David A

    2015-05-28

    Decadal variability is a notable feature of the Atlantic Ocean and the climate of the regions it influences. Prominently, this is manifested in the Atlantic Multidecadal Oscillation (AMO) in sea surface temperatures. Positive (negative) phases of the AMO coincide with warmer (colder) North Atlantic sea surface temperatures. The AMO is linked with decadal climate fluctuations, such as Indian and Sahel rainfall, European summer precipitation, Atlantic hurricanes and variations in global temperatures. It is widely believed that ocean circulation drives the phase changes of the AMO by controlling ocean heat content. However, there are no direct observations of ocean circulation of sufficient length to support this, leading to questions about whether the AMO is controlled from another source. Here we provide observational evidence of the widely hypothesized link between ocean circulation and the AMO. We take a new approach, using sea level along the east coast of the United States to estimate ocean circulation on decadal timescales. We show that ocean circulation responds to the first mode of Atlantic atmospheric forcing, the North Atlantic Oscillation, through circulation changes between the subtropical and subpolar gyres--the intergyre region. These circulation changes affect the decadal evolution of North Atlantic heat content and, consequently, the phases of the AMO. The Atlantic overturning circulation is declining and the AMO is moving to a negative phase. This may offer a brief respite from the persistent rise of global temperatures, but in the coupled system we describe, there are compensating effects. In this case, the negative AMO is associated with a continued acceleration of sea-level rise along the northeast coast of the United States.

  7. High Levels of Serum Ubiquitin and Proteasome in a Case of HLA-B27 Uveitis.

    PubMed

    Rossi, Settimio; Gesualdo, Carlo; Maisto, Rosa; Trotta, Maria Consiglia; Di Carluccio, Nadia; Brigida, Annalisa; Di Iorio, Valentina; Testa, Francesco; Simonelli, Francesca; D'Amico, Michele; Di Filippo, Clara

    2017-02-26

    In this paper, the authors describe a case of high serum levels of ubiquitin and proteasome in a woman under an acute attack of autoimmune uveitis. The woman was 52 years old, diagnosed as positive for the Human leukocyte antigen-B27 gene, and came to our observation in January 2013 claiming a severe uveitis attack that involved the right eye. During the acute attack of uveitis, this woman had normal serum biochemical parameters but higher levels of serum ubiquitin and proteasome 20S subunit, with respect to a healthy volunteer matched for age and sex. These levels correlated well with the clinical score attributed to uveitis. After the patient was admitted to therapy, she received oral prednisone in a de-escalation protocol (doses from 50 to 5 mg/day) for four weeks. Following this therapy, she had an expected reduction of clinical signs and score for uveitis, but concomitantly she had a reduction of the serum levels of ubiquitin, poliubiquitinated proteins (MAb-FK1) and proteasome 20S activity. Therefore, a role for ubiquitin and proteasome in the development of human autoimmune uveitis has been hypothesized.

  8. Effects of Observing Eye Contact on Gaze Following in High-Functioning Autism

    ERIC Educational Resources Information Center

    Böckler, Anne; Timmermans, Bert; Sebanz, Natalie; Vogeley, Kai; Schilbach, Leonhard

    2014-01-01

    Observing eye contact between others enhances the tendency to subsequently follow their gaze and has been suggested to function as a social signal that adds meaning to an upcoming action or event. The present study investigated effects of observed eye contact in high-functioning autism (HFA). Two faces on a screen either looked at or away from…

  9. High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1.

    PubMed

    Maya Miles, Douglas; Peñate, Xenia; Sanmartín Olmo, Trinidad; Jourquin, Frederic; Muñoz Centeno, Maria Cruz; Mendoza, Manuel; Simon, Marie-Noelle; Chavez, Sebastian; Geli, Vincent

    2018-03-27

    Whole-genome duplications (WGDs) have played a central role in the evolution of genomes and constitute an important source of genome instability in cancer. Here, we show in Saccharomyces cerevisiae that abnormal accumulations of histones are sufficient to induce WGDs. Our results link these WGDs to a reduced incorporation of the histone variant H2A.Z to chromatin. Moreover, we show that high levels of histones promote Swe1 WEE1 stabilisation thereby triggering the phosphorylation and inhibition of Cdc28 CDK1 through a mechanism different of the canonical DNA damage response. Our results link high levels of histones to a specific type of genome instability that is quite frequently observed in cancer and uncovers a new mechanism that might be able to respond to high levels of histones. © 2018, Maya Miles et al.

  10. Low prevalence of type 2 diabetes mellitus among patients with high levels of high-density lipoprotein cholesterol.

    PubMed

    Juren, Andrew J; Sarwal, Gautamn; Al-Sarraf, Ahmad; Vrablik, Michal; Chan, Darren; Humphries, Karin H; Frohlich, Jiri J

    2013-01-01

    Diabetes mellitus and low levels of high-density lipoprotein cholesterol (HDL-C) are among several known risk factors for coronary artery disease. Recent research has shown potential mechanistic links between these two diseases. The aim of our study was to characterize, by examining particular coronary artery disease risk factors, patients with extremely high and low levels of HDL-C who were referred to a prevention clinic. We compared the phenotypes of 113 patients with HDL-C levels greater than the 90th percentile with 212 patients with levels less than the 10th percentile by using a retrospective chart review. The cohort with high HDL-C had a remarkable difference in the incidence of type 2 diabetes (1.8% vs 21.7%). The high HDL-C cohort also had a greater age (52.1 years vs 46.7 years), more light or moderate alcohol consumption (70.8% vs 49.4%), more healthy diet (30.1% vs 22.4%), more light or moderate exercise (90.8% vs 52.2%), and a lower body mass index (25.2 kg/m² vs 28.1 kg/m²). Compared with the low HDL-C group--and also the general population--the high HDL-C cohort had a remarkably low prevalence of diabetes mellitus. Copyright © 2013 National Lipid Association. Published by Elsevier Inc. All rights reserved.

  11. Spatial Heterodyne Observation of Water (SHOW) from a high altitude aircraft

    NASA Astrophysics Data System (ADS)

    Bourassa, A. E.; Langille, J.; Solheim, B.; Degenstein, D. A.; Letros, D.; Lloyd, N. D.; Loewen, P.

    2017-12-01

    The Spatial Heterodyne Observations of Water instrument (SHOW) is limb-sounding satellite prototype that is being developed in collaboration between the University of Saskatchewan, York University, the Canadian Space Agency and ABB. The SHOW instrument combines a field-widened SHS with an imaging system to observe limb-scattered sunlight in a vibrational band of water (1363 nm - 1366 nm). Currently, the instrument has been optimized for deployment on NASA's ER-2 aircraft. Flying at an altitude of 70, 000 ft the ER-2 configuration and SHOW viewing geometry provides high spatial resolution (< 500 m) limb-measurements of water vapor in the Upper troposphere and lower stratosphere region. During an observation campaign from July 15 - July 22, the SHOW instrument performed 10 hours of observations from the ER-2. This paper describes the SHOW measurement technique and presents the preliminary analysis and results from these flights. These observations are used to validate the SHOW measurement technique and demonstrate the sampling capabilities of the instrument.

  12. Analysis of clinical observation on acute psychiatric wards.

    PubMed

    Najim, Hellme; Saleem, Khalid; Al Shirbiny, Basil; Ezeasor, Nebo

    2013-09-01

    Clinical observation is very important to manage risk of people who are acutely ill on psychiatric wards. It is always an area of dispute between different specialities and disciplines in serious untoward incidents (SUI). Three levels of observations have been applied on acute psychiatric words. Assessing practice is important to help to identify any area needs improving. A questionnaire was developed by HN to collect demographics. Medical notes on Westley and Grangewater wards were reviewed. Excel Microsoft Office World Computer Programme was used to analyse the results. 57% were men. 62% were above 41 years of age. Majority were suffering from schizophrenia and schizoaffective disorders 61%. 64.28% were admitted as formal patients. 31.42% were on level I observation.62.53 were informal. 54.76% were risk to themselves, 28.57% risk to others. 82.3% were on level II observation, 31.42% formal and 68.50% informal. 21.32% were on level III observation. 66.66% were formal and 66.66% had an incident before this level. This study have shown that patients are assessed properly before they go on any level of care. Some patients need to go on level III as they pose a risk mainly to other people. Regular reviews of patients, especially on high level of observation should be done more promptly, as being on observation is not a comfortable experience to go through and applying the least restrictive practice should always be sought and adopted.

  13. A high-speed DAQ framework for future high-level trigger and event building clusters

    NASA Astrophysics Data System (ADS)

    Caselle, M.; Ardila Perez, L. E.; Balzer, M.; Dritschler, T.; Kopmann, A.; Mohr, H.; Rota, L.; Vogelgesang, M.; Weber, M.

    2017-03-01

    Modern data acquisition and trigger systems require a throughput of several GB/s and latencies of the order of microseconds. To satisfy such requirements, a heterogeneous readout system based on FPGA readout cards and GPU-based computing nodes coupled by InfiniBand has been developed. The incoming data from the back-end electronics is delivered directly into the internal memory of GPUs through a dedicated peer-to-peer PCIe communication. High performance DMA engines have been developed for direct communication between FPGAs and GPUs using "DirectGMA (AMD)" and "GPUDirect (NVIDIA)" technologies. The proposed infrastructure is a candidate for future generations of event building clusters, high-level trigger filter farms and low-level trigger system. In this paper the heterogeneous FPGA-GPU architecture will be presented and its performance be discussed.

  14. Low zinc serum levels and high blood lead levels among school-age children in coastal area

    NASA Astrophysics Data System (ADS)

    Pramono, Adriyan; Panunggal, Binar; Rahfiludin, M. Zen; Swastawati, Fronthea

    2017-02-01

    The coverage of environmental lead toxicant was quiet wide. Lead exposure recently has been expected to be associated with zinc deficiency and blood indices disturbance. Emphasizing on children, which could absorb more than 50 % of lead that enters the body. Lead became the issue on the coastal area due to it has polluted the environment and waters as the source of fisheries products. This was a cross sectional study to determined nutritional status, blood lead levels, zinc serum levels, blood indices levels, fish intake among school children in coastal region of Semarang. This study was carried out on the school children aged between 8 and 12 years old in coastal region of Semarang. Nutritional status was figured out using anthropometry measurement. Blood lead and zinc serum levels were analyzed using the Atomic Absorbent Spectrophotometry (AAS) at a wavelength of 213.9 nm for zinc serum and 283.3 nm for blood lead. Blood indices was measured using auto blood hematology analyzer. Fish intake was assessed using 3-non consecutive days 24-hours food recall. The children had high lead levels (median 34.86 μg/dl, range 11.46 - 58.86 μg/dl) compared to WHO cut off. Zinc serum levels was low (median 18.10 μg/dl, range 10.25 - 41.39 μg/dl) compared to the Joint WHO/UNICEF/IAEA/IZiNCG cut off. Approximately 26.4% of children were anemic. This study concluded that all school children had high blood lead levels, low zinc serum, and presented microcytic hypochromic anemia. This phenomenon should be considered as public health concern.

  15. Crystal accumulation in the Hanford Waste Treatment Plant high level waste melter: Summary of 2017 experiments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fox, K.; Fowley, M.

    A full-scale, transparent mock-up of the Hanford Tank Waste Treatment and Immobilization Project High Level Waste glass melter riser and pour spout has been constructed to allow for testing with visual feedback of particle settling, accumulation, and resuspension when operating with a controlled fraction of crystals in the glass melt. Room temperature operation with silicone oil and magnetite particles simulating molten glass and spinel crystals, respectively, allows for direct observation of flow patterns and settling patterns. The fluid and particle mixture is recycled within the system for each test.

  16. High-resolution observations of the globular cluster NGC 7099

    NASA Astrophysics Data System (ADS)

    Sams, Bruce Jones, III

    The globular cluster NGC 7099 is a prototypical collapsed core cluster. Through a series of instrumental, observational, and theoretical observations, I have resolved its core structure using a ground based telescope. The core has a radius of 2.15 arcsec when imaged with a V band spatial resolution of 0.35 arcsec. Initial attempts at speckle imaging produced images of inadequate signal to noise and resolution. To explain these results, a new, fully general signal-to-noise model has been developed. It properly accounts for all sources of noise in a speckle observation, including aliasing of high spatial frequencies by inadequate sampling of the image plane. The model, called Full Speckle Noise (FSN), can be used to predict the outcome of any speckle imaging experiment. A new high resolution imaging technique called ACT (Atmospheric Correlation with a Template) was developed to create sharper astronomical images. ACT compensates for image motion due to atmospheric turbulence. ACT is similar to the Shift and Add algorithm, but uses apriori spatial knowledge about the image to further constrain the shifts. In this instance, the final images of NGC 7099 have resolutions of 0.35 arcsec from data taken in 1 arcsec seeing. The PAPA (Precision Analog Photon Address) camera was used to record data. It is subject to errors when imaging cluster cores in a large field of view. The origin of these errors is explained, and several ways to avoid them proposed. New software was created for the PAPA camera to properly take flat field images taken in a large field of view. Absolute photometry measurements of NGC 7099 made with the PAPA camera are accurate to 0.1 magnitude. Luminosity sampling errors dominate surface brightness profiles of the central few arcsec in a collapsed core cluster. These errors set limits on the ultimate spatial accuracy of surface brightness profiles. high resolution; even to a perfectly functioning Hubble

  17. Pseudophakodonesis and corneal endothelial contact: direct observations by high-speed cinematography.

    PubMed

    Jacobs, P M; Cheng, H; Price, N C

    1983-10-01

    High-speed cinematography was used to observe the movement of Federov type I lens implants within the anterior chamber. Our measurements suggest that in most patients contact between the lens implant and corneal endothelium does not occur.

  18. Observed to expected or logistic regression to identify hospitals with high or low 30-day mortality?

    PubMed Central

    Helgeland, Jon; Clench-Aas, Jocelyne; Laake, Petter; Veierød, Marit B.

    2018-01-01

    Introduction A common quality indicator for monitoring and comparing hospitals is based on death within 30 days of admission. An important use is to determine whether a hospital has higher or lower mortality than other hospitals. Thus, the ability to identify such outliers correctly is essential. Two approaches for detection are: 1) calculating the ratio of observed to expected number of deaths (OE) per hospital and 2) including all hospitals in a logistic regression (LR) comparing each hospital to a form of average over all hospitals. The aim of this study was to compare OE and LR with respect to correctly identifying 30-day mortality outliers. Modifications of the methods, i.e., variance corrected approach of OE (OE-Faris), bias corrected LR (LR-Firth), and trimmed mean variants of LR and LR-Firth were also studied. Materials and methods To study the properties of OE and LR and their variants, we performed a simulation study by generating patient data from hospitals with known outlier status (low mortality, high mortality, non-outlier). Data from simulated scenarios with varying number of hospitals, hospital volume, and mortality outlier status, were analysed by the different methods and compared by level of significance (ability to falsely claim an outlier) and power (ability to reveal an outlier). Moreover, administrative data for patients with acute myocardial infarction (AMI), stroke, and hip fracture from Norwegian hospitals for 2012–2014 were analysed. Results None of the methods achieved the nominal (test) level of significance for both low and high mortality outliers. For low mortality outliers, the levels of significance were increased four- to fivefold for OE and OE-Faris. For high mortality outliers, OE and OE-Faris, LR 25% trimmed and LR-Firth 10% and 25% trimmed maintained approximately the nominal level. The methods agreed with respect to outlier status for 94.1% of the AMI hospitals, 98.0% of the stroke, and 97.8% of the hip fracture hospitals

  19. Aerosol and Cloud Interaction Observed From High Spectral Resolution Lidar Data

    NASA Technical Reports Server (NTRS)

    Su, Wenying; Schuster, Gregory L.; Loeb, Norman G.; Rogers, Raymond R.; Ferrare, Richard A.; Hostetler, Chris A.; Hair, Johnathan W.; Obland, Michael D.

    2008-01-01

    Recent studies utilizing satellite retrievals have shown a strong correlation between aerosol optical depth (AOD) and cloud cover. However, these retrievals from passive sensors are subject to many limitations, including cloud adjacency (or 3D) effects, possible cloud contamination, uncertainty in the AOD retrieval. Some of these limitations do not exist in High Spectral Resolution Lidar (HSRL) observations; for instance, HSRL observations are not a ected by cloud adjacency effects, are less prone to cloud contamination, and offer accurate aerosol property measurements (backscatter coefficient, extinction coefficient, lidar ratio, backscatter Angstrom exponent,and aerosol optical depth) at a neospatial resolution (less than 100 m) in the vicinity of clouds. Hence, the HSRL provides an important dataset for studying aerosol and cloud interaction. In this study, we statistically analyze aircraft-based HSRL profiles according to their distance from the nearest cloud, assuring that all profile comparisons are subject to the same large-scale meteorological conditions. Our results indicate that AODs from HSRL are about 17% higher in the proximity of clouds (approximately 100 m) than far away from clouds (4.5 km), which is much smaller than the reported cloud 3D effect on AOD retrievals. The backscatter and extinction coefficients also systematically increase in the vicinity of clouds, which can be explained by aerosol swelling in the high relative humidity (RH) environment and/or aerosol growth through in cloud processing (albeit not conclusively). On the other hand, we do not observe a systematic trend in lidar ratio; we hypothesize that this is caused by the opposite effects of aerosol swelling and aerosol in-cloud processing on the lidar ratio. Finally, the observed backscatter Angstrom exponent (BAE) does not show a consistent trend because of the complicated relationship between BAE and RH. We demonstrate that BAE should not be used as a surrogate for Angstrom

  20. Postoperative Changes in Presepsin Level and Values Predictive of Surgical Site Infection After Spinal Surgery: A Single-Center, Prospective Observational Study.

    PubMed

    Koakutsu, Tomoaki; Sato, Tetsuya; Aizawa, Toshimi; Itoi, Eiji; Kushimoto, Shigeki

    2018-04-15

    Single-institutional, prospective observational study. To elucidate the perioperative kinetics of presepsin (PSEP) in patients undergoing spinal surgery, and to evaluate the possibility of PSEP in the early diagnosis of surgical site infection (SSI). Early diagnosis of SSI after spinal surgery is important. Although several biomarkers have been used as early indicators of SSI, the specificity of these markers in SSI diagnosis was not high. PSEP was found as a novel diagnostic marker for bacterial sepsis in 2004. However, its kinetics after spinal surgery and its usefulness in early diagnosis of SSI have never been evaluated. A total of 118 patients who underwent elective spinal surgery were enrolled. PSEP was measured before, immediately after, 1 day after, and 1 week after surgery. In patients without postoperative infection, perioperative kinetics of PSEP were analyzed. PSEP levels in patients with postoperative infection were also recorded separately, and their utility in SSI diagnosis was evaluated. In the 115 patients without postoperative infection, the median PSEP value was 126, 171, 194, and 147 pg/mL before, immediately after, 1 day after, and 1 week after surgery, respectively. Compared with the preoperative value, PSEP was significantly higher immediately after surgery and the next day, and return to the preoperative level 1 week after surgery. The estimated reference value for 95 percentile in patients without postoperative infection was 297 pg/mL 1 week after surgery. In three patients with postoperative infection, higher levels (>300 pg/mL) were observed 1 week after surgery. In patients after spinal surgery without infectious complications, blood levels of PSEP may immediately increase and return to preoperative levels 1 week after surgery. The PSEP value of 300 pg/mL 1 week after surgery might be used as a novel indicator for suspected SSI. 4.

  1. High-level manpower movement and Japan's foreign aid.

    PubMed

    Furuya, K

    1992-01-01

    "Japan's technical assistance programs to Asian countries are summarized. Movements of high-level manpower accompanying direct foreign investments by private enterprise are also reviewed. Proposals for increased human resources development include education and training of foreigners in Japan as well as the training of Japanese aid experts and the development of networks for information exchange." excerpt

  2. High-level neutron coincidence counter maintenance manual

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Swansen, J.; Collinsworth, P.

    1983-05-01

    High-level neutron coincidence counter operational (field) calibration and usage is well known. This manual makes explicit basic (shop) check-out, calibration, and testing of new units and is a guide for repair of failed in-service units. Operational criteria for the major electronic functions are detailed, as are adjustments and calibration procedures, and recurrent mechanical/electromechanical problems are addressed. Some system tests are included for quality assurance. Data on nonstandard large-scale integrated (circuit) components and a schematic set are also included.

  3. Reduction in postoperative high-density lipoprotein cholesterol levels in children undergoing the Fontan operation.

    PubMed

    Zyblewski, Sinai C; Argraves, W Scott; Graham, Eric M; Slate, Elizabeth H; Atz, Andrew M; Bradley, Scott M; McQuinn, Tim C; Wilkerson, Brent A; Wing, Shane B; Argraves, Kelley M

    2012-10-01

    Despite the emerging relevance of high-density lipoprotein (HDL) in the inflammatory cascade and vascular barrier integrity, HDL levels in children undergoing cardiac surgery are unexplored. As a measure of HDL levels, the HDL-cholesterol (HDL-C) in single-ventricle patients was quantified before and after the Fontan operation, and it was determined whether relationships existed between the duration and the type of postoperative pleural effusions. The study prospectively enrolled 12 children undergoing the Fontan operation. Plasma HDL-C levels were measured before and after cardiopulmonary bypass. The outcome variables of interest were the duration and type of chest tube drainage (chylous vs. nonchylous). The Kendall rank correlation coefficient and the Wilcoxon rank sum test were used. There were 11 complete observations. The median preoperative HDL-C level for all the subjects was 30 mg/dl (range, 24-53 mg/dl), and the median postcardiopulmonary bypass level was 21 mg/dl (range, 14-46 mg/dl) (p = 0.004). There was a tendency toward a moderate inverse correlation (-0.42) between the postcardiopulmonary bypass HDL-C level and the duration of chest tube drainage, but the result was not statistically significant (p = 0.07). In the chylous effusion group, the median postcardiopulmonary bypass HDL-C tended to be lower (16 vs. 23 mg/dl; p = 0.09). After the Fontan operation, the plasma HDL-C levels in children are significantly reduced. It is reasonable to conclude that the reduction in HDL-C reflects reduced plasma levels of HDL particles, which may have pertinent implications in postoperative pleural effusions given the antiinflammatory and endothelial barrier functions of HDL.

  4. Observing Flow in Young Children's Music Learning.

    ERIC Educational Resources Information Center

    Custodero, Lori A.

    1998-01-01

    Explores a study that quantifies preschool children's music learning preferences in teacher-intitiated environments by observing the children on video to determine their flow experiences where the challenge level and skill level are both high. Stresses that using flow to measure music experiences provides a means for teachers to evaluate student…

  5. Changes in Heart Rate Variability Recorded in Natural Situation with T-Shirt Integrated Sensors and Level of Observed Behavioral Excitation: A Pilot Study of Patients with Intellectual Disabilities and Psychiatric Disorders.

    PubMed

    Palix, Julie; Akselrod, Michel; Cungi, Charly; Giuliani, Fabienne; Favrod, Jérôme

    2017-01-01

    The present study investigates the possibilities of using heart rate variability (HRV) parameters as physiological markers that precede increase in observed behavioral excitation of intellectually disabled individuals. The ability to recognize or predict such patterns, especially in patients showing unpredictable reactions and language deficiencies, might be a major step forward in clinical research. Thirteen volunteers with intellectual disabilities, who had suffered of at least one event of overt aggression in the preceding 3 months, participated to the study. The protocol consists in the acquisition of continuous electrocardiogram (ECG) throughout approximately two times of 8 h in natural situation, using a T-shirt integrated with sensors. Simultaneously, an observer evaluates the patient's level of overt excitation from calm (level 1) to extremely tense (level 5) and send online via Bluetooth these triggers into the ECG signals. The HRV indexes were then estimated offline on the basis of the inter-beat intervals recorded by the ECG, independently for the 30 min preceding each behavioral tension marking point, averaged, and compared through non-parametric Wilcoxon matched-pairs test. Of these, the RMSSD and LF/HF calculations were used to observe the fluctuations of inhibitory activity and cardiovagal balance through different tension states. Seven individuals have sufficient reliable data for analysis. They have reached at least a level 3 of behavioral excitation (moderately tense) or more (very to extremely tense, level 4 and 5) and have been retained for further analysis. In sum, a total of 197 periods of tension were kept, made up of 46 periods of slight excitation (level 2), 18 of moderate excitation (level 3), 10 of high excitation (level 4), and 5 of extreme agitation (level 5). Variations in the HRV as a function of degree of excitation are observed for RMSSD index only (inhibitory parasympathetic activity). The changes from calm to increasing

  6. A high-resolution open biomass burning emission inventory based on statistical data and MODIS observations in mainland China

    NASA Astrophysics Data System (ADS)

    Xu, Y.; Fan, M.; Huang, Z.; Zheng, J.; Chen, L.

    2017-12-01

    Open biomass burning which has adverse effects on air quality and human health is an important source of gas and particulate matter (PM) in China. Current emission estimations of open biomass burning are generally based on single source (alternative to statistical data and satellite-derived data) and thus contain large uncertainty due to the limitation of data. In this study, to quantify the 2015-based amount of open biomass burning, we established a new estimation method for open biomass burning activity levels by combining the bottom-up statistical data and top-down MODIS observations. And three sub-category sources which used different activity data were considered. For open crop residue burning, the "best estimate" of activity data was obtained by averaging the statistical data from China statistical yearbooks and satellite observations from MODIS burned area product MCD64A1 weighted by their uncertainties. For the forest and grassland fires, their activity levels were represented by the combination of statistical data and MODIS active fire product MCD14ML. Using the fire radiative power (FRP) which is considered as a better indicator of active fire level as the spatial allocation surrogate, coarse gridded emissions were reallocated into 3km ×3km grids to get a high-resolution emission inventory. Our results showed that emissions of CO, NOx, SO2, NH3, VOCs, PM2.5, PM10, BC and OC in mainland China were 6607, 427, 84, 79, 1262, 1198, 1222, 159 and 686 Gg/yr, respectively. Among all provinces of China, Henan, Shandong and Heilongjiang were the top three contributors to the total emissions. In this study, the developed open biomass burning emission inventory with a high-resolution could support air quality modeling and policy-making for pollution control.

  7. Ethical challenges related to elder care. High level decision-makers' experiences.

    PubMed

    Mamhidir, Anna-Greta; Kihlgren, Mona; Sorlie, Venke

    2007-04-10

    Few empirical studies have been found that explore ethical challenges among persons in high public positions that are responsible for elder care. The aim of this paper was to illuminate the meaning of being in ethically difficult situations related to elder care as experienced by high level decision-makers. A phenomenological-hermeneutic method was used to analyse the eighteen interviews conducted with political and civil servant high level decision-makers at the municipality and county council level from two counties in Sweden. The participants worked at a planning and control as well as executive level and had both budget and quality of elder care responsibilities. Both ethical dilemmas and the meaning of being in ethically difficult situations related to elder care were revealed. No differences were seen between the politicians and the civil servants. The ethical dilemmas mostly concerned dealings with extensive care needs and working with a limited budget. The dilemmas were associated with a lack of good care and a lack of agreement concerning care such as vulnerable patients in inappropriate care settings, weaknesses in medical support, dissimilar focuses between the caring systems, justness in the distribution of care and deficient information. Being in ethically difficult situations was challenging. Associated with them were experiences of being exposed, having to be strategic and living with feelings such as aloneness and loneliness, uncertainty, lack of confirmation, the risk of being threatened or becoming a scapegoat and difficult decision avoidance. Our paper provides further insight into the ethical dilemmas and ethical challenges met by high level decision-makers', which is important since the overall responsibility for elder care that is also ethically defensible rests with them. They have power and their decisions affect many stakeholders in elder care. Our results can be used to stimulate discussions between high level decision-makers and health

  8. Ethical challenges related to elder care. High level decision-makers' experiences

    PubMed Central

    Mamhidir, Anna-Greta; Kihlgren, Mona; Sorlie, Venke

    2007-01-01

    Background Few empirical studies have been found that explore ethical challenges among persons in high public positions that are responsible for elder care. The aim of this paper was to illuminate the meaning of being in ethically difficult situations related to elder care as experienced by high level decision-makers. Methods A phenomenological-hermeneutic method was used to analyse the eighteen interviews conducted with political and civil servant high level decision-makers at the municipality and county council level from two counties in Sweden. The participants worked at a planning and control as well as executive level and had both budget and quality of elder care responsibilities. Results Both ethical dilemmas and the meaning of being in ethically difficult situations related to elder care were revealed. No differences were seen between the politicians and the civil servants. The ethical dilemmas mostly concerned dealings with extensive care needs and working with a limited budget. The dilemmas were associated with a lack of good care and a lack of agreement concerning care such as vulnerable patients in inappropriate care settings, weaknesses in medical support, dissimilar focuses between the caring systems, justness in the distribution of care and deficient information. Being in ethically difficult situations was challenging. Associated with them were experiences of being exposed, having to be strategic and living with feelings such as aloneness and loneliness, uncertainty, lack of confirmation, the risk of being threatened or becoming a scapegoat and difficult decision avoidance. Conclusion Our paper provides further insight into the ethical dilemmas and ethical challenges met by high level decision-makers', which is important since the overall responsibility for elder care that is also ethically defensible rests with them. They have power and their decisions affect many stakeholders in elder care. Our results can be used to stimulate discussions between

  9. DESIGN ANALYSIS FOR THE DEFENSE HIGH-LEVEL WASTE DISPOSAL CONTAINER

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    G. Radulesscu; J.S. Tang

    The purpose of ''Design Analysis for the Defense High-Level Waste Disposal Container'' analysis is to technically define the defense high-level waste (DHLW) disposal container/waste package using the Waste Package Department's (WPD) design methods, as documented in ''Waste Package Design Methodology Report'' (CRWMS M&O [Civilian Radioactive Waste Management System Management and Operating Contractor] 2000a). The DHLW disposal container is intended for disposal of commercial high-level waste (HLW) and DHLW (including immobilized plutonium waste forms), placed within disposable canisters. The U.S. Department of Energy (DOE)-managed spent nuclear fuel (SNF) in disposable canisters may also be placed in a DHLW disposal container alongmore » with HLW forms. The objective of this analysis is to demonstrate that the DHLW disposal container/waste package satisfies the project requirements, as embodied in Defense High Level Waste Disposal Container System Description Document (SDD) (CRWMS M&O 1999a), and additional criteria, as identified in Waste Package Design Sensitivity Report (CRWMS M&Q 2000b, Table 4). The analysis briefly describes the analytical methods appropriate for the design of the DHLW disposal contained waste package, and summarizes the results of the calculations that illustrate the analytical methods. However, the analysis is limited to the calculations selected for the DHLW disposal container in support of the Site Recommendation (SR) (CRWMS M&O 2000b, Section 7). The scope of this analysis is restricted to the design of the codisposal waste package of the Savannah River Site (SRS) DHLW glass canisters and the Training, Research, Isotopes General Atomics (TRIGA) SNF loaded in a short 18-in.-outer diameter (OD) DOE standardized SNF canister. This waste package is representative of the waste packages that consist of the DHLW disposal container, the DHLW/HLW glass canisters, and the DOE-managed SNF in disposable canisters. The intended use of this analysis

  10. Genotypic and phenotypic characterization of methicillin-resistant Staphylococcus aureus (MRSA) clones with high-level mupirocin resistance.

    PubMed

    González-Domínguez, María; Seral, Cristina; Potel, Carmen; Sáenz, Yolanda; Álvarez, Maximiliano; Torres, Carmen; Castillo, Francisco Javier

    2016-06-01

    A high proportion of methicillin-resistant Staphylococcus aureus isolates recovered in one year period showed high-level mupirocin-resistance (HLMUPR-MRSA) in our environment (27.2%). HLMUPR-MRSA isolates were mainly collected from skin and soft tissue samples, and diabetes was the main related comorbidity condition. These isolates were more frequently found in vascular surgery. HLMUPR-MRSA was more resistant to aminoglycosides than mupirocin-susceptible MRSA, linked to the presence of bifunctional and/or nucleotidyltransferase enzymes with/without macrolide resistance associated with the msr(A) gene. Most of HLMUPR-MRSA isolates belonged to ST125/t067. Nine IS257-ileS2 amplification patterns (p3 was the most frequent) were observed in HLMUPR-MRSA isolates, suggesting the presence of several mupirocin-resistance-carrying plasmids in our environment and promoting the emergence of mupirocin resistance. The presence of the same IS257-ileS2 amplification pattern p3 in 65% of HLMUPR-MRSA, all of them ST125/t067, suggests a clonal spread in our hospital and community environment which could explain the high prevalence of HLMUPR-MRSA during the study period. An outbreak situation or an increase in mupirocin consumption was not observed. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. The application of high-pressure treatment in the reduction of salt levels in reduced-phosphate breakfast sausages.

    PubMed

    O'Flynn, Claire C; Cruz-Romero, Malco C; Troy, Declan; Mullen, Anne M; Kerry, Joe P

    2014-03-01

    This study investigated the effects of high pressure (HP) treatment of pork meat before manufacturing sausages with reduced salt levels and compared them to sausages manufactured with untreated meat (control sausages). A 2×5 factorial design was set up incorporating two pressure levels (0 or 150 MPa) and five salt levels (0.5, 1.0, 1.5, 2.0 and 2.5%). Most quality attributes were affected when salt levels were reduced below 1.5%. Fat loss (FL) was (P<0.05) affected by salt level; samples with <1.5% salt had the highest FL. HP treatment increased emulsion stability and reduced cook loss (CL) compared to control sausages. Increased CL was observed when salt was reduced below 2.0%. Salt reduction below 1.5% adversely affected colour, sensory and texture attributes. Independent of salt, HP treatment affected adversely juiciness and cohesiveness while adhesiveness was improved. Overall, there is potential to manufacture sausages maintaining organoleptic and functional properties traditionally associated with sausages using HP treated meat. Copyright © 2013 Elsevier Ltd. All rights reserved.

  12. Aurora Activities Observed by SNPP VIIRS Day-Night Band during St. Patrick's Day, 2015 G4 Level Geomagnetic Storm

    NASA Astrophysics Data System (ADS)

    Liu, T. C.; Shao, X.; Cao, C.; Zhang, B.; Fung, S. F.; Sharma, S.

    2015-12-01

    A G4 level (severe) geomagnetic storm occurred on March 17 (St. Patrick's Day), 2015 and it is among the strongest geomagnetic storms of the current solar cycle (Solar Cycle 24). The storm is identified as due to the Coronal Mass Ejections (CMEs) which erupted on March 15 from Region 2297 of solar surface. During this event, the geomagnetic storm index Dst reached -223 nT and the geomagnetic aurora electrojet (AE) index increased and reached as high as >2200 nT with large amplitude fluctuations. Aurora occurred in both hemispheres. Ground auroral sightings were reported from Michigan to Alaska and as far south as southern Colorado. The Day Night Band (DNB) of the Visible Infrared Imaging Radiometer Suite (VIIRS) onboard Suomi-NPP represents a major advancement in night time imaging capabilities. The DNB senses radiance that can span 7 orders of magnitude in one panchromatic (0.5-0.9 μm) reflective solar band and provides imagery of clouds and other Earth features over illumination levels ranging from full sunlight to quarter moon. In this paper, DNB observations of aurora activities during the St. Patrick's Day geomagnetic storm are analyzed. Aurora are observed to evolve with salient features by DNB for orbital pass on the night side (~local time 1:30am) in both hemispheres. The radiance data from DNB observation are collected at the night sides of southern and northern hemispheres and geo-located onto geomagnetic local time (MLT) coordinates. Regions of aurora during each orbital pass are identified through image processing by contouring radiance values and excluding regions with stray light near day-night terminator. The evolution of aurora are characterized with time series of the poleward and low latitude boundary of aurora, their latitude-span and area, peak radiance and total light emission of the aurora region in DNB observation. These characteristic parameters are correlated with solar wind and geomagnetic index parameters.

  13. Using Telescopic Observations to Mentor High School Students in STEM

    NASA Astrophysics Data System (ADS)

    McLin, K. M.; Cominsky, L. R.

    2011-09-01

    Over the past two summers (2009 and 2010) the NASA EPO Group at Sonoma State University (SSU) has sponsored local high school students in a summer science internship program at the University. The students, chosen from Sonoma County high schools in a competitive selection process, work in various science, technology, engineering, and mathematics (STEM) fields throughout the School of Science and Technology at SSU. The two interns sponsored by the EPO Group each summer monitor active galaxies using GORT, the NASA/Fermi-sponsored optical robotic telescope operated by the Group. They are mentored in their projects by EPO Group personnel and by SSU undergraduates who have experience with the telescope. The students learn about the sky, telescopes and the active galaxies they observe. They also learn how to make telescopic observations and how to reduce the CCD images obtained. Interns also participate in weekly meetings with other interns working on different projects around campus. At the end of the summer all the interns present their research results at a symposium held on campus.The symposium is attended by the interns themselves, their parents, their high school science teachers, and university faculty and administrators.The program has had a positive impact on how our interns view science, and specifically on their view of astronomy, as reported by the interns themselves in the first two years of the program.

  14. Using Telescopic Observations to Mentor High School Students in STEM

    NASA Astrophysics Data System (ADS)

    McLin, Kevin M.; Cominsky, Lynn R.

    2011-03-01

    Over the past two summers (2009/2010) the NASA E/PO Group at Sonoma State University has sponsored local high school students in a summer science internship program at the University. The students, chosen from Sonoma County high schools in a competitive selection process, work in various STEM fields throughout the School of Science and Technology at SSU. The two interns sponsored by the E/PO Group each summer use GORT, the NASA/Fermi-sponsored robotic observatory operated by the Group, to monitor active galaxies. They are mentored in their projects by E/PO Group personnel and by SSU undergraduates who have experience with the telescope. The students learn about the sky, telescopes and the active galaxies they observe. They also learn how to make telescopic observations and how to reduce the CCD images obtained. Interns also participate in weekly meetings with other interns working on different projects around campus. At the end of the summer all the interns present their research results at a symposium held on campus.The symposium is attended by the interns themselves, their parents and sponsoring high school science teachers, and university faculty and administrators.The program has had a positive impact on how our interns view science, as reported by themselves, and specifically on their view of astronomy, in the first year of the program.

  15. Enhancement of acid phosphatase secretion and Pi acquisition in Suaeda fruticosa on calcareous soil by high saline level.

    PubMed

    Labidi, Nehla; Snoussi, Sana; Ammari, Manel; Metoui, Wissal; Ben Yousfi, N; Hamrouni, Lamia; Abdelly, C

    2010-12-01

    The aim of this study was to identify the relationship between the adaptive processes of Suaeda fruticosa for Pi acquisition and the physic-chemical and biological characteristics of two soil types under moderate and high saline conditions. Four treatments were established in pots: namely SS100, SS600, CS100 and CS600 where SS stood for sandy soil and CS for calcareous soil, and the indexes 100 and 600 were NaCl concentrations (mM) in irrigation distilled water. Assuming that Pi per g of plant biomass is an indicator of plant efficiency for P acquisition, the results showed that Pi acquisition was easiest on SS100 and was difficult on CS100. The differences in Pi acquisition between plants on SS100 and CS100 could be attributed to the low root surface area (-30%) and to the low alkaline phosphatases (Pases) activities (-50%) in calcareous rhizospheric soil. The high salinity level had no effect on the efficiency of P acquisition on SS but increased this parameter on CS (+50%). In the latter soil type, high acid phosphatase activities were observed in rhizospheric soil at high salinity level. Acid phosphatase seemed to be secreted from the roots. The higher secretion of acid phosphatase in this soil was related to the root lipid peroxidation in response to elevated salinity associated with the augmentation of unsaturated acids which might induce an oxidative damage of the root membrane. Thus we can conclude that in deficient soil such as calcareous, the efficiency of P acquisition in S. fruticosa which was difficult at moderate salinity level can be enhanced by high salinity level.

  16. High Resolution Radio Observations Of Energetically Dominant Regions In Local Luminous Infrared Galaxies

    NASA Astrophysics Data System (ADS)

    Barcos-Munoz, Loreto

    2016-07-01

    Luminous and Ultra-luminous Infrared galaxies (U/LIRGs) are one of the most powerful classes of extragalactic objects in the local universe, and they provide a unique opportunity to study star formation and feedback processes in extreme environments. They are primarily observed to be interacting or merging disk galaxies. During the interaction, large amounts of gas are funneled to the central few kpc, triggering high star formation rates (SFR) and dust production. The absorption of UV and optical radiation from stars, or active galactic nuclei (AGN), by dust produces their observed high infrared luminosities.The high level of dust obscuration intrinsic to U/LIRGs makes them difficult to study. Radio interferometry is thus the perfect tool for revealing the nature of these systems - it provides the high spatial resolution needed to resolve energetically dominant regions in U/LIRGs at wavelengths that have both diagnostic power and transparency to dust. In this thesis, 6 and 33 GHz radio continuum interferometric observations with the upgraded Karl G. Jansky Very Large Array (VLA) are used to study a sample of 22 local U/LIRGs.First, a detailed analysis of the 6 and 33 GHz radio continuum emission from the closest ULIRG, Arp 220, is presented. This late stage merger is highly obscured, being optically thick even at mid-infrared wavelengths. Further, due to its extreme environment, it is often used as a template for high redshift starbursts. Arp 220 hosts two distinct nuclei that are separated by (\\sim) 370 pc. The nuclei are well resolved with the 33 GHz observations (i.e., with a spatial resolution of ˜ 30 pc). The deconvolved radii enclosing half of the total 33 GHz light are approximately 50 and 35 pc for the eastern and western nucleus, respectively. Literature values of the gas mass and infrared luminosity are combined with the 33 GHz sizes under the assumption of co-spatiality to show that Arp 220 has one of the highest molecular gas surface densities

  17. Can we use Earth Observations to improve monthly water level forecasts?

    NASA Astrophysics Data System (ADS)

    Slater, L. J.; Villarini, G.

    2017-12-01

    Dynamical-statistical hydrologic forecasting approaches benefit from different strengths in comparison with traditional hydrologic forecasting systems: they are computationally efficient, can integrate and `learn' from a broad selection of input data (e.g., General Circulation Model (GCM) forecasts, Earth Observation time series, teleconnection patterns), and can take advantage of recent progress in machine learning (e.g. multi-model blending, post-processing and ensembling techniques). Recent efforts to develop a dynamical-statistical ensemble approach for forecasting seasonal streamflow using both GCM forecasts and changing land cover have shown promising results over the U.S. Midwest. Here, we use climate forecasts from several GCMs of the North American Multi Model Ensemble (NMME) alongside 15-minute stage time series from the National River Flow Archive (NRFA) and land cover classes extracted from the European Space Agency's Climate Change Initiative 300 m annual Global Land Cover time series. With these data, we conduct systematic long-range probabilistic forecasting of monthly water levels in UK catchments over timescales ranging from one to twelve months ahead. We evaluate the improvement in model fit and model forecasting skill that comes from using land cover classes as predictors in the models. This work opens up new possibilities for combining Earth Observation time series with GCM forecasts to predict a variety of hazards from space using data science techniques.

  18. Horizontal tuning for faces originates in high-level Fusiform Face Area.

    PubMed

    Goffaux, Valerie; Duecker, Felix; Hausfeld, Lars; Schiltz, Christine; Goebel, Rainer

    2016-01-29

    Recent work indicates that the specialization of face visual perception relies on the privileged processing of horizontal angles of facial information. This suggests that stimulus properties assumed to be fully resolved in primary visual cortex (V1; e.g., orientation) in fact determine human vision until high-level stages of processing. To address this hypothesis, the present fMRI study explored the orientation sensitivity of V1 and high-level face-specialized ventral regions such as the Occipital Face Area (OFA) and Fusiform Face Area (FFA) to different angles of face information. Participants viewed face images filtered to retain information at horizontal, vertical or oblique angles. Filtered images were viewed upright, inverted and (phase-)scrambled. FFA responded most strongly to the horizontal range of upright face information; its activation pattern reliably separated horizontal from oblique ranges, but only when faces were upright. Moreover, activation patterns induced in the right FFA and the OFA by upright and inverted faces could only be separated based on horizontal information. This indicates that the specialized processing of upright face information in the OFA and FFA essentially relies on the encoding of horizontal facial cues. This pattern was not passively inherited from V1, which was found to respond less strongly to horizontal than other orientations likely due to adaptive whitening. Moreover, we found that orientation decoding accuracy in V1 was impaired for stimuli containing no meaningful shape. By showing that primary coding in V1 is influenced by high-order stimulus structure and that high-level processing is tuned to selective ranges of primary information, the present work suggests that primary and high-level levels of the visual system interact in order to modulate the processing of certain ranges of primary information depending on their relevance with respect to the stimulus and task at hand. Copyright © 2015 Elsevier Ltd. All rights

  19. Corrosion of high-level radioactive waste iron-canisters in contact with bentonite.

    PubMed

    Kaufhold, Stephan; Hassel, Achim Walter; Sanders, Daniel; Dohrmann, Reiner

    2015-03-21

    Several countries favor the encapsulation of high-level radioactive waste (HLRW) in iron or steel canisters surrounded by highly compacted bentonite. In the present study the corrosion of iron in contact with different bentonites was investigated. The corrosion product was a 1:1 Fe layer silicate already described in literature (sometimes referred to as berthierine). Seven exposition test series (60 °C, 5 months) showed slightly less corrosion for the Na-bentonites compared to the Ca-bentonites. Two independent exposition tests with iron pellets and 38 different bentonites clearly proved the role of the layer charge density of the swelling clay minerals (smectites). Bentonites with high charged smectites are less corrosive than bentonites dominated by low charged ones. The type of counterion is additionally important because it determines the density of the gel and hence the solid/liquid ratio at the contact to the canister. The present study proves that the integrity of the multibarrier-system is seriously affected by the choice of the bentonite buffer encasing the metal canisters in most of the concepts. In some tests the formation of a patina was observed consisting of Fe-silicate. Up to now it is not clear why and how the patina formed. It, however, may be relevant as a corrosion inhibitor. Copyright © 2014 Elsevier B.V. All rights reserved.

  20. Using Clinically Accessible Tools to Measure Sound Levels and Sleep Disruption in the ICU: A Prospective Multicenter Observational Study.

    PubMed

    Litton, Edward; Elliott, Rosalind; Thompson, Kelly; Watts, Nicola; Seppelt, Ian; Webb, Steven A R

    2017-06-01

    To use clinically accessible tools to determine unit-level and individual patient factors associated with sound levels and sleep disruption in a range of representative ICUs. A cross-sectional, observational study. Australian and New Zealand ICUs. All patients 16 years or over occupying an ICU bed on one of two Point Prevalence study days in 2015. Ambient sound was measured for 1 minute using an application downloaded to a personal mobile device. Bedside nurses also recorded the total time and number of awakening for each patient overnight. The study included 539 participants with sound level recorded using an application downloaded to a personal mobile device from 39 ICUs. Maximum and mean sound levels were 78 dB (SD, 9) and 62 dB (SD, 8), respectively. Maximum sound levels were higher in ICUs with a sleep policy or protocol compared with those without maximum sound levels 81 dB (95% CI, 79-83) versus 77 dB (95% CI, 77-78), mean difference 4 dB (95% CI, 0-2), p < 0.001. There was no significant difference in sound levels regardless of single room occupancy, mechanical ventilation status, or illness severity. Clinical nursing staff in all 39 ICUs were able to record sleep assessment in 15-minute intervals. The median time awake and number of prolonged disruptions were 3 hours (interquartile range, 1-4) and three (interquartile range, 2-5), respectively. Across a large number of ICUs, patients were exposed to high sound levels and substantial sleep disruption irrespective of factors including previous implementation of a sleep policy. Sound and sleep measurement using simple and accessible tools can facilitate future studies and could feasibly be implemented into clinical practice.