observed pressure response: Topics by Science.gov

Long-term Response of Cerebrospinal Fluid Pressure in Patients with Idiopathic Intracranial Hypertension - A Prospective Observational Study.

PubMed

Gafoor, V Abdul; Smita, B; Jose, James

2017-01-01

Idiopathic intracranial hypertension (IIH) is increased intracranial pressure (ICP) with normal cerebrospinal fluid (CSF) contents, in the absence of an intracranial mass, hydrocephalus, or other identifiable causes. The current knowledge of the treatment outcome of IIH is limited, and the data on the natural history of this entity are scant. The objective of the study is to study the treatment response of IIH by serially measuring the CSF opening pressure and to delineate the factors influencing the same. A prospective observational study in a cohort of fifty patients with IIH in whom CSF opening pressure was serially measured at pre-specified intervals. The mean CSF opening pressure at baseline was 302.4 ± 51.69 mm of H 2 O (range: 220-410). Even though a higher body mass index (BMI) showed a trend toward a higher CSF opening pressure, the association was not significant ( P = 0.168). However, the age of the patient had a significant negative correlation with the CSF pressure ( P = 0.006). The maximum reduction in CSF pressure occurred in the first 3 months of treatment, and thereafter it plateaued. Remission was attained in 12 (24%) patients. BMI had the strongest association with remission ( P = 0.001). In patients with IIH, treatment response is strongly related to BMI. However, patients with normal BMI are also shown to relapse and hence should have continuous, long-term follow-up. The reduction in CSF pressure attained in the first 3 months could reflect the long-term response to treatment.
Observations of wave-induced pore pressure gradients and bed level response on a surf zone sandbar

NASA Astrophysics Data System (ADS)

Anderson, Dylan; Cox, Dan; Mieras, Ryan; Puleo, Jack A.; Hsu, Tian-Jian

2017-06-01

Horizontal and vertical pressure gradients may be important physical mechanisms contributing to onshore sediment transport beneath steep, near-breaking waves in the surf zone. A barred beach was constructed in a large-scale laboratory wave flume with a fixed profile containing a mobile sediment layer on the crest of the sandbar. Horizontal and vertical pore pressure gradients were obtained by finite differences of measurements from an array of pressure transducers buried within the upper several centimeters of the bed. Colocated observations of erosion depth were made during asymmetric wave trials with wave heights between 0.10 and 0.98 m, consistently resulting in onshore sheet flow sediment transport. The pore pressure gradient vector within the bed exhibited temporal rotations during each wave cycle, directed predominantly upward under the trough and then rapidly rotating onshore and downward as the wavefront passed. The magnitude of the pore pressure gradient during each phase of rotation was correlated with local wave steepness and relative depth. Momentary bed failures as deep as 20 grain diameters were coincident with sharp increases in the onshore-directed pore pressure gradients, but occurred at horizontal pressure gradients less than theoretical critical values for initiation of the motion for compact beds. An expression combining the effects of both horizontal and vertical pore pressure gradients with bed shear stress and soil stability is used to determine that failure of the bed is initiated at nonnegligible values of both forces.Plain Language SummaryThe pressure gradient present within the seabed beneath breaking waves may be an important physical mechanism transporting sediment. A large-scale laboratory was used to replicate realistic surfzone conditions in controlled tests, allowing for horizontal and vertical pressure gradient magnitudes and the resulting sediment bed response to be observed with </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AGUFMSM11B2312S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AGUFMSM11B2312S">Vortex, ULF wave and Aurora Observation after Solar Wind Dynamic Pressure Change</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Shi, Q. 2017-12-01 Here we will summarize our recent study and show some new results on the Magnetosphere and Ionosphere Response to Dynamic Pressure Change/disturbances in the Solar Wind and foreshock regions. We study the step function type solar wind dynamic pressure change (increase/decrease) interaction with the magnetosphere using THEMIS satellites at both dayside and nightside in different geocentric distances. Vortices generated by the dynamic pressure change passing along the magnetopause are found and compared with model predictions. ULF waves and vortices are excited in the dayside and nightside plasma sheet when dynamic pressure change hit the magnetotail. The related ionospheric responses, such as aurora and TCVs, are also investigated. We compare Global MHD simulations with the observations. We will also show some new results that dayside magnetospheric FLRs might be caused by foreshock structures.Shi, Q. Q. et al. (2013), THEMIS observations of ULF wave excitation in the nightside plasma sheet during sudden impulse events, J. Geophys. Res. Space Physics, 118, doi:10.1029/2012JA017984. Shi, Q. Q. et al. (2014), Solar wind pressure pulse-driven magnetospheric vortices and their global consequences, J. Geophys. Res. Space Physics, 119, doi:10.1002/2013JA019551. Tian, A.M. et al.(2016), Dayside magnetospheric and ionospheric responses to solar wind pressure increase: Multispacecraft and ground observations, J. Geophys. Res., 121, doi:10.1002/2016JA022459. Shen, X.C. et al.(2015), Magnetospheric ULF waves with increasing amplitude related to solar wind dynamic pressure changes: THEMIS observations, J. Geophys. Res., 120, doi:10.1002/2014JA020913Zhao, H. Y. et al. (2016), Magnetospheric vortices and their global effect after a solar wind dynamic pressure decrease, J. Geophys. Res. Space Physics, 121, doi:10.1002/2015JA021646. Shen, X. C., et al. (2017), Dayside magnetospheric ULF wave frequency modulated by a solar wind dynamic pressure negative impulse, J. Geophys. Res </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/3980383','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/3980383">Arterial blood pressure response to heavy resistance exercise.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> MacDougall, J D; Tuxen, D; Sale, D G; Moroz, J R; Sutton, J R 1985-03-01 The purpose of this study was to record the blood pressure response to heavy weight-lifting exercise in five experienced body builders. Blood pressure was directly recorded by means of a capacitance transducer connected to a catheter in the brachial artery. Intrathoracic pressure with the Valsalva maneuver was recorded as mouth pressure by having the subject maintain an open glottis while expiring against a column of Hg during the lifts. Exercises included single-arm curls, overhead presses, and both double- and single-leg presses performed to failure at 80, 90, 95, and 100% of maximum. Systolic and diastolic blood pressures rose rapidly to extremely high values during the concentric contraction phase for each lift and declined with the eccentric contraction. The greatest peak pressures occurred during the double-leg press where the mean value for the group was 320/250 mmHg, with pressures in one subject exceeding 480/350 mmHg. Peak pressures with the single-arm curl exercise reached a mean group value of 255/190 mmHg when repetitions were continued to failure. Mouth pressures of 30-50 Torr during a single maximum lift, or as subjects approached failure with a submaximal weight, indicate that a portion of the observed increase in blood pressure was caused by a Valsalva maneuver. It was concluded that when healthy young subjects perform weight-lifting exercises the mechanical compression of blood vessels combines with a potent pressor response and a Valsalva response to produce extreme elevations in blood pressure. Pressures are extreme even when exercise is performed with a relatively small muscle mass. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27723794','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27723794">The Intracranial Volume Pressure Response in Increased Intracranial Pressure Patients: Clinical Significance of the Volume Pressure Indicator.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Lai, Hung-Yi; Lee, Ching-Hsin; Lee, Ching-Yi 2016-01-01 For patients suffering from primary brain injury, monitoring intracranial pressure alone is not enough to reflect the dynamic intracranial condition. In our previous study, a segment of the pressure-volume curve can be expressed by the parabolic regression model with single indicator "a". The aim of this study is to evaluate if the indicator "a" can reflect intracranial conditions. Patients with traumatic brain injury, spontaneous intracranial hemorrhage, and/or hydrocephalus who had external ventricular drainage from January 2009 to February 2010 were included. The successive volume pressure response values were obtained by successive drainage of cerebral spinal fluid from intracranial pressure 20-25 mm Hg to 10 mm Hg. The relationship between withdrawn cerebral spinal fluid volume and intracranial pressure was analyzed by the parabolic regression model with single parameter "a". The overall mean for indicator "a" was 0.422 ± 0.046. The mean of "a" in hydrocephalus was 0.173 ± 0.024 and in severe intracranial mass with slender ventricle, it was 0.663 ± 0.062. The two extreme intracranial conditions had a statistical significant difference (p<0.001). The indicator "a" of a pressure-volume curve can reflect the dynamic intracranial condition and is comparable in different situations. A significantly larger indicator "a" with increased intracranial pressure is always observed in severe intracranial mass lesions with cerebral edema. A significantly smaller indicator "a" with increased intracranial pressure is observed in hydrocephalus. Brain computed tomography should be performed early if a rapid elevation of indicator "a" is detected, as it can reveal some ongoing intracranial pathology prior to clinical deterioration. Increased intracranial pressure was frequently observed in patients with intracranial pathology. The progression can be differentiated using the pattern of the volume pressure indicator. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5056694','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5056694">The Intracranial Volume Pressure Response in Increased Intracranial Pressure Patients: Clinical Significance of the Volume Pressure Indicator</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> 2016-01-01 Background For patients suffering from primary brain injury, monitoring intracranial pressure alone is not enough to reflect the dynamic intracranial condition. In our previous study, a segment of the pressure-volume curve can be expressed by the parabolic regression model with single indicator “a”. The aim of this study is to evaluate if the indicator “a” can reflect intracranial conditions. Methods Patients with traumatic brain injury, spontaneous intracranial hemorrhage, and/or hydrocephalus who had external ventricular drainage from January 2009 to February 2010 were included. The successive volume pressure response values were obtained by successive drainage of cerebral spinal fluid from intracranial pressure 20–25 mm Hg to 10 mm Hg. The relationship between withdrawn cerebral spinal fluid volume and intracranial pressure was analyzed by the parabolic regression model with single parameter “a”. Results The overall mean for indicator “a” was 0.422 ± 0.046. The mean of “a” in hydrocephalus was 0.173 ± 0.024 and in severe intracranial mass with slender ventricle, it was 0.663 ± 0.062. The two extreme intracranial conditions had a statistical significant difference (p<0.001). Conclusion The indicator “a” of a pressure-volume curve can reflect the dynamic intracranial condition and is comparable in different situations. A significantly larger indicator “a” with increased intracranial pressure is always observed in severe intracranial mass lesions with cerebral edema. A significantly smaller indicator “a” with increased intracranial pressure is observed in hydrocephalus. Brain computed tomography should be performed early if a rapid elevation of indicator “a” is detected, as it can reveal some ongoing intracranial pathology prior to clinical deterioration. Increased intracranial pressure was frequently observed in patients with intracranial pathology. The progression can be differentiated using the pattern of the volume </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2010HPR....30..118K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2010HPR....30..118K">Observations of a high-pressure phase creation in oleic acid</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Kościesza, R.; Kulisiewicz, L.; Delgado, A. 2010-03-01 Oleic acid is one of the unsaturated fatty acids which frequently appears in food products such as edible fats and oils. A molecule of oleic acid possesses a double carbon bond, C=C, which is responsible for a transition to a new phase when pressure is applied. This work presents the results of optical observations of such a transition. The observations were made in two cases, the first being static p-T conditions under 60 MPa at 20°C and the other the dynamic application of the pressure up to 350 MPa. The obtained visualization reveals differences in the creation of the phase and in its further appearance. Some crystal forms may be recognized. These results tend to be of interest for food engineers due to increasing interest in high-pressure food preservation among nutritionists and medical scientists concerned with fatty acids. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5660688','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5660688">Non-linear Heart Rate and Blood Pressure Interaction in Response to Lower-Body Negative Pressure</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Verma, Ajay K.; Xu, Da; Garg, Amanmeet; Cote, Anita T.; Goswami, Nandu; Blaber, Andrew P.; Tavakolian, Kouhyar 2017-01-01 Early detection of hemorrhage remains an open problem. In this regard, blood pressure has been an ineffective measure of blood loss due to numerous compensatory mechanisms sustaining arterial blood pressure homeostasis. Here, we investigate the feasibility of causality detection in the heart rate and blood pressure interaction, a closed-loop control system, for early detection of hemorrhage. The hemorrhage was simulated via graded lower-body negative pressure (LBNP) from 0 to −40 mmHg. The research hypothesis was that a significant elevation of causal control in the direction of blood pressure to heart rate (i.e., baroreflex response) is an early indicator of central hypovolemia. Five minutes of continuous blood pressure and electrocardiogram (ECG) signals were acquired simultaneously from young, healthy participants (27 ± 1 years, N = 27) during each LBNP stage, from which heart rate (represented by RR interval), systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) were derived. The heart rate and blood pressure causal interaction (RR↔SBP and RR↔MAP) was studied during the last 3 min of each LBNP stage. At supine rest, the non-baroreflex arm (RR→SBP and RR→MAP) showed a significantly (p < 0.001) higher causal drive toward blood pressure regulation compared to the baroreflex arm (SBP→RR and MAP→RR). In response to moderate category hemorrhage (−30 mmHg LBNP), no change was observed in the traditional marker of blood loss i.e., pulse pressure (p = 0.10) along with the RR→SBP (p = 0.76), RR→MAP (p = 0.60), and SBP→RR (p = 0.07) causality compared to the resting stage. Contrarily, a significant elevation in the MAP→RR (p = 0.004) causality was observed. In accordance with our hypothesis, the outcomes of the research underscored the potential of compensatory baroreflex arm (MAP→RR) of the heart rate and blood pressure interaction toward differentiating a simulated moderate category hemorrhage from </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014JCAP...08..049N','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014JCAP...08..049N">How does pressure gravitate? Cosmological constant problem confronts observational cosmology</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Narimani, Ali; Afshordi, Niayesh; Scott, Douglas 2014-08-01 An important and long-standing puzzle in the history of modern physics is the gross inconsistency between theoretical expectations and cosmological observations of the vacuum energy density, by at least 60 orders of magnitude, otherwise known as the cosmological constant problem. A characteristic feature of vacuum energy is that it has a pressure with the same amplitude, but opposite sign to its energy density, while all the precision tests of General Relativity are either in vacuum, or for media with negligible pressure. Therefore, one may wonder whether an anomalous coupling to pressure might be responsible for decoupling vacuum from gravity. We test this possibility in the context of the Gravitational Aether proposal, using current cosmological observations, which probe the gravity of relativistic pressure in the radiation era. Interestingly, we find that the best fit for anomalous pressure coupling is about half-way between General Relativity (GR), and Gravitational Aether (GA), if we include Planck together with WMAP and BICEP2 polarization cosmic microwave background (CMB) observations. Taken at face value, this data combination excludes both GR and GA at around the 3 σ level. However, including higher resolution CMB observations (``highL'') or baryonic acoustic oscillations (BAO) pushes the best fit closer to GR, excluding the Gravitational Aether solution to the cosmological constant problem at the 4- 5 σ level. This constraint effectively places a limit on the anomalous coupling to pressure in the parametrized post-Newtonian (PPN) expansion, ζ4 = 0.105 ± 0.049 (+highL CMB), or ζ4 = 0.066 ± 0.039 (+BAO). These represent the most precise measurement of this parameter to date, indicating a mild tension with GR (for ΛCDM including tensors, with 0ζ4=), and also among different data sets. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23084132','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23084132">Central venous pressure and shock index predict lack of hemodynamic response to volume expansion in septic shock: a prospective, observational study.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Lanspa, Michael J; Brown, Samuel M; Hirshberg, Eliotte L; Jones, Jason P; Grissom, Colin K 2012-12-01 Volume expansion is a common therapeutic intervention in septic shock, although patient response to the intervention is difficult to predict. Central venous pressure (CVP) and shock index have been used independently to guide volume expansion, although their use is questionable. We hypothesize that a combination of these measurements will be useful. In a prospective, observational study, patients with early septic shock received 10-mL/kg volume expansion at their treating physician's discretion after brief initial resuscitation in the emergency department. Central venous pressure and shock index were measured before volume expansion interventions. Cardiac index was measured immediately before and after the volume expansion using transthoracic echocardiography. Hemodynamic response was defined as an increase in a cardiac index of 15% or greater. Thirty-four volume expansions were observed in 25 patients. A CVP of 8 mm Hg or greater and a shock index of 1 beat min(-1) mm Hg(-1) or less individually had a good negative predictive value (83% and 88%, respectively). Of 34 volume expansions, the combination of both a high CVP and a low shock index was extremely unlikely to elicit hemodynamic response (negative predictive value, 93%; P = .02). Volume expansion in patients with early septic shock with a CVP of 8 mm Hg or greater and a shock index of 1 beat min(-1) mm Hg(-1) or less is unlikely to lead to an increase in cardiac index. Copyright © 2012 Elsevier Inc. All rights reserved. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5707624','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5707624">Pressure-Responsive, Surfactant-Free CO2-Based Nanostructured Fluids</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> 2017-01-01 Microemulsions are extensively used in advanced material and chemical processing. However, considerable amounts of surfactant are needed for their formulation, which is a drawback due to both economic and ecological reasons. Here, we describe the nanostructuration of recently discovered surfactant-free, carbon dioxide (CO2)-based microemulsion-like systems in a water/organic-solvent/CO2 pressurized ternary mixture. “Water-rich” nanodomains embedded into a “water-depleted” matrix have been observed and characterized by the combination of Raman spectroscopy, molecular dynamics simulations, and small-angle neutron scattering. These single-phase fluids show a reversible, pressure-responsive nanostructuration; the “water-rich” nanodomains at a given pressure can be instantaneously degraded/expanded by increasing/decreasing the pressure, resulting in a reversible, rapid, and homogeneous mixing/demixing of their content. This pressure-triggered responsiveness, together with other inherent features of these fluids, such as the absence of any contaminant in the ternary mixture (e.g., surfactant), their spontaneous formation, and their solvation capability (enabling the dissolution of both hydrophobic and hydrophilic molecules), make them appealing complex fluid systems to be used in molecular material processing and in chemical engineering. PMID:28846386 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/6117','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/6117">Tritiated Water on Molecular Sieve: Water Dynamics and Pressure Observations</a> <a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a> Walters, R.T. 1999-04-23 The production of fusion energy in a Tokamak using deuterium and tritium requires the safe handling and processing of exhaust gases that contain various amounts of tritium. Initial operation of the Tokamak Fusion Test Reactor (TFTR), Princeton Plasma Physics Laboratory, oxidized exhaust gases for tritium recovery or long-term storage. One of the most efficient and safest ways to contain tritiated water is to sorb it onto a pelletized 4A molecular sieve. A Disposable Molecular Sieve Bed (DMSB) was designed as a pressure vessel because of the possibility of pressure generation from the radiolysis of tritiated water on molecular sieve. Hydrogenmore » production contributes to the complexity of the containers used to transport and store tritiated water, and increases the fabrication costs. Two months after removing a DMSB from the process at TFTR, a pressure in excess of that predicted from self-radiolysis was observed. Interestingly, pressure measurements at longer times (up to 2.5 years) showed less pressure than expected. Pressure was not being generated in the DMSBs at the predicted rate. This was unexpected and prompted an investigation into the mechanism responsible for the anomalous pressure measurements.« less </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19790039457&hterms=Blood+pressure&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3DBlood%2Bpressure','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19790039457&hterms=Blood+pressure&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3DBlood%2Bpressure">Cardiovascular regulatory response to lower body negative pressure following blood volume loss</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Shimizu, M.; Ghista, D. N.; Sandler, H. 1979-01-01 An attempt is made to explain the cardiovascular regulatory responses to lower body negative pressure (LBNP) stress, both in the absence of and following blood or plasma volume loss, the latter being factors regularly observed with short- or long-term recumbency or weightlessness and associated with resulting cardiovascular deconditioning. Analytical expressions are derived for the responses of mean venous pressure and blood volume pooled in the lower body due to LBNP. An analysis is presented for determining the HR change due to LBNP stress following blood volume loss. It is concluded that the reduced orthostatic tolerance following long-term space flight or recumbency can be mainly attributed to blood volume loss, and that the associated cardiovascular responses characterizing this orthostatic intolerance is elicited by the associated central venous pressure response. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/9102186','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/9102186">Cerebral blood flow changes in response to elevated intracranial pressure in rabbits and bluefish: a comparative study.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Beiner, J M; Olgivy, C S; DuBois, A B 1997-03-01 In mammals, the cerebrovascular response to increases in intracranial pressure may take the form of the Cushing response, which includes increased mean systemic arterial pressure, bradycardia and diminished respirations. The mechanism, effect and value of these responses are debated. Using laser-Doppler flowmetry to measure cerebral blood flow, we analyzed the cardiovascular responses to intracranial pressure raised by epidural infusion of mock cerebrospinal fluid in the bluefish and in the rabbit, and compare the results. A decline in cerebral blood flow preceding a rise in mean systemic arterial pressure was observed in both species. Unlike bluefish, rabbits exhibit a threshold of intracranial pressure below which cerebral blood flow was maintained and no cardiovascular changes were observed. The difference in response between the two species was due to the presence of an active autoregulatory system in the cerebral tissue of rabbits and its absence in bluefish. For both species studied, the stimulus for the Cushing response seems to be a decrement in cerebral blood flow. The resulting increase in the mean systemic arterial pressure restores cerebral blood flow to levels approaching controls. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://pubs.er.usgs.gov/publication/70155511','USGSPUBS'); return false;" href="https://pubs.er.usgs.gov/publication/70155511">Pore-pressure sensitivities to dynamic strains: observations in active tectonic regions</a> <a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a> Barbour, Andrew J. 2015-01-01 Triggered seismicity arising from dynamic stresses is often explained by the Mohr-Coulomb failure criterion, where elevated pore pressures reduce the effective strength of faults in fluid-saturated rock. The seismic response of a fluid-rock system naturally depends on its hydro-mechanical properties, but accurately assessing how pore-fluid pressure responds to applied stress over large scales in situ remains a challenging task; hence, spatial variations in response are not well understood, especially around active faults. Here I analyze previously unutilized records of dynamic strain and pore-pressure from regional and teleseismic earthquakes at Plate Boundary Observatory (PBO) stations from 2006 through 2012 to investigate variations in response along the Pacific/North American tectonic plate boundary. I find robust scaling-response coefficients between excess pore pressure and dynamic strain at each station that are spatially correlated: around the San Andreas and San Jacinto fault systems, the response is lowest in regions of the crust undergoing the highest rates of secular shear strain. PBO stations in the Parkfield instrument cluster are at comparable distances to the San Andreas fault (SAF), and spatial variations there follow patterns in dextral creep rates along the fault, with the highest response in the actively creeping section, which is consistent with a narrowing zone of strain accumulation seen in geodetic velocity profiles. At stations in the San Juan Bautista (SJB) and Anza instrument clusters, the response depends non-linearly on the inverse fault-perpendicular distance, with the response decreasing towards the fault; the SJB cluster is at the northern transition from creeping-to-locked behavior along the SAF, where creep rates are at moderate to low levels, and the Anza cluster is around the San Jacinto fault, where to date there have been no statistically significant creep rates observed at the surface. These results suggest that the strength </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2005MeScT..16.1751P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2005MeScT..16.1751P">Dynamic calibration of fast-response probes in low-pressure shock tubes</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Persico, G.; Gaetani, P.; Guardone, A. 2005-09-01 Shock tube flows resulting from the incomplete burst of the diaphragm are investigated in connection with the dynamic calibration of fast-response pressure probes. As a result of the partial opening of the diaphragm, pressure disturbances are observed past the shock wave and the measured total pressure profile deviates from the envisaged step signal required by the calibration process. Pressure oscillations are generated as the initially normal shock wave diffracts from the diaphragm's orifice and reflects on the shock tube walls, with the lowest local frequency roughly equal to the ratio of the sound speed in the perturbed region to the shock tube diameter. The energy integral of the perturbations decreases with increasing distance from the diaphragm, as the diffracted leading shock and downwind reflections coalesce into a single normal shock. A procedure is proposed to calibrate fast-response pressure probes downwind of a partially opened shock tube diaphragm. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018DSRI..132....6Z','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018DSRI..132....6Z">Near 7-day response of ocean bottom pressure to atmospheric surface pressure and winds in the northern South China Sea</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Zhang, Kun; Zhu, Xiao-Hua; Zhao, Ruixiang 2018-02-01 Ocean bottom pressures, observed by five pressure-recording inverted echo sounders (PIESs) from October 2012 to July 2014, exhibit strong near 7-day variability in the northern South China Sea (SCS) where long-term in situ bottom pressure observations are quite sparse. This variability was strongest in October 2013 during the near two years observation period. By joint analysis with European Center for Medium-Range Weather Forecasts (ECMWF) data, it is shown that the near 7-day ocean bottom pressure variability is closely related to the local atmospheric surface pressure and winds. Within a period band near 7 days, there are high coherences, exceeding 95% significance level, of observed ocean bottom pressure with local atmospheric surface pressure and with both zonal and meridional components of the wind. Ekman pumping/suction caused by the meridional component of the wind in particular, is suggested as one driving mechanism. A Kelvin wave response to the near 7-day oscillation would propagate down along the continental slope, observed at the Qui Nhon in the Vietnam. By multiple and partial coherence analyses, we find that local atmospheric surface pressure and Ekman pumping/suction show nearly equal influence on ocean bottom pressure variability at near 7-day periods. A schematic diagram representing an idealized model gives us a possible mechanism to explain the relationship between ocean bottom pressure and local atmospheric forcing at near 7-day periods in the northern SCS. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29044205','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29044205">Gender Differences in Behavioral and Neural Responses to Unfairness Under Social Pressure.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Zheng, Li; Ning, Reipeng; Li, Lin; Wei, Chunli; Cheng, Xuemei; Zhou, Chu; Guo, Xiuyan 2017-10-18 Numerous studies have revealed the key role of social pressure on individuals' decision-making processes. However, the impact of social pressure on unfairness-related decision-making processes remains unclear. In the present study, we investigated how social pressure modulated men's and women's responses in an ultimatum game. Twenty women and eighteen men played the ultimatum game as responders in the scanner, where fair and unfair offers were tendered by proposers acting alone (low pressure) or by proposers endorsed by three supporters (high pressure). Results showed that men rejected more, whereas women accepted more unfair offers in the high versus low pressure context. Neurally, pregenual anterior cingulate cortex activation in women positively predicted their acceptance rate difference between contexts. In men, stronger right anterior insula activation and increased connectivity between right anterior insula and dorsal anterior cingulate cortex were observed when they receiving unfair offers in the high than low pressure context. Furthermore, more bilateral anterior insula and left dorsolateral prefrontal cortex activations were found when men rejected (relative to accepted) unfair offers in the high than low pressure context. These findings highlighted gender differences in the modulation of behavioral and neural responses to unfairness by social pressure. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=106069','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=106069">Adaptive Changes in Membrane Lipids of Barophilic Bacteria in Response to Changes in Growth Pressure</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Yano, Yutaka; Nakayama, Akihiko; Ishihara, Kenji; Saito, Hiroaki 1998-01-01 The lipid compositions of barophilic bacterial strains which contained docosahexaenoic acid (DHA [22:6n-3]) were examined, and the adaptive changes of these compositions were analyzed in response to growth pressure. In the facultatively barophilic strain 16C1, phosphatidylethanolamine (PE) and phosphatidylglycerol (PG) were major components which had the same fatty acid chains. However, in PE, monounsaturated fatty acids such as hexadecenoic acid were major components, and DHA accounted for only 3.7% of the total fatty acids, while in PG, DHA accounted for 29.6% of the total fatty acids. In response to an increase in growth pressure in strain 16C1, the amounts of saturated fatty acids in PE were reduced, and these decreases were mainly balanced by an increase in unsaturated fatty acids, including DHA. In PG, the decrease in saturated fatty acids was mainly balanced by an increase in DHA. Similar adaptive changes in fatty acid composition were observed in response to growth pressure in obligately barophilic strain 2D2. Furthermore, these adaptive changes in response were also observed in response to low temperature in strain 16C1. These results confirm that the general shift from saturated to unsaturated fatty acids including DHA is one of the adaptive changes in response to increases in pressure and suggest that DHA may play a role in maintaining the proper fluidity of membrane lipids under high pressure. PMID:16349499 </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017ShWav.tmp..136L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017ShWav.tmp..136L">Transient response of a liquid injector to a steep-fronted transverse pressure wave</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Lim, D.; Heister, S.; Stechmann, D.; Kan, B. 2017-12-01 Motivated by the dynamic injection environment posed by unsteady pressure gain combustion processes, an experimental apparatus was developed to visualize the dynamic response of a transparent liquid injector subjected to a single steep-fronted transverse pressure wave. Experiments were conducted at atmospheric pressure with a variety of acrylic injector passage designs using water as the working fluid. High-speed visual observations were made of the injector exit near field, and the extent of backflow and the time to refill the orifice passage were characterized over a range of injection pressures. A companion transient one-dimensional model was developed for interpretation of the results and to elucidate the trends with regard to the strength of the transverse pressure wave. Results from the model were compared with the experimental observations. </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li class="active">1</li> <li><a href="#" onclick='return showDiv("page_2");'>2</a></li> <li><a href="#" onclick='return showDiv("page_3");'>3</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_2" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_1");'>1</a></li> <li class="active">2</li> <li><a href="#" onclick='return showDiv("page_3");'>3</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="21"> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018ShWav..28..919L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018ShWav..28..919L">Transient response of a liquid injector to a steep-fronted transverse pressure wave</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Lim, D.; Heister, S.; Stechmann, D.; Kan, B. 2018-07-01 Motivated by the dynamic injection environment posed by unsteady pressure gain combustion processes, an experimental apparatus was developed to visualize the dynamic response of a transparent liquid injector subjected to a single steep-fronted transverse pressure wave. Experiments were conducted at atmospheric pressure with a variety of acrylic injector passage designs using water as the working fluid. High-speed visual observations were made of the injector exit near field, and the extent of backflow and the time to refill the orifice passage were characterized over a range of injection pressures. A companion transient one-dimensional model was developed for interpretation of the results and to elucidate the trends with regard to the strength of the transverse pressure wave. Results from the model were compared with the experimental observations. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21877145','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21877145">The intraocular pressure response to dehydration: a pilot study.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Hunt, Andrew P; Feigl, Beatrix; Stewart, Ian B 2012-05-01 The aim of this study was to determine the intraocular pressure response to differing levels of dehydration. Seven males participated in 90 min of treadmill walking (5 km h(-1) and 1% grade) in both temperate (22 °C) and hot (43 °C) conditions. At baseline and 30 min intervals intraocular pressure, nude body mass, body temperature and heart rate were recorded. Statistically significant interactions (p < 0.05) were observed for intraocular pressure (hot condition: baseline 17.0 ± 2.9, 30 min 15.6 ± 3.5, 60 min 14.5 ± 3.7 and 90 min 13.6 ± 2.9 mmHg; temperate condition: baseline 16.8 ± 2.7, 30 min 16.5 ± 2.6, 60 min 15.8 ± 2.5 and 90 min 15.7 ± 1.8 mmHg) and body mass loss (hot condition: 30 min -1.07 ± 0.35, 60 min -2.17 ± 0.55 and 90 min -3.13 ± 0.74%; temperate condition: 30 min -0.15 ± 0.11, 60 min -0.47 ± 0.18 and 90 min -0.78 ± 0.25%). Significant linear regressions (p < 0.05) were observed for intraocular pressure and body mass loss (adjusted r(2) = 0.24) and intraocular pressure change and body mass loss (adjusted r(2) = 0.51). In conclusion, intraocular pressure was progressively reduced during a period of exercise causing dehydration, but remained relatively stable when hydration was maintained. The present study revealed a moderate relationship between dehydration (body mass loss) and intraocular pressure change. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/18295549','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/18295549">Baroreceptors mask sympathetic responses to high intraocular pressure in dogs.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Yahagi, Toru; Koyama, Shozo; Osaka, Kazumasa; Koyama, Haruhide 2008-05-30 These experiments were designed to investigate whether increasing intraocular pressure (IOP) in anesthetized dogs produces differential control of sympathetic nerve activities to various organs (heart, kidney, liver, and spleen) and if these sympathetic responses are modified by baroreceptors. We performed simultaneous multi-recordings of cardiac, renal, hepatic and splenic sympathetic nerve activities (CNA, RNA, HNA and SpNA, respectively) during 2 min of increasing IOP to a mean pressure of 30 mmHg. After increasing IOP in dogs with the intact baroreceptors, all of measured nerve activities did not change significantly throughout the experiment. In dogs with denervation of baroreceptors (cervical vagotomy with denervation of the carotid sinus and aortic nerves), only RNA and CNA showed significant increases in response to the increased IOP. However, time course changes in HNA and SpNA did not show any significant differences as compared with the baseline or that of the control group. These results indicate that systemic sympathetic nerve responses to increasing IOP are masked by systemic baroreceptors. As animals were denervated of their systemic baroreceptors, the unidirectional sympathoexcitatory responses to increased IOP were observed on CNA and RNA, but not on HNA and SpNA. These sympathetic outflow, when systemic baroreceptors are impaired as observed in old age, may play an important role in management of glaucoma attack with the use of adrenolytic drugs. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19860057041&hterms=women&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D70%26Ntt%3Dwomen','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19860057041&hterms=women&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D70%26Ntt%3Dwomen">Cardiovascular responses of women to lower body negative pressure</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Frey, M. A. B.; Mathes, K. L.; Hoffler, G. W. 1986-01-01 The effects of lower body negative pressure (LBNP) on the cardiovascular response of 20 women between 23-43 years are evaluated. Calf circumference and cardiovascular data were recorded for women in the follicular and luteal phases of the menstrual cycle at -30, -40, and -50 mm Hg LBNP. The data reveal that the two menstrual phases did not cause differences in the way women respond to LBNP. It is observed that during LBNP calf circumference is enlarged; transthoracic impedance, and heart rate are increased; stroke volume, left ventricular ejection time, the Heather Index of contractility and systolic pressure, and cardiac output are reduced; and total peripheral resistance is elevated. The experimental data are compared to Montgomery et al. (1979). It is noted that the response of women to -50 mm Hg LBNP is similar to that of men; however, women adapt to stresses on the cardiovascular system with greater heart rate adjustments. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AAS...22934744P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AAS...22934744P">Ram Pressure Stripping: Observations Meet Simulations</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Past, Matthew; Ruszkowski, Mateusz; Sharon, Keren 2017-01-01 Ram pressure stripping occurs when a galaxy falls into the potential well of a cluster, removing gas and dust as the galaxy travels through the intracluster medium. This interaction leads to filamentary gas tails stretching behind the galaxy and plays an important role in galaxy evolution. Previously, these “jellyfish” galaxies had only been observed in nearby clusters, but recently, higher redshift (z > 0.3) examples have been found from HST data imaging.Recent work has shown that cosmic rays injected by supernovae can cause galactic disks to thicken due to cosmic ray pressure. We run three-dimensional magneto-hydrodynamical simulations of ram pressure stripping including cosmic rays to compare to previous models. We study how the efficiency of the ram pressure stripping of the gas, and the morphology of the filamentary tails, depend on the magnitude of the cosmic ray pressure support. We generate mock X-ray images and radio polarization data. Simultaneously, we perform an exhaustive search of the HST archive to increase the sample of jellyfish galaxies and compare selected cases to simulations. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1983BoLMe..27...69G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1983BoLMe..27...69G">Low-level wind response to mesoscale pressure systems</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Garratt, J. R.; Physick, W. L. 1983-09-01 Observations are presented which show a strong correlation between low-level wind behaviour (e.g., rotation near the surface) and the passage of mesoscale pressure systems. The latter are associated with frontal transition zones, are dominated by a pressure-jump line and a mesoscale high pressure area, and produce locally large horizontal pressure gradients. The wind observations are simulated by specifying a time sequence of perturbation pressure gradient and subsequently solving the vertically-integrated momentum equations with appropriate initial conditions. Very good agreement is found between observed and calculated winds; in particular, (i) a 360 ° rotation in wind on passage of the mesoscale high; (ii) wind-shift lines produced dynamically by the pressure-jump line; (iii) rapid linear increase in wind speed on passage of the pressure jump. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/10067788','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/10067788">Job strain, blood pressure and response to uncontrollable stress.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Steptoe, A; Cropley, M; Joekes, K 1999-02-01 The association between cardiovascular disease risk and job strain (high-demand, low-control work) may be mediated by heightened physiological stress responsivity. We hypothesized that high levels of job strain lead to increased cardiovascular responses to uncontrollable but not controllable stressors. Associations between job strain and blood pressure reductions after the working day (unwinding) were also assessed. Assessment of cardiovascular responses to standardized behavioral tasks, and ambulatory monitoring of blood pressure and heart rate during a working day and evening. We studied 162 school teachers (60 men, 102 women) selected from a larger survey as experiencing high or low job strain. Blood pressure, heart rate and electrodermal responses to an externally paced (uncontrollable) task and a self-paced (controllable) task were assessed. Blood pressure was monitored using ambulatory apparatus from 0900 to 2230 h on a working day. The groups of subjects with high and low job strain did not differ in demographic factors, body mass or resting cardiovascular activity. Blood pressure reactions to the uncontrollable task were greater in high than low job-strain groups, but responses to the controllable task were not significantly different between groups. Systolic and diastolic blood pressure did not differ between groups over the working day, but decreased to a greater extent in the evening in subjects with low job strain. Job strain is associated with a heightened blood pressure response to uncontrollable but not controllable tasks. The failure of subjects with high job strain to show reduced blood pressure in the evening may be a manifestation of chronic allostatic load. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23140567','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23140567">Low-pressure pulsed focused ultrasound with microbubbles promotes an anticancer immunological response.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Liu, Hao-Li; Hsieh, Han-Yi; Lu, Li-An; Kang, Chiao-Wen; Wu, Ming-Fang; Lin, Chun-Yen 2012-11-11 High-intensity focused-ultrasound (HIFU) has been successfully employed for thermal ablation of tumors in clinical settings. Continuous- or pulsed-mode HIFU may also induce a host antitumor immune response, mainly through expansion of antigen-presenting cells in response to increased cellular debris and through increased macrophage activation/infiltration. Here we demonstrated that another form of focused ultrasound delivery, using low-pressure, pulsed-mode exposure in the presence of microbubbles (MBs), may also trigger an antitumor immunological response and inhibit tumor growth. A total of 280 tumor-bearing animals were subjected to sonographically-guided FUS. Implanted tumors were exposed to low-pressure FUS (0.6 to 1.4 MPa) with MBs to increase the permeability of tumor microvasculature. Tumor progression was suppressed by both 0.6 and 1.4-MPa MB-enhanced FUS exposures. We observed a transient increase in infiltration of non-T regulatory (non-Treg) tumor infiltrating lymphocytes (TILs) and continual infiltration of CD8+ cytotoxic T-lymphocytes (CTL). The ratio of CD8+/Treg increased significantly and tumor growth was inhibited. Our findings suggest that low-pressure FUS exposure with MBs may constitute a useful tool for triggering an anticancer immune response, for potential cancer immunotherapy. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24098362','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24098362">Weather forecasting by insects: modified sexual behaviour in response to atmospheric pressure changes.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Pellegrino, Ana Cristina; Peñaflor, Maria Fernanda Gomes Villalba; Nardi, Cristiane; Bezner-Kerr, Wayne; Guglielmo, Christopher G; Bento, José Maurício Simões; McNeil, Jeremy N 2013-01-01 Prevailing abiotic conditions may positively or negatively impact insects at both the individual and population levels. For example while moderate rainfall and wind velocity may provide conditions that favour development, as well as movement within and between habitats, high winds and heavy rains can significantly decrease life expectancy. There is some evidence that insects adjust their behaviours associated with flight, mating and foraging in response to changes in barometric pressure. We studied changes in different mating behaviours of three taxonomically unrelated insects, the curcurbit beetle, Diabrotica speciosa (Coleoptera), the true armyworm moth, Pseudaletia unipuncta (Lepidoptera) and the potato aphid, Macrosiphum euphorbiae (Hemiptera), when subjected to natural or experimentally manipulated changes in atmospheric pressure. In response to decreasing barometric pressure, male beetles exhibited decreased locomotory activity in a Y-tube olfactometer with female pheromone extracts. However, when placed in close proximity to females, they exhibited reduced courtship sequences and the precopulatory period. Under the same situations, females of the true armyworm and the potato aphid exhibited significantly reduced calling behaviour. Neither the movement of male beetles nor the calling of armyworm females differed between stable and increasing atmospheric pressure conditions. However, in the case of the armyworm there was a significant decrease in the incidence of mating under rising atmospheric conditions, suggesting an effect on male behaviour. When atmospheric pressure rose, very few M. euphorbiae oviparae called. This was similar to the situation observed under decreasing conditions, and consequently very little mating was observed in this species except under stable conditions. All species exhibited behavioural modifications, but there were interspecific differences related to size-related flight ability and the diel periodicity of mating activity. We </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25781166','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25781166">Quantifying patterns of change in marine ecosystem response to multiple pressures.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Large, Scott I; Fay, Gavin; Friedland, Kevin D; Link, Jason S 2015-01-01 The ability to understand and ultimately predict ecosystem response to multiple pressures is paramount to successfully implement ecosystem-based management. Thresholds shifts and nonlinear patterns in ecosystem responses can be used to determine reference points that identify levels of a pressure that may drastically alter ecosystem status, which can inform management action. However, quantifying ecosystem reference points has proven elusive due in large part to the multi-dimensional nature of both ecosystem pressures and ecosystem responses. We used ecological indicators, synthetic measures of ecosystem status and functioning, to enumerate important ecosystem attributes and to reduce the complexity of the Northeast Shelf Large Marine Ecosystem (NES LME). Random forests were used to quantify the importance of four environmental and four anthropogenic pressure variables to the value of ecological indicators, and to quantify shifts in aggregate ecological indicator response along pressure gradients. Anthropogenic pressure variables were critical defining features and were able to predict an average of 8-13% (up to 25-66% for individual ecological indicators) of the variation in ecological indicator values, whereas environmental pressures were able to predict an average of 1-5 % (up to 9-26% for individual ecological indicators) of ecological indicator variation. Each pressure variable predicted a different suite of ecological indicator's variation and the shapes of ecological indicator responses along pressure gradients were generally nonlinear. Threshold shifts in ecosystem response to exploitation, the most important pressure variable, occurred when commercial landings were 20 and 60% of total surveyed biomass. Although present, threshold shifts in ecosystem response to environmental pressures were much less important, which suggests that anthropogenic pressures have significantly altered the ecosystem structure and functioning of the NES LME. Gradient response </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/17552684','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/17552684">Liquid jet response to internal modulated ultrasonic radiation pressure and stimulated drop production.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Lonzaga, Joel B; Osterhoudt, Curtis F; Thiessen, David B; Marston, Philip L 2007-06-01 Experimental evidence shows that a liquid jet in air is an acoustic waveguide having a cutoff frequency inversely proportional to the jet diameter. Ultrasound applied to the jet supply liquid can propagate within the jet when the acoustic frequency is near to or above the cutoff frequency. Modulated radiation pressure is used to stimulate large amplitude deformations and the breakup of the jet into drops. The jet response to the modulated internal ultrasonic radiation pressure was monitored along the jet using (a) an optical extinction method and (b) images captured by a video camera. The jet profile oscillates at the frequency of the radiation pressure modulation and where the response is small, the amplitude was found to increase in proportion to the square of the acoustic pressure amplitude as previously demonstrated for oscillating drops [P.L. Marston and R.E. Apfel, J. Acoust. Soc. Am. 67, 27-37 (1980)]. Small amplitude deformations initially grow approximately exponentially with axial distance along the jet. Though aspects of the perturbation growth can be approximated from Rayleigh's analysis of the capillary instability, some detailed features of the observed jet response to modulated ultrasound are unexplained neglecting the effects of gravity. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20020039729&hterms=hemoglobin&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D50%26Ntt%3Dhemoglobin','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20020039729&hterms=hemoglobin&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D50%26Ntt%3Dhemoglobin">Cerebrovascular Responses During Lower Body Negative Pressure-Induced Presyncope</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Kuriyama, Kana; Watenpaugh, D. E.; Hargens, Alan R.; Ueno, T.; Ballard, R. E.; Fortney, S. M. 1996-01-01 Reduced orthostatic tolerance is commonly observed after space flight, occasionally causing presyncopal conditions. Although the cerebrovascular system may play an important role in presyncope, there have been few reports concerning cerebral hemodynamics during presyncope. The purpose of this study was to investigate cerebrovascular responses during presyncope induced by lower body negative pressure (LBNP). Seven healthy male volunteers were exposed to LBNP in steps of -10 mmHg every 3 min until presyncopal symptoms were detected. Blood pressure (BP) and heart rate (HR) were measured with a finger cuff. Cerebral tissue oxy- and deoxy- hemoglobin (Hb) concentrations were estimated using near infrared spectroscopy (NIRS). Cerebral blood flow (CBF) velocity at the middle cerebral artery was measured with Transcranial Doppler Sonography (TCD). We focused on the data during the 2 min before endpoint. BP marked a gradual decrease (91 to 86 mmHg from 2 min to 30 sec before endpoint), which was accelerated along with HR decrease during the final 30 sec (86 to 71 mmHg). Cerebral oxy-Hb concentration decreases as presyncope is approached while total-Hb concentration remains fairly constant. TCD reveals a decrease in the CBF velocity. The TCD and NIRS results suggest that CBF decreases along with the BP decrease. Cerebrovascular responses during presyncope are closely related to cardiovascular responses. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3752735','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3752735">Pressure-specific and multiple pressure response of fish assemblages in European running waters☆</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Schinegger, Rafaela; Trautwein, Clemens; Schmutz, Stefan 2013-01-01 We classified homogenous river types across Europe and searched for fish metrics qualified to show responses to specific pressures (hydromorphological pressures or water quality pressures) vs. multiple pressures in these river types. We analysed fish taxa lists from 3105 sites in 16 ecoregions and 14 countries. Sites were pre-classified for 15 selected pressures to separate unimpacted from impacted sites. Hierarchical cluster analysis was used to split unimpacted sites into four homogenous river types based on species composition and geographical location. Classification trees were employed to predict associated river types for impacted sites with four environmental variables. We defined a set of 129 candidate fish metrics to select the best reacting metrics for each river type. The candidate metrics represented tolerances/intolerances of species associated with six metric types: habitat, migration, water quality sensitivity, reproduction, trophic level and biodiversity. The results showed that 17 uncorrelated metrics reacted to pressures in the four river types. Metrics responded specifically to water quality pressures and hydromorphological pressures in three river types and to multiple pressures in all river types. Four metrics associated with water quality sensitivity showed a significant reaction in up to three river types, whereas 13 metrics were specific to individual river types. Our results contribute to the better understanding of fish assemblage response to human pressures at a pan-European scale. The results are especially important for European river management and restoration, as it is necessary to uncover underlying processes and effects of human pressures on aquatic communities. PMID:24003262 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/8226001','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/8226001">Blood pressure reactivity in the evaluation of resting blood pressure and mood responses to pindolol and propranolol in hypertensive patients.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Potempa, K M; Fogg, L F; Fish, A F; Kravitz, H M 1993-01-01 The purpose of this exploratory study was to evaluate the relationship of blood pressure reactivity during exercise to treatment responsiveness to two commonly used beta-adrenergic blocking agents, propranolol and pindolol. Prospective, placebo-controlled, balanced, cross-over clinical trial. University-affiliated medical center. A convenience sample of 19 white male subjects with mild to moderate essential hypertension were studied. The mean age was 63.4 years (SD = 5.2). The mean resting systolic blood pressure (SBP) was 158.6 mm Hg (SD = 12.3) and mean resting diastolic blood pressure (DBP) was 96.4 mm Hg (SD = 8.6). They had no clinical evidence of secondary hypertension, diabetes, heart, liver, pulmonary, or renal disease. Resting blood pressure; blood pressure reactivity to exercise; self-report measures of depressive symptoms, and mood disturbances. Antihypertensive medication was tapered off and subjects were free of all prescription drugs for 2 weeks. Subjects were randomly assigned to propranolol-pindolol or pindolol-propranolol group. Each 4- to 6-week treatment phase was preceded by a 2-week placebo phase. At the end of the initial placebo phase and each active drug treatment phase, subjects were assessed for depression and mood disturbances by use of standardized measures and were given a graded exercise test on a cycle ergometer. Resting blood pressure was assessed weekly and before each exercise test. Significant relationships between DBP reactivity to exercise during the placebo phase and the degree of blood pressure and mood responsiveness to pindolol and propranolol treatment were observed. Subjects demonstrating high DBP reactivity required high doses of beta-blocker for resting DBP reduction, and these subjects showed the least change in mood at high doses. Similar patterns were found for the relationship of SBP reactivity and blood pressure and mood responsiveness to drug treatment, but these relationships were not statistically significant </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/9674646','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/9674646">Prenatal malnutrition-induced changes in blood pressure: dissociation of stress and nonstress responses using radiotelemetry.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Tonkiss, J; Trzcińska, M; Galler, J R; Ruiz-Opazo, N; Herrera, V L 1998-07-01 A link between prenatal malnutrition and hypertension in human populations has recently been proposed. Rat models of prenatal malnutrition have provided major support for this theory on the basis of tail-cuff measurements. However, this technique requires restraint and elevated temperature, both potential sources of stress. To determine the effect of prenatal protein malnutrition on blood pressure under nonstress conditions, 24-hour radiotelemetric measurements were taken in the home cage. Male rats born to dams fed a 6% casein diet for 5 weeks before mating and throughout pregnancy were studied in early adulthood (from 96 days of age). During the waking phase of their cycle but not the sleep phase, prenatal malnutrition gave rise to small but significant elevations of diastolic blood pressure and heart rate compared with well-nourished controls. Direct effects of stress on blood pressure responses were determined in a second experiment using an olfactory stressor. Prenatally malnourished rats showed a greater increase in both systolic and diastolic pressures compared with well-nourished controls during the first exposure to ammonia. A different pattern of change of cardiovascular responses was also observed during subsequent presentations of the stressor. These findings of a small baseline increase in diastolic pressure consequent to prenatal malnutrition, but an augmented elevation of both systolic and diastolic pressures after first exposure to stress, suggest the need to reevaluate interpretation of the large elevations in blood pressure previously observed in malnourished animals using the stressful tail-cuff procedure. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015APS..DPPBI2005L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015APS..DPPBI2005L">Observation, Identification, and Impact of Multi-Modal Plasma Responses to Applied Magnetic Perturbations</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Logan, Nikolas 2015-11-01 Experiments on DIII-D have demonstrated that multiple kink modes with comparable amplitudes can be driven by applied nonaxisymmetric fields with toroidal mode number n=2, in good agreement with ideal MHD models. In contrast to a single-mode model, the structure of the response measured using poloidally distributed magnetic sensors changes when varying the applied poloidal spectrum. This is most readily evident in that different spectra of applied fields can independently excite inboard and outboard magnetic responses, which are identified as distinct plasma modes by IPEC modeling. The outboard magnetic response is correlated with the plasma pressure and consistent with the long wavelength perturbations of the least stable, pressure driven kinks calculated by DCON and used in IPEC. The models show the structure of the pressure driven modes extends throughout the bad curvature region and into the plasma core. The inboard plasma response is correlated with the edge current profile and requires the inclusion of multiple kink modes with greater stability, including opposite helicity modes, to replicate the experimental observations in the models. IPEC reveals the resulting mode structure to be highly localized in the plasma edge. Scans of the applied spectrum show this response induces the transport that influences the density pump-out, as well as the toroidal rotation drag observed in experiment and modeled using PENT. The classification of these two mode types establishes a new multi-modal paradigm for n=2 plasma response and guides the understanding needed to optimize 3D fields for independent control of stability and transport. Supported by US DOE contract DE-AC02-09CH11466. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20100010990','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20100010990">Nanorod-Based Fast-Response Pressure-Sensitive Paints</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Bencic, Timothy; VanderWal, Randall 2007-01-01 A proposed program of research and development would be devoted to exploitation of nanomaterials in pressuresensitive paints (PSPs), which are used on wind-tunnel models for mapping surface pressures associated with flow fields. Heretofore, some success has been achieved in measuring steady-state pressures by use of PSPs, but success in measuring temporally varying pressures has been elusive because of the inherent slowness of the optical responses of these materials. A PSP contains a dye that luminesces in a suitable wavelength range in response to photoexcitation in a shorter wavelength range. The luminescence is quenched by oxygen at a rate proportional to the partial pressure of oxygen and thus proportional to the pressure of air. As a result, the intensity of luminescence varies inversely with the pressure of air. The major problem in developing a PSP that could be easily applied to a wind-tunnel model and could be useful for measuring rapidly varying pressure is to provide very high gas diffusivity for rapid, easy transport of oxygen to and from active dye molecules. Most PSPs include polymer-base binders, which limit the penetration of oxygen to dye molecules, thereby reducing responses to pressure fluctuations. The proposed incorporation of nanomaterials (somewhat more specifically, nanorods) would result in paints having nanostructured surfaces that, relative to conventional PSP surfaces, would afford easier and more nearly complete access of oxygen molecules to dye molecules. One measure of greater access is effective surface area: For a typical PSP as proposed applied to a given solid surface, the nanometer-scale structural features would result in an exposed surface area more than 100 times that of a conventional PSP, and the mass of proposed PSP needed to cover the surface would be less than tenth of the mass of the conventional PSP. One aspect of the proposed development would be to synthesize nanorods of Si/SiO2, in both tangle-mat and regular- array </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5341703','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5341703">Intrathecal fentanyl abolishes the exaggerated blood pressure response to cycling in hypertensive men</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Barbosa, Thales C.; Vianna, Lauro C.; Fernandes, Igor A.; Prodel, Eliza; Rocha, Helena N. M.; Garcia, Vinicius P.; Rocha, Natalia G.; Secher, Niels H. 2016-01-01 Key points The increase in blood pressure observed during physical activities is exaggerated in patients with hypertension, exposing them to a higher cardiovascular risk.Neural signals from the skeletal muscles appear to be overactive, resulting in this abnormal response in hypertensive patients.In the present study, we tested whether the attenuation of these neural signals in hypertensive patients could normalize their abnormal increase in blood pressure during physical activity.Attenuation of the neural signals from the leg muscles with intrathecal fentanyl injection reduced the blood pressure of hypertensive men during cycling exercise to a level comparable to that of normotensive men.Skeletal muscle afferent overactivity causes the abnormal cardiovascular response to exercise and was reverted in this experimental model, appearing as potential target for treatment. Abstract Hypertensive patients present an exaggerated increase in blood pressure and an elevated cardiovascular risk during exercise. Although controversial, human studies suggest that group III and IV skeletal muscle afferents might contribute to this abnormal response. In the present study, we investigated whether attenuation of the group III and IV muscle afferent signal of hypertensive men eliminates the exaggerated increase in blood pressure occurring during exercise. Eight hypertensive men performed two sessions of 5 min of cycling exercise at 40 W. Between sessions, the subjects were provided with a lumbar intrathecal injection of fentanyl, a μ‐opioid receptor agonist, aiming to attenuate the central projection of opioid‐sensitive group III and IV muscle afferent nerves. The cardiovascular response to exercise of these subjects was compared with that of six normotensive men. During cycling, the hypertensive group demonstrated an exaggerated increase in blood pressure compared to the normotensive group (mean ± SEM: +17 ± 3 vs. +8 ± 1 mmHg, respectively; P < 0.05), whereas the </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3530365','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3530365">Genome-wide Linkage and Positional Association Study of Blood Pressure Response to Dietary Sodium Intervention</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Mei, Hao; Gu, Dongfeng; Hixson, James E.; Rice, Treva K.; Chen, Jing; Shimmin, Lawrence C.; Schwander, Karen; Kelly, Tanika N.; Liu, De-Pei; Chen, Shufeng; Huang, Jian-feng; Jaquish, Cashell E.; Rao, Dabeeru C.; He, Jiang 2012-01-01 The authors conducted a genome-wide linkage scan and positional association analysis to identify the genetic determinants of salt sensitivity of blood pressure (BP) in a large family-based, dietary-feeding study. The dietary intervention was conducted among 1,906 participants in rural China (2003–2005). A 7-day low-sodium intervention was followed by a 7-day high-sodium intervention. Salt sensitivity was defined as BP responses to low- and high-sodium interventions. Signals of the logarithm of the odds to the base 10 (LOD ≥ 3) were detected at 33–42 centimorgans of chromosome 2 (2p24.3-2p24.1), with a maximum LOD score of 3.33 for diastolic blood pressure responses to high-sodium intervention. LOD scores were 2.35–2.91 for mean arterial pressure (MAP) and 0.80–1.49 for systolic blood pressure responses in this region, respectively. Correcting for multiple tests, single nucleotide polymorphism (SNP) rs11674786 (2.7 kilobases upstream of the family with sequence similarity 84, member A, gene (FAM84A)) in the linkage region was significantly associated with diastolic blood pressure (P = 0.0007) and MAP responses (P = 0.0007), and SNP rs16983422 (2.8 kilobases upstream of the visinin-like 1 gene (VSNL1)) was marginally associated with diastolic blood pressure (P = 0.005) and MAP responses (P = 0.005). An additive interaction between SNPs rs11674786 and rs16983422 was observed, with P = 7.00 × 10−5 and P = 7.23 × 10−5 for diastolic blood pressure and MAP responses, respectively. The authors concluded that genetic region 2p24.3-2p24.1 might harbor functional variants for the salt sensitivity of BP. PMID:22865701 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/8214132','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/8214132">Postural vascular response in human skin: passive and active reactions to alteration of transmural pressure.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Jepsen, H; Gaehtgens, P 1993-09-01 Laser-Doppler (LD) fluxmetry was performed in the palmar finger skin of healthy subjects to study the mechanisms contributing to the postural vascular response. Local transmural pressure in the skin blood vessels of the region studied was altered for 1 min in two experimental series either by passive movement of the arm to different vertical hand positions relative to heart level or by application of external pressure (-120-180 mmHg) to the finger. Heart and respiratory rate, arterial blood pressure, and LD flux in the contralateral finger (kept at heart level) were measured. The measurements suggest a compound reaction of local (myogenic) and systemic (neurogenic) mechanisms: the local regulatory component appears as a graded active vascular response elicited by passive vessel distension or compression. A systemic component, associated with a single deep inspiration, is frequently observed during the actual movement of the arm. In addition, prolonged holding of the test hand in a given vertical position also elicits a delayed vascular response in the control hand at heart level, which may be generated by volume receptors in the intrathoracic low-pressure system. </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_1");'>1</a></li> <li class="active">2</li> <li><a href="#" onclick='return showDiv("page_3");'>3</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_3" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_1");'>1</a></li> <li><a href="#" onclick='return showDiv("page_2");'>2</a></li> <li class="active">3</li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="41"> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29648803','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29648803">Flexible Ferroelectric Sensors with Ultrahigh Pressure Sensitivity and Linear Response over Exceptionally Broad Pressure Range.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Lee, Youngoh; Park, Jonghwa; Cho, Soowon; Shin, Young-Eun; Lee, Hochan; Kim, Jinyoung; Myoung, Jinyoung; Cho, Seungse; Kang, Saewon; Baig, Chunggi; Ko, Hyunhyub 2018-04-24 Flexible pressure sensors with a high sensitivity over a broad linear range can simplify wearable sensing systems without additional signal processing for the linear output, enabling device miniaturization and low power consumption. Here, we demonstrate a flexible ferroelectric sensor with ultrahigh pressure sensitivity and linear response over an exceptionally broad pressure range based on the material and structural design of ferroelectric composites with a multilayer interlocked microdome geometry. Due to the stress concentration between interlocked microdome arrays and increased contact area in the multilayer design, the flexible ferroelectric sensors could perceive static/dynamic pressure with high sensitivity (47.7 kPa -1 , 1.3 Pa minimum detection). In addition, efficient stress distribution between stacked multilayers enables linear sensing over exceptionally broad pressure range (0.0013-353 kPa) with fast response time (20 ms) and high reliability over 5000 repetitive cycles even at an extremely high pressure of 272 kPa. Our sensor can be used to monitor diverse stimuli from a low to a high pressure range including weak gas flow, acoustic sound, wrist pulse pressure, respiration, and foot pressure with a single device. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2270201','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2270201">Responses of aortic depressor nerve-evoked neurones in rat nucleus of the solitary tract to changes in blood pressure</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Zhang, Jing; Mifflin, Steven W 2000-01-01 Using electrophysiological techniques, the discharge of neurones in the nucleus of the solitary tract (NTS) receiving aortic depressor nerve (ADN) inputs was examined during blood pressure changes induced by I.V. phenylephrine or nitroprusside in anaesthetized, paralysed and artificially ventilated rats. Various changes in discharge rate were observed during phenylephrine-induced blood pressure elevations: an increase (n = 38), a decrease (n = 5), an increase followed by a decrease (n = 4) and no response (n = 11). In cells receiving a monosynaptic ADN input (MSNs), the peak discharge frequency response was correlated to the rate of increase in mean arterial pressure (P < 0.01) but was not correlated to the absolute increase in blood pressure. The peak discharge frequency response of cells receiving a polysynaptic ADN input (PSNs) was correlated to neither the absolute increase in blood pressure nor the rate of increase in mean arterial pressure. Diverse changes in discharge rate were observed during nitroprusside-induced reductions in blood pressure: an increase (n = 3), a decrease (n = 10), an increase followed by a decrease (n = 3) and no response (n = 6). Reductions in pressure of 64 ± 2 mmHg produced weak reductions in spontaneous discharge of 1.3 ± 0.9 Hz and only totally abolished spontaneous discharge in one neurone. These response patterns of NTS neurones during changes in arterial pressure suggest that baroreceptor inputs are integrated differently in MSNs compared to PSNs. The sensitivity of MSNs to the rate of change of pressure provides a mechanism for the rapid regulation of cardiovascular function. The lack of sensitivity to the mean level of a pressure increase in both MSNs and PSNs suggests that steady-state changes in pressure are encoded by the number of active neurones and not graded changes in the discharge of individual neurones. Both MSNs and PSNs receive tonic excitatory inputs from the arterial baroreceptors; however, these tonic inputs </li> <li> <a target="_blank" onclick="trackOutboundLink('https://rosap.ntl.bts.gov/view/dot/5197','DOTNTL'); return false;" href="https://rosap.ntl.bts.gov/view/dot/5197">Tire pressure special study : vehicle observation data</a> <a target="_blank" href="http://ntlsearch.bts.gov/tris/index.do">DOT National Transportation Integrated Search</a> 2001-08-01 Twenty seven percent of passenger cars with : regular passenger car tires have at least one : tire that is underinflated by 8 psi or more. : Tire Pressure Special Study: Vehicle : Observation Data is the third in a series of : research notes co... </li> <li> <a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19980022437','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19980022437">Frequency Response of Pressure Sensitive Paints</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Winslow, Neal A.; Carroll, Bruce F.; Setzer, Fred M. 1996-01-01 An experimental method for measuring the frequency response of Pressure Sensitive Paints (PSP) is presented. These results lead to the development of a dynamic correction technique for PSP measurements which is of great importance to the advancement of PSP as a measurement technique. The ability to design such a dynamic corrector is most easily formed from the frequency response of the given system. An example of this correction technique is shown. In addition to the experimental data, an analytical model for the frequency response is developed from the one dimensional mass diffusion equation. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27793545','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27793545">Chronic binge alcohol consumption during pregnancy alters rat maternal uterine artery pressure response.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Naik, Vishal D; Lunde-Young, Emilie R; Davis-Anderson, Katie L; Orzabal, Marcus; Ivanov, Ivan; Ramadoss, Jayanth 2016-11-01 We aimed to investigate pressure-dependent maternal uterine artery responses and vessel remodeling following gestational binge alcohol exposure. Two groups of pregnant rats were used: the alcohol group (28.5% wt/v, 6.0 g/kg, once-daily orogastric gavage in a binge paradigm between gestational day (GD) 5-19) and pair-fed controls (isocalorically matched). On GD20, excised, pressurized primary uterine arteries were studied following equilibration (60 mm Hg) using dual chamber arteriograph. The uterine artery diameter stabilized at 20 mm Hg, showed passive distension at 40 mm Hg, and redeveloped tone at 60 mm Hg. An alcohol effect (P = 0.0025) was observed on the percent constriction of vessel diameter with greater pressure-dependent myogenic constriction. Similar alcohol effect was noted with lumen diameter response (P = 0.0020). The percent change in media:lumen ratio was higher in the alcohol group (P < 0.0001). Thus, gestational alcohol affects pressure-induced uterine artery reactivity, inward-hypotrophic remodeling, and adaptations critical for nutrient delivery to the fetus. Copyright © 2016 Elsevier Inc. All rights reserved. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/12091756','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/12091756">Genetics and blood pressure response to exercise, and its interactions with adiposity.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Rankinen, T; Bouchard, C 2002-01-01 Regular aerobic exercise has the potential to induce several beneficial health effects, including a decrease in blood pressure level, especially in hypertensive patients and in subjects with high-normal blood pressure. However, it is also well documented that some people show more pronounced blood pressure responses to endurance training than others, despite identical training programs and similar initial blood pressure levels. This kind of variation is an example of normal biologic diversity and most likely originates from interactions with genetic factors. Data from genetic epidemiologic studies indicate that there is a genetic component that affects both resting blood pressure and blood pressure responses to acute exercise. Evidence from molecular genetic studies is scarce, but the first reports suggest that DNA sequence variation in the hypertension candidate genes, such as angiotensinogen, also modify blood pressure responses to endurance training. The current knowledge regarding the role of genetic factors in the modification of blood pressure responses to endurance training will be summarized and discussed. Copyright 2002 CHF, Inc. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4257587','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4257587">On the Pressure Response in the Brain due to Short Duration Blunt Impacts</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Pearce, Christopher W.; Young, Philippe G. 2014-01-01 When the head is subject to non-penetrating (blunt) impact, contusion-type injuries are commonly identified beneath the impact site (the coup) and, in some instances, at the opposite pole (the contre-coup). This pattern of injury has long eluded satisfactory explanation and blunt head injury mechanisms in general remain poorly understood. There are only a small number of studies in the open literature investigating the head's response to short duration impacts, which can occur in collisions with light projectiles. As such, the head impact literature to date has focussed almost exclusively on impact scenarios which lead to a quasi-static pressure response in the brain. In order to investigate the response of the head to a wide range of impact durations, parametric numerical studies were performed on a highly bio-fidelic finite element model of the human head created from in vivo magnetic resonance imaging (MRI) scan data with non-linear tissue material properties. We demonstrate that short duration head impacts can lead to potentially deleterious transients of positive and negative intra-cranial pressure over an order of magnitude larger than those observed in the quasi-static regime despite reduced impact force and energy. The onset of this phenomenon is shown to be effectively predicted by the ratio of impact duration to the period of oscillation of the first ovalling mode of the system. These findings point to dramatically different pressure distributions in the brain and hence different patterns of injury depending on projectile mass, and provide a potential explanation for dual coup/contre-coup injuries observed clinically. PMID:25478695 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25478695','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25478695">On the pressure response in the brain due to short duration blunt impacts.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Pearce, Christopher W; Young, Philippe G 2014-01-01 When the head is subject to non-penetrating (blunt) impact, contusion-type injuries are commonly identified beneath the impact site (the coup) and, in some instances, at the opposite pole (the contre-coup). This pattern of injury has long eluded satisfactory explanation and blunt head injury mechanisms in general remain poorly understood. There are only a small number of studies in the open literature investigating the head's response to short duration impacts, which can occur in collisions with light projectiles. As such, the head impact literature to date has focussed almost exclusively on impact scenarios which lead to a quasi-static pressure response in the brain. In order to investigate the response of the head to a wide range of impact durations, parametric numerical studies were performed on a highly bio-fidelic finite element model of the human head created from in vivo magnetic resonance imaging (MRI) scan data with non-linear tissue material properties. We demonstrate that short duration head impacts can lead to potentially deleterious transients of positive and negative intra-cranial pressure over an order of magnitude larger than those observed in the quasi-static regime despite reduced impact force and energy. The onset of this phenomenon is shown to be effectively predicted by the ratio of impact duration to the period of oscillation of the first ovalling mode of the system. These findings point to dramatically different pressure distributions in the brain and hence different patterns of injury depending on projectile mass, and provide a potential explanation for dual coup/contre-coup injuries observed clinically. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26113143','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26113143">Characterising multi-level effects of acute pressure exposure on a shallow-water invertebrate: insights into the kinetics and hierarchy of the stress response.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Morris, James P; Thatje, Sven; Ravaux, Juliette; Shillito, Bruce; Hauton, Chris 2015-08-01 Hydrostatic pressure is an important, ubiquitous, environmental variable of particular relevance in the marine environment. However, it is widely overlooked despite recent evidence that some marine ectotherms may be demonstrating climate-driven bathymetric range shifts. Wide-ranging effects of increased hydrostatic pressure have been observed from the molecular through to the behavioural level. Still, no study has simultaneously examined these multiple levels of organisation in a single experiment in order to understand the kinetics, hierarchy and interconnected nature of such responses during an acute exposure, and over a subsequent recovery period. Here, we quantify the transcription of a set of previously characterised genes during and after acute pressure exposure in adults of the shrimp Palaemonetes varians. Further, we perform respiratory rate and behavioural analysis over the same period. Increases in expression of genes associated with stress and metabolism were observed during and after high-pressure exposure. Respiratory rate increased during exposure and into the recovery period. Finally, differential behaviour was observed under elevated hydrostatic pressure in comparison to ambient pressure. Characterising generalised responses to acute elevated pressure is a vital precursor to longer-term, acclimation-based pressure studies. Results provide a novel insight into what we term the overall stress response (OSR) to elevated pressure; a concept that we suggest to be applicable to other environmental stressors. We highlight the importance of considering more than a single component of the stress response in physiological studies, particularly in an era where environmental multi-stressor studies are proliferating. © 2015. Published by The Company of Biologists Ltd. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20040088351&hterms=anticipation&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D70%26Ntt%3Danticipation','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20040088351&hterms=anticipation&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D70%26Ntt%3Danticipation">Plant adaptation to low atmospheric pressures: potential molecular responses</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Ferl, Robert J.; Schuerger, Andrew C.; Paul, Anna-Lisa; Gurley, William B.; Corey, Kenneth; Bucklin, Ray 2002-01-01 There is an increasing realization that it may be impossible to attain Earth normal atmospheric pressures in orbital, lunar, or Martian greenhouses, simply because the construction materials do not exist to meet the extraordinary constraints imposed by balancing high engineering requirements against high lift costs. This equation essentially dictates that NASA have in place the capability to grow plants at reduced atmospheric pressure. Yet current understanding of plant growth at low pressures is limited to just a few experiments and relatively rudimentary assessments of plant vigor and growth. The tools now exist, however, to make rapid progress toward understanding the fundamental nature of plant responses and adaptations to low pressures, and to develop strategies for mitigating detrimental effects by engineering the growth conditions or by engineering the plants themselves. The genomes of rice and the model plant Arabidopsis thaliana have recently been sequenced in their entirety, and public sector and commercial DNA chips are becoming available such that thousands of genes can be assayed at once. A fundamental understanding of plant responses and adaptation to low pressures can now be approached and translated into procedures and engineering considerations to enhance plant growth at low atmospheric pressures. In anticipation of such studies, we present here the background arguments supporting these contentions, as well as informed speculation about the kinds of molecular physiological responses that might be expected of plants in low-pressure environments. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017MS%26E..249a2003P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017MS%26E..249a2003P">Pressure Response of Various Gases in a Pneumatic Resistance Capacitance System and Pipe</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Peng, J.; Youn, C.; Tadano, K.; Kagawa, T. 2017-10-01 City gas, such as propane and methane, is widely used as a fuel in households and factories. Recently, hydrogen as a clean and efficient fuel has been proposed for fuel cell vehicles. However, few studies have investigated pressure control and response of gases considering their properties. This study investigated the static flow rate characteristics in an orifice with four gases—air, propane, methane, and hydrogen. Then, a pressure response experiment was performed using a pneumatic resistance capacitance system comprising an isothermal chamber and a nozzle flapper, and the time constant of the pressure response with various gases was analysed with a mathematical model. The simulation results agreed with the experimental data. Finally, the differences in pressure propagation in a pipe with various gases were explicated by a pressure response experiment. The results showed that the pressure response speed of hydrogen is faster than that of the other three gases because of its small molecular weight. Therefore, the pressure control equipment of hydrogen needs a high response speed. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22356881','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22356881">The effects of stereotypes and observer pressure on athletic performance.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Krendl, Anne; Gainsburg, Izzy; Ambady, Nalini 2012-02-01 Although the effects of negative stereotypes and observer pressure on athletic performance have been well researched, the effects of positive stereotypes on performance, particularly in the presence of observers, is not known. In the current study, White males watched a video either depicting Whites basketball players as the best free throwers in the NBA (positive stereotype), Black basketball players as the best free throwers in the NBA (negative stereotype), or a neutral sports video (control). Participants then shot a set of free throws, during which half the participants were also videotaped (observer condition), whereas the other half were not (no observer condition). Results demonstrated that positive stereotypes improved free throw performance, but only in the no observer condition. Interestingly, observer pressure interacted with the positive stereotype to lead to performance decrements. In the negative stereotype condition, performance decrements were observed both in the observer and no observer conditions. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1261304-structural-response-gadolinium-phosphate-pressure','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1261304-structural-response-gadolinium-phosphate-pressure">The structural response of gadolinium phosphate to pressure</a> <a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a> Heffernan, Karina M.; Ross, Nancy L.; Spencer, Elinor C.; ... 2016-06-16 In this study, accurate elastic constants for gadolinium phosphate (GdPO 4) have been measured by single-crystal high-pressure diffraction methods. The bulk modulus of GdPO 4 determined under hydrostatic conditions, 128.1(8) GPa (K'=5.8(2)), is markedly different from that obtained with GdPO 4 under non-hydrostatic conditions (160(2) GPa), which indicates the importance of shear stresses on the elastic response of this phosphate. Finally, high pressure Raman and diffraction analysis indicate that the PO 4 tetrahedra behave as rigid units in response to pressure and that contraction of the GdPO 4 structure is facilitated by bending/twisting of the Gd–O–P links that result inmore » increased distortion in the GdO 9 polyhedra.« less </li> <li> <a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19730019023','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19730019023">The analysis of the transient pressure response of the shuttle EPS-ECS cryogenic tanks with external pressurization systems</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Barton, J. E.; Patterson, H. W. 1973-01-01 An analysis of transient pressures in externally pressurized cryogenic hydrogen and oxygen tanks was conducted and the effects of design variables on pressure response determined. The analysis was conducted with a computer program which solves the compressible viscous flow equations in two-dimensional regions representing the tank and external loop. The external loop volume, thermal mass, and heat leak were the dominant design variables affecting the system pressure response. No significant temperature stratification occurred in the fluid contained in the tank. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20160012548','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20160012548">Wavenumber-frequency Spectra of Pressure Fluctuations Measured via Fast Response Pressure Sensitive Paint</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Panda, J.; Roozeboom, N. H.; Ross, J. C. 2016-01-01 The recent advancement in fast-response Pressure-Sensitive Paint (PSP) allows time-resolved measurements of unsteady pressure fluctuations from a dense grid of spatial points on a wind tunnel model. This capability allows for direct calculations of the wavenumber-frequency (k-?) spectrum of pressure fluctuations. Such data, useful for the vibro-acoustics analysis of aerospace vehicles, are difficult to obtain otherwise. For the present work, time histories of pressure fluctuations on a flat plate subjected to vortex shedding from a rectangular bluff-body were measured using PSP. The light intensity levels in the photographic images were then converted to instantaneous pressure histories by applying calibration constants, which were calculated from a few dynamic pressure sensors placed at selective points on the plate. Fourier transform of the time-histories from a large number of spatial points provided k-? spectra for pressure fluctuations. The data provides first glimpse into the possibility of creating detailed forcing functions for vibro-acoustics analysis of aerospace vehicles, albeit for a limited frequency range. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19950049111&hterms=atmospheric+pressure&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D50%26Ntt%3Datmospheric%2Bpressure','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19950049111&hterms=atmospheric+pressure&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D50%26Ntt%3Datmospheric%2Bpressure">Determining the response of sea level to atmospheric pressure forcing using TOPEX/POSEIDON data</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Fu, Lee-Lueng; Pihos, Greg 1994-01-01 The static response of sea level to the forcing of atmospheric pressure, the so-called inverted barometer (IB) effect, is investigated using TOPEX/POSEIDON data. This response, characterized by the rise and fall of sea level to compensate for the change of atmospheric pressure at a rate of -1 cm/mbar, is not associated with any ocean currents and hence is normally treated as an error to be removed from sea level observation. Linear regression and spectral transfer function analyses are applied to sea level and pressure to examine the validity of the IB effect. In regions outside the tropics, the regression coefficient is found to be consistently close to the theoretical value except for the regions of western boundary currents, where the mesoscale variability interferes with the IB effect. The spectral transfer function shows near IB response at periods of 30 degrees is -0.84 +/- 0.29 cm/mbar (1 standard deviation). The deviation from = 1 cm /mbar is shown to be caused primarily by the effect of wind forcing on sea level, based on multivariate linear regression model involving both pressure and wind forcing. The regression coefficient for pressure resulting from the multivariate analysis is -0.96 +/- 0.32 cm/mbar. In the tropics the multivariate analysis fails because sea level in the tropics is primarily responding to remote wind forcing. However, after removing from the data the wind-forced sea level estimated by a dynamic model of the tropical Pacific, the pressure regression coefficient improves from -1.22 +/- 0.69 cm/mbar to -0.99 +/- 0.46 cm/mbar, clearly revealing an IB response. The result of the study suggests that with a proper removal of the effect of wind forcing the IB effect is valid in most of the open ocean at periods longer than 20 days and spatial scales larger than 500 km. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26193779','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26193779">Patient-ventilator asynchrony affects pulse pressure variation prediction of fluid responsiveness.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Messina, Antonio; Colombo, Davide; Cammarota, Gianmaria; De Lucia, Marta; Cecconi, Maurizio; Antonelli, Massimo; Corte, Francesco Della; Navalesi, Paolo 2015-10-01 During partial ventilatory support, pulse pressure variation (PPV) fails to adequately predict fluid responsiveness. This prospective study aims to investigate whether patient-ventilator asynchrony affects PPV prediction of fluid responsiveness during pressure support ventilation (PSV). This is an observational physiological study evaluating the response to a 500-mL fluid challenge in 54 patients receiving PSV, 27 without (Synch) and 27 with asynchronies (Asynch), as assessed by visual inspection of ventilator waveforms by 2 skilled blinded physicians. The area under the curve was 0.71 (confidence interval, 0.57-0.83) for the overall population, 0.86 (confidence interval, 0.68-0.96) in the Synch group, and 0.53 (confidence interval, 0.33-0.73) in the Asynch group (P = .018). Sensitivity and specificity of PPV were 78% and 89% in the Synch group and 36% and 46% in the Asynch group. Logistic regression showed that the PPV prediction was influenced by patient-ventilator asynchrony (odds ratio, 8.8 [2.0-38.0]; P < .003). Of the 27 patients without asynchronies, 12 had a tidal volume greater than or equal to 8 mL/kg; in this subgroup, the rate of correct classification was 100%. Patient-ventilator asynchrony affects PPV performance during partial ventilatory support influencing its efficacy in predicting fluid responsiveness. Copyright © 2015 Elsevier Inc. All rights reserved. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1332921','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1332921">Pressure-induced phase transformation, reversible amorphization, and anomalous visible light response in organolead bromide perovskite</a> <a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a> Wang, Yonggang; Lu, Xujie; Yang, Wenge Hydrostatic pressure, as an alternative of chemical pressure to tune the crystal structure and physical properties, is a significant technique for novel function material design and fundamental research. In this article, we report the phase stability and visible light response of the organolead bromide perovskite, CH 3NH 3PbBr 3 (MAPbBr 3), under hydrostatic pressure up to 34 GPa at room temperature: Two phase transformations below 2 GPa (from Pm3¯m to Im3¯, then to Pnma) and a reversible amorphization starting from about 2 GPa were observed, which could be attributed to the tilting of PbBr 6 octahedra and destroying of long-rangemore » ordering of MA cations, respectively. The visible light response of MAPbBr 3 to pressure was studied by in situ photoluminescence, electric resistance, photocurrent measurements and first-principle simulations. The anomalous band gap evolution during compression with red-shift followed by blue-shift is explained by the competition between compression effect and pressure-induced amorphization. Along with the amorphization process accomplished around 25 GPa, the resistance increased by 5 orders of magnitude while the system still maintains its semiconductor characteristics and considerable response to the visible light irradiation. Lastly, our results not only show that hydrostatic pressure may provide an applicable tool for the organohalide perovskites based photovoltaic device functioning as switcher or controller, but also shed light on the exploration of more amorphous organometal composites as potential light absorber.« less </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1332921-pressure-induced-phase-transformation-reversible-amorphization-anomalous-visible-light-response-organolead-bromide-perovskite','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1332921-pressure-induced-phase-transformation-reversible-amorphization-anomalous-visible-light-response-organolead-bromide-perovskite">Pressure-induced phase transformation, reversible amorphization, and anomalous visible light response in organolead bromide perovskite</a> <a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a> Wang, Yonggang; Lu, Xujie; Yang, Wenge; ... 2015-08-18 Hydrostatic pressure, as an alternative of chemical pressure to tune the crystal structure and physical properties, is a significant technique for novel function material design and fundamental research. In this article, we report the phase stability and visible light response of the organolead bromide perovskite, CH 3NH 3PbBr 3 (MAPbBr 3), under hydrostatic pressure up to 34 GPa at room temperature: Two phase transformations below 2 GPa (from Pm3¯m to Im3¯, then to Pnma) and a reversible amorphization starting from about 2 GPa were observed, which could be attributed to the tilting of PbBr 6 octahedra and destroying of long-rangemore » ordering of MA cations, respectively. The visible light response of MAPbBr 3 to pressure was studied by in situ photoluminescence, electric resistance, photocurrent measurements and first-principle simulations. The anomalous band gap evolution during compression with red-shift followed by blue-shift is explained by the competition between compression effect and pressure-induced amorphization. Along with the amorphization process accomplished around 25 GPa, the resistance increased by 5 orders of magnitude while the system still maintains its semiconductor characteristics and considerable response to the visible light irradiation. Lastly, our results not only show that hydrostatic pressure may provide an applicable tool for the organohalide perovskites based photovoltaic device functioning as switcher or controller, but also shed light on the exploration of more amorphous organometal composites as potential light absorber.« less </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26284441','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26284441">Pressure-Induced Phase Transformation, Reversible Amorphization, and Anomalous Visible Light Response in Organolead Bromide Perovskite.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Wang, Yonggang; Lü, Xujie; Yang, Wenge; Wen, Ting; Yang, Liuxiang; Ren, Xiangting; Wang, Lin; Lin, Zheshuai; Zhao, Yusheng 2015-09-02 Hydrostatic pressure, as an alternative of chemical pressure to tune the crystal structure and physical properties, is a significant technique for novel function material design and fundamental research. In this article, we report the phase stability and visible light response of the organolead bromide perovskite, CH3NH3PbBr3 (MAPbBr3), under hydrostatic pressure up to 34 GPa at room temperature. Two phase transformations below 2 GPa (from Pm3̅m to Im3̅, then to Pnma) and a reversible amorphization starting from about 2 GPa were observed, which could be attributed to the tilting of PbBr6 octahedra and destroying of long-range ordering of MA cations, respectively. The visible light response of MAPbBr3 to pressure was studied by in situ photoluminescence, electric resistance, photocurrent measurements and first-principle simulations. The anomalous band gap evolution during compression with red-shift followed by blue-shift is explained by the competition between compression effect and pressure-induced amorphization. Along with the amorphization process accomplished around 25 GPa, the resistance increased by 5 orders of magnitude while the system still maintains its semiconductor characteristics and considerable response to the visible light irradiation. Our results not only show that hydrostatic pressure may provide an applicable tool for the organohalide perovskites based photovoltaic device functioning as switcher or controller, but also shed light on the exploration of more amorphous organometal composites as potential light absorber. </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_1");'>1</a></li> <li><a href="#" onclick='return showDiv("page_2");'>2</a></li> <li class="active">3</li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_4" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_2");'>2</a></li> <li><a href="#" onclick='return showDiv("page_3");'>3</a></li> <li class="active">4</li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="61"> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23897070','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23897070">Reproducibility of blood pressure responses to dietary sodium and potassium interventions: the GenSalt study.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Gu, Dongfeng; Zhao, Qi; Chen, Jing; Chen, Ji-Chun; Huang, Jianfeng; Bazzano, Lydia A; Lu, Fanghong; Mu, Jianjun; Li, Jianxin; Cao, Jie; Mills, Katherine; Chen, Chung-Shiuan; Rice, Treva; Hamm, L Lee; He, Jiang 2013-09-01 Blood pressure responses to dietary sodium and potassium interventions vary among individuals. We studied the long-term reproducibility of blood pressure responses to dietary sodium and potassium intake. We repeated the dietary sodium and potassium interventions among 487 Chinese adults 4.5 years after the original dietary intervention. The identical dietary intervention protocol, which included a 7-day low-sodium feeding (51.3 mmol/d), a 7-day high-sodium feeding (307.8 mmol/d), and a 7-day high-sodium feeding with oral potassium supplementation (60.0 mmol/d), was applied in both the initial and repeated studies. Three blood pressure measurements were obtained during each of the 3 days of baseline observation and on days 5, 6, and 7 of each intervention period. The results from the 24-hour urinary excretion of sodium and potassium showed excellent compliance with the study diet. Blood pressure responses to dietary intervention in the original and repeated studies were highly correlated. For example, the correlation coefficients (95% confidence interval) for systolic blood pressure levels were 0.77 (0.73-0.80) at baseline, 0.79 (0.75-0.82) during low sodium, 0.80 (0.77-0.83) during high sodium, and 0.82 (0.79-0.85) during high sodium and potassium supplementation interventions (all P<0.0001). The correlation coefficients for systolic blood pressure changes were 0.37 (0.29-0.44) from baseline to low sodium, 0.37 (0.29-0.44) from low to high sodium, and 0.28 (0.20-0.36) from high sodium to high sodium plus potassium supplementation (all P<0.0001). These data indicate that blood pressure responses to dietary sodium and potassium interventions have long-term reproducibility and stable characteristics in the general population. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2009EnGeo..57.1263R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2009EnGeo..57.1263R">Modeling of damage, permeability changes and pressure responses during excavation of the TSX tunnel in granitic rock at URL, Canada</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Rutqvist, Jonny; Börgesson, Lennart; Chijimatsu, Masakazu; Hernelind, Jan; Jing, Lanru; Kobayashi, Akira; Nguyen, Son 2009-05-01 This paper presents numerical modeling of excavation-induced damage, permeability changes, and fluid-pressure responses during excavation of a test tunnel associated with the tunnel sealing experiment (TSX) at the Underground Research Laboratory (URL) in Canada. Four different numerical models were applied using a wide range of approaches to model damage and permeability changes in the excavation disturbed zone (EDZ) around the tunnel. Using in situ calibration of model parameters, the modeling could reproduce observed spatial distribution of damage and permeability changes around the tunnel as a combination of disturbance induced by stress redistribution around the tunnel and by the drill-and-blast operation. The modeling showed that stress-induced permeability increase above the tunnel is a result of micro and macrofracturing under high deviatoric (shear) stress, whereas permeability increase alongside the tunnel is a result of opening of existing microfractures under decreased mean stress. The remaining observed fracturing and permeability changes around the periphery of the tunnel were attributed to damage from the drill-and-blast operation. Moreover, a reasonably good agreement was achieved between simulated and observed excavation-induced pressure responses around the TSX tunnel for 1 year following its excavation. The simulations showed that these pressure responses are caused by poroelastic effects as a result of increasing or decreasing mean stress, with corresponding contraction or expansion of the pore volume. The simulation results for pressure evolution were consistent with previous studies, indicating that the observed pressure responses could be captured in a Biot model using a relatively low Biot-Willis’ coefficient, α ≈ 0.2, a porosity of n ≈ 0.007, and a relatively low permeability of k ≈ 2 × 10-22 m2, which is consistent with the very tight, unfractured granite at the site. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20432375','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20432375">Calcium ion propagation in cultured keratinocytes and other cells in skin in response to hydraulic pressure stimulation.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Goto, Makiko; Ikeyama, Kazuyuki; Tsutsumi, Moe; Denda, Sumiko; Denda, Mitsuhiro 2010-07-01 We have previously suggested that a variety of environmental factors might be first sensed by epidermal keratinocytes, which represent the frontier of the body. To further examine this idea, in the present study, we examined the intracellular calcium responses of cultured keratinocytes to external hydraulic pressure. First, we compared the responses of undifferentiated and differentiated keratinocytes with those of fibroblasts, vascular endothelial cells (VEC), and lymphatic endothelial cells. Elevation of intracellular calcium was observed after application of pressure to keratinocytes, fibroblasts, and VEC. The calcium propagation extended over a larger area and continued for a longer period of time in differentiated keratinocytes, as compared with the other cells. The response of the keratinocytes was dramatically reduced when the cells were incubated in medium without calcium. Application of a non-selective transient receptor potential (TRP) channel blocker also attenuated the calcium response. These results suggest that differentiated keratinocytes are sensitive to external pressure and that TRP might be involved in the mechanism of their response. (c) 2010 Wiley-Liss, Inc. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23648702','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23648702">Blood pressure response to patterns of weather fluctuations and effect on mortality.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Aubinière-Robb, Louise; Jeemon, Panniyammakal; Hastie, Claire E; Patel, Rajan K; McCallum, Linsay; Morrison, David; Walters, Matthew; Dawson, Jesse; Sloan, William; Muir, Scott; Dominiczak, Anna F; McInnes, Gordon T; Padmanabhan, Sandosh 2013-07-01 Very few studies have looked at longitudinal intraindividual blood pressure responses to weather conditions. There are no data to suggest that specific response to changes in weather will have an impact on survival. We analyzed >169 000 clinic visits of 16 010 Glasgow Blood Pressure Clinic patients with hypertension. Each clinic visit was mapped to the mean West of Scotland monthly weather (temperature, sunshine, rainfall) data. Percentage change in blood pressure was calculated between pairs of consecutive clinic visits, where the weather alternated between 2 extreme quartiles (Q(1)-Q(4) or Q(4)-Q(1)) or remained in the same quartile (Q(n)-Q(n)) of each weather parameter. Subjects were also categorized into 2 groups depending on whether their blood pressure response in Q(1)-Q(4) or Q(4)-Q(1) were concordant or discordant to Q(n)-Q(n). Generalized estimating equations and Cox proportional hazards model were used to model the effect on longitudinal blood pressure and mortality, respectively. Q(n)-Q(n) showed a mean 2% drop in blood pressure consistently, whereas Q(4)-Q(1) showed a mean 2.1% and 1.6% rise in systolic and diastolic blood pressure, respectively. However, Q(1)-Q(4) did not show significant changes in blood pressure. Temperature-sensitive subjects had significantly higher mortality (1.35 [95% confidence interval, 1.06-1.71]; P=0.01) and higher follow-up systolic blood pressure (1.85 [95% confidence interval, 0.24-3.46]; P=0.02) compared with temperature-nonsensitive subjects. Blood pressure response to temperature may be one of the underlying mechanisms that determine long-term blood pressure variability. Knowing a patient's blood pressure response to weather can help reduce unnecessary antihypertensive treatment modification, which may in turn increase blood pressure variability and, thus, risk. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25255389','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25255389">Movement of the lacrimal canalicular wall under intracanalicular pressure changes observed with dacryoendoscopy.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Kakizaki, Hirohiko; Takahashi, Yasuhiro; Mito, Hidenori; Nakamura, Yasuhisa 2015-01-01 Movement of the lacrimal canalicular wall has been speculated to occur during blinking. Movement of the common internal ostium has been observed under nasal endoscopy, and pressure changes in the lacrimal canalicular cavity have been observed with a pressure sensor; however, lacrimal canalicular wall movement under pressure changes has not been observed. To examine movement of the lacrimal canalicular wall under intracanalicular pressure changes using dacryoendoscopy. The authors examined 20 obstruction-free lacrimal canaliculi in 10 patients. A dacryoendoscope was inserted, and water was poured into the intracanalicular cavity via the dacryoendoscope's water channel. The water was then poured or suctioned to cause positive or negative pressure changes in the intracanalicular cavity, and movement of the lacrimal canalicular wall was examined. The lacrimal canalicular wall moved flexibly with pressure changes. Under positive pressure, the intracanalicular cavity was dilated; however, it narrowed under negative pressure. The extent of movement was more dramatic in the common canalicular portion than the proximal canalicular portion. Intracanalicular pressure changes cause movement of the lacrimal canalicular wall. There was a consistent relationship between intracanalicular cavity changes and pressure changes, possibly contributing to lacrimal drainage of the canaliculus. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19283590','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19283590">Moderate pressure massage elicits a parasympathetic nervous system response.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Diego, Miguel A; Field, Tiffany 2009-01-01 Twenty healthy adults were randomly assigned to a moderate pressure or a light pressure massage therapy group, and EKGs were recorded during a 3-min baseline, during the 15-min massage period and during a 3-min postmassage period. EKG data were then used to derive the high frequency (HF), low frequency (LF) components of heart rate variability and the low to high frequency ratio (LF/HF) as noninvasive markers of autonomic nervous system activity. The participants who received the moderate pressure massage exhibited a parasympathetic nervous system response characterized by an increase in HF, suggesting increased vagal efferent activity and a decrease in the LF/HF ratio, suggesting a shift from sympathetic to parasympathetic activity that peaked during the first half of the massage period. On the other hand, those who received the light pressure massage exhibited a sympathetic nervous system response characterized by decreased HF and increased LF/HF. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21471995','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21471995">Limb venous compliance responses to lower body negative pressure in humans with high blood pressure.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Goulopoulou, S; Deruisseau, K C; Carhart, R; Kanaley, J A 2012-05-01 This study tested the hypothesis that limb venous responses to baroreceptor unloading are altered in individuals with high blood pressure (HBP) compared with normotensive (NT) controls. Calf venous compliance was assessed in 20 subjects with prehypertension and stage-1 hypertension (mean arterial pressure, MAP: 104±1 mm Hg) and 13 NT controls (MAP: 86±2 mm Hg) at baseline and during lower body negative pressure (LBNP), using venous occlusion plethysmography. Baroreflex sensitivity (BRS) was measured using the sequence technique and total peripheral resistance (TPR) was estimated from finger plethysmography. Baseline venous compliance was not different between groups, but the HBP group had lower baseline lnBRS (2.22±0.14 vs 2.7±0.18 ms mm Hg(-1)) and greater baseline TPR (3828±138 vs 3250±111 dyn sec(-1) cm(-5) m(2), P<0.05). Calf venous compliance was reduced in response to LBNP only in the NT group (P<0.05). The HBP group had a greater increase in TPR (ΔTPR) compared with the NT group (+1649±335 vs +718±196 dyn sec(-1) cm(-5) m(2), P<0.05). In conclusion, the early stages of hypertension are characterized by an attenuated venoconstrictor response to baroreceptor unloading, which may compensate for an exaggerated vasoconstrictor response and protect against further increases in blood pressure. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20050000311&hterms=Biomechanics&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D70%26Ntt%3DBiomechanics','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20050000311&hterms=Biomechanics&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D70%26Ntt%3DBiomechanics">Cardiovascular regulation in humans in response to oscillatory lower body negative pressure</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Levenhagen, D. K.; Evans, J. M.; Wang, M.; Knapp, C. F. 1994-01-01 The frequency response characteristics of human cardiovascular regulation during hypotensive stress have not been determined. We therefore exposed 10 male volunteers to seven frequencies (0.004-0.1 Hz) of oscillatory lower body negative pressure (OLBNP; 0-50 mmHg). Fourier spectra of arterial pressure (AP), central venous pressure (CVP), stroke volume (SV), cardiac output (CO), heart rate (HR), and total peripheral resistance (TPR) were determined and first harmonic mean, amplitude, and phase angles with respect to OLBNP are presented. AP was relatively well regulated as demonstrated by small oscillations in half amplitude (3.5 mmHg) that were independent of OLBNP frequency and similar to unstressed control spectra. Due to the biomechanics of the system, the magnitudes of oscillations in calf circumference (CC) and CVP decreased with increasing frequency; therefore, we normalized responses by these indexes of the fluid volume shifted. The ratios of oscillations in AP to oscillations in CC increased by an order of magnitude, whereas oscillations in CVP to oscillations in CC and oscillations in AP to oscillations in CVP both tripled between 0.004 and 0.1 Hz. Therefore, even though the amount of fluid shifted by OLBNP decreased with increasing frequency, the magnitude of both CVP and AP oscillations per volume of fluid shifted increased (peaking at 0.08 Hz). The phase relationships between variables, particularly the increasing lags in SV and TPR, but not CVP, indicated that efferent responses with lags of 5-6 s could account for the observed responses. We conclude that, at frequencies below 0.02 Hz, the neural system of humans functioned optimally in regulating AP; OLBNP-induced decreases in SV (by as much as 50%) were counteracted by appropriate oscillations in HR and TPR responses. As OLBNP frequency increased, SV, TPR, and HR oscillations increasingly lagged the input and became less optimally timed for AP regulation. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19760018239','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19760018239">Response of space shuttle insulation panels to acoustic noise pressure</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Vaicaitis, R. 1976-01-01 The response of reusable space shuttle insulation panels to random acoustic pressure fields are studied. The basic analytical approach in formulating the governing equations of motion uses a Rayleigh-Ritz technique. The input pressure field is modeled as a stationary Gaussian random process for which the cross-spectral density function is known empirically from experimental measurements. The response calculations are performed in both frequency and time domain. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017IJBm...61..181H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017IJBm...61..181H">The major influence of the atmosphere on intracranial pressure: an observational study</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Herbowski, Leszek 2017-01-01 The impact of the atmosphere on human physiology has been studied widely within the last years. In practice, intracranial pressure is a pressure difference between intracranial compartments and the surrounding atmosphere. This means that gauge intracranial pressure uses atmospheric pressure as its zero point, and therefore, this method of pressure measurement excludes the effects of barometric pressure's fluctuation. The comparison of these two physical quantities can only take place through their absolute value relationship. The aim of this study is to investigate the direct effect of barometric pressure on the absolute intracranial pressure homeostasis. A prospective observational cross-sectional open study was conducted in Szczecin, Poland. In 28 neurosurgical patients with suspected normal-pressure hydrocephalus, intracranial intraventricular pressure was monitored in a sitting position. A total of 168 intracranial pressure and atmospheric pressure measurements were performed. Absolute atmospheric pressure was recorded directly. All values of intracranial gauge pressure were converted to absolute pressure (the sum of gauge intracranial pressure and local absolute atmospheric pressure). The average absolute mean intracranial pressure in the patients is 1006.6 hPa (95 % CI 1004.5 to 1008.8 hPa, SEM 1.1), and the mean absolute atmospheric pressure is 1007.9 hPa (95 % CI 1006.3 to 1009.6 hPa, SEM 0.8). The observed association between atmospheric and intracranial pressure is strongly significant (Spearman correlation r = 0.87, p < 0.05) and all the measurements are perfectly reliable (Bland-Altman coefficient is 4.8 %). It appears from this study that changes in absolute intracranial pressure are related to seasonal variation. Absolute intracranial pressure is shown to be impacted positively by atmospheric pressure. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=push+AND+back&pg=4&id=EJ749441','ERIC'); return false;" href="https://eric.ed.gov/?q=push+AND+back&pg=4&id=EJ749441">One Reading Specialist's Response to High-Stakes Testing Pressures</a> <a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a> Assaf, Lori 2006-01-01 Pressures to help students pass high-stakes tests affect teachers' reading instruction, their responsiveness to students' learning needs, and their professional effectiveness. This article reports on how one reading specialist responded to testing pressures in her urban elementary school. She believed that what was "right" for her… </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/1064699-review-a2b2o7-pyrochlore-response-irradiation-pressure','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/1064699-review-a2b2o7-pyrochlore-response-irradiation-pressure">Review of A 2B 2O 7 Pyrochlore Response to Irradiation and Pressure</a> <a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a> Lang, Maik; Zhang, Fuxiang; Zhang, Jiaming 2010-10-01 This article reviews recent research on swift heavy-ion irradiations and high-pressure studies on pyrochlores of the Gd 2Zr 2-xTi xO 7 binary. Applying three complementary analytical techniques (synchrotron X-ray diffraction, Raman spectroscopy and transmission electron microscopy) allowed for the investigation of the response of pyrochlore to irradiation and/or pressure. The chemical composition of pyrochlore has a strong effect on the character and energetics of the type of structural modifications that can be obtained under pressure or irradiation: For Ti-rich pyrochlores, the crystalline-to-amorphous transition is the dominant process. When Zr is substituted for Ti, an order–disorder transformation to the defect-fluorite structuremore » becomes the increasingly dominant process. Except for Gd 2Zr 2O 7, single ion tracks in pyrochlore consist of an amorphous core, surrounded by a crystalline, but disordered, defect-fluorite shell. This shell is surrounded by a defect-rich pyrochlore region. In contrast to similar effects observed when pressure or irradiation are applied separately, the response of the pyrochlore structure is significantly different when it is exposed simultaneously to pressure and irradiation. The combination of relativistic heavy ions with high pressure results in the formation of a new metastable pyrochlore phase. TEM and quantum–mechanical calculations suggest that these novel structural modifications are caused by the formation of nanocrystals and the modified energetics of nanomaterials.« less </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/1019901-review-a2b2o7-pyrochlore-response-irradiation-pressure','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/1019901-review-a2b2o7-pyrochlore-response-irradiation-pressure">Review of A2B2O7 Pyrochlore Response to Irradiation and Pressure</a> <a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a> Lang, M.; Zhang, F; Zhang, J 2010-01-01 This article reviews recent research on swift heavy-ion irradiations and high-pressure studies on pyrochlores of the Gd{sub 2}Zr{sub 2-x}Ti{sub x}O{sub 7} binary. Applying three complementary analytical techniques (synchrotron X-ray diffraction, Raman spectroscopy and transmission electron microscopy) allowed for the investigation of the response of pyrochlore to irradiation and/or pressure. The chemical composition of pyrochlore has a strong effect on the character and energetics of the type of structural modifications that can be obtained under pressure or irradiation: For Ti-rich pyrochlores, the crystalline-to-amorphous transition is the dominant process. When Zr is substituted for Ti, an order-disorder transformation to the defect-fluorite structuremore » becomes the increasingly dominant process. Except for Gd{sub 2}Zr{sub 2}O{sub 7}, single ion tracks in pyrochlore consist of an amorphous core, surrounded by a crystalline, but disordered, defect-fluorite shell. This shell is surrounded by a defect-rich pyrochlore region. In contrast to similar effects observed when pressure or irradiation are applied separately, the response of the pyrochlore structure is significantly different when it is exposed simultaneously to pressure and irradiation. The combination of relativistic heavy ions with high pressure results in the formation of a new metastable pyrochlore phase. TEM and quantum-mechanical calculations suggest that these novel structural modifications are caused by the formation of nanocrystals and the modified energetics of nanomaterials.« less </li> <li> <a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19800023291','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19800023291">Observation of pressure variation in the cavitation region of submerged journal bearings</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Etsion, I.; Ludwig, L. P. 1980-01-01 Visual observations and pressure measurements in the cavitation zone of a submerged journal bearing are described. Tests were performed at various shaft speeds and ambient pressure levels. Some photographs of the cavitation region are presented showing strong reverse flow at the downstream end of the region. Pressure profiles are presented showing significant pressure variations inside the cavitation zone, contrary to common assumptions of constant cavitation pressure. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26737818','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26737818">Acoustic pressure reduction at rhythm deviants causes magnetoencephalographic response.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Takeshita, Yuya; Yokosawa, Koichi 2015-01-01 Rhythm is an element of music and is important for determining the impression of the music. To investigate the mechanism by which musical rhythmic changes are perceived, magnetoencephalographic responses to rhythm deviants were recorded from 11 healthy volunteers. Auditory stimuli consisting of physically controlled tones were adapted from a song. The auditory stimuli had a steady rhythm, but "early" and "late" deviants were inserted. Only the "early" deviant, which was a tone with a short duration, caused N100m-like prominent transient responses at around the offset of the deviant tone. The latency of the prominent response depended on the descending sound pressure of the deviant tone and was 65 ms after 50% descent. The results suggest that unexpected shortening of tone in a continuous rhythm evokes a transient response and that the response is caused by descending sound pressure of the shortened tone itself, not by the following tones. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014EGUGA..1615548T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014EGUGA..1615548T">Pressure Variations in Metamorphic Rocks: Implications for the Interpretation of Petrographic Observations</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Tajčmanová, Lucie 2014-05-01 Metamorphic petrologists and structural geologists, using direct measurements, bring the only direct observational constrains for validating geodynamic models. Therefore, petrological and structural geological observations are essential for the quality and reproducibility of geodynamic reconstructions and models. One of the important assumptions for geodynamic reconstructions arises from the pressure and temperature estimates in the petrology analysis. Pressure is commonly converted to depth through the equation for lithostatic pressure and so the original position of the rock sample within the Earth's interior can be constrained. The current assumption that the studied sample corresponds to uniform pressure may not be correct, and if so, it has serious implications. Increasing evidence from analytical data shows that pressure is not constant even on a grain scale, posing new challenges because, if ignored, it leads to an incorrect use of petrology data in constraining geodynamic models. Well known examples of the preservation of coesite and diamond in a host mineral like garnet show that high pressure inclusions are preserved during decompression. Tajčmanová et al. (2014) has shown that grain-scale pressure variations can develop and that these pressure variations allow compositional zoning in minerals preserved over geological time scales. A new unconventional barometric method based on equilibrium under pressure variations has been developed . Such pressure variations are also connected with differences in fluid pressure in open systems and can be thus observed at all scales. Tajčmanová L., Podladchikov Y., Powell R., Moulas E., Vrijmoed J. and Connolly J. (2014). Grain scale pressure variations and chemical equilibrium in high-grade metamorphic rocks.Journal of Metamorphic Geology, doi:10.1111/jmg.12066 This work was supported by ERC starting grant 335577 to Lucie Tajcmanova </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3087400','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3087400">Modeling subharmonic response from contrast microbubbles as a function of ambient static pressure</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Katiyar, Amit; Sarkar, Kausik; Forsberg, Flemming 2011-01-01 Variation of subharmonic response from contrast microbubbles with ambient pressure is numerically investigated for non-invasive monitoring of organ-level blood pressure. Previously, several contrast microbubbles both in vitro and in vivo registered approximately linear (5–15 dB) subharmonic response reduction with 188 mm Hg change in ambient pressure. In contrast, simulated subharmonic response from a single microbubble is seen here to either increase or decrease with ambient pressure. This is shown using the code BUBBLESIM for encapsulated microbubbles, and then the underlying dynamics is investigated using a free bubble model. The ratio of the excitation frequency to the natural frequency of the bubble is the determining parameter—increasing ambient pressure increases natural frequency thereby changing this ratio. For frequency ratio below a lower critical value, increasing ambient pressure monotonically decreases subharmonic response. Above an upper critical value of the same ratio, increasing ambient pressure increases subharmonic response; in between, the subharmonic variation is non-monotonic. The precise values of frequency ratio for these three different trends depend on bubble radius and excitation amplitude. The modeled increase or decrease of subharmonic with ambient pressure, when one happens, is approximately linear only for certain range of excitation levels. Possible reasons for discrepancies between model and previous experiments are discussed. PMID:21476688 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27333899','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27333899">The major influence of the atmosphere on intracranial pressure: an observational study.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Herbowski, Leszek 2017-01-01 The impact of the atmosphere on human physiology has been studied widely within the last years. In practice, intracranial pressure is a pressure difference between intracranial compartments and the surrounding atmosphere. This means that gauge intracranial pressure uses atmospheric pressure as its zero point, and therefore, this method of pressure measurement excludes the effects of barometric pressure's fluctuation. The comparison of these two physical quantities can only take place through their absolute value relationship. The aim of this study is to investigate the direct effect of barometric pressure on the absolute intracranial pressure homeostasis. A prospective observational cross-sectional open study was conducted in Szczecin, Poland. In 28 neurosurgical patients with suspected normal-pressure hydrocephalus, intracranial intraventricular pressure was monitored in a sitting position. A total of 168 intracranial pressure and atmospheric pressure measurements were performed. Absolute atmospheric pressure was recorded directly. All values of intracranial gauge pressure were converted to absolute pressure (the sum of gauge intracranial pressure and local absolute atmospheric pressure). The average absolute mean intracranial pressure in the patients is 1006.6 hPa (95 % CI 1004.5 to 1008.8 hPa, SEM 1.1), and the mean absolute atmospheric pressure is 1007.9 hPa (95 % CI 1006.3 to 1009.6 hPa, SEM 0.8). The observed association between atmospheric and intracranial pressure is strongly significant (Spearman correlation r = 0.87, p < 0.05) and all the measurements are perfectly reliable (Bland-Altman coefficient is 4.8 %). It appears from this study that changes in absolute intracranial pressure are related to seasonal variation. Absolute intracranial pressure is shown to be impacted positively by atmospheric pressure. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22892922','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22892922">Pulse pressure variation and prediction of fluid responsiveness in patients ventilated with low tidal volumes.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Oliveira-Costa, Clarice Daniele Alves de; Friedman, Gilberto; Vieira, Sílvia Regina Rios; Fialkow, Léa 2012-07-01 To determine the utility of pulse pressure variation (ΔRESP PP) in predicting fluid responsiveness in patients ventilated with low tidal volumes (V T) and to investigate whether a lower ΔRESP PP cut-off value should be used when patients are ventilated with low tidal volumes. This cross-sectional observational study included 37 critically ill patients with acute circulatory failure who required fluid challenge. The patients were sedated and mechanically ventilated with a V T of 6-7 ml/kg ideal body weight, which was monitored with a pulmonary artery catheter and an arterial line. The mechanical ventilation and hemodynamic parameters, including ΔRESP PP, were measured before and after fluid challenge with 1,000 ml crystalloids or 500 ml colloids. Fluid responsiveness was defined as an increase in the cardiac index of at least 15%. ClinicalTrial.gov: NCT01569308. A total of 17 patients were classified as responders. Analysis of the area under the ROC curve (AUC) showed that the optimal cut-off point for ΔRESP PP to predict fluid responsiveness was 10% (AUC = 0.74). Adjustment of the ΔRESP PP to account for driving pressure did not improve the accuracy (AUC = 0.76). A ΔRESP PP ≥ 10% was a better predictor of fluid responsiveness than central venous pressure (AUC = 0.57) or pulmonary wedge pressure (AUC = 051). Of the 37 patients, 25 were in septic shock. The AUC for ΔRESP PP ≥ 10% to predict responsiveness in patients with septic shock was 0.484 (sensitivity, 78%; specificity, 93%). The parameter D RESP PP has limited value in predicting fluid responsiveness in patients who are ventilated with low tidal volumes, but a ΔRESP PP>10% is a significant improvement over static parameters. A ΔRESP PP ≥ 10% may be particularly useful for identifying responders in patients with septic shock. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3093244','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3093244">Air Pressure Responses to Sudden Vocal Tract Pressure Bleeds During Production of Stop Consonants: New Evidence of Aeromechanical Regulation</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Zajac, David J.; Weissler, Mark C. 2011-01-01 Two studies were conducted to evaluate short-latency vocal tract air pressure responses to sudden pressure bleeds during production of voiceless bilabial stop consonants. It was hypothesized that the occurrence of respiratory reflexes would be indicated by distinct patterns of responses as a function of bleed magnitude. In Study 1, 19 adults produced syllable trains of /pΛ/ using a mouthpiece coupled to a computer-controlled perturbator. The device randomly created bleed apertures that ranged from 0 to 40 mm2 during production of the 2nd or 4th syllable of an utterance. Although peak oral air pressure dropped in a linear manner across bleed apertures, it averaged 2 to 3 cm H2O at the largest bleed. While slope of oral pressure also decreased in a linear trend, duration of the oral pressure pulse remained relatively constant. The patterns suggest that respiratory reflexes, if present, have little effect on oral air pressure levels. In Study 2, both oral and subglottal air pressure responses were monitored in 2 adults while bleed apertures of 20 and 40 mm2 were randomly created. For 1 participant, peak oral air pressure dropped across bleed apertures, as in Study 1. Subglottal air pressure and slope, however, remained relatively stable. These patterns provide some support for the occurrence of respiratory reflexes to regulate subglottal air pressure. Overall, the studies indicate that the inherent physiologic processes of the respiratory system, which may involve reflexes, and passive aeromechanical resistance of the upper airway are capable of developing oral air pressure in the face of substantial pressure bleeds. Implications for understanding speech production and the characteristics of individuals with velopharyngeal dysfunction are discussed. PMID:15324286 </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_2");'>2</a></li> <li><a href="#" onclick='return showDiv("page_3");'>3</a></li> <li class="active">4</li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_5" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_3");'>3</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li class="active">5</li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="81"> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22828668','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22828668">Exaggerated blood pressure response to exercise in athletes: dysmetabolism or altered autonomic nervous system modulation?</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Turmel, Julie; Bougault, Valérie; Boulet, Louis-Philippe; Poirier, Paul 2012-10-01 The importance of exercise-induced exaggerated blood pressure (BP) response in endurance athletes is not known. To assess the hemodynamic parameters and metabolic profile in athletes with an exaggerated BP response to exercise. Forty-four endurance athletes underwent a maximal exercise test, a 24-h ambulatory blood pressure monitoring, a 24-h Holter assessment, and sampling of blood on two occasions: (a) during intense training and (b) following 3 weeks without training. During the training period, 11 athletes showed an exaggerated BP response to exercise, whereas seven of these 11 athletes also showed an exaggerated BP response during the resting period. Elevation in systolic BP was greater in athletes with an exaggerated BP response than athletes with a normal BP response to exercise (resting: 84 ± 22 vs. 60 ± 18 mmHg, P = 0.02; training: 100 ± 21 vs. 70 ± 18 mmHg, P = 0.004). During the training period, athletes with an exaggerated BP response to exercise showed higher systolic BP values on 24-h ambulatory blood pressure monitoring (136 ± 15 vs. 118 ± 8 mmHg, P = 0.02). During the resting period, athletes with an exaggerated BP response to exercise had lower apolipoprotein-A1 (1.3 ± 0.1 vs. 1.5 ± 0.2 g/l, P = 0.009), and higher SDNN (259 ± 47 vs. 209 ± 52 ms, P = 0.03) and pNN50 (0.4 ± 0.1 vs. 0.3 ± 0.1%, P = 0.05). These observations may represent the first sign of a slight metabolic disturbance associated with vascular wall abnormalities, although the parameters remain within normal values. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=respiratory+AND+system&pg=6&id=EJ696527','ERIC'); return false;" href="https://eric.ed.gov/?q=respiratory+AND+system&pg=6&id=EJ696527">Air Pressure Responses to Sudden Vocal Tract Pressure Bleeds during Production of Stop Consonants: New Evidence of Aeromechanical Regulation.</a> <a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a> Zajac, David J.; Weissler, Mark C. 2004-01-01 Two studies were conducted to evaluate short-latency vocal tract air pressure responses to sudden pressure bleeds during production of voiceless bilabial stop consonants. It was hypothesized that the occurrence of respiratory reflexes would be indicated by distinct patterns of responses as a function of bleed magnitude. In Study 1, 19 adults… </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018JASTP.171..111Z','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018JASTP.171..111Z">The zonal-mean and regional tropospheric pressure responses to changes in ionospheric potential</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Zhou, Limin; Tinsley, Brian; Wang, Lin; Burns, Gary 2018-06-01 Global reanalysis data reveal daily surface pressure responses to changes in the global ionospheric potential in both polar and sub-polar regions. We use 21 years of data to show that the pressure response to externally-induced ionospheric potential changes, that are due to the interplanetary magnetic field east-west (IMF By) component, are present in two separate decadal intervals, and follow the opposite ionospheric potential changes in the Arctic and Antarctic for a given By. We use the 4 years of available data to show that the pressure responses to changes in internally generated ionospheric potential, that are caused by low-latitude thunderstorms and highly electrified clouds, agree in sign and sensitivity with those externally generated. We have determined that the daily varying pressure responses are stronger in local winter and spring. The pressure responses at polar latitudes are predominantly over the Antarctic and Greenland ice caps, and those at sub-polar latitudes are of opposite sign, mainly over oceans. A lead-lag analysis confirms that the responses maximize within two days of the ionospheric potential input. Regions of surface pressure fluctuating by about 4 hPa in winter are found with ionospheric potential changes of about 40 kV. The consistent pressure response to the independent external and internal inputs strongly supports the reality of a cloud microphysical mechanism affected by the global electric circuit. A speculative mechanism involves the ionosphere-earth current density Jz, which produces space charge at cloud boundaries and electrically charged droplets and aerosol particles. Ultrafine aerosol particles, under the action of electro-anti-scavenging, are enabled to grow to condensation nuclei size, affecting cloud microphysics and cloud opacity and surface pressure on time scales of hours. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1991RScI...62.2193N','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1991RScI...62.2193N">A 'Quad-Disc' static pressure probe for measurement in adverse atmospheres - With a comparative review of static pressure probe designs</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Nishiyama, Randall T.; Bedard, Alfred J., Jr. 1991-09-01 There are many areas of need for accurate measurements of atmospheric static pressure. These include observations of surface meteorology, airport altimeter settings, pressure distributions around buildings, moving measurement platforms, as well as basic measurements of fluctuating pressures in turbulence. Most of these observations require long-term observations in adverse environments (e.g., rain, dust, or snow). Currently, many pressure measurements are made, of necessity, within buildings, thus involving potential errors of several millibars in mean pressure during moderate winds, accompanied by large fluctuating pressures induced by the structure. In response to these needs, a 'Quad-Disk' pressure probe for continuous, outdoor monitoring purposes was designed which is inherently weather-protected. This Quad-Disk probe has the desirable features of omnidirectional response and small error in pitch. A review of past static pressure probes contrasts design approaches and capabilities. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16514654','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16514654">Chondrocyte response to cyclic hydrostatic pressure in alginate versus pellet culture.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Elder, Steven H; Sanders, Shawn W; McCulley, William R; Marr, Misti L; Shim, Joon W; Hasty, Karen A 2006-04-01 Cells are often cultured at high density (e.g., confluent monolayer and as pellets) to promote chondrogenic differentiation and to maintain the chondrocyte phenotype. They are also frequently suspended in hydrogels such as agarose or alginate for the same purposes. These culture techniques differ markedly with respect to frequency of direct contact between cells and overall intercellular spacing. Because these factors may significantly affect mechanotransduction, the purpose of this study was to determine if the response of articular chondrocytes to cyclic hydrostatic pressure would depend on the culture condition. Primary articular chondrocytes from young and mature pigs were cultured either as pellets or suspended in alginate beads. Both groups were exposed to dynamic hydrostatic pressure (4 MPa, 1 Hz, 5400 cycles per day) for 7 days. Cell proliferation was unaffected by pressure, but pressurized chondrocytes in pellet culture had significantly greater sGAG content and incorporated [3H]proline at a higher rate than nonpressurized controls. Electron microscopy revealed a fibrous extracellular matrix (ECM) surrounding pellets, but not cells in alginate. In addition, expression of Connexin 43 (Cx43) mRNA was slightly lower in alginate than in pellet cultures and was not significantly altered by loading. Thus, metabolic response of chondrocytes to dynamic hydrostatic pressure was affected by culture technique; chondrocytes cultured as pellets exhibited the classical anabolic response to dynamic hydrostatic pressure, but those in alginate did not. Although cell-ECM interaction could be important, the differential response is not likely attributable to differential expression of Cx43 mRNA. Copyright 2006 Orthopaedic Research Society </li> <li> <a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19780010735','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19780010735">Influence of central venous pressure upon sinus node responses to arterial baroreflex stimulation in man</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Mark, A. L.; Takeshita, A.; Eckberg, D. L.; Abboud, F. M. 1978-01-01 Measurements were made of sinus node responses to arterial baroreceptor stimulation with phenylephrine injection or neck suction, before and during changes of central venous pressure provoked by lower body negative pressure or leg and lower truck elevation. Variations of central venous pressure between 1.1 and 9.0 mm Hg did not influence arterial baroreflex mediated bradycardia. Baroreflex sinus node responses were augmented by intravenous propranolol, but the level of responses after propranolol was comparable during the control state, lower body negative pressure, and leg and trunk elevation. Sinus node responses to very brief baroreceptor stimuli applied during the transitions of central venous pressure also were comparable in the three states. The authors conclude that physiological variations of central venous pressure do not influence sinus node responses to arterial baroreceptor stimulation in man. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/17205218','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/17205218">Urethral pressure response patterns induced by squeeze in continent and incontinent women.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Teleman, Pia M; Mattiasson, Anders 2007-09-01 Our aim was to compare the urethral pressure response pattern to pelvic floor muscle contractions in 20-27 years old, nulliparous continent women (n = 31) to that of continent (n = 28) and formerly untreated incontinent (n = 59) (53-63 years old) women. These women underwent urethral pressure measurements during rest and repeated pelvic muscle contractions. The response to the contractions was graded 0-4. The young continent women showed a mean urethral pressure response of 2.8, the middle-aged continent women 2.2 (NS vs young continent), and the incontinent women 1.5 (p < 0.05 vs middle-aged continent, p < 0.001 vs young continent). Urethral pressures during rest were significantly higher in the younger women than in both groups of middle-aged women. The decreased ability to increase urethral pressure on demand seen in middle-aged incontinent women compared to continent women of the same age as well as young women seems to be a consequence of a neuromuscular disorder rather than of age. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20040089958&hterms=Blood+pressure&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D20%26Ntt%3DBlood%2Bpressure','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20040089958&hterms=Blood+pressure&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D20%26Ntt%3DBlood%2Bpressure">The effect of blood volume loss on cardiovascular response to lower body negative pressure using a mathematical model</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Karam, E. H.; Srinivasan, R. S.; Charles, J. B.; Fortney, S. M. 1994-01-01 Different mathematical models of varying complexity have been proposed in recent years to study the cardiovascular (CV) system. However, only a few of them specifically address the response to lower body negative pressure (LBNP), a stress that can be applied in weightlessness to predict changes in orthostatic tolerance. Also, the simulated results produced by these models agree only partially with experimental observations. In contrast, the model proposed by Melchior et al., and modified by Karam et al. is a simple representation of the CV system capable of accurately reproducing observed LBNP responses up to presyncopal levels. There are significant changes in LBNP response due to a loss of blood volume and other alterations that occur in weightlessness and related one-g conditions such as bedrest. A few days of bedrest can cause up to 15% blood volume loss (BVL), with consequent decreases in both stroke volume and cardiac output, and increases in heart rate, mean arterial pressure, and total peripheral resistance. These changes are more pronounced at higher levels of LBNP. This paper presents the results of a simulation study using our CV model to examine the effect of BVL on LBNP response. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018PhRvB..97w5202W','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018PhRvB..97w5202W">Pressure-induced structural and electronic transitions, metallization, and enhanced visible-light responsiveness in layered rhenium disulphide</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Wang, Pei; Wang, Yonggang; Qu, Jingyu; Zhu, Qiang; Yang, Wenge; Zhu, Jinlong; Wang, Liping; Zhang, Weiwei; He, Duanwei; Zhao, Yusheng 2018-06-01 Triclinic rhenium disulphide (Re S2 ) is a promising candidate for postsilicon electronics because of its unique optic-electronic properties. The electrical and optical properties of Re S2 under high pressure, however, remain unclear. Here we present a joint experimental and theoretical study on the structure, electronic, and vibrational properties, and visible-light responses of Re S2 up to 50 GPa. There is a direct-to-indirect band-gap transition in 1 T -Re S2 under low-pressure regime up to 5 GPa. Upon further compression, 1 T -Re S2 undergoes a structural transition to distorted-1 T' phase at 7.7 GPa, followed by the isostructural metallization at 38.5 GPa. Both in situ Raman spectrum and electronic structure analysis reveal that interlayer sulfur-sulfur interaction is greatly enhanced during compression, leading to the remarkable modifications on the electronic properties observed in our subsequent experimental measurements, such as band-gap closure and enhanced photoresponsiveness. This study demonstrates the critical role of pressure in tuning materials properties and the potential usage of layered Re S2 for pressure-responsive optoelectronic applications. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25309965','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25309965">The Responsivity of a Miniaturized Passive Implantable Wireless Pressure Sensor.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Jiang, Hao; Lan, Di; Goldman, Ken; Etemadi, Mozziyar; Shahnasser, Hamid; Roy, Shuvo 2011-01-01 A miniature batteryless implantable wireless pressure sensor that can be used deep inside the body is desired by the medical community. MEMS technology makes it possible to achieve high responsivity that directly determines the operating distance between a miniature implanted sensor and the external RF probe, while providing the read-out. In this paper, for the first time, an analytical expression of the system responsivity versus the sensor design is derived using an equivalent circuit model. Also, the integration of micro-coil inductors and pressure sensitive capacitors on a single silicon chip using MEMS fabrication techniques is demonstrated. Further, the derived analytical design theory is validated by the measured responsivity of these sensors. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=aerodynamics&pg=5&id=EJ823335','ERIC'); return false;" href="https://eric.ed.gov/?q=aerodynamics&pg=5&id=EJ823335">Respiratory and Laryngeal Responses to an Oral Air Pressure Bleed during Speech</a> <a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a> Huber, Jessica E.; Stathopoulos, Elaine T. 2003-01-01 Researchers have hypothesized that the respiratory and laryngeal speech subsystems would respond to an air pressure bleed, but these responses have not been empirically studied. The present study examined the nature of the responses of the respiratory and laryngeal subsystems to an air pressure bleed in order to provide information relevant to the… </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24361920','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24361920">Does the accuracy of blood pressure measurement correlate with hearing loss of the observer?</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Song, Soohwa; Lee, Jongshill; Chee, Youngjoon; Jang, Dong Pyo; Kim, In Young 2014-02-01 The auscultatory method is influenced by the hearing level of the observers. If the observer has hearing loss, it is possible to measure blood pressure inaccurately by misreading the Korotkoff sounds at systolic blood pressure (SBP) and diastolic blood pressure (DBP). Because of the potential clinical problems this discrepancy may cause, we used a hearing loss simulator to determine how hearing level affects the accuracy of blood pressure measurements. Two data sets (data set A, 32 Korotkoff sound video clips recorded by the British Hypertension Society; data set B, 28 Korotkoff sound data acquired from the Korotkoff sound recording system developed by Hanyang University) were used and all the data were attenuated to simulate a hearing loss of 5, 10, 15, 20, and 25 dB using the hearing loss simulator. Five observers with normal hearing assessed the blood pressures from these data sets and the differences between the values measured from the original recordings (no attenuation) and the attenuated versions were analyzed. Greater attenuation of the Korotkoff sounds, or greater hearing loss, resulted in larger blood pressure measurement differences when compared with the original data. When measuring blood pressure with hearing loss, the SBP tended to be underestimated and the DBP was overestimated. The mean differences between the original data and the 25 dB hearing loss data for the two data sets combined were 1.55±2.71 and -4.32±4.21 mmHg for SBP and DBP, respectively. This experiment showed that the accuracy of blood pressure measurements using the auscultatory method is affected by observer hearing level. Therefore, to reduce possible error using the auscultatory method, observers' hearing should be tested. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22521951-energetic-particle-pressure-interplanetary-shocks-stereo-observations','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22521951-energetic-particle-pressure-interplanetary-shocks-stereo-observations">ENERGETIC PARTICLE PRESSURE AT INTERPLANETARY SHOCKS: STEREO-A OBSERVATIONS</a> <a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a> Lario, D.; Decker, R. B.; Roelof, E. C. 2015-11-10 We study periods of elevated energetic particle intensities observed by STEREO-A when the partial pressure exerted by energetic (≥83 keV) protons (P{sub EP}) is larger than the pressure exerted by the interplanetary magnetic field (P{sub B}). In the majority of cases, these periods are associated with the passage of interplanetary shocks. Periods when P{sub EP} exceeds P{sub B} by more than one order of magnitude are observed in the upstream region of fast interplanetary shocks where depressed magnetic field regions coincide with increases of energetic particle intensities. When solar wind parameters are available, P{sub EP} also exceeds the pressure exertedmore » by the solar wind thermal population (P{sub TH}). Prolonged periods (>12 hr) with both P{sub EP} > P{sub B} and P{sub EP} > P{sub TH} may also occur when energetic particles accelerated by an approaching shock encounter a region well upstream of the shock characterized by low magnetic field magnitude and tenuous solar wind density. Quasi-exponential increases of the sum P{sub SUM} = P{sub B} + P{sub TH} + P{sub EP} are observed in the immediate upstream region of the shocks regardless of individual changes in P{sub EP}, P{sub B}, and P{sub TH}, indicating a coupling between P{sub EP} and the pressure of the background medium characterized by P{sub B} and P{sub TH}. The quasi-exponential increase of P{sub SUM} implies a radial gradient ∂P{sub SUM}/∂r > 0 that is quasi-stationary in the shock frame and results in an outward force applied to the plasma upstream of the shock. This force can be maintained by the mobile energetic particles streaming upstream of the shocks that, in the most intense events, drive electric currents able to generate diamagnetic cavities and depressed solar wind density regions.« less </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1992pvp..confR..21R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1992pvp..confR..21R">Monitoring structural response in pressurized environments. Part 2: Applications</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Roach, D. P. There are various methods which can be used to monitor the structural response of electrical components, weapon systems, pressure vessels, submerged pipelines, deep sea vehicles and offshore structures. Numerous experimental techniques have been developed at Sandia National Labs in order to measure the strain, displacement and acceleration of a structural member. These techniques have been successfully implemented in adverse environments of 25 ksi and 300 F. A separate paper discusses the performance of various instrumentation schemes, the environmental protection of these diagnostics under pressure, and the means by which data is extracted from a closed pressure system. In this paper, specific hydrostatic and dynamic pressure tests are used to demonstrate how these techniques are employed, the problems encountered, and the importance of the data obtained. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016MsT.........21G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016MsT.........21G">An improved sample loading technique for cellular metabolic response monitoring under pressure</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Gikunda, Millicent Nkirote To monitor cellular metabolism under pressure, a pressure chamber designed around a simple-to-construct capillary-based spectroscopic chamber coupled to a microliter-flow perfusion system is used in the laboratory. Although cyanide-induced metabolic responses from Saccharomyces cerevisiae (baker's yeast) could be controllably induced and monitored under pressure, previously used sample loading technique was not well controlled. An improved cell-loading technique which is based on use of a secondary inner capillary into which the sample is loaded then inserted into the capillary pressure chamber, has been developed. As validation, we demonstrate the ability to measure the chemically-induced metabolic responses at pressures of up to 500 bars. This technique is shown to be less prone to sample loss due to perfusive flow than the previous techniques used. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3038680','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3038680">Household responsibilities, income, and ambulatory blood pressure among working men and women</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Thurston, Rebecca C.; Sherwood, Andrew; Matthews, Karen A.; Blumenthal, James A. 2011-01-01 Objective To test the hypothesis that a greater perceived responsibility for household tasks and a greater number of hours spent doing these tasks would be associated with elevated ambulatory systolic (SBP) and diastolic blood pressure (DBP). The connection between job characteristics and cardiovascular outcomes has been widely studied. However, less is known about links between household work characteristics and cardiovascular health. Methods 113 employed unmedicated hypertensive men and women underwent one day of ambulatory blood pressure (ABP) monitoring. Participants provided information on 1) the number of hours spent doing and 2) their degree of responsibility for seven household tasks (child care, pet care, caring for ill/elderly, household chores, house/car repair, yardwork, finances). Associations between task hours and responsibility ratings in relation to SBP and DBP were estimated using generalized estimating equations, with covariates age, race, gender, body mass index, location, posture. Interactions with gender and socioeconomic position were assessed. Results A greater perceived responsibility for household tasks, but not the hours spent doing these tasks, was associated with higher ambulatory SBP (b(95% confidence interval (CI))=0.93(0.29–1.56), p=0.004) and DBP (b(95%CI)=0.30(0.10–0.51), p=0.003)). Significant interactions with income indicated that associations between household responsibilities and ABP were most pronounced among low income participants (SBP: b(95%CI)=1.40(0.58–2.21), p<0.001; DBP: b(95%CI)=0.48(0.18–0.78), p<0.01). The task most strongly associated with BP was household chores. No interactions with gender were observed. Conclusions Greater perceived responsibility for household tasks was associated with elevated ABP, particularly for lower income participants. Household obligations may have important implications for cardiovascular health, meriting further empirical attention. PMID:21217097 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29698498','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29698498">Psychophysiological responses of junior orienteers under competitive pressure.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Robazza, Claudio; Izzicupo, Pascal; D'Amico, Maria Angela; Ghinassi, Barbara; Crippa, Maria Chiara; Di Cecco, Vincenzo; Ruiz, Montse C; Bortoli, Laura; Di Baldassarre, Angela 2018-01-01 The purpose of the study was to examine psychobiosocial states, cognitive functions, endocrine responses (i.e., salivary cortisol and chromogranin A), and performance under competitive pressure in orienteering athletes. The study was grounded in the individual zones of optimal functioning (IZOF) and biopsychosocial models. Fourteen junior orienteering athletes (7 girls and 7 boys), ranging in age from 15 to 20 years (M = 16.93, SD = 1.77) took part in a two-day competitive event. To enhance competitive pressure, emphasis was placed on the importance of the competition and race outcome. Psychophysiological and performance data were collected at several points before, during, and after the races. Results showed that an increase in cortisol levels was associated with competitive pressure and reflected in higher perceived exertion (day 1, r = .32; day 2, r = .46), higher intensity of dysfunctional states (day 1, r = .59; day 2, r = .55), lower intensity of functional states (day 1, r = -.36; day 2, r = -.33), and decay in memory (day 1, r = -.27; day 2, r = -.35), visual attention (day 1, r = -.56; day 2, r = -.35), and attention/mental flexibility (day 1, r = .16; day 2, r = .26) tasks. The second day we observed better performance times, lower intensity of dysfunctional states, lower cortisol levels, improved visual attention and attention/mental flexibility (p < .050). Across the two competition days, chromogranin A levels were higher (p < .050) on the most difficult loops of the race in terms of both physical and psychological demands. Findings suggest emotional, cognitive, psychophysiological, and performance variables to be related and to jointly change across different levels of cognitive and physical load. Overall results are discussed in light of the IZOF and biopsychosocial models. The procedure adopted in the study also supports the feasibility of including additional cognitive load for possible practical applications. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5919653','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5919653">Psychophysiological responses of junior orienteers under competitive pressure</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Izzicupo, Pascal; D’Amico, Maria Angela; Ghinassi, Barbara; Crippa, Maria Chiara; Di Cecco, Vincenzo; Ruiz, Montse C.; Bortoli, Laura; Di Baldassarre, Angela 2018-01-01 The purpose of the study was to examine psychobiosocial states, cognitive functions, endocrine responses (i.e., salivary cortisol and chromogranin A), and performance under competitive pressure in orienteering athletes. The study was grounded in the individual zones of optimal functioning (IZOF) and biopsychosocial models. Fourteen junior orienteering athletes (7 girls and 7 boys), ranging in age from 15 to 20 years (M = 16.93, SD = 1.77) took part in a two-day competitive event. To enhance competitive pressure, emphasis was placed on the importance of the competition and race outcome. Psychophysiological and performance data were collected at several points before, during, and after the races. Results showed that an increase in cortisol levels was associated with competitive pressure and reflected in higher perceived exertion (day 1, r = .32; day 2, r = .46), higher intensity of dysfunctional states (day 1, r = .59; day 2, r = .55), lower intensity of functional states (day 1, r = -.36; day 2, r = -.33), and decay in memory (day 1, r = -.27; day 2, r = -.35), visual attention (day 1, r = -.56; day 2, r = -.35), and attention/mental flexibility (day 1, r = .16; day 2, r = .26) tasks. The second day we observed better performance times, lower intensity of dysfunctional states, lower cortisol levels, improved visual attention and attention/mental flexibility (p < .050). Across the two competition days, chromogranin A levels were higher (p < .050) on the most difficult loops of the race in terms of both physical and psychological demands. Findings suggest emotional, cognitive, psychophysiological, and performance variables to be related and to jointly change across different levels of cognitive and physical load. Overall results are discussed in light of the IZOF and biopsychosocial models. The procedure adopted in the study also supports the feasibility of including additional cognitive load for possible practical applications. PMID:29698498 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22745649','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22745649">A recurrence network approach for the analysis of skin blood flow dynamics in response to loading pressure.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Liao, Fuyuan; Jan, Yih-Kuen 2012-06-01 This paper presents a recurrence network approach for the analysis of skin blood flow dynamics in response to loading pressure. Recurrence is a fundamental property of many dynamical systems, which can be explored in phase spaces constructed from observational time series. A visualization tool of recurrence analysis called recurrence plot (RP) has been proved to be highly effective to detect transitions in the dynamics of the system. However, it was found that delay embedding can produce spurious structures in RPs. Network-based concepts have been applied for the analysis of nonlinear time series recently. We demonstrate that time series with different types of dynamics exhibit distinct global clustering coefficients and distributions of local clustering coefficients and that the global clustering coefficient is robust to the embedding parameters. We applied the approach to study skin blood flow oscillations (BFO) response to loading pressure. The results showed that global clustering coefficients of BFO significantly decreased in response to loading pressure (p<0.01). Moreover, surrogate tests indicated that such a decrease was associated with a loss of nonlinearity of BFO. Our results suggest that the recurrence network approach can practically quantify the nonlinear dynamics of BFO. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20233378','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20233378">High hydrostatic pressure and the cell membrane: stress response of Saccharomyces cerevisiae.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Bravim, Fernanda; de Freitas, Jéssica M; Fernandes, A Alberto R; Fernandes, Patricia M B 2010-02-01 The brewing and baking yeast Saccharomyces cerevisiae is a useful eukaryotic model of stress response systems whose study could lead to the understanding of stress response mechanisms in other organisms. High hydrostatic pressure (HHP) exerts broad effects upon yeast cells, interfering with cell membranes, cellular architecture, and the processes of polymerization and denaturation of proteins. In this review, we focus on the effect of HHP on the S. cerevisiae cell membrane and describe the main signaling pathways involved in the pressure response. </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_3");'>3</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li class="active">5</li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_6" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li class="active">6</li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="101"> <li> <a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19830025699','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19830025699">Time-dependent response of filamentary composite spherical pressure vessels</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Dozier, J. D. 1983-01-01 A filamentary composite spherical pressure vessel is modeled as a pseudoisotropic (or transversely isotropic) composite shell, with the effects of the liner and fill tubes omitted. Equations of elasticity, macromechanical and micromechanical formulations, and laminate properties are derived for the application of an internally pressured spherical composite vessel. Viscoelastic properties for the composite matrix are used to characterize time-dependent behavior. Using the maximum strain theory of failure, burst pressure and critical strain equations are formulated, solved in the Laplace domain with an associated elastic solution, and inverted back into the time domain using the method of collocation. Viscoelastic properties of HBFR-55 resin are experimentally determined and a Kevlar/HBFR-55 system is evaluated with a FORTRAN program. The computed reduction in burst pressure with respect to time indicates that the analysis employed may be used to predict the time-dependent response of a filamentary composite spherical pressure vessel. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26378750','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26378750">[Sulphureous mud-bath therapy and changes in blood pressure: observational investigation].</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Costantino, M; Marongiu, M B; Russomanno, G; Conti, V; Manzo, V; Filippelli, A 2015-01-01 The chronic arthropathies currently appear to be a major cause of disability with a negative impact on quality of life and health care spending. The mud-bath therapy is a spa treatment that induces benefic effects in chronic rheumatic diseases. It has long been debated on the assumption that the mud-bath spa therapy could have adverse cardiovascular effects which often induce caution and even a contraindication to the use of this treatment in chronic arthropathies associated with cardiovascular alterations such as hypertension. The aim of this observational study was to investigate, in arthrorheumatic subjects, the effects of sulphureous mud-bath cycle on blood pressure and the possible appearance of adverse drug reaction. 169 patients, with age range 42-86 years, suffering by chronic arthropathies were treated with sulphureous mud-bath therapy for 2 weeks. According to the arterial pressure values, measured before the spa treatment, the patients considered were divided in three groups: with normal blood pressure (NOR group); with high blood pressure, after, the latter group was divided in IPET (patients in treatment with antihypertensive drugs) and IPENT (patients not in antihypertensive therapy). The arterial pressure values, maximum and minimum, expressed in mmHg, were detected in the first (T1) - sixth (T6) and twelfth (T12) day of spa treatment. The media arterial pressure values collected before and after T1, before and after T6, before and after T12 , before T1 and after T12 were compared. The data, presented as mean±SD, were compared with the paired Student t test. A p value ≤0.05 was considered significant. The comparison between the mean values detected in pre and post T1, pre and post T6, pre and post T12 have showed that sulphureous mud-bath therapy induced a significant (p<0.05) reduction of arterial blood pressure values in patients suffering of chronic arthropathies with high blood pressure in antihypertensive therapy or not (IPET and IPENT groups </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3547172','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3547172">The effects of altered intrathoracic pressure on resting cerebral blood flow and its response to visual stimulation</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Hayen, Anja; Herigstad, Mari; Kelly, Michael; Okell, Thomas W.; Murphy, Kevin; Wise, Richard G.; Pattinson, Kyle T.S. 2013-01-01 Investigating how intrathoracic pressure changes affect cerebral blood flow (CBF) is important for a clear interpretation of neuroimaging data in patients with abnormal respiratory physiology, intensive care patients receiving mechanical ventilation and in research paradigms that manipulate intrathoracic pressure. Here, we investigated the effect of experimentally increased and decreased intrathoracic pressures upon CBF and the stimulus-evoked CBF response to visual stimulation. Twenty healthy volunteers received intermittent inspiratory and expiratory loads (plus or minus 9 cmH2O for 270 s) and viewed an intermittent 2 Hz flashing checkerboard, while maintaining stable end-tidal CO2. CBF was recorded with transcranial Doppler sonography (TCD) and whole-brain pseudo-continuous arterial spin labeling magnetic resonance imaging (PCASL MRI). Application of inspiratory loading (negative intrathoracic pressure) showed an increase in TCD-measured CBF of 4% and a PCASL-measured increase in grey matter CBF of 5%, but did not alter mean arterial pressure (MAP). Expiratory loading (positive intrathoracic pressure) did not alter CBF, while MAP increased by 3%. Neither loading condition altered the perfusion response to visual stimulation in the primary visual cortex. In both loading conditions localized CBF increases were observed in the somatosensory and motor cortices, and in the cerebellum. Altered intrathoracic pressures, whether induced experimentally, therapeutically or through a disease process, have possible significant effects on CBF and should be considered as a potential systematic confound in the interpretation of perfusion-based neuroimaging data. PMID:23108273 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19820034893&hterms=Hydrodynamic+Cavitation+Oil&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3DHydrodynamic%2BCavitation%2BOil','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19820034893&hterms=Hydrodynamic+Cavitation+Oil&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3DHydrodynamic%2BCavitation%2BOil">Observation of pressure variation in the cavitation region of submerged journal bearings</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Etsion, I.; Ludwig, L. P. 1981-01-01 Visual observations and pressure measurements in the cavitation zone of a submerged journal bearing are described. Tests are run at speeds of 1840 and 3000 rpm, and at each speed, four different levels of the ambient supply pressure are applied, ranging from 13.6 KPa to 54.4 KPa. A strong reverse flow is detected inside the cavitation area adjacent to its downstream end, and significant pressure variations on the order of 50 KPa are found inside the cavitation region at the downstream portion of its circumferential extent. Results indicate that the assumption of a constant cavitation pressure is incorrect in the case of enclosed cavitations, and it is postulated that oil which is saturated with air under atmospheric pressure becomes oversaturated in the subcavity pressure loop. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017EGUGA..19.6998W','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017EGUGA..19.6998W">Operational design and pressure response of large-scale compressed air energy storage in porous formations</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Wang, Bo; Bauer, Sebastian 2017-04-01 day. The average bottom hole pressure is 87 bars at the beginning of cyclic operation and reduces to 79 bars after 10 years. This pressure drop over time is caused by the open boundary conditions defined at the model edges and is not influenced by the cyclic operation. In the storage formation, the pressure response induced by the initial filling can be observed in the whole model domain, and a maximum pressure built-up of about 31 bars and 3 bars are observed near the wells and at a distance of 10 km from the wells, respectively. During the cyclic operation, however, pressure fluctuations of more than 1 bar can only be observed within the gas phase. Assuming formations with different permeabilities, a sensitivity analysis is carried out to find the number of wells required. Results show that the number of wells required does not linearly decrease with increasing permeability of the storage formation due to well interference during air extraction. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5974144','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5974144">Role of Coronary Myogenic Response in Pressure-Flow Autoregulation in Swine: A Meta-Analysis With Coronary Flow Modeling</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Dick, Gregory M.; Namani, Ravi; Patel, Bhavesh; Kassab, Ghassan S. 2018-01-01 Myogenic responses (pressure-dependent contractions) of coronary arterioles play a role in autoregulation (relatively constant flow vs. pressure). Publications on myogenic reactivity in swine coronaries vary in caliber, analysis, and degree of responsiveness. Further, data on myogenic responses and autoregulation in swine have not been completely compiled, compared, and modeled. Thus, it has been difficult to understand these physiological phenomena. Our purpose was to: (a) analyze myogenic data with standard criteria; (b) assign results to diameter categories defined by morphometry; and (c) use our novel multiscale flow model to determine the extent to which ex vivo myogenic reactivity can explain autoregulation in vivo. When myogenic responses from the literature are an input for our model, the predicted coronary autoregulation approaches in vivo observations. More complete and appropriate data are now available to investigate the regulation of coronary blood flow in swine, a highly relevant model for human physiology and disease. PMID:29875686 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28340147','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28340147">Evoked Pressure Pain Sensitivity Is Associated with Differential Analgesic Response to Verum and Sham Acupuncture in Fibromyalgia.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Zucker, Noah A; Tsodikov, Alex; Mist, Scott D; Cina, Stephen; Napadow, Vitaly; Harris, Richard E 2017-08-01 Fibromyalgia is a chronic pain condition with few effective treatments. Many fibromyalgia patients seek acupuncture for analgesia; however, its efficacy is limited and not fully understood. This may be due to heterogeneous pathologies among participants in acupuncture clinical trials. We hypothesized that pressure pain tenderness would differentially classify treatment response to verum and sham acupuncture in fibromyalgia patients. Baseline pressure pain sensitivity at the thumbnail at baseline was used in linear mixed models as a modifier of differential treatment response to sham versus verum acupuncture. Similarly, needle-induced sensation was also analyzed to determine its differential effect of treatment on clinical pain. A cohort of 114 fibromyalgia patients received baseline pressure pain testing and were randomized to either verum (N = 59) or sham (N = 55) acupuncture. Participants received treatments from once a week to three times a week, increasing in three-week blocks for a total of 18 treatments. Clinical pain was measured on a 101-point visual analog scale, and needle sensation was measured by questionnaire throughout the trial. Participants who had higher pain pressure thresholds had greater reduction in clinical pain following verum acupuncture while participants who had lower pain pressure thresholds showed better analgesic response to sham acupuncture. Moreover, patients with lower pressure pain thresholds had exacerbated clinical pain following verum acupuncture. Similar relationships were observed for sensitivity to acupuncture needling. These findings suggest that acupuncture efficacy in fibromyalgia may be underestimated and a more personalized treatment for fibromyalgia may also be possible. © 2017 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com </li> <li> <a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20130013479','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20130013479">PRSEUS Pressure Cube Test Data and Response</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Lovejoy, Andrew E. 2013-01-01 NASA s Environmentally Responsible Aviation (ERA) Program is examining the hybrid wing body (HWB) aircraft, among others, in an effort to increase the fuel efficiency of commercial aircraft. The HWB design combines features of a flying wing with features of conventional transport aircraft, and has the advantage of simultaneously increasing both fuel efficiency and payload. Recent years have seen an increased focus on the structural performance of the HWB. The key structural challenge of a HWB airframe is the ability to create a cost and weight efficient, non-circular, pressurized shell. Conventional round fuselage sections react cabin pressure by hoop tension. However, the structural configuration of the HWB subjects the majority of the structural panels to bi-axial, in-plane loads in addition to the internal cabin pressure, which requires more thorough examination and analysis than conventional transport aircraft components having traditional and less complex load paths. To address this issue, while keeping structural weights low, extensive use of advanced composite materials is made. This report presents the test data and preliminary conclusions for a pressurized cube test article that utilizes Boeing's Pultruded Rod Stitched Efficient Unitized Structure (PRSEUS), and which is part of the building block approach used for HWB development. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015JPhCS.659a2024H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015JPhCS.659a2024H">Exponential Boundary Observers for Pressurized Water Pipe</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Hermine Som, Idellette Judith; Cocquempot, Vincent; Aitouche, Abdel 2015-11-01 This paper deals with state estimation on a pressurized water pipe modeled by nonlinear coupled distributed hyperbolic equations for non-conservative laws with three known boundary measures. Our objective is to estimate the fourth boundary variable, which will be useful for leakage detection. Two approaches are studied. Firstly, the distributed hyperbolic equations are discretized through a finite-difference scheme. By using the Lipschitz property of the nonlinear term and a Lyapunov function, the exponential stability of the estimation error is proven by solving Linear Matrix Inequalities (LMIs). Secondly, the distributed hyperbolic system is preserved for state estimation. After state transformations, a Luenberger-like PDE boundary observer based on backstepping mathematical tools is proposed. An exponential Lyapunov function is used to prove the stability of the resulted estimation error. The performance of the two observers are shown on a water pipe prototype simulated example. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1334282','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1334282">Raw Pressure Data from Observation Wells at Brady's Hot Springs</a> <a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a> David Lim This .csv files contain the raw water pressure data from three observation wells during pumping tests performed in the Spring of 2016. Included is a "read me" file explaining the details of where and how the data were collected. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26695136','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26695136">Graphene Squeeze-Film Pressure Sensors.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Dolleman, Robin J; Davidovikj, Dejan; Cartamil-Bueno, Santiago J; van der Zant, Herre S J; Steeneken, Peter G 2016-01-13 The operating principle of squeeze-film pressure sensors is based on the pressure dependence of a membrane's resonance frequency, caused by the compression of the surrounding gas which changes the resonator stiffness. To realize such sensors, not only strong and flexible membranes are required, but also minimization of the membrane's mass is essential to maximize responsivity. Here, we demonstrate the use of a few-layer graphene membrane as a squeeze-film pressure sensor. A clear pressure dependence of the membrane's resonant frequency is observed, with a frequency shift of 4 MHz between 8 and 1000 mbar. The sensor shows a reproducible response and no hysteresis. The measured responsivity of the device is 9000 Hz/mbar, which is a factor 45 higher than state-of-the-art MEMS-based squeeze-film pressure sensors while using a 25 times smaller membrane area. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4490579','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4490579">Reconfigurable photonic crystals enabled by pressure-responsive shape-memory polymers</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Fang, Yin; Ni, Yongliang; Leo, Sin-Yen; Taylor, Curtis; Basile, Vito; Jiang, Peng 2015-01-01 Smart shape-memory polymers can memorize and recover their permanent shape in response to an external stimulus (for example, heat). They have been extensively exploited for a wide spectrum of applications ranging from biomedical devices to aerospace morphing structures. However, most of the existing shape-memory polymers are thermoresponsive and their performance is hindered by heat-demanding programming and recovery steps. Although pressure is an easily adjustable process variable such as temperature, pressure-responsive shape-memory polymers are largely unexplored. Here we report a series of shape-memory polymers that enable unusual ‘cold' programming and instantaneous shape recovery triggered by applying a contact pressure at ambient conditions. Moreover, the interdisciplinary integration of scientific principles drawn from two disparate fields—the fast-growing photonic crystal and shape-memory polymer technologies—enables fabrication of reconfigurable photonic crystals and simultaneously provides a simple and sensitive optical technique for investigating the intriguing shape-memory effects at nanoscale. PMID:26074349 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4153122','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4153122">CPAP Pressure for Prediction of Oral Appliance Treatment Response in Obstructive Sleep Apnea</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Sutherland, Kate; Phillips, Craig L.; Davies, Amanda; Srinivasan, Vasanth K.; Dalci, Oyku; Yee, Brendon J.; Darendeliler, M. Ali; Grunstein, Ronald R.; Cistulli, Peter A. 2014-01-01 Study Objectives: Mandibular advancement splints (MAS) are often preferred to CPAP treatment for OSA but are not always equally efficacious. High therapeutic CPAP pressure has been associated with MAS treatment failure in a Japanese population. We sought to assess the relationship between CPAP pressure and MAS treatment response in an Australian population. Methods: Therapeutic CPAP pressure and MAS treatment response were obtained from a one-month crossover trial of both treatments. Predictive utility of CPAP pressure to identify MAS treatment response was assessed. Results: Seventy-eight OSA patients were included (age 49.3 ± 11.1 years, BMI 29.1 ± 5.8 kg/m2) with predominantly moderate-severe OSA (AHI 30.0 ± 12.7/h). CPAP pressure was lower in MAS responders (MAS AHI < 10/h) 9.7 ± 1.6 vs. 11.7 ± 2.4 cm H O, p < 0.01, with area under ROC curve of 0.74 (95% CI 0.63-0.86), p < 0.01. The best cutoff value of 10.5 cm H O useful for discriminating MAS responders and non-responders in the previous Japanese population, was inadequate for prediction in the current population (0.47 negative predictive value [NPV]). However a cutoff of 13 cm H O identified MAS non-responders (1.0 NPV). Multivariate regression identified CPAP pressure (odds ratio [95% confidence interval] 0.53 [0.33-0.87], age (0.93 [0.87-0.99]) and AHI (0.92 [0.86-0.97]) as predictors of MAS treatment response (model r2 = 0.54, p < 0.001). Conclusions: In Australian patients, the majority of whom are Caucasian, a higher therapeutic CPAP pressure requirement in conjunction with age and OSA severity characteristics may be useful to indicate likelihood of success with MAS as an alternative therapy. Citation: Sutherland K, Phillips CL, Davies A, Srinivasan VK, Dalci O, Yee BJ, Darendeliler MA, Grunstein RR, Cistulli PA. CPAP pressure for prediction of oral appliance treatment response in obstructive sleep apnea. J Clin Sleep Med 2014;10(9):943-949. PMID:25142773 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3922657','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3922657">Baseline pressure errors (BPEs) extensively influence intracranial pressure scores: results of a prospective observational study</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> 2014-01-01 Background Monitoring of intracranial pressure (ICP) is a cornerstone in the surveillance of neurosurgical patients. The ICP is measured against a baseline pressure (i.e. zero - or reference pressure). We have previously reported that baseline pressure errors (BPEs), manifested as spontaneous shift or drifts in baseline pressure, cause erroneous readings of mean ICP in individual patients. The objective of this study was to monitor the frequency and severity of BPEs. To this end, we performed a prospective, observational study monitoring the ICP from two separate ICP sensors (Sensors 1 and 2) placed in close proximity in the brain. We characterized BPEs as differences in mean ICP despite near to identical ICP waveform in Sensors 1 and 2. Methods The study enrolled patients with aneurysmal subarachnoid hemorrhage in need of continuous ICP monitoring as part of their intensive care management. The two sensors were placed close to each other in the brain parenchyma via the same burr hole. The monitoring was performed as long as needed from a clinical perspective and the ICP recordings were stored digitally for analysis. For every patient the mean ICP as well as the various ICP wave parameters of the two sensors were compared. Results Sixteen patients were monitored median 164 hours (ranges 70 – 364 hours). Major BPEs, as defined by marked differences in mean ICP despite similar ICP waveform, were seen in 9 of them (56%). The BPEs were of magnitudes that had the potential to alter patient management. Conclusions Baseline Pressure Errors (BPEs) occur in a significant number of patients undergoing continuous ICP monitoring and they may alter patient management. The current practice of measuring ICP against a baseline pressure does not comply with the concept of State of the Art. Monitoring of the ICP waves ought to become the new State of the Art as they are not influenced by BPEs. PMID:24472296 </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1994CmpSt..28..255S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1994CmpSt..28..255S">Observations of a pressurized hydraulic hose under lateral liquid impacts</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Stewart, C. D.; Gorman, D. G. The effects of 'pin-hole' failure of one pressurized hydraulic hose on its neighbour are investigated. A pressurized test hose was inserted into a custom testing apparatus and subjected to a series of ten short duration liquid impacts simulating the pin-hole failure of an initial hose. Subsequent displacements of the hose were filmed and plotted with respect to time. Three distinct pattern groups emerged which were used to explain the resultant damage to the hose. It was observed that the middle pattern, corresponding to impacts 6 and 7, appears to be the point where the very damaging hydraulic penetration mechanism became dominant and the outer layer of the hose failed. On completion of the ten impact series it was observed that a small hole on the outer surface of the hose gave way to a relatively large damaged area in the strength bearing inner braid material. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AGUFM.C51B0970C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AGUFM.C51B0970C">Ocean Wave-to-Ice Energy Transfer Determined from Seafloor Pressure and Ice Shelf Seismic Observations</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Chen, Z.; Bromirski, P. D.; Gerstoft, P.; Stephen, R. A.; Wiens, D.; Aster, R. C.; Nyblade, A. 2017-12-01 Ice shelves play an important role in buttressing land ice from reaching the sea, thus restraining the rate of sea level rise. Long-period gravity wave impacts excite vibrations in ice shelves that may trigger tabular iceberg calving and/or ice shelf collapse events. Three kinds of seismic plate waves were continuously observed by broadband seismic arrays on the Ross Ice Shelf (RIS) and on the Pine Island Glacier (PIG) ice shelf: (1) flexural-gravity waves, (2) flexural waves, and (3) extensional Lamb waves, suggesting that all West Antarctic ice shelves are subjected to similar gravity wave excitation. Ocean gravity wave heights were estimated from pressure perturbations recorded by an ocean bottom differential pressure gauge at the RIS front, water depth 741 m, about 8 km north of an on-ice seismic station that is 2 km from the shelf front. Combining the plate wave spectrum, the frequency-dependent energy transmission and reflection at the ice-water interface were determined. In addition, Young's modulus and Poisson's ratio of the RIS are estimated from the plate wave motions, and compared with the widely used values. Quantifying these ice shelf parameters from observations will improve modeling of ice shelf response to ocean forcing, and ice shelf evolution. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19880033624&hterms=fitness&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3Dfitness','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19880033624&hterms=fitness&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3Dfitness">Aerobic fitness in women and responses to lower body negative pressure</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Frey, Mary Anne Bassett; Mathes, Karen L.; Hoffler, G. Wyckliffe 1987-01-01 The role of tolerance to orthostatic stress in the maintenance of high aerobic fitness in women was investigated by examining the responses of heart rate, stroke volume, cardiac output, Heather index of contractility, arterial pressure, peripheral resistance, change in calf circumference, and thoracic impedance of healthy female subjects to lower body negative pressure (LBNP) applied for 5 min at -50 mm Hg or until a subject became presyncopal. The testing protocol involved a stepwise reduction in pressure and consisted of two parts: an LBNP test in supine position followed by a treadmill test to peak aerobic capacity. Women were found to exhibit the same response pattern to LBNP as was previously reported by Convertino et al. (1984) for men. The results do not support the hypothesis that orthostatic tolerance in women is inversely related to aerobic fitness, as demonstrated by a finding that the peak aerobic capacity of subjects who became presyncopal did not differ from the peak of the tolerant subjects, and that hemodynamic responses to LBNPL were not a function of aerobic capacity. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19930036960&hterms=vertical+height&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D70%26Ntt%3Dvertical%2Bheight','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19930036960&hterms=vertical+height&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D70%26Ntt%3Dvertical%2Bheight">Observations of height-dependent pressure-perturbation structure of a strong mesoscale gravity wave</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Starr, David O'C.; Korb, C. L.; Schwemmer, Geary K.; Weng, Chi Y. 1992-01-01 Airborne observations using a downward-looking, dual-frequency, near-infrared, differential absorption lidar system provide the first measurements of the height-dependent pressure-perturbation field associated with a strong mesoscale gravity wave. A pressure-perturbation amplitude of 3.5 mb was measured within the lowest 1.6 km of the atmosphere over a 52-km flight line. Corresponding vertical displacements of 250-500 m were inferred from lidar-observed displacement of aerosol layers. Accounting for probable wave orientation, a horizontal wavelength of about 40 km was estimated. Satellite observations reveal wave structure of a comparable scale in concurrent cirrus cloud fields over an extended area. Smaller-scale waves were also observed. Local meteorological soundings are analyzed to confirm the existence of a suitable wave duct. Potential wave-generation mechanisms are examined and discussed. The large pressure-perturbation wave is attributed to rapid amplification or possible wave breaking of a gravity wave as it propagated offshore and interacted with a very stable marine boundary layer capped by a strong shear layer. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4849866','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4849866">Short-Term Moderately Elevated Intraocular Pressure Is Associated With Elevated Scotopic Electroretinogram Responses</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Choh, Vivian; Gurdita, Akshay; Tan, Bingyao; Prasad, Ratna C.; Bizheva, Kostadinka; Joos, Karen M. 2016-01-01 Purpose Moderately elevated intraocular pressure (IOP) is a risk factor for open-angle glaucoma. Some patients suffer glaucoma despite clinically measured normal IOPs. Fluctuations in IOP may have a significant role since IOPs are higher during sleep and inversion activities. Controlled transient elevations of IOPs in rats over time lead to optic nerve structural changes that are similar to the early changes observed in constant chronic models of glaucoma. Because early intervention decreases glaucoma progression, this study was done to determine if early physiological changes to the retina could be detected with noninvasive electrophysiological and optical imaging tests during moderately elevated IOP. Methods Intraocular pressures were raised to moderately high levels (35 mm Hg) in one eye of Sprague-Dawley rats while the other (control) eye was untreated. One group of rats underwent scotopic threshold response (STR) and electroretinogram (ERG) testing, while another 3 groups underwent optical coherence tomography (OCT) imaging, Western blot, or histologic evaluation. Results The amplitudes of the STR and ERG responses in eyes with moderately elevated IOPs were enhanced compared to the values before IOP elevation, and compared to untreated contralateral eyes. Structural changes to the optic nerve also occurred during IOP elevation. Conclusions Although ischemic IOP elevations are well-known to globally reduce components of the scotopic ERG, acute elevation in rats to levels often observed in untreated glaucoma patients caused an increase in these parameters. Further exploration of these phenomena may be helpful in better understanding the mechanisms mediating early retinal changes during fluctuating or chronically elevated IOP. PMID:27100161 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26892713','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26892713">A prospective double-blinded randomized controlled trial comparing systemic stress response in Laparoascopic cholecystectomy between low-pressure and standard-pressure pneumoperitoneum.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Shoar, Saeed; Naderan, Mohammad; Ebrahimpour, Hossein; Soroush, Ahmadreza; Nasiri, Shirzad; Movafegh, Ali; Khorgami, Zhamak 2016-04-01 Laparoscopic cholecystectomy (LC) has become the gold-standard treatment for gallstone diseases. However, despite huge reduction in operative injury, systemic stress response remains high. This randomized controlled trial (RCT) aimed to compare systemic stress response between 2 different techniques of CO2 pneumoperitoneum. Trough a prospective, double-blinded RCT, serum levels of cortisol, adrenaline, glucose, and C-reactive protein (CRP) were compared between the two groups consisted of 50 patients undergoing LC under low-pressure and standard-pressure CO2 pneimoperitoneum. A total of fifty patients undergoing LC were equally assigned to 2 groups of twenty five patients. Average age was 48 ± 13.8 years (range, 19-74 years). Operative time was similar between standard-pressure group (47.8 ± 16.8 min) and low-pressure group (53.6 ± 25.1). Moreover, intra-operative IV volume administration and urine output did not differ significantly between the 2 groups (p > 0.05). Although the average heart rate and mean arterial pressure were slightly higher in a standard-pressure group compared with a low-pressure group, serial measurements of these parameters were statistically similar between the 2 groups. Serial changes of serum levels of cortisol, glucose, adrenaline, and CRP were compared between surgery day, postoperative 6-h and 1st postoperative day, which did not differ significantly between the standard-pressure and the low-pressure groups (p > 0.05). Our study did not reveal any alteration in systemic stress response with reduction in intra-abdominal pressure of pneumoperitoneum in LC. RCT REGISTRATION: irct.ir ID: IRCT201110072982N5. Copyright © 2016 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved. </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li class="active">6</li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_7" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li class="active">7</li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="121"> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1995737','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1995737">Regulation of Cell Cycle and Stress Responses to Hydrostatic Pressure in Fission Yeast</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> George, Vinoj T.; Brooks, Gavin 2007-01-01 We have investigated the cellular responses to hydrostatic pressure by using the fission yeast Schizosaccharomyces pombe as a model system. Exposure to sublethal levels of hydrostatic pressure resulted in G2 cell cycle delay. This delay resulted from Cdc2 tyrosine-15 (Y-15) phosphorylation, and it was abrogated by simultaneous disruption of the Cdc2 kinase regulators Cdc25 and Wee1. However, cell cycle delay was independent of the DNA damage, cytokinesis, and cell size checkpoints, suggesting a novel mechanism of Cdc2-Y15 phosphorylation in response to hydrostatic pressure. Spc1/Sty1 mitogen-activated protein (MAP) kinase, a conserved member of the eukaryotic stress-activated p38, mitogen-activated protein (MAP) kinase family, was rapidly activated after pressure stress, and it was required for cell cycle recovery under these conditions, in part through promoting polo kinase (Plo1) phosphorylation on serine 402. Moreover, the Spc1 MAP kinase pathway played a key role in maintaining cell viability under hydrostatic pressure stress through the bZip transcription factor, Atf1. Further analysis revealed that prestressing cells with heat increased barotolerance, suggesting adaptational cross-talk between these stress responses. These findings provide new insight into eukaryotic homeostasis after exposure to pressure stress. PMID:17699598 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2258208','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2258208">Heritability of Blood Pressure Responses to Dietary Sodium and Potassium Intake in Chinese Population</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Gu, Dongfeng; Rice, Treva; Wang, Shiping; Yang, Wenjie; Gu, Chi; Chen, Chung-Shiuan; Hixson, James E.; Jaquish, Cashell E.; Yao, Zhi-Jian; Liu, De-Pei; Rao, Dabeeru C.; He, Jiang 2008-01-01 The heritability of blood pressure responses to dietary intervention has not been well studied. We examined the heritability of blood pressure responses to dietary sodium and potassium intake in a family feeding-study among 1,906 study participants living in rural north China. The dietary intervention included a 7-day low sodium-feeding (51.3 mmol/day), a 7-day high sodium-feeding (307.8 mmol/day), and a 7-day high-sodium plus potassium-supplementation (60 mmol/day). Blood pressure was measured 9 times during the 3-day baseline period preceding the intervention and also during the last 3 days of each intervention phase using a random-zero sphygmomanometer. Heritability was computed using maximum likelihood methods under a variance components model as implemented in the computer program SOLAR. The heritabilities of baseline blood pressure were 0.31 for systolic, 0.32 for diastolic, and 0.34 for mean arterial pressure. The heritabilities increased significantly under dietary intervention and were 0.49, 0.49, and 0.51 during low-sodium, 0.47, 0.49, and 0.51 during high-sodium, and 0.51, 0.52, and 0.53 during potassium-supplementation for systolic, diastolic, and mean arterial pressure, respectively. The heritabilities for percentage blood pressure responses to low-sodium were 0.20, 0.21 and 0.23, to high-sodium were 0.22, 0.33, and 0.33, and to potassium-supplementation were 0.24, 0.21, and 0.25, for systolic, diastolic, and mean arterial pressure, respectively. Our study indicated that the heritabilities of blood pressure under controlled dietary sodium and potassium intake were significantly higher than those under usual diet. In addition, the heritabilities of blood pressure responses to dietary sodium and potassium intake were moderate in this study population. PMID:17485599 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1363925','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1363925">Reservoir response to thermal and high-pressure well stimulation efforts at Raft River, Idaho</a> <a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a> Plummer, Mitchell; Bradford, Jacob; Moore, Joseph An injection stimulation test begun at the Raft River geothermal reservoir in June, 2013 has produced a wealth of data describing well and reservoir response via high-resolution temperature logging and distributed temperature sensing, seismic monitoring, periodic borehole televiewer logging, periodic stepped flow rate tests and tracer injections before and after stimulation efforts. One of the primary measures of response to the stimulation is the relationship between fluid pressure and flow rate, short-term during forced flow rate changes and the long-term change in injectivity. In this paper we examine that hydraulic response using standard pumping test analysis methods, largely because pressuremore » response to the stimulation was not detected, or measurable, in other wells. Analysis of stepped rate flow tests supports the inference from other data that a large fracture, with a radial extent of one to several meters, intersects the well in the target reservoir, suggests that the flow regime is radial to a distance of only several meters and demonstrates that the pressure build-up cone reaches an effective constant head at that distance. The well’s longer term hydraulic response demonstrated continually increasing injectivity but at a dramatically faster rate later from ~2 years out and continuing to the present. The net change in injectivity is significantly greater than observed in other longterm injectivity monitoring studies, with an approximately 150–fold increase occurring over ~2.5 years. While gradually increasing injectivity is a likely consequence of slow migration of a cooling front, and consequent dilation of fractures, the steady, ongoing, rate of increase is contrary to what would be expected in a radial or linear flow regime, where the cooling front would slow with time. As a result, occasional step-like changes in injectivity, immediately following high-flow rate tests suggest that hydro shearing during high-pressure testing altered the </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017APS..DPPKI2003P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017APS..DPPKI2003P">Observation of a New High-Pressure Solid Phase in Dynamically Compressed Aluminum</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Polsin, D. N. 2017-10-01 Aluminum is ideal for testing theoretical first-principles calculations because of the relative simplicity of its atomic structure. Density functional theory (DFT) calculations predict that Al transforms from an ambient-pressure, face-centered-cubic (fcc) crystal to the hexagonal close-packed (hcp) and body-centered-cubic (bcc) structures as it is compressed. Laser-driven experiments performed at the University of Rochester's Laboratory for Laser Energetics and the National Ignition Facility (NIF) ramp compressed Al samples to pressures up to 540 GPa without melting. Nanosecond in-situ x-ray diffraction was used to directly measure the crystal structure at pressures where the solid-solid phase transformations of Al are predicted to occur. Laser velocimetry provided the pressure in the Al. Our results show clear evidence of the fcc-hcp and hpc-bcc transformations at 216 +/- 9 GPa and 321 +/- 12 GPa, respectively. This is the first experimental in-situ observation of the bcc phase in compressed Al and a confirmation of the fcc-hcp transition previously observed under static compression at 217 GPa. The observations indicate these solid-solid phase transitions occur on the order of tens of nanoseconds time scales. In the fcc-hcp transition we find the original texture of the sample is preserved; however, the hcp-bcc transition diminishes that texture producing a structure that is more polycrystalline. The importance of this dynamic is discussed. The NIF results are the first demonstration of x-ray diffraction measurements at two different pressures in a single laser shot. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1332311','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1332311">A field study of the ventilatory response to ambient temperature and pressure in sport diving.</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Muller, F L 1995-01-01 This study reports on the relationship between minute ventilation (VE) and environmental variables of temperature (T) and pressure (P) during open water diving. The author conducted a total of 38 dives involving either a light (20 dives) or a moderate (18 dives) level of physical activity. Within each of these groups, P and T taken together accounted for about two thirds of the variance in the VE data. A very significant increase in VE was observed as T decreased (1 < T(degrees C) < 22), and the magnitude of this increase at a given pressure level was similar in the 'light' and the 'moderate' data sets. A second order observation, particularly notable at lower temperature, was the decrease in VE with increasing pressure under conditions of light work. Empirical functions of the from VE = A+B/P n[1 + exp(T - 8)/10], where A, B, and n are adjustable variables, could accommodate both data sets over the whole range of T and P. These results are the first obtained under actual diving conditions to provide evidence for interactions between P, T, and VE. Understanding the physiological mechanisms by which these interactions occur would assist in appreciation of the limitations imposed on scuba divers by the environmental conditions as they affect their ventilatory responses. PMID:8800853 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23913461','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23913461">Prognostic value of renal fractional flow reserve in blood pressure response after renal artery stenting (PREFER study).</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Kądziela, Jacek; Januszewicz, Andrzej; Prejbisz, Aleksander; Michałowska, Ilona; Januszewicz, Magdalena; Florczak, Elżbieta; Kalińczuk, Łukasz; Norwa-Otto, Bożena; Warchoł, Ewa; Witkowski, Adam 2013-01-01 The aim of our study was to determine a potential relationship between resting translesional pressures ratio (Pd/Pa ratio), renal fractional flow reserve (rFFR) and blood pressure response after renal artery stenting. Thirty five hypertensive patients (49% males, mean age 64 years) with at least 60% stenosis in angiography, underwent renal artery stenting. Translesional systolic pressure gradient (TSPG), Pd/Pa ratio (the ratio of mean distal to lesion and mean proximal pressures) and hyperemic rFFR - after intrarenal administration of papaverine - were measured before stent implantation. Ambulatory blood pressure measurements (ABPM) were recorded before the procedure and after 6 months. The ABPM results were presented as blood pressure changes in subgroups of patients with normal (≥ 0.9) vs. abnormal (< 0.9) Pd/Pa ratio and normal (≥ 0.8) vs. abnormal (< 0.8) rFFR. Median Pd/Pa ratio was 0.84 (interquartile range 0.79-0.91) and strongly correlated with TSPG (r = -0.89, p < 0.001), minimal lumen diameter (MLD; r = 0.53, p < 0.005) and diameter stenosis (DS; r = -0.51, p < 0.005). Median rFFR was 0.78 (0.72-0.82). Similarly, significant correlation between rFFR and TSPG (r = -0.86, p < 0.0001), as well as with MLD (r = 0.50, p < 0.005) and DS (r = -0.51, p < 0.005) was observed. Procedural success was obtained in all patients. Baseline Pd/Pa ratio and rFFR did not predict hypertension response after renal artery stenting. Median changes of 24-h systolic/diastolic blood pressure were comparable in patients with abnormal vs. normal Pd/Pa ratio (-4/-3 vs. 0/2 mm Hg; p = NS) and with abnormal vs. normal rFFR (-2/-1 vs. -2/-0.5 mm Hg, respectively). Physiological assessment of renal artery stenosis using Pd/Pa ratio and papaverine- induced renal fractional fl ow reserve did not predict hypertension response after renal artery stenting. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=52287','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=52287">Tension responses to rapid pressure release in glycerinated rabbit muscle fibers.</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Fortune, N S; Geeves, M A; Ranatunga, K W 1991-01-01 We have previously shown that the isometric tension of a fully calcium-activated skinned rabbit psoas muscle fiber is reversibly depressed by increased hydrostatic pressure. We report here the characterization of tension transients induced by a rapid (less than 1-ms) release of increased pressure at 12 degrees C. The tension transient consists of three clear phases, an initial further decrease of tension in phase with pressure change followed by two phases of tension increase back to the level recorded at ambient pressure. The mean reciprocal relaxation time for phase 2 (1/tau 2) was approximately 17 s-1 and that for phase 3 (1/tau 3) was 3 s-1. The presence of 20 mM inorganic phosphate markedly increased 1/tau 2 to approximately 52 s-1 and decreased 1/tau 3 to approximately 1.7 s-1. These observations are interpreted in terms of a pressure-sensitive transition between two attached crossbridge states of low (or zero) and higher force. This is compatible with the pressure-sensitive isomerization of actomyosin previously observed in solution. The results presented allow us to propose a coupling between a specific pressure-sensitive isomerization of purified actomyosin, the phosphate release step of the ATPase pathway, and the force-generating event of the cross-bridge cycle. PMID:1871140 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3166530','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3166530">Attenuation of Exaggerated Exercise Blood Pressure Response in African-American Women by Regular Aerobic Physical Activity</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Bond, Vernon; Millis, Richard M.; Adams, R. George; Oke, Luc M.; Enweze, Larry; Blakely, Raymond; Banks, Marshall; Thompson, Terry; Obisesan, Thomas; Sween, Jennifer C. 2011-01-01 Introduction A hyperreactive blood pressure response to exercise is a predictor of developing hypertension. The present study determined the influence of physical activity on an exaggerated exercise blood pressure response (EEBPR) in normotensive African-American women. Methods We screened 36 women 18–26 years of age for EEBPR defined as a ≥50 mm Hg difference in systolic blood pressure at rest and during exercise at 50% peak oxygen uptake (VO2peak). Seven subjects demonstrated an EEBPR and participated in the study. Study participants trained for eight weeks on a bicycle ergometer at a work intensity of 70% VO2peak. Blood pressure, heart rate, cardiac output (CO), stroke volume (SV), and total peripheral vascular resistance (TPR) were determined at baseline and during submaximal exercise at power outputs of 30 W and 50% VO2peak. Subjects served as their own controls, and data were evaluated by using a paired t test at P<.05. Results Effectiveness of the intervention was shown by a significantly greater VO2peak associated with significant decrements in systolic and mean arterial pressures at power outputs of 30 W and 50% VO2peak. A significant decrement in heart rate was observed during exercise at 30 W. Significant increments in CO and SV and decrement in TPR were found during exercise at 50% VO2peak. Conclusion The reduction in TPR associated with regular aerobic physical activity may attenuate the EEBPR and decrease the risk for hypertension in normotensive, young-adult, African-American women. PMID:16315376 </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2011AGUFM.S41E..01A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2011AGUFM.S41E..01A">Discriminating different type waves from pressure and ground motion observation in the seafloor by DONET cabled observation network.</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Araki, E.; Kawaguchi, K.; Kaneda, Y. 2011-12-01 We developed and deployed seafloor cabled observatory called "Dense Ocean-floor Network for Earthquake and Tsunamis (DONET)" in the Nankai Trough, south of Japan. The main purpose of the DONET network is to observe large earthquake such as Tonankai earthquake in the deployed seafloor and associate Tsunamis in real-time to help disaster mitigation, and as well to monitor inter-seismic crustal activities such as micro earthquakes, very low frequency earthquakes, and slower crustal deformation. In each DONET seafloor observatory, high-sensitive broadband set of instruments for seismic and seafloor pressure monitoring, consisted from Guralp CMG3T broadband seismometer, Metrozet TSA100S accelerometer, Paroscientific 8B7000-2 pressure gauge, a deep-sea differential pressure gauge, a hydrophone, and a seawater thermometer, are installed. The density of seafloor observatories are 20 observatories distributed in 15-30 km interval which is optimized for monitoring of events in the plate boundary beneath the network. DONET may be regarded as a large-scale, high sensitive high density seismic array for monitoring teleseismic events in the Philippine Sea and the Pacific Ocean. The DONET seafloor observatories are situated in wide range of seafloor depth between 1800m and 4500m, from the seafloor basin about 50 km off Japanese Island through the slope of accerecionary prism to the deep trench axis 150 km off the coast, that may also regarded as a vertical array in the 4.5km thick ocean. This variation of depths helps identify T-phases from the array record. In data analysis, it is necessary to identify propagation mode of each observed wave which may often be mixed together. In our design of DONET observation system, we took care to help identification of seismic phase by obtaining both ground motion and seafloor pressure in the same location. This is simply achieved by combining seafloor pressure gauges and seismometer in a single observatory package, but care was taken to </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16024223','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16024223">Oxidative stress and acute-phase response in patients with pressure sores.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Cordeiro, Maria Bernarda Cavalcanti; Antonelli, Elida Juliana; da Cunha, Daniel Ferreira; Júnior, Alceu Afonso Jordão; Júnior, Virmondes Rodrigues; Vannucchi, Helio 2005-09-01 We investigated the relation between oxidative stress and the occurrence of the acute-phase response with serum ascorbic acid and alpha-tocopherol levels in patients with pressure sores. The following groups of patients were studied: 1) those who had patients with pressure sores, 2) those who had pneumonia, and 3) those who did not develop pressure sores or any type of infection (control). Concentrations of total proteins, albumin, creatinine, iron, ferritin, transferrin, C-reactive protein, alpha1-acid glycoprotein, total iron-binding capacity, ascorbic acid, alpha-tocopherol, and malondialdehyde were measured during the first days of hospitalization. Albumin concentrations were significantly lower (P < 0.05) and C-reactive protein concentrations were significantly higher (P < 0.05) in patients with pressure sores compared with controls. Concentrations of ascorbic acid and alpha-tocopherol were significantly decreased (P < 0.05) in patients who had pressure sores or infection, whereas malondialdehyde concentrations were significantly increased (P < 0.05) compared with control patients. Five of 11 patients (55.56%) with pressure sores and 10 of 12 patients (83.33%) with pneumonia presented serum ascorbic acid concentrations below the reference value (34 to 91 micromol/L). Concentrations of ascorbic acid and alpha-tocopherol versus malondialdehyde were significantly correlated in the three patient groups (r = -0.44, P < 0.05; r = -0.55, P < 0.01, respectively). Patients with pressure sores and acute infection present a systemic inflammatory response accompanied by an increase in lipid peroxidation that is associated with decreased serum ascorbic acid and alpha-tocopherol levels, suggesting that these patients may be at risk for important nutritional deficiencies. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017EGUGA..1915734M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017EGUGA..1915734M">Investigation of the spatial variability and possible origins of wind-induced air pressure fluctuations responsible for pressure pumping</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Mohr, Manuel; Laemmel, Thomas; Maier, Martin; Zeeman, Matthias; Longdoz, Bernard; Schindler, Dirk 2017-04-01 The exchange of greenhouse gases between the soil and the atmosphere is highly relevant for the climate of the Earth. Recent research suggests that wind-induced air pressure fluctuations can alter the soil gas transport and therefore soil gas efflux significantly. Using a newly developed method, we measured soil gas transport in situ in a well aerated forest soil. Results from these measurements showed that the commonly used soil gas diffusion coefficient is enhanced up to 30% during periods of strong wind-induced air pressure fluctuations. The air pressure fluctuations above the forest floor are only induced at high above-canopy wind speeds (> 5 m s-1) and lie in the frequency range 0.01-0.1 Hz. Moreover, the amplitudes of air pressure fluctuations in this frequency range show a clear quadratic dependence on mean above-canopy wind speed. However, the origin of these wind-induced pressure fluctuations is still unclear. Airflow measurements and high-precision air pressure measurements were conducted at three different vegetation-covered sites (conifer forest, deciduous forest, grassland) to investigate the spatial variability of dominant air pressure fluctuations, their origin and vegetation-dependent characteristics. At the conifer forest site, a vertical profile of air pressure fluctuations was measured and an array consisting of five pressure sensors were installed at the forest floor. At the grassland site, the air pressure measurements were compared with wind observations made by ground-based LIDAR and spatial temperature observations from a fibre-optic sensing network (ScaleX Campaign 2016). Preliminary results show that at all sites the amplitudes of relevant air pressure fluctuations increase with increasing wind speed. Data from the array measurements reveal that there are no time lags between the air pressure signals of different heights, but a time lag existed between the air pressure signals of the sensors distributed laterally on the forest floor </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27757187','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27757187">Diagnostic Value of Electrocardiogram in Predicting Exaggerated Blood Pressure Response to Exercise Stress Testing.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Eshraghi, Ali; Ebdali, Reyhaneh Takalloo; Sajjadi, Seyed Sajed; Golnezhad, Reza 2016-08-01 It is believed that an exaggerated blood pressure response (EBPR) to exercise stress test is associated with a higher risk of cardiovascular events. It is also assumed that QT dispersion (QT-d), which was originally proposed to measure the spatial dispersion of ventricular recovery times, may have a relationship to cardiovascular events. The objective of this study was to examine the difference of changes in QT-d, Maxi-QT, Mini-QT, and QT-c (corrected QT interval) of the electrocardiogram in two groups of patients with exaggerated blood pressure responses (EBPR group) and normal responses (control group) to exercise testing. Also, the diagnostic value of each of these criteria in the prediction of EBPR was studied. This cross-sectional study was conducted from May 2015 to February 2016 on patients suspected of coronary artery disease (CAD) undergoing exercise testing who had been referred to Ghaem and Imam Reza hospitals in Mashhad (Iran). All patients underwent a treadmill exercise test with the 12-lead ECG, which was optically scanned and digitized for analysis of QT-d, QT max, and QT min. Patients were divided into two groups of normal and EBPR to exercise testing. QT changes of ECG were compared between the two groups, and the diagnostic accuracy of QT variables for prediction of EBPR to exercise testing was studied. A multiple linear regression analysis (MLR), Pearson Chi-qquare, independent samples t-test, and receiver operating characteristic (ROC) curve were used as statistical methods in IBM SPSS version 19. Sixty patients (55% male) with a mean age of 50.48 ± 10.89 years were studied in two groups of normal (n=30) and exaggerated blood pressure response (n=30) to exercise testing. Maximum QT and QT dispersion were statistically different in individuals' exaggerated blood pressure response to exercise stress test (p < 0.05). The logistic regression analysis revealed that none of our parameters predicted the EBPR. The ROC curve showed that 50 and 345 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28831570','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28831570">Differential Response Pattern of Oropharyngeal Pressure by Bolus and Dry Swallows.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Hasegawa, Mana; Kurose, Masayuki; Okamoto, Keiichiro; Yamada, Yoshiaki; Tsujimura, Takanori; Inoue, Makoto; Sato, Taisuke; Narumi, Takatsune; Fujii, Noritaka; Yamamura, Kensuke 2018-02-01 The aim of this study was to determine if bolus and dry swallow showed similar pressure changes in the oropharynx using our newly developed device. A unique character of it includes that baropressure can be measured with the sensor being placed in the balloon and can assess the swallowing mechanics in terms of pressure changes in the oropharynx with less influences of direct contacts of boluses and oropharyngeal structures during swallow indirectly. Fifteen healthy subjects swallowed saliva (dry), 15 ml of water, 45 ml of water, and 15 ml of two different types of food in terms of viscosity (potage soup-type and mayonnaise-type foods). Suprahyoid muscle activity was recorded simultaneously. Three parameters, area under the curve (AUC), peak amplitude, and duration of pressure, were analyzed from each swallow. Almost all of the bolus swallowing events had biphasic baropressure responses consisting of an early phase and late phase (99%), whereas 90% of the saliva swallowing events had a single phase. AUC, peak, and duration displayed greater effects during the late phase than during the early phase. Baropressure of the early phase, but not of the late phase, significantly increased with increasing volume; however, small but significant viscosity effects on pressure were seen during both phases. Peak pressure of the late phase was preceded by maximum muscle activity, whereas that of the early phase was seen when muscle activity displayed a peak response. These findings indicated that our device with the ability to measure baropressure has the potential to provide additional parameter to assess the swallow physiology, and biphasic baropressure responses in the early and late phases could reflect functional aspects of the swallowing reflexes. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018MSSP..106..249Z','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018MSSP..106..249Z">Clutch pressure estimation for a power-split hybrid transmission using nonlinear robust observer</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Zhou, Bin; Zhang, Jianwu; Gao, Ji; Yu, Haisheng; Liu, Dong 2018-06-01 For a power-split hybrid transmission, using the brake clutch to realize the transition from electric drive mode to hybrid drive mode is an available strategy. Since the pressure information of the brake clutch is essential for the mode transition control, this research designs a nonlinear robust reduced-order observer to estimate the brake clutch pressure. Model uncertainties or disturbances are considered as additional inputs, thus the observer is designed in order that the error dynamics is input-to-state stable. The nonlinear characteristics of the system are expressed as the lookup tables in the observer. Moreover, the gain matrix of the observer is solved by two optimization procedures under the constraints of the linear matrix inequalities. The proposed observer is validated by offline simulation and online test, the results have shown that the observer achieves significant performance during the mode transition, as the estimation error is within a reasonable range, more importantly, it is asymptotically stable. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21532036','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21532036">Electrical stimulation of acupuncture points and blood pressure responses to postural changes: a pilot study.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Jones, Alice Y M; Kwan, Y L; Leung, Nathan T F; Yu, Rachel P W; Wu, Cindy M Y; Warburton, Darren E R 2011-05-01 Application of transcutaneous electrical stimulation over acupuncture points (Acu-TENS) facilitates heart rate recovery after exercise and restores hemodynamic stability after open heart surgery. The role of Acu-TENS on cardiovascular parameters in response to postural changes has not been reported. To investigate (1) the effect of Acu-TENS on blood pressure responses to -10º head-down postural change and (2) whether such effects were associated with modulation by the autonomic nervous system. Sixteen healthy volunteers, mean age 22.8 (SD, 3.1) years, were subjected to a -10º head-down tilt from the supine position on 3 separate occasions and received in random order the following 3 intervention protocols for 40 minutes before the postural change: Acu-TENS (over bilateral acupuncture points, PC6), sham-TENS (TENS applied to the skin over the patellae), and control (no electrical output from the TENS device applied at PC6). Mean arterial pressure, large artery elasticity index, cardiac output, and heart rate were recorded and compared at different stimulation protocols in the supine and -10º head-down tilt positions. Spectral analysis of heart rate variability was used to determine any modulation by the autonomic nervous system. Change in large artery elasticity index was observed only in the Acu-TENS group (P < .05) and mean arterial pressure appeared most stable during Acu-TENS. Autonomic nervous system modulation was not apparent with spectral analysis, irrespective of intervention. Sympathetic activity predominated in all positions. Acu-TENS seems to reduce blood pressure changes with -10º head-down tilt with concomitant changes in arterial vessel tone. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/18331039','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/18331039">Pressure response of three-dimensional cyanide-bridged bimetallic magnets.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Ohba, Masaaki; Kaneko, Wakako; Kitagawa, Susumu; Maeda, Takuho; Mito, Masaki 2008-04-02 Effects of pressure on the structures and magnetic properties of three types of 3-D cyanide-bridged bimetallic coordination polymer magnets, MnIICrIII ferrimagnet [Mn(en)]3[Cr(CN)6]2.4H2O (1; en = ethylenediamine), NiIICrIII ferromagnet [Ni(dipn)]3[Cr(CN)6]2.3H2O (2; dipn = N,N-di(3-aminopropyl)amine), and NiIIFeIII ferromagnet [Ni(dipn)]2[Ni(dipn)(H2O)][Fe(CN)6]2.11H2O (3), were systematically examined under hydrostatic pressure up to 19.8 GPa using a piston-cylinder-type pressure cell and a diamond anvil cell. The ferrimagnet 1 showed the reversible crystalline-to-amorphous-like phase change, and the magnetic phase transition temperature (TC) was reversibly changed from 69 K at 0 GPa to 126 K at 4.7 GPa. At higher pressure, the net magnetization was suppressed with increasing pressure, and the magnetic state at 19.8 GPa was assumed to be paramagnetic. The initial ferrimagnetic phase of 1 was not recovered after releasing the pressure from 19.8 GPa. The magnetic phase of 2 was reversibly converted between ferromagnetic and paramagnetic-like phase in the range 0 </= P </= 4.7 GPa while maintaining its crystallinity. The porous ferromagnet 3 was easily amorphized and irreversibly lost the ferromagnetic phase under low pressure (P </= 1.0 GPa). The flexible cyanide-bridged magnetic frameworks demonstrate well the pressure response as a reflection of differences in the magnetic structure and the framework strength in the GPa range. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AGUFM.S51E..08B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AGUFM.S51E..08B">New Laboratory Observations of Thermal Pressurization Weakening</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Badt, N.; Tullis, T. E.; Hirth, G. 2017-12-01 Dynamic frictional weakening due to pore fluid thermal pressurization has been studied under elevated confining pressure in the laboratory, using a rotary-shear apparatus having a sample with independent pore pressure and confining pressure systems. Thermal pressurization is directly controlled by the permeability of the rocks, not only for the initiation of high-speed frictional weakening but also for a subsequent sequence of high-speed sliding events. First, the permeability is evaluated at different effective pressures using a method where the pore pressure drop and the flow-through rate are compared using Darcy's Law as well as a pore fluid oscillation method, the latter method also permitting measurement of the storage capacity. Then, the samples undergo a series of high-speed frictional sliding segments at a velocity of 2.5 mm/s, under an applied confining pressure and normal stress of 45 MPa and 50 MPa, respectively, and an initial pore pressure of 25 MPa. Finally the rock permeability and storage capacity are measured again to assess the evolution of the rock's pore fluid properties. For samples with a permeability of 10-20 m2 thermal pressurization promotes a 40% decrease in strength. However, after a sequence of three high-speed sliding events, the magnitude of weakening diminishes progressively from 40% to 15%. The weakening events coincide with dilation of the sliding interface. Moreover, the decrease in the weakening degree with progressive fast-slip events suggest that the hydraulic diffusivity may increase locally near the sliding interface during thermal pressurization-enhanced slip. This could result from stress- or thermally-induced damage to the host rock, which would perhaps increase both permeability and storage capacity, and so possibly decrease the susceptibility of dynamic weakening due to thermal pressurization in subsequent high-speed sliding events. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1998JPCRD..27.1217D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1998JPCRD..27.1217D">The Observed Properties of Liquid Helium at the Saturated Vapor Pressure</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Donnelly, Russell J.; Barenghi, Carlo F. 1998-11-01 The equilibrium and transport properties of liquid 4He are deduced from experimental observations at the saturated vapor pressure. In each case, the bibliography lists all known measurements. Quantities reported here include density, thermal expansion coefficient, dielectric constant, superfluid and normal fluid densities, first, second, third, and fourth sound velocities, specific heat, enthalpy, entropy, surface tension, ion mobilities, mutual friction, viscosity and kinematic viscosity, dispersion curve, structure factor, thermal conductivity, latent heat, saturated vapor pressure, thermal diffusivity and Prandtl number of helium I, and displacement length and vortex core parameter in helium II. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21358850','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21358850">Sleep deprivation increases blood pressure in healthy normotensive elderly and attenuates the blood pressure response to orthostatic challenge.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Robillard, Rébecca; Lanfranchi, Paola A; Prince, François; Filipini, Daniel; Carrier, Julie 2011-03-01 To determine how aging affects the impact of sleep deprivation on blood pressure at rest and under orthostatic challenge. Subjects underwent a night of sleep and 24.5 h of sleep deprivation in a crossover counterbalanced design. Sleep laboratory. Sixteen healthy normotensive men and women: 8 young adults (mean 24 years [SD 3.1], range 20-28 years) and 8 elderly adults (mean 64.1 years [SD 3.4], range 60-69 years). Sleep deprivation. Brachial cuff arterial blood pressure and heart rate were measured in semi-recumbent and upright positions. These measurements were compared across homeostatic sleep pressure conditions and age groups. Sleep deprivation induced a significant increase in systolic and diastolic blood pressure in elderly but not young adults. Moreover, sleep deprivation attenuated the systolic blood pressure orthostatic response in both age groups. Our results suggest that sleep deprivation alters the regulatory mechanisms of blood pressure and might increase the risk of hypertension in healthy normotensive elderly. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4422025','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4422025">Beluga (Delphinapterus leucas) granulocytes and monocytes display variable responses to in vitro pressure exposures</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Thompson, Laura A.; Romano, Tracy A. 2015-01-01 While it is widely known that marine mammals possess adaptations which allow them to make repetitive and extended dives to great depths without suffering ill effects seen in humans, the response of marine mammal immune cells to diving is unknown. Renewed interest in marine mammal dive physiology has arisen due to reports of decompression sickness-like symptoms and embolic damage in stranded and by-caught animals, and there is concern over whether anthropogenic activities can impact marine mammal health by disrupting adaptive dive responses and behavior. This work addresses the need for information concerning marine mammal immune function during diving by evaluating granulocyte and monocyte phagocytosis, and granulocyte activation in belugas (n = 4) in comparison with humans (n = 4), with and without in vitro pressure exposures. In addition, the potential for additional stressors to impact immune function was investigated by comparing the response of beluga cells to pressure between baseline and stressor conditions. Granulocyte and monocyte phagocytosis, as well as granulocyte activation, were compared between pressure exposed and non-exposed cells for each condition, between different pressure profiles and between conditions using mixed generalized linear models (α = 0.05). The effects of pressure varied between species as well by depth, compression/decompression rates, and length of exposures, and condition for belugas. Pressure induced changes in granulocyte and monocyte function in belugas could serve a protective function against dive-related pathologies and differences in the response between humans and belugas could reflect degrees of dive adaptation. The alteration of these responses during physiologically challenging conditions may increase the potential for dive-related in jury and disease in marine mammals. PMID:25999860 </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li class="active">7</li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_8" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li class="active">8</li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="141"> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25999860','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25999860">Beluga (Delphinapterus leucas) granulocytes and monocytes display variable responses to in vitro pressure exposures.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Thompson, Laura A; Romano, Tracy A 2015-01-01 While it is widely known that marine mammals possess adaptations which allow them to make repetitive and extended dives to great depths without suffering ill effects seen in humans, the response of marine mammal immune cells to diving is unknown. Renewed interest in marine mammal dive physiology has arisen due to reports of decompression sickness-like symptoms and embolic damage in stranded and by-caught animals, and there is concern over whether anthropogenic activities can impact marine mammal health by disrupting adaptive dive responses and behavior. This work addresses the need for information concerning marine mammal immune function during diving by evaluating granulocyte and monocyte phagocytosis, and granulocyte activation in belugas (n = 4) in comparison with humans (n = 4), with and without in vitro pressure exposures. In addition, the potential for additional stressors to impact immune function was investigated by comparing the response of beluga cells to pressure between baseline and stressor conditions. Granulocyte and monocyte phagocytosis, as well as granulocyte activation, were compared between pressure exposed and non-exposed cells for each condition, between different pressure profiles and between conditions using mixed generalized linear models (α = 0.05). The effects of pressure varied between species as well by depth, compression/decompression rates, and length of exposures, and condition for belugas. Pressure induced changes in granulocyte and monocyte function in belugas could serve a protective function against dive-related pathologies and differences in the response between humans and belugas could reflect degrees of dive adaptation. The alteration of these responses during physiologically challenging conditions may increase the potential for dive-related in jury and disease in marine mammals. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/2312454','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/2312454">Responses to negative pressure surrounding the neck in anesthetized animals.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Wolin, A D; Strohl, K P; Acree, B N; Fouke, J M 1990-01-01 Continuous positive pressure applied at the nose has been shown to cause a decrease in upper airway resistance. The present study was designed to determine whether a similar positive transmural pressure gradient, generated by applying a negative pressure at the body surface around the neck, altered upper airway patency. Studies were performed in nine spontaneously breathing anesthetized supine dogs. Airflow was measured with a pneumotachograph mounted on an airtight muzzle placed over the nose and mouth of each animal. Upper airway pressure was measured as the differential pressure between the extrathoracic trachea and the inside of the muzzle. Upper airway resistance was monitored as an index of airway patency. Negative pressure (-2 to -20 cmH2O) was applied around the neck by using a cuirass extending from the jaw to the thorax. In each animal, increasingly negative pressures were transmitted to the airway wall in a progressive, although not linear, fashion. Decreasing the pressure produced a progressive fall in upper airway resistance, without causing a significant change in respiratory drive or respiratory timing. At -5 cmH2O pressure, there occurred a significant fall in upper airway resistance, comparable with the response of a single, intravenous injection of sodium cyanide (0.5-3.0 mg), a respiratory stimulant that produces substantial increases in respiratory drive. We conclude that upper airway resistance is influenced by the transmural pressure across the airway wall and that such a gradient can be accomplished by making the extraluminal pressure more negative.(ABSTRACT TRUNCATED AT 250 WORDS) </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2007PhDT........32D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2007PhDT........32D">Dynamic response of a collidant impacting a low pressure airbag</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Dreher, Peter A. There are many uses of low pressure airbags, both military and commercial. Many of these applications have been hampered by inadequate and inaccurate modeling tools. This dissertation contains the derivation of a four degree-of-freedom system of differential equations from physical laws of mass and energy conservation, force equilibrium, and the Ideal Gas Law. Kinematic equations were derived to model a cylindrical airbag as a single control volume impacted by a parallelepiped collidant. An efficient numerical procedure was devised to solve the simplified system of equations in a manner amenable to discovering design trends. The largest public airbag experiment, both in scale and scope, was designed and built to collect data on low-pressure airbag responses, otherwise unavailable in the literature. The experimental results were compared to computational simulations to validate the simplified numerical model. Experimental response trends are presented that will aid airbag designers. The two objectives of using a low pressure airbag to demonstrate the feasibility to (1) accelerate a munition to 15 feet per second velocity from a bomb bay, and (2) decelerate humans hitting trucks below the human tolerance level of 50 G's, were both met. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3303806','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3303806">Observation of Live Ticks (Haemaphysalis flava) by Scanning Electron Microscopy under High Vacuum Pressure</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Ishigaki, Yasuhito; Nakamura, Yuka; Oikawa, Yosaburo; Yano, Yasuhiro; Kuwabata, Susumu; Nakagawa, Hideaki; Tomosugi, Naohisa; Takegami, Tsutomu 2012-01-01 Scanning electron microscopes (SEM), which image sample surfaces by scanning with an electron beam, are widely used for steric observations of resting samples in basic and applied biology. Various conventional methods exist for SEM sample preparation. However, conventional SEM is not a good tool to observe living organisms because of the associated exposure to high vacuum pressure and electron beam radiation. Here we attempted SEM observations of live ticks. During 1.5×10−3 Pa vacuum pressure and electron beam irradiation with accelerated voltages (2–5 kV), many ticks remained alive and moved their legs. After 30-min observation, we removed the ticks from the SEM stage; they could walk actively under atmospheric pressure. When we tested 20 ticks (8 female adults and 12 nymphs), they survived for two days after SEM observation. These results indicate the resistance of ticks against SEM observation. Our second survival test showed that the electron beam, not vacuum conditions, results in tick death. Moreover, we describe the reaction of their legs to electron beam exposure. These findings open the new possibility of SEM observation of living organisms and showed the resistance of living ticks to vacuum condition in SEM. These data also indicate, for the first time, the usefulness of tick as a model system for biology under extreme condition. PMID:22431980 </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2004APS..DFD.FF007H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2004APS..DFD.FF007H">Characterization of the Dynamic Pressure Response of Fuels in Microchannels</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Haendler, Brenda; Pisano, Albert; Liepmann, Dorian 2004-11-01 In order to create a self-pumping fuel vaporization and delivery systems for a MEMS rotary engine power system, the dynamic pressure response due to phase eruption of fuels in micro channels must be characterized. Testing is done using micro channels with diameters the same order of magnitude as the critical bubble radius, a constant mass flow rate syringe pump, and a steady heat source. Pressure changes in the micro channel due to the periodic movement of the phase change meniscus are measured for a variety of flow conditions. A discrete Fourier transform is performed on the data to determine the dominant frequencies in the signal. Critical trends are discussed comparing both the frequency and the amplitude of the pressure spikes for a variety of temperatures and flow rates. The results presented on the trends in the pressure signature due to phase eruption for fuels are then related back to the fuel delivery system, which is using a nozzle-diffuser design to accomplish positive flow rectification given the periodic pressure condition at the phase eruption interface. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4125597','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4125597">The effect of baseline pressure errors on an intracranial pressure-derived index: results of a prospective observational study</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> 2014-01-01 Background In order to characterize the intracranial pressure-volume reserve capacity, the correlation coefficient (R) between the ICP wave amplitude (A) and the mean ICP level (P), the RAP index, has been used to improve the diagnostic value of ICP monitoring. Baseline pressure errors (BPEs), caused by spontaneous shifts or drifts in baseline pressure, cause erroneous readings of mean ICP. Consequently, BPEs could also affect ICP indices such as the RAP where in the mean ICP is incorporated. Methods A prospective, observational study was carried out on patients with aneurysmal subarachnoid hemorrhage (aSAH) undergoing ICP monitoring as part of their surveillance. Via the same burr hole in the scull, two separate ICP sensors were placed close to each other. For each consecutive 6-sec time window, the dynamic mean ICP wave amplitude (MWA; measure of the amplitude of the single pressure waves) and the static mean ICP, were computed. The RAP index was computed as the Pearson correlation coefficient between the MWA and the mean ICP for 40 6-sec time windows, i.e. every subsequent 4-min period (method 1). We compared this approach with a method of calculating RAP using a 4-min moving window updated every 6 seconds (method 2). Results The study included 16 aSAH patients. We compared 43,653 4-min RAP observations of signals 1 and 2 (method 1), and 1,727,000 6-sec RAP observations (method 2). The two methods of calculating RAP produced similar results. Differences in RAP ≥0.4 in at least 7% of observations were seen in 5/16 (31%) patients. Moreover, the combination of a RAP of ≥0.6 in one signal and <0.6 in the other was seen in ≥13% of RAP-observations in 4/16 (25%) patients, and in ≥8% in another 4/16 (25%) patients. The frequency of differences in RAP >0.2 was significantly associated with the frequency of BPEs (5 mmHg ≤ BPE <10 mmHg). Conclusions Simultaneous monitoring from two separate, close-by ICP sensors reveals significant differences in RAP that </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018PhRvF...3f3602B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018PhRvF...3f3602B">Observation of the pressure effect in simulations of droplets splashing on a dry surface</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Boelens, A. M. P.; Latka, A.; de Pablo, J. J. 2018-06-01 At atmospheric pressure, a drop of ethanol impacting on a solid surface produces a splash. Reducing the ambient pressure below its atmospheric value suppresses this splash. The origin of this so-called pressure effect is not well understood, and this study presents an in-depth comparison between various theoretical models that aim to predict splashing and simulations. In this paper, the pressure effect is explored numerically by resolving the Navier-Stokes equations at a 3-nm resolution. In addition to reproducing numerous experimental observations, it is found that different models all provide elements of what is observed in the simulations. The skating droplet model correctly predicts the existence and scaling of a gas film under the droplet, the lamella formation theory is able to correctly predict the scaling of the lamella ejection velocity as a function of the impact velocity for liquids with different viscosity, and lastly, the dewetting theory's hypothesis of a lift force acting on the liquid sheet after ejection is consistent with our results. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4830622','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4830622">Differential Post-Exercise Blood Pressure Responses between Blacks and Caucasians</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Yan, Huimin; Behun, Michael A.; Cook, Marc D.; Ranadive, Sushant M.; Lane-Cordova, Abbi D.; Kappus, Rebecca M.; Woods, Jeffrey A.; Wilund, Kenneth R.; Baynard, Tracy; Halliwill, John R.; Fernhall, Bo 2016-01-01 Post-exercise hypotension (PEH) is widely observed in Caucasians (CA) and is associated with histamine receptors 1- and 2- (H1R and H2R) mediated post-exercise vasodilation. However, it appears that blacks (BL) may not exhibit PEH following aerobic exercise. Hence, this study sought to determine the extent to which BL develop PEH, and the contribution of histamine receptors to PEH (or lack thereof) in this population. Forty-nine (22 BL, 27 CA) young and healthy subjects completed the study. Subjects were randomly assigned to take either a combined H1R and H2R antagonist (fexofenadine and ranitidine) or a control placebo. Supine blood pressure (BP), cardiac output and peripheral vascular resistance measurements were obtained at baseline, as well as at 30 min, 60 min and 90 min after 45 min of treadmill exercise at 70% heart rate reserve. Exercise increased diastolic BP in young BL but not in CA. Post-exercise diastolic BP was also elevated in BL after exercise with histamine receptor blockade. Moreover, H1R and H2R blockade elicited differential responses in stroke volume between BL and CA at rest, and the difference remained following exercise. Our findings show differential BP responses following exercise in BL and CA, and a potential role of histamine receptors in mediating basal and post-exercise stroke volume in BL. The heightened BP and vascular responses to exercise stimulus is consistent with the greater CVD risk in BL. PMID:27074034 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27074034','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27074034">Differential Post-Exercise Blood Pressure Responses between Blacks and Caucasians.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Yan, Huimin; Behun, Michael A; Cook, Marc D; Ranadive, Sushant M; Lane-Cordova, Abbi D; Kappus, Rebecca M; Woods, Jeffrey A; Wilund, Kenneth R; Baynard, Tracy; Halliwill, John R; Fernhall, Bo 2016-01-01 Post-exercise hypotension (PEH) is widely observed in Caucasians (CA) and is associated with histamine receptors 1- and 2- (H1R and H2R) mediated post-exercise vasodilation. However, it appears that blacks (BL) may not exhibit PEH following aerobic exercise. Hence, this study sought to determine the extent to which BL develop PEH, and the contribution of histamine receptors to PEH (or lack thereof) in this population. Forty-nine (22 BL, 27 CA) young and healthy subjects completed the study. Subjects were randomly assigned to take either a combined H1R and H2R antagonist (fexofenadine and ranitidine) or a control placebo. Supine blood pressure (BP), cardiac output and peripheral vascular resistance measurements were obtained at baseline, as well as at 30 min, 60 min and 90 min after 45 min of treadmill exercise at 70% heart rate reserve. Exercise increased diastolic BP in young BL but not in CA. Post-exercise diastolic BP was also elevated in BL after exercise with histamine receptor blockade. Moreover, H1R and H2R blockade elicited differential responses in stroke volume between BL and CA at rest, and the difference remained following exercise. Our findings show differential BP responses following exercise in BL and CA, and a potential role of histamine receptors in mediating basal and post-exercise stroke volume in BL. The heightened BP and vascular responses to exercise stimulus is consistent with the greater CVD risk in BL. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28457517','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28457517">Direct high-pressure NMR observation of dipicolinic acid leaking from bacterial spore: A crucial step for thermal inactivation.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Akasaka, Kazuyuki; Maeno, Akihiro; Yamazaki, Akira 2017-12-01 A bacterial spore protects itself with an unusually high concentration (~10% in dry weight of spore) of dipicolinic acid (DPA), the release of which is considered the crucial step for inactivating it under mild pressure and temperature conditions. However, the process of how the spore releases DPA in response to pressure remains obscure. Here we apply 1 H high-resolution high-pressure NMR spectroscopy, for the first time, to the spore suspension of Bacillus subtilis natto and monitor directly and in real-time the leaking process of DPA in response to pressure of 200MPa at 20°C. We find that about one third of the total DPA leaks immediately upon applying pressure, but that the rest leaks slowly in hrs upon decreasing the pressure. Once DPA is fully released from the spore, the proteins of the spore become easily denatured at a mild temperature, e.g., 80°C, much below the temperature commonly used to inactivate spores (121°C). The success of the present experiment opens a new avenue for studying bacterial spores and cells at the molecular level in response to pressure, temperature and other perturbations. Copyright © 2017 Elsevier B.V. All rights reserved. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3577519','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3577519">Constriction of isolated collecting lymphatic vessels in response to acute increases in downstream pressure</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Scallan, Joshua P; Wolpers, John H; Davis, Michael J 2013-01-01 Collecting lymphatic vessels generate pressure to transport lymph downstream to the subclavian vein against a significant pressure head. To investigate their response to elevated downstream pressure, collecting lymphatic vessels containing one valve (incomplete lymphangion) or two valves (complete lymphangion) were isolated from the rat mesentery and tied to glass cannulae capable of independent pressure control. Downstream pressure was selectively raised to various levels, either stepwise or ramp-wise, while keeping upstream pressure constant. Diameter and valve positions were tracked under video microscopy, while intralymphangion pressure was measured concurrently with a servo-null micropipette. Surprisingly, a potent lymphatic constriction occurred in response to the downstream pressure gradient due to (1) a pressure-dependent myogenic constriction and (2) a frequency-dependent decrease in diastolic diameter. The myogenic index of the lymphatic constriction (−3.3 ± 0.6, in mmHg) was greater than that of arterioles or collecting lymphatic vessels exposed to uniform increases in pressure (i.e. upstream and downstream pressures raised together). Additionally, the constriction was transmitted to the upstream lymphatic vessel segment even though it was protected from changes in pressure by a closed intraluminal valve; the conducted constriction was blocked by loading only the pressurized half of the vessel with either ML-7 (0.5 mm) to block contraction, or cromakalim (3 μm) to hyperpolarize the downstream muscle layer. Finally, we provide evidence that the lymphatic constriction is important to maintain normal intraluminal valve closure during each contraction cycle in the face of an adverse pressure gradient, which probably protects the lymphatic capillaries from lymph backflow. PMID:23045335 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4747898','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4747898">LRRC10 is required to maintain cardiac function in response to pressure overload</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Brody, Matthew J.; Feng, Li; Grimes, Adrian C.; Hacker, Timothy A.; Olson, Timothy M.; Kamp, Timothy J. 2015-01-01 We previously reported that the cardiomyocyte-specific leucine-rich repeat containing protein (LRRC)10 has critical functions in the mammalian heart. In the present study, we tested the role of LRRC10 in the response of the heart to biomechanical stress by performing transverse aortic constriction on Lrrc10-null (Lrrc10−/−) mice. Mild pressure overload induced severe cardiac dysfunction and ventricular dilation in Lrrc10−/− mice compared with control mice. In addition to dilation and cardiomyopathy, Lrrc10−/− mice showed a pronounced increase in heart weight with pressure overload stimulation and a more dramatic loss of cardiac ventricular performance, collectively suggesting that the absence of LRRC10 renders the heart more disease prone with greater hypertrophy and structural remodeling, although rates of cardiac fibrosis and myocyte dropout were not different from control mice. Lrrc10−/− cardiomyocytes also exhibited reduced contractility in response to β-adrenergic stimulation, consistent with loss of cardiac ventricular performance after pressure overload. We have previously shown that LRRC10 interacts with actin in the heart. Here, we show that His150 of LRRC10 was required for an interaction with actin, and this interaction was reduced after pressure overload, suggesting an integral role for LRRC10 in the response of the heart to mechanical stress. Importantly, these experiments demonstrated that LRRC10 is required to maintain cardiac performance in response to pressure overload and suggest that dysregulated expression or mutation of LRRC10 may greatly sensitize human patients to more severe cardiac disease in conditions such as chronic hypertension or aortic stenosis. PMID:26608339 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26608339','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26608339">LRRC10 is required to maintain cardiac function in response to pressure overload.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Brody, Matthew J; Feng, Li; Grimes, Adrian C; Hacker, Timothy A; Olson, Timothy M; Kamp, Timothy J; Balijepalli, Ravi C; Lee, Youngsook 2016-01-15 We previously reported that the cardiomyocyte-specific leucine-rich repeat containing protein (LRRC)10 has critical functions in the mammalian heart. In the present study, we tested the role of LRRC10 in the response of the heart to biomechanical stress by performing transverse aortic constriction on Lrrc10-null (Lrrc10(-/-)) mice. Mild pressure overload induced severe cardiac dysfunction and ventricular dilation in Lrrc10(-/-) mice compared with control mice. In addition to dilation and cardiomyopathy, Lrrc10(-/-) mice showed a pronounced increase in heart weight with pressure overload stimulation and a more dramatic loss of cardiac ventricular performance, collectively suggesting that the absence of LRRC10 renders the heart more disease prone with greater hypertrophy and structural remodeling, although rates of cardiac fibrosis and myocyte dropout were not different from control mice. Lrrc10(-/-) cardiomyocytes also exhibited reduced contractility in response to β-adrenergic stimulation, consistent with loss of cardiac ventricular performance after pressure overload. We have previously shown that LRRC10 interacts with actin in the heart. Here, we show that His(150) of LRRC10 was required for an interaction with actin, and this interaction was reduced after pressure overload, suggesting an integral role for LRRC10 in the response of the heart to mechanical stress. Importantly, these experiments demonstrated that LRRC10 is required to maintain cardiac performance in response to pressure overload and suggest that dysregulated expression or mutation of LRRC10 may greatly sensitize human patients to more severe cardiac disease in conditions such as chronic hypertension or aortic stenosis. Copyright © 2016 the American Physiological Society. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27352226','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27352226">Effects of light on responses to low atmospheric pressure stunning in broilers.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Martin, J E; Christensen, K; Vizzier-Thaxton, Y; McKeegan, D E F 2016-10-01 Low atmospheric pressure stunning (LAPS) is a novel approach to poultry stunning involving the application of gradual decompression lasting 280 s according to a prescribed pressure curve. The aim of this study was to determine how behavioural, electroencephalogram (EEG) and electrocardiogram (ECG) responses to LAPS are influenced by illumination of the decompression chamber. A secondary aim was to examine responses to the decompression chamber without LAPS being applied, as such a "sham" control has been absent in previous studies. A two by two factorial design was employed, with LAPS/light, LAPS/dark, sham/light and sham/dark treatments (N = 20 per treatment). Broilers were exposed to each treatment in pairs, in each of which one bird was instrumented for recording EEG and ECG. Illumination was applied at 500 lx, and in sham treatments, birds were identically handled but remained undisturbed in the LAPS chamber without decompression for 280 s. Birds which underwent the sham treatment exhibited behaviours which were also observed in LAPS (e.g. sitting) while those exposed to LAPS exhibited hypoxia-related behaviours (e.g. ataxia, loss of posture). Behavioural latencies and durations were increased in the sham treatments, since the whole cycle time was available (in LAPS; birds were motionless by 186 s). Within the sham treatments, illumination increased active behaviour and darkness induced sleep, but slow-wave EEG was seen in both. The pattern of EEG response to LAPS (steep reduction in median frequency in the first 60 s and increased total power) was similar, irrespective of illumination, though birds in darkness had shorter latencies to loss of consciousness and isoelectric EEG. Cardiac responses to LAPS (pronounced bradycardia) closely matched those reported previously and were not affected by illumination. The effects of LAPS/sham treatment primarily reflected the presence/absence of hypoxia, while illumination affected activity/sleep levels in sham </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27690366','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27690366">Rate of rise in diastolic blood pressure influences vascular sympathetic response to mental stress.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> El Sayed, Khadigeh; Macefield, Vaughan G; Hissen, Sarah L; Joyner, Michael J; Taylor, Chloe E 2016-12-15 Research indicates that individuals may experience a rise (positive responders) or fall (negative responders) in muscle sympathetic nerve activity (MSNA) during mental stress. In this study, we examined the early blood pressure responses (including the peak, time of peak and rate of rise in blood pressure) to mental stress in positive and negative responders. Negative MSNA responders to mental stress exhibit a more rapid rise in diastolic pressure at the onset of the stressor, suggesting a baroreflex-mediated suppression of MSNA. In positive responders there is a more sluggish rise in blood pressure during mental stress, which appears to be MSNA-driven. This study suggests that whether MSNA has a role in the pressor response is dependent upon the reactivity of blood pressure early in the task. Research indicates that individuals may experience a rise (positive responders) or fall (negative responders) in muscle sympathetic nerve activity (MSNA) during mental stress. The aim was to examine the early blood pressure response to stress in positive and negative responders and thus its influence on the direction of change in MSNA. Blood pressure and MSNA were recorded continuously in 21 healthy young males during 2 min mental stressors (mental arithmetic, Stroop test) and physical stressors (cold pressor, handgrip exercise, post-exercise ischaemia). Participants were classified as negative or positive responders according to the direction of the mean change in MSNA during the stressor tasks. The peak changes, time of peak and rate of changes in blood pressure were compared between groups. During mental arithmetic negative responders experienced a significantly greater rate of rise in diastolic blood pressure in the first minute of the task (1.3 ± 0.5 mmHg s -1 ) compared with positive responders (0.4 ± 0.1 mmHg s -1 ; P = 0.03). Similar results were found for the Stroop test. Physical tasks elicited robust parallel increases in blood pressure and MSNA across </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5157061','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5157061">Rate of rise in diastolic blood pressure influences vascular sympathetic response to mental stress</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> El Sayed, Khadigeh; Macefield, Vaughan G.; Hissen, Sarah L.; Joyner, Michael J. 2016-01-01 Key points Research indicates that individuals may experience a rise (positive responders) or fall (negative responders) in muscle sympathetic nerve activity (MSNA) during mental stress.In this study, we examined the early blood pressure responses (including the peak, time of peak and rate of rise in blood pressure) to mental stress in positive and negative responders.Negative MSNA responders to mental stress exhibit a more rapid rise in diastolic pressure at the onset of the stressor, suggesting a baroreflex‐mediated suppression of MSNA. In positive responders there is a more sluggish rise in blood pressure during mental stress, which appears to be MSNA‐driven.This study suggests that whether MSNA has a role in the pressor response is dependent upon the reactivity of blood pressure early in the task. Abstract Research indicates that individuals may experience a rise (positive responders) or fall (negative responders) in muscle sympathetic nerve activity (MSNA) during mental stress. The aim was to examine the early blood pressure response to stress in positive and negative responders and thus its influence on the direction of change in MSNA. Blood pressure and MSNA were recorded continuously in 21 healthy young males during 2 min mental stressors (mental arithmetic, Stroop test) and physical stressors (cold pressor, handgrip exercise, post‐exercise ischaemia). Participants were classified as negative or positive responders according to the direction of the mean change in MSNA during the stressor tasks. The peak changes, time of peak and rate of changes in blood pressure were compared between groups. During mental arithmetic negative responders experienced a significantly greater rate of rise in diastolic blood pressure in the first minute of the task (1.3 ± 0.5 mmHg s−1) compared with positive responders (0.4 ± 0.1 mmHg s−1; P = 0.03). Similar results were found for the Stroop test. Physical tasks elicited robust parallel increases in blood </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5280812','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5280812">Can we predict the blood pressure response to renal denervation?</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Fink, Gregory D.; Phelps, Jeremiah T. 2016-01-01 Renal denervation (RDN) is a new therapy used to treat drug-resistant hypertension in the clinical setting. Published human trials show substantial inter-individual variability in the blood pressure (BP) response to RDN, even when technical aspects of the treatment are standardized as much as possible between patients. Widespread acceptance of RDN for treating hypertension will require accurate identification of patients likely to respond to RDN with a fall in BP that is clinically significant in magnitude, well-maintained over time and does not cause adverse consequences. In this paper we review and evaluate clinical studies that address possible predictors of the BP response to RDN. We conclude that only one generally reliable predictor has been identified to date, namely pre-RDN BP level, although there is some evidence for a few other factors. Experimental interventions in laboratory animals provide the opportunity to explore potential predictors that are difficult to investigate in human patients. Therefore we also describe results (from our lab and others) with RDN in spontaneously hypertensive rats. Since virtually all patients receiving RDN are taking three or more antihypertensive drugs, a particular focus of our work was on how ongoing antihypertensive drug treatment might alter the BP response to RDN. We conclude that patient age (or duration of hypertension) and concomitant treatment with certain drugs can affect the blood pressure response to RDN and that this information could help predict a favorable clinical response. PMID:27530600 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2940460','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2940460">Caffeine and Blood Pressure Response: Sex, Age, and Hormonal Status</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Whitsett, Thomas L.; McKey, Barbara S.; Wilson, Michael F.; Vincent, Andrea S.; Everson-Rose, Susan A.; Lovallo, William R. 2010-01-01 Abstract Purpose The pressor effect of caffeine has been established in young men and premenopausal women. The effect of caffeine on blood pressure (BP) remains unknown in postmenopausal women and in relation to hormone replacement therapy (HRT) use. Materials and Methods In a randomized, 2-week cross-over design, we studied 165 healthy men and women in 6 groups: men and premenopausal women (35–-49 yrs) vs. men and postmenopausal women (50–-64 yrs), with postmenopausal women divided into those taking no hormone replacements (HR), estrogen alone, or estrogen and progesterone. Testing during one week of the study involved 6 days of caffeine maintenance at home (80 mg, 3x/day) followed by testing of responses to a challenge dose of caffeine (250 mg) in the laboratory. The other week involved ingesting placebos on maintenance and lab days. Resting BP responses to caffeine were measured at baseline and at 45 to 60 min following caffeine vs placebo ingestion, using automated monitors. Results Ingestion of caffeine resulted in a significant increase in systolic BP in all 6 groups (4 ± .6, p < 0.01). Diastolic BP significantly increased in response to caffeine in all (3 ± .4, p < 0.04) but the group of older men (2 ± 1.0, p = 0.1). The observed pressor responses to caffeine did not vary by age. Conclusions Caffeine resulted in an increase in BP in healthy, normotensive, young and older men and women. This finding warrants the consideration of caffeine in the lifestyle interventions recommended for BP control across the age span. PMID:20500126 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19900033090&hterms=head+circumference&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3Dhead%2Bcircumference','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19900033090&hterms=head+circumference&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3Dhead%2Bcircumference">Effect of a central redistribution of fluid volume on response to lower-body negative pressure</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Tomaselli, Clare M.; Frey, Mary A. B.; Kenney, Richard A.; Hoffler, G. Wyckliffe 1990-01-01 Cardiovascular responses to lower-body negative pressure (LBNP) were studied following 1 hour of 6-deg head-down tilt to determine whether a redistribution of blood volume toward the central circulation modifies the subsequent response to orthostatic stress. Responses of 12 men, ages 30-39 years, were evaluated by electrocardiography, impedance cardiography, sphygmomanometry, and measurement of calf circumference. During the LBNP that followed head-down tilt, as compared with control LBNP (no preceding head-down tilt) subjects, had smaller stroke volume and cardiac output, greater total peripheral resistance, and less calf enlargement. These differences reflect differences in the variables immediately preceding LBNP. Magnitudes of the responses from pre-LBNP to each pressure stage of the LBNP procedure did not differ between protocols. Mean and diastolic arterial pressures were slightly elevated after LBNP-control, but they fell slightly during LBNP post-tilt. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/7410228','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/7410228">Nonlinear aspects of infrasonic pressure transfer into the perilymph.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Krukowski, B; Carlborg, B; Densert, O 1980-06-01 The perilymphatic pressure was studied in response to various low frequency pressure changes in the ear canal. The pressure transfer was analysed and found to be nonlinear in many aspects. The pressure response was found to contain two time constants representing the inner ear pressure regulating mechanisms. The time constants showed an asymmetry in response to positive and negative going inputs--the effects to some extent proportional to input levels. Further nonlinearities were found when infrasonic sine waves were applied to the ear. Harmonic distortion and modulation appeared. When short bursts of infrasound were introduced a clear d.c. shift was observed as a consequence of an asymmetry in the response to positive and negative going pressure inputs. A temporary change in mean perilymphatic pressure was thus achieved and continued throughout the duration of the signal. At very low frequencies a distinct phase shift was detected in the sine waves. This appeared as a phase lead, breaking the continuity of the output sine wave. </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li class="active">8</li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_9" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li class="active">9</li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="161"> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29570571','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29570571">Cardiac Autonomic and Blood Pressure Responses to an Acute Foam Rolling Session.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Lastova, Kevin; Nordvall, Michael; Walters-Edwards, Michelle; Allnutt, Amy; Wong, Alexei 2018-03-22 Foam Rolling (FR) is a self-myofascial release method that has become extremely popular among athletes and fitness enthusiasts for its ability to improve flexibility and range of motion and alleviate delayed onset muscle soreness. However, the cardiac autonomic modulation and blood pressure (BP) responses induced by an acute FR session are currently unknown. The present study evaluated the effects of an acute session of FR exercise on heart rate variability (HRV) and BP responses in healthy individuals. Fifteen (M=8, F=7) healthy subjects completed either a FR or non-exercise control trial in randomized order. HRV and BP measurements were collected at baseline, 10 and 30 min after each trial. There were significant increases (P < 0.01) in markers of vagal tone (nHF) for 30 min after the FR trial, while no changes from baseline were observed following control. There were also significant decreases (P < 0.05) in markers of sympathetic activity (nLF), sympathovagal balance (nLF/nHF), systolic BP and diastolic BP at 10 and 30 min after the trial KB trial while no changes from baseline were observed after the control trial. Our findings indicate that FR decreases sympathovagal balance for 30 min post-intervention which is concurrent with an important hypotensive effect. Further research is warranted to evaluate the potential cardiovascular protective effects of FR in diverse populations. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/10395429','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/10395429">Physician-applied contact pressure and table force response during unilateral thoracic manipulation.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Kirstukas, S J; Backman, J A 1999-06-01 To measure the applied loading to human subjects during the reinforced unilateral thoracic manipulation. Biomechanical descriptive study. The National College of Chiropractic Clinical Biomechanical Laboratory in Lombard, Illinois. Seven men, ages 24 to 47, with no positive responses regarding muscle relaxants or thoracic spinal fractures, surgeries, or pain. We measured the contact pressure distribution at the physician-subject contact region and extracted three biomechanical parameters. From the measured time-dependent support force magnitudes, we extracted five additional biomechanical parameters. In the application of the reinforced unilateral manipulative treatment, the physician establishes contact and applies a near-static preload force of 250 to 350 N. The dynamic portion of the typical thrust is preceded by a 22% decrease in force magnitude, and the peak thrust magnitude is linearly related to the preload force magnitude. We estimate that the peak contact pressure beneath the chiropractor's pisiform can exceed 1000 kPa, with the highest pressures transmitted over areas as small as 3.6 cm2, depending on manipulative style. This work represents the first attempt at performing simultaneous measurements of the physician-applied loading and table force response and measuring the contact pressure distribution at the physician-patient contact region during chiropractic manipulation. This type of work will lead to a better understanding of the relationship between the dynamic physician-applied normal forces and the resulting load response at the table and gives us additional outcome parameters to quantify manipulative technique. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://pubs.er.usgs.gov/publication/70010089','USGSPUBS'); return false;" href="https://pubs.er.usgs.gov/publication/70010089">High-pressure mechanical instability in rocks</a> <a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a> Byerlee, J.D.; Brace, W.F. 1969-01-01 At a confining pressure of a few kilobars, deformation of many sedimentary rocks, altered mafic rocks, porous volcanic rocks, and sand is ductile, in that instabilities leading to audible elastic shocks are absent. At pressures of 7 to 10 kilobars, however, unstable faulting and stick-slip in certain of these rocks was observed. This high pressure-low temperature instability might be responsible for earthquakes in deeply buried sedimentary or volcanic sequences. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/17839351','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/17839351">High-pressure mechanical instability in rocks.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Byerlee, J D; Brace, W F 1969-05-09 At a confining pressure of a few kilobars, deformation of many sedimentary rocks, altered mafic rocks, porous volcanic rocks, and sand is ductile, in that instabilities leading to audible elastic shocks are absent. At pressures of 7 to 10 kilobars, however, unstable faulting and stick-slip in certain of these rocks was observed. This high pressure-low temperature instability might be responsible for earthquakes in deeply buried sedimentary or volcanic sequences. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19850017768&hterms=Blood+pressure&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3DBlood%2Bpressure','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19850017768&hterms=Blood+pressure&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3DBlood%2Bpressure">Blood Pressure Responses and Mineral Ocorticoid Levels in the Suspended Rat Model for Weightlessness</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Musacchia, X. J.; Steffen, J. M. 1985-01-01 Cardiovascular responses and fluid/electrolyte shifts seen during space flight are attributed to cephalad redistribution of vascular fluid. The antiorthostatic (AO) rat (suspended head down tilted, 15-20 deg) is used to model these responses. Current studies show that elevated blood pressures in A0 rats are sustained for periods up to seven days. Comparisons are made with presuspension rats. Increased blood pressure in head down tilted subjects suggests a specific response to A0 positioning, potentially relatable to cephalad fluid shift. To assess a role for hormonal regulation of sodium excretion, serum aldosterone levels were measured. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://pubs.er.usgs.gov/publication/70020775','USGSPUBS'); return false;" href="https://pubs.er.usgs.gov/publication/70020775">In situ observations of a high-pressure phase of H2O ice</a> <a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a> Chou, I.-Ming; Blank, J.G.; Goncharov, A.F.; Mao, Ho-kwang; Hemley, R.J. 1998-01-01 A previously unknown solid phase of H2O has been identified by its peculiar growth patterns, distinct pressure-temperature melting relations, and vibrational Raman spectra. Morphologies of ice crystals and their pressure-temperature melting relations were directly observed in a hydrothermal diamond-anvil cell for H2O bulk densities between 1203 and 1257 kilograms per cubic meter at temperatures between -10??and 50??C. Under these conditions, four different ice forms were observed to melt: two stable phases, ice V and ice VI, and two metastable phases, ice IV and the new ice phase. The Raman spectra and crystal morphology are consistent with a disordered anisotropic structure with some similarities to ice VI. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3743891','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3743891">Deep Tissue Injury in Development of Pressure Ulcers: A Decrease of Inflammasome Activation and Changes in Human Skin Morphology in Response to Aging and Mechanical Load</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Stojadinovic, Olivera; Minkiewicz, Julia; Sawaya, Andrew; Bourne, Jonathan W.; Torzilli, Peter; de Rivero Vaccari, Juan Pablo; Dietrich, W. Dalton; Keane, Robert W.; Tomic-Canic, Marjana 2013-01-01 Molecular mechanisms leading to pressure ulcer development are scarce in spite of high mortality of patients. Development of pressure ulcers that is initially observed as deep tissue injury is multifactorial. We postulate that biomechanical forces and inflammasome activation, together with ischemia and aging, may play a role in pressure ulcer development. To test this we used a newly-developed bio-mechanical model in which ischemic young and aged human skin was subjected to a constant physiological compressive stress (load) of 300 kPa (determined by pressure plate analyses of a person in a reclining position) for 0.5–4 hours. Collagen orientation was assessed using polarized light, whereas inflammasome proteins were quantified by immunoblotting. Loaded skin showed marked changes in morphology and NLRP3 inflammasome protein expression. Sub-epidermal separations and altered orientation of collagen fibers were observed in aged skin at earlier time points. Aged skin showed significant decreases in the levels of NLRP3 inflammasome proteins. Loading did not alter NLRP3 inflammasome proteins expression in aged skin, whereas it significantly increased their levels in young skin. We conclude that aging contributes to rapid morphological changes and decrease in inflammasome proteins in response to tissue damage, suggesting that a decline in the innate inflammatory response in elderly skin could contribute to pressure ulcer pathogenesis. Observed morphological changes suggest that tissue damage upon loading may not be entirely preventable. Furthermore, newly developed model described here may be very useful in understanding the mechanisms of deep tissue injury that may lead towards development of pressure ulcers. PMID:23967056 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20687117','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20687117">Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Hamilton, Roy; Patel, Sunil; Lee, Edward B; Jackson, Eric M; Lopinto, Joanna; Arnold, Steven E; Clark, Christopher M; Basil, Anuj; Shaw, Leslie M; Xie, Sharon X; Grady, M Sean; Trojanowski, John Q 2010-10-01 To determine the impact of cortical Alzheimer disease pathology on shunt responsiveness in individuals treated for idiopathic normal pressure hydrocephalus (iNPH), 37 patients clinically diagnosed with iNPH participated in a prospective study in which performance on neurologic, psychometric, and gait measures before and 4 months after shunting was correlated with amyloid β plaques, neuritic plaques, and neurofibrillary tangles observed in cortical biopsies obtained during shunt insertion. No complications resulted from biopsy acquisition. Moderate to severe pathology was associated with worse baseline cognitive performance and diminished postoperative improvement on NPH symptom severity scales, gait measures, and cognitive instruments compared to patients lacking pathology. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2964442','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2964442">Lack of Shunt Response in Suspected Idiopathic Normal Pressure Hydrocephalus with Alzheimer Disease Pathology</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Hamilton, Roy; Patel, Sunil; Lee, Edward B.; Jackson, Eric M.; Lopinto, Joanna; Arnold, Steven E.; Clark, Christopher M.; Basil, Anuj; Shaw, Leslie M.; Xie, Sharon X.; Grady, M. Sean; Trojanowski, John Q. 2010-01-01 To determine the impact of cortical Alzheimer disease pathology on shunt responsiveness in individuals treated for idiopathic normal pressure hydrocephalus (iNPH), 37 patients clinically diagnosed with iNPH participated in a prospective study in which performance on neurologic, psychometric, and gait measures before and 4 months after shunting was correlated with amyloid β plaques, neuritic plaques, and neurofibrillary tangles observed in cortical biopsies obtained during shunt insertion. No complications resulted from biopsy acquisition. Moderate to severe pathology was associated with worse baseline cognitive performance and diminished postoperative improvement on NPH symptom severity scales, gait measures, and cognitive instruments compared to patients lacking pathology. PMID:20687117 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24445083','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24445083">Reliability of laser Doppler flowmetry curve reading for measurement of toe and ankle pressures: intra- and inter-observer variation.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Høyer, C; Paludan, J P D; Pavar, S; Biurrun Manresa, J A; Petersen, L J 2014-03-01 To assess the intra- and inter-observer variation in laser Doppler flowmetry curve reading for measurement of toe and ankle pressures. A prospective single blinded diagnostic accuracy study was conducted on 200 patients with known or suspected peripheral arterial disease (PAD), with a total of 760 curve sets produced. The first curve reading for this study was performed by laboratory technologists blinded to clinical clues and previous readings at least 3 months after the primary data sampling. The pressure curves were later reassessed following another period of at least 3 months. Observer agreement in diagnostic classification according to TASC-II criteria was quantified using Cohen's kappa. Reliability was quantified using intra-class correlation coefficients, coefficients of variance, and Bland-Altman analysis. The overall agreement in diagnostic classification (PAD/not PAD) was 173/200 (87%) for intra-observer (κ = .858) and 175/200 (88%) for inter-observer data (κ = .787). Reliability analysis confirmed excellent correlation for both intra- and inter-observer data (ICC all ≥.931). The coefficients of variance ranged from 2.27% to 6.44% for intra-observer and 2.39% to 8.42% for inter-observer data. Subgroup analysis showed lower observer-variation for reading of toe pressures in patients with diabetes and/or chronic kidney disease than patients not diagnosed with these conditions. Bland-Altman plots showed higher variation in toe pressure readings than ankle pressure readings. This study shows substantial intra- and inter-observer agreement in diagnostic classification and reading of absolute pressures when using laboratory technologists as observers. The study emphasises that observer variation for curve reading is an important factor concerning the overall reproducibility of the method. Our data suggest diabetes and chronic kidney disease have an influence on toe pressure reproducibility. Copyright © 2013 European Society for Vascular Surgery. Published </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19930064672&hterms=applied+optics&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3Dapplied%2Boptics','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19930064672&hterms=applied+optics&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3Dapplied%2Boptics">Pressure dependence of the electro-optic response function in partially exposed polymer dispersed ferroelectric liquid crystals</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Parmar, D. S.; Holmes, H. K. 1993-01-01 Ferroelectric liquid crystals in a new configuration, termed partially exposed polymer dispersed ferroelectric liquid crystal (PEPDFLC), respond to external pressures and demonstrate pressure-induced electro-optic switching response. When the PEPDFLC thin film is sandwiched between two transparent conducting electrodes, one a glass plate and the other a flexible sheet such as polyvenylidene fluoride, the switching characteristics of the thin film are a function of the pressure applied to the flexible transparent electrode and the bias voltage across the electrodes. Response time measurements reveal a linear dependence of the change in electric field with external pressure. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/5471333-copernicus-observations-pressures-carbon-abundances-diffuse-interstellar-clouds','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/5471333-copernicus-observations-pressures-carbon-abundances-diffuse-interstellar-clouds">Copernicus observations of C I: pressures and carbon abundances in diffuse interstellar clouds</a> <a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a> Jenkins, E.B.; Jura, M.; Loewenstein, M. 1983-07-01 Using the Copernicus satellite, we observed ultraviolet absorption lines of interstellar neutral carbon atoms toward 27 stars. In addition to deriving column densities of C I (both in its ground state and the two excited fine-structure levels), we used our equivalent widths to revise the f-values of some of the C I transitions measured by other investigators. We also observed H/sub 2/ from the J = 4 level so that we could compare the rotational excitation of H/sub 2/ with the fine-structure excitation of C I. From the amount of fine-structure excitation of C I in each case, we havemore » derived information on the thermal gas pressures within the diffuse clouds. Most clouds have p/k between 10/sup 3/ cm/sup -3/ K and 10/sup 4/ cm/sup -3/ K, but we found that at least 6% of the C I-bearing material is at p/k>10/sup 4/ cm/sup -3/ K, and one-third of the gas has upper limits for pressure below 10/sup 3/ cm/sup -3/ K, assuming temperatures are not appreciably below 20 K. An analysis of radial velocities for the absorption lines showed no distinctive trends for the kinematics of high- or low-pressure gas components. From the apparent lack of acceleration of high-pressure clouds, we conclude that it is unlikely that streaming intercloud material is causing significant ram pressurization. We have compared our results with the predictions for pressure fluctuations caused by supernova explosions in the theory of McKee and Ostriker.« less </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22771985','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22771985">Social support is associated with blood pressure responses in parents caring for children with developmental disabilities.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Gallagher, Stephen; Whiteley, Jenny 2012-01-01 The present study tested whether parents caring for children with developmental disabilities would have higher blood pressure compared to parents of typically developing children (controls). It also examined the psychosocial factors underlying this observation. Thirty-five parents of children with developmental disability and thirty controls completed standard measures of perceived stress, child challenging behaviours and social support and wore an ambulatory blood pressure (BP) monitor throughout the day, for one day. Relative to controls, parents caring for children with developmental disabilities reported poorer psychosocial functioning and had a higher mean systolic BP. Of the psychosocial predictors, only social support was found to be predictive. Moreover, variations in social support accounted for some of the between group differences with the β for parental group attenuated from .42 to .34 in regression analyses. It appears that social support may influence blood pressure responses in parental caregivers. Finally, our findings underscore the importance of providing psychosocial interventions to improve the health of family caregivers. Copyright © 2012 Elsevier Ltd. All rights reserved. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/9128214','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/9128214">Evaluation of a rapid protocol for the assessment of salt sensitivity against the blood pressure response to dietary sodium chloride restriction.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Galletti, F; Ferrara, I; Stinga, F; Iacone, R; Noviello, F; Strazzullo, P 1997-04-01 The "gold standard" for the assessment of salt sensitivity of hypertension is the blood pressure response to dietary NaCl restriction; nevertheless, for practical purposes, a more rapid test that would not depend on the patient's compliance to the dietary prescription would be very useful in clinical research and medical practice. The aim of this study was thus to evaluate the effectiveness and reliability of a rapid, easy-to-standardize protocol for the assessment of salt sensitivity against the blood pressure response to dietary salt restriction. A total of 108 hypertensive patients were screened for salt sensitivity by the modified protocol of Grim et al. Thereafter, nine patients identified by the test as salt sensitive and nine identified as salt resistant followed, for two consecutive periods of 1 week, a diet with normal (200 mmol/day) or low (50 mmol/day) NaCl content. Compliance to the diet was checked by repeated 24-h urine collections. The group as a whole experienced a significant fall in blood pressure during the low Na diet (mean pressure = 123 +/- 3 v 118 +/- 3 mm Hg; P < .05). However, whereas patients identified as salt sensitive by the Grim protocol had a marked and significant blood pressure decrease (systolic -12 mm Hg, diastolic -7 mm Hg), no change was observed in those classified as salt resistant (systolic -2 mm Hg, diastolic -2 mm Hg). A significant correlation between changes in urinary Na excretion and changes in blood pressure was found only in salt-sensitive hypertensive patients. In conclusion, the modified Grim protocol tested in this study was able to correctly predict a significant blood pressure response to dietary salt restriction in the majority of cases. A validation of this test in a larger patient population may be advisable. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/3426487','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/3426487">Aerobic fitness in women and responses to lower body negative pressure.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Frey, M A; Mathes, K L; Hoffler, G W 1987-12-01 High aerobic fitness may be associated with impaired responsiveness to orthostatic challenge. This could be detrimental to astronauts returning from spaceflight. Thus, we examined the cardiovascular responses of a group of 45 healthy women to graded lower body negative pressure (LBNP) through 5 min at -50 mm Hg or until they become presyncopal. The ages (range = 23-43 years, mean = 30.4) and peak aerobic capacities (range = 23.0-55.3 ml.kg-1.min-1, mean = 37.8) of these subjects paralleled those of the women astronauts. We monitored heart rate, stroke volume, cardiac output, Heather index of contractility, arterial pressure, peripheral resistance, change in calf circumference, and thoracic impedance (ZO)--a measure of fluid in the chest. The women in this study exhibited the same response pattern to LBNP as previously reported for male subjects. VO2peak of the six subjects who became presyncopal was not different from VO2peak of the tolerant subjects. At rest, only systolic and mean arterial pressures were significantly correlated with VO2peak. Percent changes in calf circumference (i.e. fluid accumulation in the legs) at -30 and -40 mm Hg were the only responses to LBNP significantly related to VO2peak. The greater pooling of blood in the legs during LBNP by women with higher aerobic fitness, and lower percent body fat may be related to more muscle tissue and vasculature in the legs of the more fit subjects. These data indicated that orthostatic tolerance is not related to aerobic capacity in women, and orthostatic tolerance need not be a concern to aerobically fit women astronauts. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4174866','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4174866">CO2 exposure at pressure impacts metabolism and stress responses in the model sulfate-reducing bacterium Desulfovibrio vulgaris strain Hildenborough</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Wilkins, Michael J.; Hoyt, David W.; Marshall, Matthew J.; Alderson, Paul A.; Plymale, Andrew E.; Markillie, L. Meng; Tucker, Abby E.; Walter, Eric D.; Linggi, Bryan E.; Dohnalkova, Alice C.; Taylor, Ron C. 2014-01-01 Geologic carbon dioxide (CO2) sequestration drives physical and geochemical changes in deep subsurface environments that impact indigenous microbial activities. The combined effects of pressurized CO2 on a model sulfate-reducing microorganism, Desulfovibrio vulgaris, have been assessed using a suite of genomic and kinetic measurements. Novel high-pressure NMR time-series measurements using 13C-lactate were used to track D. vulgaris metabolism. We identified cessation of respiration at CO2 pressures of 10 bar, 25 bar, 50 bar, and 80 bar. Concurrent experiments using N2 as the pressurizing phase had no negative effect on microbial respiration, as inferred from reduction of sulfate to sulfide. Complementary pressurized batch incubations and fluorescence microscopy measurements supported NMR observations, and indicated that non-respiring cells were mostly viable at 50 bar CO2 for at least 4 h, and at 80 bar CO2 for 2 h. The fraction of dead cells increased rapidly after 4 h at 80 bar CO2. Transcriptomic (RNA-Seq) measurements on mRNA transcripts from CO2-incubated biomass indicated that cells up-regulated the production of certain amino acids (leucine, isoleucine) following CO2 exposure at elevated pressures, likely as part of a general stress response. Evidence for other poorly understood stress responses were also identified within RNA-Seq data, suggesting that while pressurized CO2 severely limits the growth and respiration of D. vulgaris cells, biomass retains intact cell membranes at pressures up to 80 bar CO2. Together, these data show that geologic sequestration of CO2 may have significant impacts on rates of sulfate reduction in many deep subsurface environments where this metabolism is a key respiratory process. PMID:25309528 </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016AGUFMSM33C2527M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016AGUFMSM33C2527M">The O+ contribution and role on the ring current pressure development for CMEs and CIRs using Van Allen Probes observations</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Mouikis, C.; Bingham, S.; Kistler, L. M.; Farrugia, C. J.; Spence, H. E.; Gkioulidou, M. 2016-12-01 The ring current responds differently to the different solar and interplanetary storm drivers such as coronal mass injections, (CME's), co-rotating interaction regions (CIR's), high-speed streamers and other structures. The resulting changes in the ring current particle pressure change the global magnetic field, which affects the transport of the radiation belts. In order to determine the field changes during a storm, it is necessary to understand the transport, sources and losses of the particles that contribute to the ring current. The source population of the storm time ring current is the night side plasma sheet. We use Van Allen Probes observations to determine the ring current pressure contribution of the convecting plasma sheet H+ and O+ particles in the storm time development of the ring current. We compare storms that are related to different interplanetary drivers, CMEs and CIRs, as observed at different local times. We find that during the storm main phase most of the ring current pressure in the pre-midnight inner magnetosphere is contributed by particles on open drift paths that cause the development of a strong partial ring current that causes most of the main phase Dst drop. These particles can reach as deep as L 2 and their pressure compares to the local magnetic field pressure as deep as L 3. During the recovery phase, if these particles are not lost at the magnetopause, will become trapped and will contribute to the symmetric ring current. However, the largest difference between the CME and CIR ring current responses during the storm main and early recovery phases is caused by how the 15 - 60 keV O+ responds to these drivers. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2829499','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2829499">Cerebrospinal fluid pulse pressure amplitude during lumbar infusion in idiopathic normal pressure hydrocephalus can predict response to shunting</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> 2010-01-01 Background We have previously seen that idiopathic normal pressure hydrocephalus (iNPH) patients having elevated intracranial pressure (ICP) pulse amplitude consistently respond to shunt surgery. In this study we explored how the cerebrospinal fluid pressure (CSFP) pulse amplitude determined during lumbar infusion testing, correlates with ICP pulse amplitude determined during over-night ICP monitoring and with response to shunt surgery. Our goal was to establish a more reliable screening procedure for selecting iNPH patients for shunt surgery using lumbar intrathecal infusion. Methods The study population consisted of all iNPH patients undergoing both diagnostic lumbar infusion testing and continuous over-night ICP monitoring during the period 2002-2007. The severity of iNPH was assessed using our NPH grading scale before surgery and 12 months after shunting. The CSFP pulse was characterized from the amplitude of single pressure waves. Results Totally 62 iNPH patients were included, 45 of them underwent shunt surgery, in whom 78% were shunt responders. Among the 45 shunted patients, resistance to CSF outflow (Rout) was elevated (≥ 12 mmHg/ml/min) in 44. The ICP pulse amplitude recorded over-night was elevated (i.e. mean ICP wave amplitude ≥ 4 mmHg) in 68% of patients; 92% of these were shunt responders. In those with elevated overnight ICP pulse amplitude, we found also elevated CSFP pulse amplitude recorded during lumbar infusion testing, both during the opening phase following lumbar puncture and during a standardized period of lumbar infusion (15 ml Ringer over 10 min). The clinical response to shunting after 1 year strongly associated with the over-night ICP pulse amplitude, and also with the pulsatile CSFP during the period of lumbar infusion. Elevated CSFP pulse amplitude during lumbar infusion thus predicted shunt response with sensitivity of 88 and specificity of 60 (positive and negative predictive values of 89 and 60, respectively). Conclusions In i </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3538510','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3538510">Acute pressure on the sciatic nerve results in rapid inhibition of the wide dynamic range neuronal response</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> 2012-01-01 Background Acute pressure on the sciatic nerve has recently been reported to provide rapid short-term relief of pain in patients with various pathologies. Wide dynamic range (WDR) neurons transmit nociceptive information from the dorsal horn to higher brain centers. In the present study, we examined the effect of a 2-min application of sciatic nerve pressure on WDR neuronal activity in anesthetized male Sprague–Dawley rats. Results Experiments were carried out on 41 male Sprague–Dawley albino rats weighing 160–280 grams. Dorsal horn WDR neurons were identified on the basis of characteristic responses to mechanical stimuli applied to the cutaneous receptive field. Acute pressure was applied for 2 min to the sciatic nerve using a small vascular clip. The responses of WDR neurons to three mechanical stimuli applied to the cutaneous receptive field were recorded before, and 2, 5 and 20 min after cessation of the 2-min pressure application on the sciatic nerve. Two-min pressure applied to the sciatic nerve caused rapid attenuation of the WDR response to pinching, pressure and brushing stimuli applied to the cutaneous receptive field. Maximal attenuation of the WDR response to pinching and pressure was noted 5 min after release of the 2-min pressure on the sciatic nerve. The mean firing rate decreased from 31.7±1.7 Hz to 13±1.4 Hz upon pinching (p < 0.001), from 31.2±2.3 Hz to 10.9±1.4 Hz (p < 0.001) when pressure was applied, and from 18.9±1.2 Hz to 7.6±1.1 Hz (p < 0.001) upon brushing. Thereafter, the mean firing rates gradually recovered. Conclusions Our results indicate that acute pressure applied to the sciatic nerve exerts a rapid inhibitory effect on the WDR response to both noxious and innocuous stimuli. Our results may partially explain the rapid analgesic effect of acute sciatic nerve pressure noted in clinical studies, and also suggest a new model for the study of pain. PMID:23211003 </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2010EGUGA..12.5183E','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2010EGUGA..12.5183E">Insights into aquifer vulnerability and potential recharge zones from the borehole response to barometric pressure changes</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> El Araby, Mahmoud; Odling, Noelle; Clark, Roger; West, Jared 2010-05-01 Borehole water levels fluctuate in response to deformation of the surrounding aquifer caused by surface loading due to barometric pressure or strain caused by Earth and ocean tides. The magnitude and nature of this response mainly depend on the hydraulic properties of the aquifer and overlying units and borehole design. Thus water level responses reflect the effectiveness of a confining unit as a protective layer against aquifer contamination (and therefore groundwater vulnerability) and to potential aquifer recharge/discharge zones. In this study, time series of borehole water levels and barometric pressure are being investigated using time series analysis and signal processing techniques with the aim of developing a methodology for assessing recharge/discharge distribution and groundwater vulnerability in the confined/semi-confined part of the Chalk aquifer in East Yorkshire, UK. The chalk aquifer in East Yorkshire is an important source for industrial and domestic water supply. The aquifer water quality is threatened by surface pollution particularly by nitrates from agricultural fertilizers. The confined/semi-confined part of this aquifer is covered by various types of superficial deposits resulting in a wide range of the aquifer's degree of confinement. A number of boreholes have been selected for monitoring to cover all these various types of confining units. Automatic pressure transducers are installed to record water levels and barometric pressure measurements at each borehole on 15 minutes recording intervals. In strictly confined aquifers, borehole water level response to barometric pressure is an un-drained instantaneous response and is a constant fraction of the barometric pressure changes. This static confined constant is called the barometric efficiency which can be estimated simply by the slope of a regression plot of water levels versus barometric pressure. However, in the semi confined aquifer case this response is lagged due to water movement </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li class="active">9</li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_10" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li class="active">10</li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="181"> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AGUFM.S43C0875C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AGUFM.S43C0875C">Seismic and aseismic fault slip in response to fluid injection observed during field experiments at meter scale</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Cappa, F.; Guglielmi, Y.; De Barros, L.; Wynants-Morel, N.; Duboeuf, L. 2017-12-01 During fluid injection, the observations of an enlarging cloud of seismicity are generally explained by a direct response to the pore pressure diffusion in a permeable fractured rock. However, fluid injection can also induce large aseismic deformations which provide an alternative mechanism for triggering and driving seismicity. Despite the importance of these two mechanisms during fluid injection, there are few studies on the effects of fluid pressure on the partitioning between seismic and aseismic motions under controlled field experiments. Here, we describe in-situ meter-scale experiments measuring synchronously the fluid pressure, the fault motions and the seismicity directly in a fault zone stimulated by controlled fluid injection at 280 m depth in carbonate rocks. The experiments were conducted in a gallery of an underground laboratory in south of France (LSBB, http://lsbb.eu). Thanks to the proximal monitoring at high-frequency, our data show that the fluid overpressure mainly induces a dilatant aseismic slip (several tens of microns up to a millimeter) at the injection. A sparse seismicity (-4 < Mw < -3) is observed several meters away from the injection, in a part of the fault zone where the fluid overpressure is null or very low. Using hydromechanical modeling with friction laws, we simulated an experiment and investigated the relative contribution of the fluid pressure diffusion and stress transfer on the seismic and aseismic fault behavior. The model reproduces the hydromechanical data measured at injection, and show that the aseismic slip induced by fluid injection propagates outside the pressurized zone where accumulated shear stress develops, and potentially triggers seismicity. Our models also show that the permeability enhancement and friction evolution are essential to explain the fault slip behavior. Our experimental results are consistent with large-scale observations of fault motions at geothermal sites (Wei et al., 2015; Cornet, 2016), and </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28102355','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28102355">Determining arterial wave transit time from a single aortic pressure pulse in rats: vascular impulse response analysis.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Chang, Ru-Wen; Chang, Chun-Yi; Lai, Liang-Chuan; Wu, Ming-Shiou; Young, Tai-Horng; Chen, Yih-Sharng; Wang, Chih-Hsien; Chang, Kuo-Chu 2017-01-19 Arterial wave transit time (τ w ) in the lower body circulation is an effective biomarker of cardiovascular risk that substantially affects systolic workload imposed on the heart. This study evaluated a method for determining τ w from the vascular impulse response on the basis of the measured aortic pressure and an assumed triangular flow (Q tri ). The base of the unknown Q tri was constructed with a duration set equal to ejection time. The timing of the peak triangle was derived using a fourth-order derivative of the pressure waveform. Values of τ w s obtained using Q tri were compared with those obtained from the measure aortic flow wave (Q m ). Healthy rats (n = 27), rats with chronic kidney disease (CKD; n = 22), and rats with type 1 (n = 22) or type 2 (n = 11) diabetes were analyzed. The cardiovascular conditions in the CKD rats and both diabetic groups were characterized by a decrease in τ w s. The following significant relation was observed (P < 0.0001): τ w triQ = -1.5709 + 1.0604 × τ w mQ (r 2 = 0.9641). Our finding indicates that aortic impulse response can be an effective method for the estimation of arterial τ w by using a single pressure recording together with the assumed Q tri . </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20040173014&hterms=space+carotid&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Dspace%2Bcarotid','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20040173014&hterms=space+carotid&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Dspace%2Bcarotid">Interaction of central venous pressure, intramuscular pressure, and carotid baroreflex function</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Shi, X.; Foresman, B. H.; Raven, P. B.; Blomqvist, C. G. (Principal Investigator) 1997-01-01 Seven healthy volunteer men participated in an experiment involving lower body positive pressure (LBPP) of 30 Torr and acute volume expansions of 5-6% (VE-I) and 9-10% (VE-II) of their total blood volume (TBV) to differentiate the effect of increased intramuscular pressure and central venous pressure (CVP) on the maximal gain (Gmax) of the carotid baroreflex. During each experimental condition, the heart rate (HR), mean arterial pressure (MAP; intraradial artery or Finapres), and CVP (at the 3rd-4th intercostal space) were monitored continuously. Gmax was derived from the logistic modeling of the HR and MAP responses to ramped changes in carotid sinus transmural pressure using a protocol of pulsatile changes in neck chamber pressure from +40 to -65 Torr. The increase in CVP during +30-Torr LBPP was 1.5 mmHg (P < 0.05) and was similar to that observed during VE-I (1.7 mmHg, P > 0.05). The Gmax of the carotid baroreflex of HR and MAP was significantly decreased during LBPP by -0.145 +/- 0.039 beats x min(-1) x mmHg(-1) (38%) and -0.071 +/- 0.013 mmHg/mmHg (25%), respectively; however, VE-I did not affect Gmax. During VE-II, CVP was significantly greater than that elicited by LBPP, and the Gmax of the carotid baroreflex of the HR and MAP responses was significantly reduced. We conclude that carotid baroreflex responsiveness was selectively inhibited by increasing intramuscular pressure, possibly resulting in an activation of the intramuscular mechanoreceptors during LBPP. Furthermore, it would appear that the inhibition of the carotid baroreflex, via cardiopulmonary baroreceptor loading (increased CVP), occurred when a threshold pressure (CVP) was achieved. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29046978','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29046978">Blood Pressure Response to Exercise and Cardiovascular Disease.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Schultz, Martin G; La Gerche, Andre; Sharman, James E 2017-10-18 This review aimed to provide a clinical update on exercise blood pressure (BP) and its relationship to cardiovascular disease (CVD), outlining key determinants of abnormal exercise BP responses. We also highlight current evidence gaps that need addressing in order to optimise the relevance of exercise BP as clinical CVD risk factor. Abnormal exercise BP manifests as either exercise hypotension (low BP response) or as exaggerated exercise BP (high BP response). Exercise hypotension is an established sign of existing and likely severe CVD, but exaggerated exercise BP also carries elevated CVD risk due to its association with sub-clinical hypertension. Although exaggerated exercise BP is related to heightened CVD risk at any exercise intensity, recent data suggest that the BP response to submaximal intensity exercise holds greater prognostic and clinical significance than BP achieved at peak/maximal intensity exercise. Cardiorespiratory fitness is a strong modifier of the exercise BP response, and should be taken into consideration when assessing the association with CVD. Both exercise hypotension and exaggerated exercise BP serve as markers that should prompt evaluation for potential underlying CVD. However, the clinical utility of these markers is currently inhibited by the lack of consensus informing the definitions and thresholds for abnormalities in exercise BP. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26497611','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26497611">[Associations of the work duration, sleep duration and number of holidays with an exaggerated blood pressure response during an exercise stress test among workers].</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Michishita, Ryoma; Ohta, Masanori; Ikeda, Masaharu; Jiang, Ying; Yamato, Hiroshi 2016-01-01 It has been reported that an exaggerated systolic blood pressure (ESBP) response during exercise, even if resting blood pressure is normal, is associated with an increased risk of future hypertension and cardiovascular disease (CVD). This study was designed to investigate the relationships of work duration, sleep duration and number of holidays with blood pressure response during an exercise stress test among normotensive workers. The subjects were 362 normotensive workers (79 males and 283 females; age, 49.1 years). A multi-stage graded submaximal exercise stress test was performed on each subject using an electric bicycle ergometer. The workload was increased every 3 minutes, and blood pressure was measured at rest and during the last 1 minute of each stage. In this study, an ESBP response during exercise was defined according to the criteria of the Framingham Study (peak systolic blood pressure ≥210 mmHg in males, or ≥190 mmHg in females). Working environments, work duration, sleep duration, number of holidays, and physical activity during commuting and work, and leisure time exercise duration were evaluated using a questionnaire. An ESBP response during exercise was observed in 94 (26.0%) workers. The adjusted odds ratio for the prevalence of an ESBP response during exercise was found to be significantly higher with an increase in work duration, decreases in sleep duration and number of holidays (p<0.05, respectively). Moreover, the highest work duration with lowest sleep duration and number of holidays groups had significantly higher adjusted odds ratio for the prevalence of an ESBP response during exercise than the lowest work duration with highest sleep duration and number of holidays groups (p<0.05, respectively). Based on our results, we consider that the assessment of blood pressure response during exercise and daily life are necessary to prevent the incidence of future hypertension, CVD and death due to overwork in workers with long-work duration </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1286756-high-pressure-dynamics-hydrated-protein-bioprotective-trehalose-environment','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1286756-high-pressure-dynamics-hydrated-protein-bioprotective-trehalose-environment">High-pressure dynamics of hydrated protein in bioprotective trehalose environment</a> <a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a> Diallo, S. O.; Zhang, Q.; O'Neill, H.; ... 2014-10-30 Here we present a pressure-dependence study of the dynamics of lysozyme protein powder immersed in deuterated , α-trehalose environment via quasielastic neutron scattering (QENS). The goal is to assess the baroprotective benefits of trehalose on biomolecules by comparing the findings with those of a trehalose-free reference study. While the mean-square displacement of the trehalose-free protein (hydrated to d D₂O ≃40 w%) as a whole, is reduced by increasing pressure, the actual observable relaxation dynamics in the picoseconds to nanoseconds time range remains largely unaffected by pressure up to the maximum investigated pressure of 2.78(2) Kbar. Our observation is independent ofmore » whether or not the protein is mixed with the deuterated sugar. This suggests that the hydrated protein s conformational states at atmospheric pressure remain unaltered by hydrostatic pressures, below 2.78 Kbar. We also found the QENS response to be totally recoverable after ambient pressure conditions are restored. Small-angle neutron diffraction measurements confirm that the protein-protein correlation remains undisturbed.We observe, however, a clear narrowing of the QENS response as the temperature is decreased from 290 to 230 K in both cases, which we parametrize using the Kohlrausch-Williams-Watts stretched exponential model. Finally, only the fraction of protons that are immobile on the accessible time window of the instrument, referred to as the elastic incoherent structure factor, is observably sensitive to pressure, increasing only marginally but systematically with increasing pressure.« less </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22482774-measurement-vacuum-pressure-magneto-optical-trap-pressure-rise-method','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22482774-measurement-vacuum-pressure-magneto-optical-trap-pressure-rise-method">Measurement of vacuum pressure with a magneto-optical trap: A pressure-rise method</a> <a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a> Moore, Rowan W. G.; Lee, Lucie A.; Findlay, Elizabeth A. 2015-09-15 The lifetime of an atom trap is often limited by the presence of residual background gases in the vacuum chamber. This leads to the lifetime being inversely proportional to the pressure. Here, we use this dependence to estimate the pressure and to obtain pressure rate-of-rise curves, which are commonly used in vacuum science to evaluate the performance of a system. We observe different rates of pressure increase in response to different levels of outgassing in our system. Therefore, we suggest that this is a sensitive method which will find useful applications in cold atom systems, in particular, where the inclusionmore » of a standard vacuum gauge is impractical.« less </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25092496','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25092496">Conformable amplified lead zirconate titanate sensors with enhanced piezoelectric response for cutaneous pressure monitoring.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Dagdeviren, Canan; Su, Yewang; Joe, Pauline; Yona, Raissa; Liu, Yuhao; Kim, Yun-Soung; Huang, YongAn; Damadoran, Anoop R; Xia, Jing; Martin, Lane W; Huang, Yonggang; Rogers, John A 2014-08-05 The ability to measure subtle changes in arterial pressure using devices mounted on the skin can be valuable for monitoring vital signs in emergency care, detecting the early onset of cardiovascular disease and continuously assessing health status. Conventional technologies are well suited for use in traditional clinical settings, but cannot be easily adapted for sustained use during daily activities. Here we introduce a conformal device that avoids these limitations. Ultrathin inorganic piezoelectric and semiconductor materials on elastomer substrates enable amplified, low hysteresis measurements of pressure on the skin, with high levels of sensitivity (~0.005 Pa) and fast response times (~0.1 ms). Experimental and theoretical studies reveal enhanced piezoelectric responses in lead zirconate titanate that follow from integration on soft supports as well as engineering behaviours of the associated devices. Calibrated measurements of pressure variations of blood flow in near-surface arteries demonstrate capabilities for measuring radial artery augmentation index and pulse pressure velocity. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20040110843','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20040110843">Observation of Quartz Cathode-Luminescence in a Low Pressure Plasma Discharge</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Foster, John E. 2004-01-01 Intense, steady-state cathode-luminescence has been observed from exposure of quartz powder to a low pressure rf-excited argon plasma discharge. The emission spectra (400 to 850 nm) associated with the powder luminescence were documented as a function of bias voltage using a spectrometer. The emission was broad-band, essentially washing out the line spectra features of the argon plasma discharge. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2106054','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2106054">ELECTRON MICROSCOPIC OBSERVATION OF SPECIMENS UNDER CONTROLLED GAS PRESSURE</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Heide, Hans Gunther 1962-01-01 A technique for encasing specimens in a thin gas layer during their observation in the Siemens Elmiskop I is described. All gases can be employed at pressures up to one atmosphere. Destruction of specimens can occur in the beam; all organic specimens are particularly liable to decompose. The conditions under which this can be avoided are given. A useful application of the technique allows one to prevent specimens from drying out, as they normally do in vacuum. A further application uses the controlled removal of carbon for thinning organic layers and for selective etching of organic materials. PMID:13905967 </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1994JGR....9921511B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1994JGR....9921511B">Pickup protons and pressure-balanced structures: Voyager 2 observations in merged interaction regions near 35 AU</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Burlaga, L. F.; Ness, N. F.; Belcher, J. W.; Szabo, A.; Isenberg, P. A.; Lee, M. A. 1994-11-01 Five pressure-balanced structures, each with a scale of the order of a few hundredths of an astonomical unit (AU), were identified in two merged interaction regions (MIRs) near 35 AU in the Voyager 2 plasma and magnetic field data. They include a tangential discontinuity, simple and complex magnetic holes, slow correlated variations among the plasma and magnetic field parameters, and complex uncorrelated variations among the parameters. The changes in the magnetic pressure in these events are balanced by changes in the pressure of interstellar pickup protons. Thus the pickup protons probably play a major role in the dynamics of the MIRs. The solar wind proton and electron pressures are relatively unimportant in the MIRs at 35 AU and beyond. The region near 35 AU is transition region: the Sun is the source of the magnetic field, but the interstellar medium in source of pickups protons. Relative to the solar wind proton guyroadius, the thicknesses of the discontinuities and simple magnetic holes observed near 35 AU are at least an order of magnitude greater than those observed at 1 AU. However, the thicknesses of the tangential discontinuity and simple magnetic holes observed near 35 AU (in units of the pickup proton Larmor radius) are comparable to those observed at 1 AU (in units of the solar wind proton gyroradius). Thus the gyroradius of interstellar pickup protons controls the thickness of current sheets near 35 AU. We determine the interstellar pickup proton pressure in the PBSs. Using a model for the pickup proton temperature, we estimate that the average interstellar pickup proton pressure, temperature, and density in the MIRs at 35 AU are (0.53 +/- 0.14) x 10-12 erg/cu cm, (5.8 +/- 0.4) x 106 K and (7 +/- 2) x 10-4/cu cm. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.fs.usda.gov/treesearch/pubs/24784','TREESEARCH'); return false;" href="https://www.fs.usda.gov/treesearch/pubs/24784">Elk and mule deer responses to variation in hunting pressure.</a> <a target="_blank" href="http://www.fs.usda.gov/treesearch/">Treesearch</a> Bruce K. Johnson; Alan A. Ager; James H. Noyes; Norm Cimon 2004-01-01 Hunting can exert a variety of effects on both targeted and nontargeted ungulates, and animals either run or hide in response to hunting pressure. If animals successfully elude hunters by running, the energetic cost may deplete fat reserves needed for survival during winter in temperate regions. If animals successfully elude hunters by hiding, there may be an energetic... </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19930053892&hterms=laser+gold&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Dlaser%2Bgold','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19930053892&hterms=laser+gold&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Dlaser%2Bgold">Response of a piezoelectric pressure transducer to IR laser beam impingement</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Smith, William C.; Leiweke, Robert J.; Beeson, Harold 1992-01-01 The non-pressure response of a PCB Model 113A transducer to a far infrared radiation impulse from a carbon dioxide laser was investigated. Incident radiation was applied both to the bare transducer diaphragm and to coated diaphragms. Coatings included two common ablative materials and a reflective gold coating. High-flux radiation impulses induced an immediate brief negative output followed by a longer-duration positive output. Both timing and amplitude of the responses will be discussed, and the effects of coatings will be compared. Bursts of blackbody radiation from a 1500 K source produced qualitatively similar responses. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017APS..DFDD30003L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017APS..DFDD30003L">On the Unsteadiness of a Transitional Shock Wave-Boundary Layer Interaction Using Fast-Response Pressure-Sensitive Paint</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Lash, E. Lara; Schmisseur, John 2017-11-01 Pressure-sensitive paint has been used to evaluate the unsteady dynamics of transitional and turbulent shock wave-boundary layer interactions generated by a vertical cylinder on a flat plate in a Mach 2 freestream. The resulting shock structure consists of an inviscid bow shock that bifurcates into a separation shock and trailing shock. The primary features of interest are the separation shock and an upstream influence shock that is intermittently present in transitional boundary layer interactions, but not observed in turbulent interactions. The power spectral densities, frequency peaks, and normalized wall pressures are analyzed as the incoming boundary layer state changes from transitional to fully turbulent, comparing both centerline and outboard regions of the interaction. The present study compares the scales and frequencies of the dynamics of the separation shock structure in different boundary layer regimes. Synchronized high-speed Schlieren imaging provides quantitative statistical analyses as well as qualitative comparisons to the fast-response pressure sensitive paint measurements. Materials based on research supported by the U.S. Office of Naval Research under Award Number N00014-15-1-2269. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19870035436&hterms=hmx&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Dhmx','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19870035436&hterms=hmx&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Dhmx">Pressure-coupled combustion response model for solid propellants based on Zeldovich-Novozhilov approach</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Harstad, K. G.; Strand, L. D. 1987-01-01 An exact analytical solution is given to the problem of long-time propellant thermal response to a specified pressure oscillation. Coupling to the gas phase is made using the quasisteady Zeldovich-Novozhilov approximation. Explicit linear and lowest order (quadratic) nonlinear expressions for propellant response are obtained from the implicit nonlinear solutions. Using these expressions, response curves are presented for an ammonium perchlorate composite propellant and HMX monopropellant. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19980019023&hterms=displacement+internal&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Ddisplacement%2Binternal','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19980019023&hterms=displacement+internal&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Ddisplacement%2Binternal">Nonlinear Response of Thin Cylindrical Shells with Longitudinal Cracks and Subjected to Internal Pressure and Axial compression Loads</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Starnes, James H.; Rose, Cheryl A. 1998-01-01 The results of an analytical study of the nonlinear response of a thin unstiffened aluminum cylindrical shell with a longitudinal crack are presented. The shell is analyzed with a nonlinear shell analysis code that maintains the shell in a nonlinear equilibrium state while the crack is grown. The analysis accurately accounts for global and local structural response phenomena. Results are presented for internal pressure, axial compression, and combined internal pressure and axial compression loads. The effects of varying crack length on the nonlinear response of the shell subjected to internal pressure are described. The effects of varying crack length on the prebuckling, buckling and postbuckling responses of the shell subjected to axial compression, and subjected to combined internal pressure and axial compression are also described. The results indicate that the nonlinear interaction between the in-plane stress resultants and the out-of-plane displacements near a crack can significantly affect the structural response of the shell. The results also indicate that crack growth instabilities and shell buckling instabilities can both affect the response of the shell as the crack length is increased. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27856342','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27856342">Angiotensin II AT1 receptors mediate neuronal sensitization and sustained blood pressure response induced by a single injection of amphetamine.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Marchese, N A; Paz, M C; Caeiro, X; Dadam, F M; Baiardi, G; Perez, M F; Bregonzio, C 2017-01-06 A single exposure to amphetamine induces neurochemical sensitization in striatal areas. The neuropeptide angiotensin II, through AT 1 receptors (AT 1 -R) activation, is involved in these responses. However, amphetamine-induced alterations can be extended to extra-striatal areas involved in blood pressure control and their physiological outcomes. Our aim for the present study was to analyze the possible role for AT 1 -R in these events using a two-injection protocol and to further characterize the proposed AT 1 -R antagonism protocol. Central effect of orally administered AT 1 -R blocker (Candesartan, 3mg/kg p.o.×5days) in male Wistar rats was analyzed by spontaneous activity of neurons within locus coeruleus. In another group of animals pretreated with the AT 1 -R blocker or vehicle, sensitization was achieved by a single administration of amphetamine (5mg/kg i.p. - day 6) followed by a 3-week period off drug. On day 27, after receiving an amphetamine challenge (0.5mg/kg i.p.), we evaluated: (1) the sensitized c-Fos expression in locus coeruleus (LC), nucleus of the solitary tract (NTS), caudal ventrolateral medulla (A1) and central amygdala (CeAmy); and (2) the blood pressure response. AT 1 -R blockade decreased LC neurons' spontaneous firing rate. Moreover, sensitized c-Fos immunoreactivity in TH+neurons was found in LC and NTS; and both responses were blunted by the AT 1 -R blocker pretreatment. Meanwhile, no differences were found neither in CeAmy nor A1. Sensitized blood pressure response was observed as sustained changes in mean arterial pressure and was effectively prevented by AT 1 -R blockade. Our results extend AT 1 -R role in amphetamine-induced sensitization over noradrenergic nuclei and their cardiovascular output. Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015APS..SHK.K6001V','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015APS..SHK.K6001V">Compaction and High-Pressure Response of Granular Tantalum Oxide</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Vogler, Tracy; Root, Seth; Knudson, Marcus; Thornhill, Tom; Reinhart, William 2015-06-01 The dynamic behavior of nearly fully-dense and porous tantalum oxide (Ta2O5) is studied. Two particle morphologies are used to obtain two distinct initial tap densities, which correspond to approximately 40% and 15% of crystalline density. The response is characterized from low pressures, which result in incomplete compaction, to very high pressures where the thermal component of the EOS dominates. Issues related to a possible phase transformation along the Hugoniot and to establishing reasonable error bars on the experimental data will be discussed. The suitability of continuum and mesoscale models to capture the experimental results will be examined. Sandia National Laboratories is a multi-program laboratory operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Company, for the U.S. Department of Energy's National Nuclear Security Administration under Contract DE-AC04-94AL85000. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014PhRvE..90d2725D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014PhRvE..90d2725D">High-pressure dynamics of hydrated protein in bioprotective trehalose environment</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Diallo, S. O.; Zhang, Q.; O'Neill, H.; Mamontov, E. 2014-10-01 We present a pressure-dependence study of the dynamics of lysozyme protein powder immersed in deuterated α ,α -trehalose environment via quasielastic neutron scattering (QENS). The goal is to assess the baroprotective benefits of trehalose on biomolecules by comparing the findings with those of a trehalose-free reference study. While the mean-square displacement of the trehalose-free protein (hydrated to dD2O≃ 40 w%) as a whole, is reduced by increasing pressure, the actual observable relaxation dynamics in the picoseconds to nanoseconds time range remains largely unaffected by pressure—up to the maximum investigated pressure of 2.78(2) Kbar. Our observation is independent of whether or not the protein is mixed with the deuterated sugar. This suggests that the hydrated protein's conformational states at atmospheric pressure remain unaltered by hydrostatic pressures, below 2.78 Kbar. We also found the QENS response to be totally recoverable after ambient pressure conditions are restored. Small-angle neutron diffraction measurements confirm that the protein-protein correlation remains undisturbed. We observe, however, a clear narrowing of the QENS response as the temperature is decreased from 290 to 230 K in both cases, which we parametrize using the Kohlrausch-Williams-Watts stretched exponential model. Only the fraction of protons that are immobile on the accessible time window of the instrument, referred to as the elastic incoherent structure factor, is observably sensitive to pressure, increasing only marginally but systematically with increasing pressure. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://rosap.ntl.bts.gov/view/dot/959','DOTNTL'); return false;" href="https://rosap.ntl.bts.gov/view/dot/959">Pavement testing facility : effects of tire pressure on flexible pavement response performance</a> <a target="_blank" href="http://ntlsearch.bts.gov/tris/index.do">DOT National Transportation Integrated Search</a> 1989-08-01 The effects of tire pressure on flexible pavement response and performance were evaluated using data from the first phase of research at the Federal Highway Administration's Pavement Testing Facility. The Accelerated Loading Facility testing machine ... </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li class="active">10</li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_11" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li class="active">11</li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="201"> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2144150','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2144150">Pressure response of protein backbone structure. Pressure-induced amide 15N chemical shifts in BPTI.</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Akasaka, K.; Li, H.; Yamada, H.; Li, R.; Thoresen, T.; Woodward, C. K. 1999-01-01 The effect of pressure on amide 15N chemical shifts was studied in uniformly 15N-labeled basic pancreatic trypsin inhibitor (BPTI) in 90%1H2O/10%2H2O, pH 4.6, by 1H-15N heteronuclear correlation spectroscopy between 1 and 2,000 bar. Most 15N signals were low field shifted linearly and reversibly with pressure (0.468 +/- 0.285 ppm/2 kbar), indicating that the entire polypeptide backbone structure is sensitive to pressure. A significant variation of shifts among different amide groups (0-1.5 ppm/2 kbar) indicates a heterogeneous response throughout within the three-dimensional structure of the protein. A tendency toward low field shifts is correlated with a decrease in hydrogen bond distance on the order of 0.03 A/2 kbar for the bond between the amide nitrogen atom and the oxygen atom of either carbonyl or water. The variation of 15N shifts is considered to reflect site-specific changes in phi, psi angles. For beta-sheet residues, a decrease in psi angles by 1-2 degrees/2 kbar is estimated. On average, shifts are larger for helical and loop regions (0.553 +/- 0.343 and 0.519 +/- 0.261 ppm/2 kbar, respectively) than for beta-sheet (0.295 +/- 0.195 ppm/2 kbar), suggesting that the pressure-induced structural changes (local compressibilities) are larger in helical and loop regions than in beta-sheet. Because compressibility is correlated with volume fluctuation, the result is taken to indicate that the volume fluctuation is larger in helical and loop regions than in beta-sheet. An important aspect of the volume fluctuation inferred from pressure shifts is that they include motions in slower time ranges (less than milliseconds) in which many biological processes may take place. PMID:10548039 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29886423','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29886423">Upward Shift and Steepening of the Blood Pressure Response to Exercise in Hypertensive Subjects at High Altitude.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Caravita, Sergio; Faini, Andrea; Baratto, Claudia; Bilo, Grzegorz; Macarlupu, Josè Luis; Lang, Morin; Revera, Miriam; Lombardi, Carolina; Villafuerte, Francisco C; Agostoni, Piergiuseppe; Parati, Gianfranco 2018-06-09 Acute exposure to high-altitude hypobaric hypoxia induces a blood pressure rise in hypertensive humans, both at rest and during exercise. It is unclear whether this phenomenon reflects specific blood pressure hyperreactivity or rather an upward shift of blood pressure levels. We aimed at evaluating the extent and rate of blood pressure rise during exercise in hypertensive subjects acutely exposed to high altitude, and how these alterations can be counterbalanced by antihypertensive treatment. Fifty-five subjects with mild hypertension, double-blindly randomized to placebo or to a fixed-dose combination of an angiotensin-receptor blocker (telmisartan 80 mg) and a calcium-channel blocker (nifedipine slow release 30 mg), performed a cardiopulmonary exercise test at sea level and after the first night's stay at 3260 m altitude. High-altitude exposure caused both an 8 mm Hg upward shift ( P <0.01) and a 0.4 mm Hg/mL/kg per minute steepening ( P <0.05) of the systolic blood pressure/oxygen consumption relationship during exercise, independent of treatment. Telmisartan/nifedipine did not modify blood pressure reactivity to exercise (blood pressure/oxygen consumption slope), but downward shifted ( P <0.001) the relationship between systolic blood pressure and oxygen consumption by 26 mm Hg, both at sea level and at altitude. Muscle oxygen delivery was not influenced by altitude exposure but was higher on telmisartan/nifedipine than on placebo ( P <0.01). In hypertensive subjects exposed to high altitude, we observed a hypoxia-driven upward shift and steepening of the blood pressure response to exercise. The effect of the combination of telmisartan/nifedipine slow release outweighed these changes and was associated with better muscle oxygen delivery. URL: http://www.clinicaltrials.gov. Unique identifier: NCT01830530. © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/15895595','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/15895595">The effect of ambient pressure on well chamber response: Monte Carlo calculated results for the HDR 1000 plus.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Bohm, Tim D; Griffin, Sheridan L; DeLuca, Paul M; DeWerd, Larry A 2005-04-01 The determination of the air kerma strength of a brachytherapy seed is necessary for effective treatment planning. Well ionization chambers are used on site at therapy clinics to determine the air kerma strength of seeds. In this work, the response of the Standard Imaging HDR 1000 Plus well chamber to ambient pressure is examined using Monte Carlo calculations. The experimental work examining the response of this chamber as well as other chambers is presented in a companion paper. The Monte Carlo results show that for low-energy photon sources, the application of the standard temperature pressure PTP correction factor produces an over-response at the reduced air densities/pressures corresponding to high elevations. With photon sources of 20 to 40 keV, the normalized PTP corrected chamber response is as much as 10% to 20% over unity for air densities/pressures corresponding to an elevation of 3048 m (10000 ft) above sea level. At air densities corresponding to an elevation of 1524 m (5000 ft), the normalized PTP-corrected chamber response is 5% to 10% over unity for these photon sources. With higher-energy photon sources (>100 keV), the normalized PTP corrected chamber response is near unity. For low-energy beta sources of 0.25 to 0.50 MeV, the normalized PTP-corrected chamber response is as much as 4% to 12% over unity for air densities/pressures corresponding to an elevation of 3048 m (10000 ft) above sea level. Higher-energy beta sources (>0.75 MeV) have a normalized PTP corrected chamber response near unity. Comparing calculated and measured chamber responses for common 103Pd- and 125I-based brachytherapy seeds show agreement to within 2.7% and 1.9%, respectively. Comparing MCNP calculated chamber responses with EGSnrc calculated chamber responses show agreement to within 3.1% at photon energies of 20 to 40 keV. We conclude that Monte Carlo transport calculations accurately model the response of this well chamber. Further, applying the standard PTP correction </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014APS..MARA26008G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014APS..MARA26008G">Observation of antiferromagnetic order collapse in the pressurized insulator LaMnPO</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Guo, Jing; Simonson, Jack; Sun, Liling; Wu, Qi; Guo, Peiwen; Zhang, Chao; Gu, Dachun; Kotliar, Gabriel; Aronson, Meigan; Zhao, Zhongxian 2014-03-01 The emergence of superconductivity in the iron pnictide or cuprate high temperature superconductors usually accompanies the suppression of a long-ranged antiferromagnetic (AFM) order state in a corresponding parent compound by doping or pressurizing. A great deal of effort by doping has been made to find superconductivity in Mn-based compounds, which are thought to bridge the gap between the two families of high temperature superconductors, but the AFM order was not successfully suppressed. Here we report the first observations of the pressure-induced elimination of long-ranged AFM order at ~ 34 GPa and a crossover from an AFM insulating to an AFM metallic state at ~ 20 GPa in LaMnPO single crystals that are iso-structural to the LaFeAsO superconductor by in-situ high pressure resistance and ac susceptibility measurements. These findings are of importance to explore potential superconductivity in Mn-based compounds and to shed new light on the underlying mechanism of high temperature superconductivity. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013NatSR...3E2555G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013NatSR...3E2555G">Observation of antiferromagnetic order collapse in the pressurized insulator LaMnPO</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Guo, Jing; Simonson, J. W.; Sun, Liling; Wu, Qi; Gao, Peiwen; Zhang, Chao; Gu, Dachun; Kotliar, Gabriel; Aronson, Meigan; Zhao, Zhongxian 2013-08-01 The emergence of superconductivity in the iron pnictide or cuprate high temperature superconductors usually accompanies the suppression of a long-ranged antiferromagnetic (AFM) order state in a corresponding parent compound by doping or pressurizing. A great deal of effort by doping has been made to find superconductivity in Mn-based compounds, which are thought to bridge the gap between the two families of high temperature superconductors, but the AFM order was not successfully suppressed. Here we report the first observations of the pressure-induced elimination of long-ranged AFM order at ~ 34 GPa and a crossover from an AFM insulating to an AFM metallic state at ~ 20 GPa in LaMnPO single crystals that are iso-structural to the LaFeAsO superconductor by in-situ high pressure resistance and ac susceptibility measurements. These findings are of importance to explore potential superconductivity in Mn-based compounds and to shed new light on the underlying mechanism of high temperature superconductivity. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23989921','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23989921">Observation of antiferromagnetic order collapse in the pressurized insulator LaMnPO.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Guo, Jing; Simonson, J W; Sun, Liling; Wu, Qi; Gao, Peiwen; Zhang, Chao; Gu, Dachun; Kotliar, Gabriel; Aronson, Meigan; Zhao, Zhongxian 2013-01-01 The emergence of superconductivity in the iron pnictide or cuprate high temperature superconductors usually accompanies the suppression of a long-ranged antiferromagnetic (AFM) order state in a corresponding parent compound by doping or pressurizing. A great deal of effort by doping has been made to find superconductivity in Mn-based compounds, which are thought to bridge the gap between the two families of high temperature superconductors, but the AFM order was not successfully suppressed. Here we report the first observations of the pressure-induced elimination of long-ranged AFM order at ~ 34 GPa and a crossover from an AFM insulating to an AFM metallic state at ~ 20 GPa in LaMnPO single crystals that are iso-structural to the LaFeAsO superconductor by in-situ high pressure resistance and ac susceptibility measurements. These findings are of importance to explore potential superconductivity in Mn-based compounds and to shed new light on the underlying mechanism of high temperature superconductivity. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=accountability&id=EJ1132107','ERIC'); return false;" href="https://eric.ed.gov/?q=accountability&id=EJ1132107">Orienting Schools toward Equity: Subgroup Accountability Pressure and School-Level Responses</a> <a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a> Garver, Rachel 2017-01-01 This article examines school-level responses to subgroup accountability pressure through an ethnographic case study of a school cited for failing to make adequate yearly progress for student subgroups. Concerns about the calculations and measures used to derive the citation and reservations about acting on accountability data delegitimized the… </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28460504','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28460504">[The predictive value of dynamic arterial elastance in arterial pressure response after norepinephrine dosage reduction in patients with septic shock].</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Liang, F M; Yang, T; Dong, L; Hui, J J; Yan, J 2017-05-01 Objective: To assess whether dynamic arterial elastance(Ea(dyn))can be used to predict the reduction of arterial pressure after decreasing norepinephrine (NE) dosage in patients with septic shock. Methods: A prospective observational cohort study was conducted. Thirty-two patients with septic shock and mechanical ventilationwere enrolledfrom January 2014 to December 2015 in ICU of Wuxi People's Hospital of Nanjing Medical University. Hemodynamic parameters were recorded by pulse contour cardiac output(PiCCO)monitoring technology before and after decreasing norepinephrine dosage. Ea(dyn) was defined as the ratio of pulse pressure variation (PPV) to stroke volume variation (SVV). Mean arterial pressure(MAP) variation was calculated after decreasing the dose of NE. Response was defined as a ≥15% decrease of MAP. AUC was plotted to assess the value of Ea(dyn) in predicting MAP response. Results: A total of 32 patients were enrolled in our study, with 13 responding to NE dose decrease where as the other 19 did not. Ea(dyn) was lower in responders than in nonresponders (0.77±0.13 vs 1.09±0.31, P <0.05). Baseline Ea(dyn) was positively correlated with systolic blood pressure variation, diastolic blood pressure variation, systemic vascular resistance variation and MAP variation( r =0.621, P =0.000; r =0.735, P =0.000; r =0.756, P =0.000; r =0.568, P =0.000 respectively). However, stoke volume variation, baseline level of systemic vascular resistance and NE baseline dose were not correlated with Ea(dyn) baseline value( r =0.264, P =0.076; r =0.078, P =0.545; r =0.002, P =0.987 respectively). Ea(dyn)≤0.97 predicted a decrease of MAP when decreasing NE dose, with an area under the receiver-operating characteristic curve of 0.85.The sensitivity was 100.0% and specificity was 73.7%. Conclusions: In septic shock patients treated with NE, Ea(dyn) is an index to predict the decrease of arterial pressure in response to NE dose reduction. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/1170103-co2-exposure-pressure-impacts-metabolism-stress-responses-model-sulfate-reducing-bacterium-desulfovibrio-vulgaris-strain-hildenborough','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/1170103-co2-exposure-pressure-impacts-metabolism-stress-responses-model-sulfate-reducing-bacterium-desulfovibrio-vulgaris-strain-hildenborough">CO2 exposure at pressure impacts metabolism and stress responses in the model sulfate-reducing bacterium Desulfovibrio vulgaris strain Hildenborough</a> <a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a> Wilkins, Michael J.; Hoyt, David W.; Marshall, Matthew J. Geologic carbon dioxide (CO2) sequestration drives physical and geochemical changes in deep subsurface environments that impact indigenous microbial activities. The combined effects of pressurized CO2 on a model sulfate-reducing microorganism, Desulfovibrio vulgaris, have been assessed using a suite of genomic and kinetic measurements. Novel high-pressure NMR time-series measurements using 13C-lactate were used to track D. vulgaris metabolism. We identified cessation of respiration at CO2 pressures of 10 bar, 25 bar, 50 bar, and 80 bar. Concurrent experiments using N2 as the pressurizing phase had no negative effect on microbial respiration, as inferred from reduction of sulfate to sulfide. Complementary pressurizedmore » batch incubations and fluorescence microscopy measurements supported NMR observations, and indicated that non-respiring cells were mostly viable at 50 bar CO2 for at least four hours, and at 80 bar CO2 for two hours. The fraction of dead cells increased rapidly after four hours at 80 bar CO2. Transcriptomic (RNA-Seq) measurements on mRNA transcripts from CO2-incubated biomass indicated that cells up-regulated the production of certain amino acids (leucine, isoleucine) following CO2 exposure at elevated pressures, likely as part of a general stress response. Evidence for other poorly understood stress responses were also identified within RNA-Seq data, suggesting that while pressurized CO2 severely limits the growth and respiration of D. vulgaris cells, biomass retains intact cell membranes at pressures up to 80 bar CO2. Together, these data show that geologic sequestration of CO2 may have significant impacts on rates of sulfate reduction in many deep subsurface environments where this metabolism is a key respiratory process.« less </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014SPIE.9157E..5DR','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014SPIE.9157E..5DR">Intradiscal pressure variation under spontaneous ventilation</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Roriz, Paulo; Ferreira, J.; Potes, J. C.; Oliveira, M. T.; Santos, J. L.; Simões, J. A.; Frazão, O. 2014-05-01 The pressure measured in the intervertebral discs is a response to the loads acting on the spine. External loads, such as the reaction forces resulting from locomotion, manual handling and collisions are probably the most relevant in studying spine trauma. However, the physiological functions such as breathing and hearth rate also participate in subtle variations of intradiscal pressure that can be observed only in vivo at resting. Present work is an effort to measure the effect of breathing on intradiscal pressure of an anesthetized sheep. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28802909','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28802909">Variable prognostic value of blood pressure response to exercise.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Kato, Yuko; Suzuki, Shinya; Uejima, Tokuhisa; Semba, Hiroaki; Yamashita, Takeshi 2018-01-01 The aim of this study was to evaluate the impact of patient background including exercise capacity on the relationship between the blood pressure (BP) response to exercise and prognosis in patients visiting a cardiovascular hospital. A total of 2134 patients who were referred to our hospital underwent symptom-limited maximal cardiopulmonary exercise testing, and were followed through medical records and mail. The BP response to exercise was defined as the difference between peak and rest systolic BP. The end point was set as cardiovascular events including cardiovascular death, acute coronary syndrome, hospitalization for heart failure, and cerebral infarction. During a median follow-up period of 3 years, 179 (8%) patients reached the end point (2.5%/year). Multivariate analysis showed that BP response was independently and negatively associated with the occurrence of the end point. This prognostic significance of BP response was consistent regardless of left ventricular ejection fraction, renal function, presence of heart failure symptoms, the presence of organic heart disease, and hypertension. However, peak VO 2 showed a significant interaction with the effects of BP response on the end point, suggesting that the prognostic value of BP response was limited in patients with preserved exercise capacity. The role of BP response to exercise as the predictor depends on exercise capacity of each patient. Copyright © 2017 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19913544','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19913544">Attenuated hypertrophic response to pressure overload in a lamin A/C haploinsufficiency mouse.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Cupesi, Mihaela; Yoshioka, Jun; Gannon, Joseph; Kudinova, Anastacia; Stewart, Colin L; Lammerding, Jan 2010-06-01 Inherited mutations cause approximately 30% of all dilated cardiomyopathy cases, with autosomal dominant mutations in the LMNA gene accounting for more than one third of these. The LMNA gene encodes the nuclear envelope proteins lamins A and C, which provide structural support to the nucleus and also play critical roles in transcriptional regulation. Functional deletion of a single allele is sufficient to trigger dilated cardiomyopathy in humans and mice. However, whereas Lmna(-/-) mice develop severe muscular dystrophy and dilated cardiomyopathy and die by 8 weeks of age, heterozygous Lmna(+/-) mice have a much milder phenotype, with changes in ventricular function and morphology only becoming apparent at 1 year of age. Here, we studied 8- to 20-week-old Lmna(+/-) mice and wild-type littermates in a pressure overload model to examine whether increased mechanical load can accelerate or exacerbate myocardial dysfunction in the heterozygotes. While overall survival was similar between genotypes, Lmna(+/-) animals had a significantly attenuated hypertrophic response to pressure overload as evidenced by reduced ventricular mass and myocyte size. Analysis of pressure overload-induced transcriptional changes suggested that the reduced hypertrophy in the Lmna(+/-) mice was accompanied by impaired activation of the mechanosensitive gene Egr-1. In conclusion, our findings provide further support for a critical role of lamins A and C in regulating the cellular response to mechanical stress in cardiomyocytes and demonstrate that haploinsufficiency of lamins A and C alone is sufficient to alter hypertrophic responses and cardiac function in the face of pressure overload in the heart. (c) 2009 Elsevier Ltd. All rights reserved. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2866774','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2866774">Attenuated hypertrophic response to pressure overload in a lamin A/C haploinsufficiency mouse</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Cupesi, Mihaela; Yoshioka, Jun; Gannon, Joseph; Kudinova, Anastacia; Stewart, Colin L.; Lammerding, Jan 2009-01-01 Inherited mutations cause approximately 30% of all dilated cardiomyopathy cases, with autosomal dominant mutations in the LMNA gene accounting for more than one third of these. The LMNA gene encodes the nuclear envelope proteins lamins A and C, which provide structural support to the nucleus and also play critical roles in transcriptional regulation. Functional deletion of a single allele is sufficient to trigger dilated cardiomyopathy in humans and mice. However, whereas Lmna−/− mice develop severe muscular dystrophy and dilated cardiomyopathy and die by 8 weeks of age, heterozygous Lmna+/− mice have a much milder phenotype, with changes in ventricular function and morphology only becoming apparent at one year of age. Here, we studied 8 to 20 week old Lmna+/− mice and wild-type littermates in a pressure overload model to examine whether increased mechanical load can accelerate or exacerbate myocardial dysfunction in the heterozygotes. While overall survival was similar between genotypes, Lmna+/− animals had a significantly attenuated hypertrophic response to pressure overload as evidenced by reduced ventricular mass and myocyte size. Analysis of pressure-overload induced transcriptional changes suggested that the reduced hypertrophy in the Lmna+/− mice was accompanied by impaired activation of the mechanosensitive gene Egr-1. In conclusion, our findings provide further support for a critical role of lamins A and C in regulating the cellular response to mechanical stress in cardiomyocytes and demonstrate that haploinsufficiency of lamins A and C alone is sufficient to alter hypertrophic responses and cardiac function in the face of pressure overload in the heart. PMID:19913544 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/11082161','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/11082161">NOS3 Glu298Asp genotype and blood pressure response to endurance training: the HERITAGE family study.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Rankinen, T; Rice, T; Pérusse, L; Chagnon, Y C; Gagnon, J; Leon, A S; Skinner, J S; Wilmore, J H; Rao, D C; Bouchard, C 2000-11-01 Endothelium-dependent vasodilation is a mechanism that may affect blood pressure response to endurance training. Because NO plays a central role in this process, the endothelial NO synthase gene is a good candidate for the regulation of exercise blood pressure. We investigated the associations between an endothelial NO synthase gene polymorphism (Glu298Asp) and endurance training-induced changes in resting and submaximal exercise blood pressure in 471 white subjects of the HERITAGE Family Study. Two submaximal exercise tests at 50 W were conducted both before and after a 20-week endurance training program. Steady-state exercise blood pressure was measured twice in each test with an automated unit. The Glu298Asp polymorphism was typed with a PCR-based method and digestion with BAN:II. Both systolic and diastolic blood pressure at 50 W decreased in response to the training program, whereas resting blood pressure remained unchanged. The decrease in diastolic blood pressure at 50 W was greater (P=0.0005, adjusted for age, gender, baseline body mass index, and baseline diastolic blood pressure at 50 W) in the Glu/Glu homozygotes (4.4 [SEM 0.4] mm Hg, n=187) than in the heterozygotes (3.1 [0.4] mm Hg, n=213) and the Asp/Asp homozygotes (1.3 [0.7] mm Hg, n=71). The genotype accounted for 2.3% of the variance in diastolic blood pressure at 50 W training response. Both the Glu298 homozygotes and the heterozygotes had a greater (P=0.013) training-induced reduction in rate-pressure product at 50 W than the Asp298 homozygotes. These data suggest that DNA sequence variation in the endothelial NO synthase gene locus is associated with the endurance training-induced decreases in submaximal exercise diastolic blood pressure and rate-pressure product in sedentary normotensive white subjects. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19930071677&hterms=transverse+study&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D60%26Ntt%3Dtransverse%2Bstudy','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19930071677&hterms=transverse+study&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D60%26Ntt%3Dtransverse%2Bstudy">Effect of boundary conditions and panel geometry on the response of laminated panels subjected to transverse pressure loads</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Jegley, Dawn C. 1993-01-01 The behavior of thin laminated flat and curved panels subjected to transverse pressure and inplane loads is considered. The effects of panel geometry, boundary conditions and laminate stacking sequence on the response of panels subjected to transverse pressure loads up to 12.4 N/sq cm is presented. The response of thin laminated panels is evaluated analytically and selected results are compared with test data. A parametric study of the deformation and strain responses of panels with radius of curvature ranging from 20 to 305 cm is presented. The combination of inplane tensile and pressure loads is also considered. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5861553','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5861553">Integrative Blood Pressure Response to Upright Tilt Post Renal Denervation</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Howden, Erin J.; East, Cara; Lawley, Justin S.; Stickford, Abigail S.L.; Verhees, Myrthe; Fu, Qi 2017-01-01 Abstract BACKGROUND Whether renal denervation (RDN) in patients with resistant hypertension normalizes blood pressure (BP) regulation in response to routine cardiovascular stimuli such as upright posture is unknown. We conducted an integrative study of BP regulation in patients with resistant hypertension who had received RDN to characterize autonomic circulatory control. METHODS Twelve patients (60 ± 9 [SD] years, n = 10 males) who participated in the Symplicity HTN-3 trial were studied and compared to 2 age-matched normotensive (Norm) and hypertensive (unmedicated, HTN) control groups. BP, heart rate (HR), cardiac output (Qc), muscle sympathetic nerve activity (MSNA), and neurohormonal variables were measured supine, and 30° (5 minutes) and 60° (20 minutes) head-up-tilt (HUT). Total peripheral resistance (TPR) was calculated from mean arterial pressure and Qc. RESULTS Despite treatment with RDN and 4.8 (range, 3–7) antihypertensive medications, the RDN had significantly higher supine systolic BP compared to Norm and HTN (149 ± 15 vs. 118 ± 6, 108 ± 8 mm Hg, P < 0.001). When supine, RDN had higher HR, TPR, MSNA, plasma norepinephrine, and effective arterial elastance compared to Norm. Plasma norepinephrine, Qc, and HR were also higher in the RDN vs. HTN. During HUT, BP remained higher in the RDN, due to increases in Qc, plasma norepinephrine, and aldosterone. CONCLUSION We provide evidence of a possible mechanism by which BP remains elevated post RDN, with the observation of increased Qc and arterial stiffness, as well as plasma norepinephrine and aldosterone levels at approximately 2 years post treatment. These findings may be the consequence of incomplete ablation of sympathetic renal nerves or be related to other factors. PMID:28338768 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26562377','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26562377">Microcirculatory responses of sacral tissue in healthy individuals and inpatients on different pressure-redistribution mattresses.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Bergstrand, S; Källman, U; Ek, A-C; Engström, M; Lindgren, M 2015-08-01 The aim of this study was to explore the interaction between interface pressure, pressure-induced vasodilation, and reactive hyperaemia with different pressure-redistribution mattresses. A cross-sectional study was performed with a convenience sample of healthy young individuals, and healthy older individuals and inpatients, at a university hospital in Sweden. Blood flow was measured at depths of 1mm, 2mm, and 10mm using laser Doppler flowmetry and photoplethysmography. The blood flow, interface pressure and skin temperature were measured in the sacral tissue before, during, and after load while lying on one standard hospital mattress and three different pressure-redistribution mattresses. There were significant differences between the average sacral pressure, peak sacral pressure, and local probe pressure on the three pressure-redistribution mattresses, the lowest values found were with the visco-elastic foam/air mattress (23.5 ± 2.5mmHg, 49.3 ± 11.1mmHg, 29.2 ± 14.0mmHg, respectively). Blood flow, measured as pressure-induced vasodilation, was most affected in the visco-elastic foam/air group compared to the alternating pressure mattress group at tissue depths of 2mm (39.0% and 20.0%, respectively), and 10mm (56.9 % and 35.1%, respectively). Subjects in all three groups, including healthy 18-65 year olds, were identified with no pressure-induced vasodilation or reactive hyperaemia on any mattress (n=11), which is considered a high-risk blood flow response. Interface pressure magnitudes considered not harmful during pressure-exposure on different pressure-redistribution mattresses can affect the microcirculation in different tissue structures. Despite having the lowest pressure values compared with the other mattresses, the visco-elastic foam/air mattress had the highest proportion of subjects with decreased blood flow. Healthy young individuals were identified with the high-risk blood flow response, suggesting an innate vulnerability to pressure exposure </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27282319','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27282319">The Chemical Shift Baseline for High-Pressure NMR Spectra of Proteins.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Frach, Roland; Kibies, Patrick; Böttcher, Saraphina; Pongratz, Tim; Strohfeldt, Steven; Kurrmann, Simon; Koehler, Joerg; Hofmann, Martin; Kremer, Werner; Kalbitzer, Hans Robert; Reiser, Oliver; Horinek, Dominik; Kast, Stefan M 2016-07-18 High-pressure (HP) NMR spectroscopy is an important method for detecting rare functional states of proteins by analyzing the pressure response of chemical shifts. However, for the analysis of the shifts it is mandatory to understand the origin of the observed pressure dependence. Here we present experimental HP NMR data on the (15) N-enriched peptide bond model, N-methylacetamide (NMA), in water, combined with quantum-chemical computations of the magnetic parameters using a pressure-sensitive solvation model. Theoretical analysis of NMA and the experimentally used internal reference standard 4,4-dimethyl-4-silapentane-1-sulfonic (DSS) reveal that a substantial part of observed shifts can be attributed to purely solvent-induced electronic polarization of the backbone. DSS is only marginally responsive to pressure changes and is therefore a reliable sensor for variations in the local magnetic field caused by pressure-induced changes of the magnetic susceptibility of the solvent. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29846028','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29846028">Observers' response to facial disfigurement from head and neck cancer.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Cho, Joowon; Fingeret, Michelle Cororve; Huang, Sheng-Cheng; Liu, Jun; Reece, Gregory P; Markey, Mia K 2018-05-30 Our long-term goal is to develop a normative feedback intervention to support head and neck cancer patients in forming realistic expectations about how other people in non-social group settings will respond to their appearance. This study aimed to evaluate the relationship between observer ratings of facial disfigurement and observer ratings of emotional response when viewing photographs of faces of head and neck cancer patients. Seventy-five (75) observers rated their emotional response to each of 144 facial photographs of head and neck cancer patients using the Self-Assessment-Manikin and rated severity of facial disfigurement on a 9-point scale. Body image investment of the observers was measured using the Appearance Schemas Inventory-Revised. A standardized multiple regression model was used to assess the relationship between observer ratings of facial disfigurement and observer ratings of emotional response, taking into consideration the age and sex of the patient depicted in the stimulus photograph, as well as the age, sex, and body image investment of the observer. Observers who had a strong emotional response to a patient's facial photograph tended to rate the patient's facial disfigurement as more severe (standardized regression coefficient β = 0.328, P < 0.001). Sex and age of the observer had more influence on the rating of facial disfigurement than did the patient's demographic characteristics. Observers more invested in their own body image tended to rate the facial disfigurement as more severe. This study lays the groundwork for a normative database of emotional response to facial disfigurement. Copyright © 2018 John Wiley & Sons, Ltd. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012AGUFM.C31B0612B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012AGUFM.C31B0612B">Observations of Fabric Development in Polycrystalline Ice at Basal Pressures: Methods and Initial Results</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Breton, D. J.; Baker, I.; Cole, D. M. 2012-12-01 Understanding and predicting the flow of polycrystalline ice is crucial to ice sheet modeling and paleoclimate reconstruction from ice cores. Ice flow rates depend strongly on the fabric (i.e. the distribution of grain sizes and crystallographic orientations) which evolves over time and enhances the flow rate in the direction of applied stress. The mechanisms for fabric evolution in ice have been extensively studied at atmospheric pressures, but little work has been done to observe these processes at the high pressures experienced deep within ice sheets where long-term changes in ice rheology are expected to have significance. We conducted compressive creep tests on a 917 kg m-3 polycrystalline ice specimen at 20 MPa hydrostatic pressure, thus simulating ~2,000 m depth. Initial specimen grain orientations were random, typical grain diameters were 1.2 mm, and the applied creep stress was 0.3 MPa. Subsequent microstructural analyses on the deformed specimen and a similarly prepared, undeformed specimen allowed characterization of crystal fabric evolution under pressure. Our microstructural analysis technique simultaneously collected grain shape and size data from Scanning Electron Microscope (SEM) micrographs and obtained crystallographic orientation data via Electron BackScatter Diffraction (EBSD). Combining these measurements allows rapid analysis of the ice fabric over large numbers of grains, yielding statistically useful numbers of grain size and full c- and a-axis grain orientation data. The combined creep and microstructural data demonstrate pressure-dependent effects on the mechanical and microstructural evolution of polycrystalline ice. We discuss possible mechanisms for the observed phenomena, and future directions for hydrostatic creep testing. </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li class="active">11</li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_12" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li class="active">12</li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="221"> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013AGUFMNH52A..02W','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013AGUFMNH52A..02W">June 13, 2013 U.S. East Coast Meteotsunami: Comparing a Numerical Model With Observations</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Wang, D.; Becker, N. C.; Weinstein, S.; Whitmore, P.; Knight, W.; Kim, Y.; Bouchard, R. H.; Grissom, K. 2013-12-01 On June 13, 2013, a tsunami struck the U.S. East Coast and caused several reported injuries. This tsunami occurred after a derecho moved offshore from North America into the Atlantic Ocean. The presence of this storm, the lack of a seismic source, and the fact that tsunami arrival times at tide stations and deep ocean-bottom pressure sensors cannot be attributed to a 'point-source' suggest this tsunami was caused by atmospheric forces, i.e., a meteotsunami. In this study we attempt to reproduce the observed phenomenon using a numerical model with idealized atmospheric pressure forcing resembling the propagation of the observed barometric anomaly. The numerical model was able to capture some observed features of the tsunami at some tide stations, including the time-lag between the time of pressure jump and the time of tsunami arrival. The model also captures the response at a deep ocean-bottom pressure gauge (DART 44402), including the primary wave and the reflected wave. There are two components of the oceanic response to the propagating pressure anomaly, inverted barometer response and dynamic response. We find that the dynamic response over the deep ocean to be much smaller than the inverted barometer response. The time lag between the pressure jump and tsunami arrival at tide stations is due to the dynamic response: waves generated and/or reflected at the shelf-break propagate shoreward and amplify due to the shoaling effect. The evolution of the derecho over the deep ocean (propagation direction and intensity) is not well defined, however, because of the lack of data so the forcing used for this study is somewhat speculative. Better definition of the pressure anomaly through increased observation or high resolution atmospheric models would improve meteotsunami forecast capabilities. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4915478','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4915478">Mechanisms and pharmacogenetic signals underlying thiazide diuretics blood pressure response</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Shahin, Mohamed H; Johnson, Julie A 2016-01-01 Thiazide (TZD) diuretics are among the most commonly prescribed antihypertensives globally; however their chronic blood pressure (BP) lowering mechanism remains unclear. Herein we discuss the current evidence regarding specific mechanisms regulating the antihypertensive effects of TZDs, suggesting that TZDs act via multiple complex and interacting mechanisms, including natriuresis with short term use and direct vasodilatory effects chronically. Additionally, we review pharmacogenomics signals that have been associated with TZDs BP-response in several cohorts (i.e. NEDD4L, PRKCA, EDNRA-GNAS, and YEATS4) and discuss how these genes might be related to TZD BP-response mechanism. Understanding the association between these genes and TZD BP mechanism might facilitate the development of new drugs and therapeutic approaches based on a deeper understanding of the determinants of BP-response. PMID:26874237 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26874237','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26874237">Mechanisms and pharmacogenetic signals underlying thiazide diuretics blood pressure response.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Shahin, Mohamed H; Johnson, Julie A 2016-04-01 Thiazide (TZD) diuretics are among the most commonly prescribed antihypertensives globally; however their chronic blood pressure (BP) lowering mechanism remains unclear. Herein we discuss the current evidence regarding specific mechanisms regulating the antihypertensive effects of TZDs, suggesting that TZDs act via multiple complex and interacting mechanisms, including natriuresis with short term use and direct vasodilatory effects chronically. Additionally, we review pharmacogenomics signals that have been associated with TZDs BP-response in several cohorts (i.e. NEDD4L, PRKCA, EDNRA-GNAS, and YEATS4) and discuss how these genes might be related to TZD BP-response mechanism. Understanding the association between these genes and TZD BP mechanism might facilitate the development of new drugs and therapeutic approaches based on a deeper understanding of the determinants of BP-response. Copyright © 2016. Published by Elsevier Ltd. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29076884','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29076884">Homocysteine, visceral adiposity-related novel cardiometabolic risk factors, and exaggerated blood pressure response to the exercise treadmill test.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Türker Duyuler, Pinar; Duyuler, Serkan; Demir, Mevlüt; Uçar Elalmiş, Özgül; Güray, Ümit; İleri, Mehmet 2017-12-01 Exaggerated blood pressure response to exercise is a risk factor for the development of future hypertension. In this study, we aimed to investigate the association between homocysteine, epicardial fat thickness, nonalcoholic hepatic steatosis, and exaggerated blood pressure response to exercise. We included 44 normotensive and 40 patients with exaggerated blood pressure response to exercise who have normal resting blood pressure and without a previous diagnosis of hypertension. All patients underwent treadmill exercise test and clinical, ultrasonographic, and echocardiographic evaluation. Exaggerated blood pressure response to exercise is defined as peak exercise systolic blood pressure of at least 210 mmHg in men and at least 190 mmHg in women. Homocysteine and other biochemical parameters were determined with standardized automated laboratory tests. Mean age of all participants is 47.9±8.5 years, and 36 of 84 participants were female. The frequency of diabetes mellitus in both groups was similar (P=0.250). Homeostasis model assessment index-insulin resistance had a statistically insignificant trend to be higher in a patient with exercise hypertension (P=0.058). The nonalcoholic fatty liver was more frequent in patients with exercise hypertension (13.6 vs. 47.5%, P=0.002). Epicardial fat thickness was increased in patients with exercise hypertension (5.5±1.5 vs. 7.3±1.1 mm; P=0.001). However, homocysteine levels did not significantly differ between normotensive and exercise hypertensive patients [12.3 μmol/l (5.7-16.9 μmol/l) vs. 13 μmol/l (5.9-28.3 μmol/l); P=0.883]. In our study, homocysteine levels were not associated with exaggerated blood pressure response to exercise; however, fatty liver and epicardial fat thickness as visceral adiposity-related cardiometabolic risk factors were significantly related with exaggerated blood pressure response to exercise in patients without a previous diagnosis of hypertension. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27751909','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27751909">Microparticle formation by platelets exposed to high gas pressures - An oxidative stress response.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Bhullar, Jasjeet; Bhopale, Veena M; Yang, Ming; Sethuraman, Kinjal; Thom, Stephen R 2016-12-01 This investigation explored the mechanism for microparticles (MPs) production by human and murine platelets exposed to high pressures of inert gases. Results demonstrate that MPs production occurs via an oxidative stress response in a dose-dependent manner and follows the potency series N 2 >Ar>He. Gases with higher van der Waals volumes or polarizability such as SF 6 and N 2 O, or hydrostatic pressure, do not cause MPs production. Singlet O 2 is generated by N 2 , Ar and He, which is linked to NADPH oxidase (NOX) activity. Progression of oxidative stress involves activation of nitric oxide synthase (NOS) leading to S-nitrosylation of cytosolic actin. Exposure to gases enhances actin filament turnover and associations between short actin filaments, NOS, vasodilator-stimulated phosphoprotein (VASP), focal adhesion kinase (FAK) and Rac1. Inhibition of NOS or NOX by chemical inhibitors or using platelets from mice lacking NOS2 or the gp91phox component of NOX diminish generation of reactive species, enhanced actin polymerization and MP generation by high pressure gases. We conclude that by initiating a sequence of progressive oxidative stress responses high pressure gases cause platelets to generate MPs. Copyright © 2016 Elsevier Inc. All rights reserved. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015IJAEO..37..124N','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015IJAEO..37..124N">Satellite Earth observation data to identify anthropogenic pressures in selected protected areas</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Nagendra, Harini; Mairota, Paola; Marangi, Carmela; Lucas, Richard; Dimopoulos, Panayotis; Honrado, João Pradinho; Niphadkar, Madhura; Mücher, Caspar A.; Tomaselli, Valeria; Panitsa, Maria; Tarantino, Cristina; Manakos, Ioannis; Blonda, Palma 2015-05-01 Protected areas are experiencing increased levels of human pressure. To enable appropriate conservation action, it is critical to map and monitor changes in the type and extent of land cover/use and habitat classes, which can be related to human pressures over time. Satellite Earth observation (EO) data and techniques offer the opportunity to detect such changes. Yet association with field information and expert interpretation by ecologists is required to interpret, qualify and link these changes to human pressure. There is thus an urgent need to harmonize the technical background of experts in the field of EO data analysis with the terminology of ecologists, protected area management authorities and policy makers in order to provide meaningful, context-specific value-added EO products. This paper builds on the DPSIR framework, providing a terminology to relate the concepts of state, pressures, and drivers with the application of EO analysis. The type of pressure can be inferred through the detection of changes in state (i.e. changes in land cover and/or habitat type and/or condition). Four broad categories of changes in state are identified, i.e. land cover/habitat conversion, land cover/habitat modification, habitat fragmentation and changes in landscape connectivity, and changes in plant community structure. These categories of change in state can be mapped through EO analyses, with the goal of using expert judgement to relate changes in state to causal direct anthropogenic pressures. Drawing on expert knowledge, a set of protected areas located in diverse socio-ecological contexts and subject to a variety of pressures are analysed to (a) link the four categories of changes in state of land cover/habitats to the drivers (anthropogenic pressure), as relevant to specific target land cover and habitat classes; (b) identify (for pressure mapping) the most appropriate spatial and temporal EO data sources as well as interpretations from ecologists and field data </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29885625','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29885625">Cardiac-specific overexpression of aldehyde dehydrogenase 2 exacerbates cardiac remodeling in response to pressure overload.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Dassanayaka, Sujith; Zheng, Yuting; Gibb, Andrew A; Cummins, Timothy D; McNally, Lindsey A; Brittian, Kenneth R; Jagatheesan, Ganapathy; Audam, Timothy N; Long, Bethany W; Brainard, Robert E; Jones, Steven P; Hill, Bradford G 2018-06-01 Pathological cardiac remodeling during heart failure is associated with higher levels of lipid peroxidation products and lower abundance of several aldehyde detoxification enzymes, including aldehyde dehydrogenase 2 (ALDH2). An emerging idea that could explain these findings concerns the role of electrophilic species in redox signaling, which may be important for adaptive responses to stress or injury. The purpose of this study was to determine whether genetically increasing ALDH2 activity affects pressure overload-induced cardiac dysfunction. Mice subjected to transverse aortic constriction (TAC) for 12 weeks developed myocardial hypertrophy and cardiac dysfunction, which were associated with diminished ALDH2 expression and activity. Cardiac-specific expression of the human ALDH2 gene in mice augmented myocardial ALDH2 activity but did not improve cardiac function in response to pressure overload. After 12 weeks of TAC, ALDH2 transgenic mice had larger hearts than their wild-type littermates and lower capillary density. These findings show that overexpression of ALDH2 augments the hypertrophic response to pressure overload and imply that downregulation of ALDH2 may be an adaptive response to certain forms of cardiac pathology. Copyright © 2018. Published by Elsevier B.V. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28993450','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28993450">Blood Pressure Genetic Risk Score Predicts Blood Pressure Responses to Dietary Sodium and Potassium: The GenSalt Study (Genetic Epidemiology Network of Salt Sensitivity).</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Nierenberg, Jovia L; Li, Changwei; He, Jiang; Gu, Dongfeng; Chen, Jichun; Lu, Xiangfeng; Li, Jianxin; Wu, Xigui; Gu, C Charles; Hixson, James E; Rao, Dabeeru C; Kelly, Tanika N 2017-12-01 We examined the association between genetic risk score (GRS) for blood pressure (BP), based on single nucleotide polymorphisms identified in previous BP genome-wide association study meta-analyses, and salt and potassium sensitivity of BP among participants of the GenSalt study (Genetic Epidemiology Network of Salt Sensitivity). The GenSalt study was conducted among 1906 participants who underwent a 7-day low-sodium (51.3 mmol sodium/d), 7-day high-sodium (307.8 mmol sodium/d), and 7-day high-sodium plus potassium (60 mmol potassium/d) intervention. BP was measured 9× at baseline and at the end of each intervention period using a random zero sphygmomanometer. Associations between systolic BP (SBP), diastolic BP, and mean arterial pressure GRS and respective SBP, diastolic BP, and mean arterial pressure responses to the dietary interventions were assessed using mixed linear regression models that accounted for familial dependencies and adjusted for age, sex, field center, body mass index, and baseline BP. As expected, baseline SBP, diastolic BP, and mean arterial pressure significantly increased per quartile increase in GRS ( P =2.7×10 -8 , 9.8×10 -8 , and 6.4×10 -6 , respectively). In contrast, increasing GRS quartile conferred smaller SBP, diastolic BP, and mean arterial pressure responses to the low-sodium intervention ( P =1.4×10 -3 , 0.02, and 0.06, respectively) and smaller SBP responses to the high-sodium and potassium interventions ( P =0.10 and 0.05). In addition, overall findings were similar when examining GRS as a continuous measure. Contrary to our initial hypothesis, we identified an inverse relationship between BP GRS and salt and potassium sensitivity of BP. These data may provide novel implications on the relationship between BP responses to dietary sodium and potassium and hypertension. © 2017 American Heart Association, Inc. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23628502','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23628502">A randomized 9-month study of blood pressure and body fat responses to aerobic training versus combined aerobic and resistance training in older men.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Sousa, Nelson; Mendes, Romeu; Abrantes, Catarina; Sampaio, Jaime; Oliveira, José 2013-08-01 This randomized study evaluated the impact of different exercise training modalities on blood pressure and body fat responses in apparently healthy older men. Forty-eight elderly men (aged 65-75 years) were randomly assigned to an aerobic training group (ATG, n=15), a combined aerobic and resistance training group (CTG, n=16), or a control group (n=17). Both exercise training programs were moderate-to-vigorous intensity, three days/week for 9-months. Strength, aerobic endurance, body fat and blood pressure were measured on five different occasions. The data were analyzed using a mixed-model ANOVA, and the independence between systolic blood pressure (SBP), diastolic blood pressure (DBP) and group was tested. A significant main effect of group (p<0.001) was observed in strength and aerobic endurance, with higher performance observed in the CTG. A significant main effect of group (p<0.001) and time (p=0.029) was observed in body fat percentage, with a 2.3% decrease in CTG. A significant main effect of time was observed in SBP (p=0.005) and in DBP (p=0.011) for both ATG and CTG. Mean decreases in SBP and DBP, respectively, were 15 and 6 mmHg for ATG and 24 and 12 mmHg for CTG. There was a significant association for SBP (p=0.008) and DBP (p=0.005) in the CTG, with significant individual BP profile modifications. Both exercise-training programs reduce resting blood pressure. However, only the combined exercise training was effective at reducing body fat percentage; consequently, there were larger changes in blood pressure, which result in a significant reduction in hypertensive subjects. Copyright © 2013 Elsevier Inc. All rights reserved. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27149106','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27149106">The Impact of Experience on Affective Responses during Action Observation.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Kirsch, Louise P; Snagg, Arielle; Heerey, Erin; Cross, Emily S 2016-01-01 Perceiving others in action elicits affective and aesthetic responses in observers. The present study investigates the extent to which these responses relate to an observer's general experience with observed movements. Facial electromyographic (EMG) responses were recorded in experienced dancers and non-dancers as they watched short videos of movements performed by professional ballet dancers. Responses were recorded from the corrugator supercilii (CS) and zygomaticus major (ZM) muscles, both of which show engagement during the observation of affect-evoking stimuli. In the first part of the experiment, participants passively watched the videos while EMG data were recorded. In the second part, they explicitly rated how much they liked each movement. Results revealed a relationship between explicit affective judgments of the movements and facial muscle activation only among those participants who were experienced with the movements. Specifically, CS activity was higher for disliked movements and ZM activity was higher for liked movements among dancers but not among non-dancers. The relationship between explicit liking ratings and EMG data in experienced observers suggests that facial muscles subtly echo affective judgments even when viewing actions that are not intentionally emotional in nature, thus underscoring the potential of EMG as a method to examine subtle shifts in implicit affective responses during action observation. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5615291','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5615291">Evaluation of Different Dose-Response Models for High Hydrostatic Pressure Inactivation of Microorganisms</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> 2017-01-01 Modeling of microbial inactivation by high hydrostatic pressure (HHP) requires a plot of the log microbial count or survival ratio versus time data under a constant pressure and temperature. However, at low pressure and temperature values, very long holding times are needed to obtain measurable inactivation. Since the time has a significant effect on the cost of HHP processing it may be reasonable to fix the time at an appropriate value and quantify the inactivation with respect to pressure. Such a plot is called dose-response curve and it may be more beneficial than the traditional inactivation modeling since short holding times with different pressure values can be selected and used for the modeling of HHP inactivation. For this purpose, 49 dose-response curves (with at least 4 log10 reduction and ≥5 data points including the atmospheric pressure value (P = 0.1 MPa), and with holding time ≤10 min) for HHP inactivation of microorganisms obtained from published studies were fitted with four different models, namely the Discrete model, Shoulder model, Fermi equation, and Weibull model, and the pressure value needed for 5 log10 (P5) inactivation was calculated for all the models above. The Shoulder model and Fermi equation produced exactly the same parameter and P5 values, while the Discrete model produced similar or sometimes the exact same parameter values as the Fermi equation. The Weibull model produced the worst fit (had the lowest adjusted determination coefficient (R2adj) and highest mean square error (MSE) values), while the Fermi equation had the best fit (the highest R2adj and lowest MSE values). Parameters of the models and also P5 values of each model can be useful for the further experimental design of HHP processing and also for the comparison of the pressure resistance of different microorganisms. Further experiments can be done to verify the P5 values at given conditions. The procedure given in this study can also be extended for enzyme </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4656137','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4656137">Sex-specific effect of endothelin in the blood pressure response to acute angiotensin II in growth-restricted rats</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Intapad, Suttira; Ojeda, Norma B.; Varney, Elliott; Royals, Thomas P.; Alexander, Barbara T. 2015-01-01 The renal endothelin system contributes to sex differences in blood pressure with males demonstrating greater endothelin type-A receptor-mediated responses relative to females. Intrauterine growth restriction programs hypertension and enhanced renal sensitivity to acute angiotensin II in male growth-restricted rats. Endothelin is reported to work synergistically with angiotensin II. Thus, this study tested the hypothesis that endothelin augments the blood pressure response to acute angiotensin II in male growth-restricted rats. Systemic and renal hemodynamics were determined in response to acute angiotensin II (100 nanogram/kilogram/minute for 30 minutes) with and without the endothelin type-A receptor antagonist, ABT 627(10 nanogram/kilogram/minute for 30 minutes), in rats pretreated with enalapril (250 milligram/Liter for one week) to normalize the endogenous renin angiotensin system. Endothelin type-A receptor blockade reduced angiotensin II-mediated increases in blood pressure in male control and male growth-restricted rats. Endothelin type-A receptor blockade also abolished hyper-responsiveness to acute angiotensin II in male growth-restricted rats. Yet, blood pressure remained significantly elevated above baseline following endothelin type-A receptor blockade suggesting that factors in addition to endothelin contribute to the basic angiotensin II-induced pressor response in male rats. We also determined sex-specific effects of endothelin on acute angiotensin II-mediated hemodynamic responses. Endothelin type-A receptor blockade did not reduce acute angiotensin II-mediated increases in blood pressure in female control or growth-restricted rats, intact or ovariectomized. Thus, these data suggest that endothelin type-A receptor blockade contributes to hypersensitivity to acute angiotensin II in male growth-restricted rats and further supports the sex-specific effect of endothelin on blood pressure. PMID:26459423 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21091361','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21091361">Exaggerated blood pressure response to exercise--a new portent of masked hypertension.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Kayrak, Mehmet; Bacaksiz, Ahmet; Vatankulu, Mehmet Akif; Ayhan, Selim S; Kaya, Zeynettin; Ari, Hatem; Sonmez, Osman; Gok, Hasan 2010-01-01 Masked hypertension (MHT) is a popular entity with increased risk of developing sustained hypertension, heart attack, stroke, and death. Subjects have normal blood pressure (BP) at office but elevated values at night so it is difficult to diagnose. Exaggerated blood pressure response to exercise (EBPR) is also a predictor of future hypertension. To investigate the relationship between these two entities, we evaluated 61 normotensive subjects with EBPR. The subjects underwent 24-h ambulatory blood pressure monitoring (ABPM). The prevalence of masked hypertension among subjects with EBPR was 41%. Body mass index (BMI), non-high density lipoprotein (HDL) cholesterol, diastolic blood pressure (DBP) at peak exercise and recovery, nondipping DBP pattern, and elevated early morning average BPs were associated with masked hypertension. In multivariate logistic regression analysis, the DBP measured at peak exercise was detected as an independent predictor of MHT in subjects with EBPR. Subjects with abnormally elevated BP during exercise are prone to MHT, necessitate medical assessment and close follow-up for hypertension. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23736112','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23736112">Effects of antihypertensive drugs on central blood pressure in humans: a preliminary observation.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Agnoletti, Davide; Zhang, Yi; Borghi, Claudio; Blacher, Jacques; Safar, Michel E 2013-08-01 Central blood pressure (BP) is considered a better predictor of cardiovascular events than brachial BP. Modifications of central, beyond brachial BP, can be assessed by pressure amplification, a potential new cardiovascular risk factor. Comparison between drugs' effect on central hemodynamics has been poorly studied. Our aim was to assess the hemodynamic effect of a 12-week treatment with amlodipine 5mg, or candesartan 8mg, or indapamide sustained-release 1.5mg, in comparison with placebo. We analyzed 145 out-patients with essential hypertension in primary prevention enrolled in the Natrilix SR Versus Candesartan and Amlodipine in the Reduction of Systolic Blood Pressure in Hypertensive Patients (X-CELLENT) study, a multicenter, randomized, double-blinded, placebo-controlled trial. Arterial stiffness, central BP, pressure amplification, and wave reflection were measured by applanation tonometry. Baseline characteristics of patients were homogeneous between groups. After treatment, we found that active drugs produced similar reduction of both central and peripheral BPs, with no significant interdrug differences (all P < 0.05; excluded peripheral pulse pressure, compared with placebo). Second, amlodipine (1.9% ± 15.3%), candesartan (3.0% ± 14.6%) and indapamide (4.1% ± 14.4%) all increased pulse pressure amplification, but only indapamide was statistically different from placebo (P = 0.02). Finally, no significant changes were observed on pulse wave velocity, heart rate, and augmentation index. The 3 antihypertensive drugs similarly reduced peripheral and central BP, as compared with placebo, but a significant increase in pulse pressure amplification was obtained only with indapamide, independently of arterial stiffness modifications. 3283161 by BIOPHARMA. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29744251','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29744251">Comparison of Different Cuff Pressure Use with the Supreme Laryngeal Mask Airway on Haemodynamic Response, Seal Pressure and Postoperative Adverse Events: A Prospective Randomized Study.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Ali, Achmet; Altun, Demet; Sivrikoz, Nukhet; Yornuk, Mesut; Turgut, Namigar; Akıncı, İbrahim Özkan 2018-04-01 The Supreme™ laryngeal mask airway (SLMA) is a supra glottic airway (SGA) device that is used as an alternative to endotracheal tubes. In the present study, we aimed to compare the use of the SLMA with normal cuff pressure and low cuff pressure, primarily for haemodynamic response. In the present study, 120 patients diagnosed with hypertension and scheduled for varicose vein or inguinal hernia operation were enrolled and 99 patients finished. Using randomization, patients were divided into two groups according to cuff pressure as a low-pressure group (Group L, 45 cm H 2 O) and a normal-pressure group (Group N, 60 cm H 2 O). Demographics, Mallampati score and the type and duration of surgery, heart rate (HR), mean arterial pressure (MAP), percentage of tidal volume leakage, Ppeak, Pmean, etCO 2 , seal pressure, fibreoptic scores and postoperative adverse effects of all patients were recorded. MAP and HR values immediately and 2 minutes after SLMA insertion were significantly lower in Group L (p<0.001). In Group L and Group N, the seal pressures were 24.1±3.1 cm H 2 O and 26.2±3.9 cm H 2 O, respectively (p=0.003). Also, blood staining and sore throat occurred less frequently in Group L (p<0.05). The fibreoptic average score, insertion features and ventilation parameters were similar between the groups (p>0.05). SLMA use with a cuff pressure of 45 cm H 2 O significantly decreases haemodynamic response and post-operative side effects compared with a normal cuff pressure. Therefore, except for some specific surgeries that require higher seal pressures, we recommend the use of the SLMA with cuff pressures as low as 45 cm H 2 O. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017JPhCS.821a2005G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017JPhCS.821a2005G">Non-Ideal Compressible-Fluid Dynamics of Fast-Response Pressure Probes for Unsteady Flow Measurements in Turbomachinery</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Gori, G.; Molesini, P.; Persico, G.; Guardone, A. 2017-03-01 The dynamic response of pressure probes for unsteady flow measurements in turbomachinery is investigated numerically for fluids operating in non-ideal thermodynamic conditions, which are relevant for e.g. Organic Rankine Cycles (ORC) and super-critical CO2 applications. The step response of a fast-response pressure probe is investigated numerically in order to assess the expected time response when operating in the non-ideal fluid regime. Numerical simulations are carried out exploiting the Non-Ideal Compressible Fluid-Dynamics (NICFD) solver embedded in the open-source fluid dynamics code SU2. The computational framework is assessed against available experimental data for air in dilute conditions. Then, polytropic ideal gas (PIG), i.e. constant specific heats, and Peng-Robinson Stryjek-Vera (PRSV) models are applied to simulate the flow field within the probe operating with siloxane fluid octamethyltrisiloxane (MDM). The step responses are found to depend mainly on the speed of sound of the working fluid, indicating that molecular complexity plays a major role in determining the promptness of the measurement devices. According to the PRSV model, non-ideal effects can increase the step response time with respect to the acoustic theory predictions. The fundamental derivative of gas-dynamic is confirmed to be the driving parameter for evaluating non-ideal thermodynamic effects related to the dynamic calibration of fast-response aerodynamic pressure probes. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1664867','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1664867">Phasic negative intrathoracic pressures enhance the vascular responses to stimulation of pulmonary arterial baroreceptors in closed-chest anaesthetized dogs</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Moore, Jonathan P; Hainsworth, Roger; Drinkhill, Mark J 2004-01-01 We investigated whether the reflex responses to stimulation of pulmonary arterial baroreceptors were altered by intrathoracic pressure changes similar to those encountered during normal breathing. Dogs were anaesthetized with α-chloralose, a cardiopulmonary bypass was established, and the pulmonary trunk and its main branches as far as the first lobar arteries were vascularly isolated and perfused with venous blood. The chest was closed following connection to the perfusion circuit and pressures distending the aortic arch, carotid sinus and coronary artery baroreceptors were controlled. Changes in the descending aortic (systemic) perfusion pressure (SPP; flow constant) were used to assess changes in systemic vascular resistance. Values of SPP were plotted against mean pulmonary arterial pressure (PAP) and sigmoid functions applied. From these curves we derived the threshold pressures (corresponding to 5% of the overall response of SPP), the maximum slopes (equivalent to peak gain) and the corresponding PAP (equivalent to ‘set point’). Stimulus–response curves were compared between data obtained with intrathoracic pressure at atmospheric and with a phasic intrathoracic pressure ranging from atmospheric to around −10 mmHg (18 cycles min−1). Results were obtained from seven dogs and are given as means ±s.e.m. Compared to the values obtained when intrathoracic pressure was at atmospheric, the phasic intrathoracic pressure decreased the pulmonary arterial threshold pressure in five dogs; average change from 28.4 ± 5.9 to 19.3 ± 5.9 mmHg (P > 0.05). The inflexion pressure was significantly reduced from 37.8 ± 4.8 to 27.4 ± 4.0 mmHg (P < 0.03), but the slopes of the curves were not consistently changed. These results have shown that a phasic intrathoracic pressure, which simulates respiratory oscillations, displaces the stimulus–response curve of the pulmonary arterial baroreceptors to lower pressures so that it lies within a physiological range of </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/9413731','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/9413731">Reflex vascular responses to alterations in abdominal arterial pressure and flow in anaesthetized dogs.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Drinkhill, M J; Doe, C P; Myers, D S; Self, D A; Hainsworth, R 1997-11-01 The existence of abdominal arterial baroreceptors has long been controversial. Previously difficulties have been encountered in localizing a stimulus to abdominal arteries without affecting reflexogenic areas elsewhere. In these experiments, using anaesthetized dogs, the abdomen was vascularly isolated at the level of the diaphragm, perfused through the aorta, and drained from the inferior vena cava to a reservoir. Changes in abdominal arterial pressure were effected by changing the perfusion pump speed. During this procedure the flow back to the animal from the venous outflow reservoir was held constant. Increases and decreases in abdominal arterial pressure resulted, respectively, in decreases and increases in perfusion pressure to a vascularly isolated hind-limb and in some dogs also a forelimb. Responses were significantly larger when carotid sinus pressure was high (120-180 mmHg) than when it was low (60 mmHg). Responses were still obtained after cutting vagus, phrenic and splanchnic nerves, but were abolished by spinal cord lesion at T12. These experiments provide evidence for the existence of abdominal arterial baroreceptors. The afferent pathway for the reflex vasodilatation appears to run in the spinal cord. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29508686','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29508686">Right ventricular pressure response to exercise in adults with isolated ventricular septal defect closed in early childhood.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Moller, Thomas; Lindberg, Harald; Lund, May Brit; Holmstrom, Henrik; Dohlen, Gaute; Thaulow, Erik 2018-06-01 We previously demonstrated an abnormally high right ventricular systolic pressure response to exercise in 50% of adolescents operated on for isolated ventricular septal defect. The present study investigated the prevalence of abnormal right ventricular systolic pressure response in 20 adult (age 30-45 years) patients who underwent surgery for early ventricular septal defect closure and its association with impaired ventricular function, pulmonary function, or exercise capacity. The patients underwent cardiopulmonary tests, including exercise stress echocardiography. Five of 19 patients (26%) presented an abnormal right ventricular systolic pressure response to exercise ⩾ 52 mmHg. Right ventricular systolic function was mixed, with normal tricuspid annular plane systolic excursion and fractional area change, but abnormal tricuspid annular systolic motion velocity (median 6.7 cm/second) and isovolumetric acceleration (median 0.8 m/second2). Left ventricular systolic and diastolic function was normal at rest as measured by the peak systolic velocity of the lateral wall and isovolumic acceleration, early diastolic velocity, and ratio of early diastolic flow to tissue velocity, except for ejection fraction (median 53%). The myocardial performance index was abnormal for both the left and right ventricle. Peak oxygen uptake was normal (mean z score -0.4, 95% CI -2.8-0.3). There was no association between an abnormal right ventricular systolic pressure response during exercise and right or left ventricular function, pulmonary function, or exercise capacity. Abnormal right ventricular pressure response is not more frequent in adult patients compared with adolescents. This does not support the theory of progressive pulmonary vascular disease following closure of left-to-right shunts. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013AGUFM.A41N..04H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013AGUFM.A41N..04H">Observed and simulated changes in Antarctic sea ice and sea level pressure: anthropogenic or natural variability? (Invited)</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Hobbs, W. R. 2013-12-01 Statistically-significant changes in Antarctic sea ice cover and the overlying atmosphere have been observed over the last 30 years, but there is an open question of whether these changes are due to multi-decadal natural variability or an anthropogenically-forced response. A number of recent papers have shown that the slight increase in total sea ice cover is within the bounds of internal variability exhibited by coupled climate models in the CMIP5 suite. Modelled changes for the same time period generally show a decrease, but again with a magnitude that is within internal variability. However, in contrast to the Arctic, sea ice tends in the Antarctic are spatially highly heterogeneous, and consideration of the total ice cover may mask important regional signals. In this work, a robust ';fingerprinting' approach is used to show that the observed spatial pattern of sea ice trends is in fact outside simulated natural variability in west Antarctic, and furthermore that the CMIP5 models consistently show decreased ice cover in the Ross and Weddell Seas, sectors which in fact have an observed increase in cover. As a first step towards understanding the disagreement between models and observations, modelled sea level pressure trends are analysed using and optimal fingerprinting approach, to identify whether atmospheric deficiencies in the models can explain the model-observation discrepancy. </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li class="active">12</li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_13" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li class="active">13</li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="241"> <li> <a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol4/pdf/CFR-2010-title49-vol4-sec230-23.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol4/pdf/CFR-2010-title49-vol4-sec230-23.pdf">49 CFR 230.23 - Responsibility for general construction and safe working pressure.</a> <a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a> 2010-10-01 ... MAINTENANCE STANDARDS Boilers and Appurtenances § 230.23 Responsibility for general construction and safe... construction of the steam locomotive boilers under their control. The steam locomotive owner shall establish the safe working pressure for each steam locomotive boiler, after giving full consideration to the... </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29808709','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29808709">Differential Response of Bovine Mature Nucleus Pulposus and Notochordal Cells to Hydrostatic Pressure and Glucose Restriction.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Saggese, Taryn; Thambyah, Ashvin; Wade, Kelly; McGlashan, Susan Read 2018-05-01 Objective The nucleus pulposus of the human intervertebral disc contains 2 cell types: notochordal (NC) and mature nucleus pulposus (MNP) cells. NC cell loss is associated with disc degeneration and this process may be initiated by mechanical stress and/or nutrient deprivation. This study aimed to investigate the functional responses of NC and MNP cells to hydrostatic pressures and glucose restriction. Design Bovine MNP and NC cells were cultured in 3-dimensional alginate beads under low (0.4-0.8 MPa) and high (1.6-2.4 MPa) dynamic pressure for 24 hours. Cells were cultured in either physiological (5.5 mM) glucose media or glucose-restriction (0.55 mM) media. Finally, the combined effect of glucose restriction and high pressure was examined. Results Cell viability and notochordal phenotypic markers were not significantly altered in response to pressure or glucose restriction. MNP cells responded to low pressure with an increase in glycosaminoglycan (GAG) production while high pressure significantly decreased ACAN gene expression compared with atmospheric controls. NC cells showed no response in matrix gene expression or GAG production with either loading regime. Glucose restriction decreased NC cell TIMP-1 expression but had no effect on MNP cells. The combination of glucose restriction and high pressure only affected MNP cell gene expression, with decreased ACAN, Col2α1, and ADAMTS-5 expression. Conclusion This study shows that NC cells are more resistant to acute mechanical stresses than MNP cells and provides a strong rationale for future studies to further our understanding the role of NC cells within the disc, and the effects of long-term exposure to physical stresses. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19920050123&hterms=displacement+internal&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Ddisplacement%2Binternal','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19920050123&hterms=displacement+internal&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Ddisplacement%2Binternal">Deformation and stress response of composite laminated shells under internal pressure</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Yuan, F. G. 1991-01-01 This paper presents a theoretical study of the response of filament wound composite shells under internal pressure. Each layer of the material is generally cylindrically anisotropic. By using cylindrically anisotropic elasticity field equations and Lekhnitskii's stress functions, a system of sixth-order ordinary differential equations is obtained. The general expressions for the stresses and displacements in the laminated composite shells under internal pressure are discussed. Two composite systems, graphite/epoxy and glass/epoxy, are selected to demonstrate the influence of degree of material anisotropy and fiber orientations on the axial and induced twisting deformation. Stress distributions of (45/-45)s symmetric angle-ply fiber-reinforced laminated shells are shown to illustrate the effect of radius-to-thickness ratio. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27378270','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27378270">Molecular chaperone accumulation as a function of stress evidences adaptation to high hydrostatic pressure in the piezophilic archaeon Thermococcus barophilus.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Cario, Anaïs; Jebbar, Mohamed; Thiel, Axel; Kervarec, Nelly; Oger, Phil M 2016-07-05 The accumulation of mannosyl-glycerate (MG), the salinity stress response osmolyte of Thermococcales, was investigated as a function of hydrostatic pressure in Thermococcus barophilus strain MP, a hyperthermophilic, piezophilic archaeon isolated from the Snake Pit site (MAR), which grows optimally at 40 MPa. Strain MP accumulated MG primarily in response to salinity stress, but in contrast to other Thermococcales, MG was also accumulated in response to thermal stress. MG accumulation peaked for combined stresses. The accumulation of MG was drastically increased under sub-optimal hydrostatic pressure conditions, demonstrating that low pressure is perceived as a stress in this piezophile, and that the proteome of T. barophilus is low-pressure sensitive. MG accumulation was strongly reduced under supra-optimal pressure conditions clearly demonstrating the structural adaptation of this proteome to high hydrostatic pressure. The lack of MG synthesis only slightly altered the growth characteristics of two different MG synthesis deletion mutants. No shift to other osmolytes was observed. Altogether our observations suggest that the salinity stress response in T. barophilus is not essential and may be under negative selective pressure, similarly to what has been observed for its thermal stress response. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4932500','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4932500">Molecular chaperone accumulation as a function of stress evidences adaptation to high hydrostatic pressure in the piezophilic archaeon Thermococcus barophilus</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Cario, Anaïs; Jebbar, Mohamed; Thiel, Axel; Kervarec, Nelly; Oger, Phil M. 2016-01-01 The accumulation of mannosyl-glycerate (MG), the salinity stress response osmolyte of Thermococcales, was investigated as a function of hydrostatic pressure in Thermococcus barophilus strain MP, a hyperthermophilic, piezophilic archaeon isolated from the Snake Pit site (MAR), which grows optimally at 40 MPa. Strain MP accumulated MG primarily in response to salinity stress, but in contrast to other Thermococcales, MG was also accumulated in response to thermal stress. MG accumulation peaked for combined stresses. The accumulation of MG was drastically increased under sub-optimal hydrostatic pressure conditions, demonstrating that low pressure is perceived as a stress in this piezophile, and that the proteome of T. barophilus is low-pressure sensitive. MG accumulation was strongly reduced under supra-optimal pressure conditions clearly demonstrating the structural adaptation of this proteome to high hydrostatic pressure. The lack of MG synthesis only slightly altered the growth characteristics of two different MG synthesis deletion mutants. No shift to other osmolytes was observed. Altogether our observations suggest that the salinity stress response in T. barophilus is not essential and may be under negative selective pressure, similarly to what has been observed for its thermal stress response. PMID:27378270 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4981730','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4981730">Genetic variants in adiponectin and blood pressure responses to dietary sodium or potassium interventions: a family-based association study</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Chu, C; Wang, Y; Ren, K-y; Yan, D-y; Guo, T-s; Zheng, W-l; Yuan, Z-y; Mu, J-j 2016-01-01 Previous studies have shown that genetic factors might have an important role in blood pressure (BP) responses to dietary salt or potassium intake. The aim of this study was to assess the association of common genetic variants of the adiponectin gene with BP responses to controlled dietary sodium or potassium interventions. Subjects (n=334) from 124 families in rural areas of Northern China were recruited. After a 3-day baseline observation, participants sequentially maintained a 7-day low-sodium diet (NaCl, 3 g per day; or sodium, 51.3 mmol per day), followed by a 7-day high-sodium diet (NaCl, 18 g per day; or sodium, 307.8 mmol per day) and a 7-day high-sodium plus potassium supplementation intervention (KCl, 4.5 g per day; or potassium, 60 mmol per day). A total of seven single nucleotide polymorphisms (SNPs) in the adiponectin gene were selected as the study sites. After adjustment for multiple testing, the adiponectin SNP rs16861205 was significantly associated with the diastolic BP (DBP) response to low-salt intervention, and the DBP and mean arterial pressure (MAP) responses to high-salt intervention (P=0.028, 0.023 and 0.027, respectively). SNP rs822394 was associated with the DBP and MAP responses to low-salt intervention and the DBP response to high-salt intervention (P=0.023, 0.030 and 0.033 respectively). Meanwhile, significant association also existed between SNP rs16861194 and the systolic BP response to potassium supplementation intervention (P=0.026). In addition, SNP rs822394 was significantly associated with basal DBP after adjustment for multiple testing (P=0.033). Our study indicated that the genetic polymorphisms in the adiponectin gene are significantly associated with BP responses to dietary sodium and potassium intake. PMID:27011258 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27011258','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27011258">Genetic variants in adiponectin and blood pressure responses to dietary sodium or potassium interventions: a family-based association study.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Chu, C; Wang, Y; Ren, K-Y; Yan, D-Y; Guo, T-S; Zheng, W-L; Yuan, Z-Y; Mu, J-J 2016-09-01 Previous studies have shown that genetic factors might have an important role in blood pressure (BP) responses to dietary salt or potassium intake. The aim of this study was to assess the association of common genetic variants of the adiponectin gene with BP responses to controlled dietary sodium or potassium interventions. Subjects (n=334) from 124 families in rural areas of Northern China were recruited. After a 3-day baseline observation, participants sequentially maintained a 7-day low-sodium diet (NaCl, 3 g per day; or sodium, 51.3 mmol per day), followed by a 7-day high-sodium diet (NaCl, 18 g per day; or sodium, 307.8 mmol per day) and a 7-day high-sodium plus potassium supplementation intervention (KCl, 4.5 g per day; or potassium, 60 mmol per day). A total of seven single nucleotide polymorphisms (SNPs) in the adiponectin gene were selected as the study sites. After adjustment for multiple testing, the adiponectin SNP rs16861205 was significantly associated with the diastolic BP (DBP) response to low-salt intervention, and the DBP and mean arterial pressure (MAP) responses to high-salt intervention (P=0.028, 0.023 and 0.027, respectively). SNP rs822394 was associated with the DBP and MAP responses to low-salt intervention and the DBP response to high-salt intervention (P=0.023, 0.030 and 0.033 respectively). Meanwhile, significant association also existed between SNP rs16861194 and the systolic BP response to potassium supplementation intervention (P=0.026). In addition, SNP rs822394 was significantly associated with basal DBP after adjustment for multiple testing (P=0.033). Our study indicated that the genetic polymorphisms in the adiponectin gene are significantly associated with BP responses to dietary sodium and potassium intake. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19920059644&hterms=taylor&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAuthor-Name%26N%3D0%26No%3D90%26Ntt%3Dtaylor%2Bt%2Bb','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19920059644&hterms=taylor&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAuthor-Name%26N%3D0%26No%3D90%26Ntt%3Dtaylor%2Bt%2Bb">Atmosphere and climate studies of Mars using the Mars Observer pressure modulator infrared radiometer</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Mccleese, D. J.; Haskins, R. D.; Schofield, J. T.; Zurek, R. W.; Leovy, C. B.; Paige, D. A.; Taylor, F. W. 1992-01-01 Studies of the climate and atmosphere of Mars are limited at present by a lack of meteorological data having systematic global coverage with good horizontal and vertical resolution. The Mars Observer spacecraft in a low, nearly circular, polar orbit will provide an excellent platform for acquiring the data needed to advance significantly our understanding of the Martian atmosphere and its remarkable variability. The Mars Observer pressure modulator infrared radiometer (PMIRR) is a nine-channel limb and nadir scanning atmospheric sounder which will observe the atmosphere of Mars globally from 0 to 80 km for a full Martian year. PMIRR employs narrow-band radiometric channels and two pressure modulation cells to measure atmospheric and surface emission in the thermal infrared. PMIRR infrared and visible measurements will be combined to determine the radiative balance of the polar regions, where a sizeable fraction of the global atmospheric mass annually condenses onto and sublimes from the surface. Derived meteorological fields, including diabatic heating and cooling and the vertical variation of horizontal winds, are computed from the globally mapped fields retrieved from PMIRR data. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26707349','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26707349">Sleep homeostatic pressure and PER3 VNTR gene polymorphism influence antidepressant response to sleep deprivation in bipolar depression.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Dallaspezia, Sara; Locatelli, Clara; Lorenzi, Cristina; Pirovano, Adele; Colombo, Cristina; Benedetti, Francesco 2016-03-01 Combined Total sleep deprivation (TSD) and light therapy (LT) cause a rapid improvement in bipolar depression which has been hypothesized to be paralleled by changes in sleep homeostasis. Recent studies showed that bipolar patients had lower changes of EEG theta power after sleep and responders to antidepressant TSD+LT slept less and showed a lower increase of EEG theta power then non-responders. A polymorphism in PER3 gene has been associated with diurnal preference, sleep structure and homeostatic response to sleep deprivation in healthy subjects. We hypothesized that the individual variability in the homeostatic response to TSD could be a correlate of antidepressant response and be influenced by genetic factors. We administered three TSD+LT cycles to bipolar depressed patients. Severity of depression was rated on Hamilton Depression Rating Scale. Actigraphic recordings were performed in a group of patients. PER3 polymorphism influenced changes in total sleep time (F=2.24; p=0.024): while PER3(4/4) and PER3(4/5) patients showed a reduction in it after treatment, PER3(5/5) subjects showed an increase of about 40min, suggesting a higher homeostatic pressure. The same polymorphism influenced the change of depressive symptomatology during treatment (F=3.72; p=0.028). Sleep information was recorded till the day after the end of treatment: a longer period of observation could give more information about the possible maintenance of allostatic adaptation. A higher sleep homeostatic pressure reduced the antidepressant response to TSD+LT, while an allostatic adaptation to sleep loss was associated with better response. This process seems to be under genetic control. Copyright © 2015 Elsevier B.V. All rights reserved. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26836508','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26836508">High hydrostatic pressure influences the in vitro response to xenobiotics in Dicentrarchus labrax liver.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Lemaire, Benjamin; Mignolet, Eric; Debier, Cathy; Calderon, Pedro Buc; Thomé, Jean Pierre; Rees, Jean François 2016-04-01 Hydrostatic pressure (HP) increases by about 1 atmosphere (0.1MPa) for each ten-meter depth increase in the water column. This thermodynamical parameter could well influence the response to and effects of xenobiotics in the deep-sea biota, but this possibility remains largely overlooked. To grasp the extent of HP adaptation in deep-sea fish, comparative studies with living cells of surface species exposed to chemicals at high HP are required. We initially conducted experiments with precision-cut liver slices of a deep-sea fish (Coryphaenoides rupestris), co-exposed for 15h to the aryl hydrocarbon receptor (AhR) agonist 3-methylcholanthrene at HP levels representative of the surface (0.1MPa) and deep-sea (5-15MPa; i.e., 500-1500m depth) environments. The transcript levels of a suite of stress-responsive genes, such as the AhR battery CYP1A, were subsequently measured (Lemaire et al., 2012; Environ. Sci. Technol. 46, 10310-10316). Strikingly, the AhR agonist-mediated increase of CYP1A mRNA content was pressure-dependently reduced in C. rupestris. Here, the same co-exposure scenario was applied for 6 or 15h to liver slices of a surface fish, Dicentrarchus labrax, a coastal species presumably not adapted to high HP. Precision-cut liver slices of D. labrax were also used in 1h co-exposure studies with the pro-oxidant tert-butylhydroperoxide (tBHP) as to investigate the pressure-dependence of the oxidative stress response (i.e., reactive oxygen production, glutathione and lipid peroxidation status). Liver cells remained viable in all experiments (adenosine triphosphate content). High HP precluded the AhR agonist-mediated increase of CYP1A mRNA expression in D. labrax, as well as that of glutathione peroxidase, and significantly reduced that of heat shock protein 70. High HP (1h) also tended per se to increase the level of oxidative stress in liver cells of the surface fish. Trends to an increased resistance to tBHP were also noted. Whether the latter observation truly </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28134672','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28134672">Effects of room environment and nursing experience on clinical blood pressure measurement: an observational study.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Zhang, Meng; Zhang, Xuemei; Chen, Fei; Dong, Birong; Chen, Aiqing; Zheng, Dingchang 2017-04-01 This study aimed to examine the effects of measurement room environment and nursing experience on the accuracy of manual auscultatory blood pressure (BP) measurement. A training database with 32 Korotkoff sounds recordings from the British Hypertension Society was played randomly to 20 observers who were divided into four groups according to the years of their nursing experience (i.e. ≥10 years, 1-9 years, nursing students with frequent training, and those without any medical background; five observers in each group). All the observers were asked to determine manual auscultatory systolic blood pressure (SBP) and diastolic blood pressure (DBP) both in a quiet clinical assessment room and in a noisy nurse station area. This procedure was repeated on another day, yielding a total of four measurements from each observer (i.e. two room environments and two repeated determinations on 2 separate days) for each Korotkoff sound. The measurement error was then calculated against the reference answer, with the effects of room environment and nursing experience of the observer investigated. Our results showed that there was no statistically significant difference for BPs measured under both quiet and noisy environments (P>0.80 for both SBP and DBP). However, there was a significant effect on the measurement accuracy between the observer groups (P<0.001 for both SBP and DBP). The nursing students performed best with overall SBP and DBP errors of -0.8±2.4 and 0.1±1.8 mmHg, respectively. The SBP measurement error from the nursing students was significantly smaller than that for each of the other three groups (all P<0.001). Our results indicate that frequent nursing trainings are important for nurses to achieve accurate manual auscultatory BP measurement. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29751264','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29751264">Rapid thermal responsive conductive hybrid cryogels with shape memory properties, photothermal properties and pressure dependent conductivity.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Deng, Zexing; Guo, Yi; Ma, Peter X; Guo, Baolin 2018-09-15 Stimuli responsive cryogels with multi-functionality have potential application for electrical devices, actuators, sensors and biomedical devices. However, conventional thermal sensitive poly(N-isopropylacrylamide) cryogels show slow temperature response speed and lack of multi-functionality, which greatly limit their practical application. Herein we present conductive fast (2 min for both deswelling and reswelling behavior) thermally responsive poly(N-isopropylacrylamide) cryogels with rapid shape memory properties (3 s for shape recovery), near-infrared (NIR) light sensitivity and pressure dependent conductivity, and further demonstrated their applications as temperature sensitive on-off switch, NIR light sensitive on-off switch, water triggered shape memory on-off switch and pressure dependent device. These cryogels were first prepared in dimethyl sulfoxide below its melting temperature in ice bath and subsequently put into aniline or pyrrole solution to in situ deposition of conducting polyaniline or polypyrrole nanoparticles. The continuous macroporous sponge-like structure provides cryogels with rapid responsivity both in deswelling, reswelling kinetics and good elasticity. After incorporating electrically conductive polyaniline or polypyrrole nanoaggregates, the hybrid cryogels exhibit desirable conductivity, photothermal property, pressure dependent conductivity and good cytocompatibility. These multifunctional hybrid cryogels make them great potential as stimuli responsive electrical device, tissue engineering scaffolds, drug delivery vehicle and electronic skin. Copyright © 2018 Elsevier Inc. All rights reserved. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23598646','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23598646">Exaggerated blood pressure response during the exercise treadmill test as a risk factor for hypertension.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Lima, S G; Albuquerque, M F P M; Oliveira, J R M; Ayres, C F J; Cunha, J E G; Oliveira, D F; Lemos, R R; Souza, M B R; Barbosa e Silva, O 2013-04-01 Exaggerated blood pressure response (EBPR) during the exercise treadmill test (ETT) has been considered to be a risk factor for hypertension. The relationship of polymorphisms of the renin-angiotensin system gene with hypertension has not been established. Our objective was to evaluate whether EBPR during exercise is a clinical marker for hypertension. The study concerned a historical cohort of normotensive individuals. The exposed individuals were those who presented EBPR. At the end of the observation period (41.7 months = 3.5 years), the development of hypertension was analyzed within the two groups. Genetic polymorphisms and blood pressure behavior were assessed as independent variables, together with the classical risk factors for hypertension. The I/D gene polymorphism of the angiotensin-converting enzyme and M235T of angiotensinogen were ruled out as risk factors for hypertension. EBPR during ETT is not an independent influence on the chances of developing hypertension. No differences were observed between the hypertensive and normotensive individuals regarding gender (P = 0.655), skin color (P = 0.636), family history of hypertension (P = 0.225), diabetes mellitus (P = 0.285), or hypertriglyceridemia (P = 0.734). The risk of developing hypertension increased with increasing body mass index (BMI) and advancing age. The risk factors, which independently influenced the development of hypertension, were age and BMI. EBPR did not constitute an independent risk factor for hypertension and is probably a preclinical phase in the spectrum of normotension and hypertension. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5385376','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5385376">Dissecting Low Atmospheric Pressure Stress: Transcriptome Responses to the Components of Hypobaria in Arabidopsis</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Zhou, Mingqi; Callaham, Jordan B.; Reyes, Matthew; Stasiak, Michael; Riva, Alberto; Zupanska, Agata K.; Dixon, Mike A.; Paul, Anna-Lisa; Ferl, Robert J. 2017-01-01 Controlled hypobaria presents biology with an environment that is never encountered in terrestrial ecology, yet the apparent components of hypobaria are stresses typical of terrestrial ecosystems. High altitude, for example, presents terrestrial hypobaria always with hypoxia as a component stress, since the relative partial pressure of O2 is constant in the atmosphere. Laboratory-controlled hypobaria, however, allows the dissection of pressure effects away from the effects typically associated with altitude, in particular hypoxia, as the partial pressure of O2 can be varied. In this study, whole transcriptomes of plants grown in ambient (97 kPa/pO2 = 21 kPa) atmospheric conditions were compared to those of plants transferred to five different atmospheres of varying pressure and oxygen composition for 24 h: 50 kPa/pO2 = 10 kPa, 25 kPa/pO2 = 5 kPa, 50 kPa/pO2 = 21 kPa, 25 kPa/pO2 = 21 kPa, or 97 kPa/pO2 = 5 kPa. The plants exposed to these environments were 10 day old Arabidopsis seedlings grown vertically on hydrated nutrient plates. In addition, 5 day old plants were also exposed for 24 h to the 50 kPa and ambient environments to evaluate age-dependent responses. The gene expression profiles from roots and shoots showed that the hypobaric response contained more complex gene regulation than simple hypoxia, and that adding back oxygen to normoxic conditions did not completely alleviate gene expression changes in hypobaric responses. PMID:28443120 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28443120','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28443120">Dissecting Low Atmospheric Pressure Stress: Transcriptome Responses to the Components of Hypobaria in Arabidopsis.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Zhou, Mingqi; Callaham, Jordan B; Reyes, Matthew; Stasiak, Michael; Riva, Alberto; Zupanska, Agata K; Dixon, Mike A; Paul, Anna-Lisa; Ferl, Robert J 2017-01-01 Controlled hypobaria presents biology with an environment that is never encountered in terrestrial ecology, yet the apparent components of hypobaria are stresses typical of terrestrial ecosystems. High altitude, for example, presents terrestrial hypobaria always with hypoxia as a component stress, since the relative partial pressure of O 2 is constant in the atmosphere. Laboratory-controlled hypobaria, however, allows the dissection of pressure effects away from the effects typically associated with altitude, in particular hypoxia, as the partial pressure of O 2 can be varied. In this study, whole transcriptomes of plants grown in ambient (97 kPa/pO 2 = 21 kPa) atmospheric conditions were compared to those of plants transferred to five different atmospheres of varying pressure and oxygen composition for 24 h: 50 kPa/pO 2 = 10 kPa, 25 kPa/pO 2 = 5 kPa, 50 kPa/pO 2 = 21 kPa, 25 kPa/pO 2 = 21 kPa, or 97 kPa/pO 2 = 5 kPa. The plants exposed to these environments were 10 day old Arabidopsis seedlings grown vertically on hydrated nutrient plates. In addition, 5 day old plants were also exposed for 24 h to the 50 kPa and ambient environments to evaluate age-dependent responses. The gene expression profiles from roots and shoots showed that the hypobaric response contained more complex gene regulation than simple hypoxia, and that adding back oxygen to normoxic conditions did not completely alleviate gene expression changes in hypobaric responses. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19119263','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19119263">G-protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among African Americans: sex-specificity and interactions.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Bhatnagar, Vibha; O'Connor, Daniel T; Brophy, Victoria H; Schork, Nicholas J; Richard, Erin; Salem, Rany M; Nievergelt, Caroline M; Bakris, George L; Middleton, John P; Norris, Keith C; Wright, Jackson; Hiremath, Leena; Contreras, Gabriel; Appel, Lawrence J; Lipkowitz, Michael S 2009-03-01 African Americans have a disproportionate burden of hypertension and comorbid disease. Pharmacogenetic markers of blood pressure response have yet to be defined clearly. This study explores the association between G-protein-coupled receptor kinase type 4 (GRK4) variants and blood pressure response to metoprolol among African Americans with early hypertensive nephrosclerosis. Participants from the African American Study of Kidney Disease and Hypertension (AASK) trial were genotyped at three GRK4 polymorphisms: R65L, A142V, and A486V. A Cox proportional hazards model, stratified by gender, was used to determine the relationship between GRK4 variants and time to reach a mean arterial pressure (MAP) of 107 mm Hg, adjusted for other predictors of blood pressure response. Potential interactions between the three polymorphisms were explored by analyzing the effects of gene haplotypes and by stratifying the analysis by neighboring sites. The hazard ratio with 95% confidence interval by A142V among men randomized to a usual MAP (102-107 mm Hg) was 1.54 (1.11-2.44; P = 0.0009). The hazard ratio by A142V with R65/L65 or L65/L65 was 2.14 (1.35-3.39; P = 0.001). Haplotype analyses were consistent but inconclusive. There was no association between A142V and blood pressure response among women. Results suggest a sex-specific relationship between GRK4 A142V and blood pressure response among African-American men with early hypertensive nephrosclerosis. Men with a GRK4 A142 were less responsive to metoprolol if they had a GRK4 L65 variant. The effect of GRK4 variants and blood pressure response to metoprolol should be studied in larger clinical trials. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2715837','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2715837">G-Protein-Coupled Receptor Kinase 4 Polymorphisms and Blood Pressure Response to Metoprolol Among African Americans: Sex-Specificity and Interactions</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Bhatnagar, Vibha; O’Connor, Daniel T.; Brophy, Victoria H.; Schork, Nicholas J.; Richard, Erin; Salem, Rany M.; Nievergelt, Caroline M.; Bakris, George L.; Middleton, John P.; Norris, Keith C.; Wright, Jackson; Hiremath, Leena; Contreras, Gabriel; Appel, Lawrence J.; Lipkowitz, Michael S. 2009-01-01 BACKGROUND African Americans have a disproportionate burden of hypertension and comorbid disease. Pharmacogenetic markers of blood pressure response have yet to be defined clearly. This study explores the association between G-protein-coupled receptor kinase type 4 (GRK4) variants and blood pressure response to metoprolol among African Americans with early hypertensive nephrosclerosis. METHODS Participants from the African American Study of Kidney Disease and Hypertension (AASK) trial were genotyped at three GRK4 polymorphisms: R65L, A142V, and A486V. A Cox proportional hazards model, stratified by gender, was used to determine the relationship between GRK4 variants and time to reach a mean arterial pressure (MAP) of 107 mm Hg, adjusted for other predictors of blood pressure response. Potential interactions between the three polymorphisms were explored by analyzing the effects of gene haplotypes and by stratifying the analysis by neighboring sites. RESULTS The hazard ratio with 95% confidence interval by A142V among men randomized to a usual MAP (102–107 mm Hg) was 1.54 (1.11–2.44; P = 0.0009). The hazard ratio by A142V with R65/L65 or L65/L65 was 2.14 (1.35–3.39; P = 0.001). Haplotype analyses were consistent but inconclusive. There was no association between A142V and blood pressure response among women. CONCLUSIONS Results suggest a sex-specific relationship between GRK4 A142V and blood pressure response among African-American men with early hypertensive nephrosclerosis. Men with a GRK4 A142 were less responsive to metoprolol if they had a GRK4 L65 variant. The effect of GRK4 variants and blood pressure response to metoprolol should be studied in larger clinical trials. PMID:19119263 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/11927200','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/11927200">Accuracy of blood pressure measurement and anthropometry among volunteer observers in a large community survey.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Adams, Claire; Burke, Valerie; Beilin, Lawrie J 2002-04-01 The Busselton Survey is a population survey that is held about every three years. In 1994-1995 a re-survey was held of all past participants and 8,502 attended. Financial constraints precluded employing staff for data collection for blood pressure and anthropometry, these therefore were collected by unpaid lay volunteers. Quality control by a health professional was critical to the assessment and maintenance of accuracy in these measurements. For blood pressure three readings were taken simultaneously by a quality control person and the volunteer using a dual stethoscope. Duplicate anthropometric measurements were taken by a criterion anthropometrist and the volunteer. Inter and intra-observer technical errors of measurement (TEM) were calculated. Sixty-two volunteers were trained to take BP measurements; of these, 38 collected data, and 63 were trained in anthropometry; of these, 30 were suitable as measurers. Training was conducted on a group and individual basis by the quality assurance person for the study both in the Perth metropolitan area and rural Busselton. The TEM for SBP was 1.6 mm Hg (SD 1.0 mm Hg) and 1.5 mm Hg (SD 0.8) for DBP. For skin-folds intra-observer TEM ranged from 0.6 mm to 1.0 mm. Between-observer TEM ranged from 2.1 mm to 5.4 mm. For limb and waist circumferences, intra-observer TEM ranged from 0.3 cm to 1.6 cm. Between-observer TEM for circumferences ranged from 0.5 cm to 1.9 cm. Unpaid volunteer measurers can, if carefully trained and supervised, provide acceptable blood pressure data and anthropometry in large population surveys. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2005SPIE.5969..343K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2005SPIE.5969..343K">Spectroscopic detection of the blanch response at the heel of the foot: a possible diagnostic for stage I pressure ulcers</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Kohlenberg, Elicia M.; Zanca, Jeanne; Brienza, David M.; Levasseur, Michelle A.; Sowa, Michael G. 2005-09-01 Pressure ulcers (sores) can occur when there is constant pressure being applied to tissue for extended periods of time. Immobile people are particularly prone to this problem. Ideally, pressure damage is detected at an early stage, pressure relief is applied and the pressure ulcer is averted. One of the hallmarks of pressure damaged skin is an obliterated blanch response due to compromised microcirculation near the surface of the skin. Visible reflectance spectroscopy can noninvasively probe the blood circulation of the upper layers of skin by measuring the electronic transitions arising from hemoglobin, the primary oxygen carrying protein in blood. A spectroscopic test was developed on a mixed population of 30 subjects to determine if the blanch response could be detected in healthy skin with high sensitivity and specificity regardless of the pigmentation of the skin. Our results suggest that a spectroscopic based blanch response test can accurately detect the blanching of healthy tissue and has the potential to be developed into a screening test for early stage I pressure ulcers. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29016474','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29016474">Cardiac Autonomic and Blood Pressure Responses to an Acute Bout of Kettlebell Exercise.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Wong, Alexei; Nordvall, Michael; Walters-Edwards, Michelle; Lastova, Kevin; Francavillo, Gwendolyn; Summerfield, Liane; Sanchez-Gonzalez, Marcos 2017-10-07 Kettlebell (KB) training has become an extremely popular exercise program for improving both muscle strength and aerobic fitness. However, the cardiac autonomic modulation and blood pressure (BP) responses induced by an acute KB exercise session are currently unknown. Understanding the impact of this exercise modality on the post-exercise autonomic modulation and BP would facilitate appropriate exercise prescription in susceptible populations. The present study evaluated the effects of an acute session of KB exercise on heart rate variability (HRV) and BP responses in healthy individuals. Seventeen (M=10, F=7) healthy subjects completed either a KB or non-exercise control trial in randomized order. HRV and BP measurements were collected at baseline, 3, 10 and 30 min after each trial. There were significant increases (P < 0.01) in heart rate, markers of sympathetic activity (nLF) and sympathovagal balance (nLF/nHF) for 30 min after the trial KB trial, while no changes from baseline were observed after the control trial. There were also significant decreases (P < 0.01) in markers of vagal tone (RMMSD, nHF) for 30 min as well as (P < 0.01) systolic BP and diastolic BP at 10 and 30 min after the trial KB trial while no changes from baseline were observed after the control trial. Our findings indicate that KB exercise increases sympathovagal balance for 30 min post-intervention which is concurrent with an important hypotensive effect. Further research is warranted to evaluate the potential clinical application of KB training in populations that might benefit from post-exercise hypotension, such as hypertensives. </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li class="active">13</li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_14" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li class="active">14</li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="261"> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16182114','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16182114">Measures of total stress-induced blood pressure responses are associated with vascular damage.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Nazzaro, Pietro; Seccia, Teresa; Vulpis, Vito; Schirosi, Gabriella; Serio, Gabriella; Battista, Loredana; Pirrelli, Anna 2005-09-01 The role of cardiovascular reactivity to study hypertension, and the assessment methods, are still controversial. We aimed to verify the association of hypertension and vascular damage with several measures of cardiovascular response. We studied 40 patients with normal-high (132 +/- 1/87 +/- 1 mm Hg) blood pressure (Group 1) and 80 untreated hypertensive subjects. Postischemic forearm vascular resistance (mFVR) served to differentiate hypertensive subjects (142 +/- 2/92 +/- 1 mm Hg v 143 +/- 2/94 +/- 2 mm Hg, P = NS) with a lower (Group 2) and higher (Group 3) hemodynamic index of vascular damage (4.8 +/- .05 v 6.3 +/- .09, P < .001). Reactivity was induced by Stroop (5') and cold pressor (90") tests. We measured muscular contraction and skin conductance as indices of emotional arousal, blood pressure, heart rate, forearm blood flow, and vascular resistance. Reactivity measures included: a) change from baseline, b) residualized score, c) cumulative change from baseline and residualized score, and d) total reactivity as area-under-the-curve (AUC), including changes occurring during baseline and recovery phases. The AUC of systolic blood pressure, diastolic blood pressure, and mFVR progressively increased in the groups (P < .001). Corrections of anthropometric and metabolic confounders were introduced in the Pearson equation between mFVR and reactivity measures. The AUC of SBP, DBP, and forearm blood flow and resistance demonstrated the highest (P < .001) correlation. On multiple regression analysis, AUC of SBP (beta = 0.634) and forearm blood flow (beta = -0.337) were predictive (P < .001) of vascular damage. Total blood pressure stress response, as AUC, including baseline and recovery phases, was significantly better associated with hypertension and vascular damage than the other reactivity measures studied. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23472007','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23472007">Physiological responses to low atmospheric pressure stunning and the implications for welfare.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> McKeegan, D E F; Sandercock, D A; Gerritzen, M A 2013-04-01 In low atmospheric pressure stunning (LAPS), poultry are rendered unconscious before slaughter by gradually reducing oxygen tension in the atmosphere to achieve a progressive anoxia. The effects of LAPS are not instantaneous, so there are legitimate welfare concerns around the experience of birds before loss of consciousness. Using self-contained telemetry logging units, high-quality continuous electroencephalogram (EEG) and electrocardiogram (EKG) recordings were obtained from 28 broiler chickens during exposure to LAPS in a commercial poultry processing plant. Application of LAPS was associated with changes in the EEG pattern in the form of increases in total power, decreases in mean frequency, and in particular, increases in slow-wave (delta) activity, indicating a gradual loss of consciousness. Increased delta wave activity was seen within 10 s of LAPS onset and consistently thereafter, peaking at 30 s into LAPS at which point the EEG signal shared characteristics with that of birds in a surgical plane of anesthesia. During LAPS, heart rate consistently decreased, with more pronounced bradycardia and arrhythmia observed after 30 s. No heart rate increases were observed in the period when the birds were potentially conscious. After an initial quiescent period, brief body movements (presumed to be ataxia/loss of posture) were seen on average at 39 s into the LAPS process. Later (after 120 s on average), artifacts related to clonic (wing flapping) and tonic (muscle spasms) convulsions were observed in the EKG recordings. Based on EEG analysis and body movement responses, a conservative estimate of time to loss of consciousness is approximately 40 s. The lack of behavioral responses indicating aversion or escape and absence of heart rate elevation in the conscious period strongly suggest that birds do not find LAPS induction distressing. Collectively, the results suggest that LAPS is a humane approach that has the potential to improve the welfare of poultry at </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22515476','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22515476">Implementation of pressure ulcer prevention best practice recommendations in acute care: an observational study.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Barker, Anna Lucia; Kamar, Jeannette; Tyndall, Tamara Jane; White, Lyn; Hutchinson, Anastasia; Klopfer, Nicole; Weller, Carolina 2013-06-01 Pressure ulcers are a common but preventable problem in hospitals. Implementation of best practice guideline recommendations can prevent ulcers from occurring. This 9-year cohort study reports prevalence data from point prevalence surveys during the observation period, and three practice metrics to assess implementation of best practice guideline recommendations: (i) nurse compliance with use of a validated pressure ulcer risk assessment and intervention checklist; (ii) accuracy of risk assessment scoring in usual-care nurses and experienced injury prevention nurses; and (iii) use of pressure ulcer prevention strategies. The prevalence of hospital-acquired pressure ulcers decreased following implementation of an evidence-based prevention programme from 12·6% (2 years preprogramme implementation) to 2·6% (6 years postprogramme implementation) (P < 0·001). Audits between 2003 and 2011 of 4368 patient medical records identified compliance with pressure ulcer prevention documentation according to best practice guidelines was high (>84%). A sample of 270 patients formed the sample for the study of risk assessment scoring accuracy and use of prevention strategies. It was found usual-care nurses under-estimated patients' risk of pressure ulcer development and under-utilised prevention strategies compared with experienced injury prevention nurses. Despite a significant reduction in prevalence of hospital-acquired pressure ulcers and high documentation compliance, use of prevention strategies could further be improved to achieve better patient outcomes. Barriers to the use of prevention strategies by nurses in the acute hospital setting require further examination. This study provides important insights into the knowledge translation of pressure ulcer prevention best practice guideline recommendations at The Northern Hospital. © 2012 The Authors. International Wound Journal © 2012 John Wiley & Sons Ltd and Medicalhelplines.com Inc. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19890015222','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19890015222">On the dynamic response of pressure transmission lines in the research of helium-charged free piston Stirling engines</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Miller, Eric L.; Dudenhoefer, James E. 1989-01-01 In free piston Stirling engine research the integrity of both amplitude and phase of the dynamic pressure measurements is critical to the characterization of cycle dynamics and thermodynamics. It is therefore necessary to appreciate all possible sources of signal distortion when designing pressure measurement systems for this type of research. The signal distortion inherent to pressure transmission lines is discussed. Based on results from classical analysis, guidelines are formulated to describe the dynamic response properties of a volume-terminated transmission tube for applications involving helium-charged free piston Stirling engines. The scope and limitations of the dynamic response analysis are considered. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23405070','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23405070">Vascular and inflammatory high fat meal responses in young healthy men; a discriminative role of IL-8 observed in a randomized trial.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Esser, Diederik; Oosterink, Els; op 't Roodt, Jos; Henry, Ronald M A; Stehouwer, Coen D A; Müller, Michael; Afman, Lydia A 2013-01-01 High fat meal challenges are known to induce postprandial low-grade inflammation and endothelial dysfunction. This assumption is largely based on studies performed in older populations or in populations with a progressed disease state and an appropriate control meal is often lacking. Young healthy individuals might be more resilient to such challenges. We therefore aimed to characterize the vascular and inflammatory response after a high fat meal in young healthy individuals. In a double-blind randomized cross-over intervention study, we used a comprehensive phenotyping approach to determine the vascular and inflammatory response after consumption of a high fat shake and after an average breakfast shake in 20 young healthy subjects. Both interventions were performed three times. Many features of the vascular postprandial response, such as FMD, arterial stiffness and micro-vascular skin blood flow were not different between shakes. High fat/high energy shake consumption was associated with a more pronounced increase in blood pressure, heart rate, plasma concentrations of IL-8 and PBMCs gene expression of IL-8 and CD54 (ICAM-1), whereas plasma concentrations of sVCAM1 were decreased compared to an average breakfast. Whereas no difference in postprandial response were observed on classical markers of endothelial function, we did observe differences between consumption of a HF/HE and an average breakfast meal on blood pressure and IL-8 in young healthy volunteers. IL-8 might play an important role in dealing with high fat challenges and might be an early marker for endothelial stress, a stage preceding endothelial dysfunction. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24733953','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24733953">Drivers of extinction risk in African mammals: the interplay of distribution state, human pressure, conservation response and species biology.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Di Marco, Moreno; Buchanan, Graeme M; Szantoi, Zoltan; Holmgren, Milena; Grottolo Marasini, Gabriele; Gross, Dorit; Tranquilli, Sandra; Boitani, Luigi; Rondinini, Carlo 2014-01-01 Although conservation intervention has reversed the decline of some species, our success is outweighed by a much larger number of species moving towards extinction. Extinction risk modelling can identify correlates of risk and species not yet recognized to be threatened. Here, we use machine learning models to identify correlates of extinction risk in African terrestrial mammals using a set of variables belonging to four classes: species distribution state, human pressures, conservation response and species biology. We derived information on distribution state and human pressure from satellite-borne imagery. Variables in all four classes were identified as important predictors of extinction risk, and interactions were observed among variables in different classes (e.g. level of protection, human threats, species distribution ranges). Species biology had a key role in mediating the effect of external variables. The model was 90% accurate in classifying extinction risk status of species, but in a few cases the observed and modelled extinction risk mismatched. Species in this condition might suffer from an incorrect classification of extinction risk (hence require reassessment). An increased availability of satellite imagery combined with improved resolution and classification accuracy of the resulting maps will play a progressively greater role in conservation monitoring. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28350576','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28350576">Absence of resting cardiovascular dysfunction in middle-aged endurance-trained athletes with exaggerated exercise blood pressure responses.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Currie, Katharine D; Sless, Ryan T; Notarius, Catherine F; Thomas, Scott G; Goodman, Jack M 2017-08-01 Untrained individuals with exaggerated blood pressure (EBP) responses to graded exercise testing are characterized as having resting dysfunction of the sympathetic and cardiovascular systems. The purpose of this study was to determine the resting cardiovascular state of endurance-trained individuals with EBP through a comparison of normotensive athletes with and without EBP. EBP was defined as a maximal systolic blood pressure (SBP) at least 190 mmHg and at least 210 mmHg for women and men respectively, in response to a graded exercise test. Twenty-two life-long endurance-trained athletes (56 ± 5 years, 16 men) with EBP (EBP+) and 11 age and sex-matched athletes (55 ± 5 years, eight men) without EBP (EBP-) participated in the study. Sympathetic reactivity was assessed using BP responses to a cold pressor test, isometric handgrip exercise, and postexercise muscle ischemia. Resting left ventricular structure and function was assessed using two-dimensional echocardiography, whereas central arterial stiffness was assessed using carotid-to-femoral pulse wave velocity. Calf vascular conductance was measured at rest and peak postexercise using strain-gauge plethysmography. All sympathetic reactivity, left ventricular, and arterial stiffness indices were similar between groups. There was no between-group difference in resting vascular conductance, whereas peak vascular conductance was higher in EBP+ relative to EBP- (1.81 ± 0.65 vs. 1.45 ± 0.32 ml/100 ml/min/mmHg, P < 0.05). Findings from this study suggest that athletes with EBP do not display the resting cardiovascular state typically observed in untrained individuals with EBP. This response in athletes, therefore, is likely a compensatory mechanism to satisfy peripheral blood-flow demands rather than indicative of latent dysfunction. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29582991','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29582991">Capacitive Pressure Sensor with High Sensitivity and Fast Response to Dynamic Interaction Based on Graphene and Porous Nylon Networks.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> He, Zhongfu; Chen, Wenjun; Liang, Binghao; Liu, Changyong; Yang, Leilei; Lu, Dongwei; Mo, Zichao; Zhu, Hai; Tang, Zikang; Gui, Xuchun 2018-04-18 Flexible pressure sensors are of great importance to be applied in artificial intelligence and wearable electronics. However, assembling a simple structure, high-performance capacitive pressure sensor, especially for monitoring the flow of liquids, is still a big challenge. Here, on the basis of a sandwich-like structure, we propose a facile capacitive pressure sensor optimized by a flexible, low-cost nylon netting, showing many merits including a high response sensitivity (0.33 kPa -1 ) in a low-pressure regime (<1 kPa), an ultralow detection limit as 3.3 Pa, excellent working stability after more than 1000 cycles, and synchronous monitoring for human pulses and clicks. More important, this sensor exhibits an ultrafast response speed (<20 ms), which enables its detection for the fast variations of a small applied pressure from the morphological changing processes of a droplet falling onto the sensor. Furthermore, a capacitive pressure sensor array is fabricated for demonstrating the ability to spatial pressure distribution. Our developed pressure sensors show great prospects in practical applications such as health monitoring, flexible tactile devices, and motion detection. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19840038244&hterms=fitness&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3Dfitness','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19840038244&hterms=fitness&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3Dfitness">Physical fitness and cardiovascular response to lower body negative pressure</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Raven, P. B.; Rohm-Young, D.; Blomqvist, C. G. 1984-01-01 Klein et al. (1977) have questioned the concept of endurance training as an appropriate means of preparing for prolonged space flights. Their opinion was mainly based on reports of endurance athletes who had a decreased tolerance to orthostatic or gravitational stress induced by lower body negative pressure (LBNP), upright tilt, or whole body water immersion. The present investigation had the objective to determine if the hemodynamic response to LBNP is different between a high and average fit group of subjects. In addition, the discrete aspect of cardiovascular function which had been altered by chronic training was to be identified. On the basis of the results of experiments conducted with 14 young male volunteers, it is concluded that the reflex response to central hypovolemia is altered by endurance exercise training. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://pubs.er.usgs.gov/publication/70032544','USGSPUBS'); return false;" href="https://pubs.er.usgs.gov/publication/70032544">New insights from well responses to fluctuations in barometric pressure</a> <a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a> Butler, J.J.; Jin, W.; Mohammed, G.A.; Reboulet, E.C. 2011-01-01 Hydrologists have long recognized that changes in barometric pressure can produce changes in water levels in wells. The barometric response function (BRF) has proven to be an effective means to characterize this relationship; we show here how it can also be utilized to glean valuable insights into semi-confined aquifer systems. The form of the BRF indicates the degree of aquifer confinement, while a comparison of BRFs between wells sheds light on hydrostratigraphic continuity. A new approach for estimating hydraulic properties of aquitards from BRFs has been developed and verified. The BRF is not an invariant characteristic of a well; in unconfined or semi-confined aquifers, it can change with conditions in the vadose zone. Field data from a long-term research site demonstrate the hydrostratigraphic insights that can be gained from monitoring water levels and barometric pressure. Such insights should be of value for a wide range of practical applications. ?? 2010 The Author(s). Journal compilation ?? 2010 National Ground Water Association. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/15697908','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/15697908">Lattice vibrations and electronic transitions in the rare-earth metals: praseodymium under pressure.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Olijnyk, Helmut; Grosshans, Walter A; Jephcoat, Andrew P 2004-12-17 Praseodymium was investigated by Raman spectroscopy under pressure. A negative pressure shift of the E(2g) mode is observed in the dhcp phase, which indicates that the initial structural sequence hcp-->Sm-type-->dhcp-->fcc as a whole in the regular lanthanides is associated with a softening of this mode. The pressure response of the phonon modes, observed in the monoclinic and alpha-uranium phases, where 4f bonding becomes important, is characteristic for anisotropic bonding properties. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2004PhRvL..93y5505O','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2004PhRvL..93y5505O">Lattice Vibrations and Electronic Transitions in the Rare-Earth Metals: Praseodymium under Pressure</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Olijnyk, Helmut; Grosshans, Walter A.; Jephcoat, Andrew P. 2004-12-01 Praseodymium was investigated by Raman spectroscopy under pressure. A negative pressure shift of the E2g mode is observed in the dhcp phase, which indicates that the initial structural sequence hcp→Sm-type→dhcp→fcc as a whole in the regular lanthanides is associated with a softening of this mode. The pressure response of the phonon modes, observed in the monoclinic and α-uranium phases, where 4f bonding becomes important, is characteristic for anisotropic bonding properties. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2011AGUFMOS31B..06W','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2011AGUFMOS31B..06W">Oscillation Responses to an Extreme Weather Event from a Deep Moored Observing System</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Wang, Z.; Dimarco, S. F.; Stoessel, M. M.; Zhang, X.; Ingle, S. 2011-12-01 In June 2007 tropical Cyclone Gonu passed directly over an ocean observing system consisting of four, deep autonomous mooring stations along the 3000 m isobath in the northern Arabian Sea. Gonu was the largest cyclone known to have occurred in the Arabian Sea or to strike the Arabian Peninsula. The mooring system was designed by Lighthouse R & D Enterprises, Inc. and installed in cooperation with the Oman Ministry of Agriculture and Fisheries Wealth. The instruments on the moorings continuously recorded water velocities, temperature, conductivity, pressure, dissolved oxygen and turbidity at multiple depths and at hourly intervals during the storm. Near-inertial oscillations at all moorings from thermocline to seafloor are coincident with the arrival of Gonu. Sub-inertial oscillations with periods of 2-10 days are recorded at the post-storm relaxation stage of Gonu, primarily in the thermocline. These oscillations consist of warm, saline water masses, likely originating from the Persian Gulf. Prominent 12.7-day sub-inertial waves, measured at a station ~300 km offshore, are bottom-intensified and have characteristics of baroclinic, topographically-trapped waves. Theoretical results from a topographically-trapped wave model are in a good agreement with the observed 12.7-day waves. The wavelength of the 12.7-day waves is about 590 km calculated from the dispersion relationship. Further analysis suggests that a resonant standing wave is responsible for trapping the 12.7-day wave energy inside the Sea of Oman basin. The observational results reported here are the first measurements of deepwater responses to a tropical cyclone in the Sea of Oman/Arabian Sea. Our study demonstrates the utility of sustained monitoring for studying the impact of extreme weather events on the ocean. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27763873','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27763873">Whole body heat stress attenuates the pressure response to muscle metaboreceptor stimulation in humans.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Cui, Jian; Blaha, Cheryl; Sinoway, Lawrence I 2016-11-01 The effects of whole body heat stress on sympathetic and cardiovascular responses to stimulation of muscle metaboreceptors and mechanoreceptors remains unclear. We examined the muscle sympathetic nerve activity (MSNA), blood pressure, and heart rate in 14 young healthy subjects during fatiguing isometric handgrip exercise, postexercise circulatory occlusion (PECO), and passive muscle stretch during PECO. The protocol was performed under normothermic and whole body heat stress (increase internal temperature ~0.6°C via a heating suit) conditions. Heat stress increased the resting MSNA and heart rate. Heat stress did not alter the mean blood pressure (MAP), heart rate, and MSNA responses (i.e., changes) to fatiguing exercise. During PECO, whole body heat stress accentuated the heart rate response [change (Δ) of 5.8 ± 1.5 to Δ10.0 ± 2.1 beats/min, P = 0.03], did not alter the MSNA response (Δ16.4 ± 2.8 to Δ17.3 ± 3.8 bursts/min, P = 0.74), and lowered the MAP response (Δ20 ± 2 to Δ12 ± 1 mmHg, P < 0.001). Under normothermic conditions, passive stretch during PECO evoked significant increases in MAP and MSNA (both P < 0.001). Of note, heat stress prevented the MAP and MSNA responses to stretch during PECO (both P > 0.05). These data suggest that whole body heat stress attenuates the pressor response due to metaboreceptor stimulation, and the sympathetic nerve response due to mechanoreceptor stimulation. Copyright © 2016 the American Physiological Society. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23037817','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23037817">Poor cognitive outcome in shunt-responsive idiopathic normal pressure hydrocephalus.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Koivisto, Anne M; Alafuzoff, Irina; Savolainen, Sakari; Sutela, Anna; Rummukainen, Jaana; Kurki, Mitja; Jääskeläinen, Juha E; Soininen, Hilkka; Rinne, Jaakko; Leinonen, Ville 2013-01-01 Idiopathic normal pressure hydrocephalus (iNPH) causes cognitive decline that can be alleviated by shunting, but long-term outcome studies are scarce. To elucidate the long-term cognitive condition of shunt-responsive iNPH patients. The follow-up data (Kuopio University Hospital NPH Registry) of 146 patients diagnosed with iNPH by clinical and radiological examination, 24-hour intraventricular pressure monitoring, frontal cortical biopsy, and response to the shunt were analyzed for signs of dementia. The Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition, and specified memory disorder criteria were used. Median follow-up was 4.8 years. At the end of follow-up, 117 (80%) of the 146 iNPH patients had cognitive decline and 67 (46%) had clinical dementia. The most common clinical diagnoses were Alzheimer disease and vascular dementia. In multivariate analysis of the 146 iNPH patients, memory deficit as a first symptom before shunt (odds ratio [OR] 18.3; 95% confidence interval [CI] 1.9-175), male sex (OR 3.29; 95% CI 1.11-9.73), age (OR 1.17 year; 95% CI 1.07-1.28), and follow-up time (OR 1.20 year; 95% CI 1.02-1.40) predicted dementia. Interestingly, 8 (5%) iNPH patients had dementia without any signs of other neurodegenerative diseases in clinical, neuroradiological, or brain biopsy evaluation. These patients initially presented a full triad of symptoms, with gait disturbance being the most frequent initial symptom followed by deterioration in cognition. The novel findings were (a) a significant risk of dementia in iNPH initially responsive to cerebrospinal fluid shunt, (b) cognitive impairment most commonly due to iNPH-related dementia followed by concurrent degenerative brain disease, and (c) a subgroup with dementia related to iNPH without comorbidities. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21677769','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21677769">Under pressure: response urgency modulates striatal and insula activity during decision-making under risk.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Jones, Catherine L; Minati, Ludovico; Harrison, Neil A; Ward, Jamie; Critchley, Hugo D 2011-01-01 When deciding whether to bet in situations that involve potential monetary loss or gain (mixed gambles), a subjective sense of pressure can influence the evaluation of the expected utility associated with each choice option. Here, we explored how gambling decisions, their psychophysiological and neural counterparts are modulated by an induced sense of urgency to respond. Urgency influenced decision times and evoked heart rate responses, interacting with the expected value of each gamble. Using functional MRI, we observed that this interaction was associated with changes in the activity of the striatum, a critical region for both reward and choice selection, and within the insula, a region implicated as the substrate of affective feelings arising from interoceptive signals which influence motivational behavior. Our findings bridge current psychophysiological and neurobiological models of value representation and action-programming, identifying the striatum and insular cortex as the key substrates of decision-making under risk and urgency. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29748781','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29748781">Plantar blood flow response to accumulated pressure stimulus in diabetic people with different peak plantar pressure: a non-randomized clinical trial.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Pu, Fang; Ren, Weiyan; Fu, Hongyuan; Zheng, Xuan; Yang, Min; Jan, Yih-Kuen; Fan, Yubo 2018-05-11 The aim of this study was to investigate the plantar blood flow response to the same accumulated pressure stimulus in diabetic patients with different peak plantar pressure (PPP), which is important for assessing the risk of diabetic foot ulcer. Eleven diabetic subjects with high PPP (PPP ≥ 207 kPa) and 8 diabetic subjects with low PPP (PPP < 207 kPa) were asked to walk naturally on a treadmill so as to induce an accumulated stimulus of 73,000 kPa·s on their first metatarsal head, which was monitored with a sensorized insole. Blood perfusion (BP) in the first metatarsal head was measured before and after walking. Results showed that blood flow after applying the same walking stimulus was significantly decreased in comparison to the basal BP before walking in both high PPP and low PPP groups (p < 0.05), but no significant differences were found between the two groups in terms of BP parameters and its percentage change (p > 0.05). Moreover, BP parameters were not significantly correlated to PPP and the pressure-time integral (PTI) of the subjects' gait (p > 0.05). This indicated that, besides PPP and PTI, the accumulated mechanical stimulus should be taken into consideration when assessing the risk of diabetic patients developing foot ulcers. Graphical abstract Plantar blood flow response to a walking stimulus. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26292192','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26292192">Patient financial responsibility for observation care.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Kangovi, Shreya; Cafardi, Susannah G; Smith, Robyn A; Kulkarni, Raina; Grande, David 2015-11-01 As observation care grows, Medicare beneficiaries are increasingly likely to revisit observation care instead of being readmitted. This trend has potential financial implications for Medicare beneficiaries because observation care-although typically hospital based-is classified as an outpatient service. Beneficiaries who are readmitted pay the inpatient deductible only once per benefit period. In contrast, beneficiaries who have multiple care episodes under observations status are subject to coinsurance at every stay and could accrue higher cumulative costs. We were interested in answering the question: Do Medicare beneficiaries who revisit observation care pay more than they would have had they been readmitted? We used a 20% sample of the Medicare Outpatient Standard Analytic File (2010-2012) to determine the total cumulative financial liability for Medicare beneficiaries who revisit observation care multiple times within a 60-day period. Participants were fee-for-service Medicare beneficiaries who had Part A and Part B coverage for a full calendar year (or until death) during the study period. Our primary measure was beneficiary financial responsibility for facilities fees. On average, beneficiaries with multiple observation stays in a 60-day period had a cumulative financial liability of $947.40 (803.62), which is significantly lower than the $1100 inpatient deductible (P < 0.01). However, 26.6% of these beneficiaries had a cumulative financial liability that exceeded the inpatient deductible. More than a quarter of Medicare beneficiaries with multiple observation stays in a 60-day time period have a higher financial liability than they would have had under Part A benefits. © 2015 Society of Hospital Medicine. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19900037344&hterms=pressure+group&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D60%26Ntt%3Dpressure%2Bgroup','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19900037344&hterms=pressure+group&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D60%26Ntt%3Dpressure%2Bgroup">Effect of hindlimb suspension on cardiovascular responses to sympathomimetics and lower body negative pressure</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Overton, J. Michael; Tipton, Charles M. 1990-01-01 To determine whether hindlimb suspension is associated with the development of cardiovascular deconditioning, male rats were studied before and after undergoing one of three treatment conditions for 9 days: (1) cage control (n = 15, CON), (2) horizontal suspension (n = 15, HOZ), and (3) head-down suspension (n = 18, HDS). Testing included lower body negative pressure administered during chloralose-urethan anesthesia and graded doses of sympathomimetic agents (norepinephrine, phenylephrine, and tyramine) administered to conscious unrestrained animals. Both HDS and HOZ were associated with a small decrease in the hypotensive response to lower body negative pressure. The HOZ group, but not the HDS group, exhibited augmented reflex tachycardia. Furthermore, both HDS and HOZ groups manifested reduced pressor responses to phenylephrine after treatment. These reductions were associated with significantly attenuated increases in mesenteric vascular resistance. However, baroreflex control of heart rate was not altered by the treatment conditions. Collectively, these results indicate that 9 days of HDS in rats does not elicit hemodynamic response patterns generally associated with cardiovascular deconditioning induced by hypogravic conditions. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017EGUGA..1917228M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017EGUGA..1917228M">The storm time ring current dynamics and response to CMEs and CIRs using Van Allen Probes observations and CIMI simulations</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Mouikis, Christopher; Bingham, Samuel; Kistler, Lynn; Spence, Harlan; Gkioulidou, Matina 2017-04-01 The ring current responds differently to the different solar and interplanetary storm drivers such as coronal mass injections, (CME's), and co-rotating interaction regions (CIR's). Using Van Allen Probes observations, we develop an empirical ring current model of the ring current pressure, the pressure anisotropy and the current density development during the storm phases for both types of storm drivers and for all MLTs inside L 6. Delineating the differences in the ring current development between these two drivers will aid our understanding of the ring current dynamics. We find that during the storm main phase most of the ring current pressure in the pre-midnight inner magnetosphere is contributed by particles on open drift paths that cause the development of a strong partial ring current that causes most of the main phase Dst drop. These particles can reach as deep as L 2 and their pressure compares to the local magnetic field pressure as deep as L 3. During the recovery phase, if these particles are not lost at the magnetopause, will become trapped and will contribute to the symmetric ring current. However, the largest difference between the CME and CIR ring current responses during the storm main and early recovery phases is caused by how the 15 - 60 keV O+ responds to these drivers. This empirical model is compared to the results of CIMI simulations of a CMEs and a CIRs where the model input is comprised of the superposed epoch solar wind conditions of the storms that comprise the empirical model. Different inner magnetosphere boundary conditions are tested in order to match the empirical model results. Comparing the model and simulation results improves our understanding of the ring current dynamics as part of the highly coupled inner magnetosphere system. In addition, within the framework of this empirical model, the prediction of the EMIC wave generation linear theory is tested using the observed plasma parameters and comparing with the observations of </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li class="active">14</li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_15" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li class="active">15</li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="281"> <li> <a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=International+AND+Relations&pg=7&id=EJ1036316','ERIC'); return false;" href="https://eric.ed.gov/?q=International+AND+Relations&pg=7&id=EJ1036316">Change of Higher Education in Response to European Pressures: Conceptualization and Operationalization of Europeanization of Higher Education</a> <a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a> Vukasovic, Martina 2013-01-01 This article focuses on change in higher education in response to environmental pressures, more specifically pressures coming from European integration initiatives with respect to higher education, e.g. the Bologna Process. Significant research attention has so far been focused on the supposed impact of European initiatives on higher education… </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/1198188-investigating-influence-anthropogenic-forcing-observed-mean-extreme-sea-level-pressure-trends-over-mediterranean-region','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/1198188-investigating-influence-anthropogenic-forcing-observed-mean-extreme-sea-level-pressure-trends-over-mediterranean-region">Investigating the Influence of Anthropogenic Forcing on Observed Mean and Extreme Sea Level Pressure Trends over the Mediterranean Region</a> <a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a> Barkhordarian, Armineh We investigate whether the observed mean sea level pressure (SLP) trends over the Mediterranean region in the period from 1975 to 2004 are significantly consistent with what 17 models projected as response of SLP to anthropogenic forcing (greenhouse gases and sulphate aerosols, GS). Obtained results indicate that the observed trends in mean SLP cannot be explained by natural (internal) variability. Externally forced changes are detectable in all seasons, except spring. The large-scale component (spatial mean) of the GS signal is detectable in all the 17 models in winter and in 12 of the 17 models in summer. However, the small-scalemore » component (spatial anomalies about the spatial mean) of GS signal is only detectable in winter within 11 of the 17 models. We also show that GS signal has a detectable influence on observed decreasing (increasing) tendency in the frequencies of extremely low (high) SLP days in winter and that these changes cannot be explained by internal climate variability. While the detection of GS forcing is robust in winter and summer, there are striking inconsistencies in autumn, where analysis points to the presence of an external forcing, which is not GS forcing.« less </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1198188-investigating-influence-anthropogenic-forcing-observed-mean-extreme-sea-level-pressure-trends-over-mediterranean-region','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1198188-investigating-influence-anthropogenic-forcing-observed-mean-extreme-sea-level-pressure-trends-over-mediterranean-region">Investigating the Influence of Anthropogenic Forcing on Observed Mean and Extreme Sea Level Pressure Trends over the Mediterranean Region</a> <a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a> Barkhordarian, Armineh 2012-01-01 We investigate whether the observed mean sea level pressure (SLP) trends over the Mediterranean region in the period from 1975 to 2004 are significantly consistent with what 17 models projected as response of SLP to anthropogenic forcing (greenhouse gases and sulphate aerosols, GS). Obtained results indicate that the observed trends in mean SLP cannot be explained by natural (internal) variability. Externally forced changes are detectable in all seasons, except spring. The large-scale component (spatial mean) of the GS signal is detectable in all the 17 models in winter and in 12 of the 17 models in summer. However, the small-scalemore » component (spatial anomalies about the spatial mean) of GS signal is only detectable in winter within 11 of the 17 models. We also show that GS signal has a detectable influence on observed decreasing (increasing) tendency in the frequencies of extremely low (high) SLP days in winter and that these changes cannot be explained by internal climate variability. While the detection of GS forcing is robust in winter and summer, there are striking inconsistencies in autumn, where analysis points to the presence of an external forcing, which is not GS forcing.« less </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25029917','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25029917">Blood pressure and heart rate response to posteriorly directed pressure applied to the cervical spine in young, pain-free individuals: a randomized, repeated-measures, double-blind, placebo-controlled study.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Yung, Emmanuel; Wong, Michael; Williams, Haddie; Mache, Kyle 2014-08-01 Randomized clinical trial. Objectives To compare the blood pressure (BP) and heart rate (HR) response of healthy volunteers to posteriorly directed (anterior-to-posterior [AP]) pressure applied to the cervical spine versus placebo. Manual therapists employ cervical spine AP mobilizations for various cervical-shoulder pain conditions. However, there is a paucity of literature describing the procedure, cardiovascular response, and safety profile. Thirty-nine (25 female) healthy participants (mean ± SD age, 24.7 ± 1.9 years) were randomly assigned to 1 of 2 groups. Group 1 received a placebo, consisting of light touch applied to the right C6 costal process. Group 2 received AP pressure at the same location. Blood pressure and HR were measured prior to, during, and after the application of AP pressure. One-way analysis of variance and paired-difference statistics were used for data analysis. There was no statistically significant difference between groups for mean systolic BP, mean diastolic BP, and mean HR (P >.05) for all time points. Within-group comparisons indicated statistically significant differences between baseline and post-AP pressure HR (-2.8 bpm; 95% confidence interval: -4.6, -1.1) and between baseline and post-AP pressure systolic BP (-2.4 mmHg; 95% confidence interval: -3.7, -1.0) in the AP group, and between baseline and postplacebo systolic BP (-2.6 mmHg; 95% confidence interval: -4.2, -1.0) in the placebo group. No participants reported any adverse reactions or side effects within 24 hours of testing. AP pressure caused a statistically significant physiologic response that resulted in a minor drop in HR (without causing asystole or vasodepression) after the procedure, whereas this cardiovascular change did not occur for those in the placebo group. Within both groups, there was a small but statistically significant reduction in systolic BP following the procedure. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19900051193&hterms=engine+research&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D20%26Ntt%3Dengine%2Bresearch','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19900051193&hterms=engine+research&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D20%26Ntt%3Dengine%2Bresearch">On the dynamic response of pressure transmission lines in the research of helium-charged free piston Stirling engines</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Miller, Eric L.; Dudenhoefer, James E. 1989-01-01 The signal distortion inherent to pressure transmission lines in free-piston Stirling engine research is discussed. Based on results from classical analysis, guidelines are formulated to describe the dynamic response properties of a volume-terminated transmission tube for applications involving the helium-charged free-piston Stirling engines. The underdamped flow regime is described, the primary resonance frequency is derived, and the pressure phase and amplitude distortion are discussed. The scope and limitation of the dynamic response analysis are considered. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29480431','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29480431">Responses of aquatic macrophytes to anthropogenic pressures: comparison between macrophyte metrics and indices.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Camargo, Julio A 2018-02-26 Macrophyte responses to anthropogenic pressures in two rivers of Central Spain were assessed to check if simple metrics can exhibit a greater discriminatory and explanatory power than complex indices at small spatial scales. Field surveys were undertaken during the summer of 2014 (Duraton River) and the spring of 2015 (Tajuña River). Aquatic macrophytes were sampled using a sampling square (45 × 45 cm). In the middle Duraton River, macrophytes responded positively to the presence of a hydropower dam and a small weir, with Myriophyllum spicatum and Potamogeton pectinatus being relatively favored. Index of Macrophytes (IM) was better than Macroscopic Aquatic Vegetation Index (MAVI) and Fluvial Macrophyte Index (FMI) in detecting these responses, showing positive and significant correlations with total coverage, species richness, and species diversity. In the upper Tajuña River, macrophytes responded both negatively and positively to the occurrence of a trout farm effluent and a small weir, with Leptodictyum riparium and Veronica anagallis-aquatica being relatively favored. Although IM, MAVI, and FMI detected both negative and positive responses, correlations of IM with total coverage, species richness, and species diversity were higher. Species evenness was not sensitive enough to detect either positive or negative responses of aquatic macrophytes along the study areas. Overall, traditional and simple metrics (species composition, total coverage, species richness, species diversity) exhibited a greater discriminatory and explanatory power than more recent and complex indices (IM, MAVI, FMI) when assessing responses of aquatic macrophytes to anthropogenic pressures at impacted specific sites. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29489544','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29489544">Pressure Sores and Systemic Inflammatory Response Syndrome: UC Davis Quality Improvement Initiative.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Jairam, Abhishek; Song, Ping; Patel, Nirav B; Wong, Michael S 2018-05-01 The National Pressure Ulcer Advisory Panel estimates pressure sore care to approach $11 billion annually. It is not uncommon for these patients to present to the emergency department (ED) with a chief concern of a pressure sore, while concurrently carrying an undiagnosed infectious process that is the culprit for the acute presentation, rather than the chronic pressure injury. We aim to identify patients who met systemic inflammatory response syndrome (SIRS) criteria at ED presentation who were referred to plastic and reconstructive surgery for pressure sore debridement prior to a complete medical workup. We hypothesize that a restructuring of the ED triaging system would help conserve hospital resources, reduce costs of pressure sore management, and improve patient care and outcomes by first treating primary, underlying pathologies. This is a retrospective chart review of 36 patients who presented to the University of California, Davis Medical Center Emergency Department with a pressure sore and met SIRS criteria, but obtained a plastic surgery consult prior to a full medical workup. We defined SIRS based on standardized criteria: temperature greater than 100.4°F or less than 96.8°F, pulse rate greater than 90 beats/min, respiratory rate greater than 20 breaths/min or PaCO2 less than 32 mm Hg, white blood cell count greater than 12,000, less than 4000, or greater than 10% bands. Fifty percent of patients (18/36) met SIRS criteria at ED presentation for their pressure sores. Of these SIRS patients, 9 (50%) had a diagnosis of urinary tract infection or urosepsis, 6 (33.3%) had sepsis of undefined origin, and 3 (16.7%) had other diagnoses such as osteomyelitis or acute respiratory distress syndrome. Half of patients consulted while in the University of California, Davis Medical Center Emergency Department with pressure sores met SIRS criteria and received a plastic and reconstructive surgery consult prior to a full medical workup. We propose a new algorithm for </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20120013537&hterms=High+Pressure&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3DHigh%2BPressure','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20120013537&hterms=High+Pressure&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3DHigh%2BPressure">A Record-High Ocean Bottom Pressure in the South Pacific Observed by GRACE</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Boening, Carmen; Lee, Tong; Zlotnicki, Victor 2011-01-01 In late 2009 to early 2010, the Gravity Recovery and Climate Experiment (GRACE) satellite pair observed a record increase in ocean bottom pressure (OBP) over a large mid-latitude region of the South East Pacific. Its magnitude is substantially larger than other oceanic events in the Southern Hemisphere found in the entire GRACE data records (2003-2010) on multi-month time scales. The OBP data help to understand the nature of a similar signal in sea surface height (SSH) anomaly observed by altimetry: the SSH increase is mainly due to mass convergence. Analysis of the barotropic vorticity equation using scatterometer data, atmospheric reanalysis product, and GRACE and altimeter an atmospheric reanalysis product observations suggests that the observed OBP/SSH signal was primarily caused by wind stress curl associated with a strong and persistent anticyclone in late 2009 in combination with effects of planetary vorticity gradient, bottom topography, and friction </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/2759082','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/2759082">Blood pressure and plasma catecholamine responses to various challenges during exercise-recovery in man.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Péronnet, F; Massicotte, D; Paquet, J E; Brisson, G; de Champlain, J 1989-01-01 The purpose of this study was to assess the effects of a 2 h cycle exercise (50% VO2max) on heart rate (HR) and blood pressure (BP), and on plasma epinephrine (E) and norepinephrine (NE) concentrations, during the recovery period in seven normotensive subjects. Measurements were made at rest in supine (20 min) and standing (10 min) positions, during isometric exercise (hand-grip, 3 min, 25% maximal voluntary, contraction), in response to a mild psychosocial challenge (Stroop conflicting color word task) and during a 5-min period of light exercise (42 +/- 3% VO2max). Data were compared to measurements taken on another occasion under similar experimental conditions, without a previous exercise bout (control). The results showed HR to be slightly elevated in all conditions following the exercise bout. However, diastolic and systolic BP during the recovery period following exercise were not significantly different from the values observed in the control situation. Plasma NE concentrations in supine position and in response to the various physiological and/or psychosocial challenges were similar in the control situation and during the recovery period following exercise. On the other hand plasma E (nmol.1-1) was about 50% lower at rest (0.11 +/- 0.03 vs 0.23 +/- 0.04) as well as in response to hand-grip (0.21 +/- 0.04 vs 0.41 +/- 0.20) and the Stroop-test (0.21 +/- 0.05 vs 0.41 +/- 0.15) following the exercise bout.(ABSTRACT TRUNCATED AT 250 WORDS) </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25984597','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25984597">In Situ Observations of Thermoreversible Gelation and Phase Separation of Agarose and Methylcellulose Solutions under High Pressure.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Kometani, Noritsugu; Tanabe, Masahiro; Su, Lei; Yang, Kun; Nishinari, Katsuyoshi 2015-06-04 Thermoreversible sol-gel transitions of agarose and methylcellulose (MC) aqueous solutions on isobaric cooling or heating under high pressure up to 400 MPa have been investigated by in situ observations of optical transmittance and falling-ball experiments. For agarose, which undergoes the gelation on cooling, the application of pressure caused a gradual rise in the cloud-point temperature over the whole pressure range examined, which is almost consistent with the pressure dependence of gelling temperature estimated by falling-ball experiments, suggesting that agarose gel is stabilized by compression and that the gelation occurs nearly in parallel with phase separation under ambient and high-pressure conditions. For MC, which undergoes the gelation on heating, the cloud-point temperature showed a slight rise with an initial elevation of pressure up to ∼150 MPa, whereas it showed a marked depression above 200 MPa. In contrast, the gelling temperature of MC, which is nearly identical to the cloud-point temperature at ambient pressure, showed a monotonous rise with increasing pressure up to 350 MPa, which means that MC undergoes phase separation prior to gelation on heating under high pressure above 200 MPa. Similar results were obtained for the melting process of MC gel on cooling. The unique behavior of the sol-gel transition of MC under high pressure has been interpreted in terms of the destruction of hydrophobic hydration by compression. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://pubs.er.usgs.gov/publication/70023277','USGSPUBS'); return false;" href="https://pubs.er.usgs.gov/publication/70023277">Diamond-anvil cell observations of a new methane hydrate phase in the 100-MPa pressure range</a> <a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a> Chou, I.-Ming; Sharma, A.; Burruss, R.C.; Hemley, R.J.; Goncharov, A.F.; Stern, L.A.; Kirby, S.H. 2001-01-01 A new high-pressure phase of methane hydrate has been identified based on its high optical relief, distinct pressure-temperature phase relations, and Raman spectra. In-situ optical observations were made in a hydrothermal diamond-anvil cell at temperatures between -40?? and 60 ??C and at pressures up to 900 MPa. Two new invariant points were located at -8.7 ??C and 99 MPa for the assemblage consisting of the new phase, structure I methane hydrate, ice Ih, and water, and at 35.3 ??C and 137 MPa for the new phase-structure I methane hydrate-water-methane vapor. Existence of the new phase is critical for understanding the phase relations among the hydrates at low to moderate pressures, and may also have important implications for understanding the hydrogen bonding in H2O and the behavior of water in the planetary bodies, such as Europa, of the outer solar system. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22666073-extrasolar-storms-pressure-dependent-changes-light-curve-phase-brown-dwarfs-from-simultaneous-hst-spitzer-observations','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22666073-extrasolar-storms-pressure-dependent-changes-light-curve-phase-brown-dwarfs-from-simultaneous-hst-spitzer-observations">EXTRASOLAR STORMS: PRESSURE-DEPENDENT CHANGES IN LIGHT-CURVE PHASE IN BROWN DWARFS FROM SIMULTANEOUS HST AND SPITZER OBSERVATIONS</a> <a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a> Yang, Hao; Apai, Dániel; Karalidi, Theodora We present Spitzer /Infrared Array Camera Ch1 and Ch2 monitoring of six brown dwarfs during eight different epochs over the course of 20 months. For four brown dwarfs, we also obtained simulataneous Hubble Space Telescope ( HST )/WFC3 G141 grism spectra during two epochs and derived light curves in five narrowband filters. Probing different pressure levels in the atmospheres, the multiwavelength light curves of our six targets all exhibit variations, and the shape of the light curves evolves over the timescale of a rotation period, ranging from 1.4 to 13 hr. We compare the shapes of the light curves andmore » estimate the phase shifts between the light curves observed at different wavelengths by comparing the phase of the primary Fourier components. We use state-of-the-art atmosphere models to determine the flux contribution of different pressure layers to the observed flux in each filter. We find that the light curves that probe higher pressures are similar and in phase, but are offset and often different from the light curves that probe lower pressures. The phase differences between the two groups of light curves suggest that the modulations seen at lower and higher pressures may be introduced by different cloud layers.« less </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27552645','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27552645">Aging, not age-associated inflammation, determines blood pressure and endothelial responses to acute inflammation.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Lane-Cordova, Abbi D; Ranadive, Sushant M; Kappus, Rebecca M; Cook, Marc D; Phillips, Shane A; Woods, Jeffrey A; Wilund, Kenneth R; Baynard, Tracy; Fernhall, Bo 2016-12-01 Aging is characterized by a state of chronic, low-grade inflammation that impairs vascular function. Acute inflammation causes additional decrements in vascular function, but these responses are not uniform in older compared with younger adults. We sought to determine if older adults with low levels of baseline inflammation respond to acute inflammation in a manner similar to younger adults. We hypothesized age-related differences in the vascular responses to acute inflammation, but that older adults with low baseline inflammation would respond similarly to younger adults. Inflammation was induced with an influenza vaccine in 96 participants [older = 67 total, 38 with baseline C-reactive protein (CRP) > 1.5 mg/l and 29 with CRP < 1.5 mg/l; younger = 29]; serum inflammatory markers IL-6 and CRP, blood pressure and flow-mediated dilation (FMD) were measured 24 and 48 h later. Younger adults increased IL-6 and CRP more than the collective older adult group and increased pulse pressure, whereas older adults decreased SBP and reduced pulse pressure. The entire cohort decreased FMD from 11.3 ± 0.8 to 8.3 ± 0.7 to 8.7 ± 0.7% in younger and from 5.8 ± 0.3 to 5.0 ± 0.4 to 4.7 ± 0.4% in older adults, P less than 0.05 for main effect. Older adult groups with differing baseline CRP had the same IL-6, blood pressure, and FMD response to acute inflammation, P less than 0.05 for all interactions, but the low-CRP group increased CRP at 24 and 48 h (from 0.5 ± 0.1 to 1.4 ± 0.2 to 1.7 ± 0.3 mg/l), whereas the high-CRP group did not (from 4.8 ± 0.5 to 5.4 ± 0.5 to 5.4 ± 0.6 mg/l), P less than 0.001 for interaction. Aging, not age-related chronic, low-grade inflammation, determines the vascular responses to acute inflammation. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5390718','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5390718">Authoritarian parenting predicts reduced electrocortical response to observed adolescent offspring rewards</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Speed, Brittany C.; Nelson, Brady; Bress, Jennifer N.; Hajcak, Greg 2017-01-01 Abstract Parenting styles are robust predictors of offspring outcomes, yet little is known about their neural underpinnings. In this study, 44 parent-adolescent dyads (Mage of adolescent = 12.9) completed a laboratory guessing task while EEG was continuously recorded. In the task, each pair member received feedback about their own monetary wins and losses and also observed the monetary wins and losses of the other member of the pair. We examined the association between self-reported parenting style and parents’ electrophysiological responses to watching their adolescent winning and losing money, dubbed the observational Reward Positivity (RewP) and observational feedback negativity (FN), respectively. Self-reported authoritarian parenting predicted reductions in parents’ observational RewP but not FN. This predictive relationship remained after adjusting for sex of both participants, parents’ responsiveness to their own wins, and parental psychopathology. ‘Exploratory analyses found that permissive parenting was associated with a blunting of the adolescents’ response to their parents’ losses’. These findings suggest that parents’ rapid neural responses to their child’s successes may relate to the harsh parenting behaviors associated with authoritarian parenting. PMID:27613780 </li> <li> <a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA555063','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA555063">Noninvasive Subharmonic Pressure Estimation for Monitoring Breast Cancer Response to Neoadjuvant Therapy</a> <a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a> 2011-09-01 predict disease free survival for cervix cancer (34% disease free survival (DFS) if IFP > 19 mmHg, 68% DFS if IFP < 19 mmHg (p = 0.002)) [11]. Thus, the...pressure predicts survival in patients with cervix cancer independent of clinical prognostic factors and tumor oxygen measurements. Cancer Res...Estimation for Monitoring Breast Cancer Response to Neoadjuvant Therapy PRINCIPAL INVESTIGATOR: Flemming Forsberg, Ph.D </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16846145','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16846145">Observation of contrast agent response to chirp insonation with a simultaneous optical-acoustical system.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Sun, Yang; Zhao, Shukui; Dayton, Paul A; Ferrara, Katherine W 2006-06-01 Rayleigh-Plesset analysis, ultra-high speed photography, and single bubble acoustical recordings previously were applied independently to characterize the radial oscillation and resulting echoes from a microbubble in response to an ultrasonic pulse. In addition, high-speed photography has shown that microbubbles are destroyed over a single pulse or pulse train by diffusion and fragmentation. In order to develop a single model to characterize microbubble echoes based on oscillatory and destructive characteristics, an optical-acoustical system was developed to simultaneously record the optical image and backscattered echo from each microbubble. Combined observation provides the opportunity to compare predictions for oscillation and echoes with experimental results and identify discrepancies due to diffusion or fragmentation. Optimization of agents and insonating pulse parameters may be facilitated with this system. The mean correlation of the predicted and experimental radius-time curves and echoes exceeds 0.7 for the parameters studied here. An important application of this new system is to record and analyze microbubble response to a long pulse in which diffusion is shown to occur over the pulse duration. The microbubble response to an increasing or decreasing chirp is evaluated using this new tool. For chirp insonation beginning with the lower center frequency, low-frequency modulation of the oscillation envelope was obvious. However, low-frequency modulation was not observed in the radial oscillation produced by decreasing chirp insonation. Comparison of the echoes from similar sized microbubbles following increasing and decreasing chirp insonation demonstrated that the echoes were not time-reversed replicas. Using a transmission pressure of 620 kPa, the -6 dB echo length was 0.9 and 1.1 micros for increasing and decreasing chirp insonation, respectively (P = 0.02). The mean power in the low-frequency portion of the echoes was 8 (mV)2 and 13 (mV)2 for increasing </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3108983','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3108983">Under Pressure: Response Urgency Modulates Striatal and Insula Activity during Decision-Making under Risk</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Jones, Catherine L.; Minati, Ludovico; Harrison, Neil A.; Ward, Jamie; Critchley, Hugo D. 2011-01-01 When deciding whether to bet in situations that involve potential monetary loss or gain (mixed gambles), a subjective sense of pressure can influence the evaluation of the expected utility associated with each choice option. Here, we explored how gambling decisions, their psychophysiological and neural counterparts are modulated by an induced sense of urgency to respond. Urgency influenced decision times and evoked heart rate responses, interacting with the expected value of each gamble. Using functional MRI, we observed that this interaction was associated with changes in the activity of the striatum, a critical region for both reward and choice selection, and within the insula, a region implicated as the substrate of affective feelings arising from interoceptive signals which influence motivational behavior. Our findings bridge current psychophysiological and neurobiological models of value representation and action-programming, identifying the striatum and insular cortex as the key substrates of decision-making under risk and urgency. PMID:21677769 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3983933','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3983933">Drivers of extinction risk in African mammals: the interplay of distribution state, human pressure, conservation response and species biology</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Di Marco, Moreno; Buchanan, Graeme M.; Szantoi, Zoltan; Holmgren, Milena; Grottolo Marasini, Gabriele; Gross, Dorit; Tranquilli, Sandra; Boitani, Luigi; Rondinini, Carlo 2014-01-01 Although conservation intervention has reversed the decline of some species, our success is outweighed by a much larger number of species moving towards extinction. Extinction risk modelling can identify correlates of risk and species not yet recognized to be threatened. Here, we use machine learning models to identify correlates of extinction risk in African terrestrial mammals using a set of variables belonging to four classes: species distribution state, human pressures, conservation response and species biology. We derived information on distribution state and human pressure from satellite-borne imagery. Variables in all four classes were identified as important predictors of extinction risk, and interactions were observed among variables in different classes (e.g. level of protection, human threats, species distribution ranges). Species biology had a key role in mediating the effect of external variables. The model was 90% accurate in classifying extinction risk status of species, but in a few cases the observed and modelled extinction risk mismatched. Species in this condition might suffer from an incorrect classification of extinction risk (hence require reassessment). An increased availability of satellite imagery combined with improved resolution and classification accuracy of the resulting maps will play a progressively greater role in conservation monitoring. PMID:24733953 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5225474','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5225474">Long-term MODIS observations of cyanobacterial dynamics in Lake Taihu: Responses to nutrient enrichment and meteorological factors</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Shi, Kun; Zhang, Yunlin; Zhou, Yongqiang; Liu, Xiaohan; Zhu, Guangwei; Qin, Boqiang; Gao, Guang 2017-01-01 We developed and validated an empirical model for estimating chlorophyll a concentrations (Chla) in Lake Taihu to generate a long-term Chla and algal bloom area time series from MODIS-Aqua observations for 2003 to 2013. Then, based on the long-term time series data, we quantified the responses of cyanobacterial dynamics to nutrient enrichment and climatic conditions. Chla showed substantial spatial and temporal variability. In addition, the annual mean cyanobacterial surface bloom area exhibited an increasing trend across the entire lake from 2003 to 2013, with the exception of 2006 and 2007. High air temperature and phosphorus levels in the spring can prompt cyanobacterial growth, and low wind speeds and low atmospheric pressure levels favor cyanobacterial surface bloom formation. The sensitivity of cyanobacterial dynamics to climatic conditions was found to vary by region. Our results indicate that temperature is the most important factor controlling Chla inter-annual variability followed by phosphorus and that air pressure is the most important factor controlling cyanobacterial surface bloom formation followed by wind speeds in Lake Taihu. PMID:28074871 </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AGUFMSH13B2485F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AGUFMSH13B2485F">Atmospheric Responses from Radiosonde Observations of the 2017 Total Solar Eclipse</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Fowler, J. 2017-12-01 The Atmospheric Responses from Radiosonde Observations project during the August 21st, 2017 Total Solar Eclipse was to observe the atmospheric response under the shadow of the Moon using both research and operational earth science instruments run primarily by undergraduate students not formally trained in atmospheric science. During the eclipse, approximately 15 teams across the path of totality launched radiosonde balloon platforms in very rapid, serial sonde deployment. Our strategy was to combine a dense ground observation network with multiple radiosonde sites, located within and along the margins of the path of totality. This can demonstrate how dense observation networks leveraged among various programs can "fill the gaps" in data sparse regions allowing research ideas and questions that previously could not be approached with courser resolution data and improving the scientific understanding and prediction of geophysical and hazardous phenomenon. The core scientific objectives are (1) to make high-resolution surface and upper air observations in several sites along the eclipse path (2) to quantitatively study atmospheric responses to the rapid disappearance of the Sun across the United States, and (3) to assess the performance of high-resolution weather forecasting models in simulating the observed response. Such a scientific campaign, especially unique during a total solar eclipse, provides a rare but life-altering opportunity to attract and enable next-generation of observational scientists. It was an ideal "laboratory" for graduate, undergraduate, citizen scientists and k-12 students and staff to learn, explore and research in STEM. </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li class="active">15</li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_16" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li class="active">16</li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="301"> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20050000547&hterms=power+healthy&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Dpower%2Bhealthy','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20050000547&hterms=power+healthy&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Dpower%2Bhealthy">Hemodynamic and hormonal responses to lower body negative pressure in men with varying profiles of strength and aerobic power</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Convertino, V. A.; Mathes, K. L.; Lasley, M. L.; Tomaselli, C. M.; Frey, M. A.; Hoffler, G. W. 1993-01-01 Hemodynamic, cardiac, and hormonal responses to lower-body negative pressure (LBNP) were examined in 24 healthy men to test the hypothesis that responsiveness of reflex control of blood pressure during orthostatic challenge is associated with interactions between strength and aerobic power. Subjects underwent treadmill tests to determine peak oxygen uptake (VO2max) and isokinetic dynamometer tests to determine knee extensor strength. Based on predetermined criteria, subjects were classified into one of four fitness profiles of six subjects each, matched for age, height, and body mass: (a) low strength/average aerobic fitness, (b) low strength/high aerobic fitness, (c) high strength/average aerobic fitness, and (d) high strength/high aerobic fitness. Following 90 min of 0.11 rad (6 degrees) head-down tilt (HDT), each subject underwent graded LBNP to -6.7 kPa or presyncope, with maximal duration 15 min, while hemodynamic, cardiac, and hormonal responses were measured. All groups exhibited typical hemodynamic, hormonal, and fluid shift responses during LBNP, with no intergroup differences between high and low strength characteristics. Subjects with high aerobic power exhibited greater (P < 0.05) stroke volume and lower (P < 0.05) heart rate, vascular peripheral resistance, and mean arterial pressure during rest, HDT, and LBNP. Seven subjects, distributed among the four fitness profiles, became presyncopal. These subjects showed greatest reduction in mean arterial pressure during LBNP, had greater elevations in vasopressin, and lesser increases in heart rate and peripheral resistance. Neither VO2max nor leg strength were associated with fall in arterial pressure or with syncopal episodes. We conclude that interactions between aerobic and strength fitness characteristics do not influence responses to LBNP challenge. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19448207','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19448207">Automatic algorithm for monitoring systolic pressure variation and difference in pulse pressure.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Pestel, Gunther; Fukui, Kimiko; Hartwich, Volker; Schumacher, Peter M; Vogt, Andreas; Hiltebrand, Luzius B; Kurz, Andrea; Fujita, Yoshihisa; Inderbitzin, Daniel; Leibundgut, Daniel 2009-06-01 Difference in pulse pressure (dPP) reliably predicts fluid responsiveness in patients. We have developed a respiratory variation (RV) monitoring device (RV monitor), which continuously records both airway pressure and arterial blood pressure (ABP). We compared the RV monitor measurements with manual dPP measurements. ABP and airway pressure (PAW) from 24 patients were recorded. Data were fed to the RV monitor to calculate dPP and systolic pressure variation in two different ways: (a) considering both ABP and PAW (RV algorithm) and (b) ABP only (RV(slim) algorithm). Additionally, ABP and PAW were recorded intraoperatively in 10-min intervals for later calculation of dPP by manual assessment. Interobserver variability was determined. Manual dPP assessments were used for comparison with automated measurements. To estimate the importance of the PAW signal, RV(slim) measurements were compared with RV measurements. For the 24 patients, 174 measurements (6-10 per patient) were recorded. Six observers assessed dPP manually in the first 8 patients (10-min interval, 53 measurements); no interobserver variability occurred using a computer-assisted method. Bland-Altman analysis showed acceptable bias and limits of agreement of the 2 automated methods compared with the manual method (RV: -0.33% +/- 8.72% and RV(slim): -1.74% +/- 7.97%). The difference between RV measurements and RV(slim) measurements is small (bias -1.05%, limits of agreement 5.67%). Measurements of the automated device are comparable with measurements obtained by human observers, who use a computer-assisted method. The importance of the PAW signal is questionable. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015AGUFMSM41E2538B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015AGUFMSM41E2538B">Ring Current Response to Different Storm Drivers. Van Allen Probes and Cluster Observations.</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Bingham, S.; Mouikis, C.; Kistler, L. M.; Spence, H. E.; Gkioulidou, M.; Claudepierre, S. G.; Farrugia, C. J. 2015-12-01 The ring current responds differently to the different solar and interplanetary storm drivers such as coronal mass injections, (CME's), co-rotating interaction regions (CIR's), high-speed streamers and other structures. The resulting changes in the ring current particle pressure change the global magnetic field, which affects the transport of the radiation belts. In order to determine the field changes during a storm it is necessary to understand the transport, sources and losses of the particles that contribute to the ring current. The source population of the storm time ring current is the night side plasma sheet. However, it is not clear how these convecting particles affect the storm time ring current pressure development. We use Van Allen Probes and Cluster observations together with the Volland-Stern and dipole magnetic field models to determine the contribution in the ring current pressure of the plasma sheet particles convecting from the night side that are on open drift paths, during the storm evolution. We compare storms that are related to different interplanetary drivers, CME and CIR, as observed at different local times. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA297022','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA297022">Cardiopulmonary Responses to Pressure Breathing.</a> <a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a> 1995-05-01 possible improvement in VAIQ relationships, at least in lowV a/Q regions or shunt. This is equivalent to continuous positive airway pressure ( CPAP ) used clinically to augment arterial oxygenation in patients. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25011495','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25011495">Acute increases in intraluminal pressure improve vasodilator responses in aged soleus muscle feed arteries.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Seawright, John W; Luttrell, Meredith J; Woodman, Christopher R 2014-10-01 We tested the hypothesis that exposure to an acute increase in intraluminal pressure, to mimic pressure associated with a bout of exercise, improves nitric oxide (NO)-mediated endothelium-dependent dilation in aged soleus muscle feed arteries (SFA) and that improved endothelial function would persist after a 2 h recovery period. SFA from young (4-month) and old (24-month) Fischer 344 rats were cannulated and pressurized at 90 (P90) or 130 (P130) cmH2O for 60 min. At the end of the treatment period, pressure in the P130 SFA was lowered to 90 cmH2O for examination of endothelium-dependent [flow or acetylcholine (ACh)] and endothelium-independent [sodium nitroprusside (SNP)] vasodilation. To determine the role of NO, vasodilator responses were assessed in the presence of N (ω)-nitro-L-arginine (L-NNA). To determine whether the effects of pressure persisted following a recovery period at normal pressure, SFA were pressurized to 130 cmH2O for 60 min and subsequently lowered to 90 cmH2O for 2 h before assessing function. ACh- and flow-induced dilations were impaired in old SFA. Treatment with increased pressure for 60 min improved ACh- and flow-induced dilations in old SFA. SNP-induced dilation was improved in old and young SFA. The beneficial effect of pressure treatment on ACh- and flow-induced dilation in old SFA was blocked by L-NNA and was not present following a 2 h recovery period. These results indicate that an acute increase in intraluminal pressure improves NO-mediated endothelium-dependent dilation in aged SFA; however, the beneficial effect does not persist after 2 h. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26750541','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26750541">Evaluation of the internal and external responsiveness of the Pressure Ulcer Scale for Healing (PUSH) tool for assessing acute and chronic wounds.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Choi, Edmond P H; Chin, Weng Yee; Wan, Eric Y F; Lam, Cindy L K 2016-05-01 To examine the internal and external responsiveness of the Pressure Ulcer Scale for Healing (PUSH) tool for assessing the healing progress in acute and chronic wounds. It is important to establish the responsiveness of instruments used in conducting wound care assessments to ensure that they are able to capture changes in wound healing accurately over time. Prospective longitudinal observational study. The key study instrument was the PUSH tool. Internal responsiveness was assessed using paired t-testing and effect size statistics. External responsiveness was assessed using multiple linear regression. All new patients with at least one eligible acute or chronic wound, enrolled in the Nurse and Allied Health Clinic-Wound Care programme between 1 December 2012 - 31 March 2013 were included for analysis (N = 541). Overall, the PUSH tool was able to detect statistically significant changes in wound healing between baseline and discharge. The effect size statistics were large. The internal responsiveness of the PUSH tool was confirmed in patients with a variety of different wound types including venous ulcers, pressure ulcers, neuropathic ulcers, burns and scalds, skin tears, surgical wounds and traumatic wounds. After controlling for age, gender and wound type, subjects in the 'wound improved but not healed' group had a smaller change in PUSH scores than those in the 'wound healed' group. Subjects in the 'wound static or worsened' group had the smallest change in PUSH scores. The external responsiveness was confirmed. The internal and external responsiveness of the PUSH tool confirmed that it can be used to track the healing progress of both acute and chronic wounds. © 2016 The Authors. Journal of Advanced Nursing Published by John Wiley & Sons Ltd. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/7254697','DOE-PATENT-XML'); return false;" href="https://www.osti.gov/biblio/7254697">Pressure-sensitive optrode</a> <a target="_blank" href="http://www.osti.gov/doepatents">DOEpatents</a> Hirschfeld, T.B. 1985-04-09 An apparatus and method are disclosed for sensing changes in pressure and for generating optical signals related to changes in pressure. Light from a fiber optic is directed to a movable surface which is coated with a light-responsive material, and which moves relative to the end of the fiber optic in response to changes in pressure. The same fiber optic collects a portion of the reflected or emitted light from the movable surface. Changes in pressure are determined by measuring changes in the amount of light collected. 5 figs. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2576329','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2576329">Aerophagia and Gastroesophageal Reflux Disease in Patients using Continuous Positive Airway Pressure: A Preliminary Observation</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Watson, Nathaniel F.; Mystkowski, Sue K. 2008-01-01 Study Objectives: Aerophagia is a complication of continuous positive airway pressure (CPAP) therapy for sleep disordered breathing (SDB), whereupon air is forced into the stomach and bowel. Associated discomfort can result in CPAP discontinuation. We hypothesize that aerophagia is associated with gastroesophageal reflux disease (GERD) via mechanisms involving GERD related lower esophageal sphincter (LES) compromise. Methods: Twenty-two subjects with aerophagia and 22 controls, matched for age, gender, and body mass index, who were being treated with CPAP for SDB were compared in regard to clinical aspects of GERD, GERD associated habits, SDB severity as measured by polysomnography, and mean CPAP pressure. Results: More subjects with aerophagia had symptoms of GERD (77.3% vs. 36.4%; p < 0.01) and were on GERD related medications (45.5% vs. 18.2%, p < 0.05) than controls. Regarding polysomnography, mean oxygen saturation percentages were lower in the aerophagia group than controls (95.0% vs. 96.5%, p < 0.05). No other differences were observed, including mean CPAP pressures. No one in the aerophagia group (vs. 27.3% of the control group) was a current tobacco user (p < 0.01). There was no difference in caffeine or alcohol use between the 2 groups. Conclusions: These results imply aerophagia is associated with GERD symptoms and GERD related medication use. This finding suggests a relationship between GERD related LES pathophysiology and the development of aerophagia in patients with SDB treated with CPAP. Citation: Watson NF; Mystkowski SK. Aerophagia and gastroesophageal reflux disease in patients using continuous positive airway pressure: a preliminary observation. J Clin Sleep Med 2008;4(5):434–438. PMID:18853700 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3345817','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3345817">Observing and Studying Extreme Low Pressure Events with Altimetry</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Carrère, Loren; Mertz, Françoise; Dorandeu, Joel; Quilfen, Yves; Patoux, Jerome 2009-01-01 The ability of altimetry to detect extreme low pressure events and the relationship between sea level pressure and sea level anomalies during extra-tropical depressions have been investigated. Specific altimeter treatments have been developed for tropical cyclones and applied to obtain a relevant along-track sea surface height (SSH) signal: the case of tropical cyclone Isabel is presented here. The S- and C-band measurements are used because they are less impacted by rain than the Ku-band, and new sea state bias (SSB) and wet troposphere corrections are proposed. More accurate strong altimeter wind speeds are computed thanks to the Young algorithm. Ocean signals not related to atmospheric pressure can be removed with accuracy, even within a Near Real Time context, by removing the maps of sea level anomaly (SLA) provided by SSALTO/Duacs. In the case of Extra-Tropical Depressions, the classical altimeter processing can be used. Ocean signal not related to atmospheric pressure is along-track filtered. The sea level pressure (SLP)-SLA relationship is investigated for the North Atlantic, North Pacific and Indian oceans; three regression models are proposed allowing restoring an altimeter SLP with a mean error of 5 hPa if compared to ECMWF or buoys SLP. The analysis of barotropic simulation outputs points out the regional variability of the SLP/Model Sea Level relationship and the wind effects. PMID:22573955 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27613780','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27613780">Authoritarian parenting predicts reduced electrocortical response to observed adolescent offspring rewards.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Levinson, Amanda R; Speed, Brittany C; Nelson, Brady; Bress, Jennifer N; Hajcak, Greg 2017-03-01 Parenting styles are robust predictors of offspring outcomes, yet little is known about their neural underpinnings. In this study, 44 parent-adolescent dyads (Mage of adolescent = 12.9) completed a laboratory guessing task while EEG was continuously recorded. In the task, each pair member received feedback about their own monetary wins and losses and also observed the monetary wins and losses of the other member of the pair. We examined the association between self-reported parenting style and parents' electrophysiological responses to watching their adolescent winning and losing money, dubbed the observational Reward Positivity (RewP) and observational feedback negativity (FN), respectively. Self-reported authoritarian parenting predicted reductions in parents' observational RewP but not FN. This predictive relationship remained after adjusting for sex of both participants, parents' responsiveness to their own wins, and parental psychopathology. 'Exploratory analyses found that permissive parenting was associated with a blunting of the adolescents' response to their parents' losses'. These findings suggest that parents' rapid neural responses to their child's successes may relate to the harsh parenting behaviors associated with authoritarian parenting. © The Author (2016). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016AGUFM.V43C3163M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016AGUFM.V43C3163M">Reconciling the Observed and Modeled Southern Hemisphere Circulation Response to Volcanic Eruptions</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> McGraw, M. C.; Barnes, E. A.; Deser, C. 2016-12-01 Confusion exists regarding the tropospheric circulation response to volcanic eruptions, with models and observations seeming to disagree on the sign of the response. The forced Southern Hemisphere circulation response to the eruptions of Pinatubo and El Chichon is shown to be a robust positive annular mode, using over 200 ensemble members from 38 climate models. It is demonstrated that the models and observations are not at odds, but rather, internal climate variability is large and can overwhelm the forced response. It is further argued that the state of ENSO can at least partially explain the sign of the observed anomalies, and may account for the perceived discrepancy between model and observational studies. The eruptions of both El Chichon and Pinatubo occurred during El Nino events, and it is demonstrated that the SAM anomalies following volcanic eruptions are weaker during El Nino events compared to La Nina events. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19770041655&hterms=pelvis&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3Dpelvis','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19770041655&hterms=pelvis&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3Dpelvis">Cardiovascular responses of men and women to lower body negative pressure</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Montgomery, L. D.; Kirk, P. J.; Payne, P. A.; Gerber, R. L.; Newton, S. D.; Williams, B. A. 1977-01-01 Changes in blood flow and blood redistribution were measured by impedance plethysmography in the pelvic and leg regions of six male and four female subjects during three 5-min exposures to -20, -40, and -60 mm Hg lower body negative pressure (LBNP). Female subjects demonstrated significantly higher mean heart rate and lower leg blood flow indices than the male subjects during the recumbent control periods. Men had slightly higher mean resting systolic and diastolic blood pressures and higher mean control pelvic blood indices. Women demonstrated significantly less blood pooling in the legs and slightly less in the pelvic region than the men. All of the 18 tests with male subjects at -60 mm Hg were completed without initial signs of syncope, while only two of the tests with women were completed successfully without the subject exhibiting presyncopal conditions. Results indicate that impedance plethysmography can be used to measure segmental cardiovascular responses during LBNP and that females may be less tolerant to -60 mm Hg LBNP than males. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/10516739','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/10516739">Blood pressure and social support observations from Mamre, South Africa, during social and political transition.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Daniels, A; Hoffman, M; Lombard, C; Steyn, K; Levitt, N; Katzenellenbogen, J 1999-10-01 Social support, by moderating cardiovascular reactivity, has been demonstrated to attenuate the effects of stress on blood pressure in American communities. This is the first report to examine the relationship between social support and blood pressure in a South African context, during a period of infrastructure modernisation and political change. A total of 1240 residents (542 men, 698 women) of mixed ethnic origin, older than 14 years and stratified by age and sex, participated in a survey to determine risk factors for hypertension and cardiovascular diseases. Social support was assessed by a questionnaire developed in consultation with the community. It was defined by interactions that may threaten family harmony (score 1) and by networking between relatives, friends, colleagues and neighbours (score 2). Mean blood pressure of the sample was 130/79 mm Hg (s.d. 25/14 mm Hg). Hypertension prevalence was 26.9%. Only 36% of women compared to 57.3% of men (P < 0.0001) were employed. More women (29%) than men (22%) reported threats to family harmony, but social support networks were similarly perceived by both sexes. Systolic and diastolic blood pressure correlated weakly with score 1 (r = 0.096, P < 0.0007) but no association was observed with score 2. Score 1 was not associated with blood pressure by multiple regression analysis, that included confounding by age, sex, BMI, alcohol consumption and smoking status. Neither threats to family harmony nor networking between relatives, friends or neighbours, significantly influences blood pressure in this community. Measures of social support thought to moderate blood pressure may have limited cross-cultural application. Attitudinal changes during socio-political transition may impact on the generalisability of instruments for measurement. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1025161','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1025161">Increased response of diastolic blood pressure to exercise in patients with coronary artery disease: an index of latent ventricular dysfunction?</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Paraskevaidis, I A; Kremastinos, D T; Kassimatis, A S; Karavolias, G K; Kordosis, G D; Kyriakides, Z S; Toutouzas, P K 1993-01-01 OBJECTIVE--To determine whether an abnormal response of diastolic blood pressure during treadmill exercise stress testing correlated with the number of obstructed vessels and with left ventricular systolic function in patients with coronary artery disease. DESIGN--Diastolic blood pressure was measured invasively during exercise stress testing and coronary angiograms and left ventriculograms were obtained at rest in patients with coronary artery disease. The abnormal (> or = 15 mm Hg) diastolic blood pressure response was compared with the number of obstructed coronary arteries and with left ventricular systolic function. SETTING--Two tertiary referral centres. PATIENTS--50 consecutive patients (mean age 57 years) with coronary artery disease. MAIN OUTCOME MEASURES--The increase in diastolic blood pressure during exercise and its correlation with the appearance and disappearance of ST segment deviation, resting left ventricular systolic function, and the number of obstructed coronary arteries. RESULTS--Group 1: 10 (20%) patients (three with one, four with two, and three with three vessel coronary artery disease) (mean (SD) age 54.7 (12) years) had an abnormal diastolic blood pressure response that appeared 1.2 (0.3) min before ST segment deviation and became normal 0.9 (0.3) min after the ST segment returned to normal. Group 2: 40 (80%) patients (12 with one, 16 with two, and 12 with three vessel coronary arteries disease) (aged 56.8 (8.2) years) had a normal diastolic blood pressure response to stress testing. The ejection fraction (46.3 (5)%) and cardiac index (2.6 (0.1) 1/min/m2) in group 1 were less than in group 2 (61.6 (4.2)% and 3.8 (0.3) 1/min/m2 respectively, p < or = 0.001). The end systolic volume was greater in group 1 than in group 2: 38.7 (0.7 ml/m2 v 28.2 (2.1) ml/m2, p < or = 0.001. CONCLUSION--In patients with coronary artery disease an abnormal increase in diastolic blood pressure during exercise stress testing correlated well with left ventricular </li> <li> <a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19950021570','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19950021570">Observed acoustic and aeroelastic spectral responses of a MOD-2 turbine blade to turbulence excitation</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Kelley, N. D.; Mckenna, H. E.; Jacobs, E. W. 1995-01-01 Early results from a recent experiment designed to directly evaluate the aeroacoustic/elastic spectral responses of a MOD-2 turbine blade to turbulence-induced unsteady blade loads are discussed. The experimental procedure consisted of flying a hot-film anemometer from a tethered balloon in the turbine inflow and simultaneously measuring the fluctuating airload and aeroelastic response at two blade span stations (65% and 87% spans) using surface-mounted, subminiature pressure transducers and standard strain gage instrumentation. The radiated acoustic pressure field was measured with a triad of very-low-frequency microphones placed at ground level, 1.5 rotor diameters upwind of the disk. Initial transfer function estimates for acoustic radiation, blade normal forces, flapwise acceleration/displacement, and chord/flapwise moments are presented. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20861505','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20861505">Genome-wide linkage and positional candidate gene study of blood pressure response to dietary potassium intervention: the genetic epidemiology network of salt sensitivity study.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Kelly, Tanika N; Hixson, James E; Rao, Dabeeru C; Mei, Hao; Rice, Treva K; Jaquish, Cashell E; Shimmin, Lawrence C; Schwander, Karen; Chen, Chung-Shuian; Liu, Depei; Chen, Jichun; Bormans, Concetta; Shukla, Pramila; Farhana, Naveed; Stuart, Colin; Whelton, Paul K; He, Jiang; Gu, Dongfeng 2010-12-01 Genetic determinants of blood pressure (BP) response to potassium, or potassium sensitivity, are largely unknown. We conducted a genome-wide linkage scan and positional candidate gene analysis to identify genetic determinants of potassium sensitivity. A total of 1906 Han Chinese participants took part in a 7-day high-sodium diet followed by a 7-day high-sodium plus potassium dietary intervention. BP measurements were obtained at baseline and after each intervention using a random-zero sphygmomanometer. Significant linkage signals (logarithm of odds [LOD] score, >3) for BP responses to potassium were detected at chromosomal regions 3q24-q26.1, 3q28, and 11q22.3-q24.3. Maximum multipoint LOD scores of 3.09 at 3q25.2 and 3.41 at 11q23.3 were observed for absolute diastolic BP (DBP) and mean arterial pressure (MAP) responses, respectively. Linkage peaks of 3.56 at 3q25.1 and 3.01 at 11q23.3 for percent DBP response and 3.22 at 3q25.2, 3.01 at 3q28, and 4.48 at 11q23.3 for percent MAP response also were identified. Angiotensin II receptor, type 1 (AGTR1), single-nucleotide polymorphism rs16860760 in the 3q24-q26.1 region was significantly associated with absolute and percent systolic BP responses to potassium (P=0.0008 and P=0.0006, respectively). Absolute (95% CI) systolic BP responses for genotypes C/C, C/T, and T/T were -3.71 (-4.02 to -3.40), -2.62 (-3.38 to -1.85), and 1.03 (-3.73 to 5.79) mm Hg, respectively, and percent responses (95% CI) were -3.07 (-3.33 to -2.80), -2.07 (-2.74 to -1.41), and 0.90 (-3.20 to 4.99), respectively. Similar trends were observed for DBP and MAP responses. Genetic regions on chromosomes 3 and 11 may harbor important susceptibility loci for potassium sensitivity. Furthermore, the AGTR1 gene was a significant predictor of BP responses to potassium intake. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/publication/?seqNo115=256581','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/publication/?seqNo115=256581">Responsiveness to child feeding cues: an observational scale</a> <a target="_blank" href="https://www.ars.usda.gov/research/publications/find-a-publication/">USDA-ARS?s Scientific Manuscript database</a> Mismatched caregiver responsiveness to child hunger and satiety cues, is thought to contribute to obesity in infancy and beyond. Assessment of this proposition, however, has been limited by a lack of reliable and valid measures. This research evaluated the interrater reliability of a new observation... </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/15811750','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/15811750">Experimental observation of intraocular pressure changes during microkeratome suctioning in laser in situ keratomileusis.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Bissen-Miyajima, Hiroko; Suzuki, Shintaro; Ohashi, Yoshie; Minami, Keiichiro 2005-03-01 To observe changes in intraocular pressure (IOP), the manner in which the eye is suctioned, and the effect of the number of suction ports. Department of Ophthalmology, Tokyo Dental College, Suidobashi Hospital, Tokyo, Japan. Suction rings with single or dual ports were made of transparent acrylic acid resin to facilitate observation with a digital video camera. The IOP and the duration of the IOP increase (time to reach 90% of the maximum IOP) were measured in 6 porcine eyes with an intra-vein pressure-sensor catheter in the vitreous cavity. The IOP changes were recorded using a personal computer. Suctioning with single- and dual-port suction rings was similar. The IOP increases with single- and dual-port suction rings were similar (99.1 mm Hg +/- 6.1 [SD] and 99.0 +/- 6.5 mm Hg, respectively) (P=.987). The duration of the IOP increase was also similar (4.21 +/- 0.24 seconds and 4.12 +/- 0.33 seconds, respectively) (P=.190). The number of ports did not affect suctioning and changes in IOP. This technique is useful in developing the ideal shape and setting of the suction ring. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018GeoRL..45.4991J','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018GeoRL..45.4991J">Arctic Ocean Freshwater Content and Its Decadal Memory of Sea-Level Pressure</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Johnson, Helen L.; Cornish, Sam B.; Kostov, Yavor; Beer, Emma; Lique, Camille 2018-05-01 Arctic freshwater content (FWC) has increased significantly over the last two decades, with potential future implications for the Atlantic meridional overturning circulation downstream. We investigate the relationship between Arctic FWC and atmospheric circulation in the control run of a coupled climate model. Multiple linear lagged regression is used to extract the response of total Arctic FWC to a hypothetical step increase in the principal components of sea-level pressure. The results demonstrate that the FWC adjusts on a decadal timescale, consistent with the idea that wind-driven ocean dynamics and eddies determine the response of Arctic Ocean circulation and properties to a change in surface forcing, as suggested by idealized models and theory. Convolving the response of FWC to a change in sea-level pressure with historical sea-level pressure variations reveals that the recent observed increase in Arctic FWC is related to natural variations in sea-level pressure. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016AGUFMDI41C2638K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016AGUFMDI41C2638K">Melting temperatures of MgO under high pressure determined by micro-texture observation</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Kimura, T.; Ohfuji, H.; Nishi, M.; Irifune, T. 2016-12-01 Periclase (MgO) is the second abundant mineral after bridgmanite in the Earth's lower mantle, and its melting temperature (Tm) under pressure is important to constrain the chemical composition of ultra-deep magma formed near the mantle-core boundary. However, the melting behavior is highly controversial among previous studies: a laser-heated diamond anvil cell (LHDAC) study reported a melting curve with a dTm/dP of 30 K/GPa at zero pressure [1], while several theoretical computations gave substantially higher dTm/dP of 90 100 K/GPa [2,3]. We performed a series of LHDAC experiments for measurements of Tm of MgO under high pressure, using single crystal MgO as the starting material. The melting was detected by using micro-texture observations of the quenched samples. We found that the laser-heated area of the sample quenched from the Tm in previous LHDAC experiments [1] showed randomly aggregated granular crystals, which was not caused by melting, but by plastic deformation of the sample. This suggests that the Tms of their study were substantially underestimated. On the other hand, the sample recovered from the temperature higher by 1500-1700 K than the Tms in previous LHDAC experiments showed a characteristic internal texture comparable to the solidification texture typically shown in metal casting. We determined the Tms based on the observation of this texture up to 32 GPa. Fitting our Tms to the Simon equation yields dTm/dP of 82 K/GPa at zero pressure, which is consistent with those of the theoretical predictions (90 100 K/GPa) [2,3]. Extrapolation of the present melting curve of MgO to the pressure of the CMB (135 GPa) gives a melting temperature of 8900 K. The present steep melting slope offers the eutectic composition close to peridotite (in terms of Mg/Si ratio) throughout the lower mantle conditions. According to the model for sink/float relationship between the solid mantle and the magma [4], a considerable amount of iron (Fe/(Mg+Fe) > 0.24) is expected </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li class="active">16</li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_17" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li class="active">17</li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="321"> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26235814','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26235814">Exaggerated Exercise Blood Pressure Response and Future Cardiovascular Disease.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Tzemos, Nikolaos; Lim, Pitt O; Mackenzie, Isla S; MacDonald, Thomas M 2015-11-01 Exaggerated blood pressure (BP) response to exercise predicts future hypertension. However, there is considerable lack of understanding regarding the mechanism of how this abnormal response is generated, and how it relates to the future establishment of cardiovascular disease. The authors studied 82 healthy male volunteers without cardiovascular risk factors. The participants were categorized into two age-matched groups depending on their exercise systolic BP (ExSBP) rise after 3 minutes of exercise using a submaximal step test: exaggerated ExSBP group (hyper-responders [peak SBP ≥ 180 mm Hg]) and low ExSBP responder group (hypo-responders [peak SBP <180 mm Hg]). Forearm venous occlusion plethysmography and intra-arterial infusions of acetylcholine (ACh), N(G)-monomethyl-L-arginine (L-NMMA), sodium nitroprusside (SNP), and norepinephrine (NE) were used to assess vascular reactivity. Proximal aortic compliance was assessed with ultrasound, and neurohormonal blood sampling was performed at rest and during peak exercise. The hyper-responder group exhibited a significantly lower increase in forearm blood flow (FBF) with ACh compared with the hypo-responder group (ΔFBF 215% [14] vs 332.3% [28], mean [standard error of the mean]; P<.001), as well as decreased proximal aortic compliance. The vasoconstrictive response to L-NMMA was significantly impaired in the hyper-responder group in comparison to the hypo-responder group (ΔFBF -40.2% [1.6] vs -50.2% [2.6]; P<.05). In contrast, the vascular response to SNP and NE were comparable in both groups. Peak exercise plasma angiotensin II levels were significantly higher in the hyper-responder group (31 [1] vs 23 [2] pg/mL, P=.01). An exaggerated BP response to exercise is related to endothelial dysfunction, decreased proximal aortic compliance, and increased exercise-related neurohormonal activation, the constellation of which may explain future cardiovascular disease. © 2015 Wiley Periodicals, Inc. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=food+AND+additives&pg=4&id=EJ983473','ERIC'); return false;" href="https://eric.ed.gov/?q=food+AND+additives&pg=4&id=EJ983473">Combinations of Response-Dependent and Response-Independent Schedule-Correlated Stimulus Presentation in an Observing Procedure</a> <a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a> DeFulio, Anthony; Hackenberg, Timothy D. 2008-01-01 Pigeons pecked a response key on a variable-interval (VI) schedule, in which responses produced food every 40 s, on average. These VI periods, or components, alternated in irregular fashion with extinction components in which food was unavailable. Pecks on a second (observing) key briefly produced exteroceptive stimuli (houselight flashes)… </li> <li> <a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20110022647','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20110022647">Global Magnetospheric Response to an Interplanetary Shock: THEMIS Observations</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Zhang, Hui; Sibeck, David G.; Zong, Q.-G.; McFadden, James P.; Larson, Davin; Glassmeier, K.-H.; Angelopoulos, V. 2011-01-01 We investigate the global response of geospace plasma environment to an interplanetary shock at approx. 0224 UT on May 28, 2008 from multiple THEMIS spacecraft observations in the magnetosheath (THEMIS B and C) and the mid-afternoon (THEMIS A) and dusk magnetosphere (THEMIS D and E). The interaction of the transmitted interplanetary shock with the magnetosphere has global effects. Consequently, it can affect geospace plasma significantly. After interacting with the bow shock, the interplanetary shock transmitted a fast shock and a discontinuity which propagated through the magnetosheath toward the Earth at speeds of 300 km/s and 137 km/s respectively. THEMIS A observations indicate that the plasmaspheric plume changed significantly by the interplanetary shock impact. The plasmaspheric plume density increased rapidly from 10 to 100/ cubic cm in 4 min and the ion distribution changed from isotropic to strongly anisotropic distribution. Electromagnetic ion cyclotron (EMIC) waves observed by THEMIS A are most likely excited by the anisotropic ion distributions caused by the interplanetary shock impact. To our best knowledge, this is the first direct observation of the plasmaspheric plume response to an interplanetary shock's impact. THEMIS A, but not D or E, observed a plasmaspheric plume in the dayside magnetosphere. Multiple spacecraft observations indicate that the dawn-side edge of the plasmaspheric plume was located between THEMIS A and D (or E). </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27878400','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27878400">Multiphoton microscopy observations of 3D elastin and collagen fiber microstructure changes during pressurization in aortic media.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Sugita, Shukei; Matsumoto, Takeo 2017-06-01 Elastin and collagen fibers play important roles in the mechanical properties of aortic media. Because knowledge of local fiber structures is required for detailed analysis of blood vessel wall mechanics, we investigated 3D microstructures of elastin and collagen fibers in thoracic aortas and monitored changes during pressurization. Using multiphoton microscopy, autofluorescence images from elastin and second harmonic generation signals from collagen were acquired in media from rabbit thoracic aortas that were stretched biaxially to restore physiological dimensions. Both elastin and collagen fibers were observed in all longitudinal-circumferential plane images, whereas alternate bright and dark layers were observed along the radial direction and were recognized as elastic laminas (ELs) and smooth muscle-rich layers (SMLs), respectively. Elastin and collagen fibers are mainly oriented in the circumferential direction, and waviness of collagen fibers was significantly higher than that of elastin fibers. Collagen fibers were more undulated in longitudinal than in radial direction, whereas undulation of elastin fibers was equibiaxial. Changes in waviness of collagen fibers during pressurization were then evaluated using 2-dimensional fast Fourier transform in mouse aortas, and indices of waviness of collagen fibers decreased with increases in intraluminal pressure. These indices also showed that collagen fibers in SMLs became straight at lower intraluminal pressures than those in EL, indicating that SMLs stretched more than ELs. These results indicate that deformation of the aorta due to pressurization is complicated because of the heterogeneity of tissue layers and differences in elastic properties of ELs, SMLs, and surrounding collagen and elastin. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20050000668&hterms=cerebral&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3Dcerebral','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20050000668&hterms=cerebral&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3Dcerebral">The cerebral hemodynamics of normotensive hypovolemia during lower-body negative pressure</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Giller, C. A.; Levine, B. D.; Meyer, Y.; Buckey, J. C.; Lane, L. D.; Borchers, D. J. 1992-01-01 Although severe hypovolemia can lead to hypotension and neurological decline, many patients with neurosurgical disorders experience a significant hypovolemia while autonomic compensatory mechanisms maintain a normal blood pressure. To assess the effects of normotensive hypovolemia upon cerebral hemodynamics, transcranial Doppler ultrasound monitoring of 13 healthy volunteers was performed during graded lower-body negative pressure of up to -50 mm Hg, an accepted laboratory model for reproducing the physiological effects of hypovolemia. Middle cerebral artery flow velocity declined by 16% +/- 4% (mean +/- standard error of the mean) and the ratio between transcranial Doppler ultrasound pulsatility and systemic pulsatility rose 22% +/- 8%, suggesting cerebral small-vessel vasoconstriction in response to the sympathetic activation unmasked by lower-body negative pressure. This vasoconstriction may interfere with the autoregulatory response to a sudden fall in blood pressure, and may explain the common observation of neurological deficit during hypovolemia even with a normal blood pressure. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015AGUFM.T13H..03K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015AGUFM.T13H..03K">Simultaneous observations of reaction kinetics, creep behavior, and AE activities during syndeformational antigorite dehydration at high pressures</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Kubo, T.; Iwasato, T.; Higo, Y.; Kato, T.; Kaneshima, S.; Uehara, S.; Koizumi, S.; Imamura, M.; Tange, Y. 2015-12-01 Intermediate-depth earthquakes are seismic activities in Wadati-Benioff zone at depths from 60 km to 300 km, where subducting plates deform plastically rather than brittle failure. Although it has been reported that unstable faulting occurred during antigorite dehydration even at higher pressures than ~2 GPa (e.g., Jung et al., 2009), the recent study by Chernak and Hirth (2011) revealed that the syndefromational antigorite dehydration does not produces stick-slip instabilities but stable fault slip. In the present study, we newly developed an AE monitoring system for high-pressure reaction-deformation processes combined with D-DIA and synchrotron monochromatic X-ray to observe reaction kinetics, creep behaviors, and AE activities simultaneously. We applied this technique to investigate shear instability during syndeformational antigorite dehydration. High-pressure deformation experiments were conducted up to ~8 GPa, ~1050 K, and strain rates of 3.4-9.2 x 10-5 s-1 in compression using a D-DIA type apparatus installed at BL-04B1, SPring-8. 50 keV mono X-ray were used to measure reaction kinetics and stress-strain data. To monitor shear instabilities by detecting AEs, six piezoelectric devices were positioned between first and second stage anvils of MA 6-6 type system. We used three kinds of starting materials of polycrystalline antigorite, fine-grained forsterite polycrystal, and two-phase mixtures of antigorite and San Carlos olivine (10%, 30%, and 50%atg). Clear contrasts were observed in AE activities between forsterite and antigorite samples. AE activities detected within the forsterite polycrystal suggested (semi) brittle behaviors at low pressures during the cold compression stage. Almost no AEs were detected within the antigorite samples during any stages of cold compression, ramping, deformation, and syndeformational dehydration although localized deformation textures were observed in recovered samples. Instead, we detected some AEs outside the sample </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/18064668','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/18064668">Definition of normality of pressure-flow parameters based on observations in asymptomatic men.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Rosario, Derek J; Woo, Henry H; Chapple, Christopher R 2008-01-01 Clinical nomograms for differentiating obstructed from unobstructed voiding and poor detrusor contractility from normal contractility have traditionally been drawn on the basis of symptomatic response to outflow tract surgery or on urodynamic changes in men with LUTS before and after surgery. The aim of this study was to examine pressure-flow parameters in asymptomatic male volunteers before age-related changes in the lower urinary tract had taken place and to assess detrusor contractility and outflow conditions during physiological bladder filling against clinically used pressure-flow nomograms. Thirty-seven healthy male subjects between the ages of 18 and 40 years volunteered to undergo AUM. A total of 66 fill-void cycles in 25 individuals were evaluable. Mean p(det.Qmax) for the group was 53 +/- 3 cmH(2)O with a mean Q(max) of 24 +/- 2 ml sec(-1). URA of 21 cmH(2)O defined the upper border of normality for the outflow condition. Schäfer's OCO showed the most consistent relationship between estimated urethral pressure at minimal flow and true measured urethral closure pressure. From a clinical perspective, the linear nomograms (ICS and Schäfer) are more easily accessible with the ICS BOOI and obstruction index being the simplest to calculate manually. Minimal differences found between these urodynamic nomograms confirm the clinical value of recommending a single method to facilitate future comparisons between studies. An upper limit of normality for the male outflow condition can be defined by an URA of 21 cmH(2)O, AGN of 40 cmH(2)O or OCO of 1. Results above these reference values should be considered abnormal in this age group and where identified in a different age-group should be explained by physiological or pathophysiological events. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1981mtt..vkif.....C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1981mtt..vkif.....C">Blade pressure measurements</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Chivers, J. W. H. Three measurement techniques which enable rotating pressures to be measured during the normal operation of a gas turbine or a component test rig are described. The first technique was developed specifically to provide steady and transient blade surface pressure data to aid both fan flutter research and general fan performance development. This technique involves the insertion of miniature high frequency response pressure transducers into the fan blades of a large civil gas turbine. The other two techniques were developed to measure steady rotating pressures inside and on the surface of engine or rig turbine blades and also rotating pressures in cooling feed systems. These two low frequency response systems are known as the "pressure pineapple' (a name which resulted from the shape of the original prototype) and the rotating scanivalve. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26088064','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26088064">Aggregate blood pressure responses to serial dietary sodium and potassium intervention: defining responses using independent component analysis.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Chen, Gengsheng; de las Fuentes, Lisa; Gu, Chi C; He, Jiang; Gu, Dongfeng; Kelly, Tanika; Hixson, James; Jacquish, Cashell; Rao, D C; Rice, Treva K 2015-06-20 Hypertension is a complex trait that often co-occurs with other conditions such as obesity and is affected by genetic and environmental factors. Aggregate indices such as principal components among these variables and their responses to environmental interventions may represent novel information that is potentially useful for genetic studies. In this study of families participating in the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) Study, blood pressure (BP) responses to dietary sodium interventions are explored. Independent component analysis (ICA) was applied to 20 variables indexing obesity and BP measured at baseline and during low sodium, high sodium and high sodium plus potassium dietary intervention periods. A "heat map" protocol that classifies subjects based on risk for hypertension is used to interpret the extracted components. ICA and heat map suggest four components best describe the data: (1) systolic hypertension, (2) general hypertension, (3) response to sodium intervention and (4) obesity. The largest heritabilities are for the systolic (64%) and general hypertension (56%) components. There is a pattern of higher heritability for the component response to intervention (40-42%) as compared to those for the traditional intervention responses computed as delta scores (24%-40%). In summary, the present study provides intermediate phenotypes that are heritable. Using these derived components may prove useful in gene discovery applications. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4676757','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4676757">Practice guideline: Idiopathic normal pressure hydrocephalus: Response to shunting and predictors of response</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Halperin, John J.; Kurlan, Roger; Schwalb, Jason M.; Cusimano, Michael D.; Gronseth, Gary; Gloss, David 2015-01-01 Objective: We evaluated evidence for utility of shunting in idiopathic normal pressure hydrocephalus (iNPH) and for predictors of shunting effectiveness. Methods: We identified and classified relevant published studies according to 2004 and 2011 American Academy of Neurology methodology. Results: Of 21 articles, we identified 3 Class I articles. Conclusions: Shunting is possibly effective in iNPH (96% chance subjective improvement, 83% chance improvement on timed walk test at 6 months) (3 Class III). Serious adverse event risk was 11% (1 Class III). Predictors of success included elevated Ro (1 Class I, multiple Class II), impaired cerebral blood flow reactivity to acetazolamide (by SPECT) (1 Class I), and positive response to either external lumbar drainage (1 Class III) or repeated lumbar punctures. Age may not be a prognostic factor (1 Class II). Data are insufficient to judge efficacy of radionuclide cisternography or aqueductal flow measurement by MRI. Recommendations: Clinicians may choose to offer shunting for subjective iNPH symptoms and gait (Level C). Because of significant adverse event risk, risks and benefits should be carefully weighed (Level B). Clinicians should inform patients with iNPH with elevated Ro and their families that they have an increased chance of responding to shunting compared with those without such elevation (Level B). Clinicians may counsel patients with iNPH and their families that (1) positive response to external lumbar drainage or to repeated lumbar punctures increases the chance of response to shunting, and (2) increasing age does not decrease the chance of shunting being successful (both Level C). PMID:26644048 </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2008ApPhL..93w1503L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2008ApPhL..93w1503L">Observation of collisionless heating of low energy electrons in low pressure inductively coupled argon plasmas</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Lee, Min-Hyong; Lee, Hyo-Chang; Chung, Chin-Wook 2008-12-01 Collisionless heating of low energy electrons was observed in low pressure argon rf-biased inductively coupled plasmas (ICPs) by measurement of the electron energy distribution function (EEDF). When only capacitive power (bias) was supplied, the EEDF in the discharge was a bi-Maxwellian distribution with two electron groups. It was found that the low energy electrons were heated up significantly even with a little inductive power (<20 W) even when the discharge was in E mode. Due to the low gas pressure and low temperature of low energy electrons (close to the energy of the Ramsauer minimum), the collisional heating of low energy electrons appears to be negligible. Therefore, this effective heating of the low energy electrons showed a direct experimental evidence of the collisionless heating by inductive field. The significant heating of low energy electrons in E mode indicates that collisionless heating in the skin layer is an important electron heating mechanism of low pressure ICP even when the discharge is in E mode. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19930091965','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19930091965">Knocking Combustion Observed in a Spark-Ignition Engine with Simultaneous Direct and Schlieren High-Speed Motion Pictures and Pressure Records</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Osterstrom, Gordon E 1948-01-01 Simultaneous direct and Schlieren photographs at 40,000 frames per second and correlated pressure records were taken of knocking combustion in a special spark-ignition engine to ascertain the intensity of certain end-zone reactions previously noted from Schlieren photography alone. A violent propagated homogeneous autoignition, or a similar phenomenon, previously observed, was again observed. The pressure records show autoignition of varying violence before the passage of a probable detonation wave. Extensive autoignition without occurrence of gas vibrations was seen in one explosion. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4264620','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4264620">Genome-Wide Linkage and Regional Association Study of Blood Pressure Response to the Cold Pressor Test in Han Chinese: The GenSalt Study</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Yang, Xueli; Gu, Dongfeng; He, Jiang; Hixson, James E.; Rao, Dabeeru C.; Lu, Fanghong; Mu, Jianjun; Jaquish, Cashell E.; Chen, Jing; Huang, Jianfeng; Shimmin, Lawrence C.; Rice, Treva K.; Chen, Jichun; Wu, Xigui; Liu, Depei; Kelly, Tanika N. 2014-01-01 Background Blood pressure (BP) response to cold pressor test (CPT) is associated with increased risk of cardiovascular disease. We performed a genome-wide linkage scan and regional association analysis to identify genetic determinants of BP response to CPT. Methods and Results A total of 1,961 Chinese participants completed the CPT. Multipoint quantitative trait linkage analysis was performed, followed by single-marker and gene-based analyses of variants in promising linkage regions (logarithm of odds, LOD ≥ 2). A suggestive linkage signal was identified for systolic BP (SBP) response to CPT at 20p13-20p12.3, with a maximum multipoint LOD score of 2.37. Based on regional association analysis with 1,351 SNPs in the linkage region, we found that marker rs2326373 at 20p13 was significantly associated with mean arterial pressure (MAP) responses to CPT (P = 8.8×10−6) after FDR adjustment for multiple comparisons. A similar trend was also observed for SBP response (P = 0.03) and DBP response (P = 4.6×10−5). Results of gene-based analyses showed that variants in genes MCM8 and SLC23A2 were associated with SBP response to CPT (P = 4.0×10−5 and 2.7×10−4, respectively), and variants in genes MCM8 and STK35 were associated with MAP response to CPT (P = 1.5×10−5 and 5.0×10−5, respectively). Conclusions Within a suggestive linkage region on chromosome 20, we identified a novel variant associated with BP responses to CPT. We also found gene-based associations of MCM8, SLC23A2 and STK35 in this region. Further work is warranted to confirm these findings. Clinical Trial Registration URL: http://www.clinicaltrials.gov; Unique identifier: NCT00721721. PMID:25028485 </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AGUFMSM21A2549H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AGUFMSM21A2549H">Rapid acceleration of outer radiation belt electrons associated with solar wind pressure pulse: Simulation study with Arase and Van Allen Probe observations</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Hayashi, M.; Yoshizumi, M.; Saito, S.; Matsumoto, Y.; Kurita, S.; Teramoto, M.; Hori, T.; Matsuda, S.; Shoji, M.; Machida, S.; Amano, T.; Seki, K.; Higashio, N.; Mitani, T.; Takashima, T.; Kasahara, Y.; Kasaba, Y.; Yagitani, S.; Ishisaka, K.; Tsuchiya, F.; Kumamoto, A.; Matsuoka, A.; Shinohara, I.; Blake, J. B.; Fennell, J. F.; Claudepierre, S. G. 2017-12-01 Relativistic electron fluxes of the outer radiation belt rapidly change in response to solar wind variations. One of the shortest acceleration processes of electrons in the outer radiation belt is wave-particle interactions between drifting electrons and fast-mode waves induced by compression of the dayside magnetopause caused by interplanetary shocks. In order to investigate this process by a solar wind pressure pulse, we perform a code-coupling simulation using the GEMSIS-RB test particle simulation (Saito et al., 2010) and the GEMSIS-GM global MHD magnetosphere simulation (Matsumoto et al., 2010). As a case study, an interplanetary pressure pulse with the enhancement of 5 nPa is used as the up-stream condition. In the magnetosphere, the fast mode waves with the azimuthal electric field ( negative 𝐸𝜙 : |𝐸&;#120601;| 10 mV/m, azimuthal mode number : m ≤ 2) propagates from the dayside to nightside, interacting with electrons. From the simulation results, we derived effective acceleration model and condition : The electrons whose drift velocities vd ≥ (π/2)Vfast are accelerated efficiently. On December 20, 2016, the Arase (ERG) satellite was launched , allowing more accurate multi-point simultaneous observation with other satellites. We will compare our simulation results with observations from Arase and Van Allen Probes, and investigate the acceleration condition of relativistic electrons associated with storm sudden commencement (SSC). </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2004MeScT..15.1185M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2004MeScT..15.1185M">Exhaust pressure pulsation observation from turbocharger instantaneous speed measurement</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Macián, V.; Luján, J. M.; Bermúdez, V.; Guardiola, C. 2004-06-01 In internal combustion engines, instantaneous exhaust pressure measurements are difficult to perform in a production environment. The high temperature of the exhaust manifold and its pulsating character make its application to exhaust gas recirculation control algorithms impossible. In this paper an alternative method for estimating the exhaust pressure pulsation is presented. A numerical model is built which enables the exhaust pressure pulses to be predicted from instantaneous turbocharger speed measurements. Although the model is data based, a theoretical description of the process is also provided. This combined approach makes it possible to export the model for different engine operating points. Also, compressor contribution in the turbocharger speed pulsation is discussed extensively. The compressor contribution is initially neglected, and effects of this simplified approach are analysed. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19900020445','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19900020445">Renal response to seven days of lower body positive pressure in the squirrel monkey</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Churchill, Susanne; Pollock, David M.; Natale, Mary Ellen; Moore-Ede, Martin C. 1987-01-01 As a ground-based model for weightlessness, the response of the chair-trained squirrel monkey to lower body positive pressure (LBPP) was evaluated in a length of study similar to a typical Space Shuttle mission (7 days). Results were compared to time control experiments that included chair-sitting without exposure to LBPP. Chronic exposure to LBPP results in an acute diuretic and natriuretic response independent of changes in plasma aldosterone concentrations and produces a chronic reduction in fluid volume lasting the duration in the stimulus. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3958600','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3958600">Night Blood Pressure Responses to Atenolol and Hydrochlorothiazide in Black and White Patients With Essential Hypertension</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> 2014-01-01 BACKGROUND Night blood pressure (BP) predicts patient outcomes. Variables associated with night BP response to antihypertensive agents have not been fully evaluated in essential hypertension. METHODS We sought to measure night BP responses to hydrochlorothiazide (HCTZ), atenolol (ATEN), and combined therapy using ambulatory blood pressure (ABP) monitoring in 204 black and 281 white essential hypertensive patients. Initial therapy was randomized; HCTZ and ATEN once daily doses were doubled after 3 weeks and continued for 6 more weeks with the alternate medication added for combined therapy arms. ABP was measured at baseline and after completion of each drug. Night, day, and night/day BP ratio responses (treatment − baseline) were compared in race/sex subgroups. RESULTS Baseline night systolic BP and diastolic BP, and night/day ratios were greater in blacks than whites (P < 0.01, all comparisons). Night BP responses to ATEN were absent and night/day ratios increased significantly in blacks (P < 0.05). At the end of combined therapy, women, blacks, and those starting with HCTZ as opposed to ATEN had significantly greater night BP responses (P < 0.01). Variables that significantly associated with ATEN response differed from those that associated with HCTZ response and those that associated with night BP response differed from those that associated with day BP response. CONCLUSIONS In summary, after completion of HCTZ and ATEN therapy, women, blacks, and those who started with HCTZ had greater night BP responses. Reduced night BP response and increased night/day BP ratios occured with ATEN in blacks. Given the prognostic significance of night BP, strategies for optimizing night BP antihypertensive therapy should be considered. CLINICAL TRIAL REGISTRATION Clinicaltrials.gov identifier NCT00246519 PMID:23886594 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20040112653&hterms=Posture+measurement+blood+pressure&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3DPosture%2Bmeasurement%2Bblood%2Bpressure','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20040112653&hterms=Posture+measurement+blood+pressure&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3DPosture%2Bmeasurement%2Bblood%2Bpressure">Cardiovascular response to lower body negative pressure stimulation before, during, and after space flight</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Baisch, F.; Beck, L.; Blomqvist, G.; Wolfram, G.; Drescher, J.; Rome, J. L.; Drummer, C. 2000-01-01 BACKGROUND: It is well known that space travel cause post-flight orthostatic hypotension and it was assumed that autonomic cardiovascular control deteriorates in space. Lower body negative pressure (LBNP) was used to assess autonomic function of the cardiovascular system. METHODS: LBNP tests were performed on six crew-members before and on the first days post-flight in a series of three space missions. Additionally, two of the subjects performed LBNP tests in-flight. LBNP mimics fluid distribution of upright posture in a gravity independent way. It causes an artificial sequestration of blood, reduces preload, and filtrates plasma into the lower part of the body. Fluid distribution was assessed by bioelectrical impedance and anthropometric measurements. RESULTS: Heart rate, blood pressure, and total peripheral resistance increased significantly during LBNP experiments in-flight. The decrease in stroke volume, the increased pooling of blood, and the increased filtration of plasma into the lower limbs during LBNP indicated that a plasma volume reduction and a deficit of the interstitial volume of lower limbs rather than a change in cardiovascular control was responsible for the in-flight response. Post-flight LBNP showed no signs of cardiovascular deterioration. The still more pronounced haemodynamic changes during LBNP reflected the expected behaviour of cardiovascular control faced with less intravascular volume. In-flight, the status of an intra-and extravascular fluid deficit increases sympathetic activity, the release of vasoactive substances and consequently blood pressure. Post-flight, blood pressure decreases significantly below pre-flight values after restoration of volume deficits. CONCLUSION: We conclude that the cardiovascular changes in-flight are a consequence of a fluid deficit rather than a consequence of changes in autonomic signal processing. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24911311','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24911311">Optic nerve head blood flow response to reduced ocular perfusion pressure by alteration of either the blood pressure or intraocular pressure.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Wang, Lin; Cull, Grant A; Fortune, Brad 2015-04-01 To test the hypothesis that blood flow autoregulation in the optic nerve head has less reserve to maintain normal blood flow in the face of blood pressure-induced ocular perfusion pressure decrease than a similar magnitude intraocular pressure-induced ocular perfusion pressure decrease. Twelve normal non-human primates were anesthetized by continuous intravenous infusion of pentobarbital. Optic nerve blood flow was monitored by laser speckle flowgraphy. In the first group of animals (n = 6), the experimental eye intraocular pressure was maintained at 10 mmHg using a saline reservoir connected to the anterior chamber. The blood pressure was gradually reduced by a slow injection of pentobarbital. In the second group (n = 6), the intraocular pressure was slowly increased from 10 mmHg to 50 mmHg by raising the reservoir. In both experimental groups, optic nerve head blood flow was measured continuously. The blood pressure and intraocular pressure were simultaneously recorded in all experiments. The optic nerve head blood flow showed significant difference between the two groups (p = 0.021, repeat measures analysis of variance). It declined significantly more in the blood pressure group compared to the intraocular pressure group when the ocular perfusion pressure was reduced to 35 mmHg (p < 0.045) and below. There was also a significant interaction between blood flow changes and the ocular perfusion pressure treatment (p = 0.004, adjusted Greenhouse & Geisser univariate test), indicating the gradually enlarged blood flow difference between the two groups was due to the ocular perfusion pressure decrease. The results show that optic nerve head blood flow is more susceptible to an ocular perfusion pressure decrease induced by lowering the blood pressure compared with that induced by increasing the intraocular pressure. This blood flow autoregulation capacity vulnerability to low blood pressure may provide experimental evidence related to the </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2007AGUFM.V51E0830M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2007AGUFM.V51E0830M">Pressure-dependent boron isotopic fractionation observed by column chromatography</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Musashi, M.; Oi, T.; Matsuo, M.; Nomura, M. 2007-12-01 Boron isotopic fractionation factor ( S ) between boron taken up in strongly basic anion exchange resin and boron in aqueous solution was determined by breakthrough column chromatography at 5 and 17 MPa at 25°C, using 0.1 mmol/L boric acid solution as feed solution. The S values obtained were 1.018 and 1.012, respectively, which were smaller than the value reported by using the same chromatographic method at atmospheric pressure at 25°C with the boron concentration of 10 mmol/L, but were larger than the values at the same condition with much higher concentration of 100 and 501 mmol/L, indicating that borate-polymerization reducing the isotopic fractionation was negligible. However, calculations based on the theory of isotope distribution between two phases estimated that 21% (5MPa) and 47% (17MPa) of boron taken up in the resin phase was in the three-coordinated B(OH)3-form, instead of in the four-coordinated B(OH)4--form, at high pressures even with the very diluted solution. We discussed this discrepancy by introducing (1) hydration or (2) a partial molar volume difference between isotopic molecules. It was inferred that borate ions were partially dehydrated upon transfer from the solution phase to the resin phase at high pressures, which resulted in smaller S values compared with those at the atmospheric pressure. Alternatively, it was likely that the S value decreased with increasing pressure, because the difference of the partial isotopic molar volumes between 10B(OH)3 and 11B(OH)3 was larger than that between 10B(OH)4- and 11B(OH)4-. If either will be the case, the influence of a pressure upon the isotope effect may not be negligible for boron isotopic exchange equilibrium. This knowledge is crucial for the principle of the boron isotopic pH-metry reconstructing a chemical variation at the paleo-deep oceanic environment where the early life may have been evolved. </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li class="active">17</li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_18" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active">18</li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="341"> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22818124','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22818124">Biventricular structural and functional responses to aortic constriction in a rabbit model of chronic right ventricular pressure overload.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Apitz, Christian; Honjo, Osami; Humpl, Tilman; Li, Jing; Assad, Renato S; Cho, Mi Y; Hong, James; Friedberg, Mark K; Redington, Andrew N 2012-12-01 Chronic right ventricular (RV) pressure overload results in pathologic RV hypertrophy and diminished RV function. Although aortic constriction has been shown to improve systolic function in acute RV failure, its effect on RV responses to chronic pressure overload is unknown. Adjustable vascular banding devices were placed on the main pulmonary artery and descending aorta. In 5 animals (sham group), neither band was inflated. In 9 animals (PAB group), only the pulmonary arterial band was inflated, with adjustments on a weekly basis to generate systemic or suprasystemic RV pressure at 28 days. In 9 animals, both pulmonary arterial and aortic devices were inflated (PAB + AO group), the pulmonary arterial band as for the PAB group and the aortic band adjusted to increase proximal systolic blood pressure by approximately 20 mm Hg. Effects on the functional performance were assessed 5 weeks after surgery by conductance catheters, followed by histologic and molecular assessment. Contractile performance was significantly improved in the PAB + AO group versus the PAB group for both ventricles. Relative to sham-operated animals, both banding groups showed significant differences in myocardial histologic and molecular responses. Relative to the PAB group, the PAB + AO group showed significantly decreased RV cardiomyocyte diameter, decreased RV collagen content, and reduced RV expression of endothelin receptor type B, matrix metalloproteinase 9, and transforming growth factor β genes. Aortic constriction in an experimental model of chronic RV pressure overload not only resulted in improved biventricular systolic function but also improved myocardial remodeling. These data suggest that chronically increased left ventricular afterload leads to a more physiologically hypertrophic response in the pressure-overloaded RV. Copyright © 2012 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23815169','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23815169">Distinct responses to mechanical grinding and hydrostatic pressure in luminescent chromism of tetrathiazolylthiophene.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Nagura, Kazuhiko; Saito, Shohei; Yusa, Hitoshi; Yamawaki, Hiroshi; Fujihisa, Hiroshi; Sato, Hiroyasu; Shimoikeda, Yuichi; Yamaguchi, Shigehiro 2013-07-17 Luminescent mechanochromism has been intensively studied in the past few years. However, the difference in the anisotropic grinding and the isotropic compression is not clearly distinguished in many cases, in spite of the importance of this discrimination for the application of such mechanochromic materials. We now report the distinct luminescent responses of a new organic fluorophore, tetrathiazolylthiophene, to these stresses. The multichromism is achieved over the entire visible region using the single fluorophore. The different mechanisms of a blue shift by grinding crystals and of a red shift under hydrostatic pressure are fully investigated, which includes a high-pressure single-crystal X-ray diffraction analysis. The anisotropic and isotropic modes of mechanical loading suppress and enhance the excimer formation, respectively, in the 3D hydrogen-bond network. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23710718','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23710718">[Efficacy observation on application of negative pressure therapy in the treatment of superficial partial-thickness scald wound in children].</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Shen, Chuan-an; Chai, Jia-ke; Tuo, Xiao-ye; Cai, Jian-hua; Li, Dong-jie; Zhang, Lin; Zhu, Hua; Cai, Jin-dong 2013-02-01 To observe the effect of negative pressure therapy in the treatment of superficial partial-thickness scald in children. Three hundred and seven children with superficial partial-thickness scald hospitalized from August 2009 to May 2012 were divided into negative pressure therapy group (NPT, n = 145) and control group (C, n = 162) according to the random number table. Patients in group NPT were treated with negative pressure from within post injury day (PID) 3 to PID 9 (with -16 kPa pressure), while traditional occlusive dressing method was used in group C. Changes in body temperature, wound healing condition, frequency of dressing change were compared between group NPT and group C. Bacterial culture results of wounds were compared before and after treatment in group NPT. Volume of drained transudate per one percent of wound area was recorded in group NPT on PID 1 to PID 3. Data were processed with t test or chi-square test. The incidence of high fever was significantly lower in group NPT (26.9%, 39/145) than in group C (63.6%, 103/162, χ(2) = 41.419, P < 0.01). On PID 9, complete wound epithelization was observed in 138 patients in group NPT, and in 7 patients there were a few residual wounds which healed after dressing change for 2 days. The wound healing time of patients in group NPT [(9.2 ± 0.6) d] was obviously shorter than that in group C [(10.1 ± 1.6) d, t = 6.895, P < 0.01]. The frequency of dressing change among patients in group NPT [(2.05 ± 0.22) times] was significantly decreased as compared with that in group C [(4.82 ± 0.81) times, t = 39.878, P < 0.01]. Bacteria were found in wound secretion of seventeen patients in group NPT before treatment, while no bacterium was discovered in all patients after treatment. Volumes of drainage fluid in group NPT were proportional to wound areas, which were respectively (9.8 ± 3.2), (6.2 ± 2.1), (4.1 ± 1.6) mL per one percent of wound area on PID 1, 2, and 3. NPT can decrease times of dressing change, and </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4272451','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4272451">Evidence of a Structural Defect in Ice VII and the Side Chain Dependent Response of Small Model Peptides to Increased Pressure</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Scott, J. Nathan; Vanderkooi, Jane M. 2014-01-01 The effect of high pressure on the OH stretch of dilute HOD in D2O was examined using high pressure FTIR. It was found that at pressures directly above the ice VI to ice VII transition, ice VII displays a splitting in the OH absorption indicative of differing hydrogen bonding environments. This result is contrary to published structures of ice VII in which each OH oscillator should experience an identical electronic environment. The anomalous band was found to decrease in absorbance and finally disappear at ~43.0 kbar. In addition, the pressure response of the amide I′ and II′ bands of three small model peptides was examined. Analysis of these bands’ response to increased pressure indicates significant side chain dependence of their structural rearrangement, which may play a role in the composition of full length proteins of barophilic organisms. PMID:21740637 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28536944','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28536944">Fluid responsiveness predicted by transcutaneous partial pressure of oxygen in patients with circulatory failure: a prospective study.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Xu, Jingyuan; Peng, Xiao; Pan, Chun; Cai, Shixia; Zhang, Xiwen; Xue, Ming; Yang, Yi; Qiu, Haibo 2017-12-01 Significant effort has been devoted to defining parameters for predicting fluid responsiveness. Our goal was to study the feasibility of predicting fluid responsiveness by transcutaneous partial pressure of oxygen (PtcO 2 ) in the critically ill patients. This was a single-center prospective study conducted in the intensive care unit of a tertiary care teaching hospital. Shock patients who presented with at least one clinical sign of inadequate tissue perfusion, defined as systolic blood pressure <90 mmHg or a decrease >40 mmHg in previously hypertensive patients or the need for vasopressive drugs; urine output <0.5 ml/kg/h for 2 h; tachycardia; lactate >4 mmol/l, for less than 24 h in the absence of a contraindication for fluids were eligible to participate in the study. PtcO 2 was continuously recorded before and during a passive leg raising (PLR) test, and then before and after a 250 ml rapid saline infusion in 10 min. Fluid responsiveness is defined as a change in the stroke volume ≥10% after 250 ml of volume infusion. Thirty-four patients were included, and 14 responded to volume expansion. In the responders, the mean arterial pressure, central venous pressure, cardiac output, stroke volume and PtcO 2 increased significantly, while the heart rate decreased significantly by both PLR and volume expansion. Changes in the stroke volume induced either by PLR or volume expansion were significantly greater in responders than in non-responders. The correlation between the changes in PtcO 2 and stroke volume induced by volume expansion was significant. Volume expansion induced an increase in the PtcO 2 of 14% and PLR induced an increase in PtcO 2 of 13% predicted fluid responsiveness. This study suggested the changes in PtcO 2 induced by volume expansion and a PLR test predicted fluid responsiveness in critically ill patients. Trial registration NCT02083757. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017JPhCS.950d2002F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017JPhCS.950d2002F">Tolerance of Artemia to static and shock pressure loading</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Fitzmaurice, B. C.; Appleby-Thomas, G. J.; Painter, J. D.; Ono, F.; McMillan, P. F.; Hazael, R.; Meersman, F. 2017-10-01 Hydrostatic and hydrodynamic pressure loading has been applied to unicellular organisms for a number of years due to interest from food technology and extremophile communities. There is also an emerging interest in the response of multicellular organisms to high pressure conditions. Artemia salina is one such organism. Previous experiments have shown a marked difference in the hatching rate of these organisms after exposure to different magnitudes of pressure, with hydrostatic tests showing hatching rates at pressures up to several GPa, compared to dynamic loading that resulted in comparatively low survival rates at lower pressure magnitudes. In order to begin to investigate the origin of this difference, the work presented here has focussed on the response of Artemia salina to (quasi) one-dimensional shock loading. Such experiments were carried out using the plate-impact technique in order to create a planar shock front. Artemia cysts were investigated in this manner along with freshly hatched larvae (nauplii). The nauplii and cysts were observed post-shock using optical microscopy to detect motility or hatching, respectively. Hatching rates of 18% were recorded at pressures reaching 1.5 GPa, as determined with the aid of numerical models. Subjecting Artemia to quasi-one-dimensional shock loading offers a way to more thoroughly explore the shock pressure ranges these organisms can survive. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AGUFMSM21A2557K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AGUFMSM21A2557K">Energy and mass dependence of the contribution to storm-time plasma pressure observed by Arase/MEP-i</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Kasahara, S.; Keika, K.; Yokota, S.; Hoshino, M.; Seki, K.; Nose, M.; Amano, T.; Yoshizumi, M.; Shinohara, I. 2017-12-01 The ring current is mainly controlled by the ion pressure and its spatial gradient. The ion pressure is dominated by ions with energies of a few to a few 100s keV. Oxygen ions of ionospheric origin can be energized in the plasma sheet and/or the inner magnetosphere up to a few tens to a few hundreds of keV. The ionospheric oxygen ions make a significant contribution to the ion pressure during geomagnetically active periods. This paper examines spatial variations and energy-spectral evolution of energetic ( 10 to 200 keV/q) ions during the main phase of a CIR-driven storm on 17 March 2017 (Storm 1) and a CME-driven storm on 27-28 May 2017 (Storm 2). We use ion data from the MEP-i instrument on board the Arase satellite. The instrument measured energetic ions with energies of 5-120 keV/q during Storm 1 and 9-180 keV/q during Storm 2; ion mass/charge was derived from energy and velocity measurements by an electrostatic analyzer and the time-of-flight system, respectively. Below is a brief summary of the MEP-i observations during the two storms. During Storm 1, MEP-i saw high fluxes of >10 keV/q protons and oxygen ions (and possibly other minor ions) at Lm 3.5 around midnight. MEP-i continued to observe high-flux ions until the end of the main phase. Both proton and oxygen ion pressures increased; the O-to-H ratio increased by about an order of magnitude, from 0.02 to 0.2-0.3. The high-flux >10 keV/q ions consisted of clearly different two populations: one dominated by 5-20 keV/q ions, likely originating from pre-existing cold plasma sheet population; and the other with structured dispersion signatures at 30-90 keV/q, likely due to the penetration of ions accelerated in the near-Earth plasma sheet. We found that both populations contributed to the total pressure almost equally. During Storm 2, MEP-i observed proton and oxygen high fluxes in a wide energy range (10-120 keV/q). The pressure increased for both protons and oxygen ions; the O-to-H ratio increased from 0 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/6937878-photosynthesis-growth-response-almond-increased-atmospheric-ozone-partial-pressures','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/6937878-photosynthesis-growth-response-almond-increased-atmospheric-ozone-partial-pressures">Photosynthesis and growth response of almond to increased atmospheric ozone partial pressures</a> <a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a> Retzlaff, W.A.; Williams, L.E.; DeJong, T.M. Uniform nursery stock of five almond cultivars [Prunus dulcis (Mill) D.A. Webb syn. P. amygdalus Batsch, cv. Butte, Carmel, Mission, Nonpareil, and Sonora] propagated on peach (P. domstica L. Batsch.) rootstock were exposed to three different atmospheric ozone (O[sub 3]) partial pressures. The trees were planted in open-top fumigation chambers on 19 Apr. 1989 at the University of California Kearny Agricultural Center located in the San Joaquin Valley of California. Exposures of the trees to three atmospheric O[sub 3] partial pressures lasted from 1 June to 2 Nov. 1989. The mean 12-h [0800-2000 h Pacific Daylight Time (PDT)] O[sub 3]more » partial pressures measured in the open-top chambers during the experimental period were 0.038, 0.060, and 0.112 [mu]Pa Pa[sup [minus]1] O[sub 3] in the charcoal filtered, ambient, and ambient + O[sub 3] treatments, respectively. Leaf net CO[sub 2] assimilation, trunk cross-sectional area growth, and root, trunk, foliage, and total dry weight of Nonpareil were reduced by increased atmospheric O[sub 3] partial pressures. Mission was unaffected by O[sub 3] and Butte, Carmel, and Sonora were intermediate in their responses. Foliage of Nonpareil also abscised prematurely in the ambient and ambient + O[sub 3] treatments. The results indicate that there are almond cultivars that are sensitive to O[sub 3] exposure.« less </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16963674','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16963674">Effect of treatment with nasal continuous positive airway pressure on ventilatory response to hypoxia and hypercapnia in patients with sleep apnea syndrome.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Spicuzza, Lucia; Bernardi, Luciano; Balsamo, Rossella; Ciancio, Nicola; Polosa, Riccardo; Di Maria, Giuseppe 2006-09-01 The increase in peripheral chemoreflex sensitivity in patients with obstructive sleep apnea (OSA) is associated with activation of autonomic nervous system and hemodynamic responses. Nasal CPAP (nCPAP) is an effective treatment for OSA, but little is known on its effect on chemoreflex sensitivity. To assess the effect of nCPAP treatment or placebo (sham nCPAP) on ventilatory control in patients with OSA. Sleep laboratory of Azienda Ospedaliera Garibaldi. Twenty-five patients with moderate-to-severe OSA. Patients were randomly assigned to either therapeutic nCPAP (use of optimal pressure, n = 15) or sham nCPAP (suboptimal pressure of 1 to 2 cm H2O, n = 10) in a double-blind fashion and treated for 1 month. A rebreathing test to assess ventilatory response to normocapnic hypoxia and normoxic hypercapnia was performed at basal condition and after 1 month of treatment. The use of therapeutic nCPAP or sham nCPAP did not affect daytime percentage of arterial oxygen saturation (SaO2%) or end-tidal P(CO2). The normocapnic hypoxic ventilatory response was reduced after 1 month of treatment with nCPAP (the slope was 1.08 +/- 0.02 L/min/SaO2% at basal condition and 0.53 +/- 0.07 L/min/SaO2% after 1 month of treatment, p = 0.008) [mean +/- SD], but not in patients treated with sham nCPAP (slope, 0.83 +/- 0.09 L/min/SaO2% and 0.85 +/- 0.19 L/min/SaO2% at basal condition and after 1 month, respectively). The normoxic hypercapnic ventilatory response remained unchanged after 1 month in both groups. No changes in ventilatory response to either hypoxia or hypercapnia were observed after a single night of nCPAP treatment. The ventilatory response to hypoxia is reduced during regular treatment, but not after short-term treatment, with nCPAP. Readjusted peripheral oxygen chemosensitivity during nCPAP treatment may be a side effect of both reduced sympathetic activity and increased baroreflex activity, or a possible continuous positive airway pressure-related mechanism leading to a </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013PhyA..392.4905L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013PhyA..392.4905L">Assessing complexity of skin blood flow oscillations in response to locally applied heating and pressure in rats: Implications for pressure ulcer risk</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Liao, Fuyuan; O'Brien, William D.; Jan, Yih-Kuen 2013-10-01 The objective of this study was to investigate the effects of local heating on the complexity of skin blood flow oscillations (BFO) under prolonged surface pressure in rats. Eleven Sprague-Dawley rats were studied: 7 rats underwent surface pressure with local heating (△t=10 °C) and 4 rats underwent pressure without heating. A pressure of 700 mmHg was applied to the right trochanter area of rats for 3 h. Skin blood flow was measured using laser Doppler flowmetry. The loading period was divided into nonoverlapping 30 min epochs. For each epoch, multifractal detrended fluctuation analysis (MDFA) was utilized to compute DFA coefficients and complexity of endothelial related metabolic, neurogenic, and myogenic frequencies of BFO. The results showed that under surface pressure, local heating led to a significant decrease in DFA coefficients of myogenic frequency during the initial epoch of loading period, a sustained decrease in complexity of myogenic frequency, and a significantly higher degree of complexity of metabolic frequency during the later phase of loading period. Surrogate tests showed that the reduction in complexity of myogenic frequency was associated with a loss of nonlinearity whereas increased complexity of metabolic frequency was associated with enhanced nonlinearity. Our results indicate that increased metabolic activity and decreased myogenic response due to local heating manifest themselves not only in magnitudes of metabolic and myogenic frequencies but also in their structural complexity. This study demonstrates the feasibility of using complexity analysis of BFO to monitor the ischemic status of weight-bearing skin and risk of pressure ulcers. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://pubs.er.usgs.gov/publication/70024035','USGSPUBS'); return false;" href="https://pubs.er.usgs.gov/publication/70024035">Experimental observations of pressure oscillations and flow regimes in an analogue volcanic system</a> <a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a> Lane, S.J.; Chouet, B.A.; Phillips, J.C.; Dawson, P.; Ryan, G.A.; Hurst, E. 2001-01-01 Gas-liquid flows, designed to be analogous to those in volcanic conduits, are generated in the laboratory using organic gas-gum rosin mixtures expanding in a vertically mounted tube. The expanding fluid shows a range of both flow and pressure oscillation behaviors. Weakly supersaturated source liquids produce a low Reynolds number flow with foam expanding from the top surface of a liquid that exhibits zero fluid velocity at the tube wall; i.e., the conventional "no-slip" boundary condition. Pressure oscillations, often with strong long-period characteristics and consistent with longitudinal and radial resonant oscillation modes, are detected in these fluids. Strongly supersaturated source liquids generate more energetic flows that display a number of flow regimes. These regimes include a static liquid source, viscous flow, detached flow (comprising gas-pockets-at-wall and foam-in-gas annular flow, therefore demonstrating strong radial heterogeneity), and a fully turbulent transonic fragmented or mist flow. Each of these flow regimes displays characteristic pressure oscillations that can be related to resonance of flow features or wall impact phenomena. The pressure oscillations are produced by the degassing processes without the need of elastic coupling to the confining medium or flow restrictors and valvelike features. The oscillatory behavior of the experimental flows is compared to seismoacoustic data from a range of volcanoes where resonant oscillation of the fluid within the conduit is also often invoked as controlling the observed oscillation frequencies. On the basis of the experimental data we postulate on the nature of seismic signals that may be measured during large-scale explosive activity. Copyright 2001 by the American Geophysical Union. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/3795108','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/3795108">Rapid resetting of rabbit aortic baroreceptors and reflex heart rate responses by directional changes in blood pressure.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Burke, S L; Dorward, P K; Korner, P I 1986-09-01 In both anaesthetized and conscious rabbits, perivascular balloon inflations slowly raised or lowered mean arterial pressure (M.A.P.), at 1-2 mmHg/s, from resting to various plateau pressures. Deflations then returned the M.A.P. to resting. 'Steady-state' curves relating M.A.P. to unitary aortic baroreceptor firing, integrated aortic nerve activity and heart rate were derived during the primary and return pressure changes and they formed typical hysteresis loops. In single units, return M.A.P.-frequency curves were shifted in the same direction as the primary pressure changes by an average 0.37 mmHg per mmHg change in M.A.P. Shifts were linearly related to the changes in M.A.P. between resting and plateau levels for all pressure rises and for falls less than 30 mmHg. They were established within 30 s and were quantitatively similar to the rapid resetting of baroreceptor function curves found 15 min-2 h after a change in resting M.A.P. (Dorward, Andresen, Burke, Oliver & Korner, 1982). Unit threshold pressures were shifted within 20 s to the same extent as the over-all curve shift to which they contributed. In the whole aortic nerve, return M.A.P.-integrated activity curves were shifted to same degree as unit function curves in both anaesthetized and conscious rabbits. Simultaneous shifts of return reflex M.A.P.-heart rate curves were also seen in conscious rabbits within 30 s. During M.A.P. falls, receptor and reflex hysteresis was similar, but during M.A.P. rises, reflex shifts were double baroreceptor shifts, suggesting the involvement of other pressure-sensitive receptors. We conclude that hysteresis shifts in baroreceptor function curves, which follow the reversal of slow ramp changes in blood pressure are a form of rapid resetting. They are accompanied by rapid resetting of reflex heart rate responses. We regard this as an important mechanism in blood pressure control which produces relatively high-gain reflex responses, during slow directional pressure </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25286883','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25286883">Responses of blood pressure and lactate levels to various aquatic exercise movements in postmenopausal women.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Chien, K-Y; Chen, W-C; Kan, N-W; Hsu, M-C; Lee, S-L 2015-12-01 Middle-aged and elderly women represent the main attending group in head-out aquatic exercise (HOAE). Blood pressure (BP) significantly increases both during water immersion and aquatic walking. Based on risk concerns, it is important to evaluate BP responses in postmenopausal women doing HOAE. The aim of this study was to determine BP, lactate levels, and rating of perceived exertion (RPE) changes associated with performing 3 different movements at 3 levels of exercise intensity in water. Twelve postmenopausal women (59.9±0.6 years old) participated in 3 aquatic trials involving running (RU), rocking (RO), and scissor kicks (SK) on separate days. Systolic BP, mean arterial pressure (MAP), lactate levels, RPE, and motion cadence were measured at rest; upon reaching 50%, 65%, and 80% of heart rate reserve for 6 minutes; and 10 and 30 minutes after exercise. Under similar RPE responses at 3 levels of intensity, SK resulted in higher systolic BP, MAP, and lactate levels than RO at 10 minutes after exercise (P<0.05) and the lowest motion cadence (P<0.05). RO resulted in the lowest MAP and diastolic BP responses during exercise (P<0.05). RU resulted in lower responses of lactate levels at high exercise intensity (P<0.05). RO resulted in lower diastolic BP and MAP responses compared with RU and SK during exercise. These findings suggest that RO movement in aquatic exercises is more suitable for people at high risk for cardiovascular disease. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27073301','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27073301">Effects of low and standard intra-abdominal pressure on systemic inflammation and immune response in laparoscopic adrenalectomy: A prospective randomised study.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Schietroma, Mario; Pessia, Beatrice; Stifini, Derna; Lancione, Laura; Carlei, Francesco; Cecilia, Emanuela Marina; Amicucci, Gianfranco 2016-01-01 The advantages of laparoscopic adrenalectomy (LA) over open adrenalectomy are undeniable. Nevertheless, carbon dioxide (CO2) pneumoperitoneum may have an unfavourable effect on the local immune response. The aim of this study was to compare changes in the systemic inflammation and immune response in the early post-operative (p.o.) period after LA performed with standard and low-pressure CO2 pneumoperitoneum. We studied, in a prospective randomised study, 51 patients consecutively with documented adrenal lesion who had undergone a LA: 26 using standard-pressure (12-14 mmHg) and 25 using low-pressure (6-8 mmHg) pneumoperitoneum. White blood cells (WBC), peripheral lymphocyte subpopulation, human leucocyte antigen-DR (HLA-DR), neutrophil elastase, interleukin (IL)-6 and IL-1, and C-reactive protein (CRP) were investigated. Significantly higher concentrations of neutrophil elastase, IL-6 and IL-1 and CRP were detected p.o. in the standard-pressure group of patients in comparison with the low-pressure group (P < 0.05). A statistically significant change in HLA-DR expression was recorded p.o. at 24 h, as a reduction of this antigen expressed on the monocyte surface in patients from the standard group; no changes were noted in low-pressure group patients (P < 0.05). This study demonstrated that reducing the pressure of the pneumoperitoneum to 6-8 mmHg during LA reduced p.o. inflammatory response and averted p.o. immunosuppression. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015IAUGA..2258213C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015IAUGA..2258213C">Jellyfish: Observational Properties of Extreme Ram-Pressure Stripping Events in Massive Galaxy Clusters</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Conor, McPartland; Ebeling, Harald; Roediger, Elke 2015-08-01 We investigate the physical origin and observational signatures of extreme ram-pressure stripping (RPS) in 63 massive galaxy clusters at z=0.3-0.7, based on data in the F606W passband obtained with the Advanced Camera for Surveys aboard the Hubble Space Telescope. Using a training set of a dozen ``jellyfish" galaxies identified earlier in the same imaging data, we define quantitative morphological criteria to select candidate galaxies which are similar to known cases of RPS. Considering a sample of 16 ``jellyfish" galaxies (10 of which we present for the first time), we visually derive estimates of the projected direction of motion based on dynamical features such as apparent compression shocks and debris trails. Our findings suggest that the observed events occur primarily at large distances from the cluster core and involve infall trajectories featuring high impact parameters. Simple models of cluster growth show that such trajectories are consistent with two scenarios: 1) galaxy infall along filaments; and 2) infall at high velocities (≥1000 km/s) characteristic of cluster mergers. The observed distribution of events is best described by timescales of ˜few Myr in agreement with recent numerical simulations of RPS. The broader areal coverage of the Hubble Frontier Fields should provide an even larger sample of RPS events to determine the relative contributions of infall and cluster mergers. Prompted by the discovery of several jellyfish galaxies whose brightness in the F606W passband rivals or exceeds that of the respective brightest cluster galaxy, we attempt to constrain the luminosity function of galaxies undergoing RPS. The observed significant excess at the bright end compared to the luminosity functions of blue cluster members strongly suggests enhanced star formation, thus challenging theoretical and numerical studies according to which RPS merely displaces existing star-forming regions. In-depth studies of individual objects will help test our </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19950058595&hterms=atmospheric+pressure&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D50%26Ntt%3Datmospheric%2Bpressure','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19950058595&hterms=atmospheric+pressure&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D50%26Ntt%3Datmospheric%2Bpressure">Atmospheric pressure loading parameters from very long baseline interferometry observations</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Macmillan, D. S.; Gipson, John M. 1994-01-01 Atmospheric mass loading produces a primarily vertical displacement of the Earth's crust. This displacement is correlated with surface pressure and is large enough to be detected by very long baseline interferometry (VLBI) measurements. Using the measured surface pressure at VLBI stations, we have estimated the atmospheric loading term for each station location directly from VLBI data acquired from 1979 to 1992. Our estimates of the vertical sensitivity to change in pressure range from 0 to -0.6 mm/mbar depending on the station. These estimates agree with inverted barometer model calculations (Manabe et al., 1991; vanDam and Herring, 1994) of the vertical displacement sensitivity computed by convolving actual pressure distributions with loading Green's functions. The pressure sensitivity tends to be smaller for stations near the coast, which is consistent with the inverted barometer hypothesis. Applying this estimated pressure loading correction in standard VLBI geodetic analysis improves the repeatability of estimated lengths of 25 out of 37 baselines that were measured at least 50 times. In a root-sum-square (rss) sense, the improvement generally increases with baseline length at a rate of about 0.3 to 0.6 ppb depending on whether the baseline stations are close to the coast. For the 5998-km baseline from Westford, Massachusetts, to Wettzell, Germany, the rss improvement is about 3.6 mm out of 11.0 mm. The average rss reduction of the vertical scatter for inland stations ranges from 2.7 to 5.4 mm. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3985862','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3985862">Observation of Complete Pressure-Jump Protein Refolding in Molecular Dynamics Simulation and Experiment</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> 2015-01-01 Density is an easily adjusted variable in molecular dynamics (MD) simulations. Thus, pressure-jump (P-jump)-induced protein refolding, if it could be made fast enough, would be ideally suited for comparison with MD. Although pressure denaturation perturbs secondary structure less than temperature denaturation, protein refolding after a fast P-jump is not necessarily faster than that after a temperature jump. Recent P-jump refolding experiments on the helix bundle λ-repressor have shown evidence of a <3 μs burst phase, but also of a ∼1.5 ms “slow” phase of refolding, attributed to non-native helical structure frustrating microsecond refolding. Here we show that a λ-repressor mutant is nonetheless capable of refolding in a single explicit solvent MD trajectory in about 19 μs, indicating that the burst phase observed in experiments on the same mutant could produce native protein. The simulation reveals that after about 18.5 μs of conformational sampling, the productive structural rearrangement to the native state does not occur in a single swift step but is spread out over a brief series of helix and loop rearrangements that take about 0.9 μs. Our results support the molecular time scale inferred for λ-repressor from near-downhill folding experiments, where transition-state population can be seen experimentally, and also agrees with the transition-state transit time observed in slower folding proteins by single-molecule spectroscopy. PMID:24437525 </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AGUFMSM11B2309V','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AGUFMSM11B2309V">Tracking a Solar Wind Dynamic Pressure Pulses' Impact Through the Magnetosphere Using the Heliophysics System Observatory</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Vidal-Luengo, S.; Moldwin, M. 2017-12-01 During northward Interplanetary Magnetic Field (IMF) Bz conditions, the magnetosphere acts as a closed "cavity" and reacts to solar wind dynamic pressure pulses more simply than during southward IMF conditions. Effects of solar wind dynamic pressure have been observed as geomagnetic lobe compressions depending on the characteristics of the pressure pulse and the spacecraft location. One of the most important aspects of this study is the incorporation of simultaneous observations by different missions, such as WIND, CLUSTER, THEMIS, MMS, Van Allen Probes and GOES as well as magnetometer ground stations that allow us to map the magnetosphere response at different locations during the propagation of a pressure pulse. In this study we used the SYM-H as an indicator of dynamic pressure pulses occurrence from 2007 to 2016. The selection criteria for events are: (1) the increase in the index must be bigger than 10 [nT] and (2) the rise time must be in less than 5 minutes. Additionally, the events must occur under northward IMF and at the same time at least one spacecraft has to be located in the magnetosphere nightside. Using this methodology we found 66 pressure pulse events for analysis. Most of them can be classified as step function pressure pulses or as sudden impulses (increase followed immediately by a decrease of the dynamic pressure). Under these two categories the results show some systematic signatures depending of the location of the spacecraft. For both kind of pressure pulse signatures, compressions are observed on the dayside. However, on the nightside compressions and/or South-then-North magnetic signatures can be observed for step function like pressure pulses, meanwhile for the sudden impulse kind of pressure pulses the magnetospheric response seems to be less global and more dependent on the local conditions. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://pubs.er.usgs.gov/publication/70137864','USGSPUBS'); return false;" href="https://pubs.er.usgs.gov/publication/70137864">Fluid pressure responses for a Devil's Slide-like system: problem formulation and simulation</a> <a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a> Thomas, Matthew A.; Loague, Keith; Voss, Clifford I. 2015-01-01 This study employs a hydrogeologic simulation approach to investigate subsurface fluid pressures for a landslide-prone section of the central California, USA, coast known as Devil's Slide. Understanding the relative changes in subsurface fluid pressures is important for systems, such as Devil's Slide, where slope creep can be interrupted by episodic slip events. Surface mapping, exploratory core, tunnel excavation records, and dip meter data were leveraged to conceptualize the parameter space for three-dimensional (3D) Devil's Slide-like simulations. Field observations (i.e. seepage meter, water retention, and infiltration experiments; well records; and piezometric data) and groundwater flow simulation (i.e. one-dimensional vertical, transient, and variably saturated) were used to design the boundary conditions for 3D Devil's Slide-like problems. Twenty-four simulations of steady-state saturated subsurface flow were conducted in a concept-development mode. Recharge, heterogeneity, and anisotropy are shown to increase fluid pressures for failure-prone locations by up to 18.1, 4.5, and 1.8% respectively. Previous estimates of slope stability, driven by simple water balances, are significantly improved upon with the fluid pressures reported here. The results, for a Devil's Slide-like system, provide a foundation for future investigations </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28602246','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28602246">Pressure signatures can influence tissue response for individuals supported on an alternating pressure mattress.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Chai, C Y; Sadou, O; Worsley, P R; Bader, D L 2017-08-01 Prolonged mechanical loading can lead to the breakdown of skin and underlying tissues which can, in turn, develop into a pressure ulcer. The benefits of pressure relief and/or redistribution to minimise risk have been well documented. Manufacturers have developed alternating air pressure mattresses (APAMs) to provide periodic relief for individuals on prolonged bed-rest. The present study describes the development of a control system, termed Pneumatic Manager which can vary the signature of an APAM, namely its pressure amplitude, cell profile and cycle period. An experimental array was designed to investigate the effects of varying these parameters, particularly with respect to its ability to maintain skin viability in a group of five healthy volunteers lying in a supine position. Transcutaneous gas (T c PO 2 /T c PCO 2 ) tensions at the sacrum were monitored. In addition, pressures and microclimate parameters at the loaded support interface were also measured. In the majority of test conditions the alternating support produced sacral T c PO 2 values, which either remained relatively high or fluctuated in concert with cycle period providing adequate viability. However, in 46% of cases at the extreme pressure amplitude of 100/0 mmHg, there was compromise to the skin viability at the sacrum, as reflected in depressed T c PO 2 levels associated with an elevation of T c PCO 2 levels above the normal range. In all cases, both the humidity and temperature levels increased during the test period. It is interesting to note that interface pressures at the sacrum rarely exceeded 60 mmHg. Although such studies need to be extended to involve bed-bound individuals, the results provide a design template for the optimum pressure signatures of APAM systems to ensure maintenance of skin viability during pronged loading. Copyright © 2017 Tissue Viability Society. Published by Elsevier Ltd. All rights reserved. </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active">18</li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_19" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active">19</li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="361"> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22357524','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22357524">Exaggerated blood pressure response during exercise treadmill testing: functional and hemodynamic features, and risk factors.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> de Lima, Sandro G; de Albuquerque, Maria de F P M; de Oliveira, João R M; Ayres, Constância F J; da Cunha, José E G; de Oliveira, Danyllo F; de Lemos, Roberta R; de Souza, Manuela B R; e Silva, Odwaldo B 2012-07-01 The factors which contribute to an exaggerated blood pressure response (EBPR) during the exercise treadmill test (ETT) are not wholly understood. The association between the insertion/deletion polymorphisms of the angiotensin-converting enzyme (ACE) and M235T of the angiotensinogen with EBPR during ETT still remains unstudied. To identify and compare the risk factors for hypertension between normotensive subjects with EBPR and those who exhibit a normal curve of blood pressure (BP) during ETT. In a series of EBPR cases from a historical cohort of normotensive individuals, a univariate analysis was performed to estimate the association of the studied factors with BP behavior during ETT. Additionally, logistic multivariate regression was conducted to analyze the joint effects of the variables. P-values above 0.05 were considered statistically significant. From a total of 10,027 analyzed examinations, only 219 met the criteria employed to define EBPR, which resulted in a prevalence of 12.6%. For the systolic component of the BP, hyperreactive subjects displayed a mean age and body mass index (BMI) significantly higher than the others (P=0.002 and <0.001, respectively). No association was observed between the polymorphisms cited above and EBPR. An analysis of the joint effect of variables has indicated that only age (P< 0.001) and BMI (P=0.001) were specifically associated with systolic BP during exercise. Age and BMI were the only factors that independently influenced EBPR during ETT. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1550356','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1550356">Observation of contrast agent response to chirp insonation with a simultaneous optical-acoustical system</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Sun, Yang; Zhao, Shukui; Dayton, Paul A.; Ferrara, Katherine W. 2006-01-01 Rayleigh-Plesset analysis, ultra-high speed photography, and single bubble acoustical recordings have previously been applied independently to characterize the radial oscillation and resulting echoes from a microbubble in response to an ultrasonic pulse. In addition, high speed photography has shown that microbubbles are destroyed over a single pulse or pulse train by diffusion and fragmentation. In order to develop a single model to characterize microbubble echoes based on oscillatory and destructive characteristics, an optical-acoustical system was developed to simultaneously record the optical image and backscattered echo from each microbubble. Combined observation provides the opportunity to compare predictions for oscillation and echoes with experimental results and identify discrepancies due to diffusion or fragmentation. Optimization of agents and insonating pulse parameters may be facilitated with this system. The mean correlation of the predicted and experimental radius-time curves and echoes exceeds 0.7 for the parameters studied here. An important application of this new system is to record and analyze microbubble response to a long pulse where diffusion is shown to occur over the pulse duration. The microbubble response to an increasing or decreasing chirp is evaluated using this new tool. For chirp insonation beginning with the lower center frequency, low frequency modulation of the oscillation envelope was obvious. However, low frequency modulation was not observed in the radial oscillation produced by decreasing chirp insonation. Comparison of the echoes from similar sized microbubbles following increasing and decreasing chirp insonation demonstrated that the echoes were not time-reversed replicas. Using a transmission pressure of 620 kPa, the −6 dB echo length was 0.9 and 1.1 μs for increasing and decreasing chirp insonation, respectively (P = 0.02). The mean power in the low frequency portion of the echoes was 8 (mV)2 and 13 (mV)2 for increasing </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/11499168','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/11499168">Blood pressure and endocrine responses of healthy subjects in cold pressor test after acutely increased dietary sodium intake.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Arjamaa, O; Mäkinen, T; Turunen, L; Huttunen, P; Leppäluoto, J; Vuolteenaho, O; Rintamäki, H 2001-05-01 The objective of the study was to compare blood pressure and endocrine responses in a cold pressure test in young healthy subjects who had shown increased blood pressure during an acutely increased sodium intake. Subjects (n = 53) added 121 mmol sodium into their normal diet for one week. If the mean arterial pressure had increased by a minimum of 5 mmHg compared to the control measure, they were selected for the experiments. The selected subjects (n = 8) were given 121 mmol supplemental sodium d-1 for 14 days after which they immersed the right hand into a cold (+10 degrees C) water bath for 5 min. The blood pressure increased (P < 0.05) during the test and was independent of the sodium intake. The plasma noradrenaline increased from 2.41 +/- 0.38 nmol l-1 to 2.82 +/- 0.42 nmol l-1 (P < 0.05) with normal diet and from 1.85 +/- 0.29 nmol l-1 to 2.40 +/- 0.37 nmol l-1 (P < 0.05) with high sodium diet. The starting concentrations and the endpoint concentrations were statistically similar. The plasma levels of natriuretic peptides (NT-proANP, ANP and BNP) did not change during the test, and the concentrations were independent of the sodium diet. To conclude, acutely increased sodium intake does not change blood pressure or hormonal responses in a cold pressor test in young healthy subjects. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27733385','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27733385">Hormone phase influences sympathetic responses to high levels of lower body negative pressure in young healthy women.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Usselman, Charlotte W; Nielson, Chantelle A; Luchyshyn, Torri A; Gimon, Tamara I; Coverdale, Nicole S; Van Uum, Stan H M; Shoemaker, J Kevin 2016-11-01 We tested the hypothesis that sympathetic responses to baroreceptor unloading may be affected by circulating sex hormones. During lower body negative pressure at -30, -60, and -80 mmHg, muscle sympathetic nerve activity (MSNA), heart rate, and blood pressure were recorded in women who were taking (n = 8) or not taking (n = 9) hormonal contraceptives. All women were tested twice, once during the low-hormone phase (i.e., the early follicular phase of the menstrual cycle and the placebo phase of hormonal contraceptive use), and again during the high-hormone phase (i.e., the midluteal phase of the menstrual cycle and active phase of contraceptive use). During baroreceptor unloading, the reductions in stroke volume and resultant increases in MSNA and total peripheral resistance were greater in high-hormone than low-hormone phases in both groups. When normalized to the fall in stroke volume, increases in MSNA were no longer different between hormone phases. While stroke volume and sympathetic responses were similar between women taking and not taking hormonal contraceptives, mean arterial pressure was maintained during baroreceptor unloading in women not taking hormonal contraceptives but not in women using hormonal contraceptives. These data suggest that differences in sympathetic activation between hormone phases, as elicited by lower body negative pressure, are the result of hormonally mediated changes in the hemodynamic consequences of negative pressure, rather than centrally driven alterations to sympathetic regulation. Copyright © 2016 the American Physiological Society. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5975430','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5975430">Blood Pressure and Renal Responses to Orthostatic Stress Before and After Radiofrequency Renal Denervation in Patients with Resistant Hypertension</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Vuignier, Yann; Grouzmann, Eric; Muller, Olivier; Vakilzadeh, Nima; Faouzi, Mohamed; Maillard, Marc P.; Qanadli, Salah D.; Burnier, Michel; Wuerzner, Grégoire 2018-01-01 Background/Aims In patients with resistant hypertension, renal denervation (RDN) studies have mainly focused their outcomes on blood pressure (BP). The aim of this study was to evaluate the long-term effect of RDN on neurohormonal profiles, renal hemodynamics and sodium excretion in a resting state and during stress induced by lower body negative pressure (LBNP). Materials and methods This was a single center prospective observational study. Norepinephrine, plasma renin activity (PRA), glomerular filtration rate (GFR), renal plasma flow (RPF) and sodium excretion were measured in unstimulated conditions (rest) and after one hour of LBNP at three different time points: before (M0), one (M1) and twelve months (M12) after RDN. Results Thirteen patients with resistant hypertension were included. In the resting state, no differences were observed in norepinephrine, PRA, sodium excretion and mean BP levels after RDN. GFR (78 ± 32 ml/min at M0 vs 66 ± 26 ml/min at M12 (p = 0.012) and filtration fraction (22.6 ±5.4% at M0 vs 15.1 ±5.3% at M12 (p = 0.002)) both decreased after RDN. During LBNP, the magnitude of the mean BP increase was reduced from +6.8 ± 6.6 mm Hg at M0 to +2.3 ± 1.3 mm Hg at M12 (p = 0.005). The LBNP-induced increase in norepinephrine and decrease in GFR and sodium excretion observed before RDN were blunted after the procedure. Conclusion A decrease in GFR and filtration fraction was observed one year after RDN. In addition, our results suggest that RDN blunts not only the norepinephrine but also the mean BP, the GFR and the sodium excretion responses to an orthostatic stress one year after the intervention. Registry number NCT01734096 PMID:29876358 </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013AGUFM.T31F2572K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013AGUFM.T31F2572K">Response to long-period seismic waves recorded by broadband seismometer and pore pressure sensor at IODP Site C0002, Nankai Trough</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Kitada, K.; Araki, E.; Kimura, T.; Saffer, D. M. 2013-12-01 Long term in situ monitoring of seismic activity, slow slip event, and pore fluid behavior around mega earthquake zone is important for understanding the processes of earthquake generation and strain accumulation. In order to characterize the response to long-period seismic waves, we compared waveforms and hydroseismograms recorded by broadband seismometer and pore pressure transducers, respectively, which were installed at IODP Site C0002 in the Nankai Trough Kumano Basin. The borehole monitoring system sensor array at Site C0002 is designed to collect multiparameter observations covering a dynamic range of events, including local microearthquakes, low frequency earthquakes, and large-scale earthquakes similar to the Tonankai earthquake. The suite of sensors for the downhole portion of the observatory includes a broadband seismometer (CMG3TBD, Guralp Systems Ltd.) with sampling rate of 100Hz at the depth of 907mbsf, and four pressure ports connected to pressure gauges located at 948mbsf, 917mbsf, 766mbsf, and at the seafloor. The sampling rate of the data logger was set to 1Hz after successful connection to the DONET seafloor cable network for real-time monitoring on 24 Jan 2013. Since then, we processed 12 earthquakes between a moment magnitude of 6.5 to 8.3. In addition to the comparison of long-period surface waves waveform and pressure data, we compared the records with theoretical strain seismograms. The latter were calculated by normal mode summation using the earth model PREM of Dziewonski and Anderson (1981). A Butterworth bandpass filter was applied to the records with cut-off frequencies of 0.003 and 0.1 Hz. Our initial results indicate that the hydroseismograms correspond well with the vertical rather than the horizontal (radial and transverse) components in seismic data. The observed hydroseismogram have a good correlation with the predicted volumetric strain seismogram, especially for the Okhotsk (2013/05/24 14:17UT, Mw8.3, 632km depth), the Chishima </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24357502','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24357502">Microenvironment is involved in cellular response to hydrostatic pressures during chondrogenesis of mesenchymal stem cells.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Ye, Rui; Hao, Jin; Song, Jinlin; Zhao, Zhihe; Fang, Shanbao; Wang, Yating; Li, Juan 2014-06-01 Chondrocytes integrate numerous microenvironmental cues to mount physiologically relevant differentiation responses, and the regulation of mechanical signaling in chondrogenic differentiation is now coming into intensive focus. To facilitate tissue-engineered chondrogenesis by mechanical strategy, a thorough understanding about the interactional roles of chemical factors under mechanical stimuli in regulating chondrogenesis is in great need. Therefore, this study attempts to investigate the interaction of rat MSCs with their microenvironment by imposing dynamic and static hydrostatic pressure through modulating gaseous tension above the culture medium. Under dynamic pressure, chemical parameters (pH, pO2, and pCO2) were kept in homeostasis. In contrast, pH was remarkably reduced due to increased pCO2 under static pressure. MSCs under the dynamically pressured microenvironment exhibited a strong accumulation of GAG within and outside the alginate beads, while cells under the statically pressured environment lost newly synthesized GAG into the medium with a speed higher than its production. In addition, the synergic influence on expression of chondrogenic genes was more persistent under dynamic pressure than that under static pressure. This temporal contrast was similar to that of activation of endogenous TGF-β1. Taken altogether, it indicates that a loading strategy which can keep a homeostatic chemical microenvironment is preferred, since it might sustain the stimulatory effects of mechanical stimuli on chondrogenesis via activation of endogenous TGF-β1. © 2013 Wiley Periodicals, Inc. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19950051005&hterms=Heart+Rate&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D50%26Ntt%3DHeart%2BRate','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19950051005&hterms=Heart+Rate&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D50%26Ntt%3DHeart%2BRate">Responses of heart rate and blood pressure to KC-135 hyper-gravity</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Satake, Hirotaka; Matsunami, Ken'ichi; Reschke, Millard F. 1992-01-01 Many investigators have clarified the effects of hyper gravitational-inertial forces (G) upon the cardiovascular system, using the centrifugal apparatus with short rotating radius. We investigated the cardiovascular responses to KC-135 hyper-G flight with negligibly small angular velocity. Six normal, healthy subjects 29 to 40 years old (5 males and 1 female) took part in this experiment. Hyper gravitational-inertial force was generated by the KC-135 hyper-G flight, flown in a spiral path with a very long radius of 1.5 miles. Hyper-G was sustained for 3 minutes with 1.8 +Gz in each session and was repeatedly exposed to very subject sitting on a chair 5 times. The preliminary results of blood pressure and R-R interval are discussed. An exposure of 1.8 +Gz stress resulted in a remarkable increase of systolic and diastolic blood pressure, while the pulse pressure did not change and remained equal to the control level regardless of an exposure of hyper-G. These results in blood pressure indicate an increase of resistance in the peripheral vessels, when an exposure of hyper-G was applied. The R-R interval was calculated from ECG. R-R interval in all subjects was changed but not systematically, and R-R interval became obviously shorter during the hyper-G period than during the 1 +Gz control period although R-R interval varied widely in some cases. The coefficient of variation of R-R interval was estimated to determine the autonomic nerve activity, but no significant change was detectable. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23579517','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23579517">A prospective randomized study of systemic inflammation and immune response after laparoscopic nissen fundoplication performed with standard and low-pressure pneumoperitoneum.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Schietroma, Mario; Carlei, Francesco; Cecilia, Emanuela M; Piccione, Federica; Sista, Federico; De Vita, Fabiola; Amicucci, Gianfranco 2013-04-01 The aim of this study was to compare changes in the systemic inflammation and immune response in the early postoperative (p.o.) period after laparoscopic Nissen fundoplication (LNF) was performed with standard-pressure and low-pressure carbon dioxide pneumoperitoneum. We studied 68 patients with documented gastroesophageal reflux disease and who underwent a LNF: 35 using standard-pressure (12 to 14 mmHg) and 33 low-pressure (6 to 8 mmHg) pneumoperitoneum. White blood cells, peripheral lymphocytes subpopulation, human leukocyte antigen-DR, neutrophil elastase, interleukin (IL)-6 and IL-1, and C-reactive protein were investigated. A significantly higher concentration of neutrophil elastase, IL-6 and IL-1, and C-reactive protein was detected postoperatively in the standard-pressure group of patients in comparison with the low-pressure group (P<0.05). A statistically significant change in human leukocyte antigen-DR expression was recorded p.o. at 24 hours, as a reduction of this antigen expressed on monocyte surface in patients from standard group; no changes were noted in low-pressure group patients (P<0.05). This study demonstrated that reducing the pressure of the pneumoperitoneum to 6 to 8 mm Hg during LNF is reduced p.o. inflammatory response and avoided p.o. immunosuppression. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1429074','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1429074">Indirect blood pressure and heart rate measured quickly without observer bias using a semi-automatic machine (auto-manometer)--response to isometric exercise in normal healthy males and its modification by beta-adrenoceptor blockade.</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Nyberg, G 1977-01-01 1 In a double-blind crossover study, six volunteers performed sustained handgrip at 50% of maximal voluntary contraction before and 90 min following oral administration of 0.25 and 100 mg metoprolol tartrate, a beta1 selective adrenoceptor blocking agent. Blood pressure and heart rate were measured with the Auto-Manometer, an electronic semi-automatic device based on the principles of the London School of Hygiene and Tropical Medicine sphygmomanometer. It eliminates observer and digital bias completely, and also records heart rate at the same time as blood pressure is recorded. 2 Resting heart rate fell 15% after 25 mg, 21% after 100 mg and was unchanged after placebo. Systolic blood pressure fell 6% on both doses and was unchanged on placebo. Diastolic pressure did not change with any of the doses. 3 At 1 min of handgrip, heart rate was significantly lower after 25 and 100 mg than before drug or after placebo. There was no difference between the blood pressure levels attained before or after any of the dose levels. The rise of heart rate tended to be somewhat dampened after 100 mg only. The rise in blood pressure was unchanged after any dose compared with before. Images Figure 1 PMID:901695 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/21443013-observability-radiation-pressure-shot-noise-optomechanical-systems','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/21443013-observability-radiation-pressure-shot-noise-optomechanical-systems">Observability of radiation-pressure shot noise in optomechanical systems</a> <a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a> Boerkje, K.; Nunnenkamp, A.; Zwickl, B. M. 2010-07-15 We present a theoretical study of an experiment designed to detect radiation-pressure shot noise in an optomechanical system. Our model consists of a coherently driven optical cavity mode that is coupled to a mechanical oscillator. We examine the cross-correlation between two quadratures of the output field from the cavity. We determine under which circumstances radiation-pressure shot noise can be detected by a measurement of this cross-correlation. This is done in the general case of nonzero detuning between the frequency of the drive and the cavity resonance frequency. We study the qualitative features of the different contributions to the cross-correlator andmore » provide quantitative figures of merit for the relative importance of the radiation-pressure shot noise contribution to other contributions. We also propose a modified setup of this experiment relevant to the 'membrane-in-the-middle' geometry, which potentially can avoid the problems of static bistability and classical noise in the drive.« less </li> <li> <a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA193592','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA193592">Observational/Numerical Study of the Upper Ocean Response to Hurricanes.</a> <a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a> 1987-12-01 current variance within 30-60 km of the storm center. The effect of the stress divergence and Eknan terms on the ocean current response rapidly...observed current variance within 30-60 km of the storm center. The effect of the stress divergence and Ekman terms on the ocean current response rapidly...110 2. M ode Splitting ....................................... IIl 3. M ixing Effects ....................................... 112 4 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24835575','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24835575">Enhanced response to music in pregnancy.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Fritz, Thomas Hans; Ciupek, Marian; Kirkland, Ambika; Ihme, Klas; Guha, Anika; Hoyer, Jana; Villringer, Arno 2014-09-01 Given a possible effect of estrogen on the pleasure-mediating dopaminergic system, musical appreciation in participants whose estrogen levels are naturally elevated during the oral contraceptive cycle and pregnancy has been investigated (n = 32, 15 pregnant, 17 nonpregnant; mean age 27.2). Results show more pronounced blood pressure responses to music in pregnant women. However, estrogen level differences during different phases of oral contraceptive intake did not have any effect, indicating that the observed changes were not related to estrogen. Effects of music on blood pressure were independent of valence, and dissonance elicited the greatest drop in blood pressure. Thus, the enhanced physiological response in pregnant women probably does not reflect a protective mechanism to avoid unpleasantness. Instead, this enhanced response is discussed in terms of a facilitation of prenatal conditioning to acoustical (musical) stimuli. Copyright © 2014 Society for Psychophysiological Research. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/5883104','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/5883104">Growth responses of Neurospora crassa to increased partial pressures of the noble gases and nitrogen.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Buchheit, R G; Schreiner, H R; Doebbler, G F 1966-02-01 Buchheit, R. G. (Union Carbide Corp., Tonawanda, N.Y.), H. R. Schreiner, and G. F. Doebbler. Growth responses of Neurospora crassa to increased partial pressures of the noble gases and nitrogen. J. Bacteriol. 91:622-627. 1966.-Growth rate of the fungus Neurospora crassa depends in part on the nature of metabolically "inert gas" present in its environment. At high partial pressures, the noble gas elements (helium, neon, argon, krypton, and xenon) inhibit growth in the order: Xe > Kr> Ar > Ne > He. Nitrogen (N(2)) closely resembles He in inhibitory effectiveness. Partial pressures required for 50% inhibition of growth were: Xe (0.8 atm), Kr (1.6 atm), Ar (3.8 atm), Ne (35 atm), and He ( approximately 300 atm). With respect to inhibition of growth, the noble gases and N(2) differ qualitatively and quantitatively from the order of effectiveness found with other biological effects, i.e., narcosis, inhibition of insect development, depression of O(2)-dependent radiation sensitivity, and effects on tissue-slice glycolysis and respiration. Partial pressures giving 50% inhibition of N. crassa growth parallel various physical properties (i.e., solubilities, solubility ratios, etc.) of the noble gases. Linear correlation of 50% inhibition pressures to the polarizability and of the logarithm of pressure to the first and second ionization potentials suggests the involvement of weak intermolecular interactions or charge-transfer in the biological activity of the noble gases. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25455885','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25455885">Controlled hydrostatic pressure stress downregulates the expression of ribosomal genes in preimplantation embryos: a possible protection mechanism?</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Bock, I; Raveh-Amit, H; Losonczi, E; Carstea, A C; Feher, A; Mashayekhi, K; Matyas, S; Dinnyes, A; Pribenszky, C 2016-04-01 The efficiency of various assisted reproductive techniques can be improved by preconditioning the gametes and embryos with sublethal hydrostatic pressure treatment. However, the underlying molecular mechanism responsible for this protective effect remains unknown and requires further investigation. Here, we studied the effect of optimised hydrostatic pressure treatment on the global gene expression of mouse oocytes after embryonic genome activation. Based on a gene expression microarray analysis, a significant effect of treatment was observed in 4-cell embryos derived from treated oocytes, revealing a transcriptional footprint of hydrostatic pressure-affected genes. Functional analysis identified numerous genes involved in protein synthesis that were downregulated in 4-cell embryos in response to hydrostatic pressure treatment, suggesting that regulation of translation has a major role in optimised hydrostatic pressure-induced stress tolerance. We present a comprehensive microarray analysis and further delineate a potential mechanism responsible for the protective effect of hydrostatic pressure treatment. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1331268-enhanced-structural-stability-photo-responsiveness-ch3nh3sni3-perovskite-via-pressure-induced-amorphization-recrystallization','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1331268-enhanced-structural-stability-photo-responsiveness-ch3nh3sni3-perovskite-via-pressure-induced-amorphization-recrystallization">Enhanced structural stability and photo responsiveness of CH 3NH 3SnI 3 perovskite via pressure-induced amorphization and recrystallization</a> <a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a> Lu, Xujie; Wang, Yonggang; Stoumpos, Constantinos C.; ... 2016-10-01 An organic–inorganic halide CH 3NH 3SnI 3 perovskite with significantly improved structural stability is obtained via pressure-induced amorphization and recrystallization. In situ high-pressure resistance measurements reveal an increased electrical conductivity by 300% in the pressure-treated perovskite. Photocurrent measurements also reveal a substantial enhancement in visible-light responsiveness. In conclusion, the mechanism underlying the enhanced properties is shown to be associated with the pressure-induced structural modification. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012EGUGA..1410770V','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012EGUGA..1410770V">Integration of Infrasound, Atmospheric Pressure, and Seismic Observations with the NSF EarthScope USArray Transportable Array</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Vernon, F.; Tytell, J.; Hedlin, M. A. H.; Walker, K.; Busby, R.; Woodward, R. 2012-04-01 Earthscope's USArray Transportable Array (TA) network serves as a real-time monitoring and recording platform for both seismic and weather phenomena. To date, most of the approximately 500 TA stations have been retrofitted with VTI SCP1000 MEMS barometric pressure gauges capable of recording data at 1 sample per second (sps). Additionally, over 300 of the TA stations have also been retrofitted with Setra 278 barometric gauges and NCPA infrasound sensors capable of recording data at 1 and 40 sps. While individual seismic events have been successfully researched via the TA network, observations of powerful weather events by the TA network have yet to be embraced by the scientific community. This presentation will focus on case studies involving severe weather passage across portions of the TA network throughout 2011 in order to highlight its viability as a platform for real-time weather monitoring and research. It will also highlight the coupling of atmospheric signals into the seismic observations. Examples of gust front passages and pressure couplets from severe thunderstorms will be presented, as will observations of multiple tornados occurred in the Spring of 2011. These data will demonstrate the overall viability of the TA network for monitoring severe weather events in real-time. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24721929','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24721929">Modulation of blood pressure response to exercise by physical activity and relationship with resting blood pressure during pregnancy.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Bisson, Michèle; Rhéaume, Caroline; Bujold, Emmanuel; Tremblay, Angelo; Marc, Isabelle 2014-07-01 To determine whether physical activity and blood pressure (BP) response to exercise in early pregnancy are related to resting BP at the end of pregnancy. Understanding physiological BP responses to exercise during pregnancy will help in improving BP profile and guiding exercise recommendations in pregnant women. Maternal physical activity, cardiorespiratory fitness (VO2peak) and BP (systolic and diastolic) at rest and during exercise (submaximal and relative response) were assessed at 16 weeks of gestation in 61 normotensive pregnant women. BP at 36 weeks of gestation and obstetrical outcomes were collected from maternal charts. Related to resting DBP at 16 weeks (r = -0.28, P = 0.028), total energy expenditure spend at any physical activity in early pregnancy was also associated with resting SBP at 36 weeks (r = -0.27, P = 0.038). On the contrary, although related to VO2peak (r = -0.57, P < 0.0001) and energy expenditure spent at sports and exercise (r = -0.29, P = 0.024), the relative SBP response to exercise at 16 weeks was not associated with resting BP at 36 weeks. Strongly associated with resting BP at 16 weeks and also with total energy expenditure, submaximal BP response to exercise at 16 weeks was related to resting SBP and DBP at 36 weeks (r = 0.41, P = 0.001 and r = 0.26, P = 0.051, respectively). In normotensive women, physical activity performed in early pregnancy appears to slightly modulate resting BP in early and late pregnancy. However, further investigations are needed to determine which physical activity-related parameter in response to exercise best predicts BP variations during pregnancy. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19880012120','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19880012120">Pressure induced ageing of polymers</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Emri, I.; Knauss, W. G. 1988-01-01 The nonlinearly viscoelastic response of an amorphous homopolymer is considered under aspects of time dependent free volume behavior. In contrast to linearly viscoelastic solids, this model couples shear and volume deformation through a shift function which influences the rate of molecular relaxation or creep. Sample computations produce all those qualitative features one observes normally in uniaxial tension including the rate dependent formation of a yield point as a consequence of the history of an imposed pressure. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015ChPhB..24e8901L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015ChPhB..24e8901L">Transportation-cyber-physical-systems-oriented engine cylinder pressure estimation using high gain observer</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Li, Yong-Fu; Xiao-Pei, Kou; Zheng, Tai-Xiong; Li, Yin-Guo 2015-05-01 In transportation cyber-physical-systems (T-CPS), vehicle-to-vehicle (V2V) communications play an important role in the coordination between individual vehicles as well as between vehicles and the roadside infrastructures, and engine cylinder pressure is significant for engine diagnosis on-line and torque control within the information exchange process under V2V communications. However, the parametric uncertainties caused from measurement noise in T-CPS lead to the dynamic performance deterioration of the engine cylinder pressure estimation. Considering the high accuracy requirement under V2V communications, a high gain observer based on the engine dynamic model is designed to improve the accuracy of pressure estimation. Then, the analyses about convergence, converge speed and stability of the corresponding error model are conducted using the Laplace and Lyapunov method. Finally, results from combination of Simulink with GT-Power based numerical experiments and comparisons demonstrate the effectiveness of the proposed approach with respect to robustness and accuracy. Project supported by the National Natural Science Foundation of China (Grant No. 61304197), the Scientific and Technological Talents of Chongqing, China (Grant No. cstc2014kjrc-qnrc30002), the Key Project of Application and Development of Chongqing, China (Grant No. cstc2014yykfB40001), the Natural Science Funds of Chongqing, China (Grant No. cstc2014jcyjA60003), and the Doctoral Start-up Funds of Chongqing University of Posts and Telecommunications, China (Grant No. A2012-26). </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active">19</li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_20" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active">20</li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="381"> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016AGUFM.T54B..04H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016AGUFM.T54B..04H">Permeability - Fluid Pressure - Stress Relationship in Fault Zones in Shales</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Henry, P.; Guglielmi, Y.; Morereau, A.; Seguy, S.; Castilla, R.; Nussbaum, C.; Dick, P.; Durand, J.; Jaeggi, D.; Donze, F. V.; Tsopela, A. 2016-12-01 Fault permeability is known to depend strongly on stress and fluid pressures. Exponential relationships between permeability and effective pressure have been proposed to approximate fault response to fluid pressure variations. However, the applicability of these largely empirical laws remains questionable, as they do not take into account shear stress and shear strain. A series of experiments using mHPP probes have been performed within fault zones in very low permeability (less than 10-19 m2) Lower Jurassic shale formations at Tournemire (France) and Mont Terri (Switzerland) underground laboratories. These probes allow to monitor 3D displacement between two points anchored to the borehole walls at the same time as fluid pressure and flow rate. In addition, in the Mont-Terri experiment, passive pressure sensors were installed in observation boreholes. Fracture transmissivity was estimated from single borehole pulse test, constant pressure injection tests, and cross-hole tests. It is found that the transmissivity-pressure dependency can be approximated with an exponential law, but only above a pressure threshold that we call the Fracture Opening Threshold (F.O.P). The displacement data show a change of the mechanical response across the F.O.P. The displacement below the F.O.P. is dominated by borehole response, which is mostly elastic. Above F.O.P., the poro-elasto-plastic response of the fractures dominates. Stress determinations based on previous work and on the analysis of slip data from mHPPP probe indicate that the F.O.P. is lower than the least principal stress. Below the F.O.P., uncemented fractures retain some permeability, as pulse tests performed at low pressures yield diffusivities in the range 10-2 to 10-5 m2/s. Overall, this dual behavior appears consistent with the results of CORK experiments performed in accretionary wedge decollements. Results suggest (1) that fault zones become highly permeable when approaching the critical Coulomb threshold (2 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24255092','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24255092">Blood pressure normalization post-jugular venous balloon angioplasty.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Sternberg, Zohara; Grewal, Prabhjot; Cen, Steven; DeBarge-Igoe, Frances; Yu, Jinhee; Arata, Michael 2015-05-01 This study is the first in a series investigating the relationship between autonomic nervous system dysfunction and chronic cerebrospinal venous insufficiency in multiple sclerosis patients. We screened patients for the combined presence of the narrowing of the internal jugular veins and symptoms of autonomic nervous system dysfunction (fatigue, cognitive dysfunction, sleeping disorders, headache, thermal intolerance, bowel/bladder dysfunction) and determined systolic and diastolic blood pressure responses to balloon angioplasty. The criteria for eligibility for balloon angioplasty intervention included ≥ 50% narrowing in one or both internal jugular veins, as determined by the magnetic resonance venography, and ≥ 3 clinical symptoms of autonomic nervous system dysfunction. Blood pressure was measured at baseline and post-balloon angioplasty. Among patients who were screened, 91% were identified as having internal jugular veins narrowing (with obstructing lesions) combined with the presence of three or more symptoms of autonomic nervous system dysfunction. Balloon angioplasty reduced the average systolic and diastolic blood pressure. However, blood pressure categorization showed a biphasic response to balloon angioplasty. The procedure increased blood pressure in multiple sclerosis patients who presented with baseline blood pressure within lower limits of normal ranges (systolic ≤ 105 mmHg, diastolic ≤ 70 mmHg) but decreased blood pressure in patients with baseline blood pressure above normal ranges (systolic ≥ 130 mmHg, diastolic ≥ 80 mmHg). In addition, gender differences in baseline blood pressure subcategories were observed. The coexistence of internal jugular veins narrowing and symptoms of autonomic nervous system dysfunction suggests that the two phenomena may be related. Balloon angioplasty corrects blood pressure deviation in multiple sclerosis patients undergoing internal jugular vein dilation. Further studies should investigate the </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24557006','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24557006">Response characteristics for thermal and pressure devices commonly used for monitoring nasal and oral airflow during sleep studies.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Gehring, J M; Cho, J-G; Wheatley, J R; Amis, T C 2014-03-01 We examined thermocouple and pressure cannulae responses to oral and nasal airflow using a polyester model of a human face, with patent nasal and oral orifices instrumented with a dual thermocouple (F-ONT2A, Grass) or a dual cannula (0588, Braebon) pressure transducer (± 10 cm H2O, Celesco) system. Tidal airflow was generated using a dual compartment facemask with pneumotachographs (Fleisch 2) connected to the model orifices. During nasal breathing: thermocouple amplitude = 0.38 Ln [pneumotachograph amplitude] + 1.31 and pressure cannula amplitude = 0.93 [pneumotachograph amplitude](2.15); during oral breathing: thermocouple amplitude = 0.44 Ln [pneumotachograph amplitude] + 1.07 and pressure cannula amplitude = 0.33 [pneumotachograph amplitude](1.72); (all range ∼ 0.1-∼ 4.0 L s(-1); r(2) > 0.7). For pneumotachograph amplitudes <1 L s(-1) (linear model) change in thermocouple amplitude/unit change in pneumotachograph amplitude was similar for nasal and oral airflow, whereas nasal pressure cannula amplitude/unit change in pneumotachograph amplitude was almost four times that for oral. Increasing oral orifice area from 0.33 cm(2) to 2.15 cm(2) increased oral thermocouple amplitude/unit change in pneumotachograph amplitude by ∼ 58% but decreased pressure cannula amplitude/unit change in pneumotachograph amplitude by 49%. For pneumotachograph amplitudes up to 1 L s(-1), alterations in inspiratory/expiratory ratios or total respiratory time did not affect the sensitivity of either nasal or oral pressure cannulae or the nasal thermocouple, but the oral thermocouple sensitivity was influenced by respiratory cycle time. Different nasal and oral responses influence the ability of these systems to quantitatively assess nasal and oral airflow and oro-nasal airflow partitioning. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://pubs.er.usgs.gov/publication/70025130','USGSPUBS'); return false;" href="https://pubs.er.usgs.gov/publication/70025130">A mechanism for sustained groundwater pressure changes induced by distant earthquakes</a> <a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a> Brodsky, E.E.; Roeloffs, E.; Woodcock, D.; Gall, I.; Manga, M. 2003-01-01 Large sustained well water level changes (>10 cm) in response to distant (more than hundreds of kilometers) earthquakes have proven enigmatic for over 30 years. Here we use high sampling rates at a well near Grants Pass, Oregon, to perform the first simultaneous analysis of both the dynamic response of water level and sustained changes, or steps. We observe a factor of 40 increase in the ratio of water level amplitude to seismic wave ground velocity during a sudden coseismic step. On the basis of this observation we propose a new model for coseismic pore pressure steps in which a temporary barrier deposited by groundwater flow is entrained and removed by the more rapid flow induced by the seismic waves. In hydrothermal areas, this mechanism could lead to 4 ?? 10-2 MPa pressure changes and triggered seismicity. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20010125146&hterms=stress+relationship&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D50%26Ntt%3Dstress%2Brelationship','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20010125146&hterms=stress+relationship&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D50%26Ntt%3Dstress%2Brelationship">Peripheral Microvascular Responses to Whole-Body Tilting, G(z) Centrifugation, and Lower Body Negative Pressure Stresses in Humans</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Breit, G. A.; Watenpaugh, D. E.; Buckley, T. M.; Ballard, R. E.; Murthy, G.; Hargens, A. R. 1994-01-01 The response of the cutaneous microcirculation to orthostatic stress varies along the length of the body due to the interaction of central controls with regional responses to local blood pressure. We hypothesize that artificial orthostatic stresses such as Gz centrifugation and LBNP differ from whole-body tilting in terms of the distribution of microvascular blood flow. Cutaneous microvascular flows were measured by laser Doppler flowmetry at the neck, thigh, and leg of 15 normal subjects. Volunteers underwent stepwise head-up tilt (HUT) and short- and long-arm centrifugation protocols from supine control (0 Gz) to 0.2, 0.4, 0.6, 0.8, 1.0, 0.8, 0.6, 0.4, 0.2, and 0 Gz at the feet, for 30-s periods with 10-s transitions between levels. The same subjects underwent a corresponding supine LBNP protocol, up to 100 mmHg (in 20 mmHg increments) and back to zero pressure, which produced transmural pressure across blood vessels in the foot approximately equal to the HUT protocol. In general, application of all orthostatic stresses produced significant flow reductions in the lower body (p less than 0.05) and inconsistent changes in the neck. At low levels of each stress (0.4 Gz, 40 mmHg), LBNP generated the greatest relative reduction in flow in the lower body (-66.9+/-5.7%, thigh; -60.6 +/-5.7%, leg, mean +/- SE). HUT caused a less severe flow reduction than LBNP at the thigh and leg (-39.9 +/- 8.1% and -55.9+/-4.8%), while the effects induced by both forms of centrifugation were the least profound. Higher levels of each stress generally resulted in similar responses. These responses exhibit a consistent relationship to hypothesized changes in local microvascular transmural pressure, suggesting that myogenic and veno-arteriolar reflexes play a significant role in determining microvascular perfusion during orthostatic stress. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24224473','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24224473">Determination of extremely high pressure tolerance of brine shrimp larvae by using a new pressure chamber system.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Seo, Mihye; Koyama, Sumihiro; Toyofuku, Takashi; Kojima, Shigeaki; Watanabe, Hiromi 2013-11-01 Hydrostatic pressure is the only one of a range of environmental parameters (water temperature, salinity, light availability, and so on) that increases in proportion with depth. Pressure tolerance is therefore essential to understand the foundation of populations and current diversity of faunal compositions at various depths. In the present study, we used a newly developed pressure chamber system to examine changes in larval activity of the salt-lake crustacean, Artemia franciscana, in response to a range of hydrostatic pressures. We showed that A. franciscana larvae were able to survive for a short period at pressures of ≤ 60 MPa (approximately equal to the pressure of 6000 m deep). At a pressure of > 20 MPa, larval motor ability was suppressed, but not lost. Meanwhile, at a pressure of > 40 MPa, some of the larval motor ability was lost without recovery after decompression. For all experiments, discordance of movement and timing between right and left appendages, was observed at pressures of > 20 MPa. Our results indicate that the limit of pressure for sustaining active behavior of A. franciscana larvae is ∼20 MPa, whereas the limit of pressure for survival is within the range 30-60 MPa. Thus, members of the genus Artemia possess the ability to resist a higher range of pressures than their natural habitat depth. Our findings demonstrated an example of an organism capable of invading deeper environment in terms of physical pressure tolerance, and indicate the need and importance of pressure study as an experimental method. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2002AIPC..620.1149B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2002AIPC..620.1149B">PVDF Gauge Piezoelectric Response under Two-Stage Light Gas Gun Impact Loading</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Bauer, Francois 2002-07-01 Stress gauges based on ferroelectric polymer (PVDF) studies under very high pressure shock compression have shown that the piezoelectric response exhibits a precise reproducible behavior up to 25 GPa. Shock pressure profiles obtained with "in situ" PVDF gauges in porous H.E. (Formex) in a detonation regime have been achieved. Observations of a fast superpressure of a few nanoseconds followed by a pressure release have raised the question of the loading path dependence of the piezoelectric response of PVDF at high shock pressure levels. Consequently, studies of the piezoelectric behavior of PVDF gauges under impact loading using a two-stage light gas gun have been conducted recently. Symmetric impact as well as non symmetric impact and reverse impact techniques have been achieved. Strong viscoplastic behavior of some materials is observed. In typical experiments, the piezoelectric response of PVDF at shock equilibrium could be determined. These results show that the PVDF response appears independent of the loading path up to 30 GPa. Accurate measurements in situ H.E. are also reported with very low inductance PVDF gauges. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4309085','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4309085">Cyclooxygenases 1 and 2 Differentially Regulate Blood Pressure and Cerebrovascular Responses to Acute and Chronic Intermittent Hypoxia: Implications for Sleep Apnea</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Beaudin, Andrew E.; Pun, Matiram; Yang, Christina; Nicholl, David D. M.; Steinback, Craig D.; Slater, Donna M.; Wynne‐Edwards, Katherine E.; Hanly, Patrick J.; Ahmed, Sofia B.; Poulin, Marc J. 2014-01-01 Background Obstructive sleep apnea (OSA) is associated with increased risk of cardiovascular and cerebrovascular disease resulting from intermittent hypoxia (IH)‐induced inflammation. Cyclooxygenase (COX)‐formed prostanoids mediate the inflammatory response, and regulate blood pressure and cerebral blood flow (CBF), but their role in blood pressure and CBF responses to IH is unknown. Therefore, this study's objective was to determine the role of prostanoids in cardiovascular and cerebrovascular responses to IH. Methods and Results Twelve healthy, male participants underwent three, 6‐hour IH exposures. For 4 days before each IH exposure, participants ingested a placebo, indomethacin (nonselective COX inhibitor), or Celebrex® (selective COX‐2 inhibitor) in a double‐blind, randomized, crossover study design. Pre‐ and post‐IH blood pressure, CBF, and urinary prostanoids were assessed. Additionally, blood pressure and urinary prostanoids were assessed in newly diagnosed, untreated OSA patients (n=33). Nonselective COX inhibition increased pre‐IH blood pressure (P≤0.04) and decreased pre‐IH CBF (P=0.04) while neither physiological variable was affected by COX‐2 inhibition (P≥0.90). Post‐IH, MAP was elevated (P≤0.05) and CBF was unchanged with placebo and nonselective COX inhibition. Selective COX‐2 inhibition abrogated the IH‐induced MAP increase (P=0.19), but resulted in lower post‐IH CBF (P=0.01). Prostanoids were unaffected by IH, except prostaglandin E2 was elevated with the placebo (P=0.02). Finally, OSA patients had elevated blood pressure (P≤0.4) and COX‐1 formed thromboxane A2 concentrations (P=0.02). Conclusions COX‐2 and COX‐1 have divergent roles in modulating vascular responses to acute and chronic IH. Moreover, COX‐1 inhibition may mitigate cardiovascular and cerebrovascular morbidity in OSA. Clinical Trial Registration URL: www.clinicaltrials.gov. Unique identifier: NCT01280006 PMID:24815497 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19840057987&hterms=mary+conner&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Dmary%2Bconner','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19840057987&hterms=mary+conner&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Dmary%2Bconner">State deadbeat response and observability in multi-modal systems</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Conner, L. T., Jr.; Stanford, D. P. 1984-01-01 Two aspects of multimodal systems are examined. It is shown that any completely controllable system with state dimension n not exceeding three allows a choice of feedback matrices resulting in a state deadbeat response. Some of the results presented here are valid for arbitrary n, and it is suggested that for all n the state deadbeat response can be obtained under the hypothesis of complete controllability. The controllability canonical form for a multimodal system is refined by introducing a notion of observability which is dual to controllability for these systems. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28957819','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28957819">Exaggerated blood pressure response to exercise and late-onset hypertension in young adults.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Yzaguirre, Ignasi; Grazioli, Gonzalo; Domenech, Mónica; Vinuesa, Antonio; Pi, Ramon; Gutierrez, Josep; Coca, Antonio; Brugada, Josep; Sitges, Marta 2017-12-01 Exaggerated blood pressure response (EBPR) during exercise has been associated with an increased risk of incidental systemic hypertension and cardiovascular morbidity; however, there is no consensus definition of EBPR. We aimed to determine which marker best defines EBPR during exercise and to predict the long-term development of hypertension in individuals younger than 50 years. We reviewed 107 exercise tests performed in 1992, applied several reported methods to define EBPR at moderate and maximum exercise, and contacted the patients by telephone 20 years after the test to verify hypertension status. Finally, we determined which definition best predicted incidental hypertension at 20-year follow-up. The mean age of the participants at the time of exercise testing was 25.7±11.1 years. Logistic regression showed a significant association of diastolic blood pressure of more than 95 mmHg at peak exercise and systolic pressure more than 180 mmHg at moderate exercise with new-onset hypertension at 20-year follow-up [odds ratio: 6.3 (2.09-18.9) and odds ratio: 7.09 (2.31-21.7), respectively]. If EBPR was present, as defined by at least one of these parameters, the probability of incidental later onset hypertension was 70%. In our population, diastolic blood pressure of more than 95 mmHg at maximum exercise or systolic blood pressure more than 180 mmHg at moderate-intensity exercise (100 W) were the best predictors of new-onset hypertension at long-term follow-up. Individuals with EBPR according to these criteria should be monitored closely to detect the early development of hypertension. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/7369390','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/7369390">Comparison of theoretical and observed pressure profiles in geothermal wells</a> <a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a> Marquez M, R. Two-phase water-steam flow conditions in geothermal wells are studied aimed at predicting pressure drops in these wells. Five prediction methods were selected to be analyzed and compared with each other and with actual pressure measurements. These five correlations were tested on five wells: three in New Zealand, one in Mexico, and one in the Philippines. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20110008441','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20110008441">Measuring Fluctuating Pressure Levels and Vibration Response in a Jet Plume</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Osterholt, Douglas J.; Knox, Douglas M. 2011-01-01 The characterization of loads due to solid rocket motor plume impingement allows for moreaccurate analyses of components subjected to such an environment. Typically, test verification of predicted loads due to these conditions is widely overlooked or unsuccessful. ATA Engineering, Inc., performed testing during a solid rocket motor firing to obtain acceleration and pressure responses in the hydrodynamic field surrounding the jet plume. The test environment necessitated a robust design to facilitate measurements being made in close proximity to the jet plume. This paper presents the process of designing a test fixture and an instrumentation package that could withstand the solid rocket plume environment and protect the required instrumentation. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20090026576','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20090026576">Implications of Dynamic Pressure Transducer Mounting Variations on Measurements in Pyrotechnic Test Apparatus</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Dibbern, Andreas; Crisafulli, Jeffrey; Hagopia, Michael; McDougle, Stephen H.; Saulsberry, Regor L. 2009-01-01 Accurate dynamic pressure measurements are often difficult to make within small pyrotechnic devices, and transducer mounting difficulties can cause data anomalies that lead to erroneous conclusions. Delayed initial pressure response followed by data ringing has been observed when using miniaturized pressure transducer mounting adapters required to interface transducers to small test chambers. This delayed pressure response and ringing, combined with a high data acquisition rate, has complicated data analysis. This paper compares the output signal characteristics from different pressure transducer mounting options, where the passage distance from the transducer face to the pyrotechnic chamber is varied in length and diameter. By analyzing the data and understating the associated system dynamics, a more realistic understanding of the actual dynamic pressure variations is achieved. Three pressure transducer mounting configurations (elongated, standard, and face/flush mount) were simultaneously tested using NASA standard initiators in closed volume pressure bombs. This paper also presents results of these pressure transducer mounting configurations as a result of a larger NASA Engineering and Safety Center pyrovalve test project. Results from these tests indicate the improved performance of using face/flush mounted pressure transducers in this application. This type of mounting improved initial pressure measurement response time by approximately 19 s over standard adapter mounting, eliminating most of the lag time; provided a near step-function type initial pressure increase; and greatly reduced data ringing in high data acquisition rate systems. The paper goes on to discuss other issues associated with the firing and instrumentation that are important for the tester to understand. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27514760','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27514760">Enhanced Structural Stability and Photo Responsiveness of CH3 NH3 SnI3 Perovskite via Pressure-Induced Amorphization and Recrystallization.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Lü, Xujie; Wang, Yonggang; Stoumpos, Constantinos C; Hu, Qingyang; Guo, Xiaofeng; Chen, Haijie; Yang, Liuxiang; Smith, Jesse S; Yang, Wenge; Zhao, Yusheng; Xu, Hongwu; Kanatzidis, Mercouri G; Jia, Quanxi 2016-10-01 An organic-inorganic halide CH 3 NH 3 SnI 3 perovskite with significantly improved structural stability is obtained via pressure-induced amorphization and recrystallization. In situ high-pressure resistance measurements reveal an increased electrical conductivity by 300% in the pressure-treated perovskite. Photocurrent measurements also reveal a substantial enhancement in visible-light responsiveness. The mechanism underlying the enhanced properties is shown to be associated with the pressure-induced structural modification. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=314905','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=314905">Growth Responses of Neurospora crassa to Increased Partial Pressures of the Noble Gases and Nitrogen</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Buchheit, R. G.; Schreiner, H. R.; Doebbler, G. F. 1966-01-01 Buchheit, R. G. (Union Carbide Corp., Tonawanda, N.Y.), H. R. Schreiner, and G. F. Doebbler. Growth responses of Neurospora crassa to increased partial pressures of the noble gases and nitrogen. J. Bacteriol. 91:622–627. 1966.—Growth rate of the fungus Neurospora crassa depends in part on the nature of metabolically “inert gas” present in its environment. At high partial pressures, the noble gas elements (helium, neon, argon, krypton, and xenon) inhibit growth in the order: Xe > Kr> Ar ≫ Ne ≫ He. Nitrogen (N2) closely resembles He in inhibitory effectiveness. Partial pressures required for 50% inhibition of growth were: Xe (0.8 atm), Kr (1.6 atm), Ar (3.8 atm), Ne (35 atm), and He (∼ 300 atm). With respect to inhibition of growth, the noble gases and N2 differ qualitatively and quantitatively from the order of effectiveness found with other biological effects, i.e., narcosis, inhibition of insect development, depression of O2-dependent radiation sensitivity, and effects on tissue-slice glycolysis and respiration. Partial pressures giving 50% inhibition of N. crassa growth parallel various physical properties (i.e., solubilities, solubility ratios, etc.) of the noble gases. Linear correlation of 50% inhibition pressures to the polarizability and of the logarithm of pressure to the first and second ionization potentials suggests the involvement of weak intermolecular interactions or charge-transfer in the biological activity of the noble gases. PMID:5883104 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20059898','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20059898">Casein micelle dissociation in skim milk during high-pressure treatment: effects of pressure, pH, and temperature.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Orlien, V; Boserup, L; Olsen, K 2010-01-01 The effect of pH (from 5.5 to 7.5) and temperature (from 5 to 40 degrees C) on the turbidity of reconstituted skim milk powder was investigated at ambient pressure and in situ under pressure (up to 500MPa) by measurement of light scattering. High-pressure treatment reduced the turbidity of milk for all combinations of pH and temperature due to micelle dissociation. The turbidity profiles had a characteristic sigmoidal shape in which almost no effect on turbidity was observed at low pressures (100MPa), followed by a stronger pressure dependency over a pressure range of 150MPa during which turbidity decreased extremely. From the turbidity profiles, the threshold pressure for disruption of micelle integrity was determined and ranged from 150MPa at low pH to 350-400MPa at high pH. The threshold pressure diagram clearly showed a relationship between the barostability of casein micelles and pH, whereas almost no effect of temperature was shown. This remarkable pH effect was a consequence of pressure-induced changes in the electrostatic interactions between colloidal calcium phosphate and the caseins responsible for maintaining micellar structure and was explained by a shift in the calcium phosphate balance in the micelle-serum system. Accordingly, a mechanism for high pressure-induced disruption of micelle integrity is suggested in which the state of calcium plays a crucial role in the micelle dissociation process. Copyright 2010 American Dairy Science Association. Published by Elsevier Inc. All rights reserved. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16020945','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16020945">Baseline neuropsychological profile and cognitive response to cerebrospinal fluid shunting for idiopathic normal pressure hydrocephalus.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Thomas, George; McGirt, Matthew J; Woodworth, Graeme; Heidler, Jennifer; Rigamonti, Daniele; Hillis, Argye E; Williams, Michael A 2005-01-01 To evaluate neurocognitive changes and predict neurocognitive outcome after ventriculoperitoneal shunting for idiopathic normal pressure hydrocephalus (INPH). Reports of neurocognitive response to shunting have been variable and studies that predict cognitive outcomes after shunting are limited. We reviewed our experience with cognitive outcomes for INPH patients who were selected for shunting based on abnormal cerebrospinal fluid (CSF) pressure monitoring and positive response in any of the NPH symptoms following large volume CSF drainage. Forty-two INPH patients underwent neurocognitive testing and Folstein Mini-Mental State Examination (MMSE) prior to shunting. Neurocognitive testing or MMSEwere performed at least 3 months after shunt insertion. Significant improvement in a neurocognitive subtest was defined as improvement by one standard deviation (1 SD) for the patient's age, sex and education level. Significant improvement in overall neurocognitive outcome was defined as a 4-point improvement in MMSE or improvement by 1 SD in 50% of the administered neurocognitive subtests. Nonparametric tests were used to assess changes. Predictors of outcome were assessed via logistic regression analysis. Twenty-two patients (52.3%) showed overall neurocognitive improvement, and significant improvement was seen in tests of verbal memory and psychomotor speed. Predictive analysis showed that patients scoring more than 1 SD below mean at baseline on verbal memory immediate recall were fourfold less likely to show overall cognitive improvement, and sixfold less likely if also associated with visuoconstructional deficit or executive dysfunction. Verbal memory scores at baseline were higher in patients who showed overall cognitive improvement. Shunting INPH patients on the basis of CSF pressure monitoring and drainage response shows a significant rate of cognitive improvement, and baseline neurocognitive test scores may distinguish patients likely to respond to shunt surgery </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19564821','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19564821">The influence of age and diabetes on the skin blood flow response to local pressure.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Petrofsky, Jerrold S; Bains, Gurinder S; Prowse, Michelle; Mc Lellan, Katie; Ethiraju, Gomathi; Lee, Scott; Gunda, Shashi; Lohman, Everett; Schwab, Ernie 2009-07-01 Previous data has shown that when pressure is applied to the skin of the ankle and on the foot, there is a reactive increase in circulation. In the present investigation, these studies were expanded to look at the response of the hand, back, and foot to applied pressure. Ten young subjects whose average age was 26.5+/-3.3 yrs, 10 older subjects whose average age was 73.3+/-19.7 yrs and 10 people with diabetes whose average age was 60.1+/-5.7 yrs participated in the study. There was no statistical difference in the height or weight of the subjects. Hemoglobin A1c of the group with Diabetes averaged 6.98+/-1.15% with the mean duration of diabetes 13.6+/-9.5 yrs. An infrared laser Doppler flow meter was used to measure circulation on the hand, lower back, and on the bottom of the foot during applications of pressure at 15, 30, 45, and 60 kPa. For all three areas of the body, circulation was significantly less in the group with diabetes than the other two groups (p<0.05). When pressure was applied at 15 kPa, the blood flow to the skin initially decreased, but then increased in the younger subjects and in the older subjects but did not increase in subjects with diabetes for any area of the body. Further, after pressure was released, for any of the four pressures examined here, while the younger subjects showed a pronounced reactive hyperemia, subjects with diabetes showed a diminished hyperemia not proportional to the pressure that was applied. It appears that the normal protective mechanism of a pressure induced hyperemia is absent or diminished in patients with diabetes with more effect on the periphery than on the core area of the body. More importantly, after pressure was applied and released, subjects with diabetes lacked a proportional hyperemia to recovery form the transient ischemia of the pressure. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1999CPL...311..126A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1999CPL...311..126A">The temperature dependence of the pressure switching of Jahn Teller deformation in the deuterated ammonium copper Tutton salt</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Augustyniak, Maria A.; Krupski, Marcin 1999-09-01 The pressure switch of the Jahn-Teller deformation direction in (ND 4) 2Cu(SO 4) 2·6D 2O was investigated in the temperature range 130-320 K. Below 295 K, the new, pressure-induced phase, is stable under ambient pressure. Switching back is observed on heating to above 297 K. In the range 150-295 K a strong temperature dependence of the switching pressure (from 24 to 450 MPa) is observed. Below 150 K, the switching process is slow and a coexistence of two phases is observed. We conclude that the switch of the Cu(D 2O) 6 complex deformation direction is the Jahn-Teller response to the changes in the hydrogen bond system. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23904049','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23904049">Methodology and evaluation of intracranial pressure response in rats exposed to complex shock waves.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Dal Cengio Leonardi, Alessandra; Keane, Nickolas J; Hay, Kathryn; Ryan, Anne G; Bir, Cynthia A; VandeVord, Pamela J 2013-12-01 Studies on blast neurotrauma have focused on investigating the effects of exposure to free-field blast representing the simplest form of blast threat scenario without considering any reflecting surfaces. However, in reality personnel are often located within enclosures or nearby reflecting walls causing a complex blast environment, that is, involving shock reflections and/or compound waves from different directions. The purpose of this study was to design a complex wave testing system and perform a preliminary investigation of the intracranial pressure (ICP) response of rats exposed to a complex blast wave environment (CBWE). The effects of head orientation in the same environment were also explored. Furthermore, since it is hypothesized that exposure to a CBWE would be more injurious as compared to a free-field blast wave environment (FFBWE), a histological comparison of hippocampal injury (cleaved caspase-3 and glial fibrillary acidic protein (GFAP)) was conducted in both environments. Results demonstrated that, regardless of orientation, peak ICP values were significantly elevated over the peak static air overpressure. Qualitative differences could be noticed compared to the ICP response in rats exposed to simulated FFBWE. In the CBWE scenario, after the initial loading the skull/brain system was not allowed to return to rest and was loaded again reaching high ICP values. Furthermore, results indicated consistent and distinct ICP-time profiles according to orientation, as well as distinctive values of impulse associated with each orientation. Histologically, cleaved caspase-3 positive cells were significantly increased in the CBWE as compared to the FFBWE. Overall, these findings suggest that the geometry of the skull and the way sutures are distributed in the rats are responsible for the difference in the stresses observed. Moreover, this increase stress contributes to correlation of increased injury in the CBWE. </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active">20</li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_21" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active">21</li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="401"> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2535851','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2535851">Association between Blood Pressure Responses to Cold Pressor Test and Dietary Sodium Intervention in the Chinese Population</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Chen, Jing; Gu, Dongfeng; Jaquish, Cashell E.; Chen, Chung-Shiuan; Rao, DC; Liu, Depei; Hixson, James E.; Hamm, L. Lee; Gu, C. Charles; Whelton, Paul K.; He, Jiang 2008-01-01 Background Blood pressure (BP) responses to the cold pressor test (CPT) and to dietary sodium intake might be related to the risk of hypertension. We examined the association between BP responses to the CPT and to dietary sodium and potassium interventions. Methods The CPT and dietary intervention were conducted among 1,906 study participants in rural China. The dietary intervention included three 7-day periods of low-sodium-feeding (51.3 mmol/day), high-sodium-feeding (307.8 mmol/day), and high-sodium-feeding plus potassium-supplementation (60 mmol/day). A total of 9 BP measurements were obtained during the 3-day baseline observation and the last 3 days of each intervention using a random-zero sphygmomanometer. Results BP response to the CPT was significantly associated with BP changes during the sodium and potassium interventions (all p<0.0001). Compared to the lowest quartile of BP response to the CPT, systolic BP changes (95% confident interval) for the top 3 quartiles, respectively, were −2.02 (−2.87, −1.16), −3.17 (−4.05, −2.28), and −5.98 (−6.89, −5.08) mm Hg during the low-sodium intervention. Corresponding systolic BP changes during the high-sodium intervention were 0.40 (−0.36, 1.16), 0.44 (−0.35, 1.22), and 2.30 (1.50, 3.10) mm Hg, and during the potassium-supplementation were −0.26 (−0.99, 0.46), −0.95 (−1.70, −0.20), and −1.59 (−2.36, −0.83) mm Hg, respectively. Conclusions These results indicated that BP response to the CPT was associated with salt-sensitivity and potassium-sensitivity. Furthermore, a low-sodium or high-potassium diet might be more effective to lower BP among individuals with high responses to the CPT. PMID:18779460 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23161359','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23161359">Predictive value of pulse pressure variation for fluid responsiveness in septic patients using lung-protective ventilation strategies.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Freitas, F G R; Bafi, A T; Nascente, A P M; Assunção, M; Mazza, B; Azevedo, L C P; Machado, F R 2013-03-01 The applicability of pulse pressure variation (ΔPP) to predict fluid responsiveness using lung-protective ventilation strategies is uncertain in clinical practice. We designed this study to evaluate the accuracy of this parameter in predicting the fluid responsiveness of septic patients ventilated with low tidal volumes (TV) (6 ml kg(-1)). Forty patients after the resuscitation phase of severe sepsis and septic shock who were mechanically ventilated with 6 ml kg(-1) were included. The ΔPP was obtained automatically at baseline and after a standardized fluid challenge (7 ml kg(-1)). Patients whose cardiac output increased by more than 15% were considered fluid responders. The predictive values of ΔPP and static variables [right atrial pressure (RAP) and pulmonary artery occlusion pressure (PAOP)] were evaluated through a receiver operating characteristic (ROC) curve analysis. Thirty-four patients had characteristics consistent with acute lung injury or acute respiratory distress syndrome and were ventilated with high levels of PEEP [median (inter-quartile range) 10.0 (10.0-13.5)]. Nineteen patients were considered fluid responders. The RAP and PAOP significantly increased, and ΔPP significantly decreased after volume expansion. The ΔPP performance [ROC curve area: 0.91 (0.82-1.0)] was better than that of the RAP [ROC curve area: 0.73 (0.59-0.90)] and pulmonary artery occlusion pressure [ROC curve area: 0.58 (0.40-0.76)]. The ROC curve analysis revealed that the best cut-off for ΔPP was 6.5%, with a sensitivity of 0.89, specificity of 0.90, positive predictive value of 0.89, and negative predictive value of 0.90. Automatized ΔPP accurately predicted fluid responsiveness in septic patients ventilated with low TV. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4154887','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4154887">Cerebral responses to innocuous somatic pressure stimulation following aerobic exercise rehabilitation in chronic pain patients: a functional magnetic resonance imaging study</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Micalos, Peter S; Korgaonkar, Mayuresh S; Drinkwater, Eric J; Cannon, Jack; Marino, Frank E 2014-01-01 Objective The purpose of this research was to assess the functional brain activity and perceptual rating of innocuous somatic pressure stimulation before and after exercise rehabilitation in patients with chronic pain. Materials and methods Eleven chronic pain patients and eight healthy pain-free controls completed 12 weeks of supervised aerobic exercise intervention. Perceptual rating of standardized somatic pressure stimulation (2 kg) on the right anterior mid-thigh and brain responses during functional magnetic resonance imaging (fMRI) were assessed at pre- and postexercise rehabilitation. Results There was a significant difference in the perceptual rating of innocuous somatic pressure stimulation between the chronic pain and control groups (P=0.02) but no difference following exercise rehabilitation. Whole brain voxel-wise analysis with correction for multiple comparisons revealed trends for differences in fMRI responses between the chronic pain and control groups in the superior temporal gyrus (chronic pain > control, corrected P=0.30), thalamus, and caudate (control > chronic, corrected P=0.23). Repeated measures of the regions of interest (5 mm radius) for blood oxygen level-dependent signal response revealed trend differences for superior temporal gyrus (P=0.06), thalamus (P=0.04), and caudate (P=0.21). Group-by-time interactions revealed trend differences in the caudate (P=0.10) and superior temporal gyrus (P=0.29). Conclusion Augmented perceptual and brain responses to innocuous somatic pressure stimulation were shown in the chronic pain group compared to the control group; however, 12-weeks of exercise rehabilitation did not significantly attenuate these responses. PMID:25210471 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3465849','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3465849">Intracranial Pressure Response to Non-Penetrating Ballistic Impact: An Experimental Study Using a Pig Physical Head Model and Live Pigs</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Liu, Hai; Kang, Jianyi; Chen, Jing; Li, Guanhua; Li, Xiaoxia; Wang, Jianmin 2012-01-01 This study was conducted to characterize the intracranial pressure response to non-penetrating ballistic impact using a "scalp-skull-brain" pig physical head model and live pigs. Forty-eight ballistic tests targeting the physical head model and anesthetized pigs protected by aramid plates were conducted with standard 9 mm bullets at low (279-297 m/s), moderate (350-372 m/s), and high (409-436 m/s) velocities. Intracranial pressure responses were recorded with pressure sensors embedded in similar brain locations in the physical head model and the anesthetized pigs. Three parameters of intracranial pressure were determined from the measured data: intracranial maximum pressure (Pmax), intracranial maximum pressure impulse (PImax), and the duration of the first positive phase (PPD). The intracranial pressure waves exhibited blast-like characteristics for both the physical model and l live pigs. Of all three parameters, Pmax is most sensitive to impact velocity, with means of 126 kPa (219 kPa), 178 kPa (474 kPa), and 241 kPa (751 kPa) for the physical model (live pigs) for low, moderate, and high impact velocities, respectively. The mean PPD becomes increasingly short as the impact velocity increases, whereas PImax shows the opposite trend. Although the pressure parameters of the physical model were much lower than those of the live pigs, good correlations between the physical model and the live pigs for the three pressure parameters, especially Pmax, were found using linear regression. This investigation suggests that Pmax is a preferred parameter for predicting the severity of the brain injury resulting from behind armor blunt trauma (BABT). PMID:23055817 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24586940','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24586940">PPARγ ligands decrease hydrostatic pressure-induced platelet aggregation and proinflammatory activity.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Rao, Fang; Yang, Ren-Qiang; Chen, Xiao-Shu; Xu, Jin-Song; Fu, Hui-Min; Su, Hai; Wang, Ling 2014-01-01 Hypertension is known to be associated with platelet overactivity, but the direct effects of hydrostatic pressure on platelet function remain unclear. The present study sought to investigate whether elevated hydrostatic pressure is responsible for platelet activation and to address the potential role of peroxisome proliferator-activated receptor-γ (PPARγ). We observed that hypertensive patients had significantly higher platelet volume and rate of ADP-induced platelets aggregation compared to the controls. In vitro, Primary human platelets were cultured under standard (0 mmHg) or increased (120, 180, 240 mmHg) hydrostatic pressure for 18 h. Exposure to elevated pressure was associated with morphological changes in platelets. Platelet aggregation and PAC-1 (the active confirmation of GPIIb/IIIa) binding were increased, CD40L was translocated from cytoplasm to the surface of platelet and soluble CD40L (sCD40L) was released into the medium in response to elevated hydrostatic pressure (180 and 240 mmHg). The PPARγ activity was up-regulated as the pressure was increased from 120 mmHg to 180 mmHg. Pressure-induced platelet aggregation, PAC-1 binding, and translocation and release of CD40L were all attenuated by the PPARγ agonist Thiazolidinediones (TZDs). These results demonstrate that platelet activation and aggregation are increased by exposure to elevated pressure and that PPARγ may modulate platelet activation induced by high hydrostatic pressure. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3938478','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3938478">PPARγ Ligands Decrease Hydrostatic Pressure-Induced Platelet Aggregation and Proinflammatory Activity</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Chen, Xiao-Shu; Xu, Jin-Song; Fu, Hui-Min; Su, Hai; Wang, Ling 2014-01-01 Hypertension is known to be associated with platelet overactivity, but the direct effects of hydrostatic pressure on platelet function remain unclear. The present study sought to investigate whether elevated hydrostatic pressure is responsible for platelet activation and to address the potential role of peroxisome proliferator-activated receptor-γ (PPARγ). We observed that hypertensive patients had significantly higher platelet volume and rate of ADP-induced platelets aggregation compared to the controls. In vitro, Primary human platelets were cultured under standard (0 mmHg) or increased (120, 180, 240 mmHg) hydrostatic pressure for 18 h. Exposure to elevated pressure was associated with morphological changes in platelets. Platelet aggregation and PAC-1 (the active confirmation of GPIIb/IIIa) binding were increased, CD40L was translocated from cytoplasm to the surface of platelet and soluble CD40L (sCD40L) was released into the medium in response to elevated hydrostatic pressure (180 and 240 mmHg). The PPARγ activity was up-regulated as the pressure was increased from 120 mmHg to 180 mmHg. Pressure-induced platelet aggregation, PAC-1 binding, and translocation and release of CD40L were all attenuated by the PPARγ agonist Thiazolidinediones (TZDs). These results demonstrate that platelet activation and aggregation are increased by exposure to elevated pressure and that PPARγ may modulate platelet activation induced by high hydrostatic pressure. PMID:24586940 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22885217','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22885217">Neonatal nociception elevated baseline blood pressure and attenuated cardiovascular responsiveness to noxious stress in adult rats.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Chu, Ya-Chun; Yang, Cheryl C H; Lin, Ho-Tien; Chen, Pin-Tarng; Chang, Kuang-Yi; Yang, Shun-Chin; Kuo, Terry B J 2012-10-01 Neonatal nociception has significant long-term effects on sensory perception in adult animals. Although neonatal adverse experience affect future responsiveness to stressors is documented, little is known about the involvement of early nociceptive experiences in the susceptibility to subsequent nociceptive stress exposure during adulthood. The aim of this study is to explore the developmental change in cardiovascular regulating activity in adult rats that had been subjected to neonatal nociceptive insults. To address this question, we treated neonatal rats with an intraplantar injection of saline (control) or carrageenan at postnatal day 1. The carrageenan-treated rats exhibited generalized hypoalgesia at basal state, and localized hyperalgesia after re-nociceptive challenge induced by intraplantar injections of complete Freund's adjuvant (CFA) as adults. Then we recorded baseline cardiovascular variables and 24-h responsiveness to an injection of CFA in the free-moving adult rats with telemetric technique. The carrageenan-treated rats showed significantly higher basal blood pressures (110.3±3.16 vs. control 97.0±4.28 mmHg). In control animals, baroreceptor reflex sensitivity (BRS) decreased, sympathetic vasomotor activity increased, and parasympathetic activity was inhibited after CFA injection. Blood pressure elevation was evident (107.0±2.75 vs. pre-injection 97.0±4.28 mmHg). Comparatively, the carrageenan-treated rats showed a higher BRS (BrrLF 1.03±0.09 vs. control 0.70±0.06 ms/mmHg) and higher parasympathetic activity [0.93±0.17 vs. control 0.32±0.02 ln(ms²)] after CFA injection. The change in blood pressure is negligible (111.9±4.05 vs. pre-injection 110.3±3.16 mmHg). Our research has shown that neonatal nociception alters future pain sensation, raises basal blood pressure level, and attenuates cardiovascular responsiveness to nociceptive stress in adult rats. Copyright © 2012 ISDN. Published by Elsevier Ltd. All rights reserved. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19850065065&hterms=sleep+effects&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D70%26Ntt%3Dsleep%2Beffects','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19850065065&hterms=sleep+effects&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D70%26Ntt%3Dsleep%2Beffects">Primate body temperature and sleep responses to lower body positive pressure</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Edgar, D. M.; Fuller, C. A. 1984-01-01 Cephalic fluid shifts, induced by lower body positive pressure (LBPP) are known to influence various physiological systems (i.e., cardiovascular and renal). In earlier experiments, an apparent change in the arousal state of primates in such LBPP conditions was observed. This study was designed to examine the effects of LBPP on arousal state and body temperature level which is normally correlated with sleep. Chair-restrained male squirrel monkeys were exposed to 40 mmHg LBPP for 90-100 minutes between the daytime hours of 13:00-15:00. Each monkey was placed in a specially modified restraint chair to which they were highly trained. Deep body temperature (DBT) was collected from 10 animals. Sleep parameters were obtained from six animals chronically implanted for sleep recording. A video camera was used to observe each animal's apparent state of arousal. LBPP resulted in an approximate 0.9 C decrease in DBT. During video observation, some animals appeared drowsy during LBPP; however, sleep recording revealed no significant changes in the state of arousal. Thus, LBPP is capable of inducing a mild hyperthermia. Further, the mechanisms underlying the observed lowering of body temperature appear to be independent of arousal state. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018ExFl...59..108S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018ExFl...59..108S">Experimental analysis of transonic buffet on a 3D swept wing using fast-response pressure-sensitive paint</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Sugioka, Yosuke; Koike, Shunsuke; Nakakita, Kazuyuki; Numata, Daiju; Nonomura, Taku; Asai, Keisuke 2018-06-01 Transonic buffeting phenomena on a three-dimensional swept wing were experimentally analyzed using a fast-response pressure-sensitive paint (PSP). The experiment was conducted using an 80%-scaled NASA Common Research Model in the Japan Aerospace Exploration Agency (JAXA) 2 m × 2 m Transonic Wind Tunnel at a Mach number of 0.85 and a chord Reynolds number of 1.54 × 106. The angle of attack was varied between 2.82° and 6.52°. The calculation of root-mean-square (RMS) pressure fluctuations and spectral analysis were performed on measured unsteady PSP images to analyze the phenomena under off-design buffet conditions. We found that two types of shock behavior exist. The first is a shock oscillation characterized by the presence of "buffet cells" formed at a bump Strouhal number St of 0.3-0.5, which is observed under all off-design conditions. This phenomenon arises at the mid-span wing and is propagated spanwise from inboard to outboard. The other is a large spatial amplitude shock oscillation characterized by low-frequency broadband components at St < 0.1, which appears at higher angles of attack ( α ≥ 6.0°) and behaves more like two-dimensional buffet. The transition between these two shock behaviors correlates well with the rapid increase of the wing-root strain fluctuation RMS. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27432864','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27432864">Renal Nerve Stimulation-Induced Blood Pressure Changes Predict Ambulatory Blood Pressure Response After Renal Denervation.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> de Jong, Mark R; Adiyaman, Ahmet; Gal, Pim; Smit, Jaap Jan J; Delnoy, Peter Paul H M; Heeg, Jan-Evert; van Hasselt, Boudewijn A A M; Lau, Elizabeth O Y; Persu, Alexandre; Staessen, Jan A; Ramdat Misier, Anand R; Steinberg, Jonathan S; Elvan, Arif 2016-09-01 Blood pressure (BP) response to renal denervation (RDN) is highly variable and its effectiveness debated. A procedural end point for RDN may improve consistency of response. The objective of the current analysis was to look for the association between renal nerve stimulation (RNS)-induced BP increase before and after RDN and changes in ambulatory BP monitoring (ABPM) after RDN. Fourteen patients with drug-resistant hypertension referred for RDN were included. RNS was performed under general anesthesia at 4 sites in the right and left renal arteries, both before and immediately after RDN. RNS-induced BP changes were monitored and correlated to changes in ambulatory BP at a follow-up of 3 to 6 months after RDN. RNS resulted in a systolic BP increase of 50±27 mm Hg before RDN and systolic BP increase of 13±16 mm Hg after RDN (P<0.001). Average systolic ABPM was 153±11 mm Hg before RDN and decreased to 137±10 mm Hg at 3- to 6-month follow-up (P=0.003). Changes in RNS-induced BP increase before versus immediately after RDN and changes in ABPM before versus 3 to 6 months after RDN were correlated, both for systolic BP (R=0.77, P=0.001) and diastolic BP (R=0.79, P=0.001). RNS-induced maximum BP increase before RDN had a correlation of R=0.61 (P=0.020) for systolic and R=0.71 (P=0.004) for diastolic ABPM changes. RNS-induced BP changes before versus after RDN were correlated with changes in 24-hour ABPM 3 to 6 months after RDN. RNS should be tested as an acute end point to assess the efficacy of RDN and predict BP response to RDN. © 2016 American Heart Association, Inc. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015CliPa..11.1027B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015CliPa..11.1027B">A collection of sub-daily pressure and temperature observations for the early instrumental period with a focus on the "year without a summer" 1816</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Brugnara, Y.; Auchmann, R.; Brönnimann, S.; Allan, R. J.; Auer, I.; Barriendos, M.; Bergström, H.; Bhend, J.; Brázdil, R.; Compo, G. P.; Cornes, R. C.; Dominguez-Castro, F.; van Engelen, A. F. V.; Filipiak, J.; Holopainen, J.; Jourdain, S.; Kunz, M.; Luterbacher, J.; Maugeri, M.; Mercalli, L.; Moberg, A.; Mock, C. J.; Pichard, G.; Řezníčková, L.; van der Schrier, G.; Slonosky, V.; Ustrnul, Z.; Valente, M. A.; Wypych, A.; Yin, X. 2015-08-01 The eruption of Mount Tambora (Indonesia) in April 1815 is the largest documented volcanic eruption in history. It is associated with a large global cooling during the following year, felt particularly in parts of Europe and North America, where the year 1816 became known as the "year without a summer". This paper describes an effort made to collect surface meteorological observations from the early instrumental period, with a focus on the years of and immediately following the eruption (1815-1817). Although the collection aimed in particular at pressure observations, correspondent temperature observations were also recovered. Some of the series had already been described in the literature, but a large part of the data, recently digitised from original weather diaries and contemporary magazines and newspapers, is presented here for the first time. The collection puts together more than 50 sub-daily series from land observatories in Europe and North America and from ships in the tropics. The pressure observations have been corrected for temperature and gravity and reduced to mean sea level. Moreover, an additional statistical correction was applied to take into account common error sources in mercury barometers. To assess the reliability of the corrected data set, the variance in the pressure observations is compared with modern climatologies, and single observations are used for synoptic analyses of three case studies in Europe. All raw observations will be made available to the scientific community in the International Surface Pressure Databank. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/4091942','DOE-PATENT-XML'); return false;" href="https://www.osti.gov/biblio/4091942">PRESSURE SYSTEM CONTROL</a> <a target="_blank" href="http://www.osti.gov/doepatents">DOEpatents</a> Esselman, W.H.; Kaplan, G.M. 1961-06-20 The control of pressure in pressurized liquid systems, especially a pressurized liquid reactor system, may be achieved by providing a bias circuit or loop across a closed loop having a flow restriction means in the form of an orifice, a storage tank, and a pump connected in series. The subject invention is advantageously utilized where control of a reactor can be achieved by response to the temperature and pressure of the primary cooling system. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20929695','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20929695">The influence of α-adducin gene polymorphism on response of blood pressure to exercise in patients with hypertension.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Alioğlu, Emin; Ercan, Ertuğrul; Tengiz, Istemihan; Türk, Uğur Onsel; Ergün, Metin; Akgöz, Semra; Işlegen, Cetin; Berdeli, Afig 2010-10-01 Clinical studies have indicated that an excessive response of blood pressure (BP) to exercise predicts risk of cardiovascular mortality. Although the mechanism responsible for the excessive BP response to exercise has not been revealed, there are some plausible mechanisms linking with underlying structural abnormalities in the cardiovascular system. Carriers of the Trp460 allele of the α-adducin Gly460Trp polymorphism have an increased risk of hypertension. The aim of the present study was to examine the influence of α-adducin gene polymorphism on response of BP to exercise in patients with hypertension. The cross-sectional observational study consisted of 49 hypertensive patients (29 women and 20 men; mean age, 53.1±8.8 years). All participants underwent a multistage exercise treadmill test according to the Bruce protocol. Arterial BPs were compared at rest, peak exercise and end of the recovery phase. Patients were classified according to their α-adducin gene polymorphisms; Gly460Gly homozygotes - Group 1 (n=28) and Trp460Trp homozygotes and Gly460Trp heterozygotes - Group 2 (n=21). Statistical analysis was performed using Chi-square, unpaired t, Mann-Whitney U and ANCOVA tests. Mean exercise duration and mean exercise capacity in metabolic equivalents were not different between Group 1 and 2. The major finding of the study was that systolic BP responses at peak exercise and recovery period (3. min) were significantly higher (p=0.036) in hypertensive patients carrying at least one Trp460 allele of the α-adducin gene. Our results suggest that genetic variants that alter renal function and/or vasoreactivity are logical candidates to explain some of the individual variability in the BP response to exercise. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20040089312&hterms=hook+effect&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Dhook%2Beffect','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20040089312&hterms=hook+effect&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Dhook%2Beffect">Comparison of electric and growth responses to excision in cucumber and pea seedlings. II. Long-distance effects are caused by the release of xylem pressure</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Stahlberg, R.; Cosgrove, D. J. 1995-01-01 Excision of a growing stem causes local wound responses, such as membrane depolarization and growth inhibition, as well as effects at larger distances from the cut. In this study, cucumber hypocotyls were excised 100 mm below the hook, so that the growing region was beyond the reach of the wound-induced depolarization (up to 40 mm). Even at such a distance, the cut still caused a considerable and rapid drop in the hypocotyl growth rate. This growth response is not a direct wound response because it does not result from the cut-induced depolarization and because it can be simulated by root pressure manipulation (using a pressure chamber). The results indicate that the growth response resulted from the rapid release of the xylem pressure upon excision. To test this conclusion we measured the xylem pressure by connecting a pressure probe to the cut surface of the stem. Xylem pressure (Px) was found to be +10 to +40 kPa in cucumber hypocotyls and -5 to -10 kPa or lower in pea epicotyls. Excision of the cucumber hypocotyl base led to a rapid drop in Px to negative values, whereas excision in pea led to a rapid rise in Px to ambient (zero) pressure. These fast and opposite Px changes parallel the excision-induced changes in growth rate (GR): a decrease in cucumber and a rise in pea. The sign of the endogenous xylem pressure also determined whether excision induced a propagating depolarization in the form of a slow wave potential (SWP). Under normal circumstances pea seedlings generated an SWP upon excision whereas cucumber seedlings failed to do so. When the Px in cucumber hypocotyls was experimentally inverted to negative values by incubating the cumber roots in solutions of NaCN or n-ethylmaleimide, excision caused a propagating depolarization (SWP). The experiment shows that only hydraulic signals in the form of positive Px steps are converted into propagating electric SWP signals. These propagating depolarizations might be causally linked to systemic 'wound </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16362400','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16362400">Effects of a brisk walk on blood pressure responses to the Stroop, a speech task and a smoking cue among temporarily abstinent smokers.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Taylor, Adrian; Katomeri, Magdalena 2006-01-01 A review and meta-analysis by Hamer et al. (2006) showed that a single session of exercise can attenuate post-exercise blood pressure (BP) responses to stress, but no studies examined the effects among smokers or with brisk walking. Healthy volunteers (n=60), averaging 28 years of age and smoking 15 cigarettes daily, abstained from smoking for 2 h before being randomly assigned to a 15-min brisk semi-self-paced walk or passive control condition. Subject characteristics, typical smoking cue-elicited cravings and BP were assessed at baseline. After each condition, BP was assessed before and after three psycho-social stressors were carried out: (1) computerised Stroop word-colour interference task, (2) speech task and (3) only handling a lit cigarette. A two-way mixed ANCOVA (controlling for baseline) revealed a significant overall interaction effect for time by condition for both systolic blood pressure (SBP) and diastolic blood pressure (DBP). Univariate ANCOVAs (to compare between-groups post-stressor BP, controlling for pre-stressor BP) revealed that exercise attenuated systolic BP and diastolic BP responses to the Stroop and speech tasks and SBP to the lit cigarette equivalent to an attenuated SBP and DBP of up to 3.8 mmHg. Post-exercise attenuation effects were moderated by resting blood pressure and self-reported smoking cue-elicited craving. Effects were strongest among those with higher blood pressure and smokers who reported typically stronger cravings when faced with smoking cues. Blood pressure responses to the lit cigarette were not associated with responses to the Stroop and speech task. A self-paced 15-min walk can reduce smokers' SBP and DBP responses to stress, of a magnitude similar on average to non-smokers. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/21044889-experimental-investigation-unsteady-response-premixed-flame-fronts-acoustic-pressure-waves','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/21044889-experimental-investigation-unsteady-response-premixed-flame-fronts-acoustic-pressure-waves">Experimental investigation of the unsteady response of premixed flame fronts to acoustic pressure waves</a> <a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a> Wangher, Athena; Searby, Geoff; Quinard, Joel Using OH{sup *} chemiluminescence, we measure the experimental unsteady response of a 1-D premixed flame to an acoustic pressure wave for a range of frequencies below and above the inverse of the flame transit time. We find that the response is positive and, at low frequency, the order of magnitude is comparable with existing theoretical analyses. However, if it is assumed that the chemiluminescence is proportional to the mass consumption rate, despite some uncertainty in the interpretation of the chemiluminescence signal we find that the frequency dependence of the measured response is not compatible with the predictions of the standardmore » flame model for one-step Arrhenius kinetics. A better, but not perfect, correlation is obtained for the heat release rate. We conclude that the standard model does not provide an adequate description of the unsteady response of real flames and that it is necessary to investigate more realistic chemical models. (author)« less </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27195451','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27195451">Worse cardiac remodeling in response to pressure overload in type 2 diabetes mellitus.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Gonçalves, N; Gomes-Ferreira, C; Moura, C; Roncon-Albuquerque, R; Leite-Moreira, A F; Falcão-Pires, I 2016-08-15 Diabetic cardiomyopathy is characterized by cardiac structural and functional abnormalities. Additionally, chronic pressure overload conditions are highly prevalent amongst diabetic population and this association leads to a more severe myocardial impairment. The differences in myocardial pathophysiology between type 1 and type 2 diabetes mellitus (DM) still remain to be clarified. Thus, we aimed to investigate biventricular structural and functional changes promoted by the two types of DM and the impact of concomitant chronic pressure overload. Wistar rats were injected with streptozotocin (Type 1 DM, T1DM) or fed with a hypercaloric diet (Type 2 DM, T2DM). Pressure overload was imposed in DM animals by aortic constriction and after 5weeks of DM the cardiac function and structure were evaluated. Both types of DM promoted hypertrophy, increased fibrosis and advanced glycation end-products deposition, in the two ventricles. Interestingly, the induced myocardial alterations were distinct. While T1DM stimulated a pronounced hypertrophy and extracellular matrix remodeling, T2DM induced functional impairment. The negative impact of the association of DM with aortic constriction was more pronounced in T2DM, promoting impaired function and increased stiffness, particularly in the right ventricle. Our study demonstrated that the two types of diabetes induce distinct cardiac alterations per se or when combined with chronic pressure overload. T1DM promoted a more extensive remodeling in cardiac structure while T2DM significantly impaired ventricular function. The impact of pressure overload was more notorious in T2DM as observed by worse myocardial remodeling, suggesting a higher susceptibility to the deleterious effects of chronic pressure overload, namely hypertension, among this diabetic population. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017ApJ...844..156R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017ApJ...844..156R">From Neutron Star Observables to the Equation of State. II. Bayesian Inference of Equation of State Pressures</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Raithel, Carolyn A.; Özel, Feryal; Psaltis, Dimitrios 2017-08-01 One of the key goals of observing neutron stars is to infer the equation of state (EoS) of the cold, ultradense matter in their interiors. Here, we present a Bayesian statistical method of inferring the pressures at five fixed densities, from a sample of mock neutron star masses and radii. We show that while five polytropic segments are needed for maximum flexibility in the absence of any prior knowledge of the EoS, regularizers are also necessary to ensure that simple underlying EoS are not over-parameterized. For ideal data with small measurement uncertainties, we show that the pressure at roughly twice the nuclear saturation density, {ρ }{sat}, can be inferred to within 0.3 dex for many realizations of potential sources of uncertainties. The pressures of more complicated EoS with significant phase transitions can also be inferred to within ˜30%. We also find that marginalizing the multi-dimensional parameter space of pressure to infer a mass-radius relation can lead to biases of nearly 1 km in radius, toward larger radii. Using the full, five-dimensional posterior likelihoods avoids this bias. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/11568682','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/11568682">Elevation of internal auditory canal pressure by vestibular schwannomas.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Badie, B; Pyle, G M; Nguyen, P H; Hadar, E J 2001-09-01 The exact mechanism of hearing loss, the most common presenting symptom in patients with vestibular schwannomas, remains unclear. To test whether increased pressure in the internal auditory canal from tumor growth is responsible for this clinical finding, the intracanalicular pressure in patients harboring these tumors was measured. Prospective study. Tertiary referral hospital. Fifteen consecutive patients undergoing a retrosigmoid approach for resection of vestibular schwannomas were included in the study. The intracanalicular pressure in every patient was measured by introducing a pressure microsensor into the internal auditory canal. The pressure readings, which were performed before tumor resection, were then correlated with tumor size and respective preoperative hearing status. Placement of the pressure monitor into the internal auditory canal revealed a biphasic waveform in every patient. Whereas the mean intracanalicular pressure was 20 mm Hg, there was significant variability among patients (range, 1-45 mm Hg). The intracanalicular pressure directly correlated with the amount of tumor in the internal auditory canal (r > 0.63, p < 0.012) but not with the total tumor size (r </= 0.40, p > 0.075). Furthermore, eight patients with class A preoperative hearing (American Academy of Otolaryngology-Head and Neck Surgery classification) had lower intracanalicular pressures than did five patients with class B hearing (16 +/- 5 vs. 28 +/- 4). Although this observation suggested an inverse correlation between the intracanalicular pressure and hearing function, the difference between the two groups was not statistically significant (p = 0.14). Pressure on the cochlear nerve as a result of tumor growth in the internal auditory canal may be responsible for hearing loss in patients with vestibular schwannomas. Modification of surgical techniques to address the elevated intracanalicular pressure may be beneficial in improving hearing preservation in these patients. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19910035037&hterms=sensors+pressure&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D80%26Ntt%3Dsensors%2Bpressure','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19910035037&hterms=sensors+pressure&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D80%26Ntt%3Dsensors%2Bpressure">A temperature and pressure controlled calibration system for pressure sensors</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Chapman, John J.; Kahng, Seun K. 1989-01-01 A data acquisition and experiment control system capable of simulating temperatures from -184 to +220 C and pressures either absolute or differential from 0 to 344.74 kPa is developed to characterize silicon pressure sensor response to temperature and pressure. System software is described that includes sensor data acquisition, algorithms for numerically derived thermal offset and sensitivity correction, and operation of the environmental chamber and pressure standard. This system is shown to be capable of computer interfaced cryogenic testing to within 1 C and 34.47 Pa of single channel or multiplexed arrays of silicon pressure sensors. </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active">21</li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_22" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active">22</li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="421"> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27936961','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27936961">Exaggerated exercise blood pressure response in middle-aged men as a predictor of future blood pressure: a 10-year follow-up.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Ito, Katsuyuki; Iwane, Masataka; Miyai, Nobuyuki; Uchikawa, Yukiko; Mugitani, Koichi; Mohara, Osamu; Shiba, Mitsuru; Arita, Mikio The prognostic value of an exaggerated exercise systolic blood pressure response (EESBPR) remains controversial. This study was designed to assess whether an EESBPR is associated with the predictor of future blood pressure. From an initial population of 1,534 male-subjects with normal BP or no medication who underwent ergometric exercise, 733 subjects (mean age: 41 years old) at baseline to follow-up BP after an average of 10 years were selected. A 12-min exercise tolerance test with three phases of estimated load from predictive maximum oxygen intake was performed at baseline, and exercise BP was measured. Exercise BP response was classified by three group: Low group (G) (exercise SBP < 180 mmHg), Middle G (exercise BP:180-199 mmHg), High G (exercise BP:200 mmHg ≦). BP after 10 years in Low G was 123 ± 12/79 ± 7 mmHg, in Middle G:127 ± 13/81 ± 8 mmHg, in High G :134 ± 15/84 ± 10 mmHg. Compared with in Low G, BP after 10 years in High G significantly increased (p < 0.05). Multiple regression analysis was carried out to clarify the relationship of exercise SBP at baseline to BP after 10 years. In multivariate-adjusted models, the relationship of SBP at follow-up was stronger to exercise SBP (β = 0.271, P < 0.001) than to resting SBP (β = 0.148, P < 0.001). Maximum oxygen intake (β = -0.193, P = 0.003) and resting SBP correlated with SBP after 10 years. In middle-aged men, exercise SBP would be a stronger predictor of future SBP, DBP rather than BP at rest. In optimal of classification of BP (SBP < 120 mmHg), exercise BP response was clearly associated with BP after 10 years. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://pubs.er.usgs.gov/publication/70018153','USGSPUBS'); return false;" href="https://pubs.er.usgs.gov/publication/70018153">Aquifer Response to Record Low Barometric Pressures in the Southeastern United States</a> <a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a> Landmeyer, J.E. 1996-01-01 A late-winter cyclone classified as one of the most intense of the 20th century moved across the Southeastern states of Georgia and South Carolina and onto the Northeast during March 12-14, 1993. Record low barometric pressures were recorded in Augusta, Georgia (28.93 inches of mercury) and Columbia, South Carolina (28.63 inches of mercury) on March 13,1993, and pressures returned to normal values (near 3D inches of mercury) within one day following these record lows. This relatively unusual event provided an opportunity to examine the attendant water-level response in continuously monitored ground-water wells in regional Atlantic Coastal Plain, Piedmont, and Blue Ridge aquifers in the Southeast. Water levels in all wells examined responded inversely to the short duration, extreme drop in barometric pressure. Barometric efficiencies (??ground-water level/??barometric-pressure level) calculated were dependent on depth to screened- or open-interval midpoint (highest correlation coefficient, r2 = 0.89) and, to a lesser extent, total thickness of confining material above the aquifer tapped (highest r2 = 0.65). Wells in crystalline-rock aquifers had a correlation with depth to open-interval midpoint (r2 = 0.89) similar to the sedimentary aquifers examined. The magnitude of barometric efficiency was also strongly related to a well's increased distance from aquifer outcrop areas in the Cretaceous aquifers in South Carolina (r2 = 0.95) and the upper Brunswick aquifer in Georgia (r2 = 0.90), because these aquifers are more deeply buried toward the coast. This relation between barometric efficiency, well depth, and extent of confinement suggests that barometric efficiency determinations can provide useful information to hydrologists concerned with examining an aquifer's degree of confinement and corresponding isolation from land surface, particularly when the aquifer is used as a source for public supply. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27054270','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27054270">Highly Sensitive and Patchable Pressure Sensors Mimicking Ion-Channel-Engaged Sensory Organs.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Chun, Kyoung-Yong; Son, Young Jun; Han, Chang-Soo 2016-04-26 Biological ion channels have led to much inspiration because of their unique and exquisite operational functions in living cells. Specifically, their extreme and dynamic sensing abilities can be realized by the combination of receptors and nanopores coupled together to construct an ion channel system. In the current study, we demonstrated that artificial ion channel pressure sensors inspired by nature for detecting pressure are highly sensitive and patchable. Our ion channel pressure sensors basically consisted of receptors and nanopore membranes, enabling dynamic current responses to external forces for multiple applications. The ion channel pressure sensors had a sensitivity of ∼5.6 kPa(-1) and a response time of ∼12 ms at a frequency of 1 Hz. The power consumption was recorded as less than a few μW. Moreover, a reliability test showed stability over 10 000 loading-unloading cycles. Additionally, linear regression was performed in terms of temperature, which showed no significant variations, and there were no significant current variations with humidity. The patchable ion channel pressure sensors were then used to detect blood pressure/pulse in humans, and different signals were clearly observed for each person. Additionally, modified ion channel pressure sensors detected complex motions including pressing and folding in a high-pressure range (10-20 kPa). </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20020022192&hterms=balance+sheet&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D60%26Ntt%3Dbalance%2Bsheet','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20020022192&hterms=balance+sheet&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D60%26Ntt%3Dbalance%2Bsheet">Relation Between Pressure Balance Structures and Polar Plumes from Ulysses High Latitude Observations</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Yamauchi, Y.; Suess, Steven T.; Sakurai, T.; Whitaker, Ann F. (Technical Monitor) 2001-01-01 Ulysses observations have shown that pressure balance structures (PBSs) are a common feature in high-latitude, fast solar wind near solar minimum. Previous studies of Ulysses/SWOOPS plasma data suggest these PBSs may be remnants of coronal polar plumes. Here we find support for this suggestion in an analysis of PBS magnetic structure. We used Ulysses magnetometer data and applied a minimum variance analysis to discontinuities. We found that PBSs preferentially contain tangential discontinuities, as opposed to rotational discontinuities and to non-PBS regions in the solar wind. This suggests that PBSs contain structures like current sheets or plasmoids that may be associated with network activity at the base of plumes. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4162548','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4162548">Transcriptomics Reveal Several Gene Expression Patterns in the Piezophile Desulfovibrio hydrothermalis in Response to Hydrostatic Pressure</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Amrani, Amira; Bergon, Aurélie; Holota, Hélène; Tamburini, Christian; Garel, Marc; Ollivier, Bernard; Imbert, Jean; Dolla, Alain; Pradel, Nathalie 2014-01-01 RNA-seq was used to study the response of Desulfovibrio hydrothermalis, isolated from a deep-sea hydrothermal chimney on the East-Pacific Rise at a depth of 2,600 m, to various hydrostatic pressure growth conditions. The transcriptomic datasets obtained after growth at 26, 10 and 0.1 MPa identified only 65 differentially expressed genes that were distributed among four main categories: aromatic amino acid and glutamate metabolisms, energy metabolism, signal transduction, and unknown function. The gene expression patterns suggest that D. hydrothermalis uses at least three different adaptation mechanisms, according to a hydrostatic pressure threshold (HPt) that was estimated to be above 10 MPa. Both glutamate and energy metabolism were found to play crucial roles in these mechanisms. Quantitation of the glutamate levels in cells revealed its accumulation at high hydrostatic pressure, suggesting its role as a piezolyte. ATP measurements showed that the energy metabolism of this bacterium is optimized for deep-sea life conditions. This study provides new insights into the molecular mechanisms linked to hydrostatic pressure adaptation in sulfate-reducing bacteria. PMID:25215865 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27568389','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27568389">Effect of deep pressure input on parasympathetic system in patients with wisdom tooth surgery.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Chen, Hsin-Yung; Yang, Hsiang; Meng, Ling-Fu; Chan, Pei-Ying Sarah; Yang, Chia-Yen; Chen, Hsin-Ming 2016-10-01 Deep pressure input is used to normalize physiological arousal due to stress. Wisdom tooth surgery is an invasive dental procedure with high stress levels, and an alleviation strategy is rarely applied during extraction. In this study, we investigated the effects of deep pressure input on autonomic responses to wisdom tooth extraction in healthy adults. A randomized, controlled, crossover design was used for dental patients who were allocated to experimental and control groups that received treatment with or without deep pressure input, respectively. Autonomic indicators, namely the heart rate (HR), percentage of low-frequency (LF) HR variability (LF-HRV), percentage of high-frequency (HF) HRV (HF-HRV), and LF/HF HRV ratio (LF/HF-HRV), were assessed at the baseline, during wisdom tooth extraction, and in the posttreatment phase. Wisdom tooth extraction caused significant autonomic parameter changes in both groups; however, differential response patterns were observed between the two groups. In particular, deep pressure input in the experimental group was associated with higher HF-HRV and lower LF/HF-HRV during extraction compared with those in the control group. LF/HF-HRV measurement revealed balanced sympathovagal activation in response to deep pressure application. The results suggest that the application of deep pressure alters the response of HF-HRV and facilitates maintaining sympathovagal balance during wisdom tooth extraction. Copyright © 2016. Published by Elsevier B.V. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017JAP...122v4105C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017JAP...122v4105C">Enhanced performance of ferroelectric materials under hydrostatic pressure</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Chauhan, Aditya; Patel, Satyanarayan; Wang, Shuai; Novak, Nikola; Xu, Bai-Xiang; Lv, Peng; Vaish, Rahul; Lynch, Christopher S. 2017-12-01 Mechanical confinement or restricted degrees of freedom have been explored for its potential to enhance the performance of ferroelectric devices. It presents an easy and reversible method to tune the response for specific applications. However, such studies have been mainly limited to uni- or bi-axial stress. This study investigates the effect of hydrostatic pressure on the ferroelectric behavior of bulk polycrystalline Pb0.99Nb0.02(Zr0.95Ti0.05)0.98O3. Polarization versus electric field hysteresis plots were generated as a function of hydrostatic pressure for a range of operating temperatures (298-398 K). The application of hydrostatic pressure was observed to induce anti-ferroelectric like double hysteresis loops. This in turn enhances the piezoelectric, energy storage, energy harvesting, and electrocaloric effects. The hydrostatic piezoelectric coefficient (dh) was increased from 50 pCN-1 (0 MPa) to ˜900 pC N-1 (265 MPa) and ˜3200 pCN-1 (330 MPa) at 298 K. Energy storage density was observed to improve by more than 4 times under pressure, in the whole temperature range. The relative change in entropy was also observed to shift from ˜0 to 4.8 J kg-1 K-1 under an applied pressure of 325 MPa. This behavior can be attributed to the evolution of pinched hysteresis loops that have been explained using a phenomenological model. All values represent an improvement of several hundred percent compared to unbiased performance, indicating the potential benefits of the proposed methodology. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/10977596','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/10977596">Modelling the interaction among several mechanisms in the short-term arterial pressure control.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Ursino, M 2000-01-01 A Mathematical model of the short-term arterial pressure control in humans is presented. It includes a six-compartment description of the vascular system, an elastance variable model of the pulsating heart, two groups of baroreceptors (high-pressure or sinoaortic baroreceptors and low-pressure or cardiopulmonary baroreceptors), the efferent activity in the sympathetic nerves and in the vagus, and the response of four distinct effectors (heart period, systemic peripheral resistance, systemic venous unstressed volume and heart contractility). Several experimental results reported in the physiological literature can be reproduced with the model quite well. The examples presented in this work include the effect of combined sympathetic and vagal stimulation on heart rate, the baroreflex response to mild and severe acute haemorrhages, and the baroreflex response to ventricular pacing at different rates performed during atrioventricular block. The results suggest that: i) The sympathetic nerves and the vagus interact linearly in regulating heart period. The apparent negative interaction observed experimentally can be ascribed merely to the hyperbolic relationship which links heart rate to heart period. ii) The cardiopulmonary baroafferents play a significant role in the control of systemic arterial pressure during mild haemorrhages (lower than 3-4% of the overall blood volume). In this range, they may allow arterial pressure to be maintained at its normal level without the intervention of the sinoaortic baroreceptors. In contrast, the sinoaortic baroreceptors become the major responsible of the observed cardiovascular adjustments during more severe haemorrhages, when the role of cardiopulmonary baroreceptors becomes progressively exhausted. iii) The stability margin of the closed-loop system is quite low. Increasing the static gain of the baroreceptors or reducing the rate-dependent component may result in self-sustained oscillations similar to Mayer waves. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018JGRD..123.3830R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018JGRD..123.3830R">Observed Responses of Mesospheric Water Vapor to Solar Cycle and Dynamical Forcings</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Remsberg, Ellis; Damadeo, Robert; Natarajan, Murali; Bhatt, Praful 2018-04-01 This study focuses on responses of mesospheric water vapor (H2O) to the solar cycle flux at Lyman-α wavelength and to dynamical forcings according to the multivariate El-Nino/Southern Oscillation (ENSO) index. The zonal-averaged responses are for latitudes from 60°S to 60°N and pressure-altitudes from 0.01 to 1.0 hPa, as obtained from multiple linear regression analyses of time series of H2O from the Halogen Occultation Experiment for July 1992 to November 2005. The results compare very well with those from a separate simultaneous temporal and spatial (STS) method that also confirms that there are no significant sampling biases affecting both sets of results. Distributions of the seasonal amplitudes for temperature and H2O are in accord with the seasonal net circulation. In general, the responses of H2O to ENSO are anticorrelated with those of temperature. H2O responses to multivariate ENSO index are negative in the upper mesosphere and largest in the Northern Hemisphere; responses in the lower mesosphere are more symmetric with latitude. H2O responses to the Lyman-α flux (Lya) vary from strong negative values in the uppermost mesosphere to very weak, positive values in the tropical lowermost mesosphere. However, the effects of those H2O responses to the solar activity extend to the rest of the mesosphere via dynamical processes. Profiles of the responses to ENSO and Lya also agree reasonably with published results for H2O at the low latitudes from the Microwave Limb Sounder. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29377715','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29377715">Fitness Level Modulates Intraocular Pressure Responses to Strength Exercises.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Vera, Jesús; Jiménez, Raimundo; Redondo, Beatríz; Cárdenas, David; García-Ramos, Amador 2018-06-01 Purpose/Aim: The execution of strength exercises has demonstrated to increase the intraocular pressure (IOP) levels, and it may have a negative impact on the ocular health. We aimed to explore the influence of fitness level on the acute IOP response to strength exercises performed under different loading conditions, as well as to test whether the IOP responses differ between the bench press and jump squat when performed against the same relative loads. Forty military personnel males were divided in two subgroups (20 high-fit and 20 low-fit) based on their relative to body mass one-repetition maximum (1-RM). Participants performed an incremental loading test in the bench press and jump squat exercises, and IOP was assessed before and after each repetition by rebound tonometry. IOP increased immediately after executing both exercises (p < 0.01 in both cases), being the magnitude of the IOP increment positively and linearly associated with the increment of the load in both groups (i.e., high-fit and low-fit) and in both exercises (R 2 range: 0.81-1.00). Higher fitness level attenuated the IOP rise produced by both exercises (p < 0.01 in both cases). The bench press induced higher IOP increments than the jump squat for both groups at relative loads of ~50%1-RM and ~60%1-RM (p < 0.01 in all cases). These data indicate that IOP increases as a consequence of performing strength exercises, being the increment accentuated with the increase of the load and in the bench press compared to the jump squat exercise. Of special importance would be that the IOP responses were significantly reduced in high-fit individuals. These findings should be addressed in glaucoma patients. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/EJ941719.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/EJ941719.pdf">Reducing Stimulus Overselectivity through an Increased Observing-Response Requirement</a> <a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a> Doughty, Adam H.; Hopkins, Michelle N. 2011-01-01 An adult with autism and a mild intellectual disability participated in a 0-s delayed matching-to-sample task. In each trial, two sample stimuli were presented together until the participant completed an observing-response requirement consisting of 1 or 10 mouse clicks in the baseline and experimental phases, respectively. One of the two sample… </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28383434','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28383434">Low-pressure capnoperitoneum reduces stress responses during pediatric laparoscopic high ligation of indirect inguinal hernia sac: A randomized controlled study.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Niu, Xiaoguang; Song, Xubin; Su, Aiping; Zhao, Shanshan; Li, Qinghao 2017-04-01 We aimed to evaluate the effect of different capnoperitoneum pressures on stress responses in pediatric laparoscopic inguinal hernia repair. In this prospective randomized controlled study, 68 children with indirect inguinal hernia who underwent high ligation of hernia sac were randomly divided into 3 groups: high-pressure group (12 mm Hg, HP group, n = 26); low-pressure group (8 mm Hg, LP group, n = 20); open operation group (OP group, n = 22). Heart rate (HR), blood pressure, and end-tidal CO2 (PetCO2) were recorded, as well as the levels of adrenocorticotropic hormone (ACTH) and cortisol (COR) were measured by ELISAs before operation, during operation, and after operation, respectively. After establishing capnoperitoneum, HR, blood pressure, and PetCO2 were significantly increased in the HP group compared with the OP and LP groups (P < 0.05). Comparing the intraoperatively measured ACTH and COR concentrations of the HP group to the LP group, we noted higher values in the first (P < 0.05). There was no significant difference in the postoperative concentrations of ACTH and COR among the HP, LP, and OP groups. Laparoscopic surgery under LP capnoperitoneum or open operation may reduce stress responses and are superior to HP capnoperitoneum. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016AGUFM.S44C..05K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016AGUFM.S44C..05K">Using regional pore-fluid pressure response following the 3 Sep 2016 Mw5.8 Pawnee, Oklahoma earthquake to constrain far-field seismicity rate forecasts</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Kroll, K.; Murray, K. E.; Cochran, E. S. 2016-12-01 The 3 Sep 2016 Mw5.8 Pawnee, Oklahoma earthquake was the largest event to occur in recorded history of the state. Widespread shaking from the event was felt in seven central U.S. states and caused damage as far away as Oklahoma City ( 115 km SSW). The Pawnee earthquake occurred soon after the deployment of a subsurface pore-fluid pressure monitoring network in Aug 2016. Eight pressure transducers were installed downhole in inactive saltwater disposal wells that were completed in the basal sedimentary zone (the Arbuckle Group). The transducers are located in Alfalfa, Grant, and Payne Counties at distances of 48 to 140 km from the Pawnee earthquake. We observed coseismic fluid pressure changes in all monitoring wells, indicating a large-scale poroelastic response in the Arbuckle. Two wells in Payne County lie in a zone of volumetric compression 48-52 km SSE of the rupture and experienced a co-seismic rise in fluid pressures that we conclude was related to poroelastic rebound of the Arbuckle reservoir. We compare measurements of the pore-fluid pressure change to estimated values given by the product of the volumetric strain, a Skempton's coefficient of 0.33, and a Bulk modulus of 25 GPa for fractured granitic basement rocks. We explore the possibility that the small increase in pore-fluid pressure may increase the rate of seismicity in regions outside of the mainshock region. We test this hypothesis by supplementing the Oklahoma Geological Survey earthquake catalog by semi-automated detection smaller magnitude (<2.6 M) earthquakes on seismic stations that are located in the vicinity of the wells. Using the events that occur in the week before the mainshock (27 Aug to 3 Sep 2016) as the background seismicity rate and the estimated pore-fluid pressure increase, we use a rate-state model to predict the seismicity rate change in the week following the event. We then compare the model predictions to the observed seismicity in the week following the Pawnee earthquake </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5785915','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5785915">Race and sex differences in cardiovascular α-adrenergic and β-adrenergic receptor responsiveness in men and women with high blood pressure</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Sherwood, Andrew; Hill, LaBarron K.; Blumenthal, James A.; Johnson, Kristy S.; Hinderliter, Alan L. 2018-01-01 Objective Hypertension is associated with unfavorable changes in adrenergic receptor responsiveness, but the relationship of race and sex to adrenergic receptor responsiveness in the development of cardiovascular disease is unclear. This study examined α-adrenergic and β-adrenergic receptor responsiveness in African-American and white men and women with untreated high blood pressure (BP) (HBP) and with normal BP. Methods and results The study sample comprised 161 African-American and white men and women in the age range 25–45 years. Isoproterenol, a nonselective β-adrenergic receptor agonist, was administered intravenously to determine the bolus dose required to increase heart rate by 25 bpm, an index of β-adrenergic receptor responsiveness. Similarly, phenylephrine, an α1-adrenergic receptor agonist, was administered to determine the bolus dose required to increase BP by 25 mmHg, an index of vascular α1-adrenergic receptor responsiveness. HBP (P <0.01), male sex (P =0.04), and higher BMI (P <0.01) were all associated with reduced β-adrenergic receptor responsiveness, with a similar trend observed for African-American race (P =0.07). Conversely, α1-adrenergic receptor responsiveness was increased in association with HBP (P <0.01), female sex (P <0.01), and African-American race (P <0.01). Conclusion In the early stages of hypertension, cardiovascular β-adrenergic receptors demonstrate blunted responsiveness, whereas conversely α1-adrenergic receptors exhibit increased responsiveness. This pattern of receptor changes is especially evident in men and African-Americans, is exacerbated by obesity, and may contribute to the development of cardiovascular disease. PMID:28306633 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28306633','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28306633">Race and sex differences in cardiovascular α-adrenergic and β-adrenergic receptor responsiveness in men and women with high blood pressure.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Sherwood, Andrew; Hill, LaBarron K; Blumenthal, James A; Johnson, Kristy S; Hinderliter, Alan L 2017-05-01 Hypertension is associated with unfavorable changes in adrenergic receptor responsiveness, but the relationship of race and sex to adrenergic receptor responsiveness in the development of cardiovascular disease is unclear. This study examined α-adrenergic and ß-adrenergic receptor responsiveness in African-American and white men and women with untreated high blood pressure (BP) (HBP) and with normal BP. The study sample comprised 161 African-American and white men and women in the age range 25-45 years. Isoproterenol, a nonselective ß-adrenergic receptor agonist, was administered intravenously to determine the bolus dose required to increase heart rate by 25 bpm, an index of β-adrenergic receptor responsiveness. Similarly, phenylephrine, an α1-adrenergic receptor agonist, was administered to determine the bolus dose required to increase BP by 25 mmHg, an index of vascular α1-adrenergic receptor responsiveness. HBP (P < 0.01), male sex (P = 0.04), and higher BMI (P < 0.01) were all associated with reduced β-adrenergic receptor responsiveness, with a similar trend observed for African-American race (P = 0.07). Conversely, α1-adrenergic receptor responsiveness was increased in association with HBP (P < 0.01), female sex (P < 0.01), and African-American race (P < 0.01). In the early stages of hypertension, cardiovascular β-adrenergic receptors demonstrate blunted responsiveness, whereas conversely α1-adrenergic receptors exhibit increased responsiveness. This pattern of receptor changes is especially evident in men and African-Americans, is exacerbated by obesity, and may contribute to the development of cardiovascular disease. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28285190','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28285190">Nitrate decreases xanthine oxidoreductase-mediated nitrite reductase activity and attenuates vascular and blood pressure responses to nitrite.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Damacena-Angelis, Célio; Oliveira-Paula, Gustavo H; Pinheiro, Lucas C; Crevelin, Eduardo J; Portella, Rafael L; Moraes, Luiz Alberto B; Tanus-Santos, Jose E 2017-08-01 Nitrite and nitrate restore deficient endogenous nitric oxide (NO) production as they are converted back to NO, and therefore complement the classic enzymatic NO synthesis. Circulating nitrate and nitrite must cross membrane barriers to produce their effects and increased nitrate concentrations may attenuate the nitrite influx into cells, decreasing NO generation from nitrite. Moreover, xanthine oxidoreductase (XOR) mediates NO formation from nitrite and nitrate. However, no study has examined whether nitrate attenuates XOR-mediated NO generation from nitrite. We hypothesized that nitrate attenuates the vascular and blood pressure responses to nitrite either by interfering with nitrite influx into vascular tissue, or by competing with nitrite for XOR, thus inhibiting XOR-mediated NO generation. We used two independent vascular function assays in rats (aortic ring preparations and isolated mesenteric arterial bed perfusion) to examine the effects of sodium nitrate on the concentration-dependent responses to sodium nitrite. Both assays showed that nitrate attenuated the vascular responses to nitrite. Conversely, the aortic responses to the NO donor DETANONOate were not affected by sodium nitrate. Further confirming these results, we found that nitrate attenuated the acute blood pressure lowering effects of increasing doses of nitrite infused intravenously in freely moving rats. The possibility that nitrate could compete with nitrite and decrease nitrite influx into cells was tested by measuring the accumulation of nitrogen-15-labeled nitrite ( 15 N-nitrite) by aortic rings using ultra-performance liquid chromatography tandem mass-spectrometry (UPLC-MS/MS). Nitrate exerted no effect on aortic accumulation of 15 N-nitrite. Next, we used chemiluminescence-based NO detection to examine whether nitrate attenuates XOR-mediated nitrite reductase activity. Nitrate significantly shifted the Michaelis Menten saturation curve to the right, with a 3-fold increase in the </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016AGUFMSM11A2139B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016AGUFMSM11A2139B">The Storm Time Ring Current Dynamics and Response to CMEs and CIRs Using Van Allen Probes Observations and CIMI Simulations</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Bingham, S.; Mouikis, C.; Kistler, L. M.; Fok, M. C. H.; Glocer, A.; Farrugia, C. J.; Gkioulidou, M.; Spence, H. E. 2016-12-01 The ring current responds differently to the different solar and interplanetary storm drivers such as coronal mass injections, (CMEs), and co-rotating interaction regions (CIRs). Delineating the differences in the ring current development between these two drivers will aid our understanding of the ring current dynamics. Using Van Allen Probes observations, we develop an empirical ring current model of the ring current pressure, the pressure anisotropy and the current density development during the storm phases for both types of storm drivers and for all MLTs inside L 6. In addition, we identify the populations (energy and species) responsible. We find that during the storm main phase and the early recovery phase the plasma sheet particles (10-80 keV) convecting from the nightside contribute the most on the ring current pressure and current density. However, during these phases, the main difference between CMEs and CIRs is in the O+ contribution. This empirical model is compared to the results of CIMI simulations of CMEs and CIRs where the model input is comprised of the superposed epoch solar wind conditions of the storms that comprise the empirical model, while different inner magnetosphere boundary conditions will be tested in order to match the empirical model results. Comparing the model and simulation results will fill our understanding of the ring current dynamics as part of the highly coupled inner magnetosphere system. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20010019249','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20010019249">Earth Observing-1 Advanced Land Imager: Radiometric Response Calibration</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Mendenhall, J. A.; Lencioni, D. E.; Evans, J. B. 2000-01-01 The Advanced Land Imager (ALI) is one of three instruments to be flown on the first Earth Observing mission (EO-1) under NASA's New Millennium Program (NMP). ALI contains a number of innovative features, including a wide field of view optical design, compact multispectral focal plane arrays, non-cryogenic HgCdTe detectors for the short wave infrared bands, and silicon carbide optics. This document outlines the techniques adopted during ground calibration of the radiometric response of the Advanced Land Imager. Results from system level measurements of the instrument response, signal-to-noise ratio, saturation radiance, and dynamic range for all detectors of every spectral band are also presented. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1324074-atomistic-material-behavior-extreme-pressures','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1324074-atomistic-material-behavior-extreme-pressures">Atomistic material behavior at extreme pressures</a> <a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a> Beland, Laurent K.; Osetskiy, Yury N.; Stoller, Roger E. 2016-08-05 Computer simulations are routinely performed to model the response of materials to extreme environments, such as neutron (or ion) irradiation. The latter involves high-energy collisions from which a recoiling atom creates a so-called atomic displacement cascade. These cascades involve coordinated motion of atoms in the form of supersonic shockwaves. These shockwaves are characterized by local atomic pressures >15 GPa and interatomic distances <2 Å. Similar pressures and interatomic distances are observed in other extreme environment, including short-pulse laser ablation, high-impact ballistic collisions and diamond anvil cells. Displacement cascade simulations using four different force fields, with initial kinetic energies ranging frommore » 1 to 40 keV, show that there is a direct relationship between these high-pressure states and stable defect production. An important shortcoming in the modeling of interatomic interactions at these short distances, which in turn determines final defect production, is brought to light.« less </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24118408','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24118408">Physical activity levels and torso orientations of hospitalized patients at risk of developing a pressure injury: an observational study.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Chaboyer, Wendy; Mills, Peter M; Roberts, Shelley; Latimer, Sharon 2015-02-01 Pressure injury guidelines recommend regular repositioning yet patients' mobility and repositioning patterns are unknown. An observational study using activity monitors was undertaken to describe the 24 h activity patterns of 84 hospitalized patients at risk of developing a pressure injury. The vast majority of participants' time was spent in the sedentary activity range (94% ± 3%) followed by the light range (5% ± 4 %). Patients changed their posture a median of 94 (interquartile range 48) time in the 24-h period (range 11-154), or ≈ 3.8 times per hour. Although a main focus for pressure injury prevention has been on repositioning, this study shows that patients with restricted mobility are actually moving quite often. Therefore, it might be appropriate to focus more attention on other pressure injury prevention strategies such as adequate nutrition, appropriate support surfaces and good skin care. © 2013 Wiley Publishing Asia Pty Ltd. </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active">22</li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_23" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active">23</li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="441"> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22947434','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22947434">Head orientation affects the intracranial pressure response resulting from shock wave loading in the rat.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Dal Cengio Leonardi, Alessandra; Keane, Nickolas J; Bir, Cynthia A; Ryan, Anne G; Xu, Liaosa; Vandevord, Pamela J 2012-10-11 Since an increasing number of returning military personnel are presenting with neurological manifestations of traumatic brain injury (TBI), there has been a great focus on the effects resulting from blast exposure. It is paramount to resolve the physical mechanism by which the critical stress is being inflicted on brain tissue from blast wave encounters with the head. This study quantitatively measured the effect of head orientation on intracranial pressure (ICP) of rats exposed to a shock wave. Furthermore, the study examined how skull maturity affects ICP response of animals exposed to shock waves at various orientations. Results showed a significant increase in ICP values in larger rats at any orientation. Furthermore, when side-ICP values were compared to the other orientations, the peak pressures were significantly lower suggesting a relation between ICP and orientation of the head due to geometry of the skull and location of sutures. This finding accentuates the importance of skull dynamics in explaining possible injury mechanisms during blast. Also, the rate of pressure change was measured and indicated that the rate was significantly higher when the top of the head was facing the shock front. The results confirm that the biomechanical response of the superior rat skull is distinctive compared to other areas of the skull, suggesting a skull flexure mechanism. These results not only present insights into the mechanism of brain injury, but also provide information which can be used for designing more effective protective head gear. Copyright © 2012 Elsevier Ltd. All rights reserved. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018JGRA..123.3170Z','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018JGRA..123.3170Z">The Detached Auroras Induced by the Solar Wind Pressure Enhancement in Both Hemispheres From Imaging and In Situ Particle Observations</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Zhou, Su; Luan, Xiaoli; Søraas, Finn; Østgaard, Nikolai; Raita, Tero 2018-04-01 This paper presents simultaneous detached proton auroras that appeared in both hemispheres at 11:06 UT, 08 March 2012, just 2 min after a sudden solar wind pressure enhancement ( 11:04 UT) hit the Earth. They were observed under northward interplanetary magnetic field Bz condition and during the recovery phase of a moderate geomagnetic storm. In the Northern Hemisphere, Defense Meteorological Satellite Program/Special Sensor Ultraviolet Spectrographic Imager observed that the detached arc occurred within 60°-65° magnetic latitude and covered a few magnetic local time (MLT) hours ranging from 0530 to 0830 MLT with a possible extension toward noon. At the same time (11:06 UT), Polar Orbiting Environment Satellites 19 detected a detached proton aurora around 1300 MLT in the Southern Hemisphere, centering 62° magnetic latitude, which was at the same latitudes as the northern detached arc. This southern aurora was most probably a part of a dayside detached arc that was conjugate to the northern one. In situ particle observations indicated that the detached auroras were dominated by protons/ions with energies ranging from around 20 keV to several hundreds of keV, without obvious electron precipitations. These detached arcs persisted for less than 6 min, consistent with the impact from pressure enhancement and the observed electromagnetic ion cyclotron (EMIC) waves. It is suggested that the increasing solar wind pressure pushed the hot ions in the ring current closer to Earth where the steep gradient of cold plasma favored EMIC wave growth. By losing energy to EMIC waves the energetic protons (>20 keV) were scattered into the loss cone and produced the observed detached proton auroras. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1991SPIE.1427..273L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1991SPIE.1427..273L">Effects of pressure rise on cw laser ablation of tissue</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> LeCarpentier, Gerald L.; Motamedi, Massoud; Welch, Ashley J. 1991-06-01 The objectives of this research were to identify mechanisms responsible for the initiation of continuous wave (cw) laser ablation of tissue and investigate the role of pressure in the ablation process. Porcine aorta samples were irradiated in a chamber pressurized from 1 X 10-4 to 12 atmospheres absolute pressure. Acrylic and Zn-Se windows in the experimental pressure chamber allowed video and infrared cameras to simultaneously record mechanical and thermal events associated with cw argon laser ablation of these samples. Video and thermal images of tissue slabs documented the explosive nature of cw laser ablation of soft biological media and revealed similar ablation threshold temperatures and ablation onset times under different environmental pressures; however, more violent initiation explosions with decreasing environmental pressures were observed. These results suggest that ablation initiates with thermal alterations in the mechanical strength of the tissue and proceeds with an explosion induced by the presence superheated liquid within the tissue. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014AGUFM.G23A0462P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014AGUFM.G23A0462P">Bridging a possible gap of GRACE observations in the Arctic Ocean using existing GRACE data and in situ bottom pressure sensors</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Peralta Ferriz, C.; Morison, J. 2014-12-01 Since 2003, the Gravity Recovery and Climate Experiment (GRACE) satellite system has provided the means of investigating month-to-month to inter-annual variability of, among many other things, Arctic Ocean circulation over the entire Arctic Basin. Such a comprehensive picture could not have been achieved with the limited in situ pressure observations available. Results from the first 10 years of ocean bottom pressure measurements from GRACE in the Arctic Ocean reveal distinct patterns of ocean variability that are strongly associated with changes in large-scale atmospheric circulation (Peralta-Ferriz et al., 2014): the leading mode of variability being a wintertime basin-coherent mass change driven by winds in the Nordic Seas; the second mode of variability corresponding to a mass signal coherent along the Siberian shelves, and driven by the Arctic Oscillation; and the third mode being a see-saw between western and eastern Arctic shelves, also driven by the large-scale wind patterns. In order to understand Arctic Ocean changes, it is fundamental to continue to track ocean bottom pressure. Our concern is what to do if the present GRACE system, which is already well beyond its design lifetime, should fail before its follow-on is launched, currently estimated to be in 2017. In this work, we regress time series of pressure from the existing and potential Arctic Ocean bottom pressure recorder locations against the fundamental modes of bottom pressure variation. Our aim is to determine the optimum combination of in situ measurements to represent the broader scale variability now observed by GRACE. With this understanding, we can be better prepared to use in situ observations to at least partially cover a possible gap in GRACE coverage. Reference:Peralta-Ferriz, Cecilia, James H. Morison, John M. Wallace, Jennifer A. Bonin, Jinlun Zhang, 2014: Arctic Ocean Circulation Patterns Revealed by GRACE. J. Climate, 27, 1445-1468. doi: http://dx.doi.org/10.1175/JCLI-D-13-00013.1 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22657898-design-principles-highpressure-force-fields-aqueous-tmao-solutions-from-ambient-kilobar-pressures','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22657898-design-principles-highpressure-force-fields-aqueous-tmao-solutions-from-ambient-kilobar-pressures">Design principles for high–pressure force fields: Aqueous TMAO solutions from ambient to kilobar pressures</a> <a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a> Hölzl, Christoph; Horinek, Dominik, E-mail: dominik.horinek@ur.de; Kibies, Patrick Accurate force fields are one of the major pillars on which successful molecular dynamics simulations of complex biomolecular processes rest. They have been optimized for ambient conditions, whereas high-pressure simulations become increasingly important in pressure perturbation studies, using pressure as an independent thermodynamic variable. Here, we explore the design of non-polarizable force fields tailored to work well in the realm of kilobar pressures – while avoiding complete reparameterization. Our key is to first compute the pressure-induced electronic and structural response of a solute by combining an integral equation approach to include pressure effects on solvent structure with a quantum-chemical treatmentmore » of the solute within the embedded cluster reference interaction site model (EC-RISM) framework. Next, the solute’s response to compression is taken into account by introducing pressure-dependence into selected parameters of a well-established force field. In our proof-of-principle study, the full machinery is applied to N,N,N-trimethylamine-N-oxide (TMAO) in water being a potent osmolyte that counteracts pressure denaturation. EC-RISM theory is shown to describe well the charge redistribution upon compression of TMAO(aq) to 10 kbar, which is then embodied in force field molecular dynamics by pressure-dependent partial charges. The performance of the high pressure force field is assessed by comparing to experimental and ab initio molecular dynamics data. Beyond its broad usefulness for designing non-polarizable force fields for extreme thermodynamic conditions, a good description of the pressure-response of solutions is highly recommended when constructing and validating polarizable force fields.« less </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27083705','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27083705">Design principles for high-pressure force fields: Aqueous TMAO solutions from ambient to kilobar pressures.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Hölzl, Christoph; Kibies, Patrick; Imoto, Sho; Frach, Roland; Suladze, Saba; Winter, Roland; Marx, Dominik; Horinek, Dominik; Kast, Stefan M 2016-04-14 Accurate force fields are one of the major pillars on which successful molecular dynamics simulations of complex biomolecular processes rest. They have been optimized for ambient conditions, whereas high-pressure simulations become increasingly important in pressure perturbation studies, using pressure as an independent thermodynamic variable. Here, we explore the design of non-polarizable force fields tailored to work well in the realm of kilobar pressures--while avoiding complete reparameterization. Our key is to first compute the pressure-induced electronic and structural response of a solute by combining an integral equation approach to include pressure effects on solvent structure with a quantum-chemical treatment of the solute within the embedded cluster reference interaction site model (EC-RISM) framework. Next, the solute's response to compression is taken into account by introducing pressure-dependence into selected parameters of a well-established force field. In our proof-of-principle study, the full machinery is applied to N,N,N-trimethylamine-N-oxide (TMAO) in water being a potent osmolyte that counteracts pressure denaturation. EC-RISM theory is shown to describe well the charge redistribution upon compression of TMAO(aq) to 10 kbar, which is then embodied in force field molecular dynamics by pressure-dependent partial charges. The performance of the high pressure force field is assessed by comparing to experimental and ab initio molecular dynamics data. Beyond its broad usefulness for designing non-polarizable force fields for extreme thermodynamic conditions, a good description of the pressure-response of solutions is highly recommended when constructing and validating polarizable force fields. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20040172696&hterms=Sex&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D70%26Ntt%3DSex','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20040172696&hterms=Sex&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D70%26Ntt%3DSex">Distribution and observed associations of orthostatic blood pressure changes in elderly general medicine outpatients</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Robertson, D.; DesJardin, J. A.; Lichtenstein, M. J. 1998-01-01 Factors associated with orthostatic blood pressure change in elderly outpatients were determined by surveying 398 medical clinical outpatients aged 65 years and older. Blood pressure was measured with random-zero sphygmomanometers after patients were 5 minutes in a supine and 5 minutes in a standing position. Orthostatic blood pressure changes were at normally distributed levels with systolic and diastolic pressures dropping an average of 4 mm Hg (standard deviation [SD]=15 mm Hg) and 2 mm Hg (SD=11 mm Hg), respectively. Orthostatic blood pressure changes were unassociated with age, race, sex, body mass, time since eating, symptoms, or other factors. According to multiple linear regression analysis, supine systolic pressure, chronic obstructive pulmonary disease (COPD), and diabetes mellitus were associated with a decrease in systolic pressure on standing. Hypertension, antiarthritic drugs, and abnormal heartbeat were associated with an increase in systolic pressure on standing. For orthostatic diastolic pressure changes, supine diastolic pressure and COPD were associated with a decrease in diastolic pressure on standing. Congestive heart failure was associated with an increase in standing diastolic pressure. Using logistic regression analysis, only supine systolic pressure was associated with a greater than 20-mm Hg drop in systolic pressure (n=53, prevalence=13%). Supine diastolic pressure and COPD were the only variables associated with a greater than 20-mm Hg drop in diastolic pressure (n=16, prevalence=4%). These factors may help physicians in identifying older persons at risk for having orthostatic hypotension. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017EGUGA..19.4106D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017EGUGA..19.4106D">Hydro-mechanical pressure response to fluid injection into finite aquifers highlights the non-local behavior of storage</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> De Simone, Silvia; Carrera, Jesus 2017-04-01 Specific storage reflects the volumetric deformation capacity of permeable media. Classical groundwater hydrology equals elastic storage to medium compressibility, which is a constant-in-time and locally-defined parameter. This allows simplifying the flow equation into a linear diffusion equation that is relatively easy to solve. However, the hydraulic gradients, generated by fluid injection or pumping, act as forces that push the medium in the direction of flow causing it to deform, even in regions where pressure has not changed. Actual deformation depends on the elastic properties of the medium, but also on aquifer geometry and on surrounding strata, which act like constraints to displacements. Therefore the storage results to be non-local (i.e., the volume of water released at a point depends on the poroelastic response over the whole aquifer) and the proper evaluation of transient pressure requires acknowledging the hydro-mechanical (HM) coupling, which is generally disregarded by conventional hydrogeology. Here we discuss whether HM coupling effects are relevant, which is of special interest for the activities of enhanced geothermics, waste disposal, CO2 storage or shale gas extraction. We propose analytic solutions to the HM problem of fluid injection (or extraction) into finite aquifers with one-dimensional or cylindrical geometries. We find that the deviation respect to traditional purely hydraulic solutions is significant when the aquifer has limited capacity to deform. The most relevant implications are that the response time is faster and the pressure variation greater than expected, which may be relevant for aquifer characterization and for the evaluation of pressure build-up due to fluid injection. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=causes+AND+urbanization&id=EJ398642','ERIC'); return false;" href="https://eric.ed.gov/?q=causes+AND+urbanization&id=EJ398642">Is Marriage Delay a Multiphasic Response to Pressures for Fertility Decline? The Case of Sri Lanka.</a> <a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a> Caldwell, John; And Others 1989-01-01 Investigated causes for rise in female age of marriage in Sri Lanka, studying 10,964 persons from 1,974 households. Found that rise in marriage age was not primarily a response to social pressure for fertility decline, but rather a result of urbanization, higher levels of education, unemployment, and consequent decline in parentally arranged early… </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28802637','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28802637">Blood pressure responses to dietary sodium: Association with autonomic cardiovascular function in normotensive adults.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Matthews, Evan L; Brian, Michael S; Edwards, David G; Stocker, Sean D; Wenner, Megan M; Farquhar, William B 2017-12-01 Blood pressure responses to dietary sodium vary widely person-to-person. Salt sensitive rodent models display altered autonomic function, a trait thought to contribute to poor cardiovascular health. Thus, we hypothesized that increased salt sensitivity (SS) in normotensive humans would be associated with increased muscle sympathetic nerve activity (MSNA), decreased high frequency heart rate variability (HF-HRV), and decreased baroreflex sensitivity. Healthy normotensive men and women completed 1week of high (300mmol·day -1 ) and 1week of low (20mmol·day -1 ) dietary sodium (random order) with 24h mean arterial pressure (MAP) assessed on the last day of each diet to assess SS. Participants returned to the lab under habitual sodium conditions for testing. Forty-two participants are presented in this analysis, 19 of which successful MSNA recordings were obtained (n=42: age 39±2yrs., BMI 24.3±0.5kg·(m 2 ) -1 , MAP 83±1mmHg, habitual urine sodium 93±7mmol·24h -1 ; n=19: MSNA burst frequency 20±2 bursts·min -1 ). The variables of interest were linearly regressed over the magnitude of SS. Higher SS was associated with increased MSNA (burst frequency: r=0.469, p=0.041), decreased HF-HRV (r=-0.349, p=0.046), and increased LF/HF-HRV (r=0.363, p=0.034). SS was not associated with sympathetic or cardiac baroreflex sensitivity (p>0.05). Multiple regression analysis accounting for age found that age, not SS, independently predicted HF-HRV (age adjusted no longer significant; p=0.369) and LF/HF-HRV (age adjusted p=0.273). These data suggest that age-related salt sensitivity of blood pressure in response to dietary sodium is associated with altered resting autonomic cardiovascular function. Copyright © 2017 Elsevier B.V. All rights reserved. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20030053447&hterms=balance+sheet&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D50%26Ntt%3Dbalance%2Bsheet','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20030053447&hterms=balance+sheet&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D50%26Ntt%3Dbalance%2Bsheet">Relation between Pressure Balance Structures and Polar Plumes from Ulysses High Latitude Observations</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Yamauchi, Yohei; Suess, Steven T.; Sakurai, Takashi 2002-01-01 Ulysses observations have shown that pressure balance structures (PBSs) are a common feature in high-latitude, fast solar wind near solar minimum. Previous studies of Ulysses/SWOOPS plasma data suggest these PBSs may be remnants of coronal polar plumes. Here we find support for this suggestion in an analysis of PBS magnetic structure. We used Ulysses magnetometer data and applied a minimum variance analysis to magnetic discontinuities in PBSs. We found that PBSs preferentially contain tangential discontinuities, as opposed to rotational discontinuities and to non-PBS regions in the solar wind. This suggests that PBSs contain structures like current sheets or plasmoids that may be associated with network activity at the base of plumes. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014AcAau..94..834W','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014AcAau..94..834W">Experimental investigation on flow patterns of RP-3 kerosene under sub-critical and supercritical pressures</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Wang, Ning; Zhou, Jin; Pan, Yu; Wang, Hui 2014-02-01 Active cooling with endothermic hydrocarbon fuel is proved to be one of the most promising approaches to solve the thermal problem for hypersonic aircraft such as scramjet. The flow patterns of two-phase flow inside the cooling channels have a great influence on the heat transfer characteristics. In this study, phase transition processes of RP-3 kerosene flowing inside a square quartz-glass tube were experimentally investigated. Three distinct phase transition phenomena (liquid-gas two phase flow under sub-critical pressures, critical opalescence under critical pressure, and corrugation under supercritical pressures) were identified. The conventional flow patterns of liquid-gas two phase flow, namely bubble flow, slug flow, churn flow and annular flow are observed under sub-critical pressures. Dense bubble flow and dispersed flow are recognized when pressure is increased towards the critical pressure whilst slug flow, churn flow and annular flow disappear. Under critical pressure, the opalescence phenomenon is observed. Under supercritical pressures, no conventional phase transition characteristics, such as bubbles are observed. But some kind of corrugation appears when RP-3 transfers from liquid to supercritical. The refraction index variation caused by sharp density gradient near the critical temperature is thought to be responsible for this corrugation. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4508214','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4508214">Observed Parent-Child Relationship Quality Predicts Antibody Response to Vaccination in Children</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> O'Connor, Thomas G; Wang, Hongyue; Moynihan, Jan A; Wyman, Peter A.; Carnahan, Jennifer; Lofthus, Gerry; Quataert, Sally A.; Bowman, Melissa; Burke, Anne S.; Caserta, Mary T 2015-01-01 Background Quality of the parent-child relationship is a robust predictor of behavioral and emotional health for children and adolescents; the application to physical health is less clear. Methods We investigated the links between observed parent-child relationship quality in an interaction task and antibody response to meningococcal conjugate vaccine in a longitudinal study of 164 ambulatory 10-11 year-old children; additional analyses examine associations with cortisol reactivity, BMI, and somatic illness. Results Observed negative/conflict behavior in the interaction task predicted a less robust antibody response to meningococcal serotype C vaccine in the child over a 6 month-period, after controlling for socio-economic and other covariates. Observer rated interaction conflict also predicted increased cortisol reactivity following the interaction task and higher BMI, but these factors did not account for the link between relationship quality and antibody response. Conclusions The results begin to document the degree to which a major source of child stress exposure, parent-child relationship conflict, is associated with altered immune system development in children, and may constitute an important public health consideration. PMID:25862953 </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017APS..MAR.X9008C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017APS..MAR.X9008C">Study on the mesophase development of pressure-responsive ABC triblock copolymers</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Cho, Junhan Here we focus on the revelation of new nanoscale morphologies for a molten compressible polymeric surfactant through a compressible self-consistent field approach. A linear ABC block copolymer is set to allow a disparity in the propensities for curved interfaces and in pressure responses of ij-pairs. Under these conditions, the copolymer evolves into noble morphologies at selected segregation levels such as networks with tetrapod connections, rectangularly packed cylinders in a 2-dimensional array, and also body-centered cubic phases. Those new structures are considered to turn up by interplay between disparity in the densities of block domains and packing frustration. Comparison with the classical mesophase structures is also given. The author acknowledges the support from the Center for Photofunctional Energy Materials (GRRC). </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017HPR....37..415F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017HPR....37..415F">Optimization of high pressure bioactive compounds extraction from pansies (Viola × wittrockiana) by response surface methodology</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Fernandes, Luana; Casal, Susana I. P.; Pereira, José A.; Ramalhosa, Elsa; Saraiva, Jorge A. 2017-07-01 Response surface methodology (RSM) was employed for the first time to optimize high pressure extraction (HPE) conditions of bioactive compounds from pansies, namely: pressure (X1: 0-500 MPa), time (X2: 5-15 min) and ethanol concentration (X3: 0-100%). Consistent fittings using second-order polynomial models were obtained for flavonoids, tannins, anthocyanins, total reducing capacity (TRC) and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity. The optimum extraction conditions based on combination responses for TRC, tannins and anthocyanins were: X1 = 384 MPa, X2 = 15 min and X3 = 35% (v/v) ethanol, shortening the extraction time when compared to the classic method of stirring (approx. 24 h). When the optimum extraction conditions were applied, 65.1 mg of TRC, 42.8 mg of tannins and 56.15 mg of anthocyanins/g dried flower were obtained. Thus, HPE has shown to be a promising technique to extract bioactive compounds from pansies, by reducing the extraction time and by using green solvents (ethanol and water), for application in diverse industrial fields. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://pubs.er.usgs.gov/publication/70192838','USGSPUBS'); return false;" href="https://pubs.er.usgs.gov/publication/70192838">Significance of beating observed in earthquake responses of buildings</a> <a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a> Çelebi, Mehmet; Ghahari, S. F.; Taciroglu, E. 2016-01-01 The beating phenomenon observed in the recorded responses of a tall building in Japan and another in the U.S. are examined in this paper. Beating is a periodic vibrational behavior caused by distinctive coupling between translational and torsional modes that typically have close frequencies. Beating is prominent in the prolonged resonant responses of lightly damped structures. Resonances caused by site effects also contribute to accentuating the beating effect. Spectral analyses and system identification techniques are used herein to quantify the periods and amplitudes of the beating effects from the strong motion recordings of the two buildings. Quantification of beating effects is a first step towards determining remedial actions to improve resilient building performance to strong earthquake induced shaking. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20436351','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20436351">Women with TT genotype for eNOS gene are more responsive in lowering blood pressure in response to exercise.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Sponton, Carlos H G; Rezende, Tiago M; Mallagrino, Pamella A; Franco-Penteado, Carla F; Bezerra, Marcos André C; Zanesco, Angelina 2010-12-01 The aim of this study was to investigate whether -786T>C endothelial nitric oxide synthase (eNOS) gene polymorphism might influence the effect of long-term exercise training (ET) on the blood pressure and its relationship with NO production in healthy postmenopausal women. Longitudinal study. Fifty-five postmenopausal women were studied in a double-blinded design. ET was performed for 3 days a week, each session consisting of 60 min during 6 months, in an intensity of 50-70% VO2max. After that, eNOS genotype analysis was performed and women were divided into two groups: TC+CC (n=41) and TT (n=14) genotype. No changes were found in the anthropometric parameters after ET in both the groups. Systolic and diastolic BP values were significantly reduced in both the groups, but women with TT genotype were more responsive in lowering BP as compared with those with TC+CC genotype. Plasma nitrite/nitrate concentrations were similar at baseline in both the groups, but the magnitude of increment in NO production in response to ET was higher in women with TT genotype as compared with those with TC+CC genotype. Our study shows clearly that women with or without eNOS gene polymorphism had no differences in NO production at basal conditions, but when physical exercise is applied an evident difference is detected showing that the presence of -786T>C eNOS gene polymorphism had a significant impact in the health-promoting effect of aerobic physical training on the blood pressure in postmenopausal women. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017EGUGA..1919099T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017EGUGA..1919099T">Tsunami simulation method initiated from waveforms observed by ocean bottom pressure sensors for real-time tsunami forecast; Applied for 2011 Tohoku Tsunami</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Tanioka, Yuichiro 2017-04-01 After tsunami disaster due to the 2011 Tohoku-oki great earthquake, improvement of the tsunami forecast has been an urgent issue in Japan. National Institute of Disaster Prevention is installing a cable network system of earthquake and tsunami observation (S-NET) at the ocean bottom along the Japan and Kurile trench. This cable system includes 125 pressure sensors (tsunami meters) which are separated by 30 km. Along the Nankai trough, JAMSTEC already installed and operated the cable network system of seismometers and pressure sensors (DONET and DONET2). Those systems are the most dense observation network systems on top of source areas of great underthrust earthquakes in the world. Real-time tsunami forecast has depended on estimation of earthquake parameters, such as epicenter, depth, and magnitude of earthquakes. Recently, tsunami forecast method has been developed using the estimation of tsunami source from tsunami waveforms observed at the ocean bottom pressure sensors. However, when we have many pressure sensors separated by 30km on top of the source area, we do not need to estimate the tsunami source or earthquake source to compute tsunami. Instead, we can initiate a tsunami simulation from those dense tsunami observed data. Observed tsunami height differences with a time interval at the ocean bottom pressure sensors separated by 30 km were used to estimate tsunami height distribution at a particular time. In our new method, tsunami numerical simulation was initiated from those estimated tsunami height distribution. In this paper, the above method is improved and applied for the tsunami generated by the 2011 Tohoku-oki great earthquake. Tsunami source model of the 2011 Tohoku-oki great earthquake estimated using observed tsunami waveforms, coseimic deformation observed by GPS and ocean bottom sensors by Gusman et al. (2012) is used in this study. The ocean surface deformation is computed from the source model and used as an initial condition of tsunami </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/14979862','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/14979862">Anger response styles and blood pressure: at least don't ruminate about it!</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Hogan, Brenda E; Linden, Wolfgang 2004-02-01 Research on anger suggests a link with blood pressure (BP), but the findings are complex and highly variable; this is at least partly attributable to measurement issues. In this study we used a new model of anger responding that comprises 6 independent anger response styles in 2 dimensions: Aggression, Assertion, Social Support Seeking, Diffusion, Avoidance, and Rumination. Linear and interactive relations between the anger response styles and resting and ambulatory BP were tested, controlling for traditional risk factors and level of hostility. Data from 2 samples of different cardiovascular health status were examined. In Study 1, 109 healthy participants (45 men and 64 women) were recruited. Study 2 involved a sample of 159 hypertensive patients (90 men and 69 women). All participants provided demographic and health information; completed the Behavioral Anger Response Questionnaire, a hostility measure; and underwent resting BP measurement. Study 2 participants also provided 24-hr ambulatory BPs. Examination of linear effects revealed inconsistent associations between anger response styles and BP. The moderating effect of Rumination on the relationship between the other anger response styles and BP was examined next. Rumination had a deleterious influence on the relation between Avoidance and Assertion and resting and ambulatory BP levels. The moderating influence of Rumination on Social Support Seeking varied between the genders. Overall, the results suggest that rumination is a critical moderating variable in the relation of anger and BP. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016isms.confEWK14I','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016isms.confEWK14I">Observation of Ortho-Para Dependence of Pressure Broadening Coefficient in Acetylene νb{1}+νb{3} Vibration Band Using Dual-Comb Spectroscopy</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Iwakuni, Kana; Okubo, Sho; Inaba, Hajime; Onae, Atsushi; Hong, Feng-Lei; Sasada, Hiroyuki; Yamada, Koichi MT 2016-06-01 We observe that the pressure-broadening coefficients depend on the ortho-para levels. The spectrum is taken with a dual-comb spectrometer which has the resolution of 48 MHz and the frequency accuracy of 8 digit when the signal-to-noise ratio is more than 20. In this study, about 4.4-Tz wide spectra of the P(31) to R(31) transitions in the νb{1}+νb{3} vibration band of 12C_2H_2 are observed at the pressure of 25, 60, 396, 1047, 1962 and 2654 Pa. Each rotation-vibration absorption line is fitted to Voight function and we determined pressure-broadening coefficients for each rotation-vibration transition. The Figure shows pressure broadening coefficient as a function of m. Here m is J"+1 for R and -J" for P-branch. The graph shows obvious dependence on ortho and para. We fit it to Pade function considering the population ratio of three-to-one for the ortho and para levels. This would lead to detailed understanding of the pressure boarding mechanism. S. Okubo et al., Applied Physics Express 8, 082402 (2015) </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active">23</li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_24" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active">24</li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="461"> <li> <a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA538038','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA538038">Observation of an Ultrahard Phase of Graphite Quenched from High-pressure</a> <a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a> 2011-02-01 Polycrystalline NaCl at High Pressures and 300 °K. J. Geophys. Res. 1978, 83, 1257–1268. 23. Selvi , E.; Ma, Y.; Askoy, R.; Ertas, A.; White, A. High...Pressure X-ray Diffraction Study of Tungsten Disulfide. J. Phys. Chem. Solids 2006, 67, 2183–2186. 24. Askoy, R.; Ma, Y.; Selvi , E.; Chyu, M. C </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3065933','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3065933">Genetic Variation in the Presynaptic Norepinephrine Transporter is Associated with Blood Pressure Responses to Exercise in Healthy Humans</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Kohli, Utkarsh; Hahn, Maureen K.; English, Brett A.; Sofowora, Gbenga G.; Muszkat, Mordechai; Li, Chun; Blakely, Randy D.; Stein, C. Michael; Kurnik, Daniel 2011-01-01 Background The presynaptic norepinephrine (NE) transporter (NET) mediates synaptic clearance and recycling of NE. NET-deficient transgenic mice have elevated blood pressure, heart rate, and catecholamine concentrations. However, the in vivo effects of common NET variants on cardiovascular regulation at rest and during exercise are unknown. Methods We studied cardiovascular responses and plasma catecholamine concentrations at rest and during bicycle exercise at increasing workloads (25, 50 and 75 W) in 145 healthy subjects. We used multiple linear regressions to analyze the effect of common, purportedly functional polymorphisms in NET (rs2242446 and rs28386840) on cardiovascular measures. Results 44% and 58.9% of subjects carried at least one variant allele for NET T-182C and A-3081T, respectively. Systolic blood pressure (SBP) during exercise and SBP area-under-the-curve were higher in carriers of variant NET alleles (P=0.003 and 0.009 for T-182C and A-3081T, respectively) and NET haplotype -182C/-081T compared to -82T/-3081A (all P<0.01). Diastolic blood pressure (DBP) during exercise was also higher at lower, but not at higher exercise stages in carriers of NET -182C (P<0.01) and -081T (P< 0.05). NET genotypes were not associated with catecholamine concentrations or heart rate. Conclusion Common genetic NET variants (-182C and -081T) are associated with greater blood pressure response to exercise in humans. PMID:21412203 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23427083','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23427083">Proximal tubule-dominant transfer of AT(1a) receptors induces blood pressure responses to intracellular angiotensin II in AT(1a) receptor-deficient mice.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Li, Xiao C; Zhuo, Jia L 2013-04-15 The role of intracellular ANG II in proximal tubules of the kidney remains poorly understood. We tested the hypothesis that proximal tubule-dominant transfer of AT(1a) receptors in the cortex mediates intracellular ANG II-induced blood pressure responses in AT(1a) receptor-deficient (Agtr1a-/-) mice. A GFP-tagged AT(1a) receptor, AT(1a)R/GFP, and an enhanced cyan fluorescent intracellular ANG II fusion protein, ECFP/ANG II, were expressed in proximal tubules of Agtr1a-/- mouse kidneys via the adenoviral transfer using a sodium and glucose cotransporter 2 promoter. Transfer of AT(1a)R/GFP alone or with ECFP/ANG II induced proximal tubule-dominant expression of AT(1a)R/GFP and/or ECFP/ANG II with a peak response at 2 wk. No significant AT(1a)R/GFP and/or ECFP/ANG II expression was observed in the glomeruli, medulla, or extrarenal tissues. Transfer of AT(1a)R/GFP alone, but not ECFP/ANG II, increased systolic blood pressure by 12 ± 2 mmHg by day 14 (n = 9, P < 0.01). However, cotransfer of AT(1a)R/GFP with ECFP/ANG II increased blood pressure by 18 ± 2 mmHg (n = 12, P < 0.01). Twenty-four hour urinary sodium excretion was decreased by day 7 with proximal tubule-dominant transfer of AT(1a)R/GFP alone (P < 0.01) or with AT(1a)R/GFP and ECFP/ANG II cotransfer (P < 0.01). These responses were associated with twofold increases in phosphorylated ERK1/2, lysate, and membrane NHE-3 proteins in freshly isolated proximal tubules (P < 0.01). By contrast, transfer of control CMV-GFP (a recombinant human adenovirus type 5 expresses enhanced green fluorescent protein under the control of a cytomegalovirus (CMV) promoter), ECFP/ANG II, or a scrambled control ECFP/ANG IIc alone in proximal tubules had no effect on all indices. These results suggest that AT(1a) receptors and intracellular ANG II in proximal tubules of the kidney play an important physiological role in blood pressure regulation. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016AGUFMSA31A2387B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016AGUFMSA31A2387B">Mid-latitude response to geomagnetic storms observed in 630nm airglow over continental United States</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Bhatt, A.; Kendall, E. A. 2016-12-01 We present analysis of mid-latitude response observed to geomagnetic storms using the MANGO network consisting of all-sky cameras imaging 630nm emission over the continental United States. The response largely falls in two categories: Stable Auroral Red (SAR) arc and Large-scale traveling ionospheric disturbances (LSTIDs). However, outside of these phenomena, less often observed response include anomalous airglow brightening, bright swirls, and frozen in traveling structures. We will present an analysis of various events observed over 3 years of MANGO network operation, which started with two imagers in the western US with addition of new imagers in the last year. We will also present unusual north and northeastward propagating waves often observed in conjunction with diffuse aurora. Wherever possible, we will compare with observations from Boston University imagers located in Massachusetts and Texas. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/12397401','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/12397401">High-speed pressure clamp.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Besch, Stephen R; Suchyna, Thomas; Sachs, Frederick 2002-10-01 We built a high-speed, pneumatic pressure clamp to stimulate patch-clamped membranes mechanically. The key control element is a newly designed differential valve that uses a single, nickel-plated piezoelectric bending element to control both pressure and vacuum. To minimize response time, the valve body was designed with minimum dead volume. The result is improved response time and stability with a threefold decrease in actuation latency. Tight valve clearances minimize the steady-state air flow, permitting us to use small resonant-piston pumps to supply pressure and vacuum. To protect the valve from water contamination in the event of a broken pipette, an optical sensor detects water entering the valve and increases pressure rapidly to clear the system. The open-loop time constant for pressure is 2.5 ms for a 100-mmHg step, and the closed-loop settling time is 500-600 micros. Valve actuation latency is 120 micros. The system performance is illustrated for mechanically induced changes in patch capacitance. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013BGD....10.1635T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013BGD....10.1635T">Insights into mechanisms governing forest carbon response to nitrogen deposition: a model-data comparison using observed responses to nitrogen addition</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Thomas, R. Q.; Bonan, G. B.; Goodale, C. L. 2013-01-01 In many forest ecosystems, nitrogen (N) deposition enhances plant uptake of carbon dioxide, thus reducing climate warming from fossil fuel emissions. Therefore, accurately modeling how forest carbon (C) sequestration responds to N deposition is critical for understanding how future changes in N availability will influence climate. Here, we use observations of forest C response to N inputs along N deposition gradients and at five temperate forest sites with fertilization experiments to test and improve a~global biogeochemical model (CLM-CN 4.0). We show that the CLM-CN plant C growth response to N deposition was smaller than observed and the modeled response to N fertilization was larger than observed. A set of modifications to the CLM-CN improved the correspondence between model predictions and observational data (1) by increasing the aboveground C storage in response to historical N deposition (1850-2004) from 14 to 34 kg C per additional kg N added through deposition and (2) by decreasing the aboveground net primary productivity response to N fertilization experiments from 91 to 57 g C m-2 yr-1. Modeled growth response to N deposition was most sensitive to altering the processes that control plant N uptake and the pathways of N loss. The response to N deposition also increased with a more closed N cycle (reduced N fixation and N gas loss) and decreased when prioritizing microbial over plant uptake of soil inorganic N. The net effect of all the modifications to the CLM-CN resulted in greater retention of N deposition and a greater role of synergy between N deposition and rising atmospheric CO2 as a mechanism governing increases in temperate forest primary production over the 20th century. Overall, testing models with both the response to gradual increases in N inputs over decades (N deposition) and N pulse additions of N over multiple years (N fertilization) allows for greater understanding of the mechanisms governing C-N coupling. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013BGeo...10.3869T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013BGeo...10.3869T">Insights into mechanisms governing forest carbon response to nitrogen deposition: a model-data comparison using observed responses to nitrogen addition</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Thomas, R. Q.; Bonan, G. B.; Goodale, C. L. 2013-06-01 In many forest ecosystems, nitrogen (N) deposition enhances plant uptake of carbon dioxide, thus reducing climate warming from fossil fuel emissions. Therefore, accurately modeling how forest carbon (C) sequestration responds to N deposition is critical for understanding how future changes in N availability will influence climate. Here, we use observations of forest C response to N inputs along N deposition gradients and at five temperate forest sites with fertilization experiments to test and improve a global biogeochemical model (CLM-CN 4.0). We show that the CLM-CN plant C growth response to N deposition was smaller than observed and the modeled response to N fertilization was larger than observed. A set of modifications to the CLM-CN improved the correspondence between model predictions and observational data (1) by increasing the aboveground C storage in response to historical N deposition (1850-2004) from 14 to 34 kg C per additional kg N added through deposition and (2) by decreasing the aboveground net primary productivity response to N fertilization experiments from 91 to 57 g C m-2 yr-1. Modeled growth response to N deposition was most sensitive to altering the processes that control plant N uptake and the pathways of N loss. The response to N deposition also increased with a more closed N cycle (reduced N fixation and N gas loss) and decreased when prioritizing microbial over plant uptake of soil inorganic N. The net effect of all the modifications to the CLM-CN resulted in greater retention of N deposition and a greater role of synergy between N deposition and rising atmospheric CO2 as a mechanism governing increases in temperate forest primary production over the 20th century. Overall, testing models with both the response to gradual increases in N inputs over decades (N deposition) and N pulse additions of N over multiple years (N fertilization) allows for greater understanding of the mechanisms governing C-N coupling. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21994066','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21994066">Mild neurotrauma indicates a range-specific pressure response to low level shock wave exposure.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Vandevord, Pamela J; Bolander, Richard; Sajja, Venkata Siva Sai Sujith; Hay, Kathryn; Bir, Cynthia A 2012-01-01 Identifying the level of overpressure required to create physiological deficits is vital to advance prevention, diagnostic, and treatment strategies for individuals exposed to blasts. In this study, a rodent model of primary blast neurotrauma was employed to determine the pressure at which acute neurological alterations occurred. Rats were exposed to a single low intensity shock wave at a pressure of 0, 97, 117, or 153 kPa. Following exposure, rats were assessed for acute cognitive alterations using the Morris water maze and motor dysfunction using the horizontal ladder test. Subsequently, histological analyses of three brain regions (primary motor cortex, the hippocampal dentate gyrus region, and the posteromedial cortical amygdala) were conducted. Histological parameters included measuring the levels of glial fibrillary acidic protein (GFAP) to identify astrocyte activation, cleaved caspase-3 for early apoptosis identification and Fluoro-Jade B (FJB) which labels degenerating neurons within the brain tissue. The results demonstrated that an exposure to a single 117 kPa shock wave revealed a significant change in overall neurological deficits when compared to controls and the other pressures. The animals showed significant alterations in water maze parameters and a histological increase in the number of GFAP, caspase-3, and FJB-positive cells. It is suggested that when exposed to a low level shock wave, there may be a biomechanical response elicited by a specific pressure range which can cause low level neurological deficits within the rat. These data indicate that neurotrauma induced from a shock wave may lead to cognitive deficits in short-term learning and memory of rats. Additional histological evidence supports significant and diffuse glial activation and cellular damage. Further investigation into the biomechanical aspects of shock wave exposure is required to elucidate this pressure range-specific phenomenon. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2009JGRB..114.7205L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2009JGRB..114.7205L">Effective pressure law for permeability of E-bei sandstones</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Li, M.; Bernabé, Y.; Xiao, W.-I.; Chen, Z.-Y.; Liu, Z.-Q. 2009-07-01 Laboratory experiments were conducted to determine the effective pressure law for permeability of tight sandstone rocks from the E-bei gas reservoir, China. The permeability k of five core samples was measured while cycling the confining pressure pc and fluid pressure pf. The permeability data were analyzed using the response-surface method, a statistical model-building approach yielding a representation of k in (pc, pf) space that can be used to determine the effective pressure law, i.e., peff = pc - κpf. The results show that the coefficient κ of the effective pressure law for permeability varies with confining pressure and fluid pressure as well as with the loading or unloading cycles (i.e., hysteresis effect). Moreover, κ took very small values in some of the samples, even possibly lower than the value of porosity, in contradiction with a well-accepted theoretical model. We also reanalyzed a previously published permeability data set on fissured crystalline rocks and found again that the κ varies with pc but did not observe κ values lower than 0.4, a value much larger than porosity. Analysis of the dependence of permeability on effective pressure suggests that the occurrence of low κ values may be linked to the high-pressure sensitivity of E-bei sandstones. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2903687','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2903687">Responses of mirror neurons in area F5 to hand and tool grasping observation</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Rochat, Magali J.; Caruana, Fausto; Jezzini, Ahmad; Escola, Ludovic; Intskirveli, Irakli; Grammont, Franck; Gallese, Vittorio; Rizzolatti, Giacomo 2010-01-01 Mirror neurons are a distinct class of neurons that discharge both during the execution of a motor act and during observation of the same or similar motor act performed by another individual. However, the extent to which mirror neurons coding a motor act with a specific goal (e.g., grasping) might also respond to the observation of a motor act having the same goal, but achieved with artificial effectors, is not yet established. In the present study, we addressed this issue by recording mirror neurons from the ventral premotor cortex (area F5) of two monkeys trained to grasp objects with pliers. Neuron activity was recorded during the observation and execution of grasping performed with the hand, with pliers and during observation of an experimenter spearing food with a stick. The results showed that virtually all neurons responding to the observation of hand grasping also responded to the observation of grasping with pliers and, many of them to the observation of spearing with a stick. However, the intensity and pattern of the response differed among conditions. Hand grasping observation determined the earliest and the strongest discharge, while pliers grasping and spearing observation triggered weaker responses at longer latencies. We conclude that F5 grasping mirror neurons respond to the observation of a family of stimuli leading to the same goal. However, the response pattern depends upon the similarity between the observed motor act and the one executed by the hand, the natural motor template. PMID:20577726 </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26113719','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26113719">HIGH-PRESSURE PHYSICS. Direct observation of an abrupt insulator-to-metal transition in dense liquid deuterium.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Knudson, M D; Desjarlais, M P; Becker, A; Lemke, R W; Cochrane, K R; Savage, M E; Bliss, D E; Mattsson, T R; Redmer, R 2015-06-26 Eighty years ago, it was proposed that solid hydrogen would become metallic at sufficiently high density. Despite numerous investigations, this transition has not yet been experimentally observed. More recently, there has been much interest in the analog of this predicted metallic transition in the dense liquid, due to its relevance to planetary science. Here, we show direct observation of an abrupt insulator-to-metal transition in dense liquid deuterium. Experimental determination of the location of this transition provides a much-needed benchmark for theory and may constrain the region of hydrogen-helium immiscibility and the boundary-layer pressure in standard models of the internal structure of gas-giant planets. Copyright © 2015, American Association for the Advancement of Science. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25546675','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25546675">Does the position or contact pressure of the stethoscope make any difference to clinical blood pressure measurements: an observational study.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Pan, Fan; Zheng, Dingchang; He, Peiyu; Murray, Alan 2014-12-01 This study aimed to investigate the effect of stethoscope position and contact pressure on auscultatory blood pressure (BP) measurement. Thirty healthy subjects were studied. Two identical stethoscopes (one under the cuff, the other outside the cuff) were used to simultaneously and digitally record 2 channels of Korotkoff sounds during linear cuff pressure deflation. For each subject, 3 measurements with different contact pressures (0, 50, and 100 mm Hg) on the stethoscope outside the cuff were each recorded at 3 repeat sessions. The Korotkoff sounds were replayed twice on separate days to each of 2 experienced listeners to determine systolic and diastolic BPs (SBP and DBP). Variance analysis was performed to study the measurement repeatability and the effect of stethoscope position and contact pressure on BPs. There was no significant BP difference between the 3 repeat sessions, between the 2 determinations from each listener, between the 2 listeners and between the 3 stethoscope contact pressures (all P > 0.06). There was no significant SBP difference between the 2 stethoscope positions at the 2 lower stethoscope pressures (P = 0.23 and 0.45), but there was a small (0.4 mm Hg, clinically unimportant) significant difference (P = 0.005) at the highest stethoscope pressure. The key result was that, DBP from the stethoscope under the cuff was significantly lower than that from outside the cuff by 2.8 mm Hg (P < 0.001, 95% confidence interval -3.5 to -2.1 mm Hg). Since it is known that the traditional Korotkoff sound method, with the stethoscope outside the cuff, tends to give a higher DBP than the true intra-arterial pressure, this study could suggest that the stethoscope position under the cuff, and closer to the arterial occlusion, might yield measurements closer to the actual invasive DBP. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22688018','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22688018">A flowing liquid test system for assessing the linearity and time-response of rapid fibre optic oxygen partial pressure sensors.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Chen, R; Hahn, C E W; Farmery, A D 2012-08-15 The development of a methodology for testing the time response, linearity and performance characteristics of ultra fast fibre optic oxygen sensors in the liquid phase is presented. Two standard medical paediatric oxygenators are arranged to provide two independent extracorporeal circuits. Flow from either circuit can be diverted over the sensor under test by means of a system of rapid cross-over solenoid valves exposing the sensor to an abrupt change in oxygen partial pressure, P O2. The system is also capable of testing the oxygen sensor responses to changes in temperature, carbon dioxide partial pressure P CO2 and pH in situ. Results are presented for a miniature fibre optic oxygen sensor constructed in-house with a response time ≈ 50 ms and a commercial fibre optic sensor (Ocean Optics Foxy), when tested in flowing saline and stored blood. Copyright © 2012 Elsevier B.V. All rights reserved. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/1373769-high-pressure-structural-response-insensitive-energetic-crystal-dihydroxylammonium-bistetrazole-diolate-tkx','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/1373769-high-pressure-structural-response-insensitive-energetic-crystal-dihydroxylammonium-bistetrazole-diolate-tkx">High-Pressure Structural Response of an Insensitive Energetic Crystal: Dihydroxylammonium 5,5'-Bistetrazole-1,1'-diolate (TKX-50)</a> <a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a> Dreger, Zbigniew A.; Stash, Adam I.; Yu, Zhi-Gang 2017-03-06 The structural response of a novel, insensitive energetic crystal—dihydroxylammonium 5,5'-bistetrazole-1,1'-diolate (TKX-50)—was examined under high pressure. Using synchrotron single-crystal X-ray diffraction measurements, details of molecular, intermolecular, and crystal changes were determined to ~10 GPa to understand its structural stability. The experimental results showed that TKX-50 exhibits highly anisotropic compression and significantly lower volume compressibility than currently known energetic crystals. These results are found to be in general agreement with our previous predictions from the DFT calculations. Additionally, the experimental data revealed anomalous compression—an expansion of the unit cell along the a axis (negative linear compressibility, NLC) upon compression to ~3 GPa.more » The structural analyses demonstrated that this unusual effect, the first such observation in an energetic crystal, is a consequence of the highly anisotropic response of 3D motifs, comprised of two parallel anions [(C 2N 8O 2) 2–] linked with two cations [(NH 3OH) +] through four strong hydrogen bonds. The present results demonstrate that the structural stability of TKX-50 is controlled by the strong and highly anisotropic intermolecular interactions, and these may contribute to its shock insensitivity.« less </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1346981','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1346981">High-pressure structural response of an insensitive energetic crystal: Dihydroxylammonium 5,5'-bistetrazole-1,1'-diolate (TKX-50)</a> <a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a> Dreger, Zbigniew A.; Stash, Adam I.; Yu, Zhi -Gang The structural response of a novel, insensitive energetic crystal—dihydroxylammonium 5,5'-bistetrazole-1,1'-diolate (TKX-50)—was examined under high pressure. Using synchrotron single-crystal X-ray diffraction measurements, details of molecular, intermolecular, and crystal changes were determined to ~10 GPa to understand its structural stability. The experimental results showed that TKX-50 exhibits highly anisotropic compression and significantly lower volume compressibility than currently known energetic crystals. These results are found to be in general agreement with our previous predictions from the DFT calculations. Additionally, the experimental data revealed anomalous compression—an expansion of the unit cell along the a axis (negative linear compressibility, NLC) upon compression to ~3 GPa.more » The structural analyses demonstrated that this unusual effect, the first such observation in an energetic crystal, is a consequence of the highly anisotropic response of 3D motifs, comprised of two parallel anions [(C 2N 8O 2) 2–] linked with two cations [(NH 3OH) +] through four strong hydrogen bonds. Finally, the present results demonstrate that the structural stability of TKX-50 is controlled by the strong and highly anisotropic intermolecular interactions, and these may contribute to its shock insensitivity.« less </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1346981-high-pressure-structural-response-insensitive-energetic-crystal-dihydroxylammonium-bistetrazole-diolate-tkx','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1346981-high-pressure-structural-response-insensitive-energetic-crystal-dihydroxylammonium-bistetrazole-diolate-tkx">High-pressure structural response of an insensitive energetic crystal: Dihydroxylammonium 5,5'-bistetrazole-1,1'-diolate (TKX-50)</a> <a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a> Dreger, Zbigniew A.; Stash, Adam I.; Yu, Zhi -Gang; ... 2017-02-28 The structural response of a novel, insensitive energetic crystal—dihydroxylammonium 5,5'-bistetrazole-1,1'-diolate (TKX-50)—was examined under high pressure. Using synchrotron single-crystal X-ray diffraction measurements, details of molecular, intermolecular, and crystal changes were determined to ~10 GPa to understand its structural stability. The experimental results showed that TKX-50 exhibits highly anisotropic compression and significantly lower volume compressibility than currently known energetic crystals. These results are found to be in general agreement with our previous predictions from the DFT calculations. Additionally, the experimental data revealed anomalous compression—an expansion of the unit cell along the a axis (negative linear compressibility, NLC) upon compression to ~3 GPa.more » The structural analyses demonstrated that this unusual effect, the first such observation in an energetic crystal, is a consequence of the highly anisotropic response of 3D motifs, comprised of two parallel anions [(C 2N 8O 2) 2–] linked with two cations [(NH 3OH) +] through four strong hydrogen bonds. Finally, the present results demonstrate that the structural stability of TKX-50 is controlled by the strong and highly anisotropic intermolecular interactions, and these may contribute to its shock insensitivity.« less </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26374907','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26374907">Response of Preterm Infants to 2 Noninvasive Ventilatory Support Systems: Nasal CPAP and Nasal Intermittent Positive-Pressure Ventilation.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Silveira, Carmen Salum Thomé; Leonardi, Kamila Maia; Melo, Ana Paula Carvalho Freire; Zaia, José Eduardo; Brunherotti, Marisa Afonso Andrade 2015-12-01 Noninvasive ventilation (NIV) in preterm infants is currently applied using intermittent positive pressure (2 positive-pressure levels) or in a conventional manner (one pressure level). However, there are no studies in the literature comparing the chances of failure of these NIV methods. The aim of this study was to evaluate the occurrence of failure of 2 noninvasive ventilatory support systems in preterm neonates over a period of 48 h. A randomized, prospective, clinical study was conducted on 80 newborns (gestational age < 37 weeks, birthweight < 2,500 g). The infants were randomized into 2 groups: 40 infants were treated with nasal CPAP and 40 infants with nasal intermittent positive-pressure ventilation (NIPPV). The occurrence of apnea, progression of respiratory distress, nose bleeding, and agitation was defined as ventilation failure. The need for intubation and re-intubation after failure was also observed. There were no significant differences in birth characteristics between groups. Ventilatory support failure was observed in 25 (62.5%) newborns treated with nasal CPAP and in 12 (30%) newborns treated with NIPPV, indicating an association between NIV failure and the absence of intermittent positive pressure (odds ratio [OR] 1.22, P < .05). Apnea (32.5%) was the main reason for nasal CPAP failure. After failure, 25% (OR 0.33) of the newborns receiving nasal CPAP and 12.5% (OR 0.14) receiving NIPPV required invasive mechanical ventilation. Ventilatory support failure was significantly more frequent when nasal CPAP was used. Copyright © 2015 by Daedalus Enterprises. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1999IJBm...43...31D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1999IJBm...43...31D">The effects of extra-low-frequency atmospheric pressure oscillations on human mental activity</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Delyukov, A. A.; Didyk, L. Slight atmospheric pressure oscillations (APO) in the extra-low-frequency range below 0.1 Hz, which frequently occur naturally, can influence human mental activity. This phenomenon has been observed in experiments with a group of 12 healthy volunteers exposed to experimentally created APO with amplitudes 30-50 Pa in the frequency band 0.011-0.17 Hz. Exposure of the subjects to APO for 15-30 min caused significant changes in attention and short-term memory functions, performance rate, and mental processing flexibility. The character of the response depended on the APO frequency and coherence. Periodic APO promoted purposeful mental activity, accompanied by an increase in breath-holding duration and a slower heart rate. On the other hand, quasi-chaotic APO, similar to the natural perturbations of atmospheric pressure, disrupted mental activity. These observations suggest that APO could be partly responsible for meteorosensitivity in humans. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22464162','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22464162">Brachial cuff measurements of blood pressure during passive leg raising for fluid responsiveness prediction.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Lakhal, K; Ehrmann, S; Benzekri-Lefèvre, D; Runge, I; Legras, A; Dequin, P-F; Mercier, E; Wolff, M; Régnier, B; Boulain, T 2012-05-01 The passive leg raising maneuver (PLR) for fluid responsiveness testing relies on cardiac output (CO) measurements or invasive measurements of arterial pressure (AP) whereas the initial hemodynamic management during shock is often based solely on brachial cuff measurements. We assessed PLR-induced changes in noninvasive oscillometric readings to predict fluid responsiveness. Multicentre interventional study. In ICU sedated patients with circulatory failure, AP (invasive and noninvasive readings) and CO measurements were performed before, during PLR (trunk supine, not modified) and after 500-mL volume expansion. Areas under the ROC curves (AUC) were determined for fluid responsiveness (>10% volume expansion-induced increase in CO) prediction. In 112 patients (19% with arrhythmia), changes in noninvasive systolic AP during PLR (noninvasiveΔ(PLR)SAP) only predicted fluid responsiveness (cutoff 17%, n=21, positive likelihood ratio [LR] of 26 [18-38]), not unresponsiveness. If PLR-induced change in central venous pressure (CVP) was at least of 2 mm Hg (n=60), suggesting that PLR succeeded in altering cardiac preload, noninvasiveΔ(PLR)SAP performance was good: AUC of 0.94 [0.85-0.98], positive and negative LRs of 5.7 [4.6-6.8] and 0.07 [0.009-0.5], respectively, for a cutoff of 9%. Of note, invasive AP-derived indices did not outperform noninvasiveΔ(PLR)SAP. Regardless of CVP (i.e., during "blind PLR"), noninvasiveΔ(PLR)SAP more than 17% reliably identified fluid responders. During "CVP-guided PLR", in case of sufficient change in CVP, noninvasiveΔ(PLR)SAP performed better (cutoff of 9%). These findings, in sedated patients who had already undergone volume expansion and/or catecholamines, have to be verified during the early phase of circulatory failure (before an arterial line and/or a CO measuring device is placed). Copyright © 2012 Société française d’anesthésie et de réanimation (Sfar). Published by Elsevier SAS. All rights reserved. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24072460','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24072460">Pressures, flow, and brain oxygenation during plateau waves of intracranial pressure.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Dias, Celeste; Maia, Isabel; Cerejo, António; Varsos, Georgios; Smielewski, Peter; Paiva, José-Artur; Czosnyka, Marek 2014-08-01 Plateau waves are common in traumatic brain injury. They constitute abrupt increases of intracranial pressure (ICP) above 40 mmHg associated with a decrease in cerebral perfusion pressure (CPP). The aim of this study was to describe plateau waves characteristics with multimodal brain monitoring in head injured patients admitted in neurocritical care. Prospective observational study in 18 multiple trauma patients with head injury admitted to Neurocritical Care Unit of Hospital Sao Joao in Porto. Multimodal systemic and brain monitoring of primary variables [heart rate, arterial blood pressure, ICP, CPP, pulse amplitude, end tidal CO₂, brain temperature, brain tissue oxygenation pressure, cerebral oximetry (CO) with transcutaneous near-infrared spectroscopy and cerebral blood flow (CBF)] and secondary variables related to cerebral compensatory reserve and cerebrovascular reactivity were supported by dedicated software ICM+ ( www.neurosurg.cam.ac.uk/icmplus) . The compiled data were analyzed in patients who developed plateau waves. In this study we identified 59 plateau waves that occurred in 44% of the patients (8/18). During plateau waves CBF, cerebrovascular resistance, CO, and brain tissue oxygenation decreased. The duration and magnitude of plateau waves were greater in patients with working cerebrovascular reactivity. After the end of plateau wave, a hyperemic response was recorded in 64% of cases with increase in CBF and brain oxygenation. The magnitude of hyperemia was associated with better autoregulation status and low oxygenation levels at baseline. Multimodal brain monitoring facilitates identification and understanding of intrinsic vascular brain phenomenon, such as plateau waves, and may help the adequate management of acute head injury at bed side. </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active">24</li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div id="page_25" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active">25</li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="481"> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016AGUFM.A54F..01N','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016AGUFM.A54F..01N">Further Studies of Observational Undersampling of the Surface Wind and Pressure Fields in the Hurricane Inner-Core</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Nolan, D. S.; Klotz, B. 2016-12-01 Obtaining the best estimate of tropical cyclone (TC) intensity is vital for operational forecasting centers to produce accurate forecasts and to issue appropriate warnings. Aircraft data traditionally provide the most reliable information about the TC inner core and surrounding environment, but sampling strategies and observing platforms associated with reconnaissance aircraft have inherent deficiencies that contribute to the uncertainty of the intensity estimate. One such instrument, the stepped frequency microwave radiometer (SFMR) on the NOAA WP-3D aircraft, provides surface wind speeds along the aircraft flight track. However, the standard "figure-4" flight pattern substantially limits the azimuthal coverage of the eyewall, such that the chance of observing the true peak wind speeds is actually quite small. By simulating flights through a high-resolution simulation of Hurricane Isabel (2003), a previous study found that the 1-minute mean (maximum) SFMR winds underestimate a 6-hour running mean maximum wind (i.e. best track) by 7.5-10%. This project applies the same methodology to a suite of hurricane simulations with even higher resolution and more sophisticated physical parameterizations. These include the hurricane nature run of Nolan et al. (2013), the second hurricane nature run, a simulation of Hurricane Bill (2009), and additional idealized simulations. For the nature run cases, we find that the mean underestimate of the best-track estimate is 12-15%, considerably higher than determined from the Isabel simulation, while the other cases are similar to the previous result. Comparisons of the various cases indicates that the primary factors that lead to greater undersampling rates are storm size and storm asymmetry. Minimum surface pressure is also frequently estimated from pressures reported by dropsondes released into the eye, with a standard correction of 1 hPa per 10 knots of wind at the time of "splash." Statistics from thousands of simulated splash </li> <li> <a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=groups+AND+blood&pg=4&id=EJ990847','ERIC'); return false;" href="https://eric.ed.gov/?q=groups+AND+blood&pg=4&id=EJ990847">Social Support Is Associated with Blood Pressure Responses in Parents Caring for Children with Developmental Disabilities</a> <a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a> Gallagher, Stephen; Whiteley, Jenny 2012-01-01 The present study tested whether parents caring for children with developmental disabilities would have higher blood pressure compared to parents of typically developing children (controls). It also examined the psychosocial factors underlying this observation. Thirty-five parents of children with developmental disability and thirty controls… </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29775998','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29775998">High pressure Raman study of type-I collagen.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Paschou, Amalia Maria; Katsikini, Maria; Christofilos, Dimitrios; Arvanitidis, John; Ves, Sotirios 2018-05-18 The high pressure response of type-I collagen from bovine Achilles tendon is investigated with micro-Raman spectroscopy. Fluorinert ™ and methanol-ethanol mixtures were used as pressure transmitting media (PTM) in a diamond anvil cell. The Raman spectrum of collagen is dominated by three bands centred at approximately 1450, 1660 and 2930 cm -1 , attributed to C-H deformation, C=O stretching of the peptide bond (amide-I band) and C-H stretching modes, respectively. Upon pressure increase, using Fluorinert ™ as PTM, a shift towards higher frequencies of the C-H stretching and deformation peaks is observed. Contrary, the amide-I band peaks are shifted to lower frequencies with moderate pressure slopes. On the other hand, by using the alcohol mixture as PTM, the amide-I band exhibits more pronounced C=O bond softening, deduced from the shift to lower frequencies, suggesting a strengthening of the hydrogen bonds between glycine and proline residues of different collagen chains due to the presence of the polar alcohol molecules. Furthermore, some of the peaks exhibit abrupt changes in their pressure slopes at approximately 2 GPa, implying a variation in the compressibility of the collagen fibres. This could be attributed to a pitch change from 10/3 to 7/2, sliding of the tropocollagen molecules, twisting variation at the molecular level and/or elimination of the D-gaps induced by kink compression. All spectral changes are reversible upon pressure release, which indicates that denaturation has not taken place. Finally, a minor lipid phase contamination was detected in some sample spots. Its pressure response is also monitored. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018JGRA..123.2974O','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018JGRA..123.2974O">Modeling Study of the Geospace System Response to the Solar Wind Dynamic Pressure Enhancement on 17 March 2015</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Ozturk, D. S.; Zou, S.; Ridley, A. J.; Slavin, J. A. 2018-04-01 The global magnetosphere-ionosphere-thermosphere system is intrinsically coupled and susceptible to external drivers such as solar wind dynamic pressure enhancements. In order to understand the large-scale dynamic processes in the magnetosphere-ionosphere-thermosphere system due to the compression from the solar wind, the 17 March 2015 sudden commencement was studied in detail using global numerical models. This storm was one of the most geoeffective events of the solar cycle 24 with a minimum Dst of -222 nT. The Wind spacecraft recorded a 10-nPa increment in the solar wind dynamic pressure, while the interplanetary magnetic field BZ became further northward. The University of Michigan Block-Adaptive-Tree Solar wind Roe-type Upwind Scheme global magnetohydrodynamic code was utilized to study the generation and propagation of perturbations associated with the compression of the magnetosphere system. In addition, the high-resolution electric potential and auroral power output from the magnetohydrodynamic model was used to drive the global ionosphere-thermosphere model to investigate the ionosphere-thermosphere system response to pressure enhancement. During the compression, the electric potentials and convection patterns in the polar ionosphere were significantly altered when the preliminary impulse and main impulse field-aligned currents moved from dayside to nightside. As a result of enhanced frictional heating, plasma and neutral temperatures increased at the locations where the flow speeds were enhanced, whereas the electron density dropped at these locations. In particular, the region between the preliminary impulse and main impulse field-aligned currents experienced the most significant heating with 1000-K ion temperature increase and 20-K neutral temperature increase within 2 min. Comparison of the simulation results with the Poker Flat Incoherent Scatter Radar observations showed reasonable agreements despite underestimated magnitudes. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25353481','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25353481">Water under inner pressure: a dielectric spectroscopy study.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Angulo-Sherman, Abril; Mercado-Uribe, Hilda 2014-02-01 Water is the most studied substance on Earth. However, it is not completely understood why its structural and dynamical properties give rise to some anomalous behaviors. Some of them emerge when experiments at low temperatures and/or high pressures are performed. Here we report dielectric measurements on cold water under macroscopically constrained conditions, i.e., water in a large container at constant volume that cannot freeze below the melting point. The inner pressure in these conditions shifts the α relaxation peak to similar frequencies as seen in ice Ih. At 267 K we observe a peculiar response possibly due to the Grotthuss mechanism. At 251 K (the triple point) ice III forms. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=atmospheric+AND+pressure&pg=4&id=EJ512571','ERIC'); return false;" href="https://eric.ed.gov/?q=atmospheric+AND+pressure&pg=4&id=EJ512571">Atmospheric Pressure Indicator.</a> <a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a> Salzsieder, John C. 1995-01-01 Discusses observable phenomena related to air pressure. Describes a simple, unobtrusive, semiquantitative device to monitor the changes in air pressure that are associated with altitude, using a soft-drink bottle and a balloon. (JRH) </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/18216577','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/18216577">Rabbit cornea microstructure response to changes in intraocular pressure visualized by using nonlinear optical microscopy.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Wu, Qiaofeng; Yeh, Alvin T 2008-02-01 To characterize the microstructural response of the rabbit cornea to changes in intraocular pressure (IOP) by using nonlinear optical microscopy (NLOM). Isolated rabbit corneas were mounted on an artificial anterior chamber in series with a manometer and were hydrostatically pressurized by a reservoir. The chamber was mounted on an upright microscope stage of a custom-built NLOM system for corneal imaging without using exogenous stains or dyes. Second harmonic generation in collagen was used to image through the full thickness of the central corneal stroma at IOPs between 5 and 20 mm Hg. Microstructural morphology changes as a function of IOP were used to characterize the depth-dependent response of the central cornea. Regional collagen lamellae architecture through the full thickness of the stroma was specifically imaged as a function of IOP. Hypotensive corneas showed gaps between lamellar structures that decreased in size with increasing IOP. These morphologic features appear to result from interwoven lamellae oriented along the anterior-posterior axis and parallel to the cornea surface. They appear throughout the full thickness and disappear with tension in the anterior but persist in the posterior central cornea, even at hypertensive IOP. NLOM reveals interwoven collagen lamellae sheets through the full thickness of the rabbit central cornea oriented along the anterior-posterior axis and parallel to the surface. The nondestructive nature of NLOM allows 3-dimensional imaging of stromal architecture as a function of IOP in situ. Collagen morphologic features were used as an indirect measure of depth-dependent mechanical response to changes in IOP. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/2743621','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/2743621">Renal sympathetic nerve activity measured by norepinephrine spillover rate in response to changes in blood pressure in conscious rabbits.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Sano, N; Way, D; McGrath, B P 1989-04-01 1. Renal sympathetic nerve activity (RSNA) in response to changes in mean arterial pressure (MAP) was examined by measuring renal norepinephrine (NE) spillover rate in conscious rabbits. 2. A chronic renal vein catheter was implanted for sampling renal venous blood without stress in conscious animals. 3. RSNA estimated by renal NE spillover rate significantly increased in response to moderate falls in MAP produced by sodium nitroprusside (SNP) infusion and decreased in response to moderate rises in MAP produced by phenylephrine (PE) infusion. 4. The NE spillover method is sufficiently sensitive to detect responses of RSNA to physiological stimuli in conscious rabbits. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018MeScT..29d5301H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018MeScT..29d5301H">A practical model for pressure probe system response estimation (with review of existing models)</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Hall, B. F.; Povey, T. 2018-04-01 The accurate estimation of the unsteady response (bandwidth) of pneumatic pressure probe systems (probe, line and transducer volume) is a common practical problem encountered in the design of aerodynamic experiments. Understanding the bandwidth of the probe system is necessary to capture unsteady flow features accurately. Where traversing probes are used, the desired traverse speed and spatial gradients in the flow dictate the minimum probe system bandwidth required to resolve the flow. Existing approaches for bandwidth estimation are either complex or inaccurate in implementation, so probes are often designed based on experience. Where probe system bandwidth is characterized, it is often done experimentally, requiring careful experimental set-up and analysis. There is a need for a relatively simple but accurate model for estimation of probe system bandwidth. A new model is presented for the accurate estimation of pressure probe bandwidth for simple probes commonly used in wind tunnel environments; experimental validation is provided. An additional, simple graphical method for air is included for convenience. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16658260','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16658260">Ethylene: Response of Fruit Dehiscence to CO(2) and Reduced Pressure.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Lipe, J A; Morgan, P W 1972-12-01 These studies were conducted to determine whether ethylene serves as a natural regulator of fruit wall dehiscence, a major visible feature of ripening in some fruits. We employed treatments to inhibit ethylene action or remove ethylene and observed their effect on fruit dehiscence. CO(2) (13%), a competitive inhibitor of ethylene action in many systems, readily delayed dehiscence of detached fruits of cotton (Gossypium hirsutum L.), pecan (Carya illinoensis [Wang.] K. Koch), and okra (Hibiscus esculentus L.). The CO(2) effect was duplicated by placing fruits under reduced pressure (200 millimeters mercury), to promote the escape of ethylene from the tissue. Dehiscence of detached fruits of these species as well as attached cotton fruits was delayed. The delay of dehiscence of cotton and okra by both treatments was achieved with fruit harvested at intervals from shortly after anthesis until shortly before natural dehiscence. Pecan fruits would not dehisce until approximately 1 month before natural dehiscence, and during that time, CO(2) and reduced pressure delayed dehiscence. CO(2) and ethylene were competitive in their effects on cotton fruit dehiscence. All of the results are compatible with a hypothetical role of ethylene as a natural regulator of dehiscence, a dominant aspect of ripening of cotton, pecan, and some other fruits. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23554176','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23554176">Time pressure undermines performance more under avoidance than approach motivation.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Roskes, Marieke; Elliot, Andrew J; Nijstad, Bernard A; De Dreu, Carsten K W 2013-06-01 Four experiments were designed to test the hypothesis that performance is particularly undermined by time pressure when people are avoidance motivated. The results supported this hypothesis across three different types of tasks, including those well suited and those ill suited to the type of information processing evoked by avoidance motivation. We did not find evidence that stress-related emotions were responsible for the observed effect. Avoidance motivation is certainly necessary and valuable in the self-regulation of everyday behavior. However, our results suggest that given its nature and implications, it seems best that avoidance motivation is avoided in situations that involve (time) pressure. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=policy+AND+Venezuela&pg=2&id=ED536023','ERIC'); return false;" href="https://eric.ed.gov/?q=policy+AND+Venezuela&pg=2&id=ED536023">Journal Publication in Chile, Colombia, and Venezuela: University Responses to Global, Regional, and National Pressures and Trends</a> <a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a> Delgado, Jorge Enrique 2011-01-01 Background. This project was motivated by the impressive growth that scholarly/scientific journals in Latin America have shown in recent decades. That advance is attributed to global, regional, and national pressures and trends, as well as a response to obstacles that scholars/researchers from the region face to be published in prestigious… </li> <li> <a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19830000200&hterms=spool&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Dspool','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19830000200&hterms=spool&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Dspool">Spool-Valve Pressure-Difference Regulator</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Grasso, A. P. 1983-01-01 Valves maintain preset pressure difference between gas flows. Two spool valves connected by shaft move back and forth in response to changes in pressure in oxygen and hydrogen chambers. Spool-valve assembly acts to restore pressures to preset difference. By eliminating diaphragms, pressure exerted directly on external end of spool valve; however, forces and therefore sensitivity of assembly are reduced. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://pubs.er.usgs.gov/publication/70191542','USGSPUBS'); return false;" href="https://pubs.er.usgs.gov/publication/70191542">Influence of pore pressure change on coseismic volumetric strain</a> <a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a> Wang, Chi-Yuen; Barbour, Andrew J. 2017-01-01 Coseismic strain is fundamentally important for understanding crustal response to changes of stress after earthquakes. The elastic dislocation model has been widely applied to interpreting observed shear deformation caused by earthquakes. The application of the same theory to interpreting volumetric strain, however, has met with difficulty, especially in the far field of earthquakes. Predicted volumetric strain with dislocation model often differs substantially, and sometimes of opposite signs, from observed coseismic volumetric strains. The disagreement suggests that some processes unaccounted for by the dislocation model may occur during earthquakes. Several hypotheses have been suggested, but none have been tested quantitatively. In this paper we first examine published data to highlight the difference between the measured and calculated static coseismic volumetric strains; we then use these data to provide quantitative test of the model that the disagreement may be explained by the change of pore pressure in the shallow crust. The test allows us to conclude that coseismic change of pore pressure may be an important mechanism for coseismic crustal strain and, in the far field, may even be the dominant mechanism. Thus in the interpretation of observed coseismic crustal strain, one needs to account not only for the elastic strain due to fault rupture but also for the strain due to coseismic change of pore pressure. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1765307','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1765307">Heading in football. Part 3: Effect of ball properties on head response</a> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a> Shewchenko, N; Withnall, C; Keown, M; Gittens, R; Dvorak, J 2005-01-01 Objectives: Head impacts from footballs are an essential part of the game but have been implicated in mild and acute neuropsychological impairment. Ball characteristics have been noted in literature to affect the impact response of the head; however, the biomechanics are not well understood. The present study determined whether ball mass, pressure, and construction characteristics help reduce head and neck can impact response. Methods: Head responses under ball impact (6–7 m/s) were measured with a biofidelic numerical human model and controlled human subject trials (n = 3). Three ball masses and four ball pressures were investigated for frontal heading. Further, the effect of ball construction in wet/dry conditions was studied with the numerical model. The dynamic ball characteristics were determined experimentally. Head linear and angular accelerations were measured and compared with injury assessment functions comprising peak values and head impact power. Neck responses were assessed with the numerical model. Results: Ball mass reductions up to 35% resulted in decreased head responses up to 23–35% for the numerical and subject trials. Similar decreases in neck axial and shear responses were observed. Ball pressure reductions of 50% resulted in head and neck response reductions up to 10–31% for the subject trials and numerical model. Head response reductions up to 15% were observed between different ball constructions. The wet condition generally resulted in greater head and neck responses of up to 20%. Conclusion: Ball mass, pressure, and construction can reduce the impact severity to the head and neck. It is foreseeable that the benefits can be extended to players of all ages and skill levels. PMID:16046354 </li> <li> <a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20160005719','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20160005719">Hydraulic High Pressure Valve Controller Using the In-Situ Pressure Difference</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Badescu, Mircea (Inventor); Bar-Cohen, Yoseph (Inventor); Hall, Jeffery L. (Inventor); Sherrit, Stewart (Inventor); Bao, Xiaoqi (Inventor) 2016-01-01 A hydraulic valve controller that uses an existing pressure differential as some or all of the power source for valve operation. In a high pressure environment, such as downhole in an oil or gas well, the pressure differential between the inside of a pipe and the outside of the pipe may be adequately large to drive a linear slide valve. The valve is operated hydraulically by a piston in a bore. When a higher pressure is applied to one end of the bore and a lower pressure to the other end, the piston moves in response to the pressure differential and drives a valve attached to it. If the pressure differential is too small to drive the piston at a sufficiently high speed, a pump is provided to generate a larger pressure differential to be applied. The apparatus is conveniently constructed using multiport valves, which can be rotary valves. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19890005711','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19890005711">Shock tube investigation of dynamic response of pressure transducers for validation of rotor performance measurements</a> <a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a> Bershader, Daniel 1988-01-01 For some time now, NASA has had a program under way to aid in the validation of rotor performance and acoustics codes associated with the UH-60 rotary-wing aircraft; and to correlate results of such studies with those obtained from investigations of other selected aircraft rotor performance. A central feature of these studies concerns the dynamic measurement of surface pressure at various locations up to frequencies of 25 KHz. For this purpose, fast-response gauges of the Kulite type are employed. The latter need to be buried in the rotor; they record surface pressures which are transmitted by a pipette connected to the gauge. The other end of the pipette is cut flush with the surface. In certain locations, the pipette configuration includes a rather sharp right-angle bend. The natural question has arisen in this connection: In what way are the pipettes modifying the signals received at the rotor surface and subsequently transmitted to the sensitive Kulite transducer element. The basic details and results of the program performed and recently completed in the High Pressure Shock Tube Laboratory of the Department of Aeronautics and Astronautics at Stanford University are given. </li> <li> <a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018JGRB..123.1072K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018JGRB..123.1072K">Changes in Physical Properties of the Nankai Trough Megasplay Fault Induced by Earthquakes, Detected by Continuous Pressure Monitoring</a> <a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a> Kinoshita, C.; Saffer, D.; Kopf, A.; Roesner, A.; Wallace, L. M.; Araki, E.; Kimura, T.; Machida, Y.; Kobayashi, R.; Davis, E.; Toczko, S.; Carr, S. 2018-02-01 One primary objective of Integrated Ocean Drilling Program Expedition 365, conducted as part of the Nankai Trough Seismogenic Zone Experiment, was to recover a temporary observatory emplaced to monitor formation pore fluid pressure and temperature within a splay fault in the Nankai subduction zone offshore SW Honshu, Japan. Here we use a 5.3 year time series of formation pore fluid pressure, and in particular the response to ocean tidal loading, to evaluate changes in pore pressure and formation and fluid elastic properties induced by earthquakes. Our analysis reveals 31 earthquake-induced perturbations. These are dominantly characterized by small transient increases in pressure (28 events) and decreases in ocean tidal loading efficiency (14 events) that reflect changes to formation or fluid compressibility. The observed perturbations follow a magnitude-distance threshold similar to that reported for earthquake-driven hydrological effects in other settings. To explore the mechanisms that cause these changes, we evaluate the expected static and dynamic strains from each earthquake. The expected static strains are too small to explain the observed pressure changes. In contrast, estimated dynamic strains correlate with the magnitude of changes in both pressure and loading efficiency. We propose potential mechanism for the changes and subsequent recovery, which is exsolution of dissolved gas in interstitial fluids in response to shaking. </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.fs.usda.gov/treesearch/pubs/24780','TREESEARCH'); return false;" href="https://www.fs.usda.gov/treesearch/pubs/24780">Advective transport of CO2 in permeable media induced by atmospheric pressure fluctuations: 2. Observational evidence under snowpacks</a> <a target="_blank" href="http://www.fs.usda.gov/treesearch/">Treesearch</a> W. J. Massman; J. M. Frank 2006-01-01 Meadow and forest CO2 amounts sampled beneath an approximately meter deep (steady state) snowpack at a subalpine site in southern Rocky Mountains of Wyoming are observed to vary by nearly 200 ppm over periods ranging from 4 to 15 days. This work employs the model of periodic, pressure-induced, advective transport in permeable media developed in... </li> <li> <a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/18853700','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/18853700">Aerophagia and gastroesophageal reflux disease in patients using continuous positive airway pressure: a preliminary observation.</a> <a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a> Watson, Nathaniel F; Mystkowski, Sue K 2008-10-15 Aerophagia is a complication of continuous positive airway pressure (CPAP) therapy for sleep disordered breathing (SDB), whereupon air is forced into the stomach and bowel. Associated discomfort can result in CPAP discontinuation. We hypothesize that aerophagia is associated with gastroesophageal reflux disease (GERD) via mechanisms involving GERD related lower esophageal sphincter (LES) compromise. Twenty-two subjects with aerophagia and 22 controls, matched for age, gender, and body mass index, who were being treated with CPAP for SDB were compared in regard to clinical aspects of GERD, GERD associated habits, SDB severity as measured by polysomnography, and mean CPAP pressure. More subjects with aerophagia had symptoms of GERD (77.3% vs. 36.4%; p < 0.01) and were on GERD related medications (45.5% vs. 18.2%, p < 0.05) than controls. Regarding polysomnography, mean oxygen saturation percentages were lower in the aerophagia group than controls (95.0% vs. 96.5%, p < 0.05). No other differences were observed, including mean CPAP pressures. No one in the aerophagia group (vs. 27.3% of the control group) was a current tobacco user (p < 0.01). There was no difference in caffeine or alcohol use between the 2 groups. These results imply aerophagia is associated with GERD symptoms and GERD related medication use. This finding suggests a relationship between GERD related LES pathophysiology and the development of aerophagia in patients with SDB treated with CPAP. </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active">25</li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> </div> <div class="footer-extlink text-muted" style="margin-bottom:1rem; text-align:center;">Some links on this page may take you to non-federal websites. 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Sample records for observed pressure response