Observational Consequences of an Interacting Multiverse
NASA Astrophysics Data System (ADS)
Robles-Pérez, Salvador
2017-05-01
The observability of the multiverse is at the very root of its physical significance as a scientific proposal. In this conference we present, within the third quantization formalism, an interacting scheme between the wave functions of different universes and analyze the effects of some particular values of the coupling function. One of the main consequences of the interaction between universes can be the appearance of a pre-inflationary stage in the evolution of the universes that might leave observable consequences in the properties of the CMB.
Significant drug-nutrient interactions.
Kirk, J K
1995-04-01
Many nutrients substantially interfere with pharmacotherapeutic goals. The presence of certain nutrients in the gastrointestinal tract affects the bioavailability and disposition of many oral medications. Drug-nutrient interactions can also have positive effects that result in increased drug absorption or reduced gastrointestinal irritation. Knowing the significant drug-nutrient interactions can help the clinician identify the nutrients to avoid with certain medications, as well as the therapeutic agents that should be administered with food. This information can be used to educate patients and optimize pharmacotherapy.
Social interaction enhances motor resonance for observed human actions.
Hogeveen, Jeremy; Obhi, Sukhvinder S
2012-04-25
Understanding the neural basis of social behavior has become an important goal for cognitive neuroscience and a key aim is to link neural processes observed in the laboratory to more naturalistic social behaviors in real-world contexts. Although it is accepted that mirror mechanisms contribute to the occurrence of motor resonance (MR) and are common to action execution, observation, and imitation, questions remain about mirror (and MR) involvement in real social behavior and in processing nonhuman actions. To determine whether social interaction primes the MR system, groups of participants engaged or did not engage in a social interaction before observing human or robotic actions. During observation, MR was assessed via motor-evoked potentials elicited with transcranial magnetic stimulation. Compared with participants who did not engage in a prior social interaction, participants who engaged in the social interaction showed a significant increase in MR for human actions. In contrast, social interaction did not increase MR for robot actions. Thus, naturalistic social interaction and laboratory action observation tasks appear to involve common MR mechanisms, and recent experience tunes the system to particular agent types.
Anticipated Future Interaction and Conversational Memory Using Participants and Observers.
ERIC Educational Resources Information Center
Benoit, Pamela J.; Benoit, William L.
1994-01-01
Finds that subjects with a choice about whether to interact with their partner again (or with one of the persons they observed) remembered less in general than those expecting to interact with the same person or with a different person. Participants remembered significantly more conversational information using cued recall than observers, and…
Observing the operational significance of discord consumption
NASA Astrophysics Data System (ADS)
Gu, Mile; Chrzanowski, Helen M.; Assad, Syed M.; Symul, Thomas; Modi, Kavan; Ralph, Timothy C.; Vedral, Vlatko; Lam, Ping Koy
2012-09-01
Coherent interactions that generate negligible entanglement can still exhibit unique quantum behaviour. This observation has motivated a search beyond entanglement for a complete description of all quantum correlations. Quantum discord is a promising candidate. Here, we demonstrate that under certain measurement constraints, discord between bipartite systems can be consumed to encode information that can only be accessed by coherent quantum interactions. The inability to access this information by any other means allows us to use discord to directly quantify this `quantum advantage'. We experimentally encode information within the discordant correlations of two separable Gaussian states. The amount of extra information recovered by coherent interaction is quantified and directly linked with the discord consumed during encoding. No entanglement exists at any point of this experiment. Thus we introduce and demonstrate an operational method to use discord as a physical resource.
Busulfan and metronidazole: an often forgotten but significant drug interaction.
Gulbis, Alison M; Culotta, Kirk S; Jones, Roy B; Andersson, Borje S
2011-07-01
To report the case of a clinically significant drug interaction between intravenous busulfan and oral metronidazole observed through busulfan therapeutic drug monitoring (TDM). A 7-year-old boy with a history of myelodysplasia that progressed to acute myeloid leukemia received busulfan with therapeutic drug monitoring (TDM), clofarabine, and thiotepa as a pretransplant conditioning regimen for a cord blood transplant. The patient received metronidazole the day after a busulfan test dose of 0.5 mg/kg was administered. On the day of the first busulfan therapeutic dose, TDM was performed and the clearance of busulfan was significantly decreased by 46%. After 2 doses of busulfan therapy, the course area under the curve was exceeded, requiring discontinuation of busulfan. Metronidazole is not known to affect glutathione or the glutathione S-transferase A1 (GSTA1) enzyme system or cytochrome P450 (CYP) 3A4. Busulfan is a bifunctional alkylating agent widely used in pretransplant conditioning regimens in patients undergoing stem cell transplantation for hematologic malignancies. Busulfan metabolism is best described by hepatic conjugation to glutathione by GSTA1, although some CYP-dependent pathways have been described. Currently there is 1 publication describing the drug interaction between oral busulfan and oral metronidazole, in which concomitant use of metronidazole resulted in higher busulfan trough concentrations and higher risk of veno-occlusive disease. Our case represents a possible drug interaction based on the Horn Drug Interaction Probability Scale. Though the mechanistic basis for this interaction is unknown, the risks and benefits of using metronidazole during and in close proximity to busulfan should be carefully considered and therapeutic alternatives to metronidazole should be used when appropriate.
Duncan, Larissa G.; Coatsworth, J. Douglas; Gayles, Jochebed G.; Geier, Mary H.; Greenberg, Mark T.
2015-01-01
Research on mindful parenting, an extension of mindfulness to the interpersonal domain of parent-child relationships, has been limited by its reliance on self-report assessment. The current study is the first to examine whether observational indices of parent-youth interactions differentiate between high and low levels of self-reported mindful parenting. The Iowa Family Interaction Rating Scales (IFIRS) were used to code interactions between mothers and their 7th grade youth. Mothers drawn from the top and bottom quartiles (n = 375) of a larger distribution of self-reported interpersonal mindfulness in parenting (N = 804) represented clearly defined high and low mindful parenting groups. Discriminant function analysis (DFA) was used to analyze how well six composite IFIRS observational rating variables (e.g., parental warmth, consistent discipline) discriminated between high and low self-reports of mindful parenting. DFA results were cross-validated, with statistically significant canonical correlations found for both subsamples (p < .05). Subsequent independent samples t-tests revealed that group means were significantly different on all six IFIRS composite ratings. Confirmation of the relations between self-report mindful parenting and the observational ratings was also provided through hierarchical regression analyses conducted with a continuous predictor of mindful parenting using the full sample. Thus, the present study provides preliminary evidence for a link between self-reported mindful parenting and observed interactions between parents and youth. PMID:25844494
Field Observations of Coastal Air-Sea Interaction
NASA Astrophysics Data System (ADS)
Ortiz-Suslow, D. G.; Haus, B. K.; Williams, N. J.; Graber, H. C.
2016-12-01
In the nearshore zone wind, waves, and currents generated from different forcing mechanisms converge in shallow water. This can profoundly affect the physical nature of the ocean surface, which can significantly modulate the exchange of momentum, heat, and mass across the air-sea interface. For decades, the focus of air-sea interaction research has been on the open ocean while the shallow water regime has been relatively under-explored. This bears implications for efforts to understand and model various coastal processes, such as mixing, surface transport, and air-sea gas flux. The results from a recent study conducted at the New River Inlet in North Carolina showed that directly measured air-sea flux parameters, such as the atmospheric drag coefficient, are strong functions of space as well as the ambient conditions (i.e. wind speed and direction). The drag is typically used to parameterize the wind stress magnitude. It is generally assumed that the wind direction is the direction of the atmospheric forcing (i.e. wind stress), however significant wind stress steering off of the azimuthal wind direction was observed and was found to be related to the horizontal surface current shear. The authors have just returned from a field campaign carried out within Monterey Bay in California. Surface observations made from two research vessels were complimented by an array of beach and inland flux stations, high-resolution wind forecasts, and satellite image acquisitions. This is a rich data set and several case studies will be analyzed to highlight the importance of various processes for understanding the air-sea fluxes. Preliminary findings show that interactions between the local wind-sea and the shoaling, incident swell can have a profound effect on the wind stress magnitude. The Monterey Bay coastline contains a variety of topographical features and the importance of land-air-sea interactions will also be investigated.
Comparing models of star formation simulating observed interacting galaxies
NASA Astrophysics Data System (ADS)
Quiroga, L. F.; Muñoz-Cuartas, J. C.; Rodrigues, I.
2017-07-01
In this work, we make a comparison between different models of star formation to reproduce observed interacting galaxies. We use observational data to model the evolution of a pair of galaxies undergoing a minor merger. Minor mergers represent situations weakly deviated from the equilibrium configuration but significant changes in star fomation (SF) efficiency can take place, then, minor mergers provide an unique scene to study SF in galaxies in a realistic but yet simple way. Reproducing observed systems also give us the opportunity to compare the results of the simulations with observations, which at the end can be used as probes to characterize the models of SF implemented in the comparison. In this work we compare two different star formation recipes implemented in Gadget3 and GIZMO codes. Both codes share the same numerical background, and differences arise mainly in the star formation recipe they use. We use observations from Pico dos Días and GEMINI telescopes and show how we use observational data of the interacting pair in AM2229-735 to characterize the interacting pair. Later we use this information to simulate the evolution of the system to finally reproduce the observations: Mass distribution, morphology and main features of the merger-induced star formation burst. We show that both methods manage to reproduce roughly the star formation activity. We show, through a careful study, that resolution plays a major role in the reproducibility of the system. In that sense, star formation recipe implemented in GIZMO code has shown a more robust performance. Acknowledgements: This work is supported by Colciencias, Doctorado Nacional - 617 program.
Wave-ice interaction, observed and modelled
NASA Astrophysics Data System (ADS)
Gemmrich, Johannes
2017-04-01
The need for wide-spread, up-to-date sea state predictions and observations in the emerging ice-free Arctic will further increase as the region will open up to marine operations. Wave models for arctic regions have to capture the additional wave physics associated with wave-ice interactions, and different prediction schemes have to be tested against observations. Here we present examples of spatial wave field parameters obtained from TerraSAR-X StripMap swaths in the southern Beaufort Sea taken as part of the "Arctic Sea State and Boundary Layer DRI". Fetch evolution of the significant wave height and length in open waters, and dominant wave lengths and the high frequency cut-off of the wave spectrum in ice are readily extracted from the SAR (synthetic aperture radar) data. A surprising result is that wave evolution in off-ice wind conditions is more rapidly than the fetch evolution in off-land cases, suggesting seeding of the wave field within the ice-covered region.
The Role of Scheduling in Observing Teacher-Child Interactions
ERIC Educational Resources Information Center
Cash, Anne H.; Pianta, Robert C.
2014-01-01
Observational assessment is being used on a large scale to evaluate the quality of interactions between teachers and children in classroom environments. When one performs observations at scale, features of the protocol such as the scheduling of observations can potentially influence observed scores. In this study interactions were observed for 88…
Review of Aerosol–Cloud Interactions: Mechanisms, Significance, and Challenges
DOE Office of Scientific and Technical Information (OSTI.GOV)
Fan, Jiwen; Wang, Yuan; Rosenfeld, Daniel
2016-11-01
Over the past decade, the number of studies that investigate aerosol-cloud interactions has increased considerably. Although tremendous progress has been made to improve our understanding of basic physical mechanisms of aerosol-cloud interactions and reduce their uncertainties in climate forcing, we are still in poor understanding of (1) some of the mechanisms that interact with each other over multiple spatial and temporal scales, (2) the feedback between microphysical and dynamical processes and between local-scale processes and large-scale circulations, and (3) the significance of cloud-aerosol interactions on weather systems as well as regional and global climate. This review focuses on recent theoreticalmore » studies and important mechanisms on aerosol-cloud interactions, and discusses the significances of aerosol impacts on raditative forcing and precipitation extremes associated with different cloud systems. Despite significant understanding has been gained about aerosol impacts on the main cloud types, there are still many unknowns especially associated with various deep convective systems. Therefore, large efforts are needed to escalate our understanding. Future directions should focus on obtaining concurrent measurements of aerosol properties, cloud microphysical and dynamic properties over a range of temporal and spatial scales collected over typical climate regimes and closure studies, as well as improving understanding and parameterizations of cloud microphysics such as ice nucleation, mixed-phase properties, and hydrometeor size and fall speed« less
The interactional significance of formulas in autistic language.
Dobbinson, Sushie; Perkins, Mick; Boucher, Jill
2003-01-01
The phenomenon of echolalia in autistic language is well documented. Whilst much early research dismissed echolalia as merely an indicator of cognitive limitation, later work identified particular discourse functions of echolalic utterances. The work reported here extends the study of the interactional significance of echolalia to formulaic utterances. Audio and video recordings of conversations between the first author and two research participants were transcribed and analysed according to a Conversation Analysis framework and a multi-layered linguistic framework. Formulaic language was found to have predictable interactional significance within the language of an individual with autism, and the generic phenomenon of formulaicity in company with predictable discourse function was seen to hold across the research participants, regardless of cognitive ability. The implications of formulaicity in autistic language for acquisition and processing mechanisms are discussed.
Interactive-Observation in Communicative Disorders.
ERIC Educational Resources Information Center
Hall, Ed; Harris, Ruth
Through interactive-observation, the strengths of the video recorder (actual viewing experience) and the strengths of the computer (capability for feedback, record keeping, and problem analysis) can be combined and used in the preparation of personnel to educate handicapped children and youth. In the area of communicative disorders, accurate…
Interactions between Coronal Mass Ejections Viewed in Coordinated Imaging and In Situ Observations
NASA Technical Reports Server (NTRS)
Liu, Ying D.; Luhmann, Janet G.; Moestl, Christian; Martinez-Oliveros, Juan C.; Bale, Stewart D.; Lin, Robert P.; Harrison, Richard A.; Temmer, Manuela; Webb, David F.; Odstrcil, Dusan
2013-01-01
The successive coronal mass ejections (CMEs) from 2010 July 30 - August 1 present us the first opportunity to study CME-CME interactions with unprecedented heliospheric imaging and in situ observations from multiple vantage points. We describe two cases of CME interactions: merging of two CMEs launched close in time and overtaking of a preceding CME by a shock wave. The first two CMEs on August 1 interact close to the Sun and form a merged front, which then overtakes the July 30 CME near 1 AU, as revealed by wide-angle imaging observations. Connections between imaging observations and in situ signatures at 1 AU suggest that the merged front is a shock wave, followed by two ejecta observed at Wind which seem to have already merged. In situ measurements show that the CME from July 30 is being overtaken by the shock at 1 AU and is significantly compressed, accelerated and heated. The interaction between the preceding ejecta and shock also results in variations in the shock strength and structure on a global scale, as shown by widely separated in situ measurements from Wind and STEREO B. These results indicate important implications of CME-CME interactions for shock propagation, particle acceleration and space weather forecasting.
Evaluation of Aerosol-cloud Interaction in the GISS Model E Using ARM Observations
NASA Technical Reports Server (NTRS)
DeBoer, G.; Bauer, S. E.; Toto, T.; Menon, Surabi; Vogelmann, A. M.
2013-01-01
Observations from the US Department of Energy's Atmospheric Radiation Measurement (ARM) program are used to evaluate the ability of the NASA GISS ModelE global climate model in reproducing observed interactions between aerosols and clouds. Included in the evaluation are comparisons of basic meteorology and aerosol properties, droplet activation, effective radius parameterizations, and surface-based evaluations of aerosol-cloud interactions (ACI). Differences between the simulated and observed ACI are generally large, but these differences may result partially from vertical distribution of aerosol in the model, rather than the representation of physical processes governing the interactions between aerosols and clouds. Compared to the current observations, the ModelE often features elevated droplet concentrations for a given aerosol concentration, indicating that the activation parameterizations used may be too aggressive. Additionally, parameterizations for effective radius commonly used in models were tested using ARM observations, and there was no clear superior parameterization for the cases reviewed here. This lack of consensus is demonstrated to result in potentially large, statistically significant differences to surface radiative budgets, should one parameterization be chosen over another.
Peer interaction in migrant children: observational data and parents' evaluations.
Dikaiou, M
1989-03-01
This study 1) investigates the social behaviors characterizing the interaction between migrants and nonmigrants in both home and host countries, and 2) measures directly the behavior of the child. 2 samples of Greek migrant children, 8-10 years old, were selected. The group from the home country came from 5 villages in the District of Drama in East Macedonia; the group from the receiving country came from 5 areas in the District of Baden-Wurtenberg in West Germany. All subjects were divided into 6 groups (including control groups), for a total of 133 children. The researcher paired each child with a classmate, matched for sex, age, class-achievement, friendship status and parents' financial situation, occupation, and educational level. The task assigned to the children, painting of a free choice theme, focused on children's interactional patterns. The 3 stages of the task were 1) pre-task interview, 2) the painting together of a common picture, and 3) post-interview. Coders categorized the children's behaviors as either friendly-cooperative or unfriendly-uncooperative and noted periods of working alone or working with the playmate. Interviews with mothers or mother substitutes supplemented the direct observation data. Using the Orthogonal Factor Analysis (Principal Factoring with Rotation), significant differences were found on 5 of the 7 composite variables: 1) submissive/friendly behavior, 2) assertive/friendly behavior, 3) assertive/unfriendly behavior, 4) initiative/opinion expression, and 5) solitary play behavior. Using data from the interviews with mothers and mother substitutes, significant differences were found on attention seeking behavior and dependence. Children who have always lived with their parents in West Germany (2nd generation migrants) present a submissive and friendly behavior towards the German playmates' unfriendly activities. Upon returning to the home country, the child is low in assertiveness/unfriendliness, which is a more neutral
Starbursts in interacting galaxies: Observations and models
NASA Technical Reports Server (NTRS)
Bernloehr, Konrad
1990-01-01
Starbursts have been a puzzling field of research for more than a decade. It is evident that they played a significant role in the evolution of many galaxies but still quite little is known about the starburst mechanisms. A way towards a better interpretation of the available data is the comparison with evolution models of starburst. The modelling of starbursts and the fitting of such model starbursts to observed data is discussed. The models were applied to a subset of starburst and post-starburst galaxies in a sample of 30 interacting systems. These galaxies are not ultraluminous far infrared (FIR) galaxies but rather ordinary starburst galaxies with FIR luminosities of a few 10(exp 10) to a few 10(exp 11) solar luminosities.
Observations and reinterpretation of kingfisher-raptor interactions
Kirby, Ronald E.; Fuller, Mark R.
1978-01-01
Reported observations of Belted Kingfisher (Megaceryle alcyon)-raptor interactions have ranged from brief encounters where the kingfisher escaped the raptor and the hawk subsequently flew away to repeated chases (Johnson 1925, McCabe and McCabe 1928, Skinner 1928, Smith 1963). In some repetitive chases, kingfishers appeared to initiate the interaction (McCabe and McCabe 1928, Skinner 1928).
Portouli, Evangelia; Nathanael, Dimitris; Marmaras, Nicolas
2014-01-01
Social interactions with other road users are an essential component of the driving activity and may prove critical in view of future automation systems; still up to now they have received only limited attention in the scientific literature. In this paper, it is argued that drivers base their anticipations about the traffic scene to a large extent on observations of social behaviour of other 'animate human-vehicles'. It is further argued that in cases of uncertainty, drivers seek to establish a mutual situational awareness through deliberate communicative interactions. A linguistic model is proposed for modelling these communicative interactions. Empirical evidence from on-road observations and analysis of concurrent running commentary by 25 experienced drivers support the proposed model. It is suggested that the integration of a social interactions layer based on illocutionary acts in future driving support and automation systems will improve their performance towards matching human driver's expectations. Practitioner Summary: Interactions between drivers on the road may play a significant role in traffic coordination. On-road observations and running commentaries are presented as empirical evidence to support a model of such interactions; incorporation of drivers' interactions in future driving support and automation systems may improve their performance towards matching driver's expectations.
Mother-Father-Infant Interaction: A Naturalistic Observational Study.
ERIC Educational Resources Information Center
Belsky, Jay
1979-01-01
Investigates infant preferences for interaction with mother v father, similarities and differences in maternal and paternal behavior, and the influence of a second parent's presence on parent-infant interaction. Families with infants 15 months of age were observed in their own homes. (Author/SS)
Observations of Traveling Crossflow Resonant Triad Interactions on a Swept Wing
NASA Technical Reports Server (NTRS)
Eppink, Jenna L.; Wlezien, Richard
2012-01-01
Experimental evidence indicates the presence of a triad resonance interaction between traveling crossflow modes in a swept wing flow. Results indicate that this interaction occurs when the stationary and traveling crossflow modes have similar and relatively low amplitudes (approx.1% to 6% of the total freestream velocity). The resonant interaction occurs at instability amplitudes well below those typically known to cause transition, yet transition is observed to occur just downstream of the resonance. In each case, two primary linearly unstable traveling crossflow modes are nonlinearly coupled to a higher frequency linearly stable mode at the sum of their frequencies. The higher-frequency mode is linearly stable and presumed to exist as a consequence of the interaction of the two primary modes. Autoand cross-bicoherence are used to determine the extent of phase-matching between the modes, and wavenumber matching confirms the triad resonant nature of the interaction. The bicoherence results indicate a spectral broadening mechanism and the potential path to early transition. The implications for laminar flow control in swept wing flows are significant. Even if stationary crossflow modes remain subcritical, traveling crossflow interactions can lead to early transition.
Earth observations and photography experiment: Summary of significant results
NASA Technical Reports Server (NTRS)
El-Baz, F.
1978-01-01
Observation and photographic data from the Apollo Soyuz Test Project are analyzed. The discussion is structured according to the fields of investigation including: geology, desert studies, oceanography, hydrology, and meteorology. The data were obtained by: (1) visual observations of selected Earth features, (2) hand-held camera photography to document observations, and (3) stereo mapping photography of areas of significant scientific interest.
CLINICALLY SIGNIFICANT PSYCHOTROPIC DRUG-DRUG INTERACTIONS IN THE PRIMARY CARE SETTING
English, Brett A.; Dortch, Marcus; Ereshefsky, Larry; Jhee, Stanford
2014-01-01
In recent years, the growing numbers of patients seeking care for a wide range of psychiatric illnesses in the primary care setting has resulted in an increase in the number of psychotropic medications prescribed. Along with the increased utilization of psychotropic medications, considerable variability is noted in the prescribing patterns of primary care providers and psychiatrists. Because psychiatric patients also suffer from a number of additional medical comorbidities, the increased utilization of psychotropic medications presents an elevated risk of clinically significant drug interactions in these patients. While life-threatening drug interactions are rare, clinically significant drug interactions impacting drug response or appearance of serious adverse drug reactions have been documented and can impact long-term outcomes. Additionally, the impact of genetic variability on the psychotropic drug’s pharmacodynamics and/or pharmacokinetics may further complicate drug therapy. Increased awareness of clinically relevant psychotropic drug interactions can aid clinicians to achieve optimal therapeutic outcomes in patients in the primary care setting. PMID:22707017
Atmospheric interaction with nanosatellites from observed orbital decay
NASA Astrophysics Data System (ADS)
Macario-Rojas, A.; Smith, K. L.; Crisp, N. H.; Roberts, P. C. E.
2018-06-01
Nanosatellites have gained considerable presence in low Earth orbits wherein the atmospheric interaction with exposed surfaces plays a fundamental role in the evolution of motion. These aspects become relevant with the increasing applicability of nanosatellites to a broader range of missions objectives. This investigation sets out to determine distinctive drag coefficient development and attributes of atmospheric gas-surface interactions in nanosatellites in the common form of standard 3U CubeSats from observed orbital decay. As orbital decay can be measured with relative accuracy, and its mechanism broken down into its constituent sources, the value of drag-related coefficients can be inferred by fitting modelled orbit predictions to observed data wherein the coefficient of interest is the adjusted parameter. The analysis uses the data of ten historical missions with documented passive attitude stabilisation strategies to reduce uncertainties. Findings indicate that it is possible to estimate fitted drag coefficients in CubeSats with physical representativeness. Assessment of atomic oxygen surface coverage derived from the fitted drag coefficients is broadly consistent with theoretical trends. The proposed methodology opens the possibility to assess atmospheric interaction characteristics by using the unprecedented opportunity arising from the numerous observed orbital decay of nanosatellites.
IMAGE Observations of Plasmasphere/Ring Current Interactions
NASA Technical Reports Server (NTRS)
Gallagher, D. L.; Adrian, M. L.; Perez, J.; Sandel, B. R.
2003-01-01
Evidence has been found in IMAGE observations that overlap of the plasmasphere and the ring current may lead to enhanced loss of plasma into the ionosphere. It has long been anticipated that this mixing of plasma leads to coupling and resulting consequences on both populations. Wave generation, pitch angle scattering, and heating are some of the consequences that are anticipated. IMAGE plasmasphere ring current, and auroral observations will be presented and used to explore these interactions and their effects.
Theoretical and Observational Studies of Meteor Interactions with the Ionosphere
2006-06-01
within an order of magnitude. The histograms of scattering mass, calculated from data collected at the ALTAIR rada are contained in Figure 1 . These...RTO-MP-IST-056 12 - 1 UNCLASSIFIED/UNLIMITED UNCLASSIFIED/UNLIMITED Theoretical and Observational Studies of Meteor Interactions with the...Observational Studies of Meteor Interactions with the Ionosphere. In Characterising the Ionosphere (pp. 12- 1 – 12-12). Meeting Proceedings RTO-MP-IST-056
Nieuwesteeg, Anke; Hartman, Esther; Pouwer, Frans; Emons, Wilco; Aanstoot, Henk-Jan; Van Mil, Edgar; Van Bakel, Hedwig
2014-06-10
between |.24| and |.45| for significant correlations and between |.10| and |.23| for non-significant trends). This observation instrument could be used in future research to (a) test whether parent-child interactions are associated with outcomes (like HbA1c levels and psychosocial functioning), and (b) evaluate interventions, aimed at optimizing the quality of parent-child interactions in families with a young child with T1DM.
Lister, Bradford C.; Hanna, Michael H.; Roy, Harry
2007-01-01
Our Introduction to Biology course (BIOL 1010) changed in 2004 from a standard instructor-centered, lecture-homework-exam format to a student-centered format that used Web-enhanced, interactive pedagogy. To measure and compare conceptual learning gains in the traditional course in fall 2003 with a section of the interactive course in fall 2004, we created concept inventories for both evolution and ecology. Both classes were taught by the same instructor who had taught BIOL 1010 since 1976, and each had a similar student composition with comparable biological knowledge. A significant increase in learning gain was observed with the Web-enhanced, interactive pedagogy in evolution (traditional, 0.10; interactive, 0.19; p = 0.024) and ecology (traditional, −0.05; interactive, 0.14; p = 0.000009) when assessment was made unannounced and for no credit in the last week of classes. These results strengthen the case for augmenting or replacing instructor-centered teaching with Web-enhanced, interactive, student-centered teaching. When assessment was made using the final exam in the interactive course, for credit and after studying, significantly greater learning gains were made in evolution (95%, 0.37, p = 0.0001) and ecology (143%, 0.34, p = 0.000003) when compared with learning gains measured without credit or study in the last week of classes. PMID:17785407
Shomaker, Lauren B.; Furman, Wyndol
2010-01-01
This study examined how current parent-adolescent relationship qualities and adolescents’ representations of relationships with parents were related to friendship interactions in 200 adolescent-close friend dyads. Adolescents and friends were observed discussing problems during a series of structured tasks. Negative interactions with mothers were significantly related to adolescents’ greater conflict with friends, poorer focus on tasks, and poorer communication skills. Security of working models (as assessed by interview) was significantly associated with qualities of friendship interactions, whereas security of attachment styles (as assessed by questionnaire) was not. More dismissing (vs. secure) working models were associated with poorer focus on problem discussions and weaker communication skills with friends, even after accounting for gender differences and current parent-adolescent relationship qualities. We discuss possible mechanisms for the observed links between dimensions of parent-adolescent relationships and friendships. We also consider methodological and conceptual differences between working model and style measures of attachment representations. PMID:20174459
Development of an Observational Procedure for Assessment of Parent-Child Interaction.
ERIC Educational Resources Information Center
Cunningham, Jo Lynn; Boger, Robert P.
The feasibility of using an observational rating schedule to elicit information about parent-child interaction was studied. The Parent-Child Interaction Rating Procedure (P-CIRP), focusing specifically on parent-child interaction with a structured teaching task, was developed for this purpose. The interaction setting is teaching the child simple…
Kristensen, Ingeborg H; Trillingsgaard, Tea; Simonsen, Marianne; Kronborg, Hanne
2017-03-01
Health visitors need competences to promote healthy early parent-infant relationships. The aims of this study were to explore whether there are differences between groups of health visitors with and without additional parenting program education in terms of their knowledge of infant-parent interaction and their observation and assessment skills of such interactions. The cross-sectional study included 36 health visitors' certified Marte Meo therapists and 85 health visitors without additional parenting program education. Health visitors' observation skills were measured assessing five video-recorded mother-infant interactions. A questionnaire was used to measure their intention, self-efficacy, and knowledge. More certified Marte Meo therapists than health visitors without additional parenting program education reported a significantly higher mean level of knowledge of the early relationship, 6.42 (95% CI; 6.18-6.66) versus 5.05 (95% CI; 4.86-6.10), p = .04; and more certified Marte Meo therapists than health visitors without additional parenting program education reported a higher mean level of knowledge of infant self-regulation, 2.44 (95% CI; 2.18-2.71) versus 1.83 (95% CI; 1.62-2.03), p < .001. In the latter group, 54% (95% CI; 0.43-0.64) reported a significantly higher need for further education versus 22% (95% CI; 0.11-0.39), p = .001. Compared to health visitors without any parenting program education, health visitors certified as Marte Meo therapists reported a significantly higher frequency of correct assessment of mothers' sensitivity in two of five video-recordings, with 77.78% (95% CI; 0.61-0.87) compared to 45.88% (95% CI; 0.35-0.57) in Video 3, p = .001, and 69.44% (95% CI; 0.52-0.82) compared to 49.41% (95% CI; 0.39-0.60) in Video 4, p = .04, respectively. The results of the present study support the use of video-based education of health visitors to increase their knowledge of and skills in assessing parent-infant interactions. Randomized controlled
Structural mode significance using INCA. [Interactive Controls Analysis computer program
NASA Technical Reports Server (NTRS)
Bauer, Frank H.; Downing, John P.; Thorpe, Christopher J.
1990-01-01
Structural finite element models are often too large to be used in the design and analysis of control systems. Model reduction techniques must be applied to reduce the structural model to manageable size. In the past, engineers either performed the model order reduction by hand or used distinct computer programs to retrieve the data, to perform the significance analysis and to reduce the order of the model. To expedite this process, the latest version of INCA has been expanded to include an interactive graphical structural mode significance and model order reduction capability.
Observations on the interaction of nanomaterials with bacteria
NASA Astrophysics Data System (ADS)
Raja, P. M.; Ajayan, P. M.; Nalamasu, O.; Sharma, A.
2006-05-01
Large scale commercial manufacturing of nanomaterials raises the important issue of their environmental fate. With increased production (estimated to be in million gallon range) the nanomaterial interactions with environmental microbial ecology would be significant. However, there are scant studies that have addressed this concern. It is therefore essential to experimentally determine some fundamental parameters to ascertain any environmental stresses related to microbiological interactions of nanomaterials. There are concerns that such an interaction may be similar to the biogeochemical interactions of asbestos fibers, which continues to be an alarming environmental issue. Carbon nanotubes (CNTs) are newly emerging nanomaterials, with a wide range of potential electronic and medical applications. Though CNTs are dimensionally similar to the mineral fibers, they differ morphologically, and can possess different surface chemistries, capable of complex and varied biological interactions within the environment. In this study, we present experimental data that show discernible effects on microbial morphology, biofilm formation, substrate consumption rates and growth of Escherichia coli in the presence of carbon nanotubes with the aim of developing a fundamental understanding of the environmental implications of CNT-microbial interactions.
ERIC Educational Resources Information Center
Bemis, Katherine A.; Liberty, Paul G.
The Southwestern Cooperative Interaction Observation Schedule (SCIOS) is a classroom observation instrument designed to record pupil-teacher interaction. The classification of pupil behavior is based on Krathwohl's (1964) theory of the three lowest levels of the affective domain. The levels are (1) receiving: the learner should be sensitized to…
Sit, Cindy H P; Lam, Jessica W K; McKenzie, Thomas L
2010-07-01
Interactive electronic games have recently been popularized and are believed to help promote children's physical activity (PA). The purpose of the study was to examine preferences and PA levels during interactive and online electronic games among overweight and nonoverweight boys and girls. Using a modification of the SOFIT, we systematically observed 70 Hong Kong Chinese children (35 boys, 35 girls; 50 nonoverweight, 20 overweight), age 9 to 12 years, during 2 60-minute recreation sessions and recorded their game mode choices and PA levels. During Session One children could play either an interactive or an online electronic bowling game and during Session Two they could play an interactive or an online electronic running game. Children chose to play the games during 94% of session time and split this time between interactive (52%) and online (48%) versions. They engaged in significantly more moderate-to-vigorous physical activity (MVPA) during interactive games than their online electronic versions (70% vs. 2% of game time). Boys and nonoverweight children expended relatively more energy during the interactive games than girls and overweight children, respectively. New-generation interactive games can facilitate physical activity in children, and given the opportunity children may select them over sedentary versions.
Noise in NC-AFM measurements with significant tip–sample interaction
Lübbe, Jannis; Temmen, Matthias
2016-01-01
The frequency shift noise in non-contact atomic force microscopy (NC-AFM) imaging and spectroscopy consists of thermal noise and detection system noise with an additional contribution from amplitude noise if there are significant tip–sample interactions. The total noise power spectral density D Δ f(f m) is, however, not just the sum of these noise contributions. Instead its magnitude and spectral characteristics are determined by the strongly non-linear tip–sample interaction, by the coupling between the amplitude and tip–sample distance control loops of the NC-AFM system as well as by the characteristics of the phase locked loop (PLL) detector used for frequency demodulation. Here, we measure D Δ f(f m) for various NC-AFM parameter settings representing realistic measurement conditions and compare experimental data to simulations based on a model of the NC-AFM system that includes the tip–sample interaction. The good agreement between predicted and measured noise spectra confirms that the model covers the relevant noise contributions and interactions. Results yield a general understanding of noise generation and propagation in the NC-AFM and provide a quantitative prediction of noise for given experimental parameters. We derive strategies for noise-optimised imaging and spectroscopy and outline a full optimisation procedure for the instrumentation and control loops. PMID:28144538
Noise in NC-AFM measurements with significant tip-sample interaction.
Lübbe, Jannis; Temmen, Matthias; Rahe, Philipp; Reichling, Michael
2016-01-01
The frequency shift noise in non-contact atomic force microscopy (NC-AFM) imaging and spectroscopy consists of thermal noise and detection system noise with an additional contribution from amplitude noise if there are significant tip-sample interactions. The total noise power spectral density D Δ f ( f m ) is, however, not just the sum of these noise contributions. Instead its magnitude and spectral characteristics are determined by the strongly non-linear tip-sample interaction, by the coupling between the amplitude and tip-sample distance control loops of the NC-AFM system as well as by the characteristics of the phase locked loop (PLL) detector used for frequency demodulation. Here, we measure D Δ f ( f m ) for various NC-AFM parameter settings representing realistic measurement conditions and compare experimental data to simulations based on a model of the NC-AFM system that includes the tip-sample interaction. The good agreement between predicted and measured noise spectra confirms that the model covers the relevant noise contributions and interactions. Results yield a general understanding of noise generation and propagation in the NC-AFM and provide a quantitative prediction of noise for given experimental parameters. We derive strategies for noise-optimised imaging and spectroscopy and outline a full optimisation procedure for the instrumentation and control loops.
Constraining self-interacting dark matter with scaling laws of observed halo surface densities
NASA Astrophysics Data System (ADS)
Bondarenko, Kyrylo; Boyarsky, Alexey; Bringmann, Torsten; Sokolenko, Anastasia
2018-04-01
The observed surface densities of dark matter halos are known to follow a simple scaling law, ranging from dwarf galaxies to galaxy clusters, with a weak dependence on their virial mass. Here we point out that this can not only be used to provide a method to determine the standard relation between halo mass and concentration, but also to use large samples of objects in order to place constraints on dark matter self-interactions that can be more robust than constraints derived from individual objects. We demonstrate our method by considering a sample of about 50 objects distributed across the whole halo mass range, and by modelling the effect of self-interactions in a way similar to what has been previously done in the literature. Using additional input from simulations then results in a constraint on the self-interaction cross section per unit dark matter mass of about σ/mχlesssim 0.3 cm2/g. We expect that these constraints can be significantly improved in the future, and made more robust, by i) an improved modelling of the effect of self-interactions, both theoretical and by comparison with simulations, ii) taking into account a larger sample of objects and iii) by reducing the currently still relatively large uncertainties that we conservatively assign to the surface densities of individual objects. The latter can be achieved in particular by using kinematic observations to directly constrain the average halo mass inside a given radius, rather than fitting the data to a pre-selected profile and then reconstruct the mass. For a velocity-independent cross-section, our current result is formally already somewhat smaller than the range 0.5‑5 cm2/g that has been invoked to explain potential inconsistencies between small-scale observations and expectations in the standard collisionless cold dark matter paradigm.
The Development of Social Learning in Interactive and Observational Contexts
ERIC Educational Resources Information Center
Matheson, Heath; Moore, Chris; Akhtar, Nameera
2013-01-01
From the first year of life, imitative learning readily occurs in contexts where a demonstrator directly interacts with infants (i.e., "interactive contexts"), and at least by 18 months, imitation will also occur in third-party or observational contexts where infants witness a demonstration by another person that is not directed at them. However,…
Observation of Spin-Polarons in a strongly interacting Fermi liquid
NASA Astrophysics Data System (ADS)
Zwierlein, Martin
2009-03-01
We have observed spin-polarons in a highly imbalanced mixture of fermionic atoms using tomographic RF spectroscopy. Feshbach resonances allow to freely tune the interactions between the two spin states involved. A single spin down atom immersed in a Fermi sea of spin up atoms can do one of two things: For strong attraction, it can form a molecule with exactly one spin up partner, but for weaker interaction it will spread its attraction and surround itself with a collection of majority atoms. This spin down atom ``dressed'' with a spin up cloud constitutes the spin-polaron. We have observed a striking spectroscopic signature of this quasi-particle for various interaction strengths, a narrow peak in the spin down spectrum that emerges above a broad background. The narrow width signals a long lifetime of the spin-polaron, much longer than the collision rate with spin up atoms, as it must be for a proper quasi-particle. The peak position allows to directly measure the polaron energy. The broad pedestal at high energies reveals physics at short distances and is thus ``molecule-like'': It is exactly matched by the spin up spectra. The comparison with the area under the polaron peak allows to directly obtain the quasi-particle weight Z. We observe a smooth transition from polarons to molecules. At a critical interaction strength of 1/kFa = 0.7, the polaron peak vanishes and spin up and spin down spectra exactly match, signalling the formation of molecules. This is the same critical interaction strength found earlier to separate a normal Fermi mixture from a superfluid molecular Bose-Einstein condensate. The spin-polarons determine the low-temperature phase diagram of imbalanced Fermi mixtures. In principle, polarons can interact with each other and should, at low enough temperatures, form a superfluid of p-wave pairs. We will present a first indication for interactions between polarons.
Observation of Interactions in Adolescent Group Therapy: A Mixed Methods Study
Arias-Pujol, Eulàlia; Anguera, M. Teresa
2017-01-01
Group psychotherapy is a useful clinical practice for adolescents with mental health issues. Groups typically consist of young people of similar ages but with different personalities, and this results in a complex communication network. The goal of group psychoanalytic psychotherapy is to improve participants' mentalization abilities, facilitating interactions between peers and their therapist in a safe, containing environment. The main aim of this study was to analyze conversation turn-taking between a lead therapist, a co-therapist, and six adolescents over the course of 24 treatment sessions divided into four blocks over 8 months. We employed a mixed-methods design based on systematic observation, which we consider to be a mixed method itself, as the qualitative data collected in the initial observation phase is transformed into quantitative data and subsequently interpreted qualitatively with the aid of clinical vignettes. The observational methodology design was nomothetic, follow-up, and multidimensional. The choice of methodology is justified as we used an ad-hoc observation instrument combining a field format and a category system. Interobserver agreement was analyzed quantitatively by Cohen's kappa using the free QSEQ5 software program. Once we had confirmed the reliability of the data, these were analyzed by polar coordinate analysis, which is a powerful data reduction technique that provides a vector representation of relationships between categories. The results show significant relationships between the therapist and (1) the activation of turn-taking by the participants and the co-therapist and silence and (2) conversation-facilitating interventions and interventions designed to improve mentalization abilities. Detailed analysis of questions demonstrating interest in others showed how the communication changed from radial interactions stemming from the therapist at the beginning of therapy to circular interactions half way through. Repetition was found
Imaging host-Leishmania interactions: significance in visceral leishmaniasis.
Forestier, C-L
2013-01-01
Leishmaniasis is a neglected disease that is associated with a spectrum of clinical manifestations ranging from self-healing cutaneous lesions to fatal visceral infections, which primarily depends on the parasite species. In visceral leishmaniasis (VL), as opposed to cutaneous leishmaniasis (CL), parasites that infect host cells at the sand fly bite site have the striking ability to disseminate to visceral organs where they proliferate and persist for long periods of time. Imaging the dynamics of the host-Leishmania interaction in VL provides a powerful approach to understanding the mechanisms underlying host cell invasion, Leishmania dissemination and persistence within visceral organs and, to dissecting the immune responses to infection. Therefore, by allowing the visualization of the critical steps involved in the pathogenesis of VL, state-of-the-art microscopy technologies have the great potential to aid in the identification of better intervention strategies for this devastating disease. In this review, we emphasize the current knowledge and the potential significance of imaging technologies in understanding the infection process of visceralizing Leishmania species. Then, we discuss how application of innovative microscopy technologies to the study of VL will provide rich opportunities for investigating host-parasite interactions at a previously unexplored level and elucidating visceral disease-promoting mechanisms. © 2013 John Wiley & Sons Ltd.
In vivo significance of ITK-SLP-76 interaction in cytokine production.
Grasis, Juris A; Guimond, David M; Cam, Nicholas R; Herman, Krystal; Magotti, Paola; Lambris, John D; Tsoukas, Constantine D
2010-07-01
In vitro data have suggested that activation of the inducible T-cell kinase (ITK) requires an interaction with the adaptor protein SLP-76. One means for this interaction involves binding of the ITK SH3 domain to the polyproline-rich (PR) region of SLP-76. However, the biological significance of this association in live cells and the consequences of its disruption have not been demonstrated. Here, we utilized a polyarginine-rich, cell-permeable peptide that represents the portion of the SLP-76 PR region that interacts with the ITK SH3 domain as a competitive inhibitor to disrupt the association between ITK and SLP-76 in live cells. We demonstrate that treatment of cells with this peptide, by either in vitro incubation or intraperitoneal injection of the peptide in mice, inhibits the T-cell receptor (TCR)-induced association between ITK and SLP-76, recruitment and transphosphorylation of ITK, actin polarization at the T-cell contact site, and expression of Th2 cytokines. The inhibition is specific, as indicated by lack of effects by the polyarginine vehicle alone or a scrambled sequence of the cargo peptide. In view of the role of ITK as a regulator of Th2 cytokine expression, the data underscore the significance of ITK as a target for pharmacological intervention.
An integrated model for detecting significant chromatin interactions from high-resolution Hi-C data
Carty, Mark; Zamparo, Lee; Sahin, Merve; González, Alvaro; Pelossof, Raphael; Elemento, Olivier; Leslie, Christina S.
2017-01-01
Here we present HiC-DC, a principled method to estimate the statistical significance (P values) of chromatin interactions from Hi-C experiments. HiC-DC uses hurdle negative binomial regression account for systematic sources of variation in Hi-C read counts—for example, distance-dependent random polymer ligation and GC content and mappability bias—and model zero inflation and overdispersion. Applied to high-resolution Hi-C data in a lymphoblastoid cell line, HiC-DC detects significant interactions at the sub-topologically associating domain level, identifying potential structural and regulatory interactions supported by CTCF binding sites, DNase accessibility, and/or active histone marks. CTCF-associated interactions are most strongly enriched in the middle genomic distance range (∼700 kb–1.5 Mb), while interactions involving actively marked DNase accessible elements are enriched both at short (<500 kb) and longer (>1.5 Mb) genomic distances. There is a striking enrichment of longer-range interactions connecting replication-dependent histone genes on chromosome 6, potentially representing the chromatin architecture at the histone locus body. PMID:28513628
Variability and Predictability of Land-Atmosphere Interactions: Observational and Modeling Studies
NASA Technical Reports Server (NTRS)
Roads, John; Oglesby, Robert; Marshall, Susan; Robertson, Franklin R.
2002-01-01
The overall goal of this project is to increase our understanding of seasonal to interannual variability and predictability of atmosphere-land interactions. The project objectives are to: 1. Document the low frequency variability in land surface features and associated water and energy cycles from general circulation models (GCMs), observations and reanalysis products. 2. Determine what relatively wet and dry years have in common on a region-by-region basis and then examine the physical mechanisms that may account for a significant portion of the variability. 3. Develop GCM experiments to examine the hypothesis that better knowledge of the land surface enhances long range predictability. This investigation is aimed at evaluating and predicting seasonal to interannual variability for selected regions emphasizing the role of land-atmosphere interactions. Of particular interest are the relationships between large, regional and local scales and how they interact to account for seasonal and interannual variability, including extreme events such as droughts and floods. North and South America, including the Global Energy and Water Cycle Experiment Continental International Project (GEWEX GCIP), MacKenzie, and LBA basins, are currently being emphasized. We plan to ultimately generalize and synthesize to other land regions across the globe, especially those pertinent to other GEWEX projects.
Evidence of gravity wave-tidal interaction observed near the summer mesopause at Poker Flat, Alaska
NASA Technical Reports Server (NTRS)
Wang, Ding-Yi; Fritts, David C.
1991-01-01
An analysis of gravity wave-tidal interaction observed near the mesopause by the MST radar at Poker Flat in July of 1986 is presented. The observations revealed daily mean wind maxima of about 60 m/sec westward and 20 m/sec southward with daily mean momentum fluxes, contributed by gravity waves with periods less than 1 hour of 4-5 sq m/sec sq eastward and 1-2 sq m/sec sq northward. Considerable hourly height variability was found to exist for both winds and momentum fluxes. A significant modulation of the fluxes by tidal winds was observed, characterized by out-of-phase correlations over a number of heights.
Chandra Interactive Analysis of Observations (CIAO)
NASA Technical Reports Server (NTRS)
Dobrzycki, Adam
2000-01-01
The Chandra (formerly AXAF) telescope, launched on July 23, 1999, provides X-rays data with unprecedented spatial and spectral resolution. As part of the Chandra scientific support, the Chandra X-ray Observatory Center provides a new data analysis system, CIAO ("Chandra Interactive Analysis of Observations"). We will present the main components of the system: "First Look" analysis; SHERPA: a multi-dimensional, multi-mission modeling and fitting application; Chandra Imaging and Plotting System; Detect package-source detection algorithms; and DM package generic data manipulation tools, We will set up a demonstration of the portable version of the system and show examples of Chandra Data Analysis.
Hot planetary winds near a star: dynamics, wind-wind interactions, and observational signatures
NASA Astrophysics Data System (ADS)
Carroll-Nellenback, Jonathan; Frank, Adam; Liu, Baowei; Quillen, Alice C.; Blackman, Eric G.; Dobbs-Dixon, Ian
2017-04-01
Signatures of 'evaporative' winds from exoplanets on short (hot) orbits around their host star have been observed in a number of systems. In this paper, we present global adaptive mesh refinement simulations that track the launching of the winds, their expansion through the circumstellar environment, and their interaction with a stellar wind. We focus on purely hydrodynamic flows including the anisotropy of the wind launching and explore the orbital/fluid dynamics of the resulting flows in detail. In particular, we find that a combination of the tidal and Coriolis forces strongly distorts the planetary 'Parker' wind creating 'up-orbit' and 'down-orbit' streams. We characterize the flows in terms of their orbital elements that change depending on their launch position on the planet. We find that the anisotropy in the atmospheric temperature leads to significant backflow on to the planet. The planetary wind interacts strongly with the stellar wind creating instabilities that may cause eventual deposition of planetary gas on to the star. We present synthetic observations of both transit and absorption line-structure for our simulations. For our initial conditions, we find that the orbiting wind material produces absorption signatures at significant distances from the planet and substantial orbit-to-orbit variability. Lyα absorption shows red- and blueshifted features out to 70 km s-1. Finally, using semi-analytic models we constrain the effect of radiation pressure, given the approximation of uniform stellar absorption.
Nanoparticle-Protein Interaction: The Significance and Role of Protein Corona.
Ahsan, Saad Mohammad; Rao, Chintalagiri Mohan; Ahmad, Md Faiz
2018-01-01
The physico-chemical properties of nanoparticles, as characterized under idealized laboratory conditions, have been suggested to differ significantly when studied under complex physiological environments. A major reason for this variation has been the adsorption of biomolecules (mainly proteins) on the nanoparticle surface, constituting the so-called "biomolecular corona". The formation of biomolecular corona on the nanoparticle surface has been reported to influence various nanoparticle properties viz. cellular targeting, cellular interaction, in vivo clearance, toxicity, etc. Understanding the interaction of nanoparticles with proteins upon administration in vivo thus becomes important for the development of effective nanotechnology-based platforms for biomedical applications. In this chapter, we describe the formation of protein corona on nanoparticles and the differences arising in its composition due to variations in nanoparticle properties. Also discussed is the influence of protein corona on various nanoparticle activities.
New observational insight on shock interactions toward supernovae and supernova remnants
NASA Astrophysics Data System (ADS)
Kilpatrick, Charles Donald
2016-08-01
required for their evolution over the ˜10 yr baseline they were observed and find B 1.3 - 5.8 mG and ne ≈ 1,000 - 15,000 cm-3. The magnetic field strengths appear enhanced beyond values required by the adiabatic strong shock limit, arguing in favor of other forms of magnetic field amplification in the shock. In Chapter 4, I again discuss Cassiopeia A and interaction between the remnant and nearby MCs as seen at mid-infrared and millimeter wavelengths. I report detection of a SNR-MC interaction and analyze its signatures in broadened molecular lines. I extend this analysis in Chapter 5 to a large survey for SNR-MC interactions in the 12CO J = 2 - 1 line. Although broadened 12CO J = 2 - 1 line emission should be detectable toward virtually all SNR-MC interactions, I find relatively few examples; therefore, the number of interactions is low. This result favors mechanisms other than supernova feedback as the basic trigger for star formation. In addition, I find no significant association between TeV gamma-ray sources and MC interactions, contrary to predictions that SNR-MC interfaces are the primary venues for cosmic ray acceleration. I end this dissertation in Chapter 6 with a brief summary of my results and two extensions of this work: examining the late-time radio light curves of CSM-interacting SNe for signatures of radio synchrotron emission and dense or clumpy CSM at large distances from the progenitor and re-observing SNR-MC interactions in 12CO J = 3 - 2 in order to verify the presence of shock-heated molecular gas and perform a census on the densities and temperatures of post-shock molecular gas.
Observational Study and Parameterization of Aerosol-fog Interactions
NASA Astrophysics Data System (ADS)
Duan, J.; Guo, X.; Liu, Y.; Fang, C.; Su, Z.; Chen, Y.
2014-12-01
Studies have shown that human activities such as increased aerosols affect fog occurrence and properties significantly, and accurate numerical fog forecasting depends on, to a large extent, parameterization of fog microphysics and aerosol-fog interactions. Furthermore, fogs can be considered as clouds near the ground, and enjoy an advantage of permitting comprehensive long-term in-situ measurements that clouds do not. Knowledge learned from studying aerosol-fog interactions will provide useful insights into aerosol-cloud interactions. To serve the twofold objectives of understanding and improving parameterizations of aerosol-fog interactions and aerosol-cloud interactions, this study examines the data collected from fogs, with a focus but not limited to the data collected in Beijing, China. Data examined include aerosol particle size distributions measured by a Passive Cavity Aerosol Spectrometer Probe (PCASP-100X), fog droplet size distributions measured by a Fog Monitor (FM-120), Cloud Condensation Nuclei (CCN), liquid water path measured by radiometers and visibility sensors, along with meteorological variables measured by a Tethered Balloon Sounding System (XLS-Ⅱ) and Automatic Weather Station (AWS). The results will be compared with low-level clouds for similarities and differences between fogs and clouds.
NASA Astrophysics Data System (ADS)
Pan, Zhen; Kaplinghat, Manoj; Knox, Lloyd
2018-05-01
In this paper, we conduct a search in the latest large-scale structure measurements for signatures of the dark matter-dark radiation interaction proposed by Buen-Abad et al. (2015). We show that prior claims of an inference of this interaction at ˜3 σ significance rely on a use of the Sunyaev-Zeldovich cluster mass function that ignores uncertainty in the mass-observable relationship. Including this uncertainty we find that the inferred level of interaction remains consistent with the data, but so does zero interaction; i.e., there is no longer a preference for nonzero interaction. We also point out that inference of the shape and amplitude of the matter power spectrum from Ly α forest measurements is highly inconsistent with the predictions of the Λ CDM model conditioned on Planck cosmic microwave background temperature, polarization, and lensing power spectra, and that the dark matter-dark radiation model can restore that consistency. We also phenomenologically generalize the model of Buen-Abad et al. (2015) to allow for interaction rates with different scalings with temperature, and find that the original scaling is preferred by the data.
The significance of GW-SW interactions for biogeochemical processes in sandy streambeds
NASA Astrophysics Data System (ADS)
Arnon, Shai; De Falco, Natalie; Fox, Aryeh; Laube, Gerrit; Schmidt, Christian; Fleckenstein, Jan; Boano, Fulvio
2015-04-01
Stream-groundwater interactions have a major impact on hyporheic exchange fluxes in sandy streambeds. However, the physical complexity of natural streams has limited our ability to study these types of interactions systematically, and to evaluate their importance to biogeochemical processes and nutrient cycling. In this work we were able to quantify the effect of losing and gaining fluxes on hyporheic exchange and nutrient cycling in homogeneous and heterogeneous streambeds by combining experiments in laboratory flumes and modeling. Tracer experiments for measuring hyporheic exchange were done using dyes and NaCl under various combinations of overlying water velocity and losing or gaining fluxes. Nutrient cycling experiments were conducted after growing a benthic biofilm by spiking with Sodium Benzoate (as a source of labile dissolved organic carbon, DOC) and measuring DOC and oxygen dynamics. The combination of experimental observations and modeling revealed that interfacial transport increases with the streambed hydraulic conductivity and proportional to the square of the overlying water velocity. Hyporheic exchange fluxes under losing and gaining flow conditions were similar, and became smaller when the losing or gaining flux increases. Increasing in streambed hydraulic conductivity led to higher hyporheic fluxes and reduction in the effects of losing and gaining flow conditions to constrain exchange. Despite the evident effect of flow conditions on hyporheic exchange, labile DOC uptake was positively linked to increasing overlying water velocity but was not affected by losing and gaining fluxes. This is because microbial aerobic activity was taking place at the upper few millimeters of the streambed as shown by local oxygen consumption rates, which was measured using microelectrodes. Based on modeling work, it is expected that GW-SW interaction will be more significant for less labile DOC and anaerobic processes. Our results enable us to study systematically
Observations of Intraspecific Interactions of Bobcats in the Southern High Plains of Texas
Ray, James D.; Thurmond, Lena M.; Matlack, Raymond S.; ...
2017-03-29
Bobcats are solitary felines, having minimal interaction between individuals except for mating or rearing of kittens by females. We report observations of non-aggressive interactions observed and photographed among bobcats in an impacted landscape of the Southern High Plains of Texas. Here, these included the temporary mixing of bobcat litters with at least one adult female present, interactions involving related females and a juvenile, a male bobcat in the presence of a nursing female and her kittens, and several adult bobcats accompanied by a juvenile.
Observations of Intraspecific Interactions of Bobcats in the Southern High Plains of Texas
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ray, James D.; Thurmond, Lena M.; Matlack, Raymond S.
Bobcats are solitary felines, having minimal interaction between individuals except for mating or rearing of kittens by females. We report observations of non-aggressive interactions observed and photographed among bobcats in an impacted landscape of the Southern High Plains of Texas. Here, these included the temporary mixing of bobcat litters with at least one adult female present, interactions involving related females and a juvenile, a male bobcat in the presence of a nursing female and her kittens, and several adult bobcats accompanied by a juvenile.
Observation of coherent diffractive charged current interactions of antineutrinos on neon nuclei
NASA Astrophysics Data System (ADS)
Marage, P.; Aderholz, M.; Armenise, N.; Azemoon, T.; Barnham, K. W. J.; Bartley, J. H.; Baton, J. P.; Bertrand, D.; Brisson, V.; Bullock, F. W.; Calicchio, M.; Cooper, A. M.; Chwastowski, J.; Clayton, E. F.; Coghen, T.; Erriquez, O.; Fitch, P. J.; Gerbier, G.; Guy, J.; Hulth, P. O.; Jones, G. T.; Kasper, P.; Kochowski, C.; Leighton-Davies, S.; Middleton, R. P.; Mobayyen, M. M.; Morrison, D. R. O.; Neveu, M.; Nuzzo, S.; O'Neale, S. W.; Parker, M. A.; Petiau, P.; Ruggieri, F.; Sacton, J.; Sansum, R. A.; Simopoulou, E.; Talebzadeh, M.; Vallee, C.; Varvell, K.; Vayaki, A.; Venus, W.; Wells, J.; Wernhard, K. L.; Wittek, W.; Zevgolatakos, E.; WA59 Collaboration
1984-05-01
First observation is reported of semi-inclusive coherent diffractive charged current interactions of antineutrinos on neon nuclei. A sharp peaking towards zero is observed in the | t| distribution of interactions for which the final state charge is 0 and from which only one negative hadron is emitted, unaccompanied by any evidence of nuclear fragmentation or reinteraction. This peak is correlated with high momentum of the outgoing charged hadron and with small values of Q2 and x.
NASA Technical Reports Server (NTRS)
Gruendl, Robert A.; Vogel, Stuart N.; Davis, David S.; Mulchaey, John S.
1993-01-01
We report kinematic observations of H-alpha emission from the spiral galaxy NGC 2276 obtained with a Fabry-Perot Camera. The 'bow shock' appearance and enhanced star formation in NGC 2276 have been attributed by Mulchaey et al. (1993) to a ram-pressure interaction with the dense IGM detected in ROSAT observations of the NGC 2300 group of galaxies. Along the 'bow shock' limb of the galaxy, we observe strong H-alpha emission and significant kinematic perturbations located immediately interior to an abrupt decrease in the scale length of the optical disk. Although ram-pressure forces may be important in the evolution of the outer gaseous disk, the peculiar kinematics and the truncation in the stellar disk are difficult to explain in a ram-pressure model; a more likely cause is tidal interaction, probably with the elliptical galaxy NGC 2300.
Observation and Control of Hamiltonian Chaos in Wave-particle Interaction
NASA Astrophysics Data System (ADS)
Doveil, F.; Elskens, Y.; Ruzzon, A.
2010-11-01
Wave-particle interactions are central in plasma physics. The paradigm beam-plasma system can be advantageously replaced by a traveling wave tube (TWT) to allow their study in a much less noisy environment. This led to detailed analysis of the self-consistent interaction between unstable waves and an either cold or warm electron beam. More recently a test cold beam has been used to observe its interaction with externally excited wave(s). This allowed observing the main features of Hamiltonian chaos and testing a new method to efficiently channel chaotic transport in phase space. To simulate accurately and efficiently the particle dynamics in the TWT and other 1D particle-wave systems, a new symplectic, symmetric, second order numerical algorithm is developed, using particle position as the independent variable, with a fixed spatial step. This contribution reviews : presentation of the TWT and its connection to plasma physics, resonant interaction of a charged particle in electrostatic waves, observation of particle trapping and transition to chaos, test of control of chaos, and description of the simulation algorithm. The velocity distribution function of the electron beam is recorded with a trochoidal energy analyzer at the output of the TWT. An arbitrary waveform generator is used to launch a prescribed spectrum of waves along the 4m long helix of the TWT. The nonlinear synchronization of particles by a single wave, responsible for Landau damping, is observed. We explore the resonant velocity domain associated with a single wave as well as the transition to large scale chaos when the resonant domains of two waves and their secondary resonances overlap. This transition exhibits a devil's staircase behavior when increasing the excitation level in agreement with numerical simulation. A new strategy for control of chaos by building barriers of transport in phase space as well as its robustness is successfully tested. The underlying concepts extend far beyond the
Astronaut observations from lunar orbit and their geologic significance.
NASA Technical Reports Server (NTRS)
El-Baz, F.; Worden, A. M.; Brand, V. D.
1972-01-01
To supplement orbital photography and other remotely sensed data, visual observations were made of 15 lunar surface targets during Apollo mission 15. Among the significant results are (1) characterization of the floor material of Tsiolkovsky as no darker than the average (Eratosthenian) mare material, and interpretration of the lineated unit on the crater rim as a rock avalanche; (2) identification of layers on the wall of the crater Picard, which is probably volcanic in origin, (3) explanation of the ray-excluded zone of the crater Proclus as the result of structurally controlled ray shadowing; (4) observation of cinder cones in the Littrow area with dark haloes that probably are composed of pyroclastic deposits; and (5) recognition that the termini of numerous sinuous rilles in Oceanus Procellarum are flooded with younger mare materials that may have covered older terminal deposits.
ERIC Educational Resources Information Center
Cameron, David Lansing
2014-01-01
Teacher-student interactions in 17 inclusive classrooms were examined using a mixed-methods approach that involved quantitative analysis of interactions recorded during classroom observations and follow-up interviews with seven general educators. Observational findings suggest that classrooms were organised along traditional lines with the vast…
Solubility of methane in water: the significance of the methane-water interaction potential.
Konrad, Oliver; Lankau, Timm
2005-12-15
The influence of the methane-water interaction potential on the value of the Henry constant obtained from molecular dynamics simulations was investigated. The SPC, SPC/E, MSPC/E, and TIP3P potentials were used to describe water and the OPLS-UA and TraPPE potentials for methane. Nonbonding interactions between unlike atoms were calculated both with one of four mixing rules and with our new methane-water interaction potential. The Henry constants obtained from simulations using any of the mixing rules differed significantly from the experimental ones. Good agreement between simulation and experiment was achieved with the new potential over the whole temperature range.
VLA observations of radio sources in interacting galaxy pairs in poor clusters
NASA Technical Reports Server (NTRS)
Batuski, David J.; Hanisch, Robert J.; Burns, Jack O.
1992-01-01
Observations of 16 radio sources in interacting galaxies in 14 poor clusters were made using the Very Large Array in the B configuration at lambda of 6 and 2 cm. These sources had been unresolved in earlier observations at lambda of 21 cm, and were chosen as a sample to determine which of three models for radio source formation actually pertains in interacting galaxies. From the analysis of this sample, the starburst model appears most successful, but the 'central monster' model could pertain in some cases.
Observations on coyote-mule deer interactions at Rocky Flats, Colorado
DOE Office of Scientific and Technical Information (OSTI.GOV)
Alldredge, A.W.; Arthur, W.J. III
1980-01-01
Observations of interactions between coyotes (Canis latrans) and mule deer (Odocoileus hemionus) in N-central Colorado indicated that, upon discovering a coyote close to a herd, mule deer would become alert, bunch together and either flee or pursue the coyote. Two observations of coyotes attacking deer indicated that the rump was the probable point of attack and in one case the deer began a defense using its front hooves.
SHIELD: Observations of Three Candidate Interacting Systems
NASA Astrophysics Data System (ADS)
Ruvolo, Elizabeth; Miazzo, Masao; Cannon, John M.; McNichols, Andrew; Teich, Yaron; Adams, Elizabeth A.; Giovanelli, Riccardo; Haynes, Martha P.; McQuinn, Kristen B.; Salzer, John Joseph; Skillman, Evan D.; Dolphin, Andrew E.; Elson, Edward C.; Haurberg, Nathalie C.; Huang, Shan; Janowiecki, Steven; Jozsa, Gyula; Leisman, Luke; Ott, Juergen; Papastergis, Emmanouil; Rhode, Katherine L.; Saintonge, Amelie; Van Sistine, Angela; Warren, Steven R.
2017-01-01
Abstract:The “Survey of HI in Extremely Low-mass Dwarfs” (SHIELD) is a multiwavelength study of local volume low-mass galaxies. Using the now-complete Arecibo Legacy Fast ALFA (ALFALFA) source catalog, 82 systems are identified that meet distance, line width, and HI flux criteria for being gas-rich, low-mass galaxies. These systems harbor neutral gas reservoirs smaller than 3x10^7 M_sun, thus populating the faint end of the HI mass function with statistical confidence for the first time. In a companion poster, we present new Karl G. Jansky Very Large Array D-configuration HI spectral line observations of 32 previously unobserved galaxies. Three galaxies in that study have been discovered to lie in close angular proximity to more massive galaxies. Here we present VLA HI imaging of these candidate interacting systems. We compare the neutral gas morphology and kinematics with optical images from SDSS. We discuss the frequency of low-mass galaxies undergoing tidal interaction in the complete SHIELD sample.Support for this work was provided by NSF grant 1211683 to JMC at Macalester College.
Normativity and Desirability in Observational Assessments of Family Interaction.
Deal, James E
2018-06-11
Issues of normativity (responding in a typical or average fashion) and desirability (the tendency for raters to endorse positive characteristics rather than neutral or more negative ones) are common in areas of the social sciences that frequently utilize profile correlations to measure dyadic similarity. They have implications for family scholars as well. In the present study, a pre-existing data set was used to make an initial, though limited, investigation into potential confounds of normativity and desirability for macrolevel observational assessments of family interaction. An empirical example is presented using q-sort ratings of family interaction, with variance in observational assessments decomposed into component parts. High levels of both normativity and desirability were found, indicating possible problems in terms of both reliability and validity of assessment. While the results provide an interesting beginning, they are limited due to the use of a q-sort methodology as well as an instrument with limited background and use. These limitations are discussed, as well as alternative interpretations for normativity and desirability and implications for future research. © 2018 Family Process Institute.
Observation of Iron Specific Interaction with a Charge Neutral Phospholipid
NASA Astrophysics Data System (ADS)
Wang, Wenjie; Zhang, Honghu; Feng, Shuren; San Emeterio, Josue; Kuzmenko, Ivan; Nilsen-Hamilton, Marit; Mallapragada, Surya; Vaknin, David
2015-03-01
Using surface sensitive X-ray scattering and spectroscopic techniques we show that phosphatidyl choline (PC) head groups attract positively charged iron ions and complexes even at pH values that are lower than 3. DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) is a zwitterionic lipid typically used as a model system for cell membranes. Within a large pH range (3 -11), it carries a negative charge on the phosphate group and a positive charge on the quaternary ammonium cation, thus appears charge neutral. Further lowering the pH, i.e. adding a proton to the phosphate group, results in a positively charged headgroup. Surprisingly, we detect significant enrichment of iron at the interface of the DPPC monolayer and the aqueous subphase with the pH maintained at 3 or even lower. With a supposedly charge neutral or even positive surface, the observation of surface bound, charge positive iron ions or iron hydroxides is counter-intuitive and suggests iron-specific interaction with the phospholipid headgroup, which is not governed by electrostatic interaction. The effect of the integration of Mms6, a membrane protein that promotes the formation of magnetic nanocrystals, into the DPPC monolayer will also be discussed. Research supported by the U.S. Department of Energy under Contract No. DE-AC02-07CH11358 and DE-AC02-06CH11357.
Three-dimensional disc-satellite interaction: torques, migration, and observational signatures
NASA Astrophysics Data System (ADS)
Arzamasskiy, Lev; Zhu, Zhaohuan; Stone, James M.
2018-04-01
The interaction of a satellite with a gaseous disc results in the excitation of spiral density waves, which remove angular momentum from the orbit. In addition, if the orbit is not coplanar with the disc, three-dimensional effects will excite bending and eccentricity waves. We perform three-dimensional hydrodynamic simulations to study nonlinear disc-satellite interaction in inviscid protoplanetary discs for a variety of orbital inclinations from 0° to 180°. It is well known that three-dimensional effects are important even for zero inclination. In this work, we (1) show that for planets with small inclinations (as in the Solar system), effects such as the total torque and migration rate strongly depend on the inclination and are significantly different (about 2.5 times smaller) from the two-dimensional case, (2) give formulae for the migration rate, inclination damping, and precession rate of planets with different inclination angles in disc with different scale heights, and (3) present the observational signatures of a planet on an inclined orbit with respect to the protoplanetary disc. For misaligned planets, we find good agreement with linear theory in the limit of small inclinations, and with dynamical friction estimates for intermediate inclinations. We find that in the latter case, the dynamical friction force is not parallel to the relative planetary velocity. Overall, the derived formulae will be important for studying exoplanets with obliquity.
Differences and similarities between father-infant interaction and mother-infant interaction.
Yago, Satoshi; Hirose, Taiko; Okamitsu, Motoko; Okabayashi, Yukiko; Hiroi, Kayoko; Nakagawa, Nozomi; Omori, Takahide
2014-03-19
The aim of this study was to compare father-infant interaction with mother-infant interaction, and explore differences and similarities between parents. Related factors for quality of father-infant interaction were also examined. Sixteen pairs of parents with infants aged 0 to 36 months were observed for play interaction between parents and their children. Results suggested no significant differences between parents, but children's interactions were significantly more contingent with fathers than mothers (p =.045). Significant correlations between parents were found in socialemotional growth fostering encouragement for children during interaction (ρ =.73, p =.001). Paternal depressive symptoms were significantly correlated to paternal sensitivity to child's cues (ρ =-.59, p =.017).
Booren, Leslie M; Downer, Jason T; Vitiello, Virginia E
2012-07-01
This descriptive study examined classroom activity settings in relation to children's observed behavior during classroom interactions, child gender, and basic teacher behavior within the preschool classroom. 145 children were observed for an average of 80 minutes during 8 occasions across 2 days using the inCLASS, an observational measure that conceptualizes behavior into teacher, peer, task, and conflict interactions. Findings indicated that on average children's interactions with teachers were higher in teacher-structured settings, such as large group. On average, children's interactions with peers and tasks were more positive in child-directed settings, such as free choice. Children experienced more conflict during recess and routines/transitions. Finally, gender differences were observed within small group and meals. The implications of these findings might encourage teachers to be thoughtful and intentional about what types of support and resources are provided so children can successfully navigate the demands of particular settings. These findings are not meant to discourage certain teacher behaviors or imply value of certain classroom settings; instead, by providing an evidenced-based picture of the conditions under which children display the most positive interactions, teachers can be more aware of choices within these settings and have a powerful way to assist in professional development and interventions.
Dynamics of interacting quintessence models: Observational constraints
NASA Astrophysics Data System (ADS)
Olivares, Germán; Atrio-Barandela, Fernando; Pavón, Diego
2008-03-01
Interacting quintessence models have been proposed to explain or, at least, alleviate the coincidence problem of late cosmic acceleration. In this paper we are concerned with two aspects of these kind of models: (i) the dynamical evolution of the model of Chimento et al. [L. P. Chimento, A. S. Jakubi, D. Pavón, and W. Zimdahl, Phys. Rev. D 67, 083513 (2003).PRVDAQ0556-282110.1103/PhysRevD.67.083513], i.e., whether its cosmological evolution gives rise to a right sequence of radiation, dark matter, and dark energy dominated eras, and (ii) whether the dark matter dark energy ratio asymptotically evolves towards a nonzero constant. After showing that the model correctly reproduces these eras, we correlate three data sets that constrain the interaction at three redshift epochs: z≤104, z=103, and z=1. We discuss the model selection and argue that even if the model under consideration fulfills both requirements, it is heavily constrained by observation. The prospects that the coincidence problem can be explained by the coupling of dark matter to dark energy are not clearly favored by the data.
Associations between Observed Mother-Adolescent Interactions and Adolescent Information Management
ERIC Educational Resources Information Center
Rote, Wendy M.; Smetana, Judith G.; Campione-Barr, Nicole; Villalobos, Myriam; Tasopoulos-Chan, Marina
2012-01-01
Associations between observed mother-adolescent interactions during a conflict task and adolescents' information management strategies were examined in 108 primarily middle class, European-American adolescents (M = 13.80 years, SD = 1.52) and their mothers. Teens who communicated more clearly disclosed more about personal and multifaceted…
Observation of Hamiltonian chaos and its control in wave particle interaction
NASA Astrophysics Data System (ADS)
Doveil, F.; Macor, A.; Aïssi, A.
2007-12-01
Wave-particle interactions are central in plasma physics. They can be studied in a traveling wave tube (TWT) to avoid intrinsic plasma noise. This led to detailed experimental analysis of the self-consistent interaction between unstable waves and an either cold or warm beam. More recently a test cold electron beam has been used to observe its non-self-consistent interaction with externally excited wave(s). The velocity distribution function of the electron beam is recorded with a trochoidal energy analyzer at the output of the TWT. An arbitrary waveform generator is used to launch a prescribed spectrum of waves along the slow wave structure (a 4 m long helix) of the TWT. The nonlinear synchronization of particles by a single wave responsible for Landau damping is observed. The resonant velocity domain associated with a single wave is also observed, as well as the transition to large scale chaos when the resonant domains of two waves and their secondary resonances overlap. This transition exhibits a 'devil's staircase' behavior when increasing the excitation amplitude in agreement with numerical simulation. A new strategy for control of chaos by building barriers of transport which prevent electrons from escaping from a given velocity region as well as its robustness are successfully tested. The underlying concepts extend far beyond the field of electron devices and plasma physics.
Wungwattana, Minkey; Savic, Marizela
2017-04-01
Tacrolimus (TAC) is subject to many drug interactions as a result of its metabolism primarily via CYP450 isoenzyme 3A4. Numerous case reports of TAC and CYP3A4 inducers and inhibitors have been described including antimicrobials, calcium channel antagonists, and antiepileptic drugs. We present the case of a 13-year-old patient with cystic fibrosis and a history of liver transplantation, where subtherapeutic TAC concentrations were suspected to be a result of concomitant TAC and nafcillin (NAF) therapy. The observed drug interaction occurred on two separate hospital admissions, during both of which the patient exhibited therapeutic TAC concentrations prior to exposure to NAF, a CYP3A4 inducer. Upon discontinuation of NAF, TAC concentrations recovered in both instances. This case represents a drug-drug interaction between TAC and NAF that has not previously been reported to our knowledge. Despite the lack of existing reports of interaction between these two agents, this case highlights the importance of therapeutic drug monitoring and assessing for any potential drug-drug or drug-food interactions in patients receiving TAC therapy. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Holland, David O; Johnson, Margaret E
2018-03-01
Stoichiometric balance, or dosage balance, implies that proteins that are subunits of obligate complexes (e.g. the ribosome) should have copy numbers expressed to match their stoichiometry in that complex. Establishing balance (or imbalance) is an important tool for inferring subunit function and assembly bottlenecks. We show here that these correlations in protein copy numbers can extend beyond complex subunits to larger protein-protein interactions networks (PPIN) involving a range of reversible binding interactions. We develop a simple method for quantifying balance in any interface-resolved PPINs based on network structure and experimentally observed protein copy numbers. By analyzing such a network for the clathrin-mediated endocytosis (CME) system in yeast, we found that the real protein copy numbers were significantly more balanced in relation to their binding partners compared to randomly sampled sets of yeast copy numbers. The observed balance is not perfect, highlighting both under and overexpressed proteins. We evaluate the potential cost and benefits of imbalance using two criteria. First, a potential cost to imbalance is that 'leftover' proteins without remaining functional partners are free to misinteract. We systematically quantify how this misinteraction cost is most dangerous for strong-binding protein interactions and for network topologies observed in biological PPINs. Second, a more direct consequence of imbalance is that the formation of specific functional complexes depends on relative copy numbers. We therefore construct simple kinetic models of two sub-networks in the CME network to assess multi-protein assembly of the ARP2/3 complex and a minimal, nine-protein clathrin-coated vesicle forming module. We find that the observed, imperfectly balanced copy numbers are less effective than balanced copy numbers in producing fast and complete multi-protein assemblies. However, we speculate that strategic imbalance in the vesicle forming module
Observation of CH⋅⋅⋅π Interactions between Methyl and Carbonyl Groups in Proteins.
Perras, Frédéric A; Marion, Dominique; Boisbouvier, Jérôme; Bryce, David L; Plevin, Michael J
2017-06-19
Protein structure and function is dependent on myriad noncovalent interactions. Direct detection and characterization of these weak interactions in large biomolecules, such as proteins, is experimentally challenging. Herein, we report the first observation and measurement of long-range "through-space" scalar couplings between methyl and backbone carbonyl groups in proteins. These J couplings are indicative of the presence of noncovalent C-H⋅⋅⋅π hydrogen-bond-like interactions involving the amide π network. Experimentally detected scalar couplings were corroborated by a natural bond orbital analysis, which revealed the orbital nature of the interaction and the origins of the through-space J couplings. The experimental observation of this type of CH⋅⋅⋅π interaction adds a new dimension to the study of protein structure, function, and dynamics by NMR spectroscopy. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
ERIC Educational Resources Information Center
Tisak, Marie S.; And Others
1996-01-01
Observed preschool children's social interactions with teachers and peers in the context of moral and prudential events. Four types of moral transgressions were observed--physical harm, psychological harm, property loss, and property damage--with the majority of transgressions pertaining to physical harm and property loss. Found gender differences…
Cardona-Morrell, M; Prgomet, M; Lake, R; Nicholson, M; Harrison, R; Long, J; Westbrook, J; Braithwaite, J; Hillman, K
2016-04-01
High profile safety failures have demonstrated that recognising early warning signs of clinical and physiological deterioration can prevent or reduce harm resulting from serious adverse events. Early warning scoring systems are now routinely used in many places to detect and escalate deteriorating patients. Timely and accurate vital signs monitoring are critical for ensuring patient safety through providing data for early warning scoring systems, but little is known about current monitoring practices. To establish a profile of nurses' vital signs monitoring practices, related dialogue, and adherence to health service protocol in New South Wales, Australia. Direct observations of nurses' working practices were conducted in two wards. The observations focused on times of the day when vital signs were generally measured. Patient interactions were recorded if occurring any time during the observation periods. Participants (n=42) included nursing staff on one chronic disease medical and one acute surgical ward in a large urban teaching hospital in New South Wales. We observed 441 patient interactions. Measurement of vital signs occurred in 52% of interactions. The minimum five vital signs measures required by New South Wales Health policy were taken in only 6-21% of instances of vital signs monitoring. Vital signs were documented immediately on 93% of vitals-taking occasions and documented according to the policy in the patient's chart on 89% of these occasions. Nurse-patient interactions were initiated for the purpose of taking vital signs in 49% of interactions, with nurse-patient discourse observed during 88% of all interactions. Nurse-patient dialogue led to additional care being provided to patients in 12% of interactions. The selection of appropriate vital signs measured and responses to these appears to rely on nurses' clinical judgement or time availability rather than on policy-mandated frequency. The prevalence of incomplete sets of vital signs may limit
Perspectives of Future Satellite Observations for Studying Aerosol-Cloud Interactions
NASA Astrophysics Data System (ADS)
Vane, D. G.; Stephens, G. L.
2008-12-01
There are many studies that examine the effects of aerosol on clouds and the consequence of these effects for climate. Much of the focus of these interactions revolve around two types of indirect effects. Using the A- Train as a resource for studying these interactions as a way of defining the requirements for future new missions, we find that the sensitivity of the cloud albedo, as observed by CERES, to aerosol varies according to these various conditions and does not simply correlate with decreased particle size as is typically assumed. It is clear that these effects require more in-depth information about cloud water path, and the occurrence and amount of precipitation and the environmental conditions in which the interactions take place. Information about the motions in clouds, the depths of clouds and more resolved microphysical details on cloud and drizzle are essential to study these effects. Perhaps more important than indirect effects on cloud albedo are the possible effects of aerosol on precipitation. There is much speculation about such influences and the A-Train observations are beginning to reveal much insight on such effects. These observations appear to suggest that the effects on shallow clouds is to delay precipitation production and reduce rainfall as has been speculated. The effects of aerosol on the precipitation falling from deep convection is less clear and more difficult to observe, although many model studies consistently suggest that the effects might be even more pronounced than on shallow convection through, among other mechanisms, the invigoration of storms via freezing of elevated water contents in updrafts. Such studies are now clearly pointing to the need to define the water contents and microphysics of hydrometeors in convective updrafts. This talk draws on these results as a way of framing the definition of the cloud-aerosol and precipitation component of the ACE mission of the decadal survey. This mission represents the follow
ERIC Educational Resources Information Center
Browne, Dillon T.; Leckie, George; Prime, Heather; Perlman, Michal; Jenkins, Jennifer M.
2016-01-01
The present study sought to investigate the family, individual, and dyad-specific contributions to observed cognitive sensitivity during family interactions. Moreover, the influence of cumulative risk on sensitivity at the aforementioned levels of the family was examined. Mothers and 2 children per family were observed interacting in a round robin…
Observation of two-orbital spin-exchange interactions with ultracold SU(N)-symmetric fermions
NASA Astrophysics Data System (ADS)
Scazza, F.; Hofrichter, C.; Höfer, M.; de Groot, P. C.; Bloch, I.; Fölling, S.
2014-10-01
Spin-exchanging interactions govern the properties of strongly correlated electron systems such as many magnetic materials. When orbital degrees of freedom are present, spin exchange between different orbitals often dominates, leading to the Kondo effect, heavy fermion behaviour or magnetic ordering. Ultracold ytterbium or alkaline-earth ensembles have attracted much recent interest as model systems for these effects, with two (meta-) stable electronic configurations representing independent orbitals. We report the observation of spin-exchanging contact interactions in a two-orbital SU(N)-symmetric quantum gas realized with fermionic 173Yb. We find strong inter-orbital spin exchange by spectroscopic characterization of all interaction channels and demonstrate SU(N = 6) symmetry within our measurement precision. The spin-exchange process is also directly observed through the dynamic equilibration of spin imbalances between ensembles in separate orbitals. The realization of an SU(N)-symmetric two-orbital Hubbard Hamiltonian opens the route to quantum simulations with extended symmetries and with orbital magnetic interactions, such as the Kondo lattice model.
Booren, Leslie M.; Downer, Jason T.; Vitiello, Virginia E.
2014-01-01
This descriptive study examined classroom activity settings in relation to children’s observed behavior during classroom interactions, child gender, and basic teacher behavior within the preschool classroom. 145 children were observed for an average of 80 minutes during 8 occasions across 2 days using the inCLASS, an observational measure that conceptualizes behavior into teacher, peer, task, and conflict interactions. Findings indicated that on average children’s interactions with teachers were higher in teacher-structured settings, such as large group. On average, children’s interactions with peers and tasks were more positive in child-directed settings, such as free choice. Children experienced more conflict during recess and routines/transitions. Finally, gender differences were observed within small group and meals. The implications of these findings might encourage teachers to be thoughtful and intentional about what types of support and resources are provided so children can successfully navigate the demands of particular settings. These findings are not meant to discourage certain teacher behaviors or imply value of certain classroom settings; instead, by providing an evidenced-based picture of the conditions under which children display the most positive interactions, teachers can be more aware of choices within these settings and have a powerful way to assist in professional development and interventions. PMID:25717282
Progress on wave-ice interactions: satellite observations and model parameterizations
NASA Astrophysics Data System (ADS)
Ardhuin, Fabrice; Boutin, Guillaume; Dumont, Dany; Stopa, Justin; Girard-Ardhuin, Fanny; Accensi, Mickael
2017-04-01
In the open ocean, numerical wave models have their largest errors near sea ice, and, until recently, virtually no wave data was available in the sea ice to. Further, wave-ice interaction processes may play an important role in the Earth system. In particular, waves may break up an ice layer into floes, with significant impact on air-sea fluxes. With thinner Arctic ice, this process may contribut to the growing similarity between Arctic and Antarctic sea ice. In return, the ice has a strong damping impact on the waves that is highly variable and not understood. Here we report progress on parameterizations of waves interacting with a single ice layer, as implemented in the WAVEWATCH III model (WW3 Development Group, 2016), and based on few in situ observations, but extensive data derived from Synthetic Aperture Radars (SARs). Our parameterizations combine three processes. First a parameterization for the energy-conserving scattering of waves by ice floes (assuming isotropic back-scatter), which has very little effect on dominant waves of periods larger than 7 s, consistent with the observed narrow directional spectra and short travel times. Second, we implemented a basal friction below the ice layer (Stopa et al. The Cryosphere, 2016). Third, we use a secondary creep associated with ice flexure (Cole et al. 1998) adapted to random waves. These three processes (scattering, friction and creep) are strongly dependent on the maximum floe size. We have thus included an estimation of the potential floe size based on an ice flexure failure estimation adapted from Williams et al. (2013). This combination of dissipation and scattering is tested against measured patterns of wave height and directional spreading, and evidence of ice break-up, all obtained from SAR imagery (Ardhuin et al. 2017), and some in situ data (Collins et al. 2015). The combination of creep and friction is required to reproduce a strong reduction in wave attenuation in broken ice as observed by Collins
NASA Technical Reports Server (NTRS)
Li, Feng; Vikhliaev, Yury V.; Newman, Paul A.; Pawson, Steven; Perlwitz, Judith; Waugh, Darryn W.; Douglass, Anne R.
2016-01-01
Stratospheric ozone depletion plays a major role in driving climate change in the Southern Hemisphere. To date, many climate models prescribe the stratospheric ozone layer's evolution using monthly and zonally averaged ozone fields. However, the prescribed ozone underestimates Antarctic ozone depletion and lacks zonal asymmetries. In this study we investigate the impact of using interactive stratospheric chemistry instead of prescribed ozone on climate change simulations of the Antarctic and Southern Ocean. Two sets of 1960-2010 ensemble transient simulations are conducted with the coupled ocean version of the Goddard Earth Observing System Model, version 5: one with interactive stratospheric chemistry and the other with prescribed ozone derived from the same interactive simulations. The model's climatology is evaluated using observations and reanalysis. Comparison of the 1979-2010 climate trends between these two simulations reveals that interactive chemistry has important effects on climate change not only in the Antarctic stratosphere, troposphere, and surface, but also in the Southern Ocean and Antarctic sea ice. Interactive chemistry causes stronger Antarctic lower stratosphere cooling and circumpolar westerly acceleration during November-December-January. It enhances stratosphere-troposphere coupling and leads to significantly larger tropospheric and surface westerly changes. The significantly stronger surface wind stress trends cause larger increases of the Southern Ocean Meridional Overturning Circulation, leading to year-round stronger ocean warming near the surface and enhanced Antarctic sea ice decrease.
Histological observation for needle-tissue interactions.
Nakagawa, Yoshiyuki; Koseki, Yoshihiko
2013-01-01
We histologically investigated tissue fractures and deformations caused by ex vivo needle insertions. The tissue was formalin-fixed while the needle remained in the tissue. Following removal of the needle, the tissue was microtomed, stained, and observed microscopically. This method enabled observations of cellular and tissular conditions where deformations caused by needle insertions were approximately preserved. For this study, our novel method presents preliminary findings related with tissue fractures and the orientation of needle blade relative to muscle fibers. When the needle blade was perpendicular to the muscle fiber, transfiber fractures and relatively large longitudinal deformations occurred. When the needle blade was parallel to the muscle fiber, interfiber fractures and relatively small longitudinal deformations occurred. This made a significant difference in the resistance force of the needle insertions.
Observational constraint on the interacting dark energy models including the Sandage-Loeb test
NASA Astrophysics Data System (ADS)
Zhang, Ming-Jian; Liu, Wen-Biao
2014-05-01
Two types of interacting dark energy models are investigated using the type Ia supernova (SNIa), observational data (OHD), cosmic microwave background shift parameter, and the secular Sandage-Loeb (SL) test. In the investigation, we have used two sets of parameter priors including WMAP-9 and Planck 2013. They have shown some interesting differences. We find that the inclusion of SL test can obviously provide a more stringent constraint on the parameters in both models. For the constant coupling model, the interaction term has been improved to be only a half of the original scale on corresponding errors. Comparing with only SNIa and OHD, we find that the inclusion of the SL test almost reduces the best-fit interaction to zero, which indicates that the higher-redshift observation including the SL test is necessary to track the evolution of the interaction. For the varying coupling model, data with the inclusion of the SL test show that the parameter at C.L. in Planck priors is , where the constant is characteristic for the severity of the coincidence problem. This indicates that the coincidence problem will be less severe. We then reconstruct the interaction , and we find that the best-fit interaction is also negative, similar to the constant coupling model. However, for a high redshift, the interaction generally vanishes at infinity. We also find that the phantom-like dark energy with is favored over the CDM model.
Ikkatai, Yuko; Okanoya, Kazuo; Seki, Yoshimasa
2016-07-01
Humans communicate with one another not only face-to-face but also via modern telecommunication methods such as television and video conferencing. We readily detect the difference between people actively communicating with us and people merely acting via a broadcasting system. We developed an animal model of this novel communication method seen in humans to determine whether animals also make this distinction. We built a system for two animals to interact via audio-visual equipment in real-time, to compare behavioral differences between two conditions, an "interactive two-way condition" and a "non-interactive (one-way) condition." We measured birds' responses to stimuli which appeared in these two conditions. We used budgerigars, which are small, gregarious birds, and found that the frequency of vocal interaction with other individuals did not differ between the two conditions. However, body synchrony between the two birds was observed more often in the interactive condition, suggesting budgerigars recognized the difference between these interactive and non-interactive conditions on some level. Copyright © 2016 Elsevier B.V. All rights reserved.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Colaninno, Robin C.; Vourlidas, Angelos, E-mail: robin.colaninno@nrl.navy.mil, E-mail: angelos.vourlidas@jhuapl.edu
2015-12-10
We examine the interaction of three coronal mass ejections (CMEs) that took place on 2012 March 5 at heights less than 20 R{sub ⊙} in the corona. We used a forward fitting model to reconstruct the three-dimensional trajectories and kinematics of the CMEs and determine their interaction in the observations from three viewpoints: Solar and Heliospheric Observatory (SOHO), STEREO-A, and STEREO-B. The first CME (CME-1), a slow-rising eruption near disk center, is already in progress at 02:45 UT when the second CME (CME-2) erupts from AR 11429 on the east limb. These two CMEs are present in the corona not interactingmore » when a third CME (CME-3) erupts from AR 11429 at 03:34 UT. CME-3 has a constant velocity of 1456[±31] km s{sup −1} and drives a shock that is observed as a halo from all viewpoints. We find that the shock driven by CME-3 passed through CME-1 with no observable change in the geometry, trajectory, or velocity of CME-1. However, the elevated temperatures detected in situ when CME-1 reached Earth indicate that the plasma inside CME-1 may have been heated by the passage of the shock. CME-2 is accelerated by CME-3 to more than twice its initial velocity and remains a separate structure ahead of the CME-3 front. CME-2 is deflected 24° northward by CME-3 for a total deflection of 40° from its source region. These results suggest that the collision of CME-2 and CME-3 is superelastic. This work demonstrates the capability and utility of fitting forward models to complex and interacting CMEs observed in the corona from multiple viewpoints.« less
Interaction between Solar Wind and Lunar Magnetic Anomalies observed by Kaguya MAP-PACE
NASA Astrophysics Data System (ADS)
Saito, Yoshifumi; Yokota, Shoichiro; Tanaka, Takaaki; Asamura, Kazushi; Nishino, Masaki; Yamamoto, Tadateru; Uemura, Kota; Tsunakawa, Hideo
2010-05-01
an energy mass spectrometer. IMA measured mass identified ion energy spectra that had never been obtained at 100km altitude polar orbit around the Moon. When Kaguya flew over South Pole Aitken region, where strong magnetic anomalies exist, solar wind ions reflected by magnetic anomalies were observed. These ions had much higher flux than the solar wind protons scattered at the lunar surface. The magnetically reflected ions had nearly the same energy as the incident solar wind ions while the solar wind protons scattered at the lunar surface had slightly lower energy than the incident solar wind ions. At 100km altitude, when the reflected ions were observed, the simultaneously measured electrons were often heated and the incident solar wind ions were sometimes slightly decelerated. At ~50km altitude, when the reflected ions were observed, proton scattering at the lunar surface clearly disappeared. It suggests that there exists an area on the lunar surface where solar wind does not impact. At ~10km altitude, the interaction between the solar wind ions and the lunar magnetic anomalies was remarkable with clear deceleration of the incident solar wind ions and heating of the reflected ions as well as significant heating of the electrons. Calculating velocity moments including density, velocity, temperature of the ions and electrons, we have found that there exists 100km scale regions over strong magnetic anomalies where plasma parameters are quite different from the outside. Solar wind ions observed at 10km altitude show several different behaviors such as deceleration without heating and heating in a limited region inside the magnetic anomalies that may be caused by the magnetic field structure. The deceleration of the solar wind has the same ΔE/q (ΔE : deceleration energy, q: charge) for different species, which constraints the possible mechanisms of the interaction between solar wind and magnetic anomalies.
Bai, Jinbing; Swanson, Kristen M; Santacroce, Sheila J
2018-01-01
Parent interactions with their child can influence the child's pain and distress during painful procedures. Reliable and valid interaction analysis systems (IASs) are valuable tools for capturing these interactions. The extent to which IASs are used in observational research of parent-child interactions is unknown in pediatric populations. To identify and evaluate studies that focus on assessing psychometric properties of initial iterations/publications of observational coding systems of parent-child interactions during painful procedures. To identify and evaluate studies that focus on assessing psychometric properties of initial iterations/publications of observational coding systems of parent-child interactions during painful procedures. Computerized databases searched included PubMed, CINAHL, PsycINFO, Health and Psychosocial Instruments, and Scopus. Timeframes covered from inception of the database to January 2017. Studies were included if they reported use or psychometrics of parent-child IASs. First assessment was whether the parent-child IASs were theory-based; next, using the Society of Pediatric Psychology Assessment Task Force criteria IASs were assigned to one of three categories: well-established, approaching well-established, or promising. A total of 795 studies were identified through computerized searches. Eighteen studies were ultimately determined to be eligible for inclusion in the review and 17 parent-child IASs were identified from these 18 studies. Among the 17 coding systems, 14 were suitable for use in children age 3 years or more; two were theory-based; and 11 included verbal and nonverbal parent behaviors that promoted either child coping or child distress. Four IASs were assessed as well-established; seven approached well-established; and six were promising. Findings indicate a need for the development of theory-based parent-child IASs that consider both verbal and nonverbal parent behaviors during painful procedures. Findings also
Sarkar, Archana; Dutta, Arup; Dhingra, Usha; Dhingra, Pratibha; Verma, Priti; Juyal, Rakesh; Black, Robert E; Menon, Venugopal P; Kumar, Jitendra; Sazawal, Sunil
2006-08-01
In settings in developing countries, children often socialize with multiple socializing agents (peers, siblings, neighbors) apart from their parents, and thus, a measurement of a child's social interactions should be expanded beyond parental interactions. Since the environment plays a role in shaping a child's development, the measurement of child-socializing agents' interactions is important. We developed and used a computerized observational software Behavior and Social Interaction Software (BASIS) with a preloaded coding scheme installed on a handheld Palm device to record complex observations of interactions between children and socializing agents. Using BASIS, social interaction assessments were conducted on 573 preschool children for 1 h in their natural settings. Multiple screens with a set of choices in each screen were designed that included the child's location, broad activity, state, and interactions with child-socializing agents. Data were downloaded onto a computer and systematically analyzed. BASIS, installed on Palm OS (M-125), enabled the recording of the complex interactions of child-socializing agents that could not be recorded with manual forms. Thus, this tool provides an innovative and relatively accurate method for the systematic recording of social interactions in an unrestricted environment.
Source Regions of the Type II Radio Burst Observed During a CME-CME Interaction on 2013 May 22
NASA Technical Reports Server (NTRS)
Makela, P.; Gopalswamy, N.; Reiner, M. J.; Akiyama, S.; Krupar, V.
2016-01-01
We report on our study of radio source regions during the type II radio burst on 2013 May 22 based on direction finding analysis of the Wind/WAVES and STEREO/WAVES (SWAVES) radio observations at decameter-hectometric wavelengths. The type II emission showed an enhancement that coincided with the interaction of two coronal mass ejections (CMEs) launched in sequence along closely spaced trajectories. The triangulation of the SWAVES source directions posited the ecliptic projections of the radio sources near the line connecting the Sun and the STEREO-A spacecraft. The WAVES and SWAVES source directions revealed shifts in the latitude of the radio source, indicating that the spatial location of the dominant source of the type II emission varies during the CME-CME interaction. The WAVES source directions close to 1MHz frequencies matched the location of the leading edge of the primary CME seen in the images of the LASCO/C3 coronagraph. This correspondence of spatial locations at both wavelengths confirms that the CME-CME interaction region is the source of the type II enhancement. Comparison of radio and white-light observations also showed that at lower frequencies scattering significantly affects radio wave propagation.
NASA Technical Reports Server (NTRS)
Redemann, Jens; Wood, R.; Zuidema, P.; Diner, D.; Van Harten, G.; Xu, F.; Cairns, B.; Knobelspiesse, K.; Segal Rozenhaimer, M.
2017-01-01
Southern Africa produces almost a third of the Earths biomass burning (BB) aerosol particles. Particles lofted into the mid-troposphere are transported westward over the South-East (SE) Atlantic, home to one of the three permanent subtropical stratocumulus (Sc) cloud decks in the world. The SE Atlantic stratocumulus deck interacts with the dense layers of BB aerosols that initially overlay the cloud deck, but later subside and often mix into the clouds. These interactions include adjustments to aerosol-induced solar heating and microphysical effects, and their global representation in climate models remains one of the largest uncertainties in estimates of future climate. Hence, new observations over the SE Atlantic have significant implications for regional and global climate change predictions.The low-level clouds in the SE Atlantic have limited vertical extent and therefore present favorable conditions for their exploration with remote sensing. On the other hand, the normal coexistence of BB aerosols and Sc clouds in the same scene also presents significant challenges to conventional remote sensing techniques. We describe first results from NASAs airborne ORACLES (ObseRvations of Aerosols Above Clouds and Their IntEractionS) deployments in September 2016 and August 2017. We emphasize the unique role of polarimetric observations by two instruments, the Research Scanning Polarimeter (RSP) and the Airborne Multi-angle SpectroPolarimeter Imager (AirMSPI), and describe how these instruments help address specific ORACLES science objectives. Initial assessments of polarimetric observation accuracy for key cloud and aerosol properties will be presented, in as far as the preliminary nature of measurements permits.
NASA Technical Reports Server (NTRS)
Redemann, Jens; Wood, R.; Zuidema, P.; Haywood, J.; Luna, B.; Abel, S.
2015-01-01
Southern Africa produces almost a third of the Earth's biomass burning (BB) aerosol particles, yet the fate of these particles and their influence on regional and global climate is poorly understood. Particles lofted into the mid-troposphere are transported westward over the South-East (SE) Atlantic, home to one of the three permanent subtropical Stratocumulus (Sc) cloud decks in the world. The stratocumulus "climate radiators" are critical to the regional and global climate system. They interact with dense layers of BB aerosols that initially overlay the cloud deck, but later subside and are mixed into the clouds. These interactions include adjustments to aerosol-induced solar heating and microphysical effects. As emphasized in the latest IPCC report, the global representation of these aerosol-cloud interaction processes in climate models is one of the largest uncertainty in estimates of future climate. Hence, new observations over the SE Atlantic have significant implications for global climate change scenarios. We discuss the current knowledge of aerosol and cloud property distributions based on satellite observations and sparse suborbital sampling, and describe planned field campaigns in the region. Specifically, we describe the scientific objectives and implementation of the following four synergistic, international research activities aimed at providing a process-level understanding of aerosol-cloud interactions over the SE Atlantic: 1) ORACLES (Observations of Aerosols above Clouds and their interactions), a five-year investigation between 2015 and 2019 with three Intensive Observation Periods (IOP), recently funded by the NASA Earth-Venture Suborbital Program, 2) CLARIFY-2016 (Cloud-Aerosol-Radiation Interactions and Forcing: Year 2016), a comprehensive observational and modeling programme funded by the UK's Natural Environment Research Council (NERC), and supported by the UK Met Office. 3) LASIC (Layered Atlantic Smoke Interactions with Clouds), a funded
2018-01-01
Stoichiometric balance, or dosage balance, implies that proteins that are subunits of obligate complexes (e.g. the ribosome) should have copy numbers expressed to match their stoichiometry in that complex. Establishing balance (or imbalance) is an important tool for inferring subunit function and assembly bottlenecks. We show here that these correlations in protein copy numbers can extend beyond complex subunits to larger protein-protein interactions networks (PPIN) involving a range of reversible binding interactions. We develop a simple method for quantifying balance in any interface-resolved PPINs based on network structure and experimentally observed protein copy numbers. By analyzing such a network for the clathrin-mediated endocytosis (CME) system in yeast, we found that the real protein copy numbers were significantly more balanced in relation to their binding partners compared to randomly sampled sets of yeast copy numbers. The observed balance is not perfect, highlighting both under and overexpressed proteins. We evaluate the potential cost and benefits of imbalance using two criteria. First, a potential cost to imbalance is that ‘leftover’ proteins without remaining functional partners are free to misinteract. We systematically quantify how this misinteraction cost is most dangerous for strong-binding protein interactions and for network topologies observed in biological PPINs. Second, a more direct consequence of imbalance is that the formation of specific functional complexes depends on relative copy numbers. We therefore construct simple kinetic models of two sub-networks in the CME network to assess multi-protein assembly of the ARP2/3 complex and a minimal, nine-protein clathrin-coated vesicle forming module. We find that the observed, imperfectly balanced copy numbers are less effective than balanced copy numbers in producing fast and complete multi-protein assemblies. However, we speculate that strategic imbalance in the vesicle forming module
A procedure for the significance testing of unmodeled errors in GNSS observations
NASA Astrophysics Data System (ADS)
Li, Bofeng; Zhang, Zhetao; Shen, Yunzhong; Yang, Ling
2018-01-01
It is a crucial task to establish a precise mathematical model for global navigation satellite system (GNSS) observations in precise positioning. Due to the spatiotemporal complexity of, and limited knowledge on, systematic errors in GNSS observations, some residual systematic errors would inevitably remain even after corrected with empirical model and parameterization. These residual systematic errors are referred to as unmodeled errors. However, most of the existing studies mainly focus on handling the systematic errors that can be properly modeled and then simply ignore the unmodeled errors that may actually exist. To further improve the accuracy and reliability of GNSS applications, such unmodeled errors must be handled especially when they are significant. Therefore, a very first question is how to statistically validate the significance of unmodeled errors. In this research, we will propose a procedure to examine the significance of these unmodeled errors by the combined use of the hypothesis tests. With this testing procedure, three components of unmodeled errors, i.e., the nonstationary signal, stationary signal and white noise, are identified. The procedure is tested by using simulated data and real BeiDou datasets with varying error sources. The results show that the unmodeled errors can be discriminated by our procedure with approximately 90% confidence. The efficiency of the proposed procedure is further reassured by applying the time-domain Allan variance analysis and frequency-domain fast Fourier transform. In summary, the spatiotemporally correlated unmodeled errors are commonly existent in GNSS observations and mainly governed by the residual atmospheric biases and multipath. Their patterns may also be impacted by the receiver.
Observational Evidence for Tidal Interaction in Close Binary Systems
NASA Astrophysics Data System (ADS)
Mazeh, T.
This paper reviews the rich corpus of observational evidence for tidal effects, mostly based on photometric and radial-velocity measurements. This is done in a period when the study of binaries is being revolutionized by large-scaled photometric surveys that are detecting many thousands of new binaries and tens of extrasolar planets. We begin by examining the short-term effects, such as ellipsoidal variability and apsidal motion. We next turn to the long-term effects, of which circularization was studied the most: a transition period between circular and eccentric orbits has been derived for eight coeval samples of binaries. The study of synchronization and spin-orbit alignment is less advanced. As binaries are supposed to reach synchronization before circularization, one can expect finding eccentric binaries in pseudo-synchronization state, the evidence for which is reviewed. We also discuss synchronization in PMS and young stars, and compare the emerging timescale with the circularization timescale. We next examine the tidal interaction in close binaries that are orbited by a third distant companion, and review the effect of pumping the binary eccentricity by the third star. We elaborate on the impact of the pumped eccentricity on the tidal evolution of close binaries residing in triple systems, which may shrink the binary separation. Finally we consider the extrasolar planets and the observational evidence for tidal interaction with their parent stars. This includes a mechanism that can induce radial drift of short-period planets, either inward or outward, depending on the planetary radial position relative to the corotation radius. Another effect is the circularization of planetary orbits, the evidence for which can be found in eccentricity-versus-period plot of the planets already known. Whenever possible, the paper attempts to address the possible confrontation between theory and observations, and to point out noteworthy cases and observations that can be
Global observations of aerosol-cloud-precipitation-climate interactions
NASA Astrophysics Data System (ADS)
Rosenfeld, Daniel; Andreae, Meinrat O.; Asmi, Ari; Chin, Mian; de Leeuw, Gerrit; Donovan, David P.; Kahn, Ralph; Kinne, Stefan; Kivekäs, Niku; Kulmala, Markku; Lau, William; Schmidt, K. Sebastian; Suni, Tanja; Wagner, Thomas; Wild, Martin; Quaas, Johannes
2014-12-01
Cloud drop condensation nuclei (CCN) and ice nuclei (IN) particles determine to a large extent cloud microstructure and, consequently, cloud albedo and the dynamic response of clouds to aerosol-induced changes to precipitation. This can modify the reflected solar radiation and the thermal radiation emitted to space. Measurements of tropospheric CCN and IN over large areas have not been possible and can be only roughly approximated from satellite-sensor-based estimates of optical properties of aerosols. Our lack of ability to measure both CCN and cloud updrafts precludes disentangling the effects of meteorology from those of aerosols and represents the largest component in our uncertainty in anthropogenic climate forcing. Ways to improve the retrieval accuracy include multiangle and multipolarimetric passive measurements of the optical signal and multispectral lidar polarimetric measurements. Indirect methods include proxies of trace gases, as retrieved by hyperspectral sensors. Perhaps the most promising emerging direction is retrieving the CCN properties by simultaneously retrieving convective cloud drop number concentrations and updraft speeds, which amounts to using clouds as natural CCN chambers. These satellite observations have to be constrained by in situ observations of aerosol-cloud-precipitation-climate (ACPC) interactions, which in turn constrain a hierarchy of model simulations of ACPC. Since the essence of a general circulation model is an accurate quantification of the energy and mass fluxes in all forms between the surface, atmosphere and outer space, a route to progress is proposed here in the form of a series of box flux closure experiments in the various climate regimes. A roadmap is provided for quantifying the ACPC interactions and thereby reducing the uncertainty in anthropogenic climate forcing.
Multi-scale Observation of Biological Interactions of Nanocarriers: from Nano to Macro
Jin, Su-Eon; Bae, Jin Woo; Hong, Seungpyo
2010-01-01
Microscopic observations have played a key role in recent advancements in nanotechnology-based biomedical sciences. In particular, multi-scale observation is necessary to fully understand the nano-bio interfaces where a large amount of unprecedented phenomena have been reported. This review describes how to address the physicochemical and biological interactions of nanocarriers within the biological environments using microscopic tools. The imaging techniques are categorized based on the size scale of detection. For observation of the nano-scale biological interactions of nanocarriers, we discuss atomic force microscopy (AFM), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). For the micro to macro-scale (in vitro and in vivo) observation, we focus on confocal laser scanning microscopy (CLSM) as well as in vivo imaging systems such as magnetic resonance imaging (MRI), superconducting quantum interference devices (SQUIDs), and IVIS®. Additionally, recently developed combined techniques such as AFM-CLSM, correlative Light and Electron Microscopy (CLEM), and SEM-spectroscopy are also discussed. In this review, we describe how each technique helps elucidate certain physicochemical and biological activities of nanocarriers such as dendrimers, polymers, liposomes, and polymeric/inorganic nanoparticles, thus providing a toolbox for bioengineers, pharmaceutical scientists, biologists, and research clinicians. PMID:20232368
NASA Astrophysics Data System (ADS)
Edwards, B. R.; Belousov, A.; Belousova, M.; Izbekov, P. E.; Bindeman, I. N.; Gardeev, E.; Muravyev, Y. D.; Melnikov, D.
2013-12-01
More than a dozen volcanic eruptions in the past twenty years have produced lava interaction with snow or ice, some of which have produced damaging floods/lahars. However, the factors controlling melting during lava-snow/ice interactions is not well understood. Recent observations from the presently ongoing eruption at Tolbachik, Kamchatka confirm some general observations from large-scale experiments, and recent eruptions (2010 Fimmvorduhals; Edwards et al, 2012), but also show new types of behavior not before described. The new observations provide further constraints on heat transfer between ice/snow and three different lava morphologies: ';a'a, pahoehoe, and toothpaste. ';A'a flows at Tolbachik commonly were able to travel over seasonal snow cover (up to 4 m thick), especially where the snow was covered by tephra within 1.5 km of the vent area. Locally, heated meltwater discharge events issued from beneath the front of advancing lava, even though snow observation pits dug in front of advancing ';a'a flows also showed that in some areas melting was not as extensive. Once, an ';a'a flow was seen to collapse through snow, generating short-lived phreatomagmatic/phreatic activity. Closer to the vent, pahoehoe flow lobes and sheet flows occasionally spilled over onto snow and were able to rapidly transit snow with few obvious signs of melting/steam generation. Most of these flows did melt through basal snow layers within 24 hours however. We were also able to closely observe ';toothpaste' lava flows ';intruding' into snow in several locations, including snow-pits, and to watch it pushing up through snow forming temporary snow domes. Toothpaste lava caused the most rapid melting and most significant volumes of steam, as the meltwater drained down into the intruding lava. Behaviour seen at Tolbachik is similar to historic (e.g., Hekla 1947; Einarrson, 1949) and recent observations (e.g. Fimmvorduhals), as well as large-scale experiments (Edwards et al., 2013). While
Thomas, Andrew S; Elcock, Adrian H
2006-06-21
Proteins and other biomolecules function in cellular environments that contain significant concentrations of dissolved salts and even simple salts such as NaCl can significantly affect both the kinetics and thermodynamics of macromolecular interactions. As one approach to directly observing the effects of salt on molecular associations, explicit-solvent molecular dynamics (MD) simulations have been used here to model the association of pairs of the amino acid analogues acetate and methylammonium in aqueous NaCl solutions of concentrations 0, 0.1, 0.3, 0.5, 1, and 2 M. By performing simulations of 500 ns duration for each salt concentration properly converged estimates of the free energy of interaction of the two molecules have been obtained for all intermolecular separation distances and geometries. The resulting free energy surfaces are shown to give significant new insights into the way salt modulates interactions between molecules containing both charged and hydrophobic groups and are shown to provide valuable new benchmarks for testing the description of salt effects provided by the simpler but faster Poisson-Boltzmann method. In addition, the complex many-dimensional free energy surfaces are shown to be decomposable into a number of one-dimensional effective energy functions. This decomposition (a) allows an unambiguous view of the qualitative differences between the salt dependence of electrostatic and hydrophobic interactions, (b) gives a clear rationalization for why salt exerts different effects on protein-protein association and dissociation rates, and (c) produces simplified energy functions that can be readily used in much faster Brownian dynamics simulations.
ERIC Educational Resources Information Center
Doabler, Christian; Smolkowski, Keith; Fien, Hank; Kosty, Derek B.; Cary, Mari Strand
2010-01-01
In this paper, the authors report research focused directly on the validation of the Coding of Academic Teacher-Student interactions (CATS) direct observation instrument. They use classroom information gathered by the CATS instrument to better understand the potential mediating variables hypothesized to influence student achievement. Their study's…
New analysis of nuclear interaction observed by Mt. Kanbara emulsion chamber experiment
NASA Technical Reports Server (NTRS)
Nanjo, H.
1985-01-01
To date the analysis of the air cascade family has been performed using a full Monte Carlo simulation. It is difficult to draw a definite conclusion about the interaction mechanism by using only this kind of simulation. On the other hand, attempts to reproduce the original gamma ray at the interaction point, for example decascading, have also been made. This method makes it possible to observe the interaction directly and to analyze the data from various angles. All of these methods, however, assume a constant ER in the cascade shower, where E is energy and R is the distance from the center of the cascade shower. It is impossible to reproduce the exact interaction height and energy by these methods. A relative method in separating one cascade shower from others is adopted. This method makes it possible to estimate the interaction height and energy by using information about the lateral spread of the cascade shower.
Observability of planet-disc interactions in CO kinematics
NASA Astrophysics Data System (ADS)
Pérez, Sebastián; Casassus, S.; Benítez-Llambay, P.
2018-06-01
Empirical evidence of planets in gas-rich circumstellar discs is required to constrain giant planet formation theories. Here we study the kinematic patterns which arise from planet-disc interactions and their observability in CO rotational emission lines. We perform three-dimensional hydrodynamical simulations of single giant planets, and predict the emergent intensity field with radiative transfer. Pressure gradients at planet-carved gaps, spiral wakes and vortices bear strong kinematic counterparts. The iso-velocity contours in the CO(2-1) line centroids vo reveal large-scale perturbations, corresponding to abrupt transitions from below sub-Keplerian to super-Keplerian rotation along with radial and vertical flows. The increase in line optical depth at the edge of the gap also modulates vo, but this is a mild effect compared to the dynamical imprint of the planet-disc interaction. The large-scale deviations from the Keplerian rotation thus allow the planets to be indirectly detected via the first moment maps of molecular gas tracers, at ALMA angular resolutions. The strength of these deviations depends on the mass of the perturber. This initial study paves the way to eventually determine the mass of the planet by comparison with more detailed models.
NASA Astrophysics Data System (ADS)
Pandeeswaran, M.; Elango, K. P.
2010-05-01
Spectroscopic studies revealed that the interaction of cimetidine drug with electron acceptors iodine and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) resulted through the initial formation of ionic intermediate to charge transfer (CT) complex. The CT-complexes of the interactions have been characterized using UV-vis, 1H NMR, FT-IR and GC-MS techniques. The formation of triiodide ion, I 3-, is further confirmed by the observation of the characteristic bands in the far IR spectrum for non-linear I 3- ion with C s symmetry at 156 and 131 cm -1 assigned to νas(I-I) and νs(I-I) of the I-I bond and at 73 cm -1 due to bending δ(I 3-). The rate of formation of the CT-complexes has been measured and discussed as a function of relative permittivity of solvent and temperature. The influence of relative permittivity of the medium on the rate indicated that the intermediate is more polar than the reactants and this observation was further supported by spectral studies. Based on the spectroscopic results plausible mechanisms for the interaction of the drug with the chosen acceptors were proposed and discussed and the point of attachment of the multifunctional cimetidine drug with these acceptors during the formation of CT-complex has been established.
SOURCE REGIONS OF THE TYPE II RADIO BURST OBSERVED DURING A CME–CME INTERACTION ON 2013 MAY 22
DOE Office of Scientific and Technical Information (OSTI.GOV)
Mäkelä, P.; Reiner, M. J.; Akiyama, S.
2016-08-20
We report on our study of radio source regions during the type II radio burst on 2013 May 22 based on direction-finding analysis of the Wind /WAVES and STEREO /WAVES (SWAVES) radio observations at decameter–hectometric wavelengths. The type II emission showed an enhancement that coincided with the interaction of two coronal mass ejections (CMEs) launched in sequence along closely spaced trajectories. The triangulation of the SWAVES source directions posited the ecliptic projections of the radio sources near the line connecting the Sun and the STEREO-A spacecraft. The WAVES and SWAVES source directions revealed shifts in the latitude of the radiomore » source, indicating that the spatial location of the dominant source of the type II emission varies during the CME–CME interaction. The WAVES source directions close to 1 MHz frequencies matched the location of the leading edge of the primary CME seen in the images of the LASCO/C3 coronagraph. This correspondence of spatial locations at both wavelengths confirms that the CME–CME interaction region is the source of the type II enhancement. Comparison of radio and white-light observations also showed that at lower frequencies scattering significantly affects radio wave propagation.« less
ERIC Educational Resources Information Center
Parke, Ross D.
This paper presents two studies which explored the manner in which the father interacts with his newborn infant and compared paternal and maternal interaction patterns. In contrast to earlier studies, a direct observational approach was employed that permitted a detailed specification of father behaviors in the presence of the newborn. In the…
An Observational Study of Early Heterosexual Interaction at Middle School Dances
ERIC Educational Resources Information Center
Pellegrini, Anthony D.; Long, Jeffery D.
2007-01-01
In this longitudinal, observational study of heterosexual interaction at middle school dances we examined the degree to which boys' and girls' groups became more gender integrated over time. The results show groups became more integrated over time with the pattern differing by gender. Boys had a relatively low level of contact with girls over the…
Nishida, Ritsuo
2014-01-01
Plants produce a diverse array of secondary metabolites as chemical barriers against herbivores. Many phytophagous insects are highly adapted to these allelochemicals and use such unique substances as the specific host-finding cues, defensive substances of their own, and even as sex pheromones or their precursors by selectively sensing, incorporating, and/or processing these phytochemicals. Insects also serve as pollinators often effectively guided by specific floral fragrances. This review demonstrates the ecological significance of such plant secondary metabolites in the highly diverse interactions between insects and plants.
Wang, B; Abdalla, E; Atrio-Barandela, F; Pavón, D
2016-09-01
Models where dark matter and dark energy interact with each other have been proposed to solve the coincidence problem. We review the motivations underlying the need to introduce such interaction, its influence on the background dynamics and how it modifies the evolution of linear perturbations. We test models using the most recent observational data and we find that the interaction is compatible with the current astronomical and cosmological data. Finally, we describe the forthcoming data sets from current and future facilities that are being constructed or designed that will allow a clearer understanding of the physics of the dark sector.
Shimpi, Priya M; Akhtar, Nameera; Moore, Chris
2013-10-01
Three experiments examined the effects of age and familiarity of a model on toddlers' imitative learning in observational contexts (Experiments 1, 2, and 3) and interactive contexts (Experiments 2 and 3). Experiment 1 (N=112 18-month-old toddlers) varied the age (child vs. adult) and long-term familiarity (kin vs. stranger) of the person who modeled the novel actions. Experiment 2 (N=48 18-month-olds and 48 24-month-olds) and Experiment 3 (N=48 24-month-olds) varied short-term familiarity with the model (some or none) and learning context (interactive or observational). The most striking findings were that toddlers were able to learn a new action from observing completely unfamiliar strangers who did not address them and were far less likely to imitate an unfamiliar model who directly interacted with them. These studies highlight the robustness of toddlers' observational learning and reveal limitations of learning from unfamiliar models in interactive contexts. Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.
Loss of Cbl-PI3K interaction in mice prevents significant bone loss following ovariectomy
Adapala, Naga Suresh; Holland, Danielle; Piccuillo, Vanessa; Barbe, Mary F.; Langdon, Wallace Y.; Tsygankov, Alexander Y.; Lorenzo, Joseph A.; Sanjay, Archana
2014-01-01
Cbl and Cbl-b are E3 ubiquitin ligases and adaptor proteins, which perform regulatory roles in bone remodeling. Cbl−/− mice have delayed bone development due to decreased osteoclast migration. Cbl-b−/− mice are osteopenic due to increased bone resorbing activity of osteoclasts. Unique to Cbl, but not present in Cbl-b, is tyrosine 737 in the YEAM motif, which upon phosphorylation provides a binding site for the regulatory p85 subunit of PI3K. Substitution of tyrosine 737 with phenylalanine (Y737F, CblYF/YF mice) prevents Y737 phosphorylation and abrogates the Cbl-PI3K interaction. We have previously reported that CblYF/YF mice had increased bone volume due to defective bone resorption and increased bone formation. Here we show that the lumbar vertebra from CblYF/YF mice did not have significant bone loss following ovariectomy. Our data also suggests that abrogation of Cbl-PI3K interaction in mice results in the loss of coupling between bone resorption and formation, since ovariectomized CblYF/YF mice did not show significant changes in serum levels of c-terminal telopeptide (CTX), whereas the serum levels of pro-collagen type-1 amino-terminal pro-peptide (P1NP) were decreased. In contrast, following ovariectomy, Cbl−/− and Cbl-b−/− mice showed significant bone loss in tibiae and L2 vertebrae, concomitant with increased serum CTX and P1NP levels. These data indicate that while lack of Cbl or Cbl-b distinctly affects bone remodeling, only the loss of Cbl-PI3K interaction protects mice from significant bone loss following ovariectomy. PMID:24994594
Loss of Cbl-PI3K interaction in mice prevents significant bone loss following ovariectomy.
Adapala, Naga Suresh; Holland, Danielle; Scanlon, Vanessa; Barbe, Mary F; Langdon, Wallace Y; Tsygankov, Alexander Y; Lorenzo, Joseph A; Sanjay, Archana
2014-10-01
Cbl and Cbl-b are E3 ubiquitin ligases and adaptor proteins, which perform regulatory roles in bone remodeling. Cbl-/- mice have delayed bone development due to decreased osteoclast migration. Cbl-b-/- mice are osteopenic due to increased bone resorbing activity of osteoclasts. Unique to Cbl, but not present in Cbl-b, is tyrosine 737 in the YEAM motif, which upon phosphorylation provides a binding site for the regulatory p85 subunit of PI3K. Substitution of tyrosine 737 with phenylalanine (Y737F, CblYF/YF mice) prevents Y737 phosphorylation and abrogates the Cbl-PI3K interaction. We have previously reported that CblYF/YF mice had increased bone volume due to defective bone resorption and increased bone formation. Here we show that the lumbar vertebra from CblYF/YF mice did not have significant bone loss following ovariectomy. Our data also suggests that abrogation of Cbl-PI3K interaction in mice results in the loss of coupling between bone resorption and formation, since ovariectomized CblYF/YF mice did not show significant changes in serum levels of c-terminal telopeptide (CTX), whereas the serum levels of pro-collagen type-1 amino-terminal pro-peptide (P1NP) were decreased. In contrast, following ovariectomy, Cbl-/- and Cbl-b-/- mice showed significant bone loss in the tibiae and L2 vertebrae, concomitant with increased serum CTX and P1NP levels. These data indicate that while lack of Cbl or Cbl-b distinctly affects bone remodeling, only the loss of Cbl-PI3K interaction protects mice from significant bone loss following ovariectomy. Copyright © 2014 Elsevier Inc. All rights reserved.
NASA Technical Reports Server (NTRS)
Herrington, J. R.; Estle, T. L.; Boatner, L. A.
1972-01-01
The observation and interpretation of weak EPR transitions, identified as 'forbidden' transitions, establish the existence of a new type of quadrupole interaction for cubic-symmetry imperfections. This interaction is simply a consequence of the ground-vibronic-state degeneracy. The signs as well as the magnitudes of the quadrupole-coupling coefficients are determined experimentally. These data agree well with the predictions of crystal field theory modified to account for a weak-to-moderate vibronic interaction (i.e., a dynamic Jahn-Teller effect).
NASA Technical Reports Server (NTRS)
Kimura, Yuki; Nuth, Joseph A. III; Ferguson, Frank T.
2005-01-01
Recent measurements of fullerenes and Ti atoms recorded in our laboratory have demonstrated the presence of an infrared feature near 21 pm. The feature observed has nearly the same shape and position as is observed for one of the most enigmatic features in post-asymptotic giant blanch (AGB) stars. In our experimental system large cage carbon particles, such as large fullerenes, were produced from CO gas by the Boudouard reaction. Large-cage carbon particles intermixed with Ti atoms were produced by the evaporation of a Ti metal wrapped carbon electrode in CO gas. The infrared spectra of large fullerenes interacting with Ti atoms show a characteristic feature at 20.3 micron that closely corresponds to the 20.1 micron feature observed in post-AGB stars. Both the lab- oratory and stellar spectra also show a small but significant peak at 19.0 micron, which is attributed to fullerenes. Here, we propose that the interaction between fullerenes and Ti atoms may be a plausible explanation for the 21-micron feature seen in some post-AGB stars.
Approaches to Observe Anthropogenic Aerosol-Cloud Interactions.
Quaas, Johannes
Anthropogenic aerosol particles exert an-quantitatively very uncertain-effective radiative forcing due to aerosol-cloud interactions via an immediate altering of cloud albedo on the one hand and via rapid adjustments by alteration of cloud processes and by changes in thermodynamic profiles on the other hand. Large variability in cloud cover and properties and the therefore low signal-to-noise ratio for aerosol-induced perturbations hamper the identification of effects in observations. Six approaches are discussed as a means to isolate the impact of anthropogenic aerosol on clouds from natural cloud variability to estimate or constrain the effective forcing. These are (i) intentional cloud modification, (ii) ship tracks, (iii) differences between the hemispheres, (iv) trace gases, (v) weekly cycles and (vi) trends. Ship track analysis is recommendable for detailed process understanding, and the analysis of weekly cycles and long-term trends is most promising to derive estimates or constraints on the effective radiative forcing.
Santhoshkumar, Puttur; Udupa, Padmanabha; Murugesan, Raju; Sharma, K. Krishna
2008-01-01
Analysis of aged and cataract lenses shows the presence of increased amounts of crystallin fragments in the high molecular weight aggregates of water-soluble and water-insoluble fractions. However, the significance of accumulation and interaction of low molecular weight crystallin fragments in aging and cataract development is not clearly understood. In this study, 23 low molecular mass (<3.5-kDa) peptides in the urea-soluble fractions of young, aged, and aged cataract human lenses were identified by mass spectroscopy. Two peptides, αB-(1–18) (MDIAIHHPWIRRPFFPFH) and βA3/A1-(59–74) (SD(N)AYHIERLMSFRPIC), present in aged and cataract lens but not young lens, and a third peptide, γS-(167–178) (SPAVQSFRRIVE) present in all three lens groups were synthesized to study the effects of interaction of these peptides with intact α-, β-, and γ-crystallins and alcohol dehydrogenase, a protein used in aggregation studies. Interaction of αB-(1–18) and βA3/A1-(59–74) peptides increased the scattering of light by β- and γ-crystallin and alcohol dehydrogenase. The ability of α-crystallin subunits to function as molecular chaperones was significantly reduced by interaction with αB-(1–18) and βA3/A1-(59–74) peptides, whereas γS peptide had no effect on chaperone-like activity of α-crystallin. The βA3/A1-(59–74 peptide caused a 5.64-fold increase in αB-crystallin oligomeric mass and partial precipitation. Replacing hydrophobic residues in αB-(1–18) and βA3/A1-(59–74) peptides abolished their ability to induce crystallin aggregation and light scattering. Our study suggests that interaction of crystallin-derived peptides with intact crystallins could be a key event in age-related protein aggregation in lens and cataractogenesis. PMID:18227073
Senger, Stefan
2017-04-21
Patents are an important source of information for effective decision making in drug discovery. Encouragingly, freely accessible patent-chemistry databases are now in the public domain. However, at present there is still a wide gap between relatively low coverage-high quality manually-curated data sources and high coverage data sources that use text mining and automated extraction of chemical structures. To secure much needed funding for further research and an improved infrastructure, hard evidence is required to demonstrate the significance of patent-derived information in drug discovery. Surprisingly little such evidence has been reported so far. To address this, the present study attempts to quantify the relevance of patents for formulating and substantiating hypotheses for compound-target interactions. A manually-curated set of 130 compound-target interaction pairs annotated with what are considered to be the earliest patent and publication has been produced. The analysis of this set revealed that in stark contrast to what has been reported for novel chemical structures, only about 10% of the compound-target interaction pairs could be found in publications in the scientific literature within one year of being reported in patents. The average delay across all interaction pairs is close to 4 years. In an attempt to benchmark current capabilities, it was also examined how much of the benefit of using patent-derived information can be retained when a bioannotated version of SureChEMBL is used as secondary source for the patent literature. Encouragingly, this approach found the patents in the annotated set for 72% of the compound-target interaction pairs. Similarly, the effect of using the bioactivity database ChEMBL as secondary source for the scientific literature was studied. Here, the publications from the annotated set were only found for 46% of the compound-target interaction pairs. Patent-derived information is a significant enabler for formulating compound
Cao, Hongjian; Fang, Xiaoyi; Fine, Mark A; Ju, Xiaoyan; Lan, Jing; Liu, Xuanwen
2015-12-01
Employing a multicontext observational design, using a person-centered approach, and treating the marital dyad as the unit of analysis, this study examined the within-couple communication patterning of 144 Chinese newlywed couples and its association with relationship satisfaction. Latent profile analysis consistently revealed 3 profiles of spouses' interactive behaviors across contexts differing in both topic nature (i.e., problem-solving vs. social support) and initiator (i.e., husbands vs. wives): (a) traditionally undemonstrative profile, (b) emotionally quarrelling profile, and (c) warmly supportive profile. The prevalence of communication profiles changed markedly with the nature of the discussion topic and the topic initiator. Further, using latent class analysis, we classified couples into subgroups based on their identified profile memberships across contexts (i.e., consistency of interaction mode across contexts). Three classes were identified: (a) consistently quarrelling class, (b) consistently supportive class, and (c) modestly traditional class. Both the consistently supportive class and the modestly traditional class reported significantly higher levels of marital satisfaction than did the consistently quarrelling class. (c) 2015 APA, all rights reserved).
ERIC Educational Resources Information Center
Doabler, Christian T.; Nelson-Walker, Nancy; Kosty, Derek; Baker, Scott K.; Smolkowski, Keith; Fien, Hank
2013-01-01
In this study, the authors conceptualize teaching episodes such as an integrated set of observable student-teacher interactions. Instructional interactions that take place between teachers and students around critical academic content are a defining characteristic of classroom instruction and a component carefully defined in many education…
Observations of land-atmosphere interactions using satellite data
NASA Astrophysics Data System (ADS)
Green, Julia; Gentine, Pierre; Konings, Alexandra; Alemohammad, Hamed; Kolassa, Jana
2016-04-01
Observations of land-atmosphere interactions using satellite data Julia Green (1), Pierre Gentine (1), Alexandra Konings (1,2), Seyed Hamed Alemohammad (3), Jana Kolassa (4) (1) Columbia University, Earth and Environmental Engineering, NY, NY, USA, (2) Stanford University, Environmental Earth System Science, Stanford, CA, USA, (3) Massachusetts Institute of Technology, Civil and Environmental Engineering, Cambridge, MA, USA, (4) National Aeronautics and Space Administration/Goddard Space Flight Center, Greenbelt, MD, USA. Previous studies of global land-atmosphere hotspots have often relied solely on data from global models with the consequence that they are sensitive to model error. On the other hand, by only analyzing observations, it can be difficult to distinguish causality from mere correlation. In this study, we present a general framework for investigating land-atmosphere interactions using Granger Causality analysis applied to remote sensing data. Based on the near linear relationship between chlorophyll sun induced fluorescence (SIF) and photosynthesis (and thus its relationship with transpiration), we use the GOME-2 fluorescence direct measurements to quantify the surface fluxes between the land and atmosphere. By using SIF data to represent the flux, we bypass the need to use soil moisture data from FLUXNET (limited spatially and temporally) or remote sensing (limited by spatial resolution, canopy interference, measurement depth, and radio frequency interference) thus eliminating additional uncertainty. The Granger Causality analysis allows for the determination of the strength of the two-way causal relationship between SIF and several climatic variables: precipitation, radiation and temperature. We determine that warm regions transitioning from water to energy limitation exhibit strong feedbacks between the land surface and atmosphere due to their high sensitivity to climate and weather variability. Tropical rainforest regions show low magnitudes of
Singh, Anshika; Thakur, Narsinh L
2016-01-05
Marine sessile organisms often inhabit rocky substrata, which are crowded by other sessile organisms. They acquire living space via growth interactions and/or by allelopathy. They are known to secrete toxic compounds having multiple roles. These compounds have been explored for their possible applications in cancer chemotherapy, because of their ability to kill rapidly dividing cells of competitor organisms. As compared to the therapeutic applications of these compounds, their possible ecological role in competition for space has received little attention. To select the potential candidate organisms for the isolation of lead cytotoxic molecules, it is important to understand their chemical ecology with special emphasis on their allelopathic interactions with their competitors. Knowledge of the ecological role of allelopathic compounds will contribute significantly to an understanding of their natural variability and help us to plan effective and sustainable wild harvests to obtain novel cytotoxic chemicals. This review highlights the significance of studying allelopathic interactions of marine invertebrates in the discovery of cytotoxic compounds, by selecting sponge as a model organism. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
ERIC Educational Resources Information Center
Booren, Leslie M.; Downer, Jason T.; Vitiello, Virginia E.
2012-01-01
Research Findings: This descriptive study examined classroom activity settings in relation to children's observed behavior during classroom interactions, child gender, and basic teacher behavior within the preschool classroom. A total of 145 children were observed for an average of 80 min during 8 occasions across 2 days using the Individualized…
Impact of observational incompleteness on the structural properties of protein interaction networks
NASA Astrophysics Data System (ADS)
Kuhnt, Mathias; Glauche, Ingmar; Greiner, Martin
2007-01-01
The observed structure of protein interaction networks is corrupted by many false positive/negative links. This observational incompleteness is abstracted as random link removal and a specific, experimentally motivated (spoke) link rearrangement. Their impact on the structural properties of gene-duplication-and-mutation network models is studied. For the degree distribution a curve collapse is found, showing no sensitive dependence on the link removal/rearrangement strengths and disallowing a quantitative extraction of model parameters. The spoke link rearrangement process moves other structural observables, like degree correlations, cluster coefficient and motif frequencies, closer to their counterparts extracted from the yeast data. This underlines the importance to take a precise modeling of the observational incompleteness into account when network structure models are to be quantitatively compared to data.
Rimac, Hrvoje; Debeljak, Željko; Bojić, Mirza; Miller, Larisa
2017-01-01
Human serum albumin (HSA) is the most abundant protein in human serum. It has numerous functions, one of which is transport of small hydrophobic molecules, including drugs, toxins, nutrients, hormones and metabolites. HSA has the ability to interact with a wide variety of structurally different compounds. This promiscuous, nonspecific affinity can lead to sudden changes in concentrations caused by displacement, when two or more compounds compete for binding to the same molecular site. It is important to consider drug combinations and their binding to HSA when defining dosing regimens, as this can directly influence drug's free, active concentration in blood. In present paper we review drug interactions with potential for displacement from HSA, situations in which they are likely to occur and their clinical significance. We also offer guidelines in designing drugs with decreased binding to HSA. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Significance of Cuscutain, a cysteine protease from Cuscuta reflexa, in host-parasite interactions.
Bleischwitz, Marc; Albert, Markus; Fuchsbauer, Hans-Lothar; Kaldenhoff, Ralf
2010-10-22
Plant infestation with parasitic weeds like Cuscuta reflexa induces morphological as well as biochemical changes in the host and the parasite. These modifications could be caused by a change in protein or gene activity. Using a comparative macroarray approach Cuscuta genes specifically upregulated at the host attachment site were identified. One of the infestation specific Cuscuta genes encodes a cysteine protease. The protein and its intrinsic inhibitory peptide were heterologously expressed, purified and biochemically characterized. The haustoria specific enzyme was named cuscutain in accordance with similar proteins from other plants, e.g. papaya. The role of cuscutain and its inhibitor during the host parasite interaction was studied by external application of an inhibitor suspension, which induced a significant reduction of successful infection events. The study provides new information about molecular events during the parasitic plant--host interaction. Inhibition of cuscutain cysteine proteinase could provide means for antagonizing parasitic plants.
Physiological Significance of Low Atmospheric CO 2 for Plant-Climate Interactions
NASA Astrophysics Data System (ADS)
Cowling, Sharon A.; Sykes, Martin T.
1999-09-01
Methods of palaeoclimate reconstruction from pollen are built upon the assumption that plant-climate interactions remain the same through time or that these interactions are independent of changes in atmospheric CO2. The latter may be problematic because air trapped in polar ice caps indicates that atmospheric CO2 has fluctuated significantly over at least the past 400,000 yr, and likely the last 1.6 million yr. Three other points indicate potential biases for vegetation-based climate proxies. First, C3-plant physiological research shows that the processes that determine growth optima in plants (photosynthesis, mitochondrial respiration, photorespiration) are all highly CO2-dependent, and thus were likely affected by the lower CO2 levels of the last glacial maximum. Second, the ratio of carbon assimilation per unit transpiration (called water-use efficiency) is sensitive to changes in atmospheric CO2 through effects on stomatal conductance and may have altered C3-plant responses to drought. Third, leaf gas-exchange experiments indicate that the response of plants to carbon-depleting environmental stresses are strengthened under low CO2 relative to today. This paper reviews the scope of research addressing the consequences of low atmospheric CO2 for plant and ecosystem processes and highlights why consideration of the physiological effects of low atmospheric CO2 on plant function is recommended for any future refinements to pollen-based palaeoclimatic reconstructions.
Coordinated observations of interacting peculiar red giant binaries, 2
NASA Technical Reports Server (NTRS)
Ake, T.
1995-01-01
IUE and H alpha observations continued on a two-year program to monitor the UV variability of three interacting peculiar red giant (PRG) binaries, HD 59643 (C6,s), HD 35155 (S3/2), and HR 1105 (S3.5/2.5). All of these systems were suspected to involve accretion of material from the PRG to a white-dwarf secondary, based mainly on previous IUE investigations. They were primary candidates from earlier surveys of PRG's to test the hypothesis that the Tc-poor PRG's are formed as a result of mass transfer from a secondary component rather than from internal thermal pulsing while on the asymptotic red giant branch.
Coordinated observations of interacting peculiar red giant binaries, 1
NASA Technical Reports Server (NTRS)
Ake, T.
1995-01-01
IUE Observations were begun for a two-year program to monitor the UV variability of three interacting peculiar red giant (PRG) binaries, HD 59643 (C6,s) HD 35155 (S3/2), and HR 1105 (S3.5/2.5). All of these systems were suspected to involve accretion of material from the PRG to a white-dwarf secondary, based mainly on previous IUE investigations. From our earlier surveys of PRG's, they were primary candidates to test the hypothesis that Tc-poor PRG's are formed as a result of mass transfer from a secondary component rather than from internal thermal pulsing while on the asymptotic red giant branch.
NASA Astrophysics Data System (ADS)
Raghav, Anil N.; Kule, Ankita
2018-05-01
The large-scale magnetic cloud such as coronal mass ejections (CMEs) is the fundamental driver of the space weather. The interaction of the multiple-CMEs in interplanetary space affects their dynamic evolution and geo-effectiveness. The complex and merged multiple magnetic clouds appear as the in situ signature of the interacting CMEs. The Alfvén waves are speculated to be one of the major possible energy exchange/dissipation mechanism during the interaction. However, no such observational evidence has been found in the literature. The case studies of CME-CME collision events suggest that the magnetic and thermal energy of the CME is converted into the kinetic energy. Moreover, magnetic reconnection process is justified to be responsible for merging of multiple magnetic clouds. Here, we present unambiguous evidence of sunward torsional Alfvén waves in the interacting region after the super-elastic collision of multiple CMEs. The Walén relation is used to confirm the presence of Alfvén waves in the interacting region of multiple CMEs/magnetic clouds. We conclude that Alfvén waves and magnetic reconnection are the possible energy exchange/dissipation mechanisms during large-scale magnetic clouds collisions. This study has significant implications not only in CME-magnetosphere interactions but also in the interstellar medium where interactions of large-scale magnetic clouds are possible.
Significance of Cuscutain, a cysteine protease from Cuscuta reflexa, in host-parasite interactions
2010-01-01
Background Plant infestation with parasitic weeds like Cuscuta reflexa induces morphological as well as biochemical changes in the host and the parasite. These modifications could be caused by a change in protein or gene activity. Using a comparative macroarray approach Cuscuta genes specifically upregulated at the host attachment site were identified. Results One of the infestation specific Cuscuta genes encodes a cysteine protease. The protein and its intrinsic inhibitory peptide were heterologously expressed, purified and biochemically characterized. The haustoria specific enzyme was named cuscutain in accordance with similar proteins from other plants, e.g. papaya. The role of cuscutain and its inhibitor during the host parasite interaction was studied by external application of an inhibitor suspension, which induced a significant reduction of successful infection events. Conclusions The study provides new information about molecular events during the parasitic plant - host interaction. Inhibition of cuscutain cysteine proteinase could provide means for antagonizing parasitic plants. PMID:20964874
Endedijk, H M; Meyer, M; Bekkering, H; Cillessen, A H N; Hunnius, S
2017-04-01
Whether we hand over objects to someone, play a team sport, or make music together, social interaction often involves interpersonal action coordination, both during instances of cooperation and entrainment. Neural mirroring is thought to play a crucial role in processing other's actions and is therefore considered important for social interaction. Still, to date, it is unknown whether interindividual differences in neural mirroring play a role in interpersonal coordination during different instances of social interaction. A relation between neural mirroring and interpersonal coordination has particularly relevant implications for early childhood, since successful early interaction with peers is predictive of a more favorable social development. We examined the relation between neural mirroring and children's interpersonal coordination during peer interaction using EEG and longitudinal behavioral data. Results showed that 4-year-old children with higher levels of motor system involvement during action observation (as indicated by lower beta-power) were more successful in early peer cooperation. This is the first evidence for a relation between motor system involvement during action observation and interpersonal coordination during other instances of social interaction. The findings suggest that interindividual differences in neural mirroring are related to interpersonal coordination and thus successful social interaction. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.
A Few Observations and Remarks on Time Effectiveness of Interactive Electronic Testing
ERIC Educational Resources Information Center
Magdin, Martin; Turcáni, Milan
2015-01-01
In the paper, we point out several observations and remarks on time effectiveness of electronic testing, in particular of its new form (interactive tests). A test is often used as an effective didactic tool for evaluating the extent of gained cognitive capabilities. According to authors Rudman (1989) and Wang (2003) it is provable that the…
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ilieva, Yordanka; Cao, Tongtong; Zachariou, Nicholas
2016-06-01
Theoretical studies suggest that experimental observables for hyperon production reactions can place stringent constraints on the free parameters of hyperon-nucleon potentials, which are critical for the understanding of hypernuclear matter and neutron stars. Here we present preliminary experimental results for the polarization observables S, Py, Ox, Oz, Cx, and Cz for final-state interactions (FSI) in exclusive L photoproduction off the deuteron. The observables were obtained from data collected during the E06-103 (g13) experiment with the CEBAF Large Acceptance Spectrometer (CLAS) in Hall B at Jefferson Lab. The g13 experiment ran with unpolarized deuteron target and circularly- and linearly-polarized photon beamsmore » with energies between 0.5 GeV and 2.5 GeV and collected about 51010 events with multiple charged particles in the final state. To select the reaction of interest, the K+ and the L decay products, a proton and a negative pion, were detected in the CLAS. The missing-mass technique was used to identify exclusive hyperon photoproduction events. Final-state interaction events were selected by requesting that the reconstructed neutron has a momentum larger than 200 MeV/c. The large statistics of E06-103 provided statistically meaningful FSI event samples, which allow for the extraction of one- and two-fold differential single- and double-polarization observables. Here we present preliminary results for a set of six observables for photon energies between 0.9 GeV and 2.3 GeV and for several kinematic variables in the Ln center-of-mass frame. Our results are the very first estimates of polarization observables for FSI in hyperon photoproduction and will be used to constrain the free parameters of hyperon-nucleon potentials.« less
Dittmar, John C.; Pierce, Steven; Rothstein, Rodney; Reid, Robert J. D.
2013-01-01
Genome-wide experiments often measure quantitative differences between treated and untreated cells to identify affected strains. For these studies, statistical models are typically used to determine significance cutoffs. We developed a method termed “CLIK” (Cutoff Linked to Interaction Knowledge) that overlays biological knowledge from the interactome on screen results to derive a cutoff. The method takes advantage of the fact that groups of functionally related interacting genes often respond similarly to experimental conditions and, thus, cluster in a ranked list of screen results. We applied CLIK analysis to five screens of the yeast gene disruption library and found that it defined a significance cutoff that differed from traditional statistics. Importantly, verification experiments revealed that the CLIK cutoff correlated with the position in the rank order where the rate of true positives drops off significantly. In addition, the gene sets defined by CLIK analysis often provide further biological perspectives. For example, applying CLIK analysis retrospectively to a screen for cisplatin sensitivity allowed us to identify the importance of the Hrq1 helicase in DNA crosslink repair. Furthermore, we demonstrate the utility of CLIK to determine optimal treatment conditions by analyzing genome-wide screens at multiple rapamycin concentrations. We show that CLIK is an extremely useful tool for evaluating screen quality, determining screen cutoffs, and comparing results between screens. Furthermore, because CLIK uses previously annotated interaction data to determine biologically informed cutoffs, it provides additional insights into screen results, which supplement traditional statistical approaches. PMID:23589890
NASA Astrophysics Data System (ADS)
Hopkins, Julia; Elgar, Steve; Raubenheimer, Britt
2017-04-01
Accurately characterizing the interaction of waves and currents can improve predictions of wave propagation and subsequent sediment transport in the nearshore. Along the southern shoreline of Martha's Vineyard, MA, waves propagate across strong tidal currents as they shoal, providing an ideal environment for investigating wave-current interaction. Wave directions and mean currents observed for two 1-month-long periods in 7- and 2-m water depths along 11 km of the Martha's Vineyard shoreline have strong tidal modulations. Wave directions shift by as much as 70 degrees over a tidal cycle in 7 m depth, and by as much as 25 degrees in 2 m depth. The magnitude of the tidal modulations in the wave field decreases alongshore to the west, consistent with the observed decrease in tidal currents from 2.1 to 0.2 m/s. The observations are reproduced accurately by a numerical model (SWAN and Deflt3D-FLOW) that simulates waves and currents over the observed bathymetry. Model simulations with and without wave-current interaction and tidal depth changes demonstrate that the observed tidal modulations of the wave field primarily are caused by wave-current interaction and not by tidal changes to water depths over the nearby complex shoals. Sediment transport estimates from simulated wave conditions using a range of tidal currents and offshore wave fields indicate that the modulation of the wave field at Martha's Vineyard can impact the direction of wave-induced alongshore sediment transport, sometimes driving transport opposing the direction of the offshore incident wave field. As such, the observations and model simulations suggest the importance of wave-current interaction to tidally averaged transport in mixed-energy wave-and-current nearshore environments. Supported by ASD(R&E), NSF, NOAA (Sea Grant), and ONR.
Dogs Identify Agents in Third-Party Interactions on the Basis of the Observed Degree of Contingency.
Tauzin, Tibor; Kovács, Krisztina; Topál, József
2016-08-01
To investigate whether dogs could recognize contingent reactivity as a marker of agents' interaction, we performed an experiment in which dogs were presented with third-party contingent events. In the perfect-contingency condition, dogs were shown an unfamiliar self-propelled agent (SPA) that performed actions corresponding to audio clips of verbal commands played by a computer. In the high-but-imperfect-contingency condition, the SPA responded to the verbal commands on only two thirds of the trials; in the low-contingency condition, the SPA responded to the commands on only one third of the trials. In the test phase, the SPA approached one of two tennis balls, and then the dog was allowed to choose one of the balls. The proportion of trials on which a dog chose the object indicated by the SPA increased with the degree of contingency: Dogs chose the target object significantly above chance level only in the perfect-contingency condition. This finding suggests that dogs may use the degree of temporal contingency observed in third-party interactions as a cue to identify agents. © The Author(s) 2016.
NASA Technical Reports Server (NTRS)
Nakamura, Teruko
2003-01-01
We have studied the weeping habit of Japanese flowering cherry tree in the field of Tama Forest Science Garden, Forestry and Forest Products Research Institute at the foot of Mt. Takao. Since cherry trees at various age were the materials for our plant physiology experiments, our studies were conducted in the fields where we experienced certain difficulties. Even under such difficult environment that was rather unexpected and uncontrollable, we could obtain fruitful results on the growth of cherry tree, and found them scientifically significant, especially in terms of biological effects of gravity on earth. Moreover, a lot of interesting interactions of cherry trees with various kinds of animals were observed in parallel to the plant physiology.
NASA Astrophysics Data System (ADS)
Luhmann, J. G.; Alvarez, K.; Curry, S.; Dong, C.; Ma, Y.; Bougher, S. W.; Benna, M.; Elrod, M. K.; Mahaffy, P. R.; Withers, P.; Girazian, Z.; Connerney, J. E. P.; Brain, D.; Jakosky, B. M.
2016-12-01
Since the two Viking Landers, progress on improving our global knowledge of the Martian ionosphere's characteristics has been limited by the available instrumentation and sampling geometries. In particular, while remote sensing and the lower energy plasma spectrometer observations on missions including MGS and MEX provided insights on the effects of the crustal magnetic fields of Mars and the solar wind interaction, these measurements did not allow the broader thermal ion surveys necessary to test our current understanding of the region between the exobase at 200 km altitude and the solar wind interaction boundary. In this study we use the MAVEN NGIMS thermal ion mass spectrometer observations from the prime mission year 2015 to construct some statistical pictures of the increasingly collisionless region of the ionosphere between 200 and 500 km where crustal field and solar wind interaction effects should begin to dominate its behavior. Comparisons with models of the solar wind interaction with Mars provide important global context for these observations, including the roles of system diversity associated with changing crustal field and interplanetary field orientations.
ERIC Educational Resources Information Center
Schneider, Barry H.
2009-01-01
Background: The friendships of socially withdrawn/anxious children and early adolescents have been found to lack critical rewarding qualities. Observational research may help elucidate the obstacles they face in forming and maintaining high-quality friendships with sociable peers. Method: We observed the interactions of 38 socially withdrawn early…
THE PICNIC GAME: PRESENTATION OF A SITUATION OF OBSERVATION TO ASSESS FAMILY INTERACTIONS.
Favez, Nicolas; Frascarolo, France; Grimard, Nathalie
2016-05-01
The aim of this article is to present a situation of observation designed for the assessment of family interactions: The PicNic Game (PNG). In this situation, families are invited to play at having a picnic together. This can be done with any number of children, aged from a few weeks to adolescence. A companion assessment tool, the Revised-Picnic Assessment Scale (Re-PAS), allows evaluation of interactions in the family on several dimensions. This article presents the PNG and a preliminary study of the validation of the Re-PAS dimensions in a sample of families (N = 67) with 18-month-old infants and their siblings. The PNG was well-received by the families. Construct validity of the Re-PAS was tested, first against self-reported data by mothers and fathers regarding marital satisfaction, coparenting behavior, and division of household tasks, and then against observed maternal and paternal sensitivity and controlling behaviors assessed during free-play. Results show satisfactory preliminary reliability and validity. Two contrasting cases are presented to illustrate the different interactions highlighted in the PNG. This situation is useful for researchers and clinicians, particularly as a basis for video-feedback work with the family. © 2016 Michigan Association for Infant Mental Health.
NASA Astrophysics Data System (ADS)
Vernisse, Loranne; Guillermet, Olivier; Gourdon, André; Coratger, Roland
2018-03-01
Derivative perylene molecules deposited on Ag(111) and on NaCl(001) ultrathin layers have been investigated using low temperature STM and NC-AFM. When the metallic substrate is held at ambient temperature during evaporation, the molecules form characteristic trimers on the Ag(111) surface and interact through their polar groups. Close to the steps, the molecules form linear structures and seems to stand side by side. On the other hand, after deposition on a substrate cooled at liquid helium temperature, single molecules are observed both on metal and on NaCl. On the ultrathin insulator layers, the STM images present characteristic contrasts related to the molecular orbitals which favors the localization of aldehyde groups. In this case, the lateral molecular interactions may induce the formation of small assemblies in which the electronic levels are slightly shifted. A possible interpretation of this phenomenon is to take into account polar interactions and charge transfer between neighboring molecules.
Rime, Jérôme; Tissot, Hervé; Favez, Nicolas; Watson, Michael; Stadlmayr, Werner
2018-01-01
The quality of family relations, observed during mother-father-infant triadic interactions, has been shown to be an important contributor to child social and affective development, beyond the quality of dyadic mother-child, father-child, and marital relationships. Triadic interactions have been well described in families with 3 month olds and older children using the Lausanne Trilogue Play (LTP). Little is known about the development of mother-father-baby interactions in the very 1st weeks postpartum, mostly because no specific observational setting or particular instrument had been designed to cover this age yet. To fill this gap, we adapted the LTP to create a new observational setting, namely the Diaper Change Play (DCP). Interactions are assessed using the Family Alliance Assessment Scales for DCP (FAAS-DCP). We present the validation of the DCP and its coding system, the FAAS-DCP. The three validation studies presented here (44 mother-father-child-triads) involve a sample of parents with 3-week-old infants recruited in two maternity wards ( n = 32 and n = 12) in Switzerland. Infants from both sites were all healthy according to their APGAR scores, weight at birth, and scores on the NICU Network Neurobehavioral Scale (NNNS), which was additionally conducted on the twelve infants recruited in one of the maternity ward. Results showed that the "FAAS - DCP" coding system has good psychometric properties, with a good internal consistency and a satisfying reliability among the three independent raters. Finally, the "FAAS-DCP" scores on the interactive dimensions are comparable to the similar dimensions in the FAAS-LTP. The results showed that there is no statistically significant difference on scores between the "FAAS-DCP" and the "FAAS," which is consistent with previous studies underlying stability in triadic interaction patterns from pregnancy to 18 months. These first results indicated that the DCP is a promising observational setting, able to assess the
Rime, Jérôme; Tissot, Hervé; Favez, Nicolas; Watson, Michael; Stadlmayr, Werner
2018-01-01
The quality of family relations, observed during mother–father–infant triadic interactions, has been shown to be an important contributor to child social and affective development, beyond the quality of dyadic mother–child, father–child, and marital relationships. Triadic interactions have been well described in families with 3 month olds and older children using the Lausanne Trilogue Play (LTP). Little is known about the development of mother–father–baby interactions in the very 1st weeks postpartum, mostly because no specific observational setting or particular instrument had been designed to cover this age yet. To fill this gap, we adapted the LTP to create a new observational setting, namely the Diaper Change Play (DCP). Interactions are assessed using the Family Alliance Assessment Scales for DCP (FAAS-DCP). We present the validation of the DCP and its coding system, the FAAS-DCP. The three validation studies presented here (44 mother–father–child–triads) involve a sample of parents with 3-week-old infants recruited in two maternity wards (n = 32 and n = 12) in Switzerland. Infants from both sites were all healthy according to their APGAR scores, weight at birth, and scores on the NICU Network Neurobehavioral Scale (NNNS), which was additionally conducted on the twelve infants recruited in one of the maternity ward. Results showed that the “FAAS – DCP” coding system has good psychometric properties, with a good internal consistency and a satisfying reliability among the three independent raters. Finally, the “FAAS-DCP” scores on the interactive dimensions are comparable to the similar dimensions in the FAAS-LTP. The results showed that there is no statistically significant difference on scores between the “FAAS-DCP” and the “FAAS,” which is consistent with previous studies underlying stability in triadic interaction patterns from pregnancy to 18 months. These first results indicated that the DCP is a promising observational
Waller, Rebecca; Shaw, Daniel S.; Hyde, Luke W.
2016-01-01
Background Callous-unemotional behaviors identify children at risk for severe and chronic antisocial behavior. Research is needed to establish pathways from temperament and parenting factors that give rise to callous-unemotional behaviors, including interactions of positive versus harsh parenting with child fearlessness. Methods Multi-method data, including parent reports and observations of parent and child behavior, were drawn from a prospective, longitudinal sample of low-income boys (N=310) with assessments at 18, 24, and 42 months, and at ages 10–12 years old. Results Parent-reported callous-unemotional, oppositional, and attention-deficit factors were separable at 42 months. Callous-unemotional behaviors at 42 months predicted callous-unemotional behaviors at ages 10–12, accounting for earlier oppositional and attention-deficit behaviors and self-reported child delinquency at ages 10–12. Observations of fearlessness at 24 months predicted callous-unemotional behaviors at 42 months, but only when parents exhibited low observed levels of positive parenting. The interaction of fearlessness and low positive parenting indirectly predicted callous-unemotional behaviors at 10–12 via callous-unemotional behaviors at 42 months. Conclusions Early fearlessness interacts with low positive parenting to predict early callous-unemotional behaviors, with lasting effects of this person-by-context interaction on callous-unemotional behaviors into late-childhood. PMID:27917472
ERIC Educational Resources Information Center
Gray, Sarah A. O.; Carter, Alice S.; Briggs-Gowan, Margaret J.; Hill, Carri; Danis, Barbara; Keenan, Kate; Wakschlag, Lauren S.
2012-01-01
Sex differences in disruptive behavior and sensitivity to social context are documented, but the intersection between them is rarely examined empirically. This report focuses on sex differences in observed disruptive behavior across interactional contexts and diagnostic status. Preschoolers (n = 327) were classified as nondisruptive (51%),…
ERIC Educational Resources Information Center
Ellis, Wendy E.; Dumas, Tara M.; Mahdy, Jasmine C.; Wolfe, David A.
2012-01-01
Observations of adolescent (n = 258; M age = 15.45) peer group triads (n = 86) were analyzed to identify conversation and interaction styles as a function of within-group and between-group centrality status. Group members' discussions about hypothetical dilemmas were coded for agreements, disagreements, commands, and opinions. Interactions during…
Cham, Heining; West, Stephen G.; Ma, Yue; Aiken, Leona S.
2012-01-01
A Monte Carlo simulation was conducted to investigate the robustness of four latent variable interaction modeling approaches (Constrained Product Indicator [CPI], Generalized Appended Product Indicator [GAPI], Unconstrained Product Indicator [UPI], and Latent Moderated Structural Equations [LMS]) under high degrees of non-normality of the observed exogenous variables. Results showed that the CPI and LMS approaches yielded biased estimates of the interaction effect when the exogenous variables were highly non-normal. When the violation of non-normality was not severe (normal; symmetric with excess kurtosis < 1), the LMS approach yielded the most efficient estimates of the latent interaction effect with the highest statistical power. In highly non-normal conditions, the GAPI and UPI approaches with ML estimation yielded unbiased latent interaction effect estimates, with acceptable actual Type-I error rates for both the Wald and likelihood ratio tests of interaction effect at N ≥ 500. An empirical example illustrated the use of the four approaches in testing a latent variable interaction between academic self-efficacy and positive family role models in the prediction of academic performance. PMID:23457417
Chirally selective, intramolecular interaction observed in an aminoacyl adenylate anhydride
NASA Technical Reports Server (NTRS)
Lacey, J. C., Jr.; Hall, L. M.; Mullins, D. W., Jr.; Watkins, C. L.
1985-01-01
The interaction between amino acids and nucleotide bases is studied. The proton NMR spectrum of N-acetylphenylalanyl-AMP-anhydride is analyzed H8 and H2 signals, two upfield signals of equal size, and five phenylalanine ring proton signals are observed in the spectrum; the upfield movement of the proton and the racemization of the N-acetyl L-phenylalanine material are examined. The differences in the position of the signals due to the diastereoisomers are investigated. The separation of the D and L amino acyl adenylates using HPLC is described. H-1 NMR spectra of the isomers are examined in order to determine which isomer displays the strongest interaction between the phenyl ring and the adenine ring. The spectra reveal that the L isomer shows the highest upfield change of both H8 and H2 signals. It is noted that the phenyl ring lies over C2 of the adenine ring with the phenyl meta and para protons extended past the adenine ring and the phenyl ortho protons.
ERIC Educational Resources Information Center
Rockhill, Carol M.; Fan, Ming-Yu; Katon, Wayne J.; McCauley, Elizabeth; Crick, Nicki R.; Pleck, Joseph H.
2007-01-01
This observational study supplements the strong and consistent link found between childhood depression and deficits in interpersonal functioning by examining the relationship between a high versus low score on the Children's Depression Inventory (CDI) and children's emotions when interacting with their best friends. High-CDI and low-CDI target…
Spillane, S M; Pati, G S; Salit, K; Hall, M; Kumar, P; Beausoleil, R G; Shahriar, M S
2008-06-13
We report the observation of low-light level optical interactions in a tapered optical nanofiber (TNF) embedded in a hot rubidium vapor. The small optical mode area plays a significant role in the optical properties of the hot vapor Rb-TNF system, allowing nonlinear optical interactions with nW level powers even in the presence of transit-time dephasing rates much larger than the intrinsic linewidth. We demonstrate nonlinear absorption and V-type electromagnetically induced transparency with cw powers below 10 nW, comparable to the best results in any Rb-optical waveguide system. The good performance and flexibility of the Rb-TNF system makes it a very promising candidate for ultralow power resonant nonlinear optical applications.
Adler, Peter B; Kleinhesselink, Andrew; Giles, Hooker; Taylor, J Bret; Teller, Brittany; Ellner, Stephen P
2018-04-28
Stable coexistence requires intraspecific limitations to be stronger than interspecific limitations. The greater the difference between intra- and interspecific limitations, the more stable the coexistence, and the weaker the competitive release any species should experience following removal of competitors. We conducted a removal experiment to test whether a previously estimated model, showing surprisingly weak interspecific competition for four dominant species in a sagebrush steppe, accurately predicts competitive release. Our treatments were 1) removal of all perennial grasses and 2) removal of the dominant shrub, Artemisia tripartita. We regressed survival, growth and recruitment on the locations, sizes, and species identities of neighboring plants, along with an indicator variable for removal treatment. If our "baseline" regression model, which accounts for local plant-plant interactions, accurately explains the observed responses to removals, then the removal coefficient should be non-significant. For survival, the removal coefficients were never significantly different from zero, and only A. tripartita showed a (negative) response to removals at the recruitment stage. For growth, the removal treatment effect was significant and positive for two species, Poa secunda and Pseudoroegneria spicata, indicating that the baseline model underestimated interspecific competition. For all three grass species, population models based on the vital rate regressions that included removal effects projected 1.4 to 3-fold increases in equilibrium population size relative to the baseline model (no removal effects). However, we found no evidence of higher response to removal in quadrats with higher pretreatment cover of A. tripartita, or by plants experiencing higher pre-treatment crowding by A. tripartita, raising questions about the mechanisms driving the positive response to removal. While our results show the value of combining observations with a simple removal experiment
Observation of the Borromean Three-Body Förster Resonances for Three Interacting Rb Rydberg Atoms.
Tretyakov, D B; Beterov, I I; Yakshina, E A; Entin, V M; Ryabtsev, I I; Cheinet, P; Pillet, P
2017-10-27
Three-body Förster resonances at long-range interactions of Rydberg atoms were first predicted and observed in Cs Rydberg atoms by Faoro et al. [Nat. Commun. 6, 8173 (2015)NCAOBW2041-172310.1038/ncomms9173]. In these resonances, one of the atoms carries away an energy excess preventing the two-body resonance, leading thus to a Borromean type of Förster energy transfer. But they were in fact observed as the average signal for the large number of atoms N≫1. In this Letter, we report on the first experimental observation of the three-body Förster resonances 3×nP_{3/2}(|M|)→nS_{1/2}+(n+1)S_{1/2}+nP_{3/2}(|M^{*}|) in a few Rb Rydberg atoms with n=36, 37. We have found here clear evidence that there is no signature of the three-body Förster resonance for exactly two interacting Rydberg atoms, while it is present for N=3-5 atoms. This demonstrates the assumption that three-body resonances can generalize to any Rydberg atom. As such resonance represents an effective three-body operator, it can be used to directly control the three-body interactions in quantum simulations and quantum information processing with Rydberg atoms.
Observation of the Borromean Three-Body Förster Resonances for Three Interacting Rb Rydberg Atoms
NASA Astrophysics Data System (ADS)
Tretyakov, D. B.; Beterov, I. I.; Yakshina, E. A.; Entin, V. M.; Ryabtsev, I. I.; Cheinet, P.; Pillet, P.
2017-10-01
Three-body Förster resonances at long-range interactions of Rydberg atoms were first predicted and observed in Cs Rydberg atoms by Faoro et al. [Nat. Commun. 6, 8173 (2015), 10.1038/ncomms9173]. In these resonances, one of the atoms carries away an energy excess preventing the two-body resonance, leading thus to a Borromean type of Förster energy transfer. But they were in fact observed as the average signal for the large number of atoms N ≫1 . In this Letter, we report on the first experimental observation of the three-body Förster resonances 3 ×n P3 /2(|M |)→n S1 /2+(n +1 )S1 /2+n P3 /2(|M*|) in a few Rb Rydberg atoms with n =36 , 37. We have found here clear evidence that there is no signature of the three-body Förster resonance for exactly two interacting Rydberg atoms, while it is present for N =3 - 5 atoms. This demonstrates the assumption that three-body resonances can generalize to any Rydberg atom. As such resonance represents an effective three-body operator, it can be used to directly control the three-body interactions in quantum simulations and quantum information processing with Rydberg atoms.
NASA Astrophysics Data System (ADS)
Halekas, J. S.; Poppe, A. R.; Lue, C.; Farrell, W. M.; McFadden, J. P.
2017-06-01
A statistical investigation of 5 years of observations from the two-probe Acceleration, Reconnection, Turbulence, and Electrodynamics of Moon's Interaction with the Sun (ARTEMIS) mission reveals that strong compressional interactions occur infrequently at high altitudes near the ecliptic but can form in a wide range of solar wind conditions and can occur up to two lunar radii downstream from the lunar limb. The compressional events, some of which may represent small-scale collisionless shocks ("limb shocks"), occur in both steady and variable interplanetary magnetic field (IMF) conditions, with those forming in steady IMF well organized by the location of lunar remanent crustal magnetization. The events observed by ARTEMIS have similarities to ion foreshock phenomena, and those observed in variable IMF conditions may result from either local lunar interactions or distant terrestrial foreshock interactions. Observed velocity deflections associated with compressional events are always outward from the lunar wake, regardless of location and solar wind conditions. However, events for which the observed velocity deflection is parallel to the upstream motional electric field form in distinctly different solar wind conditions and locations than events with antiparallel deflections. Consideration of the momentum transfer between incoming and reflected solar wind populations helps explain the observed characteristics of the different groups of events.
FUSE Observations of the Active Interacting Binary RY Persei
NASA Astrophysics Data System (ADS)
Peters, G. J.; Polidan, R. S.
2003-12-01
RY Per (HD 17034, B4 V + F7 II-III, P=6.86 d) is a massive interacting binary (6.25 M⊙ + 1.60 M⊙, Olson & Plavec 1997, AJ, 113, 425) that displays a variable weak accretion disk that emits in Hα (Barai, et al., preprint). FUSE observations of this system, carried through in 2002 October at phases 0.20, 0.57, and 0.97 and during its total eclipse on 2002 December 8 are presented. The totality data were binned into two phase intervals: 0.0056-0.9976 (after second contact) and 0.0052-0.0089 (just before third contact). Both eclipse observations reveal broad, prominent emission lines of N III (UV1, λ λ 990-992 Å), O VI (UV1, λ λ 1032,1038 Å), N II (UV1, λ λ 1084-1086 Å), Si III (UV5, λ λ 1108,1109,1113 Å), Si IV(UV3, λ λ 1122,1138 Å), and Fe III (UV1, λ λ 1122-32 Å). Emission from C III (UV4, λ 1176 Å) seen during totality in FUSE observations of the Algol binaries V356 Sgr and TT Hya is conspicuously absent. C III (UV1, λ 977 Å) is also absent. This observation combined with the strong presence of N II, III emission suggests that material processed through the CNO cycle in the mass loser is now being transferred to the B star. The FUSE data imply that the emitting plasma is hot ( ˜100,000-300,000 K) and located above/below the orbital plane. The source of this apparent bipolar flow (also seen in V356 Sgr and TT Hya) may be the splash region detected near phase 0.5 in IUE observations of the N V resonance line, but absorption features from this region were not seen in the non-eclipse FUSE observations. A model for the circumstellar material in this system will be presented and the FUSE observations will be compared with those of V356 Sgr and TT Hya. GJP is grateful for support from NASA Grant NAG5-12253.
Observations of energetic particles between a pair of corotating interaction regions
DOE Office of Scientific and Technical Information (OSTI.GOV)
Wu, Z.; Chen, Y.; Tang, C. L.
We report observations of the acceleration and trapping of energetic ions and electrons between a pair of corotating interaction regions (CIRs). The event occurred in Carrington Rotation 2060. Observed by the STEREO-B spacecraft, the two CIRs were separated by less than 5 days. In contrast to other CIR events, the fluxes of the energetic ions and electrons in this event reached their maxima between the trailing edge of the first CIR and the leading edge of the second CIR. The radial magnetic field (B{sub r} ) reversed its sense and the anisotropy of the flux also changed from Sunward tomore » anti-Sunward between the two CIRs. Furthermore, there was an extended period of counterstreaming suprathermal electrons between the two CIRs. Similar observations for this event were also obtained with the Advanced Composition Explorer and STEREO-A. We conjecture that these observations were due to a U-shaped, large-scale magnetic field topology connecting the reverse shock of the first CIR and the forward shock of the second CIR. Such a disconnected U-shaped magnetic field topology may have formed due to magnetic reconnection in the upper corona.« less
Waller, Rebecca; Shaw, Daniel S; Hyde, Luke W
2017-03-01
Callous-unemotional behaviors identify children at risk for severe and chronic antisocial behavior. Research is needed to establish pathways from temperament and parenting factors that give rise to callous-unemotional behaviors, including interactions of positive versus harsh parenting with child fearlessness. Multimethod data, including parent reports and observations of parent and child behavior, were drawn from a prospective, longitudinal sample of low-income boys (N = 310) with assessments at 18, 24, and 42 months, and at ages 10-12 years old. Parent-reported callous-unemotional, oppositional, and attention-deficit factors were separable at 42 months. Callous-unemotional behaviors at 42 months predicted callous-unemotional behaviors at ages 10-12, accounting for earlier oppositional and attention-deficit behaviors and self-reported child delinquency at ages 10-12. Observations of fearlessness at 24 months predicted callous-unemotional behaviors at 42 months, but only when parents exhibited low observed levels of positive parenting. The interaction of fearlessness and low positive parenting indirectly predicted callous-unemotional behaviors at 10-12 via callous-unemotional behaviors at 42 months. Early fearlessness interacts with low positive parenting to predict early callous-unemotional behaviors, with lasting effects of this person-by-context interaction on callous-unemotional behaviors into late childhood. © 2016 Association for Child and Adolescent Mental Health.
Observation of a hierarchy of modes in an interacting one-dimensional system
NASA Astrophysics Data System (ADS)
Ford, Christopher; Moreno, Maria; Jin, Yiqing; Tan, Wooi Kiat; Griffiths, Jon; Farrer, Ian; Jones, Geb; Anthore, Anne; Ritchie, David; Tsyplyatyev, Oleksandr; Schofield, Andrew
2015-03-01
Studying interacting fermions in 1D at high energy, we find a hierarchy in the spectral weights of the excitations theoretically and we observe evidence for second-level excitations experimentally. Diagonalising a model of fermions (without spin), we show that levels of the hierarchy are separated by powers of 2 /L2 , where is a length-scale related to interactions and L is the system length. The first-level (strongest) excitations form a mode with parabolic dispersion, like that of a renormalised single particle. The second-level excitations produce a singular power-law line shape to the first-level mode and multiple power-laws at the spectral edge. We measure momentum-resolved tunneling of electrons (fermions with spin) from/to a wire formed within a GaAs heterostructure, which shows parabolic dispersion of the first-level mode and well-resolved spin-charge separation at low energy with appreciable interaction strength. We find structure resembling the second-level excitations, which dies away quite rapidly at high momentum.
Chiaburu, Dan S; Harris, T Brad; Smith, Troy A
2014-01-01
We integrate system justification and social role theory to explain how observers' system justification and target employees' gender interact to predict observers' expectations of targets' sportsmanship citizenship behaviors. In contrast with social role theory predictions, observers did not expect greater levels of sportsmanship from women compared to men. Yet observers expected more sportsmanship from women (a) when observers were ideologically motivated by gender-specific beliefs (gender-specific system justification; Study 1) and (b) when system justification was cued experimentally (Study 2). A heretofore-unexamined aspect, observers' ideology, modifies their expectations of sportsmanship citizenship across target genders. This has implications for system justification, social role, and organizational citizenship theoretical perspectives.
NASA Technical Reports Server (NTRS)
Cordova, F. A.
1993-01-01
MultiWaveLink is an interactive, computerized data base that was developed to facilitate a multi-wavelength approach to studying astrophysical sources. It can be used to access information about multiwavelenth resources (observers, telescopes, data bases and analysis facilities) or to organize observing campaigns that require either many telescopes operating in different spectral regimes or a network of similar telescopes circumspanning the Earth.
Butcher, Jennifer L; Nasr, Samya Z
2015-01-01
Use a standardized system to code parent-child interactions during respiratory treatments for cystic fibrosis (CF) and analyze relations between behaviors during treatments and medical regimen adherence. A total of 15 families (53% girls; M age = 8.9 years; SD = 1.8) had three respiratory treatments recorded in the home environment and coded. Families provided six 24-hr recalls of child medical regimen activities, and electronic airway clearance time was recorded over 3 months to measure medical regimen adherence. Parent positive attention, instructions, and avoidance of negative statements were significantly related to child cooperation during respiratory treatments. Parental presence, positive attention, instructions, and child cooperation during treatments were related to higher respiratory adherence rates. Direct observation methodology has led to effective nutritional adherence intervention for children with CF. These preliminary data demonstrate that an observational method could also be used to develop interventions to promote respiratory medication adherence. © The Author 2014. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
ERIC Educational Resources Information Center
Foster, Tanina S.
2014-01-01
Introduction: Observational research using the thin slice technique has been routinely incorporated in observational research methods, however there is limited evidence supporting use of this technique compared to full interaction coding. The purpose of this study was to determine if this technique could be reliability coded, if ratings are…
NASA Astrophysics Data System (ADS)
Miceli, M.; Bamba, A.; Orlando, S.; Zhou, P.; Safi-Harb, S.; Chen, Y.; Bocchino, F.
2017-03-01
Context. The Galactic supernova remnant Kes 78 is surrounded by dense molecular clouds, whose projected position overlaps with the extended HESS γ-ray source HESS J1852-000. The X-ray emission from the remnant has recently been revealed by Suzaku observations, which have shown indications for a hard X-ray component in the spectra that might be associated with synchrotron radiation. Aims: We describe the spatial distribution of the physical properties of the X-ray emitting plasma and reveal the effects of the interaction of the remnant with the inhomogeneous ambient medium. We also investigate the origin of the γ-ray emission, which may be inverse-Compton radiation associated with X-ray synchrotron-emitting electrons or hadronic emission originating from the impact of high-energy protons on the nearby clouds. Methods: We analyzed an XMM-Newton EPIC observation of Kes 78 by performing image analysis and spatially resolved spectral analysis on a set of three regions. We tested our findings against the observations of the 12CO and 13CO emission in the environment of the remnant. Results: We reveal the complex X-ray morphology of Kes 78 and find variations in the spectral properties of the plasma, with significantly denser and cooler material at the eastern edge of the remnant, which we interpret as a signature of interaction with a molecular cloud. We also exclude that narrow filaments emit the X-ray synchrotron radiation. Conclusions: Assuming that the very high energy γ-ray emission is associated with Kes 78, the lack of synchrotron emission rules out a leptonic origin. A hadronic origin is further supported by evidence of interaction of the remnant with a dense molecular cloud in its eastern limb.
Lindblad, A; Fink, R F; Bergersen, H; Lundwall, M; Rander, T; Feifel, R; Ohrwall, G; Tchaplyguine, M; Hergenhahn, U; Svensson, S; Björneholm, O
2005-12-01
The surface and bulk components of the x-ray photoelectron spectra of free noble gas clusters are shown to display differences in the influence of postcollision interaction between the photoelectron and the Auger electron on the spectral line shape; the bulk component is observed to be less affected than the surface and atomic parts of the spectra. A model for postcollision interaction in nonmetallic solids and clusters is also provided which takes the polarization screening into account. Core-level photoelectron spectra of Ar, Kr, and Xe have been recorded to verify the dependence of the postcollision interaction effect on the polarizability of the sample.
ERIC Educational Resources Information Center
Humphrey, Laura Lynn
1989-01-01
Compared observations of family interactions among anorexic, bulimic-anorexic, bulimic, and normal families (N=74 families) consisting of father, mother, and teenage daughter. Benjamin's structural analysis of social behavior methodology differentiated clinical from normal families. Found unique patterns among subtypes of eating disorders which…
Case, Laura K; Pineda, Jaime; Ramachandran, Vilayanur S
2015-01-01
Motor imagery and perception- considered generally as forms of motor simulation- share overlapping neural representations with motor production. While much research has focused on the extent of this “common coding,” less attention has been paid to how these overlapping representations interact. How do imagined, observed, or produced actions influence one another, and how do we maintain control over our perception and behavior? In the first part of this review we describe interactions between motor production and motor simulation, and explore apparent regulatory mechanisms that balance these processes. Next, we consider the somatosensory system. Numerous studies now support a “sensory mirror system” comprised of neural representations activated by either afferent sensation or vicarious sensation. In the second part of this review we summarize evidence for shared representations of sensation and sensory simulation (including imagery and observed sensation), and suggest that similar interactions and regulation of simulation occur in the somatosensory domain as in the motor domain. We suggest that both motor and somatosensory simulations are flexibly regulated to support simulations congruent with our sensorimotor experience and goals and suppress or separate the influence of those that are not. These regulatory mechanisms are frequently revealed by cases of brain injury but can also be employed to facilitate sensorimotor rehabilitation. PMID:25863237
Its Preferential Interactions with Biopolymers Account for Diverse Observed Effects of Trehalose
Hong, Jiang; Gierasch, Lila M.; Liu, Zhicheng
2015-01-01
Biopolymer homeostasis underlies the health of organisms, and protective osmolytes have emerged as one strategy used by Nature to preserve biopolymer homeostasis. However, a great deal remains unknown about the mechanism of action of osmolytes. Trehalose, as a prominent example, stabilizes proteins against denaturation by extreme temperature and denaturants, preserves membrane integrity upon freezing or in dry conditions, inhibits polyQ-mediated protein aggregation, and suppresses the aggregation of denatured proteins. The underlying thermodynamic mechanisms of such diverse effects of trehalose remain unclear or controversial. In this study, we applied the surface-additive method developed in the Record laboratory to attack this issue. We characterized the key features of trehalose-biopolymer preferential interactions and found that trehalose has strong unfavorable interactions with aliphatic carbon and significant favorable interactions with amide/anionic oxygen. This dissection has allowed us to elucidate the diverse effects of trehalose and to identify the crucial functional group(s) responsible for its effects. With (semi)quantitative thermodynamic analysis, we discovered that 1) the unfavorable interaction of trehalose with hydrophobic surfaces is the dominant factor in its effect on protein stability, 2) the favorable interaction of trehalose with polar amides enables it to inhibit polyQ-mediated protein aggregation and the aggregation of denatured protein in general, and 3) the favorable interaction of trehalose with phosphate oxygens, together with its unfavorable interaction with aliphatic carbons, enables trehalose to preserve membrane integrity in aqueous solution. These results provide a basis for a full understanding of the role of trehalose in biopolymer homeostasis and the reason behind its evolutionary selection as an osmolyte, as well as for a better application of trehalose as a chemical chaperone. PMID:26153711
Emphasizing the Significance of Electrostatic Interactions in Chemical Bonding
ERIC Educational Resources Information Center
Venkataraman, Bhawani
2017-01-01
This paper describes a pedagogical approach to help students understand chemical bonding by emphasizing the importance of electrostatic interactions between atoms. The approach draws on prior studies that have indicated many misconceptions among students in understanding the nature of the chemical bond and energetics associated with bond formation…
Roveri, O A; Braslavsky, S E
2012-06-01
We have previously reported that bovine serum albumin (BSA) and other proteins that do not contain prosthetic groups exhibited a weak light absorption in the visible, only detectable by pulsed laser-induced optoacoustic spectroscopy (LIOAS). Human serum albumin (HSA) exhibited signals 25% higher than those observed with BSA. Signals comparable to those obtained with BSA were observed with poly(L-Trp, L-Lys), poly(L-Trp, L-Arg) or poly(L-Trp, L-Orn) at pH 7.0. No signals were obtained when tryptophan was replaced by other amino acids or when free tryptophan or the tripeptide Lys-Trp-Lys was assayed (pH 7.0). Tryptophan in HCl 5 N produced LIOAS signals similar to those produced by tryptophan-containing copolymers. Moreover, the absorption peak could be observed in a UV-VIS spectrophotometer. Therefore, the LIOAS signals obtained with BSA, HSA, and tryptophan-containing random copolymers may be attributed to a new transition of the indole moiety of their tryptophan residues when "protonated". Tryptophan residues of proteins are known to participate in π-cation interactions, which are important in protein stability and function. As a matter of fact, HSA and BSA contain an internal tryptophan in close proximity to lysine and arginine residues and therefore suitable for π-cation interactions. The strength of this type of interaction strongly depends on distances and relative orientations of both amino acid residues. Accordingly, these interactions should be highly sensitive to conformational changes. Based on preliminary results that have shown that LIOAS signal at 532 nm depended on the aggregation state of BSA and/or on the oxidation state of its Cys-34, we postulate that the LIOAS signal observed with proteins and tryptophan-containing polypeptides are related to Trp-Lys or Trp-Arg interactions and that the intensity of the signal depends on the strength of such interactions.
Cheng, Ting-Yuan David; Makar, Karen W; Neuhouser, Marian L; Miller, Joshua W; Song, Xiaoling; Brown, Elissa C; Beresford, Shirley A A; Zheng, Yingye; Poole, Elizabeth M; Galbraith, Rachel L; Duggan, David J; Habermann, Nina; Bailey, Lynn B; Maneval, David R; Caudill, Marie A; Toriola, Adetunji T; Green, Ralph; Ulrich, Cornelia M
2015-10-15
Investigations of folate-mediated one-carbon metabolism (FOCM) genes and gene-nutrient interactions with respect to colorectal cancer (CRC) risk are limited to candidate polymorphisms and dietary folate. This study comprehensively investigated associations between genetic variants in FOCM and CRC risk and whether the FOCM nutrient status modified these associations. Two hundred eighty-eight candidate and tagging single-nucleotide polymorphisms (SNPs) in 30 FOCM genes were genotyped for 821 incident CRC case-control matched pairs in the Women's Health Initiative Observational Study cohort. FOCM biomarkers (red blood cell [RBC] folate, plasma folate, pyridoxal-5'-phosphate [PLP], vitamin B12, and homocysteine) and self-reported alcohol consumption were measured at the baseline. Conditional logistic regression was implemented; effect modification was examined on the basis of known enzyme-nutrient relations. Statistically significant associations were observed between CRC risk and functionally defined candidate SNPs of methylenetetrahydrofolate dehydrogenase 1 (MTHFD1; K134R), 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR; P450R), and PR domain containing 2 with ZNF domain (PRDM2; S450N) and a literature candidate SNP of thymidylate synthase (TYMS; g.676789A>T; nominal P < .05). In addition, suggestive associations were noted for tagging SNPs in cystathionine-β-synthase (CBS), dihydrofolate reductase (DHFR), DNA (cytosine-5-)-methyltransferase 3β (DNMT3B), methionine adenosyltransferase I α (MAT1A), MTHFD1, and MTRR (nominal P < .05; adjusted P, not significant). Significant interactions between nutrient biomarkers and candidate polymorphisms were observed for 1) plasma/RBC folate and folate hydrolase 1 (FOLH1), paraoxonase 1 (PON1), transcobalamin II (TCN2), DNMT1, and DNMT3B; 2) plasma PLP and TYMS TS3; 3) plasma B12 and betaine-homocysteine S-methyltransferase 2 (BHMT2); and 4) homocysteine and methylenetetrahydrofolate reductase
Craig B. Clements; Neil P. Lareau; Daisuke Seto; Jonathan Contezac; Braniff Davis; Casey Teske; Thomas J. Zajkowski; Andrew T. Hudak; Benjamin C. Bright; Matthew B. Dickinson; Bret W. Butler; Daniel Jimenez; J. Kevin Hiers
2016-01-01
The role of fire-atmosphere coupling on fire behaviour is not well established, and to date few field observations have been made to investigate the interactions between fire spread and fire-induced winds. Therefore, comprehensive field observations are needed to better understand micrometeorological aspects of fire spread. To address this need, meteorological...
ERIC Educational Resources Information Center
Hsiao, Yu-Yu; Kwok, Oi-Man; Lai, Mark H. C.
2018-01-01
Path models with observed composites based on multiple items (e.g., mean or sum score of the items) are commonly used to test interaction effects. Under this practice, researchers generally assume that the observed composites are measured without errors. In this study, we reviewed and evaluated two alternative methods within the structural…
Lessard, Benoît H; Lough, Alan J; Bender, Timothy P
2016-07-01
We report the syntheses and characterization of three solution-processable phen-oxy silicon phthalocyanines (SiPcs), namely bis-(3-methyl-phen-oxy)(phthalocyanine)silicon [(3MP)2-SiPc], C46H30N8O2Si, bis-(2-sec-butyl-phen-oxy)(phthalocyanine)silicon [(2secBP)2-SiPc], C44H24I2N8O2Si, and bis-(3-iodo-phen-oxy)(phthalocyanine)silicon [(3IP)2-SiPc], C52H42N8O2Si. Crystals grown of these compounds were characterized by single-crystal X-ray diffraction and the π-π inter-actions between the aromatic SiPc cores were studied. It was determined that (3MP)2-SiPc has similar inter-actions to previously reported bis-(3,4,5-tri-fluoro-phen-oxy)silicon phthalocyanines [(345 F)2-SiPc] with significant π-π inter-actions between the SiPc groups. (3IP)2-SiPc and (2secBP)2-SiPc both experienced a parallel stacking of two of the peripheral aromatic groups. In all three cases, the solubility of these mol-ecules was increased by the addition of phen-oxy groups while maintaining π-π inter-actions between the aromatic SiPc groups. The solubility of (2secBP)2-SiPc was significantly higher than other bis-phen-oxy-SiPcs and this was exemplified by the higher observed disorder within the crystal structure.
Tan, Sin-Ying; Ata, Seher; Wanless, Erica J
2013-07-18
The interactions between two individual particle-stabilized bubbles were investigated, in the absence of surfactant, using a combination of coalescence rig and high-speed video camera. This combination allows the visualization of bubble coalescence dynamics which provide information on bubble stability. Experimental data suggested that bubble stability is enhanced by both the adsorption of particles at the interface as indicated by the long induction time and the increase in damping coefficient at high surface coverage. The interaction between an armored bubble and a bare bubble (asymmetric interaction) can be destabilized through the addition of a small amount of salt, which suggested that electrostatic interactions play a significant role in bubble stability. Interestingly, the DLVO theory cannot be used to describe the bubble stability in the case of a symmetric interaction as coalescence was inhibited at 0.1 M KCl in both the absence and presence of particles at the interfaces. Furthermore, bubbles can also be destabilized by increasing the particle hydrophobicity. This behavior is due to thinner liquid films between bubbles and an increase in film drainage rate. The fraction of particles detached from the bubble surface after film rupture was found to be very similar within the range of solution ionic strength, surface coverage, and particle hydrophobicity studied. This lack of dependence implies that the kinetic energy generated by the coalescing bubbles is larger than the attachment energy of the particles and dominates the detachment process. This study illuminates the stability behavior of individual particle-stabilized bubbles and has potential impact on processes which involve their interaction.
Taninaka, Atsushi; Yoshida, Shoji; Kanazawa, Ken; Hayaki, Eiko; Takeuchi, Osamu; Shigekawa, Hidemi
2016-06-16
Scanning tunneling microscopy/spectroscopy (STM/STS) was carried out to investigate the structures of Mn atoms deposited on a GaAs(110) surface at room temperature to directly observe the characteristics of interactions between Mn atoms in GaAs. Mn atoms were paired with a probability higher than the random distribution, indicating an attractive interaction between them. In fact, re-pairing of unpaired Mn atoms was observed during STS measurement. The pair initially had a new structure, which was transformed during STS measurement into one of those formed by atom manipulation at 4 K. Mn atoms in pairs and trimers were aligned in the <110> direction, which is theoretically predicted to produce a high Curie temperature.
NASA Astrophysics Data System (ADS)
Lagoudakis, K. G.; Fischer, K. A.; Sarmiento, T.; McMahon, P. L.; Radulaski, M.; Zhang, J. L.; Kelaita, Y.; Dory, C.; Müller, K.; Vučković, J.
2017-01-01
Although individual spins in quantum dots have been studied extensively as qubits, their investigation under strong resonant driving in the scope of accessing Mollow physics is still an open question. Here, we have grown high quality positively charged quantum dots embedded in a planar microcavity that enable enhanced light-matter interactions. Under a strong magnetic field in the Voigt configuration, individual positively charged quantum dots provide a double lambda level structure. Using a combination of above-band and resonant excitation, we observe the formation of Mollow triplets on all optical transitions. We find that when the strong resonant drive power is used to tune the Mollow-triplet lines through each other, we observe anticrossings. We also demonstrate that the interaction that gives rise to the anticrossings can be controlled in strength by tuning the polarization of the resonant laser drive. Quantum-optical modeling of our system fully captures the experimentally observed spectra and provides insight on the complicated level structure that results from the strong driving of the double lambda system.
ERIC Educational Resources Information Center
Restorff, Diane E.; Abery, Brian H.
2013-01-01
As part of the validation process for alternate assessments, 39 classroom observations were conducted to gather data about current practices in providing academic instruction to students with significant intellectual disability. Using a standardized protocol, data were gathered using direct instructional observation, an Individualized Education…
Observational constraints on secret neutrino interactions from big bang nucleosynthesis
NASA Astrophysics Data System (ADS)
Huang, Guo-yuan; Ohlsson, Tommy; Zhou, Shun
2018-04-01
We investigate possible interactions between neutrinos and massive scalar bosons via gϕν ¯ν ϕ (or massive vector bosons via gVν ¯γμν Vμ) and explore the allowed parameter space of the coupling constant gϕ (or gV) and the scalar (or vector) boson mass mϕ (or mV) by requiring that these secret neutrino interactions (SNIs) should not spoil the success of big bang nucleosynthesis (BBN). Incorporating the SNIs into the evolution of the early Universe in the BBN era, we numerically solve the Boltzmann equations and compare the predictions for the abundances of light elements with observations. It turns out that the constraint on gϕ and mϕ in the scalar-boson case is rather weak, due to a small number of degrees of freedom (d.o.f.). However, in the vector-boson case, the most stringent bound on the coupling gV≲6 ×10-10 at 95% confidence level is obtained for mV≃1 MeV , while the bound becomes much weaker gV≲8 ×10-6 for smaller masses mV≲10-4 MeV . Moreover, we discuss in some detail how the SNIs affect the cosmological evolution and the abundances of the lightest elements.
Coding Manual for Continuous Observation of Interactions by Single Subjects in an Academic Setting.
ERIC Educational Resources Information Center
Cobb, Joseph A.; Hops, Hyman
The manual, designed particularly for work with acting-out or behavior problem students, describes coding procedures used in the observation of continuous classroom interactions between the student and his peers and teacher. Peer and/or teacher behaviors antecedent and consequent to the subject's behavior are identified in the coding process,…
NASA Astrophysics Data System (ADS)
Song, Xia; Hoffman, Forrest M.; Iversen, Colleen M.; Yin, Yunhe; Kumar, Jitendra; Ma, Chun; Xu, Xiaofeng
2017-09-01
Earth system models (ESMs) have been widely used for projecting global vegetation carbon dynamics, yet how well ESMs performed for simulating vegetation carbon density remains untested. We compiled observational data of vegetation carbon density from literature and existing data sets to evaluate nine ESMs at site, biome, latitude, and global scales. Three variables—root (including fine and coarse roots), total vegetation carbon density, and the root:total vegetation carbon ratios (R/T ratios), were chosen for ESM evaluation. ESM models performed well in simulating the spatial distribution of carbon densities in root (
NASA Astrophysics Data System (ADS)
Lagoudakis, K. G.; Fischer, K. A.; Sarmiento, T.; McMahon, P. L.; Radulaski, M.; Zhang, J. L.; Kelaita, Y.; Dory, C.; Mueller, K. M.; Vuckovic, J.
Although individual spins in quantum dots have been extensively used as qubits, their investigation under strong resonant driving in view of accessing Mollow physics is still an open question. We have grown high quality positively charged quantum dots (QD) embedded in a planar microcavity that enable enhanced light matter interactions. Applying a strong magnetic field in the Voigt configuration, individual positively charged quantum dots provide a double lambda level structure. Using a combination of above band and resonant excitation, we observe the formation of Mollow triplets. We investigate the regime where the Mollow sideband splittings are equal to the Zeeman splitting; we observe strong interactions between the Mollow sidebands of the inner transitions and the outer transitions in the form of very clear anticrossings. We investigated these anticrossings and we were able to modify the observed anticrossing splittings on demand by rotating the polarization of the resonant laser. We also developed a quantum-optical model of our system that fully captures the experimentally observed spectra and provides insight on the complicated level structure that results from the strong driving of our positively charged quantum dot. The authors acknowledge financial support from the Army Research Office (Grant No. W911NF1310309) and support from the National Science Foundation, Division of Materials Research (Grant No. 1503759).
VIGOR: Virtual Interaction with Gravitational Waves to Observe Relativity
NASA Astrophysics Data System (ADS)
Kitagawa, Midori; Kesden, Michael; Tranm, Ngoc; Venlayudam, Thulasi Sivampillai; Urquhart, Mary; Malina, Roger
2017-05-01
In 2015, a century after Albert Einstein published his theory of general relativity, the Laser Interferometer Gravitational-wave Observatory (LIGO) detected gravitational waves from binary black holes fully consistent with this theory. Our goal for VIGOR (Virtual-reality Interaction with Gravitational waves to Observe Relativity) is to communicate this revolutionary discovery to the public by visualizing the gravitational waves emitted by binary black holes. VIGOR has been developed using the Unity game engine and VR headsets (Oculus Rift DK2 and Samsung Gear VR). Wearing a VR headset, VIGOR users control an avatar to "fly" around binary black holes, experiment on the black holes by manipulating their total mass, mass ratio, and orbital separation, and witness how gravitational waves emitted by the black holes stretch and squeeze the avatar. We evaluated our prototype of VIGOR with high school students in 2016 and are further improving VIGOR based on our findings.
NASA Astrophysics Data System (ADS)
Luo, Xin; Lu, Xin; Koon, Gavin Kok Wai; Castro Neto, Antonio H.; Özyilmaz, Barbaros; Xiong, Qihua; Quek, Su Ying
2015-06-01
Bulk black phosphorus (BP) consists of puckered layers of phosphorus atoms. Few-layer BP, obtained from bulk BP by exfoliation, is an emerging candidate as a channel material in post-silicon electronics. A deep understanding of its physical properties and its full range of applications are still being uncovered. In this paper, we present a theoretical and experimental investigation of phonon properties in few-layer BP, focusing on the low-frequency regime corresponding to interlayer vibrational modes. We show that the interlayer breathing mode A3g shows a large redshift with increasing thickness; the experimental and theoretical results agreeing well. This thickness dependence is two times larger than that in the chalcogenide materials such as few-layer MoS2 and WSe2, because of the significantly larger interlayer force constant and smaller atomic mass in BP. The derived interlayer out-of-plane force constant is about 50% larger than that in graphene and MoS2. We show that this large interlayer force constant arises from the sizable covalent interaction between phosphorus atoms in adjacent layers, and that interlayer interactions are not merely of the weak van der Waals type. These significant interlayer interactions are consistent with the known surface reactivity of BP, and have been shown to be important for electric-field induced formation of Dirac cones in thin film BP.
Luo, Xin; Lu, Xin; Koon, Gavin Kok Wai; Castro Neto, Antonio H; Özyilmaz, Barbaros; Xiong, Qihua; Quek, Su Ying
2015-06-10
Bulk black phosphorus (BP) consists of puckered layers of phosphorus atoms. Few-layer BP, obtained from bulk BP by exfoliation, is an emerging candidate as a channel material in post-silicon electronics. A deep understanding of its physical properties and its full range of applications are still being uncovered. In this paper, we present a theoretical and experimental investigation of phonon properties in few-layer BP, focusing on the low-frequency regime corresponding to interlayer vibrational modes. We show that the interlayer breathing mode A(3)g shows a large redshift with increasing thickness; the experimental and theoretical results agree well. This thickness dependence is two times larger than that in the chalcogenide materials, such as few-layer MoS2 and WSe2, because of the significantly larger interlayer force constant and smaller atomic mass in BP. The derived interlayer out-of-plane force constant is about 50% larger than that of graphene and MoS2. We show that this large interlayer force constant arises from the sizable covalent interaction between phosphorus atoms in adjacent layers and that interlayer interactions are not merely of the weak van der Waals type. These significant interlayer interactions are consistent with the known surface reactivity of BP and have been shown to be important for electric-field induced formation of Dirac cones in thin film BP.
Observation of hard processes in rapidity gap events in γp interactions at HERA
NASA Astrophysics Data System (ADS)
Ahmed, T.; Aid, S.; Andreev, V.; Andrieu, B.; Appuhn, R.-D.; Arpagaus, M.; Babaev, A.; Baehr, J.; Bán, J.; Baranov, P.; Barrelet, E.; Bartel, W.; Barth, M.; Bassler, U.; Beck, H. P.; Behrend, H.-J.; Belousov, A.; Berger, Ch.; Bergstein, H.; Bernardi, G.; Bernet, R.; Bertrand-Coremans, G.; Besançon, M.; Beyer, R.; Biddulph, P.; Bizot, J. C.; Blobel, V.; Borras, K.; Botterweck, F.; Boudry, V.; Braemer, A.; Brasse, F.; Braunschweig, W.; Brisson, V.; Bruncko, D.; Brune, C.; Buchholz, R.; Büngener, L.; Bürger, J.; Büsser, F. W.; Buniatian, A.; Burke, S.; Buschhorn, G.; Campbell, A. J.; Carli, T.; Charles, F.; Clarke, D.; Clegg, A. B.; Clerbaux, B.; Colombo, M.; Contreras, J. G.; Coughlan, J. A.; Courau, A.; Coutures, Ch.; Cozzika, G.; Criegee, L.; Cussans, D. G.; Cvach, J.; Dagoret, S.; Dainton, J. B.; Danilov, M.; Dau, W. D.; Daum, K.; David, M.; Deffur, E.; Delcourt, B.; Del Buono, L.; De Roeck, A.; De Wolf, E. A.; Di Nezza, P.; Dollfus, C.; Dowell, J. D.; Dreis, H. B.; Droutskoi, V.; Duboc, J.; Düllmann, D.; Dünger, O.; Duhm, H.; Ebert, J.; Ebert, T. R.; Eckerlin, G.; Efremenko, V.; Egli, S.; Ehrlichmann, H.; Eichenberger, S.; Eichler, R.; Eisele, F.; Eisenhandler, E.; Ellison, R. J.; Elsen, E.; Erdmann, M.; Erdmann, W.; Evrard, E.; Favart, L.; Fedotov, A.; Feeken, D.; Felst, R.; Feltesse, J.; Ferencei, J.; Ferrarotto, F.; Flamm, K.; Fleischer, M.; Flieser, M.; Flügge, G.; Fomenko, A.; Fominykh, B.; Forbush, M.; Formánek, J.; Foster, J. M.; Franke, G.; Fretwurst, E.; Gabathuler, E.; Gabathuler, K.; Gamerdinger, K.; Garvey, J.; Gayler, J.; Gebauer, M.; Gellrich, A.; Genzel, H.; Gerhards, R.; Goerlach, U.; Goerlach, L.; Gogitidze, N.; Goldberg, M.; Goldner, D.; Gonzalez-Pineiro, B.; Goodall, A. M.; Gorelov, I.; Goritchev, P.; Grab, C.; Grässler, H.; Grässler, R.; Greenshaw, T.; Grindhammer, G.; Gruber, A.; Gruber, C.; Haack, J.; Haidt, D.; Hajduk, L.; Hamon, O.; Hampel, M.; Hanlon, E. M.; Hapke, M.; Haynes, W. J.; Heatherington, J.; Heinzelmann, G.; Henderson, R. C. W.; Henschel, H.; Herma, R.; Herynek, I.; Hess, M. F.; Hildesheim, W.; Hill, P.; Hiller, K. H.; Hilton, C. D.; Hladký, J.; Hoeger, K. C.; Höppner, M.; Horisberger, R.; Huet, Ph.; Hufnagel, H.; Ibbotson, M.; Itterbeck, H.; Jabiol, M.-A.; Jacholkowska, A.; Jacobsson, C.; Jaffre, M.; Janoth, J.; Jansen, T.; Jönsson, L.; Johannsen, K.; Johnson, D. P.; Johnson, L.; Jung, H.; Kalmus, P. I. P.; Kant, D.; Kaschowitz, R.; Kasselmann, P.; Kathage, U.; Kaufmann, H. H.; Kazarian, S.; Kenyon, I. R.; Kermiche, S.; Keuker, C.; Kiesling, C.; Klein, M.; Kleinwort, C.; Knies, G.; Ko, W.; Köhler, T.; Kolanoski, H.; Kole, F.; Kolya, S. D.; Korbel, V.; Korn, M.; Kostka, P.; Kotelnikov, S. K.; Krämerkämper, T.; Krasny, M. W.; Krehbiel, H.; Krücker, D.; Krüger, U.; Krüner-Marquis, U.; Kubenka, J. P.; Küster, H.; Kuhlen, M.; Kurča, T.; Kurzhöfer, J.; Kuznik, B.; Lacour, D.; Lamarche, F.; Lander, R.; Landon, M. P. J.; Lange, W.; Lanius, P.; Laporte, J.-F.; Lebedev, A.; Leverenz, C.; Levonian, S.; Ley, Ch.; Lindner, A.; Lindström, G.; Linsel, F.; Lipinski, J.; List, B.; Loch, P.; Lohmander, H.; Lopez, G. C.; Lubimov, V.; Lüke, D.; Magnussen, N.; Malinovski, E.; Mani, S.; Maraček, R.; Marage, P.; Marks, J.; Marshall, R.; Martens, J.; Martin, R.; Martyn, H.-U.; Martyniak, J.; Masson, S.; Mavroidis, T.; Maxfield, S. J.; McMahon, S. J.; Mehta, A.; Meier, K.; Mercer, D.; Merz, T.; Meyer, C. A.; Meyer, H.; Meyer, J.; Mikocki, S.; Milstead, D.; Moreau, F.; Morris, J. V.; Müller, G.; Müller, K.; Murín, P.; Nagovizin, V.; Nahnhauer, R.; Naroska, B.; Naumann, Th.; Newman, P. R.; Newton, D.; Neyret, D.; Nguyen, H. K.; Niebergall, F.; Niebuhr, C.; Nisius, R.; Nowak, G.; Noyes, G. W.; Nyberg-Werther, M.; Oberlack, H.; Obrock, U.; Olsson, J. E.; Panaro, E.; Panitch, A.; Pascaud, C.; Patel, G. D.; Peppel, E.; Perez, E.; Phillips, J. P.; Pichler, Ch.; Pitzl, D.; Pope, G.; Prell, S.; Prosi, R.; Rädel, G.; Raupach, F.; Reimer, P.; Reinshagen, S.; Ribarics, P.; Rick, H.; Riech, V.; Riedlberger, J.; Riess, S.; Rietz, M.; Robertson, S. M.; Robmann, P.; Roloff, H. E.; Roosen, R.; Rosenbauer, K.; Rostovtsev, A.; Rouse, F.; Royon, C.; Rüter, K.; Rusakov, S.; Rybicki, K.; Rylko, R.; Sahlmann, N.; Sanchez, E.; Sankey, D. P. C.; Savitsky, M.; Schacht, P.; Schiek, S.; Schleper, P.; von Schlippe, W.; Schmidt, C.; Schmidt, D.; Schmidt, G.; Schöning, A.; Schröder, V.; Schuhmann, E.; Schwab, B.; Schwind, A.; Seehausen, U.; Sefkow, F.; Seidel, M.; Sell, R.; Semenov, A.; Shekelyan, V.; Sheviakov, I.; Shooshtari, H.; Shtarkov, L. N.; Siegmon, G.; Siewert, U.; Sirois, Y.; Skillicorni, I. O.; Smirnov, P.; Smith, J. R.; Soloviev, Y.; Spitzer, H.; Starosta, R.; Steenbock, M.; Steffen, P.; Steinberg, R.; Stella, B.; Stephens, K.; Stier, J.; Stiewe, J.; Stösslein, U.; Strachota, J.; Straumann, U.; Struczinski, W.; Sutton, J. P.; Tapprogge, S.; Taylor, R. E.; Tchernyshov, V.; Thiebaux, C.; Thompson, G.; Truöl, P.; Turnau, J.; Tutas, J.; Uelkes, P.; Usik, A.; Valkár, S.; Valkárová, A.; Vallée, C.; Van Esch, P.; Van Mechelen, P.; Vartapetian, A.; Vazdik, Y.; Vecko, M.; Verrecchia, P.; Villet, G.; Wacker, K.; Wagener, A.; Wagener, M.; Walker, I. W.; Walther, A.; Weber, G.; Weber, M.; Wegener, D.; Wegner, A.; Wellisch, H. P.; West, L. R.; Willard, S.; Winde, M.; Winter, G.-G.; Wright, A. E.; Wünsch, E.; Wulff, N.; Yiou, T. P.; Žáček, J.; Zarbock, D.; Zhang, Z.; Zhokin, A.; Zimmer, M.; Zimmermann, W.; Zomer, F.; Zuber, K.
1995-02-01
Events with no hadronic energy flow in a large interval of pseudo-rapidity in the proton direction are observed in photon-proton interactions at an average centre of mass energy <√s γp> of 200 GeV These events are interpreted as photon diffractive dissociation. Evidence for hard scattering in photon diffractive dissociation is demonstrated using inclusive single particle spectra, thrust as a function of transverse energy, and the observation of jet production. The data can be described by a Monte Carlo calculation including hard photon-pomeron scattering.
An interactive environment for the analysis of large Earth observation and model data sets
NASA Technical Reports Server (NTRS)
Bowman, Kenneth P.; Walsh, John E.; Wilhelmson, Robert B.
1993-01-01
We propose to develop an interactive environment for the analysis of large Earth science observation and model data sets. We will use a standard scientific data storage format and a large capacity (greater than 20 GB) optical disk system for data management; develop libraries for coordinate transformation and regridding of data sets; modify the NCSA X Image and X DataSlice software for typical Earth observation data sets by including map transformations and missing data handling; develop analysis tools for common mathematical and statistical operations; integrate the components described above into a system for the analysis and comparison of observations and model results; and distribute software and documentation to the scientific community.
An interactive environment for the analysis of large Earth observation and model data sets
NASA Technical Reports Server (NTRS)
Bowman, Kenneth P.; Walsh, John E.; Wilhelmson, Robert B.
1992-01-01
We propose to develop an interactive environment for the analysis of large Earth science observation and model data sets. We will use a standard scientific data storage format and a large capacity (greater than 20 GB) optical disk system for data management; develop libraries for coordinate transformation and regridding of data sets; modify the NCSA X Image and X Data Slice software for typical Earth observation data sets by including map transformations and missing data handling; develop analysis tools for common mathematical and statistical operations; integrate the components described above into a system for the analysis and comparison of observations and model results; and distribute software and documentation to the scientific community.
The Effects of Three Methods of Observation on Couples in Interactional Research.
ERIC Educational Resources Information Center
Carpenter, Linda J.; Merkel, William T.
1988-01-01
Assessed the effects of three different methods of observation of couples (one-way mirror, audio recording, and video recording) on 30 volunteer, nonclinical married couples. Results suggest that types of observation do not produce significantly different effects on nonclinical couples. (Author/ABL)
Besalú, Emili
2016-01-01
The Superposing Significant Interaction Rules (SSIR) method is described. It is a general combinatorial and symbolic procedure able to rank compounds belonging to combinatorial analogue series. The procedure generates structure-activity relationship (SAR) models and also serves as an inverse SAR tool. The method is fast and can deal with large databases. SSIR operates from statistical significances calculated from the available library of compounds and according to the previously attached molecular labels of interest or non-interest. The required symbolic codification allows dealing with almost any combinatorial data set, even in a confidential manner, if desired. The application example categorizes molecules as binding or non-binding, and consensus ranking SAR models are generated from training and two distinct cross-validation methods: leave-one-out and balanced leave-two-out (BL2O), the latter being suited for the treatment of binary properties. PMID:27240346
NASA Astrophysics Data System (ADS)
Didiş Körhasan, Nilüfer; Eryılmaz, Ali; Erkoç, Şakir
2016-01-01
Mental models are coherently organized knowledge structures used to explain phenomena. They interact with social environments and evolve with the interaction. Lacking daily experience with phenomena, the social interaction gains much more importance. In this part of our multiphase study, we investigate how instructional interactions influenced students’ mental models about the quantization of physical observables. Class observations and interviews were analysed by studying students’ mental models constructed in a modern physics course during an academic semester. The research revealed that students’ mental models were influenced by (1) the manner of teaching, including instructional methodologies and content specific techniques used by the instructor, (2) order of the topics and familiarity with concepts, and (3) peers.
Liu, Dong-cai; Yang, Zhu-lin
2011-11-01
Gallbladder cancers are aggressive tumors with a poor prognosis and high mortality rate. To find specific biological markers for early diagnosis and prognosis and to develop possible alternative treatment strategies, we examined minichromosome maintenance protein 2 (MCM2) and Tat-interacting protein 30 (TIP30) expression in 108 gallbladder adenocarcinomas, 15 gallbladder polyps, 35 chronic cholecystitis tissues, and 46 peritumoral tissues using immunohistochemistry. Expression of MCM2 was significantly higher in adenocarcinomas than in peritumoral tissues (χ² = 8.41; P < .01), adenomatous polyps (χ² = 6.81; P < .01), and chronic cholecystitis (χ² = 21.00; P < .01). In contrast, Tat-interacting protein 30 expression was significantly less in adenocarcinomas than in peritumoral tissues (χ² = 13.26; P < .01), adenomatous polyps (χ² = 4.76; P < .05), and chronic cholecystitis (χ² = 18.93; P < .01). The benign lesions in gallbladder epithelium with positive MCM2 or negative Tat-interacting protein 30 expression showed moderate to severe atypical hyperplasia. Expression of MCM2 and absence of Tat-interacting protein 30 were significantly associated with poor differentiation, large tumor mass, lymph node metastasis, and invasion of adenocarcinoma. Univariate Kaplan-Meier analysis showed that either elevated MCM2 (P = .006) or lowered Tat-interacting protein 30 (P = .006) expression was closely associated with shorter overall survival. Multivariate Cox regression analysis revealed that expression of MCM2 (P = .007) or nonexpression of Tat-interacting protein 30 (P = .009) was an independent predictor of a poor prognosis in adenocarcinoma. Our results suggest that overexpression of MCM2 or loss of expression of Tat-interacting protein 30 is closely related to carcinogenesis, progression, biological behavior, and prognosis of gallbladder adenocarcinoma. Copyright © 2011 Elsevier Inc. All rights reserved.
Wuchty, Stefan
2006-05-23
While the analysis of unweighted biological webs as diverse as genetic, protein and metabolic networks allowed spectacular insights in the inner workings of a cell, biological networks are not only determined by their static grid of links. In fact, we expect that the heterogeneity in the utilization of connections has a major impact on the organization of cellular activities as well. We consider a web of interactions between protein domains of the Protein Family database (PFAM), which are weighted by a probability score. We apply metrics that combine the static layout and the weights of the underlying interactions. We observe that unweighted measures as well as their weighted counterparts largely share the same trends in the underlying domain interaction network. However, we only find weak signals that weights and the static grid of interactions are connected entities. Therefore assuming that a protein interaction is governed by a single domain interaction, we observe strong and significant correlations of the highest scoring domain interaction and the confidence of protein interactions in the underlying interactions of yeast and fly. Modeling an interaction between proteins if we find a high scoring protein domain interaction we obtain 1, 428 protein interactions among 361 proteins in the human malaria parasite Plasmodium falciparum. Assessing their quality by a logistic regression method we observe that increasing confidence of predicted interactions is accompanied by high scoring domain interactions and elevated levels of functional similarity and evolutionary conservation. Our results indicate that probability scores are randomly distributed, allowing to treat static grid and weights of domain interactions as separate entities. In particular, these finding confirms earlier observations that a protein interaction is a matter of a single interaction event on domain level. As an immediate application, we show a simple way to predict potential protein interactions
Lazary, Judit
2017-12-01
Although genetic studies have improved a lot in recent years, without clinical relevance sometimes their significance is devalued. Reviewing the major milestones of psychogenomics it can be seen that break-through success is just a question of time. Investigations of direct effect of genetic variants on phenotypes have not yielded positive findings. However, an important step was taken by adapting the gene-environment interaction model. In this model genetic vulnerability stepped into the place of "stone craved" pathology. Further progress happened when studies of environmental factors were combined with genetic function (epigenetics). This model provided the possibility for investigation of therapeutic interventions as environmental factors and it was proven that effective treatments exert a modifying effect on gene expression. Moreover, recent developments focus on therapeutic manipulation of gene function (e.g. chemogenetics). Instead of "stone craved" genes up-to-date dynamically interacting gene function became the basis of psychogenomics in which correction of the expression is a potential therapeutic tool. Keeping in mind these trends and developments, there is no doubt that genetics will be a fundamental part of daily clinical routine in the future.
Does Social Interaction Matter Psychological Well-Being in Persons With Dementia?
Lee, Kyung Hee; Boltz, Marie; Lee, Hana; Algase, Donna L
2017-06-01
Social interaction between residents and staff is an important factor influencing sense of well-being. This study examined the relationship between staff-resident interactions and psychological well-being of persons with dementia. A total of 831 observations of 110 persons with dementia in 17 nursing homes and 6 assisted living facilities were included. Psychological well-being was measured by observed displays of positive and negative emotional expressions. Social interaction was determined by the type of social interaction (ie, verbal interaction, nonverbal interaction, and both verbal and nonverbal interactions) and the quality of interaction (ie, positive, negative, and neutral). Verbal or both verbal and nonverbal interactions showed significant relationship with positive and negative emotional expressions. Positive interaction was significantly associated with more positive emotional expression, whereas negative interaction was not. Staff-resident interactions are important to promote the psychological well-being of persons with dementia in residential care.
Browne, Dillon T; Leckie, George; Prime, Heather; Perlman, Michal; Jenkins, Jennifer M
2016-07-01
The present study sought to investigate the family, individual, and dyad-specific contributions to observed cognitive sensitivity during family interactions. Moreover, the influence of cumulative risk on sensitivity at the aforementioned levels of the family was examined. Mothers and 2 children per family were observed interacting in a round robin design (i.e., mother-older sibling, mother younger-sibling and sibling-dyad, N = 385 families). Data were dyadic, in that there were 2 directional scores per interaction, and were analyzed using a multilevel formulation of the Social Relations Model. Variance partitioning revealed that cognitive sensitivity is simultaneously a function of families, individuals and dyads, though the importance of these components varies across family roles. Cognitive sensitivity for mothers was primarily attributable to individual differences, whereas cognitive sensitivity for children was predominantly attributable to family and dyadic differences, especially for youngest children. Cumulative risk explained family and individual variance in cognitive sensitivity, particularly when actors were older or in a position of relative competence or authority (i.e., mother to children, older to younger siblings). Overall, this study demonstrates that cognitive sensitivity operates across levels of family organization, and is negatively impacted by psychosocial risk. (PsycINFO Database Record (c) 2016 APA, all rights reserved).
Shen, Li; Saykin, Andrew J.; Williams, Scott M.; Moore, Jason H.
2016-01-01
ABSTRACT Although gene‐environment (G× E) interactions play an important role in many biological systems, detecting these interactions within genome‐wide data can be challenging due to the loss in statistical power incurred by multiple hypothesis correction. To address the challenge of poor power and the limitations of existing multistage methods, we recently developed a screening‐testing approach for G× E interaction detection that combines elastic net penalized regression with joint estimation to support a single omnibus test for the presence of G× E interactions. In our original work on this technique, however, we did not assess type I error control or power and evaluated the method using just a single, small bladder cancer data set. In this paper, we extend the original method in two important directions and provide a more rigorous performance evaluation. First, we introduce a hierarchical false discovery rate approach to formally assess the significance of individual G× E interactions. Second, to support the analysis of truly genome‐wide data sets, we incorporate a score statistic‐based prescreening step to reduce the number of single nucleotide polymorphisms prior to fitting the first stage penalized regression model. To assess the statistical properties of our method, we compare the type I error rate and statistical power of our approach with competing techniques using both simple simulation designs as well as designs based on real disease architectures. Finally, we demonstrate the ability of our approach to identify biologically plausible SNP‐education interactions relative to Alzheimer's disease status using genome‐wide association study data from the Alzheimer's Disease Neuroimaging Initiative (ADNI). PMID:27578615
NASA Technical Reports Server (NTRS)
Xu, C.; Gao, Y.; Mazzarella, J.; Lu, N.; Sulentic, J.; Domingue, D.
2000-01-01
Mid-infrared (MIR) imaging and spectroscopic observations are presented for a well defined sample of eight closely interacting (CLO) pairs of spiral galaxies that have overlapping disks and show enhanced far-infrared (FIR) emission.
Describing the observed cosmic neutrinos by interactions of nuclei with matter
NASA Astrophysics Data System (ADS)
Winter, Walter
2014-11-01
IceCube has observed neutrinos that are presumably of extra-Galactic origin. Since specific sources have not yet been identified, we discuss what could be learned from the conceptual point of view. We use a simple model for neutrino production from the interactions between nuclei and matter, and we focus on the description of the spectral shape and flavor composition observed by IceCube. Our main parameters are the spectral index, maximal energy, magnetic field, and composition of the accelerated nuclei. We show that a cutoff at PeV energies can be achieved by soft enough spectra, a cutoff of the primary energy, or strong enough magnetic fields. These options, however, are difficult to reconcile with the hypothesis that these neutrinos originate from the same sources as the ultrahigh-energy cosmic rays. We demonstrate that heavier nuclei accelerated in the sources may be a possible way out if the maximal energy scales appropriately with the mass number of the nuclei. In this scenario, neutrino observations can actually be used to test the ultrahigh-energy cosmic ray acceleration mechanism. We also emphasize the need for a volume upgrade of the IceCube detector for future precision physics, for which the flavor information becomes a statistically meaningful model discriminator as well as a qualitatively new ingredient.
Single molecule FRET observation of kinesin-1’s head-tail interaction on microtubule
Aoki, Takahiro; Tomishige, Michio; Ariga, Takayuki
2013-01-01
Kinesin-1 (conventional kinesin) is a molecular motor that transports various cargo such as endoplasmic reticulum and mitochondria in cells. Its two head domains walk along microtubule by hydrolyzing ATP, while the tail domains at the end of the long stalk bind to the cargo. When a kinesin is not carrying cargo, its motility and ATPase activity is inhibited by direct interactions between the tail and head. However, the mechanism of this tail regulation is not well understood. Here, we apply single molecule fluorescence resonance energy transfer (smFRET) to observe this interaction in stalk-truncated kinesin. We found that kinesin with two tails forms a folding conformation and dissociates from microtubules, whereas kinesin with one tail remains bound to the micro-tubule and is immobile even in the presence of ATP. We further investigated the head-tail interaction as well as head-head coordination on the microtubule at various nucleotide conditions. From these results, we propose a two-step inhibition model for kinesin motility. PMID:27493553
Wang, Shu-Wen; Repetti, Rena L
2016-06-01
We examined sex differences in explicitly supportive behavior exchanges between husbands and wives using naturalistic video-recordings of everyday couple interactions inside the home. Thirty dual-earner, middle class, heterosexual couples with school-age children were recorded in their homes over 4 days. Specific instances of face-to-face explicit couple support in the video-recordings were identified, and the support role assumed by each partner (recipient vs. provider), the method of support initiation (solicitations vs. offers), and the type of support (instrumental vs. emotional) in each interaction were coded. Paired samples t tests examined sex differences in husbands' and wives' supportive behavior, and bivariate correlations tested the associations among spouses' support initiation behaviors. Findings counter prior research that has largely found a "support gap" favoring husbands as support recipients. Instead, results indicate that wives received significantly more support of an instrumental nature from husbands (than husbands did from wives), a finding driven by wives' active support-soliciting behavior. Among husbands, a tendency to be the solicitor of support was positively correlated with a tendency to offer support. Within couples, rates of offers of support by 1 spouse were correlated with offers by the partner. Naturalistic observations highlight processes that may not be detected by self-reports or laboratory data, in an ecologically valid context in which social behavior reflects the natural rhythms and pulls of everyday life. (PsycINFO Database Record (c) 2016 APA, all rights reserved).
Zhang, X; Bishof, M; Bromley, S L; Kraus, C V; Safronova, M S; Zoller, P; Rey, A M; Ye, J
2014-09-19
SU(N) symmetry can emerge in a quantum system with N single-particle spin states when spin is decoupled from interparticle interactions. Taking advantage of the high measurement precision offered by an ultrastable laser, we report a spectroscopic observation of SU(N ≤ 10) symmetry in (87)Sr. By encoding the electronic orbital degree of freedom in two clock states while keeping the system open to as many as 10 nuclear spin sublevels, we probed the non-equilibrium two-orbital SU(N) magnetism via Ramsey spectroscopy of atoms confined in an array of two-dimensional optical traps; we studied the spin-orbital quantum dynamics and determined the relevant interaction parameters. This study lays the groundwork for using alkaline-earth atoms as testbeds for important orbital models. Copyright © 2014, American Association for the Advancement of Science.
Van Keer, Ines; Colla, Stephy; Van Leeuwen, Karla; Vlaskamp, Carla; Ceulemans, Eva; Hoppenbrouwers, Karel; Desoete, Annemie; Maes, Bea
2017-05-01
Parenting factors are one of the most striking gaps in the current scientific literature on the development of young children with significant cognitive and motor disabilities. We aim to explore the characteristics of, and the association between, parental behavior and children's interactive engagement within this target group. Twenty-five parent-child dyads (with children aged 6-59 months) were video-taped during a 15-min unstructured play situation. Parents were also asked to complete the Parental Behavior Scale for toddlers. The video-taped observations were scored using the Child and Maternal Behavior Rating Scales. Low levels of parental discipline and child initiation were found. Parental responsivity was positively related to child attention and initiation. Compared to children with no or other levels of disabilities, this target group exhibits large differences in frequency levels and, to a lesser extent, the concrete operationalization of parenting domains. Further, this study confirms the importance of sensitive responsivity as the primary variable in parenting research. Copyright © 2017 Elsevier Ltd. All rights reserved.
Photometric observations of local rocket-atmosphere interactions
NASA Astrophysics Data System (ADS)
Greer, R. G. H.; Murtagh, D. P.; Witt, G.; Stegman, J.
1983-06-01
Photometric measurements from rocket flights which recorded a strong foreign luminance in the altitude region between 90 and 130 km are reported. From one Nike-Orion rocket the luminance appeared on both up-leg and down-leg; from a series of Petrel rockets the luminance was apparent only on the down-leg. The data suggest that the luminance may be distributed mainly in the wake region along the rocket trajectory. The luminance is believed to be due to a local interaction between the rocket and the atmosphere although the precise nature of the interaction is unknown. It was measured at wavelengths ranging from 275 nm to 1.61 microns and may be caused by a combination of reactions.
NASA Astrophysics Data System (ADS)
Quetin, Gregory R.
The natural composition of terrestrial ecosystems can be shaped by climate to take advantage of local environmental conditions. Ecosystem functioning, e.g. interaction between photosynthesis and temperature, can also acclimate to different climatological states. The combination of these two factors thus determines ecological-climate interactions. The ecosystem functioning also plays a key role in predicting the carbon cycle, hydrological cycle, terrestrial surface energy balance, and the feedbacks in the climate system. Predicting the response of the Earth's biosphere to global warming requires the ability to mechanistically represent the processes controlling ecosystem functioning through photosynthesis, respiration, and water use. The physical environment in a place shapes the vegetation there, but vegetation also has the potential to shape the environment, e.g. increased photosynthesis and transpiration moisten the atmosphere. These two-way ecoclimate interactions create the potential for feedbacks between vegetation at the physical environment that depend on the vegetation and the climate of a place, and can change throughout the year. In Chapter 1, we derive a global empirical map of the sensitivity of vegetation to climate using the response of satellite-observed greenness to interannual variations in temperature and precipitation. We infer mechanisms constraining ecosystem functioning by analyzing how the sensitivity of vegetation to climate varies across climate space. Our analysis yields empirical evidence for multiple physical and biological mediators of the sensitivity of vegetation to climate at large spatial scales. In hot and wet locations, vegetation is greener in warmer years despite temperatures likely exceeding thermally optimum conditions. However, sunlight generally increases during warmer years, suggesting that the increased stress from higher atmospheric water demand is offset by higher rates of photosynthesis. The sensitivity of vegetation
NASA Astrophysics Data System (ADS)
Khabarova, Olga; Malandraki, Olga; Zank, Gary; Jackson, Bernard; Bisi, Mario; Desai, Mihir; Li, Gang; le Roux, Jakobus; Yu, Hsiu-Shan
2017-04-01
Recent studies of mechanisms of particle acceleration in the heliosphere have revealed the importance of the comprehensive analysis of stream-stream interactions as well as the heliospheric current sheet (HCS) - stream interactions that often occur in the solar wind, producing huge magnetic cavities bounded by strong current sheets. Such cavities are usually filled with small-scale magnetic islands that trap and re-accelerate energetic particles (Zank et al. ApJ, 2014, 2015; le Roux et al. ApJ, 2015, 2016; Khabarova et al. ApJ, 2015, 2016). Crossings of these regions are associated with unusual variations in the energetic particle flux up to several MeV/nuc near the Earth's orbit. These energetic particle flux enhancements called "atypical energetic particle events" (AEPEs) are not associated with standard mechanisms of particle acceleration. The analysis of multi-spacecraft measurements of energetic particle flux, plasma and the interplanetary magnetic field shows that AEPEs have a local origin as they are observed by different spacecraft with a time delay corresponding to the solar wind propagation from one spacecraft to another, which is a signature of local particle acceleration in the region embedded in expanding and rotating background solar wind. AEPEs are often observed before the arrival of corotating interaction regions (CIRs) or stream interaction regions (SIRs) to the Earth's orbit. When fast solar wind streams catch up with slow solar wind, SIRs of compressed heated plasma or more regular CIRs are created at the leading edge of the high-speed stream. Since coronal holes are often long-lived structures, the same CIR re-appears often for several consecutive solar rotations. At low heliographic latitudes, such CIRs are typically bounded by forward and reverse waves on their leading and trailing edges, respectively, that steepen into shocks at heliocentric distances beyond 1 AU. Energetic ion increases have been frequently observed in association with CIR
Kojima, Y
2000-01-01
Characteristics of three maternal regulating behaviors--(1) reference to one sibling's actions or emotional states toward the other sibling, (2) encouragement of sibling interactions, (3) distraction of one sibling's attention away from the other sibling-and their associations with children's positive and negative behaviors toward their siblings were investigated through semistructured home observations for 40 sibling pairs (1-4 years, 2-8 years) and their mothers in Japanese families. Maternal regulating behaviors were observed more frequently when the younger sibling was still in an early developmental stage in the preschool years, although the findings were modest. The older sibling's negative behaviors toward the younger sibling positively correlated with maternal distraction toward the younger; alternatively, the younger sibling's negative behaviors do not correlate with maternal distraction but do correlate with maternal encouragement directed toward the older sibling. Reliable associations were found between maternal regulating behaviors and prosocial exchanges between siblings; maternal reference to the younger sibling's actions or emotional states directed toward the older sibling was associated with the older sibling's positive behavior toward the younger sibling. Maternal regulating behaviors during mother-sibling triadic interactions were associated with the quality of sibling relationships.
Direct observation of growth and collapse of a Bose-Einstein condensate with attractive interactions
NASA Astrophysics Data System (ADS)
Gerton, Jordan M.; Strekalov, Dmitry; Prodan, Ionut; Hulet, Randall G.
2000-12-01
Quantum theory predicts that Bose-Einstein condensation of a spatially homogeneous gas with attractive interactions is precluded by a conventional phase transition into either a liquid or solid. When confined to a trap, however, such a condensate can form, provided that its occupation number does not exceed a limiting value. The stability limit is determined by a balance between the self-attractive forces and a repulsion that arises from position-momentum uncertainty under conditions of spatial confinement. Near the stability limit, self-attraction can overwhelm the repulsion, causing the condensate to collapse. Growth of the condensate is therefore punctuated by intermittent collapses that are triggered by either macroscopic quantum tunnelling or thermal fluctuation. Previous observations of growth and collapse dynamics have been hampered by the stochastic nature of these mechanisms. Here we report direct observations of the growth and subsequent collapse of a 7Li condensate with attractive interactions, using phase-contrast imaging. The success of the measurement lies in our ability to reduce the stochasticity in the dynamics by controlling the initial number of condensate atoms using a two-photon transition to a diatomic molecular state.
Observations & modeling of solar-wind/magnetospheric interactions
NASA Astrophysics Data System (ADS)
Hoilijoki, Sanni; Von Alfthan, Sebastian; Pfau-Kempf, Yann; Palmroth, Minna; Ganse, Urs
2016-07-01
The majority of the global magnetospheric dynamics is driven by magnetic reconnection, indicating the need to understand and predict reconnection processes and their global consequences. So far, global magnetospheric dynamics has been simulated using mainly magnetohydrodynamic (MHD) models, which are approximate but fast enough to be executed in real time or near-real time. Due to their fast computation times, MHD models are currently the only possible frameworks for space weather predictions. However, in MHD models reconnection is not treated kinetically. In this presentation we will compare the results from global kinetic (hybrid-Vlasov) and global MHD simulations. Both simulations are compared with in-situ measurements. We will show that the kinetic processes at the bow shock, in the magnetosheath and at the magnetopause affect global dynamics even during steady solar wind conditions. Foreshock processes cause an asymmetry in the magnetosheath plasma, indicating that the plasma entering the magnetosphere is not symmetrical on different sides of the magnetosphere. Behind the bow shock in the magnetosheath kinetic wave modes appear. Some of these waves propagate to the magnetopause and have an effect on the magnetopause reconnection. Therefore we find that kinetic phenomena have a significant role in the interaction between the solar wind and the magnetosphere. While kinetic models cannot be executed in real time currently, they could be used to extract heuristics to be added in the faster MHD models.
MAVEN observations of the Mars upper atmosphere, ionosphere, and solar wind interactions
NASA Astrophysics Data System (ADS)
Jakosky, Bruce M.
2017-09-01
The Mars Atmosphere and Volatile Evolution (MAVEN) mission to Mars has been operating in orbit for more than a full Martian year. Observations are dramatically changing our view of the Mars upper atmosphere system, which includes the upper atmosphere, ionosphere, coupling to the lower atmosphere, magnetosphere, and interactions with the Sun and the solar wind. The data are allowing us to understand the processes controlling the present-day structure of the upper atmosphere and the rates of escape of gas to space. These will tell us the role that escape to space has played in the evolution of the Mars atmosphere and climate.
Small is different: RPC observations of a small scale comet interacting with the solar wind
NASA Astrophysics Data System (ADS)
Nilsson, Hans; Burch, James L.; Carr, Christopher M.; Eriksson, Anders I.; Glassmeier, Karl-Heinz; Henri, Pierre; Rosetta Plasma Consortium Team
2016-10-01
Rosetta followed comet 67P from low activity at more than 3 AU heliocentric distance to peak activity at perihelion and then out again. We study the evolution of the dynamic plasma environment using data from the Rosetta Plasma Consortium (RPC). Observations of cometary plasma began in August 2014, at a distance of 100 km from the comet nucleus and at 3.6 AU from the Sun. As the comet approached the Sun, outgassing from the comet increased, as did the density of the cometary plasma. Measurements showed a highly heterogeneous cold ion environment, permeated by the solar wind. The solar wind was deflected due to the mass loading from newly added cometary plasma, with no discernible slowing down. The magnetic field magnitude increased significantly above the background level, and strong low frequency waves were observed in the magnetic field, a.k.a. the "singing comet". Electron temperatures were high, leading to a frequently strongly negative spacecraft potential. In mid to late April 2015 the solar wind started to disappear from the observation region. This was associated with a solar wind deflection reaching nearly 180°, indicating that mass loading became efficient enough to form a solar wind-free region. Accelerated water ions, moving mainly in the anti-sunward direction, kept being observed also after the solar wind disappearance. Plasma boundaries began to form and a collisionopause was tentatively identified in the ion and electron data. At the time around perihelion, a diamagnetic cavity was also observed, at a surprisingly large distance from the comet. In late 2016 the solar wind re-appeared at the location of Rosetta, allowing for studies of asymmetry of the comet ion environment with respect to perihelion. A nightside excursion allowed us to get a glimpse of the electrodynamics of the innermost part of the plasma tail. Most of these phenomena are dependent on the small-scale physics of comet 67P, since for most of the Rosetta mission the solar wind
Observing the Interactive Qualities of L2 Instructional Practices in ESL and FSL Classrooms
ERIC Educational Resources Information Center
Zuniga, Michael; Simard, Daphnée
2016-01-01
Discourse features that promote the generation of interactionally modified input and output, such as negotiation for meaning, have been shown to significantly enhance second language acquisition. Research has also identified several characteristics of instructional practices that render them more or less propitious to the generation of these…
NASA Astrophysics Data System (ADS)
De Marco, Luigi; Haky, Andrew; Tokmakoff, Andrei
Two-dimensional infrared (2D IR) spectroscopy has proven itself an indispensable tool for studying molecular dynamics and intermolecular interactions on ultrafast timescales. Using a novel source of broadband mid-IR pulses, we have collected 2D IR spectra of protein films at varying levels of hydration. With 2D IR, we can directly observe coupling between water's motions and the protein's. Protein films provide us with the ability to discriminate hydration waters from bulk water and thus give us access to studying water dynamics along the protein backbone, fluctuations in the protein structure, and the interplay between the molecular dynamics of the two. We present two representative protein films: poly-L-proline (PLP) and hen egg-white lysozyme (HEWL). Having no N-H groups, PLP allows us to look at water dynamics without interference from resonant energy transfer between the protein N-H stretch and the water O-H stretch. We conclude that at low hydration levels water-protein interactions dominate, and the water's dynamics are tied to those of the protein. In HEWL films, we take advantage of the robust secondary structure to partially deuterate the film, allowing us to spectrally distinguish the protein core from the exterior. From this, we show that resonant energy transfer to water provides an effective means of dissipating excess energy within the protein, while maintaining the structure. These methods are general and can easily be extended to studying specific protein-water interactions.
Significance of likes: Analysing passive interactions on Facebook during campaigning
2017-01-01
With more and more political candidates using social media for campaigning, researchers are looking at measuring the effectiveness of this medium. Most research, however, concentrates on the bare count of likes (or twitter mentions) in an attempt to correlate social media presence and winning. In this paper, we propose a novel method, Interaction Strength Plot (IntS) to measure the passive interactions between a candidate’s posts on Facebook and the users (liking the posts). Using this method on original Malaysian General Election (MGE13) and Australian Federal Elections (AFE13) Facebook Pages (FP) campaign data, we label an FP as performing well if both the posting frequency and the likes gathered are above average. Our method shows that over 60% of the MGE13 candidates and 85% of the AFE13 candidates studied in this paper had under-performing FP. Some of these FP owners would have been identified as popular based on bare count. Thus our performance chart is a vital step forward in measuring the effectiveness of online campaigning. PMID:28622350
Significance of likes: Analysing passive interactions on Facebook during campaigning.
Khairuddin, Mohammad Adib; Rao, Asha
2017-01-01
With more and more political candidates using social media for campaigning, researchers are looking at measuring the effectiveness of this medium. Most research, however, concentrates on the bare count of likes (or twitter mentions) in an attempt to correlate social media presence and winning. In this paper, we propose a novel method, Interaction Strength Plot (IntS) to measure the passive interactions between a candidate's posts on Facebook and the users (liking the posts). Using this method on original Malaysian General Election (MGE13) and Australian Federal Elections (AFE13) Facebook Pages (FP) campaign data, we label an FP as performing well if both the posting frequency and the likes gathered are above average. Our method shows that over 60% of the MGE13 candidates and 85% of the AFE13 candidates studied in this paper had under-performing FP. Some of these FP owners would have been identified as popular based on bare count. Thus our performance chart is a vital step forward in measuring the effectiveness of online campaigning.
NASA Astrophysics Data System (ADS)
Calcara, Massimo; Borgia, Andrea
2013-04-01
Current global warming theories have produced some benefits: among them, detailed studies on CO2 and its properties, possible applications and perspectives. Starting from its use as a "green solvent" (for instance in decaffeination process), to enhance system in oil recovery, to capture and storage enough amount of CO2 in geological horizon. So, a great debate is centred around this molecule. One More useful research in natural horizon studies is its theorised use in Enhanced Geothermal Systems with CO2 as the only working fluid. In any case, the CO2 characteristics should be deeply understood, before injecting a molecule prone to change easily its aggregation state at relatively shallow depth. CO2 Rock interaction becomes therefore a focal point in approaching research sectors linked in some manner to natural or induced presence of carbon dioxide in geological horizons. Possible chemical interactions between fluids and solids have always been a central topic in defining evolution of the system as a whole in terms of dissolutions, reactions, secondary mineral formation and, in case of whichever plant, scaling. Questions arise in case of presence of CO2 with host rocks. Chemical and molecular properties are strategic. CO2 Rock interactions are based on eventual solubility capability of pure liquid and supercritical CO2 seeking and eventually quantifying its polar and/or ionic solvent capabilities. Single molecule at STP condition is linear, with central carbon atom and oxygen atoms at opposite site on a straight line with a planar angle. It has a quadrupolar moment due to the electronegativity difference between carbon and oxygen. As soon as CO2 forms bond with water, it deforms even at atmospheric pressure, assuming an induced dipole moment with a value around 0.02 Debye. Hydrated CO2 forms a hydrophilic bond; it deforms with an angle of 178 degrees. Pure CO2 forms self aggregates. In the simplest case a dimer, with two molecules of CO2 exerting mutual attraction
Interaction between solar wind and lunar magnetic anomalies observed by MAP-PACE on Kaguya
NASA Astrophysics Data System (ADS)
Saito, Yoshifumi; Yokota, Shoichiro; Tanaka, Takaaki; Asamura, Kazushi; Nishino, Masaki N.; Yamamoto, Tadateru I.; Tsunakawa, Hideo
were observed, the simultaneously measured electrons were often heated and the incident solar wind ions were sometimes slightly decelerated. At 50km altitude, when the reflected ions were observed, proton scattering at the lunar surface clearly disappeared. It suggests that there exists an area on the lunar surface where solar wind does not impact. At 10km altitude, the interaction between the solar wind ions and the lunar magnetic anomalies was remarkable with clear deceleration of the incident solar wind ions and heating of the reflected ions as well as significant heating of the electrons. Calculating velocity moments including density, velocity, temperature of the ions and electrons, we have found that there exists 100km scale regions over strong magnetic anomalies where plasma parameters are quite different from the outside. Solar wind ions observed at 10km altitude show several different behaviors such as deceleration without heating and heating in a limited region inside the magnetic anomalies that may be caused by the magnetic field structure. The deceleration of the solar wind has the same ∆E/q (∆E : deceleration energy, q: charge) for different species, which constraints the possible mechanisms of the interaction between solar wind and magnetic anomalies.
Keely, Simon; Kelly, Caleb J.; Weissmueller, Thomas; Burgess, Adrianne; Wagner, Brandie D.; Robertson, Charles E.; Harris, J. Kirk; Colgan, Sean P.
2012-01-01
Within the intestinal mucosa, epithelial cells serve multiple functions to partition the lumen from the lamina propria. As part of their natural function, intestinal epithelial cells actively transport electrolytes with passive water movement as a mechanism for mucosal hydration. Here, we hypothesized that electrogenic Cl- secretion, and associated mucosal hydration, influences bacterial-epithelial interactions and significantly influences the composition of the intestinal microbiota. An initial screen of different epithelial secretagogues identified lubiprostone as the most potent agonist for which to define these principles. In in vitro studies using cultured T84 cells, lubiprostone decreased E. coli translocation in a concentration-dependent manner (p < 0.001) and decreased S. typhimurium internalization and translocation by as much as 71 ± 6% (p < 0.01). Such decreases in bacterial translocation were abolished by inhibition of electrogenic Cl- secretion and water transport using the Na-K-Cl- antagonist bumetanide (p < 0.01). Extensions of these findings to microbiome analysis in vivo revealed that lubiprostone delivered orally to mice fundamentally shifted the intestinal microbiota, with notable changes within the Firmicutes and Bacteroidetes phyla of resident colonic bacteria. Such findings document a previously unappreciated role for epithelial Cl- secretion and water transport in influencing bacterial-epithelial interactions and suggest that active mucosal hydration functions as a primitive innate epithelial defense mechanism. PMID:22614705
Yuan, Xiangyang; Shang, Bo; Xu, Yansen; Xin, Yue; Tian, Yuan; Feng, Zhaozhong; Paoletti, Elena
2017-12-01
Isoprene emission from plants subject to a combination of ozone (O 3 ) and nitrogen (N) has never been investigated. Cathay poplar (Populus cathayana) saplings were exposed to O 3 (CF, charcoal-filtered air, NF, non-filtered ambient air and E-O 3 , non-filtered air +40ppb) and N treatments (N0, 0kgNha -1 year -1 , N50, 50kgNha -1 year -1 and N100, 100kgNha -1 year -1 ) for 96days. Increasing O 3 exposure decreased isoprene emission (11.5% in NF and 57.9% in E-O 3 ), as well as light-saturated photosynthetic rate (A sat ) and chlorophyll content, while N load increased isoprene emission (19.6% in N50 and 33.4% in N100) as well as A sat and chlorophyll content. Although O 3 and N interacted significantly in A sat , N did not mitigate the negative effects of O 3 on isoprene emission, i.e. the combined effects were additive and did not interact. These results warrant more research on the combined effects of co-existing global change factors on future isoprene emission and atmospheric chemical processes. Copyright © 2017 Elsevier B.V. All rights reserved.
NASA Astrophysics Data System (ADS)
Loftus, Adrian; Tsay, Si-Chee; Nguyen, Xuan Anh
2016-04-01
droplet size and number concentration, but also the spectral width of the cloud droplet size distribution, the 3M scheme is well suited to simulate aerosol-cloud-precipitation interactions within a three-dimensional regional cloud model. Moreover, the additional variability predicted on the hydrometeor distributions provides beneficial input for forward models to link the simulated microphysical processes with observations as well as to assess both ground-based and satellite retrieval methods. In this presentation, we provide an overview of the 7 South East Asian Studies / Biomass-burning Aerosols and Stratocumulus Environment: Lifecycles and Interactions Experiment (7-SEAS/BASELInE) operations during the spring of 2013. Preliminary analyses of pre-monsoon Sc system lifecycles observed during the first-ever deployment of a ground-based cloud radar to northern Vietnam will be also be presented. Initial results from GCE model simulations of these Sc using double-moment and the new 3M bulk microphysics schemes under various aerosol loadings will be used to showcase the 3M scheme as well as provide insight into how the impact of aerosols on cloud and precipitation processes in stratocumulus over land may manifest themselves in simulated remote-sensing signals. Applications and future work involving ongoing 7-SEAS campaigns aimed at improving our understanding of aerosol-cloud-precipitation interactions of will also be discussed.
Evidence for two-loop interaction from IRIS and SDO observations of penumbral brightenings
NASA Astrophysics Data System (ADS)
Alissandrakis, C. E.; Koukras, A.; Patsourakos, S.; Nindos, A.
2017-07-01
Aims: We investigate small scale energy release events which can provide clues on the heating mechanism of the solar corona. Methods: We analyzed spectral and imaging data from the Interface Region Imaging Spectrograph (IRIS), images from the Atmospheric Imaging Assembly (AIA) aboard the Solar Dynamics Observatoty (SDO), and magnetograms from the Helioseismic and Magnetic Imager (HMI) aboard SDO. Results: We report observations of small flaring loops in the penumbra of a large sunspot on July 19, 2013. Our main event consisted of a loop spanning 15'', from the umbral-penumbral boundary to an opposite polarity region outside the penumbra. It lasted approximately 10 min with a two minute impulsive peak and was observed in all AIA/SDO channels, while the IRIS slit was located near its penumbral footpoint. Mass motions with an apparent velocity of 100 km s-1 were detected beyond the brightening, starting in the rise phase of the impulsive peak; these were apparently associated with a higher-lying loop. We interpret these motions in terms of two-loop interaction. IRIS spectra in both the C II and Si iv lines showed very extended wings, up to about 400 km s-1, first in the blue (upflows) and subsequently in the red wing. In addition to the strong lines, emission was detected in the weak lines of Cl I, O I and C I, as well as in the Mg II triplet lines. Absorption features in the profiles of the C II doublet, the Si iv doublet and the Mg II h and k lines indicate the existence of material with a lower source function between the brightening and the observer. We attribute this absorption to the higher loop and this adds further credibility to the two-loop interaction hypothesis. Tilts were detected in the absorption spectra, as well as in the spectra of Cl I, O I, and C I lines, possibly indicating rotational motions from the untwisting of magnetic flux tubes. Conclusions: We conclude that the absorption features in the C II, Si iv and Mg II profiles originate in a higher
Significance of phytohormones in Siberian larch-bud gall midge interaction
Rida M. Matrenina
1991-01-01
Interrelations of the bud gall midge and the Siberian larch are of scientific and practical interest because of the bud gall midge's role as a plant endoparasite. We know that attack by the gall midge sets off a reaction in the entire plant. Invasion by the insect results in a certain interaction between physiological mechanisms of the insect and the plant which...
NASA Astrophysics Data System (ADS)
Rahman, A.; Kollet, S. J.; Sulis, M.
2013-12-01
In the terrestrial hydrological cycle, the atmosphere and the free groundwater table act as the upper and lower boundary condition, respectively, in the non-linear two-way exchange of mass and energy across the land surface. Identifying and quantifying the interactions among various atmospheric-subsurface-landsurface processes is complicated due to the diverse spatiotemporal scales associated with these processes. In this study, the coupled subsurface-landsurface model ParFlow.CLM was applied over a ~28,000 km2 model domain encompassing the Rur catchment, Germany, to simulate the fluxes of the coupled water and energy cycle. The model was forced by hourly atmospheric data from the COSMO-DE model (numerical weather prediction system of the German Weather Service) over one year. Following a spinup period, the model results were synthesized with observed river discharge, soil moisture, groundwater table depth, temperature, and landsurface energy flux data at different sites in the Rur catchment. It was shown that the model is able to reproduce reasonably the dynamics and also absolute values in observed fluxes and state variables without calibration. The spatiotemporal patterns in simulated water and energy fluxes as well as the interactions were studied using statistical, geostatistical and wavelet transform methods. While spatial patterns in the mass and energy fluxes can be predicted from atmospheric forcing and power law scaling in the transition and winter months, it appears that, in the summer months, the spatial patterns are determined by the spatially correlated variability in groundwater table depth. Continuous wavelet transform techniques were applied to study the variability of the catchment average mass and energy fluxes at varying time scales. From this analysis, the time scales associated with significant interactions among different mass and energy balance components were identified. The memory of precipitation variability in subsurface hydrodynamics
Sgarlata, Carmelo; Raymond, Kenneth N
2016-07-05
The entropic and enthalpic driving forces for encapsulation versus sequential exterior guest binding to the [Ga4L6](12-) supramolecular host in solution are very different, which significantly complicates the determination of these thermodynamic parameters. The simultaneous use of complementary techniques, such as NMR, UV-vis, and isothermal titration calorimetry, enables the disentanglement of such multiple host-guest interactions. Indeed, data collected by each technique measure different components of the host-guest equilibria and together provide a complete picture of the solution thermodynamics. Unfortunately, commercially available programs do not allow for global analysis of different physical observables. We thus resorted to a novel procedure for the simultaneous refinement of multiple parameters (ΔG°, ΔH°, and ΔS°) by treating different observables through a weighted nonlinear least-squares analysis of a constrained model. The refinement procedure is discussed for the multiple binding of the Et4N(+) guest, but it is broadly applicable to the deconvolution of other intricate host-guest equilibria.
The significance of microwave observations for the planets
NASA Astrophysics Data System (ADS)
de Pater, Imke
1991-01-01
A review of radio observations of the giant and terrestrial planets is presented, together with a discussion as to how our understanding of the planets' surfaces, atmospheres and magnetospheres has improved with help of these data. Giant planet atmospheres. The radio spectra and resolved images of the four giant planets are compared. Jupiter and Saturn are very much alike: NH3 gas is depleted compared to what would be expected for a solar nitrogen abundance by a factor of ~5 at P <= 1-2 bar, and enhanced by ~1.5 at P > 2 bar on Jupiter and by 3-4 at P > 4-5 bar on Saturn. Bright bands across the planetary disks imply a latitudinal variation in the precise ammonia abundance. Uranus and Neptune are very different from the former two planets, in that they exhibit a depletion of NH3 gas by about two orders of magnitude over a large altitude range in the atmosphere. Uranus shows a large pole-to-equator gradient in brightness temperature. The loss of NH3 gas in all four planetary atmospheres is most likely due to the formation of NH4SH. This requires the H,S abundance in Jupiter and Saturn to be enhanced by a factor of 6-7 and 10-15 respectively above the solar value, and in Uranus and Neptune by over two orders of magnitude. The NH3 and H2S abundances derived from radio data support the "core-instability" models on planetary formation by Pollack and Bodenheimer [1989]. The latitudinal variation in the NH3 abundance on the planets suggests differences in the location of the NH4SH cloud layers and hence the dynamics of the planets. Jupiter's synchrotron radiation. Radio observations of Jupiter's synchrotron radiation have led to a detailed model of Jupiter's inner magnetosphere with electron distributions. The satellites Thebe and Amalthea cause the electrons to be confined to the magnetic equatorial plane. Energy degradation of the electrons by dust in Jupiter's ring harden the electron spectrum considerably. A "hot spot" in Jupiter's radiation belts can partly be
NASA Astrophysics Data System (ADS)
Edwards, Benjamin R.; Belousov, Alexander; Belousova, Marina; Melnikov, Dmitry
2015-12-01
Observations made during January and April 2013 show that interactions between lava flows and snowpack during the 2012-13 Tolbachik fissure eruption in Kamchatka, Russia, were controlled by different styles of emplacement and flow velocities. `A`a lava flows and sheet lava flows generally moved on top of the snowpack with few immediate signs of interaction besides localized steaming. However, lavas melted through underlying snowpack 1-4 m thick within 12 to 24 h, and melt water flowed episodically from the beneath flows. Pahoehoe lava lobes had lower velocities and locally moved beneath/within the snowpack; even there the snow melting was limited. Snowpack responses were physical, including compressional buckling and doming, and thermal, including partial and complete melting. Maximum lava temperatures were up to 1355 K (1082 °C; type K thermal probes), and maximum measured meltwater temperatures were 335 K (62.7 °C). Theoretical estimates for rates of rapid (e.g., radiative) and slower (conductive) snowmelt are consistent with field observations showing that lava advance was fast enough for `a`a and sheet flows to move on top of the snowpack. At least two styles of physical interactions between lava flows and snowpack observed at Tolbachik have not been previously reported: migration of lava flows beneath the snowpack, and localized phreatomagmatic explosions caused by snowpack failure beneath lava. The distinctive morphologies of sub-snowpack lava flows have a high preservation potential and can be used to document snowpack emplacement during eruptions.
The use of community pharmacies in North West England: an observational study.
Mackridge, Adam J; Stokes, Elizabeth C; Gray, Nicola J
2017-04-01
There are few studies of community pharmacy footfall and activity in the existing literature, especially by direct observation. To describe the characteristics of counter interactions between pharmacy staff and customers. Structured observation of all interactions between pharmacy staff and customers across the weekly opening hours of five pharmacies diverse in location and ownership. Three-quarters (76%) of observed interactions were associated with prescriptions, but a significant minority accessed cognitive services. Dispensing was the primary activity across the diverse range of pharmacies. Reasons for visits are diversifying into advice and services, particularly among younger users. © 2016 Royal Pharmaceutical Society.
ERIC Educational Resources Information Center
Hammer, Rubi; Kloet, Jim; Booth, James R.
2016-01-01
As children start attending school they are more likely to face situations where they have to autonomously learn about novel object categories (e.g. by reading a picture book with descriptions of novel animals). Such autonomous observational category learning (OCL) gradually complements interactive feedback-based category learning (FBCL), where a…
Image enhancement filters significantly improve reading performance for low vision observers
NASA Technical Reports Server (NTRS)
Lawton, T. B.
1992-01-01
As people age, so do their photoreceptors; many photoreceptors in central vision stop functioning when a person reaches their late sixties or early seventies. Low vision observers with losses in central vision, those with age-related maculopathies, were studied. Low vision observers no longer see high spatial frequencies, being unable to resolve fine edge detail. We developed image enhancement filters to compensate for the low vision observer's losses in contrast sensitivity to intermediate and high spatial frequencies. The filters work by boosting the amplitude of the less visible intermediate spatial frequencies. The lower spatial frequencies. These image enhancement filters not only reduce the magnification needed for reading by up to 70 percent, but they also increase the observer's reading speed by 2-4 times. A summary of this research is presented.
Aerosol and Cloud Interaction Observed From High Spectral Resolution Lidar Data
NASA Technical Reports Server (NTRS)
Su, Wenying; Schuster, Gregory L.; Loeb, Norman G.; Rogers, Raymond R.; Ferrare, Richard A.; Hostetler, Chris A.; Hair, Johnathan W.; Obland, Michael D.
2008-01-01
Recent studies utilizing satellite retrievals have shown a strong correlation between aerosol optical depth (AOD) and cloud cover. However, these retrievals from passive sensors are subject to many limitations, including cloud adjacency (or 3D) effects, possible cloud contamination, uncertainty in the AOD retrieval. Some of these limitations do not exist in High Spectral Resolution Lidar (HSRL) observations; for instance, HSRL observations are not a ected by cloud adjacency effects, are less prone to cloud contamination, and offer accurate aerosol property measurements (backscatter coefficient, extinction coefficient, lidar ratio, backscatter Angstrom exponent,and aerosol optical depth) at a neospatial resolution (less than 100 m) in the vicinity of clouds. Hence, the HSRL provides an important dataset for studying aerosol and cloud interaction. In this study, we statistically analyze aircraft-based HSRL profiles according to their distance from the nearest cloud, assuring that all profile comparisons are subject to the same large-scale meteorological conditions. Our results indicate that AODs from HSRL are about 17% higher in the proximity of clouds (approximately 100 m) than far away from clouds (4.5 km), which is much smaller than the reported cloud 3D effect on AOD retrievals. The backscatter and extinction coefficients also systematically increase in the vicinity of clouds, which can be explained by aerosol swelling in the high relative humidity (RH) environment and/or aerosol growth through in cloud processing (albeit not conclusively). On the other hand, we do not observe a systematic trend in lidar ratio; we hypothesize that this is caused by the opposite effects of aerosol swelling and aerosol in-cloud processing on the lidar ratio. Finally, the observed backscatter Angstrom exponent (BAE) does not show a consistent trend because of the complicated relationship between BAE and RH. We demonstrate that BAE should not be used as a surrogate for Angstrom
Social Interactions of Juvenile Brown Boobies at Sea as Observed with Animal-Borne Video Cameras
Yoda, Ken; Murakoshi, Miku; Tsutsui, Kota; Kohno, Hiroyoshi
2011-01-01
While social interactions play a crucial role on the development of young individuals, those of highly mobile juvenile birds in inaccessible environments are difficult to observe. In this study, we deployed miniaturised video recorders on juvenile brown boobies Sula leucogaster, which had been hand-fed beginning a few days after hatching, to examine how social interactions between tagged juveniles and other birds affected their flight and foraging behaviour. Juveniles flew longer with congeners, especially with adult birds, than solitarily. In addition, approximately 40% of foraging occurred close to aggregations of congeners and other species. Young seabirds voluntarily followed other birds, which may directly enhance their foraging success and improve foraging and flying skills during their developmental stage, or both. PMID:21573196
Kotlinska-Lemieszek, Aleksandra; Klepstad, Pål; Haugen, Dagny Faksvåg
2015-01-01
Opioids are the most frequently used drugs to treat pain in cancer patients. In some patients, however, opioids can cause adverse effects and drug-drug interactions. No advice concerning the combination of opioids and other drugs is given in the current European guidelines. To identify studies that report clinically significant drug-drug interactions involving opioids used for pain treatment in adult cancer patients. Systematic review with searches in Embase, MEDLINE, and Cochrane Central Register of Controlled Trials from the start of the databases (Embase from 1980) through January 2014. In addition, reference lists of relevant full-text papers were hand-searched. Of 901 retrieved papers, 112 were considered as potentially eligible. After full-text reading, 17 were included in the final analysis, together with 15 papers identified through hand-searching of reference lists. All of the 32 included publications were case reports or case series. Clinical manifestations of drug-drug interactions involving opioids were grouped as follows: 1) sedation and respiratory depression, 2) other central nervous system symptoms, 3) impairment of pain control and/or opioid withdrawal, and 4) other symptoms. The most common mechanisms eliciting drug-drug interactions were alteration of opioid metabolism by inhibiting the activity of cytochrome P450 3A4 and pharmacodynamic interactions due to the combined effect on opioid, dopaminergic, cholinergic, and serotonergic activity in the central nervous system. Evidence for drug-drug interactions associated with opioids used for pain treatment in cancer patients is very limited. Still, the cases identified in this systematic review give some important suggestions for clinical practice. Physicians prescribing opioids should recognize the risk of drug-drug interactions and if possible avoid polypharmacy.
Cervero, Miguel; Torres, Rafael; Jusdado, Juan José; Pastor, Susana; Agud, Jose Luis
2016-04-15
To determine the prevalence and types of clinically significant drug-drug interactions (CSDI) in the drug regimens of HIV-infected patients receiving antiretroviral treatment. retrospective review of database. Centre: Hospital Universitario Severo Ochoa, Infectious Unit. one hundred and forty-two participants followed by one of the authors were selected from January 1985 to December 2014. from their outpatient medical records we reviewed information from the last available visit of the participants, in relation to HIV infection, comorbidities, demographics and the drugs that they were receiving; both antiretroviral drugs and drugs not related to HIV infection. We defined CSDI from the information sheet and/or database on antiretroviral drug interactions of the University of Liverpool (http://www.hiv-druginteractions.org) and we developed a diagnostic tool to predict the possibility of CSDI. By multivariate logistic regression analysis and by estimating the diagnostic performance curve obtained, we identified a quick tool to predict the existence of drug interactions. Of 142 patients, 39 (29.11%) had some type of CSDI and in 11.2% 2 or more interactions were detected. In only one patient the combination of drugs was contraindicated (this patient was receiving darunavir/r and quetiapine). In multivariate analyses, predictors of CSDI were regimen type (PI or NNRTI) and the use of 3 or more non-antiretroviral drugs (AUC 0.886, 95% CI 0.828 to 0.944; P=.0001). The risk was 18.55 times in those receiving NNRTI and 27,95 times in those receiving IP compared to those taking raltegravir. Drug interactions, including those defined as clinically significant, are common in HIV-infected patients treated with antiretroviral drugs, and the risk is greater in IP-based regimens. Raltegravir-based prescribing, especially in patients who receive at least 3 non-HIV drugs could avoid interactions. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.
NASA Astrophysics Data System (ADS)
Abe, K.; Adam, J.; Aihara, H.; Akiri, T.; Andreopoulos, C.; Aoki, S.; Ariga, A.; Ariga, T.; Assylbekov, S.; Autiero, D.; Barbi, M.; Barker, G. J.; Barr, G.; Bass, M.; Batkiewicz, M.; Bay, F.; Bentham, S. W.; Berardi, V.; Berger, B. E.; Berkman, S.; Bertram, I.; Bhadra, S.; Blaszczyk, F. d. M.; Blondel, A.; Bojechko, C.; Bordoni, S.; Boyd, S. B.; Brailsford, D.; Bravar, A.; Bronner, C.; Buchanan, N.; Calland, R. G.; Caravaca Rodríguez, J.; Cartwright, S. L.; Castillo, R.; Catanesi, M. G.; Cervera, A.; Cherdack, D.; Christodoulou, G.; Clifton, A.; Coleman, J.; Coleman, S. J.; Collazuol, G.; Connolly, K.; Cremonesi, L.; Dabrowska, A.; Danko, I.; Das, R.; Davis, S.; de Perio, P.; De Rosa, G.; Dealtry, T.; Dennis, S. R.; Densham, C.; Dewhurst, D.; Di Lodovico, F.; Di Luise, S.; Drapier, O.; Duboyski, T.; Duffy, K.; Dufour, F.; Dumarchez, J.; Dytman, S.; Dziewiecki, M.; Emery-Schrenk, S.; Ereditato, A.; Escudero, L.; Finch, A. J.; Fiorentini Aguirre, G. A.; Friend, M.; Fujii, Y.; Fukuda, Y.; Furmanski, A. P.; Galymov, V.; Gaudin, A.; Giffin, S.; Giganti, C.; Gilje, K.; Goeldi, D.; Golan, T.; Gomez-Cadenas, J. J.; Gonin, M.; Grant, N.; Gudin, D.; Hadley, D. R.; Haegel, L.; Haesler, A.; Haigh, M. D.; Hamilton, P.; Hansen, D.; Hara, T.; Hartz, M.; Hasegawa, T.; Hastings, N. C.; Hayato, Y.; Hearty, C.; Helmer, R. L.; Hierholzer, M.; Hignight, J.; Hillairet, A.; Himmel, A.; Hiraki, T.; Hirota, S.; Holeczek, J.; Horikawa, S.; Huang, K.; Ichikawa, A. K.; Ieki, K.; Ieva, M.; Ikeda, M.; Imber, J.; Insler, J.; Irvine, T. J.; Ishida, T.; Ishii, T.; Ives, S. J.; Iwai, E.; Iwamoto, K.; Iyogi, K.; Izmaylov, A.; Jacob, A.; Jamieson, B.; Johnson, R. A.; Johnson, S.; Jo, J. H.; Jonsson, P.; Jung, C. K.; Kabirnezhad, M.; Kaboth, A. C.; Kajita, T.; Kakuno, H.; Kameda, J.; Kanazawa, Y.; Karlen, D.; Karpikov, I.; Katori, T.; Kearns, E.; Khabibullin, M.; Khotjantsev, A.; Kielczewska, D.; Kikawa, T.; Kilinski, A.; Kim, J.; King, S.; Kisiel, J.; Kitching, P.; Kobayashi, T.; Koch, L.; Kolaceke, A.; Konaka, A.; Kormos, L. L.; Korzenev, A.; Koseki, K.; Koshio, Y.; Kreslo, I.; Kropp, W.; Kubo, H.; Kudenko, Y.; Kumaratunga, S.; Kurjata, R.; Kutter, T.; Lagoda, J.; Laihem, K.; Lamont, I.; Larkin, E.; Laveder, M.; Lawe, M.; Lazos, M.; Lee, K. P.; Licciardi, C.; Lindner, T.; Lister, C.; Litchfield, R. P.; Longhin, A.; Ludovici, L.; Macaire, M.; Magaletti, L.; Mahn, K.; Malek, M.; Manly, S.; Marino, A. D.; Marteau, J.; Martin, J. F.; Martynenko, S.; Maruyama, T.; Marzec, J.; Mathie, E. L.; Matveev, V.; Mavrokoridis, K.; Mazzucato, E.; McCarthy, M.; McCauley, N.; McFarland, K. S.; McGrew, C.; Mefodiev, A.; Metelko, C.; Mezzetto, M.; Mijakowski, P.; Miller, C. A.; Minamino, A.; Mineev, O.; Mine, S.; Missert, A.; Miura, M.; Monfregola, L.; Moriyama, S.; Mueller, Th. A.; Murakami, A.; Murdoch, M.; Murphy, S.; Myslik, J.; Nagasaki, T.; Nakadaira, T.; Nakahata, M.; Nakai, T.; Nakamura, K.; Nakayama, S.; Nakaya, T.; Nakayoshi, K.; Nantais, C.; Naples, D.; Nielsen, C.; Nirkko, M.; Nishikawa, K.; Nishimura, Y.; Nowak, J.; O'Keeffe, H. M.; Ohta, R.; Okumura, K.; Okusawa, T.; Oryszczak, W.; Oser, S. M.; Ovsyannikova, T.; Owen, R. A.; Oyama, Y.; Palladino, V.; Palomino, J. L.; Paolone, V.; Payne, D.; Pearce, G. F.; Perevozchikov, O.; Perkin, J. D.; Petrov, Y.; Pickard, L.; Pinzon Guerra, E. S.; Pistillo, C.; Plonski, P.; Poplawska, E.; Popov, B.; Posiadala-Zezula, M.; Poutissou, J.-M.; Poutissou, R.; Przewlocki, P.; Quilain, B.; Radicioni, E.; Ratoff, P. N.; Ravonel, M.; Rayner, M. A. M.; Redij, A.; Reeves, M.; Reinherz-Aronis, E.; Riccio, C.; Retiere, F.; Robert, A.; Rodrigues, P. A.; Rojas, P.; Rondio, E.; Roth, S.; Rubbia, A.; Ruterbories, D.; Sacco, R.; Sakashita, K.; Sánchez, F.; Sato, F.; Scantamburlo, E.; Scholberg, K.; Schoppmann, S.; Schwehr, J.; Scott, M.; Seiya, Y.; Sekiguchi, T.; Sekiya, H.; Sgalaberna, D.; Shaker, F.; Shiozawa, M.; Short, S.; Shustrov, Y.; Sinclair, P.; Smith, B.; Smith, R. J.; Smy, M.; Sobczyk, J. T.; Sobel, H.; Sorel, M.; Southwell, L.; Stamoulis, P.; Steinmann, J.; Still, B.; Suda, Y.; Suzuki, A.; Suzuki, K.; Suzuki, S. Y.; Suzuki, Y.; Szeglowski, T.; Tacik, R.; Tada, M.; Takahashi, S.; Takeda, A.; Takeuchi, Y.; Tanaka, H. K.; Tanaka, H. A.; Tanaka, M. M.; Taylor, I. J.; Terhorst, D.; Terri, R.; Thompson, L. F.; Thorley, A.; Tobayama, S.; Toki, W.; Tomura, T.; Totsuka, Y.; Touramanis, C.; Tsukamoto, T.; Tzanov, M.; Uchida, Y.; Ueno, K.; Vacheret, A.; Vagins, M.; Vasseur, G.; Wachala, T.; Waldron, A. V.; Walter, C. W.; Wark, D.; Wascko, M. O.; Weber, A.; Wendell, R.; Wilkes, R. J.; Wilking, M. J.; Wilkinson, C.; Williamson, Z.; Wilson, J. R.; Wilson, R. J.; Wongjirad, T.; Yamada, Y.; Yamamoto, K.; Yanagisawa, C.; Yano, T.; Yen, S.; Yershov, N.; Yokoyama, M.; Yuan, T.; Yu, M.; Zalewska, A.; Zalipska, J.; Zambelli, L.; Zaremba, K.; Ziembicki, M.; Zimmerman, E. D.; Zito, M.; Żmuda, J.; T2K Collaboration
2014-10-01
We report the first measurement of the neutrino-oxygen neutral-current quasielastic (NCQE) cross section. It is obtained by observing nuclear deexcitation γ rays which follow neutrino-oxygen interactions at the Super-Kamiokande water Cherenkov detector. We use T2K data corresponding to 3.01 ×1 020 protons on target. By selecting only events during the T2K beam window and with well-reconstructed vertices in the fiducial volume, the large background rate from natural radioactivity is dramatically reduced. We observe 43 events in the 4-30 MeV reconstructed energy window, compared with an expectation of 51.0, which includes an estimated 16.2 background events. The background is primarily nonquasielastic neutral-current interactions and has only 1.2 events from natural radioactivity. The flux-averaged NCQE cross section we measure is 1.55 ×1 0-38 cm2 with a 68% confidence interval of (1.22 ,2.20 )×1 0-38 cm2 at a median neutrino energy of 630 MeV, compared with the theoretical prediction of 2.01 ×1 0-38 cm2 .
Atomic dark matter with hyperfine interactions
NASA Astrophysics Data System (ADS)
Boddy, Kimberly K.; Kaplinghat, Manoj; Kwa, Anna; Peter, Annika H. G.
2017-11-01
We consider dark matter as an analog of hydrogen in a secluded sector and study its astrophysical implications. The self interactions between dark matter particles include elastic scatterings as well as inelastic processes from hyperfine transitions. We show that for a dark hydrogen mass in the 10-100 GeV range and a dark fine-structure constant larger than 0.01, the self-interaction cross section has the right magnitude and velocity dependence to explain the low dark matter density cores seen in small galaxies while being consistent with all constraints from observations of galaxy clusters. Excitations to the hyperfine state and subsequent decays, however, may cause significant cooling losses and affect the evolution of low-mass halos. We also find minimum halo masses in the range of 103.5-107 M⊙, which are significantly larger than the typical predictions for weakly interacting dark matter models. This pattern of observables in structure formation is unique to this model, making it possible to determine the viability of hidden-sector hydrogen as a dark matter candidate.
Interactions between C and Cu atoms in single-layer graphene: direct observation and modelling.
Kano, Emi; Hashimoto, Ayako; Kaneko, Tomoaki; Tajima, Nobuo; Ohno, Takahisa; Takeguchi, Masaki
2016-01-07
Metal doping into the graphene lattice has been studied recently to develop novel nanoelectronic devices and to gain an understanding of the catalytic activities of metals in nanocarbon structures. Here we report the direct observation of interactions between Cu atoms and single-layer graphene by transmission electron microscopy. We document stable configurations of Cu atoms in the graphene sheet and unique transformations of graphene promoted by Cu atoms. First-principles calculations based on density functional theory reveal a reduction of energy barrier that caused rotation of C-C bonds near Cu atoms. We discuss two driving forces, electron irradiation and in situ heating, and conclude that the observed transformations were mainly promoted by electron irradiation. Our results suggest that individual Cu atoms can promote reconstruction of single-layer graphene.
Observations of Shock Diffusion and Interactions in Supersonic Freestreams with Counterflowing Jets
NASA Technical Reports Server (NTRS)
Daso, Endwell O.; Pritchett, Victor E.; Wang, Ten-See; Blankson, Isiah M.; Auslender, Aaron H.
2006-01-01
One of the technical challenges in long-duration space exploration and interplanetary missions is controlled entry and re-entry into planetary and Earth atmospheres, which requires the dissipation of considerable kinetic energy as the spacecraft decelerates and penetrates the atmosphere. Efficient heat load management of stagnation points and acreage heating remains a technological challenge and poses significant risk, particularly for human missions. An innovative approach using active flow control concept is proposed to significantly modify the external flow field about the spacecraft in planetary atmospheric entry and re-entry in order to mitigate the harsh aerothermal environments, and significantly weaken and disperse the shock-wave system to reduce aerothermal loads and wave drag, as well as improving aerodynamic performance. To explore the potential benefits of this approach, we conducted fundamental experiments in a trisonic blow down wind tunnel to investigate the effects of counterflowing sonic and supersonic jets against supersonic freestreams to gain a better understanding of the flow physics of the interactions of the opposing flows and the resulting shock structure.
Matsumoto, Hideyuki; Hamaguchi, Hirotoshi; Nakayama, Takahiro; Oda, Tetsuya; Ikagawa, Takashi; Imafuku, Ichiro
2008-02-01
On plain brain computed tomography (CT), it is difficult to evaluate stenosis of internal carotid artery (ICA) because ICA is surrounded by structures, even though we can observe calcification of carotid siphon in some patients by using bone condition. However the pathologic significance has not been well known. We studied the pathologic significance of carotid siphon calcification observed on bone condition of brain CT. A total of 112 patients who were diagnosed or suspected as cerebrovascular diseases were registered. We classified the calcification into four levels (none, mild, moderate, severe) based on the degree of calcification. Then we compared it with the degree of stenosis of carotid siphon seen on brain magnetic resonance angiography (MRA) and with max intima-medial thickness (IMT) from common carotid artery (CCA) to ICA on carotid ultrasonography. The mean +/- standard deviation of max IMT to none, mild, moderate and severe in the degree of calcification were 1.03 +/- 0.64 (0.4-2.8), 1.65 +/- 0.83 (0.5-4.1), 2.03 +/- 0.83 (0.8-4.1) and 2.81 +/- 1.15 (0.7-6.5) mm, respectively. The calcification on brain CT significantly correlated with the degree of stenosis on brain MRA and with max IMT on carotid ultrasonography. The calcification of carotid siphon on bone condition of brain CT correlated with stenosis of the same portion and atherosclerosis of CCA bifurcation. Recently, on DICOM viewer, clinicians can convert plain condition into bone condition on brain CT due to popularization of PACS. We should pay attention to calcification of carotid siphon in patients with ischemic cerebrovascular diseases because we can estimate the atherosclerosis of both carotid siphon and CCA bifurcation easily and immediately.
Cengiz, Bülent; Vurallı, Doğa; Zinnuroğlu, Murat; Bayer, Gözde; Golmohammadzadeh, Hassan; Günendi, Zafer; Turgut, Ali Emre; İrfanoğlu, Bülent; Arıkan, Kutluk Bilge
2018-02-01
This study aimed to explore the relationship between action observation (AO)-related corticomotor excitability changes and phases of observed action and to explore the effects of pure AO and concurrent AO and motor imagery (MI) state on corticomotor excitability using TMS. It was also investigated whether the mirror neuron system activity is muscle-specific. Fourteen healthy volunteers were enrolled in the study. EMG recordings were taken from the right first dorsal interosseous and the abductor digiti minimi muscles. There was a significant main effect of TMS timing (after the beginning of the movement, at the beginning of motor output state, and during black screen) on the mean motor evoked potential (MEP) amplitude. Mean MEP amplitudes for AO combined with MI were significantly higher than pure AO session. There was a significant interaction between session and TMS timing. There was no significant main effect of muscle on MEP amplitude. The results indicate that corticomotor excitability is modulated by different phases of the observed motor movement and this modulation is not muscle-specific. Simultaneous MI and AO enhance corticomotor excitability significantly compared to pure AO.
Moon-Magnetosphere Interactions at Saturn: Recent Highlights from Cassini Observations and Modelling
NASA Astrophysics Data System (ADS)
Simon, S.; Kriegel, H.; Saur, J.; Neubauer, F. M.; Wennmacher, A.; Motschmann, U.; Dougherty, M. K.
2012-09-01
Since the arrival of the Cassini spacecraft at Saturn in July 2004, newly collected plasma and magnetic field data have greatly expanded our knowledge on the giant planet's magnetosphere and its multifaceted family of moons. More than 160 orbits around the planet have already been accomplished by Cassini, encompassing 85 close flybys of Saturn's largest satellite Titan as well as 20 encounters of Enceladus. This small icy moon had been identified as the major source of magnetospheric plasma and neutral particles during the first year of Cassini's tour in the Saturnian system. In addition, the spacecraft has paid visits to several of the other icy satellites in the inner and middle magnetosphere: Rhea (3 flybys), Dione (3 flybys) and Tethys (1 flyby). The inner icy satellites and Titan are located within Saturn's magnetosphere for average solar wind conditions, revolving around the giant planet on prograde orbits in its equatorial plane. Since their orbital velocities are clearly exceeded by the speed of the at least partially corotating magnetospheric plasma, the moons are continuously "overtaken" by the magnetospheric flow. Thus, their trailing hemispheres are permanently exposed to a bombardment with thermal magnetospheric plasma. The characteristics of the resulting plasma interaction process depend on the properties of the moon itself as well as on the parameters (density, velocity, temperature, magnetic field strength) of the incident magnetospheric flow and the energetic particle population. In this presentation, we shall review some recent advances in our understanding of the interaction between Saturn's moons and their plasma environment: Enceladus: Electron absorption by submicron dust grains within the plume gives rise to a negative sign of the Hall conductance in Enceladus' plume. The resulting twist of the magnetic field, referred to as the Anti-Hall effect, has been observed during all targeted Enceladus flybys accomplished to date. We present an
NASA Astrophysics Data System (ADS)
Hixson, J.; Ward, A. S.; Schmadel, N.
2015-12-01
The exchange of water and solutes across the stream-hyporheic-riparian-hillslope continuum is controlled by the interaction of dynamic hydrological processes with the underlying geological setting. Our current understanding of exchange processes is primarily based on field observations collected during baseflow conditions, with few studies considering time-variable stream-aquifer interactions during storm events. We completed ten sets of four in-stream tracer slug injections during and after a large storm event in a headwater catchment at the H.J. Andrews Experimental Forest, Oregon. The injections were performed in three adjacent 50-meter study reaches, enabling comparison of spatial heterogeneity in transport processes. Reach-scale data demonstrate apparent trends with discharge in both transient storage and long-term storage (commonly "channel water balance"). Comparison of flowpath-scale observations from a network of monitoring wells to reach-scale observations showed that the advective timescale changed with discharge making it difficult to infer process from simple, reach-scale tracer studies. Overall, our results highlight the opportunities and challenges for interpretation of multi-scale solute tracer data along the stream-hyporheic-riparian-hillslope continuum.
Karlsson, Torgny; Ek, Weronica E.
2017-01-01
Previous genome-wide association studies (GWAS) have identified hundreds of genetic loci to be associated with body mass index (BMI) and risk of obesity. Genetic effects can differ between individuals depending on lifestyle or environmental factors due to gene-environment interactions. In this study, we examine gene-environment interactions in 362,496 unrelated participants with Caucasian ancestry from the UK Biobank resource. A total of 94 BMI-associated SNPs, selected from a previous GWAS on BMI, were used to construct weighted genetic scores for BMI (GSBMI). Linear regression modeling was used to estimate the effect of gene-environment interactions on BMI for 131 lifestyle factors related to: dietary habits, smoking and alcohol consumption, physical activity, socioeconomic status, mental health, sleeping patterns, as well as female-specific factors such as menopause and childbirth. In total, 15 lifestyle factors were observed to interact with GSBMI, of which alcohol intake frequency, usual walking pace, and Townsend deprivation index, a measure of socioeconomic status, were all highly significant (p = 1.45*10−29, p = 3.83*10−26, p = 4.66*10−11, respectively). Interestingly, the frequency of alcohol consumption, rather than the total weekly amount resulted in a significant interaction. The FTO locus was the strongest single locus interacting with any of the lifestyle factors. However, 13 significant interactions were also observed after omitting the FTO locus from the genetic score. Our analyses indicate that many lifestyle factors modify the genetic effects on BMI with some groups of individuals having more than double the effect of the genetic score. However, the underlying causal mechanisms of gene-environmental interactions are difficult to deduce from cross-sectional data alone and controlled experiments are required to fully characterise the causal factors. PMID:28873402
Myezwa, Hellen; Hanass-Hancock, Jill; Pautz, Nikolas
2018-06-20
The average lifespan of people with human immunodeficiency virus (HIV) has increased because of the enhanced access to anti-retroviral treatment. This increased longevity has led to a heightened focus on the comorbidities which may arise, allowing a clearer understanding of the contextual, personal, psychological and functional problems and their interrelations. Disability (functional limitations) and insufficient nutritional intake may interact cyclically with HIV and/or acquired immunodeficiency syndrome (AIDS); however, no research to date has investigated this interaction. Aims: The objective of this article was to report on the nutritional outcomes using albumin and body mass index outcomes as a subset of a larger study among adults living with HIV and/or AIDS. Setting: This study was conducted at a large HIV clinic based in an urban area in Johannesburg, South Africa, which provides HIV treatment and support to over 6000 persons with HIV and TB. This clinic is part of a large public health regional hospital where extensive HIV research is undertaken. Methods: This study was a cross-sectional observational study. The sample composed of 278 participants between 18 and 65 years of age and had been on highly active antiretroviral therapy (HAART) for more than six months. Statistical analyses were performed using the Statistical Package for the Social Sciences. Results: The results indicated that albumin level had significant inverse associations with functional limitations and physical health symptoms. Women were significantly more likely to have lower nutritional levels. A logistic regression analysis suggested that gender and physical health symptoms were the primary predictors of albumin levels. Conclusion: The findings presented in this article can be applied to HIV and/or AIDS treatment programmes, such as HAART. It re-emphasises the importance of providing individuals on anti-retroviral therapy with affordable and adequate nutrition, education on the
Plis, Sergey M; Sui, Jing; Lane, Terran; Roy, Sushmita; Clark, Vincent P; Potluru, Vamsi K; Huster, Rene J; Michael, Andrew; Sponheim, Scott R; Weisend, Michael P; Calhoun, Vince D
2013-01-01
Identifying the complex activity relationships present in rich, modern neuroimaging data sets remains a key challenge for neuroscience. The problem is hard because (a) the underlying spatial and temporal networks may be nonlinear and multivariate and (b) the observed data may be driven by numerous latent factors. Further, modern experiments often produce data sets containing multiple stimulus contexts or tasks processed by the same subjects. Fusing such multi-session data sets may reveal additional structure, but raises further statistical challenges. We present a novel analysis method for extracting complex activity networks from such multifaceted imaging data sets. Compared to previous methods, we choose a new point in the trade-off space, sacrificing detailed generative probability models and explicit latent variable inference in order to achieve robust estimation of multivariate, nonlinear group factors (“network clusters”). We apply our method to identify relationships of task-specific intrinsic networks in schizophrenia patients and control subjects from a large fMRI study. After identifying network-clusters characterized by within- and between-task interactions, we find significant differences between patient and control groups in interaction strength among networks. Our results are consistent with known findings of brain regions exhibiting deviations in schizophrenic patients. However, we also find high-order, nonlinear interactions that discriminate groups but that are not detected by linear, pair-wise methods. We additionally identify high-order relationships that provide new insights into schizophrenia but that have not been found by traditional univariate or second-order methods. Overall, our approach can identify key relationships that are missed by existing analysis methods, without losing the ability to find relationships that are known to be important. PMID:23876245
DOE Office of Scientific and Technical Information (OSTI.GOV)
Shen Yuandeng; Liu Yu; Zhao Ruijuan
2013-08-20
We present observations of the diffraction, refraction, and reflection of a global extreme-ultraviolet (EUV) wave propagating in the solar corona. These intriguing phenomena are observed when the wave interacts with two remote active regions, and together they exhibit properties of an EUV wave. When the wave approached AR11465, it became weaker and finally disappeared in the active region, but a few minutes later a new wavefront appeared behind the active region, and it was not concentric with the incoming wave. In addition, a reflected wave was also simultaneously observed on the wave incoming side. When the wave approached AR11459, itmore » transmitted through the active region directly and without reflection. The formation of the new wavefront and the transmission could be explained with diffraction and refraction effects, respectively. We propose that the different behaviors observed during the interactions may be caused by different speed gradients at the boundaries of the two active regions. We find that the EUV wave formed ahead of a group of expanding loops a few minutes after the start of the loops' expansion, which represents the initiation of the associated coronal mass ejection (CME). Based on these results, we conclude that the EUV wave should be a nonlinear magnetosonic wave or shock driven by the associated CME, which propagated faster than the ambient fast mode speed and gradually slowed down to an ordinary linear wave. Our observations support the hybrid model that includes both fast wave and slow non-wave components.« less
ERIC Educational Resources Information Center
Reese-Weber, Marla
2008-01-01
The present study provides experimental data comparing emerging adults' attitudes toward dating and sibling violence in adolescence using a new methodology in which participants observe a violent interaction between adolescents. The reported amount of violence experienced in dating and sibling relationships among emerging adults is also compared.…
Social interaction, languaging and the operational conditions for the emergence of observing.
Raimondi, Vincenzo
2014-01-01
In order to adequately understand the foundations of human social interaction, we need to provide an explanation of our specific mode of living based on linguistic activity and the cultural practices with which it is interwoven. To this end, we need to make explicit the constitutive conditions for the emergence of the phenomena which relate to language and joint activity starting from their operational-relational matrix. The approach presented here challenges the inadequacy of mentalist models to explain the relation between language and interaction. Recent empirical studies concerning joint attention and language acquisition have led scholars such as Tomasello et al. (2005) to postulate the existence of a universal human "sociocognitive infrastructure" that drives joint social activities and is biologically inherited. This infrastructure would include the skill of precocious intention-reading, and is meant to explain human linguistic development and cultural learning. However, the cognitivist and functionalist assumptions on which this model relies have resulted in controversial hypotheses (i.e., intention-reading as the ontogenetic precursor of language) which take a contentious conception of mind and language for granted. By challenging this model, I will show that we should instead turn ourselves towards a constitutive explanation of language within a "bio-logical" understanding of interactivity. This is possible only by abandoning the cognitivist conception of organism and traditional views of language. An epistemological shift must therefore be proposed, based on embodied, enactive and distributed approaches, and on Maturana's work in particular. The notions of languaging and observing that will be discussed in this article will allow for a bio-logically grounded, theoretically parsimonious alternative to mentalist and spectatorial approaches, and will guide us towards a wider understanding of our sociocultural mode of living.
Social interaction, languaging and the operational conditions for the emergence of observing
Raimondi, Vincenzo
2014-01-01
In order to adequately understand the foundations of human social interaction, we need to provide an explanation of our specific mode of living based on linguistic activity and the cultural practices with which it is interwoven. To this end, we need to make explicit the constitutive conditions for the emergence of the phenomena which relate to language and joint activity starting from their operational-relational matrix. The approach presented here challenges the inadequacy of mentalist models to explain the relation between language and interaction. Recent empirical studies concerning joint attention and language acquisition have led scholars such as Tomasello et al. (2005) to postulate the existence of a universal human “sociocognitive infrastructure” that drives joint social activities and is biologically inherited. This infrastructure would include the skill of precocious intention-reading, and is meant to explain human linguistic development and cultural learning. However, the cognitivist and functionalist assumptions on which this model relies have resulted in controversial hypotheses (i.e., intention-reading as the ontogenetic precursor of language) which take a contentious conception of mind and language for granted. By challenging this model, I will show that we should instead turn ourselves towards a constitutive explanation of language within a “bio-logical” understanding of interactivity. This is possible only by abandoning the cognitivist conception of organism and traditional views of language. An epistemological shift must therefore be proposed, based on embodied, enactive and distributed approaches, and on Maturana’s work in particular. The notions of languaging and observing that will be discussed in this article will allow for a bio-logically grounded, theoretically parsimonious alternative to mentalist and spectatorial approaches, and will guide us towards a wider understanding of our sociocultural mode of living. PMID:25177308
Tonge, Karen L; Jones, Rachel A; Hagenbuchner, Markus; Nguyen, Tuc V; Okely, Anthony D
2017-02-07
The benefits of regular physical activity for children are significant. Previous research has addressed the quantity and quality of children's physical activity while in early childhood education and care (ECEC) settings, yet little research has investigated the social and physical environmental influences on physical activity in these settings. The outcomes of this study will be to measure these social and physical environmental influences on children's physical activity using a combination of a real-time location system (RTLS) (a closed system that tracks the location of movement of participants via readers and tags), accelerometry and direct observation. This study is the first of its kind to combine RTLSs and accelerometer data in ECEC settings. It is a cross-sectional study involving ∼100 educators and 500 children from 11 ECEC settings in the Illawarra region of New South Wales, Australia. A RTLS and Actigraph GT3X+ accelerometers will be concurrently used to measure the level and location of the children's and educators' physical activity while in outside environments. Children and educators will wear accelerometers on their hip that record triaxial acceleration data at 100 Hz. Children and educators will also wear a tag watch on their wrist that transmits a signal to anchors of the RTLS and the triangulation of signals will identify their specific location. In addition to these, up to three random periods (10-25 min in length) will be used to collect observational data each day and assessed with the classroom assessment and scoring system to measure the quality of interactions. In conjunction with the real-time location system (RTLS) and accelerometers, these observations will measure the relationship between the quality of interactions and children's physical activity. The results of this study will be disseminated through peer-reviewed publications and presentations. Ethical approval was obtained through the University of Wollongong Human Research
Observations of interactions between interplanetary and geomagnetic fields
NASA Technical Reports Server (NTRS)
Burch, J. L.
1973-01-01
Magnetospheric effects associated with variations of the north-south component of the interplanetary magnetic field are examined in light of recent recent experimental and theoretical results. Although the occurrence of magnetospheric substorms is statistically related to periods of southward interplanetary magnetic field, the details of the interaction are not understood. In particular, attempts to separate effects resulting directly from the interaction between the interplanetary and geomagnetic fields from those associated with substorms have produced conflicting results. The transfer of magnetic flux from the dayside to the nightside magnetosphere is evidenced by equatorward motion of the polar cusp and increases of the magnetic energy density in the lobes of the geomagnetic tail. The formation of a macroscopic X-type neutral line at tail distances less than 35 R sub E appears to be a substorm phenomenon.
NASA Astrophysics Data System (ADS)
Li, Yaohui
2017-04-01
Drought is one of the most common and frequent nature disasters in the world, particularly in China under the continental monsoonal climate with great variation. About thirty percent of economic loss caused by natural disasters is contributed by droughts in China, which is by far the most damaging weather disasters because of its long duration and extensive hazard areas. Droughts not only have a serious impact on the agriculture, water resources, ecology, natural environment, but also seriously affect the socio-economic such as human health, energy and transportation. Worsely, under the background of climate change, droughts in show increases in frequency, duration and scope in many places around the world, particularly northern China. Nowadays, droughts have aroused extensive concern of the scientists, governments and international community, and became one of the important scientific issues in geoscience research. However, most of researches on droughts in China so far were focused on the causes or regulars of one type of droughts (the atmosphere, agriculture or hydrological) from the perspective of the atmospheric circulation anomalies. Few of them considered a whole cycle of the drought-forming process from atmosphere-land interaction to agricultural/ecological one in terms of the land-atmosphere interaction; meanwhile, the feedback mechanism with the drought and land-atmosphere interaction is still unclear as well. All of them is because of lack of the relevant comprehensive observation experiment. "Land-atmosphere interaction and disaster-causing process of drought in northern China: observation and experiment" (DroughtPEX_China)is just launched in this requirement and background. DroughtPEX_China is supported by Special Scientific Research Fund of Public Welfare Industry (Meteorological) of China (Grant No.GYHY201506001)—"Drought Meteorology Scientific Research Project—the disaster-causing process and mechanism of drought in northern China". This project
Voicu, Victor; Sârbu, Costel; Tache, Florentin; Micăle, Florina; Rădulescu, Ştefan Flavian; Sakurada, Koichi; Ohta, Hikoto; Medvedovici, Andrei
2014-05-01
The liquid chromatographic behavior observed under bimodal retention conditions (reversed phase and hydrophilic interaction) offers a new basis for the determination of some derived lipophilicity indices. The experiments were carried out on a representative group (30 compounds) of pyridinium oximes, therapeutically tested in acetylcholinesterase reactivation, covering a large range of lipophilic character. The chromatographic behavior was observed on a mixed mode acting stationary phase, resulting from covalent functionalization of high purity spherical silica with long chain alkyl groups terminated by a polar environment created through the vicinal diol substitution at the lasting carbon atoms (Acclaim Mixed Mode HILIC 1 column). Elution was achieved by combining different proportions of 5 mM ammonium formiate solutions in water and acetonitrile. The derived lipophilicity indices were compared with logP values resulting from different computational algorithms. The correlations between experimental and computed data sets are significant. To obtain a better insight on the transition from reversed phase to hydrophilic interaction retention mechanisms, the variation of the thermodynamic parameters determined through the van׳t Hoff approach was also discussed. Copyright © 2014 Elsevier B.V. All rights reserved.
Muon and neutron observations in connection with the corotating interaction regions
NASA Astrophysics Data System (ADS)
da Silva, M. R.; Dal Lago, A.; Echer, E.; de Lucas, A.; Gonzalez, W. D.; Schuch, N. J.; Munakata, K.; Vieira, L. E. A.; Guarnieri, F. L.
Ground cosmic ray observations are used for studying several kinds of interplanetary structures. The cosmic ray data has different responses to each kind of interplanetary structure. This article has as objective to study cosmic ray muon and neutron signatures due to the passage of corotating interaction region (CIR) in the interplanetary medium, and identify the signatures in the cosmic ray data due to these events. The cosmic ray muon data used in this work are recorded by the multidirectional muon detector installed at INPE’s Observatório Espacial do Sul OES/CRSPE/INPE-MCT, in São Martinho da Serra, RS (Brazil) and the neutron data was recorded by the neutron monitor installed in Newark (USA). The CIR events were selected in the period from 2001 to 2004. CIRs clearly affect cosmic ray density in the interplanetary medium in the Earth’s vicinity, where the magnetic field plays an important role.
Galaxy interactions in the Hickson Compact Group 88
NASA Astrophysics Data System (ADS)
Brosch, Noah
2015-12-01
I present observations of the Hickson Compact Group 88 (HCG88) obtained during the commissioning of a new 28-inch telescope at the Wise Observatory. This galaxy group was advertized to be non-interacting, or to be in a very early interaction stage, but this is not the case. The observations reported here were done using a `luminance' filter, essentially a very broad R filter, reaching a low surface brightness level of ≈26 mag arcsec-2. Additional observations were obtained in a narrow spectral band approximately centred on the rest-frame H α line from the group. Contrary to previous studies, my observations show that at least two of the major galaxies have had significant interactions in the past, although probably not between themselves. I report the discovery of a faint extended tail emerging from the brightest of the group galaxies, severe isophote twisting and possible outer shells around another galaxy, and map the H II regions in all the galaxies.
Datta, Rakesh; Datta, Karuna; Venkatesh, M D
2015-07-01
The classical didactic lecture has been the cornerstone of the theoretical undergraduate medical education. Their efficacy however reduces due to reduced interaction and short attention span of the students. It is hypothesized that the interactive response pad obviates some of these drawbacks. The aim of this study was to evaluate the effectiveness of an interactive response system by comparing it with conventional classroom teaching. A prospective comparative longitudinal study was conducted on 192 students who were exposed to either conventional or interactive teaching over 20 classes. Pre-test, Post-test and retentions test (post 8-12 weeks) scores were collated and statistically analysed. An independent observer measured number of student interactions in each class. Pre-test scores from both groups were similar (p = 0.71). There was significant improvement in both post test scores when compared to pre-test scores in either method (p < 0.001). The interactive post-test score was better than conventional post test score (p < 0.001) by 8-10% (95% CI-difference of means - 8.2%-9.24%-10.3%). The interactive retention test score was better than conventional retention test score (p < 0.001) by 15-18% (95% CI-difference of means - 15.0%-16.64%-18.2%). There were 51 participative events in the interactive group vs 25 in the conventional group. The Interactive Response Pad method was efficacious in teaching. Students taught with the interactive method were likely to score 8-10% higher (statistically significant) in the immediate post class time and 15-18% higher (statistically significant) after 8-12 weeks. The number of student-teacher interactions increases when using the interactive response pads.
NASA Technical Reports Server (NTRS)
Wen, Guoyong; Marshak, Alexander; Cahalan, Robert F.; Remer, Lorraine A.; Kleidman, Richard G.
2007-01-01
3D aerosol-cloud interaction is examined by analyzing two images containing cumulus clouds in biomass burning regions in Brazil. The research consists of two parts. The first part focuses on identifying 3D clo ud impacts on the reflectance of pixel selected for the MODIS aerosol retrieval based purely on observations. The second part of the resea rch combines the observations with radiative transfer computations to identify key parameters in 3D aerosol-cloud interaction. We found that 3D cloud-induced enhancement depends on optical properties of nearb y clouds as well as wavelength. The enhancement is too large to be ig nored. Associated biased error in 1D aerosol optical thickness retrie val ranges from 50% to 140% depending on wavelength and optical prope rties of nearby clouds as well as aerosol optical thickness. We caution the community to be prudent when applying 1D approximations in comp uting solar radiation in dear regions adjacent to clouds or when usin g traditional retrieved aerosol optical thickness in aerosol indirect effect research.
FAR-ULTRAVIOLET OBSERVATIONS OF THE SPICA NEBULA AND THE INTERACTION ZONE
DOE Office of Scientific and Technical Information (OSTI.GOV)
Choi, Yeon-Ju; Min, Kyoung-Wook; Lim, Tae-Ho
2013-09-01
We report the analysis results of far-ultraviolet (FUV) observations, made for a broad region around {alpha} Vir (Spica) including the interaction zone of Loop I and the Local Bubble. The whole region was optically thin and a general correlation was seen between the FUV continuum intensity and the dust extinction, except in the neighborhood of the bright central star, indicating the dust scattering nature of the FUV continuum. We performed Monte Carlo radiative transfer simulations to obtain the optical parameters related to the dust scattering as well as to the geometrical structure of the region. The albedo and asymmetry factormore » were found to be 0.38 {+-} 0.06 and 0.46 {+-} 0.06, respectively, in good agreement with the Milky Way dust grain models. The distance to and the thickness of the interaction zone were estimated to be 70{sup +4}{sub -8} pc and 40{sup +8}{sub -10} pc, respectively. The diffuse FUV continuum in the northern region above Spica was mostly the result of scattering of the starlight from Spica, while that in the southern region was mainly due to the background stars. The C IV {lambda}{lambda}1548, 1551 emission was found throughout the whole region, in contrast to the Si II* {lambda}1532 emission which was bright only within the H II region. This indicates that the C IV line arises mostly at the shell boundaries of the bubbles, with a larger portion likely from the Loop I than from the Local Bubble side, whereas the Si II* line is from the photoionized Spica Nebula.« less
APIS : an interactive database of HST-UV observations of the outer planets
NASA Astrophysics Data System (ADS)
Lamy, Laurent; Henry, Florence; Prangé, Renée; Le Sidaner, Pierre
2014-05-01
Remote UV measurement of the outer planets offer a wealth of informations on rings, moons, planetary atmospheres and magnetospheres. Auroral emissions in particular provide highly valuable constraints on the auroral processes at work and the underlying coupling between the solar wind, the magnetosphere, the ionosphere and the moons. Key observables provided by high resolution spectro-imaging include the spatial topology and the dynamics of active magnetic field lines, the radiated and the precipitated powers or the energy of precipitating particles. The Hubble Space Telescope (HST) acquired thousands of Far-UV spectra and images of the aurorae of Jupiter, Saturn and Uranus since 1993, feeding in numerous magnetospheric studies. But their use remains generally limited, owing to the difficulty to access and use raw and value-added data. APIS, the egyptian god of fertilization, is also the acronym of a new database (Auroral Planetary Imaging and Spectroscopy), aimed at facilitating the use of HST planetary auroral observations. APIS is based at the Virtual Observatory (VO) of Paris and provides a free and interactive access to a variety of high level data through a simple research interface and standard VO tools (as Aladin, Specview). We will present the capabilities of APIS and illustrate them with several examples.
APIS : an interactive database of HST-UV observations of the outer planets
NASA Astrophysics Data System (ADS)
Lamy, L.; Henry, F.; Prangé, R.; Le Sidaner, P.
2013-09-01
Remote UV measurement of the outer planets are a wealth of informations on rings, moons, planetary atmospheres and magnetospheres. Auroral emissions in particular provide highly valuable constraints on the auroral processes at work and the underlying coupling between the solar wind, the magnetosphere, the ionosphere and the moons. Key observables provided by high resolution spectro-imaging include the spatial topology and the dynamics of active magnetic field lines, the radiated and the precipitated powers or the energy of precipitating particles. The Hubble Space Telescope (HST) acquired thousands of Far-UV spectra and images of the aurorae of Jupiter, Saturn and Uranus since 1993, feeding in numerous magnetospheric studies. But their use remains generally limited, owing to the difficulty to access and use raw and value-added data. APIS, the egyptian god of fertilization, is also the acronym of a new database (Auroral Planetary Imaging and Spectroscopy, Figure 1), aimed at facilitating the use of HST planetary auroral observations. APIS is based at the Virtual Observatory (VO) of Paris and provides a free and interactive access to a variety of high level data through a simple research interface and standard VO tools. We will present the capabilities of APIS and illustrate them with several examples.
Observations of wave-particle interactions in the flux pile-up region of asymmetric reconnection
NASA Astrophysics Data System (ADS)
Argall, M. R.; Paulson, K. W.; Ahmadi, N.; Matsui, H.; Torbert, R. B.; Alm, L.; Le Contel, O.; Khotyaintsev, Y. V.; Wilder, F. D.; Turner, D. L.; Strangeway, R. J.; Schwartz, S. J.; Magnes, W.; Giles, B. L.; Lindqvist, P. A.; Ergun, R.; Mauk, B.; Leonard, T. W.
2017-12-01
Recent observations have shown electron energization to >100keV with simultaneous whistler wave activity in the vicinity of the dayside reconnection site. We investigate one possible mechanism for producing these energetic particles. Counter-streaming electrons from the magnetosphere enter the diffusion region and are scattered to all pitch angles (PAs) by strong field-line curvature. As the electrons flow outward into the exhaust, they remagnetize and are focused toward 90° at mirror points within the flux pile-up region. This effect, combined with heating mechanisms in the EDR, produces a temperature anisotropy, while the weak magnetic field lowers the resonant energy into the bulk energy of the plasma. In the end, whistler waves are produced near 100Hz with a wave normal angle of 20°. Simultaneous with the waves, the Electron Drift Instrument observes particle flux modulations of 0° and 180° PA, 500 eV electrons. Multi-spacecraft analysis and Liouville mapping techniques allow us to determine the parallel wave current, potential, and associated energy dissipation. Bursts of 100keV electrons are observed and may interact with the whistler waves.
Using observations to evaluate biosphere-atmosphere interactions in models
NASA Astrophysics Data System (ADS)
Green, Julia; Konings, Alexandra G.; Alemohammad, Seyed H.; Gentine, Pierre
2017-04-01
Biosphere-atmosphere interactions influence the hydrologic cycle by altering climate and weather patterns (Charney, 1975; Koster et al., 2006; Seneviratne et al., 2006), contributing up to 30% of precipitation and radiation variability in certain regions (Green et al., 2017). They have been shown to contribute to the persistence of drought in Europe (Seneviratne et al., 2006), as well as to increase rainfall in the Amazon (Spracklen et al., 2012). Thus, a true representation of these feedbacks in Earth System Models (ESMs) is crucial for accurate forecasting and planning. However, it has been difficult to validate the performance of ESMs since often-times surface and atmospheric flux data are scarce and/or difficult to observe. In this study, we use the results of a new global observational study (using remotely sensed solar-induced fluorescence to represent the biosphere flux) (Green et al., 2017) to determine how well a suite of 13 ESMs capture biosphere-atmosphere feedbacks. We perform a Conditional Multivariate Granger Causality analysis in the frequency domain with radiation, precipitation and temperature as atmospheric inputs and GPP as the biospheric input. Performing the analysis in the frequency domain allows for separation of feedbacks at different time-scales (subseasonal, seasonal or interannual). Our findings can be used to determine whether there is agreement between models, as well as, to pinpoint regions or time-scales of model bias or inaccuracy, which will provide insight on potential improvement. We demonstrate that in addition to the well-known problem of convective parameterization over land in models, the main issue in representing feedbacks between the land and the atmosphere is due to the misrepresentation of water stress. These results provide a direct quantitative assessment of feedbacks in models and how to improve them. References: Charney, J.G. Dynamics of deserts and drought in the Sahel. Quarterly Journal of the Royal Meteorological
Zha, Shanjie; Liu, Saixi; Su, Wenhao; Shi, Wei; Xiao, Guoqiang; Yan, Maocang; Liu, Guangxu
2017-12-01
It has been suggested that climate change may promote the outbreaks of diseases in the sea through altering the host susceptibility, the pathogen virulence, and the host-pathogen interaction. However, the impacts of ocean acidification (OA) on the pathogen components of bacterial community and the host-pathogen interaction of marine bivalves are still poorly understood. Therefore, 16S rRNA high-throughput sequencing and host-pathogen interaction analysis between blood clam (Tegillarca granosa) and Vibrio harveyi were conducted in the present study to gain a better understanding of the ecological impacts of ocean acidification. The results obtained revealed a significant impact of ocean acidification on the composition of microbial community at laboratory scale. Notably, the abundance of Vibrio, a major group of pathogens to many marine organisms, was significantly increased under ocean acidification condition. In addition, the survival rate and haemolytic activity of V. harveyi were significantly higher in the presence of haemolymph of OA treated T. granosa, indicating a compromised immunity of the clam and enhanced virulence of V. harveyi under future ocean acidification scenarios. Conclusively, the results obtained in this study suggest that future ocean acidification may increase the risk of Vibrio pathogen infection for marine bivalve species, such as blood clams. Copyright © 2017 Elsevier Ltd. All rights reserved.
Liljedahl, Matilda; Björck, Erik; Kalén, Susanne; Ponzer, Sari; Bolander Laksov, Klara
2016-08-05
Belongingness has been argued to be a prerequisite for students' learning in the clinical setting but making students feel like they belong to the workplace is a challenge. From a sociocultural perspective, workplace participatory practices is a framework that views clinical learning environments to be created in interaction between students and the workplace and hence, are dependent on them both. The aim of this study was to explore the interdependence between affordances and engagement in clinical learning environments. The research question was: How are nursing students influenced in their interactions with clinical learning environments? An observational study with field observations and follow-up interviews was performed. The study setting comprised three academic teaching hospitals. Field observations included shadowing undergraduate nursing students during entire shifts. Fifty-five hours of field observations and ten follow-up interviews with students, supervisors and clinical managers formed the study data. A thematic approach to the analysis was taken and performed iteratively with the data collection. The results revealed that students strived to fill out the role they were offered in an aspirational way but that they became overwhelmed when given the responsibility of care. When students' basic values did not align with those enacted by the workplace, they were not willing to compromise their own values. Workplaces succeeded in inviting students into the community of nurses and the practice of care. Students demonstrated hesitance regarding their desire to belong to the workplace community. The results imply that the challenge for clinical education is not to increase the experience of belongingness but to maintain students' critical and reflective approach to health care practice. Additionally, results suggest students to be included as an important stakeholder in creating clinical learning environments rather than being viewed as consumer of clinical
Deschrijver, Eliane; Wiersema, Jan R; Brass, Marcel
2016-07-01
Action observation leads to a representation of both the motor aspect of an observed action (motor simulation) and its somatosensory consequences (action-based somatosensory simulation) in the observer's brain. In the current electroencephalography-study, we investigated the neuronal interplay of action-based somatosensory simulation and felt touch. We presented index or middle finger tapping movements of a human or a wooden hand, while simultaneously presenting 'tap-like' tactile sensations to either the corresponding or non-corresponding fingertip of the participant. We focused on an early stage of somatosensory processing [P50, N100 and N140 sensory evoked potentials (SEPs)] and on a later stage of higher-order processing (P3-complex). The results revealed an interaction effect of animacy and congruency in the early P50 SEP and an animacy effect in the N100/N140 SEPs. In the P3-complex, we found an interaction effect indicating that the influence of congruency was larger in the human than in the wooden hand. We argue that the P3-complex may reflect higher-order self-other distinction by signaling simulated action-based touch that does not match own tactile information. As such, the action-based somatosensory congruency paradigm might help understand higher-order social processes from a somatosensory point of view. © The Author (2015). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.
Direct Observation Of Nanoparticle-Surfactant Interactions Using Small Angle Neutron Scattering
NASA Astrophysics Data System (ADS)
Kumar, Sugam; Aswal, V. K.
2010-12-01
Interactions of anionic silica nanoparticles with anionic, cationic and nonionic surfactants have directly been studied by contrast variation small angle neutron scattering (SANS). The measurements are performed on 1 wt% of both silica nanoparticles and surfactants of anionic sodium dodecyle sulphate (SDS), cationic dodecyltrimethyl ammonium bromide (DTAB) and non-ionic polyoxyethylene 10 lauryl ether (C12E10) in aqueous solution. We show that there is no direct interaction in the case of SDS with silica particles, whereas strong interaction for DTAB leads to the aggregation of silica particles. The interaction of C12E10 is found through the micelles adsorbed on the silica particles.
Paya, Alexander M; Silverberg, Jesse L; Padgett, Jennifer; Bauerle, Taryn L
2015-01-01
Research in the field of plant biology has recently demonstrated that inter- and intra-specific interactions belowground can dramatically alter root growth. Our aim was to answer questions related to the effect of inter- vs. intra-specific interactions on the growth and utilization of undisturbed space by fine roots within three dimensions (3D) using micro X-ray computed tomography. To achieve this, Populus tremuloides (quaking aspen) and Picea mariana (black spruce) seedlings were planted into containers as either solitary individuals, or inter-/intra-specific pairs, allowed to grow for 2 months, and 3D metrics developed in order to quantify their use of belowground space. In both aspen and spruce, inter-specific root interactions produced a shift in the vertical distribution of the root system volume, and deepened the average position of root tips when compared to intra-specifically growing seedlings. Inter-specific interactions also increased the minimum distance between root tips belonging to the same root system. There was no effect of belowground interactions on the radial distribution of roots, or the directionality of lateral root growth for either species. In conclusion, we found that significant differences were observed more often when comparing controls (solitary individuals) and paired seedlings (inter- or intra-specific), than when comparing inter- and intra-specifically growing seedlings. This would indicate that competition between neighboring seedlings was more responsible for shifting fine root growth in both species than was neighbor identity. However, significant inter- vs. intra-specific differences were observed, which further emphasizes the importance of biological interactions in competition studies.
The Role of Cognitive and Affective Empathy in Spouses' Support Interactions: An Observational Study
Verhofstadt, Lesley; Devoldre, Inge; Buysse, Ann; Stevens, Michael; Hinnekens, Céline; Ickes, William; Davis, Mark
2016-01-01
The present study examined how support providers’ empathic dispositions (dispositional perspective taking, empathic concern, and personal distress) as well as their situational empathic reactions (interaction-based perspective taking, empathic concern, and personal distress) relate to the provision of spousal support during observed support interactions. Forty-five committed couples provided questionnaire data and participated in two ten-minute social support interactions designed to assess behaviors when partners are offering and soliciting social support. A video-review task was used to assess situational forms of perspective taking (e.g., empathic accuracy), empathic concern and personal distress. Data were analyzed by means of the multi-level Actor-Partner Interdependence Model. Results revealed that providers scoring higher on affective empathy (i.e., dispositional empathic concern), provided lower levels of negative support. In addition, for male partners, scoring higher on cognitive empathy (i.e., situational perspective taking) was related to lower levels of negative support provision. For both partners, higher scores on cognitive empathy (i.e., situational perspective taking) correlated with more instrumental support provision. Male providers scoring higher on affective empathy (i.e., situational personal distress) provided higher levels of instrumental support. Dispositional perspective taking was related to higher scores on emotional support provision for male providers. The current study furthers our insight into the empathy-support link, by revealing differential effects (a) for men and women, (b) of both cognitive and affective empathy, and (c) of dispositional as well as situational empathy, on different types of support provision. PMID:26910769
Significance of beating observed in earthquake responses of buildings
Çelebi, Mehmet; Ghahari, S. F.; Taciroglu, E.
2016-01-01
The beating phenomenon observed in the recorded responses of a tall building in Japan and another in the U.S. are examined in this paper. Beating is a periodic vibrational behavior caused by distinctive coupling between translational and torsional modes that typically have close frequencies. Beating is prominent in the prolonged resonant responses of lightly damped structures. Resonances caused by site effects also contribute to accentuating the beating effect. Spectral analyses and system identification techniques are used herein to quantify the periods and amplitudes of the beating effects from the strong motion recordings of the two buildings. Quantification of beating effects is a first step towards determining remedial actions to improve resilient building performance to strong earthquake induced shaking.
NASA Astrophysics Data System (ADS)
Luhmann, J. G.; Ulusen, D.; Ledvina, S. A.; Mandt, K.; Magee, B.; Waite, J. H.; Westlake, J.; Cravens, T. E.; Robertson, I.; Edberg, N.; Agren, K.; Wahlund, J.-E.; Ma, Y.-J.; Wei, H.; Russell, C. T.; Dougherty, M. K.
2012-06-01
In the ˜6 years since the Cassini spacecraft went into orbit around Saturn in 2004, roughly a dozen Titan flybys have occurred for which the Ion Neutral Mass Spectrometer (INMS) measured that moon's ionospheric density and composition. For these, and for the majority of the ˜60 close flybys probing to altitudes down to ˜950 km, Langmuir Probe electron densities were also obtained. These were all complemented by Cassini magnetometer observations of the magnetic fields affected by the Titan plasma interaction. Titan's ionosphere was expected to differ from those of other unmagnetized planetary bodies because of significant contributions from particle impact due to its magnetospheric environment. However, previous analyses of these data clearly showed the dominance of the solar photon source, with the possible exception of the nightside. This paper describes the collected ionospheric data obtained in the period between Cassini's Saturn Orbit Insertion in 2004 and 2009, and examines some of their basic characteristics with the goal of searching for magnetospheric influences. These influences might include effects on the altitude profiles of impact ionization by magnetospheric particles at the Titan orbit location, or by locally produced pickup ions freshly created in Titan's upper atmosphere. The effects of forces on the ionosphere associated with both the draped and penetrating external magnetic fields might also be discernable. A number of challenges arise in such investigations given both the observed order of magnitude variations in the magnetospheric particle sources and the unsteadiness of the magnetospheric magnetic field and plasma flows at Titan's (˜20Rs (Saturn Radius)) orbit. Transterminator flow of ionospheric plasma from the dayside may also supply some of the nightside ionosphere, complicating determination of the magnetospheric contribution. Moreover, we are limited by the sparse sampling of the ionosphere during the mission as the Titan interaction
Sitnick, Stephanie L.; Shaw, Daniel S.; Gill, Anne; Dishion, Thomas; Winter, Charlotte; Waller, Rebecca; Gardner, Frances; Wilson, Melvin
2016-01-01
Coercion theory posits a cyclical relationship between harsh and coercive parent–child interactions and problem behavior beginning in early childhood. As coercive interactions have been theorized and found to facilitate the development and growth of early conduct problems, early interventions often target parenting to prevent or reduce early disruptive problem behavior. This study utilizes direct observations of parent–child interactions from the Early Steps Multisite study (N = 731; 369 boys) to examine the effect of the Family Check-Up, a family-centered intervention program, on measures of parent–child positive engagement and coercion from age 2 through 5, as well as on childhood problem behavior at age 5. Results indicate that high levels of parent–child positive engagement were associated with less parent–child coercion the following year, but dyadic coercion was unrelated to future levels of positive engagement. In addition, families assigned to the Family Check-Up showed increased levels of positive engagement at ages 3 and 5, and the association between positive engagement at age 3 and child problem behavior at age 5 was mediated by reductions in parent–child coercion at age 4. These findings provide longitudinal confirmation that increasing positive engagement in parent–child interaction can reduce the likelihood of coercive family dynamics in early childhood and growth in problem behavior. PMID:25133754
Sitnick, Stephanie L; Shaw, Daniel S; Gill, Anne; Dishion, Thomas; Winter, Charlotte; Waller, Rebecca; Gardner, Frances; Wilson, Melvin
2015-01-01
Coercion theory posits a cyclical relationship between harsh and coercive parent-child interactions and problem behavior beginning in early childhood. As coercive interactions have been theorized and found to facilitate the development and growth of early conduct problems, early interventions often target parenting to prevent or reduce early disruptive problem behavior. This study utilizes direct observations of parent-child interactions from the Early Steps Multisite study (N = 731; 369 boys) to examine the effect of the Family Check-Up, a family-centered intervention program, on measures of parent-child positive engagement and coercion from age 2 through 5, as well as on childhood problem behavior at age 5. Results indicate that high levels of parent-child positive engagement were associated with less parent-child coercion the following year, but dyadic coercion was unrelated to future levels of positive engagement. In addition, families assigned to the Family Check-Up showed increased levels of positive engagement at ages 3 and 5, and the association between positive engagement at age 3 and child problem behavior at age 5 was mediated by reductions in parent-child coercion at age 4. These findings provide longitudinal confirmation that increasing positive engagement in parent-child interaction can reduce the likelihood of coercive family dynamics in early childhood and growth in problem behavior.
Interactive effects of nutrient additions and predation on infaunal communities
Posey, M.H.; Alphin, T.D.; Cahoon, L.; Lindquist, D.; Becker, M.E.
1999-01-01
Nutrient additions represent an important anthropogenic stress on coastal ecosystems. At moderate levels, increased nutrients may lead to increased primary production and, possibly, to increased biomass of consumers although complex trophic interactions may modify or mask these effects. We examined the influence of nutrient additions and interactive effects of trophic interactions (predation) on benthic infaunal composition and abundances through small-scale field experiments in 2 estuaries that differed in ambient nutrient conditions. A blocked experimental design was used that allowed an assessment of direct nutrient effects in the presence and absence of predation by epibenthic predators as well as an assessment of the independent effects of predation. Benthic microalgal production increased with experimental nutrient additions and was greater when infaunal abundances were lower, but there were no significant interactions between these factors. Increased abundances of one infaunal taxa, Laeonereis culveri, as well as the grazer feeding guild were observed with nutrient additions and a number of taxa exhibited higher abundances with predator exclusion. In contrast to results from freshwater systems there were no significant interactive effects between nutrient additions and predator exclusion as was predicted. The infaunal responses observed here emphasize the importance of both bottom-up (nutrient addition and primary producer driven) and top-down (predation) controls in structuring benthic communities. These processes may work at different spatial and temporal scales, and affect different taxa, making observation of potential interactive effects difficult.
Gender differences in teacher-student interactions in science classrooms
NASA Astrophysics Data System (ADS)
Jones, M. Gail; Wheatley, Jack
1990-12-01
Thirty physical science and 30 chemistry classes, which contained a total of 1332 students, were observed using the Brophy-Good Teacher-Child Dyadic Interaction System. Classroom interactions were examined for gender differences that may contribute to the underrepresentation of women in physics and engineering courses and subsequent careers. The Brophy-Good coding process allows for examination of patterns of interactions for individuals and groups of pupils. An analysis of variance of the data yielded a significant main effect for teacher praise, call outs, procedural questions, and behavioral warnings based on the sex of the student and a significant teacher-sex main effect for direct questions. Significant two-way interactions were found for the behavioral warning variable for teacher sex and subject by student sex. Female teachers warned male students significantly more than female students. Male teachers warned both genders with similar frequency. Male students also received significantly more behavioral warnings in physical science classes than female students. In chemistry classes, both male and female students received approximately the same number of behavioral warnings.
Saito, Teruo; Tatematsu, Yoshinori; Yamaguchi, Yuusuke; Ikeuchi, Shinji; Ogasawara, Shinya; Yamada, Naoki; Ikeda, Ryosuke; Ogawa, Isamu; Idehara, Toshitaka
2012-10-12
Dynamic mode interaction between fundamental and second-harmonic modes has been observed in high-power sub-terahertz gyrotrons [T. Notake et al., Phys. Rev. Lett. 103, 225002 (2009); T. Saito et al. Phys. Plasmas 19, 063106 (2012)]. Interaction takes place between a parasitic fundamental or first-harmonic (FH) mode and an operating second-harmonic (SH) mode, as well as among SH modes. In particular, nonlinear excitation of the parasitic FH mode in the hard self-excitation regime with assistance of a SH mode in the soft self-excitation regime was clearly observed. Moreover, both cases of stable two-mode oscillation and oscillation of the FH mode only were observed. These observations and theoretical analyses of the dynamic behavior of the mode interaction verify the nonlinear hard self-excitation of the FH mode.
Global Magnetospheric Response to an Interplanetary Shock: THEMIS Observations
NASA Technical Reports Server (NTRS)
Zhang, Hui; Sibeck, David G.; Zong, Q.-G.; McFadden, James P.; Larson, Davin; Glassmeier, K.-H.; Angelopoulos, V.
2011-01-01
We investigate the global response of geospace plasma environment to an interplanetary shock at approx. 0224 UT on May 28, 2008 from multiple THEMIS spacecraft observations in the magnetosheath (THEMIS B and C) and the mid-afternoon (THEMIS A) and dusk magnetosphere (THEMIS D and E). The interaction of the transmitted interplanetary shock with the magnetosphere has global effects. Consequently, it can affect geospace plasma significantly. After interacting with the bow shock, the interplanetary shock transmitted a fast shock and a discontinuity which propagated through the magnetosheath toward the Earth at speeds of 300 km/s and 137 km/s respectively. THEMIS A observations indicate that the plasmaspheric plume changed significantly by the interplanetary shock impact. The plasmaspheric plume density increased rapidly from 10 to 100/ cubic cm in 4 min and the ion distribution changed from isotropic to strongly anisotropic distribution. Electromagnetic ion cyclotron (EMIC) waves observed by THEMIS A are most likely excited by the anisotropic ion distributions caused by the interplanetary shock impact. To our best knowledge, this is the first direct observation of the plasmaspheric plume response to an interplanetary shock's impact. THEMIS A, but not D or E, observed a plasmaspheric plume in the dayside magnetosphere. Multiple spacecraft observations indicate that the dawn-side edge of the plasmaspheric plume was located between THEMIS A and D (or E).
Jothi, Raja; Cherukuri, Praveen F.; Tasneem, Asba; Przytycka, Teresa M.
2006-01-01
Recent advances in functional genomics have helped generate large-scale high-throughput protein interaction data. Such networks, though extremely valuable towards molecular level understanding of cells, do not provide any direct information about the regions (domains) in the proteins that mediate the interaction. Here, we performed co-evolutionary analysis of domains in interacting proteins in order to understand the degree of co-evolution of interacting and non-interacting domains. Using a combination of sequence and structural analysis, we analyzed protein–protein interactions in F1-ATPase, Sec23p/Sec24p, DNA-directed RNA polymerase and nuclear pore complexes, and found that interacting domain pair(s) for a given interaction exhibits higher level of co-evolution than the noninteracting domain pairs. Motivated by this finding, we developed a computational method to test the generality of the observed trend, and to predict large-scale domain–domain interactions. Given a protein–protein interaction, the proposed method predicts the domain pair(s) that is most likely to mediate the protein interaction. We applied this method on the yeast interactome to predict domain–domain interactions, and used known domain–domain interactions found in PDB crystal structures to validate our predictions. Our results show that the prediction accuracy of the proposed method is statistically significant. Comparison of our prediction results with those from two other methods reveals that only a fraction of predictions are shared by all the three methods, indicating that the proposed method can detect known interactions missed by other methods. We believe that the proposed method can be used with other methods to help identify previously unrecognized domain–domain interactions on a genome scale, and could potentially help reduce the search space for identifying interaction sites. PMID:16949097
Gibson, Jenny; Hussain, Jamilla; Holsgrove, Samina; Adams, Catherine; Green, Jonathan
2011-01-01
Direct observation of peer relating is potentially a sensitive and ecologically valid measure of child social functioning, but there has been a lack of standardised methods. The Manchester Inventory for Playground Observation (MIPO) was developed as a practical yet rigorous assessment of this kind for 5-11 year olds. We report on the initial reliability and validity of the MIPO and its ability to distinguish social impairments within different psychopathologies. We observed 144 clinically referred children aged 5;00-11;11 (mean 8.8) years with Externalising (n = 44), Internalising (n = 19), Autism Spectrum Disorders (n = 39) or Specific Language Impairment (n = 42), and 44 class-controls, in naturalistic playground interaction. Observers, blind to clinical diagnosis, completed the MIPO and the teacher checklist from the Social Skills Rating System (SSRS). MIPO items showed high internal consistency (alpha = .924; all 'alpha if item deleted' values>.91), inter-observer reliability (mean κ(w) = .77) and test-retest stability (over 2 weeks; mean κ(w) = .58). MIPO totals showed convergence with SSRS (n = 68, r(s) = .78, p<.01) and excellent discrimination between case and control (sensitivity = 0.75 and specificity = 0.88, AUC = .897). Externalising, Autistic Spectrum and Language Impaired groups showed distinct profiles of MIPO impairment consistent with theory:Internalising disorders less so. 65.3% of clinical cases were classified accurately for primary diagnosis. The MIPO shows reliability and validity as a measure of children's social functioning relevant in developmental research and as a clinical tool to aid differential diagnosis and intervention planning. Copyright © 2011 Elsevier Ltd. All rights reserved.
Chan, Lingtak-Neander
2013-07-01
Drug-nutrient interactions are defined as physical, chemical, physiologic, or pathophysiologic relationships between a drug and a nutrient. The causes of most clinically significant drug-nutrient interactions are usually multifactorial. Failure to identify and properly manage drug-nutrient interactions can lead to very serious consequences and have a negative impact on patient outcomes. Nevertheless, with thorough review and assessment of the patient's history and treatment regimens and a carefully executed management strategy, adverse events associated with drug-nutrient interactions can be prevented. Based on the physiologic sequence of events after a drug or a nutrient has entered the body and the mechanism of interactions, drug-nutrient interactions can be categorized into 4 main types. Each type of interaction can be managed using similar strategies. The existing data that guide the clinical management of most drug-nutrient interactions are mostly anecdotal experience, uncontrolled observations, and opinions, whereas the science in understanding the mechanism of drug-nutrient interactions remains limited. The challenge for researchers and clinicians is to increase both basic and higher level clinical research in this field to bridge the gap between the science and practice. The research should aim to establish a better understanding of the function, regulation, and substrate specificity of the nutrient-related enzymes and transport proteins present in the gastrointestinal tract, as well as assess how the incidence and management of drug-nutrient interactions can be affected by sex, ethnicity, environmental factors, and genetic polymorphisms. This knowledge can help us develop a true personalized medicine approach in the prevention and management of drug-nutrient interactions.
Interactions between deep convective clouds and aerosols as observed by satellites
NASA Astrophysics Data System (ADS)
Yuan, T.; Li, Z. I.; Remer, L.; Martins, V.
2008-12-01
Major uncertainties regarding interactions between deep convective clouds (DCC) exist due partly to observational difficulty and partly to the entanglement among remotely sensed properties of aerosols and clouds and entanglement between meteorology and possible aerosol signals. In this study we adopt a novel, physically sound relationship between cloud crystal effective radius(CER) and brightness temperature (BT) and utilize ample sampling opportunity provided by MODIS instrument. We reveal aerosol impacts on DCCs by analyzing an ensemble data. Through a conceptual model we demonstrate how aerosol may affect DCC properties. We outline a few scenarios where aerosol signals are best separated and pronounced. Based on our results, anthropogenic pollutions and smokes are shown to effectively decrease CER and to elevate glaciation level of DCCs. On the other hand, dust particles from local sources have the opposite effects, namely, increasing cloud ice particle size and enhancing glaciation by acting possibly as giant CCN or IN. Implications of these effects for aerosols are discussed along with feedbacks of these effects to dynamics.
Design of an Experiment to Observe Laser-Plasma Interactions on NIKE
NASA Astrophysics Data System (ADS)
Phillips, L.; Weaver, J.; Manheimer, W.; Zalesak, S.; Schmitt, A.; Fyfe, D.; Afeyan, B.; Charbonneau-Lefort, M.
2007-11-01
Recent proposed designs (Obenschain et al., Phys. Plasmas 13 056320 (2006)) for direct-drive ICF targets for energy applications involve high implosion velocities combined with higher laser irradiances. The use of high irradiances increases the likelihood of deleterious laser plasma instabilities (LPI) that may lead, for example, to the generation of fast electrons. The proposed use of a 248 nm KrF laser to drive these targets is expected to minimize LPI; this is being studied by experiments at NRL's NIKE facility. We used a modification of the FAST code that models laser pulses with arbitrary spatial and temporal profiles to assist in designing these experiments. The goal is to design targets and pulseshapes to create plasma conditions that will produce sufficient growth of LPI to be observable on NIKE. Using, for example, a cryogenic DT target that is heated by a brief pulse and allowed to expand freely before interacting with a second, high-intensity pulse, allows the development of long scalelengths at low electron temperatures and leads to a predicted 20-efold growth in two-plasmon amplitude.
Yanagiuchi, Akihiro; Miyake, Hideaki; Tanaka, Kazushi; Fujisawa, Masato
2014-01-01
Several recent studies have reported the involvement of bladder dysfunction in the delayed recovery of urinary continence following radical prostatectomy (RP). The objective of this study was to investigate the significance of detrusor overactivity (DO) as a predictor of the early continence status following robot-assisted RP (RARP). This study included 84 consecutive patients with prostate cancer undergoing RARP. Urodynamic studies, including filling cystometry, pressure flow study, electromyogram of the external urethral sphincter and urethral pressure profile, were performed in these patients before surgery. Urinary continence was defined as the use of either no or one pad per day as a precaution only. DO was preoperatively observed in 30 patients (35.7%), and 55 (65.5%) and 34 (40.5%) were judged to be incontinent 1 and 3 months after RARP, respectively. At both 1 and 3 months after RARP, the incidences of incontinence in patients with DO were significantly higher than in those without DO. Of several demographic and urodynamic parameters, univariate analyses identified DO and maximal urethral closure pressure (MUCP) as significant predictors of the continence status at both 1 and 3 months after RARP. Furthermore, DO and MUCP appeared to be independently associated with the continence at both 1 and 3 months after RARP on multivariate analysis. These findings suggest that preoperatively observed DO could be a significant predictor of urinary incontinence early after RARP; therefore, it is recommended to perform urodynamic studies for patients who are scheduled to undergo RARP in order to comprehensively evaluate their preoperative vesicourethral functions. PMID:25038181
Using metabarcoding to reveal and quantify plant-pollinator interactions
Pornon, André; Escaravage, Nathalie; Burrus, Monique; Holota, Hélène; Khimoun, Aurélie; Mariette, Jérome; Pellizzari, Charlène; Iribar, Amaia; Etienne, Roselyne; Taberlet, Pierre; Vidal, Marie; Winterton, Peter; Zinger, Lucie; Andalo, Christophe
2016-01-01
Given the ongoing decline of both pollinators and plants, it is crucial to implement effective methods to describe complex pollination networks across time and space in a comprehensive and high-throughput way. Here we tested if metabarcoding may circumvent the limits of conventional methodologies in detecting and quantifying plant-pollinator interactions. Metabarcoding experiments on pollen DNA mixtures described a positive relationship between the amounts of DNA from focal species and the number of trnL and ITS1 sequences yielded. The study of pollen loads of insects captured in plant communities revealed that as compared to the observation of visits, metabarcoding revealed 2.5 times more plant species involved in plant-pollinator interactions. We further observed a tight positive relationship between the pollen-carrying capacities of insect taxa and the number of trnL and ITS1 sequences. The number of visits received per plant species also positively correlated to the number of their ITS1 and trnL sequences in insect pollen loads. By revealing interactions hard to observe otherwise, metabarcoding significantly enlarges the spatiotemporal observation window of pollination interactions. By providing new qualitative and quantitative information, metabarcoding holds great promise for investigating diverse facets of interactions and will provide a new perception of pollination networks as a whole. PMID:27255732
NASA Astrophysics Data System (ADS)
George, Rhea
The influence of anthropogenic aerosols on cloud radiative properties in the persistent southeast Pacific stratocumulus deck is investigated using MODIS satellite observations, in situ data from the VAMOS Ocean-Cloud-Atmosphere-Land Study Regional Experiment (VOCALS-REx), and WRF-Chem, a regional model with interactive chemistry and aerosols. An albedo proxy is derived based on the fractional coverage of low cloud (a macrophysical field) and the cloud albedo, with the latter broken down into contributions from microphysics (cloud droplet concentration, Nd and macrophysics (liquid water path). Albedo variability is dominated by low cloud fraction variability, except within 10-15° of the South American coast, where cloud albedo variability contributes significantly. Covariance between cloud fraction and cloud albedo also contributes significantly to the variance in albedo, which highlights how complex and inseparable the factors controlling albedo are. N d variability contributes only weakly, which emphasizes that attributing albedo variability to the indirect effects of aerosols against the backdrop of natural meteorological variability is extremely challenging. Specific cases of aerosol changes can have strong impacts on albedo. We identify a pathway for periodic anthropogenic aerosol transport to the unpolluted marine stratocumulus >1000 km offshore, which strongly enhances Nd and albedo in zonally-elongated 'hook'-shaped arc. Hook development occurs with Nd increasing to polluted levels over the remote ocean primarily due to entrainment of a large number of small aerosols from the free troposphere that contribute a relatively small amount of aerosol mass to the marine boundary layer. Strong, deep offshore flow needed to transport continental aerosols to the remote ocean is favored by a trough approaching the South American coast and a southeastward shift of the climatological subtropical high pressure system. DMS significantly influences the aerosol number and
Chandra Observation of the WAT Radio Source/ICM Interaction in Abell 623
NASA Astrophysics Data System (ADS)
Anand, Gagandeep; Blanton, Elizabeth L.; Randall, Scott W.; Paterno-Mahler, Rachel; Douglass, Edmund
2017-01-01
Galaxy clusters are important objects for studying the physics of the intracluster medium (ICM), galaxy formation and evolution, and cosmological parameters. Clusters containing wide-angle tail (WAT) radio sources are particularly valuable for studies of the interaction between these sources and the surrounding ICM. These sources are thought to form when the ram pressure from the ICM caused by the relative motion between the host radio galaxy and the cluster bends the radio lobes into a distinct wide-angle morphology. We present our results from the analysis of a Chandra observation of the nearby WAT hosting galaxy cluster Abell 623. A clear decrement in X-ray emission is coincident with the southern radio lobe, consistent with being a cavity carved out by the radio source. We present profiles of surface brightness, temperature, density, and pressure and find evidence for a possible shock. Based on the X-ray pressure in the vicinity of the radio lobes and assumptions about the content of the lobes, we estimate the relative ICM velocity required to bend the lobes into the observed angle. We also present spectral model fits to the overall diffuse cluster emission and see no strong signature for a cool core. The sum of the evidence indicates that Abell 623 may be undergoing a large scale cluster-cluster merger.
Asan, Onur; Montague, Enid
2014-01-01
The purpose of this paper is to describe the use of video-based observation research methods in primary care environment and highlight important methodological considerations and provide practical guidance for primary care and human factors researchers conducting video studies to understand patient-clinician interaction in primary care settings. We reviewed studies in the literature which used video methods in health care research, and we also used our own experience based on the video studies we conducted in primary care settings. This paper highlighted the benefits of using video techniques, such as multi-channel recording and video coding, and compared "unmanned" video recording with the traditional observation method in primary care research. We proposed a list that can be followed step by step to conduct an effective video study in a primary care setting for a given problem. This paper also described obstacles, researchers should anticipate when using video recording methods in future studies. With the new technological improvements, video-based observation research is becoming a promising method in primary care and HFE research. Video recording has been under-utilised as a data collection tool because of confidentiality and privacy issues. However, it has many benefits as opposed to traditional observations, and recent studies using video recording methods have introduced new research areas and approaches.
Dou, Bang; Mei, Jiong; Wang, Zhiyuan; Ni, Ming; Jia, Guangyao; Liu, Shiwei
2018-01-01
The retinacular arteries provide major supply to the femoral head, their injuries may lead to the femoral head necrosis (FHN) in femoral neck fractures. Although the femoral neck fracture was seriously displaced in some patients, FHN did not occur, which suggests that the blood supply is not fully blocked. This study was aimed to find the association between the structure of the retinacula of Weitbrecht and the mechanism of protecting retinacular arteries from being injured. Fourteen formalin-fixed cadaveric specimens (in 28 hips) with no significant vascular disease were observed. The retinacula were cut longitudinally and then cut into three parts: medial, middle, and lateral. These specimens were stained using hematoxylin and eosin and improved Masson Trichrome stain. The microstructure and tightness of the retinacula fixed to the bone and the distribution of vessels were examined under a stereoscope, an optical microscope, and a scanning electron microscope. The microstructure and compactness in each part of retinacula were different, and the tightness of the fibers of the retinacula fixed to the bone in each part were different. A particular structure which resembled a Sandwich panels was observed, and it may be an effective mechanism of protecting retinacular arteries. The Sandwich panels structure existed generally in the retinacula of Weitbrecht, and this sandwich panelture may play very important role in protecting the retinaculum artery from being injured, which show the importance of protecting the retinacular artery in the treatment of femoral neck fractures.
Pelassa, Ilaria; Fiumara, Ferdinando
2015-01-01
Homopolymeric amino acids repeats (AARs), which are widespread in proteomes, have often been viewed simply as spacers between protein domains, or even as “junk” sequences with no obvious function but with a potential to cause harm upon expansion as in genetic diseases associated with polyglutamine or polyalanine expansions, including Huntington disease and cleidocranial dysplasia. A growing body of evidence indicates however that at least some AARs can form organized, functional protein structures, and can regulate protein function. In particular, certain AARs can mediate protein-protein interactions, either through homotypic AAR-AAR contacts or through heterotypic contacts with other protein domains. It is still unclear however, whether AARs may have a generalized, proteome-wide role in shaping protein-protein interaction networks. Therefore, we have undertaken here a bioinformatics screening of the human proteome and interactome in search of quantitative evidence of such a role. We first identified the sets of proteins that contain repeats of any one of the 20 amino acids, as well as control sets of proteins chosen at random in the proteome. We then analyzed the connectivity between the proteins of the AAR-containing protein sets and we compared it with that observed in the corresponding control networks. We find evidence for different degrees of connectivity in the different AAR-containing protein networks. Indeed, networks of proteins containing polyglutamine, polyglutamate, polyproline, and other AARs show significantly increased levels of connectivity, whereas networks containing polyleucine and other hydrophobic repeats show lower degrees of connectivity. Furthermore, we observed that numerous protein-protein, -nucleic acid, and -lipid interaction domains are significantly enriched in specific AAR protein groups. These findings support the notion of a generalized, combinatorial role of AARs, together with conventional protein interaction domains, in
NASA Astrophysics Data System (ADS)
Tews, I.; Carlson, J.; Gandolfi, S.; Reddy, S.
2018-06-01
The dense matter equation of state (EOS) determines neutron star (NS) structure but can be calculated reliably only up to one to two times the nuclear saturation density, using accurate many-body methods that employ nuclear interactions from chiral effective field theory constrained by scattering data. In this work, we use physically motivated ansatzes for the speed of sound c S at high density to extend microscopic calculations of neutron-rich matter to the highest densities encountered in stable NS cores. We show how existing and expected astrophysical constraints on NS masses and radii from X-ray observations can constrain the speed of sound in the NS core. We confirm earlier expectations that c S is likely to violate the conformal limit of {c}S2≤slant {c}2/3, possibly reaching values closer to the speed of light c at a few times the nuclear saturation density, independent of the nuclear Hamiltonian. If QCD obeys the conformal limit, we conclude that the rapid increase of c S required to accommodate a 2 M ⊙ NS suggests a form of strongly interacting matter where a description in terms of nucleons will be unwieldy, even between one and two times the nuclear saturation density. For typical NSs with masses in the range of 1.2–1.4 M ⊙, we find radii between 10 and 14 km, and the smallest possible radius of a 1.4 M ⊙ NS consistent with constraints from nuclear physics and observations is 8.4 km. We also discuss how future observations could constrain the EOS and guide theoretical developments in nuclear physics.
Probing interaction and spatial curvature in the holographic dark energy model
DOE Office of Scientific and Technical Information (OSTI.GOV)
Li, Miao; Li, Xiao-Dong; Wang, Shuang
2009-12-01
In this paper we place observational constraints on the interaction and spatial curvature in the holographic dark energy model. We consider three kinds of phenomenological interactions between holographic dark energy and matter, i.e., the interaction term Q is proportional to the energy densities of dark energy (ρ{sub Λ}), matter (ρ{sub m}), and matter plus dark energy (ρ{sub m}+ρ{sub Λ}). For probing the interaction and spatial curvature in the holographic dark energy model, we use the latest observational data including the type Ia supernovae (SNIa) Constitution data, the shift parameter of the cosmic microwave background (CMB) given by the five-year Wilkinsonmore » Microwave Anisotropy Probe (WMAP5) observations, and the baryon acoustic oscillation (BAO) measurement from the Sloan Digital Sky Survey (SDSS). Our results show that the interaction and spatial curvature in the holographic dark energy model are both rather small. Besides, it is interesting to find that there exists significant degeneracy between the phenomenological interaction and the spatial curvature in the holographic dark energy model.« less
CAVALCANTI, Andrea Nóbrega; MARCHI, Giselle Maria; AMBROSANO, Gláucia Maria Bovi
2010-01-01
Statistical analysis interpretation is a critical field in scientific research. When there is more than one main variable being studied in a research, the effect of the interaction between those variables is fundamental on experiments discussion. However, some doubts can occur when the p-value of the interaction is greater than the significance level. Objective To determine the most adequate interpretation for factorial experiments with p-values of the interaction nearly higher than the significance level. Materials and methods The p-values of the interactions found in two restorative dentistry experiments (0.053 and 0.068) were interpreted in two distinct ways: considering the interaction as not significant and as significant. Results Different findings were observed between the two analyses, and studies results became more coherent when the significant interaction was used. Conclusion The p-value of the interaction between main variables must be analyzed with caution because it can change the outcomes of research studies. Researchers are strongly advised to interpret carefully the results of their statistical analysis in order to discuss the findings of their experiments properly. PMID:20857003
Interactive Social Neuroscience to Study Autism Spectrum Disorder
Rolison, Max J.; Naples, Adam J.; McPartland, James C.
2015-01-01
Individuals with autism spectrum disorder (ASD) demonstrate difficulty with social interactions and relationships, but the neural mechanisms underlying these difficulties remain largely unknown. While social difficulties in ASD are most apparent in the context of interactions with other people, most neuroscience research investigating ASD have provided limited insight into the complex dynamics of these interactions. The development of novel, innovative “interactive social neuroscience” methods to study the brain in contexts with two interacting humans is a necessary advance for ASD research. Studies applying an interactive neuroscience approach to study two brains engaging with one another have revealed significant differences in neural processes during interaction compared to observation in brain regions that are implicated in the neuropathology of ASD. Interactive social neuroscience methods are crucial in clarifying the mechanisms underlying the social and communication deficits that characterize ASD. PMID:25745371
Interactive social neuroscience to study autism spectrum disorder.
Rolison, Max J; Naples, Adam J; McPartland, James C
2015-03-01
Individuals with autism spectrum disorder (ASD) demonstrate difficulty with social interactions and relationships, but the neural mechanisms underlying these difficulties remain largely unknown. While social difficulties in ASD are most apparent in the context of interactions with other people, most neuroscience research investigating ASD have provided limited insight into the complex dynamics of these interactions. The development of novel, innovative "interactive social neuroscience" methods to study the brain in contexts with two interacting humans is a necessary advance for ASD research. Studies applying an interactive neuroscience approach to study two brains engaging with one another have revealed significant differences in neural processes during interaction compared to observation in brain regions that are implicated in the neuropathology of ASD. Interactive social neuroscience methods are crucial in clarifying the mechanisms underlying the social and communication deficits that characterize ASD.
NASA Astrophysics Data System (ADS)
Streltsov, A. V.; Lynch, K. A.; Fernandes, P. A.; Miceli, R.; Hampton, D. L.; Michell, R. G.; Samara, M.
2012-12-01
The MICA (Magnetosphere-Ionosphere Coupling in the Alfvén Resonator) sounding rocket was launched from Poker Flat on February 19, 2012. The rocket was aimed into the system of discrete auroral arcs and during its flight it detected small-scale electromagnetic disturbances with characteristic features of dispersive Alfvén waves. We report results from numerical modeling of these observations. Our simulations are based on a two-fluid MHD model describing multi-scale interactions between magnetic field-aligned currents carried by shear Alfven waves and the ionosphere. The results from our simulations suggest that the small-scale electromagnetic structures measured by MICA indeed can be interpreted as dispersive Alfvén waves generated by the active ionospheric response (ionopspheric feedback instability) inside the large-scale downward magnetic field-aligned current interacting with the ionosphere.
Zhan, Liang-Tong; Xu, Hui; Chen, Yun-Min; Lan, Ji-Wu; Lin, Wei-An; Xu, Xiao-Bing; He, Pin-Jing
2017-10-01
The high food waste content (HFWC) MSW at a landfill has the characteristics of rapid hydrolysis process, large leachate production rate and fast gas generation. The liquid-gas interactions at HFWC-MSW landfills are prominent and complex, and still remain significant challenges. This paper focuses on the liquid-gas interactions of HFWC-MSW observed from a large-scale bioreactor landfill experiment (5m×5m×7.5m). Based on the connected and quantitative analyses on the experimental observations, the following findings were obtained: (1) The high leachate level observed at Chinese landfills was attributed to the combined contribution from the great quantity of self-released leachate, waste compression and gas entrapped underwater. The contribution from gas entrapped underwater was estimated to be 21-28% of the total leachate level. (2) The gas entrapped underwater resulted in a reduction of hydraulic conductivity, decreasing by one order with an increase in gas content from 13% to 21%. (3) The "breakthrough value" in the gas accumulation zone was up to 11kPa greater than the pore liquid pressure. The increase of the breakthrough value was associated with the decrease of void porosity induced by surcharge loading. (4) The self-released leachate from HFWC-MSW was estimated to contribute to over 30% of the leachate production at landfills in Southern China. The drainage of leachate with a high organic loading in the rapid hydrolysis stage would lead to a loss of landfill gas (LFG) potential of 13%. Based on the above findings, an improved method considering the quantity of self-released leachate was proposed for the prediction of leachate production at HFWC-MSW landfills. In addition, a three-dimensional drainage system was proposed to drawdown the high leachate level and hence to improve the slope stability of a landfill, reduce the hydraulic head on a bottom liner and increase the collection efficiency for LFG. Copyright © 2017. Published by Elsevier Ltd.
Eade, Amber M; Youngentob, Lisa M; Youngentob, Steven L
2016-04-01
Using a social transmission of food preference paradigm in rats, we previously demonstrated that ethanol (EtOH) exposure during adolescence, as either an observer (interaction with an intoxicated conspecific) or demonstrator (intragastric infusion with EtOH), altered the reflexive odor-mediated responses to the drug. The 2 modes of exposure were equivalent in the magnitude of their effects. Human adolescents, however, are likely to experience the drug in a social setting as both an EtOH observer and demonstrator. That is, both interacting with an intoxicated peer and experiencing EtOH's postingestive consequences in conjunction with hematogenic olfaction. Therefore, we tested whether combined adolescent exposure as both an observer and demonstrator differed from either form of individual experience. Beginning on postnatal day (P) 29, naïve rats received EtOH or water exposures in a social interaction paradigm as either an observer, a demonstrator, or combined experience (where each animal in the interaction was, itself, an observer and demonstrator). Exposures occurred 4 times, once every 48 hours. On P37, the reflexive behavioral response to EtOH odor was tested, using whole-body plethysmography. The odor-mediated responses of adolescent EtOH observers, demonstrators, and combined exposure animals all significantly differed from controls. Compared to controls, however, the magnitude of the behavioral effect was greatest in the combined exposure animals. Moreover, combined exposure as both an EtOH observer and demonstrator significantly differed from either form of individual EtOH experience. EtOH's component chemosensory qualities are known to be central contributors to its acceptance and increases in the acceptability of EtOH's odor, resulting from a social transmission experience, are predictive of enhanced EtOH avidity in adolescence. Our findings demonstrate that combined exposure as an observer and demonstrator, within a socially relevant framework, may
Interaction of Cracks Between Two Adjacent Indents in Glass
NASA Technical Reports Server (NTRS)
Choi, S. R.; Salem, J. A.
1993-01-01
Experimental observations of the interaction behavior of cracks between two adjacent indents were made using an indentation technique in soda-lime glass. It was specifically demonstrated how one indent crack initiates and propagates in the vicinity of another indent crack. Several types of crack interactions were examined by changing the orientation and distance of one indent relative to the other. It was found that the residual stress field produced by elastic/plastic indentation has a significant influence on controlling the mode of crack interaction. The interaction of an indent crack with a free surface was also investigated for glass and ceramic specimens.
Observations of the interaction between near-inertial waves and mesoscale eddies
NASA Astrophysics Data System (ADS)
Martínez-Marrero, Antonio; Sangrá, Pablo; Caldeira, Rui; Aguiar-González, Borja; Rodríguez-Santana, Ángel
2014-05-01
Trajectories of eight drifters dragged below the surface mixed layer and current meter data from a mooring are used to analyse the interaction between near-inertial waves and mesoscale eddies. Drifters were deployed within eddies generated downstream of Canary and Madeira islands between 1998 and 2007. The mooring was installed in the passage of cyclonic eddies induced by Gran Canaria island during 2006. Rotatory wavelet analysis of Lagrangian velocities shows a clear relationship between the near-inertial waves' intrinsic frequencies and the eddy angular velocities. The results reveal that near-inertial waves reach a minimum frequency of half the planetary vorticity (f/2) in the inner core of young anticyclonic eddies rotating with its maximum absolute angular speed of f/2. The highest amplitudes of the observed inertial motions are also found within anticyclonic eddies evidencing the trapping of inertial waves. Finally, the analysis of the current meter series show frequency fluctuations of the near-inertial currents in the upper 500 meters that are related to the passage of cyclonic eddies. These fluctuations appear to be consistent with the variation of the background vorticity produced by the eddies.
Asan, Onur; Montague, Enid
2015-01-01
Objective The purpose of this paper is to describe the use of video-based observation research methods in primary care environment and highlight important methodological considerations and provide practical guidance for primary care and human factors researchers conducting video studies to understand patient-clinician interaction in primary care settings. Methods We reviewed studies in the literature which used video methods in health care research and, we also used our own experience based on the video studies we conducted in primary care settings. Results This paper highlighted the benefits of using video techniques such as multi-channel recording and video coding and compared “unmanned” video recording with the traditional observation method in primary care research. We proposed a list, which can be followed step by step to conduct an effective video study in a primary care setting for a given problem. This paper also described obstacles researchers should anticipate when using video recording methods in future studies. Conclusion With the new technological improvements, video-based observation research is becoming a promising method in primary care and HFE research. Video recording has been under-utilized as a data collection tool because of confidentiality and privacy issues. However, it has many benefits as opposed to traditional observations, and recent studies using video recording methods have introduced new research areas and approaches. PMID:25479346
Discovering the nature of the star-planet interaction at WASP-12b
NASA Astrophysics Data System (ADS)
Nichols, Jonathan
2013-10-01
In 2010, COS produced a tantalising hint of a significant discovery: the magnetic field of an exoplanet. The ingress of the transiting 'hot-Jupiter' exoplanet WASP-12b apparently occurred earlier in the NUV than in the optical, and two hypotheses have been put forward as explanations. One is that this manifests dense shocked material in a magnetosheath formed in the supersonic stellar wind upstream of the planet's thus-revealed magnetic field, while the other is that this is caused in the absence of a planetary magnetic field by material overflowing the planet's Roche lobe at the L1 point. However, the previous observation, which was not designed to observe this phenomenon, is beset by scattered, sparse data and we do not yet understand the nature of the star-planet interaction. It is thus crucial that we now observe WASP-12b in a program specifically designed to unambiguously detect the early ingress, significantly improve the NUV lightcurve, and answer the question:* What is the nature of the star-planet interaction at WASP-12?No other observatory is capable of making these observations, and this proposal is highly accordant with the purpose of the Cycle 21 UV initiative. Execution in Cycle 21 is also highly desirable since the results will provide input to the LOFAR exoplanet program, which will focus on planets thought to exhibit star-planet interactions. By following a fortuitously obtained pointer, this proposal presents low risk-high impact observations, since the characterisation of star-exoplanet interactions and possibly the first detection of an exoplanetary magnetic field would be of huge scientific significance.
First observation of coherent π production in neutrino nucleus interactions with E<2 GeV
NASA Astrophysics Data System (ADS)
Miniboone Collaboration; Aguilar-Arevalo, A. A.; Anderson, C. E.; Bazarko, A. O.; Brice, S. J.; Brown, B. C.; Bugel, L.; Cao, J.; Coney, L.; Conrad, J. M.; Cox, D. C.; Curioni, A.; Djurcic, Z.; Finley, D. A.; Fleming, B. T.; Ford, R.; Garcia, F. G.; Garvey, G. T.; Green, C.; Green, J. A.; Hart, T. L.; Hawker, E.; Imlay, R.; Johnson, R. A.; Karagiori, G.; Kasper, P.; Katori, T.; Kobilarcik, T.; Kourbanis, I.; Koutsoliotas, S.; Laird, E. M.; Linden, S. K.; Link, J. M.; Liu, Y.; Liu, Y.; Louis, W. C.; Mahn, K. B. M.; Marsh, W.; Martin, P. S.; McGregor, G.; Metcalf, W.; Meyers, P. D.; Mills, F.; Mills, G. B.; Monroe, J.; Moore, C. D.; Nelson, R. H.; Nguyen, V. T.; Nienaber, P.; Nowak, J. A.; Ouedraogo, S.; Patterson, R. B.; Perevalov, D.; Polly, C. C.; Prebys, E.; Raaf, J. L.; Ray, H.; Roe, B. P.; Russell, A. D.; Sandberg, V.; Schirato, R.; Schmitz, D.; Shaevitz, M. H.; Shoemaker, F. C.; Smith, D.; Soderberg, M.; Sorel, M.; Spentzouris, P.; Stancu, I.; Stefanski, R. J.; Sung, M.; Tanaka, H. A.; Tayloe, R.; Tzanov, M.; van de Water, R.; Wascko, M. O.; White, D. H.; Wilking, M. J.; Yang, H. J.; Zeller, G. P.; Zimmerman, E. D.
2008-06-01
The MiniBooNE experiment at Fermilab has amassed the largest sample to date of πs produced in neutral current (NC) neutrino nucleus interactions at low energy. This Letter reports a measurement of the momentum distribution of πs produced in mineral oil (CH2) and the first observation of coherent π production below 2 GeV. In the forward direction, the yield of events observed above the expectation for resonant production is attributed primarily to coherent production off carbon, but may also include a small contribution from diffractive production on hydrogen. Integrated over the MiniBooNE neutrino flux, the sum of the NC coherent and diffractive modes is found to be (19.5±1.1(stat)±2.5(sys))% of all exclusive NC π production at MiniBooNE. These measurements are of immediate utility because they quantify an important background to MiniBooNE's search for ν→ν oscillations.
Research in Observations of Oceanic Air/Sea Interaction
NASA Technical Reports Server (NTRS)
Long, David G.; Arnold, David V.
1995-01-01
The primary purpose of this research has been: (1) to develop an innovative research radar scatterometer system capable of directly measuring both the radar backscatter and the small-scale and large-scale ocean wave field simultaneously and (2) deploy this instrument to collect data to support studies of air/sea interaction. The instrument has been successfully completed and deployed. The system deployment lasted for six months during 1995. Results to date suggest that the data is remarkably useful in air/sea interaction studies. While the data analysis is continuing, two journal and fifteen conference papers have been published. Six papers are currently in review with two additional journal papers scheduled for publication. Three Master's theses on this research have been completed. A Ph.D. student is currently finalizing his dissertation which should be completed by the end of the calendar year. We have received additional 'mainstream' funding from the NASA oceans branch to continue data analysis and instrument operations. We are actively pursuing results from the data expect additional publications to follow. This final report briefly describes the instrument system we developed and results to-date from the deployment. Additional detail is contained in the attached papers selected from the bibliography.
Wang, Yin
2015-01-01
Notwithstanding the significant role that human–robot interactions (HRI) will play in the near future, limited research has explored the neural correlates of feeling eerie in response to social robots. To address this empirical lacuna, the current investigation examined brain activity using functional magnetic resonance imaging while a group of participants (n = 26) viewed a series of human–human interactions (HHI) and HRI. Although brain sites constituting the mentalizing network were found to respond to both types of interactions, systematic neural variation across sites signaled diverging social-cognitive strategies during HHI and HRI processing. Specifically, HHI elicited increased activity in the left temporal–parietal junction indicative of situation-specific mental state attributions, whereas HRI recruited the precuneus and the ventromedial prefrontal cortex (VMPFC) suggestive of script-based social reasoning. Activity in the VMPFC also tracked feelings of eeriness towards HRI in a parametric manner, revealing a potential neural correlate for a phenomenon known as the uncanny valley. By demonstrating how understanding social interactions depends on the kind of agents involved, this study highlights pivotal sub-routes of impression formation and identifies prominent challenges in the use of humanoid robots. PMID:25911418
Magnetosheath jets: MMS observations of internal structures and jet interactions with ambient plasma
NASA Astrophysics Data System (ADS)
Plaschke, F.; Karlsson, T.; Hietala, H.; Archer, M. O.; Voros, Z.; Nakamura, R.; Magnes, W.; Baumjohann, W.; Torbert, R. B.; Russell, C. T.; Giles, B. L.
2017-12-01
The dayside magnetosheath downstream of the quasi-parallel bow shock is commonly permeated by high-speed jets. Under low IMF cone angle conditions, large scale jets alone (with cross-sectional diameters of over 2 Earth radii) have been found to impact the subsolar magnetopause once every 6 minutes - smaller scale jets occurring much more frequently. The consequences of jet impacts on the magnetopause can be significant: they may trigger local reconnection and waves, alter radiation belt electron drift paths, disturb the geomagnetic field, and potentially generate diffuse throat aurora at the dayside ionosphere. Although some basic statistical properties of jets are well-established, their internal structure and interactions with the surrounding magnetosheath plasma are rather unknown. We present Magnetospheric Multiscale (MMS) observations which reveal a rich jet-internal structure of high-amplitude plasma moment and magnetic field variations and associated currents. These variations/structures are generally found to be in thermal and magnetic pressure balance; they mostly (but not always) convect with the plasma flow. Small velocity differences between plasma and structures are revealed via four-spacecraft timing analysis. Inside a jet core region, where the plasma velocity maximizes, structures are found to propagate forward (i.e., with the jet), whereas backward propagation is found outside that core region. Although super-magnetosonic flows are detected by MMS in the spacecraft frame of reference, no fast shock is seen as the jet plasma is sub-magnetosonic with respect to the ambient magnetosheath plasma. Instead, the fast jet plasma pushes ambient magnetosheath plasma ahead of the jet out of the way, possibly generating anomalous sunward flows in the vicinity, and modifies the magnetic field aligning it with the direction of jet propagation.
Chen, Yih-Ru; Hsieh, Fang-I; Lien, Li-Ming; Hu, Chaur-Jong; Jeng, Jiann-Shing; Peng, Giia-Sheun; Tang, Sung-Chun; Chi, Nai-Fang; Sung, Yueh-Feng; Chiou, Hung-Yi
2018-06-02
The effect of RA on recurrent stroke is unknown. Therefore, we examined effects of rheumatoid arthritis (RA) on risk of stroke recurrence and investigated the interaction between RA and traditional cardiovascular risk factors on recurrence risk after ischemic stroke (IS) or transient ischemic attack (TIA). Of 3190 patients with IS or TIA recruited in this cohort study, 638 were comorbid with RA and 2552 without RA. Stroke recurrence, RA, lifestyle, lipid variables and other comorbidities were identified through linkage between a nationwide stroke database in Taiwan and the National Health Insurance claims database. Cox proportional hazard models with competing risk adjustment were used to evaluate the relationship between RA and recurrent stroke. Patients with RA showed a significantly increased risk of recurrent stroke, particular in recurrent IS/TIA. The increased risk of recurrent IS/TIA in RA patients may through the changes of triglycerides (TG)/high-density lipoprotein cholesterol (HDL-C) ratio. A positive additive interaction was observed between RA and current smoking on the risk of recurrent IS/TIA. Significantly increased risks for recurrent IS/TIA were observed among RA patients who smoked > 40 years or those who smoked > 20 cigarettes/day. This study provides the first evidence that RA significantly increased recurrence IS/TIA risk. The changes of TG/HDL-C ratio may play some roles in the recurrence IS/TIA risk in RA patients. In addition, our results suggest that smoking increases the risk of recurrent IS/TIA in RA patients and reinforces the need for aggressive smoking cessation efforts in RA patients.
NASA Astrophysics Data System (ADS)
McComas, D. J.
2009-12-01
The Sun moves through the local interstellar medium, continuously emitting ionized, supersonic solar wind plasma and carving out a cavity in interstellar space, called the heliosphere. The Interstellar Boundary Explorer (IBEX) spacecraft has just completed the first all-sky maps of the interstellar interaction at the edge of the heliosphere, by imaging energetic neutral atoms (ENAs) emanating from this region. IBEX all-sky maps and energy spectra provide detailed information about the interaction. Our observations show globally distributed fluxes ordered by the solar wind structure, which are superposed by another, unexpected feature, which is neither seen by the Voyager spacecraft nor predicted by any current model or theory. This talk summarizes the IBEX observations, shares our unexpected results, and discusses some of the possible ideas for what may be missing in our current understanding of the heliosphere’s global interaction. IBEX Science Team: D.J. McComas1,2, F. Allegrini1,2, P. Bochsler3, M. Bzowski4, E.R. Christian5, G.B. Crew6, R. DeMajistre7, H. Fahr8, H. Fichtner9, P.C. Frisch10, H.O. Funsten11, S. A. Fuselier12, G. Gloeckler13, M. Gruntman14, J. Heerikhuisen15, V. Izmodenov16, P. Janzen17, P. Knappenberger18, S. Krimigis7,19, H. Kucharek20, M. Lee20, G. Livadiotis1, S. Livi1,2, R.J. MacDowall5, D. Mitchell7, E. Möbius20, T. Moore5, N.V. Pogorelov15, D. Reisenfeld17, E. Roelof7, L. Saul3, N.A. Schwadron21, P.W. Valek1,2, R. Vanderspek6, P. Wurz3, G.P. Zank15 (1)Southwest Research Institute, San Antonio, TX, USA (2) University of Texas at San Antonio, San Antonio, TX, USA (3)University of Bern, Physikalisches Institut, CH-3012 Bern, Switzerland (4)Space Research Centre of the Polish Academy of Sciences, Warsaw, Poland (5)NASA Goddard Space Flight Center, Greenbelt, MD, USA (6)Massachusetts Institute of Technology, Cambridge, MA, USA (7)Applied Physics Laboratory, Johns Hopkins University, Laurel, MD, USA (8)University of Bonn, Bonn, Germany (9)Ruhr
Real-time interactive 3D manipulation of particles viewed in two orthogonal observation planes.
Perch-Nielsen, Ivan; Rodrigo, Peter; Glückstad, Jesper
2005-04-18
The generalized phase contrast (GPC) method has been applied to transform a single TEM00 beam into a manifold of counterpropagating-beam traps capable of real-time interactive manipulation of multiple microparticles in three dimensions (3D). This paper reports on the use of low numerical aperture (NA), non-immersion, objective lenses in an implementation of the GPC-based 3D trapping system. Contrary to high-NA based optical tweezers, the GPC trapping system demonstrated here operates with long working distance (>10 mm), and offers a wider manipulation region and a larger field of view for imaging through each of the two opposing objective lenses. As a consequence of the large working distance, simultaneous monitoring of the trapped particles in a second orthogonal observation plane is demonstrated.
Dougherty, Dennis A
2013-04-16
The chemistry community now recognizes the cation-π interaction as a major force for molecular recognition, joining the hydrophobic effect, the hydrogen bond, and the ion pair in determining macromolecular structure and drug-receptor interactions. This Account provides the author's perspective on the intellectual origins and fundamental nature of the cation-π interaction. Early studies on cyclophanes established that water-soluble, cationic molecules would forego aqueous solvation to enter a hydrophobic cavity if that cavity was lined with π systems. Important gas phase studies established the fundamental nature of the cation-π interaction. The strength of the cation-π interaction (Li(+) binds to benzene with 38 kcal/mol of binding energy; NH4(+) with 19 kcal/mol) distinguishes it from the weaker polar-π interactions observed in the benzene dimer or water-benzene complexes. In addition to the substantial intrinsic strength of the cation-π interaction in gas phase studies, the cation-π interaction remains energetically significant in aqueous media and under biological conditions. Many studies have shown that cation-π interactions can enhance binding energies by 2-5 kcal/mol, making them competitive with hydrogen bonds and ion pairs in drug-receptor and protein-protein interactions. As with other noncovalent interactions involving aromatic systems, the cation-π interaction includes a substantial electrostatic component. The six (four) C(δ-)-H(δ+) bond dipoles of a molecule like benzene (ethylene) combine to produce a region of negative electrostatic potential on the face of the π system. Simple electrostatics facilitate a natural attraction of cations to the surface. The trend for (gas phase) binding energies is Li(+) > Na(+) > K(+) > Rb(+): as the ion gets larger the charge is dispersed over a larger sphere and binding interactions weaken, a classical electrostatic effect. On other hand, polarizability does not define these interactions. Cyclohexane is
Huth, Véronique; Sanchez, Yann; Brusque, Corinne
2015-01-01
Phone use while driving has become one of the priority issues in road safety, given that it may lead to decreased situation awareness and deteriorated driving performance. It has been suggested that drivers can regulate their exposure to secondary tasks and seek for compatibility of phone use and driving. Phone use strategies include the choice of driving situations with low demands and interruptions of the interaction when the context changes. Traffic light situations at urban intersections imply both a temptation to use the phone while waiting at the red traffic light and a potential threat due to the incompatibility of phone use and driving when the traffic light turns green. These two situations were targeted in a roadside observation study, with the aim to investigate the existence of a phone use strategy at the red traffic light and to test its effectiveness. N=124 phone users and a corresponding control group of non-users were observed. Strategic phone use behaviour was detected for visual-manual interactions, which are more likely to be initiated at the red traffic light and tend to be stopped before the vehicle moves off, while calls are less likely to be limited to the red traffic light situation. As an indicator of impaired situation awareness, delayed start was associated to phone use and in particular to visual-manual interactions, whether phone use was interrupted before moving off or not. Traffic light situations do not seem to allow effective application of phone use strategies, although drivers attempt to do so for the most demanding phone use mode. The underlying factors of phone use need to be studied so as to reduce the temptation of phone use and facilitate exposure regulation strategies. Copyright © 2014. Published by Elsevier Ltd.
Allen, Joseph; Gregory, Anne; Mikami, Amori; Lun, Janetta; Hamre, Bridget; Pianta, Robert
2017-01-01
Multilevel modeling techniques were used with a sample of 643 students enrolled in 37 secondary school classrooms to predict future student achievement (controlling for baseline achievement) from observed teacher interactions with students in the classroom, coded using the Classroom Assessment Scoring System—Secondary. After accounting for prior year test performance, qualities of teacher interactions with students predicted student performance on end-of-year standardized achievement tests. Classrooms characterized by a positive emotional climate, with sensitivity to adolescent needs and perspectives, use of diverse and engaging instructional learning formats, and a focus on analysis and problem solving were associated with higher levels of student achievement. Effects of higher quality teacher–student interactions were greatest in classrooms with fewer students. Implications for teacher performance assessment and teacher effects on achievement are discussed. PMID:28931966
A Breath of Fresh Air: Students' Perceptions of Interactions with African American Faculty
ERIC Educational Resources Information Center
Neville, Kathleen M.; Parker, Tara L.
2017-01-01
In this phenomenological study we relied on classroom observations and 22 in-depth interviews with students as they interacted with African American faculty. Findings reveal the meaning students made from these classroom interactions and the ways African American faculty, significantly and positively, influenced the student experience. More…
NASA Astrophysics Data System (ADS)
Duan, Yajuan
Light rainfall (< 3 mm/hr) amounts to 30-70% of the annual water budget in the Southern Appalachian Mountains (SAM), a mid-latitude mid-mountain system in the SE CONUS. Topographic complexity favors the diurnal development of regional-scale convergence patterns that provide the moisture source for low-level clouds and fog (LLCF). Low-level moisture and cloud condensation nuclei (CCN) are distributed by ridge-valley circulations favoring LLCF formation that modulate the diurnal cycle of rainfall especially the mid-day peak. The overarching objective of this dissertation is to advance the quantitative understanding of the indirect effect of aerosols on the diurnal cycle of LLCF and warm-season precipitation in mountainous regions generally, and in the SAM in particular, for the purpose of improving the representation of orographic precipitation processes in remote sensing retrievals and physically-based models. The research approach consists of integrating analysis of in situ observations from long-term observation networks and an intensive field campaign, multi-sensor satellite data, and modeling studies. In the first part of this dissertation, long-term satellite observations are analyzed to characterize the spatial and temporal variability of LLCF and to elucidate the physical basis of the space-time error structure in precipitation retrievals. Significantly underestimated precipitation errors are attributed to variations in low-level rainfall microstructure undetected by satellites. Column model simulations including observed LLCF microphysics demonstrate that seeder-feeder interactions (SFI) among upper-level precipitation and LLCF contribute to an three-fold increase in observed rainfall accumulation and can enhance surface rainfall by up to ten-fold. The second part of this dissertation examines the indirect effect of aerosols on cloud formation and warm-season daytime precipitation in the SAM. A new entraining spectral cloud parcel model was developed and
NASA Astrophysics Data System (ADS)
Liu, Yanliang; Li, Kuiping; Ning, Chunlin; Yang, Yang; Wang, Haiyuan; Liu, Jianjun; Skhokiattiwong, Somkiat; Yu, Weidong
2018-02-01
The Andaman Sea (AS) is a poorly observed basin, where even the fundamental physical characteristics have not been fully documented. Here the seasonal variations of the upper ocean structure and the air-sea interactions in the central AS were studied using a moored surface buoy. The seasonal double-peak pattern of the sea surface temperature (SST) was identified with the corresponding mixed layer variations. Compared with the buoys in the Bay of Bengal (BOB), the thermal stratification in the central AS was much stronger in the winter to spring, when a shallower isothermal layer and a thinner barrier layer were sustained. The temperature inversion was strongest from June to July because of substantial surface heat loss and subsurface prewarming. The heat budget analysis of the mixed layer showed that the net surface heat fluxes dominated the seasonal SST cycle. Vertical entrainment was significant from April to July. It had a strong cooling effect from April to May and a striking warming effect from June to July. A sensitivity experiment highlighted the importance of salinity. The AS warmer surface water in the winter was associated with weak heat loss caused by weaker longwave radiation and latent heat losses. However, the AS latent heat loss was larger than the BOB in summer due to its lower relative humidity.
Ohno, Yoshiyuki
2018-01-01
Drug-drug interactions (DDIs) can affect the clearance of various drugs from the body; however, these effects are difficult to sufficiently evaluate in clinical studies. This article outlines our approach to improving methods for evaluating and providing drug information relative to the effects of DDIs. In a previous study, total exposure changes to many substrate drugs of CYP caused by the co-administration of inhibitor or inducer drugs were successfully predicted using in vivo data. There are two parameters for the prediction: the contribution ratio of the enzyme to oral clearance for substrates (CR), and either the inhibition ratio for inhibitors (IR) or the increase in clearance of substrates produced by induction (IC). To apply these predictions in daily pharmacotherapy, the clinical significance of any pharmacokinetic changes must be carefully evaluated. We constructed a pharmacokinetic interaction significance classification system (PISCS) in which the clinical significance of DDIs was considered in a systematic manner, according to pharmacokinetic changes. The PISCS suggests that many current 'alert' classifications are potentially inappropriate, especially for drug combinations in which pharmacokinetics have not yet been evaluated. It is expected that PISCS would contribute to constructing a reliable system to alert pharmacists, physicians and consumers of a broad range of pharmacokinetic DDIs in order to more safely manage daily clinical practices.
Connell, Arin M; Dawson, Glen C; Danzo, Sarah; McKillop, Hannah N
2017-02-01
Parenting is a complex activity driven, in part, by parental emotional and physiological responses. However, work examining the physiological underpinnings of parenting behavior is still in its infancy, and very few studies have examined such processes beyond early childhood. The current study examines associations between Autonomic Nervous System (ANS) indices of parents' physiological reactivity to positive and negative mood states and observed parental affect during a series of discussion tasks with their adolescent child. Respiratory Sinus Arrhythmia (RSA) was measured as an index of parasympathetic nervous system (PNS) activation while viewing film clips designed to induce neutral, sad, and amused mood states. Parental positive affect, anger, and distress were observed during a series of parent-child discussion tasks, which included an ambiguous discussion regarding adolescent growth, a conflict discussion, and a fun-activity planning discussion. Results supported the association between aspects of parental physiological reactivity and observed affect during dyadic interactions. Further, RSA interacted with maternal depression to predict observed positive affect, anger, and distress, although differences across tasks and specific emotions were found regarding the nature of the interaction effects. Overall, results suggest that such neurobiological processes may be particularly important predictors of parental behavior, particularly in at-risk populations. (PsycINFO Database Record (c) 2017 APA, all rights reserved).
ERIC Educational Resources Information Center
Allen, Joseph; Gregory, Anne; Mikami, Amori; Lun, Janetta; Hamre, Bridget; Pianta, Robert
2013-01-01
Multilevel modeling techniques were used with a sample of 643 students enrolled in 37 secondary school classrooms to predict future student achievement (controlling for baseline achievement) from observed teacher interactions with students in the classroom, coded using the Classroom Assessment Scoring System--Secondary. After accounting for prior…
Interplay Between Hydrophobic Effect and Dipole Interactions in Peptide Aggregation
NASA Astrophysics Data System (ADS)
Ganesan, Sai; Matysiak, Silvina
In the past decade, the development of various coarse-grained models for proteins have provided key insights into the driving forces in folding and aggregation.We recently developed a low resolution Water Explicit Polarizable PROtein coarse-grained Model by adding oppositely charged dummy particles inside protein backbone beads.With this model,we were able to achieve significant α/ β secondary structure content,without any added bias.We now extend the model to study peptide aggregation at hydrophobic-hydrophilic interface using elastin-like octapeptides (GV)4 as a model system.A condensation-ordering mechanism of aggregation is observed in water.Our results suggest that backbone interpeptide dipolar interactions,not hydrophobicity,plays a more significant role in fibril-like peptide aggregation.We observe a cooperative effect in hydrogen bonding or dipolar interactions, with increase in aggregate size in water and interface.Based on this cooperative effect, we provide a potential explanation for the observed nucleus size in peptide aggregation pathways.Without dipolar particles,peptide aggregation is not observed at the hydrophilic-hydrophobic interface.Thus,the presence of dipoles,not hydrophobicity plays a key role in aggregation observed at hydrophobic interfaces.
Voyager observations of the interaction of the heliosphere with the interstellar medium
Richardson, John D.
2012-01-01
This paper provides a brief review and update on the Voyager observations of the interaction of the heliosphere with the interstellar medium. Voyager has found many surprises: (1) a new energetic particle component which is accelerated at the termination shock (TS) and leaks into the outer heliosphere forming a foreshock region; (2) a termination shock which is modulated by energetic particles and which transfers most of the solar wind flow energy to the pickup ions (not the thermal ions); (3) the heliosphere is asymmetric; (4) the TS does not accelerate anomalous cosmic rays at the Voyager locations; and (5) the plasma flow in the Voyagers 1 (V1) and 2 (V2) directions are very different. At V1 the flow was small after the TS and has recently slowed to near zero, whereas at V2 the speed has remained constant while the flow direction has turned tailward. V1 may have entered an extended boundary region in front of the heliopause (HP) in 2010 in which the plasma flow speeds are near zero. PMID:25685423
Voyager observations of the interaction of the heliosphere with the interstellar medium.
Richardson, John D
2013-05-01
This paper provides a brief review and update on the Voyager observations of the interaction of the heliosphere with the interstellar medium. Voyager has found many surprises: (1) a new energetic particle component which is accelerated at the termination shock (TS) and leaks into the outer heliosphere forming a foreshock region; (2) a termination shock which is modulated by energetic particles and which transfers most of the solar wind flow energy to the pickup ions (not the thermal ions); (3) the heliosphere is asymmetric; (4) the TS does not accelerate anomalous cosmic rays at the Voyager locations; and (5) the plasma flow in the Voyagers 1 (V1) and 2 (V2) directions are very different. At V1 the flow was small after the TS and has recently slowed to near zero, whereas at V2 the speed has remained constant while the flow direction has turned tailward. V1 may have entered an extended boundary region in front of the heliopause (HP) in 2010 in which the plasma flow speeds are near zero.
Lateral Interactions in Monolayer Thick Mercury Films
NASA Astrophysics Data System (ADS)
Kime, Yolanda Jan
An understanding of lateral adatom-adatom interactions is often an important part of understanding electronic structure and adsorption energetics in monolayer thick films. In this dissertation I use angle-resolved photoemission and thermal desorption spectroscopies to explore the relationship between the adatom-adatom interaction and other characteristics of the adlayer, such as electronic structure, defects, or coexistent structural phases in the adlayer. Since Hg binds weakly to many substrates, the lateral interactions are often a major contribution to the dynamics of the overlayer. Hg adlayer systems are thus ideal for probing lateral interactions. The electronic structures of Hg adlayers on Ag(100), Cu(100), and Cu_3Au(100) are studied with angle-resolved ultraviolet photoemission. The Hg atomic 5d_{5/2} electronic band is observed to split into two levels following adsorption onto some surfaces. The energetic splitting of the Hg 5d_{5/2} level is found to be directly correlated to the adlayer homogeneous strain energy. The existence of the split off level also depends on the order or disorder of the Hg adlayer. The energetics of Hg adsorption on Cu(100) are probed using thermal desorption spectroscopy. Two different ordered adlayer structures are observed for Hg adsorption on Cu(100) at 200 K. Under some adsorption conditions and over a range of exposures, the two phases are seen to coexist on the surface prior to the thermal desorption process. A phase transition from the more dense to the less dense phase is observed to occur during the thermal desorption process. Inherent differences in defect densities are responsible for the observed differences between lateral interactions measured previously with equilibrium (atom beam scattering) and as measured by the non-equilibrium (thermal desorption) technique reported here. Theoretical and experimental evidence for an indirect through-metal interaction between adatoms is also discussed. Although through
Influence of visual observational conditions on tongue motor learning.
Kothari, Mohit; Liu, Xuemei; Baad-Hansen, Lene; Kumar, Abhishek; Bin, Guo; Svensson, Peter
2016-12-01
The aim of this study was to investigate the impact of visual observational conditions on performance during a standardized tongue-protrusion training (TPT) task and to evaluate subject-based reports of helpfulness, disturbance, pain, and fatigue, due to the observational conditions on 0-10 numerical rating scales. Forty-eight healthy participants performed a 1-h standard TPT task. Participants were randomly assigned to one of the following three groups with different observational conditions: group 1, model observation (participants watched a prerecorded video showing standard TPT before optimal TPT being performed); group 2, self-observation (participants watched live video feedback of their own TPT performance); and group 3, control group (participants performed the TPT with no conditioning). There was no overall difference between groups but TPT performance increased over time. A significant group×time interaction indicated that the self-observation group performed significantly better than the model-observation group in the last 20 min of TPT. The subject-based reports of video helpfulness showed that the model-observation group rated the prerecorded video as more helpful for TPT performance compared with the other groups but there was no significant difference between groups regarding the level of disturbance, pain, or fatigue. Self-observation of tongue-training facilitated behavioral aspects of tongue motor learning compared with model observation but not compared with control. © 2016 Eur J Oral Sci.
NASA Astrophysics Data System (ADS)
Chun, Howard; Brinkworth, Carolyn; Ciardi, David; Hoard, Don; Howell, Steve; Stefaniak, Linda; Thomas, Beth
2006-03-01
During the first year of the Spitzer Space Telescope Observing Program for Students and Teachers, our team observed a small sample of short orbital period interacting white dwarf binaries. Our scientific investigation was aimed at detection and characterization of the low mass, cool, brown dwarf-like mass donors in these systems. We used the Infrared Array Camera to obtain photometric observations of the polars EF Eri, GG Leo, V347 Pav, and RX J0154.0-5947 at 3.6, 4.5, 5.8, and 8.0 microns. In all our targets, we detected excess emission in the 3-8 micron region over that expected from a brown dwarf alone. One of the exciting discoveries we made with our IRAC observations is that the star EF Eri was found to be unexpectedly bright in the mid-IR (compared to its 2MASS magnitudes). This fact highlights an opportunity for us to observe EF Eri with the IRS as a follow-up proposal. EF Eri has a flux level of ~700 ?Jy at 8 microns. Thus, we are asking for time to obtain IRS data for only this star, our brightest source. We plan to obtain SL1 (7.4-14.5 microns) and SL2 (5.2-8.7 microns) spectroscopy only. We know the IRAC fluxes so our integration toies are well constrained and the spectral region covered by SL1, SL2 will yield sufficient S/N to differentiate between cool dust (rising BB like spectrum with PAH and other molecular features allowing us to determine dust size, temperature, and disk extent) and a T type dwarf showing characteristic spectral signatures and a falling Rayleigh-Jeans tail.
Gakhar, Gunjan; Bander, Neil H.; Nanus, David M.
2014-01-01
Metastasis is a process in which tumor cells shed from the primary tumor intravasate blood vascular and lymphatic system, thereby, gaining access to extravasate and form a secondary niche. The extravasation of tumor cells from the blood vascular system can be studied using endothelial cells (ECs) and tumor cells obtained from different cell lines. Initial studies were conducted using static conditions but it has been well documented that ECs behave differently under physiological flow conditions. Therefore, different flow chamber assemblies are currently being used to studying cancer cell interactions with ECs. Current flow chamber assemblies offer reproducible results using either different cell lines or fluid at different shear stress conditions. However, to observe and study interactions with rare cells such as circulating tumor cells (CTCs), certain changes are required to be made to the conventional flow chamber assembly. CTCs are a rare cell population among millions of blood cells. Consequently, it is difficult to obtain a pure population of CTCs. Contamination of CTCs with different types of cells normally found in the circulation is inevitable using present enrichment or depletion techniques. In the present report, we describe a unique method to fluorescently label circulating prostate cancer cells and study their interactions with ECs in a self-assembled flow chamber system. This technique can be further applied to observe interactions between prostate CTCs and any protein of interest. PMID:24894373
NASA Astrophysics Data System (ADS)
Burkhart, J. F.; Tallaksen, L. M.; Stordal, F.; Berntsen, T.; Westermann, S.; Kristjansson, J. E.; Etzelmuller, B.; Hagen, J. O.; Schuler, T.; Hamran, S. E.; Lande, T. S.; Bryn, A.
2015-12-01
Climate change is impacting the high latitudes more rapidly and significantly than any other region of the Earth because of feedback processes between the atmosphere and the underlying surface. A warmer climate has already led to thawing of permafrost, reducing snow cover and a longer growing season; changes, which in turn influence the atmospheric circulation and the hydrological cycle. Still, many studies rely on one-way coupling between the atmosphere and the land surface, thereby neglecting important interactions and feedbacks. The observation, understanding and prediction of such processes from local to regional and global scales, represent a major scientific challenge that requires multidisciplinary scientific effort. The successful integration of earth observations (remote and in-situ data) and model development requires a harmonized research effort between earth system scientists, modelers and the developers of technologies and sensors. LATICE, which is recognized as a priority research area by the Faculty of Mathematics and Natural Sciences at the University of Oslo, aims to advance the knowledge base concerning land atmosphere interactions and their role in controlling climate variability and climate change at high northern latitudes. The consortium consists of an interdisciplinary team of experts from the atmospheric and terrestrial (hydrosphere, cryosphere and biosphere) research groups, together with key expertise on earth observations and novel sensor technologies. LATICE addresses critical knowledge gaps in the current climate assessment capacity through: Improving parameterizations of processes in earth system models controlling the interactions and feedbacks between the land (snow, ice, permafrost, soil and vegetation) and the atmosphere at high latitudes, including the boreal, alpine and artic zone. Assessing the influence of climate and land cover changes on water and energy fluxes. Integrating remote earth observations with in-situ data and
Interaction of the Climate System and the Solid Earth: Analysis of Observations and Models
NASA Technical Reports Server (NTRS)
Bryan, Frank
2001-01-01
Under SENH funding we have carried out a number of diverse analyses of interactions of the climate system (atmosphere, ocean, land surface hydrology) with the solid Earth. While the original work plan emphasized analysis of excitation of variations in Earth rotation, with a lesser emphasis on time variable gravity, opportunities that developed during the proposal period in connection with preparations for the GRACE mission led us to a more balanced effort between these two topics. The results of our research are outlined in several topical sections: (1) oceanic excitation of variations in Earth rotation; (2) short period atmosphere-ocean excitation of variations in Earth rotation; (3) analysis of coupled climate system simulation; (4) observing system simulation studies for GRACE mission design; and (5) oceanic response to atmospheric pressure loading.
Schneider, Barry H
2009-07-01
The friendships of socially withdrawn/anxious children and early adolescents have been found to lack critical rewarding qualities. Observational research may help elucidate the obstacles they face in forming and maintaining high-quality friendships with sociable peers. We observed the interactions of 38 socially withdrawn early adolescents with their friends and compared them to a community control group. In negotiating the sharing of an object, the socially withdrawn, anxious group was more passive than controls. The socially withdrawn, anxious participants engaged less actively in a fast-paced game involving miniature cars. While completing a quiet drawing task, the socially anxious, withdrawn participants tended to refrain from comparing their work to that of their friends. In all three of our closed-field situations, the socially withdrawn, anxious participants displayed relatively neutral affect in comparison with the control group. These results suggest that the social withdrawal and social anxiety of children with social phobia are very evident even within the confines of their close friendships. Therefore, therapeutic interventions at the level of the dyad may be indicated.
NASA Astrophysics Data System (ADS)
Kjellander, Roland
2018-05-01
A unified treatment of oscillatory and monotonic exponential decays of interactions in electrolytes is displayed, which highlights the role of dielectric response of the fluid in terms of renormalized (effective) dielectric permittivity and charges. An exact, but physically transparent statistical mechanical formalism is thereby used, which is presented in a systematic, pedagogical manner. Both the oscillatory and monotonic behaviors are given by an equation for the decay length of screened electrostatic interactions that is very similar to the classical expression for the Debye length. The renormalized dielectric permittivities, which have similar roles for electrolytes as the dielectric constant has for pure polar fluids, consist in general of several entities with different physical meanings. They are connected to dielectric response of the fluid on the same length scale as the decay length of the screened interactions. Only in cases where the decay length is very long, these permittivities correspond approximately to a dielectric response in the long-wavelength limit, like the dielectric constant for polar fluids. Experimentally observed long-range exponentially decaying surface forces are analyzed as well as the oscillatory forces observed for short to intermediate surface separations. Both occur in some ionic liquids and in concentrated as well as very dilute electrolyte solutions. The coexisting modes of decay are in general determined by the bulk properties of the fluid and not by the solvation of the surfaces; in the present cases, they are given by the behavior of the screened Coulomb interaction of the bulk fluid. The surface-fluid interactions influence the amplitudes and signs or phases of the different modes of the decay, but not their decay lengths and wavelengths. The similarities between some ionic liquids and very dilute electrolyte solutions as regards both the long-range monotonic and the oscillatory decays are analyzed.
Hemiclonal analysis of interacting phenotypes in male and female Drosophila melanogaster
2014-01-01
Background Identifying the sources of variation in mating interactions between males and females is important because this variation influences the strength and/or the direction of sexual selection that populations experience. While the origins and effects of variation in male attractiveness and ornamentation have received much scrutiny, the causes and consequences of intraspecific variation in females have been relatively overlooked. We used cytogenetic cloning techniques developed for Drosophila melanogaster to create “hemiclonal” males and females with whom we directly observed sexual interaction between individuals of different known genetic backgrounds and measured subsequent reproductive outcomes. Using this approach, we were able to quantify the genetic contribution of each mate to the observed phenotypic variation in biologically important traits including mating speed, copulation duration, and subsequent offspring production, as well as measure the magnitude and direction of intersexual genetic correlation between female choosiness and male attractiveness. Results We found significant additive genetic variation contributing to mating speed that can be attributed to male genetic identity, female genetic identity, but not their interaction. Furthermore we found that phenotypic variation in copulation duration had a significant male-associated genetic component. Female genetic identity and the interaction between male and female genetic identity accounted for a substantial amount of the observed phenotypic variation in egg size. Although previous research predicts a trade-off between egg size and fecundity, this was not evident in our results. We found a strong negative genetic correlation between female choosiness and male attractiveness, a result that suggests a potentially important role for sexually antagonistic alleles in sexual selection processes in our population. Conclusion These results further our understanding of sexual selection because they
The Greening of Pesticide–Environment Interactions: Some Personal Observations
2012-01-01
Background: Pesticide–environment interactions are bidirectional. The environment alters pesticides by metabolism and photodegradation, and pesticides in turn change the environment through nontarget or secondary effects. Objectives: Approximately 900 currently used commercial pesticides of widely diverse structures act by nearly a hundred mechanisms to control insects, weeds, and fungi, usually with minimal disruption of nature’s equilibrium. Here I consider some aspects of the discovery, development, and use of ecofriendly or green pesticides (i.e., pesticides that are safe, effective, and biodegradable with minimal adverse secondary effects on the environment). Emphasis is given to research in my laboratory. Discussion: The need for understanding and improving pesticide–environment interactions began with production of the first major insecticide approximately 150 years ago: The arsenical poison Paris Green was green in color but definitely not ecofriendly. Development and use of other pesticides has led to a variety of problems. Topics considered here include the need for high purity [e.g., hexachlorocyclohexane and polychloroborane isomers and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T)], environmental degradation and the bioactivity of resulting photoproducts and metabolites, pesticide photochemistry (including the use of structural optimization, photostabilizers, and photosensitizers to achieve suitable persistence), the presence of multiple active ingredients in botanical insecticides, the need to consider compounds with common mechanisms of action, issues related to primary and secondary targets, and chemically induced or genetically modified changes in plant biochemistry. Many insecticides are bird, fish, and honeybee toxicants, whereas herbicides and fungicides pose fewer environmental problems. Conclusion: Six factors have contributed to the greening of pesticide–environment interactions: advances in pesticide chemistry and toxicology, banning
The greening of pesticide-environment interactions: some personal observations.
Casida, John E
2012-04-01
Pesticide-environment interactions are bidirectional. The environment alters pesticides by metabolism and photodegradation, and pesticides in turn change the environment through nontarget or secondary effects. Approximately 900 currently used commercial pesticides of widely diverse structures act by nearly a hundred mechanisms to control insects, weeds, and fungi, usually with minimal disruption of nature's equilibrium. Here I consider some aspects of the discovery, development, and use of ecofriendly or green pesticides (i.e., pesticides that are safe, effective, and biodegradable with minimal adverse secondary effects on the environment). Emphasis is given to research in my laboratory. The need for understanding and improving pesticide-environment interactions began with production of the first major insecticide approximately 150 years ago: The arsenical poison Paris Green was green in color but definitely not ecofriendly. Development and use of other pesticides has led to a variety of problems. Topics considered here include the need for high purity [e.g., hexachlorocyclohexane and polychloroborane isomers and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T)], environmental degradation and the bioactivity of resulting photoproducts and metabolites, pesticide photochemistry (including the use of structural optimization, photostabilizers, and photosensitizers to achieve suitable persistence), the presence of multiple active ingredients in botanical insecticides, the need to consider compounds with common mechanisms of action, issues related to primary and secondary targets, and chemically induced or genetically modified changes in plant biochemistry. Many insecticides are bird, fish, and honeybee toxicants, whereas herbicides and fungicides pose fewer environmental problems. Six factors have contributed to the greening of pesticide-environment interactions: advances in pesticide chemistry and toxicology, banning of many chlorinated hydrocarbons, the development of new
A climatologically significant aerosol longwave indirect effect in the Arctic.
Lubin, Dan; Vogelmann, Andrew M
2006-01-26
The warming of Arctic climate and decreases in sea ice thickness and extent observed over recent decades are believed to result from increased direct greenhouse gas forcing, changes in atmospheric dynamics having anthropogenic origin, and important positive reinforcements including ice-albedo and cloud-radiation feedbacks. The importance of cloud-radiation interactions is being investigated through advanced instrumentation deployed in the high Arctic since 1997 (refs 7, 8). These studies have established that clouds, via the dominance of longwave radiation, exert a net warming on the Arctic climate system throughout most of the year, except briefly during the summer. The Arctic region also experiences significant periodic influxes of anthropogenic aerosols, which originate from the industrial regions in lower latitudes. Here we use multisensor radiometric data to show that enhanced aerosol concentrations alter the microphysical properties of Arctic clouds, in a process known as the 'first indirect' effect. Under frequently occurring cloud types we find that this leads to an increase of an average 3.4 watts per square metre in the surface longwave fluxes. This is comparable to a warming effect from established greenhouse gases and implies that the observed longwave enhancement is climatologically significant.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Song, Xia; Hoffman, Forrest M.; Iversen, Colleen M.
Earth system models (ESMs) have been widely used for projecting global vegetation carbon dynamics, yet how well ESMs performed for simulating vegetation carbon density remains untested. Here we have compiled observational data of vegetation carbon density from literature and existing data sets to evaluate nine ESMs at site, biome, latitude, and global scales. Three variables—root (including fine and coarse roots), total vegetation carbon density, and the root:total vegetation carbon ratios (R/T ratios), were chosen for ESM evaluation. ESM models performed well in simulating the spatial distribution of carbon densities in root (r = 0.71) and total vegetation (r = 0.62).more » However, ESM models had significant biases in simulating absolute carbon densities in root and total vegetation biomass across the majority of land ecosystems, especially in tropical and arctic ecosystems. Particularly, ESMs significantly overestimated carbon density in root (183%) and total vegetation biomass (167%) in climate zones of 10°S–10°N. Substantial discrepancies between modeled and observed R/T ratios were found: the R/T ratios from ESMs were relatively constant, approximately 0.2 across all ecosystems, along latitudinal gradients, and in tropic, temperate, and arctic climatic zones, which was significantly different from the observed large variations in the R/T ratios (0.1–0.8). There were substantial inconsistencies between ESM-derived carbon density in root and total vegetation biomass and the R/T ratio at multiple scales, indicating urgent needs for model improvements on carbon allocation algorithms and more intensive field campaigns targeting carbon density in all key vegetation components.« less
Song, Xia; Hoffman, Forrest M.; Iversen, Colleen M.; ...
2017-09-09
Earth system models (ESMs) have been widely used for projecting global vegetation carbon dynamics, yet how well ESMs performed for simulating vegetation carbon density remains untested. Here we have compiled observational data of vegetation carbon density from literature and existing data sets to evaluate nine ESMs at site, biome, latitude, and global scales. Three variables—root (including fine and coarse roots), total vegetation carbon density, and the root:total vegetation carbon ratios (R/T ratios), were chosen for ESM evaluation. ESM models performed well in simulating the spatial distribution of carbon densities in root (r = 0.71) and total vegetation (r = 0.62).more » However, ESM models had significant biases in simulating absolute carbon densities in root and total vegetation biomass across the majority of land ecosystems, especially in tropical and arctic ecosystems. Particularly, ESMs significantly overestimated carbon density in root (183%) and total vegetation biomass (167%) in climate zones of 10°S–10°N. Substantial discrepancies between modeled and observed R/T ratios were found: the R/T ratios from ESMs were relatively constant, approximately 0.2 across all ecosystems, along latitudinal gradients, and in tropic, temperate, and arctic climatic zones, which was significantly different from the observed large variations in the R/T ratios (0.1–0.8). There were substantial inconsistencies between ESM-derived carbon density in root and total vegetation biomass and the R/T ratio at multiple scales, indicating urgent needs for model improvements on carbon allocation algorithms and more intensive field campaigns targeting carbon density in all key vegetation components.« less
DOUGHERTY, DENNIS A.
2014-01-01
CONSPECTUS The chemistry community now recognizes the cation-π interaction as a major force for molecular recognition, joining the hydrophobic effect, the hydrogen bond, and the ion pair in determining macromolecular structure and drug-receptor interactions. This Account provides the author’s perspective on the intellectual origins and fundamental nature of the cation-π interaction. Early studies on cyclophanes established that water-soluble, cationic molecules would forgo aqueous solvation to enter a hydrophobic cavity if that cavity was lined with π systems. Important gas phase studies established the fundamental nature of the cation-π interaction. The strength of the cation-π interaction – Li+ binds to benzene with 38 kcal/mol of binding energy; NH4+ with 19 kcal/mol– distinguishes it from the weaker polar-π interactions observed in the benzene dimer or water-benzene complexes. In addition to the substantial intrinsic strength of the cation-π interaction in gas phase studies, the cation-π interaction remains energetically significant in aqueous media and under biological conditions. Many studies have shown that cation-π interactions can enhance binding energies by 2 – 5 kcal/mol, making them competitive with hydrogen bonds and ion pairs in drug-receptor and protein-protein interactions. As with other noncovalent interactions involving aromatic systems, the cation-π interaction includes a substantial electrostatic component. The six (four) Cδ−–Hδ+ bond dipoles of a molecule like benzene (ethylene) combine to produce a region of negative electrostatic potential on the face of the π system. Simple electrostatics facilitate a natural attraction of cations to the surface. The trend for (gas phase) binding energies is Li+>Na+>K+>Rb+: as the ion gets larger the charge is dispersed over a larger sphere and binding interactions weaken, a classical electrostatic effect. On other hand, polarizability does not define these interactions. Cyclohexane
SDO/AIA AND HINODE/EIS OBSERVATIONS OF INTERACTION BETWEEN AN EUV WAVE AND ACTIVE REGION LOOPS
DOE Office of Scientific and Technical Information (OSTI.GOV)
Yang, Liheng; Zhang, Jun; Li, Ting
2013-09-20
We present detailed analysis of an extreme-ultraviolet (EUV) wave and its interaction with active region (AR) loops observed by the Solar Dynamics Observatory/Atmospheric Imaging Assembly and the Hinode EUV Imaging Spectrometer (EIS). This wave was initiated from AR 11261 on 2011 August 4 and propagated at velocities of 430-910 km s{sup –1}. It was observed to traverse another AR and cross over a filament channel on its path. The EUV wave perturbed neighboring AR loops and excited a disturbance that propagated toward the footpoints of these loops. EIS observations of AR loops revealed that at the time of the wavemore » transit, the original redshift increased by about 3 km s{sup –1}, while the original blueshift decreased slightly. After the wave transit, these changes were reversed. When the EUV wave arrived at the boundary of a polar coronal hole, two reflected waves were successively produced and part of them propagated above the solar limb. The first reflected wave above the solar limb encountered a large-scale loop system on its path, and a secondary wave rapidly emerged 144 Mm ahead of it at a higher speed. These findings can be explained in the framework of a fast-mode magnetosonic wave interpretation for EUV waves, in which observed EUV waves are generated by expanding coronal mass ejections.« less
Climate change and ocean acidification-interactions with aquatic toxicology.
Nikinmaa, Mikko
2013-01-15
The possibilities for interactions between toxicants and ocean acidification are reviewed from two angles. First, it is considered how toxicant responses may affect ocean acidification by influencing the carbon dioxide balance. Second, it is introduced, how the possible changes in environmental conditions (temperature, pH and oxygenation), expected to be associated with climate change and ocean acidification, may interact with the toxicant responses of organisms, especially fish. One significant weakness in available data is that toxicological research has seldom been connected with ecological and physiological/biochemical research evaluating the responses of organisms to temperature, pH or oxygenation changes occurring in the natural environment. As a result, although there are significant potential interactions between toxicants and natural environmental responses pertaining to climate change and ocean acidification, it is very poorly known if such interactions actually occur, and can be behind the observed disturbances in the function and distribution of organisms in our seas. Copyright © 2012 Elsevier B.V. All rights reserved.
ERIC Educational Resources Information Center
Torrens, Paul M.; Griffin, William A.
2013-01-01
The authors describe an observational and analytic methodology for recording and interpreting dynamic microprocesses that occur during social interaction, making use of space--time data collection techniques, spatial-statistical analysis, and visualization. The scheme has three investigative foci: Structure, Activity Composition, and Clustering.…
First observation of coherent π0 production in neutrino-nucleus interactions with Eν < 2 GeV
NASA Astrophysics Data System (ADS)
Aguilar-Arevalo, A. A.; Anderson, C. E.; Bazarko, A. O.; Brice, S. J.; Brown, B. C.; Bugel, L.; Cao, J.; Coney, L.; Conrad, J. M.; Cox, D. C.; Curioni, A.; Djurcic, Z.; Finley, D. A.; Fleming, B. T.; Ford, R.; Garcia, F. G.; Garvey, G. T.; Green, C.; Green, J. A.; Hart, T. L.; Hawker, E.; Imlay, R.; Johnson, R. A.; Karagiori, G.; Kasper, P.; Katori, T.; Kobilarcik, T.; Kourbanis, I.; Koutsoliotas, S.; Laird, E. M.; Linden, S. K.; Link, J. M.; Liu, Y.; Liu, Y.; Louis, W. C.; Mahn, K. B. M.; Marsh, W.; Martin, P. S.; McGregor, G.; Metcalf, W.; Meyers, P. D.; Mills, F.; Mills, G. B.; Monroe, J.; Moore, C. D.; Nelson, R. H.; Nguyen, V. T.; Nienaber, P.; Nowak, J. A.; Ouedraogo, S.; Patterson, R. B.; Perevalov, D.; Polly, C. C.; Prebys, E.; Raaf, J. L.; Ray, H.; Roe, B. P.; Russell, A. D.; Sandberg, V.; Schirato, R.; Schmitz, D.; Shaevitz, M. H.; Shoemaker, F. C.; Smith, D.; Soderberg, M.; Sorel, M.; Spentzouris, P.; Stancu, I.; Stefanski, R. J.; Sung, M.; Tanaka, H. A.; Tayloe, R.; Tzanov, M.; Van de Water, R.; Wascko, M. O.; White, D. H.; Wilking, M. J.; Yang, H. J.; Zeller, G. P.; Zimmerman, E. D.; MiniBooNE Collaboration
2008-06-01
The MiniBooNE experiment at Fermilab has amassed the largest sample to date of π0s produced in neutral current (NC) neutrino-nucleus interactions at low energy. This Letter reports a measurement of the momentum distribution of π0s produced in mineral oil (CH2) and the first observation of coherent π0 production below 2 GeV. In the forward direction, the yield of events observed above the expectation for resonant production is attributed primarily to coherent production off carbon, but may also include a small contribution from diffractive production on hydrogen. Integrated over the MiniBooNE neutrino flux, the sum of the NC coherent and diffractive modes is found to be (19.5 ± 1.1 (stat) ± 2.5 (sys)) % of all exclusive NC π0 production at MiniBooNE. These measurements are of immediate utility because they quantify an important background to MiniBooNE's search for νμ →νe oscillations.
NASA Astrophysics Data System (ADS)
Adhikari, L.; Zank, G. P.; Hunana, P.; Hu, Q.
2016-12-01
Shocks are thought to be responsible for the amplification of turbulence as well as for generating turbulence throughout the heliosphere. We study the interaction of turbulence with parallel and perpendicular shock waves using the six-coupled-equation turbulence transport model of Zank et al. We model a 1D stationary shock wave using a hyperbolic tangent function and the Rankine-Hugoniot conditions for both a reduced model with four coupled equations and the full model. Eight quasi-parallel and five quasi-perpendicular events in the WIND spacecraft data sets are identified, and we compute the fluctuating magnetic and kinetic energy, the energy in forward and backward propagating modes, the total turbulent energy, the normalized residual energy, and the normalized cross helicity upstream and downstream of the observed shocks. We compare the observed fitted values upstream and downstream of the shock with numerical solutions to our model equations. The comparison shows that our theoretical results are in reasonable agreement with observations for both quasi-parallel and perpendicular shocks. We find that (1) the total turbulent energy, the energy in forward and backward propagating modes, and the normalized residual energy increase across the shock, (2) the normalized cross helicity increases or decreases across the shock, and (3) the correlation length increases upstream and downstream of the shock, and slightly flattens or decreases across the shock.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Adhikari, L.; Zank, G. P.; Hunana, P.
Shocks are thought to be responsible for the amplification of turbulence as well as for generating turbulence throughout the heliosphere. We study the interaction of turbulence with parallel and perpendicular shock waves using the six-coupled-equation turbulence transport model of Zank et al. We model a 1D stationary shock wave using a hyperbolic tangent function and the Rankine–Hugoniot conditions for both a reduced model with four coupled equations and the full model. Eight quasi-parallel and five quasi-perpendicular events in the WIND spacecraft data sets are identified, and we compute the fluctuating magnetic and kinetic energy, the energy in forward and backwardmore » propagating modes, the total turbulent energy, the normalized residual energy, and the normalized cross helicity upstream and downstream of the observed shocks. We compare the observed fitted values upstream and downstream of the shock with numerical solutions to our model equations. The comparison shows that our theoretical results are in reasonable agreement with observations for both quasi-parallel and perpendicular shocks. We find that (1) the total turbulent energy, the energy in forward and backward propagating modes, and the normalized residual energy increase across the shock, (2) the normalized cross helicity increases or decreases across the shock, and (3) the correlation length increases upstream and downstream of the shock, and slightly flattens or decreases across the shock.« less
NASA Astrophysics Data System (ADS)
Wang, Binbin; Ma, Yaoming; Ma, Weiqiang; Su, Bob
2017-04-01
Lakes are an important part of the landscape on the Tibetan Plateau. The area that contains most of the plateau lakes has been expanding in recent years, but the impact of lakes on lake-atmosphere energy and water interactions is poorly understood because of a lack of observational data and adequate modeling systems. Furthermore, Precise measurements of evaporation and understanding of the physical controls on turbulent heat flux over lakes at different time scales have fundamental significance for catchment-scale water balance analysis and local-scale climate modeling. To test the performance of lake-air turbulent exchange models over high-altitude lakes and to understanding the driving forces for turbulent heat flux and obtain the actual evaporation over the small high-altitude lakes, an eddy covariance observational system was built above the water surface of the small Nam Co Lake (with an altitude of 4715 m and an area of approximately 1 km2) in April 2012. Firstly, we proposed the proper Charnock coefficient (0.031) and the roughness Reynolds number (0.54) for simulation using turbulent data in 2012, and validated the results using data in 2013 independently; secondly, wind speed shows significance at half-hourly time scales, whereas water vapor and temperature gradients have higher correlations over daily and monthly time scales in lake-air turbulent heat exchange; thirdly, the total evaporation in this small lake (812 mm) is approximately 200 mm larger than that from adjacent Nam Co (approximately 627 mm) during their ice-free seasons. Moreover, the energy stored during April to June is mainly released during September to November, suggesting an energy balance closure value of 0.97 over the entire ice-free season; lastly, 10 evaporation estimation methods are evaluated with the prepared datasets.
n→π* Non-Covalent Interaction is Weak but Strong in Action
NASA Astrophysics Data System (ADS)
Singh, Santosh Kumar; Das, Aloke
2017-06-01
n→π* interaction is a newly discovered non-covalent interaction which involves delocalization of lone pair (n) electrons of an electronegative atom into π* orbital of a carbonyl group or an aromatic ring. It is widely observed in materials, biomolecules (protein, DNA, RNA), amino acids, neurotransmitter and drugs. However, due to its weak strength and counterintuitive nature its existence is debatable. Such weak interactions are often masked by solvent effects in condense phase or physiological conditions thereby, making it difficult to prove the presence of such weak interactions. Therefore, we have used isolated gas phase spectroscopy in combination with quantum chemical calculations to study n→π* interaction in several molecules where, our molecular systems are free from solvent effects or any external forces. Herein I will be discussing two of the molecular systems (phenyl formate and salicin) where, we have observed the significance of n→π* interaction in determining the conformational specificity of the molecules. We have proved the existence of n→π* interaction for the first time through IR spectroscopy by probing the carbonyl stretching frequency of phenyl formate. Our study is further pursued on a drug named salicin where, we have observed that its conformational preferences is ruled by n→π* interaction even though a strong hydrogen bonding interaction is present in the molecule. Our results show that n→π* interaction, in spite of its weak strength, should not be overlooked as it existence can play an important role in governing the structures of molecules like other strong non-covalent interactions do.
Amaro, Christina M.; Devine, Katie A.; Psihogios, Alexandra M.; Murphy, Lexa K.; Holmbeck, Grayson N.
2015-01-01
Objective To examine observed autonomy-promoting and -inhibiting parenting behaviors during preadolescence as predictors of adjustment outcomes in emerging adults with and without spina bifida (SB). Methods Demographic and videotaped interaction data were collected from families with 8/9-year-old children with SB (n = 68) and a matched group of typically developing youth (n = 68). Observed interaction data were coded with macro- and micro-coding schemes. Measures of emerging adulthood adjustment were collected 10 years later (ages 18/19 years; n = 50 and n = 60 for SB and comparison groups, respectively). Results Autonomy-promoting (behavioral control, autonomy-relatedness) and -inhibiting (psychological control) observed preadolescent parenting behaviors prospectively predicted emerging adulthood adjustment, particularly within educational, social, and emotional domains. Interestingly, high parent undermining of relatedness predicted better educational and social adjustment in the SB sample. Conclusions Parenting behaviors related to autonomy have long-term consequences for adjustment in emerging adults with and without SB. PMID:24864277
Wakschlag, Lauren S; Briggs-Gowan, Margaret J; Hill, Carri; Danis, Barbara; Leventhal, Bennett L; Keenan, Kate; Egger, Helen L; Cicchetti, Domenic; Burns, James; Carter, Alice S
2008-06-01
To examine the validity of the Disruptive Behavior Diagnostic Observation Schedule (DB-DOS), a new observational method for assessing preschool disruptive behavior. A total of 327 behaviorally heterogeneous preschoolers from low-income environments comprised the validation sample. Parent and teacher reports were used to identify children with clinically significant disruptive behavior. The DB-DOS assessed observed disruptive behavior in two domains, problems in Behavioral Regulation and Anger Modulation, across three interactional contexts: Examiner Engaged, Examiner Busy, and Parent. Convergent and divergent validity of the DB-DOS were tested in relation to parent and teacher reports and independently observed behavior. Clinical validity was tested in terms of criterion and incremental validity of the DB-DOS for discriminating disruptive behavior status and impairment, concurrently and longitudinally. DB-DOS scores were significantly associated with reported and independently observed behavior in a theoretically meaningful fashion. Scores from both DB-DOS domains and each of the three DB-DOS contexts contributed uniquely to discrimination of disruptive behavior status, concurrently and predictively. Observed behavior on the DB-DOS also contributed incrementally to prediction of impairment over time, beyond variance explained by meeting DSM-IV disruptive behavior disorder symptom criteria based on parent/teacher report. The multidomain, multicontext approach of the DB-DOS is a valid method for direct assessment of preschool disruptive behavior. This approach shows promise for enhancing accurate identification of clinically significant disruptive behavior in young children and for characterizing subtypes in a manner that can directly inform etiological and intervention research.
Interaction between Vaccinium bracteatum Thunb. leaf pigment and rice proteins.
Wang, Li; Xu, Yuan; Zhou, Sumei; Qian, Haifeng; Zhang, Hui; Qi, Xiguang; Fan, Meihua
2016-03-01
In this study, we investigated the interaction of Vaccinium bracteatum Thunb. leaf (VBTL) pigment and rice proteins. In the presence of rice protein, VBTL pigment antioxidant activity and free polyphenol content decreased by 67.19% and 68.11%, respectively, and L(∗) of the protein-pigment complex decreased significantly over time. L(∗) values of albumin, globulin and glutelin during 60-min pigment exposure decreased by 55.00, 57.14, and 54.30%, respectively, indicating that these proteins had bound to the pigment. A significant difference in protein surface hydrophobicity was observed between rice proteins and pigment-protein complexes, indicating that hydrophobic interaction is a major binding mechanism between VBTL pigment and rice proteins. A significant difference in secondary structures between proteins and protein-pigment complexes was also uncovered, indicating that hydrogen bonding may be another mode of interaction between VBTL pigment and rice proteins. Our results indicate that VBTL pigment can stain rice proteins with hydrophobic and hydrogen interactions. Copyright © 2015 Elsevier Ltd. All rights reserved.
Simple Interpretation of Proton-Neutron Interactions in Rare Earth Nuclei
DOE Office of Scientific and Technical Information (OSTI.GOV)
Oktem, Y.; Cakirli, R. B.; Wright Nuclear Structure Laboratory, Yale University, New Haven, CT 06520
2007-04-23
Empirical values of the average interactions of the last two protons and last two neutrons, {delta}Vpn, which can be obtained from double differences of binding energies, provide significant information about nuclear structure. Studies of {delta}Vpn showed striking behavior across major shell gaps and the relation of proton-neutron (p-n) interaction strengths to the increasing collectivity and onset of deformation in nuclei. Here we focus on the strong regularity at the {delta}Vpn values in A{approx}150-180 mass region. Experimentally, for each nucleus, the valence p-n interaction strengths increase systematically against the neutron number and it decreases for the observed last neutron number. Thesemore » experimental results give almost nearly perfect parallel trajectories. A microscopic interpretation with a zero range {delta}-interaction in a Nilsson basis gives reasonable agreement for Er-W but more significant discrepancies appear for Gd and Dy.« less
Gender interactions and success.
Wiggins, Carla; Peterson, Teri
2004-01-01
Does gender by itself, or does gender's interaction with career variables, better explain the difference between women and men's careers in healthcare management? US healthcare managers were surveyed regarding career and personal experiences. Gender was statistically interacted with explanatory variables. Multiple regression with backwards selection systematically removed non-significant variables. All gender interaction variables were non-significant. Much of the literature proposes that work and career factors impact working women differently than working men. We find that while gender alone is a significant predictor of income, it does not significantly interact with other career variables.
Lee, Young Kwang; Kim, Sungi; Nam, Jwa-Min
2015-01-12
Observation of single plasmonic nanoparticles in reconstituted biological systems allows us to obtain snapshots of dynamic processes between molecules and nanoparticles with unprecedented spatiotemporal resolution and single-molecule/single-particle-level data acquisition. This Concept is intended to introduce nanoparticle-tethered supported lipid bilayer platforms that allow for the dynamic confinement of nanoparticles on a two-dimensional fluidic surface. The dark-field-based long-term, stable, real-time observation of freely diffusing plasmonic nanoparticles on a lipid bilayer enables one to extract a broad range of information about interparticle and molecular interactions throughout the entire reaction period. Herein, we highlight important developments in this context to provide ideas on how molecular interactions can be interpreted by monitoring dynamic behaviors and optical signals of laterally mobile nanoparticles. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Observation of prethermalization in long-range interacting spin chains
Neyenhuis, Brian; Zhang, Jiehang; Hess, Paul W.; Smith, Jacob; Lee, Aaron C.; Richerme, Phil; Gong, Zhe-Xuan; Gorshkov, Alexey V.; Monroe, Christopher
2017-01-01
Although statistical mechanics describes thermal equilibrium states, these states may or may not emerge dynamically for a subsystem of an isolated quantum many-body system. For instance, quantum systems that are near-integrable usually fail to thermalize in an experimentally realistic time scale, and instead relax to quasi-stationary prethermal states that can be described by statistical mechanics, when approximately conserved quantities are included in a generalized Gibbs ensemble (GGE). We experimentally study the relaxation dynamics of a chain of up to 22 spins evolving under a long-range transverse-field Ising Hamiltonian following a sudden quench. For sufficiently long-range interactions, the system relaxes to a new type of prethermal state that retains a strong memory of the initial conditions. However, the prethermal state in this case cannot be described by a standard GGE; it rather arises from an emergent double-well potential felt by the spin excitations. This result shows that prethermalization occurs in a broader context than previously thought, and reveals new challenges for a generic understanding of the thermalization of quantum systems, particularly in the presence of long-range interactions. PMID:28875166
Constraining the interaction between dark sectors with future HI intensity mapping observations
NASA Astrophysics Data System (ADS)
Xu, Xiaodong; Ma, Yin-Zhe; Weltman, Amanda
2018-04-01
We study a model of interacting dark matter and dark energy, in which the two components are coupled. We calculate the predictions for the 21-cm intensity mapping power spectra, and forecast the detectability with future single-dish intensity mapping surveys (BINGO, FAST and SKA-I). Since dark energy is turned on at z ˜1 , which falls into the sensitivity range of these radio surveys, the HI intensity mapping technique is an efficient tool to constrain the interaction. By comparing with current constraints on dark sector interactions, we find that future radio surveys will produce tight and reliable constraints on the coupling parameters.
Influence of depth of interaction upon the performance of scintillator detectors.
Brown, Mark S; Gundacker, Stefan; Taylor, Alaric; Tummeltshammer, Clemens; Auffray, Etiennette; Lecoq, Paul; Papakonstantinou, Ioannis
2014-01-01
The uncertainty in time of particle detection within a scintillator detector, characterised by the coincidence time resolution (CTR), is explored with respect to the interaction position within the scintillator crystal itself. Electronic collimation between two scintillator detectors is utilised to determine the CTR with depth of interaction (DOI) for different materials, geometries and wrappings. Significantly, no relationship between the CTR and DOI is observed within experimental error. Confinement of the interaction position is seen to degrade the CTR in long scintillator crystals by 10%.
Evidence for a strong sulfur-aromatic interaction derived from crystallographic data.
Zauhar, R J; Colbert, C L; Morgan, R S; Welsh, W J
2000-03-01
We have uncovered new evidence for a significant interaction between divalent sulfur atoms and aromatic rings. Our study involves a statistical analysis of interatomic distances and other geometric descriptors derived from entries in the Cambridge Crystallographic Database (F. H. Allen and O. Kennard, Chem. Design Auto. News, 1993, Vol. 8, pp. 1 and 31-37). A set of descriptors was defined sufficient in number and type so as to elucidate completely the preferred geometry of interaction between six-membered aromatic carbon rings and divalent sulfurs for all crystal structures of nonmetal-bearing organic compounds present in the database. In order to test statistical significance, analogous probability distributions for the interaction of the moiety X-CH(2)-X with aromatic rings were computed, and taken a priori to correspond to the null hypothesis of no significant interaction. Tests of significance were carried our pairwise between probability distributions of sulfur-aromatic interaction descriptors and their CH(2)-aromatic analogues using the Smirnov-Kolmogorov nonparametric test (W. W. Daniel, Applied Nonparametric Statistics, Houghton-Mifflin: Boston, New York, 1978, pp. 276-286), and in all cases significance at the 99% confidence level or better was observed. Local maxima of the probability distributions were used to define a preferred geometry of interaction between the divalent sulfur moiety and the aromatic ring. Molecular mechanics studies were performed in an effort to better understand the physical basis of the interaction. This study confirms observations based on statistics of interaction of amino acids in protein crystal structures (R. S. Morgan, C. E. Tatsch, R. H. Gushard, J. M. McAdon, and P. K. Warme, International Journal of Peptide Protein Research, 1978, Vol. 11, pp. 209-217; R. S. Morgan and J. M. McAdon, International Journal of Peptide Protein Research, 1980, Vol. 15, pp. 177-180; K. S. C. Reid, P. F. Lindley, and J. M. Thornton, FEBS
Mixtures of Strongly Interacting Bosons in Optical Lattices
DOE Office of Scientific and Technical Information (OSTI.GOV)
Buonsante, P.; Penna, V.; Giampaolo, S. M.
2008-06-20
We investigate the properties of strongly interacting heteronuclear boson-boson mixtures loaded in realistic optical lattices, with particular emphasis on the physics of interfaces. In particular, we numerically reproduce the recent experimental observation that the addition of a small fraction of {sup 41}K induces a significant loss of coherence in {sup 87}Rb, providing a simple explanation. We then investigate the robustness against the inhomogeneity typical of realistic experimental realizations of the glassy quantum emulsions recently predicted to occur in strongly interacting boson-boson mixtures on ideal homogeneous lattices.
Does Digital Game Interactivity Always Promote Self-Efficacy?
Lee, Yu-Hao
2015-11-01
Interactive digital games can promote self-efficacy by engaging players in enactive and observational learning. However, interactivity does not always lead to greater self-efficacy. Important constructs in social cognitive theory, such as performance outcome and perceived similarity, are often not accounted for in studies that have tested the effect of digital game interactivity on self-efficacy. This study assessed the effects of interactive digital games compared with passive digital games based on video comparison, a common experimental design used to test the effect of digital game interactivity on self-efficacy. In addition, this study also evaluated player performance and measured perceived similarity to the observed player. Findings suggested that in general, digital game interactivity predicted higher self-efficacy compared with noninteractive passive games. However, in the noninteractive conditions, the effects of performance on self-efficacy were moderated by perceived similarity between the observer and the observed player. When the observed player was perceived to be similar to the observer, the effects of performance on self-efficacy were comparable to the interactive game, but when the observed player was perceived as dissimilar to the observer, observing the dissimilar player failed to increase observer self-efficacy. Implications for interactivity manipulations and game developers are discussed.
Light weakly interacting massive particles
NASA Astrophysics Data System (ADS)
Gelmini, Graciela B.
2017-08-01
Light weakly interacting massive particles (WIMPs) are dark matter particle candidates with weak scale interaction with the known particles, and mass in the GeV to tens of GeV range. Hints of light WIMPs have appeared in several dark matter searches in the last decade. The unprecedented possible coincidence into tantalizingly close regions of mass and cross section of four separate direct detection experimental hints and a potential indirect detection signal in gamma rays from the galactic center, aroused considerable interest in our field. Even if these hints did not so far result in a discovery, they have had a significant impact in our field. Here we review the evidence for and against light WIMPs as dark matter candidates and discuss future relevant experiments and observations.
Iturralde, Esti; Margolin, Gayla; Spies Shapiro, Lauren A.
2012-01-01
This study investigated links between interparental conflict appraisals (specifically threat and self-blame), sibling relationship quality (positive and negative dimensions), and anxiety in sibling pairs comprised of an adolescent and a younger sibling close in age. Sibling relationship quality was measured through behavioral observation. Links between self-blame and anxiety were moderated by sibling relationship quality. In older siblings, positive behavior with a sibling was associated with an attenuated relation between self-blame and anxiety. A paradoxical moderating effect was found for negative interactions; for both younger and older siblings, a relation between self-blame and anxiety was weakened in the presence of sibling negativity. Results offered support for theorized benefits of sibling relationship quality in helping early adolescents adjust to conflict between parents. PMID:24244080
Zeng, Yi; Chen, Huashuai; Ni, Ting; Ruan, Rongping; Feng, Lei; Nie, Chao; Cheng, Lingguo; Li, Yang; Tao, Wei; Gu, Jun; Land, Kenneth C.; Yashin, Anatoli; Tan, Qihua; Yang, Ze; Bolund, Lars; Yang, Huanming; Hauser, Elizabeth; Willcox, D. Craig; Willcox, Bradley J.; Tian, Xiao-Li; Vaupel, James W.
2015-01-01
Logistic regression analysis based on data from 822 Han Chinese oldest old aged 92+ demonstrated that interactions between carrying FOXO1A-266 or FOXO3-310 or FOXO3-292 and tea drinking at around age 60 or at present time were significantly associated with lower risk of cognitive disability at advanced ages. Associations between tea drinking and reduced cognitive disability were much stronger among carriers of the genotypes of FOXO1A-266 or FOXO3-310 or FOXO3-292 compared with noncarriers, and it was reconfirmed by analysis of three-way interactions across FOXO genotypes, tea drinking at around age 60, and at present time. Based on prior findings from animal and human cell models, we postulate that intake of tea compounds may activate FOXO gene expression, which in turn may positively affect cognitive function in the oldest old population. Our empirical findings imply that the health benefits of particular nutritional interventions, including tea drinking, may, in part, depend upon individual genetic profiles. PMID:24895270
NASA Astrophysics Data System (ADS)
Howard, Ward S.; Law, Nicholas M.; Ziegler, Carl A.; Baranec, Christoph; Riddle, Reed
2018-02-01
Adaptive optics laser guide-star systems perform atmospheric correction of stellar wavefronts in two parts: stellar tip-tilt and high-spatial-order laser correction. The requirement of a sufficiently bright guide star in the field-of-view to correct tip-tilt limits sky coverage. In this paper, we show an improvement to effective seeing without the need for nearby bright stars, enabling full sky coverage by performing only laser-assisted wavefront correction. We used Robo-AO, the first robotic AO system, to comprehensively demonstrate this laser-only correction. We analyze observations from four years of efficient robotic operation covering 15000 targets and 42000 observations, each realizing different seeing conditions. Using an autoguider (or a post-processing software equivalent) and the laser to improve effective seeing independent of the brightness of a target, Robo-AO observations show a 39% ± 19% improvement to effective FWHM, without any tip-tilt correction. We also demonstrate that 50% encircled energy performance without tip-tilt correction remains comparable to diffraction-limited, standard Robo-AO performance. Faint-target science programs primarily limited by 50% encircled energy (e.g., those employing integral field spectrographs placed behind the AO system) may see significant benefits to sky coverage from employing laser-only AO.
Experimental evidence of solitary wave interaction in Hertzian chains
NASA Astrophysics Data System (ADS)
Santibanez, Francisco; Munoz, Romina; Caussarieu, Aude; Job, Stéphane; Melo, Francisco
2011-08-01
We study experimentally the interaction between two solitary waves that approach one another in a linear chain of spheres interacting via the Hertz potential. When these counterpropagating waves collide, they cross each other and a phase shift in respect to the noninteracting waves is introduced as a result of the nonlinear interaction potential. This observation is well reproduced by our numerical simulations and is shown to be independent of viscoelastic dissipation at the bead contact. In addition, when the collision of equal amplitude and synchronized counterpropagating waves takes place, we observe that two secondary solitary waves emerge from the interacting region. The amplitude of the secondary solitary waves is proportional to the amplitude of incident waves. However, secondary solitary waves are stronger when the collision occurs at the middle contact in chains with an even number of beads. Although numerical simulations correctly predict the existence of these waves, experiments show that their respective amplitudes are significantly larger than predicted. We attribute this discrepancy to the rolling friction at the bead contact during solitary wave propagation.
Interactive Whiteboards: A New Tool for Extension Education
ERIC Educational Resources Information Center
Schroeder, Mary M.; Burns, Connie S.; Reicks, Marla M.
2011-01-01
Use of interactive whiteboards (IWBs) in school classrooms and conference rooms is increasing. To evaluate the effectiveness of IWBs as a tool for Extension education, two groups of 3rd and 4th grade Minnesota students (n=325) were taught nutrition using traditional methods or IWBs. Significant increases in knowledge and behavior were observed in…
A Chandra observation of the interacting pair of galaxies NGC 4485/4490
NASA Astrophysics Data System (ADS)
Roberts, T. P.; Warwick, R. S.; Ward, M. J.; Murray, S. S.
2002-12-01
We report the results of a 20-ks Chandra ACIS-S observation of the galaxy pair NGC 4485/4490. This is an interacting system containing a late-type spiral with an enhanced star formation rate (NGC 4490), and an irregular companion that possesses a disturbed morphology. A total of 29 discrete X-ray sources are found coincident with NGC 4490, but only one is found within NGC 4485. The sources range in observed X-ray luminosity from ~2 × 1037 to 4 × 1039 erg s-1. The more luminous sources appear, on average, to be spectrally harder than the fainter sources, an effect that is attributable to increased absorption in their spectra. Extensive diffuse X-ray emission is detected coincident with the disc of NGC 4490, and in the tidal tail of NGC 4485, which appears to be thermal in nature and hence the signature of a hot interstellar medium in both galaxies. However, the diffuse component accounts for only ~10 per cent of the total X-ray luminosity of the system (2 × 1040 erg s-1, 0.5-8 keV), which arises predominantly in a handful of the brightest discrete sources. This diffuse emission fraction is unusually low for a galaxy pair which has many characteristics that would lead it to be classified as a starburst system, possibly as a consequence of the small gravitational potential well of the system. The discrete source population, on the other hand, is similar to that observed in other starburst systems, possessing a flat luminosity function slope of ~-0.6 and a total of six ultraluminous X-ray sources (ULX). Five of the ULX are identified as probable black hole X-ray binary systems, and the sixth (which is coincident with a radio continuum source) is identified as an X-ray luminous supernova remnant. The ULX all lie in star formation regions, providing further evidence of the link between the ULX phenomenon and active star formation. Importantly, this shows that even in star-forming regions, the ULX population is dominated by accreting systems. We discuss the
NASA Astrophysics Data System (ADS)
Goldstein, A. H.; Isaacman, G. A.; Misztal, P. K.; Yee, L.; Olson, K. F.; Moss, J.; Kreisberg, N. M.; Hering, S. V.; Park, J. H.; Kaser, L.; Seco, R.; Guenther, A. B.; Su, L.; Mak, J. E.; Holzinger, R.; Hu, W.; Campuzano Jost, P.; Palm, B. B.; Day, D. A.; Jimenez, J. L.; Koss, A.; De Gouw, J. A.
2014-12-01
Our overarching goals in the SOAS 2013 campaign were to 1) quantify biogenic VOC emission and VOC deposition to understand the processes controlling these bi-directional exchanges, 2) observe a broad suite of primary VOC and their oxidation products in the field and in controlled laboratory experiments, and 3) investigate their fate to understand how anthropogenic pollution alters oxidation pathways and secondary organic aerosol (SOA) formation. We pursued these goals through measurement of atmospheric organics ranging from very volatile (using in-situ GC-MS and proton transfer reaction time-of-flight MS, PTR-ToF-MS) to semi-volatile gas and particle phase compounds (using the Semi-Volatile Thermal desorption Aerosol Gas chromatograph, SV-TAG). Measured concentrations and fluxes of VOCs at the top of the SEARCH tower were coordinated with concentration gradients and fluxes at the AABC flux tower site, and vertical profiles using the Long-EZ aircraft to provide equivalent observations across sites. These results are informed through measurements using the same instrument during the FIXIT controlled laboratory oxidation study at CalTech that investigated oxidation pathways of BVOC with varying levels of anthropogenic pollutants. Measurements by SV-TAG of particle-phase and total gas-plus-particle-phase compounds at the SEARCH tower provide hourly quantification of semi-volatile compounds, including the oxidation products of measured VOCs. Derivatization of hydroxyl groups prior to GC analysis allows analysis of highly oxidized chemicals, including most known tracers. Methyl tetrols, an oxidation product of isoprene, had a significant day-time gas-phase component, and their abundance was strongly correlated with particle-phase sulfate, indicative of anthropogenic influence on the formation or partitioning processes. Similar observations of pinic acid (monterpene oxidation product) and many other BVOC oxidation products were made in both the gas and particle phases
Predicting Interactions between Common Dolphins and the Pole-and-Line Tuna Fishery in the Azores
Cruz, Maria João; Menezes, Gui; Machete, Miguel; Silva, Mónica A.
2016-01-01
Common dolphins (Delphinus delphis) are responsible for the large majority of interactions with the pole-and-line tuna fishery in the Azores but the underlying drivers remain poorly understood. In this study we investigate the influence of various environmental and fisheries-related factors in promoting the interaction of common dolphins with this fishery and estimate the resultant catch losses. We analysed 15 years of fishery and cetacean interaction data (1998–2012) collected by observers placed aboard tuna fishing vessels. Dolphins interacted in less than 3% of the fishing events observed during the study period. The probability of dolphin interaction varied significantly between years with no evident trend over time. Generalized additive modeling results suggest that fishing duration, sea surface temperature and prey abundance in the region were the most important factors explaining common dolphin interaction. Dolphin interaction had no impact on the catches of albacore, skipjack and yellowfin tuna but resulted in significantly lower catches of bigeye tuna, with a predicted median annual loss of 13.5% in the number of fish captured. However, impact on bigeye catches varied considerably both by year and fishing area. Our work shows that rates of common dolphin interaction with the pole-and-line tuna fishery in the Azores are low and showed no signs of increase over the study period. Although overall economic impact was low, the interaction may lead to significant losses in some years. These findings emphasize the need for continued monitoring and for further research into the consequences and economic viability of potential mitigation measures. PMID:27851763
Predicting Interactions between Common Dolphins and the Pole-and-Line Tuna Fishery in the Azores.
Cruz, Maria João; Menezes, Gui; Machete, Miguel; Silva, Mónica A
2016-01-01
Common dolphins (Delphinus delphis) are responsible for the large majority of interactions with the pole-and-line tuna fishery in the Azores but the underlying drivers remain poorly understood. In this study we investigate the influence of various environmental and fisheries-related factors in promoting the interaction of common dolphins with this fishery and estimate the resultant catch losses. We analysed 15 years of fishery and cetacean interaction data (1998-2012) collected by observers placed aboard tuna fishing vessels. Dolphins interacted in less than 3% of the fishing events observed during the study period. The probability of dolphin interaction varied significantly between years with no evident trend over time. Generalized additive modeling results suggest that fishing duration, sea surface temperature and prey abundance in the region were the most important factors explaining common dolphin interaction. Dolphin interaction had no impact on the catches of albacore, skipjack and yellowfin tuna but resulted in significantly lower catches of bigeye tuna, with a predicted median annual loss of 13.5% in the number of fish captured. However, impact on bigeye catches varied considerably both by year and fishing area. Our work shows that rates of common dolphin interaction with the pole-and-line tuna fishery in the Azores are low and showed no signs of increase over the study period. Although overall economic impact was low, the interaction may lead to significant losses in some years. These findings emphasize the need for continued monitoring and for further research into the consequences and economic viability of potential mitigation measures.
Observations and initial modeling of lava-SO2 interactions at Prometheus, Io
NASA Astrophysics Data System (ADS)
Milazzo, M. P.; Keszthelyi, L. P.; McEwen, A. S.
2001-12-01
We present observations and initial modeling of the lava-SO2 interactions at the flow fronts in the Prometheus region of Io. Recent high-resolution observations of Prometheus reveal a compound flow field with many active flow lobes. Many of the flow lobes are associated with bright streaks of what is interpreted to be volatilized and recondensed SO2 radiating away from the hot lava. Lower-resolution color data show diffuse blue to violet areas, also near the active flow front, perhaps from active venting of SO2. Not clearly visible in any of the images is a single source vent for the active plume. While the size of the proposed vent is probably near the limit of the resolution, we expected to see radial or concentric albedo patterns or other evidence for gas and entrained particles above the flow field. The lack of an obvious plume vent, earlier suggestions that the Prometheus-type plumes may originate from the advancing flow lobes, and the high-resolution images showing evidence for large-scale volatilization of the SO2-rich substrate at Prometheus encouraged us to develop a model to quantify the heat transfer between a basaltic lava flow and a substrate of SO2 snow. We calculate that the vaporization rate of SO2 snow is 2.5×10-6ms-1 per unit area. Using an estimated 5 m2s-1 lava coverage rate (from change detection images), we show that the gas production rate of SO2 at the flow fronts is enough to produce a resurfacing rate of ~0.24 cm yr-1 at the annulus of Prometheus. This is much less than other estimates of resurfacing by the Prometheus plume. While not easily explaining the main Prometheus plume, our model readily accounts for the bright streaks.
Barker, Hannah Ruth; Griffiths, Peter; Mesa-Eguiagaray, Ines; Pickering, Ruth; Gould, Lisa; Bridges, Jackie
2016-10-01
The quality of staff-patient interactions underpins the overall quality of patient experience and can affect other important outcomes. However no studies have been identified that comprehensively explore both the quality and quantity of interactions in general hospital settings. To quantify and characterise the quality of staff-patient interactions and to identify factors associated with negative interaction ratings. Data were gathered at two acute English NHS hospitals between March and April 2015. Six wards for adult patients participated including medicine for older people (n=4), urology (n=1) and orthopaedics (n=1). Eligible patients on participating wards were randomly selected for observation. Staff-patient interactions were observed using the Quality of Interactions Schedule. 120h of care were observed with each 2h observation session determined from a balanced random schedule (Monday-Friday, 08:00-22:00h). Multilevel logistic regression models were used to determine factors associated with negative interactions. 1554 interactions involving 133 patients were observed. The median length of interaction was 36s with a mean of 6 interactions per patient per hour. Seventy three percent of interactions were categorized as positive, 17% neutral and 10% negative. Forty percent of patients had at least one negative interaction (95% confidence interval 32% to 49%). Interactions initiated by the patient (adjusted Odds Ratio [OR] 5.30), one way communication (adjusted OR 10.70), involving two or more staff (adjusted OR 5.86 for 2 staff, 6.46 for 3+ staff), having a higher total number of interactions (adjusted OR 1.09 per unit increase), and specific types of interaction content were associated with increased odds of negative interaction (p<0.05). In the full multivariable model there was no significant association with staff characteristics, skill mix or staffing levels. Patient agitation at the outset of interaction was associated with increased odds of negative
Influence of Depth of Interaction upon the Performance of Scintillator Detectors
Brown, Mark S.; Gundacker, Stefan; Taylor, Alaric; Tummeltshammer, Clemens; Auffray, Etiennette; Lecoq, Paul; Papakonstantinou, Ioannis
2014-01-01
The uncertainty in time of particle detection within a scintillator detector, characterised by the coinci- dence time resolution (CTR), is explored with respect to the interaction position within the scintillator crystal itself. Electronic collimation between two scintillator detectors is utilised to determine the CTR with depth of interaction (DOI) for different materials, geometries and wrappings. Significantly, no rela- tionship between the CTR and DOI is observed within experimental error. Confinement of the interaction position is seen to degrade the CTR in long scintillator crystals by 10%. PMID:24875832
Shi, Jinlei; Wu, Jinghe; Zhao, Xingju; ...
2016-10-07
Transitional metal nanoparticles or atoms deposited on appropriate substrates can lead to highly economical, efficient, and selective catalysis. One of the greatest challenges is to control the electronic metal–support interactions (EMSI) between the supported metal atoms and the substrate so as to optimize their catalytic performance. Here, from first-principles calculations, we show that an otherwise inactive Pd single adatom on TiO 2(110) can be tuned into a highly effective catalyst, e.g. for O 2 adsorption and CO oxidation, by purposefully selected metal–nonmetal co-dopant pairs in the substrate. Such an effect is proved here to result unambiguously from a significantly enhancedmore » EMSI. A nearly linear correlation is noted between the strength of the EMSI and the activation of the adsorbed O 2 molecule, as well as the energy barrier for CO oxidation. Particularly, the enhanced EMSI shifts the frontier orbital of the deposited Pd atom upward and largely enhances the hybridization and charge transfer between the O 2 molecule and the Pd atom. Upon co-doping, the activation barrier for CO oxidation on the Pd monomer is also reduced to a level comparable to that on the Pd dimer which was experimentally reported to be highly efficient for CO oxidation. The present findings provide new insights into the understanding of the EMSI in heterogeneous catalysis and can open new avenues to design and fabricate cost-effective single-atom-sized and/or nanometer-sized catalysts.« less
After Early Autism Diagnosis: Changes in Intervention and Parent-Child Interaction.
Suma, Katharine; Adamson, Lauren B; Bakeman, Roger; Robins, Diana L; Abrams, Danielle N
2016-08-01
This study documents the relation between an autism spectrum disorder (ASD) diagnosis, increases in intervention, and changes in parent-child interaction quality. Information about intervention and observations of interaction were collected before diagnosis and a half year after diagnosis for 79 low-risk toddlers who had screened positive for ASD risk during a well-baby checkup. Children diagnosed with ASD (n = 44) were 2.69 times more likely to increase intervention hours. After ASD diagnosis, the relation between intervention and interaction quality was complex: although increases in intervention and interaction quality were only modestly related, the overall amount of intervention after diagnosis was associated with higher quality interactions. Moreover, lower quality interactions before diagnosis significantly increased the likelihood that intervention would increase post-diagnosis.
Observation of Dipolar Spin-Exchange Interactions with Polar Molecules in a Lattice
2013-01-01
extend beyond nearest neighbours. This allows coherent spin dynamics to persist even for gases with relatively high entropy and low lattice filling...dynamics to persist even for gases with relatively high entropy and low lat- tice filling. While measured effects of dipolar interactions in ultracold...limits superexchange to nearest-neighbor interactions and requires extremely low temperature and entropy . In contrast, long-range dipolar
Direct observation of nanoparticle-cancer cell nucleus interactions.
Dam, Duncan Hieu M; Lee, Jung Heon; Sisco, Patrick N; Co, Dick T; Zhang, Ming; Wasielewski, Michael R; Odom, Teri W
2012-04-24
We report the direct visualization of interactions between drug-loaded nanoparticles and the cancer cell nucleus. Nanoconstructs composed of nucleolin-specific aptamers and gold nanostars were actively transported to the nucleus and induced major changes to the nuclear phenotype via nuclear envelope invaginations near the site of the construct. The number of local deformations could be increased by ultrafast, light-triggered release of the aptamers from the surface of the gold nanostars. Cancer cells with more nuclear envelope folding showed increased caspase 3 and 7 activity (apoptosis) as well as decreased cell viability. This newly revealed correlation between drug-induced changes in nuclear phenotype and increased therapeutic efficacy could provide new insight for nuclear-targeted cancer therapy.
Cloutier, Marie-Soleil; Lachapelle, Ugo; d'Amours-Ouellet, Andrée-Anne; Bergeron, Jacques; Lord, Sébastien; Torres, Juan
2017-07-01
Because pedestrian crash rates remain lower than other collision types, surrogate measures such as traffic interactions are now used in road safety research to complement crash history. Using naturalistic data collection, we sought to assess 1) the likelihood of occurrence of interactions between pedestrians and vehicles based on individual and crossing characteristics; and 2) differences in interaction characteristics between children, adult and senior pedestrians. Observations of pedestrian crossing behaviours (n=4687) were recorded at 278 crossings. For recorded interactions (n=843), information was collected to characterize the behaviours of involved parties. A mixed-effect logit regression model was performed to assess the factors associated with interactions. Chi-square tests evaluated differences between age groups and characteristics of observed interactions. Older adults were those more likely to be involved in an interaction event. Bicycle paths, different crossing surface material and one-way streets were significantly associated with fewer interactions with vehicles, while parked vehicles nearby and crossings on arterial roads were significantly associated with more interactions. Children and the elderly (80 years of age or more) did have distinct patterns of interaction, with more careful drivers/cyclists behaviours being observed towards children and lesser regulation compliance towards the elderly. Given the growing emphasis and adoption of active transportation in many cities, the number of interactions between pedestrians and vehicles during street crossings is likely to increase. Educating drivers and pedestrians to respect each other's space requires an understanding of where, between whom, and under what circumstances interactions occur. Such an approach can also help identify which engineering and enforcement programs are needed to ensure safe pedestrian crossings since interactions can be good markers of uncomfortable crossing situations that
Hazard Interactions and Interaction Networks (Cascades) within Multi-Hazard Methodologies
NASA Astrophysics Data System (ADS)
Gill, Joel; Malamud, Bruce D.
2016-04-01
Here we combine research and commentary to reinforce the importance of integrating hazard interactions and interaction networks (cascades) into multi-hazard methodologies. We present a synthesis of the differences between 'multi-layer single hazard' approaches and 'multi-hazard' approaches that integrate such interactions. This synthesis suggests that ignoring interactions could distort management priorities, increase vulnerability to other spatially relevant hazards or underestimate disaster risk. We proceed to present an enhanced multi-hazard framework, through the following steps: (i) describe and define three groups (natural hazards, anthropogenic processes and technological hazards/disasters) as relevant components of a multi-hazard environment; (ii) outline three types of interaction relationship (triggering, increased probability, and catalysis/impedance); and (iii) assess the importance of networks of interactions (cascades) through case-study examples (based on literature, field observations and semi-structured interviews). We further propose visualisation frameworks to represent these networks of interactions. Our approach reinforces the importance of integrating interactions between natural hazards, anthropogenic processes and technological hazards/disasters into enhanced multi-hazard methodologies. Multi-hazard approaches support the holistic assessment of hazard potential, and consequently disaster risk. We conclude by describing three ways by which understanding networks of interactions contributes to the theoretical and practical understanding of hazards, disaster risk reduction and Earth system management. Understanding interactions and interaction networks helps us to better (i) model the observed reality of disaster events, (ii) constrain potential changes in physical and social vulnerability between successive hazards, and (iii) prioritise resource allocation for mitigation and disaster risk reduction.
ERIC Educational Resources Information Center
Wang, Yan Z.; Wiley, Angela R.; Zhou, Xiaobin
2007-01-01
This study used a mixed methodology to investigate reliability, validity, and analysis level with Chinese immigrant observational data. European-American and Chinese coders quantitatively rated 755 minutes of Chinese immigrant parent-toddler dinner interactions on parental sensitivity, intrusiveness, detachment, negative affect, positive affect,…
NASA Astrophysics Data System (ADS)
Tanimoto, Jun
2014-05-01
In 2 × 2 prisoner’s dilemma games, network reciprocity is one mechanism for adding social viscosity, which leads to cooperative equilibrium. Here we show that combining the process for selecting a gaming partner with the process for selecting an adaptation partner significantly enhances cooperation, even though such selection processes require additional costs to collect further information concerning which neighbor should be chosen. Based on elaborate investigations of the dynamics generated by our model, we find that high levels of cooperation result from two kinds of behavior: cooperators tend to interact with cooperators to prevent being exploited by defectors and defectors tend to choose cooperators to exploit despite the possibility that some defectors convert to cooperators.
Whitton, Sarah W.; Waldinger, Robert J.; Schulz, Marc S.; Allen, Joseph P.; Crowell, Judith A.; Hauser, Stuart T.
2011-01-01
To test the social learning–based hypothesis that marital conflict resolution patterns are learned in the family of origin, longitudinal, observational data were used to assess prospective associations between family conflict interaction patterns during adolescence and offspring’s later marital conflict interaction patterns. At age 14 years, 47 participants completed an observed family conflict resolution task with their parents. In a subsequent assessment 17 years later, the participants completed measures of marital adjustment and an observed marital conflict interaction task with their spouse. As predicted, levels of hostility and positive engagement expressed by parents and adolescents during family interactions were prospectively linked with levels of hostility and positive engagement expressed by offspring and their spouses during marital interactions. Family-of-origin hostility was a particularly robust predictor of marital interaction behaviors; it predicted later marital hostility and negatively predicted positive engagement, controlling for psychopathology and family-of-origin positive engagement. For men, family-of-origin hostility also predicted poorer marital adjustment, an effect that was mediated through hostility in marital interactions. These findings suggest a long-lasting influence of family communication patterns, particularly hostility, on offspring’s intimate communication and relationship functioning. PMID:18410214
Nielsen, Stine L.; Fich, Lars B.; Roessler, Kirsten K.; Mullins, Michael F.
2017-01-01
ABSTRACT This article aims to understand patient wellbeing and satisfaction and to qualify the current guidelines for the application of art in hospitals. Employing anthropological methods, we focus on the interactional aspects of art in health interventions. A user-oriented study ranked 20 paintings, followed by an experiment using paintings in the dayroom of five medical wards. Fieldwork was done over a two-week period. During the first week, dayrooms were configured without the presence of art and in the second week were configured with the artworks. Semi-structured interviews, observation, participant observation and informal conversation were carried out and were informed by thermal cameras, which monitored the usage, patient occupation and flow in two of the dayrooms. The study shows that art contributes to creating an environment and atmosphere where patients can feel safe, socialize, maintain a connection to the world outside the hospital and support their identity. We conclude that the presence of visual art in hospitals contributes to health outcomes by improving patient satisfaction as an extended form of health care. The article draws attention to further research perspectives and methods associated with the development of art in hospitals. PMID:28452607
Nielsen, Stine L; Fich, Lars B; Roessler, Kirsten K; Mullins, Michael F
2017-12-01
This article aims to understand patient wellbeing and satisfaction and to qualify the current guidelines for the application of art in hospitals. Employing anthropological methods, we focus on the interactional aspects of art in health interventions. A user-oriented study ranked 20 paintings, followed by an experiment using paintings in the dayroom of five medical wards. Fieldwork was done over a two-week period. During the first week, dayrooms were configured without the presence of art and in the second week were configured with the artworks. Semi-structured interviews, observation, participant observation and informal conversation were carried out and were informed by thermal cameras, which monitored the usage, patient occupation and flow in two of the dayrooms. The study shows that art contributes to creating an environment and atmosphere where patients can feel safe, socialize, maintain a connection to the world outside the hospital and support their identity. We conclude that the presence of visual art in hospitals contributes to health outcomes by improving patient satisfaction as an extended form of health care. The article draws attention to further research perspectives and methods associated with the development of art in hospitals.
Mother-infant interaction at 12 months in prenatally cocaine-exposed children.
Ukeje, I; Bendersky, M; Lewis, M
2001-05-01
This study examined mother-infant interactions of 12-month-old African-American prenatally cocaine-exposed infants and their mothers. Videotaped observations were made during a free-play dyadic interaction, a brief separation, and a reunion period. Videotapes were coded for maternal and child behaviors during each phase of the procedure. Although there were few differences in interactive behaviors between prenatally cocaine-exposed and nonexposed children and their mothers, children who were prenatally exposed to cocaine ignored their mother's departure (odds ratio [OR] = 3.0, p < .05) during separation significantly more often than nonexposed subjects. In addition, mothers who abused cocaine engaged in significantly more verbal behavior (F(2,104) = 7.00, p < .001) with their children than mothers of nonexposed children. These findings indicate that women who used cocaine during pregnancy may not differ from nonusers in their interactions with their 12-month-old infants.
Hazard interactions and interaction networks (cascades) within multi-hazard methodologies
NASA Astrophysics Data System (ADS)
Gill, Joel C.; Malamud, Bruce D.
2016-08-01
This paper combines research and commentary to reinforce the importance of integrating hazard interactions and interaction networks (cascades) into multi-hazard methodologies. We present a synthesis of the differences between multi-layer single-hazard approaches and multi-hazard approaches that integrate such interactions. This synthesis suggests that ignoring interactions between important environmental and anthropogenic processes could distort management priorities, increase vulnerability to other spatially relevant hazards or underestimate disaster risk. In this paper we proceed to present an enhanced multi-hazard framework through the following steps: (i) description and definition of three groups (natural hazards, anthropogenic processes and technological hazards/disasters) as relevant components of a multi-hazard environment, (ii) outlining of three types of interaction relationship (triggering, increased probability, and catalysis/impedance), and (iii) assessment of the importance of networks of interactions (cascades) through case study examples (based on the literature, field observations and semi-structured interviews). We further propose two visualisation frameworks to represent these networks of interactions: hazard interaction matrices and hazard/process flow diagrams. Our approach reinforces the importance of integrating interactions between different aspects of the Earth system, together with human activity, into enhanced multi-hazard methodologies. Multi-hazard approaches support the holistic assessment of hazard potential and consequently disaster risk. We conclude by describing three ways by which understanding networks of interactions contributes to the theoretical and practical understanding of hazards, disaster risk reduction and Earth system management. Understanding interactions and interaction networks helps us to better (i) model the observed reality of disaster events, (ii) constrain potential changes in physical and social vulnerability
Zhou, P; Chou, J; Olea, R S; Yuan, J; Wagner, G
1999-09-28
Direct recruitment and activation of caspase-9 by Apaf-1 through the homophilic CARD/CARD (Caspase Recruitment Domain) interaction is critical for the activation of caspases downstream of mitochondrial damage in apoptosis. Here we report the solution structure of the Apaf-1 CARD domain and its surface of interaction with caspase-9 CARD. Apaf-1 CARD consists of six tightly packed amphipathic alpha-helices and is topologically similar to the RAIDD CARD, with the exception of a kink observed in the middle of the N-terminal helix. By using chemical shift perturbation data, the homophilic interaction was mapped to the acidic surface of Apaf-1 CARD centered around helices 2 and 3. Interestingly, a significant portion of the chemically perturbed residues are hydrophobic, indicating that in addition to the electrostatic interactions predicted previously, hydrophobic interaction is also an important driving force underlying the CARD/CARD interaction. On the basis of the identified functional residues of Apaf-1 CARD and the surface charge complementarity, we propose a model of CARD/CARD interaction between Apaf-1 and caspase-9.
NASA Astrophysics Data System (ADS)
Shao, Xin; Ai, Ni; Xu, Donghang; Fan, Xiaohui
2016-05-01
Human serum albumin (HSA) binding is one of important pharmacokinetic properties of drug, which is closely related to in vivo distribution and may ultimately influence its clinical efficacy. Compared to conventional drug, limited information on this transportation process is available for medicinal herbs, which significantly hampers our understanding on their pharmacological effects, particularly when herbs and drug are co-administrated as polytherapy to the ailment. Several lines of evidence suggest the existence of Salvia miltiorrhiza-Warfarin interaction. Since Warfarin is highly HSA bound in the plasma with selectivity to site I, it is critical to evaluate the possibility of HSA-related herb-drug interaction. Herein an integrated approach was employed to analyze the binding of chemicals identified in S. miltiorrhiza to HSA. Molecular docking simulations revealed filtering criteria for HSA site I compounds that include docking score and key molecular determinants for binding. For eight representative ingredients from the herb, their affinity and specificity to HSA site I was measured and confirmed fluorometrically, which helps to improve the knowledge of interaction mechanisms between this herb and HSA. Our results indicated that several compounds in S. miltiorrhiza were capable of decreasing the binding constant of Warfarin to HSA site I significantly, which may increase free drug concentration in vivo, contributing to the herb-drug interaction observed clinically. Furthermore, the significance of HSA mediated herb-drug interactions was further implied by manual mining on the published literatures on S. miltiorrhiza.
Fuchs, K.; Tittgemeyer, M.; Ryberg, T.; Wenzel, F.; Mooney, W.
2002-01-01
We infer the fine structure of a sub-Moho boundary layer (SMBL) at the top of the lithospheric mantle from high-resolution seismic observations of Peaceful Nuclear Explosions (PNE) on superlong-range profiles in Russia. Densely recorded seismograms permit recognition of previously unknown features of teleseismic propagation of the well known Pn and Sn phases, such as a band of incoherent, scattered, high-frequency seismic energy, developing consistently from station to station, apparent velocities of sub-Moho material, and high-frequency energy to distances of more than 3000 km with a coda band, incoherent at 10 km spacing and yet consistently observed to the end of the profiles. Estimates of the other key elements of the SMBL were obtained by finite difference calculations of wave propagation in elastic 2D models from a systematic grid search through parameter space. The SMBL consists of randomly distributed, mild velocity fluctuations of 2% or schlieren of high aspect ratios (???40) with long horizontal extent (???20 km) and therefore as thin as 0.5 km only; SMBL thickness is 60-100 km. It is suggested that the SMBL is of global significance as the physical base of the platewide observed high-frequency phases Pn and Sn. It is shown that wave propagation in the SMBL waveguide is insensitive to the background velocity distribution on which its schlieren are superimposed. This explains why the Pn and Sn phases traverse geological provinces of various age, heat flow, crustal thickness, and tectonic regimes. Their propagation appears to be independent of age. temperature, pressure, and stress. Dynamic stretching of mantle material during subduction or flow, possibly combined with chemical differentiation have to be considered as scale-forming processes in the upper mantle. However, it is difficult to distinguish with the present sets of Pn/Sn array data whether (and also where) the boundary layer is a frozen-in feature of paleo-processes or whether it is a response to
Enko, Jolanta; Gliszczyńska-Świgło, Anna
2015-01-01
Products containing natural additives, including antioxidants, are usually perceived by consumers as safer than those with synthetic ones. Natural antioxidants, besides having a preservative activity, may exert beneficial health effects. Interactions between antioxidants may significantly change their antioxidant activity, thus in designing functional foods or food/cosmetic ingredients knowledge about the type of interactions could be useful. In the present study, the interactions between ascorbic acid (AA; vitamin C) and different black and green tea extracts and the influence on their antioxidant activities were investigated. The antioxidant activities of tea extracts and their mixtures with AA prepared in several different weight ratios were measured using the trolox equivalent antioxidant capacity (TEAC), 1,1-diphenyl-2-picrylhydrazyl (DPPH), and ferric-reducing antioxidant power (FRAP) methods. The type of interaction was determined by interaction indexes and isobolograms. It was found that the weight ratio of extracts to AA significantly influenced the antioxidant activity of a mixture and the type of interaction between these components. The weight ratio of tea extract to AA can cause the change of interaction, e.g. from antagonism to additivism or from additivism to synergism. The observed differences in the type of interactions were probably also a result of different extracts' polyphenol composition and content. The type of interaction may also be affected by the medium in which extracts and AA interact, especially its pH and the solvent used. To obtain the best antioxidant effect, all these factors should be taken into account during the design of a tea extract-AA mixture.
Observational constraints on holographic tachyonic dark energy in interaction with dark matter
DOE Office of Scientific and Technical Information (OSTI.GOV)
Micheletti, Sandro M. R., E-mail: smrm@fma.if.usp.br
2010-05-01
We discuss an interacting tachyonic dark energy model in the context of the holographic principle. The potential of the holographic tachyon field in interaction with dark matter is constructed. The model results are compared with CMB shift parameter, baryonic acoustic oscilations, lookback time and the Constitution supernovae sample. The coupling constant of the model is compatible with zero, but dark energy is not given by a cosmological constant.
Measuring Team Learning Behaviours through Observing Verbal Team Interaction
ERIC Educational Resources Information Center
Raes, Elisabeth; Boon, Anne; Kyndt, Eva; Dochy, Filip
2015-01-01
Purpose: This study aims to explore, as an answer to the observed lack of knowledge about actual team learning behaviours, the characteristics of the actual observed basic team learning behaviours and facilitating team learning behaviours more in-depth of three project teams. Over time, team learning in an organisational context has been…
Direct Observation of Nanoparticle-Cancer Cell Nucleus Interactions
Dam, Duncan Hieu M.; Lee, Jung Heon; Sisco, Patrick N.; Co, Dick T.; Zhang, Ming; Wasielewski, Michael R.; Odom, Teri W.
2012-01-01
We report the direct visualization of interactions between drug-loaded nanoparticles and the cancer cell nucleus. Nanoconstructs composed of nucleolin-specific aptamers and gold nanostars were actively transported to the nucleus and induced major changes to the nuclear phenotype via nuclear envelope invaginations near the site of the construct. The number of local deformations could be increased by ultra-fast, light-triggered release of the aptamers from the surface of the gold nanostars. Cancer cells with more nuclear envelope folding showed increased caspase 3 and 7 activity (apoptosis) as well as decreased cell viability. This newly revealed correlation between drug-induced changes in nuclear phenotype and increased therapeutic efficacy could provide new insight for nuclear-targeted cancer therapy. PMID:22424173
Nanoscale light–matter interactions in atomic cladding waveguides
Stern, Liron; Desiatov, Boris; Goykhman, Ilya; Levy, Uriel
2013-01-01
Alkali vapours, such as rubidium, are being used extensively in several important fields of research such as slow and stored light nonlinear optics quantum computation, atomic clocks and magnetometers. Recently, there is a growing effort towards miniaturizing traditional centimetre-size vapour cells. Owing to the significant reduction in device dimensions, light–matter interactions are greatly enhanced, enabling new functionalities due to the low power threshold needed for nonlinear interactions. Here, taking advantage of the mature platform of silicon photonics, we construct an efficient and flexible platform for tailored light–vapour interactions on a chip. Specifically, we demonstrate light–matter interactions in an atomic cladding waveguide, consisting of a silicon nitride nano-waveguide core with a rubidium vapour cladding. We observe the efficient interaction of the electromagnetic guided mode with the rubidium cladding and show that due to the high confinement of the optical mode, the rubidium absorption saturates at powers in the nanowatt regime. PMID:23462991
Parent-Child Interactions, Peripheral Serotonin, and Self-Inflicted Injury in Adolescents
ERIC Educational Resources Information Center
Crowell, Sheila E.; Beauchaine, Theodore P.; McCauley, Elizabeth; Smith, Cindy J.; Vasilev, Christina A.; Stevens, Adrianne L.
2008-01-01
Self-inflicted injury in adolescence indicates significant emotional and psychological suffering. Although data on the etiology of self-injury are limited, current theories suggest that the emotional lability observed among self-injuring adolescents results from complex interactions between individual biological vulnerabilities and environmental…
NASA Astrophysics Data System (ADS)
Giampaolo, S. M.; Hiesmayr, B. C.; Illuminati, F.
2015-10-01
Frustration in quantum many-body systems is quantified by the degree of incompatibility between the local and global orders associated, respectively, with the ground states of the local interaction terms and the global ground state of the total many-body Hamiltonian. This universal measure is bounded from below by the ground-state bipartite block entanglement. For many-body Hamiltonians that are sums of two-body interaction terms, a further inequality relates quantum frustration to the pairwise entanglement between the constituents of the local interaction terms. This additional bound is a consequence of the limits imposed by monogamy on entanglement shareability. We investigate the behavior of local pair frustration in quantum spin models with competing interactions on different length scales and show that valence bond solids associated with exact ground state dimerization correspond to a transition from generic frustration, i.e., geometric, common to classical and quantum systems alike, to genuine quantum frustration, i.e., solely due to the noncommutativity of the different local interaction terms. We discuss how such frustration transitions separating genuinely quantum orders from classical-like ones are detected by observable quantities such as the static structure factor and the interferometric visibility.
Lunar Electric Fields: Observations and Implications
NASA Astrophysics Data System (ADS)
Halekas, J. S.; Delory, G. T.; Stubbs, T. J.; Farrell, W. M.; Vondrak, R. R.
2006-12-01
Alhough the Moon is typically thought of as having a relatively dormant environment, it is in fact very electrically active. The lunar surface, not protected by any substantial atmosphere, is directly exposed to solar UV and X-rays as well as solar wind plasma and energetic particles. This creates a complex electrodynamic environment, with the surface typically charging positive in sunlight and negative in shadow, and surface potentials varying over orders of magnitude in response to changing solar illumination and plasma conditions. Observations from the Apollo era and theoretical considerations strongly suggest that surface charging also drives dust electrification and horizontal and vertical dust transport. We present a survey of the lunar electric field environment, utilizing both newly interpreted Lunar Prospector (LP) orbital observations and older Apollo surface observations, and comparing to theoretical predictions. We focus in particular on time periods when the most significant surface charging was observed by LP - namely plasmasheet crossings (when the Moon is in the Earth's magnetosphere) and space weather events. During these time periods, kV-scale potentials are observed, and enhanced surface electric fields can be expected to drive significant horizontal and vertical dust transport. Both dust and electric fields can have serious effects on habitability and operation of machinery, so understanding the coupled dust-plasma-electric field system around the Moon is critically important for planning exploration efforts, in situ resource utilization, and scientific observations on the lunar surface. Furthermore, from a pure science perspective, this represents an excellent opportunity to study fundamental surface-plasma interactions.
Chow, Fung-Sing; Jusko, William J.
2014-01-01
Summary The immunosuppressive interactions of calcium channel antagonists [diltiazem (Dil), verapamil (Ver) and nifedipine (Nif)], with corticosteroids [methylprednisolone (Mpl), prednisolone (Prd)], and macrolides [tacrolimus (Tac) and sirolnnus (Sir)] were examined in human whole blood lymphocyte cultures. Gender-related differences in responses in the interactions between these drug classes were studied using blood from 6 males and 6 females. The nature and intensity of interactions were determined using an extended Loewe additivity model. All immunosuppressants exhibited higher potency than the calcium channel antagonists with mean IC50 values of: Dil (mM)Ver (mM)Nif (mM)Mpl (nM)Prd (nM)Tac (nM)Sir (nM)Male13541.921312.118.6150327Female11431.847.44.68.8111106 Gender-related differences in responses to Mpl and Prd were observed while the others were not significant. Additive interactions were found among calcium channel antagonists and corticosteroids. Significant synergistic interactions were observed between calcium channel antagonists and tacrolimus and sirolimus, although these are unlikely to be of clinical importance. These studies demonstrate diverse drug interactions in the examination of an important array of immunosuppressant drug combinations. PMID:15681895
Bruun, Emmi; Virta, Lauri J; Kälviäinen, Reetta; Keränen, Tapani
2017-08-01
A study was conducted to investigate the frequency of potential pharmacokinetic drug-to-drug interactions in elderly patients with newly diagnosed epilepsy. We also investigated co-morbid conditions associated with epilepsy. From the register of Kuopio University Hospital (KUH) we identified community-dwelling patients aged 65 or above with newly diagnosed epilepsy and in whom use of the first individual antiepileptic drug (AED) began in 2000-2013 (n=529). Furthermore, register data of the Social Insurance Institution of Finland were used for assessing potential interactions in a nationwide cohort of elderly subjects with newly diagnosed epilepsy. We extracted all patients aged 65 or above who had received special reimbursement for the cost of AEDs prescribed on account of epilepsy in 2012 where their first AED was recorded in 2011-2012 as monotherapy (n=1081). Clinically relevant drug interactions (of class C or D) at the time of starting of the first AED, as assessed via the SFINX-PHARAO database, were analysed. Hypertension (67%), dyslipidemia (45%), and ischaemic stroke (32%) were the most common co-morbid conditions in the hospital cohort of patients. In these patients, excessive polypharmacy (more than 10 concomitant drugs) was identified in 27% of cases. Of the patients started on carbamazepine, 52 subjects (32%) had one class-C or class-D drug interaction and 51 (31%) had two or more C- or D-class interactions. Only 2% of the subjects started on valproate exhibited a class-C interaction. None of the subjects using oxcarbazepine displayed class-C or class-D interactions. Patients with 3-5 (OR 4.22; p=0.05) or over six (OR 8.86; p=0.003) other drugs were more likely to have C- or D-class interaction. The most common drugs with potential interactions with carbamazepine were dihydropyridine calcium-blockers, statins, warfarin, and psychotropic drugs. Elderly patients with newly diagnosed epilepsy are at high risk of clinically relevant pharmacokinetic
Do native brown trout and non-native brook trout interact reproductively?
NASA Astrophysics Data System (ADS)
Cucherousset, J.; Aymes, J. C.; Poulet, N.; Santoul, F.; Céréghino, R.
2008-07-01
Reproductive interactions between native and non-native species of fish have received little attention compared to other types of interactions such as predation or competition for food and habitat. We studied the reproductive interactions between non-native brook trout ( Salvelinus fontinalis) and native brown trout ( Salmo trutta) in a Pyrenees Mountain stream (SW France). We found evidence of significant interspecific interactions owing to consistent spatial and temporal overlap in redd localizations and spawning periods. We observed mixed spawning groups composed of the two species, interspecific subordinate males, and presence of natural hybrids (tiger trout). These reproductive interactions could be detrimental to the reproduction success of both species. Our study shows that non-native species might have detrimental effects on native species via subtle hybridization behavior.
Important drug-nutrient interactions.
Mason, Pamela
2010-11-01
Drugs have the potential to interact with nutrients potentially leading to reduced therapeutic efficacy of the drug, nutritional risk or increased adverse effects of the drug. Despite significant interest in such interactions going back to over more than 40 years, the occurrence and clinical significance of many drug-nutrient interactions remains unclear. However, interactions involving drugs with a narrow therapeutic margin such as theophylline and digoxin and those that require careful blood monitoring such as warfarin are likely to be those of clinical significance. Drugs can affect nutrition as a result of changes in appetite and taste as well as having an influence on absorption or metabolism of nutrients. Moreover, foods and supplements can also interact with drugs, of which grapefruit juice and St John's wort are key examples. Significant numbers of people take both supplements and medication and are potentially at risk from interactions. Professionals, such as pharmacists, dietitians, nurses and doctors, responsible for the care of patients should therefore check whether supplements are being taken, while for researchers this is an area worthy of significant further study, particularly in the context of increasingly complex drug regimens and the plethora of new drugs.
Corticospinal excitability during the observation of social behavior.
Bucchioni, Giulia; Cavallo, Andrea; Ippolito, Davide; Marton, Gianluca; Castiello, Umberto
2013-03-01
Evidence suggests that the observation of an action induces in the observers an enhancement of motor evoked potentials (MEPs) recorded by the observer's muscles corresponding to those involved in the observed action. Although this is a well-studied phenomenon, it remains still unclear how the viewer's motor facilitation is influenced by the social content characterizing the observed scene. In the present study we investigated the facilitation of the corticospinal system during the observation of either an action that does not imply a social interaction (i.e., an actor throwing a ball against a wall), or an action which implies a social interaction (i.e., an actor passing a ball to a partner). Results indicate that MEPs amplitude is enhanced during the observation of a social rather than an individual action. We contend that the increase in MEPs activation might reflect an enhancement of the simulative activity stemming from the mirror system during the observation of social interactions. Altogether these findings show that the human corticospinal system is sensitive to social interactions and may support the role of the mirror neurons system in social cognition. Copyright © 2012 Elsevier Inc. All rights reserved.
Lennernäs, Hans
2009-01-01
Generally, gastric emptying of a drug to the small intestine is controlled by gastric motor activity and is the main factor affecting the onset of absorption. Accordingly, the emptying rate from the stomach is mainly affected by the digestive state, the properties of the pharmaceutical formulation and the effect of drugs, posture and circadian rhythm. Variability in the gastric emptying of drugs is reflected in variability in the absorption rate and the shape of the plasma pharmacokinetic profile. When ethanol interacts with an oral controlled release product, such that the mechanism controlling drug release is impaired, the delivery of the dissolved dose into the small intestine and the consequent absorption may result in dangerously high plasma concentrations. For example, the maximal plasma concentration of hydromorphone has individually been shown to be increased as much as 16 times through in vivo testing as a result of this specific pharmacokinetic ethanol-drug formulation interaction. Thus, a pharmacokinetic ethanol-drug interaction is a very serious safety concern when substantially the entire dose from a controlled release product is rapidly emptied into the small intestine (dose dumping), having been largely dissolved in a strong alcoholic beverage in the stomach during a sufficient lag-time in gastric emptying. Based on the literature, a two hour time frame for screening the in vitro dissolution profile of a controlled release product in ethanol concentrations of up to 40% is strongly supported and may be considered as the absolute minimum standard. It is also evident that the dilution, absorption and metabolism of ethanol in the stomach are processes with a minor effect on the local ethanol concentration and that ethanol exposure will be highly dependent on the volume and ethanol concentration of the fluid ingested, together with the rate of intake and gastric emptying. When and in which patients a clinically significant dose dumping will happen is
NASA Astrophysics Data System (ADS)
Guo, Juan-Juan; Zhang, Jing-Fei; Li, Yun-He; He, Dong-Ze; Zhang, Xin
2018-03-01
We consider the models of vacuum energy interacting with cold dark matter in this study, in which the coupling can change sigh during the cosmological evolution. We parameterize the running coupling b by the form b( a) = b 0 a+ b e(1- a), where at the early-time the coupling is given by a constant b e and today the coupling is described by another constant b 0. We explore six specific models with (i) Q = b( a) H 0 ρ 0, (ii) Q = b( a) H 0 ρ de, (iii) Q = b( a) H 0 ρ c, (iv) Q = b( a) Hρ 0, (v) Q = b( a) H ρ de, and (vi) Q = b( a) Hρ c. The current observational data sets we use to constrain the models include the JLA compilation of type Ia supernova data, the Planck 2015 distance priors data of cosmic microwave background observation, the baryon acoustic oscillations measurements, and the Hubble constant direct measurement. We find that, for all the models, we have b 0 < 0 and b e > 0 at around the 1 σ level, and b 0 and b e are in extremely strong anti-correlation. Our results show that the coupling changes sign during the evolution at about the 1 σ level, i.e., the energy transfer is from dark matter to dark energy when dark matter dominates the universe and the energy transfer is from dark energy to dark matter when dark energy dominates the universe.
ERIC Educational Resources Information Center
Curby, Timothy W.; Stuhlman, Megan; Grimm, Kevin; Mashburn, Andrew; Chomat-Mooney, Lia; Downer, Jason; Hamre, Bridget; Pianta, Robert C.
2011-01-01
The quality of classroom interactions has typically been studied using aggregates of ratings over time. However, within-day ratings may contain important variability. This study investigated within-day variability using the NICHD Study of Early Childcare and Youth Development's observational data during grades 3 and 5. The first question examined…
Human-directed social behaviour in dogs shows significant heritability.
Persson, M E; Roth, L S V; Johnsson, M; Wright, D; Jensen, P
2015-04-01
Through domestication and co-evolution with humans, dogs have developed abilities to attract human attention, e.g. in a manner of seeking assistance when faced with a problem solving task. The aims of this study were to investigate within breed variation in human-directed contact seeking in dogs and to estimate its genetic basis. To do this, 498 research beagles, bred and kept under standardized conditions, were tested in an unsolvable problem task. Contact seeking behaviours recorded included both eye contact and physical interactions. Behavioural data was summarized through a principal component analysis, resulting in four components: test interactions, social interactions, eye contact and physical contact. Females scored significantly higher on social interactions and physical contact and age had an effect on eye contact scores. Narrow sense heritabilities (h(2) ) of the two largest components were estimated at 0.32 and 0.23 but were not significant for the last two components. These results show that within the studied dog population, behavioural variation in human-directed social behaviours was sex dependent and that the utilization of eye contact seeking increased with age and experience. Hence, heritability estimates indicate a significant genetic contribution to the variation found in human-directed social interactions, suggesting that social skills in dogs have a genetic basis, but can also be shaped and enhanced through individual experiences. This research gives the opportunity to further investigate the genetics behind dogs' social skills, which could also play a significant part into research on human social disorders such as autism. © 2015 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.
Quality of social interaction in foster dyads at child age 2 and 3 years.
Jacobsen, Heidi; Vang, Kristin Alvestad; Lindahl, Karoline Mentzoni; Wentzel-Larsen, Tore; Smith, Lars; Moe, Vibeke
2018-06-30
The main aim of this study was to investigate the quality of social interaction between 60 foster parents and their foster children compared to a group of 55 non-foster families at 2 (T1) and again at 3 (T2) years of age. Video observations were used to investigate child-parent interaction at both time-points. "This is My Baby" interview was administered to investigate foster parents' commitment at T1. The main results revealed significant group differences at T1 on all child-parent social interaction measures, although not at T2. Further, a significant group by time interaction was identified for parental sensitivity, revealing a positive development over time in the foster group. Finally, a significant positive relation was found between commitment at T1 and parental sensitivity. The results convey an optimistic view of the possibilities for foster dyads to develop positive patterns of social interaction over time.
Decadal Air-Sea Interaction in the North Atlantic Based on Observations and Modeling Results
NASA Technical Reports Server (NTRS)
Hakkinen, Sirpa
1998-01-01
The decadal, 12-14 year, cycle observed in the North Atlantic SST and tide gauge data was examined using the NCEP/NCAR reanalyses, COADS data and an ocean model simulation. Besides this decadal mode, a shorter, subdecadal period of about 8 years exists in tide gauge data north of 40N, in the subpolar SST and in the winter North Atlantic Oscillation (NAO) index and in subpolar winter heat flux values. The decadal cycle is a well separated mode in a singular spectrum analysis (SSA) for a time series of SST EOF mode 1 with a center over the Gulf Stream extension. Tide gauge and SST data are consistent in that both show a significant subdecadal periodicity exclusively in the subpolar gyre, but in subtropics the 12-14 year period is the prominent, but nonstationary, decadal signal. The main finding of this study is that this 12-14 year cycle can be constructed based on the leading mode of the surface heat flux. This connection to the surface heat flux implicates the participation of the thermohaline circulation in the decadal cycle. During the cycle starting from the positive index phase of NAO, SST and oceanic heat content anomalies are created in subtropics due to local heat flux and intensification of the thermohaline circulation. The anomalies advect to the subpolar gyre where they are amplified by local heat flux and are part of the negative feedback of thermohaline circulation on itself. Consequently the oceanic thermohaline circulation slows down and the opposite cycle starts. The oscillatory nature would not be possible without the active atmospheric participation in the cycle, because it provides the unstable interaction through heat flux, without it, the oceanic mode would be damped. This analysis suggests that the two principal modes of heat flux variability, corresponding to patterns similar to North Atlantic Oscillation (NAO) and Western Atlantic (WA), are part of the same decadal cycle and an indirect measure of the north-south movement of the storm tracks.
Phosphorus-zinc interactive effects on growth by Selenastrum capricornutum (chlorophyta)
Kuwabara, J.S.
1985-01-01
Culturing experiments in chemically defined growth media were conducted to observe possible Zn and P interactions on Selenastrum capricornutum Printz growth indexes. Elevated Zn concentrations (7.5 ?? 10-8 and 1.5 ?? 10-7 M [Zn2+]) were highly detrimental to algal growth, affecting lag, exponential, and stationary growth phases. P behaved as a yield-limiting nutrient with maximum cell densities increasing linearly with total P. This yield limitation was intensified at elevated Zn concentrations. Although calculated cellular phosphorus concentrations increased markedly with Zn ion activity, elevated Zn concentrations had no apparent effect on rates of phosphorus uptake estimated for Selenastrum during exponential growth. Results indicated that P-Zn interactions were significant in describing Selenastrum cell yield results and are consistent with previous Zn studies on chlorophytes. These P-Zn interactions and the observed inhibitory growth effects of submicromolar Zn concentrations suggest that in nature an apparent P yield-limiting condition may result from elevated Zn concentrations.
Harvard Observing Project (HOP): Undergraduate and graduate observing opportunities
NASA Astrophysics Data System (ADS)
Bieryla, Allyson; Newton, Elisabeth R.
2014-06-01
The Harvard Observing Project (HOP) engages undergraduate students in observational astronomy and gives graduate students extra teaching experience beyond their required teaching fellowships. This project offers students opportunities to see if they are interested in astronomy, introduces them to scientific research, and provides an opportunity for them to interact with graduate students in an informal setting. Observations are made using the 16” Clay Telescope atop the Science Center at Harvard University in Cambridge, MA. We have observed as part of the Pro-Am White dwarf Monitoring (PAWM) and Target Asteroids! projects, and most recently we have been monitoring SN2014J in the Messier 82 galaxy (see poster by M. McIntosh).
Evaluation of virtual environment as a form of interactive resuscitation exam
NASA Astrophysics Data System (ADS)
Leszczyński, Piotr; Charuta, Anna; Kołodziejczak, Barbara; Roszak, Magdalena
2017-10-01
There is scientific evidence confirming the effectiveness of e-learning within resuscitation, however, there is not enough research on modern examination techniques within the scope. The aim of the pilot research is to compare the exam results in the field of Advanced Life Support in a traditional (paper) and interactive (computer) form as well as to evaluate satisfaction of the participants. A survey was conducted which meant to evaluate satisfaction of exam participants. Statistical analysis of the collected data was conducted at a significance level of α = 0.05 using STATISTICS v. 12. Final results of the traditional exam (67.5% ± 15.8%) differed significantly (p < 0.001) from the results of the interactive exam (53.3% ± 13.7%). However, comparing the number of students who did not pass the exam (passing point at 51%), no significant differences (p = 0.13) were observed between the two types exams. The feedback accuracy as well as the presence of well-prepared interactive questions could influence the evaluation of satisfaction of taking part in the electronic test. Significant differences between the results of a traditional test and the one supported by Computer Based Learning system showed the possibility of achieving a more detailed competence verification in the field of resuscitation thanks to interactive solutions.
Social networks predict selective observation and information spread in ravens
Rubenstein, Daniel I.; Bugnyar, Thomas; Hoppitt, William; Mikus, Nace; Schwab, Christine
2016-01-01
Animals are predicted to selectively observe and learn from the conspecifics with whom they share social connections. Yet, hardly anything is known about the role of different connections in observation and learning. To address the relationships between social connections, observation and learning, we investigated transmission of information in two raven (Corvus corax) groups. First, we quantified social connections in each group by constructing networks on affiliative interactions, aggressive interactions and proximity. We then seeded novel information by training one group member on a novel task and allowing others to observe. In each group, an observation network based on who observed whose task-solving behaviour was strongly correlated with networks based on affiliative interactions and proximity. Ravens with high social centrality (strength, eigenvector, information centrality) in the affiliative interaction network were also central in the observation network, possibly as a result of solving the task sooner. Network-based diffusion analysis revealed that the order that ravens first solved the task was best predicted by connections in the affiliative interaction network in a group of subadult ravens, and by social rank and kinship (which influenced affiliative interactions) in a group of juvenile ravens. Our results demonstrate that not all social connections are equally effective at predicting the patterns of selective observation and information transmission. PMID:27493780
Monitoring interactions between red-cockaded woodpeckers and southern flying squirrels.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Risch, Thomas S; Loeb, Susan C
2004-12-31
Risch, Thomas S., and Susan C. Loeb. 2004. Monitoring interactions between red-cockaded woodpeckers and southern flying squirrels. In: Red-cockaded woodpecker; Road to Recovery. Proceedings of the 4th Red-cockaded woodpecker Symposium. Ralph Costa and Susan J. Daniels, eds. Savannah, Georgia. January, 2003. Chapter 8. Cavities, Cavity Trees, and Cavity Communities. Pp 504-505. Abstract: Although several studies have suggested that southern flying squirrels (Glaucomys volans) may have a significant negative impact on red-cockades woodpeckers (Picoides borealsi) (Loeb and Hooper 1997, Laves and Loeb 1999), the nature of the interactions between the species remains unclear. Particularly lacking are data that address if southernmore » flying squirrels directly usurp red-cockaded woodpecker s from cavities, or simply occupy cavities previously abandoned by red-cockaded woodpeckers. Ridley et al. (1997) observed the displacement of a red-cockaded woodpecker by a southern flying squirrel that was released after being captured. Observations of nocturnal displacements of red-cockaded woodpeckers by flying squirrels, however, are lacking. Due to the difficulty of observing interspecific interactions, determining the mechanisims by which flying squirrels impact red-cockaded woodpeckers is problematic.« less
Majumder, P; Choudhury, A; Banerjee, M; Lahiri, A; Bhattacharyya, N P
2007-08-01
To investigate the mechanism of increased expression of caspase-1 caused by exogenous Hippi, observed earlier in HeLa and Neuro2A cells, in this work we identified a specific motif AAAGACATG (- 101 to - 93) at the caspase-1 gene upstream sequence where HIPPI could bind. Various mutations in this specific sequence compromised the interaction, showing the specificity of the interactions. In the luciferase reporter assay, when the reporter gene was driven by caspase-1 gene upstream sequences (- 151 to - 92) with the mutation G to T at position - 98, luciferase activity was decreased significantly in green fluorescent protein-Hippi-expressing HeLa cells in comparison to that obtained with the wild-type caspase-1 gene 60 bp upstream sequence, indicating the biological significance of such binding. It was observed that the C-terminal 'pseudo' death effector domain of HIPPI interacted with the 60 bp (- 151 to - 92) upstream sequence of the caspase-1 gene containing the motif. We further observed that expression of caspase-8 and caspase-10 was increased in green fluorescent protein-Hippi-expressing HeLa cells. In addition, HIPPI interacted in vitro with putative promoter sequences of these genes, containing a similar motif. In summary, we identified a novel function of HIPPI; it binds to specific upstream sequences of the caspase-1, caspase-8 and caspase-10 genes and alters the expression of the genes. This result showed the motif-specific interaction of HIPPI with DNA, and indicates that it could act as transcription regulator.
NASA Astrophysics Data System (ADS)
Sherrer, Adam Thomas
A thermal boundary developed during the morning to early afternoon hours on 27 April as a result of rainfall evaporation and shading from reoccurring deep convection. This boundary propagated to the north during the late afternoon to evening hours. The presence of the boundary produced an area more conducive for the formation of strong violent tornadoes through several processes. These processes included the production of horizontally generated baroclinic vorticity, increased values in storm-relative helicity, and decreasing lifting condensation level heights. Five supercell storms formed near and/or propagated alongside this boundary. Supercells that interacted with this boundary typically produced significant tornadic damage over long distances. Two of these supercells formed to the south (warm) side of the boundary and produced a tornado prior to crossing to the north (cool) side of the boundary. These two storms exhibited changes in appearance, intensity, and structure. Two other supercells formed well south of the boundary. These two storms remained relatively weak until they interacted with the boundary. These storms then rapidly intensified and produced tornadoes. Supercells that formed well into the cool side of the boundary either did not produce tornadoes or the tornadoes were determined to be weak in nature.
Mass flow in interacting binaries observed in the ultraviolet
NASA Technical Reports Server (NTRS)
Kondo, Yoji
1989-01-01
Recent satellite observations of close binary systems show that practically all binaries exhibit evidence of mass flow and that, where the observations are sufficiently detailed, a fraction of the matter flowing out of the mass-losing component is accreted by the companion and the remainder is lost from the binary system. The mass flow is not conservative. During the phase of dynamic mass flow, the companion star becomes immersed in optically-thick plasma and the physical properties of that star elude close scrutiny.
Bayesian characterization of uncertainty in species interaction strengths.
Wolf, Christopher; Novak, Mark; Gitelman, Alix I
2017-06-01
Considerable effort has been devoted to the estimation of species interaction strengths. This effort has focused primarily on statistical significance testing and obtaining point estimates of parameters that contribute to interaction strength magnitudes, leaving the characterization of uncertainty associated with those estimates unconsidered. We consider a means of characterizing the uncertainty of a generalist predator's interaction strengths by formulating an observational method for estimating a predator's prey-specific per capita attack rates as a Bayesian statistical model. This formulation permits the explicit incorporation of multiple sources of uncertainty. A key insight is the informative nature of several so-called non-informative priors that have been used in modeling the sparse data typical of predator feeding surveys. We introduce to ecology a new neutral prior and provide evidence for its superior performance. We use a case study to consider the attack rates in a New Zealand intertidal whelk predator, and we illustrate not only that Bayesian point estimates can be made to correspond with those obtained by frequentist approaches, but also that estimation uncertainty as described by 95% intervals is more useful and biologically realistic using the Bayesian method. In particular, unlike in bootstrap confidence intervals, the lower bounds of the Bayesian posterior intervals for attack rates do not include zero when a predator-prey interaction is in fact observed. We conclude that the Bayesian framework provides a straightforward, probabilistic characterization of interaction strength uncertainty, enabling future considerations of both the deterministic and stochastic drivers of interaction strength and their impact on food webs.
Interactions between recreational drugs and antiretroviral agents.
Antoniou, Tony; Tseng, Alice Lin-In
2002-10-01
To summarize existing data regarding potential interactions between recreational drugs and drugs commonly used in the management of HIV-positive patients. Information was obtained via a MEDLINE search (1966-August 2002) using the MeSH headings human immunodeficiency virus, drug interactions, cytochrome P450, medication names commonly prescribed for the management of HIV and related opportunistic infections, and names of commonly used recreational drugs. Abstracts of national and international conferences, review articles, textbooks, and references of all articles were also reviewed. Literature on pharmacokinetic interactions was considered for inclusion. Pertinent information was selected and summarized for discussion. In the absence of specific data, prediction of potential clinically significant interactions was based on pharmacokinetic and pharmacodynamic properties. All protease inhibitors (PIs) and nonnucleoside reverse transcriptase inhibitors are substrates and potent inhibitors or inducers of the cytochrome P450 system. Many classes of recreational drugs, including benzodiazepines, amphetamines, and opioids, are also metabolized by the liver and can potentially interact with antiretrovirals. Controlled interaction studies are often not available, but clinically significant interactions have been observed in a number of case reports. Overdoses secondary to interactions between the "rave" drugs methylenedioxymethamphetamine (MDMA) or gamma-hydroxybutyrate (GHB) and PIs have been reported. PIs, particularly ritonavir, may also inhibit metabolism of amphetamines, ketamine, lysergic acid diethylmide (LSD), and phencyclidine (PCP). Case series and pharmacokinetic studies suggest that nevirapine and efavirenz induce methadone metabolism, which may lead to symptoms of opiate withdrawal. A similar interaction may exist between methadone and the PIs ritonavir and nelfinavir, although the data are less consistent. Opiate metabolism can be inhibited or induced by
Magnetic field effect on the Coulomb interaction of acceptors in semimagnetic quantum dot
NASA Astrophysics Data System (ADS)
Kalpana, P.; Merwyn, A.; Reuben, Jasper D.; Nithiananthi, P.; Jayakumar, K.
2015-06-01
The Coulomb interaction of holes in a Semimagnetic Cd1-xMnxTe / CdTe Spherical and Cubical Quantum Dot (SMQD) in a magnetic field is studied using variational approach in the effective mass approximation. Since these holes in QD show a pronounced collective behavior, while distinct single particle phenomena is suppressed, their interaction in confined potential becomes very significant. It has been observed that acceptor-acceptor interaction is more in cubical QD than in spherical QD which can be controlled by the magnetic field. The results are presented and discussed.
Fields, Margaret A.; Cole, Pamela M.; Maggi, Mirella C.
2016-01-01
We investigated the degree to which toddlers’ observed emotional states, toddlers’ temperamental traits, and their interaction accounted for variance in mothers’ and fathers’ parenting. Main effects of two emotional states (positive emotion and negative emotion), three temperamental traits (negative affectivity, effortful control, and surgency) as well as state-by-trait interactions, were examined in relation to parental sensitivity, positive affect, and negative affect. The hypothesis that toddlers’ temperamental traits would moderate the association between their observed emotional states and parenting was partially supported. Significant state-by-trait interactions were found in models predicting the probability that mothers and fathers expressed negative affect towards their toddlers. For parental sensitivity and positive affect, only main effects of temperament and/or emotion expression accounted for variance in parenting. PMID:28479643
Salazar-Badillo, Fatima Berenice; Sánchez-Rangel, Diana; Becerra-Flora, Alicia; López-Gómez, Miguel; Nieto-Jacobo, Fernanda; Mendoza-Mendoza, Artemio; Jiménez-Bremont, Juan Francisco
2015-10-01
Plants are associated with a wide range of microorganisms throughout their life cycle, and some interactions result on plant benefits. Trichoderma species are plant beneficial fungi that enhance plant growth and development, contribute to plant nutrition and induce defense responses. Nevertheless, the molecules involved in these beneficial effects still need to be identify. Polyamines are ubiquitous molecules implicated in plant growth and development, and in the establishment of plant microbe interactions. In this study, we assessed the polyamine profile in Arabidopsis plants during the interaction with Trichoderma virens and Trichoderma atroviride, using a system that allows direct plant-fungal contact or avoids their physical interaction (split system). The plantlets that grew in the split system exhibited higher biomass than the ones in direct contact with Trichoderma species. After 3 days of interaction, a significant decrease in Arabidopsis polyamine levels was observed in both systems (direct contact and split). After 5 days of interaction polyamine levels were increased. The highest levels were observed with T. atroviride (split system), and with T. virens (direct contact). The expression levels of Arabidopsis ADC1 and ADC2 genes during the interaction with the fungi were also assessed. We observed a time dependent regulation of ADC1 and ADC2 genes, which correlates with polyamine levels. Our data show an evident change in polyamine profile during Arabidopsis - Trichoderma interaction, accompanied by evident alterations in plant root architecture. Polyamines could be involved in the changes undergone by plant during the interaction with this beneficial fungus. Copyright © 2015 Elsevier Masson SAS. All rights reserved.
An interactive environment for the analysis of large Earth observation and model data sets
NASA Technical Reports Server (NTRS)
Bowman, Kenneth P.; Walsh, John E.; Wilhelmson, Robert B.
1994-01-01
Envision is an interactive environment that provides researchers in the earth sciences convenient ways to manage, browse, and visualize large observed or model data sets. Its main features are support for the netCDF and HDF file formats, an easy to use X/Motif user interface, a client-server configuration, and portability to many UNIX workstations. The Envision package also provides new ways to view and change metadata in a set of data files. It permits a scientist to conveniently and efficiently manage large data sets consisting of many data files. It also provides links to popular visualization tools so that data can be quickly browsed. Envision is a public domain package, freely available to the scientific community. Envision software (binaries and source code) and documentation can be obtained from either of these servers: ftp://vista.atmos.uiuc.edu/pub/envision/ and ftp://csrp.tamu.edu/pub/envision/. Detailed descriptions of Envision capabilities and operations can be found in the User's Guide and Reference Manuals distributed with Envision software.
The facing bias in biological motion perception: Effects of stimulus gender and observer sex.
Schouten, Ben; Troje, Nikolaus F; Brooks, Anna; van der Zwan, Rick; Verfaillie, Karl
2010-07-01
Under orthographic projection, biological motion point-light walkers offer no cues to the order of the dots in depth: Views from the front and from the back result in the very same stimulus. Yet observers show a bias toward seeing a walker facing the viewer (Vanrie, Dekeyser, & Verfaillie, 2004). Recently, we reported that this facing bias strongly depends on the gender of the walker (Brooks et al., 2008). The goal of the present study was, first, to examine the robustness of the effect by testing a much larger subject sample and, second, to investigate whether the effect depends on observer sex. Despite the fact that we found a significant effect of figure gender, we clearly failed to replicate the strong effect observed in the original study. We did, however, observe a significant interaction between figure gender and observer sex.
Measuring Attitudes That Bias Teacher Observation.
ERIC Educational Resources Information Center
Marston, Paul T.; Clements, Richard O.
It was hypothesized that individual differences in observer attitudes might affect the way observers code teacher behavior. A questionnaire assessing educational attitudes was given to 22 subjects who were trained on 3 classroom observation systems: the Flanders Interaction Analysis, the Classroom Observation Scales, and the Classroom Observation…
Saha, Sovan; Sengupta, Kaustav; Chatterjee, Piyali; Basu, Subhadip; Nasipuri, Mita
2017-09-23
Infection and disease progression is the outcome of protein interactions between pathogen and host. Pathogen, the role player of Infection, is becoming a severe threat to life as because of its adaptability toward drugs and evolutionary dynamism in nature. Identifying protein targets by analyzing protein interactions between host and pathogen is the key point. Proteins with higher degree and possessing some topologically significant graph theoretical measures are found to be drug targets. On the other hand, exceptional nodes may be involved in infection mechanism because of some pathway process and biologically unknown factors. In this article, we attempt to investigate characteristics of host-pathogen protein interactions by presenting a comprehensive review of computational approaches applied on different infectious diseases. As an illustration, we have analyzed a case study on infectious disease malaria, with its causative agent Plasmodium falciparum acting as 'Bait' and host, Homo sapiens/human acting as 'Prey'. In this pathogen-host interaction network based on some interconnectivity and centrality properties, proteins are viewed as central, peripheral, hub and non-hub nodes and their significance on infection process. Besides, it is observed that because of sparseness of the pathogen and host interaction network, there may be some topologically unimportant but biologically significant proteins, which can also act as Bait/Prey. So, functional similarity or gene ontology mapping can help us in this case to identify these proteins. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.
Polarization of Λ hyperons produced inclusively in v p andbar v p charged current interactions
NASA Astrophysics Data System (ADS)
Jones, G. T.; Kennedy, B. W.; O'Neale, S. W.; Böckmann, K.; Gebel, W.; Geich-Gimbel, C.; Nellen, B.; Cooper-Sarkar, A. M.; Grant, A.; Klein, H.; Morrison, D. R. O.; Schmid, P.; Wachsmuth, H.; Barnham, K. W. J.; Clayton, E. F.; Miller, D. B.; Mobayyen, M. M.; Villalobos-Baillie, O.; Aderholz, M.; Deck, L.; Schmitz, N.; Settles, R.; Wernhard, K. L.; Wittek, W.; Corrigan, G.; Myatt, G.; Radojicic, D.; Saitta, B.; Wells, J.
1985-03-01
Lambda hyperons from v p andbar v p charged current interactions have been analysed for polarization. A significant polarization is observed for Λ particles in the quasi-elastic region for both types of interactions. Part of this polarization is due to the decay of highly polarized Σ(1385) resonances. The results are compared with simple predictions of the quark parton model.
Discovery of interaction signatures in the Hickson Compact Group 88
NASA Astrophysics Data System (ADS)
Brosch, Noah
2015-08-01
I describe new observations of the Hickson Compact Group 88 (HCG88) obtained during the commissioning of a new telescope at the Wise Observatory. The observations that reach low surface brightness levels reveal a diffuse, ~20-kpc long low-surface-brightness tail emerging from the brightest component (NGC 6878) to the NW, and possibly a morphological abnormally in component B (NGC 6977). The N6878 tail could explain the asymmetry in this galaxy’s optical rotation curve. These findings show that significant interactions, including possible galactic cannibalism, have taken place in at least two galaxies of this group, contrary to previous claims that HCG88 is in a very early stage of interaction. This work emphasizes the surprisingly interesting results that can be obtained from deep imaging of interesting targets.
Diaz-Toledano, Rosa; Lozano, Gloria; Martinez-Salas, Encarnacion
2017-02-17
The genome of RNA viruses folds into 3D structures that include long-range RNA–RNA interactions relevant to control critical steps of the viral cycle. In particular, initiation of translation driven by the IRES element of foot-and-mouth disease virus is stimulated by the 3΄UTR. Here we sought to investigate the RNA local flexibility of the IRES element and the 3΄UTR in living cells. The SHAPE reactivity observed in vivo showed statistically significant differences compared to the free RNA, revealing protected or exposed positions within the IRES and the 3΄UTR. Importantly, the IRES local flexibility was modified in the presence of the 3΄UTR, showing significant protections at residues upstream from the functional start codon. Conversely, presence of the IRES element in cis altered the 3΄UTR local flexibility leading to an overall enhanced reactivity. Unlike the reactivity changes observed in the IRES element, the SHAPE differences of the 3΄UTR were large but not statistically significant, suggesting multiple dynamic RNA interactions. These results were supported by covariation analysis, which predicted IRES-3΄UTR conserved helices in agreement with the protections observed by SHAPE probing. Mutational analysis suggested that disruption of one of these interactions could be compensated by alternative base pairings, providing direct evidences for dynamic long-range interactions between these distant elements of the viral genome.
Wavelet analysis of particle density functions in nucleus-nucleus interactions
NASA Astrophysics Data System (ADS)
Manna, S. K.; Haldar, P. K.; Mali, P.; Mukhopadhyay, A.; Singh, G.
A continuous wavelet analysis is performed for pattern recognition of the pseudorapidity density profile of singly charged particles produced in 16O+Ag/Br and 32S+Ag/Br interactions, each at an incident energy of 200 GeV per nucleon in the laboratory system. The experiments are compared with a model prediction based on the ultra-relativistic quantum molecular dynamics (UrQMD). To eliminate the contribution coming from known source(s) of particle cluster formation like Bose-Einstein correlation (BEC), the UrQMD output is modified by “an algorithm that mimics the BEC as an after burner.” We observe that for both interactions particle clusters are found at same pseudorapidity locations at all scales. However, the cluster locations in the 16O+Ag/Br interaction are different from those found in the 32S+Ag/Br interaction. Significant differences between experiments and simulations are revealed in the wavelet pseudorapidity spectra that can be interpreted as the preferred pseudorapidity values and/or scales of the pseudorapidity interval at which clusters of particles are formed. The observed discrepancy between experiment and corresponding simulation should therefore be interpreted in terms of some kind of nontrivial dynamics of multiparticle production.
NASA Astrophysics Data System (ADS)
Burlaga, L. F.; Ness, N. F.; Belcher, J. W.; Szabo, A.; Isenberg, P. A.; Lee, M. A.
1994-11-01
Five pressure-balanced structures, each with a scale of the order of a few hundredths of an astonomical unit (AU), were identified in two merged interaction regions (MIRs) near 35 AU in the Voyager 2 plasma and magnetic field data. They include a tangential discontinuity, simple and complex magnetic holes, slow correlated variations among the plasma and magnetic field parameters, and complex uncorrelated variations among the parameters. The changes in the magnetic pressure in these events are balanced by changes in the pressure of interstellar pickup protons. Thus the pickup protons probably play a major role in the dynamics of the MIRs. The solar wind proton and electron pressures are relatively unimportant in the MIRs at 35 AU and beyond. The region near 35 AU is transition region: the Sun is the source of the magnetic field, but the interstellar medium in source of pickups protons. Relative to the solar wind proton guyroadius, the thicknesses of the discontinuities and simple magnetic holes observed near 35 AU are at least an order of magnitude greater than those observed at 1 AU. However, the thicknesses of the tangential discontinuity and simple magnetic holes observed near 35 AU (in units of the pickup proton Larmor radius) are comparable to those observed at 1 AU (in units of the solar wind proton gyroradius). Thus the gyroradius of interstellar pickup protons controls the thickness of current sheets near 35 AU. We determine the interstellar pickup proton pressure in the PBSs. Using a model for the pickup proton temperature, we estimate that the average interstellar pickup proton pressure, temperature, and density in the MIRs at 35 AU are (0.53 +/- 0.14) x 10-12 erg/cu cm, (5.8 +/- 0.4) x 106 K and (7 +/- 2) x 10-4/cu cm.
Tang, Hongwei; Wei, Peng; Duell, Eric J; Risch, Harvey A; Olson, Sara H; Bueno-de-Mesquita, H Bas; Gallinger, Steven; Holly, Elizabeth A; Petersen, Gloria M; Bracci, Paige M; McWilliams, Robert R; Jenab, Mazda; Riboli, Elio; Tjønneland, Anne; Boutron-Ruault, Marie Christine; Kaaks, Rudolf; Trichopoulos, Dimitrios; Panico, Salvatore; Sund, Malin; Peeters, Petra H M; Khaw, Kay-Tee; Amos, Christopher I; Li, Donghui
2014-01-01
Obesity and diabetes are potentially alterable risk factors for pancreatic cancer. Genetic factors that modify the associations of obesity and diabetes with pancreatic cancer have previously not been examined at the genome-wide level. Using genome-wide association studies (GWAS) genotype and risk factor data from the Pancreatic Cancer Case Control Consortium, we conducted a discovery study of 2,028 cases and 2,109 controls to examine gene-obesity and gene-diabetes interactions in relation to pancreatic cancer risk by using the likelihood-ratio test nested in logistic regression models and Ingenuity Pathway Analysis (IPA). After adjusting for multiple comparisons, a significant interaction of the chemokine signaling pathway with obesity (P = 3.29 × 10(-6)) and a near significant interaction of calcium signaling pathway with diabetes (P = 1.57 × 10(-4)) in modifying the risk of pancreatic cancer were observed. These findings were supported by results from IPA analysis of the top genes with nominal interactions. The major contributing genes to the two top pathways include GNGT2, RELA, TIAM1, and GNAS. None of the individual genes or single-nucleotide polymorphism (SNP) except one SNP remained significant after adjusting for multiple testing. Notably, SNP rs10818684 of the PTGS1 gene showed an interaction with diabetes (P = 7.91 × 10(-7)) at a false discovery rate of 6%. Genetic variations in inflammatory response and insulin resistance may affect the risk of obesity- and diabetes-related pancreatic cancer. These observations should be replicated in additional large datasets. A gene-environment interaction analysis may provide new insights into the genetic susceptibility and molecular mechanisms of obesity- and diabetes-related pancreatic cancer.
NASA Astrophysics Data System (ADS)
Chen, W.; Jiang, M.; Xu, Y.; Shi, P. W.; Yu, L. M.; Ding, X. T.; Shi, Z. B.; Ji, X. Q.; Yu, D. L.; Li, Y. G.; Yang, Z. C.; Zhong, W. L.; Qiu, Z. Y.; Li, J. Q.; Dong, J. Q.; Yang, Q. W.; Liu, Yi.; Yan, L. W.; Xu, M.; Duan, X. R.
2017-11-01
Multi-scale interactions have been observed recently in the HL-2A core NBI plasmas, including the synchronous coupling between m/n=1/1 kink mode and m/n=2/1 tearing mode, nonlinear couplings of TAE/BAE and m/n=2/1 TM near q=2 surface, AITG/KBM/BAE and m/n=1/1 kink mode near q=1 surface, and between m/n=1/1 kink mode and high-frequency turbulence. Experimental results suggest that several couplings can exist simultaneously, Alfvenic fluctuations have an important contribution to the high-frequency turbulence spectra, and the couplings reveal the electromagnetic character. Multi-scale interactions via the nonlinear modulation process maybe enhance plasma transport and trigger sawtooth-crash onset.
Electrophobic interaction induced impurity clustering in metals
DOE Office of Scientific and Technical Information (OSTI.GOV)
Zhou, Hong-Bo; Wang, Jin-Long; Jiang, W.
2016-10-01
We introduce the concept of electrophobic interaction, analogous to hydrophobic interaction, for describing the behavior of impurity atoms in a metal, a 'solvent of electrons'. We demonstrate that there exists a form of electrophobic interaction between impurities with closed electron shell structure, which governs their dissolution behavior in a metal. Using He, Be and Ar as examples, we predict by first-principles calculations that the electrophobic interaction drives He, Be or Ar to form a close-packed cluster with a clustering energy that follows a universal power-law scaling with the number of atoms (N) dissolved in a free electron gas, as wellmore » as W or Al lattice, as Ec is proportional to (N2/3-N). This new concept unifies the explanation for a series of experimental observations of close-packed inert-gas bubble formation in metals, and significantly advances our fundamental understanding and capacity to predict the solute behavior of impurities in metals, a useful contribution to be considered in future material design of metals for nuclear, metallurgical, and energy applications.« less
Young star clusters in the interacting galaxies of Hickson Compact Group 90
NASA Astrophysics Data System (ADS)
Miah, J. A.; Sharples, R. M.; Cho, J.
2015-03-01
Deep images of Hickson Compact Group 90 (HCG 90) have been obtained using the Advanced Camera for Surveys on the Hubble Space Telescope. We report results for star clusters observed in the interacting pair of galaxies NGC 7174 and NGC 7176. We present magnitude and colour distributions for the observed cluster population and find that the majority of objects show colours similar to intermediate/old age (>1 Gyr) globular clusters. However, a significant population of blue star clusters are also observed which may have formed from the tidal interaction currently occurring between the two galaxies. We find luminosity function turnover magnitudes of m^{TO}g = 25.1 ± 0.1 and m^{TO}z = 24.3 ± 0.1 for the g and z bands, respectively, implying distances of Dg = 28.8 ± 2.6 Mpc and Dz = 34.7 ± 3.1 Mpc to these galaxies, using the globular cluster luminosity function method. Lastly, we determine a total cluster population of approximately NGC ≃ 212 ± 10 over all magnitudes and a low specific frequency of SN ˜ 0.6 ± 0.1 for this pair of interacting elliptical and spiral galaxies. The small globular cluster population is likely due to tidal interactions taking place between the two galaxies which may have stripped many progenitor clusters away and formed the diffuse light observed at the core of HCG 90.
NASA Astrophysics Data System (ADS)
Clark, M.
2009-09-01
In the past, the physical presence and direct interaction of the astronomer with an observatory's staff and telescope equipment encouraged understanding and responsiveness between both staff and observers. But now, observatories often face the problem of expediently exchanging information with observers. New observatory procedures and policies such as automated-, remote- and service-observing, dynamic scheduling, data pipelining, or fully software-arbitrated telescope control provide for more efficient telescope use, but they have reduced the role of the observer to that of a customer rather than a partner in the process of observing. Topics for discussion will include scheduling, data quality, control interfaces, training and preparation for observing, and information distribution technologies, e.g., use of web sites, email, and RSS feeds.
Demand behavior and empathic accuracy in observed conflict interactions in couples.
Hinnekens, Céline; Ickes, William; Schryver, Maarten De; Verhofstadt, Lesley L
2016-01-01
The study reported in this research note sought to extend the research on motivated empathic accuracy by exploring whether intimate partners who are highly motivated to induce change in their partner during conflicts will be more empathically accurate than partners who are less motivated. In a laboratory experiment, the partners within 26 cohabiting couples were randomly assigned the role of conflict initiator. The partners provided questionnaire data, participated in a videotaped conflict interaction, and completed a video-review task. More blaming behavior was associated with higher levels of empathic accuracy, irrespective of whether one was the conflict initiator or not. The results also showed a two-way interaction indicating that initiators who applied more pressure on their partners to change were less empathically accurate than initiators who applied less pressure, whereas their partners could counter this pressure when they could accurately "read" the initiator's thoughts and feelings.
NASA Astrophysics Data System (ADS)
Ferragut, G.; Liu, T.; Klemperer, S. L.
2017-12-01
In recent years Virtual Deep Seismic Sounding (VDSS) emerged as a novel method to image the Moho, which uses the post-critical reflection P waves at the Moho generated by teleseismic S waves at the free surface near the receivers (SsPmp). However, observed SsPmp sometimes have significantly lower amplitude than predicted, raising doubts among the seismic community on the theoretical basis of the method. With over two decades of continuous digital broadband records and major subduction zones in the range of 30-50 degrees, the Yellowknife Array in northern Canada provides a rich opportunity for observation of post-critical SsPmp. We analyze S wave coda of events with epicenter distances of 30-50°, and pay special attention to earthquakes in a narrow azimuth range that encompasses the Kamchatka Peninsula. Among 21 events with strong direct S energy on the radial components, we observe significant variation of SsPmp energy. After associating the SsPmp energy with the virtual source location of each event, we observe a general trend of decreasing SsPmp energy from NE to SW. As the trend coincides with the transition from exposed basement of the Slave Craton to Paleozoic platform covered by Phanerozoic sediment, we interpret the decreasing SsPmp energy as a result of lower S velocity at the virtual sources, which reduces S-to-P reflection coefficients. We plan to include more events from the Aleutian Islands, the virtual sources of which are primarily located in the Paleozoic platform. This will allow us to further investigate the relationship between SsPmp amplitude and near-surface velocity.
Cooperative Interactions in Peer Tutoring: Patterns and Sequences in Paired Writing
ERIC Educational Resources Information Center
Duran, David
2010-01-01
The research analyzes the interaction of 24 students (12 pairs) of secondary students when using peer tutoring techniques to learn Catalan. Students worked together in a program to produce an authentic writing experience. Significant increases were observed in pre- and posttest Catalan attainment scores of students. An analysis of the…
Challenges in design of Kitaev materials: Magnetic interactions from competing energy scales
NASA Astrophysics Data System (ADS)
Winter, Stephen M.; Li, Ying; Jeschke, Harald O.; Valentí, Roser
2016-06-01
In this study, we reanalyze the magnetic interactions in the Kitaev spin-liquid candidate materials Na2IrO3,α -RuCl3 , and α -Li2IrO3 using nonperturbative exact diagonalization methods. These methods are more appropriate given the relatively itinerant nature of the systems suggested in previous works. We treat all interactions up to third neighbors on equal footing. The computed terms reveal significant long-range coupling, bond anisotropy, and/or off-diagonal couplings which we argue naturally explain the observed ordered phases in these systems. Given these observations, the potential for realizing the spin-liquid state in real materials is analyzed, and synthetic challenges are defined and explained.
NASA Astrophysics Data System (ADS)
Gassmöller, Rene; Steinberger, Bernhard; Dannberg, Juliane; Bredow, Eva; Torsvik, Trond
2015-04-01
Mantle plumes are thought to originate at thermal or thermo-chemical boundary layers, and since their origin is relatively fixed compared to plate motion they produce hotspot tracks at the position of their impingement. When plumes reach the surface close to mid-ocean ridges, they generate thicker oceanic crust due to their increased temperature and hence higher degree of melting. Observations of these thickness variations allow estimates about the buoyancy flux and excess temperature of the plume. One example is the interaction of the Tristan plume with the South Atlantic Mid-Ocean Ridge, however, conclusions about the plume properties are complicated by the fact that the Tristan plume track has both on- and off-ridge segments. In these cases, where a plume is overridden by a ridge, it is assumed that the plume flux has a lateral component towards the ridge (the plume is "captured" by the ridge). Additionally, sea floor spreading north of the Florianopolis Fracture Zone did not start until ~112 Ma - at least 15 Ma after the plume head arrival - while the Atlantic had already opened south of it. Therefore, the plume is influenced by the jump in lithosphere thickness across the Florianopolis Fracture zone. We present crustal thickness and plume tracks of a three-dimensional regional convection model of the upper mantle for the Tristan-South Atlantic ridge interaction. The model is created with the convection code ASPECT, which allows for adaptive finite-element meshes to resolve the fine-scale structures within a rising plume head in the presence of large viscosity variations. The boundary conditions of the model are prescribed from a coarser global mantle convection model and the results are compared against recently published models of crustal thickness in the South Atlantic and hotspot tracks in global moving hotspot reference frames. In particular, we investigate the influence of the overriding ridge on the plume head. Thus, our comparison between models of
NASA Astrophysics Data System (ADS)
Gassmoeller, R.; Dannberg, J.; Steinberger, B. M.; Bredow, E.; Torsvik, T. H.
2015-12-01
Mantle plumes are thought to originate at thermal or thermo-chemical boundary layers, and since their origin is relatively fixed compared to plate motion they produce hotspot tracks at the position of their impingement. When plumes reach the surface close to mid-ocean ridges, they generate thicker oceanic crust due to their increased temperature and hence higher degree of melting. Observations of these thickness variations allow estimates about the buoyancy flux and excess temperature of the plume. One example is the interaction of the Tristan plume with the South Atlantic Mid-Ocean Ridge, however, conclusions about the plume properties are complicated by the fact that the Tristan plume track has both on- and off-ridge segments. In these cases, where a plume is overridden by a ridge, it is assumed that the plume flux has a lateral component towards the ridge (the plume is "captured" by the ridge). Additionally, sea floor spreading north of the Florianopolis Fracture Zone did not start until 112 Ma -- at least 15 Ma after the plume head arrival -- while the Atlantic had already opened south of it. Therefore, the plume is influenced by the jump in lithosphere thickness across the Florianopolis Fracture zone.We present crustal thickness and plume tracks of a three-dimensional regional convection model of the upper mantle for the Tristan-South Atlantic ridge interaction. The model is created with the convection code ASPECT, which allows for adaptive finite-element meshes to resolve the fine-scale structures within a rising plume head in the presence of large viscosity variations. The boundary conditions of the model are prescribed from a coarser global mantle convection model and the results are compared against recently published models of crustal thickness in the South Atlantic and hotspot tracks in global moving hotspot reference frames. In particular, we investigate the influence of the overriding ridge on the plume head.Thus, our comparison between models of plume
Polarization observables in few nucleon systems with CLAS
DOE Office of Scientific and Technical Information (OSTI.GOV)
Zachariou, Nicholas
The CEBAF Large Acceptance Spectrometer (CLAS), housed in Hall-B at the Thomas Jefferson National Accelerator Facility provides us with the experimental tools to study strongly-interacting matter and its dynamics in the transition from hadronic to partonic degrees of freedom in nuclear interactions. In this paper we discuss the progress made in understanding the relevant degrees of freedom using polarisation observables of deuteron photodisintegration in the few-GeV photon-energy region. We also address progress made in studying the interaction between Hyperons and Nucleons via polarisation observables, utilising high-statistics experiments that provided us with the large data samples needed to study final-state interactions,more » as well as perform detailed studies on initial-state effects. The polarisation observables presented here provide us with unique experimental tools to study the underlying dynamics of both initial and final-state interactions, as well as the information needed to disentangle signal from background contributions.« less
Polarization observables in few nucleon systems with CLAS
Zachariou, Nicholas
2017-12-01
The CEBAF Large Acceptance Spectrometer (CLAS), housed in Hall-B at the Thomas Jefferson National Accelerator Facility provides us with the experimental tools to study strongly-interacting matter and its dynamics in the transition from hadronic to partonic degrees of freedom in nuclear interactions. In this paper we discuss the progress made in understanding the relevant degrees of freedom using polarisation observables of deuteron photodisintegration in the few-GeV photon-energy region. We also address progress made in studying the interaction between Hyperons and Nucleons via polarisation observables, utilising high-statistics experiments that provided us with the large data samples needed to study final-state interactions,more » as well as perform detailed studies on initial-state effects. The polarisation observables presented here provide us with unique experimental tools to study the underlying dynamics of both initial and final-state interactions, as well as the information needed to disentangle signal from background contributions.« less
Teachers' Perceptions of Teacher-Child Relationships: Links with Children's Observed Interactions
ERIC Educational Resources Information Center
Hartz, Karyn; Williford, Amanda P.; Koomen, Helma M. Y.
2017-01-01
Research Findings: The present study examined associations between children's classroom interactions and teachers' perceptions of teacher-child relationships during 1 year of preschool. Teachers (n = 223) reported their perceptions of closeness and conflict in their teacher-child relationships in the fall and spring. Children's (n = 895) positive…
Öbrink, Björn; Wasteson, Åke
1971-01-01
The electrostatic interaction of chondroitin sulphate and the chondroitin sulphate–proteoglycan with collagen was studied by chromatography of the glycosaminoglycan and the proteoglycan on a collagen gel. The observed binding between the macromolecules increased with decreasing pH and ionic strength, and was significant under physiological conditions. A study of the interaction between chondroitin sulphate and a preparation of soluble collagen, with a partition-equilibrium technique, afforded similar results. PMID:4256063
Gender discrimination may be worse than you think: testing ordinal interactions in power research.
Elias, Steven M; Cropanzano, Russell
2006-04-01
The authors reanalyze the data of a study by S. M. Elias and R. J. Loomis (2004), which aimed to determine how an instructor's gender may influence his or her ability to gain student compliance. S. M. Elias and R. J. Loomis observed few significant gender effects using traditional multivariate analyses of variance. The authors reanalyze this data using the more appropriate statistical techniques for detecting ordinal interactions recommended by M. J. Strube and P. Bobko (1989) and S. M. Elias (2004). An ordinal interaction occurs when 1 cell of a 2 x 2 design is responsible for a significant interaction (e.g., female instructors suffering only when rated by male students). Reanalysis of the data resulted in more robust findings.
PeV neutrinos from intergalactic interactions of cosmic rays emitted by active galactic nuclei.
Kalashev, Oleg E; Kusenko, Alexander; Essey, Warren
2013-07-26
The observed very high energy spectra of distant blazars are well described by secondary gamma rays produced in line-of-sight interactions of cosmic rays with background photons. In the absence of the cosmic-ray contribution, one would not expect to observe very hard spectra from distant sources, but the cosmic ray interactions generate very high energy gamma rays relatively close to the observer, and they are not attenuated significantly. The same interactions of cosmic rays are expected to produce a flux of neutrinos with energies peaked around 1 PeV. We show that the diffuse isotropic neutrino background from many distant sources can be consistent with the neutrino events recently detected by the IceCube experiment. We also find that the flux from any individual nearby source is insufficient to account for these events. The narrow spectrum around 1 PeV implies that some active galactic nuclei can accelerate protons to EeV energies.
Does Observation of Postural Imbalance Induce a Postural Reaction?
Tia, Banty; Saimpont, Arnaud; Paizis, Christos; Mourey, France; Fadiga, Luciano; Pozzo, Thierry
2011-01-01
Background Several studies bring evidence that action observation elicits contagious responses during social interactions. However automatic imitative tendencies are generally inhibited and it remains unclear in which conditions mere action observation triggers motor behaviours. In this study, we addressed the question of contagious postural responses when observing human imbalance. Methodology/Principal Findings We recorded participants' body sway while they observed a fixation cross (control condition), an upright point-light display of a gymnast balancing on a rope, and the same point-light display presented upside down. Our results showed that, when the upright stimulus was displayed prior to the inverted one, centre of pressure area and antero-posterior path length were significantly greater in the upright condition compared to the control and upside down conditions. Conclusions/Significance These results demonstrate a contagious postural reaction suggesting a partial inefficiency of inhibitory processes. Further, kinematic information was sufficient to trigger this reaction. The difference recorded between the upright and upside down conditions indicates that the contagion effect was dependent on the integration of gravity constraints by body kinematics. Interestingly, the postural response was sensitive to habituation, and seemed to disappear when the observer was previously shown an inverted display. The motor contagion recorded here is consistent with previous work showing vegetative output during observation of an effortful movement and could indicate that lower level control facilitates contagion effects. PMID:21423622
Observing and Understanding Children's Social Interactions. An Impression Management Perspective.
ERIC Educational Resources Information Center
Hatch, J. Amos
1994-01-01
Describes ways of observing and interpreting children's peer social behavior based on the impression management perspective, which focuses on the social construction of a child's individual self-concept. Suggests that teachers and caregivers can use impression management strategies to observe and promote prosocial development in young children.…
Molecular interactions in gelatin/chitosan composite films.
Qiao, Congde; Ma, Xianguang; Zhang, Jianlong; Yao, Jinshui
2017-11-15
Gelatin and chitosan were mixed at different mass ratios in solution forms, and the rheological properties of these film-forming solutions, upon cooling, were studied. The results indicate that the significant interactions between gelatin and chitosan promote the formation of multiple complexes, reflected by an increase in the storage modulus of gelatin solution. Furthermore, these molecular interactions hinder the formation of gelatin networks, consequently decreasing the storage modulus of polymer gels. Both hydrogen bonds and electrostatic interactions are formed between gelatin and chitosan, as evidenced by the shift of the amide-II bands of polymers. X-ray patterns of composite films indicate that the contents of triple helices decrease with increasing chitosan content. Only one glass transition temperature (T g ) was observed in composite films with different composition ratios, and it decreases gradually with an increase in chitosan proportion, indicating that gelatin and chitosan have good miscibility and form a wide range of blends. Copyright © 2017 Elsevier Ltd. All rights reserved.
Tylén, Kristian; Allen, Micah; Hunter, Bjørk K.; Roepstorff, Andreas
2012-01-01
Human cognition has usually been approached on the level of individual minds and brains, but social interaction is a challenging case. Is it best thought of as a self-contained individual cognitive process aiming at an “understanding of the other,” or should it rather be approached as an collective, inter-personal process where individual cognitive components interact on a moment-to-moment basis to form coupled dynamics? In a combined fMRI and eye-tracking study we directly contrasted these models of social cognition. We found that the perception of situations affording social contingent responsiveness (e.g., someone offering or showing you an object) elicited activations in regions of the right posterior temporal sulcus and yielded greater pupil dilation corresponding to a model of coupled dynamics (joint action). In contrast, the social-cognitive perception of someone “privately” manipulating an object elicited activation in medial prefrontal cortex, the right inferior frontal gyrus and right inferior parietal lobus, regions normally associated with Theory of Mind and with the mirror neuron system. Our findings support a distinction in social cognition between social observation and social interaction, and demonstrate that simple ostensive cues may shift participants' experience, behavior, and brain activity between these modes. The identification of a distinct, interactive mode has implications for research on social cognition, both in everyday life and in clinical conditions. PMID:23267322
Tylén, Kristian; Allen, Micah; Hunter, Bjørk K; Roepstorff, Andreas
2012-01-01
Human cognition has usually been approached on the level of individual minds and brains, but social interaction is a challenging case. Is it best thought of as a self-contained individual cognitive process aiming at an "understanding of the other," or should it rather be approached as an collective, inter-personal process where individual cognitive components interact on a moment-to-moment basis to form coupled dynamics? In a combined fMRI and eye-tracking study we directly contrasted these models of social cognition. We found that the perception of situations affording social contingent responsiveness (e.g., someone offering or showing you an object) elicited activations in regions of the right posterior temporal sulcus and yielded greater pupil dilation corresponding to a model of coupled dynamics (joint action). In contrast, the social-cognitive perception of someone "privately" manipulating an object elicited activation in medial prefrontal cortex, the right inferior frontal gyrus and right inferior parietal lobus, regions normally associated with Theory of Mind and with the mirror neuron system. Our findings support a distinction in social cognition between social observation and social interaction, and demonstrate that simple ostensive cues may shift participants' experience, behavior, and brain activity between these modes. The identification of a distinct, interactive mode has implications for research on social cognition, both in everyday life and in clinical conditions.
Potentially harmful drug-drug interactions in the elderly: a review.
Hines, Lisa E; Murphy, John E
2011-12-01
Elderly patients are vulnerable to drug interactions because of age-related physiologic changes, an increased risk for disease associated with aging, and the consequent increase in medication use. The purpose of this narrative review was to describe findings from rigorously designed observational cohort and case-control studies that have assessed specific drug interactions in elderly patients. The PubMed and International Pharmaceutical Abstracts databases were searched for studies published in English over the past 10 years (December 2000-December 2010) using relevant Medical Subject Headings terms (aged; aged, 80 and over; and drug interactions) and search terms (drug interaction and elderly). Search strategies were saved and repeated through September 2011 to ensure that the most recent relevant published articles were identified. Additional articles were found using a search of review articles and reference lists of the identified studies. Studies were included if they were observational cohort or case-control studies that reported specific adverse drug interactions, included patients aged ≥65 years, and evaluated clinically meaningful end points. Studies were excluded if they used less rigorous observational designs, assessed pharmacokinetic/pharmacodynamic properties, evaluated drug-nutrient or drug-disease interactions or interactions of drug combinations used for therapeutic benefit (eg, dual antiplatelet therapy), or had inconclusive evidence. Seventeen studies met the inclusion criteria. Sixteen studies reported an elevated risk for hospitalization in older adults associated with adverse drug interactions. The drug interactions included: angiotensin-converting enzyme (ACE) inhibitors and potassium-sparing diuretics, ACE inhibitors or angiotensin receptor blockers and sulfamethoxazole/trimethoprim, benzodiazepines or zolpidem and interacting medications, calcium channel blockers and macrolide antibiotics, digoxin and macrolide antibiotics, lithium and
Nonstandard neutrino interactions in supernovae
NASA Astrophysics Data System (ADS)
Stapleford, Charles J.; Väänänen, Daavid J.; Kneller, James P.; McLaughlin, Gail C.; Shapiro, Brandon T.
2016-11-01
Nonstandard interactions (NSI) of neutrinos with matter can significantly alter neutrino flavor evolution in supernovae with the potential to impact explosion dynamics, nucleosynthesis, and the neutrinos signal. In this paper, we explore, both numerically and analytically, the landscape of neutrino flavor transformation effects in supernovae due to NSI and find a new, heretofore unseen transformation processes can occur. These new transformations can take place with NSI strengths well below current experimental limits. Within a broad swath of NSI parameter space, we observe symmetric and standard matter-neutrino resonances for supernovae neutrinos, a transformation effect previously only seen in compact object merger scenarios; in another region of the parameter space we find the NSI can induce neutrino collective effects in scenarios where none would appear with only the standard case of neutrino oscillation physics; and in a third region the NSI can lead to the disappearance of the high density Mikheyev-Smirnov-Wolfenstein resonance. Using a variety of analytical tools, we are able to describe quantitatively the numerical results allowing us to partition the NSI parameter according to the transformation processes observed. Our results indicate nonstandard interactions of supernova neutrinos provide a sensitive probe of beyond the Standard Model physics complementary to present and future terrestrial experiments.
How Aboriginal Peer Interactions in Upper Primary School Sport Support Aboriginal Identity
ERIC Educational Resources Information Center
Kickett-Tucker, Cheryl S.
2008-01-01
This ethnographic study tested the hypothesis that positive social interactions in sport will contribute positively to the Aboriginal identity of urban, Australian Aboriginal children. Nine male and female children aged 11-12 years were observed and interviewed. Significant responses were extracted and meanings were identified and grouped into…
Interaction of two laser shocks inside iron samples
NASA Astrophysics Data System (ADS)
de Rességuier, T.; Hallouin, M.
2001-11-01
The interaction of two plane symmetric shocks in a solid sample induces a significant increase of both the pressure and the temperature in the central zone where the incident compressive pulses cross each other. In iron samples, such loading conditions may produce typical structural defects (twins, dislocations) and phase transitions that can be revealed by posttest examination of the recovered targets. We have used two high-power laser beams to irradiate simultaneously both surfaces of thin iron foils. The recovered samples have been sectioned and observed in optical microscopy. A very dense twin distribution in the central zone has confirmed the pressure amplification due to the interaction of the incident shocks. The occurrence of a phase transition has been inferred from the presence of short characteristic twins. Spall fraction has been observed near both irradiated surfaces, and additional damage has been evidenced at the center of the samples. Numerical tools have been adapted to simulate the experiments. Computations have provided estimates of the stress histories inside the samples, and the ability of simple twin, phase change, and spall models has been tested to predict the observed results.
Gaia-GOSA: An interactive service for coordination of asteroid observation campaigns
NASA Astrophysics Data System (ADS)
Santana-Ros, Toni; Bartczak, Przemyslaw; Michalowski, Tadeusz; Marciniak, Anna; Butkiewicz-Bak, Magda; Dudziński, Grzegorz
2016-10-01
We describe the Gaia-Ground-based Observational Service for Asteroids (www.gaiagosa.eu), which is a website aiming to facilitate asteroid observers in contributing to the Gaia mission by gathering lightcurves of selected targets.There are many asteroids which lightcurves cannot be covered during one observing run, like slow rotators,with periods longer than 12 hours. There are also targets with periods commensurate with the Earth's day, sotheir lightcurves cannot be covered by observing from one site only. There are also targets of special interest,like binary objects, where a large amount of data is needed. For all targets like those mentioned above, acoordination of observers is needed, also to avoid unnecessary duplication of data gathering.To that end we have created Gaia-GOSA, a web service which allows coordination between observers, focuseson interesting targets and may avoid observers to unnecessary gather data of the same object at the sametime. Furthermore, it is not necessary to be an advanced observer to contribute to the project. The websiteprepares the observing plan, providing all the necessary information to point your telescope. Thesubscription is free and observers with any level of experience are welcome.All the data gathered by Gaia-GOSA users will be reduced and analyzed by astronomers from the Astronomical Observatory of Adam Mickiewicz University in Poznan (AO AMU). The resulting catalogue, containing all the lightcurves obtained, will be used to enhance the results of the Gaia (cornerstone European Space Agency's mission) inversion algorithm.The project has been developed under funding from the European Space Agency (ESA) and initially was only devoted to help users in planning photometric observations of asteroids. However, in this poster we also present an extended version of the website, which also aims to publish predictions of stellar occultations for selected targets. This work has been done in the framework of the Small Bodies: Near
Spectrophotometric studies on the interaction between (-)-epigallocatechin gallate and lysozyme
NASA Astrophysics Data System (ADS)
Ghosh, Kalyan Sundar; Sahoo, Bijaya Ketan; Dasgupta, Swagata
2008-02-01
Various reported antibacterial activities of (-)-epigallocatechin-3-gallate (EGCG), the major polyphenol of green tea prompted us to study its binding with lysozyme. This has been investigated by fluorescence, circular dichroism (CD) and protein-ligand docking. The binding parameters were determined using a modified Stern-Volmer equation. The thermodynamic parameters are indicative of an initial hydrophobic association. The complex is, however, held together predominantly by van der Waals interactions and hydrogen bonding. CD studies do not indicate any significant changes in the secondary structure of lysozyme. Docking studies revealed that specific interactions are observed with residues Trp 62 and Trp 63.
Intensity and amplitude correlations in the fluorescence from atoms with interacting Rydberg states
NASA Astrophysics Data System (ADS)
Xu, Qing; Mølmer, Klaus
2015-09-01
We explore the fluorescence signals from a pair of atoms driven towards Rydberg states on a three-level ladder transition. The dipole-dipole interactions between Rydberg excited atoms significantly distort the dark state and electromagnetically induced transparency behavior observed with independent atoms and, thus, their steady-state light emission. We calculate and analyze the temporal correlations between intensities and amplitudes of the signals emitted by the atoms and explain their origin in the atomic Rydberg state interactions.
A nested observation and model approach to non linear groundwater surface water interactions.
NASA Astrophysics Data System (ADS)
van der Velde, Y.; Rozemeijer, J. C.; de Rooij, G. H.
2009-04-01
of nested-scale, high frequency observations. The distributed hydrological model results will be used to show transient catchment scale relations between groundwater levels and discharges. These analyses lead to a simple expression that can describe catchment scale groundwater surface water interactions.
Note: Nonpolar solute partial molar volume response to attractive interactions with water.
Williams, Steven M; Ashbaugh, Henry S
2014-01-07
The impact of attractive interactions on the partial molar volumes of methane-like solutes in water is characterized using molecular simulations. Attractions account for a significant 20% volume drop between a repulsive Weeks-Chandler-Andersen and full Lennard-Jones description of methane interactions. The response of the volume to interaction perturbations is characterized by linear fits to our simulations and a rigorous statistical thermodynamic expression for the derivative of the volume to increasing attractions. While a weak non-linear response is observed, an average effective slope accurately captures the volume decrease. This response, however, is anticipated to become more non-linear with increasing solute size.
Note: Nonpolar solute partial molar volume response to attractive interactions with water
DOE Office of Scientific and Technical Information (OSTI.GOV)
Williams, Steven M.; Ashbaugh, Henry S., E-mail: hanka@tulane.edu
2014-01-07
The impact of attractive interactions on the partial molar volumes of methane-like solutes in water is characterized using molecular simulations. Attractions account for a significant 20% volume drop between a repulsive Weeks-Chandler-Andersen and full Lennard-Jones description of methane interactions. The response of the volume to interaction perturbations is characterized by linear fits to our simulations and a rigorous statistical thermodynamic expression for the derivative of the volume to increasing attractions. While a weak non-linear response is observed, an average effective slope accurately captures the volume decrease. This response, however, is anticipated to become more non-linear with increasing solute size.
NASA Astrophysics Data System (ADS)
Hristova-Veleva, S. M.; Chen, H.; Gopalakrishnan, S.; Haddad, Z. S.
2017-12-01
Tropical cyclones (TCs) are the product of complex multi-scale processes and interactions. The role of the environment has long been recognized. However, recent research has shown that convective-scale processes in the hurricane core might also play a crucial role in determining TCs intensity and size. Several studies have linked Rapid Intensification to the characteristics of the convective clouds (shallow versus deep), their organization (isolated versus wide-spread) and their location with respect to dynamical controls (the vertical shear, the radius of maximum wind). Yet a third set of controls signifies the interaction between the storm-scale and large-scale processes. Our goal is to use observations and models to advance the still-lacking understanding of these processes. Recently, hurricane models have improved significantly. However, deterministic forecasts have limitations due to the uncertainty in the representation of the physical processes and initial conditions. A crucial step forward is the use of high-resolution ensembles. We adopt the following approach: i) generate a high resolution ensemble forecast using HWRF; ii) produce synthetic data (e.g. brightness temperature) from the model fields for direct comparison to satellite observations; iii) develop metrics to allow us to sub-select the realistic members of the ensemble, based on objective measures of the similarity between observed and forecasted structures; iv) for these most-realistic members, determine the skill in forecasting TCs to provide"guidance on guidance"; v) use the members with the best predictive skill to untangle the complex multi-scale interactions. We will report on the first three goals of our research, using forecasts and observations of hurricane Edouard (2014), focusing on RI. We will focus on describing the metrics for the selection of the most appropriate ensemble members, based on applying low-wave number analysis (WNA - Hristova-Veleva et al., 2016) to the observed and
Zinc-arsenic interactions in soil: Solubility, toxicity and uptake.
Kader, Mohammed; Lamb, Dane T; Wang, Liang; Megharaj, Mallavarapu; Naidu, Ravi
2017-11-01
Arsenic (As) and zinc (Zn) are common co-contaminants in mining impacted soils. Their interaction on solubility and toxicity when present concurrently is not well understood in natural systems. The aim of this study was to observe their interaction in solubility (soil-solution), bioaccumulation (shoot uptake) and toxicity to cucumber (Cucumis sativa L) conducting 4 weeks pot study in 5 different soils spiked with As (0, 2, 4, 8 to 1024 mg kg -1 ) individually and with Zn at two phytotoxic doses. The As pore-water concentration was significantly reduced (df = 289, Adjusted R 2 = 0.84, p < 0.01) in the presence of Zn in the whole dataset, whereas Zn and Zn 2+ activity in pore-water was reduced significantly only in the two alkaline soils. This outcome may be due to adsorption/surface precipitation or tertiary bridging complexation. No homogenous precipitation of zinc arsenate could be established using electron microscopy, XRD or even equilibrium calculations. For bioaccumulation phase, no significant effect of Zn on As uptake was observed except acidic MG soil whereas, Zn uptake was significantly reduced (p < 0.05) by As in whole dataset. However, an additive response was observed mostly except acidic MG soil. The synergistic response (more than additive) was predominant in this soil for a wide range of inhibition concentration (0-80%) at both Zn EC10 and EC50 levels. Since additive response is mostly considered in risk assessment for mixtures, precautions should be implemented for assessment of toxicity for As-Zn mixture in acidic soil due to their synergistic response in some soils. Copyright © 2017 Elsevier Ltd. All rights reserved.
Anåker, Anna; von Koch, Lena; Sjöstrand, Christina; Bernhardt, Julie; Elf, Marie
2017-01-01
Early mobilization and rehabilitation, multidisciplinary stroke expertise and comprehensive therapies are fundamental in a stroke unit. To achieve effective and safe stroke care, the physical environment in modern stroke units should facilitate the delivery of evidence-based care. Therefore, the purpose of this study was to explore patients' activities and interactions in a stroke unit before the reconstruction of the physical environment, while in a temporary location and after reconstruction. This case study examined a stroke unit as an integrated whole. The data were collected using a behavioral mapping technique at three different time points: in the original unit, in the temporary unit and in the new unit. A total of 59 patients were included. The analysis included field notes from observations of the physical environment and examples from planning and design documents. The findings indicated that in the new unit, the patients spent more time in their rooms, were less active, and had fewer interactions with staff and family than the patients in the original unit. The reconstruction involved a change from a primarily multi-bed room design to single-room accommodations. In the new unit, the patients' lounge was located in a far corner of the unit with a smaller entrance than the patients' lounge in the old unit, which was located at the end of a corridor with a noticeable entrance. Changes in the design of the stroke unit may have influenced the patients' activities and interactions. This study raises the question of how the physical environment should be designed in the future to facilitate the delivery of health care and improve outcomes for stroke patients. This research is based on a case study, and although the results should be interpreted with caution, we strongly recommend that environmental considerations be included in future stroke guidelines.
Oxidative balance and colon and rectal cancer: interaction of lifestyle factors and genes.
Slattery, Martha L; Lundgreen, Abbie; Welbourn, Bill; Wolff, Roger K; Corcoran, Christopher
2012-06-01
Pro-oxidant and anti-oxidant genetic and lifestyle factors can contribute to an individual's level of oxidative stress. We hypothesize that diet, lifestyle and genetic factors work together to influence colon and rectal cancer through an oxidative balance mechanism. We evaluated nine markers for eosinophil peroxidase (EPX), two for myeloperoxidase (MPO), four for hypoxia-inducible factor-1A (HIFIA), and 16 for inducible nitric oxide synthase (NOS2A) in conjunction with dietary antioxidants, aspirin/NSAID use, and cigarette smoking. We used data from population-based case-control studies (colon cancer n=1555 cases, 1956 controls; rectal cancer n=754 cases, 959 controls). Only NOS2A rs2297518 was associated with colon cancer (OR 0.86 95% CI 0.74, 0.99) and EPX rs2302313 and MPO rs2243828 were associated with rectal cancer (OR 0.75 95% CI 0.59, 0.96; OR 0.81 95% CI 0.67, 0.99 respectively) for main effects. However, after adjustment for multiple comparisons we observed the following significant interactions for colon cancer: NOS2A and lutein, EPX and aspirin/NSAID use, and NOS2A (4 SNPs) and cigarette smoking. For rectal cancer we observed the following interactions after adjustment for multiple comparisons: HIF1A and vitamin E, NOS2A (3SNPs) with calcium; MPO with lutein; HIF1A with lycopene; NOS2A with selenium; EPX and NOS2A with aspirin/NSAID use; HIF1A, MPO, and NOS2A (3 SNPs) with cigarette smoking. We observed significant interaction between a composite oxidative balance score and a polygenic model for both colon (p interaction 0.0008) and rectal cancer (p=0.0018). These results suggest the need to comprehensively evaluate interactions to assess the contribution of risk from both environmental and genetic factors. Copyright © 2012 Elsevier B.V. All rights reserved.
Lessons from life: Learning from exhibits, animals and interaction in a museum
NASA Astrophysics Data System (ADS)
Goldowsky, Alexander Noah
This study examines the effect of interaction on visitor behavior at a public aquarium, experimentally comparing one exhibit under interactive and noninteractive conditions. A quantitative analysis showed that the time visitor groups spent in the study area significantly increased in the interactive condition (median 73 vs. 32 seconds). Further, this effect extended only to those groups within the interactive condition in which at least one member operated the exhibit (median 102 vs. 36 seconds). Both median times and survival curves are compared, and the analysis controlled for group size, age and sex ratios, visitor density, queuing time, and animal activity. Qualitative analyses focused on visitors' spontaneous conversation at the exhibit. Interactive visitors were found to engage in more in-depth exploration, including conducting informal experiments. The amount of discussion was found to correlate with stay time (r = 0.47). Visitor discussion centered on the exhibit, with frequent observations of penguin behavior. Greater enthusiasm was observed for interactive visitors, and coding showed interactive visitors laughed more frequently, and were significantly more likely to speculate on the penguins' reactions and motivations for behaviors. The experimental setup included a control condition consisting of a typical aquarium exhibit, including live penguins, naturalistic habitat, and graphics. The interactive condition added a device designed to mediate a two-way interaction between the visitors and penguins: visitors moved a light beam across the bottom of the pool. The penguins, intern, chased the light. This exhibit was designed both to benefit visitors and to serve as behavioral enrichment for the penguins. A third condition employed an automatically moving light, which elicited similar penguin behaviors, but without allowing visitor interaction. Videotaped data was analyzed for 301 visitor groups (756 individuals). A supplemental study employed video recall
Kanapathipillai, Rupa; McManus, Hamish; Kamarulzaman, Adeeba; Lim, Poh Lian; Templeton, David J; Law, Matthew; Woolley, Ian
2014-01-01
Magnitude and frequency of HIV viral load blips in resource-limited settings, has not previously been assessed. This study was undertaken in a cohort from a high income country (Australia) known as AHOD (Australian HIV Observational Database) and another cohort from a mixture of Asian countries of varying national income per capita, TAHOD (TREAT Asia HIV Observational Database). Blips were defined as detectable VL (≥ 50 copies/mL) preceded and followed by undetectable VL (<50 copies/mL). Virological failure (VF) was defined as two consecutive VL ≥50 copies/ml. Cox proportional hazard models of time to first VF after entry, were developed. 5040 patients (AHOD n = 2597 and TAHOD n = 2521) were included; 910 (18%) of patients experienced blips. 744 (21%) and 166 (11%) of high- and middle/low-income participants, respectively, experienced blips ever. 711 (14%) experienced blips prior to virological failure. 559 (16%) and 152 (10%) of high- and middle/low-income participants, respectively, experienced blips prior to virological failure. VL testing occurred at a median frequency of 175 and 91 days in middle/low- and high-income sites, respectively. Longer time to VF occurred in middle/low income sites, compared with high-income sites (adjusted hazards ratio (AHR) 0.41; p<0.001), adjusted for year of first cART, Hepatitis C co-infection, cART regimen, and prior blips. Prior blips were not a significant predictor of VF in univariate analysis (AHR 0.97, p = 0.82). Differing magnitudes of blips were not significant in univariate analyses as predictors of virological failure (p = 0.360 for blip 50-≤1000, p = 0.309 for blip 50-≤400 and p = 0.300 for blip 50-≤200). 209 of 866 (24%) patients were switched to an alternate regimen in the setting of a blip. Despite a lower proportion of blips occurring in low/middle-income settings, no significant difference was found between settings. Nonetheless, a substantial number of participants were switched
Learning to Observe "and" Infer
ERIC Educational Resources Information Center
Hanuscin, Deborah L.; Park Rogers, Meredith A.
2008-01-01
Researchers describe the need for students to have multiple opportunities and social interaction to learn about the differences between observation and inference and their role in developing scientific explanations (Harlen 2001; Simpson 2000). Helping children develop their skills of observation and inference in science while emphasizing the…
Choi, Myung-Jin; Yohannes, Sileshi Belew; Lee, Seung-Jin; Damte, Dereje; Kim, Jong-Choon; Suh, Joo-Won; Park, Seung-Chun
2014-03-01
The pharmacokinetic interaction of enrofloxacin and trimethoprim was evaluated after single-dose intraperitoneal or oral co-administration in rats. Plasma concentrations of the two drugs were determined by high-performance liquid chromatography. Following intraperitoneal combination, a significant (P < 0.05) increase in mean values of plasma half-life (t 1/2) and maximum plasma concentration (C max) was observed for enrofloxacin and trimethoprim, respectively. There was a significant (P < 0.05) increase in mean values of area under the plasma drug concentration versus time from time zero to infinity (AUC0-∞) and C max between combined oral doses (10, 30 and 100 mg/kg) of both antibacterial drugs. Also, after oral conjugation a significant difference in mean values of MRT0-∞ was observed between lower (10 mg/kg) and higher (100 mg/kg) doses of both drugs. A significant increase in pharmacokinetic parameters of both drugs in combined intraperitoneal and oral doses indicated pharmacokinetic interaction of enrofloxacin and trimethoprim. Further study is recommended in other species of animals.
Shlomai, Joseph
2010-11-01
Protein-DNA interactions play a key role in the regulation of major cellular metabolic pathways, including gene expression, genome replication, and genomic stability. They are mediated through the interactions of regulatory proteins with their specific DNA-binding sites at promoters, enhancers, and replication origins in the genome. Redox signaling regulates these protein-DNA interactions using reactive oxygen species and reactive nitrogen species that interact with cysteine residues at target proteins and their regulators. This review describes the redox-mediated regulation of several master regulators of gene expression that control the induction and suppression of hundreds of genes in the genome, regulating multiple metabolic pathways, which are involved in cell growth, development, differentiation, and survival, as well as in the function of the immune system and cellular response to intracellular and extracellular stimuli. It also discusses the role of redox signaling in protein-DNA interactions that regulate DNA replication. Specificity of redox regulation is discussed, as well as the mechanisms providing several levels of redox-mediated regulation, from direct control of DNA-binding domains through the indirect control, mediated by release of negative regulators, regulation of redox-sensitive protein kinases, intracellular trafficking, and chromatin remodeling.
Plasma wave observations at comet giacobini-zinner.
Scarf, F L; Coroniti, F V; Kennel, C F; Gurnett, D A; Ip, W H; Smith, E J
1986-04-18
The plasma wave instrument on the International Cometary Explorer (ICE) detected bursts of strong ion acoustic waves almost continuously when the spacecraft was within 2 million kilometers of the nucleus of comet Giacobini-Zinner. Electromagnetic whistlers and low-level electron plasma oscillations were also observed in this vast region that appears to be associated with heavy ion pickup. As ICE came closer to the anticipated location of the bow shock, the electromagnetic and electrostatic wave levels increased significantly, but even in the midst of this turbulence the wave instrument detected structures with familiar bow shock characteristics that were well correlated with observations of localized electron heating phenomena. Just beyond the visible coma, broadband waves with amplitudes as high as any ever detected by the ICE plasma wave instrument were recorded. These waves may account for the significant electron heating observed in this region by the ICE plasma probe, and these observations of strong wave-particle interactions may provide answers to longstanding questions concerning ionization processes in the vicinity of the coma. Near closest approach, the plasma wave instrument detected broadband electrostatic noise and a changing pattern of weak electron plasma oscillations that yielded a density profile for the outer layers of the cold plasma tail. Near the tail axis the plasma wave instrument also detected a nonuniform flux of dust impacts, and a preliminary profile of the Giacobini-Zinner dust distribution for micrometer-sized particles is presented.
Interharmonic modulation products as a means to quantify nonlinear D-region interactions
NASA Astrophysics Data System (ADS)
Moore, Robert
Experimental observations performed during dual beam ionospheric HF heating experiments at the High frequency Active Auroral Research Program (HAARP) HF transmitter in Gakona, Alaska are used to quantify the relative importance of specific nonlinear interactions that occur within the D region ionosphere. During these experiments, HAARP broadcast two amplitude modulated HF beams whose center frequencies were separated by less than 20 kHz. One beam was sinusoidally modulated at 500 Hz while the second beam was sinusoidally modulated using a 1-7 kHz linear frequency-time chirp. ELF/VLF observations performed at two different locations (3 and 98 km from HAARP) provide clear evidence of strong interactions between all field components of the two HF beams in the form of low and high order interharmonic modulation products. From a theoretical standpoint, the observed interharmonic modulation products could be produced by several different nonlinearities. The two primary nonlinearities take the form of wave-medium interactions (i.e., cross modulation), wherein the ionospheric conductivity modulation produced by one signal crosses onto the other signal via collision frequency modification, and wave-wave interactions, wherein the conduction current associated with one wave mixes with the electric field of the other wave to produce electron temperature oscillations. We are able to separate and quantify these two different nonlinearities, and we conclude that the wave-wave interactions dominate the wave-medium interactions by a factor of two. These results are of great importance for the modeling of transioinospheric radio wave propagation, in that both the wave-wave and the wave-medium interactions could be responsible for a significant amount of anomalous absorption.
Lipid interactions in breadmaking.
Carr, N O; Daniels, N W; Frazier, P J
1992-01-01
Both the natural lipids of flour and added fats are known to play an important role during the production of bread. In this review, the chemical and physical interactions of fat have been assessed in an attempt to explain these technological functions. Particular emphasis has been placed on the "binding" or complexing of lipid by flour proteins during the development of dough. While publications in this field have frequently been contradictory, evidence now indicates that observed lipid binding may involve lipid mesophase transformation and the nonspecific occlusion of lipid phases within the gluten network. The significance of these suggested events has been compared with current theories of lipid function in the breadmaking process.
2012-01-01
Background Interaction programs involving dolphins and patients with various pathologies or developmental disorders (e.g., cerebral palsy, intellectual impairment, autism, atopic dermatitis, post-traumatic stress disorder, depression) have stimulated interest in their beneficial effects and therapeutic potential. However, the true effects observed in different clinical and psycho-educational setups are still controversial. Results An evaluation protocol consisting of the Childhood Autism Rating Scale (CARS), Psychoeducational Profile-Revised (PEP-R), Autism Treatment Evaluation Checklist (ATEC), Theory of Mind Tasks (ToM Tasks) and a custom-made Interaction Evaluation Grid (IEG) to evaluate behavioural complexity during in-pool interactions was applied to 10 children diagnosed with Autism Spectrum Disorders. The ATEC, ToM Tasks and CARS results show no benefits of the dolphin interaction program. Interestingly, the PEP-R suggests some statistically significant effects on ‘Overall development score’, as well as on their ‘Fine motor development’, ‘Cognitive performance’ and ‘Cognitive verbal development’. Also, a significant evolution in behavioural complexity was shown by the IEG. Conclusions This study does not support significant developmental progress resulting from the dolphin interaction program. PMID:22537536
Observations of iodine monoxide in the Arctic troposphere
NASA Astrophysics Data System (ADS)
Zielcke, Johannes; Lampel, Johannes; Frieß, Udo; Sihler, Holger; Netcheva, Stoyka; Platt, Ulrich
2014-05-01
A unique feature of the polar troposphere is the strong impact of halogen photochemistry, in which reactive halogen species are responsible for ozone depletion as well as the oxidation of elemental mercury and dimethyl sulfide. The sources, however, as well as release and recycling mechanisms of these halogen species are far from being completely understood, especially the role of chlorine and iodine compounds. For iodine, which is thought to be produced either by organic precursors or inorganic processes, one curious issue is the difference of its role in the two polar regions, the Arctic and the Antarctic. Satellite observations show significant quantities of IO in large areas of Antarctica and the surrounding ocean and comparatively no IO in the Arctic. This is in concordance with some ground-based remote sensing observations in Antarctica, whereas publications of IO mixing ratios or upper limits from the Arctic are seldom. This strong hemispheric dichotomy may however not be the whole picture. Here we present data from ground-based MAX-DOAS observations in the Arctic. Long-term measurements from Alert, Canada (82N) spanning the period from 2007 until 2013 indicate elevated and significant quantities of IO in the troposphere in late spring and early summer comparable to ground-based observations in Antarctica. This is backed up by ship-borne MAX-DOAS measurements in Baffin Bay during summer 2010, which also show elevated and significant amounts of IO. Furthermore the interaction of IO and BrO will be shown, as well as the influence of meteorological parameters and the data will be compared to other measurements.
Product interactions and feedback in diffusion-controlled reactions
NASA Astrophysics Data System (ADS)
Roa, Rafael; Siegl, Toni; Kim, Won Kyu; Dzubiella, Joachim
2018-02-01
Steric or attractive interactions among reactants or between reactants and inert crowders can substantially influence the total rate of a diffusion-influenced reaction in the liquid phase. However, the role of the product species, which has typically different physical properties than the reactant species, has been disregarded so far. Here we study the effects of reactant-product and product-product interactions as well as asymmetric diffusion properties on the rate of diffusion-controlled reactions in the classical Smoluchowski-setup for chemical transformations at a perfect catalytic sphere. For this, we solve the diffusion equation with appropriate boundary conditions coupled by a mean-field approach on the second virial level to account for the particle interactions. We find that all particle spatial distributions and the total rate can change significantly, depending on the diffusion and interaction properties of the accumulated products. Complex competing and self-regulating (homeostatic) or self-amplifying effects are observed for the system, leading to both decrease and increase in the rates, as the presence of interacting products feeds back to the reactant flux and thus the rate with which the products are generated.
Dynamics of Entangled Polymers: Role of Attractive Interactions
NASA Astrophysics Data System (ADS)
Grest, Gary S.; Koski, Jason
The coupled dynamics of entangled polymers, which span broad time and length scales, govern their unique viscoelastic properties. Numerical simulations of highly coarse grained models are often used to follow chain mobility from the intermediate Rouse and reptation regimes to the late time diffusive regime. In these models, purely repulsive interactions between monomers are typically used because it is less computationally expensive than including attractive interactions. The effect of including the attractive interaction on the local and macroscopic properties of entangled polymer melts is explored over a wide temperature range using large scale molecular dynamics simulations. Attractive interactions are shown to have little effect on the local packing for all temperatures T and chain mobility for T higher than about twice the glass transition Tg. For lower T, the attractive interactions play a significant role, reducing the chain mobility compared to the repulsive case. As T approaches Tg breakdown of time-temperature superposition for the stress autocorrelation function is observed. Sandia National Labs is a multiprogram laboratory managed and operated by Sandia Corporation, a Lockheed-Martin Company, for the U.S. Dept of Energy under Contract No. DEAC04-94AL85000.
Zeng, Yi; Chen, Huashuai; Ni, Ting; Ruan, Rongping; Feng, Lei; Nie, Chao; Cheng, Lingguo; Li, Yang; Tao, Wei; Gu, Jun; Land, Kenneth C; Yashin, Anatoli; Tan, Qihua; Yang, Ze; Bolund, Lars; Yang, Huanming; Hauser, Elizabeth; Willcox, D Craig; Willcox, Bradley J; Tian, Xiao-Li; Vaupel, James W
2015-04-01
Logistic regression analysis based on data from 822 Han Chinese oldest old aged 92+ demonstrated that interactions between carrying FOXO1A-266 or FOXO3-310 or FOXO3-292 and tea drinking at around age 60 or at present time were significantly associated with lower risk of cognitive disability at advanced ages. Associations between tea drinking and reduced cognitive disability were much stronger among carriers of the genotypes of FOXO1A-266 or FOXO3-310 or FOXO3-292 compared with noncarriers, and it was reconfirmed by analysis of three-way interactions across FOXO genotypes, tea drinking at around age 60, and at present time. Based on prior findings from animal and human cell models, we postulate that intake of tea compounds may activate FOXO gene expression, which in turn may positively affect cognitive function in the oldest old population. Our empirical findings imply that the health benefits of particular nutritional interventions, including tea drinking, may, in part, depend upon individual genetic profiles. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Mitigation of wind tunnel wall interactions in subsonic cavity flows
DOE Office of Scientific and Technical Information (OSTI.GOV)
Wagner, Justin L.; Casper, Katya Marie; Beresh, Steven J.
In this study, the flow over an open aircraft bay is often represented in a wind tunnel with a cavity. In flight, this flow is unconfined, though in experiments, the cavity is surrounded by wind tunnel walls. If untreated, wind tunnel wall effects can lead to significant distortions of cavity acoustics in subsonic flows. To understand and mitigate these cavity–tunnel interactions, a parametric approach was taken for flow over an L/D = 7 cavity at Mach numbers 0.6–0.8. With solid tunnel walls, a dominant cavity tone was observed, likely due to an interaction with a tunnel duct mode. Furthermore, anmore » acoustic liner opposite the cavity decreased the amplitude of the dominant mode and its harmonics, a result observed by previous researchers. Acoustic dampeners were also placed in the tunnel sidewalls, which further decreased the dominant mode amplitudes and peak amplitudes associated with nonlinear interactions between cavity modes. This then indicates that cavity resonance can be altered by tunnel sidewalls and that spanwise coupling should be addressed when conducting subsonic cavity experiments. Though mechanisms for dominant modes and nonlinear interactions likely exist in unconfined cavity flows, these effects can be amplified by the wind tunnel walls.« less
Mitigation of wind tunnel wall interactions in subsonic cavity flows
Wagner, Justin L.; Casper, Katya Marie; Beresh, Steven J.; ...
2015-03-06
In this study, the flow over an open aircraft bay is often represented in a wind tunnel with a cavity. In flight, this flow is unconfined, though in experiments, the cavity is surrounded by wind tunnel walls. If untreated, wind tunnel wall effects can lead to significant distortions of cavity acoustics in subsonic flows. To understand and mitigate these cavity–tunnel interactions, a parametric approach was taken for flow over an L/D = 7 cavity at Mach numbers 0.6–0.8. With solid tunnel walls, a dominant cavity tone was observed, likely due to an interaction with a tunnel duct mode. Furthermore, anmore » acoustic liner opposite the cavity decreased the amplitude of the dominant mode and its harmonics, a result observed by previous researchers. Acoustic dampeners were also placed in the tunnel sidewalls, which further decreased the dominant mode amplitudes and peak amplitudes associated with nonlinear interactions between cavity modes. This then indicates that cavity resonance can be altered by tunnel sidewalls and that spanwise coupling should be addressed when conducting subsonic cavity experiments. Though mechanisms for dominant modes and nonlinear interactions likely exist in unconfined cavity flows, these effects can be amplified by the wind tunnel walls.« less
NASA Technical Reports Server (NTRS)
McElroy, Mark; Jackson, Wade; Pankow, Mark
2016-01-01
It is not easy to isolate the damage mechanisms associated with low-velocity impact in composites using traditional experiments. In this work, a new experiment is presented with the goal of generating data representative of progressive damage processes caused by low-velocity impact in composite materials. Carbon fiber reinforced polymer test specimens were indented quasi-statically such that a biaxial-bending state of deformation was achieved. As a result, a three-dimensional damage process, involving delamination and delamination-migration, was observed and documented using ultrasonic and x-ray computed tomography. Results from two different layups are presented in this paper. Delaminations occurred at up to three different interfaces and interacted with one another via transverse matrix cracks. Although this damage pattern is much less complex than that of low-velocity impact on a plate, it is more complex than that of a standard delamination coupon test and provides a way to generate delamination, matrix cracking, and delamination-migration in a controlled manner. By limiting the damage process in the experiment to three delaminations, the same damage mechanisms seen during impact could be observed but in a simplified manner. This type of data is useful in stages of model development and validation when the model is capable of simulating simple tests, but not yet capable of simulating more complex and realistic damage scenarios.
Assessment of Gene-by-Sex Interaction Effect on Bone Mineral Density
Liu, Ching-Ti; Estrada, Karol; Yerges-Armstrong, Laura M.; Amin, Najaf; Evangelou, Evangelos; Li, Guo; Minster, Ryan L.; Carless, Melanie A.; Kammerer, Candace M.; Oei, Ling; Zhou, Yanhua; Alonso, Nerea; Dailiana, Zoe; Eriksson, Joel; García-Giralt, Natalia; Giroux, Sylvie; Husted, Lise Bjerre; Khusainova, Rita I.; Koromila, Theodora; Kung, Annie WaiChee; Lewis, Joshua R.; Masi, Laura; Mencej-Bedrac, Simona; Nogues, Xavier; Patel, Millan S.; Prezelj, Janez; Richards, J Brent; Sham, Pak Chung; Spector, Timothy; Vandenput, Liesbeth; Xiao, Su-Mei; Zheng, Hou-Feng; Zhu, Kun; Balcells, Susana; Brandi, Maria Luisa; Frost, Morten; Goltzman, David; González-Macías, Jesús; Karlsson, Magnus; Khusnutdinova, Elza K.; Kollia, Panagoula; Langdahl, Bente Lomholt; Ljunggren, Östen; Lorentzon, Mattias; Marc, Janja; Mellström, Dan; Ohlsson, Claes; Olmos, José M.; Ralston, Stuart H.; Riancho, José A.; Rousseau, François; Urreizti, Roser; Van Hul, Wim; Zarrabeitia, María T.; Castano-Betancourt, Martha; Demissie, Serkalem; Grundberg, Elin; Herrera, Lizbeth; Kwan, Tony; Medina-Gómez, Carolina; Pastinen, Tomi; Sigurdsson, Gunnar; Thorleifsson, Gudmar; vanMeurs, Joyce B.J.; Blangero, John; Hofman, Albert; Liu, Yongmei; Mitchell, Braxton D.; O’Connell, Jeffrey R.; Oostra, Ben A.; Rotter, Jerome I; Stefansson, Kari; Streeten, Elizabeth A.; Styrkarsdottir, Unnur; Thorsteinsdottir, Unnur; Tylavsky, Frances A.; Uitterlinden, Andre; Cauley, Jane A.; Harris, Tamara B.; Ioannidis, John P.A.; Psaty, Bruce M.; Robbins, John A; Zillikens, M. Carola; vanDuijn, Cornelia M.; Prince, Richard L.; Karasik, David; Rivadeneira, Fernando; Kiel, Douglas P.; Cupples, L. Adrienne; Hsu, Yi-Hsiang
2012-01-01
Background Sexual dimorphism in various bone phenotypes, including bone mineral density (BMD), is widely observed; however the extent to which genes explain these sex differences is unclear. To identify variants with different effects by sex, we examined gene-by-sex autosomal interactions genome-wide, and performed eQTL analysis and bioinformatics network analysis. Methods We conducted an autosomal genome-wide meta-analysis of gene-by-sex interaction on lumbar spine (LS-) and femoral neck (FN-) BMD, in 25,353 individuals from eight cohorts. In a second stage, we followed up the 12 top SNPs (P<1×10−5) in an additional set of 24,763 individuals. Gene-by-sex interaction and sex-specific effects were examined in these 12 SNPs. Results We detected one novel genome-wide significant interaction associated with LS-BMD at the Chr3p26.1-p25.1 locus, near the GRM7 gene (male effect = 0.02 & p-value = 3.0×10−5; female effect = −0.007 & p-value=3.3×10−2) and eleven suggestive loci associated with either FN- or LS-BMD in discovery cohorts. However, there was no evidence for genome-wide significant (P<5×10−8) gene-by-sex interaction in the joint analysis of discovery and replication cohorts. Conclusion Despite the large collaborative effort, no genome-wide significant evidence for gene-by-sex interaction was found influencing BMD variation in this screen of autosomal markers. If they exist, gene-by-sex interactions for BMD probably have weak effects, accounting for less than 0.08% of the variation in these traits per implicated SNP. PMID:22692763
NASA Astrophysics Data System (ADS)
Mavromatos, Nick E.; Argüelles, Carlos R.; Ruffini, Remo; Rueda, Jorge A.
Self-interacting dark matter (SIDM) is a hypothetical form of dark matter (DM), characterized by relatively strong (compared to the weak interaction strength) self-interactions (SIs), which has been proposed to resolve a number of issues concerning tensions between simulations and observations at the galactic or smaller scales. We review here some recent developments discussed at the 14th Marcel Grossmann Meeting (MG14), paying particular attention to restrictions on the SIDM (total) cross-section from using novel observables in merging galactic structures, as well as the rôle of SIDM on the Milky Way halo and its central region. We report on some interesting particle-physics inspired SIDM models that were discussed at MG14, namely the glueball DM, and a right-handed neutrino DM (with mass of a few tens of keV, that may exist in minimal extensions of the standard model (SM)), interacting among themselves via vector bosons mediators in the dark sector. A detailed phenomenology of the latter model on galactic scales, as well as the potential role of the right handed neutrinos in alleviating some of the small-scale cosmology problems, namely the discrepancies between observations and numerical simulations within standard ΛCDM and ΛWDM cosmologies are reported.
NASA Astrophysics Data System (ADS)
Pluecker, T.; Wegewijs, M. R.; Splettstoesser, J.
2017-04-01
We set up a general density-operator approach to geometric steady-state pumping through slowly driven open quantum systems. This approach applies to strongly interacting systems that are weakly coupled to multiple reservoirs at high temperature, illustrated by an Anderson quantum dot. Pumping gives rise to a nonadiabatic geometric phase that can be described by a framework originally developed for classical dissipative systems by Landsberg. This geometric phase is accumulated by the transported observable (charge, spin, energy) and not by the quantum state. It thus differs radically from the adiabatic Berry-Simon phase, even when generalizing it to mixed states, following Sarandy and Lidar. As a key feature, our geometric formulation of pumping stays close to a direct physical intuition (i) by tying gauge transformations to calibration of the meter registering the transported observable and (ii) by deriving a geometric connection from a driving-frequency expansion of the current. Furthermore, our approach provides a systematic and efficient way to compute the geometric pumping of various observables, including charge, spin, energy, and heat. These insights seem to be generalizable beyond the present paper's working assumptions (e.g., Born-Markov limit) to more general open-system evolutions involving memory and strong-coupling effects due to low-temperature reservoirs as well. Our geometric curvature formula reveals a general experimental scheme for performing geometric transport spectroscopy that enhances standard nonlinear spectroscopies based on measurements for static parameters. We indicate measurement strategies for separating the useful geometric pumping contribution to transport from nongeometric effects. A large part of the paper is devoted to an explicit comparison with the Sinitsyn-Nemenmann full-counting-statistics (FCS) approach to geometric pumping, restricting attention to the first moments of the pumped observable. Covering all key aspects, gauge
NASA Astrophysics Data System (ADS)
Anderson, D. C.; Dickerson, R. R.; Loughner, C.
2013-12-01
NOx and CO not only adversely impact human health, but they, along with associated VOCs, are also important precursors for O3 formation. While ambient NOx and CO concentrations have decreased dramatically over the past 10-20 years, O3 has remained a more recalcitrant problem, particularly in the Baltimore/Washington region. Reduction of O3 production requires that emissions inventories, such as the National Emissions Inventory (NEI), accurately capture total emissions of CO and NOx while also correctly apportioning them among different sectors. Previous evaluations of the NEI paint different pictures of its accuracy, with assertions that it overestimates either one or both of CO and NOx from anywhere between 25 percent to a factor of 2. These conflicting claims warrant further investigation. In this study, measurements of NOx and CO taken aboard the NOAA P3B airplane during the 2011 DISCOVER-AQ field campaign were used to determine the NOx/CO emissions ratio at 6 locations in the Washington/Baltimore region. An average molar emissions ratio of 12.8 × 1.2 CO/NOx was found by calculating the change in CO over the change in NOx from vertical concentration profiles in the planetary boundary layer. Ratios showed little variation with location. Observed values were approximately a factor of 1.35 - 1.75 times greater than that predicted by the annual, countywide emissions ratio from the 2008 NEI. When compared to a temporalized, gridded version of the inventory processed by SMOKE, ratio observations were greater than that predicted by inventories by up to a factor of 2. Comparison of the in situ measurements and remotely sensed observations from MOPITT of CO to the Community Multiscale Air Quality (CMAQ) model agree within 10-35 percent, with the model higher on average. Measurements of NOy by two separate analytical techniques, on the other hand, show that CMAQ consistently and significantly overestimates NOy concentrations. Combined with the CO observations, this
Clinical significance of TC21 overexpression in oral cancer.
Macha, Muzafar A; Matta, Ajay; Sriram, Uma; Thakkar, Alok; Shukla, N K; Datta Gupta, Siddhartha; Ralhan, Ranju
2010-07-01
In search of novel molecular markers for oral cancer, we reported increased levels of TC21/R-Ras2 transcripts in oral squamous cell carcinoma by differential display. The aim of this study was to determine the clinical significance of TC21 in oral cancer. Immunohistochemical analysis of TC21 protein expression was carried out in 120 leukoplakias, 83 OSCCs and 30 non-malignant tissues, confirmed by immunoblotting, and correlated with clinicopathological parameters as well as disease prognosis. Co-immunoprecipitation assays were carried out to identify the interaction partners of TC21 protein in oral cancer cells and tissues. TC21 nuclear expression increased from normal oral tissues to leukoplakia and frank malignancy (P < 0.001). TC21 overexpression was observed in 74.2% leukoplakia with no dysplasia, 75.9% dysplasias and 79.5% OSCCs in comparison with normal oral tissues. Receiver operating characteristic analysis showed that the area-under-the curve values were 0.895, 0.885, and 0.919, while the positive predictive values were 95.8%, 95.6%, and 97.1%, for nuclear immunostaining for normal versus leukoplakia with no dysplasia, leukoplakic lesions with dysplasia, and OSCCs, respectively. Immunoblotting confirmed overexpression of TC21 in oral lesions. Using co-immunoprecipitation assays, we showed interactions of TC21 with Erk2, PI3-K, 14-3-3zeta and 14-3-3sigma proteins in oral cancer cells. Our findings suggested that alteration in TC21 expression is an early event in oral cancer and correlates with poor prognosis of OSCCs. TC21 interactions with Erk2, PI3-K, 14-3-3zeta and 14-3-3sigma proteins in oral cancer cells and tissues suggests the involvement of TC21 in signaling pathways in oral cancer.
Intermolecular interactions and the thermodynamic properties of supercritical fluids.
Yigzawe, Tesfaye M; Sadus, Richard J
2013-05-21
The role of different contributions to intermolecular interactions on the thermodynamic properties of supercritical fluids is investigated. Molecular dynamics simulation results are reported for the energy, pressure, thermal pressure coefficient, thermal expansion coefficient, isothermal and adiabatic compressibilities, isobaric and isochoric heat capacities, Joule-Thomson coefficient, and speed of sound of fluids interacting via both the Lennard-Jones and Weeks-Chandler-Andersen potentials. These properties were obtained for a wide range of temperatures, pressures, and densities. For each thermodynamic property, an excess value is determined to distinguish between attraction and repulsion. It is found that the contributions of intermolecular interactions have varying effects depending on the thermodynamic property. The maxima exhibited by the isochoric and isobaric heat capacities, isothermal compressibilities, and thermal expansion coefficient are attributed to interactions in the Lennard-Jones well. Repulsion is required to obtain physically realistic speeds of sound and both repulsion and attraction are necessary to observe a Joule-Thomson inversion curve. Significantly, both maxima and minima are observed for the isobaric and isochoric heat capacities of the supercritical Lennard-Jones fluid. It is postulated that the loci of these maxima and minima converge to a common point via the same power law relationship as the phase coexistence curve with an exponent of β = 0.32. This provides an explanation for the terminal isobaric heat capacity maximum in supercritical fluids.
NASA Astrophysics Data System (ADS)
Kant, Sunny; Panda, Jagabandhu; Pani, Shantanu Kumar; Wang, Pao K.
2018-05-01
This study attempts to analyze possible aerosol-cloud-precipitation interaction over the eastern part of India including Bhubaneswar city and the whole Odisha region primarily using a long-term satellite-based dataset from 2000 to 2016 during pre-monsoon period. Relationship between aerosol optical depth (AOD), rainfall, and cloud properties is examined by taking convectively driven rain events. The two-sample student's t test is used to compute "p" value of datasets that are statically significant. Role of aerosols in governing cloud properties is analyzed through the variation of COD (cloud optical depth) and CER (cloud effective radius) in the AOD ranges 0.2-0.8. A relatively stronger and affirmative AOD-CER relationship is observed over Bhubaneswar city compared to Odisha region though the aerosols still play an appreciable role for the later too. The AOD-COD relationship is weak over both the regions. For Odisha, relationships between aerosol and cloud parameters are insignificant irrespective of rainfall regimes. Fostering of heavy rainfall over these regions takes place due to invigoration and microphysical effect during pre-monsoon months, depending upon meteorological conditions. Liquid water content and presence of a mixed-phase zone, both seem to be quite important in the convectively driven precipitation over Odisha region including Bhubaneswar city.
Can outcomes of dyadic interactions be consistent across contexts among wild zebrafish?
Roy, Tamal; Bhat, Anuradha
2015-01-01
Winner–loser relations among group-living individuals are often measured by the levels of aggressive interactions between them. These interactions are typically driven by competition for resources such as food and mates. It has been observed in recent studies on zebrafish that dominant males generally have higher total reproductive success than their less aggressive subordinate counterparts. This study aimed to test whether males who monopolized a food resource (winners) also displayed higher levels of aggression than the males who were unsuccessful (losers). Further, the study also tested whether the same ‘winner’ males were also able to monopolize interactions with females during courtship. The results from these experiments showed that while males monopolizing food resources (winners) demonstrated higher levels of agonistic interactions than the losers, the average number of courtship interactions initiated by either of the males (i.e. winners/losers) with a female was not significantly different. A significant relationship was obtained between the number of aggressive interactions and feeding latencies of males in the context of food monopolization. This indicated that there could be a linkage between boldness defined by feeding latency in a novel environment and agonistic responses. The probable role of nature of resources, resource availability and distribution in determining the outcomes of dyadic contests is discussed. PMID:26715992
Garnier, Aurélie; Pennekamp, Frank; Lemoine, Mélissa; Petchey, Owen L
2017-12-01
Global environmental change has negative impacts on ecological systems, impacting the stable provision of functions, goods, and services. Whereas effects of individual environmental changes (e.g. temperature change or change in resource availability) are reasonably well understood, we lack information about if and how multiple changes interact. We examined interactions among four types of environmental disturbance (temperature, nutrient ratio, carbon enrichment, and light) in a fully factorial design using a microbial aquatic ecosystem and observed responses of dissolved oxygen saturation at three temporal scales (resistance, resilience, and return time). We tested whether multiple disturbances combine in a dominant, additive, or interactive fashion, and compared the predictability of dissolved oxygen across scales. Carbon enrichment and shading reduced oxygen concentration in the short term (i.e. resistance); although no other effects or interactions were statistically significant, resistance decreased as the number of disturbances increased. In the medium term, only enrichment accelerated recovery, but none of the other effects (including interactions) were significant. In the long term, enrichment and shading lengthened return times, and we found significant two-way synergistic interactions between disturbances. The best performing model (dominant, additive, or interactive) depended on the temporal scale of response. In the short term (i.e. for resistance), the dominance model predicted resistance of dissolved oxygen best, due to a large effect of carbon enrichment, whereas none of the models could predict the medium term (i.e. resilience). The long-term response was best predicted by models including interactions among disturbances. Our results indicate the importance of accounting for the temporal scale of responses when researching the effects of environmental disturbances on ecosystems. © 2017 The Authors. Global Change Biology Published by John Wiley
Interaction between adolescent obesity and HLA risk genes in the etiology of multiple sclerosis
Lima Bomfim, Izaura; Barcellos, Lisa; Gianfrancesco, Milena; Schaefer, Catherine; Kockum, Ingrid; Olsson, Tomas; Alfredsson, Lars
2014-01-01
Objective: We investigated potential interactions between human leukocyte antigen (HLA) genotype and body mass index (BMI) status in relation to the risk of developing multiple sclerosis (MS). Methods: We used 2 case-control studies, one with incident cases (1,510 cases, 2,017 controls) and one with prevalent cases (937 cases, 609 controls). Subjects with different genotypes and BMI were compared with regard to incidence of MS by calculating odds ratios (ORs) with 95% confidence intervals (CIs) employing logistic regression. Potential interactions between genotypes and BMI were evaluated by calculating the attributable proportion due to interaction. Results: In both cohorts, a significant interaction was observed between HLA-DRB1*15 and obesity, regardless of HLA-A*02 status. Similarly, there was a significant interaction between absence of A*02 and obesity, regardless of DRB1*15 status. In the incident cohort, obese subjects with the most susceptible genotype (carriage of DRB1*15 and absence of A*02) had an OR of 16.2 (95% CI 7.5–35.2) compared to nonobese subjects without the genetic risk factors. The corresponding OR in the prevalent study was 13.8 (95% CI 4.1–46.8). Conclusions: We observed striking interactions between BMI status and HLA genotype with regard to MS risk. Hypothetically, a low-grade inflammatory response inherent to obesity synergizes with the adaptive, HLA molecule–restricted arm of the immune system, causing MS. Prevention of adolescent obesity may thus lower the risk of developing MS, predominantly among people with a genetic susceptibility to the disease. PMID:24500647
Turbulence between two inline hemispherical obstacles under wave-current interactions
NASA Astrophysics Data System (ADS)
Barman, K.; Debnath, K.; Mazumder, B. S.
2016-02-01
This paper reports an experimental investigation of open channel turbulent flow between two inline surface mounted hemispherical obstacles in tandem arrangement. A series of experiments are performed under combined wave-current interaction with seven relative spacing L/h, where L is center to center spacing distance and h is the obstacle height for Reynolds number Re = 5.88 × 104. The observations are particularly focused on the changes induced in the mean velocity components, turbulence intensities and Reynolds shear stress due to superposition of surface waves on the ambient flow, and are compared to that of flat-surface and a single hemisphere. The paper also investigates the dominant turbulent bursting events that contribute to the Reynolds shear stress for different relative depth influenced by hemispheres. It is observed that the contributions to the total shear stress due to ejection and sweep are dominant at the wake region for single and double hemisphere near the bed, while towards the surface outward and inward interactions show significant effect for wave-current interactions which is largely different from that over the flat-surface case. Spectral analysis of the observed velocity fluctuations reveals the existence of two distinct power law scaling regime near the bed. At high frequency, an inertial sub-range of turbulence with -5/3 Kolmogorov scaling is observed for the flat-surface. The spectral slope is calculated to show the shifting of standard Kolmogorov scale for both only current and wave-induced tests.
Competing interactions in semiconductor quantum dots
van den Berg, R.; Brandino, G. P.; El Araby, O.; ...
2014-10-14
In this study, we introduce an integrability-based method enabling the study of semiconductor quantum dot models incorporating both the full hyperfine interaction as well as a mean-field treatment of dipole-dipole interactions in the nuclear spin bath. By performing free induction decay and spin echo simulations we characterize the combined effect of both types of interactions on the decoherence of the electron spin, for external fields ranging from low to high values. We show that for spin echo simulations the hyperfine interaction is the dominant source of decoherence at short times for low fields, and competes with the dipole-dipole interactions atmore » longer times. On the contrary, at high fields the main source of decay is due to the dipole-dipole interactions. In the latter regime an asymmetry in the echo is observed. Furthermore, the non-decaying fraction previously observed for zero field free induction decay simulations in quantum dots with only hyperfine interactions, is destroyed for longer times by the mean-field treatment of the dipolar interactions.« less
Portet, Anaïs; Pinaud, Silvain; Tetreau, Guillaume; Galinier, Richard; Cosseau, Céline; Duval, David; Grunau, Christoph; Mitta, Guillaume; Gourbal, Benjamin
2017-10-01
The fresh water snail Biomphalaria glabrata is one of the vectors of the trematode pathogen Schistosoma mansoni, which is one of the agents responsible of human schistosomiasis. In this host-parasite interaction, co-evolutionary dynamic results into an infectivity mosaic known as compatibility polymorphism. Integrative approaches including large scale molecular approaches have been conducted in recent years to improve our understanding of the mechanisms underlying compatibility. This review presents the combination of integrated Multi-Omic approaches leading to the discovery of two repertoires of polymorphic and/or diversified interacting molecules: the parasite antigens S. mansoni polymorphic mucins (SmPoMucs) and the B. glabrata immune receptors fibrinogen-related proteins (FREPs). We argue that their interactions may be major components for defining the compatible/incompatible status of a specific snail/schistosome combination. Copyright © 2017 Elsevier Ltd. All rights reserved.
Warfarin interaction with erythromycin.
Sato, R I; Gray, D R; Brown, S E
1984-12-01
The drug interaction between warfarin and erythromycin is not well known. We report a case in which erythromycin was observed to markedly potentiate warfarin anticoagulation, resulting in hemorrhage in a patient treated for Legionella pneumonia. The morbidity of this drug interaction is enhanced in elderly patients who have infection accompanied by anorexia and/or fever and who are receiving intravenous erythromycin. The well-documented, temporal relationship established erythromycin as the interacting drug.
Radio and X-Ray Observations of SN 2006jd: Another Strongly Interacting Type IIn Supernova
NASA Technical Reports Server (NTRS)
Chandra, Poonam; Chevalier, Roger A.; Chugai, Nikolai; Fransson, Claes; Irwin, Christopher M.; Soderberg, Alicia M.; Chakraborti, Sayan; Immler, Stefan
2012-01-01
We report four years of radio and X-ray monitoring of the Type IIn supernova SN 2006jd at radio wavelengths with the Very Large Array, Giant Metrewave Radio Telescope and Expanded Very Large Array at X-ray wavelengths with Chandra, XMM-Newton and Swift-XRT. We assume that the radio and X-ray emitting particles are produced by shock interaction with a dense circumstellar medium. The radio emission shows an initial rise that can be attributed to free-free absorption by cool gas mixed into the nonthermal emitting region external free-free absorption is disfavored because of the shape of the rising light curves and the low gas column density inferred along the line of sight to the emission region. The X-ray luminosity implies a preshock circumstellar density approximately 10(exp 6) per cubic meter at a radius r approximately 2 x 10(exp 16) centimeter, but the column density inferred from the photoabsorption of X-rays along the line of sight suggests a significantly lower density. The implication may be an asymmetry in the interaction. The X-ray spectrum shows Fe line emission at 6.9 keV that is stronger than is expected for the conditions in the X-ray emitting gas. We suggest that cool gas mixed into the hot gas plays a role in the line emission. Our radio and X-ray data both suggest the density profile is flatter than r2 because of the slow evolution of the unabsorbed emission.
Evaluation of drug interaction microcomputer software: Dambro's Drug Interactions.
Poirier, T I; Giudici, R A
1990-01-01
Dambro's Drug Interactions was evaluated using general and specific criteria. The installation process, ease of learning and use were rated excellent. The user documentation and quality of the technical support were good. The scope of coverage, clinical documentation, frequency of updates, and overall clinical performance were fair. The primary advantages of the program are the quick searching and detection of drug interactions, and the attempt to provide useful interaction data, i.e., significance and reference. The disadvantages are the lack of current drug interaction information, outdated references, lack of evaluative drug interaction information, and the inability to save or print patient profiles. The program is not a good value for the pharmacist but has limited use as a quick screening tool.
Volcanism-Climate Interactions
NASA Technical Reports Server (NTRS)
Walter, Louis S. (Editor); Desilva, Shanaka (Editor)
1991-01-01
The range of disciplines in the study of volcanism-climate interactions includes paleoclimate, volcanology, petrology, tectonics, cloud physics and chemistry, and climate and radiation modeling. Questions encountered in understanding the interactions include: the source and evolution of sulfur and sulfur-gaseous species in magmas; their entrainment in volcanic plumes and injection into the stratosphere; their dissipation rates; and their radiative effects. Other issues include modeling and measuring regional and global effects of such large, dense clouds. A broad-range plan of research designed to answer these questions was defined. The plan includes observations of volcanoes, rocks, trees, and ice cores, as well as satellite and aircraft observations of erupting volcanoes and resulting lumes and clouds.
Aerosol-Cloud Interactions and Cloud Microphysical Properties in the Asir Region of Saudi Arabia
NASA Astrophysics Data System (ADS)
Kucera, P. A.; Axisa, D.; Burger, R. P.; Li, R.; Collins, D. R.; Freney, E. J.; Buseck, P. R.
2009-12-01
In recent advertent and inadvertent weather modification studies, a considerable effort has been made to understand the impact of varying aerosol properties and concentration on cloud properties. Significant uncertainties exist with aerosol-cloud interactions for which complex microphysical processes link the aerosol and cloud properties. Under almost all environmental conditions, increased aerosol concentrations within polluted air masses will enhance cloud droplet concentration relative to that in unperturbed regions. The interaction between dust particles and clouds are significant, yet the conditions in which dust particles become cloud condensation nuclei (CCN) are uncertain. In order to quantify this aerosol effect on clouds and precipitation, a field campaign was launched in the Asir region, located adjacent to the Red Sea in the southwest region of Saudi Arabia. Ground measurements of aerosol size distributions, hygroscopic growth factors, CCN concentrations as well as aircraft measurements of cloud hydrometeor size distributions were observed in the Asir region in August 2009. The presentation will include a summary of the analysis and results with a focus on aerosol-cloud interactions and cloud microphysical properties observed during the convective season in the Asir region.
Acaricide, Fungicide and Drug Interactions in Honey Bees (Apis mellifera)
Johnson, Reed M.; Dahlgren, Lizette; Siegfried, Blair D.; Ellis, Marion D.
2013-01-01
Background Chemical analysis shows that honey bees (Apis mellifera) and hive products contain many pesticides derived from various sources. The most abundant pesticides are acaricides applied by beekeepers to control Varroa destructor. Beekeepers also apply antimicrobial drugs to control bacterial and microsporidial diseases. Fungicides may enter the hive when applied to nearby flowering crops. Acaricides, antimicrobial drugs and fungicides are not highly toxic to bees alone, but in combination there is potential for heightened toxicity due to interactive effects. Methodology/Principal Findings Laboratory bioassays based on mortality rates in adult worker bees demonstrated interactive effects among acaricides, as well as between acaricides and antimicrobial drugs and between acaricides and fungicides. Toxicity of the acaricide tau-fluvalinate increased in combination with other acaricides and most other compounds tested (15 of 17) while amitraz toxicity was mostly unchanged (1 of 15). The sterol biosynthesis inhibiting (SBI) fungicide prochloraz elevated the toxicity of the acaricides tau-fluvalinate, coumaphos and fenpyroximate, likely through inhibition of detoxicative cytochrome P450 monooxygenase activity. Four other SBI fungicides increased the toxicity of tau-fluvalinate in a dose-dependent manner, although possible evidence of P450 induction was observed at the lowest fungicide doses. Non-transitive interactions between some acaricides were observed. Sublethal amitraz pre-treatment increased the toxicity of the three P450-detoxified acaricides, but amitraz toxicity was not changed by sublethal treatment with the same three acaricides. A two-fold change in the toxicity of tau-fluvalinate was observed between years, suggesting a possible change in the genetic composition of the bees tested. Conclusions/Significance Interactions with acaricides in honey bees are similar to drug interactions in other animals in that P450-mediated detoxication appears to play an
Positron Interactions with Oriented Polymers and with Chiral Quartz Crystals
NASA Astrophysics Data System (ADS)
Wu, Fei
Positron annihilation in various materials has been applied to characterize microstructure for decades. In this work, PALS was used to study material nanostructure, with a focus on the size and density of free volume and hole relaxation properties in polycarbonate (PC) and polymethylmethacrylate (PMMA); fundamental studies of polarized positron interaction with chiral crystals were also studied. Free volume relaxation in PC and PMMA with different levels of simple shear orientation was studied by PALS. Effects of applied pressure on the free volume recovery were evaluated. Combining the bulk- and pressure-dependent PALS analyses, the removal of applied pressure led to free-volume relaxation in all samples studied. The alignment of the polymer chains and free-volume holes imposes molecular restrictions on the molecular mobility of both PC and PMMA in their glassy states. Results indicated that the relaxation of the free volume holes at temperatures below glass transition is mostly reversible. Longitudinally polarized positron particles were used to reveal asymmetric interactions in chiral quartz crystals. Experimental results showed a significant intensity difference in free positronium annihilation for left handed (LH) and right handed (RH) chiral quartz crystals. Doppler broadening energy spectra (DBES) of z-cut LH or RH quartz disks at different angles were also measured by an "S parameter" to probe the observed difference. It was found that obtained annihilation energy difference of DBES was in agreement with the result of positron annihilation in bulk chiral crystals. PALS was used to compare different orientations and confirm asymmetric interactions in natural versus synthetic quartz LH and RH crystals in z and non-z orientations. Significant lifetime and intensity differences in free positronium annihilation for LH and RH quartz crystals were observed. The trend was found to be same in the related crystallographic orientations of the LH or RH crystals; the
Kinetic Interactions Between the Solar Wind and Lunar Magnetic Fields
NASA Astrophysics Data System (ADS)
Halekas, J. S.; Poppe, A. R.; Fatemi, S.; Turner, D. L.; Holmstrom, M.
2016-12-01
Despite their relatively weak strength, small scale, and incoherence, lunar magnetic anomalies can affect the incoming solar wind flow. The plasma interaction with lunar magnetic fields drives significant compressions of the solar wind plasma and magnetic field, deflections of the incoming flow, and a host of plasma waves ranging from the ULF to the electrostatic range. Recent work suggests that the large-scale features of the solar wind-magnetic anomaly interactions may be driven by ion-ion instabilities excited by reflected ions, raising the possibility that they are analogous to ion foreshock phenomena. Indeed, despite their small scale, many of the phenomena observed near lunar magnetic anomalies appear to have analogues in the foreshock regions of terrestrial planets. We discuss the charged particle distributions, fields, and waves observed near lunar magnetic anomalies, and place them in a context with the foreshocks of the Earth, Mars, and other solar system objects.
Troth, Erin E Gunnink; Johnston, Jeffrey A; Dyer, Alan T
2018-02-01
Among root pathogens, one of the most documented antagonisms is the suppression of Cochliobolus sativus by Fusarium (roseum) species. Unfortunately, previous studies involved single isolates of each pathogen and thus, provided no indication of the spectrum of responses that occur across the respective species. To investigate the variability in interactions between Cochliobolus sativus and Fusarium pseudograminearum, field and greenhouse trials were conducted that included monitoring of spring wheat plant health and monitoring of pathogen populations via quantitative real-time polymerase chain reaction. The interactions between two isolates of C. sativus and four isolates of F. pseudograminearum were explored in three geographically distinct wheat fields. To complement field trials and to limit potentially confounding environmental variables that are often associated with field studies, greenhouse trials were performed that investigated the interactions among and between three isolates of C. sativus and four isolates of F. pseudograminearum. Across field locations, C. sativus isolate Cs2344 consistently and significantly reduced Fusarium populations by an average of 20.1%. Similarly, F. pseudograminearum isolate Fp2228 consistently and significantly reduced C. sativus field populations by an average of 30.9%. No interaction was detected in the field between pathogen species with regards to disease or crop losses. Greenhouse results confirmed a powerful (>99%), broadly effective suppression of Fusarium populations by isolate Cs2344. Among greenhouse trials, additional isolate-isolate interactions were observed affecting Fusarium populations. Due to lower C. sativus population sizes in greenhouse trials, significant Fusarium suppression of C. sativus was only detected in one isolate-isolate interaction. This study is the first to demonstrate suppression of Fusarium spp. by C. sativus in field and greenhouse settings. These findings also reveal a complex competitive
Gannon, Matthew A.; Brown, Clifford J.; Stevens, Rachel M.; Griffith, Molly S.; Marczinski, Cecile A.; Bardgett, Mark E.
2015-01-01
Risperidone is an antipsychotic drug that is approved for use in childhood psychiatric disorders such as autism. One concern regarding the use of this drug in pediatric populations is that it may interfere with social interactions that serve to nurture brain development. This study used rats to assess the impact of risperidone administration on maternal-offspring interactions and juvenile play fighting between cage mates. Mixed-sex litters received daily subcutaneous injections of vehicle or 1.0 or 3.0 mg/kg of risperidone between postnatal days (PNDs) 14-42. Rats were weaned and housed three per cage on PND 21. In observations made between PNDs 14-17, risperidone significantly suppressed several aspects of maternal-offspring interactions at one-hour post-injection. At 23 hours post-injection, pups administered risperidone had lower activity scores and made fewer non-nursing contacts with their moms. In observations of play-fighting behavior made once a week between PNDs 22-42, risperidone profoundly decreased many forms of social interaction at one hour post-injection. At 23 hours post-injection, rats administered risperidone made more non-social contacts with their cage mates, but engaged in less social grooming. Risperidone administration to rats at ages analogous to early childhood through adolescence in humans produces a pattern of abnormal social interactions across the day that could impact how such interactions influence brain development. PMID:25600754
Network of Spaces and Interaction-Related Behaviors in Adult Intensive Care Units
Rashid, Mahbub; Boyle, Diane K.; Crosser, Michael
2014-01-01
Using three spatial network measures of “space syntax”, this correlational study describes four interaction-related behaviors among three groups of users in relation to visibility and accessibility of spaces in four adult intensive care units (ICUs) of different size, geometry, and specialty. Systematic field observations of interaction-related behaviors show significant differences in spatial distribution of interaction-related behaviors in the ICUs. Despite differences in unit characteristics and interaction-related behaviors, the study finds that when nurses and physicians “interact while sitting” they prefer spaces that help maintain a high level of environmental awareness; that when nurses “walk” and “interact while walking” they avoid spaces with better global access and visibility; and that everyone in ICUs “walk” more in spaces with higher control over neighboring spaces. It is argued that such consistent behavioral patterns occur due to the structural similarities of spatial networks over and above the more general functional similarities of ICUs. PMID:25469838
Interacting supernovae and supernova impostors
NASA Astrophysics Data System (ADS)
Tartaglia, Leonardo
2016-02-01
Massive stars are thought to end their lives with spectacular explosions triggered by the gravitational collapse of their cores. Interacting supernovae are generally attributed to supernova explosions occurring in dense circumstellar media, generated through mass-loss which characterisie the late phases of the life of their progenitors. In the last two decades, several observational evidences revealed that mass-loss in massive stars may be related to violent eruptions involving their outer layers, such as the luminous blue variables. Giant eruptions of extragalactic luminous blue variables, similar to that observed in Eta Car in the 19th century, are usually labelled 'SN impostors', since they mimic the behaviour of genuine SNe, but are not the final act of the life of the progenitor stars. The mechanisms producing these outbursts are still not understood, although the increasing number of observed cases triggered the efforts of the astronomical community to find possible theoretical interpretations. More recently, a number of observational evidences suggested that also lower-mass stars can experience pre-supernova outbursts, hence becoming supernova impostors. Even more interestingly, there is growing evidence of a connection among massive stars, their outbursts and interacting supernovae. All of this inspired this research, which has been focused in particular on the characterisation of supernova impostors and the observational criteria that may allow us to safely discriminate them from interacting supernovae. Moreover, the discovery of peculiar transients, motivated us to explore the lowest range of stellar masses that may experience violent outbursts. Finally, the quest for the link among massive stars, their giant eruptions and interacting supernovae, led us to study the interacting supernova LSQ13zm, which possibly exploded a very short time after an LBV-like major outburst.