Training directionally selective motion pathways can significantly improve reading efficiency

NASA Astrophysics Data System (ADS)

Lawton, Teri

2004-06-01

This study examined whether perceptual learning at early levels of visual processing would facilitate learning at higher levels of processing. This was examined by determining whether training the motion pathways by practicing leftright movement discrimination, as found previously, would improve the reading skills of inefficient readers significantly more than another computer game, a word discrimination game, or the reading program offered by the school. This controlled validation study found that practicing left-right movement discrimination 5-10 minutes twice a week (rapidly) for 15 weeks doubled reading fluency, and significantly improved all reading skills by more than one grade level, whereas inefficient readers in the control groups barely improved on these reading skills. In contrast to previous studies of perceptual learning, these experiments show that perceptual learning of direction discrimination significantly improved reading skills determined at higher levels of cognitive processing, thereby being generalized to a new task. The deficits in reading performance and attentional focus experienced by the person who struggles when reading are suggested to result from an information overload, resulting from timing deficits in the direction-selectivity network proposed by Russell De Valois et al. (2000), that following practice on direction discrimination goes away. This study found that practicing direction discrimination rapidly transitions the inefficient 7-year-old reader to an efficient reader.

Scoring haemophilic arthropathy on X-rays: improving inter- and intra-observer reliability and agreement using a consensus atlas.

PubMed

Foppen, Wouter; van der Schaaf, Irene C; Beek, Frederik J A; Verkooijen, Helena M; Fischer, Kathelijn

2016-06-01

The radiological Pettersson score (PS) is widely applied for classification of arthropathy to evaluate costly haemophilia treatment. This study aims to assess and improve inter- and intra-observer reliability and agreement of the PS. Two series of X-rays (bilateral elbows, knees, and ankles) of 10 haemophilia patients (120 joints) with haemophilic arthropathy were scored by three observers according to the PS (maximum score 13/joint). Subsequently, (dis-)agreement in scoring was discussed until consensus. Example images were collected in an atlas. Thereafter, second series of 120 joints were scored using the atlas. One observer rescored the second series after three months. Reliability was assessed by intraclass correlation coefficients (ICC), agreement by limits of agreement (LoA). Median Pettersson score at joint level (PSjoint) of affected joints was 6 (interquartile range 3-9). Using the consensus atlas, inter-observer reliability of the PSjoint improved significantly from 0.94 (95 % confidence interval (CI) 0.91-0.96) to 0.97 (CI 0.96-0.98). LoA improved from ±1.7 to ±1.1 for the PSjoint. Therefore, true differences in arthropathy were differences in the PSjoint of >2 points. Intra-observer reliability of the PSjoint was 0.98 (CI 0.97-0.98), intra-observer LoA were ±0.9 points. Reliability and agreement of the PS improved by using a consensus atlas. • Reliability of the Pettersson score significantly improved using the consensus atlas. • The presented consensus atlas improved the agreement among observers. • The consensus atlas could be recommended to obtain a reproducible Pettersson score.

Kinematic and kinetic improvements associated with action observation facilitated learning of the power clean in Australian footballers.

PubMed

Sakadjian, Alex; Panchuk, Derek; Pearce, Alan J

2014-06-01

This study investigated the effectiveness of action observation (AO) on facilitating learning of the power clean technique (kinematics) compared with traditional strength coaching methods and whether improvements in performance (kinetics) were associated with an improvement in lifting technique. Fifteen subjects (age, 20.9 ± 2.3 years) with no experience in performing the power clean exercise attended 12 training and testing sessions over a 4-week period. Subjects were assigned to 2 matched groups, based on preintervention power clean performance and performed 3 sets of 5 repetitions of the power clean exercise at each training session. Subjects in the traditional coaching group (TC; n = 7) received the standard coaching feedback (verbal cues and physical practice), whereas subjects in the AO group (n = 8) received similar verbal coaching cues and physical practice but also observed a video of a skilled model before performing each set. Kinematic data were collected from video recordings of subjects who were fitted with joint center markings during testing, whereas kinetic data were collected from a weightlifting analyzer attached to the barbell. Subjects were tested before intervention, at the end of weeks 2 and 3, and at after intervention at the end of week 4. Faster improvements (3%) were observed in power clean technique with AO-facilitated learning in the first week and performance improvements (mean peak power of the subject's 15 repetitions) over time were significant (p < 0.001). In addition, performance improvement was significantly associated (R = 0.215) with technique improvements. In conclusion, AO combined with verbal coaching and physical practice of the power clean exercise resulted in significantly faster technique improvements and improvement in performance compared with traditional coaching methods.

Improving BeiDou precise orbit determination using observations of onboard MEO satellite receivers

NASA Astrophysics Data System (ADS)

Ge, Haibo; Li, Bofeng; Ge, Maorong; Shen, Yunzhong; Schuh, Harald

2017-12-01

In recent years, the precise orbit determination (POD) of the regional Chinese BeiDou Navigation Satellite System (BDS) has been a hot spot because of its special constellation consisting of five geostationary earth orbit (GEO) satellites and five inclined geosynchronous satellite orbit (IGSO) satellites besides four medium earth orbit (MEO) satellites since the end of 2012. GEO and IGSO satellites play an important role in regional BDS applications. However, this brings a great challenge to the POD, especially for the GEO satellites due to their geostationary orbiting. Though a number of studies have been carried out to improve the POD performance of GEO satellites, the result is still much worse than that of IGSO and MEO, particularly in the along-track direction. The major reason is that the geostationary characteristic of a GEO satellite results in a bad geometry with respect to the ground tracking network. In order to improve the tracking geometry of the GEO satellites, a possible strategy is to mount global navigation satellite system (GNSS) receivers on MEO satellites to collect the signals from GEO/IGSO GNSS satellites so as that these observations can be used to improve GEO/IGSO POD. We extended our POD software package to simulate all the related observations and to assimilate the MEO-onboard GNSS observations in orbit determination. Based on GPS and BDS constellations, simulated studies are undertaken for various tracking scenarios. The impact of the onboard GNSS observations is investigated carefully and presented in detail. The results show that MEO-onboard observations can significantly improve the orbit precision of GEO satellites from metres to decimetres, especially in the along-track direction. The POD results of IGSO satellites also benefit from the MEO-onboard data and the precision can be improved by more than 50% in 3D direction.

Significance of beating observed in earthquake responses of buildings

USGS Publications Warehouse

Çelebi, Mehmet; Ghahari, S. F.; Taciroglu, E.

2016-01-01

The beating phenomenon observed in the recorded responses of a tall building in Japan and another in the U.S. are examined in this paper. Beating is a periodic vibrational behavior caused by distinctive coupling between translational and torsional modes that typically have close frequencies. Beating is prominent in the prolonged resonant responses of lightly damped structures. Resonances caused by site effects also contribute to accentuating the beating effect. Spectral analyses and system identification techniques are used herein to quantify the periods and amplitudes of the beating effects from the strong motion recordings of the two buildings. Quantification of beating effects is a first step towards determining remedial actions to improve resilient building performance to strong earthquake induced shaking.

Significant and Sustained Reduction in Chemotherapy Errors Through Improvement Science.

PubMed

Weiss, Brian D; Scott, Melissa; Demmel, Kathleen; Kotagal, Uma R; Perentesis, John P; Walsh, Kathleen E

2017-04-01

A majority of children with cancer are now cured with highly complex chemotherapy regimens incorporating multiple drugs and demanding monitoring schedules. The risk for error is high, and errors can occur at any stage in the process, from order generation to pharmacy formulation to bedside drug administration. Our objective was to describe a program to eliminate errors in chemotherapy use among children. To increase reporting of chemotherapy errors, we supplemented the hospital reporting system with a new chemotherapy near-miss reporting system. After the model for improvement, we then implemented several interventions, including a daily chemotherapy huddle, improvements to the preparation and delivery of intravenous therapy, headphones for clinicians ordering chemotherapy, and standards for chemotherapy administration throughout the hospital. Twenty-two months into the project, we saw a centerline shift in our U chart of chemotherapy errors that reached the patient from a baseline rate of 3.8 to 1.9 per 1,000 doses. This shift has been sustained for > 4 years. In Poisson regression analyses, we found an initial increase in error rates, followed by a significant decline in errors after 16 months of improvement work ( P < .001). After the model for improvement, our improvement efforts were associated with significant reductions in chemotherapy errors that reached the patient. Key drivers for our success included error vigilance through a huddle, standardization, and minimization of interruptions during ordering.

Leveraging Disturbance Observer Based Torque Control for Improved Impedance Rendering with Series Elastic Actuators

NASA Technical Reports Server (NTRS)

Mehling, Joshua S.; Holley, James; O'Malley, Marcia K.

2015-01-01

The fidelity with which series elastic actuators (SEAs) render desired impedances is important. Numerous approaches to SEA impedance control have been developed under the premise that high-precision actuator torque control is a prerequisite. Indeed, the design of an inner torque compensator has a significant impact on actuator impedance rendering. The disturbance observer (DOB) based torque control implemented in NASA's Valkyrie robot is considered here and a mathematical model of this torque control, cascaded with an outer impedance compensator, is constructed. While previous work has examined the impact a disturbance observer has on torque control performance, little has been done regarding DOBs and impedance rendering accuracy. Both simulation and a series of experiments are used to demonstrate the significant improvements possible in an SEA's ability to render desired dynamic behaviors when utilizing a DOB. Actuator transparency at low impedances is improved, closed loop hysteresis is reduced, and the actuator's dynamic response to both commands and interaction torques more faithfully matches that of the desired model. All of this is achieved by leveraging DOB based control rather than increasing compensator gains, thus making improved SEA impedance control easier to achieve in practice.

Astronaut observations from lunar orbit and their geologic significance.

NASA Technical Reports Server (NTRS)

El-Baz, F.; Worden, A. M.; Brand, V. D.

1972-01-01

To supplement orbital photography and other remotely sensed data, visual observations were made of 15 lunar surface targets during Apollo mission 15. Among the significant results are (1) characterization of the floor material of Tsiolkovsky as no darker than the average (Eratosthenian) mare material, and interpretration of the lineated unit on the crater rim as a rock avalanche; (2) identification of layers on the wall of the crater Picard, which is probably volcanic in origin, (3) explanation of the ray-excluded zone of the crater Proclus as the result of structurally controlled ray shadowing; (4) observation of cinder cones in the Littrow area with dark haloes that probably are composed of pyroclastic deposits; and (5) recognition that the termini of numerous sinuous rilles in Oceanus Procellarum are flooded with younger mare materials that may have covered older terminal deposits.

Substantial Progress Yet Significant Opportunity for Improvement in Stroke Care in China.

PubMed

Li, Zixiao; Wang, Chunjuan; Zhao, Xingquan; Liu, Liping; Wang, Chunxue; Li, Hao; Shen, Haipeng; Liang, Li; Bettger, Janet; Yang, Qing; Wang, David; Wang, Anxin; Pan, Yuesong; Jiang, Yong; Yang, Xiaomeng; Zhang, Changqing; Fonarow, Gregg C; Schwamm, Lee H; Hu, Bo; Peterson, Eric D; Xian, Ying; Wang, Yilong; Wang, Yongjun

2016-11-01

Stroke is a leading cause of death in China. Yet the adherence to guideline-recommended ischemic stroke performance metrics in the past decade has been previously shown to be suboptimal. Since then, several nationwide stroke quality management initiatives have been conducted in China. We sought to determine whether adherence had improved since then. Data were obtained from the 2 phases of China National Stroke Registries, which included 131 hospitals (12 173 patients with acute ischemic stroke) in China National Stroke Registries phase 1 from 2007 to 2008 versus 219 hospitals (19 604 patients) in China National Stroke Registries phase 2 from 2012 to 2013. Multiple regression models were developed to evaluate the difference in adherence to performance measure between the 2 study periods. The overall quality of care has improved over time, as reflected by the higher composite score of 0.76 in 2012 to 2013 versus 0.63 in 2007 to 2008. Nine of 13 individual performance metrics improved. However, there were no significant improvements in the rates of intravenous thrombolytic therapy and anticoagulation for atrial fibrillation. After multivariate analysis, there remained a significant 1.17-fold (95% confidence interval, 1.14-1.21) increase in the odds of delivering evidence-based performance metrics in the more recent time periods versus older data. The performance metrics with the most significantly increased odds included stroke education, dysphagia screening, smoking cessation, and antithrombotics at discharge. Adherence to stroke performance metrics has increased over time, but significant opportunities remain for further improvement. Continuous stroke quality improvement program should be developed as a national priority in China. © 2016 American Heart Association, Inc.

Improve observation-based ground-level ozone spatial distribution by compositing satellite and surface observations: A simulation experiment

NASA Astrophysics Data System (ADS)

Zhang, Yuzhong; Wang, Yuhang; Crawford, James; Cheng, Ye; Li, Jianfeng

2018-05-01

Obtaining the full spatial coverage of daily surface ozone fields is challenging because of the sparsity of the surface monitoring network and the difficulty in direct satellite retrievals of surface ozone. We propose an indirect satellite retrieval framework to utilize the information from satellite-measured column densities of tropospheric NO2 and CH2O, which are sensitive to the lower troposphere, to derive surface ozone fields. The method is applicable to upcoming geostationary satellites with high-quality NO2 and CH2O measurements. To prove the concept, we conduct a simulation experiment using a 3-D chemical transport model for July 2011 over the eastern US. The results show that a second order regression using both NO2 and CH2O column densities can be an effective predictor for daily maximum 8-h average ozone. Furthermore, this indirect retrieval approach is shown to be complementary to spatial interpolation of surface observations, especially in regions where the surface sites are sparse. Combining column observations of NO2 and CH2O with surface site measurements leads to an improved representation of surface ozone over simple kriging, increasing the R2 value from 0.53 to 0.64 at a surface site distance of 252 km. The improvements are even more significant with larger surface site distances. The simulation experiment suggests that the indirect satellite retrieval technique can potentially be a useful tool to derive the full spatial coverage of daily surface ozone fields if satellite observation uncertainty is moderate.

Improvements in GRACE Gravity Field Determination through Stochastic Observation Modeling

NASA Astrophysics Data System (ADS)

McCullough, C.; Bettadpur, S. V.

2016-12-01

Current unconstrained Release 05 GRACE gravity field solutions from the Center for Space Research (CSR RL05) assume random observation errors following an independent multivariate Gaussian distribution. This modeling of observations, a simplifying assumption, fails to account for long period, correlated errors arising from inadequacies in the background force models. Fully modeling the errors inherent in the observation equations, through the use of a full observation covariance (modeling colored noise), enables optimal combination of GPS and inter-satellite range-rate data and obviates the need for estimating kinematic empirical parameters during the solution process. Most importantly, fully modeling the observation errors drastically improves formal error estimates of the spherical harmonic coefficients, potentially enabling improved uncertainty quantification of scientific results derived from GRACE and optimizing combinations of GRACE with independent data sets and a priori constraints.

Continuing Improvement in the Planetary Ephemeris with VLBA Observations of Cassini

NASA Astrophysics Data System (ADS)

Jones, Dayton L.; Folkner, William M.; Jacobson, Robert A.; Jacobs, Christopher S.; Romney, Jonathan D.; Dhawan, Vivek; Fomalont, Edward B.

2016-06-01

During the past decade a continuing series of measurements of the barycentric position of the Saturn system in the inertial International Celestial Reference Frame (ICRF) has led to a significant improvement in our knowledge of Saturn's orbit. This in turn has improved the current accuracy and time range of the solar system ephemeris produced and maintained by the Jet Propulsion Laboratory. Our observing technique involves high-precision astrometry of the radio signal from Cassini with the NRAO Very Long Baseline Array, combined with solutions for the orbital motion of Cassini about the Saturn barycenter from Doppler tracking by the Deep Space Network. Our VLBA astrometry is done in a phase-referencing mode, providing nrad-level relative positions between Cassini and angularly nearby extragalactic radio sources. The positions of those reference radio sources are tied to the ICRF through dedicated VLBI observations by several groups around the world. We will present recent results from our astrometric observations of Cassini through early 2016. This program will continue until the end of the Cassini mission in 2017, although future improvement in Saturn's orbit will be more incremental because we have already covered more that a quarter of Saturn's orbital period. The Juno mission to Jupiter, which will orbit Jupiter for about 1.5 years starting in July 2016, will provide an excellent opportunity for us to apply the same VLBA astrometry technique to improve the orbit of Jupiter by a factor of several. The National Radio Astronomy Observatory is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc. This work made use of the Swinburne University of Technology software correlator, developed as part of the Australian Major National Research Facilities Program and operated under license. Part of this research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under contract

Bedtime Blood Pressure Chronotherapy Significantly Improves Hypertension Management.

PubMed

Hermida, Ramón C; Ayala, Diana E; Fernández, José R; Mojón, Artemio; Crespo, Juan J; Ríos, María T; Smolensky, Michael H

2017-10-01

Consistent evidence of numerous studies substantiates the asleep blood pressure (BP) mean derived from ambulatory BP monitoring (ABPM) is both an independent and a stronger predictor of cardiovascular disease (CVD) risk than are daytime clinic BP measurements or the ABPM-determined awake or 24-hour BP means. Hence, cost-effective adequate control of sleep-time BP is of marked clinical relevance. Ingestion time, according to circadian rhythms, of hypertension medications of 6 different classes and their combinations significantly improves BP control, particularly sleep-time BP, and reduces adverse effects. Copyright © 2017 Elsevier Inc. All rights reserved.

Improved Conceptual Models Methodology (ICoMM) for Validation of Non-Observable Systems

DTIC Science & Technology

2015-12-01

distribution is unlimited IMPROVED CONCEPTUAL MODELS METHODOLOGY (ICoMM) FOR VALIDATION OF NON-OBSERVABLE SYSTEMS by Sang M. Sok December 2015...REPORT TYPE AND DATES COVERED Dissertation 4. TITLE AND SUBTITLE IMPROVED CONCEPTUAL MODELS METHODOLOGY (ICoMM) FOR VALIDATION OF NON-OBSERVABLE...importance of the CoM. The improved conceptual model methodology (ICoMM) is developed in support of improving the structure of the CoM for both face and

A Mirror Therapy-Based Action Observation Protocol to Improve Motor Learning After Stroke.

PubMed

Harmsen, Wouter J; Bussmann, Johannes B J; Selles, Ruud W; Hurkmans, Henri L P; Ribbers, Gerard M

2015-07-01

Mirror therapy is a priming technique to improve motor function of the affected arm after stroke. To investigate whether a mirror therapy-based action observation (AO) protocol contributes to motor learning of the affected arm after stroke. A total of 37 participants in the chronic stage after stroke were randomly allocated to the AO or control observation (CO) group. Participants were instructed to perform an upper-arm reaching task as fast and as fluently as possible. All participants trained the upper-arm reaching task with their affected arm alternated with either AO or CO. Participants in the AO group observed mirrored video tapes of reaching movements performed by their unaffected arm, whereas participants in the CO group observed static photographs of landscapes. The experimental condition effect was investigated by evaluating the primary outcome measure: movement time (in seconds) of the reaching movement, measured by accelerometry. Movement time decreased significantly in both groups: 18.3% in the AO and 9.1% in the CO group. Decrease in movement time was significantly more in the AO compared with the CO group (mean difference = 0.14 s; 95% confidence interval = 0.02, 0.26; P = .026). The present study showed that a mirror therapy-based AO protocol contributes to motor learning after stroke. © The Author(s) 2014.

Using the Significant Learning Taxonomy and Active Learning to Improve Accounting Education

ERIC Educational Resources Information Center

Killian, Larita J.; Brandon, Christopher D.

2009-01-01

Like other members of the academy, accounting professors are challenged to improve student learning. We must help students move beyond the "bean counter" role and develop higher-level skills such as analysis, synthesis, and problem-solving. The Significant Learning Taxonomy was used as a template to improve learning in an introductory accounting…

Home Videophones Improve Direct Observation in Tuberculosis Treatment: A Mixed Methods Evaluation

PubMed Central

Wade, Victoria A.; Karnon, Jonathan; Eliott, Jaklin A.; Hiller, Janet E.

2012-01-01

Background The use of direct observation to monitor tuberculosis treatment is controversial: cost, practical difficulties, and lack of patient acceptability limit effectiveness. Telehealth is a promising alternative delivery method for improving implementation. This study aimed to evaluate the clinical and cost-effectiveness of a telehealth service delivering direct observation, compared to an in-person drive-around service. Methodology/Principal Findings The study was conducted within a community nursing service in South Australia. Telehealth patients received daily video calls at home on a desktop videophone provided by the nursing call center. A retrospective cohort study assessed the effectiveness of the telehealth and traditional forms of observation, defined by the proportion of missed observations recorded in case notes. This data was inputted to a model, estimating the incremental cost-effectiveness ratio (ICER) of telehealth. Semi-structured interviews were conducted with current patients, community nursing and Chest Clinic staff, concerning service acceptability, usability and sustainability. The percentage of missed observations for the telehealth service was 12.1 (n = 58), compared to 31.1 for the in-person service (n = 70). Most of the difference of 18.9% (95% CI: 12.2 – 25.4) was due to fewer pre-arranged absences. The economic analysis calculated the ICER to be AUD$1.32 (95% CI: $0.51 – $2.26) per extra day of successful observation. The video service used less staff time, and became dominant if implemented on a larger scale and/or with decreased technology costs. Qualitative analysis found enabling factors of flexible timing, high patient acceptance, staff efficiency, and Chest Clinic support. Substantial technical problems were manageable, and improved liaison between the nursing service and Chest Clinic was an unexpected side-benefit. Conclusions/Significance Home video observation is a patient-centered, resource efficient way of

Significant improvements in the practice patterns of adult related donor care in US transplant centers

PubMed Central

MBChB, Chloe Anthias; Shaw, Bronwen E; Kiefer, Deidre M; Liesveld, Jane L; Yared, Jean; Kambl, Rammurti T; D'Souza, Anita; Hematti, Peiman; Seftel, Matthew D; Norkin, Maxim; DeFilipp, Zachariah M; Kasow, Kimberly A; Abidi, Muneer H; Savani, Bipin N; Shah, Nirali N; Anderlini, Paolo; Diaz, Miguel A; Malone, Adriana K; Halter, Joerg P; Lazarus, Hillard M; Logan, Brent R; Switzer, Galen E; Pulsipher, Michael A; Confer, Dennis L; O'Donnell, Paul V

2016-01-01

Recent investigations have found a higher incidence of adverse events associated with hematopoietic cell donation in related donors (RDs) who have morbidities that if present in an unrelated donor (UD) would preclude donation. In the UD setting, regulatory standards ensure independent assessment of donors, one of several crucial measures to safeguard donor health and safety. A survey conducted by the Center for International Blood and Marrow Transplant Research (CIBMTR) Donor Health and Safety Working Committee in 2007 reported a potential conflict of interest in >70% US centers, where physicians had simultaneous responsibility for RDs and their recipients. Consequently, several international organizations have endeavored to improve practice through regulations and consensus recommendations. We hypothesized that the changes in the 2012 FACT-JACIE Standards, resulting from the CIBMTR study, will have significantly impacted practice. Accordingly, a follow-up survey of US transplant centers was conducted to assess practice changes since 2007, and investigate additional areas where RD care was predicted to differ from UD care. 73 centers (53%), performing 79% of US RD transplants responded. Significant improvements were observed since the earlier survey; 62% centers now ensure separation of RD and recipient care (P<0.0001). However, this study identifies several areas where RD management does not meet international donor care standards. Particular concerns include counseling and assessment of donors before HLA typing, with 61% centers first disclosing donor HLA results to an individual other than the donor, the use of unlicensed mobilization agents, and the absence of long-term donor follow-up. Recommendations for improvement are described. PMID:26597080

Targeted observations to improve tropical cyclone track forecasts in the Atlantic and eastern Pacific basins

NASA Astrophysics Data System (ADS)

Aberson, Sim David

In 1997, the National Hurricane Center and the Hurricane Research Division began conducting operational synoptic surveillance missions with the Gulfstream IV-SP jet aircraft to improve operational forecast models. During the first two years, twenty-four missions were conducted around tropical cyclones threatening the continental United States, Puerto Rico, and the Virgin Islands. Global Positioning System dropwindsondes were released from the aircraft at 150--200 km intervals along the flight track in the tropical cyclone environment to obtain wind, temperature, and humidity profiles from flight level (around 150 hPa) to the surface. The observations were processed and formatted aboard the aircraft and transmitted to the National Centers for Environmental Prediction (NCEP). There, they were ingested into the Global Data Assimilation System that subsequently provides initial and time-dependent boundary conditions for numerical models that forecast tropical cyclone track and intensity. Three dynamical models were employed in testing the targeting and sampling strategies. With the assimilation into the numerical guidance of all the observations gathered during the surveillance missions, only the 12-h Geophysical Fluid Dynamics Laboratory Hurricane Model forecast showed statistically significant improvement. Neither the forecasts from the Aviation run of the Global Spectral Model nor the shallow-water VICBAR model were improved with the assimilation of the dropwindsonde data. This mediocre result is found to be due mainly to the difficulty in operationally quantifying the storm-motion vector used to create accurate synthetic data to represent the tropical cyclone vortex in the models. A secondary limit on forecast improvements from the surveillance missions is the limited amount of data provided by the one surveillance aircraft in regular missions. The inability of some surveillance missions to surround the tropical cyclone with dropwindsonde observations is a possible

PNC27 anticancer peptide as targeting ligand significantly improved antitumor efficacy of Doxil in HDM2-expressing cells.

PubMed

Darban, Shahrzad Amiri; Badiee, Ali; Jaafari, Mahmoud Reza

2017-06-01

To investigate the potential of PNC27 peptide, 12-26 of p53 with high affinity for HDM2 protein, as targeting ligand for Doxil to improve its antitumor activity. Doxil postinserted with 25, 50, 100 and 200 PNC27 peptides per liposome. Flow cytometry and confocal analysis were performed on C26 colon carcinoma (HDM2 positive) and B16F0 melanoma (HDM2 negative) cells. In vivo studies were performed on BALB/c mice bearing C26 and C57BL/6 mice bearing B16F0 tumor models. PNC27-Doxil showed significant cellular uptake and cytotoxicity in C26 cells compared with Doxil. PNC27-Doxil (100 PNC27 peptide) significantly improved therapeutic efficacy of Doxil without compromising its biodistribution in C26 tumor. However, these results were not observed in B16F0 cells. PNC27 is a promising targeting ligand for Doxil against HDM2-positive cancers.

Improved Estimate of Phobos Secular Acceleration from MOLA Observations

NASA Technical Reports Server (NTRS)

Bills, Bruce; Neumann, Gregory; Smith, David; Zuber, Maria

2004-01-01

to the predicted values. Assuming that the along-track discrepancy is small enough that we can linearize the corrections, we model the mean orbital longitude as a quadratic function of time, and solve for corrections to the constant, linear, and quadratic terms. The time span of the recent observations is insufficient to properly resolve this issue alone, but when the 127 years of prior observations are added, we find a solution which reduces misfit to the new observations considerably, and makes no significant change to the fit to earlier observations. Our estimate for the secular acceleration term is (1.367 + 0.006) degrees per square year. The corresponding rate of energy dissipation is 3.34 MW. From a geophysical perspective, a more interesting parameter than the secular acceleration itself is the tidal lag angle, or tidal quality factor Q, for Mars. Unfortunately, the limiting error source in that determination is remaining uncertainty in the tidal Love numbers at harmonic degrees 2,3, and even 4. Until those parameters are better constrained, improvement in the orbital model of Phobos will not provide corresponding benefits for understanding the interior of Mars.

Randomized Controlled Trial of a Home-Based Action Observation Intervention to Improve Walking in Parkinson Disease.

PubMed

Jaywant, Abhishek; Ellis, Terry D; Roy, Serge; Lin, Cheng-Chieh; Neargarder, Sandy; Cronin-Golomb, Alice

2016-05-01

To examine the feasibility and efficacy of a home-based gait observation intervention for improving walking in Parkinson disease (PD). Participants were randomly assigned to an intervention or control condition. A baseline walking assessment, a training period at home, and a posttraining assessment were conducted. The laboratory and participants' home and community environments. Nondemented individuals with PD (N=23) experiencing walking difficulty. In the gait observation (intervention) condition, participants viewed videos of healthy and parkinsonian gait. In the landscape observation (control) condition, participants viewed videos of moving water. These tasks were completed daily for 8 days. Spatiotemporal walking variables were assessed using accelerometers in the laboratory (baseline and posttraining assessments) and continuously at home during the training period. Variables included daily activity, walking speed, stride length, stride frequency, leg swing time, and gait asymmetry. Questionnaires including the 39-item Parkinson Disease Questionnaire (PDQ-39) were administered to determine self-reported change in walking, as well as feasibility. At posttraining assessment, only the gait observation group reported significantly improved mobility (PDQ-39). No improvements were seen in accelerometer-derived walking data. Participants found the at-home training tasks and accelerometer feasible to use. Participants found procedures feasible and reported improved mobility, suggesting that observational training holds promise in the rehabilitation of walking in PD. Observational training alone, however, may not be sufficient to enhance walking in PD. A more challenging and adaptive task, and the use of explicit perceptual learning and practice of actions, may be required to effect change. Copyright © 2016 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Improving a Spectral Bin Microphysical Scheme Using TRMM Satellite Observations

NASA Technical Reports Server (NTRS)

Li, Xiaowen; Tao, Wei-Kuo; Matsui, Toshihisa; Liu, Chuntao; Masunaga, Hirohiko

2010-01-01

Comparisons between cloud model simulations and observations are crucial in validating model performance and improving physical processes represented in the mod Tel.hese modeled physical processes are idealized representations and almost always have large rooms for improvements. In this study, we use data from two different sensors onboard TRMM (Tropical Rainfall Measurement Mission) satellite to improve the microphysical scheme in the Goddard Cumulus Ensemble (GCE) model. TRMM observed mature-stage squall lines during late spring, early summer in central US over a 9-year period are compiled and compared with a case simulation by GCE model. A unique aspect of the GCE model is that it has a state-of-the-art spectral bin microphysical scheme, which uses 33 different bins to represent particle size distribution of each of the seven hydrometeor species. A forward radiative transfer model calculates TRMM Precipitation Radar (PR) reflectivity and TRMM Microwave Imager (TMI) 85 GHz brightness temperatures from simulated particle size distributions. Comparisons between model outputs and observations reveal that the model overestimates sizes of snow/aggregates in the stratiform region of the squall line. After adjusting temperature-dependent collection coefficients among ice-phase particles, PR comparisons become good while TMI comparisons worsen. Further investigations show that the partitioning between graupel (a high-density form of aggregate), and snow (a low-density form of aggregate) needs to be adjusted in order to have good comparisons in both PR reflectivity and TMI brightness temperature. This study shows that long-term satellite observations, especially those with multiple sensors, can be very useful in constraining model microphysics. It is also the first study in validating and improving a sophisticated spectral bin microphysical scheme according to long-term satellite observations.

Inhibition of class IIb histone deacetylase significantly improves cloning efficiency in mice.

PubMed

Ono, Tetsuo; Li, Chong; Mizutani, Eiji; Terashita, Yukari; Yamagata, Kazuo; Wakayama, Teruhiko

2010-12-01

Since the first mouse clone was produced by somatic cell nuclear transfer, the success rate of cloning in mice has been extremely low. Some histone deacetylase inhibitors, such as trichostatin A and scriptaid, have improved the full-term development of mouse clones significantly, but the mechanisms allowing for this are unclear. Here, we found that two other specific inhibitors, suberoylanilide hydroxamic acid and oxamflatin, could also reduce the rate of apoptosis in blastocysts, improve the full-term development of cloned mice, and increase establishment of nuclear transfer-generated embryonic stem cell lines significantly without leading to obvious abnormalities. However, another inhibitor, valproic acid, could not improve cloning efficiency. Suberoylanilide hydroxamic acid, oxamflatin, trichostatin A, and scriptaid are inhibitors for classes I and IIa/b histone deacetylase, whereas valproic acid is an inhibitor for classes I and IIa, suggesting that inhibiting class IIb histone deacetylase is an important step for reprogramming mouse cloning efficiency.

Histological Observation of the Retinacula of Weitbrecht and Its Clinical Significance: A cadaveric study.

PubMed

Dou, Bang; Mei, Jiong; Wang, Zhiyuan; Ni, Ming; Jia, Guangyao; Liu, Shiwei

2018-01-01

The retinacular arteries provide major supply to the femoral head, their injuries may lead to the femoral head necrosis (FHN) in femoral neck fractures. Although the femoral neck fracture was seriously displaced in some patients, FHN did not occur, which suggests that the blood supply is not fully blocked. This study was aimed to find the association between the structure of the retinacula of Weitbrecht and the mechanism of protecting retinacular arteries from being injured. Fourteen formalin-fixed cadaveric specimens (in 28 hips) with no significant vascular disease were observed. The retinacula were cut longitudinally and then cut into three parts: medial, middle, and lateral. These specimens were stained using hematoxylin and eosin and improved Masson Trichrome stain. The microstructure and tightness of the retinacula fixed to the bone and the distribution of vessels were examined under a stereoscope, an optical microscope, and a scanning electron microscope. The microstructure and compactness in each part of retinacula were different, and the tightness of the fibers of the retinacula fixed to the bone in each part were different. A particular structure which resembled a Sandwich panels was observed, and it may be an effective mechanism of protecting retinacular arteries. The Sandwich panels structure existed generally in the retinacula of Weitbrecht, and this sandwich panelture may play very important role in protecting the retinaculum artery from being injured, which show the importance of protecting the retinacular artery in the treatment of femoral neck fractures.

Methylphenidate significantly improves declarative memory functioning of adults with ADHD.

PubMed

Verster, Joris C; Bekker, Evelijne M; Kooij, J J Sandra; Buitelaar, Jan K; Verbaten, Marinus N; Volkerts, Edmund R; Olivier, Berend

2010-10-01

Declarative memory deficits are common in untreated adults with attention-deficit hyperactivity disorder (ADHD), but limited evidence exists to support improvement after treatment with methylphenidate. The objective of this study was to examine the effects of methylphenidate on memory functioning of adults with ADHD. Eighteen adults with ADHD who were clinical responders to methylphenidate participated in this randomized crossover trial. After 3 days of no treatment, patients received in random order either their usual methylphenidate dose (mean: 14.7 mg; range: 10-30 mg) or placebo, separated by a 6-7-day washout period. Patients performed an immediate word recall test 1 h after treatment administration. Three hours after intake, patients performed the second part of the memory test (delayed word recall and a recognition test). Delayed recognition and immediate recall was similar on treatment and on placebo. Delayed word recall was significantly better in the methylphenidate than in the placebo condition (F (1, 17) = 7.0, p <  0.017). A significant correlation was found between prestudy CES-D depression scores and difference scores on delayed recall (r = 0.602, p <  0.008). Methylphenidate improves declarative memory functioning in patients with ADHD. New studies should further examine whether subclinical depressive symptoms mediate the effect of methylphenidate on declarative memory.

Using EFSO/PQC to Improve the Quality of Observations and Analyses

NASA Astrophysics Data System (ADS)

Chen, T. C.; Kalnay, E.

2017-12-01

Massive amounts of observations are assimilated every day into modern Numerical Weather Prediction (NWP) systems. This makes difficult to estimate the impact of a new observing system using the current approach (Observing System Experiments, OSEs) because there is already so much information provided by existing observations. In addition, the large volume of data also prevents monitoring the impact of each assimilated observation with OSEs. We demonstrate here how using Ensemble Forecast Sensitivity to Observations (EFSO) allows monitoring and improving the impact of observations on the analyses and forecasts in the Hybrid GSI/LETKF system. In addition, we show how EFSO can identify flow dependent detrimental observations from observing systems that, on the average, are beneficial. For example, using EFSO we find that positive zonal wind innovations in MODIS polar winds are generally detrimental, whereas no such bias is present in other satellite wind systems. We also show how EFSO can be used to identify and reject very detrimental observations (Proactive Quality Control, PQC). The withdrawal of these detrimental observations leads to improved analyses and 5-day forecasts, which also serves as a verification of EFSO. The operational implementation of PQC/EFSO is computationally very feasible, and will provide detailed QC monitoring of every observing system. Finally, we provide a theoretical justification of the PQC and its connection to dynamical instabilities with a simple Lorenz 96 model.

An Improved Perturb and Observe Algorithm for Photovoltaic Motion Carriers

NASA Astrophysics Data System (ADS)

Peng, Lele; Xu, Wei; Li, Liming; Zheng, Shubin

2018-03-01

An improved perturbation and observation algorithm for photovoltaic motion carriers is proposed in this paper. The model of the proposed algorithm is given by using Lambert W function and tangent error method. Moreover, by using matlab and experiment of photovoltaic system, the tracking performance of the proposed algorithm is tested. And the results demonstrate that the improved algorithm has fast tracking speed and high efficiency. Furthermore, the energy conversion efficiency by the improved method has increased by nearly 8.2%.

Significant Improvements in the Practice Patterns of Adult Related Donor Care in US Transplantation Centers.

PubMed

Anthias, Chloe; Shaw, Bronwen E; Kiefer, Deidre M; Liesveld, Jane L; Yared, Jean; Kamble, Rammurti T; D'Souza, Anita; Hematti, Peiman; Seftel, Matthew D; Norkin, Maxim; DeFilipp, Zachariah; Kasow, Kimberly A; Abidi, Muneer H; Savani, Bipin N; Shah, Nirali N; Anderlini, Paolo; Diaz, Miguel A; Malone, Adriana K; Halter, Joerg P; Lazarus, Hillard M; Logan, Brent R; Switzer, Galen E; Pulsipher, Michael A; Confer, Dennis L; O'Donnell, Paul V

2016-03-01

Recent investigations have found a higher incidence of adverse events associated with hematopoietic cell donation in related donors (RDs) who have morbidities that if present in an unrelated donor (UD) would preclude donation. In the UD setting, regulatory standards ensure independent assessment of donors, one of several crucial measures to safeguard donor health and safety. A survey conducted by the Center for International Blood and Marrow Transplant Research (CIBMTR) Donor Health and Safety Working Committee in 2007 reported a potential conflict of interest in >70% of US centers, where physicians had simultaneous responsibility for RDs and their recipients. Consequently, several international organizations have endeavored to improve practice through regulations and consensus recommendations. We hypothesized that the changes in the 2012 Foundation for the Accreditation of Cellular Therapy and the Joint Accreditation Committee-International Society for Cellular Therapy and European Society for Blood and Marrow Transplantation standards resulting from the CIBMTR study would have significantly impacted practice. Accordingly, we conducted a follow-up survey of US transplantation centers to assess practice changes since 2007, and to investigate additional areas where RD care was predicted to differ from UD care. A total of 73 centers (53%), performing 79% of RD transplantations in the United States, responded. Significant improvements were observed since the earlier survey; 62% centers now ensure separation of RD and recipient care (P < .0001). This study identifies several areas where RD management does not meet international donor care standards, however. Particular concerns include counseling and assessment of donors before HLA typing, with 61% centers first disclosing donor HLA results to an individual other than the donor, the use of unlicensed mobilization agents, and the absence of long-term donor follow-up. Recommendations for improvement are

Improving patient safety during insertion of peripheral venous catheters: an observational intervention study.

PubMed

Kampf, Günter; Reise, Gesche; James, Claudia; Gittelbauer, Kirsten; Gosch, Jutta; Alpers, Birgit

2013-01-01

Peripheral venous catheters are frequently used in hospitalized patients but increase the risk of nosocomial bloodstream infection. Evidence-based guidelines describe specific steps that are known to reduce infection risk. However, the degree of guideline implementation in clinical practice is not known. The aim of this study was to determine the use of specific steps for insertion of peripheral venous catheters in clinical practice and to implement a multimodal intervention aimed at improving both compliance and the optimum order of the steps. The study was conducted at University Hospital Hamburg. An optimum procedure for inserting a peripheral venous catheter was defined based on three evidence-based guidelines (WHO, CDC, RKI) including five steps with 1A or 1B level of evidence: hand disinfection before patient contact, skin antisepsis of the puncture site, no palpation of treated puncture site, hand disinfection before aseptic procedure, and sterile dressing on the puncture site. A research nurse observed and recorded procedures for peripheral venous catheter insertion for healthcare workers in four different departments (endoscopy, central emergency admissions, pediatrics, and dermatology). A multimodal intervention with 5 elements was established (teaching session, dummy training, e-learning tool, tablet and poster, and direct feedback), followed by a second observation period. During the last observation week, participants evaluated the intervention. In the control period, 207 insertions were observed, and 202 in the intervention period. Compliance improved significantly for four of five steps (e.g., from 11.6% to 57.9% for hand disinfection before patient contact; p<0.001, chi-square test). Compliance with skin antisepsis of the puncture site was high before and after intervention (99.5% before and 99.0% after). Performance of specific steps in the correct order also improved (e.g., from 7.7% to 68.6% when three of five steps were done; p<0.001). The

Improving patient safety during insertion of peripheral venous catheters: an observational intervention study

PubMed Central

Kampf, Günter; Reise, Gesche; James, Claudia; Gittelbauer, Kirsten; Gosch, Jutta; Alpers, Birgit

2013-01-01

Background: Peripheral venous catheters are frequently used in hospitalized patients but increase the risk of nosocomial bloodstream infection. Evidence-based guidelines describe specific steps that are known to reduce infection risk. However, the degree of guideline implementation in clinical practice is not known. The aim of this study was to determine the use of specific steps for insertion of peripheral venous catheters in clinical practice and to implement a multimodal intervention aimed at improving both compliance and the optimum order of the steps. Methods: The study was conducted at University Hospital Hamburg. An optimum procedure for inserting a peripheral venous catheter was defined based on three evidence-based guidelines (WHO, CDC, RKI) including five steps with 1A or 1B level of evidence: hand disinfection before patient contact, skin antisepsis of the puncture site, no palpation of treated puncture site, hand disinfection before aseptic procedure, and sterile dressing on the puncture site. A research nurse observed and recorded procedures for peripheral venous catheter insertion for healthcare workers in four different departments (endoscopy, central emergency admissions, pediatrics, and dermatology). A multimodal intervention with 5 elements was established (teaching session, dummy training, e-learning tool, tablet and poster, and direct feedback), followed by a second observation period. During the last observation week, participants evaluated the intervention. Results: In the control period, 207 insertions were observed, and 202 in the intervention period. Compliance improved significantly for four of five steps (e.g., from 11.6% to 57.9% for hand disinfection before patient contact; p<0.001, chi-square test). Compliance with skin antisepsis of the puncture site was high before and after intervention (99.5% before and 99.0% after). Performance of specific steps in the correct order also improved (e.g., from 7.7% to 68.6% when three of five steps

Quality of life improvement in HIV-1 patients treated with raltegravir in a real-life observational study: RACING.

PubMed

Spire, Bruno; Nait-Ighil, Lella; Pugliese, Pascal; Poizot-Martin, Isabelle; Jullien, Vincent; Marcelin, Anne-Geneviève; Billaud, Eric

2017-01-01

Good efficacy and safety of raltegravir in person living with HIV was demonstrated in clinical trials over five years, but real-life data, particularly about quality of life (QoL), are lacking. QoL was evaluated over time in adult patients first treated or switched to regimens containing raltegravir in an observational cohort study. Patient QoL was evaluated using the Fatigue Impact Scale (FIS) and the HIV Symptom Index (HSI). Data were collected at baseline and at 1, 3, 6, 12, 18, and 24 months. Baseline FIS and HSI subscores were compared with the scores at each visit using the paired Wilcoxon test. The impact of time, sociodemographic and medical variables upon patient-perceived fatigue and symptoms was also assessed using mixed multivariate models. From baseline, all FIS and HSI subscores improved significantly after one month of treatment. In addition, psychosocial FIS subscores and both the frequency of bothersome symptoms and HSI subscores improved significantly at each visit. Physical FIS subscores also improved significantly, except at month 18, whereas both cognitive and total FIS subscores improved only after 6 months and 24 months, respectively. In multivariate analysis, employment was independently associated over time with improved improvement in both FIS and HSI subscores. Patient QoL improved significantly over a 24-month period of treatment with a raltegravir-containing regimen. FIS and HSI are sensitive tools to measure the impact of new antiretroviral combinations on a patient's perception of QoL.

The significance of microwave observations for the planets

NASA Astrophysics Data System (ADS)

de Pater, Imke

1991-01-01

A review of radio observations of the giant and terrestrial planets is presented, together with a discussion as to how our understanding of the planets' surfaces, atmospheres and magnetospheres has improved with help of these data. Giant planet atmospheres. The radio spectra and resolved images of the four giant planets are compared. Jupiter and Saturn are very much alike: NH3 gas is depleted compared to what would be expected for a solar nitrogen abundance by a factor of ~5 at P <= 1-2 bar, and enhanced by ~1.5 at P > 2 bar on Jupiter and by 3-4 at P > 4-5 bar on Saturn. Bright bands across the planetary disks imply a latitudinal variation in the precise ammonia abundance. Uranus and Neptune are very different from the former two planets, in that they exhibit a depletion of NH3 gas by about two orders of magnitude over a large altitude range in the atmosphere. Uranus shows a large pole-to-equator gradient in brightness temperature. The loss of NH3 gas in all four planetary atmospheres is most likely due to the formation of NH4SH. This requires the H,S abundance in Jupiter and Saturn to be enhanced by a factor of 6-7 and 10-15 respectively above the solar value, and in Uranus and Neptune by over two orders of magnitude. The NH3 and H2S abundances derived from radio data support the "core-instability" models on planetary formation by Pollack and Bodenheimer [1989]. The latitudinal variation in the NH3 abundance on the planets suggests differences in the location of the NH4SH cloud layers and hence the dynamics of the planets. Jupiter's synchrotron radiation. Radio observations of Jupiter's synchrotron radiation have led to a detailed model of Jupiter's inner magnetosphere with electron distributions. The satellites Thebe and Amalthea cause the electrons to be confined to the magnetic equatorial plane. Energy degradation of the electrons by dust in Jupiter's ring harden the electron spectrum considerably. A "hot spot" in Jupiter's radiation belts can partly be

Data Assimilation using observed streamflow and remotely-sensed soil moisture for improving sub-seasonal-to-seasonal forecasting

NASA Astrophysics Data System (ADS)

Arumugam, S.; Mazrooei, A.; Lakshmi, V.; Wood, A.

2017-12-01

Subseasonal-to-seasonal (S2S) forecasts of soil moisture and streamflow provides critical information for water and agricultural systems to support short-term planning and mangement. This study evaluates the role of observed streamflow and remotely-sensed soil moisture from SMAP (Soil Moisture Active Passive) mission in improving S2S streamflow and soil moisture forecasting using data assimilation (DA). We first show the ability to forecast soil moisture at monthly-to-seaasonal time scale by forcing climate forecasts with NASA's Land Information System and then compares the developed soil moisture forecast with the SMAP data over the Southeast US. Our analyses show significant skill in forecasting real-time soil moisture over 1-3 months using climate information. We also show that the developed soil moisture forecasts capture the observed severe drought conditions (2007-2008) over the Southeast US. Following that, we consider both SMAP data and observed streamflow for improving S2S streamflow and soil moisture forecasts for a pilot study area, Tar River basin, in NC. Towards this, we consider variational assimilation (VAR) of gauge-measured daily streamflow data in improving initial hydrologic conditions of Variable Infiltration Capacity (VIC) model. The utility of data assimilation is then assessed in improving S2S forecasts of streamflow and soil moisture through a retrospective analyses. Furthermore, the optimal frequency of data assimilation and optimal analysis window (number of past observations to use) are also assessed in order to achieve the maximum improvement in S2S forecasts of streamflow and soil moisture. Potential utility of updating initial conditions using DA and providing skillful forcings are also discussed.

Improving the Transition of Earth Satellite Observations from Research to Operations

NASA Technical Reports Server (NTRS)

Goodman, Steven J.; Lapenta, William M.; Jedlovec, Gary J.

2004-01-01

There are significant gaps between the observations, models, and decision support tools that make use of new data. These challenges include: 1) Decreasing the time to incorporate new satellite data into operational forecast assimilation systems, 2) Blending in-situ and satellite observing systems to produce the most accurate and comprehensive data products and assessments, 3) Accelerating the transition from research to applications through national test beds, field campaigns, and pilot demonstrations, and 4) Developing the partnerships and organizational structures to effectively transition new technology into operations. At the Short-term Prediction Research and Transition (SPORT) Center in Huntsville, Alabama, a NASA-NOAA-University collaboration has been developed to accelerate the infusion of NASA Earth science observations, data assimilation and modeling research into NWS forecast operations and decision-making. The SPoRT Center research focus is to improve forecasts through new observation capability and the regional prediction objectives of the US Weather Research Program dealing with 0-1 day forecast issues such as convective initiation and 24-hr quantitative precipitation forecasting. The near real-time availability of high-resolution experimental products of the atmosphere, land, and ocean from the Moderate Resolution Imaging Spectroradiometer (MODIS), the Advanced Infrared Spectroradiometer (AIRS), and lightning mapping systems provide an opportunity for science and algorithm risk reduction, and for application assessment prior to planned observations from the next generation of operational low Earth orbiting and geostationary Earth orbiting satellites. This paper describes the process for the transition of experimental products into forecast operations, current products undergoing assessment by forecasters, and plans for the future. The SPoRT Web page is at (http://www.ghcc.msfc.nasa.gov/sport).

Home parenteral nutrition improves quality of life and nutritional status in patients with cancer: a French observational multicentre study.

PubMed

Culine, S; Chambrier, C; Tadmouri, A; Senesse, P; Seys, P; Radji, A; Rotarski, M; Balian, A; Dufour, P

2014-07-01

Malnutrition is a predictor of poor outcomes in patients with cancer. Little is known about the benefit of nutritional support in these patients. The purpose of this study was to assess the impact of home parenteral nutrition (HPN) on quality of life (Qol) in cancer patients. We performed an observational prospective study to determine the impact of HPN on Qol in a population of patients with heterogeneous cancer. Physicians, patients and family members had to complete a questionnaire before HPN administration and 28 days after the course of HPN. Qol was evaluated using the self-administered questionnaire FACT-G. We included 767 patients with cancer of whom 437 ended the study. Mean patient age was 63±11.4 years and 60.5% were men. Primary gastrointestinal cancer was reported in 50% of patients and 65.3% were presenting metastases. Malnutrition was reported in 98.3%. After 28 days of HPN intake, significant improvement was observed in the Qol (49.95±5.82 vs. 48.35±5.01 at baseline, p<0.0001). The mean weight, serum albumin and the nutrition risk index had also improved significantly. Most patients (78%) had perceived a positive impact of the HPN. A significant improvement in patient's well-being was perceived also by family members and physicians. Our data suggest that preventing and correcting malnutrition using HPN in patients with cancer might have a significant benefit on their well-being. Randomized controlled studies are required to confirm this finding.

Significantly improved neurocognitive function in major depressive disorders 6 weeks after ECT.

PubMed

Mohn, Christine; Rund, Bjørn Rishovd

2016-09-15

Cognitive side effects may occur after electroconvulsive treatment (ECT) in depressive disorder patients. Previous studies have been limited by small numbers of cognitive functions assessed. The present study reports the first results from a prospective project monitoring cognitive effects of ECT using a comprehensive neuropsychological test battery and subjective report of everyday cognitive function. Thirty-one patients with major depressive disorder were assessed with the MATRICS Consensus Cognitive Battery (MCCB). Subjective cognitive complaints were described with the Everyday Memory Questionnaire (EMQ). Severity of depression symptoms were assessed with the Montgomery-Åsberg Depression Rating Scale (MADRS). These assessments were performed prior to and 6 weeks after non-standardized ECT. Compared to baseline, the mean depression severity level was nearly halved and there were significant improvements in mean levels of Speed of Processing, Attention/Vigilance, and Visual Learning 6 weeks after ECT. The other cognitive domains were not altered from baseline. There was no significant change in subjective cognitive complaints. At baseline, there were several significant correlations between the MADRS and MCCB scores. There was no strong association between the EMQ and MCCB scores at either assessment point, but the post-ECT EMQ score was significantly correlated with depression severity. Major limitations were low N and lack of uniform ECT procedure. There was significant improvement in Speed of Processing, Attention/Vigilance, and Visual Learning 6 weeks after ECT. Cognitive tests scores were related to severity of depression, but not to subjective memory complaints. Copyright © 2016 Elsevier B.V. All rights reserved.

Improving Reanalyses Using TRMM and SSM/I-Derived Precipitation and Total Precipitable Water Observations

NASA Technical Reports Server (NTRS)

Hou, Arthur Y.; Zhang, Sara Q.; daSilva, Arlindo M.

1999-01-01

Global reanalyses currently contain significant errors in the primary fields of the hydrological cycle such as precipitation, evaporation, moisture, and the related cloud fields, especially in the tropics. The Data Assimilation Office (DAO) at the NASA Goddard Space Flight Center has been exploring the use of rainfall and total precipitable water (TPW) observations from the Tropical Rainfall Measuring Mission (TRMM) Microwave Imager (TMI) and the Special Sensor Microwave/ Imager (SSM/I) instruments to improve these fields in reanalyses. The DAO has developed a "1+1"D procedure to assimilate 6-hr averaged rainfall and TPW into the Goddard Earth Observing System (GEOS) Data Assimilation System (DAS). The algorithm is based on a 6-hr time integration of a column version of the GEOS DAS. The "1+1" designation refers to one spatial dimension plus one temporal dimension. The scheme minimizes the least-square differences between the satellite-retrieved rain rates and those produced by the column model over the 6-hr analysis window. The control variables are analysis increments of moisture within the Incremental Analysis Update (IAU) framework of the GEOS DAS. This 1+1D scheme, in its generalization to four dimensions, is related to the standard 4D variational assimilation but differs in its choice of the control variable. Instead of estimating the initial condition at the beginning of the assimilation cycle, it estimates the constant IAU forcing applied over a 6-hr assimilation cycle. In doing so, it imposes the forecast model as a weak constraint in a manner similar to the variational continuous assimilation techniques. We present results from an experiment in which the observed rain rate and TPW are assumed to be "perfect". They show that assimilating the TMI and SSM/I-derived surface precipitation and TPW observations improves not only the precipitation and moisture fields but also key climate parameters directly linked to convective activities such as clouds, the

Improving Global Reanalyses and Short Range Forecast Using TRMM and SSM/I-Derived Precipitation and Moisture Observations

NASA Technical Reports Server (NTRS)

Hou, Arthur Y.; Zhang, Sara Q.; deSilva, Arlindo M.

2000-01-01

Global reanalyses currently contain significant errors in the primary fields of the hydrological cycle such as precipitation, evaporation, moisture, and the related cloud fields, especially in the tropics. The Data Assimilation Office (DAO) at the NASA Goddard Space Flight Center has been exploring the use of tropical rainfall and total precipitable water (TPW) observations from the TRMM Microwave Imager (TMI) and the Special Sensor Microwave/ Imager (SSM/I) instruments to improve short-range forecast and reanalyses. We describe a "1+1"D procedure for assimilating 6-hr averaged rainfall and TPW in the Goddard Earth Observing System (GEOS) Data Assimilation System (DAS). The algorithm is based on a 6-hr time integration of a column version of the GEOS DAS, hence the "1+1"D designation. The scheme minimizes the least-square differences between the observed TPW and rain rates and those produced by the column model over the 6-hr analysis window. This 1+lD scheme, in its generalization to four dimensions, is related to the standard 4D variational assimilation but uses analysis increments instead of the initial condition as the control variable. Results show that assimilating the TMI and SSM/I rainfall and TPW observations improves not only the precipitation and moisture fields but also key climate parameters such as clouds, the radiation, the upper-tropospheric moisture, and the large-scale circulation in the tropics. In particular, assimilating these data reduce the state-dependent systematic errors in the assimilated products. The improved analysis also provides better initial conditions for short-range forecasts, but the improvements in forecast are less than improvements in the time-averaged assimilation fields, indicating that using these data types is effective in correcting biases and other errors of the forecast model in data assimilation.

Improving Global Reanalyses and Short-Range Forecast Using TRMM and SSM/I-Derived Precipitation and Moisture Observations

NASA Technical Reports Server (NTRS)

Hou, Arthur Y.; Zhang, Sara Q.; daSilva, Arlindo M.

1999-01-01

Global reanalyses currently contain significant errors in the primary fields of the hydrological cycle such as precipitation, evaporation, moisture, and the related cloud fields, especially in the tropics. The Data Assimilation Office (DAO) at the NASA Goddard Space Flight Center has been exploring the use of tropical rainfall and total precipitable water (TPW) observations from the TRMM Microwave Imager (TMI) and the Special Sensor Microwave/ Imager (SSM/I) instruments to improve short-range forecast and reanalyses. We describe a 1+1D procedure for assimilating 6-hr averaged rainfall and TPW in the Goddard Earth Observing System (GEOS) Data Assimilation System (DAS). The algorithm is based on a 6-hr time integration of a column version of the GEOS DAS, hence the 1+1D designation. The scheme minimizes the least-square differences between the observed TPW and rain rates and those produced by the column model over the 6-hr analysis window. This 1+1D scheme, in its generalization to four dimensions, is related to the standard 4D variational assimilation but uses analysis increments instead of the initial condition as the control variable. Results show that assimilating the TMI and SSW rainfall and TPW observations improves not only the precipitation and moisture fields but also key climate parameters such as clouds, the radiation, the upper-tropospheric moisture, and the large-scale circulation in the tropics. In particular, assimilating these data reduce the state-dependent systematic errors in the assimilated products. The improved analysis also provides better initial conditions for short-range forecasts, but the improvements in forecast are less than improvements in the time-averaged assimilation fields, indicating that using these data types is effective in correcting biases and other errors of the forecast model in data assimilation.

Delayed Post-ischemic Conditioning Significantly Improves the Outcome after Retinal Ischemia

PubMed Central

Dreixler, John C.; Poston, Jacqueline N.; Shaikh, Afzhal R.; Alexander, Michael; Tupper, Kelsey Y.; Marcet, Marcus M.; Bernaudin, Myriam; Roth, Steven

2011-01-01

In previous studies, it was shown that post-conditioning, a transient period of brief ischemia following prolonged severe ischemia in the retina, could provide significant improvement in post-ischemic recovery, attenuation of cell loss, and decreased apoptosis. These studies showed that post-conditioning effectively prevented damage after retinal ischemia when it was instituted early (within one hour) in the post-ischemic period. While post-ischemic conditioning holds high promise of clinical translation, patients often present late after the onset of retinal ischemia and therefore immediate application of this anti-ischemic maneuver is generally not feasible. In this study, we examined the hypothesis that application of a post-conditioning stimulus at 24 h or greater following the end of prolonged ischemia would decrease the extent of ischemic injury. Ischemia was induced in rat retina in vivo. Recovery after ischemia followed by 5 minutes of post-conditioning brief ischemia 24 or 48 h after prolonged ischemia was assessed functionally (electroretinography) and histologically at 7 days after ischemia and post-conditioning or sham post-conditioning. We found that the brief ischemic stimulus applied 24, but not 48 h after prolonged ischemia significantly improved functional recovery and decreased histological damage induced by prolonged ischemia. We conclude that within a defined time window, delayed post-ischemic conditioning ameliorated post-ischemic injury in rats. Compared to earlier studies, the present work demonstrates for the first time the novel ability of a significantly delayed ischemic stimulus to provide robust neuroprotection in the retina following ischemia. PMID:21501608

Unified Health Gamification can significantly improve well-being in corporate environments.

PubMed

Shahrestani, Arash; Van Gorp, Pieter; Le Blanc, Pascale; Greidanus, Fabrizio; de Groot, Kristel; Leermakers, Jelle

2017-07-01

There is a multitude of mHealth applications that aim to solve societal health problems by stimulating specific types of physical activities via gamification. However, physical health activities cover just one of the three World Health Organization (WHO) dimensions of health. This paper introduces the novel notion of Unified Health Gamification (UHG), which covers besides physical health also social and cognitive health and well-being. Instead of rewarding activities in the three WHO dimensions using different mHealth competitions, UHG combines the scores for such activities on unified leaderboards and lets people interact in social circles beyond personal interests. This approach is promising in corporate environments since UHG can connect the employees with intrinsic motivation for physical health with those who have quite different interests. In order to evaluate this approach, we realized an app prototype and we evaluated it in two corporate pilot studies. In total, eighteen pilot users participated voluntarily for six weeks. Half of the participants were recruited from an occupational health setting and the other half from a treatment setting. Our results suggest that the UHG principles are worth more investigation: various positive health effects were found based on a validated survey. The mean mental health improved significantly at one pilot location and at the level of individual pilot participants, multiple other effects were found to be significant: among others, significant mental health improvements were found for 28% of the participants. Most participants intended to use the app beyond the pilot, especially if it would be further developed.

Significant inconsistency of vegetation carbon density in CMIP5 Earth system models against observational data: Vegetation Carbon Density in ESMs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Song, Xia; Hoffman, Forrest M.; Iversen, Colleen M.

Earth system models (ESMs) have been widely used for projecting global vegetation carbon dynamics, yet how well ESMs performed for simulating vegetation carbon density remains untested. Here we have compiled observational data of vegetation carbon density from literature and existing data sets to evaluate nine ESMs at site, biome, latitude, and global scales. Three variables—root (including fine and coarse roots), total vegetation carbon density, and the root:total vegetation carbon ratios (R/T ratios), were chosen for ESM evaluation. ESM models performed well in simulating the spatial distribution of carbon densities in root (r = 0.71) and total vegetation (r = 0.62).more » However, ESM models had significant biases in simulating absolute carbon densities in root and total vegetation biomass across the majority of land ecosystems, especially in tropical and arctic ecosystems. Particularly, ESMs significantly overestimated carbon density in root (183%) and total vegetation biomass (167%) in climate zones of 10°S–10°N. Substantial discrepancies between modeled and observed R/T ratios were found: the R/T ratios from ESMs were relatively constant, approximately 0.2 across all ecosystems, along latitudinal gradients, and in tropic, temperate, and arctic climatic zones, which was significantly different from the observed large variations in the R/T ratios (0.1–0.8). There were substantial inconsistencies between ESM-derived carbon density in root and total vegetation biomass and the R/T ratio at multiple scales, indicating urgent needs for model improvements on carbon allocation algorithms and more intensive field campaigns targeting carbon density in all key vegetation components.« less

Significant inconsistency of vegetation carbon density in CMIP5 Earth system models against observational data: Vegetation Carbon Density in ESMs

DOE PAGES

Song, Xia; Hoffman, Forrest M.; Iversen, Colleen M.; ...

2017-09-09

Earth system models (ESMs) have been widely used for projecting global vegetation carbon dynamics, yet how well ESMs performed for simulating vegetation carbon density remains untested. Here we have compiled observational data of vegetation carbon density from literature and existing data sets to evaluate nine ESMs at site, biome, latitude, and global scales. Three variables—root (including fine and coarse roots), total vegetation carbon density, and the root:total vegetation carbon ratios (R/T ratios), were chosen for ESM evaluation. ESM models performed well in simulating the spatial distribution of carbon densities in root (r = 0.71) and total vegetation (r = 0.62).more » However, ESM models had significant biases in simulating absolute carbon densities in root and total vegetation biomass across the majority of land ecosystems, especially in tropical and arctic ecosystems. Particularly, ESMs significantly overestimated carbon density in root (183%) and total vegetation biomass (167%) in climate zones of 10°S–10°N. Substantial discrepancies between modeled and observed R/T ratios were found: the R/T ratios from ESMs were relatively constant, approximately 0.2 across all ecosystems, along latitudinal gradients, and in tropic, temperate, and arctic climatic zones, which was significantly different from the observed large variations in the R/T ratios (0.1–0.8). There were substantial inconsistencies between ESM-derived carbon density in root and total vegetation biomass and the R/T ratio at multiple scales, indicating urgent needs for model improvements on carbon allocation algorithms and more intensive field campaigns targeting carbon density in all key vegetation components.« less

Looking is not seeing: using art to improve observational skills.

PubMed

Pellico, Linda Honan; Friedlaender, Linda; Fennie, Kristopher P

2009-11-01

This project evaluated the effects of an art museum experience on the observational skills of nursing students. Half of a class of non-nurse college graduates entering an accelerated master's degree program (n = 34) were assigned to a museum experience, whereas the other half (n = 32) received traditional teaching methods. Using original works of art, students participated in focused observational experiences to visually itemize everything noted in the art piece, discriminate visual qualities, recognize patterns, and cluster observations. After organizing observed information, they drew conclusions to construct the object's meaning. Participants visiting the museum subsequently wrote more about what they saw, resulting in significantly more objective clinical findings when viewing patient photographs. In addition, participants demonstrated significantly more fluidity in their differential diagnosis by offering more alternative diagnoses than did the control group. The study supports the notion that focused viewing of works of art enhances observational skills. Copyright 2009, SLACK Incorporated.

Compression stockings significantly improve hemodynamic performance in post-thrombotic syndrome irrespective of class or length.

PubMed

Lattimer, Christopher R; Azzam, Mustapha; Kalodiki, Evi; Makris, Gregory C; Geroulakos, George

2013-07-01

Graduated elastic compression (GEC) stockings have been demonstrated to reduce the morbidity associated with post-thrombotic syndrome. The ideal length or compression strength required to achieve this is speculative and related to physician preference and patient compliance. The aim of this study was to evaluate the hemodynamic performance of four different stockings and determine the patient's preference. Thirty-four consecutive patients (40 legs, 34 male) with post-thrombotic syndrome were tested with four different stockings (Mediven plus open toe, Bayreuth, Germany) of their size in random order: class 1 (18-21 mm Hg) and class II (23-32 mm Hg), below-knee (BK) and above-knee thigh-length (AK). The median age, Venous Clinical Severity Score, Venous Segmental Disease Score, and Villalta scale were 62 years (range, 31-81 years), 8 (range, 1-21), 5 (range, 2-10), and 10 (range, 2-22), respectively. The C of C0-6EsAs,d,pPr,o was C0 = 2, C2 = 1, C3 = 3, C4a = 12, C4b = 7, C5 = 12, C6 = 3. Obstruction and reflux was observed on duplex in 47.5% legs, with deep venous reflux alone in 45%. Air plethysmography was used to measure the venous filling index (VFI), venous volume, and time to fill 90% of the venous volume. Direct pressure measurements were obtained while lying and standing using the PicoPress device (Microlab Elettronica, Nicolò, Italy). The pressure sensor was placed underneath the test stocking 5 cm above and 2 cm posterior to the medial malleolus. At the end of the study session, patients stated their preferred stocking based on comfort. The VFI, venous volume, and time to fill 90% of the venous volume improved significantly with all types of stocking versus no compression. In class I, the VFI (mL/s) improved from a median of 4.9 (range, 1.7-16.3) without compression to 3.7 (range, 0-14) BK (24.5%) and 3.6 (range, 0.6-14.5) AK (26.5%). With class II, the corresponding improvement was to 4.0 (range, 0.3-16.2) BK (18.8%) and 3.7 (range, 0.5-14.2) AK (24

Corticosteroid transdermal delivery significantly improves arthritis pain and functional disability.

PubMed

Iannitti, Tommaso; McDermott, Michael F; Laurino, Carmen; Malagoli, Andrea; Palmieri, Beniamino

2017-02-01

Arthritis is characterized by pain and functional limitation affecting the patients' quality of life. We performed a clinical study to investigate the efficacy of a betamethasone valerate medicated plaster (Betesil) in improving pain and functional disability in patients with arthritis and osteoarthritis. We enrolled 104 patients affected by osteoarthritis (n = 40) or arthritis (n = 64) in different joints. Patients received diclofenac sodium cream (2 g, four times a day) or a 2.25-mg dose of Betesil applied to the painful joint every night before bedtime for 10 days. Pain and functional disability were assessed, by the Visual Analogue Scale (VAS) and Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) scores. Redness was assessed by clinical inspection, and edema by the "fovea sign" method. C-reactive protein (CRP) was also measured; CRP can be used to cost-effectively monitor the pharmacological treatment efficacy and is increased during the acute-phase response, returning to physiological values after tissue recovery and functional restoration. All measurements were at baseline and at 10-day follow-up. At 10-day follow-up, a greater improvement in VAS and WOMAC pain and WOMAC stiffness and functional limitation scores from baseline was observed in patients treated with Betesil compared with diclofenac (all p < 0.01). At 10-day follow-up, improvement in redness, edema, and CRP levels from baseline was also greater in patients treated with Betesil compared with diclofenac (all p < 0.01). This study demonstrates the safety and efficacy of transdermal delivery of betamethasone valerate in patients affected by arthritis and osteoarthritis.

Determination of significance in Ecological Impact Assessment: Past change, current practice and future improvements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Briggs, Sam; Hudson, Malcolm D., E-mail: mdh@soton.ac.uk

2013-01-15

Ecological Impact Assessment (EcIA) is an important tool for conservation and achieving sustainable development. 'Significant' impacts are those which disturb or alter the environment to a measurable degree. Significance is a crucial part of EcIA, our understanding of the concept in practice is vital if it is to be effective as a tool. This study employed three methods to assess how the determination of significance has changed through time, what current practice is, and what would lead to future improvements. Three data streams were collected: interviews with expert stakeholders, a review of 30 Environmental Statements and a broad-scale survey ofmore » the United Kingdom Institute of Ecology and Environmental Management (IEEM) members. The approach taken in the determination of significance has become more standardised and subjectivity has become constrained through a transparent framework. This has largely been driven by a set of guidelines produced by IEEM in 2006. The significance of impacts is now more clearly justified and the accuracy with which it is determined has improved. However, there are limitations to accuracy and effectiveness of the determination of significance. These are the quality of baseline survey data, our scientific understanding of ecological processes and the lack of monitoring and feedback of results. These in turn are restricted by the limited resources available in consultancies. The most notable recommendations for future practice are the implementation of monitoring and the publication of feedback, the creation of a central database for baseline survey data and the streamlining of guidance. - Highlights: Black-Right-Pointing-Pointer The assessment of significance has changed markedly through time. Black-Right-Pointing-Pointer The IEEM guidelines have driven a standardisation of practice. Black-Right-Pointing-Pointer Currently limited by quality of baseline data and scientific understanding. Black-Right-Pointing-Pointer Monitoring

Improved modeling of photon observables with the event-by-event fission model FREYA

DOE PAGES

Vogt, R.; Randrup, J.

2017-12-28

The event-by-event fission model FREYA has been improved, in particular to address deficiencies in the calculation of photon observables. In this paper, we discuss the improvements that have been made and introduce several new variables, some detector dependent, that affect the photon observables. We show the sensitivity of FREYA to these variables. Finally, we then compare the results to the available photon data from spontaneous and thermal neutron-induced fission.

Improved human observer performance in digital reconstructed radiograph verification in head and neck cancer radiotherapy.

PubMed

Sturgeon, Jared D; Cox, John A; Mayo, Lauren L; Gunn, G Brandon; Zhang, Lifei; Balter, Peter A; Dong, Lei; Awan, Musaddiq; Kocak-Uzel, Esengul; Mohamed, Abdallah Sherif Radwan; Rosenthal, David I; Fuller, Clifton David

2015-10-01

Digitally reconstructed radiographs (DRRs) are routinely used as an a priori reference for setup correction in radiotherapy. The spatial resolution of DRRs may be improved to reduce setup error in fractionated radiotherapy treatment protocols. The influence of finer CT slice thickness reconstruction (STR) and resultant increased resolution DRRs on physician setup accuracy was prospectively evaluated. Four head and neck patient CT-simulation images were acquired and used to create DRR cohorts by varying STRs at 0.5, 1, 2, 2.5, and 3 mm. DRRs were displaced relative to a fixed isocenter using 0-5 mm random shifts in the three cardinal axes. Physician observers reviewed DRRs of varying STRs and displacements and then aligned reference and test DRRs replicating daily KV imaging workflow. A total of 1,064 images were reviewed by four blinded physicians. Observer errors were analyzed using nonparametric statistics (Friedman's test) to determine whether STR cohorts had detectably different displacement profiles. Post hoc bootstrap resampling was applied to evaluate potential generalizability. The observer-based trial revealed a statistically significant difference between cohort means for observer displacement vector error ([Formula: see text]) and for [Formula: see text]-axis [Formula: see text]. Bootstrap analysis suggests a 15% gain in isocenter translational setup error with reduction of STR from 3 mm to [Formula: see text]2 mm, though interobserver variance was a larger feature than STR-associated measurement variance. Higher resolution DRRs generated using finer CT scan STR resulted in improved observer performance at shift detection and could decrease operator-dependent geometric error. Ideally, CT STRs [Formula: see text]2 mm should be utilized for DRR generation in the head and neck.

Improved large-scale hydrological modelling through the assimilation of streamflow and downscaled satellite soil moisture observations.

NASA Astrophysics Data System (ADS)

López López, Patricia; Wanders, Niko; Sutanudjaja, Edwin; Renzullo, Luigi; Sterk, Geert; Schellekens, Jaap; Bierkens, Marc

2015-04-01

moisture and streamflow, is more pronounced when the global meteorological data are used to force the models. This is caused by the higher uncertainty and coarser resolution of the global forcing. This study demonstrates that it is possible to improve hydrological simulations forced by coarse resolution meteorological data with downscaled satellite soil moisture and streamflow observations and bring them closer to a hydrological model forced with local climatological data. These findings are important in light of the efforts that are currently done to go to global hyper-resolution modelling and can significantly help to advance this research.

Improved satellite observations in coastal areas from altimetry and SAR

NASA Astrophysics Data System (ADS)

Cipollini, Paolo; Martin, Adrien; Gommenginger, Christine; Calafat, Francisco

2017-04-01

The coastal environment is under constant pressure by natural forces and anthropogenic activities and is very sensitive to climate change. Observations of many physical and biological parameters are critical for its monitoring and management. Satellite observations constitute an efficient way to observe the global coastal environment, but ocean satellite observations have often been designed and optimised for the open ocean: algorithms and processing techniques need to be revisited and adapted for application in the coastal zone. A case in point is that of satellite altimetry, which over the oceans is regarded as one of the most successful remote sensing techniques, as it has allowed an unprecedented mapping of the ocean surface dynamics at the large- and meso-scale. With the improvements in orbit models, radar processing, atmospheric and geophysical effect corrections that have emerged over the years, altimetry gives today also a very accurate estimation of the rate of sea level rise and its geographical variability. However, altimetric data in the near-land strip (0 to 50 km from the coastline) are often flagged as bad and left unused, essentially owing to 1) difficulties with the corrections; and/or 2) the modification of the radar returns due to the presence of land in the footprint, which makes the fitting of the altimetric echoes with a waveform model (the so-called "retracking") problematic. Techniques to recover meaningful estimates of the altimeter-derived parameters (height, significant wave height and wind) in the coastal zone have been developed and lead to a number of new applications, which will be presented here. The new observation from coastal altimetry are highly synergistic with Synthetic Aperture Radar (SAR). SAR imagers measure the backscattered signal from the ocean surface at spatial resolution better than 100m. This backscattered signal gives knowledge on the sea surface roughness, which is related to wind and waves. The very high resolution

Pretreatment of bovine sperm with dithiobutylamine (DTBA) significantly improves embryo development after ICSI

PubMed Central

SUTTIROJPATTANA, Tayita; SOMFAI, Tamas; MATOBA, Satoko; NAGAI, Takashi; PARNPAI, Rangsun; GESHI, Masaya

2016-01-01

We assessed the effect of pretreating sperm with dithiobutylamine (DTBA) to improve embryo development by intracytoplasmic sperm injection (ICSI) in cows. Acridine Orange staining revealed that when applied at different concentrations (2.5, 5, and 10 mM) and exposure times (5 min, 20 min, 1 h, and 2 h), DTBA reduced disulfide bonds in spermatozoa with the highest efficacy at 5 mM for 5 min. DTBA enhanced the percentage of spermatozoa with free protamine thiol groups compared with untreated spermatozoa (control) (P < 0.05); however, this result did not differ from that of dithiothreitol (DTT) treatment. The percentage of live spermatozoa after DTBA treatment was identical to that in the control, but significantly higher than that after DTT treatment (P < 0.05). After ICSI, DTBA treatment tended to improve male pronuclear formation rate (P = 0.071) compared with non-treated sperm injection. Blastocyst formation rate was significantly improved by DTBA treatment compared with that in DTT, control, and sham injection groups (P < 0.05). Blastocyst quality in terms of cell numbers and ploidy was not different among these groups. In conclusion, DTBA increases the efficacy of blastocyst production by ICSI even if DTT treatment does not work. PMID:27523189

APD125, a Selective Serotonin 5-HT2A Receptor Inverse Agonist, Significantly Improves Sleep Maintenance in Primary Insomnia

PubMed Central

Rosenberg, Russell; Seiden, David J.; Hull, Steven G.; Erman, Milton; Schwartz, Howard; Anderson, Christen; Prosser, Warren; Shanahan, William; Sanchez, Matilde; Chuang, Emil; Roth, Thomas

2008-01-01

Introduction: Insomnia is a condition affecting 10% to 15% of the adult population and is characterized by difficulty falling asleep, difficulty staying asleep, or nonrestorative sleep, accompanied by daytime impairment or distress. This study evaluates APD125, a selective inverse agonist of the 5-HT2A receptor, for treatment of chronic insomnia, with particular emphasis on sleep maintenance. In phase 1 studies, APD125 improved sleep maintenance and was well tolerated. Methodology: Adult subjects (n = 173) with DSM-IV defined primary insomnia were randomized into a multicenter, double-blind, placebo-controlled, 3-way crossover study to compare 2 doses of APD125 (10 mg and 40 mg) with placebo. Each treatment period was 7 days with a 7- to 9-day washout period between treatments. Polysomnographic recordings were performed at the initial 2 screening nights and at nights (N) 1/2 and N 6/7 of each treatment period. Results: APD125 was associated with significant improvements in key sleep maintenance parameters measured by PSG. Wake time after sleep onset decreased (SEM) by 52.5 (3.2) min (10 mg) and 53.5 (3.5) min (40 mg) from baseline to N 1/2 vs. 37.8 (3.4) min for placebo, (P < 0.0001 for both doses vs placebo), and by 51.7 (3.4) min (P = 0.01) and 48.0 (3.6) min (P = 0.2) at N 6/7 vs. 44.0 (3.8) min for placebo. Significant APD125 effects on wake time during sleep were also seen (P < 0.0001 N 1/2, P < 0.001 N 6/7). The number of arousals and number of awakenings decreased significantly with APD125 treatment compared to placebo. Slow wave sleep showed a statistically significant dose-dependent increase. There was no significant decrease in latency to persistent sleep. No serious adverse events were reported, and no meaningful differences in adverse event profiles were observed between either dose of APD125 and placebo. APD125 was not associated with next-day psychomotor impairment as measured by Digit Span, Digit Symbol Copy, and Digit Symbol Coding Tests

Fusion of mobile in situ and satellite remote sensing observations of chemical release emissions to improve disaster response

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leifer, Ira; Melton, Christopher; Frash, Jason

Chemical release disasters have serious consequences, disrupting ecosystems, society, and causing significant loss of life. Mitigating the destructive impacts relies on identification and mapping, monitoring, and trajectory forecasting. Improvements in sensor capabilities are enabling airborne and space-based remote sensing to support response activities. Key applications are improving transport models in complex terrain and improved disaster response. Understanding urban atmospheric transport in the Los Angeles Basin, where topographic influences on transport patterns are significant, was improved by leveraging the Aliso Canyon leak as an atmospheric tracer. Plume characterization data was collected by the AutoMObile trace Gas (AMOG) Surveyor, a commuter carmore » modified for science. Mobile surface in situ CH 4 and winds were measured by AMOG Surveyor under Santa Ana conditions to estimate an emission rate of 365±30% Gg yr -1. Vertical profiles were collected by AMOG Surveyor by leveraging local topography for vertical profiling to identify the planetary boundary layer at ~700 m. Topography significantly constrained plume dispersion by up to a factor of two. The observed plume trajectory was used to validate satellite aerosol optical depth-inferred atmospheric transport, which suggested the plume first was driven offshore, but then veered back towards land. Numerical long-range transport model predictions confirm this interpretation. Lastly, this study demonstrated a novel application of satellite aerosol remote sensing for disaster response.« less

Fusion of mobile in situ and satellite remote sensing observations of chemical release emissions to improve disaster response

DOE PAGES

Leifer, Ira; Melton, Christopher; Frash, Jason; ...

2016-09-22

Chemical release disasters have serious consequences, disrupting ecosystems, society, and causing significant loss of life. Mitigating the destructive impacts relies on identification and mapping, monitoring, and trajectory forecasting. Improvements in sensor capabilities are enabling airborne and space-based remote sensing to support response activities. Key applications are improving transport models in complex terrain and improved disaster response. Understanding urban atmospheric transport in the Los Angeles Basin, where topographic influences on transport patterns are significant, was improved by leveraging the Aliso Canyon leak as an atmospheric tracer. Plume characterization data was collected by the AutoMObile trace Gas (AMOG) Surveyor, a commuter carmore » modified for science. Mobile surface in situ CH 4 and winds were measured by AMOG Surveyor under Santa Ana conditions to estimate an emission rate of 365±30% Gg yr -1. Vertical profiles were collected by AMOG Surveyor by leveraging local topography for vertical profiling to identify the planetary boundary layer at ~700 m. Topography significantly constrained plume dispersion by up to a factor of two. The observed plume trajectory was used to validate satellite aerosol optical depth-inferred atmospheric transport, which suggested the plume first was driven offshore, but then veered back towards land. Numerical long-range transport model predictions confirm this interpretation. Lastly, this study demonstrated a novel application of satellite aerosol remote sensing for disaster response.« less

Neuro-Linguistic Programming: Improving Rapport between Track/Cross Country Coaches and Significant Others

ERIC Educational Resources Information Center

Helm, David Jay

2017-01-01

This study examines the background information and the components of N.L.P., being eye movements, use of predicates, and posturing, as they apply to improving rapport and empathy between track/cross country coaches and their significant others in the arena of competition to help alleviate the inherent stressors.

Assimilation of Sentinel-1 and SMAP observations to improve GEOS-5 soil moisture

NASA Astrophysics Data System (ADS)

Lievens, Hans; Reichle, Rolf; Wagner, Wolfgang; De Lannoy, Gabrielle; Liu, Qing; Verhoest, Niko

2017-04-01

The SMAP (Soil Moisture Active and Passive) mission carries an L-band radiometer that provides brightness temperature observations at a nominal resolution of 40 km. These radiance observations are routinely assimilated into GEOS-5 (Goddard Earth Observing System version 5) to generate the SMAP Level 4 Soil Moisture product. The use of C-band radar backscatter observations from Sentinel-1 has the potential to add value to the radiance assimilation by increasing the level of spatial detail. The specifications of Sentinel-1 are appealing, particularly its high spatial resolution (5 by 20 m in interferometric wide swath mode) and frequent revisit time (potentially every 3 days for the Sentinel-1A and Sentinel-1B constellation). However, the shorter wavelength of Sentinel-1 observations implies less sensitivity to soil moisture. This study investigates the value of Sentinel-1 data for hydrologic simulations by assimilating the radar observations into GEOS-5, either separately from or simultaneously with SMAP radiometer observations. The assimilation can be performed if either or both Sentinel-1 or SMAP observations are available, and is thus not restricted to synchronised overpasses. To facilitate the assimilation of the radar observations, GEOS-5 is coupled to the water cloud model, simulating the radar backscatter as observed by Sentinel-1. The innovations, i.e. differences between observations and simulations, are converted into increments to the model soil moisture state through an Ensemble Kalman Filter. The model runs are performed at 9-km spatial and 3-hourly temporal resolution, over the period from May 2015 to October 2016. The impact of the assimilation on surface and root-zone soil moisture simulations is assessed using in situ measurements from SMAP core validation sites and sparse networks. The assimilation of Sentinel-1 backscatter is found to consistently improve surface and root-zone soil moisture, relative to the open loop (no assimilation). However

Significance of MPEG-7 textural features for improved mass detection in mammography.

PubMed

Eltonsy, Nevine H; Tourassi, Georgia D; Fadeev, Aleksey; Elmaghraby, Adel S

2006-01-01

The purpose of the study is to investigate the significance of MPEG-7 textural features for improving the detection of masses in screening mammograms. The detection scheme was originally based on morphological directional neighborhood features extracted from mammographic regions of interest (ROIs). Receiver Operating Characteristics (ROC) was performed to evaluate the performance of each set of features independently and merged into a back-propagation artificial neural network (BPANN) using the leave-one-out sampling scheme (LOOSS). The study was based on a database of 668 mammographic ROIs (340 depicting cancer regions and 328 depicting normal parenchyma). Overall, the ROC area index of the BPANN using the directional morphological features was Az=0.85+/-0.01. The MPEG-7 edge histogram descriptor-based BPNN showed an ROC area index of Az=0.71+/-0.01 while homogeneous textural descriptors using 30 and 120 channels helped the BPNN achieve similar ROC area indexes of Az=0.882+/-0.02 and Az=0.877+/-0.01 respectively. After merging the MPEG-7 homogeneous textural features with the directional neighborhood features the performance of the BPANN increased providing an ROC area index of Az=0.91+/-0.01. MPEG-7 homogeneous textural descriptor significantly improved the morphology-based detection scheme.

Histone deacetylase inhibitor significantly improved the cloning efficiency of porcine somatic cell nuclear transfer embryos.

PubMed

Huang, Yongye; Tang, Xiaochun; Xie, Wanhua; Zhou, Yan; Li, Dong; Yao, Chaogang; Zhou, Yang; Zhu, Jianguo; Lai, Liangxue; Ouyang, Hongsheng; Pang, Daxin

2011-12-01

Valproic acid (VPA), a histone deacetylase inbibitor, has been shown to generate inducible pluripotent stem (iPS) cells from mouse and human fibroblasts with a significant higher efficiency. Because successful cloning by somatic cell nuclear transfer (SCNT) undergoes a full reprogramming process in which the epigenetic state of a differentiated donor nuclear is converted into an embryonic totipotent state, we speculated that VPA would be useful in promoting cloning efficiency. Therefore, in the present study, we examined whether VPA can promote the developmental competence of SCNT embryos by improving the reprogramming state of donor nucleus. Here we report that 1 mM VPA for 14 to 16 h following activation significantly increased the rate of blastocyst formation of porcine SCNT embryos constructed from Landrace fetal fibroblast cells compared to the control (31.8 vs. 11.4%). However, we found that the acetylation level of Histone H3 lysine 14 and Histone H4 lysine 5 and expression level of Oct4, Sox2, and Klf4 was not significantly changed between VPA-treated and -untreated groups at the blastocyst stage. The SCNT embryos were transferred to 38 surrogates, and the cloning efficiency in the treated group was significantly improved compared with the control group. Taken together, we have demonstrated that VPA can improve both in vitro and in vivo development competence of porcine SCNT embryos.

Ceramic Composite Intermediate Temperature Stress-Rupture Properties Improved Significantly

NASA Technical Reports Server (NTRS)

Morscher, Gregory N.; Hurst, Janet B.

2002-01-01

Silicon carbide (SiC) composites are considered to be potential materials for future aircraft engine parts such as combustor liners. It is envisioned that on the hot side (inner surface) of the combustor liner, composites will have to withstand temperatures in excess of 1200 C for thousands of hours in oxidizing environments. This is a severe condition; however, an equally severe, if not more detrimental, condition exists on the cold side (outer surface) of the combustor liner. Here, the temperatures are expected to be on the order of 800 to 1000 C under high tensile stress because of thermal gradients and attachment of the combustor liner to the engine frame (the hot side will be under compressive stress, a less severe stress-state for ceramics). Since these composites are not oxides, they oxidize. The worst form of oxidation for strength reduction occurs at these intermediate temperatures, where the boron nitride (BN) interphase oxidizes first, which causes the formation of a glass layer that strongly bonds the fibers to the matrix. When the fibers strongly bond to the matrix or to one another, the composite loses toughness and strength and becomes brittle. To increase the intermediate temperature stress-rupture properties, researchers must modify the BN interphase. With the support of the Ultra-Efficient Engine Technology (UEET) Program, significant improvements were made as state-of-the-art SiC/SiC composites were developed during the Enabling Propulsion Materials (EPM) program. Three approaches were found to improve the intermediate-temperature stress-rupture properties: fiber-spreading, high-temperature silicon- (Si) doped boron nitride (BN), and outside-debonding BN.

Improved ACE-FTS observations of carbon tetrachloride (CCl4)

NASA Astrophysics Data System (ADS)

Harrison, Jeremy; Chipperfield, Martyn; Boone, Chris; Bernath, Peter

2016-04-01

The Atmospheric Chemistry Experiment Fourier transform spectrometer (ACE-FTS), on board the SCISAT satellite, has been recording solar occultation spectra through the Earth's atmosphere since 2004 and continues to take measurements with only minor loss in performance. ACE-FTS time series are available for a range of chlorine 'source' gases, including CCl3F (CFC-11), CCl2F2 (CFC-12), CHF2Cl (HCFC-22), CH3Cl and CCl4. Recently there has been much community interest in carbon tetrachloride (CCl4), a substance regulated by the Montreal Protocol because it leads to the catalytic destruction of stratospheric ozone. Estimated sources and sinks of CCl4 remain inconsistent with observations of its abundance. Satellite observations of CCl4 in the stratosphere are particularly useful in validating stratospheric loss (photolysis) rates; in fact the atmospheric loss of CCl4 is essentially all due to photolysis in the stratosphere. However, the latest ACE-FTS v3.5 CCl4 retrieval is biased high by ˜ 20-30%. A new ACE-FTS retrieval scheme utilising new laboratory spectroscopic measurements of CCl4 and improved microwindow selection has recently been developed. This improves upon the v3.5 retrieval and resolves the issue of the high bias; this new scheme will form the basis for the upcoming v4 processing version of ACE-FTS data. This presentation will outline the improvements made in the retrieval, and a subset of data will be compared with modelled CCl4 distributions from SLIMCAT, a state-of-the-art three-dimensional chemical transport model. The use of ACE-FTS data to evaluate the modelled stratospheric loss rate of CCl4 will also be discussed. The evaluated model, which also includes a treatment of surface soil and ocean sinks, will then be used to quantify current uncertainties in the global budget of CCl4.

Improvements to the OMI Near-uv Aerosol Algorithm Using A-train CALIOP and AIRS Observations

NASA Technical Reports Server (NTRS)

Torres, O.; Ahn, C.; Zhong, C.

2014-01-01

The height of desert dust and carbonaceous aerosols layers and, to a lesser extent, the difficulty in assessing the predominant size mode of these absorbing aerosol types, are sources of uncertainty in the retrieval of aerosol properties from near UV satellite observations. The availability of independent, near-simultaneous measurements of aerosol layer height, and aerosol-type related parameters derived from observations by other A-train sensors, makes possible the direct use of these parameters as input to the OMI (Ozone Monitoring Instrument) near UV retrieval algorithm. A monthly climatology of aerosol layer height derived from observations by the CALIOP (Cloud-Aerosol Lidar with Orthogonal Polarization) sensor, and real-time AIRS (Atmospheric Infrared Sounder) CO observations are used in an upgraded version of the OMI near UV aerosol algorithm. AIRS CO measurements are used as a reliable tracer of carbonaceous aerosols, which allows the identification of smoke layers in areas and times of the year where the dust-smoke differentiation is difficult in the near-UV. The use of CO measurements also enables the identification of elevated levels of boundary layer pollution undetectable by near UV observations alone. In this paper we discuss the combined use of OMI, CALIOP and AIRS observations for the characterization of aerosol properties, and show a significant improvement in OMI aerosol retrieval capabilities.

Observations of Academic Instruction for Students with Significant Intellectual Disability: Three States, Thirty-Nine Classrooms, One View

ERIC Educational Resources Information Center

Restorff, Diane E.; Abery, Brian H.

2013-01-01

As part of the validation process for alternate assessments, 39 classroom observations were conducted to gather data about current practices in providing academic instruction to students with significant intellectual disability. Using a standardized protocol, data were gathered using direct instructional observation, an Individualized Education…

Peer Observation: Improvement of Teaching Effectiveness through Class Participation at a Polytechnic University

ERIC Educational Resources Information Center

Lowder, Loraine; Atiqulla, Mir; Colebeck, Donna; Das, Sandip; Karim, M. A.; Khalid, Adeel; Singh, Rajnish; Utschig, Tristan

2017-01-01

An important purpose of peer observation is to provide formative feedback that will improve classroom teaching and learning. Peer observation in higher education has both quality and developmental objectives. Kennesaw State University, formerly Southern Polytechnic State University, offers a voluntary "Teaching Partners Program" open to…

Aerodynamic Improvements of an Empty Timber Truck can Have the Potential of Significantly Reducing Fuel Consumption

NASA Astrophysics Data System (ADS)

Andersson, Magnus; Marashi, Seyedeh Sepideh; Karlsson, Matts

2012-11-01

In the present study, aerodynamic drag (AD) has been estimated for an empty and a fully loaded conceptual timber truck (TT) using Computational Fluid Dynamics (CFD). The increasing fuel prices have challenged heavy duty vehicle (HDV) manufactures to strive for better fuel economy, by e.g. utilizing drag reducing external devices. Despite this knowledge, the TT fleets seem to be left in the dark. Like HDV aerodynamics, similarities can be observed as a large low pressure wake is formed behind the tractor (unloaded) and downstream of the trailer (full load) thus generating AD. As TTs travel half the time without any cargo, focus on drag reduction is important. The full scaled TTs where simulated using the realizable k-epsilon model with grid adaption techniques for mesh independence. Our results indicate that a loaded TT reduces the AD significantly as both wake size and turbulence kinetic energy are lowered. In contrast to HDV the unloaded TTs have a much larger design space available for possible drag reducing devices, e.g. plastic wrapping and/or flaps. This conceptual CFD study has given an indication of the large AD difference between the unloaded and fully loaded TT, showing the potential for significant AD improvements.

Improved UT1 Predictions through Low-Latency VLBI Observations

DTIC Science & Technology

2010-03-14

J Geod (2010) 84:399–402 DOI 10.1007/s00190-010-0372-8 SHORT NOTE Improved UT1 predictions through low-latency VLBI observations Brian Luzum · Axel...polar motion and nutation on UT1 determinations from VLBI Intensive obser- vations. J Geod 82(12):863. doi:10.1007/s00190-008-0212-2 Ray JR, Carter WE...Behrend D (2007) The International VLBI Service for Geodesy and Astrometry (IVS): current capabilities and future prospects. J Geod 81(6–8):479. doi

The European Academy laparoscopic “Suturing Training and Testing’’ (SUTT) significantly improves surgeons’ performance

PubMed Central

Sleiman, Z.; Tanos, V.; Van Belle, Y.; Carvalho, J.L.; Campo, R.

2015-01-01

The efficiency of suturing training and testing (SUTT) model by laparoscopy was evaluated, measuring the suturingskill acquisition of trainee gynecologists at the beginning and at the end of a teaching course. During a workshop organized by the European Academy of Gynecological Surgery (EAGS), 25 participants with three different experience levels in laparoscopy (minor, intermediate and major) performed the 4 exercises of the SUTT model (Ex 1: both hands stitching and continuous suturing, Ex 2: right hand stitching and intracorporeal knotting, Ex 3: left hand stitching and intracorporeal knotting, Ex 4: dominant hand stitching, tissue approximation and intracorporeal knotting). The time needed to perform the exercises is recorded for each trainee and group and statistical analysis used to note the differences. Overall, all trainees achieved significant improvement in suturing time (p < 0.005) as measured before and after completion of the training. Similar significantly improved suturing time differences (p < 0.005) were noted among the groups of trainees with different laparoscopic experience. In conclusion a short well-guided training course, using the SUTT model, improves significantly surgeon’s laparoscopic suturing ability, independently of the level of experience in laparoscopic surgery. Key words: Endoscopy, laparoscopic suturing, psychomotor skills, surgery, teaching, training suturing model. PMID:26977264

Using aircraft and satellite observations to improve regulatory air quality models

NASA Astrophysics Data System (ADS)

Canty, T. P.; Vinciguerra, T.; Anderson, D. C.; Carpenter, S. F.; Goldberg, D. L.; Hembeck, L.; Montgomery, L.; Liu, X.; Salawitch, R. J.; Dickerson, R. R.

2014-12-01

Federal and state agencies rely on EPA approved models to develop attainment strategies that will bring states into compliance with the National Ambient Air Quality Standards (NAAQS). We will describe modifications to the Community Multi-Scale Air Quality (CMAQ) model and Comprehensive Air Quality Model with Extensions (CAMx) frameworks motivated by analysis of NASA satellite and aircraft measurements. Observations of tropospheric column NO2 from OMI have already led to the identification of an important deficiency in the chemical mechanisms used by models; data collected during the DISCOVER-AQ field campaign has been instrumental in devising an improved representation of the chemistry of nitrogen species. Our recent work has focused on the use of: OMI observations of tropospheric O3 to assess and improve the representation of boundary conditions used by AQ models, OMI NO2 to derive a top down NOx emission inventory from commercial shipping vessels that affect air quality in the Eastern U.S., and OMI HCHO to assess the C5H8 emission inventories provided by bioegenic emissions models. We will describe how these OMI-driven model improvements are being incorporated into the State Implementation Plans (SIPs) being prepared for submission to EPA in summer 2015 and how future modeling efforts may be impacted by our findings.

Multilevel biological characterization of exomic variants at the protein level significantly improves the identification of their deleterious effects.

PubMed

Raimondi, Daniele; Gazzo, Andrea M; Rooman, Marianne; Lenaerts, Tom; Vranken, Wim F

2016-06-15

There are now many predictors capable of identifying the likely phenotypic effects of single nucleotide variants (SNVs) or short in-frame Insertions or Deletions (INDELs) on the increasing amount of genome sequence data. Most of these predictors focus on SNVs and use a combination of features related to sequence conservation, biophysical, and/or structural properties to link the observed variant to either neutral or disease phenotype. Despite notable successes, the mapping between genetic variants and their phenotypic effects is riddled with levels of complexity that are not yet fully understood and that are often not taken into account in the predictions, despite their promise of significantly improving the prediction of deleterious mutants. We present DEOGEN, a novel variant effect predictor that can handle both missense SNVs and in-frame INDELs. By integrating information from different biological scales and mimicking the complex mixture of effects that lead from the variant to the phenotype, we obtain significant improvements in the variant-effect prediction results. Next to the typical variant-oriented features based on the evolutionary conservation of the mutated positions, we added a collection of protein-oriented features that are based on functional aspects of the gene affected. We cross-validated DEOGEN on 36 825 polymorphisms, 20 821 deleterious SNVs, and 1038 INDELs from SwissProt. The multilevel contextualization of each (variant, protein) pair in DEOGEN provides a 10% improvement of MCC with respect to current state-of-the-art tools. The software and the data presented here is publicly available at http://ibsquare.be/deogen : wvranken@vub.ac.be Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Evaluating an Art-Based Intervention to Improve Practicing Nurses' Observation, Description, and Problem Identification Skills.

PubMed

Nease, Beth M; Haney, Tina S

Astute observation, description, and problem identification skills provide the underpinning for nursing assessment, surveillance, and prevention of failure to rescue events. Art-based education has been effective in nursing schools for improving observation, description, and problem identification. The authors describe a randomized controlled pilot study testing the effectiveness of an art-based educational intervention aimed at improving these skills in practicing nurses.

Evaluation and Improvement of Polar WRF simulations using the observed atmospheric profiles in the Arctic seasonal ice zone

NASA Astrophysics Data System (ADS)

Liu, Z.; Schweiger, A. J. B.

2016-12-01

We use the Polar Weather Research and Forecasting (WRF) model to simulate atmospheric conditions during the Seasonal Ice Zone Reconnaissance Survey (SIZRS) over the Beaufort Sea in the summer since 2013. With the 119 SIZRS dropsondes in the18 cross sections along the 150W and 140W longitude lines, we evaluate the performance of WRF simulations and two forcing data sets, the ERA-Interim reanalysis and the Global Forecast System (GFS) analysis, and explore the improvement of the Polar WRF performance when the dropsonde data are assimilated using observation nudging. Polar WRF, ERA-Interim, and GFS can reproduce the general features of the observed mean atmospheric profiles, such as low-level temperature inversion, low-level jet (LLJ) and specific humidity inversion. The Polar WRF significantly improves the mean LLJ, with a lower and stronger jet and a larger turning angle than the forcing, which is likely related to the lower values of the boundary layer diffusion in WRF than in the global models such as ECMWF and GFS. The Polar WRF simulated relative humidity closely resembles the forcing datasets while having large biases compared to observations. This suggests that the performance of Polar WRF and its forecasts in this region are limited by the quality of the forcing dataset and that the assimilation of more and better-calibrated observations, such as humidity data, is critical for their improvement. We investigate the potential of assimilating the SIZRS dropsonde dataset in improving the weather forecast over the Beaufort Sea. A simple local nudging approach is adopted. Along SIZRS flight cross sections, a set of Polar WRF simulations are performed with varying number of variables and dropsonde profiles assimilated. Different model physics are tested to examine the sensitivity of different aspects of model physics, such as boundary layer schemes, cloud microphysics, and radiation parameterization, to data assimilation. The comparison of the Polar WRF runs with

Improved Space Object Observation Techniques Using CMOS Detectors

NASA Astrophysics Data System (ADS)

Schildknecht, T.; Hinze, A.; Schlatter, P.; Silha, J.; Peltonen, J.; Santti, T.; Flohrer, T.

2013-08-01

CMOS-sensors, or in general Active Pixel Sensors (APS), are rapidly replacing CCDs in the consumer camera market. Due to significant technological advances during the past years these devices start to compete with CCDs also for demanding scientific imaging applications, in particular in the astronomy community. CMOS detectors offer a series of inherent advantages compared to CCDs, due to the structure of their basic pixel cells, which each contain their own amplifier and readout electronics. The most prominent advantages for space object observations are the extremely fast and flexible readout capabilities, feasibility for electronic shuttering and precise epoch registration, and the potential to perform image processing operations on-chip and in real-time. Presently applied and proposed optical observation strategies for space debris surveys and space surveillance applications had to be analyzed. The major design drivers were identified and potential benefits from using available and future CMOS sensors were assessed. The major challenges and design drivers for ground-based and space-based optical observation strategies have been analyzed. CMOS detector characteristics were critically evaluated and compared with the established CCD technology, especially with respect to the above mentioned observations. Similarly, the desirable on-chip processing functionalities which would further enhance the object detection and image segmentation were identified. Finally, the characteristics of a particular CMOS sensor available at the Zimmerwald observatory were analyzed by performing laboratory test measurements.

Optical properties of volcanic ash: improving remote sensing observations.

NASA Astrophysics Data System (ADS)

Whelley, Patrick; Colarco, Peter; Aquila, Valentina; Krotkov, Nickolay; Bleacher, Jake; Garry, Brent; Young, Kelsey; Rocha Lima, Adriana; Martins, Vanderlei; Carn, Simon

2016-04-01

Many times each year explosive volcanic eruptions loft ash into the atmosphere. Global travel and trade rely on aircraft vulnerable to encounters with airborne ash. Volcanic ash advisory centers (VAACs) rely on dispersion forecasts and satellite data to issue timely warnings. To improve ash forecasts model developers and satellite data providers need realistic information about volcanic ash microphysical and optical properties. In anticipation of future large eruptions we can study smaller events to improve our remote sensing and modeling skills so when the next Pinatubo 1991 or larger eruption occurs, ash can confidently be tracked in a quantitative way. At distances >100km from their sources, drifting ash plumes, often above meteorological clouds, are not easily detected from conventional remote sensing platforms, save deriving their quantitative characteristics, such as mass density. Quantitative interpretation of these observations depends on a priori knowledge of the spectral optical properties of the ash in UV (>0.3μm) and TIR wavelengths (>10μm). Incorrect assumptions about the optical properties result in large errors in inferred column mass loading and size distribution, which misguide operational ash forecasts. Similarly, simulating ash properties in global climate models also requires some knowledge of optical properties to improve aerosol speciation.

Observing the operational significance of discord consumption

NASA Astrophysics Data System (ADS)

Gu, Mile; Chrzanowski, Helen M.; Assad, Syed M.; Symul, Thomas; Modi, Kavan; Ralph, Timothy C.; Vedral, Vlatko; Lam, Ping Koy

2012-09-01

Coherent interactions that generate negligible entanglement can still exhibit unique quantum behaviour. This observation has motivated a search beyond entanglement for a complete description of all quantum correlations. Quantum discord is a promising candidate. Here, we demonstrate that under certain measurement constraints, discord between bipartite systems can be consumed to encode information that can only be accessed by coherent quantum interactions. The inability to access this information by any other means allows us to use discord to directly quantify this `quantum advantage'. We experimentally encode information within the discordant correlations of two separable Gaussian states. The amount of extra information recovered by coherent interaction is quantified and directly linked with the discord consumed during encoding. No entanglement exists at any point of this experiment. Thus we introduce and demonstrate an operational method to use discord as a physical resource.

Tunable laser techniques for improving the precision of observational astronomy

NASA Astrophysics Data System (ADS)

Cramer, Claire E.; Brown, Steven W.; Lykke, Keith R.; Woodward, John T.; Bailey, Stephen; Schlegel, David J.; Bolton, Adam S.; Brownstein, Joel; Doherty, Peter E.; Stubbs, Christopher W.; Vaz, Amali; Szentgyorgyi, Andrew

2012-09-01

Improving the precision of observational astronomy requires not only new telescopes and instrumentation, but also advances in observing protocols, calibrations and data analysis. The Laser Applications Group at the National Institute of Standards and Technology in Gaithersburg, Maryland has been applying advances in detector metrology and tunable laser calibrations to problems in astronomy since 2007. Using similar measurement techniques, we have addressed a number of seemingly disparate issues: precision flux calibration for broad-band imaging, precision wavelength calibration for high-resolution spectroscopy, and precision PSF mapping for fiber spectrographs of any resolution. In each case, we rely on robust, commercially-available laboratory technology that is readily adapted to use at an observatory. In this paper, we give an overview of these techniques.

Improving Global Analysis and Short-Range Forecast Using Rainfall and Moisture Observations Derived from TRMM and SSM/I Passive Microwave Instruments

NASA Technical Reports Server (NTRS)

Hou, Arthur Y.; Zhang, Sara Q.; daSilva, Arlindo M.; Olson, William S.; Kummerow, Christian D.; Simpson, Joanne

2000-01-01

The Global Precipitation Mission, a satellite project under consideration as a follow-on to the Tropical Rainfall Measuring Mission (TRMM) by the National Aeronautics and Space Agency (NASA) in the United States, the National Space Development Agency (NASDA) in Japan, and other international partners, comprises an improved TRMM-like satellite and a constellation of 8 satellites carrying passive microwave radiometers to provide global rainfall measurements at 3-hour intervals. The success of this concept relies on the merits of rainfall estimates derived from passive microwave radiometers. This article offers a proof-of-concept demonstration of the benefits of using, rainfall and total precipitable water (TPW) information derived from such instruments in global data assimilation with observations from the TRMM Microwave Imager (TMI) and 2 Special Sensor Microwave/Imager (SSM/I) instruments. Global analyses that optimally combine observations from diverse sources with physical models of atmospheric and land processes can provide a comprehensive description of the climate systems. Currently, such data analyses contain significant errors in primary hydrological fields such as precipitation and evaporation, especially in the tropics. We show that assimilating the 6-h averaged TMI and SSM/I surface rainrate and TPW retrievals improves not only the hydrological cycle but also key climate parameters such as clouds, radiation, and the upper tropospheric moisture in the analysis produced by the Goddard Earth Observing System (GEOS) Data Assimilation System, as verified against radiation measurements by the Clouds and the Earth's Radiant Energy System (CERES) instrument and brightness temperature observations by the TIROS Operational Vertical Sounder (TOVS) instruments. Typically, rainfall assimilation improves clouds and radiation in areas of active convection, as well as the latent heating and large-scale motions in the tropics, while TPW assimilation leads to reduced

Zebularine and scriptaid significantly improve epigenetic reprogramming of yak fibroblasts and cloning efficiency.

PubMed

Xiong, Xianrong; Lan, Daoliang; Li, Jian; Zhong, Jincheng; Zi, Xiangdong; Ma, Li; Wang, Yong

2013-08-01

Abnormal epigenetic reprogramming of the donor nucleus after somatic cell nuclear transfer (SCNT) is thought to be the main cause of low cloning efficiency. Following SCNT, the donor nucleus often fails to express early embryonic genes and establish a normal embryonic pattern of chromatin modification. Therefore, in this study, we have attempted to improve epigenetic reprogramming of the donor nucleus and cloned embryos with Zebularine and Scriptaid. Yak fibroblasts were treated with 20 μM Zebularine alone or 20 μM Zebularine plus 0.5 μM Scriptaid for 24 h, whereas yak cloned embryos were treated exclusively with 0.5 μM Scriptaid for 12 h. There was no effect on cellular viability and proliferation after drug treatment. The treatment of fibroblasts with Zebularine or Zebularine plus Scriptaid increased histone acetylation of histone 3 lysine 9 (H3K9), but decreased the level of DNA methylation of Oct-4 and Sox-2 promoter regions. When donor cells were used after Zebularine plus Scriptaid treatment to reconstruct cloned embryos and then treated with Scriptaid, the developmental competence and cryosurvival of embryos were improved significantly. In addition, the relative expression of Oct-4 and Sox-2 were increased significantly. The expression levels of Dnmt-1 and Hdac-1 were significantly decreased when fibroblasts and cloned embryos were treated with Zebularine or Scriptaid. This work provides functional evidence that treatment with Zebularine and Scriptaid modifies the epigenetic status of yak fibroblasts, subsequently enhancing in vitro developmental potential and the quality of yak cloned embryos.

Surgically-Induced Weight Loss Significantly Improves Nonalcoholic Fatty Liver Disease and the Metabolic Syndrome

PubMed Central

Mattar, Samer G.; Velcu, Laura M.; Rabinovitz, Mordechai; Demetris, A J.; Krasinskas, A M.; Barinas-Mitchell, Emma; Eid, George M.; Ramanathan, Ramesh; Taylor, Debra S.; Schauer, Philip R.

2005-01-01

Objective: To evaluate the effects of surgical weight loss on fatty liver disease in severely obese patients. Summary Background Data: Nonalcoholic fatty liver disease (NAFLD), a spectrum that extends to liver fibrosis and cirrhosis, is rising at an alarming rate. This increase is occurring in conjunction with the rise of severe obesity and is probably mediated in part by metabolic syndrome (MS). Surgical weight loss operations, probably by reversing MS, have been shown to result in improvement in liver histology. Methods: Patients who underwent laparoscopic surgical weight loss operations from March 1999 through August 2004, and who agreed to have an intraoperative liver biopsy followed by at least one postoperative liver biopsy, were included. Results: There were 70 patients who were eligible. All patients underwent laparoscopic operations, the majority being laparoscopic Roux-en-Y gastric bypass. The mean excess body weight loss at time of second biopsy was 59% ± 22% and the time interval between biopsies was 15 ± 9 months. There was a reduction in prevalence of metabolic syndrome, from 70% to 14% (P < 0.001), and a marked improvement in liver steatosis (from 88% to 8%), inflammation (from 23% to 2%), and fibrosis (from 31% to 13%; all P < 0.001). Inflammation and fibrosis resolved in 37% and 20% of patients, respectively, corresponding to improvement of 82% (P < 0.001) in grade and 39% (P < 0.001) in stage of liver disease. Conclusion: Surgical weight loss results in significant improvement of liver morphology in severely obese patients. These beneficial changes may be associated with a significant reduction in the prevalence of the metabolic syndrome. PMID:16192822

Acquisition and improvement of human motor skills: Learning through observation and practice

NASA Technical Reports Server (NTRS)

Iba, Wayne

1991-01-01

Skilled movement is an integral part of the human existence. A better understanding of motor skills and their development is a prerequisite to the construction of truly flexible intelligent agents. We present MAEANDER, a computational model of human motor behavior, that uniformly addresses both the acquisition of skills through observation and the improvement of skills through practice. MAEANDER consists of a sensory-effector interface, a memory of movements, and a set of performance and learning mechanisms that let it recognize and generate motor skills. The system initially acquires such skills by observing movements performed by another agent and constructing a concept hierarchy. Given a stored motor skill in memory, MAEANDER will cause an effector to behave appropriately. All learning involves changing the hierarchical memory of skill concepts to more closely correspond to either observed experience or to desired behaviors. We evaluated MAEANDER empirically with respect to how well it acquires and improves both artificial movement types and handwritten script letters from the alphabet. We also evaluate MAEANDER as a psychological model by comparing its behavior to robust phenomena in humans and by considering the richness of the predictions it makes.

Pluto: improved astrometry from 19 years of observations

NASA Astrophysics Data System (ADS)

Benedetti-Rossi, G.; Vieira Martins, R.; Camargo, J. I. B.; Assafin, M.; Braga-Ribas, F.

2014-10-01

Context. We present astrometric positions of Pluto, consistent with the International Celestial Reference System, from 4412 CCD frames observed over 120 nights with three telescopes at the Observatório do Pico dos Dias in Brazil, covering a time span from 1995 to 2013, and also 145 frames observed over 11 nights in 2007 and 2009 with the ESO/MPG 2.2m telescope equipped with the Wide Field Imager (WFI). Aims: Our aim is to contribute to the study and improvement of the orbit of Pluto with new astrometric methods and positions. Methods: All astrometric positions of Pluto were reduced with the Platform for Reduction of Astronomical Images Automatically (PRAIA), using the USNO CCD Astrograph Catalogue 4 (UCAC4) as the reference catalog. We also used the planetary ephemeris DE421+plu021 for comparisons. The positions were corrected for differential chromatic refraction. The (x, y) center of Pluto was determined from corrections to the measured photocenter, which was contaminated by Charon. The corrections were obtained with an original procedure based on analytical expressions derived from a two-dimensional Gaussian function i.e. the point spread function PSF fitted to the images to derive the (x, y) measurements. Results: We obtained mean values of 4 mas and 37 mas for right ascension and declination, and standard deviations of σα = 45 mas and σδ = 49 mas, for the offsets in the sense observed minus ephemeris position, after the corrections. We confirm the presence of a linear drift in the ephemeris declinations from 2005 on, also obtained from stellar occultations. Conclusions: We present astrometric positions of Pluto for 19 years of observations in Brazil. The positions, corrected for differential chromatic refraction and Pluto/Charon photocenter effects, presented the same behavior as obtained from stellar occultations, with a drift in declinations of about 100 mas since 2005. The results indicate that the DE421 Pluto ephemeris used in this work need to be

Significant improvement in one-dimensional cursor control using Laplacian electroencephalography over electroencephalography

NASA Astrophysics Data System (ADS)

Boudria, Yacine; Feltane, Amal; Besio, Walter

2014-06-01

Objective. Brain-computer interfaces (BCIs) based on electroencephalography (EEG) have been shown to accurately detect mental activities, but the acquisition of high levels of control require extensive user training. Furthermore, EEG has low signal-to-noise ratio and low spatial resolution. The objective of the present study was to compare the accuracy between two types of BCIs during the first recording session. EEG and tripolar concentric ring electrode (TCRE) EEG (tEEG) brain signals were recorded and used to control one-dimensional cursor movements. Approach. Eight human subjects were asked to imagine either ‘left’ or ‘right’ hand movement during one recording session to control the computer cursor using TCRE and disc electrodes. Main results. The obtained results show a significant improvement in accuracies using TCREs (44%-100%) compared to disc electrodes (30%-86%). Significance. This study developed the first tEEG-based BCI system for real-time one-dimensional cursor movements and showed high accuracies with little training.

New Fixed-Dose Combinations of Fenofibrate/Simvastatin Therapy Significantly Improve the Lipid Profile of High-Risk Patients with Mixed Dyslipidemia Versus Monotherapies.

PubMed

Foucher, Christelle; Aubonnet, Patrick; Reichert, Petr; Berli, Mario; Schaeffer, Axel; Calvo Vargas, Cesar Gonzalo; Lochocka, Anna; Belenky, Dmitry; Koch, Hans-Friedrich

2015-12-01

Guidelines propose additional therapy to statin to treat elevated triglycerides (TG) and low high-density lipoprotein cholesterol (HDLC) in dyslipidemic patients. We evaluated the effects of new fixed-dose combinations (FDC) of fenofibrate/simvastatin on plasma lipids versus simvastatin or fenofibrate monotherapies. Subjects with mixed dyslipidemia at high or very high cardiovascular risk on stable statin therapy for at least 3 months were included in a randomized, double-blind, active-control, parallel-group study. Patients were treated with FDC fenofibrate/simvastatin 145/20 mg or 145/40 mg, simvastatin 20 mg or 40 mg, or fenofibrate 145 mg for 12 weeks. Plasma lipids, C-reactive protein, and cystatin C were measured before and after treatments. Differences in % changes were compared between FDC fenofibrate/simvastatin and monotherapies. Significant differences between FDC fenofibrate/simvastatin and simvastatin monotherapies were observed for the % change of TG (LS mean difference [two-sided 95% CI]: -32.2% [-38.6%, -25.8%], P < 0.001) and HDL-C (7.5% [4.7%, 10.2%], P < 0.001). A significant difference between the FDC fenofibrate/simvastatin and fenofibrate was observed for LDLC % changes (-34.7% [-40.8%, -28.5%], P < 0.001). Significant differences between FDC fenofibrate/simvastatin and their respective monotherapies were also observed for Apo B and non-HDLC % changes. The FDC were well tolerated with a similar safety profile compared with monotherapies. FDC fenofibrate/simvastatin are effective and well-tolerated therapies to improve the TG and HDLC profile in high-risk patients with mixed dyslipidemia. © 2015 John Wiley & Sons Ltd.

PXD101 significantly improves nuclear reprogramming and the in vitro developmental competence of porcine SCNT embryos

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jin, Jun-Xue; Kang, Jin-Dan; Li, Suo

2015-01-02

Highlights: • First explored that the effects of PXD101 on the development of SCNT embryos in vitro. • 0.5 μM PXD101 treated for 24 h improved the development of porcine SCNT embryos. • Level of AcH3K9 was significantly higher than control group at early stages. - Abstract: In this study, we investigated the effects of the histone deacetylase inhibitor PXD101 (belinostat) on the preimplantation development of porcine somatic cell nuclear transfer (SCNT) embryos and their expression of the epigenetic markers histone H3 acetylated at lysine 9 (AcH3K9). We compared the in vitro developmental competence of SCNT embryos treated with variousmore » concentrations of PXD101 for 24 h. Treatment with 0.5 μM PXD101 significantly increased the proportion of SCNT embryos that reached the blastocyst stage, in comparison to the control group (23.3% vs. 11.5%, P < 0.05). We tested the in vitro developmental competence of SCNT embryos treated with 0.5 μM PXD101 for various amounts of times following activation. Treatment for 24 h significantly improved the development of porcine SCNT embryos, with a significantly higher proportion of embryos reaching the blastocyst stage in comparison to the control group (25.7% vs. 10.6%, P < 0.05). PXD101-treated SCNT embryos were transferred into two surrogate sows, one of whom became pregnant and four fetuses developed. PXD101 treatment significantly increased the fluorescence intensity of immunostaining for AcH3K9 in embryos at the pseudo-pronuclear and 2-cell stages. At these stages, the fluorescence intensities of immunostaining for AcH3K9 were significantly higher in PXD101-treated embryos than in control untreated embryos. In conclusion, this study demonstrates that PXD101 can significantly improve the in vitro and in vivo developmental competence of porcine SCNT embryos and can enhance their nuclear reprogramming.« less

Brief Communication: Upper Air Relaxation in RACMO2 Significantly Improves Modelled Interannual Surface Mass Balance Variability in Antarctica

NASA Technical Reports Server (NTRS)

van de Berg, W. J.; Medley, B.

2016-01-01

The Regional Atmospheric Climate Model (RACMO2) has been a powerful tool for improving surface mass balance (SMB) estimates from GCMs or reanalyses. However, new yearly SMB observations for West Antarctica show that the modelled interannual variability in SMB is poorly simulated by RACMO2, in contrast to ERA-Interim, which resolves this variability well. In an attempt to remedy RACMO2 performance, we included additional upper-air relaxation (UAR) in RACMO2. With UAR, the correlation to observations is similar for RACMO2 and ERA-Interim. The spatial SMB patterns and ice-sheet-integrated SMB modelled using UAR remain very similar to the estimates of RACMO2 without UAR. We only observe an upstream smoothing of precipitation in regions with very steep topography like the Antarctic Peninsula. We conclude that UAR is a useful improvement for regional climate model simulations, although results in regions with steep topography should be treated with care.

Improving Factor Score Estimation Through the Use of Observed Background Characteristics

PubMed Central

Curran, Patrick J.; Cole, Veronica; Bauer, Daniel J.; Hussong, Andrea M.; Gottfredson, Nisha

2016-01-01

A challenge facing nearly all studies in the psychological sciences is how to best combine multiple items into a valid and reliable score to be used in subsequent modelling. The most ubiquitous method is to compute a mean of items, but more contemporary approaches use various forms of latent score estimation. Regardless of approach, outside of large-scale testing applications, scoring models rarely include background characteristics to improve score quality. The current paper used a Monte Carlo simulation design to study score quality for different psychometric models that did and did not include covariates across levels of sample size, number of items, and degree of measurement invariance. The inclusion of covariates improved score quality for nearly all design factors, and in no case did the covariates degrade score quality relative to not considering the influences at all. Results suggest that the inclusion of observed covariates can improve factor score estimation. PMID:28757790

Merging Station Observations with Large-Scale Gridded Data to Improve Hydrological Predictions over Chile

NASA Astrophysics Data System (ADS)

Peng, L.; Sheffield, J.; Verbist, K. M. J.

2016-12-01

Hydrological predictions at regional-to-global scales are often hampered by the lack of meteorological forcing data. The use of large-scale gridded meteorological data is able to overcome this limitation, but these data are subject to regional biases and unrealistic values at local scale. This is especially challenging in regions such as Chile, where climate exhibits high spatial heterogeneity as a result of long latitude span and dramatic elevation changes. However, regional station-based observational datasets are not fully exploited and have the potential of constraining biases and spatial patterns. This study aims at adjusting precipitation and temperature estimates from the Princeton University global meteorological forcing (PGF) gridded dataset to improve hydrological simulations over Chile, by assimilating 982 gauges from the Dirección General de Aguas (DGA). To merge station data with the gridded dataset, we use a state-space estimation method to produce optimal gridded estimates, considering both the error of the station measurements and the gridded PGF product. The PGF daily precipitation, maximum and minimum temperature at 0.25° spatial resolution are adjusted for the period of 1979-2010. Precipitation and temperature gauges with long and continuous records (>70% temporal coverage) are selected, while the remaining stations are used for validation. The leave-one-out cross validation verifies the robustness of this data assimilation approach. The merged dataset is then used to force the Variable Infiltration Capacity (VIC) hydrological model over Chile at daily time step which are compared to the observations of streamflow. Our initial results show that the station-merged PGF precipitation effectively captures drizzle and the spatial pattern of storms. Overall the merged dataset has significant improvements compared to the original PGF with reduced biases and stronger inter-annual variability. The invariant spatial pattern of errors between the station

Observational study: daily treatment with a new compound “tradamixina” plus serenoa repens for two months improved the lower urinary tract symptoms

PubMed Central

2012-01-01

Background Lower urinary tract symptoms (LUTS) are associated with great emotional costs to individuals and substantial economic costs to society. This study seeks to evaluate the effect of a new natural compound “Tradamixina plus Serenoa Repens” in order to improve lower urinary tract symptoms. Methods 100 patients (≥45years) who had had LUTS/BPH for >6 mo at screening and with IPSS -The international Prostate symptom scores- ≥13 and maximum urinary flow rate (Qmax) ≥4 to ≤15 ml/s. were recruited. The compound “Tradamixina plus Serenoa Repens” (80 mg of Alga Ecklonia Bicyclis, 100 mg of Tribulus Terrestris and 100 mg of D-Glucosamine and N-Acetyl-D-Glucosamine plus 320 mg of Serenoa Repens) was administered daily for 2 months. At visit and after 60 days of treatment patients were evaluated by means of detailed medical urological history, clinical examination, laboratory investigations (total PSA), and instrumental examination like urolfowmetry. Efficacy measures included IPSS-International Prostate Sympto, BPH Impact Index (BII), Quality-of-Life (QoL) Index. Measures were assessed at baseline and end point (12 wk or end of therapy) and also at screening, 1 and 4 wk for IPSS, and 4 wk for BII. Statistical significance was interpreted only if the results of the preceding analysis were significant at the 0.05 level. Results After 2 months of treatment the change from baseline to week 12 relative to “Tradamixina plus Seronea Repens” in total IPSS and Qol was statistically significant. Differences from baseline in BII were statistically significant for “Tradamixina plus Seronea Repens” above all differences in BII were also significant at 4 wk (LSmean ± SE: -0.8 ± 0.2). In the distribution of subjects over the PGI-I and CGI-I response categories were significant for”Tradamixina plus Seronea Repens” (PGI-I: p = 0.001; CGI-I). We also observed a decrease of total PSA. Conclusion The daily treatment with a new compound “Tradamixina plus

The effectiveness of research-based physics learning module with predict-observe-explain strategies to improve the student’s competence

NASA Astrophysics Data System (ADS)

Usmeldi

2018-05-01

The preliminary study shows that many students are difficult to master the concept of physics. There are still many students who have not mastery learning physics. Teachers and students still use textbooks. Students rarely do experiments in the laboratory. One model of learning that can improve students’ competence is a research-based learning with Predict- Observe-Explain (POE) strategies. To implement this learning, research-based physics learning modules with POE strategy are used. The research aims to find out the effectiveness of implementation of research-based physics learning modules with POE strategy to improving the students’ competence. The research used a quasi-experimental with pretest-posttest group control design. Data were collected using observation sheets, achievement test, skill assessment sheets, questionnaire of attitude and student responses to learning implementation. The results of research showed that research-based physics learning modules with POE strategy was effective to improve the students’ competence, in the case of (1) mastery learning of physics has been achieved by majority of students, (2) improving the students competency of experimental class including high category, (3) there is a significant difference between the average score of students’ competence of experimental class and the control class, (4) the average score of the students competency of experimental class is higher than the control class, (5) the average score of the students’ responses to the learning implementation is very good category, this means that most students can implement research-based learning with POE strategies.

A peptide-retrieval strategy enables significant improvement of quantitative performance without compromising confidence of identification.

PubMed

Tu, Chengjian; Shen, Shichen; Sheng, Quanhu; Shyr, Yu; Qu, Jun

2017-01-30

Reliable quantification of low-abundance proteins in complex proteomes is challenging largely owing to the limited number of spectra/peptides identified. In this study we developed a straightforward method to improve the quantitative accuracy and precision of proteins by strategically retrieving the less confident peptides that were previously filtered out using the standard target-decoy search strategy. The filtered-out MS/MS spectra matched to confidently-identified proteins were recovered, and the peptide-spectrum-match FDR were re-calculated and controlled at a confident level of FDR≤1%, while protein FDR maintained at ~1%. We evaluated the performance of this strategy in both spectral count- and ion current-based methods. >60% increase of total quantified spectra/peptides was respectively achieved for analyzing a spike-in sample set and a public dataset from CPTAC. Incorporating the peptide retrieval strategy significantly improved the quantitative accuracy and precision, especially for low-abundance proteins (e.g. one-hit proteins). Moreover, the capacity of confidently discovering significantly-altered proteins was also enhanced substantially, as demonstrated with two spike-in datasets. In summary, improved quantitative performance was achieved by this peptide recovery strategy without compromising confidence of protein identification, which can be readily implemented in a broad range of quantitative proteomics techniques including label-free or labeling approaches. We hypothesize that more quantifiable spectra and peptides in a protein, even including less confident peptides, could help reduce variations and improve protein quantification. Hence the peptide retrieval strategy was developed and evaluated in two spike-in sample sets with different LC-MS/MS variations using both MS1- and MS2-based quantitative approach. The list of confidently identified proteins using the standard target-decoy search strategy was fixed and more spectra/peptides with less

A modified culture method significantly improves the development of mouse somatic cell nuclear transfer embryos.

PubMed

Dai, Xiangpeng; Hao, Jie; Zhou, Qi

2009-08-01

Many strategies have been established to improve the efficiency of somatic cell nuclear transfer (SCNT), but relatively few focused on improving culture conditions. The effect of different culture media on preimplantation development of mouse nuclear transfer embryos was investigated. A modified sequential media method, named D media (M16/KSOM and CZB-EG/KSOM), was successfully established that significantly improves SCNT embryo development. Our result demonstrated that while lacking any adverse effect on in vivo fertilized embryos, the D media dramatically improves the blastocyst development of SCNT embryos compared with other commonly used media, including KSOM, M16, CZB, and alphaMEM. Specifically, the rate of blastocyst formation was 62.3% for D1 (M16/KSOM) versus 10-30% for the other media. An analysis of media components indicated that removing EDTA and glutamine from the media can be beneficial for early SCNT embryo development. Our results suggest that in vitro culture environment plays an important role in somatic cell reprogramming, and D media represent the most efficient culture method reported to date to support mouse SCNT early embryo development in vitro.

On the Reprocessing and Reanalysis of Observations for Climate

NASA Technical Reports Server (NTRS)

Bosilovich, Michael G.; Kennedy, John; Dee, Dick; Allan, R.; O'Neill, Alan

2013-01-01

The long observational record is critical to our understanding of the Earths climate, but most observing systems were not developed with a climate objective in mind. As a result, tremendous efforts have gone into assessing and reprocessing the data records to improve their usefulness in climate studies. The purpose of this paper is to both review recent progress in reprocessing and reanalyzing observations, and to summarize the challenges that must be overcome in order to improve our understanding of climate and variability. Reprocessing improves data quality through more scrutiny and improved retrieval techniques for individual observing systems, while reanalysis merges many disparate observations with models through data assimilation, yet both aim to provide an climatology of Earth processes. Many challenges remain, such as tracking the improvement of processing algorithms and limited spatial coverage. Reanalyses have fostered significant research, yet reliable global trends in many physical fields are not yet attainable, despite significant advances in data assimilation and numerical modeling. Oceanic reanalyses have made significant advances in recent years, but will only be discussed here in terms of progress toward integrated Earth system analyses. Climate data sets are generally adequate for process studies and large-scale climate variability. Communication of the strengths, limitations and uncertainties of reprocessed observations and reanalysis data, not only among the community of developers, but also with the extended research community, including the new generations of researchers and the decision makers is crucial for further advancement of the observational data records. It must be emphasized that careful investigation of the data and processing methods are required to use the observations appropriately.

Survival in pediatric medulloblastoma: a population-based observational study to improve prognostication.

PubMed

Weil, Alexander G; Wang, Anthony C; Westwick, Harrison J; Ibrahim, George M; Ariani, Rojine T; Crevier, Louis; Perreault, Sebastien; Davidson, Tom; Tseng, Chi-Hong; Fallah, Aria

2017-03-01

Medulloblastoma is the most common form of brain malignancy of childhood. The mainstay of epidemiological data regarding childhood medulloblastoma is derived from case series, hence population-based studies are warranted to improve the accuracy of survival estimates. To utilize a big-data approach to update survival estimates in a contemporary cohort of children with medulloblastoma. We performed a population-based retrospective observational cohort study utilizing the Surveillance, Epidemiology, and End Results Program database that captures all children, less than 20 years of age, between 1973 and 2012 in 18 geographical regions representing 28% of the US population. We included all participants with a presumed or histologically diagnosis of medulloblastoma. The main outcome of interest is survivors at 1, 5 and 10 years following diagnosis. A cohort of 1735 children with a median (interquartile range) age at diagnosis of 7 (4-11) years, with a diagnosis of medulloblastoma were identified. The incidence and prevalence of pediatric medulloblastoma has remained stable over the past 4 decades. There is a critical time point at 1990 when the overall survival has drastically improved. In the contemporary cohort (1990 onwards), the percentage of participants alive was 86, 70 and 63% at 1, 5 and 10 years, respectively. Multivariate Cox-Regression model demonstrated Radiation (HR 0.37; 95% CI 0.30-0.46, p < 0.001) and Surgery (HR 0.42; 95% CI 0.30-0.58, p < 0.001) independently predict survival. The probability of mortality from a neurological cause is <5% in patients who are alive 8 years following diagnosis. The SEER cohort analysis demonstrates significant improvements in pediatric medulloblastoma survival. In contrast to previous reports, the majority of patients survive in the modern era, and those alive 8 years following initial diagnosis are likely a long-term survivor. The importance of minimizing treatment-related toxicity is increasingly apparent given

Scissor-type knife significantly improves self-completion rate of colorectal endoscopic submucosal dissection: Single-center prospective randomized trial.

PubMed

Yamashina, Takeshi; Takeuchi, Yoji; Nagai, Kengo; Matsuura, Noriko; Ito, Takashi; Fujii, Mototsugu; Hanaoka, Noboru; Higashino, Koji; Uedo, Noriya; Ishihara, Ryu; Iishi, Hiroyasu

2017-05-01

Colorectal endoscopic submucosal dissection (C-ESD) is recognized as a difficult procedure. Recently, scissors-type knives were launched to reduce the difficulty of C-ESD. The aim of this study was to evaluate the efficacy and safety of the combined use of a scissors-type knife and a needle-type knife with a water-jet function (WJ needle-knife) for C-ESD compared with using the WJ needle-knife alone. This was a prospective randomized controlled trial in a referral center. Eighty-five patients with superficial colorectal neoplasms were enrolled and randomly assigned to undergo C-ESD using a WJ needle-knife alone (Flush group) or a scissor-type knife-supported WJ needle-knife (SB Jr group). Procedures were conducted by two supervised residents. Primary endpoint was self-completion rate by the residents. Self-completion rate was 67% in the SB Jr group, which was significantly higher than that in the Flush group (39%, P = 0.01). Even after exclusion of four patients in the SB Jr group in whom C-ESD was completed using the WJ needle-knife alone, the self-completion rate was significantly higher (63% vs 39%; P = 0.03). Median procedure time among the self-completion cases did not differ significantly between the two groups (59 vs 51 min; P = 0.14). No fatal adverse events were observed in either group. In this single-center phase II trial, scissor-type knife significantly improved residents' self-completion rate for C-ESD, with no increase in procedure time or adverse events. A multicenter trial would be warranted to confirm the validity of the present study. © 2016 Japan Gastroenterological Endoscopy Society.

Improved Sensor Fault Detection, Isolation, and Mitigation Using Multiple Observers Approach

PubMed Central

Wang, Zheng; Anand, D. M.; Moyne, J.; Tilbury, D. M.

2017-01-01

Traditional Fault Detection and Isolation (FDI) methods analyze a residual signal to detect and isolate sensor faults. The residual signal is the difference between the sensor measurements and the estimated outputs of the system based on an observer. The traditional residual-based FDI methods, however, have some limitations. First, they require that the observer has reached its steady state. In addition, residual-based methods may not detect some sensor faults, such as faults on critical sensors that result in an unobservable system. Furthermore, the system may be in jeopardy if actions required for mitigating the impact of the faulty sensors are not taken before the faulty sensors are identified. The contribution of this paper is to propose three new methods to address these limitations. Faults that occur during the observers' transient state can be detected by analyzing the convergence rate of the estimation error. Open-loop observers, which do not rely on sensor information, are used to detect faults on critical sensors. By switching among different observers, we can potentially mitigate the impact of the faulty sensor during the FDI process. These three methods are systematically integrated with a previously developed residual-based method to provide an improved FDI and mitigation capability framework. The overall approach is validated mathematically, and the effectiveness of the overall approach is demonstrated through simulation on a 5-state suspension system. PMID:28924303

Action observation training of community ambulation for improving walking ability of patients with post-stroke hemiparesis: a randomized controlled pilot trial.

PubMed

Park, Hyun-Ju; Oh, Duck-Won; Choi, Jong-Duk; Kim, Jong-Man; Kim, Suhn-Yeop; Cha, Yong-Jun; Jeon, Su-Jin

2017-08-01

To investigate the effects of action observation training involving community-based ambulation for improving walking ability after stroke. Randomized, controlled pilot study. Inpatient rehabilitation hospital. A total of 25 inpatients with post-stroke hemiparesis were randomly assigned to either the experimental group ( n = 12) or control group ( n = 13). Subjects of the experimental group watched video clips demonstrating four-staged ambulation training with a more complex environment factor for 30 minutes, three times a week for four weeks. Meanwhile, subjects of the control group watched video clips, which showed different landscape pictures. Walking function was evaluated before and after the four-week intervention using a 10-m walk test, community walk test, activities-specific balance confidence scale, and spatiotemporal gait measures. Changes in the values for the 10-m walk test (0.17 ±0.19 m/s vs. 0.05 ±0.08 m/s), community walk test (-151.42 ±123.82 seconds vs. 67.08 ±176.77 seconds), and activities-specific balance confidence (6.25 ±5.61 scores vs. 0.72 ±2.24 scores) and the spatiotemporal parameters (i.e. stride length (19.00 ±11.34 cm vs. 3.16 ±11.20 cm), single support (5.87 ±5.13% vs. 0.25 ±5.95%), and velocity (15.66 ±12.34 cm/s vs. 2.96 ±10.54 cm/s)) indicated a significant improvement in the experimental group compared with the control group. In the experimental group, walking function and ambulation confidence was significantly different between the pre- and post-intervention, whereas the control group showed a significant difference only in the 10-m walk test. Action observation training of community ambulation may be favorably used for improving walking function of patients with post-stroke hemiparesis.

Assimilation of Global Radar Backscatter and Radiometer Brightness Temperature Observations to Improve Soil Moisture and Land Evaporation Estimates

NASA Technical Reports Server (NTRS)

Lievens, H.; Martens, B.; Verhoest, N. E. C.; Hahn, S.; Reichle, R. H.; Miralles, D. G.

2017-01-01

Active radar backscatter (s?) observations from the Advanced Scatterometer (ASCAT) and passive radiometer brightness temperature (TB) observations from the Soil Moisture Ocean Salinity (SMOS) mission are assimilated either individually or jointly into the Global Land Evaporation Amsterdam Model (GLEAM) to improve its simulations of soil moisture and land evaporation. To enable s? and TB assimilation, GLEAM is coupled to the Water Cloud Model and the L-band Microwave Emission from the Biosphere (L-MEB) model. The innovations, i.e. differences between observations and simulations, are mapped onto the model soil moisture states through an Ensemble Kalman Filter. The validation of surface (0-10 cm) soil moisture simulations over the period 2010-2014 against in situ measurements from the International Soil Moisture Network (ISMN) shows that assimilating s? or TB alone improves the average correlation of seasonal anomalies (Ran) from 0.514 to 0.547 and 0.548, respectively. The joint assimilation further improves Ran to 0.559. Associated enhancements in daily evaporative flux simulations by GLEAM are validated based on measurements from 22 FLUXNET stations. Again, the singular assimilation improves Ran from 0.502 to 0.536 and 0.533, respectively for s? and TB, whereas the best performance is observed for the joint assimilation (Ran = 0.546). These results demonstrate the complementary value of assimilating radar backscatter observations together with brightness temperatures for improving estimates of hydrological variables, as their joint assimilation outperforms the assimilation of each observation type separately.

Significant improvement of the quality of bystander first aid using an expert system with a mobile multimedia device.

PubMed

Ertl, Lorenz; Christ, Frank

2007-08-01

Better quality bystander first-aid could improve outcome rates for emergency victims significantly. In this case-control study, we hypothesised that expert knowledge presented step-by-step to untrained helpers using a personal digital assistant (PDA), would improve the quality of bystanders basic life support. We confronted 101 lay-helpers with two standard emergency situations. (1) An unconscious trauma victim with severe bleeding. (2) Cardiopulmonary resuscitation (CPR). Performance was assessed using an Objective Structured Clinical Examination (OSCE). One group was supported by a PDA providing visual and audio instructions, whereas the control group acted only with their current knowledge. The expert system was programmed in HTML-code and displayed on the PDA's Internet browser. The maximum score obtainable was 24 points corresponding to optimal treatment. The control group without the PDA reached 14.8+/-3.5 (mean value+/-standard deviation), whereas the PDA supported group scored significantly higher (21.9+/-2.7, p<0.01). The difference in performance was measurable in all criteria tested and particularly notable in the items: placing in recovery position, airway management and quality of CPR. The PDA based expert system increased the performance of untrained helpers supplying emergency care significantly. Since Internet compatible mobile devices have become widely available, a significant quality improvement in bystander first-aid seems possible.

Improving significantly the failure strain and work hardening response of LPSO-strengthened Mg-Y-Zn-Al alloy via hot extrusion speed control

NASA Astrophysics Data System (ADS)

Tan, Xinghe; Chee, Winston; Chan, Jimmy; Kwok, Richard; Gupta, Manoj

2017-07-01

The effect of hot extrusion speed on the microstructure and mechanical properties of MgY1.06Zn0.76Al0.42 (at%) alloy strengthened by the novel long-period stacking ordered (LPSO) phase was systematically investigated. Increase in the speed of extrusion accelerated dynamic recrystallization of α-Mg via particle-stimulated nucleation and grain growth in the alloy. The intensive recrystallization and grain growth events weakened the conventional basal texture and Hall-Petch strengthening in the alloy which led to significant improvement in its failure strain from 4.9% to 19.6%. The critical strengthening contribution from LPSO phase known for attributing high strength to the alloy was observed to be greatly undermined by the parallel competition from texture weakening and the adverse Hall-Petch effect when the alloy was extruded at higher speed. Absence of work hardening interestingly observed in the alloy extruded at lower speed was discussed in terms of its ultra-fine grained microstructure which promoted the condition of steady-state defect density in the alloy; where dislocation annihilation balances out the generation of new dislocations during plastic deformation. One approach to improve work hardening response of the alloy to prevent unstable deformation and abrupt failure in service is to increase the grain diameter in the alloy by judiciously increasing the extrusion speed.

Significant improvement in the interface thermal conductivity of graphene-nanoplatelets/silicone composite

NASA Astrophysics Data System (ADS)

Lv, Jian; Cai, Xiaoming; Ye, Qianxu; Zhang, Hui; Ruan, Zilin; Cai, Jinming

2018-05-01

Heat conducting silica gel sheets with graphene nanoplatelets (GNPs) filler prepared by high pressure homogenization were fabricated. The dispersed GNPs filler in silica gel significantly affects the thermal conductivity of GNPs silica gel sheets (GNPs-SGS). The thermal conductivity of GNPs-SGS with 5 wt% GNPs reaches 0.43 W(m · k)‑1 which increased by 110% and 50% comparing to the pure silica gel sheets (Pure-SGS) and graphite silica gel sheets (GP-SGS) with the same mass fraction. The efficient of heat conduction of heat-sink device which made of GNPs-SGS with 5 wt% is higher than the one which made of Pure-SGS. Besides, The temperature of the thermal plate is 22 °C lower when using 5 wt% GNPs-SGS compared to the bare one measured by thermal management simulator (TMS), proving its good heat radiation ability. FE-SEM was used to observe the fillers and the section of gel sheets, it can be clearly observed the layered and the uniform distribution of GNPs in the matrix. The facile process of high pressure homogenization to exfoliate GNPs is a feasible program for industrial production.

[Clinical and pathological significance of carotid siphon calcification observed on bone condition of brain CT].

PubMed

Matsumoto, Hideyuki; Hamaguchi, Hirotoshi; Nakayama, Takahiro; Oda, Tetsuya; Ikagawa, Takashi; Imafuku, Ichiro

2008-02-01

On plain brain computed tomography (CT), it is difficult to evaluate stenosis of internal carotid artery (ICA) because ICA is surrounded by structures, even though we can observe calcification of carotid siphon in some patients by using bone condition. However the pathologic significance has not been well known. We studied the pathologic significance of carotid siphon calcification observed on bone condition of brain CT. A total of 112 patients who were diagnosed or suspected as cerebrovascular diseases were registered. We classified the calcification into four levels (none, mild, moderate, severe) based on the degree of calcification. Then we compared it with the degree of stenosis of carotid siphon seen on brain magnetic resonance angiography (MRA) and with max intima-medial thickness (IMT) from common carotid artery (CCA) to ICA on carotid ultrasonography. The mean +/- standard deviation of max IMT to none, mild, moderate and severe in the degree of calcification were 1.03 +/- 0.64 (0.4-2.8), 1.65 +/- 0.83 (0.5-4.1), 2.03 +/- 0.83 (0.8-4.1) and 2.81 +/- 1.15 (0.7-6.5) mm, respectively. The calcification on brain CT significantly correlated with the degree of stenosis on brain MRA and with max IMT on carotid ultrasonography. The calcification of carotid siphon on bone condition of brain CT correlated with stenosis of the same portion and atherosclerosis of CCA bifurcation. Recently, on DICOM viewer, clinicians can convert plain condition into bone condition on brain CT due to popularization of PACS. We should pay attention to calcification of carotid siphon in patients with ischemic cerebrovascular diseases because we can estimate the atherosclerosis of both carotid siphon and CCA bifurcation easily and immediately.

The Use of Classroom Walk-Through Observations as a Strategy to Improve Teaching and Learning: An Administrative Perspective

ERIC Educational Resources Information Center

Weller, Mark J.

2010-01-01

The purpose of this study was to identify the possible use of structured classroom walk-through observations as a strategy to improve teaching and learning. A wide variety of programs and initiatives have recently been implemented across the country to improve student achievement. One such initiative is classroom walk-through observations.…

Pasireotide treatment significantly improves clinical signs and symptoms in patients with Cushing's disease: results from a Phase III study.

PubMed

Pivonello, Rosario; Petersenn, Stephan; Newell-Price, John; Findling, James W; Gu, Feng; Maldonado, Mario; Trovato, Andrew; Hughes, Gareth; Salgado, Luiz R; Lacroix, André; Schopohl, Jochen; Biller, Beverly M K

2014-09-01

Signs and symptoms of Cushing's disease are associated with high burden of illness. In this analysis, we evaluated the effect of pasireotide treatment on signs and symptoms in patients with Cushing's disease. Phase III study with double-blind randomization of two pasireotide doses. Patients (n = 162) with persistent/recurrent or de novo Cushing's disease and urinary free cortisol (UFC) levels ≥1·5× upper limit of normal (ULN) were randomized to receive subcutaneous pasireotide (600/900 μg bid). At month 3, patients with UFC ≤2 × ULN and not exceeding the baseline value continued their randomized dose; all others received 300 μg bid uptitration. At month 6, patients could enter an open-label phase until month 12 with a maximal dose of 1200 μg bid. Changes in signs and symptoms of hypercortisolism over 12 months' treatment in patients still enroled in the study and with evaluable measurements were assessed in relation to degree of UFC control. Reductions in blood pressure were observed even without full UFC control and were greatest in patients who did not receive antihypertensive medications during the study. Significant reductions in total cholesterol and low-density lipoprotein (LDL)-cholesterol were observed in patients who achieved UFC control. Reductions in BMI, weight and waist circumference occurred during the study even without full UFC control. Adverse effects were typical of somatostatin analogues except for hyperglycaemia-related events, which were experienced by 72·8% of patients. In the largest Phase III study of medical therapy in Cushing's disease, significant improvements in signs and symptoms were seen during 12 months of pasireotide treatment, as UFC levels decreased. © 2014 John Wiley & Sons Ltd.

Improving visual observation skills through the arts to aid radiographic interpretation in veterinary practice: A pilot study.

PubMed

Beck, Cathy; Gaunt, Heather; Chiavaroli, Neville

2017-09-01

Radiographic interpretation is a perceptual and cognitive skill. Recently core veterinary radiology textbooks have focused on the cognitive (i.e., the clinical aspects of radiographic interpretation) rather than the features of visual observation that improve identification of abnormalities. As a result, the skill of visual observation is underemphasized and thus often underdeveloped by trainees. The study of the arts in medical education has been used to train and improve visual observation and empathy. The use of the arts to improve visual observation skills in Veterinary Science has not been previously described. Objectives of this pilot study were to adapt the existing Visual Arts in Health Education Program for medical and dental students at the University of Melbourne, Australia to third year Doctor of Veterinary Medicine students and evaluate their perceptions regarding the program's effects on visual observation skills and confidence with respect to radiographic interpretation. This adaptation took the form of a single seminar given to third year Doctor of Veterinary Medicine students. Following the seminar, students reported an improved approach to radiographic interpretation and felt they had gained skills which would assist them throughout their career. In the year following the seminar, written reports of the students who attended the seminar were compared with reports from a matched cohort of students who did not attend the seminar. This demonstrated increased identification of abnormalities and greater description of the abnormalities identified. Findings indicated that explicit training in visual observation may be a valuable adjunct to the radiology training of Doctor of Veterinary Medicine students. © 2017 American College of Veterinary Radiology.

Using Deep Learning for Targeted Data Selection, Improving Satellite Observation Utilization for Model Initialization

NASA Astrophysics Data System (ADS)

Lee, Y. J.; Bonfanti, C. E.; Trailovic, L.; Etherton, B.; Govett, M.; Stewart, J.

2017-12-01

At present, a fraction of all satellite observations are ultimately used for model assimilation. The satellite data assimilation process is computationally expensive and data are often reduced in resolution to allow timely incorporation into the forecast. This problem is only exacerbated by the recent launch of Geostationary Operational Environmental Satellite (GOES)-16 satellite and future satellites providing several order of magnitude increase in data volume. At the NOAA Earth System Research Laboratory (ESRL) we are researching the use of machine learning the improve the initial selection of satellite data to be used in the model assimilation process. In particular, we are investigating the use of deep learning. Deep learning is being applied to many image processing and computer vision problems with great success. Through our research, we are using convolutional neural network to find and mark regions of interest (ROI) to lead to intelligent extraction of observations from satellite observation systems. These targeted observations will be used to improve the quality of data selected for model assimilation and ultimately improve the impact of satellite data on weather forecasts. Our preliminary efforts to identify the ROI's are focused in two areas: applying and comparing state-of-art convolutional neural network models using the analysis data from the National Center for Environmental Prediction (NCEP) Global Forecast System (GFS) weather model, and using these results as a starting point to optimize convolution neural network model for pattern recognition on the higher resolution water vapor data from GOES-WEST and other satellite. This presentation will provide an introduction to our convolutional neural network model to identify and process these ROI's, along with the challenges of data preparation, training the model, and parameter optimization.

Spontaneous Resolution of Long-Standing Macular Detachment due to Optic Disc Pit with Significant Visual Improvement.

PubMed

Parikakis, Efstratios A; Chatziralli, Irini P; Peponis, Vasileios G; Karagiannis, Dimitrios; Stratos, Aimilianos; Tsiotra, Vasileia A; Mitropoulos, Panagiotis G

2014-01-01

To report a case of spontaneous resolution of a long-standing serous macular detachment associated with an optic disc pit, leading to significant visual improvement. A 63-year-old female presented with a 6-month history of blurred vision and micropsia in her left eye. Her best-corrected visual acuity was 6/24 in the left eye, and fundoscopy revealed serous macular detachment associated with optic disc pit, which was confirmed by optical coherence tomography (OCT). The patient was offered vitrectomy as a treatment alternative, but she preferred to be reviewed conservatively. Three years after initial presentation, neither macular detachment nor subretinal fluid was evident in OCT, while the inner segment/outer segment (IS/OS) junction line was intact. Her visual acuity was improved from 6/24 to 6/12 in her left eye, remaining stable at the 6-month follow-up after resolution. We present a case of spontaneous resolution of a long-standing macular detachment associated with an optic disc pit with significant visual improvement, postulating that the integrity of the IS/OS junction line may be a prognostic factor for final visual acuity and suggesting OCT as an indicator of visual prognosis and the probable necessity of a surgical management.

Improving the quality of preclinical research echocardiography: Observations, training and guidelines for measurement.

PubMed

Donner, Daniel G; Kiriazis, Helen; Du, Xiao-Jun; Marwick, Thomas H; McMullen, Julie R

2018-04-20

Informal training in preclinical research may be a contributor to the poor reproducibility of preclinical cardiology research and low rates of translation into clinical research and practice. Mouse echocardiography is a widely used technique to assess cardiac structure and function in drug intervention studies using disease models. The inter-observer variability (IOV) of clinical echocardiographic measurements has been shown to improve with formalized training, but preclinical echocardiography lacks similarly critical standardization of training. The aims of this investigation were to assess the IOV of echocardiographic measurements from studies in mice, and address any technical impediments to reproducibility by implementing standardized guidelines through formalized training. In this prospective, single-site, observational cohort study, 13 scientists performing preclinical echocardiographic image analysis were assessed for measurement of short-axis M-mode-derived dimensions and calculated left ventricular mass (LVMass). Ten M-mode images of mouse hearts acquired and analyzed by an expert researcher with a spectrum of LVMass were selected for assessment, and validated by autopsy weight. Following the initial observation, a structured formal training program was introduced, and accuracy and reproducibility were re-evaluated. Mean absolute percentage error (MAPE) for Expert-calculated LVMass was 6{plus minus}4% compared to autopsy LVMass, and 25{plus minus}21% for participants before training. Standardized formal training improved participant MAPE by approximately 30% relative to expert-calculated LVMass (p<0.001). Participants initially categorized with high-range error (25-45%) improved to low-moderate error ranges (<15-25%). This report reveals an example of technical skill training insufficiency likely endemic to preclinical research and provides validated guidelines for echocardiographic measurement for adaptation to formalized in-training programs.

An initiative to improve the management of clinically significant test results in a large health care network.

PubMed

Roy, Christopher L; Rothschild, Jeffrey M; Dighe, Anand S; Schiff, Gordon D; Graydon-Baker, Erin; Lenoci-Edwards, Jennifer; Dwyer, Cheryl; Khorasani, Ramin; Gandhi, Tejal K

2013-11-01

The failure of providers to communicate and follow up clinically significant test results (CSTR) is an important threat to patient safety. The Massachusetts Coalition for the Prevention of Medical Errors has endorsed the creation of systems to ensure that results can be received and acknowledged. In 2008 a task force was convened that represented clinicians, laboratories, radiology, patient safety, risk management, and information systems in a large health care network with the goals of providing recommendations and a road map for improvement in the management of CSTR and of implementing this improvement plan during the sub-force sequent five years. In drafting its charter, the task broadened the scope from "critical" results to "clinically significant" ones; clinically significant was defined as any result that requires further clinical action to avoid morbidity or mortality, regardless of the urgency of that action. The task force recommended four key areas for improvement--(1) standardization of policies and definitions, (2) robust identification of the patient's care team, (3) enhanced results management/tracking systems, and (4) centralized quality reporting and metrics. The task force faced many challenges in implementing these recommendations, including disagreements on definitions of CSTR and on who should have responsibility for CSTR, changes to established work flows, limitations of resources and of existing information systems, and definition of metrics. This large-scale effort to improve the communication and follow-up of CSTR in a health care network continues with ongoing work to address implementation challenges, refine policies, prepare for a new clinical information system platform, and identify new ways to measure the extent of this important safety problem.

Improving Ambiguity Resolution for Medium Baselines Using Combined GPS and BDS Dual/Triple-Frequency Observations

PubMed Central

Gao, Wang; Gao, Chengfa; Pan, Shuguo; Wang, Denghui; Deng, Jiadong

2015-01-01

The regional constellation of the BeiDou navigation satellite system (BDS) has been providing continuous positioning, navigation and timing services since 27 December 2012, covering China and the surrounding area. Real-time kinematic (RTK) positioning with combined BDS and GPS observations is feasible. Besides, all satellites of BDS can transmit triple-frequency signals. Using the advantages of multi-pseudorange and carrier observations from multi-systems and multi-frequencies is expected to be of much benefit for ambiguity resolution (AR). We propose an integrated AR strategy for medium baselines by using the combined GPS and BDS dual/triple-frequency observations. In the method, firstly the extra-wide-lane (EWL) ambiguities of triple-frequency system, i.e., BDS, are determined first. Then the dual-frequency WL ambiguities of BDS and GPS were resolved with the geometry-based model by using the BDS ambiguity-fixed EWL observations. After that, basic (i.e., L1/L2 or B1/B2) ambiguities of BDS and GPS are estimated together with the so-called ionosphere-constrained model, where the ambiguity-fixed WL observations are added to enhance the model strength. During both of the WL and basic AR, a partial ambiguity fixing (PAF) strategy is adopted to weaken the negative influence of new-rising or low-elevation satellites. Experiments were conducted and presented, in which the GPS/BDS dual/triple-frequency data were collected in Nanjing and Zhengzhou of China, with the baseline distance varying from about 28.6 to 51.9 km. The results indicate that, compared to the single triple-frequency BDS system, the combined system can significantly enhance the AR model strength, and thus improve AR performance for medium baselines with a 75.7% reduction of initialization time on average. Besides, more accurate and stable positioning results can also be derived by using the combined GPS/BDS system. PMID:26528977

Improving Ambiguity Resolution for Medium Baselines Using Combined GPS and BDS Dual/Triple-Frequency Observations.

PubMed

Gao, Wang; Gao, Chengfa; Pan, Shuguo; Wang, Denghui; Deng, Jiadong

2015-10-30

The regional constellation of the BeiDou navigation satellite system (BDS) has been providing continuous positioning, navigation and timing services since 27 December 2012, covering China and the surrounding area. Real-time kinematic (RTK) positioning with combined BDS and GPS observations is feasible. Besides, all satellites of BDS can transmit triple-frequency signals. Using the advantages of multi-pseudorange and carrier observations from multi-systems and multi-frequencies is expected to be of much benefit for ambiguity resolution (AR). We propose an integrated AR strategy for medium baselines by using the combined GPS and BDS dual/triple-frequency observations. In the method, firstly the extra-wide-lane (EWL) ambiguities of triple-frequency system, i.e., BDS, are determined first. Then the dual-frequency WL ambiguities of BDS and GPS were resolved with the geometry-based model by using the BDS ambiguity-fixed EWL observations. After that, basic (i.e., L1/L2 or B1/B2) ambiguities of BDS and GPS are estimated together with the so-called ionosphere-constrained model, where the ambiguity-fixed WL observations are added to enhance the model strength. During both of the WL and basic AR, a partial ambiguity fixing (PAF) strategy is adopted to weaken the negative influence of new-rising or low-elevation satellites. Experiments were conducted and presented, in which the GPS/BDS dual/triple-frequency data were collected in Nanjing and Zhengzhou of China, with the baseline distance varying from about 28.6 to 51.9 km. The results indicate that, compared to the single triple-frequency BDS system, the combined system can significantly enhance the AR model strength, and thus improve AR performance for medium baselines with a 75.7% reduction of initialization time on average. Besides, more accurate and stable positioning results can also be derived by using the combined GPS/BDS system.

Age is a significant predictor of early and late improvement in semen parameters after microsurgical varicocele repair.

PubMed

Kimura, M; Nagao, K; Tai, T; Kobayashi, H; Nakajima, K

2017-04-01

Accumulating evidence indicates that varicocele repair improves sperm quality. However, longitudinal changes in sperm parameters and predictors of improved semen characteristics after surgery have not been fully investigated. We retrospectively reviewed data from 100 men who underwent microsurgical subinguinal varicocele repair at a single centre. Follow-up semen examinations were carried out at 3, 6 and 12 months post-operatively. Logistic regression was used to identify predictors of early (3 months) and late (≥6 months) improvement in semen parameters after varicocele repair. At 3 months post-operatively, 76.1% of the patients had improved total motile sperm counts, which continued to improve significantly up to 12 months post-operatively (p = .016). When comparing changes in semen parameters between younger (<37 years) and older (≥37 years) men, post-operative improvements in sperm concentration and motility were greater among younger men. Multivariate analysis showed that younger age was associated with early (p = .043) and late (p = .010) post-operative improvement in total motile sperm count. Our findings indicate that early varicocele repair improved semen parameters after surgery. © 2016 Blackwell Verlag GmbH.

Improving Arctic Sea Ice Observations and Data Access to Support Advances in Sea Ice Forecasting

NASA Astrophysics Data System (ADS)

Farrell, S. L.

2017-12-01

The economic and strategic importance of the Arctic region is becoming apparent. One of the most striking and widely publicized changes underway is the declining sea ice cover. Since sea ice is a key component of the climate system, its ongoing loss has serious, and wide-ranging, socio-economic implications. Increasing year-to-year variability in the geographic location, concentration, and thickness of the Arctic ice cover will pose both challenges and opportunities. The sea ice research community must be engaged in sustained Arctic Observing Network (AON) initiatives so as to deliver fit-for-purpose remote sensing data products to a variety of stakeholders including Arctic communities, the weather forecasting and climate modeling communities, industry, local, regional and national governments, and policy makers. An example of engagement is the work currently underway to improve research collaborations between scientists engaged in obtaining and assessing sea ice observational data and those conducting numerical modeling studies and forecasting ice conditions. As part of the US AON, in collaboration with the Interagency Arctic Research Policy Committee (IARPC), we are developing a strategic framework within which observers and modelers can work towards the common goal of improved sea ice forecasting. Here, we focus on sea ice thickness, a key varaible of the Arctic ice cover. We describe multi-sensor, and blended, sea ice thickness data products under development that can be leveraged to improve model initialization and validation, as well as support data assimilation exercises. We will also present the new PolarWatch initiative (polarwatch.noaa.gov) and discuss efforts to advance access to remote sensing satellite observations and improve communication with Arctic stakeholders, so as to deliver data products that best address societal needs.

Improving the Interoperability and Usability of NASA Earth Observation Data

NASA Astrophysics Data System (ADS)

Walter, J.; Berrick, S. W.; Murphy, K. J.; Mitchell, A. E.; Tilmes, C.

2014-12-01

NASA's Earth Science Data and Information System Project (ESDIS) is charged with managing, maintaining, and evolving NASA's Earth Observing System Data and Information System (EOSDIS) and is responsible for processing, archiving, and distributing NASA Earth Science data. The system supports a multitude of missions and serves diverse science research and other user communities. While NASA has made, and continues to make, great strides in the discoverability and accessibility of its earth observation data holdings, issues associated with data interoperability and usability still present significant challenges to realizing the full scientific and societal benefits of these data. This concern has been articulated by multiple government agencies, both U.S. and international, as well as other non-governmental organizations around the world. Among these is the White House Office of Science and Technology Policy who, in response, has launched the Big Earth Data Initiative and the Climate Data Initiative to address these concerns for U.S. government agencies. This presentation will describe NASA's approach for addressing data interoperability and usability issues with our earth observation data.

Occipital nerve stimulation improves the quality of life in medically-intractable chronic cluster headache: Results of an observational prospective study.

PubMed

Fontaine, Denys; Blond, Serge; Lucas, Christian; Regis, Jean; Donnet, Anne; Derrey, Stéphane; Guegan-Massardier, Evelyne; Jarraya, Bechir; Dang-Vu, Bich; Bourdain, Frederic; Valade, Dominique; Roos, Caroline; Creach, Christèle; Chabardes, Stéphan; Giraud, Pierric; Voirin, Jimmy; Bloch, Jocelyne; Rocca, Alda; Colnat-Coulbois, Sophie; Caire, Francois; Roger, Coralie; Romettino, Sylvie; Lanteri-Minet, Michel

2017-10-01

Background Occipital nerve stimulation (ONS) has been proposed to treat chronic medically-intractable cluster headache (iCCH) in small series of cases without evaluation of its functional and emotional impacts. Methods We report the multidimensional outcome of a large observational study of iCCH patients, treated by ONS within a nationwide multidisciplinary network ( https://clinicaltrials.gov NCT01842763), with a one-year follow-up. Prospective evaluation was performed before surgery, then three and 12 months after. Results One year after ONS, the attack frequency per week was decreased >30% in 64% and >50% in 59% of the 44 patients. Mean (Standard Deviation) weekly attack frequency decreased from 21.5 (16.3) to 10.7 (13.8) ( p = 0.0002). About 70% of the patients responded to ONS, 47.8% being excellent responders. Prophylactic treatments could be decreased in 40% of patients. Functional (HIT-6 and MIDAS scales) and emotional (HAD scale) impacts were significantly improved, as well as the health-related quality of life (EQ-5D). The mean (SD) EQ-5D visual analogic scale score increased from 35.2 (23.6) to 51.9 (25.7) ( p = 0.0037). Surgical minor complications were observed in 33% of the patients. Conclusion ONS significantly reduced the attack frequency per week, as well as the functional and emotional headache impacts in iCCH patients, and dramatically improved the health-related quality of life of responders.

Developing Vocabularies to Improve Understanding and Use of NOAA Observing Systems

NASA Astrophysics Data System (ADS)

Austin, M.

2014-12-01

The NOAA Observing System Integrated Analysis project (NOSIA II), is an attempt to capture and tell the story of how valuable observing systems are in producing products and services that are required to fulfill the NOAA's diverse mission. NOAA's goals and mission areas cover a broad range of environmental data; a complexity exists in terms and vocabulary as applied to the creation of observing system derived products. The NOSIA data collection focused first on decomposing NOAA's goals in the creation and acceptance of Mission Service Areas (MSAs) by NOAA senior leadership. Products and services that supported the MSAs were then identified through the process of interviewing product producers across NOAA organization. Product Data inputs including models, databases and observing system were also identified. The NOSIA model contains over 20,000 nodes each representing levels in a network connecting products, datasources, users and desired outcomes. An immediate need became apparent that the complexity and variety of the data collected required data management to mature the quality and the content of the NOSIA model. The NOSIA Analysis Database (ADB) was developed initially to improve consistency of terms and data types to allow for the linkage of observing systems, products and NOAA's Goals and mission. The ADB also allowed for the prototyping of reports and product generation in an easily accessible and comprehensive format for the first time. Web based visualization of relationships between products, datasources, users, producers were generated to make the information easily understood This includes developing ontologies/vocabularies that are used for the development of users type specific products for NOAA leadership, Observing System Portfolio mangers and the users of NOAA data.

Improved forecasts of winter weather extremes over midlatitudes with extra Arctic observations

NASA Astrophysics Data System (ADS)

Sato, Kazutoshi; Inoue, Jun; Yamazaki, Akira; Kim, Joo-Hong; Maturilli, Marion; Dethloff, Klaus; Hudson, Stephen R.; Granskog, Mats A.

2017-02-01

Recent cold winter extremes over Eurasia and North America have been considered to be a consequence of a warming Arctic. More accurate weather forecasts are required to reduce human and socioeconomic damages associated with severe winters. However, the sparse observing network over the Arctic brings errors in initializing a weather prediction model, which might impact accuracy of prediction results at midlatitudes. Here we show that additional Arctic radiosonde observations from the Norwegian young sea ICE expedition (N-ICE2015) drifting ice camps and existing land stations during winter improved forecast skill and reduced uncertainties of weather extremes at midlatitudes of the Northern Hemisphere. For two winter storms over East Asia and North America in February 2015, ensemble forecast experiments were performed with initial conditions taken from an ensemble atmospheric reanalysis in which the observation data were assimilated. The observations reduced errors in initial conditions in the upper troposphere over the Arctic region, yielding more precise prediction of the locations and strengths of upper troughs and surface synoptic disturbances. Errors and uncertainties of predicted upper troughs at midlatitudes would be brought with upper level high potential vorticity (PV) intruding southward from the observed Arctic region. This is because the PV contained a "signal" of the additional Arctic observations as it moved along an isentropic surface. This suggests that a coordinated sustainable Arctic observing network would be effective not only for regional weather services but also for reducing weather risks in locations distant from the Arctic.

Improved inter-observer agreement of an expert review panel in an oncology treatment trial--Insights from a structured interventional process.

PubMed

Nestle, Ursula; Rischke, Hans Christian; Eschmann, Susanne Martina; Holl, Gabriele; Tosch, Marco; Miederer, Matthias; Plotkin, Michail; Essler, Markus; Puskas, Cornelia; Schimek-Jasch, Tanja; Duncker-Rohr, Viola; Rühl, Friederike; Leifert, Anja; Mix, Michael; Grosu, Anca-Ligia; König, Jochem; Vach, Werner

2015-11-01

Oncologic imaging is a key for successful cancer treatment. While the quality assurance (QA) of image acquisition protocols has already been focussed, QA of reading and reporting offers still room for improvement. The latter was addressed in the context of a prospective multicentre trial on fluoro-deoxyglucose (FDG)-positron-emission tomography (PET)/CT-based chemoradiotherapy for locally advanced non-small cell lung cancer (NSCLC). An expert panel was prospectively installed performing blinded reviews of mediastinal NSCLC involvement in FDG-PET/CT. Due to a high initial reporting inter-observer disagreement, the independent data monitoring committee (IDMC) triggered an interventional harmonisation process, which overall involved 11 experts uttering 6855 blinded diagnostic statements. After assessing the baseline inter-observer agreement (IOA) of a blinded re-review (phase 1), a discussion process led to improved reading criteria (phase 2). Those underwent a validation study (phase 3) and were then implemented into the study routine. After 2 months (phase 4) and 1 year (phase 5), the IOA was reassessed. The initial overall IOA was moderate (kappa 0.52 CT; 0.53 PET). After improvement of reading criteria, the kappa values improved substantially (kappa 0.61 CT; 0.66 PET), which was retained until the late reassessment (kappa 0.71 CT; 0.67 PET). Subjective uncertainty was highly predictive for low IOA. The IOA of an expert panel was significantly improved by a structured interventional harmonisation process which could be a model for future clinical trials. Furthermore, the low IOA in reporting nodal involvement in NSCLC may bear consequences for individual patient care. Copyright © 2015 Elsevier Ltd. All rights reserved.

Peer Observation: A Key Factor to Improve Iranian EFL Teachers' Professional Development

ERIC Educational Resources Information Center

Motallebzadeh, Khalil; Hosseinnia, Mansooreh; Domskey, Javad G. H.

2017-01-01

This study reports on the perspectives of a group of Iranian EFL teachers about peer observation effects. The aim was to investigate if peer observation as a reflective tool could significantly affect EFL teachers' professional development. It has been done based on a mixed method approach. The participants have stated their viewpoints on the…

Intelligent Photovoltaic Systems by Combining the Improved Perturbation Method of Observation and Sun Location Tracking.

PubMed

Wang, Yajie; Shi, Yunbo; Yu, Xiaoyu; Liu, Yongjie

2016-01-01

Currently, tracking in photovoltaic (PV) systems suffers from some problems such as high energy consumption, poor anti-interference performance, and large tracking errors. This paper presents a solar PV tracking system on the basis of an improved perturbation and observation method, which maximizes photoelectric conversion efficiency. According to the projection principle, we design a sensor module with a light-intensity-detection module for environmental light-intensity measurement. The effect of environmental factors on the system operation is reduced, and intelligent identification of the weather is realized. This system adopts the discrete-type tracking method to reduce power consumption. A mechanical structure with a level-pitch double-degree-of-freedom is designed, and attitude correction is performed by closed-loop control. A worm-and-gear mechanism is added, and the reliability, stability, and precision of the system are improved. Finally, the perturbation and observation method designed and improved by this study was tested by simulated experiments. The experiments verified that the photoelectric sensor resolution can reach 0.344°, the tracking error is less than 2.5°, the largest improvement in the charge efficiency can reach 44.5%, and the system steadily and reliably works.

Intelligent Photovoltaic Systems by Combining the Improved Perturbation Method of Observation and Sun Location Tracking

PubMed Central

Wang, Yajie; Shi, Yunbo; Yu, Xiaoyu; Liu, Yongjie

2016-01-01

Currently, tracking in photovoltaic (PV) systems suffers from some problems such as high energy consumption, poor anti-interference performance, and large tracking errors. This paper presents a solar PV tracking system on the basis of an improved perturbation and observation method, which maximizes photoelectric conversion efficiency. According to the projection principle, we design a sensor module with a light-intensity-detection module for environmental light-intensity measurement. The effect of environmental factors on the system operation is reduced, and intelligent identification of the weather is realized. This system adopts the discrete-type tracking method to reduce power consumption. A mechanical structure with a level-pitch double-degree-of-freedom is designed, and attitude correction is performed by closed-loop control. A worm-and-gear mechanism is added, and the reliability, stability, and precision of the system are improved. Finally, the perturbation and observation method designed and improved by this study was tested by simulated experiments. The experiments verified that the photoelectric sensor resolution can reach 0.344°, the tracking error is less than 2.5°, the largest improvement in the charge efficiency can reach 44.5%, and the system steadily and reliably works. PMID:27327657

Improvement of Operational Streamflow Prediction with MODIS-derived Fractional Snow Covered Area Observations

NASA Astrophysics Data System (ADS)

Bender, S.; Burgess, A.; Goodale, C. E.; Mattmann, C. A.; Miller, W. P.; Painter, T. H.; Rittger, K. E.; Stokes, M.; Werner, K.

2013-12-01

Water managers in the western United States depend heavily on the timing and magnitude of snowmelt-driven runoff for municipal supply, irrigation, maintenance of environmental flows, and power generation. The Colorado Basin River Forecast Center (CBRFC) of the National Weather Service issues operational forecasts of snowmelt-driven streamflow for watersheds within the Colorado River Basin (CRB) and eastern Great Basin (EGB), across a wide variety of scales. Therefore, the CBRFC and its stakeholders consider snowpack observations to be highly valuable. Observations of fractional snow covered area (fSCA) from satellite-borne instrumentation can better inform both forecasters and water users with respect to subsequent snowmelt runoff, particularly when combined with observations from ground-based station networks and/or airborne platforms. As part of a multi-year collaborative effort, CBRFC has partnered with the Jet Propulsion Laboratory (JPL) under funding from NASA to incorporate observations of fSCA from NASA's Moderate Resolution Imaging Spectroradiometer (MODIS) into the operational CBRFC hydrologic forecasting and modeling process. In the first year of the collaboration, CBRFC and NASA/JPL integrated snow products into the forecasting and decision making processes of the CBRFC and showed preliminary improvement in operational streamflow forecasts. In late 2012, CBRFC and NASA/JPL began retrospective analysis of relationships between the MODIS Snow Covered Area and Grain size (MODSCAG) fSCA and streamflow patterns for several watersheds within the CRB and the EGB. During the 2013 snowmelt runoff season, CBRFC forecasters used MODIS-derived fSCA semi-quantitatively as a binary indicator of the presence or lack of snow. Indication of the presence or lack of snow by MODIS assisted CBRFC forecasters in determining the cause of divergence between modeled and recently observed streamflow. Several examples of improved forecasts from across the CRB and EGB, informed by

Non-physical practice improves task performance in an unstable, perturbed environment: motor imagery and observational balance training

PubMed Central

Taube, Wolfgang; Lorch, Michael; Zeiter, Sibylle; Keller, Martin

2014-01-01

For consciously performed motor tasks executed in a defined and constant way, both motor imagery (MI) and action observation (AO) have been shown to promote motor learning. It is not known whether these forms of non-physical training also improve motor actions when these actions have to be variably applied in an unstable and unpredictable environment. The present study therefore investigated the influence of MI balance training (MI_BT) and a balance training combining AO and MI (AO+MI_BT) on postural control of undisturbed and disturbed upright stance on unstable ground. As spinal reflex excitability after classical (i.e., physical) balance training (BT) is generally decreased, we tested whether non-physical BT also has an impact on spinal reflex circuits. Thirty-six participants were randomly allocated into an MI_BT group, in which participants imagined postural exercises, an AO+MI_BT group, in which participants observed videos of other people performing balance exercises and imagined being the person in the video, and a non-active control group (CON). Before and after 4 weeks of non-physical training, balance performance was assessed on a free-moving platform during stance without perturbation and during perturbed stance. Soleus H-reflexes were recorded during stable and unstable stance. The post-measurement revealed significantly decreased postural sway during undisturbed and disturbed stance after both MI_BT and AO+MI_BT. Spinal reflex excitability remained unchanged. This is the first study showing that non-physical training (MI_BT and AO+MI_BT) not only promotes motor learning of “rigid” postural tasks but also improves performance of highly variable and unpredictable balance actions. These findings may be relevant to improve postural control and thus reduce the risk of falls in temporarily immobilized patients. PMID:25538598

Improvements to the CERES Cloud Detection Algorithm using Himawari 8 Data and Validation using CALIPSO and CATS Lidar Observations

NASA Astrophysics Data System (ADS)

Trepte, Q.; Minnis, P.; Palikonda, R.; Yost, C. R.; Rodier, S. D.; Trepte, C. R.; McGill, M. J.

2016-12-01

Geostationary satellites provide continuous cloud and meteorological observations important for weather forecasting and for understanding climate processes. The Himawari-8 satellite represents a new generation of measurement capabilities with significantly improved resolution and enhanced spectral information. The satellite was launched in October 2014 by the Japanese Meteorological Agency and is centered at 140° E to provide coverage over eastern Asia and the western Pacific region. A cloud detection algorithm was developed as part of the CERES Cloud Mask algorithm using the Advanced Himawari Imager (AHI), a 16 channel multi-spectral imager. The algorithm was originally designed for use with Meteosat Second Generation (MSG) data and has been adapted for Himawari-8 AHI measurements. This paper will describe the improvements in the Himawari cloud mask including daytime ocean low cloud and aerosol discrimination, nighttime thin cirrus detection, and Australian desert and coastal cloud detection. The statistics from matched CERES Himawari cloud mask results with CALIPSO lidar data and with new observations from the CATS lidar will also be presented. A feature of the CATS instrument on board the International Space Station is that it gives information at different solar viewing times to examine the diurnal variation of clouds and this provides an ability to evaluate the performance of the cloud mask for different sun angles.

Continuous Improvement in Online Education: Documenting Teaching Effectiveness in the Online Environment through Observations

ERIC Educational Resources Information Center

Purcell, Jennifer W.; Scott, Heather I.; Mixson-Brookshire, Deborah

2017-01-01

Teaching observations are commonly used among educators to document and improve teaching effectiveness. Unfortunately, the necessary protocols and supporting infrastructure are not consistently available for faculty who teach online. This paper presents a brief literature review and reflective narratives of educators representing online education…

Improved Specification of Transboundary Air Pollution over the Gulf of Mexico Using Satellite Observations

NASA Astrophysics Data System (ADS)

Pour Biazar, A.; Khan, M. N.; Park, Y. H.; McNider, R. T.; Cameron, B.

2010-12-01

The assessment of potential environmental impact of oil and gas operations in the Gulf of Mexico (GoM) and in particular the onshore air quality impact of such operations is important to State and Federal regulatory agencies. In adapting sound policies for control strategies, it is crucial to assess the impact of local pollution versus transboundary air pollution, and in a region such as GoM with scarce monitoring capability over open waters such distinctions represents a challenge. Furthermore, GoM region can be impacted by the recirculation of pollution in the southeastern United States. The current study examines the efficacy of utilizing the newly available satellite observations of aerosols and trace gases in air quality impacts assessment for addressing these issues. In particular, ozone profiles from the Tropospheric Emission Spectrometer (TES) and Ozone Monitoring Instrument (OMI) onboard Aura and aerosol products from Moderate Resolution Imaging Spectroradiometer (MODIS) onboard Terra and Aqua satellites were utilized in a modeling study during August 2006. The satellite observations were used in the specification of the background and lateral boundary and also once daily for the re-adjustment of the concentration fields. The results were then evaluated against ozonesonde and surface observations. The utilization of OMI ozone profiles significantly improved model performance in the free troposphere and the use of MODIS aerosol products substantially enhanced model prediction of aerosols in the boundary layer. Neither OMI nor TES provide adequate information in the boundary layer with respect to O3 and as a result they can only marginally impact ozone predictions in the boundary layer. The utilization of the satellite data for lateral boundary condition (BC) was helpful in the realization of transboundary transport of pollution. The hypothesis that the recirculation of pollution from Northeast Corridor can play a role over the Gulf of Mexico was tested and

OSSE Assessment of Ocean Observing System Enhancements to Improve Coupled Tropical Cyclone Intensity Prediction

NASA Astrophysics Data System (ADS)

Halliwell, G. R., Jr.; Mehari, M. F.; Dong, J.; Kourafalou, V.; Atlas, R. M.; Kang, H.; Le Henaff, M.

2016-02-01

A new ocean OSSE system validated in the tropical/subtropical Atlantic Ocean is used to evaluate ocean observing strategies during the 2014 hurricane season with the goal of improving coupled tropical cyclone forecasts. Enhancements to the existing operational ocean observing system are evaluated prior to two storms, Edouard and Gonzalo, where ocean measurements were obtained during field experiments supported by the 2013 Disaster Relief Appropriation Act. For Gonzalo, a reference OSSE is performed to evaluate the impact of two ocean gliders deployed north and south of Puerto Rico and two Alamo profiling floats deployed in the same general region during most of the hurricane season. For Edouard, a reference OSSE is performed to evaluate impacts of the pre-storm ocean profile survey conducted by NOAA WP-3D aircraft. For both storms, additional OSSEs are then conducted to evaluate more extensive seasonal and pre-storm ocean observing strategies. These include (1) deploying a larger number of synthetic ocean gliders during the hurricane season, (2) deploying pre-storm synthetic thermistor chains or synthetic profiling floats along one or more "picket fence" lines that cross projected storm tracks, and (3) designing pre-storm airborne profiling surveys to have larger impacts than the actual pre-storm survey conducted for Edouard. Impacts are evaluated based on error reduction in ocean parameters important to SST cooling and hurricane intensity such as ocean heat content and the structure of the ocean eddy field. In all cases, ocean profiles that sample both temperature and salinity down to 1000m provide greater overall error reduction than shallower temperature profiles obtained from AXBTs and thermistor chains. Large spatial coverage with multiple instruments spanning a few degrees of longitude and latitude is necessary to sufficiently reduce ocean initialization errors over a region broad enough to significantly impact predicted surface enthalpy flux into the storm

The Strasbourg Large Refractor and Dome: Significant Improvements and Failed Attempts

NASA Astrophysics Data System (ADS)

Heck, Andre

2009-01-01

Founded by the German Empire in the late 19th century, Strasbourg Astronomical Observatory featured several novelties from the start. According to Mueller (1978), the separation of observing buildings from the study area and from the astronomers' residence was a revolution in observatory construction. The instruments were, as much as possible, isolated from the vibrations of the buildings themselves. "Gas flames" and water were used to reduce temperature effects. Thus the Large Dome (ca 11m diameter), housing the Large Refractor (ca 49cm, then the largest in Germany) and covered by zinc over wood, could be cooled down by water running from the top. Reports (including by the French who took over the observatory after World War I) are however somehow nonexistent on the effective usage and actual efficiency of such a system (which must have generated locally a significant amount of humidity). The paper will detail these technical attempts as well as the specificities of the instruments installed in that new observatory intended as a showcase of German astronomy.

Significant Improvement in Chronic Persistent Headaches Caused by Small Rathke Cleft Cysts After Transsphenoidal Surgery.

PubMed

Fukui, Issei; Hayashi, Yasuhiko; Kita, Daisuke; Sasagawa, Yasuo; Oishi, Masahiro; Tachibana, Osamu; Nakada, Mitsutoshi

2017-03-01

Rathke cleft cysts (RCC) usually are asymptomatic and can be observed via the use of conservative methods. Some patients with RCCs, however, have severe headaches even if they are small enough to be confined to the sella, and these small RCCs seldom have been discussed. This study presents an investigation into clinical characteristics of small RCCs associated with severe headaches, demonstrating efficacy and safety of endoscopic transsphenoidal surgery (ETSS) to relieve headaches. In this study, 13 patients with small RCCs (maximum diameter <10 mm) who presented with headaches and were treated by ETSS at our institute from 2009 to 2014 were recruited. These RCCs were treated Headache Impact Test-6 (HIT-6) score was calculated both pre- and postoperatively to evaluate headache severity. All patients complained of severe headaches, which disturbed their daily life. Most headaches were nonpulsating and localized in the frontal area. Characteristically, 6 patients (46%) experienced severe headaches with sudden onset that continued chronically. HIT-6 score was 64 on average, meaning headaches affected daily life severely. After surgical decompression of the cyst, headache in all of the patients improved dramatically and HIT-6 score decreased significantly to 37, suggesting that headaches were diminished. No newly developed deficiencies of the anterior pituitary lobe function were detected. Postoperative occurrence of diabetes insipidus was found in 2 patients, both of which were transient. No recurring cysts were found. Severe headaches can develop from small RCCs. In the present study, ETSS was performed on such patients effectively and safely to relieve their headaches. Copyright © 2017 Elsevier Inc. All rights reserved.

Improved Understanding of the Modeled QBO Using MLS Observations and MERRA Reanalysis

NASA Technical Reports Server (NTRS)

Oman, Luke David; Douglass, Anne Ritger; Hurwitz, Maggie M.; Garfinkel, Chaim I.

2013-01-01

The Quasi-Biennial Oscillation (QBO) dominates the variability of the tropical stratosphere on interannual time scales. The QBO has been shown to extend its influence into the chemical composition of this region through dynamical mechanisms. We have started our analysis using the realistic QBO internally generated by the Goddard Earth Observing System Version 5 (GEOS-5) general circulation model coupled to a comprehensive stratospheric and tropospheric chemical mechanism forced with observed sea surface temperatures over the past 33 years. We will show targeted comparisons with observations from NASAs Aura satellite Microwave Limb Sounder (MLS) and the Modern Era Retrospective-Analysis for Research and Applications (MERRA) reanalysis to provide insight into the simulation of the primary and secondary circulations associated with the QBO. Using frequency spectrum analysis and multiple linear regression we can illuminate the resulting circulations and deduce the strengths and weaknesses in their modeled representation. Inclusion of the QBO in our simulation improves the representation of the subtropical barriers and overall tropical variability. The QBO impact on tropical upwelling is important to quantify when calculating trends in sub-decadal scale datasets.

Teacher coaching supported by formative assessment for improving classroom practices.

PubMed

Fabiano, Gregory A; Reddy, Linda A; Dudek, Christopher M

2018-06-01

The present study is a wait-list controlled, randomized study investigating a teacher coaching approach that emphasizes formative assessment and visual performance feedback to enhance elementary school teachers' classroom practices. The coaching model targeted instructional and behavioral management practices as measured by the Classroom Strategies Assessment System (CSAS) Observer and Teacher Forms. The sample included 89 general education teachers, stratified by grade level, and randomly assigned to 1 of 2 conditions: (a) immediate coaching, or (b) waitlist control. Results indicated that, relative to the waitlist control, teachers in immediate coaching demonstrated significantly greater improvements in observations of behavior management strategy use but not for observations of instructional strategy use. Observer- and teacher-completed ratings of behavioral management strategy use at postassessment were significantly improved by both raters; ratings of instructional strategy use were significantly improved for teacher but not observer ratings. A brief coaching intervention improved teachers' use of observed behavior management strategies and self-reported use of behavior management and instructional strategies. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Classroom observation data and instruction in primary mathematics education: improving design and rigour

NASA Astrophysics Data System (ADS)

Thompson, Carla J.; Davis, Sandra B.

2014-06-01

The use of formal observation in primary mathematics classrooms is supported in the literature as a viable method of determining effective teaching strategies and appropriate tasks for inclusion in the early years of mathematics learning. The twofold aim of this study was to (a) investigate predictive relationships between primary mathematics classroom observational data and student achievement data, and (b) to examine the impact of providing periodic classroom observational data feedback to teachers using a Relational-Feedback-Intervention (RFI) Database Model. This observational research effort focused on an empirical examination of student engagement levels in time spent on specific learning activities observed in primary mathematics classrooms as predictors of student competency outcomes in mathematics. Data were collected from more than 2,000 primary classroom observations in 17 primary schools during 2009-2011 and from standardised end-of-year tests for mathematics achievement. Results revealed predictive relationships among several types of teaching and learning tasks with student achievement. Specifically, the use of mathematics concepts, technology and hands-on materials in primary mathematics classrooms was found to produce substantive predictors of increased student mathematics achievement. Additional findings supported the use of periodic classroom observation data reporting as a positive influence on teachers' decisions in determining instructional tasks for inclusion in primary mathematics classrooms. Study results indicate classroom observational research involving a RFI Database Model is a productive tool for improving teaching and learning in primary mathematics classrooms.

Perceptual learning improves visual performance in juvenile amblyopia.

PubMed

Li, Roger W; Young, Karen G; Hoenig, Pia; Levi, Dennis M

2005-09-01

To determine whether practicing a position-discrimination task improves visual performance in children with amblyopia and to determine the mechanism(s) of improvement. Five children (age range, 7-10 years) with amblyopia practiced a positional acuity task in which they had to judge which of three pairs of lines was misaligned. Positional noise was produced by distributing the individual patches of each line segment according to a Gaussian probability function. Observers were trained at three noise levels (including 0), with each observer performing between 3000 and 4000 responses in 7 to 10 sessions. Trial-by-trial feedback was provided. Four of the five observers showed significant improvement in positional acuity. In those four observers, on average, positional acuity with no noise improved by approximately 32% and with high noise by approximately 26%. A position-averaging model was used to parse the improvement into an increase in efficiency or a decrease in equivalent input noise. Two observers showed increased efficiency (51% and 117% improvements) with no significant change in equivalent input noise across sessions. The other two observers showed both a decrease in equivalent input noise (18% and 29%) and an increase in efficiency (17% and 71%). All five observers showed substantial improvement in Snellen acuity (approximately 26%) after practice. Perceptual learning can improve visual performance in amblyopic children. The improvement can be parsed into two important factors: decreased equivalent input noise and increased efficiency. Perceptual learning techniques may add an effective new method to the armamentarium of amblyopia treatments.

Improving magnetosphere in situ observations using solar sails

NASA Astrophysics Data System (ADS)

Parsay, Khashayar; Schaub, Hanspeter; Schiff, Conrad; Williams, Trevor

2018-01-01

Past and current magnetosphere missions employ conventional spacecraft formations for in situ observations of the geomagnetic tail. Conventional spacecraft flying in inertially fixed Keplerian orbits are only aligned with the geomagnetic tail once per year, since the geomagnetic tail is always aligned with the Earth-Sun line, and therefore, rotates annually. Solar sails are able to artificially create sun-synchronous orbits such that the orbit apse line remains aligned with the geomagnetic tail line throughout the entire year. This continuous presence in the geomagnetic tail can significantly increase the science phase for magnetosphere missions. In this paper, the problem of solar sail formation design is explored using nonlinear programming to design optimal two-craft, triangle, and tetrahedron solar sail formations, in terms of formation quality and formation stability. The designed formations are directly compared to the formations used in NASA's Magnetospheric Multi-Scale mission.

Improving Convection and Cloud Parameterization Using ARM Observations and NCAR Community Atmosphere Model CAM5

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Guang J.

2016-11-07

The fundamental scientific objectives of our research are to use ARM observations and the NCAR CAM5 to understand the large-scale control on convection, and to develop improved convection and cloud parameterizations for use in GCMs.

Converting Soil Moisture Observations to Effective Values for Improved Validation of Remotely Sensed Soil Moisture

NASA Technical Reports Server (NTRS)

Laymon, Charles A.; Crosson, William L.; Limaye, Ashutosh; Manu, Andrew; Archer, Frank

2005-01-01

We compare soil moisture retrieved with an inverse algorithm with observations of mean moisture in the 0-6 cm soil layer. A significant discrepancy is noted between the retrieved and observed moisture. Using emitting depth functions as weighting functions to convert the observed mean moisture to observed effective moisture removes nearly one-half of the discrepancy noted. This result has important implications in remote sensing validation studies.

Carfilzomib significantly improves the progression-free survival of high-risk patients in multiple myeloma.

PubMed

Avet-Loiseau, Hervé; Fonseca, Rafael; Siegel, David; Dimopoulos, Meletios A; Špička, Ivan; Masszi, Tamás; Hájek, Roman; Rosiñol, Laura; Goranova-Marinova, Vesselina; Mihaylov, Georgi; Maisnar, Vladimír; Mateos, Maria-Victoria; Wang, Michael; Niesvizky, Ruben; Oriol, Albert; Jakubowiak, Andrzej; Minarik, Jiri; Palumbo, Antonio; Bensinger, William; Kukreti, Vishal; Ben-Yehuda, Dina; Stewart, A Keith; Obreja, Mihaela; Moreau, Philippe

2016-09-01

The presence of certain high-risk cytogenetic abnormalities, such as translocations (4;14) and (14;16) and deletion (17p), are known to have a negative impact on survival in multiple myeloma (MM). The phase 3 study ASPIRE (N = 792) demonstrated that progression-free survival (PFS) was significantly improved with carfilzomib, lenalidomide, and dexamethasone (KRd), compared with lenalidomide and dexamethasone (Rd) in relapsed MM. This preplanned subgroup analysis of ASPIRE was conducted to evaluate KRd vs Rd by baseline cytogenetics according to fluorescence in situ hybridization. Of 417 patients with known cytogenetic risk status, 100 patients (24%) were categorized with high-risk cytogenetics (KRd, n = 48; Rd, n = 52) and 317 (76%) were categorized with standard-risk cytogenetics (KRd, n = 147; Rd, n = 170). For patients with high-risk cytogenetics, treatment with KRd resulted in a median PFS of 23.1 months, a 9-month improvement relative to treatment with Rd. For patients with standard-risk cytogenetics, treatment with KRd led to a 10-month improvement in median PFS vs Rd. The overall response rates for KRd vs Rd were 79.2% vs 59.6% (high-risk cytogenetics) and 91.2% vs 73.5% (standard-risk cytogenetics); approximately fivefold as many patients with high- or standard-risk cytogenetics achieved a complete response or better with KRd vs Rd (29.2% vs 5.8% and 38.1% vs 6.5%, respectively). KRd improved but did not abrogate the poor prognosis associated with high-risk cytogenetics. This regimen had a favorable benefit-risk profile in patients with relapsed MM, irrespective of cytogenetic risk status, and should be considered a standard of care in these patients. This trial was registered at www.clinicaltrials.gov as #NCT01080391. © 2016 by The American Society of Hematology.

Carfilzomib significantly improves the progression-free survival of high-risk patients in multiple myeloma

PubMed Central

Fonseca, Rafael; Siegel, David; Dimopoulos, Meletios A.; Špička, Ivan; Masszi, Tamás; Hájek, Roman; Rosiñol, Laura; Goranova-Marinova, Vesselina; Mihaylov, Georgi; Maisnar, Vladimír; Mateos, Maria-Victoria; Wang, Michael; Niesvizky, Ruben; Oriol, Albert; Jakubowiak, Andrzej; Minarik, Jiri; Palumbo, Antonio; Bensinger, William; Kukreti, Vishal; Ben-Yehuda, Dina; Stewart, A. Keith; Obreja, Mihaela; Moreau, Philippe

2016-01-01

The presence of certain high-risk cytogenetic abnormalities, such as translocations (4;14) and (14;16) and deletion (17p), are known to have a negative impact on survival in multiple myeloma (MM). The phase 3 study ASPIRE (N = 792) demonstrated that progression-free survival (PFS) was significantly improved with carfilzomib, lenalidomide, and dexamethasone (KRd), compared with lenalidomide and dexamethasone (Rd) in relapsed MM. This preplanned subgroup analysis of ASPIRE was conducted to evaluate KRd vs Rd by baseline cytogenetics according to fluorescence in situ hybridization. Of 417 patients with known cytogenetic risk status, 100 patients (24%) were categorized with high-risk cytogenetics (KRd, n = 48; Rd, n = 52) and 317 (76%) were categorized with standard-risk cytogenetics (KRd, n = 147; Rd, n = 170). For patients with high-risk cytogenetics, treatment with KRd resulted in a median PFS of 23.1 months, a 9-month improvement relative to treatment with Rd. For patients with standard-risk cytogenetics, treatment with KRd led to a 10-month improvement in median PFS vs Rd. The overall response rates for KRd vs Rd were 79.2% vs 59.6% (high-risk cytogenetics) and 91.2% vs 73.5% (standard-risk cytogenetics); approximately fivefold as many patients with high- or standard-risk cytogenetics achieved a complete response or better with KRd vs Rd (29.2% vs 5.8% and 38.1% vs 6.5%, respectively). KRd improved but did not abrogate the poor prognosis associated with high-risk cytogenetics. This regimen had a favorable benefit-risk profile in patients with relapsed MM, irrespective of cytogenetic risk status, and should be considered a standard of care in these patients. This trial was registered at www.clinicaltrials.gov as #NCT01080391. PMID:27439911

Assessing video games to improve driving skills: a literature review and observational study.

PubMed

Sue, Damian; Ray, Pradeep; Talaei-Khoei, Amir; Jonnagaddala, Jitendra; Vichitvanichphong, Suchada

2014-08-07

For individuals, especially older adults, playing video games is a promising tool for improving their driving skills. The ease of use, wide availability, and interactivity of gaming consoles make them an attractive simulation tool. The objective of this study was to look at the feasibility and effects of installing video game consoles in the homes of individuals looking to improve their driving skills. A systematic literature review was conducted to assess the effect of playing video games on improving driving skills. An observatory study was performed to evaluate the feasibility of using an Xbox 360 Kinect console for improving driving skills. Twenty-nine articles, which discuss the implementation of video games in improving driving skills were found in literature. On our study, it was found the Xbox 360 with Kinect is capable of improving physical and mental activities. Xbox Video games were introduced to engage players in physical, visual and cognitive activities including endurance, postural sway, reaction time, eyesight, eye movement, attention and concentration, difficulties with orientation, and semantic fluency. However, manual dexterity, visuo-spatial perception and binocular vision could not be addressed by these games. It was observed that Xbox Kinect (by incorporating Kinect sensor facilities) combines physical, visual and cognitive engagement of players. These results were consistent with those from the literature review. From the research that has been carried out, we can conclude that video game consoles are a viable solution for improving user's physical and mental state. In future we propose to carry a thorough evaluation of the effects of video games on driving skills in elderly people.

The Quake-Catcher Network: Improving Earthquake Strong Motion Observations Through Community Engagement

NASA Astrophysics Data System (ADS)

Cochran, E. S.; Lawrence, J. F.; Christensen, C. M.; Chung, A. I.; Neighbors, C.; Saltzman, J.

2010-12-01

The Quake-Catcher Network (QCN) involves the community in strong motion data collection by utilizing volunteer computing techniques and low-cost MEMS accelerometers. Volunteer computing provides a mechanism to expand strong-motion seismology with minimal infrastructure costs, while promoting community participation in science. Micro-Electro-Mechanical Systems (MEMS) triaxial accelerometers can be attached to a desktop computer via USB and are internal to many laptops. Preliminary shake table tests show the MEMS accelerometers can record high-quality seismic data with instrument response similar to research-grade strong-motion sensors. QCN began distributing sensors and software to K-12 schools and the general public in April 2008 and has grown to roughly 1500 stations worldwide. We also recently tested whether sensors could be quickly deployed as part of a Rapid Aftershock Mobilization Program (RAMP) following the 2010 M8.8 Maule, Chile earthquake. Volunteers are recruited through media reports, web-based sensor request forms, as well as social networking sites. Using data collected to date, we examine whether a distributed sensing network can provide valuable seismic data for earthquake detection and characterization while promoting community participation in earthquake science. We utilize client-side triggering algorithms to determine when significant ground shaking occurs and this metadata is sent to the main QCN server. On average, trigger metadata are received within 1-10 seconds from the observation of a trigger; the larger data latencies are correlated with greater server-station distances. When triggers are detected, we determine if the triggers correlate to others in the network using spatial and temporal clustering of incoming trigger information. If a minimum number of triggers are detected then a QCN-event is declared and an initial earthquake location and magnitude is estimated. Initial analysis suggests that the estimated locations and magnitudes are

Significance of preoperatively observed detrusor overactivity as a predictor of continence status early after robot-assisted radical prostatectomy

PubMed Central

Yanagiuchi, Akihiro; Miyake, Hideaki; Tanaka, Kazushi; Fujisawa, Masato

2014-01-01

Several recent studies have reported the involvement of bladder dysfunction in the delayed recovery of urinary continence following radical prostatectomy (RP). The objective of this study was to investigate the significance of detrusor overactivity (DO) as a predictor of the early continence status following robot-assisted RP (RARP). This study included 84 consecutive patients with prostate cancer undergoing RARP. Urodynamic studies, including filling cystometry, pressure flow study, electromyogram of the external urethral sphincter and urethral pressure profile, were performed in these patients before surgery. Urinary continence was defined as the use of either no or one pad per day as a precaution only. DO was preoperatively observed in 30 patients (35.7%), and 55 (65.5%) and 34 (40.5%) were judged to be incontinent 1 and 3 months after RARP, respectively. At both 1 and 3 months after RARP, the incidences of incontinence in patients with DO were significantly higher than in those without DO. Of several demographic and urodynamic parameters, univariate analyses identified DO and maximal urethral closure pressure (MUCP) as significant predictors of the continence status at both 1 and 3 months after RARP. Furthermore, DO and MUCP appeared to be independently associated with the continence at both 1 and 3 months after RARP on multivariate analysis. These findings suggest that preoperatively observed DO could be a significant predictor of urinary incontinence early after RARP; therefore, it is recommended to perform urodynamic studies for patients who are scheduled to undergo RARP in order to comprehensively evaluate their preoperative vesicourethral functions. PMID:25038181

Integration of biomimicry and nanotechnology for significantly improved detection of circulating tumor cells (CTCs).

PubMed

Myung, Ja Hye; Park, Sin-Jung; Wang, Andrew Z; Hong, Seungpyo

2017-12-13

Circulating tumor cells (CTCs) have received a great deal of scientific and clinical attention as a biomarker for diagnosis and prognosis of many types of cancer. Given their potential significance in clinics, a variety of detection methods, utilizing the recent advances in nanotechnology and microfluidics, have been introduced in an effort of achieving clinically significant detection of CTCs. However, effective detection and isolation of CTCs still remain a tremendous challenge due to their extreme rarity and phenotypic heterogeneity. Among many approaches that are currently under development, this review paper focuses on a unique, promising approach that takes advantages of naturally occurring processes achievable through application of nanotechnology to realize significant improvement in sensitivity and specificity of CTC capture. We provide an overview of successful outcome of this biomimetic CTC capture system in detection of tumor cells from in vitro, in vivo, and clinical pilot studies. We also emphasize the clinical impact of CTCs as biomarkers in cancer diagnosis and predictive prognosis, which provides a cost-effective, minimally invasive method that potentially replaces or supplements existing methods such as imaging technologies and solid tissue biopsy. In addition, their potential prognostic values as treatment guidelines and that ultimately help to realize personalized therapy are discussed. Copyright © 2017. Published by Elsevier B.V.

Improved SOT (Hinode mission) high resolution solar imaging observations

NASA Astrophysics Data System (ADS)

Goodarzi, H.; Koutchmy, S.; Adjabshirizadeh, A.

2015-08-01

We consider the best today available observations of the Sun free of turbulent Earth atmospheric effects, taken with the Solar Optical Telescope (SOT) onboard the Hinode spacecraft. Both the instrumental smearing and the observed stray light are analyzed in order to improve the resolution. The Point Spread Function (PSF) corresponding to the blue continuum Broadband Filter Imager (BFI) near 450 nm is deduced by analyzing (i) the limb of the Sun and (ii) images taken during the transit of the planet Venus in 2012. A combination of Gaussian and Lorentzian functions is selected to construct a PSF in order to remove both smearing due to the instrumental diffraction effects (PSF core) and the large-angle stray light due to the spiders and central obscuration (wings of the PSF) that are responsible for the parasitic stray light. A Max-likelihood deconvolution procedure based on an optimum number of iterations is discussed. It is applied to several solar field images, including the granulation near the limb. The normal non-magnetic granulation is compared to the abnormal granulation which we call magnetic. A new feature appearing for the first time at the extreme- limb of the disk (the last 100 km) is discussed in the context of the definition of the solar edge and of the solar diameter. A single sunspot is considered in order to illustrate how effectively the restoration works on the sunspot core. A set of 125 consecutive deconvolved images is assembled in a 45 min long movie illustrating the complexity of the dynamical behavior inside and around the sunspot.

Water level observations from Unmanned Aerial Vehicles (UAVs) for improving probabilistic estimations of interaction between rivers and groundwater

NASA Astrophysics Data System (ADS)

Bandini, Filippo; Butts, Michael; Vammen Jacobsen, Torsten; Bauer-Gottwein, Peter

2016-04-01

efficient global Markov Chain Monte Carlo (MCMC) in high-dimensional spaces. Calibration against water level has demonstrated a significant improvement of the estimation of the exchange flow between groundwater and river branch. Groundwater flux and direction are now better simulated. Reliability and sharpness of the probabilistic forecasts are assessed with the sharpness, the interval skill score (ISS) of the 95{%} confidence interval, and with the root mean square error (RMSE) of the maximum a posteriori probability (MAP). The binary outcome (either gaining or loosing stream) of the flow direction is assessed with Brier score (BS). After water level calibration the sharpness of the estimations is approximately doubled with respect to the model calibrated only against discharge, ISS has improved from 2.4-7to 7.8-8 m^3/s\\cdot m, RMSE from 9.2-8 to 2.4-8 m^3/s\\cdot m^and BS is halved from 0.58 to 0.25.

AERONET Version 3 Release: Providing Significant Improvements for Multi-Decadal Global Aerosol Database and Near Real-Time Validation

NASA Technical Reports Server (NTRS)

Holben, Brent; Slutsker, Ilya; Giles, David; Eck, Thomas; Smirnov, Alexander; Sinyuk, Aliaksandr; Schafer, Joel; Sorokin, Mikhail; Rodriguez, Jon; Kraft, Jason;

Formulation of immunoassay calibrators in pasteurized albumin can significantly enhance their durability.

PubMed

Warren, David J; Nordlund, Marianne S; Paus, Elisabeth

2010-02-28

Calibrator matrix can have significant effects on the commutability of assay standards and on the maintenance of their integrity. We have observed marked instability in progastrin-releasing peptide (proGRP) assay standards traceable to the bovine serum albumin (BSA) used in matrix formulation. Attempts were made to improve calibrator stability using different albumin pretreatments. Observed analyte recoveries in calibrators prepared with untreated BSA were consistently less than 45% after 1 week of storage at 4 degrees C. Pre-treating the BSA by chromatography on immobilized heparin or benzamidine failed to improve calibrator durability with day 7 recoveries of less than 55%. In marked contrast, calibrators formulated with albumin pasteurized at pH 3.0 displayed remarkable stability. Recoveries of >97% were observed after 4 weeks of storage at either 4 degrees C or room temperature. Even calibrators incubated for 4 weeks at 37 degrees C gave recoveries between 91-106%. This improvement was not seen with BSA pasteurized at neutral pH. Albumin pretreatment is straightforward, easily scalable and dramatically improves calibrator stability. Matrix formulated with acid-pasteurized BSA may prove more generally useful when assays are plagued by poor calibrator durability. 2009 Elsevier B.V. All rights reserved.

A novel teaching tool using dynamic cues improves visualisation of chest lesions by naive observers

NASA Astrophysics Data System (ADS)

Mohamed Ali, M. A.; Toomey, R. J.; Ryan, J. T.; Cuffe, F. C.; Brennan, P. C.

2009-02-01

Introduction Dynamic cueing is an effective way of stimulating perception of regions of interest within radiological images. This study explores the impact of a novel teaching tool using dynamic cueing for lesion detection on plain chest radiographs. Materials and methods Observer performance studies were carried out where 36 novices examined 30 chest images in random order. Half of these contained between one and three simulated pulmonary nodules. Three groups were investigated: A (control: no teaching tool), B (retested immediately after undergoing the teaching tool) and C (retested a week after undergoing the teaching tool). The teaching tool involved dynamically displaying the same images with and without lesions. Results were compared using Receiver Operating Characteristics (ROC), sensitivity and specificity analyses. Results The second reading showed significantly greater area under the ROC curve (Az value) (p<0.0001) and higher sensitivity value (p=0.004) compared to the first reading for Group B. No differences between readings were demonstrated for groups A or C. When the magnitudes of the above changes were compared between Group B and the other two groups, greater changes in Az value for Group B were noted (B vs. A:p=0.0003, B vs. C:p=0.0005). For sensitivity, when Group B was compared to Group A, the magnitude of the change was significantly greater (p=0.0029) whereas when Group B was compared to Group C, the magnitude change demonstrated a level approaching significance (p=0.0768). Conclusions The novel teaching tool improves identification of pulmonary nodular lesions on chest radiographs in the short term.

Low-dose vaporized cannabis significantly improves neuropathic pain.

PubMed

Wilsey, Barth; Marcotte, Thomas; Deutsch, Reena; Gouaux, Ben; Sakai, Staci; Donaghe, Haylee

2013-02-01

We conducted a double-blind, placebo-controlled, crossover study evaluating the analgesic efficacy of vaporized cannabis in subjects, the majority of whom were experiencing neuropathic pain despite traditional treatment. Thirty-nine patients with central and peripheral neuropathic pain underwent a standardized procedure for inhaling medium-dose (3.53%), low-dose (1.29%), or placebo cannabis with the primary outcome being visual analog scale pain intensity. Psychoactive side effects and neuropsychological performance were also evaluated. Mixed-effects regression models demonstrated an analgesic response to vaporized cannabis. There was no significant difference between the 2 active dose groups' results (P > .7). The number needed to treat (NNT) to achieve 30% pain reduction was 3.2 for placebo versus low-dose, 2.9 for placebo versus medium-dose, and 25 for medium- versus low-dose. As these NNTs are comparable to those of traditional neuropathic pain medications, cannabis has analgesic efficacy with the low dose being as effective a pain reliever as the medium dose. Psychoactive effects were minimal and well tolerated, and neuropsychological effects were of limited duration and readily reversible within 1 to 2 hours. Vaporized cannabis, even at low doses, may present an effective option for patients with treatment-resistant neuropathic pain. The analgesia obtained from a low dose of delta-9-tetrahydrocannabinol (1.29%) in patients, most of whom were experiencing neuropathic pain despite conventional treatments, is a clinically significant outcome. In general, the effect sizes on cognitive testing were consistent with this minimal dose. As a result, one might not anticipate a significant impact on daily functioning. Published by Elsevier Inc.

Community-based peer support significantly improves metabolic control in people with Type 2 diabetes in Yaoundé, Cameroon.

PubMed

Assah, F K; Atanga, E N; Enoru, S; Sobngwi, E; Mbanya, J C

2015-07-01

To examine the effectiveness of a community-based multilevel peer support intervention in addition to usual diabetes care on improving glycaemic levels, blood pressure and lipids in patients with Type 2 diabetes in Yaoundé, Cameroon. A total of 96 subjects with poorly controlled Type 2 diabetes (intervention group) and 96 age- and sex-matched controls were recruited and followed up over 6 months. The intervention subjects underwent a peer support intervention through peer-led group meetings, personal encounters and telephone calls. Both intervention subjects and controls continued their usual clinical care. HbA1c , blood pressure, blood lipids and self-care behaviours were measured at 0 and 6 months. There was significant reduction in HbA1c in the intervention group [-33 mmol/mol (-3.0%)] compared with controls [-14 mmol/mol (-1.3%)]; P < 0.001. Peer support also led to significant reductions in fasting blood sugar (-0.83 g/l P < 0.001), cholesterol (-0.54 g/l P < 0.001), HDL (-0.09 g/l, P < 0.001), BMI (-2.71 kg/m² P < 0.001) and diastolic pressure (-6.77 mmHg, P < 0.001) over the 6-month period. Also, diabetes self-care behaviours in the intervention group improved significantly over the 6 months of peer support. Community-based peer support, in addition to usual care, significantly improved metabolic control in patients with uncontrolled Type 2 diabetes in Yaoundé, Cameroon. This could provide a model for optimizing diabetes care and control in other settings with limited healthcare and financial resources. © 2015 The Authors. Diabetic Medicine © 2015 Diabetes UK.

Assessing Video Games to Improve Driving Skills: A Literature Review and Observational Study

PubMed Central

Sue, Damian; Vichitvanichphong, Suchada

2014-01-01

Background For individuals, especially older adults, playing video games is a promising tool for improving their driving skills. The ease of use, wide availability, and interactivity of gaming consoles make them an attractive simulation tool. Objective The objective of this study was to look at the feasibility and effects of installing video game consoles in the homes of individuals looking to improve their driving skills. Methods A systematic literature review was conducted to assess the effect of playing video games on improving driving skills. An observatory study was performed to evaluate the feasibility of using an Xbox 360 Kinect console for improving driving skills. Results Twenty–nine articles, which discuss the implementation of video games in improving driving skills were found in literature. On our study, it was found the Xbox 360 with Kinect is capable of improving physical and mental activities. Xbox Video games were introduced to engage players in physical, visual and cognitive activities including endurance, postural sway, reaction time, eyesight, eye movement, attention and concentration, difficulties with orientation, and semantic fluency. However, manual dexterity, visuo-spatial perception and binocular vision could not be addressed by these games. It was observed that Xbox Kinect (by incorporating Kinect sensor facilities) combines physical, visual and cognitive engagement of players. These results were consistent with those from the literature review. Conclusions From the research that has been carried out, we can conclude that video game consoles are a viable solution for improving user’s physical and mental state. In future we propose to carry a thorough evaluation of the effects of video games on driving skills in elderly people. PMID:25654355

Improving CCTA-based lesions' hemodynamic significance assessment by accounting for partial volume modeling in automatic coronary lumen segmentation.

PubMed

Freiman, Moti; Nickisch, Hannes; Prevrhal, Sven; Schmitt, Holger; Vembar, Mani; Maurovich-Horvat, Pál; Donnelly, Patrick; Goshen, Liran

2017-03-01

The goal of this study was to assess the potential added benefit of accounting for partial volume effects (PVE) in an automatic coronary lumen segmentation algorithm that is used to determine the hemodynamic significance of a coronary artery stenosis from coronary computed tomography angiography (CCTA). Two sets of data were used in our work: (a) multivendor CCTA datasets of 18 subjects from the MICCAI 2012 challenge with automatically generated centerlines and 3 reference segmentations of 78 coronary segments and (b) additional CCTA datasets of 97 subjects with 132 coronary lesions that had invasive reference standard FFR measurements. We extracted the coronary artery centerlines for the 97 datasets by an automated software program followed by manual correction if required. An automatic machine-learning-based algorithm segmented the coronary tree with and without accounting for the PVE. We obtained CCTA-based FFR measurements using a flow simulation in the coronary trees that were generated by the automatic algorithm with and without accounting for PVE. We assessed the potential added value of PVE integration as a part of the automatic coronary lumen segmentation algorithm by means of segmentation accuracy using the MICCAI 2012 challenge framework and by means of flow simulation overall accuracy, sensitivity, specificity, negative and positive predictive values, and the receiver operated characteristic (ROC) area under the curve. We also evaluated the potential benefit of accounting for PVE in automatic segmentation for flow simulation for lesions that were diagnosed as obstructive based on CCTA which could have indicated a need for an invasive exam and revascularization. Our segmentation algorithm improves the maximal surface distance error by ~39% compared to previously published method on the 18 datasets from the MICCAI 2012 challenge with comparable Dice and mean surface distance. Results with and without accounting for PVE were comparable. In contrast

Continuous Flow Left Ventricular Assist Device Implant Significantly Improves Pulmonary Hypertension, Right Ventricular Contractility, and Tricuspid Valve Competence

PubMed Central

Atluri, Pavan; Fairman, Alexander S.; MacArthur, John W.; Goldstone, Andrew B.; Cohen, Jeffrey E.; Howard, Jessica L.; Zalewski, Christyna M.; Shudo, Yasuhiro; Woo, Y. Joseph

2014-01-01

Background Continuous flow left ventricular assist devices (CF LVAD) are being implanted with increasing frequency for end-stage heart failure. At the time of LVAD implant, a large proportion of patients have pulmonary hypertension, right ventricular (RV) dysfunction, and tricuspid regurgitation (TR). RV dysfunction and TR can exacerbate renal dysfunction, hepatic dysfunction, coagulopathy, edema, and even prohibit isolated LVAD implant. Repairing TR mandates increased cardiopulmonary bypass time and bicaval cannulation, which should be reserved for the time of orthotopic heart transplantation. We hypothesized that CF LVAD implant would improve pulmonary artery pressures, enhance RV function, and minimize TR, obviating need for surgical tricuspid repair. Methods One hundred fourteen continuous flow LVADs implanted from 2005 through 2011 at a single center, with medical management of functional TR, were retrospectively analyzed. Pulmonary artery pressures were measured immediately prior to and following LVAD implant. RV function and TR were graded according to standard echocardiographic criteria, prior to, immediately following, and long-term following LVAD. Results There was a significant improvement in post-VAD mean pulmonary arterial pressures (26.6 ± 4.9 vs. 30.2 ± 7.4 mmHg, p = 0.008) with equivalent loading pressures (CVP = 12.0 ± 4.0 vs. 12.1 ± 5.1 p = NS). RV function significantly improved, as noted by right ventricular stroke work index (7.04 ± 2.60 vs. 6.05 ± 2.54, p = 0.02). There was an immediate improvement in TR grade and RV function following LVAD implant, which was sustained long term. Conclusion Continuous flow LVAD implant improves pulmonary hypertension, RV function, and tricuspid regurgitation. TR may be managed nonoperatively during CF LVAD implant. PMID:24118109

Complete Au@ZnO core-shell nanoparticles with enhanced plasmonic absorption enabling significantly improved photocatalysis

NASA Astrophysics Data System (ADS)

Sun, Yiqiang; Sun, Yugang; Zhang, Tao; Chen, Guozhu; Zhang, Fengshou; Liu, Dilong; Cai, Weiping; Li, Yue; Yang, Xianfeng; Li, Cuncheng

2016-05-01

Nanostructured ZnO exhibits high chemical stability and unique optical properties, representing a promising candidate among photocatalysts in the field of environmental remediation and solar energy conversion. However, ZnO only absorbs the UV light, which accounts for less than 5% of total solar irradiation, significantly limiting its applications. In this article, we report a facile and efficient approach to overcome the poor wettability between ZnO and Au by carefully modulating the surface charge density on Au nanoparticles (NPs), enabling rapid synthesis of Au@ZnO core-shell NPs at room temperature. The resulting Au@ZnO core-shell NPs exhibit a significantly enhanced plasmonic absorption in the visible range due to the Au NP cores. They also show a significantly improved photocatalytic performance in comparison with their single-component counterparts, i.e., the Au NPs and ZnO NPs. Moreover, the high catalytic activity of the as-synthesized Au@ZnO core-shell NPs can be maintained even after many cycles of photocatalytic reaction. Our results shed light on the fact that the Au@ZnO core-shell NPs represent a promising class of candidates for applications in plasmonics, surface-enhanced spectroscopy, light harvest devices, solar energy conversion, and degradation of organic pollutants.Nanostructured ZnO exhibits high chemical stability and unique optical properties, representing a promising candidate among photocatalysts in the field of environmental remediation and solar energy conversion. However, ZnO only absorbs the UV light, which accounts for less than 5% of total solar irradiation, significantly limiting its applications. In this article, we report a facile and efficient approach to overcome the poor wettability between ZnO and Au by carefully modulating the surface charge density on Au nanoparticles (NPs), enabling rapid synthesis of Au@ZnO core-shell NPs at room temperature. The resulting Au@ZnO core-shell NPs exhibit a significantly enhanced plasmonic

Clinical leadership: using observations of care to focus risk management and quality improvement activities in the clinical setting.

PubMed

Ferguson, Lorraine; Calvert, Judy; Davie, Marilyn; Fallon, Mark; Fred, Nada; Gersbach, Vicki; Sinclair, Lynn

2007-04-01

In an era when patient safety and quality of care are a daily concern for health care professionals, it is important for nurse managers and other clinical leaders to have a repertoire of skills and interventions that can be used to motivate and engage clinical teams in risk assessment and continuous quality improvement at the level of patient care delivery. This paper describes how a cohort of clinical leaders who were undertaking a leadership development program used a relatively simple, patient-focused intervention called the 'observation of care' to help focus the clinical team's attention on areas for improvement within the clinical setting. The main quality and safety themes arising out of the observations that were undertaken by the Clinical Leaders (CLs) were related to the environment, occupational health and safety, communication and team function, clinical practice and patient care. The observations of care also provided the CLs with many opportunities to acknowledge and celebrate exemplary practice as it was observed as a means of enhancing the development of a quality and safety culture within the clinical setting. The 'observation of care' intervention can be used by Clinical Leader's to engage and motivate clinical teams to focus on continuously improving the safety and quality of their own work environment and the care delivered to patients within that environment.

On the Reprocessing and Reanalysis of Observations for Climate

NASA Technical Reports Server (NTRS)

Bosilovich, Michael G.; Kennedy, John; Dee, Dick; ONeill, Alan

2012-01-01

The long observational record is critical to our understanding of the Earth s climate, but most observing systems were not developed with a climate objective in mind. As a result, tremendous efforts have gone into assessing and reprocessing the data records to improve their usefulness in climate studies. Many challenges remain, such as tracking the improvement of processing algorithms and limited spatial coverage. Reanalyses have fostered significant research, yet reliable global trends in many physical fields are not yet attainable, despite significant advances in data assimilation and numerical modeling. Communication of the strengths, limitations and uncertainties of reprocessed observations and reanalysis data, not only among the community of developers, but also with the extended research community, including the new generations of researchers and the decision makers is crucial for further advancement of the observational data records. WCRP provides the means to bridge the different motivating objectives on which national efforts focus.

Observing the epoch of galaxy formation

PubMed Central

Steidel, Charles C.

1999-01-01

Significant observational progress in addressing the question of the origin and early evolution of galaxies has been made in the past few years, allowing for direct comparison of the epoch when most of the stars in the universe were forming to prevailing theoretical models. There is currently broad consistency between theoretical expectations and the observations, but rapid improvement in the data will provide much more critical tests of theory in the coming years. PMID:10200244

Observing the epoch of galaxy formation.

PubMed

Steidel, C C

1999-04-13

Significant observational progress in addressing the question of the origin and early evolution of galaxies has been made in the past few years, allowing for direct comparison of the epoch when most of the stars in the universe were forming to prevailing theoretical models. There is currently broad consistency between theoretical expectations and the observations, but rapid improvement in the data will provide much more critical tests of theory in the coming years.

Creating Significant Learning Experiences across Disciplines

ERIC Educational Resources Information Center

Levine, Laura E.; Fallahi, Carolyn R.; Nicoll-Senft, Joan M.; Tessier, Jack T.; Watson, Cheryl L.; Wood, Rebecca M.

2008-01-01

The purpose of this study was to use Fink's (2003) taxonomy of significant learning to redesign courses and assess student learning. Significant improvements were found across the semester for students in the six courses, but there were differences in which taxa showed improvement in each course. The meta-analysis showed significant, positive…

What Principals Do to Improve Teaching and Learning: Comparing the Use of Informal Classroom Observations in Two School Districts

ERIC Educational Resources Information Center

Ing, Marsha

2013-01-01

Informally observing classrooms is one way that principals can help improve teaching and learning. This study describes the variability of principals' classroom observations across schools and identifies the conditions under which observations relate to the instructional climate in some schools and not others. Data for this study come from…

Transient deformation of karst aquifers observed by GPS: improved knowledge from Central Apennines (Italy)

NASA Astrophysics Data System (ADS)

Silverii, F.; D'Agostino, N.; Borsa, A. A.

2017-12-01

The redistribution of water masses due to temporal variations of hydrological conditions can produce observable deformation of the shallow crust. Space geodesy, e.g., GPS and InSAR, has provided a considerable improvement in terms of data accuracy and spatial and temporal resolution for the detection and investigation of this kind of deformation. In particular, in the areas where snow and water accumulate for long periods, such as aquifers, relatively high deformation (up to several millimeters) has been observed. Karst aquifers are able to store huge amounts of water and a clear deformation related to the groundwater storage variations has been observed in some regions. In a recent study we showed that the karst aquifers of Southern Apennines deform in response of seasonal and interannual variations of groundwater content, producing a visible transient signal in the time series of the surrounding GPS sites. In this work, we analyze the GPS time series and hydrological data of Central Italy, an interesting and complex area which hosts huge karst aquifers and is characterized by high seismic activity. We show that a noticeable transient signal with features similar to those of Southern Apennines affects also the time series of Central Apennines, suggesting that the large karst aquifers of this region experience a process analogue to the ones in Southern Italy. Thanks to the availability of a dense GPS network and different kinds of hydrological data (rainfall, spring discharge, groundwater level) we focus on the process causing the observed deformation. In particular, we model the observed deformation by inverting the GPS data using Green's functions for finite strain cuboid sources (Barbot et al. 2017). An enhanced understanding of the causes and implications of the highlighted deformation of karst aquifers is of primary interest for an improved management of this important water resource and for a better understanding of the possible interactions between

Significant effect of NSP-ase enzyme supplementation in sunflower meal-based diet on the growth and nutrient digestibility in broilers.

PubMed

Bilal, M; Mirza, M A; Kaleem, M; Saeed, M; Reyad-Ul-Ferdous, Md; Abd El-Hack, M E

2017-04-01

The response of broiler chickens to 3 levels of sunflower meal and 2 levels of NSP-ase enzyme combination (with and without) was investigated in 3 × 2 factorial arrangement under complete randomized design (CRD). A total of 240 Hubbard broiler chicks were fed on practical mash diets having 2950 kcal of ME and 21% CP from 1 to 42 days of age. The BW gain was not significantly reduced when 25% SFM was added in the diets during 1 to 42 days of age. Supplementation of NSP-ase in broiler diets (day 1-42 overall) demonstrated non-significant differences (p < 0.05) across the treatments in terms of FI and BWG. The difference in feed:gain at 15% or 20% SFM was observed to be non-significant. Replacement of SBM with SFM or inclusion of SFM at higher level (25%) increased/deteriorated FCR. The addition of exogenous NSP-ase showed a significant improvement (p < 0.01) in feed:gain. The improvement was clearly demonstrated when SFM was added to the experimental diet at 15% or even 20%. Supplementation of NSP-ase at the 25% inclusion level could not, however, sustain the beneficial effect, which was possibly due to excessively high dietary CF. No difference was noted across the treatments regarding carcass response. Relative gizzard weight and intestinal weight were observed to be improved in birds consuming higher levels of SFM (p = 0.00). The digestibility of CF was observed to improve when SFM was used at 20% and 25% in the diets. No improvement in the digestibility of CF was observed with NSP-ase supplementation, which meant other factors were clearly involved. Supplementation of NSP-ase improved FCR up to 20% SFM. At 25% SFM, no improvement in the digestibility of CF was observed with NSP-ase supplementation. Journal of Animal Physiology and Animal Nutrition © 2016 Blackwell Verlag GmbH.

Additional Arctic observations improve weather and sea-ice forecasts for the Northern Sea Route

PubMed Central

Inoue, Jun; Yamazaki, Akira; Ono, Jun; Dethloff, Klaus; Maturilli, Marion; Neuber, Roland; Edwards, Patti; Yamaguchi, Hajime

2015-01-01

During ice-free periods, the Northern Sea Route (NSR) could be an attractive shipping route. The decline in Arctic sea-ice extent, however, could be associated with an increase in the frequency of the causes of severe weather phenomena, and high wind-driven waves and the advection of sea ice could make ship navigation along the NSR difficult. Accurate forecasts of weather and sea ice are desirable for safe navigation, but large uncertainties exist in current forecasts, partly owing to the sparse observational network over the Arctic Ocean. Here, we show that the incorporation of additional Arctic observations improves the initial analysis and enhances the skill of weather and sea-ice forecasts, the application of which has socioeconomic benefits. Comparison of 63-member ensemble atmospheric forecasts, using different initial data sets, revealed that additional Arctic radiosonde observations were useful for predicting a persistent strong wind event. The sea-ice forecast, initialised by the wind fields that included the effects of the observations, skilfully predicted rapid wind-driven sea-ice advection along the NSR. PMID:26585690

Anti-CD30 antibody conjugated liposomal doxorubicin with significantly improved therapeutic efficacy against anaplastic large cell lymphoma

PubMed Central

Molavi, Ommoleila; Xiong, Xiao-Bing; Douglas, Donna; Kneteman, Norm; Nagata, Satoshi; Pastan, Ira; Chu, Quincy

2013-01-01

The use of nano-carriers has been shown to improve the delivery and efficacy of chemotherapeutic agents in cancer patients. Recent studies suggest that decoration of the surface of nano-carriers with various targeting moieties may further improve the overall therapeutic efficacy. In this study, we compared the therapeutic efficacy of Doxil® (commercial doxorubicin-loaded liposomes) and that of Doxil® conjugated with anti-CD30 antibodies (CD30-targeted Doxil®) in treating anaplastic large cell lymphoma (ALCL), a type of T-cell lymphoma characterized by a high CD30 expression. Compared to Doxil®, the CD30-targeted Doxil® showed a significantly higher binding affinity to ALCL cells (5.3% versus 27%, p=0.005) and a lower inhibitory concentration at 50% (IC50) in-vitro (32.6 μg/mL versus 12.6 μg/mL, p=0.006). In a SCID mouse xenograft model, CD30-targeted Doxil® inhibited tumor growth more significantly than the unconjugated formulation; specifically, tumors in mice treated with CD30-targeted Doxil® were significantly smaller than those in mice treated with Doxil® (average, 117 mm3 vs. 270 mm3, p=0.001) at 18 days after the tumors were inoculated. Our findings have provided the proof-of-principle of using CD30-targeted nano-carriers to treat cancers that are characterized by a high level of CD30 expression, such as ALCL. PMID:23942212

The effects of action observation training and mirror therapy on gait and balance in stroke patients.

PubMed

Lee, Ho Jeong; Kim, Young Mi; Lee, Dong Kyu

2017-03-01

[Purpose] The aim of this study was to evaluate the effects of action observation training and mirror therapy to improve on balance and gait function of stroke patients. [Subjects and Methods] The participants were randomly allocated to one of three groups: The action observation training with activity group practiced additional action observation training with activity for three 30-minute session for six weeks (n=12). The mirror therapy with activity group practiced additional mirror therapy with activity for three 30-minute sessions for six weeks (n=11). The only action observation training group practiced additional action observation training for three 30-minute sessions for weeks (n=12). All groups received conventional therapy for five 60-minute sessions over a six-week period. [Results] There were significant improvements in balance and gait function. The action observation training with activity group significantly improved subjects' static balance. The action observation training with activity group and the mirror therapy with activity group significantly improved subjects' gait ability. [Conclusion] The activation of mirror neurons combined with a conventional stroke physiotherapy program enhances lower-extremity motor recovery and motor functioning in stroke patients.

The Use of Intraoperative Sensors Significantly Increases the Patient-Reported Rate of Improvement in Primary Total Knee Arthroplasty.

PubMed

Chow, James C; Breslauer, Leigh

2017-07-01

Albeit multifactorial, patient satisfaction is predominantly driven by postoperative pain and function. Unfortunately, approximately 20% of total knee arthroplasty (TKA) recipients are dissatisfied with the outcome of their surgery. Objective balancing of the soft tissue envelope may contribute to significant decrease in pain and increase in function when compared with traditional subjective methods. In an effort to confirm this, a cohort of manual TKA patient outcomes was compared with sensor-assisted TKA outcomes. One hundred fourteen patients (57 manual, 57 sensor assisted) received primary TKA. Both cohorts were matched for confounding variables. The dependent variables in this study were 6-month patient-reported outcome measures, including Knee Society Score and Oxford Knee Score. The range of motion and incidence of arthrofibrosis were also captured for both cohorts. The rate of improvement of all patient-reported outcome scores and subscores and range of motion was significantly higher in the sensor-assisted cohort. The rate of arthrofibrosis was lower in the sensor-assisted cohort but not statistically significant. The authors rejected the null hypothesis and concluded that the rate of improvement in objective, patient-reported outcome measures was higher in the sensor-assisted cohort than the manual cohort from preoperatively to 6 months postoperatively. [Orthopedics. 2017; 40(4):e648-e651.]. Copyright 2017, SLACK Incorporated.

Science Journals in the Garden: Developing the Skill of Observation in Elementary Age Students

NASA Astrophysics Data System (ADS)

Kelly, Karinsa Michelle

The ability to make and record scientific observations is critical in order for students to engage in successful inquiry, and provides a sturdy foundation for children to develop higher order cognitive processes. Nevertheless, observation is taken for granted in the elementary classroom. This study explores how linking school garden experience with the use of science journals can support this skill. Students participated in a month-long unit in which they practiced their observation skills in the garden and recorded those observations in a science journal. Students' observational skills were assessed using pre- and post-assessments, student journals, and student interviews using three criteria: Accuracy, Detail, and Quantitative Data. Statistically significant improvements were found in the categories of Detail and Quantitative Data. Scores did improve in the category of Accuracy, but it was not found to be a statistically significant improvement.

Combined training improves walking mobility in persons with significant disability from multiple sclerosis: a pilot study.

PubMed

Motl, Robert W; Smith, Douglas C; Elliott, Jeannette; Weikert, Madeline; Dlugonski, Deirdre; Sosnoff, Jacob J

2012-03-01

The disabling consequences of multiple sclerosis (MS) emphasize the significance of developing physiologically relevant strategies for rehabilitation of function. This pilot study examined changes in walking function associated with combined exercise training consisting of aerobic, resistance, and balance activities in persons with MS who had recent onset of gait impairment. Thirteen participants with significant disability due to MS (Expanded Disability Status Scale range = 4.0-6.0) completed the Multiple Sclerosis Walking Scale-12, 2 trials of the Timed 25-Foot Walk, the Timed Up & Go, and functional ambulation profile score derived from 4 walking trials on an instrumented walkway (GaitRite) before and after an 8-week training period. The training program was designed by a physical therapist and was performed 3 days per week under the supervision of an exercise specialist. In week 1, the session was 15 minutes in duration (ie, 5 minutes of each mode of exercise), session durations were increased by approximately 5 minutes per week up to a maximum of 60 minutes in week 8 (ie, 20 minutes of each mode of exercise). There were significant improvements in Multiple Sclerosis Walking Scale-12 scores (Mpre = 56.0, Mpost = 46.7, P = 0.03, d = 0.56), Timed 25-Foot Walk (Mpre = 11.7, Mpost = 9.8, P = 0.004, d = 0.90) and Timed Up & Go (Mpre = 16.0, Mpost = 13.0, P = 0.01, d = 0.72) performance, and functional ambulation profile score (Mpre = 72.8, Mpost = 77.6, P = 0.02, d = 0.65). These results suggest that a moderately intense, comprehensive, combined exercise training program represents a rehabilitation strategy that is associated with improved walking mobility in a small sample of persons with MS who have recent onset of gait impairment.

Image processing improvement for optical observations of space debris with the TAROT telescopes

NASA Astrophysics Data System (ADS)

Thiebaut, C.; Theron, S.; Richard, P.; Blanchet, G.; Klotz, A.; Boër, M.

2016-07-01

CNES is involved in the Inter-Agency Space Debris Coordination Committee (IADC) and is observing space debris with two robotic ground based fully automated telescopes called TAROT and operated by the CNRS. An image processing algorithm devoted to debris detection in geostationary orbit is implemented in the standard pipeline. Nevertheless, this algorithm is unable to deal with debris tracking mode images, this mode being the preferred one for debris detectability. We present an algorithm improvement for this mode and give results in terms of false detection rate.

Drought, Fire and Insects in Western US Forests: Observations to Improve Regional Land System Modeling

NASA Astrophysics Data System (ADS)

Law, B. E.; Yang, Z.; Berner, L. T.; Hicke, J. A.; Buotte, P.; Hudiburg, T. W.

2015-12-01

Drought, fire and insects are major disturbances in the western US, and conditions are expected to get warmer and drier in the future. We combine multi-scale observations and modeling with CLM4.5 to examine the effects of these disturbances on forests in the western US. We modified the Community Land Model, CLM4.5, to improve simulated drought-related mortality in forests, and prediction of insect outbreaks under future climate conditions. We examined differences in plant traits that represent species variation in sensitivity to drought, and redefined plant groupings in PFTs. Plant traits, including sapwood area: leaf area ratio and stemwood density were strongly correlated with water availability during the ecohydrologic year. Our database of co-located observations of traits for 30 tree species was used to produce parameterization of the model by species groupings according to similar traits. Burn area predicted by the new fire model in CLM4.5 compares well with recent years of GFED data, but has a positive bias compared with Landsat-based MTBS. Biomass mortality over recent decades increased, and was captured well by the model in general, but missed mortality trends of some species. Comparisons with AmeriFlux data showed that the model with dynamic tree mortality only (no species trait improvements) overestimated GPP in dry years compared with flux data at semi-arid sites, and underestimated GPP at more mesic sites that experience dry summers. Simulations with both dynamic tree mortality and species trait parameters improved estimates of GPP by 17-22%; differences between predicted and observed NEE were larger. Future projections show higher productivity from increased atmospheric CO2 and warming that somewhat offsets drought and fire effects over the next few decades. Challenges include representation of hydraulic failure in models, and availability of species trait and carbon/water process data in disturbance- and drought-impacted regions.

Increasing the statistical significance of entanglement detection in experiments.

PubMed

Jungnitsch, Bastian; Niekamp, Sönke; Kleinmann, Matthias; Gühne, Otfried; Lu, He; Gao, Wei-Bo; Chen, Yu-Ao; Chen, Zeng-Bing; Pan, Jian-Wei

2010-05-28

Entanglement is often verified by a violation of an inequality like a Bell inequality or an entanglement witness. Considerable effort has been devoted to the optimization of such inequalities in order to obtain a high violation. We demonstrate theoretically and experimentally that such an optimization does not necessarily lead to a better entanglement test, if the statistical error is taken into account. Theoretically, we show for different error models that reducing the violation of an inequality can improve the significance. Experimentally, we observe this phenomenon in a four-photon experiment, testing the Mermin and Ardehali inequality for different levels of noise. Furthermore, we provide a way to develop entanglement tests with high statistical significance.

Combination of blood tests for significant fibrosis and cirrhosis improves the assessment of liver-prognosis in chronic hepatitis C.

PubMed

Boursier, J; Brochard, C; Bertrais, S; Michalak, S; Gallois, Y; Fouchard-Hubert, I; Oberti, F; Rousselet, M-C; Calès, P

2014-07-01

Recent longitudinal studies have emphasised the prognostic value of noninvasive tests of liver fibrosis and cross-sectional studies have shown their combination significantly improves diagnostic accuracy. To compare the prognostic accuracy of six blood fibrosis tests and liver biopsy, and evaluate if test combination improves the liver-prognosis assessment in chronic hepatitis C (CHC). A total of 373 patients with compensated CHC, liver biopsy (Metavir F) and blood tests targeting fibrosis (APRI, FIB4, Fibrotest, Hepascore, FibroMeter) or cirrhosis (CirrhoMeter) were included. Significant liver-related events (SLRE) and liver-related deaths were recorded during follow-up (started the day of biopsy). During the median follow-up of 9.5 years (3508 person-years), 47 patients had a SLRE and 23 patients died from liver-related causes. For the prediction of first SLRE, most blood tests allowed higher prognostication than Metavir F [Harrell C-index: 0.811 (95% CI: 0.751-0.868)] with a significant increase for FIB4: 0.879 [0.832-0.919] (P = 0.002), FibroMeter: 0.870 [0.812-0.922] (P = 0.005) and APRI: 0.861 [0.813-0.902] (P = 0.039). Multivariate analysis identified FibroMeter, CirrhoMeter and sustained viral response as independent predictors of first SLRE. CirrhoMeter was the only independent predictor of liver-related death. The combination of FibroMeter and CirrhoMeter classifications into a new FM/CM classification improved the liver-prognosis assessment compared to Metavir F staging or single tests by identifying five subgroups of patients with significantly different prognoses. Some blood fibrosis tests are more accurate than liver biopsy for determining liver prognosis in CHC. A new combination of two complementary blood tests, one targeted for fibrosis and the other for cirrhosis, optimises assessment of liver-prognosis. © 2014 John Wiley & Sons Ltd.

An assessment of gravity model improvements using TOPEX/Poseidon TDRSS observations

NASA Technical Reports Server (NTRS)

Putney, B. H.; Teles, J.; Eddy, W. F.; Klosko, S. M.

1992-01-01

The contribution of TOPEX/Poseidon (T/P) TDRSS data to geopotential model recovery is assessed. Simulated TDRSS one-way and Bilateration Ranging Transponder System (BRTS) observations have been generated and orbitally reduced to form normal equations for geopotential parameters. These normals have been combined with those of the latest prelaunch T/P gravity model solution using data from over 30 satellites. A study of the resulting solution error covariance shows that TDRSS can make important contributions to geopotential recovery, especially for improving T/P specific effects like those arising from orbital resonance. It is argued that future effort is desirable both to establish TDRSS orbit determination limits in a reference frame compatible with that used for the precise laser/DORIS orbits, and the reduction of these TDRSS data for geopotential recovery.

A small electron donor in cobalt complex electrolyte significantly improves efficiency in dye-sensitized solar cells

PubMed Central

Hao, Yan; Yang, Wenxing; Zhang, Lei; Jiang, Roger; Mijangos, Edgar; Saygili, Yasemin; Hammarström, Leif; Hagfeldt, Anders; Boschloo, Gerrit

2016-01-01

Photoelectrochemical approach to solar energy conversion demands a kinetic optimization of various light-induced electron transfer processes. Of great importance are the redox mediator systems accomplishing the electron transfer processes at the semiconductor/electrolyte interface, therefore affecting profoundly the performance of various photoelectrochemical cells. Here, we develop a strategy—by addition of a small organic electron donor, tris(4-methoxyphenyl)amine, into state-of-art cobalt tris(bipyridine) redox electrolyte—to significantly improve the efficiency of dye-sensitized solar cells. The developed solar cells exhibit efficiency of 11.7 and 10.5%, at 0.46 and one-sun illumination, respectively, corresponding to a 26% efficiency improvement compared with the standard electrolyte. Preliminary stability tests showed the solar cell retained 90% of its initial efficiency after 250 h continuous one-sun light soaking. Detailed mechanistic studies reveal the crucial role of the electron transfer cascade processes within the new redox system. PMID:28000672

Assimilation of active and passive microwave observations for improved estimates of soil moisture and crop growth

USDA-ARS?s Scientific Manuscript database

An Ensemble Kalman Filter-based data assimilation framework that links a crop growth model with active and passive (AP) microwave models was developed to improve estimates of soil moisture (SM) and vegetation biomass over a growing season of soybean. Complementarities in AP observations were incorpo...

Hydrometeorology as an Inversion Problem: Can River Discharge Observations Improve the Atmosphere by Ensemble Data Assimilation?

NASA Astrophysics Data System (ADS)

Sawada, Yohei; Nakaegawa, Tosiyuki; Miyoshi, Takemasa

2018-01-01

We examine the potential of assimilating river discharge observations into the atmosphere by strongly coupled river-atmosphere ensemble data assimilation. The Japan Meteorological Agency's Non-Hydrostatic atmospheric Model (JMA-NHM) is first coupled with a simple rainfall-runoff model. Next, the local ensemble transform Kalman filter is used for this coupled model to assimilate the observations of the rainfall-runoff model variables into the JMA-NHM model variables. This system makes it possible to do hydrometeorology backward, i.e., to inversely estimate atmospheric conditions from the information of river flows or a flood on land surfaces. We perform a proof-of-concept Observing System Simulation Experiment, which reveals that the assimilation of river discharge observations into the atmospheric model variables can improve the skill of the short-term severe rainfall forecast.

Induction-heating MOCVD reactor with significantly improved heating efficiency and reduced harmful magnetic coupling

NASA Astrophysics Data System (ADS)

Li, Kuang-Hui; Alotaibi, Hamad S.; Sun, Haiding; Lin, Ronghui; Guo, Wenzhe; Torres-Castanedo, Carlos G.; Liu, Kaikai; Valdes-Galán, Sergio; Li, Xiaohang

2018-04-01

In a conventional induction-heating III-nitride metalorganic chemical vapor deposition (MOCVD) reactor, the induction coil is outside the chamber. Therefore, the magnetic field does not couple with the susceptor well, leading to compromised heating efficiency and harmful coupling with the gas inlet and thus possible overheating. Hence, the gas inlet has to be at a minimum distance away from the susceptor. Because of the elongated flow path, premature reactions can be more severe, particularly between Al- and B-containing precursors and NH3. Here, we propose a structure that can significantly improve the heating efficiency and allow the gas inlet to be closer to the susceptor. Specifically, the induction coil is designed to surround the vertical cylinder of a T-shaped susceptor comprising the cylinder and a top horizontal plate holding the wafer substrate within the reactor. Therefore, the cylinder coupled most magnetic field to serve as the thermal source for the plate. Furthermore, the plate can block and thus significantly reduce the uncoupled magnetic field above the susceptor, thereby allowing the gas inlet to be closer. The results show approximately 140% and 2.6 times increase in the heating and susceptor coupling efficiencies, respectively, as well as a 90% reduction in the harmful magnetic flux on the gas inlet.

Improving correlations between MODIS aerosol optical thickness and ground-based PM 2.5 observations through 3D spatial analyses

NASA Astrophysics Data System (ADS)

Hutchison, Keith D.; Faruqui, Shazia J.; Smith, Solar

The Center for Space Research (CSR) continues to focus on developing methods to improve correlations between satellite-based aerosol optical thickness (AOT) values and ground-based, air pollution observations made at continuous ambient monitoring sites (CAMS) operated by the Texas commission on environmental quality (TCEQ). Strong correlations and improved understanding of the relationships between satellite and ground observations are needed to formulate reliable real-time predictions of air quality using data accessed from the moderate resolution imaging spectroradiometer (MODIS) at the CSR direct-broadcast ground station. In this paper, improvements in these correlations are demonstrated first as a result of the evolution in the MODIS retrieval algorithms. Further improvement is then shown using procedures that compensate for differences in horizontal spatial scales between the nominal 10-km MODIS AOT products and CAMS point measurements. Finally, airborne light detection and ranging (lidar) observations, collected during the Texas Air Quality Study of 2000, are used to examine aerosol profile concentrations, which may vary greatly between aerosol classes as a result of the sources, chemical composition, and meteorological conditions that govern transport processes. Further improvement in correlations is demonstrated with this limited dataset using insights into aerosol profile information inferred from the vertical motion vectors in a trajectory-based forecast model. Analyses are ongoing to verify these procedures on a variety of aerosol classes using data collected by the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite (Calipso) lidar.

The Sensitivity of Adolescent Hearing Screens Significantly Improves by Adding High Frequencies.

PubMed

Sekhar, Deepa L; Zalewski, Thomas R; Beiler, Jessica S; Czarnecki, Beth; Barr, Ashley L; King, Tonya S; Paul, Ian M

2016-09-01

One in 6 US adolescents has high-frequency hearing loss, often related to hazardous noise. Yet, the American Academy of Pediatrics (AAP) hearing screen (500, 1,000, 2,000, 4,000 Hertz) primarily includes low frequencies (<3,000 Hertz). Study objectives were to determine (1) sensitivity and specificity of the AAP hearing screen for adolescent hearing loss and (2) if adding high frequencies increases sensitivity, while repeat screening of initial referrals reduces false positive results (maintaining acceptable specificity). Eleventh graders (n = 134) participated in hearing screening (2013-2014) including "gold-standard" sound-treated booth testing to calculate sensitivity and specificity. Of the 43 referrals, 27 (63%) had high-frequency hearing loss. AAP screen sensitivity and specificity were 58.1% (95% confidence interval 42.1%-73.0%) and 91.2% (95% confidence interval 83.4-96.1), respectively. Adding high frequencies (6,000, 8,000 Hertz) significantly increased sensitivity to 79.1% (64.0%-90.0%; p = .003). Specificity with repeat screening was 81.3% (71.8%-88.7%; p = .003). Adolescent hearing screen sensitivity improves with high frequencies. Repeat testing maintains acceptable specificity. Copyright © 2016 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

Experiments for improved positioning by means of integrated Doppler satellite observations and the NNSS broadcast ephemeris

NASA Technical Reports Server (NTRS)

Arur, M. G.

1977-01-01

An effort to improve station position recovery using broadcast ephemeris in Doppler data reduction was studied. A comparison of precise and broadcast ephemerides, treating the former as the standard, yielded information about the state disturbance that can be associated with the broadcast ephemeris. Statistical information about the state disturbance was used with current observational data for improved position recovery. The rank deficiency problem encountered in the short arc geodetic adjustment procedure was analysed and it was deduced that the fundamental rank deficiency is six, scale information being derivable from the wavelength of transmission. Coordinate differences between stations coobserving a pass are estimable. The uncertainty of the broadcast ephemeris, now in the WGS72 system, was assessed. It was conservatively estimated that its positional uncertainty may vary between 19 to 26 m in-track, 15 to 20 m cross-track and 9 to 10 m in radial directions depending on the incidence of the epoch of observations in the interinjection period.

Intensive precipitation observation greatly improves hydrological modelling of the poorly gauged high mountain Mabengnong catchment in the Tibetan Plateau

NASA Astrophysics Data System (ADS)

Wang, Li; Zhang, Fan; Zhang, Hongbo; Scott, Christopher A.; Zeng, Chen; Shi, Xiaonan

2018-01-01

Precipitation is one of the most critical inputs for models used to improve understanding of hydrological processes. In high mountain areas, it is challenging to generate a reliable precipitation data set capturing the spatial and temporal heterogeneity due to the harsh climate, extreme terrain and the lack of observations. This study conducts intensive observation of precipitation in the Mabengnong catchment in the southeast of the Tibetan Plateau during July to August 2013. Because precipitation is greatly influenced by altitude, the observed data are used to characterize the precipitation gradient (PG) and hourly distribution (HD), showing that the average PG is 0.10, 0.28 and 0.26 mm/d/100 m and the average duration is around 0.1, 0.8 and 5.2 h for trace, light and moderate rain, respectively. A distributed biosphere hydrological model based on water and energy budgets with improved physical process for snow (WEB-DHM-S) is applied to simulate the hydrological processes with gridded precipitation data derived from a lower altitude meteorological station and the PG and HD characterized for the study area. The observed runoff, MODIS/Terra snow cover area (SCA) data, and MODIS/Terra land surface temperature (LST) data are used for model calibration and validation. Runoff, SCA and LST simulations all show reasonable results. Sensitivity analyses illustrate that runoff is largely underestimated without considering PG, indicating that short-term intensive precipitation observation has the potential to greatly improve hydrological modelling of poorly gauged high mountain catchments.

Monitoring universal protocol compliance through real-time clandestine observation by medical students results in performance improvement.

PubMed

Logan, Catherine A; Cressey, Brienne D; Wu, Roger Y; Janicki, Adam J; Chen, Cyril X; Bolourchi, Meena L; Hodnett, Jessica L; Stratigis, John D; Mackey, William C; Fairchild, David G

2012-01-01

To measure universal protocol compliance through real-time, clandestine observation by medical students compared with chart audit reviews, and to enable medical students the opportunity to become conscious of the importance of medical errors and safety initiatives. With endorsement from Tufts Medical Center's (TMC's) Chief Medical Officer and Surgeon-in-Chief, 8 medical students performed clandestine observation audits of 98 cases from April to August 2009. A compliance checklist was based on TMC's presurgical checklist. Our initial results led to interventions to improve our universal protocol procedures, including modifications to the operating room white board and presurgical checklist, and specific feedback to surgical departments. One year later, 6 medical students performed observations of 100 cases from June to August 2010. Tufts Medical Center, Boston, Massachusetts, which is an academic medical center and the principal teaching hospital for Tufts University School of Medicine. An operating room coordinator placed the medical students into 1 of our 25 operating rooms with students entering under the premise of observing the anesthesiologist for clinical education. The observations were performed Monday to Friday between 7 am and 4 pm. Although observations were not randomized, no single service or type of surgery was targeted for observation. A broad range of departments was observed. In 8.2% of cases, the surgical site was unmarked. A Time Out occurred in 89.7% of cases. The entire surgical team was attentive during the time out in 82% of cases. The presurgical checklist was incomplete before incision in 13 cases. Images were displayed in 82% of cases. The operating room "white board" was filled out completely in 49% of cases. Team introductions occurred in 13 cases. One year later, compliance increased in all Universal Protocol dimensions. Direct, real-time observation by medical students provides an accurate and granular assessment of compliance with

Improving Earth/Prediction Models to Improve Network Processing

NASA Astrophysics Data System (ADS)

Wagner, G. S.

2017-12-01

The United States Atomic Energy Detection System (USAEDS) primaryseismic network consists of a relatively small number of arrays andthree-component stations. The relatively small number of stationsin the USAEDS primary network make it both necessary and feasibleto optimize both station and network processing.Station processing improvements include detector tuning effortsthat use Receiver Operator Characteristic (ROC) curves to helpjudiciously set acceptable Type 1 (false) vs. Type 2 (miss) errorrates. Other station processing improvements include the use ofempirical/historical observations and continuous background noisemeasurements to compute time-varying, maximum likelihood probabilityof detection thresholds.The USAEDS network processing software makes extensive use of theazimuth and slowness information provided by frequency-wavenumberanalysis at array sites, and polarization analysis at three-componentsites. Most of the improvements in USAEDS network processing aredue to improvements in the models used to predict azimuth, slowness,and probability of detection. Kriged travel-time, azimuth andslowness corrections-and associated uncertainties-are computedusing a ground truth database. Improvements in station processingand the use of improved models for azimuth, slowness, and probabilityof detection have led to significant improvements in USADES networkprocessing.

Prostate health index (phi) and prostate cancer antigen 3 (PCA3) significantly improve diagnostic accuracy in patients undergoing prostate biopsy.

PubMed

Perdonà, Sisto; Bruzzese, Dario; Ferro, Matteo; Autorino, Riccardo; Marino, Ada; Mazzarella, Claudia; Perruolo, Giuseppe; Longo, Michele; Spinelli, Rosa; Di Lorenzo, Giuseppe; Oliva, Andrea; De Sio, Marco; Damiano, Rocco; Altieri, Vincenzo; Terracciano, Daniela

2013-02-15

Prostate health index (phi) and prostate cancer antigen 3 (PCA3) have been recently proposed as novel biomarkers for prostate cancer (PCa). We assessed the diagnostic performance of these biomarkers, alone or in combination, in men undergoing first prostate biopsy for suspicion of PCa. One hundred sixty male subjects were enrolled in this prospective observational study. PSA molecular forms, phi index (Beckman coulter immunoassay), PCA3 score (Progensa PCA3 assay), and other established biomarkers (tPSA, fPSA, and %fPSA) were assessed before patients underwent a 18-core first prostate biopsy. The discriminating ability between PCa-negative and PCa-positive biopsies of Beckman coulter phi and PCA3 score and other used biomarkers were determined. One hundred sixty patients met inclusion criteria. %p2PSA (p2PSA/fPSA × 100), phi and PCA3 were significantly higher in patients with PCa compared to PCa-negative group (median values: 1.92 vs. 1.55, 49.97 vs. 36.84, and 50 vs. 32, respectively, P ≤ 0.001). ROC curve analysis showed that %p2PSA, phi, and PCA3 are good indicator of malignancy (AUCs = 0.68, 0.71, and 0.66, respectively). A multivariable logistic regression model consisting of both the phi index and PCA3 score allowed to reach an overall diagnostic accuracy of 0.77. Decision curve analysis revealed that this "combined" marker achieved the highest net benefit over the examined range of the threshold probability. phi and PCA3 showed no significant difference in the ability to predict PCa diagnosis in men undergoing first prostate biopsy. However, diagnostic performance is significantly improved by combining phi and PCA3. Copyright © 2012 Wiley Periodicals, Inc.

Improving oceanographic data delivery through pipeline processing in a Commercial Cloud Services environment: the Australian Integrated Marine Observing System

NASA Astrophysics Data System (ADS)

Besnard, Laurent; Blain, Peter; Mancini, Sebastien; Proctor, Roger

2017-04-01

The Integrated Marine Observing System (IMOS) is a national project funded by the Australian government established to deliver ocean observations to the marine and climate science community. Now in its 10th year its mission is to undertake systematic and sustained observations and to turn them into data, products and analyses that can be freely used and reused for broad societal benefits. As IMOS has matured as an observing system expectation on the system's availability and reliability has also increased and IMOS is now seen as delivering 'operational' information. In responding to this expectation, IMOS has relocated its services to the commercial cloud service Amazon Web Services. This has enabled IMOS to improve the system architecture, utilizing more advanced features like object storage (S3 - Simple Storage Service) and autoscaling features, and introducing new checking procedures in a pipeline approach. This has improved data availability and resilience while protecting against human errors in data handling and providing a more efficient ingestion process.

Bone Mass and Strength are Significantly Improved in Mice Overexpressing Human WNT16 in Osteocytes.

PubMed

Alam, Imranul; Reilly, Austin M; Alkhouli, Mohammed; Gerard-O'Riley, Rita L; Kasipathi, Charishma; Oakes, Dana K; Wright, Weston B; Acton, Dena; McQueen, Amie K; Patel, Bhavmik; Lim, Kyung-Eun; Robling, Alexander G; Econs, Michael J

2017-04-01

Recently, we demonstrated that osteoblast-specific overexpression of human WNT16 increased both cortical and trabecular bone mass and structure in mice. To further identify the cell-specific role of Wnt16 in bone homeostasis, we created transgenic (TG) mice overexpressing human WNT16 in osteocytes using Dmp1 promoter (Dmp1-hWNT16 TG) on C57BL/6 (B6) background. We analyzed bone phenotypes and serum bone biomarkers, performed gene expression analysis and measured dynamic bone histomorphometry in Dmp1-hWNT16 TG and wild-type (WT) mice. Compared to WT mice, Dmp1-hWNT16 TG mice exhibited significantly higher whole-body, spine and femoral aBMD, BMC and trabecular (BV/TV, Tb.N, and Tb.Th) and cortical (bone area and thickness) parameters in both male and female at 12 weeks of age. Femur stiffness and ultimate force were also significantly improved in the Dmp1-hWNT16 TG female mice, compared to sex-matched WT littermates. In addition, female Dmp1-hWNT16 TG mice displayed significantly higher MS/BS, MAR and BFR/BS compared to the WT mice. Gene expression analysis demonstrated significantly higher mRNA level of Alp in both male and female Dmp1-hWNT16 TG mice and significantly higher levels of Osteocalcin, Opg and Rankl in the male Dmp1-hWNT16 TG mice in bone tissue compared to sex-matched WT mice. These results indicate that WNT16 plays a critical role for acquisition of both cortical and trabecular bone mass and strength. Strategies designed to use WNT16 as a target for therapeutic interventions will be valuable to treat osteoporosis and other low bone mass conditions.

Bone Mass and Strength are Significantly Improved in Mice Overexpressing Human WNT16 in Osteocytes

PubMed Central

Alam, Imranul; Reilly, Austin M.; Alkhouli, Mohammed; Gerard-O’Riley, Rita L.; Kasipathi, Charishma; Oakes, Dana K.; Wright, Weston B.; Acton, Dena; McQueen, Amie K.; Patel, Bhavmik; Lim, Kyung-Eun; Robling, Alexander G.; Econs, Michael J.

2017-01-01

Recently, we demonstrated that osteoblast-specific overexpression of human WNT16 increased both cortical and trabecular bone mass and structure in mice. To further identify the cell-specific role of Wnt16 in bone homeostasis, we created transgenic (TG) mice over-expressing human WNT16 in osteocytes using Dmp1 promoter (Dmp1-hWNT16 TG) on C57BL/6 (B6) background. We analyzed bone phenotypes and serum bone biomarkers, performed gene expression analysis and measured dynamic bone histomorphometry in Dmp1-hWNT16 TG and wild-type (WT) mice. Compared to WT mice, Dmp1-hWNT16 TG mice exhibited significantly higher whole body, spine and femoral aBMD, BMC and trabecular (BV/TV, Tb.N, and Tb.Th) and cortical (bone area and thickness) parameters in both male and female at 12 weeks of age. Femur stiffness and ultimate force were also significantly improved in the Dmp1-hWNT16 TG female mice, compared to sex-matched WT littermates. In addition, female Dmp1-hWNT16 TG mice displayed significantly higher MS/BS, MAR and BFR/BS compared to the WT mice. Gene expression analysis demonstrated significantly higher mRNA level of Alp in both male and female Dmp1-hWNT16 TG mice and significantly higher levels of Osteocalcin, Opg and Rankl in the male Dmp1-hWNT16 TG mice in bone tissue compared to sex-matched WT mice. These results indicate that WNT16 plays a critical role for acquisition of both cortical and trabecular bone mass and strength. Strategies designed to use WNT16 as a target for therapeutic interventions will be valuable to treat osteoporosis and other low bone mass conditions. PMID:28013361

A progressive 5-week exercise therapy program leads to significant improvement in knee function early after anterior cruciate ligament injury.

PubMed

Eitzen, Ingrid; Moksnes, Håvard; Snyder-Mackler, Lynn; Risberg, May Arna

2010-11-01

Prospective cohort study without a control group. Firstly, to present our 5-week progressive exercise therapy program in the early stage after anterior cruciate ligament (ACL) injury. Secondly, to evaluate changes in knee function after completion of the program for patients with ACL injury in general and also when classified as potential copers or noncopers, and, finally, to examine potential adverse events. Few studies concerning early-stage ACL rehabilitation protocols exist. Consequently, little is known about the tolerance for, and outcomes from, short-term exercise therapy programs in the early stage after injury. One-hundred patients were included in a 5-week progressive exercise therapy program, within 3 months after injury. Knee function before and after completion of the program was evaluated from isokinetic quadriceps and hamstrings muscle strength tests, 4 single-leg hop tests, 2 different self-assessment questionnaires, and a global rating of knee function. A 2-way mixed-model analysis of variance was conducted to evaluate changes from pretest to posttest for the limb symmetry index for muscle strength and single-leg hop tests, and the change in scores for the patient-reported questionnaires. In addition, absolute values and the standardized response mean for muscle strength and single-leg hop tests were calculated at pretest and posttest for the injured and uninjured limb. Adverse events during the 5-week period were recorded. The progressive 5-week exercise therapy program led to significant improvements (P<.05) in knee function from pretest to posttest both for patients classified as potential copers and noncopers. Standardized response mean values for changes in muscle strength and single-leg hop performance from pretest to posttest for the injured limb were moderate to strong (0.49-0.84), indicating the observed improvements to be clinically relevant. Adverse events occurred in 3.9% of the patients. Short-term progressive exercise therapy programs

AIRS associated accomplishments at the JCSDA: First use of full spatial resolution hyperspectral data show significant improvements in global forecasts

NASA Astrophysics Data System (ADS)

Le Marshall, J.; Jung, J.; Lord, S. J.; Derber, J. C.; Treadon, R.; Joiner, J.; Goldberg, M.; Wolf, W.; Liu, H. C.

2005-08-01

The National Aeronautics and Space Administration (NASA), National Oceanic and Atmospheric Administration (NOAA), and Department of Defense (DoD), Joint Center for Satellite Data Assimilation (JCSDA) was established in 2000/2001. The goal of the JCSDA is to accelerate the use of observations from earth-orbiting satellites into operational numerical environmental analysis and prediction systems for the purpose of improving weather and oceanic forecasts, seasonal climate forecasts and the accuracy of climate data sets. As a result, a series of data assimilation experiments were undertaken at the JCSDA as part of the preparations for the operational assimilation of AIRS data by its partner organizations1,2. Here, for the first time full spatial resolution radiance data, available in real-time from the AIRS instrument, were used at the JCSDA in data assimilation studies over the globe utilizing the operational NCEP Global Forecast System (GFS). The radiance data from each channel of the instrument were carefully screened for cloud effects and those radiances which were deemed to be clear of cloud effects were used by the GFS forecast system. The result of these assimilation trials has been a first demonstration of significant improvements in forecast skill over both the Northern and Southern Hemisphere compared to the operational system without AIRS data. The experimental system was designed in a way that rendered it feasible for operational application, and that constraint involved using the subset of AIRS channels chosen for operational distribution and an analysis methodology close to the current analysis practice, with particular consideration given to time limitations. As a result, operational application of these AIRS data was enabled by the recent NCEP operational upgrade. In addition, because of the improved impact resulting from use of this enhanced data set compared to that used operationally to date, provision of a realtime "warmest field" of view data set

Improvement in the observation system for the GPS/A seafloor positioning

NASA Astrophysics Data System (ADS)

Fujimoto, H.; Kido, M.; Osada, Y.

2010-12-01

GPS/Acoustic seafloor positioning has become an indispensable geodetic observation for the monitoring of crustal activities near plate boundaries. There remain, however, substantial differences from GPS observation on land. Our group in Tohoku University has been working to cope with the problems under the program of the DONET, JAMSTEC.One of critical problems regarding the present GPS/A observation lies in the campaign style observation spending one or two days to measure the position of an array of acoustic transponders (PXPs) once or twice a year. It is similar to the triangulation observation on land before the age of the GPS. Chadwell et al. (2009, AGU Fall Meeting) made a step forward for this problem by carrying out a continuous GPS/A observation with a moored buoy. We are also developing a system using a moored small buoy. Precision of seafloor positioning by GPS/A is another critical problems. Considering that plate motions are several centimeters per year in most cases, precision of a few centimeters by GPS/A is a big difference from a few millimeters by GPS on land. We estimate that lateral variations in the sound velocity in the ocean can be a key to improve the precision in the positioning and to reduce the required time for the measurement, we have tried to estimate the lateral variations in the acoustic velocity by using 4-5 PXPs (Kido et al., 2006; Kido et al., this meeting). Long-term attitude stability of the position of a PXP deployed on thick sediment has been a basic problem in the GPS/A observation. While a pillar of a GPS antenna for an observation point is set up firmly on the ground, a PXP is deployed on the seafloor after a free fall from the sea surface. It is a serious problem to detect coseismic crustal movements on the seafloor. M7-class earthquakes occurred in 2004 off Kii Peninsula, Central Japan, gave us an opportunity to study the problem. By using an ROV (remotely operated vehicle), we visually observed ten PXPs in 2006, seven of

The role of observational research in improving faculty lecturing skills: A qualitative study in an Italian dental school.

PubMed

Visioli, Sonia; Lodi, Giovanni; Carrassi, Antonio; Zannini, Lucia

2009-08-01

This pilot study is based on observational research of lecturing skills during the annual Oral Medicine course at the Milan Dentistry School. Our goals were to explore how teachers exhibited desirable lecturing skills, to observe how their attitudes and lecturing skills affected students' attention and thereby learning, and to provide feedback. We prepared a structured observational grid divided into four categories: explaining, questioning, visual aids, and lecturer attitude. The grid was filled in by a participant, nonactive researcher. Two main types of lecture were observed: "traditional" and "interactive". Both of these can result in a high level of attention among students. Among the categories, only "lecturer attitude" appeared to affect student attention. In particular, the skills of "speaking aloud" and "sustaining verbal communication with vocal inflection" appeared to have the greatest impact on lecturer attitude. The data were then presented blindly to the five lecturers, who were able to identify their own lesson. Our grid proved to be a valid instrument although it was very expensive. When integrated with other strategies for improving lecturing, such as student scoring, peer evaluation, and microteaching, observational research can be a cost-effective method to stimulate guided reflection and to improve the lecturing skills of faculty members.

Can we use Earth Observations to improve monthly water level forecasts?

NASA Astrophysics Data System (ADS)

Slater, L. J.; Villarini, G.

2017-12-01

Dynamical-statistical hydrologic forecasting approaches benefit from different strengths in comparison with traditional hydrologic forecasting systems: they are computationally efficient, can integrate and `learn' from a broad selection of input data (e.g., General Circulation Model (GCM) forecasts, Earth Observation time series, teleconnection patterns), and can take advantage of recent progress in machine learning (e.g. multi-model blending, post-processing and ensembling techniques). Recent efforts to develop a dynamical-statistical ensemble approach for forecasting seasonal streamflow using both GCM forecasts and changing land cover have shown promising results over the U.S. Midwest. Here, we use climate forecasts from several GCMs of the North American Multi Model Ensemble (NMME) alongside 15-minute stage time series from the National River Flow Archive (NRFA) and land cover classes extracted from the European Space Agency's Climate Change Initiative 300 m annual Global Land Cover time series. With these data, we conduct systematic long-range probabilistic forecasting of monthly water levels in UK catchments over timescales ranging from one to twelve months ahead. We evaluate the improvement in model fit and model forecasting skill that comes from using land cover classes as predictors in the models. This work opens up new possibilities for combining Earth Observation time series with GCM forecasts to predict a variety of hazards from space using data science techniques.

The Group on Earth Observations and the Global Earth Observation System of Systems

NASA Astrophysics Data System (ADS)

Achache, J.

2006-05-01

The Group on Earth Observations (GEO) is leading a worldwide effort to build a Global Earth Observation System of Systems (GEOSS) over the next 10 years. The GEOSS vision, articulated in its 10-Year Implementation Plan, represents the consolidation of a global scientific and political consensus: the assessment of the state of the Earth requires continuous and coordinated observation of our planet at all scales. GEOSS aims to achieve comprehensive, coordinated and sustained observations of the Earth system in order to improve monitoring of the state of the Earth; increase understanding of Earth processes; and enhance prediction of the behaviour of the Earth system. After the World Summit on Sustainable Development in 2002 highlighted the urgent need for coordinated observations relating to the state of the Earth, GEO was established at the Third Earth Observation Summit in February 2005 and the GEOSS 10-Year Implementation Plan was endorsed. GEO currently involves 60 countries; the European Commission; and 43 international organizations and has begun implementation of the GEOSS 10-Year Implementation Plan. GEO programme activities cover nine societal benefit areas (Disasters; Health; Energy; Climate; Water; Weather; Ecosystems; Agriculture; Biodiversity) and five transverse or crosscutting elements (User Engagement; Architecture; Data Management; Capacity Building; Outreach). All these activities have as their final goal the establishment of the "system of systems" which will yield a broad range of basic societal benefits, including the reduction of loss of life and property from tsunamis, hurricanes, and other natural disasters; improved water resource and energy management; and improved understanding of environmental factors significant to public health. As a "system of systems", GEOSS will work with and build upon existing national, regional, and international systems to provide comprehensive, coordinated Earth observations from thousands of instruments worldwide

Can mobile technology improve response times of junior doctors to urgent out-of-hours calls? A prospective observational study.

PubMed

Herrod, P J J; Barclay, C; Blakey, J D

2014-04-01

The Hospital at Night system has been widely adopted to manage Out-of-Hours workload. However, it has the potential to introduce delays and corruption of information. The introduction of newer technologies to replace landlines, pagers and paper may ameliorate these issues. To establish if the introduction of a Hospital at Night system supported by a wireless taskflow system affected the escalation of high Early Warning Scores (EWSs) to medical attention, and the time taken to medical review. Prospective 'pre and post' observational study in a teaching hospital in the UK. Review of observation charts and medical records, and data extraction from the electronic taskflow system. The implementation of a technology-supported Hospital at Night system was associated with a significant decrease in time to documentation of initial review in those who were reviewed. However, there was no change in the proportion of those with a high EWS that were reviewed, and throughout the study a majority of patients with high EWSs were not reviewed in accordance with guidelines. Introduction of a Hospital at Night system supported by mobile technology appeared to improve the transfer of information, but did not affect the nursing decision whether to escalate abnormal findings.

Cyclosporin A significantly improves preeclampsia signs and suppresses inflammation in a rat model.

PubMed

Hu, Bihui; Yang, Jinying; Huang, Qian; Bao, Junjie; Brennecke, Shaun Patrick; Liu, Huishu

2016-05-01

Preeclampsia is associated with an increased inflammatory response. Immune suppression might be an effective treatment. The aim of this study was to examine whether Cyclosporin A (CsA), an immunosuppressant, improves clinical characteristics of preeclampsia and suppresses inflammation in a lipopolysaccharide (LPS) induced preeclampsia rat model. Pregnant rats were randomly divided into 4 groups: group 1 (PE) rats each received LPS via tail vein on gestational day (GD) 14; group 2 (PE+CsA5) rats were pretreated with LPS (1.0 μg/kg) on GD 14 and were then treated with CsA (5mg/kg, ip) on GDs 16, 17 and 18; group 3 (PE+CsA10) rats were pretreated with LPS (1.0 μg/kg) on GD 14 and were then treated with CsA (10mg/kg, ip) on GDs 16, 17 and 18; group 4 (pregnant control, PC) rats were treated with the vehicle (saline) used for groups 1, 2 and 3. Systolic blood pressure, urinary albumin, biometric parameters and the levels of serum cytokines were measured on day 20. CsA treatment significantly reduced LPS-induced systolic blood pressure and the mean 24-h urinary albumin excretion. Pro-inflammatory cytokines IL-6, IL-17, IFN-γ and TNF-α were increased in the LPS treatment group but were reduced in (LPS+CsA) group (P<0.05). Anti-inflammatory cytokine IL-4 was decreased in the LPS group but was increased in (LPS+CsA) group (P<0.05). Cyclosporine A improved preeclampsia signs and attenuated inflammatory responses in the LPS induced preeclampsia rat model which suggests that immunosuppressant might be an alternative management option for preeclampsia. Copyright © 2016 Elsevier Ltd. All rights reserved.

Steam cooking significantly improves in vitro bile acid binding of collard greens, kale, mustard greens, broccoli, green bell pepper, and cabbage.

PubMed

Kahlon, Talwinder Singh; Chiu, Mei-Chen M; Chapman, Mary H

2008-06-01

Bile acid binding capacity has been related to the cholesterol-lowering potential of foods and food fractions. Lowered recirculation of bile acids results in utilization of cholesterol to synthesize bile acid and reduced fat absorption. Secondary bile acids have been associated with increased risk of cancer. Bile acid binding potential has been related to lowering the risk of heart disease and that of cancer. Previously, we have reported bile acid binding by several uncooked vegetables. However, most vegetables are consumed after cooking. How cooking would influence in vitro bile acid binding of various vegetables was investigated using a mixture of bile acids secreted in human bile under physiological conditions. Eight replicate incubations were conducted for each treatment simulating gastric and intestinal digestion, which included a substrate only, a bile acid mixture only, and 6 with substrate and bile acid mixture. Cholestyramine (a cholesterol-lowering, bile acid binding drug) was the positive control treatment and cellulose was the negative control. Relative to cholestyramine, in vitro bile acid binding on dry matter basis was for the collard greens, kale, and mustard greens, 13%; broccoli, 10%; Brussels sprouts and spinach, 8%; green bell pepper, 7%; and cabbage, 5%. These results point to the significantly different (P < or = .05) health-promoting potential of collard greens = kale = mustard greens > broccoli > Brussels sprouts = spinach = green bell pepper > cabbage as indicated by their bile acid binding on dry matter basis. Steam cooking significantly improved the in vitro bile acid binding of collard greens, kale, mustard greens, broccoli, green bell pepper, and cabbage compared with previously observed bile acid binding values for these vegetables raw (uncooked). Inclusion of steam-cooked collard greens, kale, mustard greens, broccoli, green bell pepper, and cabbage in our daily diet as health-promoting vegetables should be emphasized. These green

Improving Soil Moisture Estimation through the Joint Assimilation of SMOS and GRACE Satellite Observations

NASA Technical Reports Server (NTRS)

Girotto, Manuela

2018-01-01

Observations from recent soil moisture dedicated missions (e.g. SMOS or SMAP) have been used in innovative data assimilation studies to provide global high spatial (i.e., approximately10-40 km) and temporal resolution (i.e., daily) soil moisture profile estimates from microwave brightness temperature observations. These missions are only sensitive to near-surface soil moisture 0-5 cm). In contrast, the Gravity Recovery and Climate Experiment (GRACE) mission provides accurate measurements of the entire vertically integrated terrestrial water storage (TWS) column but, it is characterized by low spatial (i.e., 150,000 km2) and temporal (i.e., monthly) resolutions. Data assimilation studies have shown that GRACE-TWS primarily affects (in absolute terms) deeper moisture storages (i.e., groundwater). In this presentation I will review benefits and drawbacks associated to the assimilation of both types of observations. In particular, I will illustrate the benefits and drawbacks of their joint assimilation for the purpose of improving the entire profile of soil moisture (i.e., surface and deeper water storages).

Improvement of the ephemerides of Phoebe, 9th satellite of Saturn, from new observations made from 1995 to 2000

NASA Astrophysics Data System (ADS)

Arlot, J.-E.; Bec-Borsenberger, A.; Fienga, A.; Baron, N.

2003-11-01

In order to improve the model used for the ephemerides of Phoebe, the 9th satellite of Saturn, we started observations in 1998. We made 135 observations in 1998 and 39 observations in 1999 using the 120 cm-telescope of Observatoire de Haute-Provence, France. We used a numerical integration in order to calculate new initial conditions and to be able to build new ephemerides. We also used some precise observations made from 1995 to 2000 together with old observations for that purpose. The result is a decrease in the uncertainties on Phoebe's orbit. Based in part on observations made at observatoire de Haute Provence (CNRS), France.

Behavioral training to improve collision detection

PubMed Central

DeLoss, Denton J.; Bian, Zheng; Watanabe, Takeo; Andersen, George J.

2015-01-01

Young drivers are a high-risk group for vehicle crashes due to inexperience in detecting an impending collision and are one group that may benefit from perceptual learning (PL) training. The present study assessed whether PL could be used to improve performance in collision detection. Ten college-aged subjects participated in the first experiment, which consisted of seven 1-hr sessions conducted on separate days. Thresholds at three observer/object speeds were measured prior to training using a two-alternative forced choice procedure during which they indicated whether an approaching object would result in a collision or noncollision event. Participants were then trained near threshold at one of these speeds for 5 days. After training, participants showed a significant reduction in the time needed to detect a collision at the trained speed. This improvement was also found to transfer to the higher observer speed condition. A second experiment was conducted to determine whether this improvement was due to training near threshold or whether this improvement was merely due to practice with the task. Training with stimuli well above threshold showed no significant improvement in performance, indicating that the improvement seen in the first experiment was not solely due to task practice. PMID:26230917

Effects of self-esteem improvement program on self-esteem and peer attachment in elementary school children with observed problematic behaviors.

PubMed

Park, Kyung Min; Park, Heeok

2015-03-01

The purpose of this study was to investigate the effects of a self-esteem improvement program on self-esteem and peer attachment in elementary school children with observed problematic behaviors. This study is a quasi-experimental study with a nonequivalent control group pretest-post-test design. A total of 47 fourth grade elementary school students participated in this study. The program was provided for 45 minutes once a week; a total of 12 sessions were completed with a group in the classroom for the experimental group. Child Problem-Behavior Screening Questionnaire was used to measure problematic behavior. Self-esteem was measured using the Rosenberg's Self-esteem Questionnaire, and peer attachment was measured using the Inventory of Parent and Attachment. Measuring was performed right after the program was done (post 1) and 1 month after the program was finished (post 2). To compare the differences in self-esteem and peer attachment between groups, repeated measures analysis of variance was used. Most participants in the experimental group were 10 years old (62.5%, range 10-11), male (52.0%) and with middle grade point average (64.0%). The self-esteem scores in the experimental group were significantly higher than those of the control group (F = 26.64, p < .001). The peer attachment scores in the experimental group were significantly higher than those of the control group (F = 6.48, p = .014). The self-esteem improvement program in this study improved the self-esteem and peer attachment in elementary school children. The self-esteem program helped acknowledge the peer's name and increased their connections. The program needs to be considered as a formal and consistent program. Copyright © 2015. Published by Elsevier B.V.

The first international workshop on "Advancement of POLarimetric Observations: calibration and improved aerosol retrievals": APOLO-2017

NASA Astrophysics Data System (ADS)

Dubovik, Oleg; Li, Zhengqiang; Mishchenko, Michael I.

2018-06-01

The international workshop on "Advancement of POLarimetric Observations: calibration and improved aerosol retrievals-2017" (APOLO-2017) took place in Hefei, China on 24 - 27 October 2017. This was the inaugural meeting of a planned series of workshops on satellite polarimetry aimed at addressing the rapidly growing interest of the scientific community in polarimetric remote-sensing observations from space. The workshop was held at the Anhui Institute of Optics and Fine Mechanics, Hefei, widely known for 15 years of experience in the development of research polarimetry sensors and for hosting the building in parallel of several orbital polarimeters.

An improved method to set significance thresholds for β diversity testing in microbial community comparisons.

PubMed

Gülay, Arda; Smets, Barth F

2015-09-01

Exploring the variation in microbial community diversity between locations (β diversity) is a central topic in microbial ecology. Currently, there is no consensus on how to set the significance threshold for β diversity. Here, we describe and quantify the technical components of β diversity, including those associated with the process of subsampling. These components exist for any proposed β diversity measurement procedure. Further, we introduce a strategy to set significance thresholds for β diversity of any group of microbial samples using rarefaction, invoking the notion of a meta-community. The proposed technique was applied to several in silico generated operational taxonomic unit (OTU) libraries and experimental 16S rRNA pyrosequencing libraries. The latter represented microbial communities from different biological rapid sand filters at a full-scale waterworks. We observe that β diversity, after subsampling, is inflated by intra-sample differences; this inflation is avoided in the proposed method. In addition, microbial community evenness (Gini > 0.08) strongly affects all β diversity estimations due to bias associated with rarefaction. Where published methods to test β significance often fail, the proposed meta-community-based estimator is more successful at rejecting insignificant β diversity values. Applying our approach, we reveal the heterogeneous microbial structure of biological rapid sand filters both within and across filters. © 2014 Society for Applied Microbiology and John Wiley & Sons Ltd.

Blending forest fire smoke forecasts with observed data can improve their utility for public health applications

NASA Astrophysics Data System (ADS)

Yuchi, Weiran; Yao, Jiayun; McLean, Kathleen E.; Stull, Roland; Pavlovic, Radenko; Davignon, Didier; Moran, Michael D.; Henderson, Sarah B.

2016-11-01

Fine particulate matter (PM2.5) generated by forest fires has been associated with a wide range of adverse health outcomes, including exacerbation of respiratory diseases and increased risk of mortality. Due to the unpredictable nature of forest fires, it is challenging for public health authorities to reliably evaluate the magnitude and duration of potential exposures before they occur. Smoke forecasting tools are a promising development from the public health perspective, but their widespread adoption is limited by their inherent uncertainties. Observed measurements from air quality monitoring networks and remote sensing platforms are more reliable, but they are inherently retrospective. It would be ideal to reduce the uncertainty in smoke forecasts by integrating any available observations. This study takes spatially resolved PM2.5 estimates from an empirical model that integrates air quality measurements with satellite data, and averages them with PM2.5 predictions from two smoke forecasting systems. Two different indicators of population respiratory health are then used to evaluate whether the blending improved the utility of the smoke forecasts. Among a total of six models, including two single forecasts and four blended forecasts, the blended estimates always performed better than the forecast values alone. Integrating measured observations into smoke forecasts could improve public health preparedness for smoke events, which are becoming more frequent and intense as the climate changes.

Improved scores for observed teamwork in the clinical environment following a multidisciplinary operating room simulation intervention.

PubMed

Weller, Jennifer M; Cumin, David; Civil, Ian D; Torrie, Jane; Garden, Alexander; MacCormick, Andrew D; Gurusinghe, Nishanthi; Boyd, Matthew J; Frampton, Christopher; Cokorilo, Martina; Tranvik, Magnus; Carlsson, Lisa; Lee, Tracey; Ng, Wai Leap; Crossan, Michael; Merry, Alan F

2016-08-05

We ran a Multidisciplinary Operating Room Simulation (MORSim) course for 20 complete general surgical teams from two large metropolitan hospitals. Our goal was to improve teamwork and communication in the operating room (OR). We hypothesised that scores for teamwork and communication in the OR would improve back in the workplace following MORSim. We used an extended Behavioural Marker Risk Index (BMRI) to measure teamwork and communication, because a relationship has previously been documented between BMRI scores and surgical patient outcomes. Trained observers scored general surgical teams in the OR at the two study hospitals before and after MORSim, using the BMRI. Analysis of BMRI scores for the 224 general surgical cases before and 213 cases after MORSim showed BMRI scores improved by more than 20% (0.41 v 0.32, p<0.001). Previous research suggests that this improved teamwork score would translate into a clinically important reduction in complications and mortality in surgical patients. We demonstrated an improvement in scores for teamwork and communication in general surgical ORs following our intervention. These results support the use of simulation-based multidisciplinary team training for OR staff to promote better teamwork and communication, and potentially improve outcomes for general surgical patients.

Improving Growth and Productivity of Oleiferous Brassicas under Changing Environment: Significance of Nitrogen and Sulphur Nutrition, and Underlying Mechanisms

PubMed Central

Anjum, Naser A.; Gill, Sarvajeet S.; Umar, Shahid; Ahmad, Iqbal; Duarte, Armando C.; Pereira, Eduarda

2012-01-01

Mineral nutrients are the integral part of the agricultural systems. Among important plant nutrients, nitrogen (N) and sulphur (S) are known essential elements for growth, development, and various physiological functions in plants. Oleiferous brassicas (rapeseed and mustard) require higher amounts of S in addition to N for optimum growth and yield. Therefore, balancing S-N fertilization, optimization of nutrient replenishment, minimization of nutrient losses to the environment, and the concept of coordination in action between S and N could be a significant strategy for improvement of growth and productivity of oleiferous brassicas. Additionally, positive interaction between S and N has been reported to be beneficial for various aspects of oilseed brassicas. The current paper updates readers on the significance of N and S for the improvement of plant growth, development, and productivity in detail. In addition, S-N nutrition-mediated control of major plant antioxidant defense system components involved in the removal and/or metabolism of stress-induced/generated reactive oxygen species in plants (hence, the control of plant growth, development, and productivity) has been overviewed. PMID:22629181

Public-Private Partnership: Joint recommendations to improve downloads of large Earth observation data

NASA Astrophysics Data System (ADS)

Ramachandran, R.; Murphy, K. J.; Baynes, K.; Lynnes, C.

2016-12-01

With the volume of Earth observation data expanding rapidly, cloud computing is quickly changing the way Earth observation data is processed, analyzed, and visualized. The cloud infrastructure provides the flexibility to scale up to large volumes of data and handle high velocity data streams efficiently. Having freely available Earth observation data collocated on a cloud infrastructure creates opportunities for innovation and value-added data re-use in ways unforeseen by the original data provider. These innovations spur new industries and applications and spawn new scientific pathways that were previously limited due to data volume and computational infrastructure issues. NASA, in collaboration with Amazon, Google, and Microsoft, have jointly developed a set of recommendations to enable efficient transfer of Earth observation data from existing data systems to a cloud computing infrastructure. The purpose of these recommendations is to provide guidelines against which all data providers can evaluate existing data systems and be used to improve any issues uncovered to enable efficient search, access, and use of large volumes of data. Additionally, these guidelines ensure that all cloud providers utilize a common methodology for bulk-downloading data from data providers thus preventing the data providers from building custom capabilities to meet the needs of individual cloud providers. The intent is to share these recommendations with other Federal agencies and organizations that serve Earth observation to enable efficient search, access, and use of large volumes of data. Additionally, the adoption of these recommendations will benefit data users interested in moving large volumes of data from data systems to any other location. These data users include the cloud providers, cloud users such as scientists, and other users working in a high performance computing environment who need to move large volumes of data.

Radiotherapy is associated with significant improvement in local and regional control in Merkel cell carcinoma

PubMed Central

2012-01-01

Introduction Merkel cell carcinoma (MCC) is a rare tumour of skin. This study is a retrospective audit of patients with MCC from St Vincent’s and Mater Hospital, Sydney, Australia. The aim of this study was to investigate the influence of radiotherapy (RT) on the local and regional control of MCC lesions and survival of patients with MCC. Method The data bases in anatomical pathology, RT and surgery. We searched for patients having a diagnosis of MCC between 1996 and 2007. Patient, tumour and treatment characteristics were collected and analysed. Univariate survival analysis of categorical variables was conducted with the Kaplan-Meier method together with the Log-Rank test for statistical significance. Continuous variables were assessed using the Cox regression method. Multivariate analysis was performed for significant univariate results. Results Sixty seven patients were found. Sixty two who were stage I-III and were treated with radical intent were analysed. 68% were male. The median age was 74 years. Forty-two cases (68%) were stage I or II, and 20 cases (32%) were stage III. For the subset of 42 stage I and II patients, those that had RT to their primary site had a 2-year local recurrence free survival of 89% compared with 36% for patients not receiving RT (p<0.001). The cumulative 2-year regional recurrence free survival for patients having adjuvant regional RT was 84% compared with 43% for patients not receiving this treatment (p<0.001). Immune status at initial surgery was a significant predictor for OS and MCCSS. In a multivariate analysis combining macroscopic size (mm) and immune status at initial surgery, only immune status remained a significant predictor of overall survival (HR=2.096, 95% CI: 1.002-4.385, p=0.049). Conclusions RT is associated with significant improvement in local and regional control in Merkel cell carcinoma. Immunosuppression is an important factor in overall survival. PMID:23075308

Flexible deep-ultraviolet light-emitting diodes for significant improvement of quantum efficiencies by external bending

NASA Astrophysics Data System (ADS)

Shervin, Shahab; Oh, Seung Kyu; Park, Hyun Jung; Lee, Keon-Hwa; Asadirad, Mojtaba; Kim, Seung-Hwan; Kim, Jeomoh; Pouladi, Sara; Lee, Sung-Nam; Li, Xiaohang; Kwak, Joon Seop; Ryou, Jae-Hyun

2018-03-01

We report a new route to improve quantum efficiencies of AlGaN-based deep-ultraviolet light-emitting diodes (DUV LEDs) using mechanical flexibility of recently developed bendable thin-film structures. Numerical studies show that electronic band structures of AlGaN heterostructures and resulting optical and electrical characteristics of the devices can be significantly modified by external bending through active control of piezoelectric polarization. Internal quantum efficiency is enhanced higher than three times, when the DUV LEDs are moderately bent with concave curvatures. Furthermore, an efficiency droop at high injection currents is mitigated and turn-on voltage of diodes decreases with the same bending condition. The concept of bendable DUV LEDs with a controlled external strain can provide a new path for high-output-power and high-efficiency devices.

Insulin detemir improves glycemic control and reduces hypoglycemia in children with type 1 diabetes: findings from the Turkish cohort of the PREDICTIVE observational study.

PubMed

Kurtoglu, Selim; Atabek, Mehmet Emre; Dizdarer, Ceyhun; Pirgon, Ozgur; Isguven, Pinar; Emek, Sevil

2009-09-01

Insulin detemir is a basal insulin analog designed to produce a superior pharmacokinetic profile to basal formulations of human insulin. It has shown consistently improved tolerability in comparison to neutral protamine Hagedorn (NPH) insulin in adult cohorts, but there are relatively few publications involving pediatric cohorts. The efficacy and safety of insulin detemir in children with type 1 diabetes was assessed using data from the Turkish cohort of PREDICTIVE (a large, multinational, observational) study. The children investigated were using basal-bolus therapy involving NPH insulin or insulin glargine at baseline but were switched to insulin detemir as part of routine clinical care by their physicians. Twelve weeks of treatment with insulin detemir significantly reduced mean hemoglobin A1c (9.7-8.9%, p < 0.001) and mean fasting glucose [185-162 mg/dL (10.3-9 mmol/L), p < 0.01]. Fasting glucose variability was also lower after treatment with insulin detemir than previously (on either NPH or glargine, p < 0.05). The frequencies of total, major and nocturnal hypoglycemic events were significantly reduced with insulin detemir relative to baseline, with an estimated mean of 6.89 fewer events/patient/yr overall (p < 0.001) and 2.6 fewer nocturnal events/patient/yr (p < 0.01). Weight and insulin dose remained relatively unchanged. Twelve weeks of treatment with insulin detemir improved glycemic control and reduced hypoglycemia in children with type 1 diabetes. This improved tolerability might allow further dose titration and therefore additional improvements in glucose control.

Towards Improving Sea Ice Predictabiity: Evaluating Climate Models Against Satellite Sea Ice Observations

NASA Astrophysics Data System (ADS)

Stroeve, J. C.

2014-12-01

The last four decades have seen a remarkable decline in the spatial extent of the Arctic sea ice cover, presenting both challenges and opportunities to Arctic residents, government agencies and industry. After the record low extent in September 2007 effort has increased to improve seasonal, decadal-scale and longer-term predictions of the sea ice cover. Coupled global climate models (GCMs) consistently project that if greenhouse gas concentrations continue to rise, the eventual outcome will be a complete loss of the multiyear ice cover. However, confidence in these projections depends o HoHoweon the models ability to reproduce features of the present-day climate. Comparison between models participating in the World Climate Research Programme Coupled Model Intercomparison Project Phase 5 (CMIP5) and observations of sea ice extent and thickness show that (1) historical trends from 85% of the model ensemble members remain smaller than observed, and (2) spatial patterns of sea ice thickness are poorly represented in most models. Part of the explanation lies with a failure of models to represent details of the mean atmospheric circulation pattern that governs the transport and spatial distribution of sea ice. These results raise concerns regarding the ability of CMIP5 models to realistically represent the processes driving the decline of Arctic sea ice and to project the timing of when a seasonally ice-free Arctic may be realized. On shorter time-scales, seasonal sea ice prediction has been challenged to predict the sea ice extent from Arctic conditions a few months to a year in advance. Efforts such as the Sea Ice Outlook (SIO) project, originally organized through the Study of Environmental Change (SEARCH) and now managed by the Sea Ice Prediction Network project (SIPN) synthesize predictions of the September sea ice extent based on a variety of approaches, including heuristic, statistical and dynamical modeling. Analysis of SIO contributions reveals that when the

Global significance of a sub-Moho boundary layer (SMBL) deduced from high-resolution seismic observations

USGS Publications Warehouse

Fuchs, K.; Tittgemeyer, M.; Ryberg, T.; Wenzel, F.; Mooney, W.

2002-01-01

We infer the fine structure of a sub-Moho boundary layer (SMBL) at the top of the lithospheric mantle from high-resolution seismic observations of Peaceful Nuclear Explosions (PNE) on superlong-range profiles in Russia. Densely recorded seismograms permit recognition of previously unknown features of teleseismic propagation of the well known Pn and Sn phases, such as a band of incoherent, scattered, high-frequency seismic energy, developing consistently from station to station, apparent velocities of sub-Moho material, and high-frequency energy to distances of more than 3000 km with a coda band, incoherent at 10 km spacing and yet consistently observed to the end of the profiles. Estimates of the other key elements of the SMBL were obtained by finite difference calculations of wave propagation in elastic 2D models from a systematic grid search through parameter space. The SMBL consists of randomly distributed, mild velocity fluctuations of 2% or schlieren of high aspect ratios (???40) with long horizontal extent (???20 km) and therefore as thin as 0.5 km only; SMBL thickness is 60-100 km. It is suggested that the SMBL is of global significance as the physical base of the platewide observed high-frequency phases Pn and Sn. It is shown that wave propagation in the SMBL waveguide is insensitive to the background velocity distribution on which its schlieren are superimposed. This explains why the Pn and Sn phases traverse geological provinces of various age, heat flow, crustal thickness, and tectonic regimes. Their propagation appears to be independent of age. temperature, pressure, and stress. Dynamic stretching of mantle material during subduction or flow, possibly combined with chemical differentiation have to be considered as scale-forming processes in the upper mantle. However, it is difficult to distinguish with the present sets of Pn/Sn array data whether (and also where) the boundary layer is a frozen-in feature of paleo-processes or whether it is a response to

Improved ICU design reduces acquisition of antibiotic-resistant bacteria: a quasi-experimental observational study

PubMed Central

2011-01-01

Introduction The role of ICU design and particularly single-patient rooms in decreasing bacterial transmission between ICU patients has been debated. A recent change in our ICU allowed further investigation. Methods Pre-move ICU-A and pre-move ICU-B were open-plan units. In March 2007, ICU-A moved to single-patient rooms (post-move ICU-A). ICU-B remained unchanged (post-move ICU-B). The same physicians cover both ICUs. Cultures of specified resistant organisms in surveillance or clinical cultures from consecutive patients staying >48 hours were compared for the different ICUs and periods to assess the effect of ICU design on acquisition of resistant organisms. Results Data were collected for 62, 62, 44 and 39 patients from pre-move ICU-A, post-move ICU-A, pre-move ICU-B and post-move ICU-B, respectively. Fewer post-move ICU-A patients acquired resistant organisms (3/62, 5%) compared with post-move ICU-B patients (7/39, 18%; P = 0.043, P = 0.011 using survival analysis) or pre-move ICU-A patients (14/62, 23%; P = 0.004, P = 0.012 on survival analysis). Only the admission period was significant for acquisition of resistant organisms comparing pre-move ICU-A with post-move ICU-A (hazard ratio = 5.18, 95% confidence interval = 1.03 to 16.06; P = 0.025). More antibiotic-free days were recorded in post-move ICU-A (median = 3, interquartile range = 0 to 5) versus post-move ICU-B (median = 0, interquartile range = 0 to 4; P = 0.070) or pre-move ICU-A (median = 0, interquartile range = 0 to 4; P = 0.017). Adequate hand hygiene was observed on 140/242 (58%) occasions in post-move ICU-A versus 23/66 (35%) occasions in post-move ICU-B (P < 0.001). Conclusions Improved ICU design, and particularly use of single-patient rooms, decreases acquisition of resistant bacteria and antibiotic use. This observation should be considered in future ICU design. PMID:21914222

Improved ICU design reduces acquisition of antibiotic-resistant bacteria: a quasi-experimental observational study.

PubMed

Levin, Phillip D; Golovanevski, Mila; Moses, Allon E; Sprung, Charles L; Benenson, Shmuel

2011-01-01

The role of ICU design and particularly single-patient rooms in decreasing bacterial transmission between ICU patients has been debated. A recent change in our ICU allowed further investigation. Pre-move ICU-A and pre-move ICU-B were open-plan units. In March 2007, ICU-A moved to single-patient rooms (post-move ICU-A). ICU-B remained unchanged (post-move ICU-B). The same physicians cover both ICUs. Cultures of specified resistant organisms in surveillance or clinical cultures from consecutive patients staying >48 hours were compared for the different ICUs and periods to assess the effect of ICU design on acquisition of resistant organisms. Data were collected for 62, 62, 44 and 39 patients from pre-move ICU-A, post-move ICU-A, pre-move ICU-B and post-move ICU-B, respectively. Fewer post-move ICU-A patients acquired resistant organisms (3/62, 5%) compared with post-move ICU-B patients (7/39, 18%; P = 0.043, P = 0.011 using survival analysis) or pre-move ICU-A patients (14/62, 23%; P = 0.004, P = 0.012 on survival analysis). Only the admission period was significant for acquisition of resistant organisms comparing pre-move ICU-A with post-move ICU-A (hazard ratio = 5.18, 95% confidence interval = 1.03 to 16.06; P = 0.025). More antibiotic-free days were recorded in post-move ICU-A (median = 3, interquartile range = 0 to 5) versus post-move ICU-B (median = 0, interquartile range = 0 to 4; P = 0.070) or pre-move ICU-A (median = 0, interquartile range = 0 to 4; P = 0.017). Adequate hand hygiene was observed on 140/242 (58%) occasions in post-move ICU-A versus 23/66 (35%) occasions in post-move ICU-B (P < 0.001). Improved ICU design, and particularly use of single-patient rooms, decreases acquisition of resistant bacteria and antibiotic use. This observation should be considered in future ICU design.

Timescales for detecting a significant acceleration in sea level rise

PubMed Central

Haigh, Ivan D.; Wahl, Thomas; Rohling, Eelco J.; Price, René M.; Pattiaratchi, Charitha B.; Calafat, Francisco M.; Dangendorf, Sönke

2014-01-01

There is observational evidence that global sea level is rising and there is concern that the rate of rise will increase, significantly threatening coastal communities. However, considerable debate remains as to whether the rate of sea level rise is currently increasing and, if so, by how much. Here we provide new insights into sea level accelerations by applying the main methods that have been used previously to search for accelerations in historical data, to identify the timings (with uncertainties) at which accelerations might first be recognized in a statistically significant manner (if not apparent already) in sea level records that we have artificially extended to 2100. We find that the most important approach to earliest possible detection of a significant sea level acceleration lies in improved understanding (and subsequent removal) of interannual to multidecadal variability in sea level records. PMID:24728012

Significant Improvements in Pyranometer Nighttime Offsets Using High-Flow DC Ventilation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kutchenreiter, Mark; Michalski, J.J.; Long, C.N.

2017-05-22

Accurate solar radiation measurements using pyranometers are required to understand radiative impacts on the Earth's energy budget, solar energy production, and to validate radiative transfer models. Ventilators of pyranometers, which are used to keep the domes clean and dry, also affect instrument thermal offset accuracy. This poster presents a high-level overview of the ventilators for single-black-detector pyranometers and black-and-white pyranometers. For single-black-detector pyranometers with ventilators, high-flow-rate (50-CFM and higher), 12-V DC fans lower the offsets, lower the scatter, and improve the predictability of nighttime offsets compared to lower-flow-rate (35-CFM), 120-V AC fans operated in the same type of environmental setup.more » Black-and-white pyranometers, which are used to measure diffuse horizontal irradiance, sometimes show minor improvement with DC fan ventilation, but their offsets are always small, usually no more than 1 W/m2, whether AC- or DC-ventilated.« less

Use of a hand-held computer observational tool to improve communication for care planning and psychosocial well-being

PubMed Central

Corazzini, Kirsten; Rapp, Carla Gene; McConnell, Eleanor S.; Anderson, Ruth A.

2013-01-01

Staff development nurses in long-term care are challenged to implement training programs that foster quality unlicensed assistive personnel (UAP) care and improve the transfer of their observations to licensed nursing staff for care planning. This study describes the outcomes of a program where UAP recorded behavioral problems of residents to inform care. Findings suggest staff development nurses who aim to improve UAP reporting without simultaneously targeting licensed nursing staff behaviors may worsen nursing staff relationships. PMID:19182546

Sensor Web Dynamic Measurement Techniques and Adaptive Observing Strategies

NASA Technical Reports Server (NTRS)

Talabac, Stephen J.

2004-01-01

Sensor Web observing systems may have the potential to significantly improve our ability to monitor, understand, and predict the evolution of rapidly evolving, transient, or variable environmental features and events. This improvement will come about by integrating novel data collection techniques, new or improved instruments, emerging communications technologies and protocols, sensor mark-up languages, and interoperable planning and scheduling systems. In contrast to today's observing systems, "event-driven" sensor webs will synthesize real- or near-real time measurements and information from other platforms and then react by reconfiguring the platforms and instruments to invoke new measurement modes and adaptive observation strategies. Similarly, "model-driven" sensor webs will utilize environmental prediction models to initiate targeted sensor measurements or to use a new observing strategy. The sensor web concept contrasts with today's data collection techniques and observing system operations concepts where independent measurements are made by remote sensing and in situ platforms that do not share, and therefore cannot act upon, potentially useful complementary sensor measurement data and platform state information. This presentation describes NASA's view of event-driven and model-driven Sensor Webs and highlights several research and development activities at the Goddard Space Flight Center.

Significant improvement in the electrical characteristics of Schottky barrier diodes on molecularly modified Gallium Nitride surfaces

NASA Astrophysics Data System (ADS)

Garg, Manjari; Naik, Tejas R.; Pathak, C. S.; Nagarajan, S.; Rao, V. Ramgopal; Singh, R.

2018-04-01

III-Nitride semiconductors face the issue of localized surface states, which causes fermi level pinning and large leakage current at the metal semiconductor interface, thereby degrading the device performance. In this work, we have demonstrated the use of a Self-Assembled Monolayer (SAM) of organic molecules to improve the electrical characteristics of Schottky barrier diodes (SBDs) on n-type Gallium Nitride (n-GaN) epitaxial films. The electrical characteristics of diodes were improved by adsorption of SAM of hydroxyl-phenyl metallated porphyrin organic molecules (Zn-TPPOH) onto the surface of n-GaN. SAM-semiconductor bonding via native oxide on the n-GaN surface was confirmed using X-ray photoelectron spectroscopy measurements. Surface morphology and surface electronic properties were characterized using atomic force microscopy and Kelvin probe force microscopy. Current-voltage characteristics of different metal (Cu, Ni) SBDs on bare n-GaN were compared with those of Cu/Zn-TPPOH/n-GaN and Ni/Zn-TPPOH/n-GaN SBDs. It was found that due to the molecular monolayer, the surface potential of n-GaN was decreased by ˜350 mV. This caused an increase in the Schottky barrier height of Cu and Ni SBDs from 1.13 eV to 1.38 eV and 1.07 eV to 1.22 eV, respectively. In addition to this, the reverse bias leakage current was reduced by 3-4 orders of magnitude for both Cu and Ni SBDs. Such a significant improvement in the electrical performance of the diodes can be very useful for better device functioning.

Nicotine Significantly Improves Chronic Stress-Induced Impairments of Cognition and Synaptic Plasticity in Mice.

PubMed

Shang, Xueliang; Shang, Yingchun; Fu, Jingxuan; Zhang, Tao

2017-08-01

The aim of this study was to examine if nicotine was able to improve cognition deficits in a mouse model of chronic mild stress. Twenty-four male C57BL/6 mice were divided into three groups: control, stress, and stress with nicotine treatment. The animal model was established by combining chronic unpredictable mild stress (CUMS) and isolated feeding. Mice were exposed to CUMS continued for 28 days, while nicotine (0.2 mg/kg) was also administrated for 28 days. Weight and sucrose consumption were measured during model establishing period. The anxiety and behavioral despair were analyzed using the forced swim test (FST) and open-field test (OFT). Spatial cognition was evaluated using Morris water maze (MWM) test. Following behavioral assessment, both long-term potentiation (LTP) and depotentiation (DEP) were recorded in the hippocampal dentate gyrus (DG) region. Both synaptic and Notch1 proteins were measured by Western. Nicotine increased stressed mouse's sucrose consumption. The MWM test showed that spatial learning and reversal learning in stressed animals were remarkably affected relative to controls, whereas nicotine partially rescued cognitive functions. Additionally, nicotine considerably alleviated the level of anxiety and the degree of behavioral despair in stressed mice. It effectively mitigated the depression-induced impairment of hippocampal synaptic plasticity, in which both the LTP and DEP were significantly inhibited in stressed mice. Moreover, nicotine enhanced the expression of synaptic and Notch1 proteins in stressed animals. The results suggest that nicotine ameliorates the depression-like symptoms and improves the hippocampal synaptic plasticity closely associated with activating transmembrane ion channel receptors and Notch signaling components. Graphical Abstract ᅟ.

Significantly Improving Regional Seismic Amplitude Tomography at Higher Frequencies by Determining S -Wave Bandwidth

DOE PAGES

Fisk, Mark D.; Pasyanos, Michael E.

2016-05-03

Characterizing regional seismic signals continues to be a difficult problem due to their variability. Calibration of these signals is very important to many aspects of monitoring underground nuclear explosions, including detecting seismic signals, discriminating explosions from earthquakes, and reliably estimating magnitude and yield. Amplitude tomography, which simultaneously inverts for source, propagation, and site effects, is a leading method of calibrating these signals. A major issue in amplitude tomography is the data quality of the input amplitude measurements. Pre-event and prephase signal-to-noise ratio (SNR) tests are typically used but can frequently include bad signals and exclude good signals. The deficiencies ofmore » SNR criteria, which are demonstrated here, lead to large calibration errors. To ameliorate these issues, we introduce a semi-automated approach to assess the bandwidth of a spectrum where it behaves physically. We determine the maximum frequency (denoted as F max) where it deviates from this behavior due to inflections at which noise or spurious signals start to bias the spectra away from the expected decay. We compare two amplitude tomography runs using the SNR and new F max criteria and show significant improvements to the stability and accuracy of the tomography output for frequency bands higher than 2 Hz by using our assessments of valid S-wave bandwidth. We compare Q estimates, P/S residuals, and some detailed results to explain the improvements. Lastly, for frequency bands higher than 4 Hz, needed for effective P/S discrimination of explosions from earthquakes, the new bandwidth criteria sufficiently fix the instabilities and errors so that the residuals and calibration terms are useful for application.« less

Data assimilation in integrated hydrological modelling in the presence of observation bias

NASA Astrophysics Data System (ADS)

Rasmussen, J.; Madsen, H.; Jensen, K. H.; Refsgaard, J. C.

2015-08-01

The use of bias-aware Kalman filters for estimating and correcting observation bias in groundwater head observations is evaluated using both synthetic and real observations. In the synthetic test, groundwater head observations with a constant bias and unbiased stream discharge observations are assimilated in a catchment scale integrated hydrological model with the aim of updating stream discharge and groundwater head, as well as several model parameters relating to both stream flow and groundwater modeling. The Colored Noise Kalman filter (ColKF) and the Separate bias Kalman filter (SepKF) are tested and evaluated for correcting the observation biases. The study found that both methods were able to estimate most of the biases and that using any of the two bias estimation methods resulted in significant improvements over using a bias-unaware Kalman Filter. While the convergence of the ColKF was significantly faster than the convergence of the SepKF, a much larger ensemble size was required as the estimation of biases would otherwise fail. Real observations of groundwater head and stream discharge were also assimilated, resulting in improved stream flow modeling in terms of an increased Nash-Sutcliffe coefficient while no clear improvement in groundwater head modeling was observed. Both the ColKF and the SepKF tended to underestimate the biases, which resulted in drifting model behavior and sub-optimal parameter estimation, but both methods provided better state updating and parameter estimation than using a bias-unaware filter.

Data assimilation in integrated hydrological modelling in the presence of observation bias

NASA Astrophysics Data System (ADS)

Rasmussen, Jørn; Madsen, Henrik; Høgh Jensen, Karsten; Refsgaard, Jens Christian

2016-05-01

The use of bias-aware Kalman filters for estimating and correcting observation bias in groundwater head observations is evaluated using both synthetic and real observations. In the synthetic test, groundwater head observations with a constant bias and unbiased stream discharge observations are assimilated in a catchment-scale integrated hydrological model with the aim of updating stream discharge and groundwater head, as well as several model parameters relating to both streamflow and groundwater modelling. The coloured noise Kalman filter (ColKF) and the separate-bias Kalman filter (SepKF) are tested and evaluated for correcting the observation biases. The study found that both methods were able to estimate most of the biases and that using any of the two bias estimation methods resulted in significant improvements over using a bias-unaware Kalman filter. While the convergence of the ColKF was significantly faster than the convergence of the SepKF, a much larger ensemble size was required as the estimation of biases would otherwise fail. Real observations of groundwater head and stream discharge were also assimilated, resulting in improved streamflow modelling in terms of an increased Nash-Sutcliffe coefficient while no clear improvement in groundwater head modelling was observed. Both the ColKF and the SepKF tended to underestimate the biases, which resulted in drifting model behaviour and sub-optimal parameter estimation, but both methods provided better state updating and parameter estimation than using a bias-unaware filter.

Effects of a community scorecard on improving the local health system in Eastern Democratic Republic of Congo: qualitative evidence using the most significant change technique.

PubMed

Ho, Lara S; Labrecque, Guillaume; Batonon, Isatou; Salsi, Viviana; Ratnayake, Ruwan

2015-01-01

More than a decade of conflict has weakened the health system in the Democratic Republic of Congo and decreased its ability to respond to the needs of the population. Community scorecards have been conceived as a way to increase accountability and responsiveness of service providers, but there is limited evidence of their effects, particularly in fragile and conflict-affected contexts. This paper describes the implementation of community scorecards within a community-driven reconstruction project in two provinces of eastern Democratic Republic of Congo. Between June 2012 and November 2013, 45 stories of change in the health system were collected from village development committee, health committee, community members (20 men and 18 women) and healthcare providers (n = 7) in 25 sites using the Most Significant Change technique. Stories were analyzed qualitatively for content related to the types and mechanisms of change observed. The most salient changes were related to increased transparency and community participation in health facility management, and improved quality of care. Quality of care included increased access to services, improved patient-provider relationships, improved performance of service providers, and improved maintenance of physical infrastructure. Changes occurred through many different mechanisms including provider actions in response to information, pressure from community representatives, or supervisors; and joint action and improved collaboration by health facility committees and providers. Although it is often assumed that confrontation is a primary mechanism for citizens to change state-provided services, this study demonstrates that healthcare providers may also be motivated to change through other means. Positive experiences of community scorecards can provide a structured space for interface between community members and the health system, allowing users to voice their opinions and preferences and bridge information gaps for both

Implementation of a Multidisciplinary Bleeding and Transfusion Protocol Significantly Decreases Perioperative Blood Product Utilization and Improves Some Bleeding Outcomes.

PubMed

Timpa, Joseph G; O'Meara, L Carlisle; Goldberg, Kellen G; Phillips, Jay P; Crawford, Jack H; Jackson, Kimberly W; Alten, Jeffrey A

2016-03-01

Perioperative transfusion of blood products is associated with increased morbidity and mortality after pediatric cardiac surgery. We report the results of a quality improvement project aimed at decreasing perioperative blood product administration and bleeding after pediatric cardiopulmonary bypass (CPB) surgery. A multidisciplinary team evaluated baseline data from 99 consecutive CPB patients, focusing on the variability in transfusion management and bleeding outcomes, to create a standardized bleeding and transfusion management protocol. A total of 62 subsequent patients were evaluated after implementation of the protocol: 17 with single pass hemoconcentrated (SPHC) blood transfusion and 45 with modified ultrafiltration (MUF). Implementation of the protocol with SPHC blood led to significant decrease in transfusion of every blood product in the cardiovascular operating room and first 6 hours in cardiovascular intensive care unit ([CVICU] p < .05). Addition of MUF to the protocol led to further decrease in transfusion of all blood products compared to preprotocol. Patients <2 months old had 49% decrease in total blood product administration: 155 mL/kg preprotocol, 117 mL/kg protocol plus SPHC, and 79 mL/kg protocol plus MUF (p < .01). There were significant decreases in postoperative bleeding in the first hour after CVICU admission: 6 mL/kg preprotocol, 3.8 mL/kg protocol plus SPHC, and 2 mL/kg protocol plusMUF (p = .02). There was also significantly decreased incidence of severe postoperative bleeding (>10 mL/kg) in the first CVICU hour for protocol plus MUF patients (p < .01). Implementation of a multidisciplinary bleeding and transfusion protocol significantly decreases perioperative blood product transfusion and improves some bleeding outcomes.

In situ earthworm breeding in orchards significantly improves the growth, quality and yield of papaya (Carica papaya L.)

PubMed Central

Xiang, Huimin; Guo, Lei; Zhao, Benliang

2016-01-01

The aim of this study was to compare the effects of four fertilizer applications—control (C), chemical fertilizer (F), compost (O), and in situ earthworm breeding (E)—on the growth, quality and yield of papaya (Carica papaya L.). In this study, 5 g plant−1 urea (CH4N2O, %N = 46.3%) and 100 g plant−1 microelement fertilizer was applied to each treatment. The fertilizer applications of these four treatments are different from each other. The results showed that the E treatment had the highest growth parameters over the whole growth period. At 127 days after transplantation, the order of plant heights from greatest to smallest was E > F > O > C, and the stem diameters were E > F > O > C, with significant differences between all treatments. Soluble-solid, sugar, vitamin C, and protein content significantly increased in the E treatment. In addition, the total acid and the electrical conductivity of the fruit significantly decreased in the E treatment. Fruit firmness clearly increased in the O treatment, and decreased in the F treatment. The fresh individual fruit weights, fruit numbers, and total yields were greatly improved in the F and E treatments, and the total yield of the E treatment was higher than that in the F treatment. In conclusion, the in situ earthworm breeding treatment performed better than conventional compost and chemical fertilizer treatments. Furthermore, in situ earthworm breeding may be a potential organic fertilizer application in orchards because it not only improves the fruit quality and yield but also reduces the amount of organic wastes from agriculture as a result of the activities of earthworms. PMID:27994969

[Clinical efficacy observation of acupuncture at suliao (GV 25) on improving regain of consciousness from coma in severe craniocerebral injury].

PubMed

Xu, Kai-Sheng; Song, Jian-Hua; Huang, Tiao-Hua; Huang, Zhi-Hua; Yu, Lu-Chang; Zheng, Wei-Ping; Chen, Xiao-Shan; Liu, Chuan

2014-06-01

To compare the clinical therapeutic effects differences between acupuncture at Suliao (GV 25) and Shuigou (GV 26) on promoting regain of consciousness from coma in severe craniocerebral injury. Based on regular emergency treatments of neurosurgery, eighty-two cases of craniocerebral injury who were under stable condition were randomly divided into an observation group (42 cases) and a control group (40 cases). Suliao (GV 25) was selected as main aupoint, while Laogong (PC 8) and Yongquan (KI 1), etc. were selected as adjuvant acupoints and Neiguan (PC 6), Sanyinjiao (SP 6), Yifeng (TE 17) and Wangu (GB 12), etc. were selected as matching acupoints in the observation group where a strong needle manipulation was applied to improve the regain of consciousness. The main acupoint of Shuigou (GV 26) along with identical adjuvant acupoints and matching acupoints in the observation group were selected in the control group with identical strong needle manipulation. The treatment was given once a day in both groups, five times per week and ten times were considered as one session. The immediate clinical symptoms after acupuncture at Suliao (GV 25) and Shuigou (GV 26) were observed as well as Glasgow coma scale (GCS) before the treatment, after 45 days and 90 days of treatment to assess the resuscitation time and rate. Also the clinical efficacy was compared between both groups. The occurrence rate of sneezing reflex was 85.7% (36/42) in the observation group, which was higher than 25.0% (10/40) in the control group (P < 0.01). The average resuscitation time was (64.6 +/- 19.4) days in the observation group, which was obviously shorter than (73.8 +/- 14. 6) days in the control group (P < 0.05). The resuscitation rate was 88.1% (37/42) in the observation group, which was similar to 75.0% (30/40) in the control group (P > 0.05). Compared before the treatment, GCS were both improved after the treatment in two groups (both P < 0.01). The 90-day GCS was 9.52 +/- 2.32 in the

Muscle Oxygen Saturation Improves Diagnostic Association Between Initial Vital Signs and Major Hemorrhage: A Prospective Observational Study.

PubMed

Reisner, Andrew T; Edla, Shwetha; Liu, Jianbo; Rubin, John T; Thorsen, Jill E; Kittell, Erin; Smith, Jason B; Yeh, Daniel D; Reifman, Jaques

2016-03-01

During initial assessment of trauma patients, vital signs do not identify all patients with life-threatening hemorrhage. We hypothesized that a novel vital sign, muscle oxygen saturation (SmO2 ), could provide independent diagnostic information beyond routine vital signs for identification of hemorrhaging patients who require packed red blood cell (RBC) transfusion. This was an observational study of adult trauma patients treated at a Level I trauma center. Study staff placed the CareGuide 1100 tissue oximeter (Reflectance Medical Inc., Westborough, MA), and we analyzed average values of SmO2 , systolic blood pressure (sBP), pulse pressure (PP), and heart rate (HR) during 10 minutes of early emergency department evaluation. We excluded subjects without a full set of vital signs during the observation interval. The study outcome was hemorrhagic injury and RBC transfusion ≥ 3 units in 24 hours (24-hr RBC ≥ 3). To test the hypothesis that SmO2 added independent information beyond routine vital signs, we developed one logistic regression model with HR, sBP, and PP and one with SmO2 in addition to HR, sBP, and PP and compared their areas under receiver operating characteristic curves (ROC AUCs) using DeLong's test. We enrolled 487 subjects; 23 received 24-hr RBC ≥ 3. Compared to the model without SmO2 , the regression model with SmO2 had a significantly increased ROC AUC for the prediction of ≥ 3 units of 24-hr RBC volume, 0.85 (95% confidence interval [CI], 0.75-0.91) versus 0.77 (95% CI, 0.66-0.86; p < 0.05 per DeLong's test). Results were similar for ROC AUCs predicting patients (n = 11) receiving 24-hr RBC ≥ 9. SmO2 significantly improved the diagnostic association between initial vital signs and hemorrhagic injury with blood transfusion. This parameter may enhance the early identification of patients who require blood products for life-threatening hemorrhage. © 2016 The Authors. Academic Emergency Medicine published by Wiley Periodicals, Inc. on behalf

Improving Access to and Use of Ocean Observations from Animal Borne Sensors Project TOPP-ONR-IOOS

DTIC Science & Technology

2012-09-30

oxygen and pH sensors) in response to growing concerns about the potential impacts of ocean acidification and hypoxia on marine biological resources and...1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. Improving access to and use of ocean observations...from animal borne sensors project TOPP-ONR-IOOS Barbara Block Stanford University Hopkins Marine Station 120 Ocean View Blvd Pacific Grove

Significant Improvements in Pyranometer Nighttime Offsets Using High-Flow DC Ventilation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Michalsky, Joseph J.; Kutchenreiter, Mark; Long, Charles N.

Ventilators are used to keep the domes of pyranometers clean and dry, but they affect the nighttime offset as well. This paper examines different ventilation strategies. For the several commercial single-black-detector pyranometers with ventilators examined here, high flow rate (50 CFM and higher), 12 VDC fans lower the offsets, lower the scatter, and improve the predictability of the offsets during the night compared with lower flow rate 35 CFM, 120 VAC fans operated in the same ventilator housings. Black-and-white pyranometers sometimes show improvement with DC ventilation, but in some cases DC ventilation makes the offsets slightly worse. Since the offsetsmore » for these black-and-white pyranometers are always small, usually no more than 1 Wm -2, whether AC or DC ventilated, changing their ventilation to higher CFM DC ventilation is not imperative. Future work should include all major manufacturers of pyranometers and unventilated, as well as, ventilated pyranometers. Lastly, an important outcome of future research will be to clarify under what circumstances nighttime data can be used to predict daytime offsets.« less

Significant Improvements in Pyranometer Nighttime Offsets Using High-Flow DC Ventilation

DOE PAGES

Michalsky, Joseph J.; Kutchenreiter, Mark; Long, Charles N.

2017-06-20

Ventilators are used to keep the domes of pyranometers clean and dry, but they affect the nighttime offset as well. This paper examines different ventilation strategies. For the several commercial single-black-detector pyranometers with ventilators examined here, high flow rate (50 CFM and higher), 12 VDC fans lower the offsets, lower the scatter, and improve the predictability of the offsets during the night compared with lower flow rate 35 CFM, 120 VAC fans operated in the same ventilator housings. Black-and-white pyranometers sometimes show improvement with DC ventilation, but in some cases DC ventilation makes the offsets slightly worse. Since the offsetsmore » for these black-and-white pyranometers are always small, usually no more than 1 Wm -2, whether AC or DC ventilated, changing their ventilation to higher CFM DC ventilation is not imperative. Future work should include all major manufacturers of pyranometers and unventilated, as well as, ventilated pyranometers. Lastly, an important outcome of future research will be to clarify under what circumstances nighttime data can be used to predict daytime offsets.« less

Combining Passive Microwave Sounders with CYGNSS information for improved retrievals: Observations during Hurricane Harvey

NASA Astrophysics Data System (ADS)

Schreier, M. M.

2017-12-01

The launch of CYGNSS (Cyclone Global Navigation Satellite System) has added an interesting component to satellite observations: it can provide wind speeds in the tropical area with a high repetition rate. Passive microwave sounders that are overpassing the same region can benefit from this information, when it comes to the retrieval of temperature or water profiles: the uncertainty about wind speeds has a strong impact on emissivity and reflectivity calculations with respect to surface temperature. This has strong influences on the uncertainty of retrieval of temperature and water content, especially under extreme weather conditions. Adding CYGNSS information to the retrieval can help to reduce errors and provide a significantly better sounder retrieval. Based on observations during Hurricane Harvey, we want to show the impact of CYGNSS data on the retrieval of passive microwave sensors. We will show examples on the impact on the retrieval from polar orbiting instruments, like the Advanced Technology Microwave Sounder (ATMS) and AMSU-A/B on NOAA-18 and 19. In addition we will also show the impact on retrievals from HAMSR (High Altitude MMIC Sounding Radiometer), which was flying on the Global Hawk during the EPOCH campaign. We will compare the results with other observations and estimate the impact of additional CYGNSS information on the microwave retrieval, especially on the impact in error and uncertainty reduction. We think, that a synergetic use of these different data sources could significantly help to produce better assimilation products for forecast assimilation.

Liquid human milk fortifier significantly improves docosahexaenoic and arachidonic acid status in preterm infants.

PubMed

Berseth, C L; Harris, C L; Wampler, J L; Hoffman, D R; Diersen-Schade, D A

2014-09-01

We report the fatty acid composition of mother׳s own human milk from one of the largest US cohorts of lactating mothers of preterm infants. Milk fatty acid data were used as a proxy for intake at enrollment in infants (n=150) who received human milk with a powder human milk fortifier (HMF; Control) or liquid HMF [LHMF; provided additional 12mg docosahexaenoic acid (DHA), 20mg arachidonic acid (ARA)/100mL human milk]. Mothers provided milk samples (n=129) and reported maternal DHA consumption (n=128). Infant blood samples were drawn at study completion (Study Day 28). Human milk and infant PPL fatty acids were analyzed using capillary column gas chromatography. DHA and ARA were within ranges previously published for US term and preterm human milk. Compared to Control HMF (providing no DHA or ARA), human milk fortified with LHMF significantly increased infant PPL DHA and ARA and improved preterm infant DHA and ARA status. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

Inviting Observation

ERIC Educational Resources Information Center

Hansen, Spencer D.

2010-01-01

Monthly meetings and a peer-observation program help novice teachers overcome isolation and practice new skills that support improved student learning. Peer observation is not without its difficulties. Above all else, the point of the program is to make teachers more comfortable observing, sharing instructional ideas, and learning from one…

Perceptual learning improves stereoacuity in amblyopia.

PubMed

Xi, Jie; Jia, Wu-Li; Feng, Li-Xia; Lu, Zhong-Lin; Huang, Chang-Bing

2014-04-15

Amblyopia is a developmental disorder that results in both monocular and binocular deficits. Although traditional treatment in clinical practice (i.e., refractive correction, or occlusion by patching and penalization of the fellow eye) is effective in restoring monocular visual acuity, there is little information on how binocular function, especially stereopsis, responds to traditional amblyopia treatment. We aim to evaluate the effects of perceptual learning on stereopsis in observers with amblyopia in the current study. Eleven observers (21.1 ± 5.1 years, six females) with anisometropic or ametropic amblyopia were trained to judge depth in 10 to 13 sessions. Red-green glasses were used to present three different texture anaglyphs with different disparities but a fixed exposure duration. Stereoacuity was assessed with the Fly Stereo Acuity Test and visual acuity was assessed with the Chinese Tumbling E Chart before and after training. Averaged across observers, training significantly reduced disparity threshold from 776.7″ to 490.4″ (P < 0.01) and improved stereoacuity from 200.3″ to 81.6″ (P < 0.01). Interestingly, visual acuity also significantly improved from 0.44 to 0.35 logMAR (approximately 0.9 lines, P < 0.05) in the amblyopic eye after training. Moreover, the learning effects in two of the three retested observers were largely retained over a 5-month period. Perceptual learning is effective in improving stereo vision in observers with amblyopia. These results, together with previous evidence, suggest that structured monocular and binocular training might be necessary to fully recover degraded visual functions in amblyopia. Chinese Abstract.

Thirty Years of Improving the NCEP Global Forecast System

NASA Astrophysics Data System (ADS)

White, G. H.; Manikin, G.; Yang, F.

2014-12-01

Current eight day forecasts by the NCEP Global Forecast System are as accurate as five day forecasts 30 years ago. This revolution in weather forecasting reflects increases in computer power, improvements in the assimilation of observations, especially satellite data, improvements in model physics, improvements in observations and international cooperation and competition. One important component has been and is the diagnosis, evaluation and reduction of systematic errors. The effect of proposed improvements in the GFS on systematic errors is one component of the thorough testing of such improvements by the Global Climate and Weather Modeling Branch. Examples of reductions in systematic errors in zonal mean temperatures and winds and other fields will be presented. One challenge in evaluating systematic errors is uncertainty in what reality is. Model initial states can be regarded as the best overall depiction of the atmosphere, but can be misleading in areas of few observations or for fields not well observed such as humidity or precipitation over the oceans. Verification of model physics is particularly difficult. The Environmental Modeling Center emphasizes the evaluation of systematic biases against observations. Recently EMC has placed greater emphasis on synoptic evaluation and on precipitation, 2-meter temperatures and dew points and 10 meter winds. A weekly EMC map discussion reviews the performance of many models over the United States and has helped diagnose and alleviate significant systematic errors in the GFS, including a near surface summertime evening cold wet bias over the eastern US and a multi-week period when the GFS persistently developed bogus tropical storms off Central America. The GFS exhibits a wet bias for light rain and a dry bias for moderate to heavy rain over the continental United States. Significant changes to the GFS are scheduled to be implemented in the fall of 2014. These include higher resolution, improved physics and

Using a Service Planning Approach to Improve the Impact of Earth Observations in the Developing World

NASA Astrophysics Data System (ADS)

Irwin, D.; Frankel-Reed, J.

2017-12-01

SERVIR is joint development initiative of the National Aeronautics and Space Administration (NASA) and the United States Agency for International Development (USAID), working in partnership with leading regional organizations around the world to help developing countries use information provided by Earth observing satellites and geospatial technologies to empower decision-makers with tools, products, and services to better address critical issues related to food security, water resources, natural disasters, and land use. Since its launch in 2005, SERVIR has grown into a global network of four active hubs that are improving awareness, increasing access to information, and supporting analysis to help people in Africa, Hindu Kush Himalaya, and the Lower Mekong regions better manage today's complex environmental challenges. To help improve the impact of SERVIR activities throughout the global network, a Service Planning Approach was developed with three main steps that involve: 1) consultation and needs assessment, 2) service design and 3) service delivery. To successfully accomplish these steps, SERVIR has created a series of capacity building tools that focus on specific activities to better engage stakeholders, design a more successful service, and to conduct end-to-end monitoring, evaluation, and learning. Currently, all four SERVIR hubs in different regions of the world are implementing this Service Planning Approach and helping to improve it by providing feedback based on their implementation. This presentation will describe the SERVIR Service Planning Approach and discuss the various tools, which ultimately can empower remote sensing scientists and application developers to obtain a greater impact from the Earth Observation products they develop.

Improving irrigation and groundwater parameterizations in the Community Land Model (CLM) using in-situ observations and satellite data

NASA Astrophysics Data System (ADS)

Felfelani, F.; Pokhrel, Y. N.

2017-12-01

In this study, we use in-situ observations and satellite data of soil moisture and groundwater to improve irrigation and groundwater parameterizations in the version 4.5 of the Community Land Model (CLM). The irrigation application trigger, which is based on the soil moisture deficit mechanism, is enhanced by integrating soil moisture observations and the data from the Soil Moisture Active Passive (SMAP) mission which is available since 2015. Further, we incorporate different irrigation application mechanisms based on schemes used in various other land surface models (LSMs) and carry out a sensitivity analysis using point simulations at two different irrigated sites in Mead, Nebraska where data from the AmeriFlux observational network are available. We then conduct regional simulations over the entire High Plains region and evaluate model results with the available irrigation water use data at the county-scale. Finally, we present results of groundwater simulations by implementing a simple pumping scheme based on our previous studies. Results from the implementation of current irrigation parameterization used in various LSMs show relatively large difference in vertical soil moisture content profile (e.g., 0.2 mm3/mm3) at point scale which is mostly decreased when averaged over relatively large regions (e.g., 0.04 mm3/mm3 in the High Plains region). It is found that original irrigation module in CLM 4.5 tends to overestimate the soil moisture content compared to both point observations and SMAP, and the results from the improved scheme linked with the groundwater pumping scheme show better agreement with the observations.

Sensor performance considerations for aviation weather observations for the NOAA Consolidated Observations Requirements List (CORL CT-AWX)

NASA Astrophysics Data System (ADS)

Murray, John; Helms, David; Miner, Cecilia

2008-08-01

Airspace system demand is expected to increase as much as 300 percent by the year 2025 and the Next Generation Air Transportation System (NextGen) is being developed to accommodate the super-density operations that this will entail. Concomitantly, significant improvements in observations and forecasting are being undertaken to support NextGen which will require greatly improved and more uniformly applied data for aviation weather hazards and constraints which typically comprise storm-scale and microscale observables. Various phenomena are associated with these hazards and constraints such as convective weather, in-flight icing, turbulence, and volcanic ash as well as more mundane aviation parameters such as cloud tops and bases and fuel-freeze temperatures at various flight levels. Emerging problems for aviation in space weather and the environmental impacts of aviation are also occurring at these scales. Until recently, the threshold and objective observational requirements for these observables had not been comprehensively documented in a single, authoritative source. Scientists at NASA and NOAA have recently completed this task and have established baseline observational requirements for the Next Generation Air Transportation System (NextGen) and expanded and updated the NOAA Consolidated Observations Requirements List (CORL) for Aviation (CT-AWX) to better inform National Weather Service investments for current and future observing systems. This paper describes the process and results of this effort. These comprehensive aviation observation requirements will now be used to conduct gap analyses for the aviation component of the Integrated Earth Observing System and to inform the investment strategies of the FAA, NASA, and NOAA that are needed to develop the observational architecture to support NextGen and other users of storm and microscale observations.

Significant improvement of a clinical training course in physical examination after basic structural changes in the teaching content and methods.

PubMed

Sonne, Carolin; Vogelmann, Roger; Lesevic, H; Bott-Flügel, Lorenz; Ott, I; Seyfarth, Melchior

2013-01-01

Regular student evaluations at the Technical University Munich indicate the necessity for improvement of the clinical examination course. The aim of this study was to examine if targeted measures to restructure and improve a clinical examination course session lead to a higher level of student satisfaction as well as better self-assessment of the acquired techniques of clinical examination. At three medical departments of the Technical University Munich during the 2010 summer semester, the quantitative results of 49 student evaluations (ratings 1-6, German scholastic grading system) of the clinical examination course were compared for a course before and a course after structured measures for improvement. These measures included structured teaching instructions, handouts and additional material from the Internet. 47 evaluations were completed before and 34 evaluations after the measures for improvement. The measures named above led to a significant improvement of the evaluative ratings in the following areas: short introduction to the topic of each clinical examination course (from 2.4±1.2 to1.7±1.0; p=0.0020) and to basic measures of hygiene (from 3.8±1.9 to 2.5±1.8; p=0.004), structured demonstration of each clinical examination step (from 2.9±1.5 to 1.8±1.0; p=0.001), sufficient practice of each clinical examination step (from 3.1±1.8 to 2.2±1.4; p=0.030) structured feedback on each clinical examination step (from 3.0±1.4 to 2.3±1.0; p=0.0070), use of handouts (from 5.2±1.4 to 1.8±1.4; p<0.001), advice on additional learning material (from 5.0±1.4 to 3.4±2.0; p<0.001), general learning experience (from 2.4±0.9 to 1.9±0.8; p=0.017), and self-assessment of the acquired techniques of clinical examination (from 3.5±1.3 to 2.5±1.1; p<0.01). Structured changes led to significant improvement in the evaluative ratings of a clinical examination course session concerning preparation of the tutors, structure of the course, and confidence in performing

Factoring local sequence composition in motif significance analysis.

PubMed

Ng, Patrick; Keich, Uri

2008-01-01

We recently introduced a biologically realistic and reliable significance analysis of the output of a popular class of motif finders. In this paper we further improve our significance analysis by incorporating local base composition information. Relying on realistic biological data simulation, as well as on FDR analysis applied to real data, we show that our method is significantly better than the increasingly popular practice of using the normal approximation to estimate the significance of a finder's output. Finally we turn to leveraging our reliable significance analysis to improve the actual motif finding task. Specifically, endowing a variant of the Gibbs Sampler with our improved significance analysis we demonstrate that de novo finders can perform better than has been perceived. Significantly, our new variant outperforms all the finders reviewed in a recently published comprehensive analysis of the Harbison genome-wide binding location data. Interestingly, many of these finders incorporate additional information such as nucleosome positioning and the significance of binding data.

Factors of U.S. Hospitals Associated with Improved Profit Margins: An Observational Study.

PubMed

Ly, Dan P; Cutler, David M

2018-02-14

Hospitals face financial pressure from decreased margins from Medicare and Medicaid and lower reimbursement from consolidating insurers. The objectives of this study are to determine whether hospitals that became more profitable increased revenues or decreased costs more and to examine characteristics associated with improved financial performance over time. The design of this study is retrospective analyses of U.S. non-federal acute care hospitals between 2003 and 2013. There are 2824 hospitals as subjects of this study. The main measures of this study are the change in clinical operating margin, change in revenues per bed, and change in expenses per bed between 2003 and 2013. Hospitals that became more profitable had a larger magnitude of increases in revenue per bed (about $113,000 per year [95% confidence interval: $93,132 to $133,401]) than of decreases in costs per bed (about - $10,000 per year [95% confidence interval: - $28,956 to $9617]), largely driven by higher non-Medicare reimbursement. Hospitals that improved their margins were larger or joined a hospital system. Not-for-profit status was associated with increases in operating margin, while rural status and having a larger share of Medicare patients were associated with decreases in operating margin. There was no association between improved hospital profitability and changes in diagnosis related group weight, in number of profitable services, or in payer mix. Hospitals that became more profitable were more likely to increase their admissions per bed per year. Differential price increases have led to improved margins for some hospitals over time. Where significant price increases are not possible, hospitals will have to become more efficient to maintain profitability.

Arthroscopic Debridement for Primary Degenerative Osteoarthritis of the Elbow Leads to Significant Improvement in Range of Motion and Clinical Outcomes: A Systematic Review.

PubMed

Sochacki, Kyle R; Jack, Robert A; Hirase, Takashi; McCulloch, Patrick C; Lintner, David M; Liberman, Shari R; Harris, Joshua D

2017-12-01

The purpose of this investigation was to determine whether arthroscopic debridement of primary elbow osteoarthritis results in statistically significant and clinically relevant improvement in (1) elbow range of motion and (2) clinical outcomes with (3) low complication and reoperation rates. A systematic review was registered with PROSPERO and performed using PRISMA guidelines. Databases were searched for studies that investigated the outcomes of arthroscopic debridement for the treatment of primary osteoarthritis of the elbow in adult human patients. Study methodological quality was analyzed. Studies that included post-traumatic arthritis were excluded. Elbow motion and all elbow-specific patient-reported outcome scores were eligible for analysis. Comparisons between preoperative and postoperative values from each study were made using 2-sample Z-tests (http://in-silico.net/tools/statistics/ztest) using a P value < .05. Nine articles (209 subjects, 213 elbows, 187 males, 22 females, mean age 45.7 ± 7.1 years, mean follow-up 41.7 ± 16.3. months; 75% right, 25% left; 79% dominant elbow, 21% nondominant) were analyzed. Elbow extension (23.4°-10.7°, Δ 12.7°), flexion (115.9°-128.7°, Δ 12.8°), and global arc of motion (94.5°-117.6°, Δ 23.1°) had statistically significant and clinically relevant improvement following arthroscopic debridement (P < .0001 for all). There was also a statistically significant (P < .0001) and clinically relevant improvement in the Mayo Elbow Performance Score (60.7-84.6, Δ 23.9) postoperatively. Six patients (2.8%) had postoperative complications. Nine (4.2%) underwent reoperation. Elbow arthroscopic debridement for primary degenerative osteoarthritis results in statistically significant and clinically relevant improvement in elbow range of motion and clinical outcomes with low complication and reoperation rates. Systematic review of level IV studies. Copyright © 2017 Arthroscopy Association of North America. Published by

Improvement Rate of Acute Otitis Media Caused by Haemophilus influenzae at 1 Week Is Significantly Associated with Time to Recovery

PubMed Central

Yamazaki, Yoshitaka; Qin, Liang; Okitsu, Naohiro; Yahara, Koji; Irimada, Mihoko; Hirakata, Yoichi; Kaku, Mitsuo; Kobayashi, Toshimitsu; Watanabe, Hiroshi

2013-01-01

Acute otitis media (AOM) is the most common upper respiratory tract infection in childhood. Children with AOM were enrolled at Tohoku Rosai Hospital between July 2006 and June 2011 if their middle ear fluid cultures after tympanocentesis yielded only Haemophilus influenzae. The susceptibilities of the isolates to ampicillin were determined, and microtiter biofilm assays and invasion assays using BEAS-2B cells were performed. The association between these bacterial characteristics and clinical relapses of AOM and treatment failures was evaluated. Seventy-four children (39 boys and 35 girls) with a median age of 1 year (interquartile range [IQR], 0.25 to 2 years) were enrolled. Among 74 H. influenzae isolates, 37 showed intermediate resistance or resistance to ampicillin (MIC, ≥2 μg/ml). In the microtiter biofilm assay, the median optical density at 600 nm (OD600) was 0.68 (IQR, 0.24 to 1.02), and 70 isolates formed biofilms. The median invasion rate was 15% (IQR, 0 to 10%), and 46 isolates invaded BEAS-2B cells. Relapses and treatment failures occurred in 19 and 6 children, respectively. There was no significant difference in the invasion rates between patients with and those without relapses or treatment failures. Also, there was no significant association between biofilm formation and relapse or treatment failure. The improvements in the severity scores after 1 week were significantly associated with the recovery time (P < 0.0001). We did not identify any significant association between relapse or treatment failure and bacterial factors. AOM has a multifactorial etiology, and this may explain why we could not find a significant association. An improvement in the severity score after 1 week of treatment may be a useful predictor of the outcome of AOM. PMID:23966504

Improvement of vertical velocity statistics measured by a Doppler lidar through comparison with sonic anemometer observations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bonin, Timothy A.; Newman, Jennifer F.; Klein, Petra M.

Since turbulence measurements from Doppler lidars are being increasingly used within wind energy and boundary-layer meteorology, it is important to assess and improve the accuracy of these observations. While turbulent quantities are measured by Doppler lidars in several different ways, the simplest and most frequently used statistic is vertical velocity variance ( w' 2) from zenith stares. However, the competing effects of signal noise and resolution volume limitations, which respectively increase and decrease w' 2, reduce the accuracy of these measurements. Herein, an established method that utilises the autocovariance of the signal to remove noise is evaluated and its skillmore » in correcting for volume-averaging effects in the calculation of w' 2 is also assessed. Additionally, this autocovariance technique is further refined by defining the amount of lag time to use for the most accurate estimates of w' 2. Through comparison of observations from two Doppler lidars and sonic anemometers on a 300 m tower, the autocovariance technique is shown to generally improve estimates of w' 2. After the autocovariance technique is applied, values of w' 2 from the Doppler lidars are generally in close agreement ( R 2≈0.95-0.98) with those calculated from sonic anemometer measurements.« less

Improvement of vertical velocity statistics measured by a Doppler lidar through comparison with sonic anemometer observations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bonin, Timothy A.; Newman, Jennifer F.; Klein, Petra M.

Since turbulence measurements from Doppler lidars are being increasingly used within wind energy and boundary-layer meteorology, it is important to assess and improve the accuracy of these observations. While turbulent quantities are measured by Doppler lidars in several different ways, the simplest and most frequently used statistic is vertical velocity variance ( w' 2) from zenith stares. But, the competing effects of signal noise and resolution volume limitations, which respectively increase and decrease w' 2, reduce the accuracy of these measurements. Herein, an established method that utilises the autocovariance of the signal to remove noise is evaluated and its skillmore » in correcting for volume-averaging effects in the calculation of w' 2 is also assessed. In addition, this autocovariance technique is further refined by defining the amount of lag time to use for the most accurate estimates of w' 2. And through comparison of observations from two Doppler lidars and sonic anemometers on a 300 m tower, the autocovariance technique is shown to generally improve estimates of w' 2. After the autocovariance technique is applied, values of w' 2 from the Doppler lidars are generally in close agreement ( R 2 ≈ 0.95 -0.98) with those calculated from sonic anemometer measurements.« less

Improvement of vertical velocity statistics measured by a Doppler lidar through comparison with sonic anemometer observations

DOE PAGES

Bonin, Timothy A.; Newman, Jennifer F.; Klein, Petra M.; ...

2016-12-06

Since turbulence measurements from Doppler lidars are being increasingly used within wind energy and boundary-layer meteorology, it is important to assess and improve the accuracy of these observations. While turbulent quantities are measured by Doppler lidars in several different ways, the simplest and most frequently used statistic is vertical velocity variance ( w' 2) from zenith stares. But, the competing effects of signal noise and resolution volume limitations, which respectively increase and decrease w' 2, reduce the accuracy of these measurements. Herein, an established method that utilises the autocovariance of the signal to remove noise is evaluated and its skillmore » in correcting for volume-averaging effects in the calculation of w' 2 is also assessed. In addition, this autocovariance technique is further refined by defining the amount of lag time to use for the most accurate estimates of w' 2. And through comparison of observations from two Doppler lidars and sonic anemometers on a 300 m tower, the autocovariance technique is shown to generally improve estimates of w' 2. After the autocovariance technique is applied, values of w' 2 from the Doppler lidars are generally in close agreement ( R 2 ≈ 0.95 -0.98) with those calculated from sonic anemometer measurements.« less

Significant Advances in the AIRS Science Team Version-6 Retrieval Algorithm

NASA Technical Reports Server (NTRS)

Susskind, Joel; Blaisdell, John; Iredell, Lena; Molnar, Gyula

2012-01-01

AIRS/AMSU is the state of the art infrared and microwave atmospheric sounding system flying aboard EOS Aqua. The Goddard DISC has analyzed AIRS/AMSU observations, covering the period September 2002 until the present, using the AIRS Science Team Version-S retrieval algorithm. These products have been used by many researchers to make significant advances in both climate and weather applications. The AIRS Science Team Version-6 Retrieval, which will become operation in mid-20l2, contains many significant theoretical and practical improvements compared to Version-5 which should further enhance the utility of AIRS products for both climate and weather applications. In particular, major changes have been made with regard to the algOrithms used to 1) derive surface skin temperature and surface spectral emissivity; 2) generate the initial state used to start the retrieval procedure; 3) compute Outgoing Longwave Radiation; and 4) determine Quality Control. This paper will describe these advances found in the AIRS Version-6 retrieval algorithm and demonstrate the improvement of AIRS Version-6 products compared to those obtained using Version-5,

Model Improvement by Assimilating Observations of Storm-Induced Coastal Change

NASA Astrophysics Data System (ADS)

Long, J. W.; Plant, N. G.; Sopkin, K.

2010-12-01

Discrete, large scale, meteorological events such as hurricanes can cause wide-spread destruction of coastal islands, habitats, and infrastructure. The effects can vary significantly along the coast depending on the configuration of the coastline, variable dune elevations, changes in geomorphology (sandy beach vs. marshland), and alongshore variations in storm hydrodynamic forcing. There are two primary methods of determining the changing state of a coastal system. Process-based numerical models provide highly resolved (in space and time) representations of the dominant dynamics in a physical system but must employ certain parameterizations due to computational limitations. The predictive capability may also suffer from the lack of reliable initial or boundary conditions. On the other hand, observations of coastal topography before and after the storm allow the direct quantification of cumulative storm impacts. Unfortunately these measurements suffer from instrument noise and a lack of necessary temporal resolution. This research focuses on the combination of these two pieces of information to make more reliable forecasts of storm-induced coastal change. Of primary importance is the development of a data assimilation strategy that is efficient, applicable for use with highly nonlinear models, and able to quantify the remaining forecast uncertainty based on the reliability of each individual piece of information used in the assimilation process. We concentrate on an event time-scale and estimate/update unobserved model information (boundary conditions, free parameters, etc.) by assimilating direct observations of coastal change with those simulated by the model. The data assimilation can help estimate spatially varying quantities (e.g. friction coefficients) that are often modeled as homogeneous and identify processes inadequately characterized in the model.

Observation of High School Students' Food Handling Behaviors: Do They Improve following a Food Safety Education Intervention?

PubMed

Diplock, Kenneth J; Dubin, Joel A; Leatherdale, Scott T; Hammond, David; Jones-Bitton, Andria; Majowicz, Shannon E

2018-06-01

Youth are a key audience for food safety education. They often engage in risky food handling behaviors, prepare food for others, and have limited experience and knowledge of safe food handling practices. Our goal was to investigate the effectiveness of an existing food handler training program for improving safe food handling behaviors among high school students in Ontario, Canada. However, because no schools agreed to provide control groups, we evaluated whether behaviors changed following delivery of the intervention program and whether changes were sustained over the school term. We measured 32 food safety behaviors, before the intervention and at 2-week and 3-month follow-up evaluations by in-person observations of students ( n = 119) enrolled in grade 10 and 12 Food and Nutrition classes ( n = 8) and who individually prepared recipes. We examined within-student changes in behaviors across the three time points, using mixed effects regression models to model trends in the total food handling score (of a possible 32 behaviors) and subscores for "clean" (17 behaviors), "separate" (14 behaviors), and "cook" (1 behavior), adjusting for student characteristics. At baseline, students ( n = 108) averaged 49.1% (15.7 of 32 behaviors; standard deviation = 5.8) correct food handling behaviors, and only 5.5% (6) of the 108 students used a food thermometer to check the doneness of the chicken (the "cook" behavior). All four behavior score types increased significantly ∼2 weeks postintervention and remained unchanged ∼3 months later. Student characteristics (e.g., having taken a prior food handling course) were not significant predictors of the total number of correctly performed food handling behaviors or of the "clean" or "separate" behaviors, working or volunteering in a food service establishment was the only characteristic significantly associated with food thermometer use (i.e., "cook"). Despite the significant increase in correct behaviors, students continued to

The Orientation of Gastric Biopsy Samples Improves the Inter-observer Agreement of the OLGA Staging System.

PubMed

Cotruta, Bogdan; Gheorghe, Cristian; Iacob, Razvan; Dumbrava, Mona; Radu, Cristina; Bancila, Ion; Becheanu, Gabriel

2017-12-01

Evaluation of severity and extension of gastric atrophy and intestinal metaplasia is recommended to identify subjects with a high risk for gastric cancer. The inter-observer agreement for the assessment of gastric atrophy is reported to be low. The aim of the study was to evaluate the inter-observer agreement for the assessment of severity and extension of gastric atrophy using oriented and unoriented gastric biopsy samples. Furthermore, the quality of biopsy specimens in oriented and unoriented samples was analyzed. A total of 35 subjects with dyspeptic symptoms addressed for gastrointestinal endoscopy that agreed to enter the study were prospectively enrolled. The OLGA/OLGIM gastric biopsies protocol was used. From each subject two sets of biopsies were obtained (four from the antrum, two oriented and two unoriented, two from the gastric incisure, one oriented and one unoriented, four from the gastric body, two oriented and two unoriented). The orientation of the biopsy samples was completed using nitrocellulose filters (Endokit®, BioOptica, Milan, Italy). The samples were blindly examined by two experienced pathologists. Inter-observer agreement was evaluated using kappa statistic for inter-rater agreement. The quality of histopathology specimens taking into account the identification of lamina propria was analyzed in oriented vs. unoriented samples. The samples with detectable lamina propria mucosae were defined as good quality specimens. Categorical data was analyzed using chi-square test and a two-sided p value <0.05 was considered statistically significant. A total of 350 biopsy samples were analyzed (175 oriented / 175 unoriented). The kappa index values for oriented/unoriented OLGA 0/I/II/III and IV stages have been 0.62/0.13, 0.70/0.20, 0.61/0.06, 0.62/0.46, and 0.77/0.50, respectively. For OLGIM 0/I/II/III stages the kappa index values for oriented/unoriented samples were 0.83/0.83, 0.88/0.89, 0.70/0.88 and 0.83/1, respectively. No case of OLGIM IV

Tropical cyclones-Pacific Asian Research Campaign for Improvement of Intensity estimations/forecasts (T-PARCII): A research plan of typhoon aircraft observations in Japan

NASA Astrophysics Data System (ADS)

Tsuboki, Kazuhisa

2017-04-01

Typhoons are the most devastating weather system occurring in the western North Pacific and the South China Sea. Violent wind and heavy rainfall associated with a typhoon cause huge disaster in East Asia including Japan. In 2013, Supertyphoon Haiyan struck the Philippines caused a very high storm surge and more than 7000 people were killed. In 2015, two typhoons approached the main islands of Japan and severe flood occurred in the northern Kanto region. Typhoons are still the largest cause of natural disaster in East Asia. Moreover, many researches have projected increase of typhoon intensity with the climate change. This suggests that a typhoon risk is increasing in East Asia. However, the historical data of typhoon include large uncertainty. In particular, intensity data of the most intense typhoon category have larger error after the US aircraft reconnaissance of typhoon was terminated in 1987.The main objective of the present study is improvements of typhoon intensity estimations and of forecasts of intensity and track. We will perform aircraft observation of typhoon and the observed data are assimilated to numerical models to improve intensity estimation. Using radars and balloons, observations of thermodynamical and cloud-microphysical processes of typhoons will be also performed to improve physical processes of numerical model. In typhoon seasons (mostly in August and September), we will perform aircraft observations of typhoons. Using dropsondes from the aircraft, temperature, humidity, pressure, and wind are measured in surroundings of the typhoon inner core region. The dropsonde data are assimilated to a cloud-resolving model which has been developed in Nagoya University and named the Cloud Resolving Storm Simulator (CReSS). Then, more accurate estimations and forecasts of the typhoon intensity will be made as well as typhoon tracks. Furthermore, we will utilize a ground-based balloon with microscope camera, X-band precipitation radar, Ka-band cloud radar

An improved Overhauser magnetometer for Earth's magnetic field observation

NASA Astrophysics Data System (ADS)

Fan, Shifang; Chen, Shudong; Zhang, Shuang; Guo, Xin; Cao, Qiong

2016-09-01

Overhauser magnetometer is a kind of high-precision devices for magnetostatic field measurement. It is widely used in geological survey, earth field variations, UXO detection etc. However, the original Overhauser magnetometer JOM-2 shows great shortcomings of low signal to noise ratio (SNR) and high power consumption, which directly affect the performance of the device. In order to increase the sensitivity and reduce power consumption, we present an improved Overhauser magnetometer. Firstly, compared with the original power board which suffers from heavy noise for improper EMC design, an improved power broad with 20mV peak to peak noise is presented in this paper. Then, the junction field effect transistor (JFET) is used as pre-amplifier in our new design, to overcome the higher current noise produced by the original instrumentation amplifier. By adjusting the parameters carefully low noise factor down to 0.5 dB can be obtained. Finally, the new architecture of ARM + CPLD is adopted to replace the original one with DSP+CPLD. So lower power consumption and greater flash memory can be realized. With these measures, an improved Overhauser magnetometer with higher sensitivity and lower power consumption is design here. The experimental results indicate that the sensitivity of the improved Overhauser magnetometer is 0.071nT, which confirms that the new magnetometer is sensitive to earth field measurement.

Kalman filter data assimilation: targeting observations and parameter estimation.

PubMed

Bellsky, Thomas; Kostelich, Eric J; Mahalov, Alex

2014-06-01

This paper studies the effect of targeted observations on state and parameter estimates determined with Kalman filter data assimilation (DA) techniques. We first provide an analytical result demonstrating that targeting observations within the Kalman filter for a linear model can significantly reduce state estimation error as opposed to fixed or randomly located observations. We next conduct observing system simulation experiments for a chaotic model of meteorological interest, where we demonstrate that the local ensemble transform Kalman filter (LETKF) with targeted observations based on largest ensemble variance is skillful in providing more accurate state estimates than the LETKF with randomly located observations. Additionally, we find that a hybrid ensemble Kalman filter parameter estimation method accurately updates model parameters within the targeted observation context to further improve state estimation.

Structuralized box-trainer laparoscopic training significantly improves performance in complex virtual reality laparoscopic tasks.

PubMed

Laski, Dariusz; Stefaniak, Tomasz J; Makarewicz, Wojciech; Proczko, Monika; Gruca, Zbigniew; Sledziński, Zbigniew

2012-03-01

In the era of flowering minimally invasive surgical techniques there is a need for new methods of teaching surgery and supervision of progress in skills and expertise. Virtual and physical box-trainers seem especially fit for this purpose, and allow for improvement of proficiency required in laparoscopic surgery. The study included 34 students who completed the authors' laparoscopic training on physical train-boxes. Progress was monitored by accomplishment of 3 exercises: moving pellets from one place to another, excising and clipping. Analysed parameters included time needed to complete the exercise and right and left hand movement tracks. Students were asked to do assigned tasks prior to, in the middle and after the training. The duration of the course was 28 h in total. Significant shortening of the time to perform each exercise and reduction of the left hand track were achieved. The right hand track was shortened only in exercise number 1. Exercises in the laboratory setting should be regarded as an important element of the process of skills acquisition by a young surgeon. Virtual reality laparoscopic training seems to be a new, interesting educational tool, and at the same time allows for reliable control and assessment of progress.

Perceptual Learning Improves Stereoacuity in Amblyopia

PubMed Central

Xi, Jie; Jia, Wu-Li; Feng, Li-Xia; Lu, Zhong-Lin; Huang, Chang-Bing

2014-01-01

Purpose. Amblyopia is a developmental disorder that results in both monocular and binocular deficits. Although traditional treatment in clinical practice (i.e., refractive correction, or occlusion by patching and penalization of the fellow eye) is effective in restoring monocular visual acuity, there is little information on how binocular function, especially stereopsis, responds to traditional amblyopia treatment. We aim to evaluate the effects of perceptual learning on stereopsis in observers with amblyopia in the current study. Methods. Eleven observers (21.1 ± 5.1 years, six females) with anisometropic or ametropic amblyopia were trained to judge depth in 10 to 13 sessions. Red–green glasses were used to present three different texture anaglyphs with different disparities but a fixed exposure duration. Stereoacuity was assessed with the Fly Stereo Acuity Test and visual acuity was assessed with the Chinese Tumbling E Chart before and after training. Results. Averaged across observers, training significantly reduced disparity threshold from 776.7″ to 490.4″ (P < 0.01) and improved stereoacuity from 200.3″ to 81.6″ (P < 0.01). Interestingly, visual acuity also significantly improved from 0.44 to 0.35 logMAR (approximately 0.9 lines, P < 0.05) in the amblyopic eye after training. Moreover, the learning effects in two of the three retested observers were largely retained over a 5-month period. Conclusions. Perceptual learning is effective in improving stereo vision in observers with amblyopia. These results, together with previous evidence, suggest that structured monocular and binocular training might be necessary to fully recover degraded visual functions in amblyopia. Chinese Abstract PMID:24508791

Intraoperative Sensorcaine significantly improves postoperative pain management in outpatient reduction mammaplasty.

PubMed

Culliford, Alfred T; Spector, Jason A; Flores, Roberto L; Louie, Otway; Choi, Mihye; Karp, Nolan S

2007-09-15

Breast reduction is one of the most frequently performed plastic surgical procedures in the United States; more than 160,500 patients underwent the procedure in 2005. Many outpatient reduction mammaplasty patients report the greatest postoperative discomfort in the first 48 hours. The authors' investigated the effect of intraoperative topical application of the long-acting local anesthetic agent bupivacaine (Sensorcaine or Marcaine) on postoperative pain, time to postanesthesia care unit discharge, and postoperative use of narcotic medication. In a prospective, randomized, single-blind trial, intraoperative use of Sensorcaine versus placebo (normal saline) was compared. Postoperative pain was quantified using the visual analogue scale, and time to discharge from the postanesthesia care unit was recorded. Patients documented their outpatient pain medication usage. Of the 37 patients enrolled in the study, 20 were treated with intraoperative topical Sensorcaine and 17 received placebo. Patients treated with Sensorcaine were discharged home significantly faster (2.9 hours versus 3.8 hours, p = 0.002). The control arm consistently had higher pain scores in the postanesthesia care unit (although not statistically significant) than the Sensorcaine group using the visual analogue scale system. Furthermore, patients receiving Sensorcaine required significantly less narcotic medication while recovering at home (mean, 3.5 tablets of Vicodin) than the control group (mean, 6.4 tablets; p = 0.001). There were no complications resulting from Sensorcaine usage. This prospective, randomized, single-blind study demonstrates that a single dose of intraoperative Sensorcaine provides a safe, inexpensive, and efficacious way to significantly shorten the length of postanesthesia care unit stay and significantly decrease postoperative opioid analgesic use in patients undergoing ambulatory reduction mammaplasty.

Longwave infrared observation of urban landscapes

NASA Technical Reports Server (NTRS)

Goward, S. N.

1981-01-01

An investigation is conducted regarding the feasibility to develop improved methods for the identification and analysis of urban landscapes on the basis of a utilization of longwave infrared observations. Attention is given to landscape thermal behavior, urban thermal properties, modeled thermal behavior of pavements and buildings, and observed urban landscape thermal emissions. The differential thermal behavior of buildings, pavements, and natural areas within urban landscapes is found to suggest that integrated multispectral solar radiant reflectance and terrestrial radiant emissions data will significantly increase potentials for analyzing urban landscapes. In particular, daytime satellite observations of the considered type should permit better identification of urban areas and an analysis of the density of buildings and pavements within urban areas. This capability should enhance the utility of satellite remote sensor data in urban applications.

Direct microscopic observation of forward osmosis membrane fouling.

PubMed

Wang, Yining; Wicaksana, Filicia; Tang, Chuyang Y; Fane, Anthony G

2010-09-15

This study describes the application of a noninvasive direct microscopic observation method for characterizing fouling of a forward osmosis (FO) membrane. The effect of the draw solution concentration, membrane orientation, and feed spacer on FO fouling was systematically investigated in a cross-flow setup using latex particles as model foulant in the feedwater. Higher draw solution (DS) concentrations (and thus increased flux levels) resulted in dramatic increase in the surface coverage by latex particles, suggesting that the critical flux concept might be applicable even for the osmotically driven FO process. Under identical draw solution concentrations, the active-layer-facing-the-feed-solution orientation (AL-FS) experienced significantly less fouling compared to the alternative orientation. This may be explained by the lower water flux in AL-FS, which is consistent with the critical flux concept. The use of a feed spacer not only dramatically enhanced the initial flux of the FO membrane, but also significantly improved the flux stability during FO fouling. Despite such beneficial effects of using the feed spacer, a significant amount of particle accumulation was found near the spacer filament, suggesting further opportunities for improved spacer design. To the best of the authors' knowledge, this is the first direct microscopic observation study on FO fouling.

[Changes observed in three quality indicators after the implementation of improvement strategies in the respiratory intensive care unit].

PubMed

Álvarez Maldonado, Pablo; Cueto Robledo, Guillermo; Cicero Sabido, Raúl

2015-04-01

To compare the results of quality monitoring after the implementation of improvement strategies in the respiratory intensive care unit (RICU). A prospective, comparative, longitudinal and interventional study was carried out. The RICU of Hospital General de México (Mexico). All patients admitted to the RICU from March 2012 to March 2013. An evidence-based bundle of interventions was implemented in order to reduce the ratios of three quality indicators: non-planned extubation (NPE), reintubation, and ventilator-associated pneumonia (VAP). NPE, reintubation and VAP ratios. A total of 232 patients were admitted, with a mean age of 49.5±17.8years; 119 (50.5%) were woman. The mean Simplified Acute Physiology Score (SAPS-3) was 49.8±17, and the mean Sequential Organ Failure Assessment (SOFA) score was 5.3±4.1. The mortality rate in the RICU was 38.7%. The standardized mortality ratio was 1.50 (95%CI: 1.20-1.84). An improved ratio was observed for reintubation and NPE indicators compared to the ratios of the previous 2011 cohort: 1.6% vs. 7% (P=.02) and 8.1 vs. 17 episodes per 1000 days of mechanical ventilation (P=.04), respectively. A worsened VAP ratio was observed: 18.4 vs. 15.1 episodes per 1000 days of mechanical ventilation (P=.5). Quality improvement is feasible with the identification of areas of opportunity and the implementation of strategies. Nevertheless, the implementation of a bundle of preventive measures in itself does not guarantee improvements. Copyright © 2013 Elsevier España, S.L.U. and SEMICYUC. All rights reserved.

High-intensity interval training (swimming) significantly improves the adverse metabolism and comorbidities in diet-induced obese mice.

PubMed

Motta, Victor F; Aguila, Marcia B; Mandarim-DE-Lacerda, Carlos A

2016-05-01

Controlling obesity and other comorbidities in the population is a challenge in modern society. High-intensity interval training (HIIT) combines short periods of high-intensity exercise with long recovery periods or a low-intensity exercise. The aim was to assess the impact of HIIT in the context of diet-induced obesity in the animal model. C57BL/6 mice were fed one of the two diets: standard chow (lean group [LE]) or a high-fat diet (obese group [OB]). After twelve weeks, the animals were divided into non-trained groups (LE-NT and OB-NT) and trained groups (LE-T and OB-T), and began an exercise protocol. For biochemical analysis of inflammatory and lipid profile, we used a colorimetric enzymatic method and an automatic spectrophotometer. One-way ANOVA was used for statistical analysis of the experimental groups with Holm-Sidak post-hoc Test. Two-way ANOVA analyzed the interactions between diet and HIIT protocol. HIIT leads to significant reductions in body mass, blood glucose, glucose tolerance and hepatic lipid profile in T-groups compared to NT-groups. HIIT was able to reduce plasma levels of inflammatory cytokines. Additionally, HIIT improves the insulin immunodensity in the islets, reduces the adiposity and the hepatic steatosis in the T-groups. HIIT improves beta-oxidation and peroxisome proliferator-activated receptor (PPAR)-alpha and reduces lipogenesis and PPAR-gamma levels in the liver. In skeletal muscle, HIIT improves PPAR-alpha and glucose transporter-4 and reduces PPAR-gamma levels. HIIT leads to attenuate the adverse effects caused by a chronic ingestion of a high-fat diet.

High-intensity interval training (swimming) significantly improves the adverse metabolism and comorbidities in diet-induced obese mice.

PubMed

Motta, V F; Aguila, M B; Mandarim-De-Lacerda, C A

2015-02-10

Controlling obesity and other comorbidities in the population is a challenge in modern society. High-intensity interval training (HIIT) combines short periods of high-intensity exercise with long recovery periods or a low-intensity exercise. The aim was to assess the impact of HIIT in the context of diet-induced obesity in the animal model. C57BL/6 mice were fed one of the two diets: standard chow (Lean group - LE) or a high--fat diet (Obese group - OB). After twelve weeks, the animals were divided into non-trained groups (LE--NT and OB-NT) and trained groups (LE-T and OB--T), and began an exercise protocol. For biochemical analysis of inflammatory and lipid profile, we used a colorimetric enzymatic method and an automatic spectrophotometer. One-way ANOVA was used for statistical analysis of the experimental groups with Holm-Sidak pos hoc test. Two-way ANOVA analyzed the interactions between diet and HIIT protocol. HIIT leads to significant reductions in body mass, blood glucose, glucose tolerance and hepatic lipid profile in T-groups compared to NT-groups. HIIT was able to reduce plasma levels of inflammatory cytokines. Additionally, HIIT improves the insulin immunodensity in the islets, reduces the adiposity and the hepatic steatosis in the T-groups. HIIT improves beta--oxidation and peroxisome proliferator--activated receptor (PPAR)-alpha and reduces lipogenesis and PPAR--gamma levels in the liver. In skeletal muscle, HIIT improves PPAR--alpha and glucose transporter-4 and reduces PPAR--gamma levels. HIIT leads to attenuate the adverse effects caused by a chronic ingestion of a high-fat diet.

Significant Variation of Post-critical SsPmp Amplitude as a Result of Variation in Near-surface Velocity: Observations from the Yellowknife Array

NASA Astrophysics Data System (ADS)

Ferragut, G.; Liu, T.; Klemperer, S. L.

2017-12-01

In recent years Virtual Deep Seismic Sounding (VDSS) emerged as a novel method to image the Moho, which uses the post-critical reflection P waves at the Moho generated by teleseismic S waves at the free surface near the receivers (SsPmp). However, observed SsPmp sometimes have significantly lower amplitude than predicted, raising doubts among the seismic community on the theoretical basis of the method. With over two decades of continuous digital broadband records and major subduction zones in the range of 30-50 degrees, the Yellowknife Array in northern Canada provides a rich opportunity for observation of post-critical SsPmp. We analyze S wave coda of events with epicenter distances of 30-50°, and pay special attention to earthquakes in a narrow azimuth range that ­­­encompasses the Kamchatka Peninsula. Among 21 events with strong direct S energy on the radial components, we observe significant variation of SsPmp energy. After associating the SsPmp energy with the virtual source location of each event, we observe a general trend of decreasing SsPmp energy from NE to SW. As the trend coincides with the transition from exposed basement of the Slave Craton to Paleozoic platform covered by Phanerozoic sediment, we interpret the decreasing SsPmp energy as a result of lower S velocity at the virtual sources, which reduces S-to-P reflection coefficients. We plan to include more events from the Aleutian Islands, the virtual sources of which are primarily located in the Paleozoic platform. This will allow us to further investigate the relationship between SsPmp amplitude and near-surface velocity.

Acid or erythromycin stress significantly improves transformation efficiency through regulating expression of DNA binding proteins in Lactococcus lactis F44.

PubMed

Wang, Binbin; Zhang, Huawei; Liang, Dongmei; Hao, Panlong; Li, Yanni; Qiao, Jianjun

2017-12-01

Lactococcus lactis is a gram-positive bacterium used extensively in the dairy industry and food fermentation, and its biological characteristics are usually improved through genetic manipulation. However, poor transformation efficiency was the main restriction factor for the construction of engineered strains. In this study, the transformation efficiency of L. lactis F44 showed a 56.1-fold increase in acid condition (pH 5.0); meanwhile, erythromycin stress (0.04 μg/mL) promoted the transformation efficiency more significantly (76.9-fold). Notably, the transformation efficiency of F44e (L. lactis F44 harboring empty pLEB124) increased up to 149.1-fold under the synergistic stresses of acid and erythromycin. In addition, the gene expression of some DNA binding proteins (DprA, RadA, RadC, RecA, RecQ, and SsbA) changed correspondingly. Especially for radA, 25.1-fold improvement was detected when F44e was exposed to pH 5.0. Overexpression of some DNA binding proteins could improve the transformation efficiency. The results suggested that acid or erythromycin stress could improve the transformation efficiency of L. lactis through regulating gene expression of DNA binding proteins. We have proposed a simple but promising strategy for improving the transformation efficiency of L. lactis and other hard-transformed microorganisms. Copyright © 2017 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Co-overexpressing a Plasma Membrane and a Vacuolar Membrane Sodium/Proton Antiporter Significantly Improves Salt Tolerance in Transgenic Arabidopsis Plants

PubMed Central

Pehlivan, Necla; Sun, Li; Jarrett, Philip; Yang, Xiaojie; Mishra, Neelam; Chen, Lin; Kadioglu, Asim; Shen, Guoxin; Zhang, Hong

2016-01-01

The Arabidopsis gene AtNHX1 encodes a vacuolar membrane-bound sodium/proton (Na+/H+) antiporter that transports Na+ into the vacuole and exports H+ into the cytoplasm. The Arabidopsis gene SOS1 encodes a plasma membrane-bound Na+/H+ antiporter that exports Na+ to the extracellular space and imports H+ into the plant cell. Plants rely on these enzymes either to keep Na+ out of the cell or to sequester Na+ into vacuoles to avoid the toxic level of Na+ in the cytoplasm. Overexpression of AtNHX1 or SOS1 could improve salt tolerance in transgenic plants, but the improved salt tolerance is limited. NaCl at concentration >200 mM would kill AtNHX1-overexpressing or SOS1-overexpressing plants. Here it is shown that co-overexpressing AtNHX1 and SOS1 could further improve salt tolerance in transgenic Arabidopsis plants, making transgenic Arabidopsis able to tolerate up to 250 mM NaCl treatment. Furthermore, co-overexpression of AtNHX1 and SOS1 could significantly reduce yield loss caused by the combined stresses of heat and salt, confirming the hypothesis that stacked overexpression of two genes could substantially improve tolerance against multiple stresses. This research serves as a proof of concept for improving salt tolerance in other plants including crops. PMID:26985021

Assimilating uncertain, dynamic and intermittent streamflow observations in hydrological models

NASA Astrophysics Data System (ADS)

Mazzoleni, Maurizio; Alfonso, Leonardo; Chacon-Hurtado, Juan; Solomatine, Dimitri

2015-09-01

Catastrophic floods cause significant socio-economical losses. Non-structural measures, such as real-time flood forecasting, can potentially reduce flood risk. To this end, data assimilation methods have been used to improve flood forecasts by integrating static ground observations, and in some cases also remote sensing observations, within water models. Current hydrologic and hydraulic research works consider assimilation of observations coming from traditional, static sensors. At the same time, low-cost, mobile sensors and mobile communication devices are becoming also increasingly available. The main goal and innovation of this study is to demonstrate the usefulness of assimilating uncertain streamflow observations that are dynamic in space and intermittent in time in the context of two different semi-distributed hydrological model structures. The developed method is applied to the Brue basin, where the dynamic observations are imitated by the synthetic observations of discharge. The results of this study show how model structures and sensors locations affect in different ways the assimilation of streamflow observations. In addition, it proves how assimilation of such uncertain observations from dynamic sensors can provide model improvements similar to those of streamflow observations coming from a non-optimal network of static physical sensors. This can be a potential application of recent efforts to build citizen observatories of water, which can make the citizens an active part in information capturing, evaluation and communication, helping simultaneously to improvement of model-based flood forecasting.

Low Dose Vaporized Cannabis Significantly Improves Neuropathic Pain

PubMed Central

Wilsey, Barth; Marcotte, Thomas D.; Deutsch, Reena; Gouaux, Ben; Sakai, Staci; Donaghe, Haylee

2013-01-01

We conducted a double-blind, placebo-controlled, crossover study evaluating the analgesic efficacy of vaporized cannabis in subjects, the majority of whom were experiencing neuropathic pain despite traditional treatment. Thirty-nine patients with central and peripheral neuropathic pain underwent a standardized procedure for inhaling either medium dose (3.53%), low dose (1.29%), or placebo cannabis with the primary outcome being VAS pain intensity. Psychoactive side-effects, and neuropsychological performance were also evaluated. Mixed effects regression models demonstrated an analgesic response to vaporized cannabis. There was no significant difference between the two active dose groups’ results (p>0.7). The number needed to treat (NNT) to achieve 30% pain reduction was 3.2 for placebo vs. low dose, 2.9 for placebo vs. medium dose, and 25 for medium vs. low dose. As these NNT are comparable to those of traditional neuropathic pain medications, cannabis has analgesic efficacy with the low dose being, for all intents and purposes, as effective a pain reliever as the medium dose. Psychoactive effects were minimal and well-tolerated, and neuropsychological effects were of limited duration and readily reversible within 1–2 hours. Vaporized cannabis, even at low doses, may present an effective option for patients with treatment-resistant neuropathic pain. PMID:23237736

Towards Improved Understanding of Drought and Drought Impacts from Long Term Earth Observation Records

NASA Astrophysics Data System (ADS)

Champagne, C.; Wang, S.; Liu, J.; Hadwen, T. A.

2017-12-01

Drought is a complex natural disaster, which often emerges slowly, but can occur at various time scales and have impacts that are not well understood. Long term observations of drought intensity and frequency are often quantified from precipitation and temperature based indices or modelled estimates of soil water storage. The maturity of satellite based observations has created the potential to enhance the understanding of drought and drought impacts, particularly in regions where traditional data sets are limited by remoteness or inaccessibility, and where drought processes are not well-quantified by models. Long term global satellite data records now provide observations of key hydrological variables, including evaporation modelled from thermal sensors, soil moisture from microwave sensors, ground water from gravity sensors and vegetation condition that can be modelled from optical sensors. This study examined trends in drought frequency, intensity and duration over diverse ecoregions in Canada, including agricultural, grassland, forested and wetland areas. Trends in drought were obtained from the Canadian Drought Monitor as well as meteorological based indices from weather stations, and evaluated against satellite derived information on evaporative stress (Anderson et al. 2011), soil moisture (Champagne et al. 2015), terrestrial water storage (Wang and Li 2016) and vegetation condition (Davidson et al. 2009). Data sets were evaluated to determine differences in how different sensors characterize the hydrology and impacts of drought events from 2003 to 2016. Preliminary results show how different hydrological observations can provide unique information that can tie causes of drought (water shortages resulting from precipitation, lack of moisture storage or evaporative stress) to impacts (vegetation condition) that hold the potential to improve the understanding and classification of drought events.

A Smartphone Application Significantly Improved Diabetes Self-Care Activities with High User Satisfaction

PubMed Central

Kim, Yu Jin; Byun, Jong Kyu; Park, So Young; Hong, Soo Min; Chin, Sang Ouk; Chon, Suk; Oh, Seungjoon; Woo, Jeong-taek; Kim, Sung Woon; Kim, Young Seol

2015-01-01

Background We developed for the first time a smartphone application designed for diabetes self-management in Korea and registered a patent for the relevant algorithm. We also investigated the user satisfaction with the application and the change in diabetes related self-care activities after using the application. Methods We conducted a questionnaire survey on volunteers with diabetes who were using the application. Ninety subjects responded to the questionnaire between June 2012 and March 2013. A modified version of the Summary of Diabetes Self-Care Activities (SDSCA) was used in this study. Results The survey results exhibited a mean subject age of 44.0 years old, and males accounted for 78.9% of the subjects. Fifty percent of the subjects had diabetes for less than 3 years. The majority of respondents experienced positive changes in their clinical course after using the application (83.1%) and were satisfied with the structure and completeness of the application (86.7%). Additionally, the respondents' answers indicated that the application was easy to use (96.7%) and recommendable to others (97.7%) and that they would continue using the application to manage their diabetes (96.7%). After using the Diabetes Notepad application, diabetes related self-care activities assessed by SDSCA displayed statistically significant improvements (P<0.05), except for the number of days of drinking. Conclusion This smartphone-based application can be a useful tool leading to positive changes in diabetes related self-care activities and increase user satisfaction. PMID:26124991

[Observation on therapeutic effect of moxibustion with thunder-fire herbal moxa stick on xerophthalmia of oligodacrya].

PubMed

Chen, Lu-Quan

2008-08-01

To observe clinical therapeutic effect of moxibustion with thunder-fire herbal moxa stick on xerophthalmia of oligodacrya. Seventy cases were randomly divided into an observation group and a control group. The observation group (n=36) were treated with moxibustion with thunder-fire herbal moxa stick at Cuanzhu (BL 2), Yuyao (EX-HN 4), Tongziliao (GB 1), Taiyang (EX-HN 5), Sibai (ST 2), Jingming (BL 1), etc. and massage of acupoints and lacrimal gland around the eye. The control group (n=34) were treated with local dripping Leiran Diyanye. Changes of the main symptoms, tears secretion test, lacrimal membrane breaking time and corneal fluorescent staining before and after treatment were observed in the two groups. After treatment, sensation of dryness and foreign body sensation in the eye, asthenopia and gross symptoms significantly improved (P<0.01) in the two groups, and the observation group in the improvement of the sensation of dryness and foreign body sensation in the eye and the gross symptoms was better than the control group (P<0.05); tears secretion test significantly improved and was better in the observation group than that in the control group (P<0.05); lacrimal membrane breaking time and corneal fluorescent staining were improved in the two groups (P<0.05), and the improvement of lacrimal membrane breaking time in the observation group was more obvious than that in the control group (P<0.05). Moxibustion with thunder-fire herbal moxa stick has good therapeutic effect on xerophthalmia of oligodacrya.

Impact of Targeted Ocean Observations for Improving Ocean Model Initialization for Coupled Hurricane Forecasting

NASA Astrophysics Data System (ADS)

Halliwell, G. R.; Srinivasan, A.; Kourafalou, V. H.; Yang, H.; Le Henaff, M.; Atlas, R. M.

2012-12-01

The accuracy of hurricane intensity forecasts produced by coupled forecast models is influenced by errors and biases in SST forecasts produced by the ocean model component and the resulting impact on the enthalpy flux from ocean to atmosphere that powers the storm. Errors and biases in fields used to initialize the ocean model seriously degrade SST forecast accuracy. One strategy for improving ocean model initialization is to design a targeted observing program using airplanes and in-situ devices such as floats and drifters so that assimilation of the additional data substantially reduces errors in the ocean analysis system that provides the initial fields. Given the complexity and expense of obtaining these additional observations, observing system design methods such as OSSEs are attractive for designing efficient observing strategies. A new fraternal-twin ocean OSSE system based on the HYbrid Coordinate Ocean Model (HYCOM) is used to assess the impact of targeted ocean profiles observed by hurricane research aircraft, and also by in-situ float and drifter deployments, on reducing errors in initial ocean fields. A 0.04-degree HYCOM simulation of the Gulf of Mexico is evaluated as the nature run by determining that important ocean circulation features such as the Loop Current and synoptic cyclones and anticyclones are realistically simulated. The data-assimilation system is run on a 0.08-degree HYCOM mesh with substantially different model configuration than the nature run, and it uses a new ENsemble Kalman Filter (ENKF) algorithm optimized for the ocean model's hybrid vertical coordinates. The OSSE system is evaluated and calibrated by first running Observing System Experiments (OSEs) to evaluate existing observing systems, specifically quantifying the impact of assimilating more than one satellite altimeter, and also the impact of assimilating targeted ocean profiles taken by the NOAA WP-3D hurricane research aircraft in the Gulf of Mexico during the Deepwater

Improvement of vertical velocity statistics measured by a Doppler lidar through comparison with sonic anemometer observations

NASA Astrophysics Data System (ADS)

Bonin, Timothy A.; Newman, Jennifer F.; Klein, Petra M.; Chilson, Phillip B.; Wharton, Sonia

2016-12-01

Since turbulence measurements from Doppler lidars are being increasingly used within wind energy and boundary-layer meteorology, it is important to assess and improve the accuracy of these observations. While turbulent quantities are measured by Doppler lidars in several different ways, the simplest and most frequently used statistic is vertical velocity variance (w'2) from zenith stares. However, the competing effects of signal noise and resolution volume limitations, which respectively increase and decrease w'2, reduce the accuracy of these measurements. Herein, an established method that utilises the autocovariance of the signal to remove noise is evaluated and its skill in correcting for volume-averaging effects in the calculation of w'2 is also assessed. Additionally, this autocovariance technique is further refined by defining the amount of lag time to use for the most accurate estimates of w'2. Through comparison of observations from two Doppler lidars and sonic anemometers on a 300 m tower, the autocovariance technique is shown to generally improve estimates of w'2. After the autocovariance technique is applied, values of w'2 from the Doppler lidars are generally in close agreement (R2 ≈ 0.95 - 0.98) with those calculated from sonic anemometer measurements.

Air-insufflated high-definition dacryoendoscopy yields significantly better image quality than conventional dacryoendoscopy.

PubMed

Sasaki, Tsugihisa; Sounou, Tsutomu; Tsuji, Hideki; Sugiyama, Kazuhisa

2017-01-01

To facilitate the analysis of lacrimal conditions, we utilized high-definition dacryoendoscopy (HDD) and undertook observations with a pressure-controlled air-insufflation system. We report the safety and performance of HDD. In this retrospective, non-randomized clinical trial, 46 patients (14 males and 32 females; age range 39-91 years; mean age ± SD 70.3±12.0 years) who had lacrimal disorders were examined with HDD and conventional dacryoendoscopy (CD). The high-definition dacryoendoscope had 15,000 picture element image fibers and an advanced objective lens. Its outer diameter was 0.9-1.2 mm. Air insufflation was controlled at 0-20 kPa with a digital manometer-based pressure-controlled air-insufflation system to evaluate the quality of the image. The HDD had an air/saline irrigation channel between the outer sheath (outer diameter =1.2 mm) and the metal inner sheath of the endoscope. We used it and the CD in air, saline, and diluted milk saline with and without manual irrigation to quantitatively evaluate the effect of air pressure and saline irrigation on image quality. In vivo, the most significant improvement in image quality was demonstrated with air-insufflated (5-15 kPa) HDD, as compared with saline-irrigated HDD and saline-irrigated CD. No emphysema or damage was noted under observation with HDD. In vitro, no significant difference was demonstrated between air-insufflated HDD and saline-irrigated HDD. In vitro, the image quality of air-insufflated HDD was significantly improved as compared with that of saline-irrigated CD. Pressure-controlled (5-15 kPa) air-insufflated HDD is safe, and yields significantly better image quality than CD and saline-irrigated HDD.

An improved electrothermal model for the ERBE nonscanning radiometer - Comparison of predicted and measured behavior during solar observations

NASA Technical Reports Server (NTRS)

Tira, Nour E.; Mahan, J. R.; Lee, Robert B., III

1989-01-01

The improved Earth Radiation Budget Experiment nonscanning-channels electrothermal model presented is used to model two types of solar observations: those obtained through the solar port during solar calibration, and and those obtained during the satellite pitch-over maneuver, in which the sun is observed by the radiometer while it is in earth-viewing configuration. Thermal noise has been separately studied to evaluate its contribution to the radiative energy absorbed by the active cavity. It is found that the scattering of the collimated solar radiation contributes an average of 0.071 mW during solar calibration.

Atomic Layer Deposition Al2O3 Coatings Significantly Improve Thermal, Chemical, and Mechanical Stability of Anodic TiO2 Nanotube Layers

PubMed Central

2017-01-01

We report on a very significant enhancement of the thermal, chemical, and mechanical stability of self-organized TiO2 nanotubes layers, provided by thin Al2O3 coatings of different thicknesses prepared by atomic layer deposition (ALD). TiO2 nanotube layers coated with Al2O3 coatings exhibit significantly improved thermal stability as illustrated by the preservation of the nanotubular structure upon annealing treatment at high temperatures (870 °C). In addition, a high anatase content is preserved in the nanotube layers against expectation of the total rutile conversion at such a high temperature. Hardness of the resulting nanotube layers is investigated by nanoindentation measurements and shows strongly improved values compared to uncoated counterparts. Finally, it is demonstrated that Al2O3 coatings guarantee unprecedented chemical stability of TiO2 nanotube layers in harsh environments of concentrated H3PO4 solutions. PMID:28291942

Dual Assimilation of Microwave and Thermal-Infrared Satellite Observations of Soil Moisture into NLDAS for Improved Drought Monitoring

NASA Astrophysics Data System (ADS)

Hain, C.; Crow, W. T.; Anderson, M. C.; Zhan, X.; Wardlow, B.; Svoboda, M. D.; Mecikalski, J. R.

2011-12-01

Our research group is currently developing an operational data assimilation (DA) system for the optimal assimilation of thermal infrared (TIR) and microwave (MV) soil moisture (SM) and insertion of near real-time green vegetation fraction (GVF) into the Noah land-surface model component of the National Land Data Assimilation System (NLDAS). NLDAS produces the hydrologic products (e.g. soil moisture, evapotranspiration, and runoff) used by NCEP for operational drought monitoring, but these products are sensitive to model input errors in soil texture (affecting infiltration rates) and prescribed precipitation rates. Periodic updates of SM state variables in LSMs achieved by assimilating diagnostic moisture information retrieved using satellite remote sensing have been shown to compensate for model errors and result in improved hydrologic output. The work proposed here will build on a project currently funded under the Climate Test Bed Program entitled "A GOES Thermal-Based Drought Early Warning Index for NIDIS", which is developing an operational TIR SM index (Evaporative Stress Index; ESI) based on maps of the ratio of actual to potential ET (fPET) generated with the Atmosphere-Land Exchange Inverse (ALEXI) surface energy balance algorithm. The research team has demonstrated that diagnostic information about SM and evapotranspiration (ET) from MW and TIR remote sensing can significantly reduce SM drifts in LSMs such as Noah. The two different SM retrievals have been shown to be quite complementary: TIR provides relatively high spatial (down to 100 m) and low temporal resolution (due to cloud cover) retrievals over a wide range of GVF, while MW provides relatively low spatial (25 to 60 km) and high temporal resolution (can retrieve through cloud cover), but only over areas with low GVF. Furthermore, MW retrievals are sensitive to SM only in the first few centimeters of the soil profile, while TIR provides information about SM conditions integrated over the full root

Kalman filter data assimilation: Targeting observations and parameter estimation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bellsky, Thomas, E-mail: bellskyt@asu.edu; Kostelich, Eric J.; Mahalov, Alex

2014-06-15

This paper studies the effect of targeted observations on state and parameter estimates determined with Kalman filter data assimilation (DA) techniques. We first provide an analytical result demonstrating that targeting observations within the Kalman filter for a linear model can significantly reduce state estimation error as opposed to fixed or randomly located observations. We next conduct observing system simulation experiments for a chaotic model of meteorological interest, where we demonstrate that the local ensemble transform Kalman filter (LETKF) with targeted observations based on largest ensemble variance is skillful in providing more accurate state estimates than the LETKF with randomly locatedmore » observations. Additionally, we find that a hybrid ensemble Kalman filter parameter estimation method accurately updates model parameters within the targeted observation context to further improve state estimation.« less

The intelligence of observation: improving high school students' spatial ability by means of intervention unit

NASA Astrophysics Data System (ADS)

Patkin, Dorit; Dayan, Ester

2013-03-01

This case study of one class versus a control group focused on the impact of an intervention unit, which is not part of the regular curriculum, on the improvement of spatial ability of high school students (forty-six 12th-graders, aged 17-18, both boys and girls) in general as well as from a gender perspective. The study explored three sub-abilities: mental rotation (MR), spatial visualization (VS) and spatial orientation (SO). Findings indicated that the spatial orientation of the experimental group students had considerably improved. The findings also illustrated a significant gender-based advantage in favour of the boys in some of the spatial abilities even before the implementation of the intervention unit. The hypothesis relating to the reduction of the gender differences was not corroborated.

Fixed-dose combination of losartan and hydrochlorothiazide significantly improves endothelial function in uncontrolled hypertension by low-dose amlodipine: a randomized study.

PubMed

Takase, Bonpei; Nagata, Masayoshi

2014-12-01

Flow-mediated dilation (FMD) and nitroglycerin-mediated dilation (NMD) in the brachial artery are well-known indices for evaluating endothelial function (ECF). The blood pressure-lowering effects of the combination of losartan (ARB) and low-dose hydrochlorothiazide (H: ARB-H; ARB, 50 mg and H, 12.5 mg) are useful. The aim of the present study was to examine whether the combination of losartan and low-dose hydrochlorothiazide could improve ECF. To investigate the effect of ARB-H on ECF in patients with uncontrolled hypertension despite the use of amlodipine (2.5 mg daily), we performed a randomized controlled open-labeled study by using the envelope method and assigned 42 patients to either a control (CTRL) group or an ARB-H combination group, both of which received amlodipine 2.5 mg daily during the treatment period. In addition, both the CTRL (n=21, 69±7 years old) and ARB-H groups (n=21, 69±7 years old) received additional behavioral modification. Before and after 8 weeks of therapy, FMD and NMD were measured in both groups using novel FMD equipment (UNEXEF18G). Although baseline FMD was not different between the two groups, post-therapy FMD increased in the ARB-H group (2.97±1.56 to 3.95±1.86%, p<0.05) but did not change significantly in the CTRL group (2.95±1.43 to 3.11±1.27%, NS). No significant change was seen in NMD when comparing baseline and post-therapy values in either group. No treatment complications were observed. A fixed-dose combination of losartan and hydrochlorothiazide enhances ECF, suggesting that this combination might have both anti-hypertensive and anti-atherosclerotic effects in patients with hypertension.

Rescreening for abnormal vaginal flora in pregnancy and re-treating with clindamycin vaginal cream significantly increases cure and improvement rates.

PubMed

Lamont, R F; Taylor-Robinson, D; Bassett, P

2012-08-01

We investigated 199 pregnant women with bacterial vaginosis (BV) who received clindamycin vaginal cream (CVC) for three days and compared with 205 women treated with placebo. The vaginal flora was assessed at each visit. At the second visit, 71% in the CVC group were cured/improved, compared with 12% in the placebo group (P < 0.001). At visit 3 about 90% who responded to initial CVC treatment were still cured/improved. Of women who initially failed to respond to CVC and were given an additional seven-day course, 33% were cured/improved by the third visit, compared with 15% who failed to respond to placebo initially and were given a further seven-day course (P = 0.02). By visit 4, half the women in the CVC group who received additional treatment remained cured/improved, compared with 26% who had additional placebo (P = 0.004). In the CVC group, a change from abnormal to normal rose from 71% (visit 2) to 76% (visit 3) and 79% (visit 4). A similar trend was seen in women who received placebo but the proportions were significantly lower (12%, 24% and 33%, respectively). There is value in rescreening and re-treating women who remain BV-positive after initial clindamycin treatment.

Flavonol-rich dark cocoa significantly decreases plasma endothelin-1 and improves cognition in urban children.

PubMed

Calderón-Garcidueñas, Lilian; Mora-Tiscareño, Antonieta; Franco-Lira, Maricela; Cross, Janet V; Engle, Randall; Aragón-Flores, Mariana; Gómez-Garza, Gilberto; Jewells, Valerie; Medina-Cortina, Humberto; Solorio, Edelmira; Chao, Chih-Kai; Zhu, Hongtu; Mukherjee, Partha S; Ferreira-Azevedo, Lara; Torres-Jardón, Ricardo; D'Angiulli, Amedeo

2013-01-01

Air pollution exposures are linked to systemic inflammation, cardiovascular and respiratory morbidity and mortality, neuroinflammation and neuropathology in young urbanites. In particular, most Mexico City Metropolitan Area (MCMA) children exhibit subtle cognitive deficits, and neuropathology studies show 40% of them exhibiting frontal tau hyperphosphorylation and 51% amyloid-β diffuse plaques (compared to 0% in low pollution control children). We assessed whether a short cocoa intervention can be effective in decreasing plasma endothelin 1 (ET-1) and/or inflammatory mediators in MCMA children. Thirty gram of dark cocoa with 680 mg of total flavonols were given daily for 10.11 ± 3.4 days (range 9-24 days) to 18 children (10.55 years, SD = 1.45; 11F/7M). Key metabolite ratios in frontal white matter and in hippocampus pre and during cocoa intervention were quantified by magnetic resonance spectroscopy. ET-1 significantly decreased after cocoa treatment (p = 0.0002). Fifteen children (83%) showed a marginally significant individual improvement in one or both of the applied simple short memory tasks. Endothelial dysfunction is a key feature of exposure to particulate matter (PM) and decreased endothelin-1 bioavailability is likely useful for brain function in the context of air pollution. Our findings suggest that cocoa interventions may be critical for early implementation of neuroprotection of highly exposed urban children. Multi-domain nutraceutical interventions could limit the risk for endothelial dysfunction, cerebral hypoperfusion, neuroinflammation, cognitive deficits, structural volumetric detrimental brain effects, and the early development of the neuropathological hallmarks of Alzheimer's and Parkinson's diseases.

Flavonol-rich dark cocoa significantly decreases plasma endothelin-1 and improves cognition in urban children

PubMed Central

Calderón-Garcidueñas, Lilian; Mora-Tiscareño, Antonieta; Franco-Lira, Maricela; Cross, Janet V.; Engle, Randall; Aragón-Flores, Mariana; Gómez-Garza, Gilberto; Jewells, Valerie; Weili, Lin; Medina-Cortina, Humberto; Solorio, Edelmira; Chao, Chih-kai; Zhu, Hongtu; Mukherjee, Partha S.; Ferreira-Azevedo, Lara; Torres-Jardón, Ricardo; D'Angiulli, Amedeo

2013-01-01

Air pollution exposures are linked to systemic inflammation, cardiovascular and respiratory morbidity and mortality, neuroinflammation and neuropathology in young urbanites. In particular, most Mexico City Metropolitan Area (MCMA) children exhibit subtle cognitive deficits, and neuropathology studies show 40% of them exhibiting frontal tau hyperphosphorylation and 51% amyloid-β diffuse plaques (compared to 0% in low pollution control children). We assessed whether a short cocoa intervention can be effective in decreasing plasma endothelin 1 (ET-1) and/or inflammatory mediators in MCMA children. Thirty gram of dark cocoa with 680 mg of total flavonols were given daily for 10.11 ± 3.4 days (range 9–24 days) to 18 children (10.55 years, SD = 1.45; 11F/7M). Key metabolite ratios in frontal white matter and in hippocampus pre and during cocoa intervention were quantified by magnetic resonance spectroscopy. ET-1 significantly decreased after cocoa treatment (p = 0.0002). Fifteen children (83%) showed a marginally significant individual improvement in one or both of the applied simple short memory tasks. Endothelial dysfunction is a key feature of exposure to particulate matter (PM) and decreased endothelin-1 bioavailability is likely useful for brain function in the context of air pollution. Our findings suggest that cocoa interventions may be critical for early implementation of neuroprotection of highly exposed urban children. Multi-domain nutraceutical interventions could limit the risk for endothelial dysfunction, cerebral hypoperfusion, neuroinflammation, cognitive deficits, structural volumetric detrimental brain effects, and the early development of the neuropathological hallmarks of Alzheimer's and Parkinson's diseases. PMID:23986703

Combining Observations in the Reflective Solar and Thermal Domains for Improved Mapping of Carbon, Water and Energy FLuxes

NASA Technical Reports Server (NTRS)

Houborg, Rasmus; Anderson, Martha; Kustas, Bill; Rodell, Matthew

2011-01-01

This study investigates the utility of integrating remotely sensed estimates of leaf chlorophyll (C(sub ab)) into a thermal-based Two-Source Energy Balance (TSEB) model that estimates land-surface CO2 and energy fluxes using an analytical, light-use-efficiency (LUE) based model of canopy resistance. Day to day variations in nominal LUE (LUE(sub n)) were assessed for a corn crop field in Maryland U.S.A. through model calibration with CO2 flux tower observations. The optimized daily LUE(sub n) values were then compared to estimates of C(sub ab) integrated from gridded maps of chlorophyll content weighted over the tower flux source area. Changes in Cab exhibited a curvilinear relationship with corresponding changes in daily calibrated LUE(sub n) values derived from the tower flux data, and hourly water, energy and carbon flux estimation accuracies from TSEB were significantly improved when using C(sub ab) for delineating spatio-temporal variations in LUE(sub n). The results demonstrate the synergy between thermal infrared and shortwave reflective wavebands in producing valuable remote sensing data for monitoring of carbon and water fluxes.

Tunneled catheters with taurolidine-citrate-heparin lock solution significantly improve the inflammatory profile of hemodialysis patients.

PubMed

Fontseré, Néstor; Cardozo, Celia; Donate, Javier; Soriano, Alex; Muros, Mercedes; Pons, Mercedes; Mensa, Josep; Campistol, Josep M; Navarro-González, Juan F; Maduell, Francisco

2014-07-01

Mortality and morbidity are significantly higher among patients with dialysis catheters, which has been associated with chronic activation of the immune system. We hypothesized that bacteria colonizing the catheter lumen trigger an inflammatory response. We aimed to evaluate the inflammatory profile of hemodialysis patients before and after locking catheters with an antimicrobial lock solution. High-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), IL-10, and tumor necrosis factor alpha (TNF-α) were measured in serum, and levels of mRNA gene expression of IL-6, IL-10, and TNF-α were analyzed in peripheral blood mononuclear cells (PBMC). Samples were obtained at baseline and again after 3 months' use of taurolidine-citrate-heparin lock solution (TCHLS) in 31 hemodialysis patients. The rate of catheter-related bloodstream infections (CRBSI) was 1.08 per 1,000 catheter-days in the heparin period and 0.04 in the TCHLS period (P = 0.023). Compared with the baseline data, serum levels of hs-CRP and IL-6 showed median percent reductions of 18.1% and 25.2%, respectively (P < 0.01), without significant changes in TNF-α or IL-10 levels. Regarding cytokine gene expression in PBMC, the median mRNA expression levels of TNF-α and IL-6 decreased by 20% (P < 0.05) and 19.7% (P = 0.01), respectively, without changes in IL-10 expression levels. The use of TCHLS to maintain the catheter lumen sterility significantly reduces the incidence of CRBSI and improves the inflammatory profile in hemodialysis patients with tunneled catheters. Further studies are needed to evaluate the potential beneficial effects on clinical outcomes. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Tunneled Catheters with Taurolidine-Citrate-Heparin Lock Solution Significantly Improve the Inflammatory Profile of Hemodialysis Patients

PubMed Central

Cardozo, Celia; Donate, Javier; Soriano, Alex; Muros, Mercedes; Pons, Mercedes; Mensa, Josep; Campistol, Josep M.; Navarro-González, Juan F.; Maduell, Francisco

2014-01-01

Mortality and morbidity are significantly higher among patients with dialysis catheters, which has been associated with chronic activation of the immune system. We hypothesized that bacteria colonizing the catheter lumen trigger an inflammatory response. We aimed to evaluate the inflammatory profile of hemodialysis patients before and after locking catheters with an antimicrobial lock solution. High-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), IL-10, and tumor necrosis factor alpha (TNF-α) were measured in serum, and levels of mRNA gene expression of IL-6, IL-10, and TNF-α were analyzed in peripheral blood mononuclear cells (PBMC). Samples were obtained at baseline and again after 3 months' use of taurolidine-citrate-heparin lock solution (TCHLS) in 31 hemodialysis patients. The rate of catheter-related bloodstream infections (CRBSI) was 1.08 per 1,000 catheter-days in the heparin period and 0.04 in the TCHLS period (P = 0.023). Compared with the baseline data, serum levels of hs-CRP and IL-6 showed median percent reductions of 18.1% and 25.2%, respectively (P < 0.01), without significant changes in TNF-α or IL-10 levels. Regarding cytokine gene expression in PBMC, the median mRNA expression levels of TNF-α and IL-6 decreased by 20% (P < 0.05) and 19.7% (P = 0.01), respectively, without changes in IL-10 expression levels. The use of TCHLS to maintain the catheter lumen sterility significantly reduces the incidence of CRBSI and improves the inflammatory profile in hemodialysis patients with tunneled catheters. Further studies are needed to evaluate the potential beneficial effects on clinical outcomes. PMID:24820084

Co-overexpressing a Plasma Membrane and a Vacuolar Membrane Sodium/Proton Antiporter Significantly Improves Salt Tolerance in Transgenic Arabidopsis Plants.

PubMed

Pehlivan, Necla; Sun, Li; Jarrett, Philip; Yang, Xiaojie; Mishra, Neelam; Chen, Lin; Kadioglu, Asim; Shen, Guoxin; Zhang, Hong

2016-05-01

The Arabidopsis gene AtNHX1 encodes a vacuolar membrane-bound sodium/proton (Na(+)/H(+)) antiporter that transports Na(+) into the vacuole and exports H(+) into the cytoplasm. The Arabidopsis gene SOS1 encodes a plasma membrane-bound Na(+)/H(+) antiporter that exports Na(+) to the extracellular space and imports H(+) into the plant cell. Plants rely on these enzymes either to keep Na(+) out of the cell or to sequester Na(+) into vacuoles to avoid the toxic level of Na(+) in the cytoplasm. Overexpression of AtNHX1 or SOS1 could improve salt tolerance in transgenic plants, but the improved salt tolerance is limited. NaCl at concentration >200 mM would kill AtNHX1-overexpressing or SOS1-overexpressing plants. Here it is shown that co-overexpressing AtNHX1 and SOS1 could further improve salt tolerance in transgenic Arabidopsis plants, making transgenic Arabidopsis able to tolerate up to 250 mM NaCl treatment. Furthermore, co-overexpression of AtNHX1 and SOS1 could significantly reduce yield loss caused by the combined stresses of heat and salt, confirming the hypothesis that stacked overexpression of two genes could substantially improve tolerance against multiple stresses. This research serves as a proof of concept for improving salt tolerance in other plants including crops. © The Author 2016. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists.

Successful percutaneous coronary intervention significantly improves coronary sinus blood flow as assessed by transthoracic echocardiography.

PubMed

Lyubarova, Radmila; Boden, William E; Fein, Steven A; Schulman-Marcus, Joshua; Torosoff, Mikhail

2018-06-01

Transthoracic echocardiography (TTE) has been used to assess coronary sinus blood flow (CSBF), which reflects total coronary arterial blood flow. Successful angioplasty is expected to improve coronary arterial blood flow. Changes in CSBF after percutaneous coronary intervention (PCI), as assessed by TTE, have not been systematically evaluated. TTE can be utilized to reflect increased CSBF after a successful, clinically indicated PCI. The study cohort included 31 patients (18 females, 62 ± 11 years old) referred for diagnostic cardiac catheterization for suspected coronary artery disease and possible PCI, when clinically indicated. All performed PCIs were successful, with good angiographic outcome. CSBF per cardiac cycle (mL/beat) was measured using transthoracic two-dimensional and Doppler flow imaging as the product of coronary sinus (CS) area and CS flow time-velocity integral. CSBF per minute (mL/min) was calculated as the product of heart rate and CSBF per cardiac cycle. In each patient, CSBF was assessed prospectively, before and after cardiac catheterization with and without clinically indicated PCI. Within- and between-group differences in CSBF before and after PCI were assessed using repeated measures analysis of variance. Technically adequate CSBF measurements were obtained in 24 patients (77%). In patients who did not undergo PCI, there was no significant change in CSBF (278.1 ± 344.1 versus 342.7 ± 248.5, p = 0.36). By contrast, among patients who underwent PCI, CSBF increased significantly (254.3 ± 194.7 versus 618.3 ± 358.5 mL/min, p < 0.01, p-interaction = 0.03). Other hemodynamic and echocardiographic parameters did not change significantly before and after cardiac catheterization in either treatment group. Transthoracic echocardiographic assessment can be employed to document CSBF changes after angioplasty. Future studies are needed to explore the clinical utility of this noninvasive metric.

A cluster design controlled trial of arts-based observational skills training in primary care.

PubMed

Kirklin, Deborah; Duncan, Jane; McBride, Sandy; Hunt, Sam; Griffin, Mark

2007-04-01

To investigate whether the observational skills of doctors and nurses can be improved by arts-based observational skills training. We carried out a cluster design, controlled trial involving 42 general practitioners and 26 primary care nurses in 12 primary care practices in London. Six practices were allocated to the intervention arm and 6 to the control arm. The intervention group received 90 minutes of arts-based observational skills training. The control group received practical training in the management of psoriasis. Before and after this, control and intervention participants were asked to describe 3 dermatological photographs. Descriptions were scored blindly against a predetermined marking key. Participants completed a questionnaire about the intervention, and about their own confidence in diagnosing and referring suspicious pigmented skin lesions. Post-intervention scores were significantly higher in the intervention group compared with the control group (P < 0.001). The majority of participants judged the intervention relevant, enjoyable and valuable. A majority lacked confidence in their dermatological knowledge and skills. This study provides statistically significant evidence that arts-based observational skills training can improve the observational skills of doctors and nurses. It is important not to overstate the clinical significance of these findings, and to recognise that observational skills are just one of many complex and subtle factors affecting the quality of the clinical process. Further research is needed to assess the existence, nature and clinical significance of longer-term benefits, and to identify differences between professional groups.

Alosetron use in clinical practice: significant improvement in irritable bowel syndrome symptoms evaluated using the US Food and Drug Administration composite endpoint.

PubMed

Lacy, Brian E; Nicandro, Jean Paul; Chuang, Emil; Earnest, David L

2018-01-01

Alosetron is approved to treat women with severe IBS and diarrhea (IBS-D) who have failed standard therapy. In our study, we aimed to evaluate alosetron efficacy using new US Food and Drug Administration (FDA) endpoints and utilization in clinical practice. This prospective, open-label, multicenter, observational 12-week study evaluated women with severe IBS-D enrolled in the alosetron prescribing program. The coprimary FDA endpoints were changes from baseline in stool consistency and abdominal pain severity. Responders achieved a 30% decrease compared with baseline in weekly average of the worst abdominal pain in the past 24 h, and a 50% or greater reduction from baseline in the number of days/week with at least one stool of type 6 (mushy) or type 7 (watery) consistency. Secondary endpoints included changes from baseline in stool frequency, fecal urgency and fecal incontinence. Enrolled patients ( n = 192) were primarily White (90.6%), with a mean age of 44.5 years. Patient and physician rating of IBS severity was between moderate and severe (85.9% concordance, Spearman coefficient 0.429, p < 0.0001). Alosetron 0.5 mg twice daily (82.8%) was the most common dosing regimen. A total of 152 alosetron-treated patients completed the study. Of 105 fully evaluable patients, 45% met the FDA composite endpoint responder criteria for ⩾50% of the study period. Improvements in all individual symptoms were statistically significant compared with baseline. There were no serious adverse events, cases of colonic ischemia, or complications of constipation. In a clinical practice setting study, alosetron demonstrated treatment success using a rigorous FDA composite endpoint and also improved multiple other IBS symptoms, including fecal urgency and incontinence in women with severe IBS-D [ClinicalTrials.gov identifier: NCT01257477].

A Five-Stage Prediction-Observation-Explanation Inquiry-Based Learning Model to Improve Students' Learning Performance in Science Courses

ERIC Educational Resources Information Center

Hsiao, Hsien-Sheng; Chen, Jyun-Chen; Hong, Jon-Chao; Chen, Po-Hsi; Lu, Chow-Chin; Chen, Sherry Y.

2017-01-01

A five-stage prediction-observation-explanation inquiry-based learning (FPOEIL) model was developed to improve students' scientific learning performance. In order to intensify the science learning effect, the repertory grid technology-assisted learning (RGTL) approach and the collaborative learning (CL) approach were utilized. A quasi-experimental…

The significance of HIV 'blips' in resource-limited settings: is it the same? analysis of the treat Asia HIV Observational Database (TAHOD) and the Australian HIV Observational Database (AHOD).

PubMed

Kanapathipillai, Rupa; McManus, Hamish; Kamarulzaman, Adeeba; Lim, Poh Lian; Templeton, David J; Law, Matthew; Woolley, Ian

2014-01-01

Magnitude and frequency of HIV viral load blips in resource-limited settings, has not previously been assessed. This study was undertaken in a cohort from a high income country (Australia) known as AHOD (Australian HIV Observational Database) and another cohort from a mixture of Asian countries of varying national income per capita, TAHOD (TREAT Asia HIV Observational Database). Blips were defined as detectable VL (≥ 50 copies/mL) preceded and followed by undetectable VL (<50 copies/mL). Virological failure (VF) was defined as two consecutive VL ≥50 copies/ml. Cox proportional hazard models of time to first VF after entry, were developed. 5040 patients (AHOD n = 2597 and TAHOD n = 2521) were included; 910 (18%) of patients experienced blips. 744 (21%) and 166 (11%) of high- and middle/low-income participants, respectively, experienced blips ever. 711 (14%) experienced blips prior to virological failure. 559 (16%) and 152 (10%) of high- and middle/low-income participants, respectively, experienced blips prior to virological failure. VL testing occurred at a median frequency of 175 and 91 days in middle/low- and high-income sites, respectively. Longer time to VF occurred in middle/low income sites, compared with high-income sites (adjusted hazards ratio (AHR) 0.41; p<0.001), adjusted for year of first cART, Hepatitis C co-infection, cART regimen, and prior blips. Prior blips were not a significant predictor of VF in univariate analysis (AHR 0.97, p = 0.82). Differing magnitudes of blips were not significant in univariate analyses as predictors of virological failure (p = 0.360 for blip 50-≤1000, p = 0.309 for blip 50-≤400 and p = 0.300 for blip 50-≤200). 209 of 866 (24%) patients were switched to an alternate regimen in the setting of a blip. Despite a lower proportion of blips occurring in low/middle-income settings, no significant difference was found between settings. Nonetheless, a substantial number of participants were switched

Significant and continuous improvement in bone mineral density among type 1 Gaucher disease patients treated with velaglucerase alfa: 69-month experience, including dose reduction.

PubMed

Elstein, Deborah; Foldes, A Joseph; Zahrieh, David; Cohn, Gabriel M; Djordjevic, Maja; Brutaru, Costin; Zimran, Ari

2011-06-15

Since bone pathology is a major concern in type 1 Gaucher disease (GD1), we evaluated bone mineral density (BMD) in adults receiving velaglucerase alfa in the seminal Phase I/II and extension trial. Ten treatment-naïve symptomatic patients with GD1 (four men, six women; median age 35years, range 18-62years) were included; of these, four patients were receiving bisphosphonates at enrollment. Using WHO criteria to classify the lumbar spine (LS) and femoral neck (FN) BMD T-scores, respectively, one (10%) and four (40%) patients had osteoporosis; eight (80%) and five (50%) had osteopenia; and one each (10%) was in the normal range, at baseline. By Month 69, two LS and one FN osteopenic patients normalized and one FN osteoporotic patient became osteopenic; change was seen only in patients not receiving bisphosphonates. Significant improvements in BMD Z-scores were seen at the LS by Month 24 and at the FN by Month 33 and were continuous thereafter. In linear mixed models, Z-scores were significantly lower than the reference population at baseline and improved significantly with treatment (LS and FN both P<0.01); analysis of the subgroup of patients not receiving bisphosphonates showed similar results. In conclusion, in this small cohort, velaglucerase alfa was associated with clinically meaningful and statistically significant LS and FN BMD improvements as early as Month 24 (LS) and 33 (FN), despite dose reduction and significant baseline skeletal pathology. These results suggest that velaglucerase alfa may hold promise in the management of skeletal pathology associated with GD1. Copyright © 2011 Elsevier Inc. All rights reserved.

Significantly enhanced thermal conductivity of indium arsenide nanowires via sulfur passivation.

PubMed

Xiong, Yucheng; Tang, Hao; Wang, Xiaomeng; Zhao, Yang; Fu, Qiang; Yang, Juekuan; Xu, Dongyan

2017-10-16

In this work, we experimentally investigated the effect of sulfur passivation on thermal transport in indium arsenide (InAs) nanowires. Our measurement results show that thermal conductivity can be enhanced by a ratio up to 159% by sulfur passivation. Current-voltage (I-V) measurements were performed on both unpassivated and S-passivated InAs nanowires to understand the mechanism of thermal conductivity enhancement. We observed a remarkable improvement in electrical conductivity upon sulfur passivation and a significant contribution of electrons to thermal conductivity, which account for the enhanced thermal conductivity of the S-passivated InAs nanowires.

Improving coordination and integration of observations of Arctic change

NASA Astrophysics Data System (ADS)

Perovich, Donald; Payne, John; Eicken, Hajo

2012-10-01

U.S. Arctic Observing Coordination Workshop;Anchorage, Alaska, 20-22 March 2012 The Arctic is undergoing tremendous changes. Permafrost is thawing, ice sheets are melting, and sea ice is thinning and retreating. These changes are impacting ecosystems and human activities. Observing, understanding, and responding to these changes are the central themes of the U.S. Interagency Study of Environmental Arctic Change (SEARCH, http://www.arcus.org/search/index.php). SEARCH brings together academic and government agency scientists and stakeholders to prioritize, plan, conduct, and synthesize research focused on Arctic environmental change. The U.S. Arctic Observing Coordination Workshop (http://www.arcus.org/search/meetings/2012/coordination-workshop/) focused on two key themes for cross-disciplinary and cross-agency collaboration: (1) understanding and predicting sea ice changes and their consequences for ecosystems, human activities, and climate and (2) determining consequences of loss and warming of shallow permafrost on Arctic and global systems.

Development of the Huddle Observation Tool for structured case management discussions to improve situation awareness on inpatient clinical wards.

PubMed

Edbrooke-Childs, Julian; Hayes, Jacqueline; Sharples, Evelyn; Gondek, Dawid; Stapley, Emily; Sevdalis, Nick; Lachman, Peter; Deighton, Jessica

2018-05-01

'Situation Awareness For Everyone' (SAFE) was a 3-year project which aimed to improve situation awareness in clinical teams in order to detect potential deterioration and other potential risks to children on hospital wards. The key intervention was the 'huddle', a structured case management discussion which is central to facilitating situation awareness. This study aimed to develop an observational assessment tool to assess the team processes occurring during huddles, including the effectiveness of the huddle. A cross-sectional observational design was used to psychometrically develop the 'Huddle Observation Tool' (HOT) over three phases using standardised psychometric methodology. Huddles were observed across four NHS paediatric wards participating in SAFE by five researchers; two wards within specialist children hospitals and two within district general hospitals, with location, number of beds and length of stay considered to make the sample as heterogeneous as possible. Inter-rater reliability was calculated using the weighted kappa and intraclass correlation coefficient. Inter - rater reliability was acceptable for the collaborative culture (weighted kappa=0.32, 95% CI 0.17 to 0.42), environment items (weighted kappa=0.78, 95% CI 0.52 to 1) and total score (intraclass correlation coefficient=0.87, 95% CI 0.68 to 0.95). It was lower for the structure and risk management items, suggesting that these were more variable in how observers rated them. However, agreement on the global score for huddles was acceptable. We developed an observational assessment tool to assess the team processes occurring during huddles, including the effectiveness of the huddle. Future research should examine whether observational evaluations of huddles are associated with other indicators of safety on clinical wards (eg, safety climate and incidents of patient harm), and whether scores on the HOT are associated with improved situation awareness and reductions in deterioration and adverse

Development of the Huddle Observation Tool for structured case management discussions to improve situation awareness on inpatient clinical wards

PubMed Central

Edbrooke-Childs, Julian; Hayes, Jacqueline; Sharples, Evelyn; Gondek, Dawid; Stapley, Emily; Lachman, Peter; Deighton, Jessica

2018-01-01

Background ‘Situation Awareness For Everyone’ (SAFE) was a 3-year project which aimed to improve situation awareness in clinical teams in order to detect potential deterioration and other potential risks to children on hospital wards. The key intervention was the ‘huddle’, a structured case management discussion which is central to facilitating situation awareness. This study aimed to develop an observational assessment tool to assess the team processes occurring during huddles, including the effectiveness of the huddle. Methods A cross-sectional observational design was used to psychometrically develop the ‘Huddle Observation Tool’ (HOT) over three phases using standardised psychometric methodology. Huddles were observed across four NHS paediatric wards participating in SAFE by five researchers; two wards within specialist children hospitals and two within district general hospitals, with location, number of beds and length of stay considered to make the sample as heterogeneous as possible. Inter-rater reliability was calculated using the weighted kappa and intraclass correlation coefficient. Results Inter-rater reliability was acceptable for the collaborative culture (weighted kappa=0.32, 95% CI 0.17 to 0.42), environment items (weighted kappa=0.78, 95% CI 0.52 to 1) and total score (intraclass correlation coefficient=0.87, 95% CI 0.68 to 0.95). It was lower for the structure and risk management items, suggesting that these were more variable in how observers rated them. However, agreement on the global score for huddles was acceptable. Conclusion We developed an observational assessment tool to assess the team processes occurring during huddles, including the effectiveness of the huddle. Future research should examine whether observational evaluations of huddles are associated with other indicators of safety on clinical wards (eg, safety climate and incidents of patient harm), and whether scores on the HOT are associated with improved situation

Improvement of the Management of Infants, Children and Adults with a Molecular Diagnosis of Enterovirus Meningitis during Two Observational Study Periods

PubMed Central

Archimbaud, Christine; Ouchchane, Lemlih; Mirand, Audrey; Chambon, Martine; Demeocq, François; Labbé, André; Laurichesse, Henri; Schmidt, Jeannot; Clavelou, Pierre; Aumaître, Olivier; Regagnon, Christel; Bailly, Jean-Luc; Henquell, Cécile; Peigue-Lafeuille, Hélène

2013-01-01

Enteroviruses (EVs) are a major cause of aseptic meningitis, and RNA detection using molecular assay is the gold standard diagnostic test. The aim of this study was to assess the impact of an EV positive diagnosis on the clinical management of patients admitted for meningitis over the course of two observational study periods (2005 and 2008–09) in the same clinical departments. We further investigated in multivariate analysis various factors possibly associated with hospital length of stay (LOS) in all age groups (infants, children, and adults). The results showed an overall improvement in the management of patients (n = 142) between the study periods, resulting in a significantly shorter hospital LOS for adults and children, and a shorter duration of antibiotic use for adults and infants. In multivariate analysis, we observed that the time from molecular test results to discharge of patients and the median duration of antibiotic treatment were associated with an increase in LOS in all age groups. In addition, among adults, the turnaround time of the molecular assay was significantly correlated with LOS. The use of CT scan in children and hospital admission outside the peak of EV prevalence in infants tended to increase LOS. In conclusion, the shorter length of stay of patients with meningitis in this study was due to various factors including the rapidity of the EV molecular test (particularly in adults), greater physician responsiveness after a positive result (in adults and children), and greater experience on the part of physicians in handling EV meningitis, as evidenced by the shorter duration of antibiotic use in adults and infants. PMID:23874676

Using the Fire Weather Index (FWI) to improve the estimation of fire emissions from fire radiative power (FRP) observations

NASA Astrophysics Data System (ADS)

Di Giuseppe, Francesca; Rémy, Samuel; Pappenberger, Florian; Wetterhall, Fredrik

2018-04-01

The atmospheric composition analysis and forecast for the European Copernicus Atmosphere Monitoring Services (CAMS) relies on biomass-burning fire emission estimates from the Global Fire Assimilation System (GFAS). The GFAS is a global system and converts fire radiative power (FRP) observations from MODIS satellites into smoke constituents. Missing observations are filled in using persistence, whereby observed FRP values from the previous day are progressed in time until a new observation is recorded. One of the consequences of this assumption is an increase of fire duration, which in turn translates into an increase of emissions estimated from fires compared to what is available from observations. In this study persistence is replaced by modelled predictions using the Canadian Fire Weather Index (FWI), which describes how atmospheric conditions affect the vegetation moisture content and ultimately fire duration. The skill in predicting emissions from biomass burning is improved with the new technique, which indicates that using an FWI-based model to infer emissions from FRP is better than persistence when observations are not available.

Carbon Observations from Geostationary Earth Orbit as Part of an Integrated Observing System for Atmospheric Composition

NASA Astrophysics Data System (ADS)

Edwards, D. P.

2015-12-01

This presentation describes proposed satellite carbon measurements from the CHRONOS mission. The primary goal of this experiment is to measure the atmospheric pollutants carbon monoxide (CO) and methane (CH4) from geostationary orbit, with hourly observations of North America at high spatial resolution. CHRONOS observations would provide measurements not currently available or planned as part of a surface, suborbital and satellite integrated observing system for atmospheric composition over North America. Carbon monoxide is produced by combustion processes such as urban activity and wildfires, and serves as a proxy for other combustion pollutants that are not easily measured. Methane has diverse anthropogenic sources ranging from fossil fuel production, animal husbandry, agriculture and waste management. The impact of gas exploration in the Western States of the USA and oil extraction from the Canadian tar sands will be particular foci of the mission, as will the poorly-quantified natural CH4 emissions from wetlands and thawing permafrost. In addition to characterizing pollutant sources, improved understanding of the domestic CH4 budget is a priority for policy decisions related to short-lived climate forcers. A primary motivation for targeting CO is its value as a tracer of atmospheric pollution, and CHRONOS measurements will provide insight into local and long-range transport across the North American continent, as well as the processes governing the entrainment and venting of pollution in and out of the planetary boundary layer. As a result of significantly improved characterization of diurnal changes in atmospheric composition, CHRONOS observations will find direct societal applications for air quality regulation and forecasting. We present a quantification of this expected improvement in the prediction of near-surface concentrations when CHRONOS measurements are used in Observation System Simulation Experiments (OSSEs). If CHRONOS and the planned NASA Earth

The National Emissions Inventory Significantly Overestimates NOx Emissions: Analysis of CMAQ and in situ observations from DISCOVER-AQ

NASA Astrophysics Data System (ADS)

Anderson, D. C.; Dickerson, R. R.; Loughner, C.

2013-12-01

NOx and CO not only adversely impact human health, but they, along with associated VOCs, are also important precursors for O3 formation. While ambient NOx and CO concentrations have decreased dramatically over the past 10-20 years, O3 has remained a more recalcitrant problem, particularly in the Baltimore/Washington region. Reduction of O3 production requires that emissions inventories, such as the National Emissions Inventory (NEI), accurately capture total emissions of CO and NOx while also correctly apportioning them among different sectors. Previous evaluations of the NEI paint different pictures of its accuracy, with assertions that it overestimates either one or both of CO and NOx from anywhere between 25 percent to a factor of 2. These conflicting claims warrant further investigation. In this study, measurements of NOx and CO taken aboard the NOAA P3B airplane during the 2011 DISCOVER-AQ field campaign were used to determine the NOx/CO emissions ratio at 6 locations in the Washington/Baltimore region. An average molar emissions ratio of 12.8 × 1.2 CO/NOx was found by calculating the change in CO over the change in NOx from vertical concentration profiles in the planetary boundary layer. Ratios showed little variation with location. Observed values were approximately a factor of 1.35 - 1.75 times greater than that predicted by the annual, countywide emissions ratio from the 2008 NEI. When compared to a temporalized, gridded version of the inventory processed by SMOKE, ratio observations were greater than that predicted by inventories by up to a factor of 2. Comparison of the in situ measurements and remotely sensed observations from MOPITT of CO to the Community Multiscale Air Quality (CMAQ) model agree within 10-35 percent, with the model higher on average. Measurements of NOy by two separate analytical techniques, on the other hand, show that CMAQ consistently and significantly overestimates NOy concentrations. Combined with the CO observations, this

High energy electrons beyond 100 GEV observed by emulsion chamber

NASA Technical Reports Server (NTRS)

Nishimura, J.; Fujii, M.; Yoshida, A.; Taira, T.; Aizu, H.; Nomura, Y.; Kobayashi, T.; Kazuno, M.; Nishio, A.; Golden, R. L.

1986-01-01

Much efforts have been expended to observe the spectrum of electrons in the high energy region with large area emulsion chambers exposed at balloon altitudes, and now 15 electrons beyond 1 TeV have been observed. The observed integral flux at 1 TeV is (3.24 + or - 0.87)x10(-5)/sq m sec sr. The statistics of the data around a few hundred GeV are also improving by using new shower detecting films of high sensitivity. The astrophysical significance of the observed spectrum are discussed for the propagation of electrons based on the leaky box and the nested leaky box model.

Electron Emission Observations from As-Grown and Vacuum-Coated Chemical Vapor Deposited Diamond

NASA Technical Reports Server (NTRS)

Lamouri, A.; Wang, Yaxin; Mearini, G. T.; Krainsky, I. L.; Dayton, J. A., Jr.; Mueller,W.

1996-01-01

Field emission has been observed from chemical vapor deposited diamond grown on Mo and Si substrates. Emission was observed at fields as low as 20 kV/cm. The samples were tested in the as-grown form, and after coating with thin films of Au, CsI, and Ni. The emission current was typically maximum at the onset of the applied field, but was unstable, and decreased rapidly with time from the as-grown films. Thin Au layers, approximately 15 nm thick, vacuum deposited onto the diamond samples significantly improved the stability of the emission current at values approximately equal to those from uncoated samples at the onset of the applied field. Thin layers of CsI, approximately 5 nm thick, were also observed to improve the stability of the emission current but at values less than those from the uncoated samples at the onset of the applied field. While Au and CsI improved the stability of the emission, Ni was observed to have no effect.

The Potential Role of Grid-Like Software in Bedside Chest Radiography in Improving Image Quality and Dose Reduction: An Observer Preference Study.

PubMed

Ahn, Su Yeon; Chae, Kum Ju; Goo, Jin Mo

2018-01-01

To compare the observer preference of image quality and radiation dose between non-grid, grid-like, and grid images. Each of the 38 patients underwent bedside chest radiography with and without a grid. A grid-like image was generated from a non-grid image using SimGrid software (Samsung Electronics Co. Ltd.) employing deep-learning-based scatter correction technology. Two readers recorded the preference for 10 anatomic landmarks and the overall appearance on a five-point scale for a pair of non-grid and grid-like images, and a pair of grid-like and grid images, respectively, which were randomly presented. The dose area product (DAP) was also recorded. Wilcoxon's rank sum test was used to assess the significance of preference. Both readers preferred grid-like images to non-grid images significantly ( p < 0.001); with a significant difference in terms of the preference for grid images to grid-like images ( p = 0.317, 0.034, respectively). In terms of anatomic landmarks, both readers preferred grid-like images to non-grid images ( p < 0.05). No significant differences existed between grid-like and grid images except for the preference for grid images in proximal airways by two readers, and in retrocardiac lung and thoracic spine by one reader. The median DAP were 1.48 (range, 1.37-2.17) dGy * cm 2 in grid images and 1.22 (range, 1.11-1.78) dGy * cm 2 in grid-like images with a significant difference ( p < 0.001). The SimGrid software significantly improved the image quality of non-grid images to a level comparable to that of grid images with a relatively lower level of radiation exposure.

Using in-situ observations of atmospheric water vapor isotopes to benchmark and isotope-enabled General Circulation Models and improve ice core paleo-climate reconstruction

NASA Astrophysics Data System (ADS)

Steen-Larsen, Hans Christian; Sveinbjörnsdottir, Arny; Masson-Delmotte, Valerie; Werner, Martin; Risi, Camille; Yoshimura, Kei

2016-04-01

We have since 2010 carried out in-situ continuous water vapor isotope observations on top of the Greenland Ice Sheet (3 seasons at NEEM), in Svalbard (1 year), in Iceland (4 years), in Bermuda (4 years). The expansive dataset containing high accuracy and precision measurements of δ18O, δD, and the d-excess allow us to validate and benchmark the treatment of the atmospheric hydrological cycle's processes in General Circulation Models using simulations nudged to reanalysis products. Recent findings from both Antarctica and Greenland have documented strong interaction between the snow surface isotopes and the near surface atmospheric water vapor isotopes on diurnal to synoptic time scales. In fact, it has been shown that the snow surface isotopes take up the synoptic driven atmospheric water vapor isotopic signal in-between precipitation events, erasing the precipitation isotope signal in the surface snow. This highlights the importance of using General or Regional Climate Models, which accurately are able to simulate the atmospheric water vapor isotopic composition, to understand and interpret the ice core isotope signal. With this in mind we have used three isotope-enabled General Circulation Models (isoGSM, ECHAM5-wiso, and LMDZiso) nudged to reanalysis products. We have compared the simulations of daily mean isotope values directly with our in-situ observations. This has allowed us to characterize the variability of the isotopic composition in the models and compared it to our observations. We have specifically focused on the d-excess in order to characterize why both the mean and the variability is significantly lower than our observations. We argue that using water vapor isotopes to benchmark General Circulation Models offers an excellent tool for improving the treatment and parameterization of the atmospheric hydrological cycle. Recent studies have documented a very large inter-model dispersion in the treatment of the Arctic water cycle under a future global

Cinacalcet may improve oxidative DNA damage in maintenance hemodialysis patients: an observational study.

PubMed

Ari, Elif; Kaya, Yuksel; Demir, Halit; Asicioglu, Ebru; Eren, Zehra; Celik, Eray; Arikan, Hakki

2014-09-01

Oxidative stress is accepted as a non-classical cardiovascular risk factor in patients on maintenance hemodialysis (HD). The aim of this study was to evaluate the impact of cinacalcet on oxidative stress biomarkers, oxidative DNA damage (8-hydroxy-2'-deoxyguanosine/deoxyguanosine), endothelial function (FMD %) and carotid artery intima-media thickness (CIMT) in HD patients. Forty-two chronic HD patients with secondary hyperparathyroidism undergoing 60 mg/day cinacalcet treatment with a follow-up of 6 months and 38 age- and sex-matched healthy individuals were included in this prospective study. Plasma malondialdehyde (MDA) levels and 8-hydroxy-2'-deoxyguanosine/deoxyguanosine ratio (8-OHdG/dG) were determined as oxidative stress markers. Superoxide dismutase (SOD), paraoxonase (PON), catalase (CAT), carbonic anhydrase (CAN) and glutathione peroxidase (GPx) activities were measured as antioxidants. FMD % and CIMT were assessed by ultrasonography. MDA levels were decreased; SOD, PON, CAT, CAN and GPx activities were increased after 6 months of cinacalcet treatment in HD patients. Although CIMT remained stabile, there was a significant improvement in FMD % as well as a notable reduction trend in 8-OHdG/dG ratio after 6 months of treatment. Our data have demonstrated that cinacalcet improves oxidative stress, genomic damage, endothelial function and increases antioxidant protection in HD patients after 6 months of treatment.

Detection of significant variation in acoustic output of an electromagnetic lithotriptor.

PubMed

Pishchalnikov, Yuri A; McAteer, James A; Vonderhaar, R Jason; Pishchalnikova, Irina V; Williams, James C; Evan, Andrew P

2006-11-01

We describe the observation of significant instability in the output of an electromagnetic lithotriptor. This instability had a form that was not detected by routine assessment, but rather was observed only by collecting many consecutive shock waves in nonstop regimen. A Dornier DoLi-50 lithotriptor used exclusively for basic research was tested and approved by the regional technician. This assessment included hydrophone measures at select power levels with the collection of about 25 shock waves per setting. Subsequent laboratory characterization used a fiberoptic hydrophone and storage oscilloscope for data acquisition. Waveforms were collected nonstop for hundreds of pulses. Output was typically stable for greater than 1,000 shock waves but substantial fluctuations in acoustic pressures were also observed. For example, output at power level 3 (mean peak positive acoustic pressure +/- SD normally 44 +/- 2 MPa) increased dramatically to greater than 50 MPa or decreased significantly to approximately 30 MPa for hundreds of shock waves. The cause of instability was eventually traced to a faulty lithotriptor power supply. Instability in lithotriptor acoustic output can occur and it may not be detected by routine assessment. Collecting waveforms in a nonstop regimen dramatically increases sampling size, improving the detection of instability. Had the instability that we observed occurred during patient treatment, the energy delivered may well have exceeded the planned dose. Since the potential for adverse effects in lithotripsy increases as the dose is increased, it would be valuable to develop ways to better monitor the acoustic output of lithotriptors.

Improvement of the clinical outcome in Ankylosing spondylitis by balneotherapy.

PubMed

Yurtkuran, Merih; Ay, Alev; Karakoç, Yüksel

2005-07-01

This study is designed to show the efficacy of balneotherapy and balneotherapy (BT) + nonsteroid antiinflammatory drug (NSAID) use in Ankylosing spondylitis (AS) patients. In this prospective study, BT, BT+ NSAID and NSAID therapy in 61 patients with AS were evaluated by ASAS core set. BT group (21 patients) was treated only with BT for 20 min, once a day, 5 days a week, over a period of 3 weeks. BT+NSAID group (20 patients) was treated with 1000 mg naproxen as well as BT. NSAID group (20 patients) was treated with 1000 mg naproxen. All of the participants did respiratory and postural exercises for 20 min a day and for the whole study period. Each patient was evaluated on admission (before treatment), at the end of the therapy and 6 months after the treatment. At the end of the study, statistically significant improvement was observed in all the clinical parameters of the patients in BT (G1), BT+NSAID (G2) and NSAID (G3) groups. This significant symptomatic and clinical improvement was maintained even 6 months after the treatment. The changes from baseline to follow up were similar in G1 and G2 except duration of morning stiffness (DMS) and chest expansion (CE). Improvements in CE and DMS were better in G1 and G2, respectively. Improvements observed in G1 and G2 were superior to the improvements observed in G3 for the variables of morning pain, nocturnal pain, DMS, global well being of the patient, occiput-wall distance, CE, finger to floor distance and functional index. In Schober test, improvement observed in G1 was statistically superior to G3. We concluded that BT can be suggested as an effective symptomatic treatment modality in patients with AS. Furthermore, sufficient improvement in clinical parameters can be obtained by BT alone.

Does ownership of improved dairy cow breeds improve child nutrition? A pathway analysis for Uganda.

PubMed

Kabunga, Nassul S; Ghosh, Shibani; Webb, Patrick

2017-01-01

The promotion of livestock production is widely believed to support enhanced diet quality and child nutrition, but the empirical evidence for this causal linkage remains narrow and ambiguous. This study examines whether adoption of improved dairy cow breeds is linked to farm-level outcomes that translate into household-level benefits including improved child nutrition outcomes in Uganda. Using nationwide data from Uganda's National Panel Survey, propensity score matching is used to create an unbiased counterfactual, based on observed characteristics, to assess the net impacts of improved dairy cow adoption. All estimates were tested for robustness and sensitivity to variations in observable and unobservable confounders. Results based on the matched samples showed that households adopting improved dairy cows significantly increased milk yield-by over 200% on average. This resulted in higher milk sales and milk intakes, demonstrating the potential of this agricultural technology to both integrate households into modern value chains and increase households' access to animal source foods. Use of improved dairy cows increased household food expenditures by about 16%. Although undernutrition was widely prevalent in the study sample and in matched households, the adoption of improved dairy cows was associated with lower child stunting in adopter household. In scale terms, results also showed that holding larger farms tends to support adoption, but that this also stimulates the household's ability to achieve gains from adoption, which can translate into enhanced nutrition.

Significant improvement of intestinal microbiota of gibel carp (Carassius auratus gibelio) after traditional Chinese medicine feeding.

PubMed

Wu, Z B; Gatesoupe, F-J; Li, T T; Wang, X H; Zhang, Q Q; Feng, D Y; Feng, Y Q; Chen, H; Li, A H

2018-03-01

Increasing attention has been attracted to intestinal microbiota, due to interactions with nutrition, metabolism and immune defence of the host. Traditional Chinese medicine (TCM) feed additives have been applied in aquaculture to improve fish health, but the interaction with fish gut microbiota is still poorly understood. This study aimed to explore the effect of adding TCM in feed on the intestinal microbiota of gibel carp (Carassius auratus gibelio). Bacterial communities of 16 fish intestinal contents and one water sample were characterized by high-throughput sequencing and analysis of the V4-V5 region of the 16S rRNA gene. The results showed that the composition and structure of the bacterial community were significantly altered by the TCM feeding. Some phyla increased markedly (Proteobacteria, Actinobacteria, Acidobacteria, etc.), while Fusobacteria were significantly reduced. Concurrently, the richness and diversity of the taxonomic units increased, and the microbiota composition of TCM-treated fish was more homogeneous among individuals. At the genus level, the addition of TCM tended to reduce the incidence of potential pathogens (Aeromonas, Acinetobacter and Shewanella), while stimulating the emergence of some potential probiotics (Lactobacillus, Lactococcus, Bacillus and Pseudomonas). These data suggested that the feed additive could regulate the fish intestinal microbiota by reinforcing the microbial balance. This study may provide useful information for further application of TCM for diseases prevention and stress management in aquaculture. © 2017 The Society for Applied Microbiology.

Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses

PubMed Central

Liu, Ruijie; Holik, Aliaksei Z.; Su, Shian; Jansz, Natasha; Chen, Kelan; Leong, Huei San; Blewitt, Marnie E.; Asselin-Labat, Marie-Liesse; Smyth, Gordon K.; Ritchie, Matthew E.

2015-01-01

Variations in sample quality are frequently encountered in small RNA-sequencing experiments, and pose a major challenge in a differential expression analysis. Removal of high variation samples reduces noise, but at a cost of reducing power, thus limiting our ability to detect biologically meaningful changes. Similarly, retaining these samples in the analysis may not reveal any statistically significant changes due to the higher noise level. A compromise is to use all available data, but to down-weight the observations from more variable samples. We describe a statistical approach that facilitates this by modelling heterogeneity at both the sample and observational levels as part of the differential expression analysis. At the sample level this is achieved by fitting a log-linear variance model that includes common sample-specific or group-specific parameters that are shared between genes. The estimated sample variance factors are then converted to weights and combined with observational level weights obtained from the mean–variance relationship of the log-counts-per-million using ‘voom’. A comprehensive analysis involving both simulations and experimental RNA-sequencing data demonstrates that this strategy leads to a universally more powerful analysis and fewer false discoveries when compared to conventional approaches. This methodology has wide application and is implemented in the open-source ‘limma’ package. PMID:25925576

Improving Hydrological Simulations by Incorporating GRACE Data for Parameter Calibration

NASA Astrophysics Data System (ADS)

Bai, P.

2017-12-01

Hydrological model parameters are commonly calibrated by observed streamflow data. This calibration strategy is questioned when the modeled hydrological variables of interest are not limited to streamflow. Well-performed streamflow simulations do not guarantee the reliable reproduction of other hydrological variables. One of the reasons is that hydrological model parameters are not reasonably identified. The Gravity Recovery and Climate Experiment (GRACE) satellite-derived total water storage change (TWSC) data provide an opportunity to constrain hydrological model parameterizations in combination with streamflow observations. We constructed a multi-objective calibration scheme based on GRACE-derived TWSC and streamflow observations, with the aim of improving the parameterizations of hydrological models. The multi-objective calibration scheme was compared with the traditional single-objective calibration scheme, which is based only on streamflow observations. Two monthly hydrological models were employed on 22 Chinese catchments with different hydroclimatic conditions. The model evaluation was performed using observed streamflows, GRACE-derived TWSC, and evapotranspiraiton (ET) estimates from flux towers and from the water balance approach. Results showed that the multi-objective calibration provided more reliable TWSC and ET simulations without significant deterioration in the accuracy of streamflow simulations than the single-objective calibration. In addition, the improvements of TWSC and ET simulations were more significant in relatively dry catchments than in relatively wet catchments. This study highlights the importance of including additional constraints besides streamflow observations in the parameter estimation to improve the performances of hydrological models.

Biomarkers from distinct biological pathways improve early risk stratification in medical emergency patients: the multinational, prospective, observational TRIAGE study.

PubMed

Schuetz, Philipp; Hausfater, Pierre; Amin, Devendra; Amin, Adina; Haubitz, Sebastian; Faessler, Lukas; Kutz, Alexander; Conca, Antoinette; Reutlinger, Barbara; Canavaggio, Pauline; Sauvin, Gabrielle; Bernard, Maguy; Huber, Andreas; Mueller, Beat

2015-10-29

Early risk stratification in the emergency department (ED) is vital to reduce time to effective treatment in high-risk patients and to improve patient flow. Yet, there is a lack of investigations evaluating the incremental usefulness of multiple biomarkers measured upon admission from distinct biological pathways for predicting fatal outcome and high initial treatment urgency in unselected ED patients in a multicenter and multinational setting. We included consecutive, adult, medical patients seeking ED care into this observational, cohort study in Switzerland, France and the USA. We recorded initial clinical parameters and batch-measured prognostic biomarkers of inflammation (pro-adrenomedullin [ProADM]), stress (copeptin) and infection (procalcitonin). During a 30-day follow-up, 331 of 7132 (4.6 %) participants reached the primary endpoint of death within 30 days. In logistic regression models adjusted for conventional risk factors available at ED admission, all three biomarkers strongly predicted the risk of death (AUC 0.83, 0.78 and 0.75), ICU admission (AUC 0.67, 0.69 and 0.62) and high initial triage priority (0.67, 0.66 and 0.58). For the prediction of death, ProADM significantly improved regression models including (a) clinical information available at ED admission (AUC increase from 0.79 to 0.84), (b) full clinical information at ED discharge (AUC increase from 0.85 to 0.88), and (c) triage information (AUC increase from 0.67 to 0.83) (p <0.01 for each comparison). Similarly, ProADM also improved clinical models for prediction of ICU admission and high initial treatment urgency. Results were robust in regard to predefined patient subgroups by center, main diagnosis, presenting symptoms, age and gender. Combination of clinical information with results of blood biomarkers measured upon ED admission allows early and more adequate risk stratification in individual unselected medical ED patients. A randomized trial is needed to answer the question whether

Improving the Operations of the Earth Observing One Mission via Automated Mission Planning

NASA Technical Reports Server (NTRS)

Chien, Steve A.; Tran, Daniel; Rabideau, Gregg; Schaffer, Steve; Mandl, Daniel; Frye, Stuart

2010-01-01

We describe the modeling and reasoning about operations constraints in an automated mission planning system for an earth observing satellite - EO-1. We first discuss the large number of elements that can be naturally represented in an expressive planning and scheduling framework. We then describe a number of constraints that challenge the current state of the art in automated planning systems and discuss how we modeled these constraints as well as discuss tradeoffs in representation versus efficiency. Finally we describe the challenges in efficiently generating operations plans for this mission. These discussions involve lessons learned from an operations model that has been in use since Fall 2004 (called R4) as well as a newer more accurate operations model operational since June 2009 (called R5). We present analysis of the R5 software documenting a significant (greater than 50%) increase in the number of weekly observations scheduled by the EO-1 mission. We also show that the R5 mission planning system produces schedules within 15% of an upper bound on optimal schedules. This operational enhancement has created value of millions of dollars US over the projected remaining lifetime of the EO-1 mission.

Improved quantification of mountain snowpack properties using observations from Unmanned Air Vehicles (UAVs)

NASA Astrophysics Data System (ADS)

Shea, J. M.; Harder, P.; Pomeroy, J. W.; Kraaijenbrink, P. D. A.

2017-12-01

Mountain snowpacks represent a critical seasonal reservoir of water for downstream needs, and snowmelt is a significant component of mountain hydrological budgets. Ground-based point measurements are unable to describe the full spatial variability of snow accumulation and melt rates, and repeat Unmanned Air Vehicle (UAV) surveys provide an unparalleled opportunity to measure snow accumulation, redistribution and melt in alpine environments. This study presents results from a UAV-based observation campaign conducted at the Fortress Mountain Snow Laboratory in the Canadian Rockies in 2017. Seven survey flights were conducted between April (maximum snow accumulation) and mid-July (bare ground) to collect imagery with both an RGB camera and thermal infrared imager with the sensefly eBee RTK platform. UAV imagery are processed with structure from motion techniques, and orthoimages, digital elevation models, and surface temperature maps are validated against concurrent ground observations of snow depth, snow water equivalent, and snow surface temperature. We examine the seasonal evolution of snow depth and snow surface temperature, and explore the spatial covariances of these variables with respect to topographic factors and snow ablation rates. Our results have direct implications for scaling snow ablation calculations and model resolution and discretization.

Determining Semantically Related Significant Genes.

PubMed

Taha, Kamal

2014-01-01

GO relation embodies some aspects of existence dependency. If GO term xis existence-dependent on GO term y, the presence of y implies the presence of x. Therefore, the genes annotated with the function of the GO term y are usually functionally and semantically related to the genes annotated with the function of the GO term x. A large number of gene set enrichment analysis methods have been developed in recent years for analyzing gene sets enrichment. However, most of these methods overlook the structural dependencies between GO terms in GO graph by not considering the concept of existence dependency. We propose in this paper a biological search engine called RSGSearch that identifies enriched sets of genes annotated with different functions using the concept of existence dependency. We observe that GO term xcannot be existence-dependent on GO term y, if x- and y- have the same specificity (biological characteristics). After encoding into a numeric format the contributions of GO terms annotating target genes to the semantics of their lowest common ancestors (LCAs), RSGSearch uses microarray experiment to identify the most significant LCA that annotates the result genes. We evaluated RSGSearch experimentally and compared it with five gene set enrichment systems. Results showed marked improvement.

Improved Lower Mekong River Basin Hydrological Decision Making Using NASA Satellite-based Earth Observation Systems

NASA Astrophysics Data System (ADS)

Bolten, J. D.; Mohammed, I. N.; Srinivasan, R.; Lakshmi, V.

2017-12-01

Better understanding of the hydrological cycle of the Lower Mekong River Basin (LMRB) and addressing the value-added information of using remote sensing data on the spatial variability of soil moisture over the Mekong Basin is the objective of this work. In this work, we present the development and assessment of the LMRB (drainage area of 495,000 km2) Soil and Water Assessment Tool (SWAT). The coupled model framework presented is part of SERVIR, a joint capacity building venture between NASA and the U.S. Agency for International Development, providing state-of-the-art, satellite-based earth monitoring, imaging and mapping data, geospatial information, predictive models, and science applications to improve environmental decision-making among multiple developing nations. The developed LMRB SWAT model enables the integration of satellite-based daily gridded precipitation, air temperature, digital elevation model, soil texture, and land cover and land use data to drive SWAT model simulations over the Lower Mekong River Basin. The LMRB SWAT model driven by remote sensing climate data was calibrated and verified with observed runoff data at the watershed outlet as well as at multiple sites along the main river course. Another LMRB SWAT model set driven by in-situ climate observations was also calibrated and verified to streamflow data. Simulated soil moisture estimates from the two models were then examined and compared to a downscaled Soil Moisture Active Passive Sensor (SMAP) 36 km radiometer products. Results from this work present a framework for improving SWAT performance by utilizing a downscaled SMAP soil moisture products used for model calibration and validation. Index Terms: 1622: Earth system modeling; 1631: Land/atmosphere interactions; 1800: Hydrology; 1836 Hydrological cycles and budgets; 1840 Hydrometeorology; 1855: Remote sensing; 1866: Soil moisture; 6334: Regional Planning

Cultural significance of primary teeth for caregivers in Northeast Brazil.

PubMed

Nations, Marilyn K; Calvasina, Paola Gondim; Martin, Michele N; Dias, Hilma Fontenele

2008-04-01

This anthropological study critically evaluates Brazilian caregivers' symbolic production and significance of their malnourished offspring's primary teeth, as well as their own, and describes popular dental practices. From January to June 2004, ethnographic interviews of 27 poor, low-literacy mothers were conducted at a public Malnutrition Treatment Center in Fortaleza, Ceará State. Participant observation of clinical pathways and home environments supplemented the data. Content analysis was performed. Results confirm that primary teeth are imbued with cultural significance in Northeast Brazil. Mothers examine mouths, perceive signs of decay, associate primary with permanent tooth healthiness, identify ethnodental illnesses, seek assistance, and perform rituals with exfoliated teeth. The mother's motivation to care for primary teeth is sparked by her memories of past toothache and attempts to avoid stigma and discrimination. Social determinants, not mothers' beliefs or behaviors, are the most critical obstacles to effective dental care. Legitimizing lay knowledge and empowering caregivers and children can improve oral health in Northeast Brazil.

UAS Developments Supporting Wildfire Observations

NASA Astrophysics Data System (ADS)

Ambrosia, V. G.; Dahlgren, R. P.; Watts, A.; Reynolds, K. W.; Ball, T.

2014-12-01

Wildfires are regularly occurring emergency events that threaten life, property, and natural resources in every U.S. State and many countries around the world. Despite projections that $1.8 billion will be spent by U.S. Federal agencies alone on wildfires in 2014, the decades-long trend of increasing fire size, severity, and cost is expected to continue. Furthermore, the enormous potential for UAS (and concomitant sensor systems) to serve as geospatial intelligence tools to improve the safety and effectiveness of fire management, and our ability to forecast fire and smoke movements, remains barely tapped. Although orbital sensor assets are can provide the geospatial extent of wildfires, generally those resources are limited in use due to their spatial and temporal resolution limitations. These two critical elements make orbital assets of limited utility for tactical, real-time wildfire management, or for continuous scientific analysis of the temporal dynamics related to fire energy release rates and plume concentrations that vary significantly thru a fire's progression. Large UAS platforms and sensors can and have been used to monitor wildfire events at improved temporal, spatial and radiometric scales, but more focus is being placed on the use of small UAS (sUAS) and sensors to support wildfire observation strategies. The use of sUAS is therefore more critical for TACTICAL management purposes, rather than strategic observations, where small-scale fire developments are critical to understand. This paper will highlight the historical development and use of UAS for fire observations, as well as the current shift in focus to smaller, more affordable UAS for more rapid integration into operational use on wildfire events to support tactical observation strategies, and support wildfire science measurement inprovements.

The prognostic significance of smoking cessation after acute coronary syndromes: an observational, multicentre study from the Melbourne interventional group registry.

PubMed

Yudi, Matias B; Farouque, Omar; Andrianopoulos, Nick; Ajani, Andrew E; Kalten, Katie; Brennan, Angela L; Lefkovits, Jeffrey; Hiew, Chin; Oqueli, Ernesto; Reid, Christopher M; Duffy, Stephen J; Clark, David J

2017-10-06

We aim to ascertain the prognostic significance of persistent smoking and smoking cessation after an acute coronary syndrome (ACS) in the era of percutaneous coronary intervention (PCI) and optimal secondary prevention pharmacotherapy. Consecutive patients from the Melbourne Interventional Group registry (2005-2013) who were alive at 30 days post-ACS presentation were included in our observational cohort study. Patients were divided into four categories based on their smoking status: non-smoker; ex-smoker (quit >1 month before ACS); recent quitter (smoker at presentation but quit by 30 days) and persistent smoker (smoker at presentation and at 30 days). The primary endpoint was survival ascertained through the Australian National Death Index linkage. A Cox-proportional hazards model was used to estimate the adjusted HR and 95% CI for survival. Of the 9375 patients included, 2728 (29.1%) never smoked, 3712 (39.6%) were ex-smokers, 1612 (17.2%) were recent quitters and 1323 (14.1%) were persistent smokers. Cox-proportional hazard modelling revealed, compared with those who had never smoked, that persistent smoking (HR 1.78, 95% CI 1.36 to 2.32, p<0.001) was an independent predictor of increased hazard (mean follow-up 3.9±2.2 years) while being a recent quitter (HR 1.27, 95% CI 0.96 to 1.68, p=0.10) or an ex-smoker (HR 1.03, 95% CI 0.87 to 1.22, p=0.72) were not. In a contemporary cohort of patients with ACS, those who continued to smoke had an 80% risk of lower survival while those who quit had comparable survival to lifelong non-smokers. This underscores the importance of smoking cessation in secondary prevention despite the improvement in management of ACS with PCI and pharmacotherapy. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Infrared observations of outer planet satellites

NASA Technical Reports Server (NTRS)

Johnson, T. V.

1988-01-01

This task supports IR observations of the outer planet satellites. These data provide vital information about the thermophysical properties of satellite surfaces, including internal heat sources for Io. Observations include both broad and narrow band measurementsin the 2 to 20 micrometer spectral range. The program in the last year has aimed at obtaining lonitude coverage on Io to establish stability of hot spot patterns previously reported. Several runs produced the most complete data set for an apparition since the start of the program. Unfortunately, bad weather limited coverage of key longitude ranges containing the largest known hot spot Loki. Among the preliminary results is the observation of an outburst in Io's thermal flux that was measured at 4.8, 8.7 and 20 micrometer. Analysis of the data has given the best evidence to date of silicate volcanism on Io; this is one of the most significant pieces of the puzzle as to the relative roles of silicate and sulfur volcanism on Io. Researchers are collaborating with J. Goguen (NRC RRA to finish reduction of mutual event data, which have already improved ephermeris information for the satellites. The data appear to place significant limits on the characteristics of any leading side hot spots.

Significant Improvement of Thermal Stability for CeZrPrNd Oxides Simply by Supercritical CO2 Drying

PubMed Central

Fan, Yunzhao; Wang, Zizi; Xin, Ying; Li, Qian; Zhang, Zhaoliang; Wang, Yingxia

2014-01-01

Pr and Nd co-doped Ce-Zr oxide solid solutions (CZPN) were prepared using co-precipitation and microemulsion methods. It is found that only using supercritical CO2 drying can result in a significant improvement of specific surface area and oxygen storage capacity at lower temperatures for CZPN after aging at 1000°C for 12 h in comparison with those using conventional air drying and even supercritical ethanol drying. Furthermore, the cubic structure was obtained in spite of the fact that the atomic ratio of Ce/(Ce+Zr+Pr+Nd) is as low as 29%. The high thermal stability can be attributed to the loosely aggregated morphology and the resultant Ce enrichment on the nanoparticle surface, which are caused by supercritical CO2 drying due to the elimination of surface tension effects on the gas-liquid interface. PMID:24516618

Alignment of an interprofessional student learning experience with a hospital quality improvement initiative.

PubMed

Fowler, Terri O; Wise, Holly H; Mauldin, Mary P; Ragucci, Kelly R; Scheurer, Danielle B; Su, Zemin; Mauldin, Patrick D; Bailey, Jennifer R; Borckardt, Jeffrey J

2018-04-11

Assessment of interprofessional education (IPE) frequently focuses on students' learning outcomes including changes in knowledge, skills, and/or attitudes. While a foundational education in the values and information of their chosen profession is critical, interprofessional learning follows a continuum from formal education to practice. The continuum increases in significance and complexity as learning becomes more relationship based and dependent upon the ability to navigate complex interactions with patients, families, communities, co-workers, and others. Integrating IPE into collaborative practice is critical to enhancing students' experiential learning, developing teamwork competencies, and understanding the complexity of teams. This article describes a project that linked students with a hospital-based quality-improvement effort to focus on the acquisition and practice of teamwork skills and to determine the impact of teamwork on patient and quality outcome measures. A hospital unit was identified with an opportunity for improvement related to quality care, patient satisfaction, employee engagement, and team behaviours. One hundred and thirty-seven students from six health profession colleges at the Medical University of South Carolina underwent TeamSTEPPS® training and demonstrated proficiency of their teamwork-rating skills with the TeamSTEPPS® Team Performance Observation Tool (T-TPO). Students observed real-time team behaviours of unit staff before and after staff attended formal TeamSTEPPS® training. The students collected a total of 778 observations using the T-TPO. Teamwork performance on the unit improved significantly across all T-TPO domains (team structure, communication, leadership, situation monitoring, and mutual support). Significant improvement in each domain continued post-intervention and at 15-month follow-up, improvement remained significant compared to baseline. Student engagement in TeamSTEPPS® training and demonstration of their

Improved gravity anomaly fields from retracked multimission satellite radar altimetry observations over the Persian Gulf and the Caspian Sea

NASA Astrophysics Data System (ADS)

Khaki, M.; Forootan, E.; Sharifi, M. A.; Awange, J.; Kuhn, M.

2015-09-01

Satellite radar altimetry observations are used to derive short wavelength gravity anomaly fields over the Persian Gulf and the Caspian Sea, where in situ and ship-borne gravity measurements have limited spatial coverage. In this study the retracking algorithm `Extrema Retracking' (ExtR) was employed to improve sea surface height (SSH) measurements that are highly biased in the study regions due to land contaminations in the footprints of the satellite altimetry observations. ExtR was applied to the waveforms sampled by the five satellite radar altimetry missions: TOPEX/POSEIDON, JASON-1, JASON-2, GFO and ERS-1. Along-track slopes have been estimated from the improved SSH measurements and used in an iterative process to estimate deflections of the vertical, and subsequently, the desired gravity anomalies. The main steps of the gravity anomaly computations involve estimating improved SSH using the ExtR technique, computing deflections of the vertical from interpolated SSHs on a regular grid using a biharmonic spline interpolation and finally estimating gridded gravity anomalies. A remove-compute-restore algorithm, based on the fast Fourier transform, has been applied to convert deflections of the vertical into gravity anomalies. Finally, spline interpolation has been used to estimate regular gravity anomaly grids over the two study regions. Results were evaluated by comparing the estimated altimetry-derived gravity anomalies (with and without implementing the ExtR algorithm) with ship-borne free air gravity anomaly observations, and free air gravity anomalies from the Earth Gravitational Model 2008 (EGM2008). The comparison indicates a range of 3-5 mGal in the residuals, which were computed by taking the differences between the retracked altimetry-derived gravity anomaly and the ship-borne data. The comparison of retracked data with ship-borne data indicates a range in the root-mean-square-error (RMSE) between approximately 1.8 and 4.4 mGal and a bias between 0

Acute Exercise Improves Motor Memory Consolidation in Preadolescent Children

PubMed Central

Lundbye-Jensen, Jesper; Skriver, Kasper; Nielsen, Jens B.; Roig, Marc

2017-01-01

Objective: The ability to acquire new motor skills is essential both during childhood and later in life. Recent studies have demonstrated that an acute bout of exercise can improve motor memory consolidation in adults. The objective of the present study was to investigate whether acute exercise protocols following motor skill practice in a school setting can also improve long-term retention of motor memory in preadolescent children. Methods: Seventy-seven pre-adolescent children (age 10.5 ± 0.75 (SD)) participated in the study. Prior to the main experiment age, BMI, fitness status and general physical activity level was assessed in all children and they were then randomly allocated to three groups. All children practiced a visuomotor tracking task followed by 20 min of rest (CON), high intensity intermittent floorball (FLB) or running (RUN) with comparable exercise intensity and duration for exercise groups. Delayed retention of motor memory was assessed 1 h, 24 h and 7 days after motor skill acquisition. Results: During skill acquisition, motor performance improved significantly to the immediate retention test with no differences between groups. One hour following skill acquisition, motor performance decreased significantly for RUN. Twenty-four hours following skill acquisition there was a tendency towards improved performance for FLB but no significant effects. Seven days after motor practice however, both FLB and RUN performed better when compared to their immediate retention test indicating significant offline gains. This effect was not observed for CON. In contrast, 7 days after motor practice, retention of motor memory was significantly better for FLB and RUN compared to CON. No differences were observed when comparing FLB and RUN. Conclusions: Acute intense intermittent exercise performed immediately after motor skill acquisition facilitates long-term motor memory in pre-adolescent children, presumably by promoting memory consolidation. The results also

Using multimedia tools and high-fidelity simulations to improve medical students' resuscitation performance: an observational study

PubMed Central

Wang, Candice; Huang, Chin-Chou; Lin, Shing-Jong; Chen, Jaw-Wen

2016-01-01

Objectives The goal of our study was to shed light on educational methods to strengthen medical students' cardiopulmonary resuscitation (CPR) leadership and team skills in order to optimise CPR understanding and success using didactic videos and high-fidelity simulations. Design An observational study. Setting A tertiary medical centre in Northern Taiwan. Participants A total of 104 5–7th year medical students, including 72 men and 32 women. Interventions We provided the medical students with a 2-hour training session on advanced CPR. During each class, we divided the students into 1–2 groups; each group consisted of 4–6 team members. Medical student teams were trained by using either method A or B. Method A started with an instructional CPR video followed by a first CPR simulation. Method B started with a first CPR simulation followed by an instructional CPR video. All students then participated in a second CPR simulation. Outcome measures Student teams were assessed with checklist rating scores in leadership, teamwork and team member skills, global rating scores by an attending physician and video-recording evaluation by 2 independent individuals. Results The 104 medical students were divided into 22 teams. We trained 11 teams using method A and 11 using method B. Total second CPR simulation scores were significantly higher than first CPR simulation scores in leadership (p<0.001), teamwork (p<0.001) and team member skills (p<0.001). For methods A and B students' first CPR simulation scores were similar, but method A students' second CPR simulation scores were significantly higher than those of method B in leadership skills (p=0.034), specifically in the support subcategory (p=0.049). Conclusions Although both teaching strategies improved leadership, teamwork and team member performance, video exposure followed by CPR simulation further increased students' leadership skills compared with CPR simulation followed by video exposure. PMID:27678539

Casimir meets Poisson: improved quark/gluon discrimination with counting observables

DOE PAGES

Frye, Christopher; Larkoski, Andrew J.; Thaler, Jesse; ...

2017-09-19

Charged track multiplicity is among the most powerful observables for discriminating quark- from gluon-initiated jets. Despite its utility, it is not infrared and collinear (IRC) safe, so perturbative calculations are limited to studying the energy evolution of multiplicity moments. While IRC-safe observables, like jet mass, are perturbatively calculable, their distributions often exhibit Casimir scaling, such that their quark/gluon discrimination power is limited by the ratio of quark to gluon color factors. In this paper, we introduce new IRC-safe counting observables whose discrimination performance exceeds that of jet mass and approaches that of track multiplicity. The key observation is that trackmore » multiplicity is approximately Poisson distributed, with more suppressed tails than the Sudakov peak structure from jet mass. By using an iterated version of the soft drop jet grooming algorithm, we can define a “soft drop multiplicity” which is Poisson distributed at leading-logarithmic accuracy. In addition, we calculate the next-to-leading-logarithmic corrections to this Poisson structure. If we allow the soft drop groomer to proceed to the end of the jet branching history, we can define a collinear-unsafe (but still infrared-safe) counting observable. Exploiting the universality of the collinear limit, we define generalized fragmentation functions to study the perturbative energy evolution of collinear-unsafe multiplicity.« less

Casimir meets Poisson: improved quark/gluon discrimination with counting observables

DOE Office of Scientific and Technical Information (OSTI.GOV)

Frye, Christopher; Larkoski, Andrew J.; Thaler, Jesse

Charged track multiplicity is among the most powerful observables for discriminating quark- from gluon-initiated jets. Despite its utility, it is not infrared and collinear (IRC) safe, so perturbative calculations are limited to studying the energy evolution of multiplicity moments. While IRC-safe observables, like jet mass, are perturbatively calculable, their distributions often exhibit Casimir scaling, such that their quark/gluon discrimination power is limited by the ratio of quark to gluon color factors. In this paper, we introduce new IRC-safe counting observables whose discrimination performance exceeds that of jet mass and approaches that of track multiplicity. The key observation is that trackmore » multiplicity is approximately Poisson distributed, with more suppressed tails than the Sudakov peak structure from jet mass. By using an iterated version of the soft drop jet grooming algorithm, we can define a “soft drop multiplicity” which is Poisson distributed at leading-logarithmic accuracy. In addition, we calculate the next-to-leading-logarithmic corrections to this Poisson structure. If we allow the soft drop groomer to proceed to the end of the jet branching history, we can define a collinear-unsafe (but still infrared-safe) counting observable. Exploiting the universality of the collinear limit, we define generalized fragmentation functions to study the perturbative energy evolution of collinear-unsafe multiplicity.« less

IMPROVING NATIONAL AIR QUALITY FORECASTS WITH SATELLITE AEROSOL OBSERVATIONS

EPA Science Inventory

Air quality forecasts for major US metropolitan areas have been provided to the public through a partnership between the US Environmental Protection Agency and state and local air agencies since 1997. Recent years have witnessed improvement in forecast skill and expansion of fore...

Promoting Implementation of Multi-Disciplinary Sustained Ocean Observations

NASA Astrophysics Data System (ADS)

Pearlman, Jay; Bourassa, Mark; Hill, Katherine; Miloslavich, Patricia; Simmons, Samantha; Sloyan, Bernadette; Telszewski, Maciej

2017-04-01

Since the OceanObs'09 Conference, the ocean observing community has been improving coordination and collaboration amongst physical, biogeochemical and biology/ecosystem communities. Societal and scientific requirements for sustained observations are being captured in Essential Ocean Variables (EOVs), many of which are also Essential Climate Variables (ECVs) as defined by the Global Climate Observing System reporting to the UNFCCC. Significant progress has been made through the introduction of the Framework for Ocean Observing in 2012 and the creation and refinement of the disciplinary EOVs, based on expert evaluation of feasibility and impact. With advances in observing technology, and the definition of EOVs, clear opportunities exist to improve the coordinated planning and implementation of observing activities measuring EOVs across the three disciplines of physical, biogeochemical and biology/ecosystem oceanography. In early 2017, a workshop examined priority steps forward with the objectives: • To build on the established societal and scientific requirements expressed in EOVs, identify the key applications and phenomena that will benefit from co-located multi-disciplinary sustained observations • To identify near-term innovation priorities for observing platforms and sensors to enable multi-disciplinary observations, and • To identify programmatic and professional connections between existing and emerging observing networks that will increase multi-disciplinary observations. To support these objectives and to provide a mechanism for looking at convergence across the oceans disciplines, three preselected demonstration themes were defined and discussed: • Changes in plankton communities (including ocean color), • Oxygen minimum zones, • Open ocean/shelf interactions (including boundary currents) These themes were chosen because they represent global and challenging problems that are best addressed through collaboration of physical, biogeochemical and

A Review of New and Developing Technology to Significantly Improve Mars Sample-Return Missions

NASA Technical Reports Server (NTRS)

Carsey, F.; Brophy, J.; Gilmore, M.; Rodgers, D.; Wilcox, B.

2000-01-01

A JPL development activity was initiated in FY 1999 for the purpose of examining and evaluating technologies that could materially improve future (i.e., beyond the 2005 launch) Mars sample return missions. The scope of the technology review was comprehensive and end-to-end; the goal was to improve mass, cost, risk, and scientific return. A specific objective was to assess approaches to sample return with only one Earth launch. While the objective of the study was specifically for sample-return, in-situ missions can also benefit from using many of the technologies examined.

A Review of New and Developing Technology to Significantly Improve Mars Sample-Return Missions

NASA Astrophysics Data System (ADS)

Carsey, F.; Brophy, J.; Gilmore, M.; Rodgers, D.; Wilcox, B.

2000-07-01

A JPL development activity was initiated in FY 1999 for the purpose of examining and evaluating technologies that could materially improve future (i.e., beyond the 2005 launch) Mars sample return missions. The scope of the technology review was comprehensive and end-to-end; the goal was to improve mass, cost, risk, and scientific return. A specific objective was to assess approaches to sample return with only one Earth launch. While the objective of the study was specifically for sample-return, in-situ missions can also benefit from using many of the technologies examined.

Cryptosporidium and other intestinal parasitic infections among HIV patients in southern Ethiopia: significance of improved HIV-related care.

PubMed

Shimelis, Techalew; Tassachew, Yayehyirad; Lambiyo, Tariku

2016-05-10

Intestinal parasitic infections are known to cause gastroenteritis, leading to higher morbidity and mortality, particularly in people living with HIV/AIDS. This study aimed to determine the prevalence of Cryptosporidium and other intestinal parasitic infections among HIV patients receiving care at a hospital in Ethiopia where previous available baseline data helps assess if improved HIV-related care has reduced infection rates. A cross-sectional study was conducted at Hawassa University Hospital in southern Ethiopia from May, 2013 to March, 2014. A consecutive sample of 491 HIV- infected patients with diarrhea or a CD4 T cell count < 200 cells/μl were prospectively studied. A single stool sample was collected from each study participant and processed using direct, formol-ether concentration, and modified Ziehl-Neelsen techniques for the diagnosis of Cryptosporidium and other intestinal parasites. The study was approved by the Institutional Review Board of the College of Medicine and Health Sciences, Hawassa University. Physicians managed participants found to be infected with any pathogenic intestinal parasite. The overall prevalence of intestinal parasitic infections among the study population was 35.8 %. The most prevalent parasites were Cryptosporidium (13.2 %), followed by Entamoeba histolytica/dispar (10.2 %), and Giardia lamblia (7.9 %). The rate of single and multiple infections were 25.5 and 10.3 %, respectively. Patients with a CD4 T cell count < 200 cells/μl had a similar rate of any intestinal parasitic infection or cryptosporidiosis compared to those with counts ≥ 200 cells/μl, but with some type of diarrhea. The study shows high prevalence of intestinal parasitic infections in the study population. However, the results in the current report are significantly lower compared to previous findings in the same hospital. The observed lower infection rate is encouraging and supports the need to strengthen and sustain the existing intervention

Improved staff procedure skills lead to improved managment skills: an observational study in an educational setting.

PubMed

Rüter, Anders; Vikstrom, Tore

2009-01-01

Good staff procedure skills in a management group during incidents and disasters are believed to be a prerequisite for good management of the situation. However, this has not been demonstrated scientifically. Templates for evaluation results from performance indicators during simulation exercises have previously been tested. The aim of this study was to demonstrate the possibility that these indicators can be used as a tool for studying the relationship between good management skills and good staff procedure skills. Good and structured work (staff procedure skills) in a hospital management group during simulation exercises in disaster medicine is related to good and timely decisions (good management skills). Results from 29 consecutive simulation exercises in which staff procedure skills and management skills were evaluated using quantitative measurements were included. The statistical analysis method used was simple linear regression with staff procedure skills as the response variable and management skills as the predictor variable. An overall significant relationship was identified between staff procedure skills and management skills (p(2)0.05). This study suggests that there is a relationship between staff procedure skills and management skills in the educational setting used. Future studies are needed to demonstrate if this also can be observed during actual incidents.

Introduction of e-learning in dental radiology reveals significantly improved results in final examination.

PubMed

Meckfessel, Sandra; Stühmer, Constantin; Bormann, Kai-Hendrik; Kupka, Thomas; Behrends, Marianne; Matthies, Herbert; Vaske, Bernhard; Stiesch, Meike; Gellrich, Nils-Claudius; Rücker, Martin

2011-01-01

Because a traditionally instructed dental radiology lecture course is very time-consuming and labour-intensive, online courseware, including an interactive-learning module, was implemented to support the lectures. The purpose of this study was to evaluate the perceptions of students who have worked with web-based courseware as well as the effect on their results in final examinations. Users (n(3+4)=138) had access to the e-program from any networked computer at any time. Two groups (n(3)=71, n(4)=67) had to pass a final exam after using the e-course. Results were compared with two groups (n(1)=42, n(2)=48) who had studied the same content by attending traditional lectures. In addition a survey of the students was statistically evaluated. Most of the respondents reported a positive attitude towards e-learning and would have appreciated more access to computer-assisted instruction. Two years after initiating the e-course the failure rate in the final examination dropped significantly, from 40% to less than 2%. The very positive response to the e-program and improved test scores demonstrated the effectiveness of our e-course as a learning aid. Interactive modules in step with clinical practice provided learning that is not achieved by traditional teaching methods alone. To what extent staff savings are possible is part of a further study. Copyright © 2010 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Heat storage in forest biomass significantly improves energy balance closure particularly during stable conditions

NASA Astrophysics Data System (ADS)

Lindroth, A.; Mölder, M.; Lagergren, F.

2009-08-01

Temperature measurements in trunks and branches in a mature ca. 100 years-old mixed pine and spruce forest in central Sweden were used to estimate the heat storage in the tree biomass. The estimated heat flux in the sample trees and data on biomass distributions were used to scale up to stand level biomass heat fluxes. The rate of change of sensible and latent heat storage in the air layer below the level of the flux measurements was estimated from air temperature and humidity profile measurements and soil heat flux was estimated from heat flux plates and soil temperature measurements. The fluxes of sensible and latent heat from the forest were measured with an eddy covariance system in a tower. The analysis was made for a two-month period in summer of 1995. The tree biomass heat flux was the largest of the estimated storage components and varied between 40 and -35 W m-2 on summer days with nice weather. Averaged over two months the diurnal maximum of total heat storage was 45 W m-2 and the minimum was -35 W m-2. The soil heat flux and the sensible heat storage in air were out of phase with the biomass flux and they reached maximum values that were about 75% of the maximum of the tree biomass heat storage. The energy balance closure improved significantly when the total heat storage was added to the turbulent fluxes. The slope of a regression line with sum of fluxes and storage as independent and net radiation as dependent variable, increased from 0.86 to 0.95 for half-hourly data and the scatter was also reduced. The most significant finding was, however, that during nights with strongly stable conditions when the sensible heat flux dropped to nearly zero, the total storage matched the net radiation nearly perfectly. Another interesting result was that the mean energy imbalance started to increase when the Richardson number became more negative than ca. -0.1. In fact, the largest energy deficit occurred at maximum instability. Our conclusion is that eddy

Observation of Trapped-Electron Mode Microturbulence in Improved Confinement Reversed-Field Pinch Plasmas

NASA Astrophysics Data System (ADS)

Duff, James R.

This is a dissertation for the completion of a Doctorate of Philosophy in Physics degree granted at the University of Wisconsin-Madison. Density fluctuations in the large-density-gradient region of improved confinement Madison Sym- metric Torus (MST) RFP plasmas exhibit multiple features that are characteristic of the trapped- electron mode (TEM). In fusion relevant plasmas, thermal transport is a key avenue of research in order to achieve a burning plasma. In the reversed field pinch (RFP) magnetic geometry, the dy- namics of conventional plasma discharges are primarily governed by magnetic stochasticity stem- ming from multiple long-wavelength tearing modes, that sustain the RFP discharge but have an adverse effect on the plasma confinement. Using inductive current profile control, these tearing modes are reduced, and global confinement is increased to that expected for comparable tokamak plasma. Under these conditions with certain plasma equilibria, new short-wavelength fluctuations distinct from global tearing modes appear in the spectrum at frequencies f 50 kHz that have normalized perpendicular wavenumbers k⊥rhos ≤ 0.2, and propagate in the electron diamagnetic drift direction. By adjusting the plasma current or the inductive suppression, there are observable variations in the spectral features. They exhibit a critical-gradient threshold, and the fluctuation amplitude increases with a local density gradient dependent parameter. These characteristics are consistent with the predictions of unstable TEMs based on gyrokinetic analysis using the GENE code. This thesis represents the first observation and description of TEM-like instabilities in the RFP geometry.

Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses.

PubMed

Liu, Ruijie; Holik, Aliaksei Z; Su, Shian; Jansz, Natasha; Chen, Kelan; Leong, Huei San; Blewitt, Marnie E; Asselin-Labat, Marie-Liesse; Smyth, Gordon K; Ritchie, Matthew E

2015-09-03

Variations in sample quality are frequently encountered in small RNA-sequencing experiments, and pose a major challenge in a differential expression analysis. Removal of high variation samples reduces noise, but at a cost of reducing power, thus limiting our ability to detect biologically meaningful changes. Similarly, retaining these samples in the analysis may not reveal any statistically significant changes due to the higher noise level. A compromise is to use all available data, but to down-weight the observations from more variable samples. We describe a statistical approach that facilitates this by modelling heterogeneity at both the sample and observational levels as part of the differential expression analysis. At the sample level this is achieved by fitting a log-linear variance model that includes common sample-specific or group-specific parameters that are shared between genes. The estimated sample variance factors are then converted to weights and combined with observational level weights obtained from the mean-variance relationship of the log-counts-per-million using 'voom'. A comprehensive analysis involving both simulations and experimental RNA-sequencing data demonstrates that this strategy leads to a universally more powerful analysis and fewer false discoveries when compared to conventional approaches. This methodology has wide application and is implemented in the open-source 'limma' package. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

U.S. NO₂ trends (2005–2013): EPA air quality system (AQS) data versus improved observations from the Ozone Monitoring Instrument (OMI)

DOE PAGES

Lamsal, Lok N.; Duncan, Bryan N.; Yoshida, Yasuko; ...

2015-06-01

Emissions of nitrogen oxides (NO x) and, subsequently, atmospheric levels of nitrogen dioxide (NO₂) have decreased over the U.S. due to a combination of environmental policies and technological change. Consequently, NO₂ levels have decreased by 30–40% in the last decade. We quantify NO₂ trends (2005–2013) over the U.S. using surface measurements from the U.S. Environmental Protection Agency (EPA) Air Quality System (AQS) and an improved tropospheric NO₂ vertical column density (VCD) data product from the Ozone Monitoring Instrument (OMI) on the Aura satellite.We demonstrate that the current OMI NO₂ algorithm is of sufficient maturity to allow a favorable correspondence ofmore » trends and variations in OMI and AQS data. Our trend model accounts for the non-linear dependence of NO₂ concentration on emissions associated with the seasonal variation of the chemical lifetime, including the change in the amplitude of the seasonal cycle associated with the significant change in NO x emissions that occurred over the last decade. The direct relationship between observations and emissions becomes more robust when one accounts for these non-linear dependencies. We improve the OMI NO₂ standard retrieval algorithm and, subsequently, the data product by using monthly vertical concentration profiles, a required algorithm input, from a high-resolution chemistry and transport model (CTM) simulation with varying emissions (2005-2013). The impact of neglecting the time-dependence of the profiles leads to errors in trend estimation, particularly in regions where emissions have changed substantially. For example, trends calculated from retrievals based on time-dependent profiles offer 18% more instances of significant trends and up to 15% larger total NO₂ reduction versus the results based on profiles for 2005. Using a CTM, we explore the theoretical relation of the trends estimated from NO₂ VCDs to those estimated from ground-level concentrations. The model

U.S. NO₂ trends (2005–2013): EPA air quality system (AQS) data versus improved observations from the Ozone Monitoring Instrument (OMI)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lamsal, Lok N.; Duncan, Bryan N.; Yoshida, Yasuko

Emissions of nitrogen oxides (NO x) and, subsequently, atmospheric levels of nitrogen dioxide (NO₂) have decreased over the U.S. due to a combination of environmental policies and technological change. Consequently, NO₂ levels have decreased by 30–40% in the last decade. We quantify NO₂ trends (2005–2013) over the U.S. using surface measurements from the U.S. Environmental Protection Agency (EPA) Air Quality System (AQS) and an improved tropospheric NO₂ vertical column density (VCD) data product from the Ozone Monitoring Instrument (OMI) on the Aura satellite.We demonstrate that the current OMI NO₂ algorithm is of sufficient maturity to allow a favorable correspondence ofmore » trends and variations in OMI and AQS data. Our trend model accounts for the non-linear dependence of NO₂ concentration on emissions associated with the seasonal variation of the chemical lifetime, including the change in the amplitude of the seasonal cycle associated with the significant change in NO x emissions that occurred over the last decade. The direct relationship between observations and emissions becomes more robust when one accounts for these non-linear dependencies. We improve the OMI NO₂ standard retrieval algorithm and, subsequently, the data product by using monthly vertical concentration profiles, a required algorithm input, from a high-resolution chemistry and transport model (CTM) simulation with varying emissions (2005-2013). The impact of neglecting the time-dependence of the profiles leads to errors in trend estimation, particularly in regions where emissions have changed substantially. For example, trends calculated from retrievals based on time-dependent profiles offer 18% more instances of significant trends and up to 15% larger total NO₂ reduction versus the results based on profiles for 2005. Using a CTM, we explore the theoretical relation of the trends estimated from NO₂ VCDs to those estimated from ground-level concentrations. The model

Targeting Heparin to Collagen within Extracellular Matrix Significantly Reduces Thrombogenicity and Improves Endothelialization of Decellularized Tissues.

PubMed

Jiang, Bin; Suen, Rachel; Wertheim, Jason A; Ameer, Guillermo A

2016-12-12

Thrombosis within small-diameter vascular grafts limits the development of bioartificial, engineered vascular conduits, especially those derived from extracellular matrix (ECM). Here we describe an easy-to-implement strategy to chemically modify vascular ECM by covalently linking a collagen binding peptide (CBP) to heparin to form a heparin derivative (CBP-heparin) that selectively binds a subset of collagens. Modification of ECM with CBP-heparin leads to increased deposition of functional heparin (by ∼7.2-fold measured by glycosaminoglycan composition) and a corresponding reduction in platelet binding (>70%) and whole blood clotting (>80%) onto the ECM. Furthermore, addition of CBP-heparin to the ECM stabilizes long-term endothelial cell attachment to the lumen of ECM-derived vascular conduits, potentially through recruitment of heparin-binding growth factors that ultimately improve the durability of endothelialization in vitro. Overall, our findings provide a simple yet effective method to increase deposition of functional heparin on the surface of ECM-based vascular grafts and thereby minimize thrombogenicity of decellularized tissue, overcoming a significant challenge in tissue engineering of bioartificial vessels and vascularized organs.

Activation of Big Grain1 significantly improves grain size by regulating auxin transport in rice.

PubMed

Liu, Linchuan; Tong, Hongning; Xiao, Yunhua; Che, Ronghui; Xu, Fan; Hu, Bin; Liang, Chengzhen; Chu, Jinfang; Li, Jiayang; Chu, Chengcai

2015-09-01

Grain size is one of the key factors determining grain yield. However, it remains largely unknown how grain size is regulated by developmental signals. Here, we report the identification and characterization of a dominant mutant big grain1 (Bg1-D) that shows an extra-large grain phenotype from our rice T-DNA insertion population. Overexpression of BG1 leads to significantly increased grain size, and the severe lines exhibit obviously perturbed gravitropism. In addition, the mutant has increased sensitivities to both auxin and N-1-naphthylphthalamic acid, an auxin transport inhibitor, whereas knockdown of BG1 results in decreased sensitivities and smaller grains. Moreover, BG1 is specifically induced by auxin treatment, preferentially expresses in the vascular tissue of culms and young panicles, and encodes a novel membrane-localized protein, strongly suggesting its role in regulating auxin transport. Consistent with this finding, the mutant has increased auxin basipetal transport and altered auxin distribution, whereas the knockdown plants have decreased auxin transport. Manipulation of BG1 in both rice and Arabidopsis can enhance plant biomass, seed weight, and yield. Taking these data together, we identify a novel positive regulator of auxin response and transport in a crop plant and demonstrate its role in regulating grain size, thus illuminating a new strategy to improve plant productivity.

Observation

ERIC Educational Resources Information Center

Patell, Hilla

2016-01-01

In order to achieve the goal of observation, preparation of the adult, the observer, is necessary. This preparation, says Hilla Patell, requires us to "have an appreciation of the significance of the child's spontaneous activities and a more thorough understanding of the child's needs." She discusses the growth of both the desire to…

Successful Application of a Canadian Mental Health Curriculum Resource by Usual Classroom Teachers in Significantly and Sustainably Improving Student Mental Health Literacy

PubMed Central

Kutcher, Stan; Wei, Yifeng; Morgan, Catherine

2015-01-01

Objective: To investigate whether the significant and substantive findings from a previous study of youth mental health literacy (MHL) could be replicated using the same methods in another population. Method: We examined the impact of a curriculum resource, the Mental Health and High School Curriculum Guide (The Guide), taught by usual classroom teachers on students’ knowledge and attitudes related to mental health and mental illness in Canadian secondary schools. Survey data were collected before, immediately after, and 2 months after implementation of The Guide by teachers in usual classroom teaching. We conducted paired-sample t tests and calculated the Cohen d value to determine outcomes and impact of the curriculum resource application. Results: One hundred fourteen students were matched for analysis of knowledge data and 112 students were matched for analysis of attitude data at pre-intervention, post-intervention, and 2-month follow-up time periods. Following classroom exposure to the curriculum resource, students’ knowledge scores increased significantly and substantively, compared with baseline (P < 0.001, d = 1.11), and this was maintained at 2-month follow-up (P < 0.001, d = 0.91). Similar findings for attitude improvement were found (P < 0.001, d = 0.66), and this improvement was maintained at 2-month follow-up (P < 0.001, d = 0.52). Conclusions: These findings corroborate those from a previous study conducted in a different location. Taken together these results suggest a simple but effective approach to improving MHL in young people by embedding a classroom resource, delivered by usual classroom teachers in usual school settings. PMID:26720827

Successful Application of a Canadian Mental Health Curriculum Resource by Usual Classroom Teachers in Significantly and Sustainably Improving Student Mental Health Literacy.

PubMed

Kutcher, Stan; Wei, Yifeng; Morgan, Catherine

2015-12-01

To investigate whether the significant and substantive findings from a previous study of youth mental health literacy (MHL) could be replicated using the same methods in another population. We examined the impact of a curriculum resource, the Mental Health and High School Curriculum Guide (The Guide), taught by usual classroom teachers on students' knowledge and attitudes related to mental health and mental illness in Canadian secondary schools. Survey data were collected before, immediately after, and 2 months after implementation of The Guide by teachers in usual classroom teaching. We conducted paired-sample t tests and calculated the Cohen d value to determine outcomes and impact of the curriculum resource application. One hundred fourteen students were matched for analysis of knowledge data and 112 students were matched for analysis of attitude data at pre-intervention, post-intervention, and 2-month follow-up time periods. Following classroom exposure to the curriculum resource, students' knowledge scores increased significantly and substantively, compared with baseline (P < 0.001, d = 1.11), and this was maintained at 2-month follow-up (P < 0.001, d = 0.91). Similar findings for attitude improvement were found (P < 0.001, d = 0.66), and this improvement was maintained at 2-month follow-up (P < 0.001, d = 0.52). These findings corroborate those from a previous study conducted in a different location. Taken together these results suggest a simple but effective approach to improving MHL in young people by embedding a classroom resource, delivered by usual classroom teachers in usual school settings.

Peer observation and feedback of resident teaching.

PubMed

Snydman, Laura; Chandler, Daniel; Rencic, Joseph; Sung, Yung-Chi

2013-02-01

Resident doctors (residents) play a significant role in the education of medical students. Morning work rounds provide an optimal venue to assess resident teaching. The purpose of this study was to assess the feasibility of peer observation of resident work rounds, to evaluate resident perceptions of peer observation and to evaluate resident perceptions of peer feedback.   Twenty-four internal medicine residents were simultaneously observed by an attending physician and a peer while teaching during work rounds (between August2008 and May 2009). At year-end, residents received a survey to characterise their attitudes towards peer observation and feedback. Twenty-one residents (87.5%) completed the survey. Half (52.4%) felt that participating in the peer observation study stimulated their interest in teaching during work rounds. Prior to participation in the study, fewer than half (42.9%) felt comfortable being observed by their peers, compared with 71.4 percent after participation (p=0.02). The proportion of residents who felt comfortable giving feedback to peers increased from 26.3 to 65.0percent (p=0.004), and the proportion of residents who felt comfortable receiving feedback from peers increased from 76.2 to 95.2 percent (p=0.02). Peer observation and feedback of resident teaching during work rounds is feasible and rewarding for the residents involved. Comfort with regards to being observed by peers, with receiving feedback from peers and with giving feedback to peers significantly increased after the study. Most residents reported changes in their teaching behaviour resulting from feedback. Residents felt that observing a peer teach on work rounds was one of the most useful activities to improve their own teaching on work rounds. © Blackwell Publishing Ltd 2013.

Combat-related intradural gunshot wound to the thoracic spine: significant improvement and neurologic recovery following bullet removal.

PubMed

Louwes, Thijs M; Ward, William H; Lee, Kendall H; Freedman, Brett A

2015-02-01

The vast majority of combat-related penetrating spinal injuries from gunshot wounds result in severe or complete neurological deficit. Treatment is based on neurological status, the presence of cerebrospinal fluid (CSF) fistulas, and local effects of any retained fragment(s). We present a case of a 46-year-old male who sustained a spinal gunshot injury from a 7.62-mm AK-47 round that became lodged within the subarachnoid space at T9-T10. He immediately suffered complete motor and sensory loss. By 24-48 hours post-injury, he had recovered lower extremity motor function fully but continued to have severe sensory loss (posterior cord syndrome). On post-injury day 2, he was evacuated from the combat theater and underwent a T9 laminectomy, extraction of the bullet, and dural laceration repair. At surgery, the traumatic durotomy was widened and the bullet, which was laying on the dorsal surface of the spinal cord, was removed. The dura was closed in a water-tight fashion and fibrin glue was applied. Postoperatively, the patient made a significant but incomplete neurological recovery. His stocking-pattern numbness and sub-umbilical searing dysthesia improved. The spinal canal was clear of the foreign body and he had no persistent CSF leak. Postoperative magnetic resonance imaging of the spine revealed contusion of the spinal cord at the T9 level. Early removal of an intra-canicular bullet in the setting of an incomplete spinal cord injury can lead to significant neurological recovery following even high-velocity and/or high-caliber gunshot wounds. However, this case does not speak to, and prior experience does not demonstrate, significant neurological benefit in the setting of a complete injury.

Combat-Related Intradural Gunshot Wound to the Thoracic Spine: Significant Improvement and Neurologic Recovery Following Bullet Removal

PubMed Central

Louwes, Thijs M; Ward, William H; Lee, Kendall H

2015-01-01

The vast majority of combat-related penetrating spinal injuries from gunshot wounds result in severe or complete neurological deficit. Treatment is based on neurological status, the presence of cerebrospinal fluid (CSF) fistulas, and local effects of any retained fragment(s). We present a case of a 46-year-old male who sustained a spinal gunshot injury from a 7.62-mm AK-47 round that became lodged within the subarachnoid space at T9-T10. He immediately suffered complete motor and sensory loss. By 24-48 hours post-injury, he had recovered lower extremity motor function fully but continued to have severe sensory loss (posterior cord syndrome). On post-injury day 2, he was evacuated from the combat theater and underwent a T9 laminectomy, extraction of the bullet, and dural laceration repair. At surgery, the traumatic durotomy was widened and the bullet, which was laying on the dorsal surface of the spinal cord, was removed. The dura was closed in a water-tight fashion and fibrin glue was applied. Postoperatively, the patient made a significant but incomplete neurological recovery. His stocking-pattern numbness and sub-umbilical searing dysthesia improved. The spinal canal was clear of the foreign body and he had no persistent CSF leak. Postoperative magnetic resonance imaging of the spine revealed contusion of the spinal cord at the T9 level. Early removal of an intra-canicular bullet in the setting of an incomplete spinal cord injury can lead to significant neurological recovery following even high-velocity and/or high-caliber gunshot wounds. However, this case does not speak to, and prior experience does not demonstrate, significant neurological benefit in the setting of a complete injury. PMID:25705346

A method to improve observations of gamma-ray sources near 10 (15) eV

NASA Technical Reports Server (NTRS)

Sommers, P.; Elbert, J. W.

1985-01-01

Now that sources of gamma rays near 10 to the 15th power eV have been identified, there is a need for telescopes which can study in detail the high energy gamma ray emissions from these sources. The capabilities of a Cerenkov detector which can track a source at large zenith angle (small elevation angle) are analyzed. Because the observed showers must then develop far from the detector, the effective detection area is very large. During a single half-hour hot phase of Cygnus X-3, for example, it may be possible to detect 45 signal showers compared with 10 background showers. Time structure within the hot phase may then be discernible. The precise capabilities of the detector depend on its mirror size, angular acceptance, electronic speed, coincidence properties, etc. Calculations are presented for one feasible design using mirrors of an improved Fly's Eye type.

Improving trend in ventricular fibrillation/pulseless ventricular tachycardia out-of-hospital cardiac arrest in Rochester, Minnesota: A 26-year observational study from 1991 to 2016.

PubMed

Okubo, Masashi; Atkinson, Elizabeth J; Hess, Erik P; White, Roger D

2017-11-01

Mortality from out-of-hospital cardiac arrest (OHCA) is characterized by substantial regional variation. The Institute of Medicine (IOM) recently recommended enhancing the capabilities of EMS systems to improve outcome. In this study, we analyzed the trend in outcome from ventricular fibrillation/pulseless ventricular tachycardia (VF/pVT) OHCA in Rochester, MN. Survival from these forms of arrest is commonly employed as a benchmark of Emergency Medical Services (EMS) system performance. Using a population-based Utstein-style registry in Rochester, MN where a first responder early defibrillation system is utilized, we evaluated outcome from all EMS-treated VF/pVT arrests and the subgroup of bystander-witnessed VF/pVT from 1991 to 2016. Outcome measurement was neurologically intact survival to discharge, defined as Cerebral Performance Category (CPC) 1 or 2. We divided the 26-year study into three periods: 1991-1997, 1998-2008, and 2009-2016, based on initiation of the first responder system of police officers in 1991 and fire-rescue personnel in 1998, and the latter period for comparison with our previous report in 2009. We observed 355 all VF/pVT arrests and 292 bystander-witnessed VF/pVT arrests between 1991 and 2016. In 2009-2016, neurologically intact survival to discharge from overall VF/pVT and bystander-witnessed VF/pVT increased to 53.7% and 65.2%, respectively, compared with 39.5% and 43.4% in 1991-1997. Using multivariable analysis, survival significantly increased in 2009-2016 among all VF/pVT arrests (adjusted OR, 3.10; 95% CI, 1.54-6.40) and bystander-witnessed VF/pVT (adjusted OR, 4.28; 95% CI, 2.01-9.50), compared with those in 1991-1997. We observed a significant improving secular trend in neurologically intact survival from VF/pVT cardiac arrests with a relatively high recent survival rate in this EMS System. Copyright © 2017 Elsevier B.V. All rights reserved.

The Significance of HIV ‘Blips’ in Resource-Limited Settings: Is It the Same? Analysis of the Treat Asia HIV Observational Database (TAHOD) and the Australian HIV Observational Database (AHOD)

PubMed Central

Kanapathipillai, Rupa; McManus, Hamish; Kamarulzaman, Adeeba; Lim, Poh Lian; Templeton, David J.; Law, Matthew; Woolley, Ian

2014-01-01

Introduction Magnitude and frequency of HIV viral load blips in resource-limited settings, has not previously been assessed. This study was undertaken in a cohort from a high income country (Australia) known as AHOD (Australian HIV Observational Database) and another cohort from a mixture of Asian countries of varying national income per capita, TAHOD (TREAT Asia HIV Observational Database). Methods Blips were defined as detectable VL (≥ 50 copies/mL) preceded and followed by undetectable VL (<50 copies/mL). Virological failure (VF) was defined as two consecutive VL ≥50 copies/ml. Cox proportional hazard models of time to first VF after entry, were developed. Results 5040 patients (AHOD n = 2597 and TAHOD n = 2521) were included; 910 (18%) of patients experienced blips. 744 (21%) and 166 (11%) of high- and middle/low-income participants, respectively, experienced blips ever. 711 (14%) experienced blips prior to virological failure. 559 (16%) and 152 (10%) of high- and middle/low-income participants, respectively, experienced blips prior to virological failure. VL testing occurred at a median frequency of 175 and 91 days in middle/low- and high-income sites, respectively. Longer time to VF occurred in middle/low income sites, compared with high-income sites (adjusted hazards ratio (AHR) 0.41; p<0.001), adjusted for year of first cART, Hepatitis C co-infection, cART regimen, and prior blips. Prior blips were not a significant predictor of VF in univariate analysis (AHR 0.97, p = 0.82). Differing magnitudes of blips were not significant in univariate analyses as predictors of virological failure (p = 0.360 for blip 50–≤1000, p = 0.309 for blip 50–≤400 and p = 0.300 for blip 50–≤200). 209 of 866 (24%) patients were switched to an alternate regimen in the setting of a blip. Conclusion Despite a lower proportion of blips occurring in low/middle-income settings, no significant difference was found between settings. Nonetheless, a

Observing Galaxy Mergers in Simulations

NASA Astrophysics Data System (ADS)

Snyder, Gregory

2018-01-01

I will describe results on mergers and morphology of distant galaxies. By mock-observing 3D cosmological simulations, we aim to contrast theory with data, design better diagnostics of physical processes, and examine unexpected signatures of galaxy formation. Recently, we conducted mock surveys of the Illustris Simulations to learn how mergers would appear in deep HST and JWST surveys. With this approach, we reconciled merger rates estimated using observed close galaxy pairs with intrinsic merger rates predicted by theory. This implies that the merger-pair observability time is probably shorter in the early universe, and therefore that major mergers are more common than implied by the simplest arguments. Further, we show that disturbance-based diagnostics of late-stage mergers can be improved significantly by combining multi-dimensional image information with simulated merger identifications to train automated classifiers. We then apply these classifiers to real measurements from the CANDELS fields, recovering a merger fraction increasing with redshift in broad agreement with pair fractions and simulations, and with statistical errors smaller by a factor of two than classical morphology estimators. This emphasizes the importance of using robust training sets, including cosmological simulations and multidimensional data, for interpreting observed processes in galaxy evolution.

Educational Intervention Improves Compliance With AAN Guidelines for Return Epilepsy Visits: A Quality Improvement Project.

PubMed

Nelson, Gary R; Filloux, Francis M; Kerr, Lynne M

2016-10-01

In 2011, the American Academy of Neurology (AAN) released guidelines for return seizure visits detailing 8 points that should be addressed during such visits. These guidelines are designed to improve routine follow-up care for epilepsy patients. The authors performed a quality improvement project aimed at increasing compliance with these guidelines after educating providers about them. The authors performed a chart review before and after an intervention which included: education regarding the guidelines, providing materials to remind providers of the guidelines, and templates to facilitate compliance. The authors reviewed charts at 2 and 6 months after the intervention. Significant improvement in documentation of 4 of the 8 measures was observed after this educational intervention. This suggests that simple educational interventions may help providers change practice and can improve compliance with new guidelines while requiring minimal time and resources to implement. © The Author(s) 2016.

Sleeve gastrectomy with ileal transposition (SGIT) induces a significant weight loss and diabetes improvement without exclusion of the proximal intestine.

PubMed

Boza, Camilo; Muñoz, Rodrigo; Yung, Elliot; Milone, Luca; Gagner, Michel

2011-06-01

Current effective bariatric procedures such as gastric bypass generate a duodenal-jejunal exclusion, which has been implicated in the resolution of type 2 diabetes. The aim of this study was to test the hypothesis that sleeve gastrectomy with ileal transposition (SGIT), a new procedure, is as effective as Roux-en-Y gastric bypass (RYGB) to induce glucose control on an obese rat model of type 2 diabetes mellitus. Twenty eight obese diabetic Zucker rats, weighing 571 ± 151 g were assigned into three procedures: SGIT (n = 11), RYGB (n = 7), and sham operation (n = 10). Animals were followed, evaluating weekly weight increase and food intake. We performed an insulin tolerance test after 8 weeks and measured serum peptide tyrosine-tyrosine (PYY 3-36) and ghrelin levels. Nine weeks after surgery, sham-operated animals increased their body weight by 24%. In far contrast, SGIT and RYGB rats weighed 21% and 18% less than sham animals, respectively (sham, 884 ± 15 g; SGIT, 720 ± 19 g; RYGB, 754 ± 14 g; p < 0.001). No significant differences were found between SGIT and RYGB. Cumulative food intake in SGIT and RYGB procedures decreased by 29.6% and 32.9%, respectively (sham, 576.3 ± 33 g; SGIT, 405.8 ± 10 g; RYGB, 386.4 ± 21 g; p < 0.001). No differences were found between SGIT and RYGB rats. Sixty minutes after oral gavage, PYY levels were increased by 185% and 74% in SGIT and RYGB, respectively (sham, 63.4 ± 2.1 pg/ml; SGIT, 192.7 ± 17 pg/ml; RYGB, 117.7 ± 4.8 pg/ml; p < 0.001). Glucose tolerance was improved after SGIT and RYGB surgery demonstrated by area under the curve analysis (sham, 27,090 ± 1,424; SGIT, 17,704 ± 1,288 mg/dl; p < 0.018; RYGB, 16,212 ± 2,522; p < 0.01). SGIT proved to be as effective as RYGB on obese diabetic rats as a weight loss procedure. Also, glucose homeostasis improved in SGIT, similar to RYGB, in spite of the absence of duodenal-jejunal exclusion

Public Health Significance of Neuroticism

PubMed Central

Lahey, Benjamin B.

2009-01-01

The personality trait of neuroticism refers to relatively stable tendencies to respond with negative emotions to threat, frustration, or loss. Individuals in the population vary markedly on this trait, ranging from frequent and intense emotional reactions to minor challenges to little emotional reaction even in the face of significant difficulties. Although not widely appreciated, there is growing evidence that neuroticism is a psychological trait of profound public health significance. Neuroticism is a robust correlate and predictor of many different mental and physical disorders, comorbidity among them, and the frequency of mental and general health service use. Indeed, neuroticism apparently is a predictor of the quality and longevity of our lives. Achieving a full understanding of the nature and origins of neuroticism, and the mechanisms through which neuroticism is linked to mental and physical disorders, should be a top priority for research. Knowing why neuroticism predicts such a wide variety of seemingly diverse outcomes should lead to improved understanding of commonalities among those outcomes and improved strategies for preventing them. PMID:19449983

Improvement of Accuracy of Proper Motions of Hipparcos Catalogue Stars Using Optical Latitude Observations

NASA Astrophysics Data System (ADS)

Damljanovic, G.

2009-09-01

), Mizusawa (MZL FZT), Tuorla -- Turku (TT VZT), Mizusawa (MZP and MZQ PZT), Mount Stromlo (MS PZT), Ondřejov (OJP PZT), Punta Indio (PIP PZT), Richmond (RCP and RCQ PZT) and Washington (WA, W and WGQ PZT). The task is to improve the proper motions in declination of the observed Hipparcos stars. The original method was developed, and it consists of removing from the instantaneous observed latitudes all known effects (polar motion and some local instrumental errors). The corrected latitudes are then used to calculate the corrections of the Hipparcos proper motions in declination (Damljanović 2005). The Least Squares Method (LSM) is used with the linear model. We compared the calculated results with ARIHIP and EOC-2 data, and found a good agreement. The newly obtained values of proper motions in declination are substantially more precise than those of the Hipparcos Catalogue. It is because the time interval covered by the latitude observations (tens of years) is much longer than the Hipparcos one (less than four years), and because of the great number of observations made during this interval (Damljanović et al. 2006). Our method is completely different from the one used to compute the EOC-2 catalogue (Vondrák 2004). It was also an almost independent check of the proper motions of EOC-2. The catalogue EOC-2 is used in this thesis to distinguish the corrections of the two stars of a pair observed by using the Horrebow -- Talcott method. The difference between the two proper motions is constrained by the difference in the EOC-2 and Hipparcos catalogues (Damljanović and Pejović 2006). The main result of the thesis is the catalogue of proper motions in declination of 2347 Hipparcos stars.

HEALTH SIGNIFICANCE OF PULMONARY FUNCTION TESTS

EPA Science Inventory

As the sensitivity and precision of functional tests improves, we become increasingly able to measure responses to pollutant exposures with little, if any, demonstrable health significance. Proper interpretation of such functional responses generally requires an ability to evalua...

Emergency Department Expansion Versus Patient Flow Improvement: Impact on Patient Experience of Care.

PubMed

Sayah, Assaad; Lai-Becker, Melisa; Kingsley-Rocker, Lisa; Scott-Long, Tasha; O'Connor, Kelly; Lobon, Luis F

2016-02-01

Most strategies used to help improve the patient experience of care and ease emergency department (ED) crowding and diversion require additional space and personnel resources, major process improvement interventions, or a combination of both. To compare the impact of ED expansion vs. patient flow improvement and the establishment of a rapid assessment unit (RAU) on the patient experience of care in a medium-size safety net ED. This paper describes a study of a single ED wherein the department first undertook a physical expansion (2006 Q2 to 2007 Q2) followed by a reorganization of patient flow and establishment of an RAU (2009 Q2) by the use of an interrupted time series analysis. In the time period after ED expansion, significant negative trends were observed: decreasing Press Ganey percentiles (-4.1 percentile per quarter), increasing door-to-provider time (+4.9 minutes per quarter), increasing duration of stay (+13.2 minutes per quarter), and increasing percent of patients leaving without being seen (+0.11 per quarter). After the RAU was established, significant immediate impacts were observed for door-to-provider time (-25.8 minutes) and total duration of stay (-66.8 minutes). The trends for these indicators further suggested the improvements continued to be significant over time. Furthermore, the negative trends for the Press Ganey outcomes observed after ED expansion were significantly reversed and in the positive direction after the RAU. Our results demonstrate that the impact of process improvement and rapid assessment implementation is far greater than the impact of renovation and facility expansion. Copyright © 2016 Elsevier Inc. All rights reserved.

Current systematic carbon-cycle observations and the need for implementing a policy-relevant carbon observing system

Treesearch

P. Ciais; A. J. Dolman; A. Bombelli; R. Duren; A. Peregon; P. J. Rayner; C. Miller; N. Gobron; G. Kinderman; G. Marland; N. Gruber; F. Chevallier; R. J. Andres; G. Balsamo; L. Bopp; F.-M. Bréon; G. Broquet; R. Dargaville; T. J. Battin; A. Borges; H. Bovensmann; M. Buchwitz; J. Butler; J. G. Canadell; R. B. Cook; R. DeFries; R. Engelen; K. R. Gurney; C. Heinze; M. Heimann; A. Held; M. Henry; B. Law; S. Luyssaert; J. Miller; T. Moriyama; C. Moulin; R. B. Myneni; C. Nussli; M. Obersteiner; D. Ojima; Y. Pan; J.-D. Paris; S. L. Piao; B. Poulter; S. Plummer; S. Quegan; P. Raymond; M. Reichstein; L. Rivier; C. Sabine; D. Schimel; O. Tarasova; R. Valentini; R. Wang; G. van der Werf; D. Wickland; M. Williams; C. Zehner

2014-01-01

A globally integrated carbon observation and analysis system is needed to improve the fundamental understanding of the global carbon cycle, to improve our ability to project future changes, and to verify the effectiveness of policies aiming to reduce greenhouse gas emissions and increase carbon sequestration. Building an integrated carbon observation system requires...

Shared Platform for South African Earth and Environmental Observation Systems: Recent Developments and Improvements

NASA Astrophysics Data System (ADS)

Hugo, Wim

2013-04-01

Over the past 3 years, SAEON has worked with a number of stakeholders and funders to establish a shared platform for the management of dissemination of E&EO research outputs, data sets, and services. This platform is strongly aligned with GEO principles and architecture, allowing direct integration with the GEOSS Broker. The platform has two important characteristics: 1. It reduces the cost and lead time of provision of similar infrastructure for future initiatives. 2. The platform is domain-agnostic to some degree, and can be used for non E&EO applications. Projects to achive this is under way at present. The paper describes the application of the platform for a variety of user communities and initiatives (SAEON Data Portal, South African Earth Observation System, Risk and Vulnerability Atlas, BioEnergy Atlas, National Spatial Information Framework, ICSU World Data System Components, and many more), and demonstrates use cases utilising a distributed, service oriented architecture. Significant improvements have been made to the interoperability functions available to end users and content providers, and these are demonstrated and discussed in detail. Functions include • Creation and persistence of composite maps, as well as time series or scatter charts, supporting a variety of standardized data sources. • Search facilities have been extended to allow analysis and filtering of primary search results, and to deal with large meta-data collections. • In addition, data sources, data listings, news items, images, search results, and other platform content can, with increasing flexibility, be accessed as standardized services that are processed in standardized clients, allowing creation of a rich user interface, and permitting the inclusion of platform functionality into external websites and resources. This shift to explicit service-oriented, peer-to-peer architecture is a preparation for increased distributed processing and content composition, and will support

Improvement to microphysical schemes in WRF Model based on observed data, part I: size distribution function

NASA Astrophysics Data System (ADS)

Shan, Y.; Eric, W.; Gao, L.; Zhao, T.; Yin, Y.

2015-12-01

In this study, we have evaluated the performance of size distribution functions (SDF) with 2- and 3-moments in fitting the observed size distribution of rain droplets at three different heights. The goal is to improve the microphysics schemes in meso-scale models, such as Weather Research and Forecast (WRF). Rain droplets were observed during eight periods of different rain types at three stations on the Yellow Mountain in East China. The SDF in this study were M-P distribution with a fixed shape parameter in Gamma SDF(FSP). Where the Gamma SDFs were obtained with three diagnosis methods with the shape parameters based on Milbrandt (2010; denoted DSPM10), Milbrandt (2005; denoted DSPM05) and Seifert (2008; denoted DSPS08) for solving the shape parameter(SSP) and Lognormal SDF. Based on the preliminary experiments, three ensemble methods deciding Gamma SDF was also developed and assessed. The magnitude of average relative error caused by applying a FSP was 10-2 for fitting 0-order moment of the observed rain droplet distribution, and the magnitude of average relative error changed to 10-1 and 100 respectively for 1-4 order moments and 5-6 order moments. To different extent, DSPM10, DSPM05, DSPS08, SSP and ensemble methods could improve fitting accuracies for 0-6 order moments, especially the one coupling SSP and DSPS08 methods, which provided a average relative error 6.46% for 1-4 order moments and 11.90% for 5-6 order moments, respectively. The relative error of fitting three moments using the Lognormal SDF was much larger than that of Gamma SDF. The threshold value of shape parameter ranged from 0 to 8, because values beyond this range could cause overflow in the calculation. When average diameter of rain droplets was less than 2mm, the possibility of unavailable shape parameter value(USPV) increased with a decreasing droplet size. There was strong sensitivity of moment group in fitting accuracy. When ensemble method coupling SSP and DSPS08 was used, a better fit

Improved Surface Parameter Retrievals using AIRS/AMSU Data

NASA Technical Reports Server (NTRS)

Susskind, Joel; Blaisdell, John

2008-01-01

The AIRS Science Team Version 5.0 retrieval algorithm became operational at the Goddard DAAC in July 2007 generating near real-time products from analysis of AIRS/AMSU sounding data. This algorithm contains many significant theoretical advances over the AIRS Science Team Version 4.0 retrieval algorithm used previously. Two very significant developments of Version 5 are: 1) the development and implementation of an improved Radiative Transfer Algorithm (RTA) which allows for accurate treatment of non-Local Thermodynamic Equilibrium (non-LTE) effects on shortwave sounding channels; and 2) the development of methodology to obtain very accurate case by case product error estimates which are in turn used for quality control. These theoretical improvements taken together enabled a new methodology to be developed which further improves soundings in partially cloudy conditions. In this methodology, longwave C02 channel observations in the spectral region 700 cm(exp -1) to 750 cm(exp -1) are used exclusively for cloud clearing purposes, while shortwave C02 channels in the spectral region 2195 cm(exp -1) 2395 cm(exp -1) are used for temperature sounding purposes. This allows for accurate temperature soundings under more difficult cloud conditions. This paper further improves on the methodology used in Version 5 to derive surface skin temperature and surface spectral emissivity from AIRS/AMSU observations. Now, following the approach used to improve tropospheric temperature profiles, surface skin temperature is also derived using only shortwave window channels. This produces improved surface parameters, both day and night, compared to what was obtained in Version 5. These in turn result in improved boundary layer temperatures and retrieved total O3 burden.

Do gravity waves significantly impact PSC occurrence in the Antarctic?

NASA Astrophysics Data System (ADS)

McDonald, A. J.; George, S. E.; Woollands, R. M.

2009-02-01

This study uses a combination of POAM III aerosol extinction measurements and CHAMP GPS/RO temperature measurements to examine the role of atmospheric gravity waves in Polar Stratospheric Cloud (PSC) formation in the Antarctic. POAM III aerosol extinction observations are used to identify Type I Polar Stratospheric Clouds using an unsupervised clustering algorithm. The seasonal and spatial distribution of PSCs observed by POAM III is examined to determine whether there is a bias towards regions of high wave activity early in the Antarctic winter which may enhance PSC formation. Examination of the probability of temperatures below the Type Ia formation temperature threshold based on UKMO analyses displays a good correspondence to the PSC occurrence derived from POAM III extinction data in general. However, in June the POAM III observations of PSC are more abundant than expected from temperature thresholds. In addition the PSC occurrence based on temperature thresholds in September and October is often significantly higher than the PSC occurrence observed by POAM III, this observation probably being due to dehydration and denitrification. Use of high resolution temperatures from CHAMP GPS/RO observations provide a slightly improved relationship to the POAM III derived values. Analysis of the CHAMP temperature observations indicates that temperature perturbations associated with gravity waves may explain the enhanced PSC incidence observed in June compared to the UKMO analyses. Comparison of the UKMO analyses temperatures relative to corresponding CHAMP observations also suggests a small warm bias in the UKMO analyses during June. Examination of the longitudinal structure PSC occurrence in June 2005 also shows that regions of enhancement are associated with data near the Antarctic peninsula a known Mountain wave "hotspot". The impact of temperature perturbations causing enhanced temperature threshold crossings is shown to be particularly important early in the

Improving UK Air Quality Modelling Through Exploitation of Satellite Observations

NASA Astrophysics Data System (ADS)

Pope, Richard; Chipperfield, Martyn; Savage, Nick

2014-05-01

In this work the applicability of satellite observations to evaluate the operational UK Met Office Air Quality in the Unified Model (AQUM) have been investigated. The main focus involved the AQUM validation against satellite observations, investigation of satellite retrieval error types and of synoptic meteorological-atmospheric chemistry relationships simulated/seen by the AQUM/satellite. The AQUM is a short range forecast model of atmospheric chemistry and aerosols up to 5 days. It has been designed to predict potentially hazardous air pollution events, e.g. high concentrations of surface ozone. The AQUM has only been validated against UK atmospheric chemistry recording surface stations. Therefore, satellite observations of atmospheric chemistry have been used to further validate the model, taking advantage of better satellite spatial coverage. Observations of summer and winter 2006 tropospheric column NO2 from both OMI and SCIAMACHY show that the AQUM generally compares well with the observations. However, in northern England positive biases (AQUM - satellite) suggest that the AQUM overestimates column NO2; we present results of sensitivity experiments on UK emissions datasets suspected to be the cause. In winter, the AQUM over predicts background column NO2 when compared to both satellite instruments. We hypothesise that the cause is the AQUM winter night-time chemistry, where the NO2 sinks are not substantially defined. Satellite data are prone to errors/uncertainty such as random, systematic and smoothing errors. We have investigated these error types and developed an algorithm to calculate and reduce the random error component of DOAS NO2 retrievals, giving more robust seasonal satellite composites. The Lamb Weather Types (LWT), an objective method of classifying the daily synoptic weather over the UK, were used to create composite satellite maps of column NO2 under different synoptic conditions. Under cyclonic conditions, satellite observed UK column NO2 is

Improved VAS regression soundings of mesoscale temperature structure observed during the 1982 atmospheric variability experiment

NASA Technical Reports Server (NTRS)

Chesters, Dennis; Keyser, Dennis A.; Larko, David E.; Uccellini, Louis W.

1987-01-01

An Atmospheric Variability Experiment (AVE) was conducted over the central U.S. in the spring of 1982, collecting radiosonde date to verify mesoscale soundings from the VISSR Atmospheric Sounder (VAS) on the GOES satellite. Previously published VAS/AVE comparisons for the 6 March 1982 case found that the satellite retrievals scarcely detected a low level temperature inversion or a mid-tropospheric cold pool over a special mesoscale radiosonde verification network in north central Texas. The previously published regression and physical retrieval algorithms did not fully utilize VAS' sensitivity to important subsynoptic thermal features. Therefore, the 6 March 1982 case was reprocessed adding two enhancements to the VAS regression retrieval algorithm: (1) the regression matrix was determined using AVE profile data obtained in the region at asynoptic times, and (2) more optimistic signal-to-noise statistical conditioning factors were applied to the VAS temperature sounding channels. The new VAS soundings resolve more of the low level temperature inversion and mid-level cold pool. Most of the improvements stems from the utilization of asynoptic radiosonde observations at NWS sites. This case suggests that VAS regression soundings may require a ground-based asynoptic profiler network to bridge the gap between the synoptic radiosonde network and the high resolution geosynchronous satellite observations during the day.

Significantly improved photovoltaic performance in polymer bulk heterojunction solar cells with graphene oxide /PEDOT:PSS double decked hole transport layer.

PubMed

Rafique, Saqib; Abdullah, Shahino Mah; Shahid, Muhammad Mehmood; Ansari, Mohammad Omaish; Sulaiman, Khaulah

2017-01-13

This work demonstrates the high performance graphene oxide (GO)/PEDOT:PSS doubled decked hole transport layer (HTL) in the PCDTBT:PC 71 BM based bulk heterojunction organic photovoltaic device. The devices were tested on merits of their power conversion efficiency (PCE), reproducibility, stability and further compared with the devices with individual GO or PEDOT:PSS HTLs. Solar cells employing GO/PEDOT:PSS HTL yielded a PCE of 4.28% as compared to either of individual GO or PEDOT:PSS HTLs where they demonstrated PCEs of 2.77 and 3.57%, respectively. In case of single GO HTL, an inhomogeneous coating of ITO caused the poor performance whereas PEDOT:PSS is known to be hygroscopic and acidic which upon direct contact with ITO reduced the device performance. The improvement in the photovoltaic performance is mainly ascribed to the increased charge carriers mobility, short circuit current, open circuit voltage, fill factor, and decreased series resistance. The well matched work function of GO and PEDOT:PSS is likely to facilitate the charge transportation and an overall reduction in the series resistance. Moreover, GO could effectively block the electrons due to its large band-gap of ~3.6 eV, leading to an increased shunt resistance. In addition, we also observed the improvement in the reproducibility and stability.

Significantly improved photovoltaic performance in polymer bulk heterojunction solar cells with graphene oxide /PEDOT:PSS double decked hole transport layer

NASA Astrophysics Data System (ADS)

Rafique, Saqib; Abdullah, Shahino Mah; Shahid, Muhammad Mehmood; Ansari, Mohammad Omaish; Sulaiman, Khaulah

2017-01-01

This work demonstrates the high performance graphene oxide (GO)/PEDOT:PSS doubled decked hole transport layer (HTL) in the PCDTBT:PC71BM based bulk heterojunction organic photovoltaic device. The devices were tested on merits of their power conversion efficiency (PCE), reproducibility, stability and further compared with the devices with individual GO or PEDOT:PSS HTLs. Solar cells employing GO/PEDOT:PSS HTL yielded a PCE of 4.28% as compared to either of individual GO or PEDOT:PSS HTLs where they demonstrated PCEs of 2.77 and 3.57%, respectively. In case of single GO HTL, an inhomogeneous coating of ITO caused the poor performance whereas PEDOT:PSS is known to be hygroscopic and acidic which upon direct contact with ITO reduced the device performance. The improvement in the photovoltaic performance is mainly ascribed to the increased charge carriers mobility, short circuit current, open circuit voltage, fill factor, and decreased series resistance. The well matched work function of GO and PEDOT:PSS is likely to facilitate the charge transportation and an overall reduction in the series resistance. Moreover, GO could effectively block the electrons due to its large band-gap of ~3.6 eV, leading to an increased shunt resistance. In addition, we also observed the improvement in the reproducibility and stability.

Action observation has a positive impact on rehabilitation of motor deficits after stroke.

PubMed

Ertelt, Denis; Small, Steven; Solodkin, Ana; Dettmers, Christian; McNamara, Adam; Binkofski, Ferdinand; Buccino, Giovanni

2007-01-01

Evidence exists that the observation of actions activates the same cortical motor areas that are involved in the performance of the observed actions. The neural substrate for this is the mirror neuron system. We harness this neuronal system and its ability to re-enact stored motor representations as a means for rehabilitating motor control. We combined observation of daily actions with concomitant physical training of the observed actions in a new neurorehabilitative program (action observation therapy). Eight stroke patients with moderate, chronic motor deficit of the upper limb as a consequence of medial artery infarction participated. A significant improvement of motor functions in the course of a 4-week treatment, as compared to the stable pre-treatment baseline, and compared with a control group have been found. The improvement lasted for at least 8 weeks after the end of the intervention. Additionally, the effects of action observation therapy on the reorganization of the motor system were investigated by functional magnetic resonance imaging (fMRI), using an independent sensorimotor task consisting of object manipulation. The direct comparison of neural activations between experimental and control groups after training with those elicited by the same task before training yielded a significant rise in activity in the bilateral ventral premotor cortex, bilateral superior temporal gyrus, the supplementary motor area (SMA) and the contralateral supramarginal gyrus. Our results provide pieces of evidence that action observation has a positive additional impact on recovery of motor functions after stroke by reactivation of motor areas, which contain the action observation/action execution matching system.

Optimization of Deep Drilling Performance - Development and Benchmark Testing of Advanced Diamond Product Drill Bits & HP/HT Fluids to Significantly Improve Rates of Penetration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alan Black; Arnis Judzis

2005-09-30

This document details the progress to date on the OPTIMIZATION OF DEEP DRILLING PERFORMANCE--DEVELOPMENT AND BENCHMARK TESTING OF ADVANCED DIAMOND PRODUCT DRILL BITS AND HP/HT FLUIDS TO SIGNIFICANTLY IMPROVE RATES OF PENETRATION contract for the year starting October 2004 through September 2005. The industry cost shared program aims to benchmark drilling rates of penetration in selected simulated deep formations and to significantly improve ROP through a team development of aggressive diamond product drill bit--fluid system technologies. Overall the objectives are as follows: Phase 1--Benchmark ''best in class'' diamond and other product drilling bits and fluids and develop concepts for amore » next level of deep drilling performance; Phase 2--Develop advanced smart bit-fluid prototypes and test at large scale; and Phase 3--Field trial smart bit--fluid concepts, modify as necessary and commercialize products. As of report date, TerraTek has concluded all Phase 1 testing and is planning Phase 2 development.« less

Data Assimilation to Extract Soil Moisture Information From SMAP Observations

NASA Technical Reports Server (NTRS)

Kolassa, J.; Reichle, R. H.; Liu, Q.; Alemohammad, S. H.; Gentine, P.

2017-01-01

Statistical techniques permit the retrieval of soil moisture estimates in a model climatology while retaining the spatial and temporal signatures of the satellite observations. As a consequence, they can be used to reduce the need for localized bias correction techniques typically implemented in data assimilation (DA) systems that tend to remove some of the independent information provided by satellite observations. Here, we use a statistical neural network (NN) algorithm to retrieve SMAP (Soil Moisture Active Passive) surface soil moisture estimates in the climatology of the NASA Catchment land surface model. Assimilating these estimates without additional bias correction is found to significantly reduce the model error and increase the temporal correlation against SMAP CalVal in situ observations over the contiguous United States. A comparison with assimilation experiments using traditional bias correction techniques shows that the NN approach better retains the independent information provided by the SMAP observations and thus leads to larger model skill improvements during the assimilation. A comparison with the SMAP Level 4 product shows that the NN approach is able to provide comparable skill improvements and thus represents a viable assimilation approach.

TS-Chemscore, a Target-Specific Scoring Function, Significantly Improves the Performance of Scoring in Virtual Screening.

PubMed

Wang, Wen-Jing; Huang, Qi; Zou, Jun; Li, Lin-Li; Yang, Sheng-Yong

2015-07-01

Most of the scoring functions currently used in structure-based drug design belong to 'universal' scoring functions, which often give a poor correlation between the calculated scores and experimental binding affinities. In this investigation, we proposed a simple strategy to construct target-specific scoring functions based on known 'universal' scoring functions. This strategy was applied to Chemscore, a widely used empirical scoring function, which led to a new scoring function, termed TS-Chemscore. TS-Chemscore was validated on 14 protein targets, which cover a wide range of biological target categories. The results showed that TS-Chemscore significantly improved the correlation between the calculated scores and experimental binding affinities compared with the original Chemscore. TS-Chemscore was then applied in virtual screening to retrieve novel JAK3 and YopH inhibitors. Top 30 compounds for each target were selected for experimental validation. Six active compounds for JAK3 and four for YopH were obtained. These compounds were out of the lists of top 30 compounds sorted by Chemscore. Collectively, TS-Chemscore established in this study showed a better performance in virtual screening than its counterpart Chemscore. © 2014 John Wiley & Sons A/S.

Climate Observations from Space

NASA Astrophysics Data System (ADS)

Briggs, Stephen

2016-07-01

The latest Global Climate Observing System (GCOS) Status Report on global climate observations, delivered to the UNFCCC COP21 in November 2016, showed how satellite data are critical for observations relating to climate. Of the 50 Essential Climate Variables (ECVs) identified by GCOS as necessary for understanding climate change, about half are derived only from satellite data while half of the remainder have a significant input from satellites. Hence data from Earth observing satellite systems are now a fundamental requirement for understanding the climate system and for managing the consequences of climate change. Following the Paris Agreement of COP21 this need is only greater. Not only will satellites have to continue to provide data for modelling and predicting climate change but also for a much wider range of actions relating to climate. These include better information on loss and damage, resilience, improved adaptation to change, and on mitigation including information on greenhouse gas emissions. In addition there is an emerging need for indicators of the risks associated with future climate change which need to be better quantified, allowing policy makers both to understand what decisions need to be taken, and to see the consequences of their actions. The presentation will set out some of the ways in which satellite data are important in all aspects of understanding, managing and predicting climate change and how they may be used to support future decisions by those responsible for policy related to managing climate change and its consequences.

Are parent-reported outcomes for self-directed or telephone-assisted behavioral family intervention enhanced if parents are observed?

PubMed

Morawska, Alina; Sanders, Matthew R

2007-05-01

The study examined the effects of conducting observations as part of a broader assessment of families participating in behavior family intervention (BFI). It was designed to investigate whether the observations improve intervention outcomes. Families were randomly assigned to different levels of BFI or a waitlist control condition and subsequently randomly assigned to either observation or no-observation conditions. This study demonstrated significant intervention and observation effects. Mothers in more intensive BFI reported more improvement in their child's behavior and their own parenting. Observed mothers reported lower intensity of child behavior problems and more effective parenting styles. There was also a trend for less anger among mothers who were observed and evidence of an observation-intervention interaction for parental anger, with observed mothers in more intensive intervention reporting less anger compared to those not observed. Implications for clinical and research intervention contexts are discussed.

Observation of STF 2686 from Haleakala

NASA Astrophysics Data System (ADS)

McGaughey, Stephen A.; Genet, Russell M.

2012-07-01

The visual double star STF 2686 was observed with a small telescope from the summit of Haleakala in Hawaii. Although our visually-estimated separation of 26.6 arc seconds was in close agreement with 19 past observations spread over 186 years, our position angle estimate of 277 degrees differed from the average of past observations by 1.5 degrees, a sizeable 2.4 sigma standard deviation difference. We concluded that in future observations from Haleakala with this telescope our precision could be improved by making multiple observations and by incorporating a Barlow in the optical path. Our position angle accuracy might be improved by rotating the astrometric eyepiece 180 degrees between each observation to avoid initial positioning bias.

Use of national surgical quality improvement program data as a catalyst for quality improvement.

PubMed

Rowell, Katherine S; Turrentine, Florence E; Hutter, Matthew M; Khuri, Shukri F; Henderson, William G

2007-06-01

Semiannually, the National Surgical Quality Improvement Program (NSQIP) provides its participating sites with observed-to-expected (O/E) ratios for 30-day postoperative mortality and morbidity. At each reporting period, there is typically a small group of hospitals with statistically significantly high O/E ratios, meaning that their patients have experienced more adverse events than would be expected on the basis of the population characteristics. An important issue is to determine which actions a surgical service should take in the presence of a high O/E ratio. This article reviews case studies of how some of the Department of Veterans Affairs and private-sector NSQIP participating sites used the clinically rich NSQIP database for local quality improvement efforts. Data on postoperative adverse events before and after these local quality improvement efforts are presented. After local quality improvement efforts, wound complication rates were reduced at the Salt Lake City Veterans Affairs medical center by 47%, surgical site infections in patients undergoing intraabdominal surgery were reduced at the University of Virginia by 36%, and urinary tract infections in vascular patients were reduced at the Massachusetts General Hospital by 74%. At some sites participating in the NSQIP, notably the Massachusetts General Hospital and the University of Virginia, the NSQIP has served as the basis for surgical service-wide outcomes research and quality improvement programs. The NSQIP not only provides participating sites with risk-adjusted surgical mortality and morbidity outcomes semiannually, but the clinically rich NSQIP database can also serve as a catalyst for local quality improvement programs to significantly reduce postoperative adverse event rates.

Analysis of variance to assess statistical significance of Laplacian estimation accuracy improvement due to novel variable inter-ring distances concentric ring electrodes.

PubMed

Makeyev, Oleksandr; Joe, Cody; Lee, Colin; Besio, Walter G

2017-07-01

Concentric ring electrodes have shown promise in non-invasive electrophysiological measurement demonstrating their superiority to conventional disc electrodes, in particular, in accuracy of Laplacian estimation. Recently, we have proposed novel variable inter-ring distances concentric ring electrodes. Analytic and finite element method modeling results for linearly increasing distances electrode configurations suggested they may decrease the truncation error resulting in more accurate Laplacian estimates compared to currently used constant inter-ring distances configurations. This study assesses statistical significance of Laplacian estimation accuracy improvement due to novel variable inter-ring distances concentric ring electrodes. Full factorial design of analysis of variance was used with one categorical and two numerical factors: the inter-ring distances, the electrode diameter, and the number of concentric rings in the electrode. The response variables were the Relative Error and the Maximum Error of Laplacian estimation computed using a finite element method model for each of the combinations of levels of three factors. Effects of the main factors and their interactions on Relative Error and Maximum Error were assessed and the obtained results suggest that all three factors have statistically significant effects in the model confirming the potential of using inter-ring distances as a means of improving accuracy of Laplacian estimation.

Very high energy gamma ray extension of GRO observations

NASA Technical Reports Server (NTRS)

Weekes, Trevor C.

1992-01-01

This has been an exiciting year for high energy gamma-ray astronomy, both from space and from ground-based observatories. It has been a particularly active period for the Whipple Observatory gamma-ray group. In phase 1 of the Compton Gamma Ray Observatory (GRO), there has not been too much opportunity for overlapping observations with the Energetic Gamma Ray Experiment Telescope (EGRET) and the other GRO telescopes; however, significant progress was made in the development of data analysis techniques and in improving the sensitivity of the technique which will have direct application in correlative observations in phase 2. Progress made during the period 1 Jul. 1991 - 31 Dec. 1991 is presented.

Relationships of multitasking, physicians' strain, and performance: an observational study in ward physicians.

PubMed

Weigl, Matthias; Müller, Andreas; Sevdalis, Nick; Angerer, Peter

2013-03-01

Simultaneous task performance ("multitasking") is common in hospital physicians' work and is implicated as a major determinant for enhanced strain and detrimental performance. The aim was to determine the impact of multitasking by hospital physicians on their self reported strain and performance. A prospective observational time-and-motion study in a Community Hospital was conducted. Twenty-seven hospital physicians (surgical and internal specialties) were observed in 40 full-shift observations. Observed physicians reported twice on their self-monitored strain and performance during the observation time. Associations of observed multitasking events and subsequent strain and performance appraisals were calculated. About 21% of the working time physicians were engaged in simultaneous activities. The average time spent in multitasking activities correlated significantly with subsequently reported strain (r = 0.27, P = 0.018). The number of instances of multitasking activities correlated with self-monitored performance to a marginally significant level (r = 0.19, P = 0.098). Physicians who engage in multitasking activities tend to self-report better performance but at the cost of enhanced psychophysical strain. Hence, physicians do not perceive their own multitasking activities as a source for deficient performance, for example, medical errors. Readjustment of workload, improved organization of work for hospital physicians, and training programs to improve physicians' skills in dealing with multiple clinical demands, prioritization, and efficient task allocation may be useful avenues to explore to reduce the potentially negative impact of simultaneous task performance in clinical settings.

Improved behavior after adenotonsillectomy in children with higher and lower IQ.

PubMed

Chung, Seockhoon; Hodges, Elise K; Ruzicka, Deborah L; Hoban, Timothy F; Garetz, Susan L; Guire, Kenneth E; Felt, Barbara T; Dillon, James E; Chervin, Ronald D; Giordani, Bruno

2016-01-01

To examine whether high intellectual ability, in comparison to average or lower performance, reflects the consequences of sleep-disordered breathing and limits behavioral benefit observed 6 months after adenotonsillectomy. Children aged 3-12 years (n=147) recruited from otolaryngology practices at two hospitals and assessed with Conners' Parent Rating Scales and an age range-appropriate intellectual measure, the Stanford-Binet Intelligence Scale at baseline and 6 months after clinically-indicated adenotonsillectomy. Subjects were classified as having high (IQ≥110), average (90≤IQ<110), or low (IQ<90) cognitive ability. After adenotonsillectomy, improvements in Conners' internalizing, externalizing, hyperactivity, and cognitive domains were observed across IQ groups (main effects for time, all p<0.01 or better), with no evidence for differential improvements among the groups (no significant time by IQ group interactions). The magnitude of behavioral improvement among children with high IQ resembled that observed among the other two groups. Changes in the Conners' domains were not significantly correlated with baseline IQ, age, socioeconomic status, body mass index z-score, or respiratory disturbance index. Behavioral function can improve after adenotonsillectomy even among children with relatively high intellectual ability at baseline. Diagnosis and treatment with expectation of neurobehavioral benefit should be considered among high-performing children as readily as it is more traditionally among their lower-performing peers. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Optimized distributed systems achieve significant performance improvement on sorted merging of massive VCF files.

PubMed

Sun, Xiaobo; Gao, Jingjing; Jin, Peng; Eng, Celeste; Burchard, Esteban G; Beaty, Terri H; Ruczinski, Ingo; Mathias, Rasika A; Barnes, Kathleen; Wang, Fusheng; Qin, Zhaohui S

2018-06-01

Sorted merging of genomic data is a common data operation necessary in many sequencing-based studies. It involves sorting and merging genomic data from different subjects by their genomic locations. In particular, merging a large number of variant call format (VCF) files is frequently required in large-scale whole-genome sequencing or whole-exome sequencing projects. Traditional single-machine based methods become increasingly inefficient when processing large numbers of files due to the excessive computation time and Input/Output bottleneck. Distributed systems and more recent cloud-based systems offer an attractive solution. However, carefully designed and optimized workflow patterns and execution plans (schemas) are required to take full advantage of the increased computing power while overcoming bottlenecks to achieve high performance. In this study, we custom-design optimized schemas for three Apache big data platforms, Hadoop (MapReduce), HBase, and Spark, to perform sorted merging of a large number of VCF files. These schemas all adopt the divide-and-conquer strategy to split the merging job into sequential phases/stages consisting of subtasks that are conquered in an ordered, parallel, and bottleneck-free way. In two illustrating examples, we test the performance of our schemas on merging multiple VCF files into either a single TPED or a single VCF file, which are benchmarked with the traditional single/parallel multiway-merge methods, message passing interface (MPI)-based high-performance computing (HPC) implementation, and the popular VCFTools. Our experiments suggest all three schemas either deliver a significant improvement in efficiency or render much better strong and weak scalabilities over traditional methods. Our findings provide generalized scalable schemas for performing sorted merging on genetics and genomics data using these Apache distributed systems.

Statistical Analyses of High-Resolution Aircraft and Satellite Observations of Sea Ice: Applications for Improving Model Simulations

NASA Astrophysics Data System (ADS)

Farrell, S. L.; Kurtz, N. T.; Richter-Menge, J.; Harbeck, J. P.; Onana, V.

2012-12-01

Satellite-derived estimates of ice thickness and observations of ice extent over the last decade point to a downward trend in the basin-scale ice volume of the Arctic Ocean. This loss has broad-ranging impacts on the regional climate and ecosystems, as well as implications for regional infrastructure, marine navigation, national security, and resource exploration. New observational datasets at small spatial and temporal scales are now required to improve our understanding of physical processes occurring within the ice pack and advance parameterizations in the next generation of numerical sea-ice models. High-resolution airborne and satellite observations of the sea ice are now available at meter-scale resolution or better that provide new details on the properties and morphology of the ice pack across basin scales. For example the NASA IceBridge airborne campaign routinely surveys the sea ice of the Arctic and Southern Oceans with an advanced sensor suite including laser and radar altimeters and digital cameras that together provide high-resolution measurements of sea ice freeboard, thickness, snow depth and lead distribution. Here we present statistical analyses of the ice pack primarily derived from the following IceBridge instruments: the Digital Mapping System (DMS), a nadir-looking, high-resolution digital camera; the Airborne Topographic Mapper, a scanning lidar; and the University of Kansas snow radar, a novel instrument designed to estimate snow depth on sea ice. Together these instruments provide data from which a wide range of sea ice properties may be derived. We provide statistics on lead distribution and spacing, lead width and area, floe size and distance between floes, as well as ridge height, frequency and distribution. The goals of this study are to (i) identify unique statistics that can be used to describe the characteristics of specific ice regions, for example first-year/multi-year ice, diffuse ice edge/consolidated ice pack, and convergent

Model training across multiple breeding cycles significantly improves genomic prediction accuracy in rye (Secale cereale L.).

PubMed

Auinger, Hans-Jürgen; Schönleben, Manfred; Lehermeier, Christina; Schmidt, Malthe; Korzun, Viktor; Geiger, Hartwig H; Piepho, Hans-Peter; Gordillo, Andres; Wilde, Peer; Bauer, Eva; Schön, Chris-Carolin

2016-11-01

Genomic prediction accuracy can be significantly increased by model calibration across multiple breeding cycles as long as selection cycles are connected by common ancestors. In hybrid rye breeding, application of genome-based prediction is expected to increase selection gain because of long selection cycles in population improvement and development of hybrid components. Essentially two prediction scenarios arise: (1) prediction of the genetic value of lines from the same breeding cycle in which model training is performed and (2) prediction of lines from subsequent cycles. It is the latter from which a reduction in cycle length and consequently the strongest impact on selection gain is expected. We empirically investigated genome-based prediction of grain yield, plant height and thousand kernel weight within and across four selection cycles of a hybrid rye breeding program. Prediction performance was assessed using genomic and pedigree-based best linear unbiased prediction (GBLUP and PBLUP). A total of 1040 S 2 lines were genotyped with 16 k SNPs and each year testcrosses of 260 S 2 lines were phenotyped in seven or eight locations. The performance gap between GBLUP and PBLUP increased significantly for all traits when model calibration was performed on aggregated data from several cycles. Prediction accuracies obtained from cross-validation were in the order of 0.70 for all traits when data from all cycles (N CS  = 832) were used for model training and exceeded within-cycle accuracies in all cases. As long as selection cycles are connected by a sufficient number of common ancestors and prediction accuracy has not reached a plateau when increasing sample size, aggregating data from several preceding cycles is recommended for predicting genetic values in subsequent cycles despite decreasing relatedness over time.

Scaling Observations of Surface Waves in the Beaufort Sea

DTIC Science & Technology

2016-04-14

the treatment of wind input can be improved in partial ice cover using the ice concentration, where wave energy is a function of open water distance...drifting buoys during the 2014 open water season, are interpreted using open water distances determined from satellite ice products and wind forcing time...series measured in situ with the buoys. A significant portion of the wave observations were found to be limited by open water distance (fetch) when

Do relationships exist between the scope and intensity of quality improvement activities and hospital operation performance? A 10-year observation in Taiwan.

PubMed

Chung, Kuo-Piao; Yu, Tsung-Hsien

2015-08-14

The relationship between the scope and intensity of quality improvement (QI) activities and hospital performance remains unclear. This study investigated the relationship between performance, external environment, and the scope and intensity of QI activities in hospitals. The study used a longitudinal observation. Data regarding the scope and intensity of QI activities were collected using a questionnaire survey among the administrative deputy superintendents / directors of quality management center in 139 hospitals. Hospital performance indicators were abstracted from the 2000-2009 national hospitals profiles. We adopted year 2000 as the baseline, and divided the study period into three 3-year periods. The Generalized Estimating Equations (GEE) model was used for the statistical analysis. Seventy-two hospitals responded to the survey, giving a response rate of 52%. The results showed a significant increase in the scope and intensity of QI activities between 2000 and 2009. The results also showed that the scope and intensity of a hospital's QI activities were associated with the scope and intensity of its competitors' QI activities in the previous period and its own prior performance. The scope of QI activities in the previous period was not significantly related to the selected hospital performance measures. However, the intensity of QI activities in the previous period showed a significant and positive relationship with the number of inpatients and the turnover of beds. The study demonstrates that the intensity of QI activities is associated with the external environment and the hospital's own performance in the previous period. Furthermore, some performance measures are associated with the intensity of the QI activities in the previous period.

Accelerating assimilation development for new observing systems using EFSO

NASA Astrophysics Data System (ADS)

Lien, Guo-Yuan; Hotta, Daisuke; Kalnay, Eugenia; Miyoshi, Takemasa; Chen, Tse-Chun

2018-03-01

To successfully assimilate data from a new observing system, it is necessary to develop appropriate data selection strategies, assimilating only the generally useful data. This development work is usually done by trial and error using observing system experiments (OSEs), which are very time and resource consuming. This study proposes a new, efficient methodology to accelerate the development using ensemble forecast sensitivity to observations (EFSO). First, non-cycled assimilation of the new observation data is conducted to compute EFSO diagnostics for each observation within a large sample. Second, the average EFSO conditionally sampled in terms of various factors is computed. Third, potential data selection criteria are designed based on the non-cycled EFSO statistics, and tested in cycled OSEs to verify the actual assimilation impact. The usefulness of this method is demonstrated with the assimilation of satellite precipitation data. It is shown that the EFSO-based method can efficiently suggest data selection criteria that significantly improve the assimilation results.

Rational reduction of periodic propagators for off-period observations.

PubMed

Blanton, Wyndham B; Logan, John W; Pines, Alexander

2004-02-01

Many common solid-state nuclear magnetic resonance problems take advantage of the periodicity of the underlying Hamiltonian to simplify the computation of an observation. Most of the time-domain methods used, however, require the time step between observations to be some integer or reciprocal-integer multiple of the period, thereby restricting the observation bandwidth. Calculations of off-period observations are usually reduced to brute force direct methods resulting in many demanding matrix multiplications. For large spin systems, the matrix multiplication becomes the limiting step. A simple method that can dramatically reduce the number of matrix multiplications required to calculate the time evolution when the observation time step is some rational fraction of the period of the Hamiltonian is presented. The algorithm implements two different optimization routines. One uses pattern matching and additional memory storage, while the other recursively generates the propagators via time shifting. The net result is a significant speed improvement for some types of time-domain calculations.

Controllers, observers, and applications thereof

NASA Technical Reports Server (NTRS)

Gao, Zhiqiang (Inventor); Zhou, Wankun (Inventor); Miklosovic, Robert (Inventor); Radke, Aaron (Inventor); Zheng, Qing (Inventor)

2011-01-01

Controller scaling and parameterization are described. Techniques that can be improved by employing the scaling and parameterization include, but are not limited to, controller design, tuning and optimization. The scaling and parameterization methods described here apply to transfer function based controllers, including PID controllers. The parameterization methods also apply to state feedback and state observer based controllers, as well as linear active disturbance rejection (ADRC) controllers. Parameterization simplifies the use of ADRC. A discrete extended state observer (DESO) and a generalized extended state observer (GESO) are described. They improve the performance of the ESO and therefore ADRC. A tracking control algorithm is also described that improves the performance of the ADRC controller. A general algorithm is described for applying ADRC to multi-input multi-output systems. Several specific applications of the control systems and processes are disclosed.

Improving Estimates and Forecasts of Lake Carbon Pools and Fluxes Using Data Assimilation

NASA Astrophysics Data System (ADS)

Zwart, J. A.; Hararuk, O.; Prairie, Y.; Solomon, C.; Jones, S.

2017-12-01

Lakes are biogeochemical hotspots on the landscape, contributing significantly to the global carbon cycle despite their small areal coverage. Observations and models of lake carbon pools and fluxes are rarely explicitly combined through data assimilation despite significant use of this technique in other fields with great success. Data assimilation adds value to both observations and models by constraining models with observations of the system and by leveraging knowledge of the system formalized by the model to objectively fill information gaps. In this analysis, we highlight the utility of data assimilation in lake carbon cycling research by using the Ensemble Kalman Filter to combine simple lake carbon models with observations of lake carbon pools. We demonstrate the use of data assimilation to improve a model's representation of lake carbon dynamics, to reduce uncertainty in estimates of lake carbon pools and fluxes, and to improve the accuracy of carbon pool size estimates relative to estimates derived from observations alone. Data assimilation techniques should be embraced as valuable tools for lake biogeochemists interested in learning about ecosystem dynamics and forecasting ecosystem states and processes.

Interventions to improve adherence to tuberculosis treatment: systematic review and meta-analysis.

PubMed

Müller, A M; Osório, C S; Silva, D R; Sbruzzi, G; de Tarso, P; Dalcin, Roth

2018-07-01

One of the most serious problems in tuberculosis (TB) control is non-adherence to treatment. Several strategies have been developed to improve adherence and increase the cure rate. To systematically review interventions to improve adherence to anti-tuberculosis treatment. We performed a systematic review and meta-analysis of 22 randomised clinical trials (RCTs) to ascertain whether providing directly observed treatment, short-course (DOTS), financial incentives, food incentives and/or patient education/counselling improved adherence to anti-tuberculosis treatment. The primary outcome was cure rate; secondary outcomes were default and mortality rates. Sources used were Medline (accessed via PubMed), Cochrane Central, LILACS (Literatura Latino Americana em Ciências da Saúde, Latin American and Caribbean Health Sciences Literature) and Embase from inception to October 2015. A significant increase in cure rates, by 18% with DOTS and by 16% with patient education and counselling, was observed. In addition, the default rate decreased by 49% with DOTS, by 26% with financial incentives and by 13% with patient education and counselling. There was no statistically significant reduction in mortality rates with these interventions. Use of DOTS and patient education/counselling significantly improved cure rates; DOTS, patient education/counselling and financial incentives led to a reduction in the default rate.

Improved word recognition for observers with age-related maculopathies using compensation filters

NASA Technical Reports Server (NTRS)

Lawton, Teri B.

1988-01-01

A method for improving word recognition for people with age-related maculopathies, which cause a loss of central vision, is discussed. It is found that the use of individualized compensation filters based on an person's normalized contrast sensitivity function can improve word recognition for people with age-related maculopathies. It is shown that 27-70 pct more magnification is needed for unfiltered words compared to filtered words. The improvement in word recognition is positively correlated with the severity of vision loss.

Navy Financial Management: Improved Management of Operating Materials and Supplies Could Yield Significant Savings

DTIC Science & Technology

1996-08-16

This report provides the results of our detailed assessment of the Navy’s financial reporting on and management of operating materials and supplies...also contains recommendations that are directed at improving financial reporting and inventory management.

Improvement of the GPS/A system for extensive observation along subduction zones around Japan

NASA Astrophysics Data System (ADS)

Fujimoto, H.; Kido, M.; Tadokoro, K.; Sato, M.; Ishikawa, T.; Asada, A.; Mochizuki, M.

2011-12-01

Combined high-resolution gravity field models serve as a mandatory basis to describe static and dynamic processes in system Earth. Ocean dynamics can be modeled referring to a high-accurate geoid as reference surface, solid earth processes are initiated by the gravity field. Also geodetic disciplines such as height system determination depend on high-precise gravity field information. To fulfill the various requirements concerning resolution and accuracy, any kind of gravity field information, that means satellite as well as terrestrial and altimetric gravity field observations have to be included in one combination process. A key role is here reserved for GOCE observations, which contribute with its optimal signal content in the long to medium wavelength part and enable a more accurate gravity field determination than ever before especially in areas, where no high-accurate terrestrial gravity field observations are available, such as South America, Asia or Africa. For our contribution we prepare a combined high-resolution gravity field model up to d/o 720 based on full normal equation including recent GOCE, GRACE and terrestrial / altimetric data. For all data sets, normal equations are set up separately, relative weighted to each other in the combination step and solved. This procedure is computationally challenging and can only be performed using super computers. We put special emphasis on the combination process, for which we modified especially our procedure to include GOCE data optimally in the combination. Furthermore we modified our terrestrial/altimetric data sets, what should result in an improved outcome. With our model, in which we included the newest GOCE TIM4 gradiometry results, we can show how GOCE contributes to a combined gravity field solution especially in areas of poor terrestrial data coverage. The model is validated by independent GPS leveling data in selected regions as well as computation of the mean dynamic topography over the oceans

Improving the ideal and human observer consistency: a demonstration of principles

NASA Astrophysics Data System (ADS)

He, Xin

2017-03-01

In addition to being rigorous and realistic, the usefulness of the ideal observer computational tools may also depend on whether they serve the empirical purpose for which they are created, e.g. to identify desirable imaging systems to be used by human observers. In SPIE 10136-35, I have shown that the ideal and the human observers do not necessarily prefer the same system as the optimal or better one due to their different objectives in both hardware and software optimization. In this work, I attempt to identify a necessary but insufficient condition under which the human and the ideal observer may rank systems consistently. If corroborated, such a condition allows a numerical test on the ideal/human consistency without routine human observer studies. I reproduced data from Abbey et al. JOSA 2001 to verify the proposed condition (i.e., not a rigorous falsification study due to the lack of specificity in the proposed conjecture. A roadmap for more falsifiable conditions is proposed). Via this work, I would like to emphasize the reality of practical decision making in addition to the realism in mathematical modeling. (Disclaimer: the views expressed in this work do not necessarily represent those of the FDA.)

Skylab-4 visual observations project: Geological features of southwestern North America

NASA Technical Reports Server (NTRS)

Silver, L. T.

1975-01-01

Visual observations conducted by Skylab-4 crewmen on seven designated geological target areas and other targets of opportunity in parts of southwestern United States and northwestern Mexico were described. The experiments were designed to learn how effectively geologic features could be observed from orbit and what research information could be obtained from the observations when supported by ground studies. For the limited preparation they received, the crewmen demonstrated exceptional observational ability and produced outstanding photographic studies. They also formulated cogent opinions on how to improve future observational and photo-documentation techniques. From the photographs and other observations, it was possible to obtain significant research contributions to on-going field investigations. These contributions were integrated into other aspects of the ground investigations to the following topics: major faults, regional stratigraphy, occurrence of Precambrian crystalline rocks, mapping of Mesozoic volcanic rocks, regional geology.

Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: a randomized study.

PubMed

Poynard, Thierry; Bruix, Jordi; Schiff, Eugene R; Diago, Moises; Berg, Thomas; Moreno-Otero, Ricardo; Lyra, Andre C; Carrilho, Flair; Griffel, Louis H; Boparai, Navdeep; Jiang, Ruiyun; Burroughs, Margaret; Brass, Clifford A; Albrecht, Janice K

2013-03-01

Therapeutic options for patients failing hepatitis C retreatment are limited. EPIC(3) included a prospective trial assessing long-term peginterferon alfa-2b (PegIFNα-2b) maintenance therapy in patients with METAVIR fibrosis scores (MFS) of F2 or F3 who previously failed hepatitis C retreatment. Patients with F2/F3 MFS who failed retreatment were randomized to PegIFNα-2b (0.5 μg/kg/week, n=270) or observation (n=270) for 36 months. Blinded liver biopsies obtained before retreatment and after maintenance therapy were evaluated using MFS and activity scores, and confirmatory testing was performed using FibroTest and ActiTest. In total, 348 patients had paired biopsies: 192 patients had missing post-treatment biopsies and were considered as having no change in fibrosis/activity scores. In total, 16% of patients receiving PegIFNα-2b and 11% of observation patients had improvement in MFS (p=0.32). More PegIFNα-2b than observation patients had improvement in activity score (20% vs. 9%; p <0.001). Among patients treated for >2.5 years, improvement in MFS or activity score was more common with PegIFNα-2b than observation (21% vs. 14%, p=0.08 and 26% vs. 10%, p <0.001). FibroTest and ActiTest evaluations indicated significant benefit associated with PegIFNα-2b in terms of reduced fibrosis progression and improved activity score. The safety profile of PegIFNα-2b was similar to previous studies. PegIFNα-2b did not significantly improve MFS estimated by biopsy compared with observation; however, activity scores were significantly improved and MFS trended toward increased improvement with treatment durations >2.5 years. Both FibroTest and ActiTest were significantly improved during maintenance therapy. Copyright © 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

Does cognition improve following LVAD implantation?

PubMed

Pavol, Marykay A; Willey, Joshua Z; Wei, Ying; Yuzefpolskaya, Melana; Marshall, Randolph S; Marascalco, Philip J; Harwood, Jason; Lazar, Ronald M

2018-05-23

Studies of cognition after LVAD surgery have produced mixed results. To explore whether cognition would improve, decline, or remain stable after LVAD surgery, we examined cognition before and 1- and 3-months after LVAD surgery. Patients with post-surgical stroke were excluded. 28 subjects (mean age = 54.31 ± 12 years) comprised an observational case series from the DuraHeart LVAS device® trial. Cognitive testing was performed at baseline, 1-month, and 3-month post-surgery, and included tests of attention, memory, language, visualmotor speed (TMT) and visualconstruction. No difference in cognition was found between baseline and 1-month exams (means z score improvement = 0.06, p = 0.43) but cognition improved significantly between baseline and 3-month exams (mean z score improvement = 0.34, p < 0.00001). Examination of individual test scores found, after correction for multiple comparisons, only the TMT variable was significantly different at the 3-month exam. We found significantly improved cognition 3 months after LVAD surgery in a subset of patients without post-surgical stroke. The reasons for the lack of cognitive improvement at the 1-month post-surgical assessment may include ongoing medical and physiological disruptions in the immediate post-operative period. Further research into the sources of delayed improvement is warranted. Cognitive assessments performed immediately after surgery should be interpreted with caution because the results may not reflect longer term cognitive outcomes. LVAD patients may require additional support to successfully manage their health in the weeks immediately following surgery but assistance needs may decrease over time.

Sequestration of PDC-109 protein improves freezability of crossbred bull spermatozoa.

PubMed

Srivastava, N; Srivastava, S K; Ghosh, S K; Singh, L P; Prasad, J K; Kumar, Amit; Perumal, P; Jerome, A; Thamizharasan, A

2012-03-01

A study was carried out to assess the effect of sequestration of PDC-109 protein, a majority constituent of heparin binding proteins (HBP) of seminal plasma, on freezability and in vitro fertilizing ability of crossbred bull spermatozoa after cryopreservation. The study consisted of isolation and characterization of PDC-109 protein to raise anti-sera against it in rabbits. Following which, raised antibodies against PDC-109 protein was quantitated and coated in tubes used for collection of ejaculates. Semen ejaculates thus collected were cryopreserved using EYTG extender. Physico-morphological characteristics, viz. motility, viability, acrosomal integrity and HOS response as an indicator of freezability of cryopreserved spermatozoa were determined at pre freeze as well as post thaw stage. At pre freeze stage, a significant (p<0.05) improvement in viability (83.83 ± 2.18 vs 75.17 ± 2.42) and acrosome integrity (81.33 ± 2.38 vs 72.83 ± 2.39) in antibodies treated group than control was observed. Similarly, increase in HOS responsive spermatozoa was highly significant (p<0.01) than control (78.83 ± 1.69 vs 67.5 ± 1.75). At post thaw stage, significant (p<0.05) improvement in viability (69.50 ± 2.16 vs 60.33 ± 2.19) and HOS responsive spermatozoa (68.67 ± 1.62 vs 58.50 ± 1.32) and highly significant (p<0.01) increase in individual motility (56.17 ± 1.83 vs 47.00 ± 1.86) and acrosome integrity (75.17 ± 2.38 vs 61.83 ± 2.1) was observed in antibodies treated group when compared to control was observed. The results from the study revealed that sequestration of PDC-109 protein from semen samples leads to significant improvement in pre-freeze and post-thaw values of above parameters in cryopreserved spermatozoa. It is thus concluded that sequestration of PDC-109 protein from ejaculates improves freezability of crossbred bull spermatozoa. Copyright © 2012 Elsevier B.V. All rights reserved.

Microcirculatory Improvement Induced by Laparoscopic Sleeve Gastrectomy Is Related to Insulin Sensitivity Retrieval.

PubMed

Ministrini, Stefano; Fattori, Chiara; Ricci, Maria Anastasia; Bianconi, Vanessa; Paltriccia, Rita; Boni, Marcello; Paganelli, Maria Teresa; Vaudo, Gaetano; Lupattelli, Graziana; Pasqualini, Leonella

2018-05-12

Microvascular dysfunction is a potential factor explaining the association of obesity, insulin resistance, and vascular damage in morbidly obese subjects. The purpose of the study was to evaluate possible determinants of microcirculatory improvement 1 year after laparoscopic sleeve gastrectomy (LSG) intervention. Thirty-seven morbidly obese subjects eligible for bariatric surgery were included in the study. Post-occlusive reactive hyperemia (PORH) of the forearm skin was measured as area of hyperemia (AH) by laser-Doppler flowmetry before LSG and after a 1-year follow-up. After intervention, we observed a significant reduction in BMI, HOMA index, HbA1c, and a significant increase of AH in all patients after surgery; this variation was significant only in those patients having insulin resistance or prediabetes/diabetes. Although significant correlation between the increase of AH and the reduction of both BMI, HOMA index, and HbA1c was observed, BMI was the only independent predictor of AH variation after LSG at the linear regression analysis. Our study shows that LSG intervention is correlated with a significant improvement in the microvascular function of morbidly obese subjects; this improvement seems to be related to the baseline degree of insulin-resistance and to the retrieval of insulin-sensitivity post-intervention.

Ranges of motion after reverse shoulder arthroplasty improve significantly the first year after surgery in patients with rheumatoid arthritis.

PubMed

Tiusanen, Hannu; Sarantsin, Pjotor; Stenholm, Miika; Mattie, Ryan; Saltychev, Mikhail

2016-07-01

To evaluate the trajectory of the change in range of motion after reverse shoulder joint replacement during 3-year follow-up among patients with rheumatoid arthritis. Retrospective cohort longitudinal study of 76 shoulder replacements performed in a university clinic. The range of shoulder motion was assessed by a physiotherapist using a manual goniometer with 5-degree precision before the surgery and 1, 3, 6, 12, and 36 months postoperatively. The shapes of the regression curves suggest that the improvement or decline observed in joint motion was happening mostly during the first year after surgery. After 1 year, the trajectories become flat and they remained unchanged until the end of follow-up. After shoulder joint replacement, the range of shoulder motion showed substantial changes during the first year only. This should be taken into account when scheduling control visits, planning rehabilitation, and predicting the use of community services after the surgery.

MO-FG-204-03: Using Edge-Preserving Algorithm for Significantly Improved Image-Domain Material Decomposition in Dual Energy CT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, W; Niu, T; Xing, L

2015-06-15

Purpose: To significantly improve dual energy CT (DECT) imaging by establishing a new theoretical framework of image-domain material decomposition with incorporation of edge-preserving techniques. Methods: The proposed algorithm, HYPR-NLM, combines the edge-preserving non-local mean filter (NLM) with the HYPR-LR (Local HighlY constrained backPRojection Reconstruction) framework. Image denoising using HYPR-LR framework depends on the noise level of the composite image which is the average of the different energy images. For DECT, the composite image is the average of high- and low-energy images. To further reduce noise, one may want to increase the window size of the filter of the HYPR-LR, leadingmore » resolution degradation. By incorporating the NLM filtering and the HYPR-LR framework, HYPR-NLM reduces the boost material decomposition noise using energy information redundancies as well as the non-local mean. We demonstrate the noise reduction and resolution preservation of the algorithm with both iodine concentration numerical phantom and clinical patient data by comparing the HYPR-NLM algorithm to the direct matrix inversion, HYPR-LR and iterative image-domain material decomposition (Iter-DECT). Results: The results show iterative material decomposition method reduces noise to the lowest level and provides improved DECT images. HYPR-NLM significantly reduces noise while preserving the accuracy of quantitative measurement and resolution. For the iodine concentration numerical phantom, the averaged noise levels are about 2.0, 0.7, 0.2 and 0.4 for direct inversion, HYPR-LR, Iter- DECT and HYPR-NLM, respectively. For the patient data, the noise levels of the water images are about 0.36, 0.16, 0.12 and 0.13 for direct inversion, HYPR-LR, Iter-DECT and HYPR-NLM, respectively. Difference images of both HYPR-LR and Iter-DECT show edge effect, while no significant edge effect is shown for HYPR-NLM, suggesting spatial resolution is well preserved for HYPR-NLM. Conclusion

Quality improvement in coronary care: analysis of sustainability and impact on adjacent clinical measures after a Swedish controlled, multicenter quality improvement collaborative.

PubMed

Carlhed, Rickard; Bellman, Christina; Bojestig, Mats; Bojö, Leif; Peterson, Anette; Lindahl, Bertil

2012-08-01

Quality Improvement in Coronary Care, a Swedish multicenter, controlled quality-improvement (QI) collaborative, has shown significant improvements in adherence to national guidelines for acute myocardial infarction, as well as improved clinical outcome. The objectives of this report were to describe the sustainability of the improvements after withdrawal of study support and a consolidation period of 3 months and to report whether improvements were disseminated to treatments and diagnostic procedures other than those primarily targeted. Multidisciplinary teams from 19 Swedish hospitals were educated in basic QI methodologies. Another 19 matched hospitals were included as blinded controls. All evaluations were made on the hospital level, and data were obtained from a national quality registry, Swedish Register of Information and Knowledge About Swedish Heart Intensive Care Admissions (RIKS-HIA). Sustainability indicators consisted of use of angiotensin-converting enzyme inhibitors, lipid-lowering therapy, clopidogrel, low-molecular weight heparin, and coronary angiography. Dissemination indicators were use of echocardiography, stress tests, and reperfusion therapy; time delays; and length of stay. At the reevaluation period of 6 months, the improvements at the QI intervention hospitals were sustained in all indicators but 1 (angiotensin-converting enzyme inhibitor). Between the 2 measurements, the control group improved significantly in all but 1 indicator (angiotensin-converting enzyme inhibitor). However, at the second measurement, the absolute adherence rates of the intervention hospitals were still numerically higher in all 5 indicators, and significantly so in 1 (clopidogrel). No significant changes were observed for the dissemination indicators. The combination of a systematic QI collaborative with a national, interactive quality registry might lead to substantial and sustained improvements in the quality of acute myocardial infarction care. However, to

Predicting significant torso trauma.

PubMed

Nirula, Ram; Talmor, Daniel; Brasel, Karen

2005-07-01

Identification of motor vehicle crash (MVC) characteristics associated with thoracoabdominal injury would advance the development of automatic crash notification systems (ACNS) by improving triage and response times. Our objective was to determine the relationships between MVC characteristics and thoracoabdominal trauma to develop a torso injury probability model. Drivers involved in crashes from 1993 to 2001 within the National Automotive Sampling System were reviewed. Relationships between torso injury and MVC characteristics were assessed using multivariate logistic regression. Receiver operating characteristic curves were used to compare the model to current ACNS models. There were a total of 56,466 drivers. Age, ejection, braking, avoidance, velocity, restraints, passenger-side impact, rollover, and vehicle weight and type were associated with injury (p < 0.05). The area under the receiver operating characteristic curve (83.9) was significantly greater than current ACNS models. We have developed a thoracoabdominal injury probability model that may improve patient triage when used with ACNS.

Novel ventilation design of combining spacer and mesh structure in sports T-shirt significantly improves thermal comfort.

PubMed

Sun, Chao; Au, Joe Sau-chuen; Fan, Jintu; Zheng, Rong

2015-05-01

This paper reports on novel ventilation design in sports T-shirt, which combines spacer and mesh structure, and experimental evidence on the advantages of design in improving thermal comfort. Evaporative resistance (Re) and thermal insulation (Rc) of T-shirts were measured using a sweating thermal manikin under three different air velocities. Moisture permeability index (i(m)) was calculated to compare the different designed T-shirts. The T-shirts of new and conventional designs were also compared by wearer trials, which were comprised of 30 min treadmill running followed by 10 min rest. Skin temperature, skin relative humidity, heart rate, oxygen inhalation and energy expenditure were monitored, and subjective sensations were asked. Results demonstrated that novel T-shirt has 11.1% significant lower im than control sample under windy condition. The novel T-shirt contributes to reduce the variation of skin temperature and relative humidity up to 37% and 32%, as well as decrease 3.3% energy consumption during exercise. Copyright © 2014 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Significant improvement of thermal stability of glucose 1-dehydrogenase by introducing disulfide bonds at the tetramer interface.

PubMed

Ding, Haitao; Gao, Fen; Liu, Danfeng; Li, Zeli; Xu, Xiaohong; Wu, Min; Zhao, Yuhua

2013-12-10

Rational design was applied to glucose 1-dehydrogenase (LsGDH) from Lysinibacillus sphaericus G10 to improve its thermal stability by introduction of disulfide bridges between subunits. One out of the eleven mutants, designated as DS255, displayed significantly enhanced thermal stability with considerable soluble expression and high specific activity. It was extremely stable at pH ranging from 4.5 to 10.5, as it retained nearly 100% activity after incubating at different buffers for 1h. Mutant DS255 also exhibited high thermostability, having a half-life of 9900min at 50°C, which was 1868-fold as that of its wild type. Moreover, both of the increased free energy of denaturation and decreased entropy of denaturation of DS255 suggested that the enzyme structure was stabilized by the engineered disulfide bonds. On account of its robust stability, mutant DS255 would be a competitive candidate in practical applications of chiral chemicals synthesis, biofuel cells and glucose biosensors. Copyright © 2013 Elsevier Inc. All rights reserved.

Significantly improved photovoltaic performance in polymer bulk heterojunction solar cells with graphene oxide /PEDOT:PSS double decked hole transport layer

PubMed Central

Rafique, Saqib; Abdullah, Shahino Mah; Shahid, Muhammad Mehmood; Ansari, Mohammad Omaish; Sulaiman, Khaulah

2017-01-01

This work demonstrates the high performance graphene oxide (GO)/PEDOT:PSS doubled decked hole transport layer (HTL) in the PCDTBT:PC71BM based bulk heterojunction organic photovoltaic device. The devices were tested on merits of their power conversion efficiency (PCE), reproducibility, stability and further compared with the devices with individual GO or PEDOT:PSS HTLs. Solar cells employing GO/PEDOT:PSS HTL yielded a PCE of 4.28% as compared to either of individual GO or PEDOT:PSS HTLs where they demonstrated PCEs of 2.77 and 3.57%, respectively. In case of single GO HTL, an inhomogeneous coating of ITO caused the poor performance whereas PEDOT:PSS is known to be hygroscopic and acidic which upon direct contact with ITO reduced the device performance. The improvement in the photovoltaic performance is mainly ascribed to the increased charge carriers mobility, short circuit current, open circuit voltage, fill factor, and decreased series resistance. The well matched work function of GO and PEDOT:PSS is likely to facilitate the charge transportation and an overall reduction in the series resistance. Moreover, GO could effectively block the electrons due to its large band-gap of ~3.6 eV, leading to an increased shunt resistance. In addition, we also observed the improvement in the reproducibility and stability. PMID:28084304

[Observation on imprints of the tongue caused by recurrent oropharyngeal ulcers and its clinical significance].

PubMed

Qiu, Z X; Feng, Z Y; Huang, H A

1989-03-01

In this article 36 cases of recurrent oropharyngeal ulcers were differentiated according to the local condition of the oropharyngeal ulcerations, tongue pictures, pulse feeling and other signs and symptoms. The authors considered this disease as the deficiency syndrome accompanied with the excess syndrome. The three steps for treatment were: Treating the Biao (secondary) aspect for emergency, then simultaneous treatment of Biao and Ben (primary), and lastly reinforcing the body resistance. The course of treatment lasted three months. The whole effective rate was 86.21%. The patients were divided into A and B groups according to the situation, the area, the amount and the deep degree of oropharyngeal ulcerations. The result of observation on exfoliated cells by imprints of tongue of two groups, The positive rates of six indices in the imprints of tongue of B group were higher than those of A group obviously (P less than 0.05-0.005). It conformed to the serious condition of the patients of B group, in which the number and area and deep degree of ulcers were more and larger and deeper, and their distributions were often involved in pharynx and larynx. Therefore the observation of the imprints of tongue may pre-indicate the conditions of the illness which will get better or worse. A comparison of before- and after-treatment showed that positive rates of all indices were reduced markedly (P less than 0.05-0.005). It proved that the observation of tongue picture by the imprint was more sensitive and exact than by the naked eye. It was proved beneficial to evaluating the therapeutic effect and prognosis.

The efficacy of direct anti-HCV drugs improves early post-liver transplant survival and induces significant changes in waiting list composition.

PubMed

Crespo, Gonzalo; Trota, Núria; Londoño, Maria-Carlota; Mauro, Ezequiel; Baliellas, Carme; Castells, Lluís; Castellote, Jose; Tort, Jaume; Forns, Xavier; Navasa, Miquel

2018-07-01

The efficacy of direct-acting antivirals (DAAs) has dramatically changed the prognosis of patients with chronic hepatitis C. We aimed to evaluate the impact of DAA therapy on the composition of the liver transplant (LT) waiting list and the early post-transplant survival. We evaluated all patients admitted to the waiting list for a primary LT between 1st January 2008 and 31st of December 2016 in Catalonia, Spain. Time span was divided into two periods according to the availability of different antiviral therapies: 2008-2013 (interferon-based therapies) and 2014-2016 (DAA). Changes in the indications of LT and the aetiology of liver disease, as well as post-LT patient survival, were evaluated according to the year of inclusion and transplantation, respectively. We included 1,483 patients. Admissions in the waiting list for hepatitis C virus (HCV)-related liver disease decreased significantly, from 47% in 2008-2013 to 35% in 2014-2016 (p <0.001), particularly because of a reduction in patients with decompensated cirrhosis. In contrast, NASH-related inclusions increased from 4% to 7% (p = 0.003). Three-year post-LT patient survival increased significantly in the second period in the whole cohort (82% vs. 91%, p = 0.002), because of better survival in anti-HCV positive patients (76% vs. 91%, p = 0.001), but not in anti-HCV negative patients (88% vs. 91% p = 0.359). Anti-HCV positive serology, the time period of 2008-2013 and higher donor age were independently associated with post-LT mortality in the whole cohort; while time period and donor age were independently associated with post-LT mortality in anti-HCV positive recipients. The high efficacy of DAAs is associated with significant changes in the composition of the LT waiting list and, more importantly, results in improved post-transplant survival. The efficacy of the new direct-acting antivirals is associated with a significant improvement in survival of patients undergoing liver transplantation

Optimized distributed systems achieve significant performance improvement on sorted merging of massive VCF files

PubMed Central

Gao, Jingjing; Jin, Peng; Eng, Celeste; Burchard, Esteban G; Beaty, Terri H; Ruczinski, Ingo; Mathias, Rasika A; Barnes, Kathleen; Wang, Fusheng

2018-01-01

Abstract Background Sorted merging of genomic data is a common data operation necessary in many sequencing-based studies. It involves sorting and merging genomic data from different subjects by their genomic locations. In particular, merging a large number of variant call format (VCF) files is frequently required in large-scale whole-genome sequencing or whole-exome sequencing projects. Traditional single-machine based methods become increasingly inefficient when processing large numbers of files due to the excessive computation time and Input/Output bottleneck. Distributed systems and more recent cloud-based systems offer an attractive solution. However, carefully designed and optimized workflow patterns and execution plans (schemas) are required to take full advantage of the increased computing power while overcoming bottlenecks to achieve high performance. Findings In this study, we custom-design optimized schemas for three Apache big data platforms, Hadoop (MapReduce), HBase, and Spark, to perform sorted merging of a large number of VCF files. These schemas all adopt the divide-and-conquer strategy to split the merging job into sequential phases/stages consisting of subtasks that are conquered in an ordered, parallel, and bottleneck-free way. In two illustrating examples, we test the performance of our schemas on merging multiple VCF files into either a single TPED or a single VCF file, which are benchmarked with the traditional single/parallel multiway-merge methods, message passing interface (MPI)–based high-performance computing (HPC) implementation, and the popular VCFTools. Conclusions Our experiments suggest all three schemas either deliver a significant improvement in efficiency or render much better strong and weak scalabilities over traditional methods. Our findings provide generalized scalable schemas for performing sorted merging on genetics and genomics data using these Apache distributed systems. PMID:29762754

A Matter of Timing: Identifying Significant Multi-Dose Radiotherapy Improvements by Numerical Simulation and Genetic Algorithm Search

PubMed Central

Angus, Simon D.; Piotrowska, Monika Joanna

2014-01-01

-effecitive means of significantly improving clinical efficacy. PMID:25460164

A matter of timing: identifying significant multi-dose radiotherapy improvements by numerical simulation and genetic algorithm search.