Science.gov

Sample records for observing successive generations

  1. [Procreation and the succession of generations].

    PubMed

    Souza, G A

    1994-01-01

    "This article presents a complex conceptual and methodological proposal.... The study proposes an analysis similar and complementary to the abstract models of formal demography. Specifically, the article considers the practices and strategies of procreation, as well as the subjectiveness of people as constitutive elements of a succession of generations, as observed on different analytical levels." (SUMMARY IN ENG)

  2. Concluding Observations on Successful Partnerships.

    ERIC Educational Resources Information Center

    Spangler, Mary S.

    2002-01-01

    States that most successful partnerships between community colleges and business and industry have several common elements, and that they also face certain consistent challenges that must be overcome if they are to persist and flourish. Discusses the types of challenges experienced and elements necessary for establishing a successful partnership.…

  3. Frontonasal dysostosis in two successive generations.

    PubMed

    Nevin, N C; Leonard, A G; Jones, B

    1999-11-26

    Frontonasal dysostosis (also called frontonasal "dysplasia") comprises ocular hypertelorism, median facial cleft affecting nose and/or upper lip, unilateral or bilateral cleft of the alae nasi, anterior cranium bifidum occultum, or a widow's peak. Usually it is a sporadic disorder, although a few familial cases have been reported. We describe a 2-year-old girl with anterior cranium bifidum occultum, lipoma of genu and anterior part of the corpus callosum, and hypertelorism. Her mother had a history of a nasal drip at birth caused by a defect in the cribriform plate and phenotypically, a widow's peak. This observation suggests either autosomal dominant or X-linked dominant inheritance. The family illustrates the importance of identifying mild expression of frontonasal dysostosis before genetic counseling.

  4. Traveling excitable waves successively generated in a nonlinear proliferation system

    NASA Astrophysics Data System (ADS)

    Odagiri, Kenta; Takatsuka, Kazuo

    2009-05-01

    We study the dynamics of spatiotemporal pattern formation in a nonlinear proliferation system (e.g., cell division supported on a field of nutrition), in which the mechanism of activation and its self-suppression is simultaneously implemented. This dynamical model has been numerically realized with coupled cellular automata (CA), and various long-standing spatiotemporal patterns have been observed. Among others, a successive generation of traveling waves by implanting a spot of cells onto the field consisting of nutrition and activator is particularly interesting. This takes place despite the fact that the present reaction network has a stable fixed point and therefore autonomous temporal oscillatory does not exist in the mean field. Indeed, the reaction-diffusion equation method (RD) applied to this network reproduces only a single excitable wave and soon falls into a steady state (a fixed point) without the following propagating waves. This system, having a stable fixed point, is an excitable system of different kind from the FitzHugh-Nagumo model in that it can generate a pulse propagating outwards by adding only a single cell onto it from outside the system. The present excitation upon dropping a cell is amplified to macroscopic level by a hidden dynamics of oscillation between the activation and its self-suppression. A pulse thus generated is propagated in space time with the help of diffusion. Through a precise comparison between CA and RD, it is found that a very small amount of residue of the cells and activators, which are left unburned in the stochastic treatment of reactions by the CA, becomes a seed to excite the system and generate the next pulse wave. This newly born wave can leave another seed of reaction in the field after its propagation. Based on this analysis, we account for the appearance of other patterns observed. A possible control of these patterns by varying the spatial distribution of initial concentration of the relevant agents such as

  5. Successful Aging, Life Satisfaction, and Generativity in Later Life.

    ERIC Educational Resources Information Center

    Fisher, Bradley J.

    1995-01-01

    Explores meanings older people attach to successful aging and life satisfaction and to differentiate these concepts. Content analysis of an open-ended survey confirmed five features of successful aging: interactions with others, a sense of purpose, self-acceptance, personal growth, and autonomy. Findings suggest generativity contributes to…

  6. Defining generations in succession planning: there are four!

    PubMed

    Cadmus, Edna

    2002-12-01

    Never before have nursing leaders been faced with 4 generations of nurses working together, a turbulent health care system, and supply and demand issues. Succession planning with different generations requires a knowledge of their values and strengths. It means retaining and attracting new employees who can stabilize an organization.

  7. First Generation College Students in STEM: Counter Stories of Success

    NASA Astrophysics Data System (ADS)

    Hernandez, Carol D.

    First-generation community college Science, Technology, Engineering, and Mathematics (STEM) students have unique challenges in transferring to a four-year college. This is especially true for Latin and African American students who may experience multiple challenges, including discrimination, immigration issues and language issues, and sometimes poor academic preparation in their K-12 education. This project used a grounded theory approach to explore through an equity lens the educational journey of seven Los Medanos College students who have successfully transferred to a four-year institution were interviewed. All of these students that participated in this project were former Mathematics Engineering Science Achievement Program (MESA) students at Los Medanos College. The MESA Program is a learning community that provides academic support for "educationally and economically disadvantaged" students so they can excel in math and science, transfer to four-year institutions as majors in math-based fields, and graduate with baccalaureate degrees in STEM majors. Several intervention strategies are embedded into the program, including: counseling, mentors, a learning center, tutors, financial aid and transfer workshops, and internship and scholarship opportunities. The students were interviewed and asked several questions regarding their high school life, MESA, and community college and transfer experiences. The main theoretical framework utilized to analyze the interviews was Border Lands theory because these students created a safe space that allowed them to straddle their life at home and their life at school. Interviews with these students reveal seven successful, happy, and engaged students. Several themes emerged with respect to the importance of students' finding a major that they love, finding community, and the importance of teachers, family, and engagement in their success. The results of this project also emphasize the importance of hiring passionate teachers

  8. GRISO: Spatial Interpolation Generator from Rainfall Observations

    NASA Astrophysics Data System (ADS)

    Rebora, Nicola; Pignone, Flavio; Silvestro, Francesco

    2015-04-01

    The estimation of rainfall fields, especially its spatial distribution and position is a crucial task both for rainfall nowcasting and for modeling catchment response to rainfall. In the past years several studies on the spatialization of rainfall from raingauge were made and many mathematical methods to cope with this problem were developed. The most known is the Kriging (Matheron, 1967). A new geostatistical algorithm called GRISO (Spatial Interpolation Generator from Rainfall Observations) was implemented. The GRISO method, similar to Kriging, was developed in order that the output map maintains the observed "real" rainfall value on the raingauges position but is conditioned to reach the mean of the field far from the gauges. The main innovation is the improved computational time, the associated map of variance and above all the possibility of using more than one semivariogram for spatialize the information. The GRISO algorithm has been applied is Italy, where is available a dense network of raingauges (about 3000 stations). A validation of the GRISO method was done on a large number of Italian past events. Several statistical scores have been applied to compare it with Kriging. The new algorithm is operationally used by the Italian Civil Protection Department.

  9. Dynamics of Rocky Mountain Lee Waves Observed During Success

    NASA Technical Reports Server (NTRS)

    Dean-Day, J.; Chan, K. R.; Bowen, S. W.; Bui, T. P.; Gary, B. L.; Chan, K. Roland (Technical Monitor)

    1997-01-01

    On two days during SUCCESS, the DC-8 sampled wave clouds which formed downstream of the ridges east of the Rocky Mountains. Wave morphology for both flights is deduced from temperature and 3-dimensional wind measurements from the MMS, isentrope profiles from the MTP, and linear perturbation theory. The waves observed on 960430 are smaller and found to be decaying with altitude, while the waves sampled on 960502 are vertically propagating and consist of larger, multiple wave scales. Wave orientations are consistent with the underlying topography and regions of high ice crystal concentration. Updraft velocities were estimated from the derived wave properties and are consistent with MMS vertical winds.

  10. Tracking neural correlates of successful learning over repeated sequence observations

    PubMed Central

    Steinemann, Natalie A.; Moisello, Clara; Ghilardi, M. Felice; Kelly, Simon P.

    2016-01-01

    The neural correlates of memory formation in humans have long been investigated by exposing subjects to diverse material and comparing responses to items later remembered to those forgotten. Tasks requiring memorization of sensory sequences afford unique possibilities for linking neural memorization processes to behavior, because, rather than comparing across different items of varying content, each individual item can be examined across the successive learning states of being initially unknown, newly learned, and eventually, fully known. Sequence learning paradigms have not yet been exploited in this way, however. Here, we analyze the event-related potentials of subjects attempting to memorize sequences of visual locations over several blocks of repeated observation, with respect to pre- and post-block recall tests. Over centro-parietal regions, we observed a rapid P300 component superimposed on a broader positivity, which exhibited distinct modulations across learning states that were replicated in two separate experiments. Consistent with its well-known encoding of surprise, the P300 deflection monotonically decreased over blocks as locations became better learned and hence more expected. In contrast, the broader positivity was especially elevated at the point when a given item was newly learned, i.e., started being successfully recalled. These results implicate the Broad Positivity in endogenously-driven, intentional memory formation, whereas the P300, in processing the current stimulus to the degree that it was previously uncertain, indexes the cumulative knowledge thereby gained. The decreasing surprise/P300 effect significantly predicted learning success both across blocks and across subjects. This presents a new, neural-based means to evaluate learning capabilities independent of verbal reports, which could have considerable value in distinguishing genuine learning disabilities from difficulties to communicate the outcomes of learning, or perceptual

  11. Six Years Observation After Successful Treatment of Bacterial Vaginosis

    PubMed Central

    Påhlson, Carl; Larsson, P.-G.

    1997-01-01

    Objective: The cure rate after treatment of bacterial vaginosis (BV) differs in various investigations, but most studies report a cure rate of 70% after 1 month. Methods: A long-term observation study after successful treatment of BV has been undertaken. The original study was a treatment study of BV and included 50 patients. Results: We were able to identify 44 of the original 50 patients. The mean follow-up time was 6.9 years (range 4.7–9 years). During this time, 21 women (48%) had been free of BV while 23 women had had relapses. There was no difference in the use of broad-spectrum antibiotics, episodes of candida vaginitis, bleeding disturbances, family planning method, development of cervical intraepithelial neoplasia (CIN), or gynecological operations between women with and without relapses. The women with relapses had had a new sexual contact more often during the observation period than women without relapses. There was no difference in hydrogen peroxide production of the lactobacilli among women with or without relapses, and survival analysis shows that most relapses occur during the first year after treatment. Conclusions: If patients are successfully treated, half of the patients will stay cured indicating that treatment is of benefit. Most relapses occur during the first year. Our results indicate that the etiology of BV might have something to do with new sexual contacts. PMID:18476155

  12. Trigger of Successive Filament Eruptions Observed by SDO and STEREO

    NASA Astrophysics Data System (ADS)

    Dhara, Sajal Kumar; Belur, Ravindra; Kumar, Pankaj; Banyal, Ravinder Kumar; Mathew, Shibu K.; Joshi, Bhuwan

    2017-10-01

    Using multiwavelength observations from the Solar Dynamics Observatory (SDO) and the Solar Terrestrial Relations Observatory (STEREO), we investigate the mechanism of two successive eruptions (F1 and F2) of a filament in active region NOAA 11444 on 27 March 2012. The filament was inverse J-shaped and lay along a quasi-circular polarity inversion line (PIL). The first part of the filament erupted at ˜2{:}30 UT on 27 March 2012 (F1), the second part at around 4:20 UT on the same day (F2). A precursor or preflare brightening was observed below the filament main axis about 30 min before F1. The brightening was followed by a jet-like ejection below the filament, which triggered its eruption. Before the eruption of F2, the filament seemed to be trapped within the overlying arcade loops for almost 1.5 h before it successfully erupted. Interestingly, we observe simultaneously contraction (˜12 km s^{-1}) and expansion (˜20 km s^{-1}) of arcade loops in the active region before F2. Magnetograms obtained with the Helioseismic and Magnetic Imager (HMI) show converging motion of the opposite polarities, which result in flux cancellation near the PIL. We suggest that flux cancellation at the PIL resulted in a jet-like ejection below the filament main axis, which triggered F1, similar to the tether-cutting process. F2 was triggered by removal of the overlying arcade loops via reconnection. Both filament eruptions produced high-speed (˜1000 km s^{-1}) coronal mass ejections.

  13. Do new generation flexible ureterorenoscopes offer a higher treatment success than their predecessors?

    PubMed

    Wendt-Nordahl, Gunnar; Mut, Tuna; Krombach, Patrick; Michel, Maurice Stephan; Knoll, Thomas

    2011-06-01

    New generation flexible ureterorenoscopes offer an improved deflection mechanism and a stiffer sheath compared to their predecessors. We aimed to determine if these improvements in design lead to a higher efficacy in the treatment of nephrolithiasis. Ninety patients with upper urinary tract calculi were included into a retrospective analysis. Twenty-nine cases were treated with the conventional flexible ureterorenoscope (11274 AA, Karl Storz Endoscopy, Germany) and 61 cases were treated with the new generation device (Flex-X, Karl Storz Endoscopy). Patients' and stone characteristics, intraoperative data, treatment success and complications were retrieved from the charts and compared between the two groups. Preoperative data were comparable in both groups. Whereas stone access was also comparable (97 vs. 100%; n.s.), immediate treatment success was significantly higher for the new flexible scope (70 vs. 38%; p = 0.003). For the subgroup of lower pole stones, stone access was possible in 94 versus 100% (n.s.) and treatment success was 31 versus 69% (p = 0.0004) for the conventional and the new generation device, respectively. No major complications were observed, minor complications were comparable in both groups. Our study suggests an advantage of the new generation flexible ureterorenoscopes compared to their predecessors. They offer an increased stone free rate especially in the treatment of lower pole stones. It seems therefore advisable to switch to the latest generation flexible devices.

  14. Classification Objects, Ideal Observers & Generative Models

    ERIC Educational Resources Information Center

    Olman, Cheryl; Kersten, Daniel

    2004-01-01

    A successful vision system must solve the problem of deriving geometrical information about three-dimensional objects from two-dimensional photometric input. The human visual system solves this problem with remarkable efficiency, and one challenge in vision research is to understand how neural representations of objects are formed and what visual…

  15. Chronic effects of carbamazepine on life-history strategies of Ceriodaphnia dubia in three successive generations.

    PubMed

    Lamichhane, Kiran; Garcia, Santos N; Huggett, Duane B; DeAngelis, Donald L; La Point, Thomas W

    2013-04-01

    Trace quantities of pharmaceuticals are continuously being discharged into the environment through domestic and industrial wastewater effluents, causing concern among scientists and regulators regarding potential long-term impacts on aquatic ecosystems. These compounds and their metabolites are constantly interacting with organisms at various life-cycle stages and may differentially influence the development of embryonic, larval, juvenile, and adult stages. To understand the possible cumulative effects of exposure to carbamazepine (CBZ), a multigenerational approach was taken in which survival, reproduction, respiration, growth, brood size, and biomass of Ceriodaphnia dubia were assessed at sublethal concentrations over the course of three successive generations. CBZ exposure significantly decreased fecundity at 196.7 μg/L in the F0 and F1 generations over 2 weeks and acclimatized at 264.6 μg/L in the F2 generation. Similarly, a significant decrease of neonate dry weight was observed at the 196.7 μg/L CBZ treatment in the F1 generation, and it acclimatized at 264.6 μg/L treatment level in the F2 generation. Median time to first brood release was significantly delayed at 264.6 μg/L in the F2 generation, indicating slower maturation. Results over three successive generations are not different than what one would obtain by testing simply the F0 generation. Furthermore, the effects measured were observed at concentrations two orders of magnitude higher than are environmentally relevant, and it is unlikely that CBZ poses a substantial risk to the environment regarding the end points measured in this study. However, additional research through laboratory and field multigenerational studies may be required to understand the overall risk of CBZ to other nontarget organisms.

  16. Training a New Generation of Biostatisticians: A Successful Consortium Model

    ERIC Educational Resources Information Center

    Simpson, Judy M.; Ryan, Philip; Carlin, John B.; Gurrin, Lyle; Marschner, Ian

    2009-01-01

    In response to the worldwide shortage of biostatisticians, Australia has established a national consortium of eight universities to develop and deliver a Masters program in biostatistics. This article describes our successful innovative multi-institutional training model, which may be of value to other countries. We first present the issues…

  17. Training a New Generation of Biostatisticians: A Successful Consortium Model

    ERIC Educational Resources Information Center

    Simpson, Judy M.; Ryan, Philip; Carlin, John B.; Gurrin, Lyle; Marschner, Ian

    2009-01-01

    In response to the worldwide shortage of biostatisticians, Australia has established a national consortium of eight universities to develop and deliver a Masters program in biostatistics. This article describes our successful innovative multi-institutional training model, which may be of value to other countries. We first present the issues…

  18. All Eyes on Nepal - A Success Case for Integrated Observations

    NASA Astrophysics Data System (ADS)

    Cox, E. L., Jr.

    2015-12-01

    When hazards are known it is not a question of if but when the disaster shock will happen and it is critical that all relevant observational data, tools and technologies be accessible and integrated by experts and volunteers to provide reliable, timely and actionable information. In this talk NASA's coordinated response to the recent Nepal "Gorkha" will be presented as a case study to highlight the opportunities and challenges. Triggered by a global seismic network and the interpretation by operational, research and response agencies, all available assets were quickly mobilized, charters activated to share data, and information gathered to assess impacts. This included assessing available data from optical and radar-based satellites and global positioning systems to baseline pre-event conditions and distinguish immediate and ongoing changes. Models and maps were generated to identify land deformation and damage proxies for communities, resources and infrastructure. Technologies facilitated national and international collaboration among public and private sector institutions to task satellites and optimize integration and processing of data from vital airborne platforms or ingest relevant new data streams. Crowd-sourced data added to the mix and provided a critical source of ground truth that blended with reports from field teams and those in communities. New levels of situational awareness were achieved through integrated data products and the reliance on relationships and new technologies that allowed for volunteers to analyze results in an unprecedented fashion. The results demonstrated how science aided by emerging technologies is changing our implementation of disaster response.

  19. Remote sensing observations of phytoplankton increases triggered by successive typhoons

    NASA Astrophysics Data System (ADS)

    Huang, Lei; Zhao, Hui; Pan, Jiayi; Devlin, Adam

    2016-11-01

    Phytoplankton blooms in the Western North Pacific, triggered by two successive typhoons with different intensities and translation speeds under different pre-existing oceanic conditions, were observed and analyzed using remotely sensed chlorophyll-a (Chl-a), sea surface temperature (SST), and sea surface height anomaly (SSHA) data, as well as typhoon parameters and CTD (conductivity, temperature, and depth) profiles. Typhoon Sinlaku, with relatively weaker intensity and slower translation speed, induced a stronger phytoplankton bloom than Jangmi with stronger intensity and faster translation speed (Chl-a>0.18 mg•m‒3 versus Chla<0.15 mg•m‒3) east of Taiwan Island. Translation speed may be one of the important mechanisms that affect phytoplankton blooms in the study area. Pre-existing cyclonic circulations provided a relatively unstable thermodynamic structure for Sinlaku, and therefore cold water with rich nutrients could be brought up easily. The mixed-layer deepening caused by Typhoon Sinlaku, which occurred first, could have triggered an unfavorable condition for the phytoplankton bloom induced by Typhoon Jangmi which followed afterwards. The sea surface temperature cooling by Jangmi was suppressed due to the presence of the thick upper-ocean mixed-layer, which prevented the deeper cold water from being entrained into the upper-ocean mixed layer, leading to a weaker phytoplankton augment. The present study suggests that both wind (including typhoon translation speed and intensity) and pre-existing conditions (e.g., mixedlayer depths, eddies, and nutrients) play important roles in the strong phytoplankton bloom, and are responsible for the stronger phytoplankton bloom after Sinlaku's passage than that after Jangmi's passage. A new typhooninfluencing parameter is introduced that combines the effects of the typhoon forcing (including the typhoon intensity and translation speed) and the oceanic precondition. This parameter shows that the forcing effect of

  20. Observation of Magnetic Fields Generated by Tsunamis

    NASA Astrophysics Data System (ADS)

    Manoj, Chandrasekharan; Maus, Stefan; Chulliat, Arnaud

    2011-01-01

    Tsunamis produce perturbations in the Earth's magnetic field by electromagnetic induction. Recent deployments of highly accurate magnetometers and the exceptionally deep solar minimum provided ideal conditions to observe these small signals from the tsunami resulting from the strong Chilean earthquake on 27 February 2010. Magnetic observatory measurements on Easter Island, 3500 kilometers west of the epicenter, show a periodic signal of 1 nanotesla, coincident in time with recordings from the local tide gauge. The detection of these magnetic signals represents a milestone in understanding tsunami-induced electromagnetic effects.

  1. Recognizing Challenges and Predicting Success in First-Generation University Students

    ERIC Educational Resources Information Center

    Katrevich, Alina V.; Aruguete, Mara S.

    2017-01-01

    Our study explores the challenges of first-generation students while also examining the factors that predict success in this population. We surveyed undergraduate students to compare the academic and social support needs of first-generation and continuing-generation students. First-generation students showed lower grades and critical-thinking…

  2. Can failure carefully observed become a springboard to success?

    PubMed

    Adrian, Manuella

    2012-01-01

    Since its inception, the addictions field has had a history of failure: failures in conceptualizations, in treatment, in interventions, in policies, in process as well as outcome assessment. Certain actions and activities have had a less than stellar effect which may lead to feelings of personal failure among practitioners, the tagging of processes and programs as being failures when they are not so, as well as an identification of the person being intervened with, by self and others, as being a failure or loser. This paper discusses how to define success and failure and the need to identify both the short(er) and long(er) term, as well as temporary and permanent effects, including the implications of using binary (success or failure; success and failure) and nonbinary (and in addition) categories of assessment. The need to clarify expectations and to establish goals and measurable effects are noted. Being open to accepting results which may be personally disappointing, initially, but which offer opportunities for needed changes may lead to new developments in the field and the establishment of better interventions.

  3. Mopra remote observing: a story of innovation and success

    NASA Astrophysics Data System (ADS)

    Indermuehle, Balthasar T.; Edwards, Philip G.

    2010-07-01

    The Mopra Radio Telescope is a 22m single-dish radio telescope located near Siding Spring Observatory in New South Wales, Australia. Its receiver systems cover the 3mm, 7mm and 12mm bands for single-dish observing, as well as the 6/3cm and 20/13cm bands used for Very Long Baseline Interferometry (VLBI). The remote location of the telescope, a good day's drive from Sydney, made it a good candidate to implement remote observing capabilities which would no longer require observers to travel to the telescope, but bring the telescope to them. In a first step this was implemented in a controlled environment three years ago. It enabled remote observing from a dedicated workstation at the Australia Telescope Compact Array (ATCA) control building some 160km away from the observatory. In a second step two years ago, remote observing was extended to allow observing from any location in the world for qualifying observers. There were a number of challenges that needed to be addressed, from telescope safety to internet and data link reliability, computer security, and providing the observers with adequate situation awareness tools. The uptake by observers has been very good with over 40% of the observing in 2009 having been executed remotely. Further, many small and unallocated time slices were able to be productively used as they would not have warranted a trip to the observatory in their own merit but were usable thanks to remote observing. This helped push the productivity of the Mopra telescope in 2009 to the highest figure in its 17 year history.

  4. Generational forecasting in academic medicine: a unique method of planning for success in the next two decades.

    PubMed

    Howell, Lydia Pleotis; Joad, Jesse P; Callahan, Edward; Servis, Gregg; Bonham, Ann C

    2009-08-01

    Multigenerational teams are essential to the missions of academic health centers (AHCs). Generational forecasting using Strauss and Howe's predictive model, "the generational diagonal," can be useful for anticipating and addressing issues so that each generation is effective. Forecasts are based on the observation that cyclical historical events are experienced by all generations, but the response of each generation differs according to its phase of life and previous defining experiences. This article relates Strauss and Howe's generational forecasts to AHCs. Predicted issues such as work-life balance, indebtedness, and succession planning have existed previously, but they now have different causes or consequences because of the unique experiences and life stages of current generations. Efforts to address these issues at the authors' AHC include a work-life balance workgroup, expanded leave, and intramural grants.

  5. Successful observation of Schottky signals at the Tevatron collider

    SciTech Connect

    Goldberg, D.A.; Lambertson, G.R.

    1989-08-01

    We have constructed a Schottky detector for the Tevatron collider in the form of a high-Q ({approx}5000) cavity which operates at roughly 2 GHz, well above the frequency at which the Tevatron's single-bunch frequency spectrum begins to roll off. Initial spectra obtained from the detector show clearly observable Schottky betatron lines, free of coherent contaminants; also seen are the common-mode'' longitudinal signals due to the offset of the beam from the detector center. The latter signals indicate that at 2 GHz, the coherent single-bunch spectrum from the detector is reduced by >80 dB; therefore, in normal collider operation, the Schottky betatron lines are >40 dB greater than their coherent counterparts. We describe how the data we have obtained give information on transverse and longitudinal emittances, synchrotron frequency, and betatron tunes, as well as reveal what may be previously unobserved phenomena. Space limitations restrict us to presenting only as much data as should be necessary to convince even the skeptical reader of the validity of the claim made in the paper's title. 3 refs., 2 figs.

  6. Choosing Success: A Paradigm for Empowering First-Generation College Students

    ERIC Educational Resources Information Center

    Macias, Louis V.

    2013-01-01

    Louis V. Macias reminds us that educators' attitudes toward first-generation students have a great impact on their eventual success … or failure. Are you serving the best interests of your students with an inspirational, success-oriented mind-set that considers all of their capabilities?

  7. A Phenomenological Investigation of the Lived Experiences of Successful First Generation Hispanic College Students

    ERIC Educational Resources Information Center

    Puente, Christina C.

    2013-01-01

    This qualitative phenomenological research study investigated the lived experiences of five successful first generation Hispanic college students. Participants' interviews were analyzed using Creswell's (2007) six steps for analyzing phenomenological studies. Findings from this study affirm the factors for student success in college regarding…

  8. Self-Determination, Success, and College Readiness of First Generation Students in a Higher Education Institution

    ERIC Educational Resources Information Center

    Ochoa, Manuel

    2012-01-01

    The purpose of the study was to describe and compare if self-determination factors differed in first and non-first generation college students and success levels. Additionally, comparisons of college readiness levels were measured, and finally a measure of factors that contribute to college success based in first and second semester grade point…

  9. Climatology of successive equatorial plasma bubbles observed by GPS ROTI over Malaysia

    NASA Astrophysics Data System (ADS)

    Buhari, S. M.; Abdullah, M.; Yokoyama, T.; Otsuka, Y.; Nishioka, M.; Hasbi, A. M.; Bahari, S. A.; Tsugawa, T.

    2017-02-01

    The occurrence rate of the equatorial plasma bubble (EPB) with season, solar activity, and geomagnetic conditions are investigated using long-term data sets of Malaysia Real-Time Kinematics Network (MyRTKnet) from 2008 to 2013. The rate of TEC (total electron content) change index (ROTI) in 5 min was derived from MyRTKnet data to detect the EPB with scale sizes around tens of kilometers. Then, the daily east-west cross sections of 2-D ROTI maps were used to examine the EPB features over 100°E-119°E longitudes. The EPBs tend to occur successively in one night along the observational coverage of MyRTKnet during equinoxes in high solar activity years. The perturbations in a form of wavelike structures along the observed longitudes might be responsible for the development of successive EPBs due to high growth rate of the Rayleigh-Taylor instability (RTI) process. On the contrary, the occurrence of successive EPBs is infrequent and the occurrence day of EPB remains active during equinoctial months in low solar activity years. The small growth rate of the RTI process during low solar activity years might require a strong seed perturbation to generate the EPB structure. The occurrence probability of the EPB was found to be similar during quiet and disturbed geomagnetic conditions. The results imply that the strong perturbations play an important role in the development of the EPB in low solar activity years. Nonetheless, the high growth rate of the RTI could cause the successive occurrence of the EPB in high solar activity years.

  10. Observed Parenting Practices of First-Generation Latino Families

    ERIC Educational Resources Information Center

    Domenech Rodriguez, Melanie; Davis, Melissa R.; Rodriguez, Jesus; Bates, Scott C.

    2006-01-01

    This study used an established behavioral observation methodology to examine the parenting practices of first-generation Latino parents of children 4 to 9 years of age. The study had three central aims, to examine: (1) the feasibility of using a behavioral observation methodology with Spanish-speaking immigrant families, (2) the utility of the…

  11. The Challenges, Persistence, and Success of White, Working-Class, First-Generation College Students

    ERIC Educational Resources Information Center

    Lightweis, Susan

    2014-01-01

    This essay addresses persistence and success of an underrepresented group enrolled in college who are white, working-class first-generation students. The discussion examines these college students and the challenges they face. The discussion analyzes why first-generation college students persist while others do not. Additionally, the discussion…

  12. The Challenges, Persistence, and Success of White, Working-Class, First-Generation College Students

    ERIC Educational Resources Information Center

    Lightweis, Susan

    2014-01-01

    This essay addresses persistence and success of an underrepresented group enrolled in college who are white, working-class first-generation students. The discussion examines these college students and the challenges they face. The discussion analyzes why first-generation college students persist while others do not. Additionally, the discussion…

  13. Generating Synthetic Spectra for Observing the Simulated CGM and IGM

    NASA Astrophysics Data System (ADS)

    Hummels, Cameron B.; Egan, Hilary; Peeples, Molly S.; Silvia, Devin W.; Smith, Britton D.; Turk, Matthew

    2015-01-01

    Hydrodynamical simulations can provide great insight into the behavior of many astrophysical problems. However, it can be difficult to extract the relevant quantities from these simulations for comparison against observational datasets. I will demonstrate methods for generating synthetic observations from hydrodynamical simulations using the open-source yt analysis code. Specifically, I will focus on creating realistic simulated spectra, which mimic quasar absorption line studies of the circumgalactic medium and the intergalactic medium as observed by the Cosmic Origins Spectrograph aboard HST. By producing simulated observations like those obtained with real telescopes, we can best compare theoretical models against their observational counterparts.

  14. Library design practices for success in lead generation with small molecule libraries.

    PubMed

    Goodnow, R A; Guba, W; Haap, W

    2003-11-01

    The generation of novel structures amenable to rapid and efficient lead optimization comprises an emerging strategy for success in modern drug discovery. Small molecule libraries of sufficient size and diversity to increase the chances of discovery of novel structures make the high throughput synthesis approach the method of choice for lead generation. Despite an industry trend for smaller, more focused libraries, the need to generate novel lead structures makes larger libraries a necessary strategy. For libraries of a several thousand or more members, solid phase synthesis approaches are the most suitable. While the technology and chemistry necessary for small molecule library synthesis continue to advance, success in lead generation requires rigorous consideration in the library design process to ensure the synthesis of molecules possessing the proper characteristics for subsequent lead optimization. Without proper selection of library templates and building blocks, solid phase synthesis methods often generate molecules which are too heavy, too lipophilic and too complex to be useful for lead optimization. The appropriate filtering of virtual library designs with multiple computational tools allows the generation of information-rich libraries within a drug-like molecular property space. An understanding of the hit-to-lead process provides a practical guide to molecular design characteristics. Examples of leads generated from library approaches also provide a benchmarking of successes as well as aspects for continued development of library design practices.

  15. Generation of high-titer viral preparations by concentration using successive rounds of ultracentrifugation

    PubMed Central

    2011-01-01

    Background Viral vectors provide a method of stably introducing exogenous DNA into cells that are not easily transfectable allowing for the ectopic expression or silencing of genes for therapeutic or experimental purposes. However, some cell types, in particular bone marrow cells, dendritic cells and neurons are difficult to transduce with viral vectors. Successful transduction of such cells requires preparation of highly concentrated viral stocks, which permit a high virus concentration and multiplicity of infection (MOI) during transduction. Pseudotyping with the vesicular stomatitis virus G (VSV-G) envelope protein is common practice for both lentiviral and retroviral vectors. The VSV-G glycoprotein adds physical stability to retroviral particles, allowing concentration of virus by high-speed ultracentrifugation. Here we describe a method report for concentration of virus from large volumes of culture supernatant by means of successive rounds of ultracentrifugation into the same ultracentrifuge tube. Method Stable retrovirus producer cell lines were generated and large volumes of virus-containing supernatant were produced. We then tested the transduction ability of virus following varying rounds of concentration by ultra-centrifugation. In a second series of experiments lentivirus-containing supernatant was produced by transient transfection of 297T/17 cells and again we tested the transduction ability of virus following multiple rounds of ultra-centrifugation. Results We report being able to centrifuge VSV-G coated retrovirus for as many as four rounds of ultracentrifugation while observing an additive increase in viral titer. Even after four rounds of ultracentrifugation we did not reach a plateau in viral titer relative to viral supernatant concentrated to indicate that we had reached the maximum tolerated centrifugation time, implying that it may be possible to centrifuge VSV-G coated retrovirus even further should it be necessary to achieve yet higher

  16. Radioactive waste acceptance team and generator interface yields successful implementation of waste acceptance criteria

    SciTech Connect

    Rowe, J.G.; Griffin, W.A.; Rast, D.M.

    1996-02-01

    The Fernald Environmental Management Project has developed a successful Low Level Waste Shipping Program in compliance with the Nevada Test Site Defense Waste Acceptance Criteria, Certification, and Transfer Requirements, NVO-325, Revision 1. This shipping program is responsible for the successful disposal of more than 4 million cubic feet of Low Level Waste over the past decade. The success of the Fernald Low Level Waste Shipping Program is due to the generator program staff working closely with the DOE-NV Radioactive Waste Acceptance Program Team to achieve win/win situations. The teamwork is the direct result of dedicated, proactive professionals working together toward a common objective: the safe disposition of low level radioactive waste. The growth and development of this program has many lessons learned to share with the low level waste generating community. The recognition of reciprocal interests enables consistently high annual volumes of Fernald waste disposal at the Nevada Test Site without incident. The large volumes successfully disposed serve testimony to the success of the program which is equally important to all Nevada Test Site and Fernald stakeholders. The Fernald approach to success is currently being shared with other low-level waste generators through DOE-NV sponsored outreach programs. This paper introduces examples of Fernald Environmental Restoration Management Corporation contributions to the DOE-NV Radioactive Waste Acceptance Program outreach initiatives. These practices are applicable to other low level waste disposal programs whether federal, commercial, domestic or international.

  17. A NEO population generation and observation simulation software tool

    NASA Astrophysics Data System (ADS)

    Müller, Sven; Gelhaus, Johannes; Hahn, Gerhard; Franco, Raffaella

    One of the main targets of ESA's Space Situational Awareness (SSA) program is to build a wide knowledge base about objects that can potentially harm Earth (Near-Earth Objects, NEOs). An important part of this effort is to create the Small Bodies Data Centre (SBDC) which is going to aggregate measurement data from a fully-integrated NEO observation sensor network. Until this network is developed, artificial NEO measurement data is needed in order to validate SBDC algorithms. Moreover, to establish a functioning NEO observation sensor network, it has to be determined where to place sensors, what technical requirements have to be met in order to be able to detect NEOs and which observation strategies work the best. Because of this, a sensor simulation software was needed. This paper presents a software tool which allows users to create and analyse NEO populations and to simulate and analyse population observations. It is a console program written in Fortran and comes with a Graphical User Interface (GUI) written in Java and C. The tool can be distinguished into the components ``Population Generator'' and ``Observation Simulator''. The Population Generator component is responsible for generating and analysing a NEO population. Users can choose between creating fictitious (random) and synthetic populations. The latter are based on one of two models describing the orbital and size distribution of observed NEOs: The existing socalled ``Bottke Model'' (Bottke et al. 2000, 2002) and the new ``Granvik Model'' (Granvik et al. 2014, in preparation) which has been developed in parallel to the tool. Generated populations can be analysed by defining 2D, 3D and scatter plots using various NEO attributes. As a result, the tool creates the appropiate files for the plotting tool ``gnuplot''. The tool's Observation Simulator component yields the Observation Simulation and Observation Analysis functions. Users can define sensor systems using ground- or space-based locations as well as

  18. Successive Generations in a Rat Model Respond Differently to a Constant Obesogenic Environment.

    PubMed

    Tait, Alice H; Raubenheimer, David; Green, Mark P; Cupido, Cinda L; Gluckman, Peter D; Vickers, Mark H

    2015-01-01

    Research has shown that if a mother experiences a transitory perturbation to her environment during pregnancy or lactation, there are transgenerational consequences often involving a disordered metabolic phenotype in first generation offspring with recovery across subsequent generations. In contrast, little is known about the nature of the transgenerational response of offspring when a mother experiences a perturbation that is not transitory but instead persists across generations. Our study, using a rat model, subjected the parental generation to a change in environment and concomitant shift from a grain-based to obesogenic diets to generate an adipose phenotype in first generation offspring emulating a common scenario in human urbanisation and migration. We then investigated whether the obese phenotype was stable across generations when maintained in the transitioned environment, and whether dietary macronutrient balance affected the response. We found that second and third generation offspring had a reduced body fat to lean mass ratio and a reduced appetite relative to first generation offspring, irrespective of dietary macronutrient balance. The trajectory of this response is suggestive of a reduction in chronic disease risk across generations. This is one of the first studies, to our knowledge, to investigate the transgenerational response following parental transition to a persistent obesogenic environment, and to demonstrate that successive generations respond differently to this constant environment.

  19. Successive Generations in a Rat Model Respond Differently to a Constant Obesogenic Environment

    PubMed Central

    Tait, Alice H.; Raubenheimer, David; Green, Mark P.; Cupido, Cinda L.; Gluckman, Peter D.; Vickers, Mark H.

    2015-01-01

    Research has shown that if a mother experiences a transitory perturbation to her environment during pregnancy or lactation, there are transgenerational consequences often involving a disordered metabolic phenotype in first generation offspring with recovery across subsequent generations. In contrast, little is known about the nature of the transgenerational response of offspring when a mother experiences a perturbation that is not transitory but instead persists across generations. Our study, using a rat model, subjected the parental generation to a change in environment and concomitant shift from a grain-based to obesogenic diets to generate an adipose phenotype in first generation offspring emulating a common scenario in human urbanisation and migration. We then investigated whether the obese phenotype was stable across generations when maintained in the transitioned environment, and whether dietary macronutrient balance affected the response. We found that second and third generation offspring had a reduced body fat to lean mass ratio and a reduced appetite relative to first generation offspring, irrespective of dietary macronutrient balance. The trajectory of this response is suggestive of a reduction in chronic disease risk across generations. This is one of the first studies, to our knowledge, to investigate the transgenerational response following parental transition to a persistent obesogenic environment, and to demonstrate that successive generations respond differently to this constant environment. PMID:26131906

  20. The Contribution of Family Members to First-Generation College Student Success: A Narrative Approach

    ERIC Educational Resources Information Center

    Ziemniak, Anne Elisabeth Lamkin

    2010-01-01

    Research has shown that first-generation college students are educationally disadvantaged in a number of ways. While a variety of interventions have been recommended to increase the success of this population of students in higher education, little attention has been placed on the role that families can play in supporting these students,…

  1. The Effects of Self-Efficacy on Academic Success of First-Generation College Sophomore Students

    ERIC Educational Resources Information Center

    Vuong, Mui; Brown-Welty, Sharon; Tracz, Susan

    2010-01-01

    The purpose of this study was to analyze the effects of self-efficacy on academic success of first-generation college sophomore students. The participants in the study consisted of college sophomores from 5 of the 23 California State University campuses. An online College Self-Efficacy Inventory was employed to measure participants' self-efficacy…

  2. The Effects of Self-Efficacy on Academic Success of First-Generation College Sophomore Students

    ERIC Educational Resources Information Center

    Vuong, Mui; Brown-Welty, Sharon; Tracz, Susan

    2010-01-01

    The purpose of this study was to analyze the effects of self-efficacy on academic success of first-generation college sophomore students. The participants in the study consisted of college sophomores from 5 of the 23 California State University campuses. An online College Self-Efficacy Inventory was employed to measure participants' self-efficacy…

  3. The Effects of Family Leadership Orientation on Social Entrepreneurship, Generativity and Academic Success of College Students

    ERIC Educational Resources Information Center

    Baloglu, Nuri

    2017-01-01

    In this study, the effects of family leadership orientation on social entrepreneurship, generativity and academic education success were examined with the views of college students. The study was conducted at a state university in Central Anatolia in Turkey. 402 college students who attending at three different colleges voluntarily participated in…

  4. Do Community Colleges Promote Postsecondary and Labor Market Success for First-Generation Students

    ERIC Educational Resources Information Center

    Ampaw, Frimpomaa; Partlo, Margaret; Hullender, Tammy; Wagner, Nick

    2015-01-01

    Community colleges are becoming the primary access point for a growing number of underrepresented and underserved students in the higher education system. First-generation college students make up a large proportion of this population, comprising about 45% of community college attendees (Nomi, 2005). Research has explored the transfer success of…

  5. Do Community Colleges Promote Postsecondary and Labor Market Success for First-Generation Students

    ERIC Educational Resources Information Center

    Ampaw, Frimpomaa; Partlo, Margaret; Hullender, Tammy; Wagner, Nick

    2015-01-01

    Community colleges are becoming the primary access point for a growing number of underrepresented and underserved students in the higher education system. First-generation college students make up a large proportion of this population, comprising about 45% of community college attendees (Nomi, 2005). Research has explored the transfer success of…

  6. The Contribution of Family Members to First-Generation College Student Success: A Narrative Approach

    ERIC Educational Resources Information Center

    Ziemniak, Anne Elisabeth Lamkin

    2010-01-01

    Research has shown that first-generation college students are educationally disadvantaged in a number of ways. While a variety of interventions have been recommended to increase the success of this population of students in higher education, little attention has been placed on the role that families can play in supporting these students,…

  7. Adult Learning, Generativity and "Successful" Aging in Multicultural Perspective: A Hmong American Educational Biography.

    ERIC Educational Resources Information Center

    Hones, Donald F.

    This document examines the themes of adult learning, generativity, and successful aging against the backdrop of the biography of a Hmong refugee who immigrated to the United States in 1988 at the age of 35, began studying English as a second language (ESL), and continues to study ESL in adult education classes while six of his seven children…

  8. Registering parameters and granules of wave observations: IMAGE RPI success story

    NASA Astrophysics Data System (ADS)

    Galkin, I. A.; Charisi, A.; Fung, S. F.; Benson, R. F.; Reinisch, B. W.

    2015-12-01

    Modern metadata systems strive to help scientists locate data relevant to their research and then retrieve them quickly. Success of this mission depends on the organization and completeness of metadata. Each relevant data resource has to be registered; each content has to be described; each data file has to be accessible. Ultimately, data discoverability is about the practical ability to describe data content and location. Correspondingly, data registration has a "Parameter" level, at which content is specified by listing available observed properties (parameters), and a "Granule" level, at which download links are given to data records (granules). Until recently, both parameter- and granule-level data registrations were accomplished at NASA Virtual System Observatory easily by listing provided parameters and building Granule documents with URLs to the datafile locations, usually those at NASA CDAWeb data warehouse. With the introduction of the Virtual Wave Observatory (VWO), however, the parameter/granule concept faced a scalability challenge. The wave phenomenon content is rich with descriptors of the wave generation, propagation, interaction with propagation media, and observation processes. Additionally, the wave phenomenon content varies from record to record, reflecting changes in the constituent processes, making it necessary to generate granule documents at sub-minute resolution. We will present the first success story of registering 234,178 records of IMAGE Radio Plasma Imager (RPI) plasmagram data and Level 2 derived data products in ESPAS (near-Earth Space Data Infrastructure for e-Science), using the VWO-inspired wave ontology. The granules are arranged in overlapping display and numerical data collections. Display data include (a) auto-prospected plasmagrams of potential interest, (b) interesting plasmagrams annotated by human analysts or software, and (c) spectacular plasmagrams annotated by analysts as publication-quality examples of the RPI science

  9. Health and academic success: A look at the challenges of first-generation community college students.

    PubMed

    McFadden, Deanna L H

    2016-04-01

    Community colleges in the United States serve more than six million students and are the gateway to postsecondary education for individuals from typically underserved populations such as low-income, ethnic minorities, and first-generation college students. First-generation college students are defined as students whose adoptive or natural parents' highest level of education was a high school diploma or less. Postsecondary education has the potential to reduce both health and socioeconomic disparities. First-generation community college students face significant economic, social, and cultural barriers to academic success and are the most at risk for "dropping-out." The purpose of this brief report was to explore what is known about social, psychological, and physical factors that impede first-generation community college students' academic success. Little is known about potential health and psychological barriers experienced by first-generation community college students that impact academic achievement. Advanced practice nurses (APNs) on community college campuses are in the ideal position to identify and treat health issues, and conduct much-needed research into these areas. College health centers are an important practice setting for APNs to provide direct care to students as well as influence college policies that improve student health, well-being, and promote academic success. ©2016 American Association of Nurse Practitioners.

  10. Observation of AKR generation as a self-oscillating system

    NASA Astrophysics Data System (ADS)

    Moiseenko, Irina; Mogilevsky, Mikhail

    Auroral kilometric radiation (AKR) is a powerful natural electromagnetic radio emission in the frequency range of 30 kHz to ~ 1 MHz which is generated in the near-Earth plasma and propagated from the Earth. AKR is connected with discreet auroras and its sources are situated above the auroral ionosphere, generally, in the evening and night sectors of the magnetosphere at invariant latitudes of ~ 700 , at a height of ~ 2-10 thousand kilometers, and also in the magnetospheric cusp. AKR is generated by energetic electron beams injected from the magnetotail into the auroral zone. Currently, cyclotron maser instability at the local electron gyrofrequency is considered to be a generally recognized mechanism of AKR generation. Such instability appears in the regions with low plasma density called Calvert’s cavity where plasma frequency fpe is lower than electron gyrofrequency fсe. Auroral kilometric radiation is generally observed in the frequency range of 100 - 700 kHz, and AKR spectrum width changes slowly during several dozens of minutes. We present results of the analysis of wide-band AKR structures obtained by the POLRAD experiment on board the INTERBALL-2 satellite. These structures represent a quasiperiodic sequence of splashes which more often observed at the beginning and end of AKR radiation interval. The main properties of such splashes and their possible mechanism of generation are discussed.

  11. Internal Waves in Straits (IWISE): Observations of Wave Generation

    DTIC Science & Technology

    2012-09-30

    deployment of a 2-D array of pressure-sensor-equipped inverted echo sounders (PIES) so as to observe the generation of internal waves by tidal...east of the strait to the westernmost deployments. Fig. 1 Deployment locations of Pressure sensor equipped Inverted Echo Sounders [PIES] in South...measurements of nonlinear internal waves using the inverted echo sounder , J. Atmos. Oceanic Technology, 26, 2228−2242. David M Farmer, Li, Qiang & Jae-Hun

  12. Generation of VLF saucer emissions observed by the Viking satellite

    SciTech Connect

    Loennqvist, H.; Andre, M.; Matson, L.; Bahnsen, A.; Blomberg, L.G.; Erlandson, R.E.

    1993-08-01

    The authors report observations of V shaped saucer emissions by the Viking satellite. This V shaped saucer emission refers to the observational feature of the VLF or ELF emissions which shows a v shaped appearance on a plot of frequency as a function of time. Viking provided not only wave, but electric and magnetic field measurements, as well as charged particle measurements. These measurements show electrons flowing upwards with enegies of up to a few hundred eV in conjunction with the saucer emissions. Other wave structures observed in this same region may originate from the electron flows. The satellite observations also find such events at altitudes from 4000 to 13000km, where the generation region is found to be much more spread out in space.

  13. A century of meteorological observations at Fort Valley Experimental Forest: A cooperative observer program success story

    Treesearch

    Daniel P. Huebner; Susan D. Olberding; Byron Peterson; Dino DeSimone

    2008-01-01

    Meteorological observations at Fort Valley Experimental Forest began with its establishment as early silvicultural research made heavy use of meteorological data. The Fort Valley weather data represent the longest climatological record for northern Arizona with records dating back to 1909. Importance of long-term meteorological records and access to the weather record...

  14. On the reproductive success of early-generation hatchery fish in the wild

    PubMed Central

    Christie, Mark R; Ford, Michael J; Blouin, Michael S

    2014-01-01

    Large numbers of hatchery salmon spawn in wild populations each year. Hatchery fish with multiple generations of hatchery ancestry often have heritably lower reproductive success than wild fish and may reduce the fitness of an entire population. Whether this reduced fitness also occurs for hatchery fish created with local- and predominantly wild-origin parents remains controversial. Here, we review recent studies on the reproductive success of such ‘early-generation’ hatchery fish that spawn in the wild. Combining 51 estimates from six studies on four salmon species, we found that (i) early-generation hatchery fish averaged only half the reproductive success of their wild-origin counterparts when spawning in the wild, (ii) the reduction in reproductive success was more severe for males than for females, and (iii) all species showed reduced fitness due to hatchery rearing. We review commonalities among studies that point to possible mechanisms (e.g., environmental versus genetic effects). Furthermore, we illustrate that sample sizes typical of these studies result in low statistical power to detect fitness differences unless the differences are substantial. This review demonstrates that reduced fitness of early-generation hatchery fish may be a general phenomenon. Future research should focus on determining the causes of those fitness reductions and whether they lead to long-term reductions in the fitness of wild populations. PMID:25469167

  15. Novel gratings for next-generation instruments of astronomical observations

    NASA Astrophysics Data System (ADS)

    Ebizuka, N.; Okamoto, T.; Takeda, M.; Hosobata, T.; Yamagata, Y.; Sasaki, M.; Uomoto, M.; Shimatsu, T.; Sato, S.; Hashimoto, N.; Tanaka, I.; Hattori, T.; Ozaki, S.; Aoki, W.

    2017-05-01

    We will introduce current status of development of a birefringence volume phase holographic (B-VPH) grating, volume binary (VB) grating and reflector facet transmission (RFT) grating developing as the novel dispersive optical element for astronomical instruments for the 8.2m Subaru Telescope, for next generation 30 m class huge ground-based telescopes and for next generation large space-bone telescopes. We will also introduce a hybrid grism developed for MOIRCS (Multi-Object InfraRed Camera and Spectrograph) of the Subaru Telescope and a quasi-Bragg (QB) immersion grating. Test fabrication of B-VPH gratings with a liquid crystal (LC) of UV curable and normal LCs or a resin of visible light curable are performed. We successfully fabricated VB gratings of silicon as a mold with ridges of a high aspect ratio by means of the cycle etching process, oxidation and removal of silicon oxide. The RFT grating which is a surface-relief (SR) transmission grating with sawtooth shaped ridges of an acute vertex angle. The hybrid grism, as a prototype of the RFT grating, combines a high-index prism and SR transmission grating with sawtooth shape ridges of an acute vertex angle. The mold of the SR grating for the hybrid grism on to a work of Ni-P alloy of non-electrolysic plating successfully fabricated by using our ultra-precision machine and a single-crystal diamond bite. The QB immersion grating was fabricated by a combination of an inclined QB grating, Littrow prism and surface reflection mirror.

  16. Observation of Electronic Structure Minima in High-Harmonic Generation

    SciTech Connect

    Woerner, Hans Jakob; Villeneuve, D. M.; Niikura, Hiromichi; Bertrand, Julien B.; Corkum, P. B.

    2009-03-13

    We report detailed measurements of the high-harmonic spectra generated from argon atoms. The spectra exhibit a deep minimum that is shown to be independent of the laser intensity, and is thus a clear measure of the electronic structure of the atom. We show that exact field-free continuum wave functions reproduce the minimum, but plane wave and Coulomb wave functions do not. This remarkable observation suggests that electronic structure can be accurately determined in high-harmonic experiments despite the presence of the strong laser field. Our results clarify the relation between high-harmonic generation and photoelectron spectroscopy. The use of exact continuum functions also resolves the ambiguity associated with the choice of the dispersion relation.

  17. Dust Successive Generations in Ar/SiH{sub 4} : Dust Cloud Dynamics

    SciTech Connect

    Cavarroc, M.; Mikikian, M.; Tessier, Y.; Boufendi, L.

    2008-09-07

    Silane-based plasmas are widely used to deposit nanostructured silicon thin films or to synthesize silicon nanoparticles. Dust particle formation in Ar/SiH{sub 4} plasmas is a continuous phenomenon: as long as silane precursors are provided, new dust generations are formed. Successive generations can be monitored thanks to various electrical (V{sub dc}/3H) and optical (OES, video imaging) diagnostics. Experiments presented in this paper have been performed in a capacitively-coupled radiofrequency discharge, at low pressure (12 Pa) in an Argon/Silane mixture (92:8)

  18. Successful in vitro fertilization and generation of transgenics in Black and Tan Brachyury (BTBR) mice.

    PubMed

    Baan, Mieke; Krentz, Kathleen J; Fontaine, Danielle A; Davis, Dawn Belt

    2016-12-01

    The Black and Tan Brachyury (BTBR) mouse strain is a valuable model for the study of long-term complications from obesity-induced type 2 diabetes mellitus and autism spectrum disorder. Due to technical difficulties with assisted reproduction, genetically modified animals on this background have previously been generated through extensive backcrossing, which is expensive and time-consuming. We successfully generated two separate transgenic mouse lines after direct zygote microinjection into this background strain. Additionally, we developed in vitro fertilization (IVF) methods for the BTBR mouse. We found low rates of fertilization and implantation in this strain, and identified the BTBR oocyte as the primary culprit of low success with BTBR IVF. We achieved an increase in live born pups from 5.9 to 35.6 % with IVF in the BTBR strain by use of BTBR females at a younger age (18-25 days), collection of oocytes 15-17 h after superovulation, and the use of supplemented fertilization media. This method eliminates the need for time consuming assisted embryo manipulations that are otherwise required for success with BTBR oocytes. This advancement provides an exciting opportunity to directly generate BTBR transgenics and gene-edited mice using both traditional and emerging genomic editing techniques, such as CRISPR/Cas9. These methods also allow effective colony preservation and rederivation with these strains. To our knowledge, this is the first report describing embryo manipulations in BTBR mice.

  19. UrtheCast Second-Generation Earth Observation Sensors

    NASA Astrophysics Data System (ADS)

    Beckett, K.

    2015-04-01

    UrtheCast's Second-Generation state-of-the-art Earth Observation (EO) remote sensing platform will be hosted on the NASA segment of International Space Station (ISS). This platform comprises a high-resolution dual-mode (pushbroom and video) optical camera and a dual-band (X and L) Synthetic Aperture RADAR (SAR) instrument. These new sensors will complement the firstgeneration medium-resolution pushbroom and high-definition video cameras that were mounted on the Russian segment of the ISS in early 2014. The new cameras are expected to be launched to the ISS in late 2017 via the Space Exploration Technologies Corporation Dragon spacecraft. The Canadarm will then be used to install the remote sensing platform onto a CBM (Common Berthing Mechanism) hatch on Node 3, allowing the sensor electronics to be accessible from the inside of the station, thus limiting their exposure to the space environment and allowing for future capability upgrades. The UrtheCast second-generation system will be able to take full advantage of the strengths that each of the individual sensors offers, such that the data exploitation capabilities of the combined sensors is significantly greater than from either sensor alone. This represents a truly novel platform that will lead to significant advances in many other Earth Observation applications such as environmental monitoring, energy and natural resources management, and humanitarian response, with data availability anticipated to begin after commissioning is completed in early 2018.

  20. Stressful life events, family support and successful ageing in the Biafran War generation.

    PubMed

    Chukwuorji, JohnBosco Chika; Nwoke, Mary Basil; Ebere, Magnus Okechukwu

    2017-01-01

    Although the developing countries contribute substantially to the population of the elderly, little is known about ageing in populous countries like Nigeria, particularly the Biafran War generation (BWG). Some of those who witnessed the Biafran War (also known as Nigerian Civil War) as children are well into late adulthood, while the majority of this pre-war/wartime cohort who are in their golden years will enter into later life in less than a decade from now. The aim of the present research was to examine the role of stressful life events and family support in successful ageing of the BWG. Data were collected using a self-administered survey completed by 453 members of the BWG who were ≥45 years. The survey included measures such as the Successful Ageing Inventory, Life Events Inventory, and family support subscale of Family Dynamics Scale. Hierarchical multiple regression analyses were conducted to test the hypotheses of the study. The three dimensions of stressful life events (health events, interpersonal events and work-related/financial events) had moderate negative relationships with successful ageing. Family support was moderately and positively associated with successful ageing. For the moderation hypotheses, family support was a significant moderator of only the relationship between work-related stressful life events and successful ageing, especially for the <65 years subgroup. Growing old can be a very positive experience for both the individual and the society. Family support provides social protection for older people, in the face of difficult socio-economic circumstances.

  1. Arabidopsis plants exposed to gamma radiation in two successive generations show a different oxidative stress response.

    PubMed

    van de Walle, Jorden; Horemans, Nele; Saenen, Eline; Van Hees, May; Wannijn, Jean; Nauts, Robin; van Gompel, Axel; Vangronsveld, Jaco; Vandenhove, Hildegarde; Cuypers, Ann

    2016-12-01

    When terrestrial environments get contaminated with long-lived gamma emitting radionuclides, plants that grow in these contaminated areas are exposed to gamma radiation during consecutive generations. Therefore it is important to evaluate the gamma induced stress response in plants in and between generations. The objective of this research is to reveal differences at the level of the antioxidative stress response between generations with a different radiation history. An experiment was conducted in which 7-days old Arabidopsis thaliana plants were exposed for 14 days to four different gamma dose rates: 22 mGy/h, 38 mGy/h, 86 mGy/h and 457 mGy/h. Two different plant groups were used: plants that were not exposed to gamma radiation before (P0) and plants that received the aforementioned gamma treatment during their previous generation (S1). Growth, the concentration of the antioxidants ascorbate and glutathione, a number of antioxidative enzyme activities and their gene transcript levels were analysed. A dose-rate dependent induction was seen for catalase (CAT) and guaiacol peroxidase (GPX) in the roots and for syringaldazine peroxidase (SPX) in the shoots. Differences between the two generations were observed for CAT and GPX in the roots, where a significantly higher activity of these reactive oxygen species (ROS) detoxifying enzymes was observed in the S1 generation. For SPX in the shoots, a dose dependent upregulation was observed in the P0 generation. However, high SPX activities were present for all doses in the S1 generation. These differences in enzyme activity between generations for SPX and GPX and the involvement of these enzymes in cell wall biosynthesis, suggest an important role for cell wall strengthening in the response to gamma irradiation. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. pyXSIM: Synthetic X-ray observations generator

    NASA Astrophysics Data System (ADS)

    ZuHone, John A.; Hallman, Eric. J.

    2016-08-01

    pyXSIM simulates X-ray observations from astrophysical sources. X-rays probe the high-energy universe, from hot galaxy clusters to compact objects such as neutron stars and black holes and many interesting sources in between. pyXSIM generates synthetic X-ray observations of these sources from a wide variety of models, whether from grid-based simulation codes such as FLASH (ascl:1010.082), Enzo (ascl:1010.072), and Athena (ascl:1010.014), to particle-based codes such as Gadget (ascl:0003.001) and AREPO, and even from datasets that have been created “by hand”, such as from NumPy arrays. pyXSIM can also manipulate the synthetic observations it produces in various ways and export the simulated X-ray events to other software packages to simulate the end products of specific X-ray observatories. pyXSIM is an implementation of the PHOX (ascl:1112.004) algorithm and was initially the photon_simulator analysis module in yt (ascl:1011.022); it is dependent on yt.

  3. Lymnaea glabra: progressive increase in susceptibility to Fasciola hepatica through successive generations of experimentally infected snails.

    PubMed

    Rondelaud, D; Teukeng, F F Djuikwo; Vignoles, P; Dreyfuss, G

    2015-07-01

    Experimental infections of Lymnaea glabra (two populations) with Fasciola hepatica were carried out during seven successive snail generations, to determine if prevalence and intensity of snail infection increased over time through descendants of snails already infected with F. hepatica. Controls were descendants coming from uninfected parents and infected according to the same protocol. No larval forms were found in the bodies of control snails coming from uninfected parents. In contrast, prevalence and intensity of F. hepatica infection in snails originating from infected parents progressively increased from the F2 or F3 to the F6 generation of L. glabra. In another experiment carried out with the F7 generations of L. glabra and a single generation of Galba truncatula (as controls), the prevalence of F. hepatica infection and the total number of cercariae were lower in L. glabra (without significant differences between both populations). If the number of cercariae shed by infected snails was compared to overall cercarial production noted in snails containing cercariae but dying without emission, the percentage was greater in G. truncatula (69% instead of 52-54% in L. glabra). Even if most characteristics of F. hepatica infection were lower in L. glabra, prevalence and intensity of parasite infection increased with snail generation when tested snails came from infected parents. This mode of snail infection with F. hepatica suggests an explanation for cases of fasciolosis occurring in cattle-breeding farms where paramphistomosis is lacking and G. truncatula is absent.

  4. Anomalous Seebeck coefficient observed in silicon nanowire micro thermoelectric generator

    NASA Astrophysics Data System (ADS)

    Hashimoto, S.; Asada, S.; Xu, T.; Oba, S.; Himeda, Y.; Yamato, R.; Matsukawa, T.; Matsuki, T.; Watanabe, T.

    2017-07-01

    We have found experimentally an anomalous thermoelectric characteristic of an n-type Si nanowire micro thermoelectric generator (μTEG). The μTEG is fabricated on a silicon-on-insulator wafer by electron beam lithography and dry etching, and its surface is covered with a thermally grown silicon dioxide film. The observed thermoelectric current is opposite to what is expected from the Seebeck coefficient of n-type Si. The result is understandable by considering a potential barrier in the nanowire. Upon the application of the temperature gradient across the nanowire, the potential barrier impedes the diffusion of thermally activated majority carriers into the nanowire, and it rather stimulates the injection of thermally generated minority carriers. The most plausible origin of the potential barrier is negative charges trapped at the interface between the Si nanowire and the oxide film. We practically confirmed that the normal Seebeck coefficient of the n-type Si nanowire is recovered after the hydrogen forming gas annealing. This implies that the interface traps are diminished by the hydrogen termination of bonding defects. The present results show the importance of the surface inactivation treatment of μTEGs to suppress the potential barrier and unfavorable contribution of minority carriers.

  5. GlideScope Use improves intubation success rates: an observational study using propensity score matching.

    PubMed

    Ibinson, James W; Ezaru, Catalin S; Cormican, Daniel S; Mangione, Michael P

    2014-01-01

    Rigid video laryngoscopes are popular alternatives to direct laryngoscopy for intubation, but further large scale prospective studies comparing these devices to direct laryngoscopy in routine anesthesiology practice are needed. We hypothesized that the first pass success rate with one particular video laryngoscope, the GlideScope, would be higher than the success rate with direct laryngoscopy. 3831 total intubation attempts were tracked in an observational study comparing first-pass success rate using a Macintosh or Miller-style laryngoscope with the GlideScope. Propensity scoring was then used to select 626 subjects matched between the two groups based on their morphologic traits. Comparing the GlideScope and direct laryngoscopy groups suggested that intubation would be more difficult in the GlideScope group based on the Mallampati class, cervical range of motion, mouth opening, dentition, weight, and past intubation history. Thus, a propensity score based on these factors was used to balance the groups into two 313 patient cohorts. Direct laryngoscopy was successful in 80.8% on the first-pass intubation attempt, while the GlideScope was successful in 93.6% (p <0.001; risk difference of 0.128 with a 95% CI of 0.0771 - 0.181). A greater first-attempt success rate was found when using the GlideScope versus direct laryngoscopy. In addition, the GlideScope was found to be 99% successful for intubation after initial failure of direct laryngoscopy, helping to reduce the incidence of failed intubation.

  6. Nest guarding from observation blinds: strategy for improving Puerto Rican parrot nest success

    USGS Publications Warehouse

    Lindsey, G.D.

    1992-01-01

    The effectiveness of 17 yr of nestguarding from observation blinds for increasing reproductive success of the endangered Puerto Rican Parrot (Amazona vittata) is described. As personnel and time allowed, active nests were guarded part-time during the nest site exploration and selection s stage of the breeding cycle, and part-time to full-time when a nest contained eggs or chicks. Biologists identified nine categories of threat to the success of parrot nests. Since 1973, a minimum of 20 nests, which otherwise would have failed, successfully produced fledglings as a direct result of nest guarding and intervention. Nest success averaged 66% with nest guarding compared to an estimated 38% without guarding. Nest guarding from blinds can help maintain a wild population of a critically endangered species while other management techniques are being developed to stimulate population growth.

  7. Magnetism in galaxies - Observational overview and next generation radio telescopes

    NASA Astrophysics Data System (ADS)

    Beck, Rainer

    2011-06-01

    The strength and structure of cosmic magnetic fields is best studied by observations of radio continuum emission, its polarization and its Faraday rotation. Fields with a well-ordered spiral structure exist in many types of galaxies. Total field strengths in spiral arms and bars are 20-30 μG and dynamically important. Strong fields in central regions can drive gas inflows towards an active nucleus. The strongest regular fields (10-15 μG) are found in interarm regions, sometimes forming ``magnetic spiral arms'' between the optical arms. The typical degree of polarization is a few % in spiral arms, but high (up to 50%) in interarm regions. The detailed field structures suggest interaction with gas flows. Faraday rotation measures of the polarization vectors reveals large-scale patterns in several spiral galaxies which are regarded as signatures of large-scale (coherent) fields generated by dynamos. - Polarization observations with the forthcoming large radio telescopes will open a new era in the observation of magnetic fields and should help to understand their origin. Low-frequency radio synchrotron emission traces low-energy cosmic ray electrons which can propagate further away from their origin. LOFAR (30-240 MHz) will allow us to map the structure of weak magnetic fields in the outer regions and halos of galaxies, in galaxy clusters and in the Milky Way. Polarization at higher frequencies (1-10 GHz), to be observed with the EVLA, MeerKAT, APERTIF and the SKA, will trace magnetic fields in the disks and central regions of galaxies in unprecedented detail. All-sky surveys of Faraday rotation measures towards a dense grid of polarized background sources with ASKAP and the SKA are dedicated to measure magnetic fields in distant intervening galaxies and clusters, and will be used to model the overall structure and strength of the magnetic field in the Milky Way.

  8. The computer-generated treatment plan... Create the nucleus to successful systems.

    PubMed

    Bernhardt, Christene

    2004-12-01

    A well-managed, highly efficient practice relies on the comprehensive information provided through effective treatment planning. Computer-generated treatment plans are successful only if the 14 key points of information are included within the plan. Major systems such as scheduling, financial agreements, and insurance processing fail if adequate information is not provided through the treatment plan. Successful interactions with patients at the time of the consultation rely heavily on having adequate information at your fingertips. The treatment plan is truly the foundation to all communications that must occur during the patient's experience, and ensures that every team member has clear and easy access to the status of each patient as treatment unfolds.

  9. Success and Failure in Helping SMEs. A Three-Year Observational Study.

    ERIC Educational Resources Information Center

    Stewardson, Dave; Coleman, Shirley

    2003-01-01

    A 3-year observational study of a project to help small and medium-sized enterprises (SMEs) conducted by a British university highlighted initial contacts and working methods that were effective. Results identified why some SMEs do not make full use of facilities offered and reasons for overall success. (Contains 13 references.) (JOW)

  10. Observations of HF backscatter decay rates from HAARP generated FAI

    NASA Astrophysics Data System (ADS)

    Bristow, William; Hysell, David

    2016-07-01

    Suitable experiments at the High-frequency Active Auroral Research Program (HAARP) facilities in Gakona, Alaska, create a region of ionospheric Field-Aligned Irregularities (FAI) that produces strong radar backscatter observed by the SuperDARN radar on Kodiak Island, Alaska. Creation of FAI in HF ionospheric modification experiments has been studied by a number of authors who have developed a rich theoretical background. The decay of the irregularities, however, has not been so widely studied yet it has the potential for providing estimates of the parameters of natural irregularity diffusion, which are difficult measure by other means. Hysell, et al. [1996] demonstrated using the decay of radar scatter above the Sura heating facility to estimate irregularity diffusion. A large database of radar backscatter from HAARP generated FAI has been collected over the years. Experiments often cycled the heater power on and off in a way that allowed estimates of the FAI decay rate. The database has been examined to extract decay time estimates and diffusion rates over a range of ionospheric conditions. This presentation will summarize the database and the estimated diffusion rates, and will discuss the potential for targeted experiments for aeronomy measurements. Hysell, D. L., M. C. Kelley, Y. M. Yampolski, V. S. Beley, A. V. Koloskov, P. V. Ponomarenko, and O. F. Tyrnov, HF radar observations of decaying artificial field aligned irregularities, J. Geophys. Res. , 101, 26,981, 1996.

  11. Observations of HF backscatter decay rates from HAARP generated FAI

    NASA Astrophysics Data System (ADS)

    Bristow, W. A.; Hysell, D. L.

    2016-12-01

    Suitable experiments at the High-frequency Active Auroral Research Program (HAARP) facilities in Gakona, Alaska, create a region of ionospheric Field-Aligned Irregularities (FAI) that produces strong radar backscatter observed by the SuperDARN radar on Kodiak Island, Alaska. Creation of FAI in HF ionospheric modification experiments has been studied by a number of authors who have developed a rich theoretical background. The decay of the irregularities, however, has not been so widely studied yet it has the potential for providing estimates of the parameters of natural irregularity diffusion, which are difficult measure by other means. Hysell, et al. [1996] demonstrated using the decay of radar scatter above the Sura heating facility to estimate irregularity diffusion. A large database of radar backscatter from HAARP generated FAI has been collected over the years. Experiments often cycled the heater power on and off in a way that allowed estimates of the FAI decay rate. The database has been examined to extract decay time estimates and diffusion rates over a range of ionospheric conditions. This presentation will summarize the database and the estimated diffusion rates, and will discuss the potential for targeted experiments for aeronomy measurements. Hysell, D. L., M. C. Kelley, Y. M. Yampolski, V. S. Beley, A. V. Koloskov, P. V. Ponomarenko, and O. F. Tyrnov, HF radar observations of decaying artificial field aligned irregularities, J. Geophys. Res. , 101, 26,981, 1996.

  12. The Goodrich 3rd generation DB-110 system: successful flight test on the F-16 aircraft

    NASA Astrophysics Data System (ADS)

    Lange, Davis; Iyengar, Mrinal; Maver, Larry; Dyer, Gavin; Francis, John

    2007-04-01

    The 3rd Generation Goodrich DB-110 system provides users with a three (3) field-of-view high performance Airborne Reconnaissance capability that incorporates a dual-band day and nighttime imaging sensor, a real time recording and a real time data transmission capability to support long range, medium range, and short range standoff and over-flight mission scenarios, all within a single pod. Goodrich developed their 3rd Generation Airborne Reconnaissance Pod for operation on a range of aircraft types including F-16, F-15, F-18, Euro-fighter and older aircraft such as the F-4, F-111, Mirage and Tornado. This system upgrades the existing, operationally proven, 2nd generation DB-110 design with enhancements in sensor resolution, flight envelope and other performance improvements. Goodrich recently flight tested their 3rd Generation Reconnaissance System on a Block 52 F-16 aircraft with first flight success and excellent results. This paper presents key highlights of the system and presents imaging results from flight test.

  13. Environmental Stewardship at the Savannah River Site: Generations of Success - 13212

    SciTech Connect

    Looney, Brian B.; Bergren, Christopher L.; Gaughan, Thomas F.; Aylward, Robert S.; Guevara, Karen C.; Whitaker, Wade C.; Hennessey, Brian T.; Mills, Gary L.; Blake, John I.

    2013-07-01

    Approximately sixty years ago, the Savannah River Site (SRS) was built to produce nuclear materials. SRS production operations impacted air, soil, groundwater, ecology, and the local environment. Throughout its history, SRS has addressed these contamination issues directly and has maintained a commitment to environmental stewardship. The Site boasts many environmental firsts. Notably, SRS was the first major Department of Energy (DOE) facility to perform a baseline ecological assessment. This pioneering effort, by Ruth Patrick and the Philadelphia Academy of Sciences, was performed during SRS planning and construction in the early 1950's. This unique early generation of work set the stage for subsequent efforts. Since that time, the scientists and engineers at SRS pro-actively identified environmental problems and developed and implemented effective and efficient environmental management and remediation solutions. This second generation, spanning the 1980's through the 2000's, is exemplified by numerous large and small cleanup actions to address metals and radionuclides, solvents and hydrocarbons, facility and area decommissioning, and ecological restoration. Recently, a third generation of environmental management was initiated as part of Enterprise SRS. This initiative to 'Develop and Deploy Next Generation Cleanup Technologies' formalizes and organizes the major technology matching, development, and implementation processes associated with historical SRS cleanup success as a resource to support future environmental management missions throughout DOE. The four elements of the current, third generation, effort relate to: 1) transition from active to passive cleanup, 2) in situ decommissioning of large nuclear facilities, 3) new long term monitoring paradigms, and 4) a major case study related to support for recovery and restoration of the Japanese Fukushima-Daiichi nuclear power plant and surrounding environment. (authors)

  14. Application of electrolytically generated iodine(I) to the successive determination of halides

    SciTech Connect

    Kostromin, A.I.; Vagizova, A.S.; Badretdinova, G.Z.; Abdullin, I.F.

    1986-06-10

    Conditions have been studied for the electrolytic generation of iodine(I) at a platinum electrode from RI solutions (where R is CH/sub 3/, C/sub 2/H/sub 5/, C/sub 3/H/sub 7/, C/sub 4/H/sub 9/) in a support electrolyte of 0.2 M HCkO/sub 4/ in glacial CH/sub 3/COOH. At potentials from 1.8 to 2.3 V (relative to a Ag/AgCl electrode), RI is oxidized to iodine(I) in quantitative yield with respect to current. The actual redox potentials of the I(I)/RI systems were measured. A procedure was developed for the successive coulometric titration of halide ions in a mixture.

  15. Navigating New Worlds: A Real-Time Look at How Successful and Non-Successful First-Generation College Students Negotiate Their First Semesters

    ERIC Educational Resources Information Center

    Morales, Erik E.

    2012-01-01

    This study of fifteen first generation American college freshmen documents their initial semester with a focus on factors and dispositions contributing to eventual success or failure. Students were identified prior to campus arrival, allowing for immediate and real-time data collection as they were experiencing the beginning of their college…

  16. Observing preschoolers' social-emotional behavior: structure, foundations, and prediction of early school success.

    PubMed

    Denham, Susanne A; Bassett, Hideko Hamada; Thayer, Sara K; Mincic, Melissa S; Sirotkin, Yana S; Zinsser, Katherine

    2012-01-01

    Social-emotional behavior of 352 3- and 4-year-olds attending private child-care and Head Start programs was observed using the Minnesota Preschool Affect Checklist, Revised (MPAC-R). Goals of the investigation included (a) using MPAC-R data to extract a shortened version, MPAC-R/S, comparing structure, internal consistency, test-retest reliability, and stability of both versions; and, using the shortened measure, to examine (b) age, gender, and risk status differences in social-emotional behaviors; (c) contributions of emotion knowledge and executive function to social-emotional behaviors; and (d) contributions of social-emotional behaviors to early school adjustment and kindergarten academic success. Results show that reliability of MPAC-R/S was as good, or better, than the MPAC-R. MPAC-R/S structure, at both times of observation, included emotionally negative/aggressive, emotionally regulated/prosocial, and emotionally positive/productive behaviors; MPAC-R structure was similar but less replicable over time. Age, gender, and risk differences were found. Children's emotion knowledge contributed to later emotionally regulated/prosocial behavior. Finally, preschool emotionally negative/aggressive behaviors were associated with concurrent and kindergarten school success, and there was evidence of social-emotional behavior mediating relations between emotion knowledge or executive function, and school outcomes. The importance of portable, empirically supported observation measures of social-emotional behaviors is discussed along with possible applications, teacher utilization, and implementation barriers.

  17. The Academic Success of First-Generation African American Male College Students Attending Predominantly White Institutions of Higher Education

    ERIC Educational Resources Information Center

    Hewing, Venus

    2011-01-01

    A quantitative, correlational design was utilized in this study to examine the relationship between academic self-efficacy, racial identity, and the academic success of first-generation African American male college students at Predominantly White Institutions of higher education. The study comprised 89 first-generation African American male…

  18. The Academic Success of First-Generation African American Male College Students Attending Predominantly White Institutions of Higher Education

    ERIC Educational Resources Information Center

    Hewing, Venus

    2011-01-01

    A quantitative, correlational design was utilized in this study to examine the relationship between academic self-efficacy, racial identity, and the academic success of first-generation African American male college students at Predominantly White Institutions of higher education. The study comprised 89 first-generation African American male…

  19. Observed Methods for Generating Analogies in Scientific Problem Solving. Revised.

    ERIC Educational Resources Information Center

    Clement, John

    Evidence from video tapes of experts thinking aloud and using analogies in scientific problem solving is presented. Four processes appear to be important in using an analogy: (1) generating the analogy; (2) establishing confidence in the validity of the analogy relation; (3) understanding the analogous case; and (4) applying findings to the…

  20. Observations on quality senior health business: success patterns and policy implications.

    PubMed

    Yang, Ya-Ting; Hsu, Yi-Hsin Elsa; Chen, Ya-Mei; Su, Shyi; Chang, Yao-Mao; Iqbal, Usman; Yujiro, Handa; Lin, Neng-Pai

    2016-04-01

    Population ageing is a global issue that affects almost every country. Most ageing researches focused on demand side and studies related to supply side were relatively scarce. This study selected quality enterprises focus on ageing health and analysed their patterns on providing quality services successfully. Our study selected quality senior health enterprises and explored their success patterns through face-to-face semi-structured in-depth interviews with CEO of each enterprise in 2013. Thirty-three quality senior health enterprises in Taiwan. Thirty-three CEO's of enterprises were interviewed individually. None. Core values and vision, historical development, organization structure, services/products provided, delivering channels, customer relationships and further development strategies. Our results indicated success patterns for senior enterprises that there were meeting diversified lifestyles and substitutive needs for the elderly and their caregivers, providing a total solution for actual/virtual integration and flexible one-stop shopping services. We classified these enterprises by used degree of clicks-and-mortar of services and residing situation of the elderly. Industry characteristics and policy implications were summarized. Our observations will serve as a primary evidenced base for enterprises developing their senior market, and also for opening dialogue between customers and enterprises to facilitate valuable opportunities for co-creation between the supply and demand sides. © The Author 2016. Published by Oxford University Press in association with the International Society for Quality in Health Care; all rights reserved.

  1. Accuracy evaluation of the next-generation geodetic VLBI systems from first observations

    NASA Astrophysics Data System (ADS)

    Elosegui, P.; Ruszczyk, C. A.; Niell, A. E.; Rajagopalan, G.

    2016-12-01

    The rollout of the next-generation VLBI network has begun with the deployment in February 2016 of a new VLBI antenna at the Kokee Park Geophysical Observatory (KPGO), Hawaii, a joint effort of the NASA Goddard Space Flight Center, the United States Naval Observatory, and MIT Haystack Observatory. The new VLBI systems (a.k.a. the VLBI Global Observing System, or VGOS) are a key component for achieving the accuracy goals of the Global Geodetic Observing System (GGOS). Some salient observational features of VGOS, such as broadband (2-14 GHz) feeds, dual-polarization receivers, wideband digital backends, and fast-slewing small (12-13 m) antennas, address the need for improved geodetic accuracy by decreasing the observable noise while increasing sampling of the atmosphere. The VGOS system at KPGO joins the successful VGOS prototype systems at the Goddard Geophysical and Astronomical Observatory (GGAO), Maryland, and at Westford, Massachusetts, which have been making VGOS geodetic observations since December 2014. We will present preliminary geodetic results and an accuracy evaluation from these early VGOS observing sessions.

  2. Observation of successive TGFs produced by the same thunderstorm systems throughout their lifetime

    NASA Astrophysics Data System (ADS)

    Ursi, Alessandro; Marisaldi, Martino; Tavani, Marco; Argan, Andrea; Dietrich, Stefano; Casella, Daniele; Sanò, Paolo

    2016-04-01

    Since their discovery in early 1990s, Terrestrial Gamma-ray Flashes (TGFs) exhibited a clear correlation with thunderstorm activity. The elusive nature of these events and the strong absorption of gamma-rays in the lowest layers of the atmosphere dramatically limits our observation of this phenomenon: the few missions currently detecting TGFs are probably revealing just the tip of the iceberg of a much wider population. Theoretical models, radar measurements and cross-correlations with radio waves emitted by lightning strokes suggest every storm could, in principle, produce a large number of gamma flashes throughout its entire lifetime: however, observation of more TGFs from the same thunderstorm system, even after several hours, is difficult to perform, because successive passes on the same latitude region by high-inclination orbit satellites are shifted westward by ~25°. In this perspective, the AGILE mission has a privileged role, thanks to its unique quasi equatorial (2.5° inclination) orbit, that allows for the follow-up of the same geographic region on the equator at each orbital passage. In more than 8 years activity, we identify tens of cases of more TGFs coming from the same thunderstorm system, either during the same passage, or in the successive passages. We take advantage of data acquired by meteorological satellites to characterize the meteorological scenario associated to these events.

  3. Vandhalla - A Sport Centre and a Successful Example of First-Generation Universal Design.

    PubMed

    Grangaard, Sidse; Ryhl, Camilla

    2016-01-01

    The research project 'Evaluation of Vandhalla' is a study of the perceived quality of the new building as well as the design competition and design process leading to the final design. The evaluation focuses on the mindset of the winning entry, the design process, the design solution and the value of Vandhalla. Vandhalla is a sport centre including an indoor swimming pool at the Danish folk high school, Egmont. Empirically, the evaluation is based on qualitative interviews and walkthroughs on site with the architects, the client, personnel and students. The evaluation shows that Vandhalla is a successful example of an inclusive building in Denmark. The paper points at two factors having an impact on the result: the client as a key driver and the understanding of the users. The general use of knowledge as well as the winning design team's use of knowledge in the work with the design is problematized. It is suggested that Vandhalla should be regarded as a contribution to the first generation of Universal Design (UD) in Denmark. The Evaluation was conducted by the authors at SBi Aalborg University and financed by Realdania.

  4. How Does Measuring Generate Evidence? The Problem of Observational Grounding

    NASA Astrophysics Data System (ADS)

    Tal, Eran

    2016-11-01

    The epistemology of measurement is an area of philosophy that studies the relationships between measurement and knowledge. One of its central aims is to explain how measurement can function as a reliable source of scientific evidence. Key to such explanation is a clear characterization of the dependence of measurement on observation, but such characterization has remained elusive. This article traces the recent historical trajectory of views on the observational grounding of measurement, clarifies the current state of the problem, and proposes new directions for progress. Specifically, I argue in favour of viewing measurement outcomes as the best predictors of observed instrument indications under a given theoretical-statistical model of the measurement process. The evidential efficacy of measurement outcomes is explained by their relatively high epistemic security, rather than by their inferential or structural closeness to observation.

  5. Ostreid herpesvirus 1 (OsHV-1) detection among three successive generations of Pacific oysters (Crassostrea gigas).

    PubMed

    Barbosa-Solomieu, V; Dégremont, L; Vázquez-Juárez, R; Ascencio-Valle, F; Boudry, P; Renault, T

    2005-01-01

    Ostreid Herpesvirus 1 (OsHV-1) was likely detected in Pacific oysters, Crassostrea gigas, at different stages of development. Viral infections were associated with high mortality rates in the spat and larvae. Furthermore, the persistance of OsHV-1 in asymptomatic adults was demonstrated by detection of viral DNA and proteins. In the present study, three successive generations of C. gigas (G0 and G1 parental oysters, G1 and G2 larvae) were screened for OsHV-1 by PCR. Viral DNA was detected in 2-day-old larvae, indicating that infection may take place at very early stages. Although results strengthen the hypothesis of a vertical transmission, it was not possible to predict the issue of a particular type of cross. Indeed, the detection of viral DNA in parental oysters did not systematically correspond to a productive infection or result in a successful transmission to the progeny. However, the infective status of the parents appeared to have an influence on both the infection and the survival rates of the progeny. Crosses involving an OsHV-1 infected male and a non-infected female resulted in hatching and larval survival rates statistically lower than those observed in the other types of cross. These results suggest that OsHV-1-infected females may transmit to their offspring some kind of protection or resistance against viral infection.

  6. The Observational Consequences of Proton-Generated Waves at Shocks

    NASA Technical Reports Server (NTRS)

    Reames, Donald V.

    2000-01-01

    In the largest solar energetic particle (SEP) events, acceleration takes place at shock waves driven out from the Sun by fast coronal mass ejections. Protons streaming away from strong shocks generate Alfven waves that trap particles in the acceleration region, limiting outflowing intensities but increasing the efficiency of acceleration to higher energies. Early in the events, with the shock still near the Sun, intensities at 1 AU are bounded and spectra are flattened at low energies. Elements with different charge-to-mass ratios, Q/A, differentially probe the wave spectra near shocks, producing abundance ratios that vary in space and time. An initial rise in He/H, while Fe/O declines, is a typical symptom of the non-Kolmogorov wave spectra in the largest events. Strong wave generation can cause cross-field scattering near the shock and unusually rapid reduction in anisotropies even far from the shock. At the highest energies, shock spectra steepen to form a "knee." For protons, this spectral knee can vary from approx. 10 MeV to approx. 1 GeV depending on shock conditions for wave growth. In one case, the location of the knee scales approximately as Q/A in the energy/nucleon spectra of other species.

  7. Idea Generation in Student Writing: Computational Assessments and Links to Successful Writing

    ERIC Educational Resources Information Center

    Crossley, Scott A.; Muldner, Kasia; McNamara, Danielle S.

    2016-01-01

    Idea generation is an important component of most major theories of writing. However, few studies have linked idea generation in writing samples to assessments of writing quality or examined links between linguistic features in a text and idea generation. This study uses human ratings of idea generation, such as "idea fluency, idea…

  8. Idea Generation in Student Writing: Computational Assessments and Links to Successful Writing

    ERIC Educational Resources Information Center

    Crossley, Scott A.; Muldner, Kasia; McNamara, Danielle S.

    2016-01-01

    Idea generation is an important component of most major theories of writing. However, few studies have linked idea generation in writing samples to assessments of writing quality or examined links between linguistic features in a text and idea generation. This study uses human ratings of idea generation, such as "idea fluency, idea…

  9. Effect of Adhesive Application on Sealant Success: A Clinical Study of Fifth and Seventh Generation Adhesive Systems.

    PubMed

    Tandon, Vaibhav; Lingesha, Ravishanakar Telgi; Tangade, Pradeep Shankar; Tirth, Amit; Pal, Sumit Kumar; Lingesha, Chaitra Telgi; Arora, Vikram; Yadav, Vipul

    2015-10-01

    The aim of the study was to compare the effect of fifth and seventh generation bonding agent on sealant success. Sixty-four school children aged six to nine years received sealants in four permanent molars in a split mouth design, such that each patient received sealant in the first permanent molar with fifth generation bonding agent in one arch and seventh generation bonding agent in the other arch; contra-lateral molars were sealed with sealant alone. The evaluation was carried out at baseline, three months, six months and 12 months, according to the criteria by Feigal et al, in 2000. Chi- square test was used to analyze data at P<0.05 level of significance. Statistically significant differences were found for sealant retention between fifth generation and sealant group, and fifth generation and seventh generation groups; whereas, no significant difference was found for sealant retention between seventh generation and sealant group at three, six and 12 months. As separate etch and rinse steps are not required for seventh generation bonding agents, and almost similar results were obtained for both sealant and seventh generation groups, it can be concluded that application of sealant along with a seventh generation bonding agent may enhance sealant success and can be used for caries prevention in preventive programs.

  10. Effect of Adhesive Application on Sealant Success: A Clinical Study of Fifth and Seventh Generation Adhesive Systems

    PubMed Central

    Tandon, Vaibhav; Tangade, Pradeep Shankar; Tirth, Amit; Pal, Sumit Kumar; Lingesha, Chaitra Telgi; Arora, Vikram; Yadav, Vipul

    2015-01-01

    Objectives: The aim of the study was to compare the effect of fifth and seventh generation bonding agent on sealant success. Materials and Methods: Sixty-four school children aged six to nine years received sealants in four permanent molars in a split mouth design, such that each patient received sealant in the first permanent molar with fifth generation bonding agent in one arch and seventh generation bonding agent in the other arch; contra-lateral molars were sealed with sealant alone. The evaluation was carried out at baseline, three months, six months and 12 months, according to the criteria by Feigal et al, in 2000. Chi- square test was used to analyze data at P<0.05 level of significance. Results: Statistically significant differences were found for sealant retention between fifth generation and sealant group, and fifth generation and seventh generation groups; whereas, no significant difference was found for sealant retention between seventh generation and sealant group at three, six and 12 months. Conclusion: As separate etch and rinse steps are not required for seventh generation bonding agents, and almost similar results were obtained for both sealant and seventh generation groups, it can be concluded that application of sealant along with a seventh generation bonding agent may enhance sealant success and can be used for caries prevention in preventive programs. PMID:27252754

  11. Observation of broadband terahertz wave generation from liquid water

    NASA Astrophysics Data System (ADS)

    Jin, Qi; E, Yiwen; Williams, Kaia; Dai, Jianming; Zhang, X.-C.

    2017-08-01

    Bulk liquid water is a strong absorber in the terahertz (THz) frequency range, due to which liquid water has historically been sworn off as a source for THz radiation. Here, we experimentally demonstrate the generation of broadband THz waves from liquid water excited by femtosecond laser pulses. Our measurements reveal the critical dependence of the THz field upon the relative position between the water film and the focal point of the laser beam. The THz radiation from liquid water shows distinct characteristics when compared with the THz radiation from air plasmas with single color optical excitation. First, the THz field is maximized with the laser beam of longer pulse durations. In addition, the p-polarized component of the emitted THz waves will be influenced by the polarization of the optical excitation beam. It is also shown that the energy of the THz radiation is linearly dependent on the excitation pulse energy.

  12. Success Rate of MTA Pulpotomy on Vital Pulp of Primary Molars: A 3-Year Observational Study

    PubMed Central

    Tyagi, Rishi

    2016-01-01

    Introduction Vital pulp therapy is a major contributor in the preservation of primary dentition after caries affliction. Introduction of mineral trioxide aggregate (MTA) has revolutionized such treatment. Aim The aim of our study was to evaluate and correlate the effects of MTA clinically and radiographically on pulpotomized primary molars till their exfoliation or extraction followed by histological evaluation. Study design This is an observational study. Materials and methods A total of 25 teeth were selected from 5- to 8-year-old children requiring pulp therapy on the basis of inclusion and exclusion criterion. The teeth were treated by conventional pulpotomy technique under aseptic conditions using MTA and were immediately restored with stainless steel crown. The teeth were assessed postoperatively till 36 months. The exfoliated or extracted teeth were examined histologically. Results The pulpotomized teeth were vital with no adverse clinical findings during the observation period. After 3 months, one tooth showed internal resorption, but the same was not observed after 12 months. Pulp canal obliteration was seen in three cases. At the end of the study, five teeth were exfoliated and one tooth was extracted for maintaining arch symmetry. The histological examination of extracted tooth revealed the presence of healthy pulp and the area of true calcification. Remaining exfoliated teeth presented dentin bridge formation. Statistics Frequencies and percentages were used for descriptive statistics. Fisher’s exact tests were used to see the difference between clinical and radiological findings. The probability value was fixed at 5% level of significance. Conclusion The response of pulp in primary teeth to MTA was favorable in all cases from clinical and radiographic perspective, and histological evaluation confirmed the observation. How to cite this article Godhi B, Tyagi R. Success Rate of MTA Pulpotomy on Vital Pulp of Primary Molars: A 3-Year Observational Study

  13. Establishing the next generation at work: leader generativity as a moderator of the relationships between leader age, leader-member exchange, and leadership success.

    PubMed

    Zacher, Hannes; Rosing, Kathrin; Henning, Thomas; Frese, Michael

    2011-03-01

    In this study, the authors investigated leader generativity as a moderator of the relationships between leader age, leader-member exchange, and three criteria of leadership success (follower perceptions of leader effectiveness, follower satisfaction with leader, and follower extra effort). Data came from 128 university professors paired with one research assistant each. Results showed positive relationships between leader age and leader generativity, and negative relationships between leader age and follower perceptions of leader effectiveness and follower extra effort. Consistent with expectations based on leadership categorization theory, leader generativity moderated the relationships between leader age and all three criteria of leadership success, such that leaders high in generativity were better able to maintain high levels of leadership success at higher ages than leaders low in generativity. Finally, results of mediated moderation analyses showed that leader-member exchange quality mediated these moderating effects. The findings suggest that, in combination, leader age and the age-related construct of generativity importantly influence leadership processes and outcomes.

  14. Observation of spontaneous polarization misalignments in periodically poled crystals using second-harmonic generation microscopy.

    PubMed

    Tzeng, Yu-Yi; Zhuo, Zong-Yan; Lee, Ming-Yin; Liao, Chien-Sheng; Wu, Pei-Chun; Huang, Chin-Jie; Chan, Ming-Che; Liu, Tzu-Ming; Lin, Yen-Yin; Chu, Shi-Wei

    2011-06-06

    Periodically poled crystal (PPC) is a key component for nonlinear optical applications. Its poling quality relies largely on successful domain inversion and the alignment of spontaneous polarization (SP) vectors in each domain. Here we report the unexpected observation of bulk second harmonic generation (SHG) in PPC when excitation propagating along its optical axis. Based on its tensorial nature, SHG is highly sensitive to the orientation of SP, and therefore the misalignment of SP in each domain of PPC can be revealed noninvasively by SHG microscopy. This nonlinear imaging modality provides optical sectioning capability with 3D sub-micrometer resolution, so it will be useful for in situ investigation of poling quality in PPC.

  15. New generation lidar systems for eye safe full time observations

    NASA Technical Reports Server (NTRS)

    Spinhirne, James D.

    1995-01-01

    The traditional lidar over the last thirty years has typically been a big pulse low repetition rate system. Pulse energies are in the 0.1 to 1.0 J range and repetition rates from 0.1 to 10 Hz. While such systems have proven to be good research tools, they have a number of limitations that prevent them from moving beyond lidar research to operational, application oriented instruments. These problems include a lack of eye safety, very low efficiency, poor reliability, lack of ruggedness and high development and operating costs. Recent advances in solid state laser, detectors and data systems have enabled the development of a new generation of lidar technology that meets the need for routine, application oriented instruments. In this paper the new approaches to operational lidar systems will be discussed. Micro pulse lidar (MPL) systems are currently in use, and their technology is highlighted. The basis and current development of continuous wave (CW) lidar and potential of other technical approaches is presented.

  16. Noaa's Jpss Program: the Next Generation of Operational Earth Observations

    NASA Astrophysics Data System (ADS)

    Goldberg, M.

    2012-12-01

    The Joint Polar Satellite System is NOAA's new operational satellite program and includes the SUOMI National Polar-orbiting Partnership (NPP) as a bridge between NOAA's operational Polar Orbiting Environmental Satellite (POES) series, which began in 1978, and the first JPSS operational satellite scheduled for launch in 2017. The NPP was completed as originally planned and launched on October 28, 2011 and carries the following five sensors: - Visible/Infrared Imager Radiometer Suite (VIIRS) that provides advanced imaging and radiometric capabilities. - Cross-track Infrared Sounder (CrIS) that provides improved atmospheric moisture and temperature profiles in clear conditions. - Advanced Technology Microwave Sounder (ATMS) that provides improved atmospheric moisture and temperature profiles in cloudy conditions. - Ozone Mapping and Profiler Suite (OMPS) that provides improved vertical and horizontal measurements of the distribution of ozone in the Earth's atmosphere. - Clouds and the Earth's Radiant Energy System (CERES) sensor that continues precise, calibrated global measurements of the earth's radiation budget JPSS provides critical data for key NOAA product and services, which the Nation depends on. These products and services include: Weather forecasting - data from the CRIS and the ATMS are needed to forecast weather events out to 7 days. Nearly 85% of all data used in weather forecasting are from polar orbiting satellites. Environmental monitoring - data from the VIIRS are used to monitor the environment including the health of coastal ecosystems, drought conditions, hydrology, fire, smoke, dust, snow and ice, and the state of oceans, including sea surface temperature and ocean color. Climate monitoring - data from JPSS instruments, including OMPS, CERES and TSIS will provide continuity to climate data records established using NOAA POES and NASA Earth Observing System (EOS) satellite observations. These data records provide a unified and coherent long

  17. Experimental Observation of RF Radiation Generated by an Explosively Driven Voltage Generator

    DTIC Science & Technology

    2005-08-15

    generation systems at Loki Inc. located in Rolla, Missouri. A pulse-forming network and transmitting antenna were constructed and attached to the voltage...INTRODUCTION In April 2005, several pulsed-power experiments were performed using explosively driven voltage generation systems at Loki Inc. located...Offi ce of Naval Research sponsored NRL’s participation. During the experiments, Loki Inc. was persuaded, with the permission of Dr. Altgilbers, to

  18. Spacecraft Trajectory Generation by Successive Approximation for Powered Descent and Cyclers

    NASA Astrophysics Data System (ADS)

    Casoliva, Jordi

    Methods for spacecraft trajectory generation must be reliable. Complex nonlinear dynamics and constraints impede straightforward approaches. The approach pursued in this dissertation is to use successive approximation, which entails solving a sequence of problems, each one of which can be solved reliably, leading to the solution of the problem of interest. First, contractive sequential convex programming (CSCP) is developed and then applied to the problem of optimal powered descent landing in the presence of complex constraints, aerodynamic force and nonlinear engine performance. Second, numerical continuation is applied to the generation of cycler (periodic) spacecraft trajectories in the Earth-Moon system, the challenge here being the multiple scales of the three-body dynamics. The first-order necessary conditions for minimum-fuel powered descent are derived and interpreted. Both a point-mass model with throttle and thrust angle control and a rigid-body model with throttle and angular velocity control are considered, with a more complete analysis of the rigid-body case than previously available in the literature. The effects of boundary conditions on the thrust direction and finite bounds on the angular velocities are analyzed for the rigid-body case. Minimum-fuel solutions, obtained numerically, illustrate the optimal strategies. The optimal powered descent landing problem considered in the development of CSCP has a convex cost function, nonlinear dynamics, convex state constraints and nonlinear non-convex control constraints. The non-convexity in the control constraints is handled with the lossless convexification technique which consists of a convex relaxation on the control constraints. The novelty of CSCP is the ability to account for nonlinear dynamics and nonlinear control bounds in the optimal control problem and the use of interior-point methods for second-order cone programs which are guaranteed to find the optimal solution. CSCP solves a convergent

  19. Observed bodies generate object-based spatial codes.

    PubMed

    Taylor, Alison; Flynn, Maria; Edmonds, Caroline J; Gardner, Mark R

    2016-09-01

    Contemporary studies of spatial and social cognition frequently use human figures as stimuli. The interpretation of such studies may be complicated by spatial compatibility effects that emerge when researchers employ spatial responses, and participants spontaneously code spatial relationships about an observed body. Yet, the nature of these spatial codes - whether they are location- or object-based, and coded from the perspective of the observer or the figure - has not been determined. Here, we investigated this issue by exploring spatial compatibility effects arising for objects held by a visually presented whole-bodied schematic human figure. In three experiments, participants responded to the colour of the object held in the figure's left or right hand, using left or right key presses. Left-right compatibility effects were found relative to the participant's egocentric perspective, rather than the figure's. These effects occurred even when the figure was rotated by 90° to the left or to the right, and the coloured objects were aligned with the participant's midline. These findings are consistent with spontaneous spatial coding from the participant's perspective and relative to the normal upright orientation of the body. This evidence for object-based spatial coding implies that the domain general cognitive mechanisms that result in spatial compatibility effects may contribute to certain spatial perspective-taking and social cognition phenomena.

  20. Increased rate of observed real-time pulmonary vein isolation with third-generation short-tip cryoballoon.

    PubMed

    Pott, Alexander; Petscher, Kerstin; Messemer, Marvin; Rottbauer, Wolfgang; Dahme, Tillman

    2016-12-01

    Pulmonary vein isolation (PVI) with the cryoballoon is an established treatment for symptomatic atrial fibrillation. The second-generation cryoballoon increased efficacy in comparison to the first-generation cryoballoon. The third-generation cryoballoon was designed with a shorter distal tip to facilitate real-time recording of pulmonary vein (PV) isolation. Here, we compared the rate of real-time recordings of PVI of the second- and third-generation cryoballoon. The incidence of real-time recording of PV isolation and time to PV isolation of the first 37 patients treated with the new third-generation cryoballoon at our center were compared to the last 37 patients treated with the second-generation cryoballoon. One hundred forty-nine pulmonary veins (PVs) were identified in each group. All PVs were isolated successfully with the second- or third-generation cryoballoon. Real-time registration of PVI occurred in 83 PVs (55.7 %) with the second-generation cryoballoon and in 124 PVs (83.2 %) with the third-generation cryoballoon (p < 0.001). The rate of observed real-time PVI was significantly higher with the third-generation cryoballoon for each individual PV. The time-to-isolation was 44 ± 25 s with the second-generation cryoballoon vs. 42 ± 22 s with the third-generation cryoballoon (p = 0.25). In a short-term clinical follow-up, there was no significant difference in atrial arrhythmia recurrence rates between both groups. The third-generation cryoballoon facilitates real-time recording of PV isolation with significantly higher rates of observed time-to-isolation. The time to PV isolation is not different between second- and third-generation cryoballoon.

  1. NPOESS: Delivering the Next Generation of Global, Operational Earth Observations

    NASA Astrophysics Data System (ADS)

    Stockton, D.; Haas, J. M.; Hoffman, C.; Nelson, C.

    2008-12-01

    In the next decade, weather forecasters, climate researchers, and global decision-makers will rely on the National Polar-orbiting Operational Environmental Satellite System (NPOESS) to meet many of their needs for remotely-sensed, Earth science data and information. The first flight of several new instruments will occur in 2010 with the launch of the NPOESS Preparatory Project (NPP). NPP will provide on-orbit testing and validation of sensors, algorithms, ground-based operations, and data processing systems and "bridge" between NASA's Earth Observing System (EOS) research missions and the operational NPOESS mission. Beginning in 2013, NPOESS spacecraft will be launched into afternoon and early morning orbits to provide significantly improved operational capabilities and benefits to satisfy critical civil and national security requirements for space-based, remotely sensed environmental data. The last satellite in the two-orbit NPOESS constellation is expected to continue operations until about 2023-2026. A mid-morning orbit will be occupied by the European Organisation for the Exploitation of Meteorological Satellites (EUMETSAT) Meteorological Operational (MetOp) spacecraft. The joint constellation of NPOESS and MetOp satellites will provide the international community global coverage from advanced atmospheric imaging and sounding instruments with a data refresh rate of approximately four to six hours. Several instruments on NPOESS will improve capabilities for climate monitoring and provide measurements of more than half of 26 essential climate variables. Flight units for the NPP instruments are nearing completion and undergoing final characterization and calibration prior to integration onto the spacecraft. Key components of the NPOESS command, control, and communications system have already been installed and have passed preliminary tests. A key feature of the NPOESS architecture is SafetyNetTM - a system of 15 globally distributed, unmanned ground stations that

  2. Telescope Observations of Interstellar and Circumstellar Ices: Successes of and Need for Laboratory Simulations

    NASA Astrophysics Data System (ADS)

    Boogert, Adwin

    2015-08-01

    Telescope observations of dense clouds and the envelopes and disks surrounding Young Stellar Objects have revealed a large number of spectroscopic signatures caused by absorption, scattering, and sometimes emission by ices [1]. Ices play a key role in the formation and evolution of molecules in space, and some fraction may end up in planet-forming disks as building blocks of, for example,comets. Laboratory simulations are crucial in the derivation of ice abundances, in understanding the interaction between the ices and the refractory grain surfaces, in determining the formation environment and the thermal and energetic processing history of the ices. A relatively recent success story is the strong observational, laboratory, and theoretical evidence for a CO-based chemistry in high density environments, leading to, for example, large abundances of CH3OH, an important precursor to complex molecules [1, 2, 3, 4]. Despite significant progress, more work is needed on the identification of the pronounced 6.85 μm ice band. The observed profile is poorly matched with mixtures of ammonium ion (NH4+) in water [5], despite the good correlation of the observed band strength with the water column density. Also, the role of carbonaceous dust in the ices needs further study. For example, the spectroscopic identification of PAHs embedded in the ices, and their role in the ionization and further chemical evolution of the ices are not fully established [6, 7]. Laboratory work will be essential for the analysis of observations with future facilities, such as the James Webb Space Telescope, the Stratospheric Observatory for Infrared Astronomy, and large aperture ground-based telescopes.[1] Boogert et al. 2015. ARAA 53 (in press)[2] Cuppen et al. 2009. A&A 508, 275[3] Boogert et al. 2011. ApJ 729, 92[4] Öberg et al. 2011. ApJ 740, 109[5] Galvez et al. 2010, ApJ 724, 539[6] Bouwman et al. 2011. A&A 525, 93[7] Hardegree-Ullman et al. 2014. ApJ 784, 172

  3. Rapid Flood Map Generation from Spaceborne SAR Observations

    NASA Astrophysics Data System (ADS)

    Yun, S. H.; Liang, C.; Manipon, G.; Jung, J.; Gurrola, E. M.; Owen, S. E.; Hua, H.; Agram, P. S.; Webb, F.; Sacco, G. F.; Rosen, P. A.; Simons, M.

    2016-12-01

    The Advanced Rapid Imaging and Analysis (ARIA) team has responded to the January 2016 US Midwest Floods along the Mississippi River. Daily teleconferences with FEMA, NOAA, NGA, and USGS, provided information on precipitation and flood crest migration, based on which we coordinated with the Japanese Aerospace Exploration Agency (JAXA) through NASA headquarters for JAXA's ALOS-2 timely tasking over two paths. We produced flood extent maps using ALOS-2 SM3 mode Level 1.5 data that were provided through the International Charter and stored at the US Geological Survey's Hazards Data Distribution System (HDDS) archive. On January 6, the first four frames (70 km x 240 km) were acquired, which included the City of Memphis. We registered post-event SAR images to pre-event images, applied radiometric calibration, took a logarithm of the ratio of the two images. Two thresholds were applied to represent flooded areas that became open water (colored in blue) and flooded areas with tall vegetation (colored in red). The second path was acquired on January 11 further down along the Mississippi River. Seven frames (70 km x 420 km) were acquired and flood maps were created in the similar fashion. The maps were delivered to the FEMA as well as posted on ARIA's public website. The FEMA stated that SAR provides inspection priority for optical imagery and ground response. The ALOS-2 data and the products have been a very important source of information during this response as the flood crest has moved down stream. The SAR data continue to be an important resource during times when optical observations are often not useful. In close collaboration with FEMA and USGS, we also work on other flood events including June 2016 China Floods using European Space Agency's (ESA's) Sentienl-1 data, to produce flood extent maps and identify algorithmic needs and ARIA system's requirements to automate and rapidly produce and deliver flood maps for future events. With the addition of Sentinel-1B

  4. Is Education the Pathway to Success? A Comparison of Second Generation Turkish Professionals in Sweden, France, Germany and the Netherlands

    ERIC Educational Resources Information Center

    Crul, Maurice

    2015-01-01

    Education is often seen as the most important mobility channel for children of immigrants. To what extent is this true? In this article, we look at successful second generation Turkish professionals in Sweden, France, Germany and The Netherlands. What kind of pathways did they take to become a professional? Based on the large quantitative…

  5. "I Ain't Changing Anything": A Case-Study of Successful Generation 1.5 Immigrant College Students' Writing

    ERIC Educational Resources Information Center

    Riazantseva, Anastasia

    2012-01-01

    The purpose of this case-study was to understand the relationship between success in college and L2 academic writing of three Generation 1.5 Russian-speaking middle-class college students and to describe the factors that could have contributed to the levels of academic literacy that these students developed. The following research questions were…

  6. The Parental Investment of First-Generation African American Rural College Graduates in Cultivating College Student Success

    ERIC Educational Resources Information Center

    Allen, Crystal Joi

    2013-01-01

    This basic qualitative study examines the parental investment strategies of first-generation African American rural college graduates in cultivating college student success. Extant literature has demonstrated that the role of the family is necessary to support the college student and that the investment of the parent is paramount to student…

  7. Campus Employment as a High Impact Practice: Relationship to Academic Success and Persistence of First-Generation College Students

    ERIC Educational Resources Information Center

    Savoca, Marianna

    2016-01-01

    The double burden of spiraling costs and limited financial aid has prompted more college students to work more hours than ever. Yet, working more hours can be detrimental to students' academic success and persistence, and first-generation college students are at even higher risk. While institutions cannot control off campus employment students…

  8. Is Education the Pathway to Success? A Comparison of Second Generation Turkish Professionals in Sweden, France, Germany and the Netherlands

    ERIC Educational Resources Information Center

    Crul, Maurice

    2015-01-01

    Education is often seen as the most important mobility channel for children of immigrants. To what extent is this true? In this article, we look at successful second generation Turkish professionals in Sweden, France, Germany and The Netherlands. What kind of pathways did they take to become a professional? Based on the large quantitative…

  9. Campus Employment as a High Impact Practice: Relationship to Academic Success and Persistence of First-Generation College Students

    ERIC Educational Resources Information Center

    Savoca, Marianna

    2016-01-01

    The double burden of spiraling costs and limited financial aid has prompted more college students to work more hours than ever. Yet, working more hours can be detrimental to students' academic success and persistence, and first-generation college students are at even higher risk. While institutions cannot control off campus employment students…

  10. Contributing Factors to Generation 1.5 Students' Successes on the Exit State Assessment for High School

    ERIC Educational Resources Information Center

    Vanderhoef, Deborah E.

    2012-01-01

    This phenomenological narrative study investigated the successes of eight Generation 1.5 high school seniors on the Exit state assessment in English language arts in Texas. These eight participants represented three difficult ethnic cultures, Hispanic, Pakistani and Turkish; within the Hispanic cultures the countries of Mexico and El Salvador were…

  11. The Parental Investment of First-Generation African American Rural College Graduates in Cultivating College Student Success

    ERIC Educational Resources Information Center

    Allen, Crystal Joi

    2013-01-01

    This basic qualitative study examines the parental investment strategies of first-generation African American rural college graduates in cultivating college student success. Extant literature has demonstrated that the role of the family is necessary to support the college student and that the investment of the parent is paramount to student…

  12. Contributing Factors to Generation 1.5 Students' Successes on the Exit State Assessment for High School

    ERIC Educational Resources Information Center

    Vanderhoef, Deborah E.

    2012-01-01

    This phenomenological narrative study investigated the successes of eight Generation 1.5 high school seniors on the Exit state assessment in English language arts in Texas. These eight participants represented three difficult ethnic cultures, Hispanic, Pakistani and Turkish; within the Hispanic cultures the countries of Mexico and El Salvador were…

  13. Comparing the Labor Market Success of Young Adults from Two Generations.

    ERIC Educational Resources Information Center

    Schrammel, Kurt

    1998-01-01

    Contradictory to expectations of labor market analysts, young adults born during the "baby bust" (1965-1976) have thus far been less successful, in terms of earnings and other labor market measures, then their "baby boom" counterparts. (Author)

  14. Thriving Children, Successful Parents: A Two-Generation Approach to Policy

    ERIC Educational Resources Information Center

    Schmit, Stephanie; Matthews, Hannah; Golden, Olivia

    2014-01-01

    A two-generation approach to public policies brings together worlds that are often separated (focusing only on children or only on parents) to modify or create new policies that focus on the needs of parents and children together. Two-generation policies reflect strong research findings that the well-being of parents is a crucial ingredient in…

  15. Exploring the Experiences of Successful First-Generation Community College Students in Florida: A Qualitative Study

    ERIC Educational Resources Information Center

    Patron, Iliana M.

    2012-01-01

    As jobs become more competitive and demanding of specialized training, the presence of first-generation college students will continue to be a growing reality. However, unless the needs of first-generation students are addressed by educational institutions, the motivation experienced by those students to attend college will be short-lived. Even…

  16. Exploring the Experiences of Successful First-Generation Community College Students in Florida: A Qualitative Study

    ERIC Educational Resources Information Center

    Patron, Iliana M.

    2012-01-01

    As jobs become more competitive and demanding of specialized training, the presence of first-generation college students will continue to be a growing reality. However, unless the needs of first-generation students are addressed by educational institutions, the motivation experienced by those students to attend college will be short-lived. Even…

  17. Using Data Known at the Time of Admission to Predict First-Generation College Student Success

    ERIC Educational Resources Information Center

    D'Amico, Mark M.; Dika, Sandra L.

    2013-01-01

    The authors use data known at the time of initial enrollment to explore the first-year GPAs and second-year retention of first-generation (FGCS) and non-first-generation (non-FGCS) college students. The setting was a diverse, public, urban doctoral institution (approximately 50% FGCS and 30% minority). Multiple linear and logistic regressions run…

  18. Recombinant TSH stimulated remnant ablation therapy in thyroid cancer: the success rate depends on the definition of ablation success--an observational study.

    PubMed

    van der Horst-Schrivers, Anouk N A; Sluiter, Wim J; Muller Kobold, Anneke C; Wolffenbuttel, Bruce H R; Plukker, John T M; Bisschop, Peter H; de Klerk, John M; Al Younis, Imad; Lips, Paul; Smit, Jan W; Brouwers, Adrienne H; Links, Thera P

    2015-01-01

    Patients with differentiated thyroid cancer (DTC) are treated with (near)-total thyroidectomy followed by remnant ablation. Optimal radioiodine-131 (131I) uptake is achieved by withholding thyroid hormone (THW), pretreatment with recombinant human Thyrotropin Stimulating Hormone (rhTSH) is an alternative. Six randomized trials have been published comparing THW and rhTSH, however comparison is difficult because an uniform definition of ablation success is lacking. Using a strict definition, we performed an observational study aiming to determine the efficacy of rhTSH as preparation for remnant ablation. Adult DTC patients with, tumor stage T1b to T3, Nx, N0 and N1, M0 were included in a prospective multicenter observational study with a fully sequential design, using a stopping rule. All patients received remnant ablation with 131I using rhTSH. Ablation success was defined as no visible uptake in the original thyroid bed on a rhTSH stimulated 150 MBq 131I whole body scan (WBS) 9 months after remnant ablation, or no visible uptake in the original thyroid bed on a post therapeutic WBS when a second high dose was necessary. After interim analysis of the first 8 patients, the failure rate was estimated to be 69% (90% confidence interval (CI) 20-86%) and the inclusion of new patients had to be stopped. Final analysis resulted in an ablation success in 11 out of 17 patients (65%, 95% CI 38-86%). According to this study, the efficacy of rhTSH in the preparation of 131I ablation therapy is inferior, when using a strict definition of ablation success. The current lack of agreement as to the definition of successful remnant ablation, makes comparison between different ablation strategies difficult. Our results point to the need for an international consensus on the definition of ablation success, not only in routine patient's care but also for scientific reasons. Dutch Trial Registration NTR2395.

  19. Procedural difficulties during successful intubation in octogenarians: A prospective observational study.

    PubMed

    Bryan, Y F; Johnson, K N

    2017-03-30

    Octogenarians undergo anatomic and physiopathologic degradation, making airway management problematic, specific to intubation, bag mask ventilation, leading to desaturation and aspiration. Our study's aim was to examine the process of airway management regarding the steps involved in intubation and any deviations or delays in the tasks. An institutional review board-approved difficult airway prospective observational study in older adults was conducted. Inclusion criteria included airway features indicative of difficult airway, history of failed intubation, the planned use of specialized airway devices, and/or expected airway complications due to comorbidities. Patients 80 years and older were analyzed. Demographic data collected were age, weight, BMI, gender, ASA classification, airway indices, diagnosis, and procedures. Problems with intubation (INT) (≥3 intubation attempts), laborious assisted ventilation (VEN) (2-person and/or application of CPAP>20cmH2O), and complications with oxygenation (OXY) (SpO2<95%) were analyzed. Of the 41 patients enrolled in the study, 3 (7.3%) had all 3: problematic (INT), laborious (VEN), and desaturated (OXY); 8 (19.5%) patients experienced problematic (INT), 20 (48.8%) were described as laborious (VEN), and 14 (34.1%) experienced complications with (OXY). In octogenarians, we found a low incidence of difficulty with INT-VEN-OXY together. However, bag mask ventilation was found to be laborious with a high incidence of desaturation. Success rate of INT as a sole metric may not accurately describe the process of the intubation. We recommend alternative airway devices and techniques and the establishment of protocols for airway management in the elderly. Copyright © 2017 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Publicado por Elsevier España, S.L.U. All rights reserved.

  20. Remote automated multi-generational growth and observation of an animal in low Earth orbit

    PubMed Central

    Oczypok, Elizabeth A.; Etheridge, Timothy; Freeman, Jacob; Stodieck, Louis; Johnsen, Robert; Baillie, David; Szewczyk, Nathaniel J.

    2012-01-01

    The ultimate survival of humanity is dependent upon colonization of other planetary bodies. Key challenges to such habitation are (patho)physiologic changes induced by known, and unknown, factors associated with long-duration and distance space exploration. However, we currently lack biological models for detecting and studying these changes. Here, we use a remote automated culture system to successfully grow an animal in low Earth orbit for six months. Our observations, over 12 generations, demonstrate that the multi-cellular soil worm Caenorhabditis elegans develops from egg to adulthood and produces progeny with identical timings in space as on the Earth. Additionally, these animals display normal rates of movement when fully fed, comparable declines in movement when starved, and appropriate growth arrest upon starvation and recovery upon re-feeding. These observations establish C. elegans as a biological model that can be used to detect changes in animal growth, development, reproduction and behaviour in response to environmental conditions during long-duration spaceflight. This experimental system is ready to be incorporated on future, unmanned interplanetary missions and could be used to study cost-effectively the effects of such missions on these biological processes and the efficacy of new life support systems and radiation shielding technologies. PMID:22130552

  1. Remote automated multi-generational growth and observation of an animal in low Earth orbit.

    PubMed

    Oczypok, Elizabeth A; Etheridge, Timothy; Freeman, Jacob; Stodieck, Louis; Johnsen, Robert; Baillie, David; Szewczyk, Nathaniel J

    2012-03-07

    The ultimate survival of humanity is dependent upon colonization of other planetary bodies. Key challenges to such habitation are (patho)physiologic changes induced by known, and unknown, factors associated with long-duration and distance space exploration. However, we currently lack biological models for detecting and studying these changes. Here, we use a remote automated culture system to successfully grow an animal in low Earth orbit for six months. Our observations, over 12 generations, demonstrate that the multi-cellular soil worm Caenorhabditis elegans develops from egg to adulthood and produces progeny with identical timings in space as on the Earth. Additionally, these animals display normal rates of movement when fully fed, comparable declines in movement when starved, and appropriate growth arrest upon starvation and recovery upon re-feeding. These observations establish C. elegans as a biological model that can be used to detect changes in animal growth, development, reproduction and behaviour in response to environmental conditions during long-duration spaceflight. This experimental system is ready to be incorporated on future, unmanned interplanetary missions and could be used to study cost-effectively the effects of such missions on these biological processes and the efficacy of new life support systems and radiation shielding technologies.

  2. Moving Beyond Access: College Success for Low-Income, First-Generation Students

    ERIC Educational Resources Information Center

    Engle, Jennifer; Tinto, Vincent

    2008-01-01

    Given the pressure to remain competitive in the global knowledge economy, it is in the shared national interest to act to increase the number of students who not only enter college, but more importantly, earn their degrees. Changing national demographics requires a refocus of efforts on improving postsecondary access and success among populations…

  3. When Success Is the Only Option: Designing Competency-Based Pathways for Next Generation Learning

    ERIC Educational Resources Information Center

    Sturgis, Chris; Patrick, Susan

    2010-01-01

    This exploration into competency-based innovation at the school, district, and state levels suggests that competency-based pathways are a re-engineering of this nation's education system around learning--a re-engineering designed for success in which failure is no longer viable. This discussion draws on interviews and site visits with innovators…

  4. Career Choice among Second-Generation Korean-Americans: Reflections of a Cultural Model of Success.

    ERIC Educational Resources Information Center

    Kim, Eun-Young

    1993-01-01

    Examines the pattern of career choice among 23 female and 17 male Korean-American college students in California, and analyzes how this pattern reflects their immigrant parents' cultural model of success and subsequent educational strategies. Explores the model as a family and community force, and considers its costs. (SLD)

  5. Community College Succession Planning: Preparing the Next Generation of Women for Leadership Roles

    ERIC Educational Resources Information Center

    Luzebetak, Angela Kaysen

    2010-01-01

    The purpose of this study was to explore strategies to enable community colleges to develop and cultivate women for leadership roles through succession planning. According to the American Association of Community Colleges (AACC), the pace of administrative and other key staff retirements exceeds the pace at which these positions are being…

  6. Student Generated Recommendations for Enhancing Success in Secondary Science and Mathematics

    ERIC Educational Resources Information Center

    Conboy, Joseph E.; Fonseca, Jesuina M. B.

    2009-01-01

    One frequently overlooked approach to improving academic success is the simple technique of listening to the students. Students are uniquely positioned to understand the nature of school problems, and their perceptions can be useful in forming solutions to problems of academic failure and school leaving. In this study, science-tracked secondary…

  7. Career Choice among Second-Generation Korean-Americans: Reflections of a Cultural Model of Success.

    ERIC Educational Resources Information Center

    Kim, Eun-Young

    1993-01-01

    Examines the pattern of career choice among 23 female and 17 male Korean-American college students in California, and analyzes how this pattern reflects their immigrant parents' cultural model of success and subsequent educational strategies. Explores the model as a family and community force, and considers its costs. (SLD)

  8. Experimental observation of hot tail runaway electron generation in TEXTOR disruptions

    NASA Astrophysics Data System (ADS)

    Zeng, L.; Koslowski, H. R.; Liang, Y.; Lvovskiy, A.; Lehnen, M.; Nicolai, D.; Pearson, J.; Rack, M.; Denner, P.; Finken, K. H.; Wongrach, K.; Wongrach

    2015-08-01

    Experimental evidence supporting the theory of hot tail runaway electron (RE) generation has been identified in TEXTOR disruptions. With higher temperature, more REs are generated during the thermal quench. Increasing the RE generation by increasing the temperature, an obvious RE plateau is observed even with low toroidal magnetic field (1.7 T). These results explain the previously found electron density threshold for RE generation.

  9. First-Generation, Low-Income Students: Strategies for Success at Lyndon State College

    ERIC Educational Resources Information Center

    Dalton, Donna; Moore, Carol A.; Whittaker, Robert

    2009-01-01

    Lyndon State College is a small, four-year public college in the rural Northeast Kingdom of Vermont. In an effort to improve its first-year retention rate, two years ago the authors began to analyze which students return to Lyndon for their second year of college. They found that more than 60% of the students were first-generation college students…

  10. Low Income, First Generation Community College Students: Reflections on Their Success and Their Motivations

    ERIC Educational Resources Information Center

    Munoz, Ramona Marie

    2012-01-01

    Scope and Method of Study: The purpose of this qualitative study was to identify the factors that supported low-income first-generation (LIFG) transfer graduates of four-year institutions in their persistence at the community college level. Specifically, this study focused on students who started at a community college in a Mid-Western State and…

  11. Shaping a Healthier Generation: Successful State Strategies to Prevent Childhood Obesity

    ERIC Educational Resources Information Center

    Mulheron, Joyal; Vonasek, Kara

    2009-01-01

    Studies show that childhood obesity has reached epidemic proportions in the United States. Today, more than 23 million American children--or nearly one in every three--are overweight or obese. If childhood obesity is left unaddressed, a generation of individuals could face health, social, and economic challenges that promise to stress government…

  12. Observation and Modeling of Tsunami-Generated Gravity Waves in the Earth’s Upper Atmosphere

    DTIC Science & Technology

    2015-10-08

    Observation and modeling of tsunami-generated gravity waves in the earth’s upper atmosphere 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...for public release; distribution is unlimited. Observation and modeling of tsunami-generated gravity waves in the earth’s upper atmosphere Sharon...viscosity), and reconstruct the GW field. We would then apply our models to several observed tsunamis, and calculate the GW field in the

  13. Effect of manganese and calcium deficiency on the growth and oxygen exchange of Scenedesmus intermedius cultured for successive generations.

    PubMed

    Adam, M S; Issa, A A

    2000-01-01

    The green alga Scenedesmus intermedius was grown in synchronous culture under manganese or calcium deficiency for six successive generations. The growth rate, pigment and protein contents gradually decreased in comparison with the control. In Mn-deficient cells, the rate of oxygen evolution was sharply decreased. This inhibition was restored to normal in less than 1 h (40-60 min) by adding Mn salt to the suspension medium. In Ca-deficient cells, the inhibition of photosynthesis appears to be irreversible.

  14. Improving lead generation success through integrated methods: transcending 'drug discovery by numbers'.

    PubMed

    Campbell, James B

    2010-12-01

    Key methodologies such as HTS and combinatorial chemistry have allowed pharmaceutical discovery to focus on identifying promising drug candidates through the use of statistics. Thus, amassing large data sets from large-scale screening campaigns of ever-increasing corporate compound collections was expected to deliver unprecedented success for the pharmaceutical industry. This feature review explores aspects of how the reliance on using numbers to drive discovery has gone awry. Building knowledge equity from the integration of multiple parallel screening assays, workstreams and data sources provides an alternative to driving discovery through statistics. Thus, a more rational approach to creating and inventing new leads and drug opportunities may be pursued.

  15. A century of meteorological observations at Fort Valley Experimental Forest: A cooperative observer program success story (P-53)

    Treesearch

    Daniel P. Huebner; Susan D. Olberding; Byron Peterson; Dino DeSimone

    2008-01-01

    Meteorological observations at Fort Valley Experimental Forest began with its establishment as early silvicultural research made heavy use of meteorological data. The Fort Valley weather data represent the longest climatological record for northern Arizona with records dating back to 1909. Importance of long term meteorological records and access to the weather record...

  16. A new generation of spacecraft pyroautomatic systems as a result of a successful cooperation

    NASA Astrophysics Data System (ADS)

    Kotomin, A. A.; Dushenok, S. A.; Demyanenko, D. B.; Efanov, V. V.; Gorovtsov, V. V.

    2016-12-01

    A new generation of spacecraft pyroautomatic systems is developed as a result of a long-term cooperation of NPO Lavochkin, St. Petersburg State Technological Institute (Technical University), and the Special Design and Technological Bureau (Technolog). Separation systems based on elastic explosives have proven their high efficiency and reliability in a number of Russian and international interplanetary and astrophysical space projects. Advanced devices based on new pyrotechnic compositions are developed.

  17. Observational constraints on atmospheric radiaitve feedbacks: absolute accuracy and next-generation observing systems

    NASA Astrophysics Data System (ADS)

    Dykema, J. A.; Hanssen, L. M.; Mekhontsev, S.; Anderson, J.

    2012-12-01

    The central role of atmospheric radiative feedbacks to understanding and projecting climate change calls for a robust observational system. Recent studies have shown the value of space-based measurements for putting quantitative constraints on a range of radiative feedback processes through a fingerprinting method applied to long-term observational records. More recent work has suggested the value of demonstrably accurate measurements to disentangle model error from observational uncertainties within reanalysis systems, potentially yielding improved representations of feedback processes within just a few years. Both of these methods rely on space-based measurements that can be objectively tested for accuracy on-orbit. A new class of mission has been proposed that incorporates the same type of empirical tests for accuracy as used in the laboratory into a space-based sensor. One example of such a mission is the Climate Absolute Radiance and Refractivity Observatory (CLARREO), a new mission suggested by the 2006 National Research Council Decadal Survey. CLARREO includes three sensor types: thermal infrared, microwave, and reflected shortwave. This paper presents a laboratory demonstration of prototype systems for testing the on-orbit accuracy of a thermal infrared sensor for CLARREO. These systems utilize infrared lasers to provide monochromatic light sources to quantitatively determine the optical properties of materials. These infrared optical properties are major determinants of the on-orbit radiometric performance of a thermal infrared sensor. For this reason, reliable quantitative information (including uncertainty) that tracks any changes in relevant infrared materials over the mission lifetime is essential to objective assessment of instrument accuracy. The practicality of mid-infrared lasers for these applications is due to the availability and continued evolution of compact, high-efficiency Quantum Cascade Lasers (QCLs). These lasers can provide over 100 m

  18. Observation of High-Harmonic Generation from an Atomically Thin Semiconductor [Observation of High Harmonics from and Atomically Thin Semiconductor

    SciTech Connect

    Liu, Hanzhe; Li, Yilei; You, Yongsing; Ghimire, Shambhu; Heinz, Tony; Reis, David A.

    2016-01-01

    We report the observation of nonperturbative high-harmonic generation from monolayer MoS2. Here, the yield is higher in monolayer compared to a single layer of the bulk, an effect attributed to strong electron-hole interactions in the monolayer.

  19. Peer-Assisted Learning in Mathematics: An Observational Study of Student Success

    ERIC Educational Resources Information Center

    Cheng, Dorothy; Walters, Matthew

    2009-01-01

    The Peer-Assisted Learning (PAL) program at the University of Minnesota has drawn from the best practices of Supplemental Instruction, Peer-Led Team Learning, Structured Learning Assistance, the Emerging Scholars Program, and other successful postsecondary peer cooperative learning models to establish guiding principles for structuring learning…

  20. Aptitude of Lymnaea palustris and L. stagnalis to Fasciola hepatica larval development through the infection of several successive generations of 4-mm-high snails.

    PubMed

    Vignoles, P; Rondelaud, D; Dreyfuss, G

    2016-06-01

    Bimiracidial infections of Lymnaea palustris and Lymnaea stagnalis (shell height at exposure, 4 mm) with Fasciola hepatica were carried out during six successive snail generations to determine if prevalence and intensity of snail infection increased over time through descendants issuing from eggs laid by parents already exposed to this digenean. Controls were constituted by a French population of Galba truncatula (a single generation) infected according to the same protocol. In a first experiment performed with the F1 to F5 generations of L. palustris, the prevalence and intensity of F. hepatica infection in snails progressively increased. Immature rediae and a few cercariae-containing rediae of the digenean were observed in L. stagnalis from the F3 generation, but no free cercaria was noted in the bodies of this lymnaeid from the F4 to F6 generations. In another experiment carried out with the F6 generation of L. palustris, the prevalence of F. hepatica infection and the number of shed cercariae were significantly lower in L. palustris than in G. truncatula. This mode of snail infection suggests an explanation for cases of human fasciolosis occurring in central France after the collection of wild watercress from beds where L. palustris was the sole lymnaeid.

  1. Building health research systems: WHO is generating global perspectives, and who's celebrating national successes?

    PubMed

    Hanney, Stephen R; González-Block, Miguel A

    2016-12-28

    In 2016, England's National Institute for Health Research (NIHR) celebrated its tenth anniversary as an innovative national health research system with a focus on meeting patients' needs. This provides a good opportunity to reflect on how the creation of the NIHR has greatly enhanced important work, started in 1991, to develop a health research system in England that is embedded in the National Health Service.In 2004, WHO identified a range of functions that a national health research system should undertake to improve the health of populations. Health Research Policy and Systems (HRPS) has taken particular interest in the pioneering developments in the English health research system, where the comprehensive approach has covered most, if not all, of the functions identified by WHO. Furthermore, several significant recent developments in thinking about health research are relevant for the NIHR and have informed accounts of its achievements. These include recognition of the need to combat waste in health research, which had been identified as a global problem in successive papers in the Lancet, and an increasing emphasis on demonstrating impact. Here, pioneering evaluation of United Kingdom research, conducted through the impact case studies of the Research Excellence Framework, is particularly important. Analyses informed by these and other approaches identified many aspects of NIHR's progress in combating waste, building and sustaining research capacity, creating centres of research excellence linked to leading healthcare institutions, developing research networks, involving patients and others in identifying research needs, and producing and adopting research findings that are improving health outcomes.The NIHR's overall success, and an analysis of the remaining problems, might have lessons for other systems, notwithstanding important advances in many countries, as described in papers in HRPS and elsewhere. WHO's recently established Global Observatory for Health

  2. Stress for invasion success? Temperature stress of preceding generations modifies the response to insecticide stress in an invasive pest insect

    PubMed Central

    Piiroinen, Saija; Lyytinen, Anne; Lindström, Leena

    2013-01-01

    Adaptation to stressful environments is one important factor influencing species invasion success. Tolerance to one stress may be complicated by exposure to other stressors experienced by the preceding generations. We studied whether parental temperature stress affects tolerance to insecticide in the invasive Colorado potato beetle Leptinotarsa decemlineata. Field-collected pyrethroid-resistant beetles were reared under either stressful (17°C) or favourable (23°C) insecticide-free environments for three generations. Then, larvae were exposed to pyrethroid insecticides in common garden conditions (23°C). Beetles were in general tolerant to stress. The parental temperature stress alone affected beetles positively (increased adult weight) but it impaired their tolerance to insecticide exposure. In contrast, offspring from the favourable temperature regime showed compensatory weight gain in response to insecticide exposure. Our study emphasizes the potential of cross-generational effects modifying species stress tolerance. When resistant pest populations invade benign environments, a re-application of insecticides may enhance their performance via hormetic effects. In turn, opposite effects may arise if parental generations have been exposed to temperature stress. Thus, the outcome of management practices of invasive pest species is difficult to predict unless we also incorporate knowledge of the evolutionary and recent (preceding generations) stress history of the given populations into pest management. PMID:23467574

  3. Adaptation of Lymnaea fuscus and Radix balthica to Fasciola hepatica through the experimental infection of several successive snail generations

    PubMed Central

    2014-01-01

    Background High prevalence of Fasciola hepatica infection (>70%) was noted during several outbreaks before the 2000s in several French farms where Galba truncatula is lacking. Other lymnaeids such as Lymnaea fuscus, L. glabra and/or Radix balthica are living in meadows around these farms but only juvenile snails can sustain complete larval development of F. hepatica while older snails were resistant. The low prevalence of infection (<20%) and limited cercarial production (<50 cercariae per infected snail) noted with these juveniles could not explain the high values noted in these cattle herds. As paramphistomosis due to Calicophoron daubneyi was not still noted in these farms, the existence of another mode of infection was hypothesized. Experimental infection of several successive generations of L. glabra, originating from eggs laid by their parents already infected with this parasite resulted in a progressive increase in prevalence of snail infection and the number of shed cercariae. The aim of this paper was to determine if this mode of snail infection was specific to L. glabra, or it might occur in other lymnaeid species such as L. fuscus and R. balthica. Methods Five successive generations of L. fuscus and R. balthica were subjected to individual bimiracidial infections in the laboratory. Resulting rediae and cercariae in the first four generations were counted after snail dissection at day 50 p.e. (20°C), while the dynamics of cercarial shedding was followed in the F5 generation. Results In the first experiment, prevalence and intensity of F. hepatica infection in snails progressively increased from the F1 (R. balthica) or F2 (L. fuscus) generation. In the second experiment, the prevalence of F. hepatica infection and the number of shed cercariae were significantly lower in L. fuscus and R. balthica (without significant differences between both lymnaeids) than in G. truncatula. Conclusion The F. hepatica infection of several successive snail generations

  4. Adaptation of Lymnaea fuscus and Radix balthica to Fasciola hepatica through the experimental infection of several successive snail generations.

    PubMed

    Rondelaud, Daniel; Titi, Amal; Vignoles, Philippe; Mekroud, Abdeslam; Dreyfuss, Gilles

    2014-07-01

    High prevalence of Fasciola hepatica infection (>70%) was noted during several outbreaks before the 2000s in several French farms where Galba truncatula is lacking. Other lymnaeids such as Lymnaea fuscus, L. glabra and/or Radix balthica are living in meadows around these farms but only juvenile snails can sustain complete larval development of F. hepatica while older snails were resistant. The low prevalence of infection (<20%) and limited cercarial production (<50 cercariae per infected snail) noted with these juveniles could not explain the high values noted in these cattle herds. As paramphistomosis due to Calicophoron daubneyi was not still noted in these farms, the existence of another mode of infection was hypothesized. Experimental infection of several successive generations of L. glabra, originating from eggs laid by their parents already infected with this parasite resulted in a progressive increase in prevalence of snail infection and the number of shed cercariae. The aim of this paper was to determine if this mode of snail infection was specific to L. glabra, or it might occur in other lymnaeid species such as L. fuscus and R. balthica. Five successive generations of L. fuscus and R. balthica were subjected to individual bimiracidial infections in the laboratory. Resulting rediae and cercariae in the first four generations were counted after snail dissection at day 50 p.e. (20°C), while the dynamics of cercarial shedding was followed in the F5 generation. In the first experiment, prevalence and intensity of F. hepatica infection in snails progressively increased from the F1 (R. balthica) or F2 (L. fuscus) generation. In the second experiment, the prevalence of F. hepatica infection and the number of shed cercariae were significantly lower in L. fuscus and R. balthica (without significant differences between both lymnaeids) than in G. truncatula. The F. hepatica infection of several successive snail generations, coming from parents infected with this

  5. An evaluation of the nursing practice environment and successful change management using the new generation Magnet Model.

    PubMed

    Grant, Bettyanne; Colello, Sandra; Riehle, Martha; Dende, Denise

    2010-04-01

    To discuss the new Magnet Model as it relates to the successful implementation of a practice change. There is growing international interest in the Magnet Recognition Programme. The latest generation of the Magnet Model has been designed not only as a road map for organizations seeking to achieve Magnet recognition but also as a framework for nursing practice and research in the future. The Magnet Model was used to identify success factors related to a practice change and to evaluate the nursing practice environment. Even when proposed changes to practice are evidence based and thoughtfully considered, the nurses' work environment must be supportive and empowering in order to yield successful and sustainable implementation of new practice. Success factors for implementation of a practice change can be illuminated by aligning environmental characteristics to the components of the new Magnet Model. The Magnet Model provides an exceptional framework for building an agile and dynamic work force. Thoughtful consideration of the components and inter-relationships represented in the new model can help to both predict and ensure organizational vitality.

  6. Engineering of the rose flavonoid biosynthetic pathway successfully generated blue-hued flowers accumulating delphinidin.

    PubMed

    Katsumoto, Yukihisa; Fukuchi-Mizutani, Masako; Fukui, Yuko; Brugliera, Filippa; Holton, Timothy A; Karan, Mirko; Nakamura, Noriko; Yonekura-Sakakibara, Keiko; Togami, Junichi; Pigeaire, Alix; Tao, Guo-Qing; Nehra, Narender S; Lu, Chin-Yi; Dyson, Barry K; Tsuda, Shinzo; Ashikari, Toshihiko; Kusumi, Takaaki; Mason, John G; Tanaka, Yoshikazu

    2007-11-01

    Flower color is mainly determined by anthocyanins. Rosa hybrida lacks violet to blue flower varieties due to the absence of delphinidin-based anthocyanins, usually the major constituents of violet and blue flowers, because roses do not possess flavonoid 3',5'-hydoxylase (F3'5'H), a key enzyme for delphinidin biosynthesis. Other factors such as the presence of co-pigments and the vacuolar pH also affect flower color. We analyzed the flavonoid composition of hundreds of rose cultivars and measured the pH of their petal juice in order to select hosts of genetic transformation that would be suitable for the exclusive accumulation of delphinidin and the resulting color change toward blue. Expression of the viola F3'5'H gene in some of the selected cultivars resulted in the accumulation of a high percentage of delphinidin (up to 95%) and a novel bluish flower color. For more exclusive and dominant accumulation of delphinidin irrespective of the hosts, we down-regulated the endogenous dihydroflavonol 4-reductase (DFR) gene and overexpressed the Irisxhollandica DFR gene in addition to the viola F3'5'H gene in a rose cultivar. The resultant roses exclusively accumulated delphinidin in the petals, and the flowers had blue hues not achieved by hybridization breeding. Moreover, the ability for exclusive accumulation of delphinidin was inherited by the next generations.

  7. Beyond the lab: observations on the process by which science successfully informs management and policy decisions

    NASA Astrophysics Data System (ADS)

    Flores, S.

    2012-12-01

    Scientific findings inform management decisions and policy products through various ways, these include: synthesis reports, white papers, in-person and web-based seminars (webinars), communication from specialized staff, and seminal peer-reviewed journal articles. Scientists are often told that if they want their science to inform management decisions and policy products that they must: clearly and simply articulate discreet pieces of scientific information and avoid attaching advocacy messages to the science; however, solely relying on these tenants does not ensure that scientific products will infuse the realms of management and policy. The process by which science successfully informs management decisions and policy products rarely begins at the time the results come out of the lab, but rather, before the research is carried out. Having an understanding of the political climate, management needs, agency research agendas, and funding limitations, as well as developing a working relationship with the intended managers and policy makers are key elements to developing the kind of science results and products that often make an impact in the management and policy world. In my presentation I will provide case-studies from California (USA) to highlight the type of coastal, ocean and climate science that has been successful in informing management decisions and policy documents, as well as provide a state-level agency perspective on the process by which this occurs.

  8. Training the next generation of Canadian Clinician-Scientists: charting a path to success.

    PubMed

    Yin, Charles; Steadman, Patrick E; Apramian, Tavis; Zhou, Tianwei E; Ishaque, Abdullah; Wang, Xin; Kuzyk, Alexandra; Warsi, Nebras

    2017-04-26

    Clinician-scientists are physicians with training in both clinical medicine and research that enables them to occupy a unique niche as specialists in basic and translational biomedical research. While there is widespread acknowledgement of the importance of clinician-scientists in today's landscape of evidence-based medical practice, training of clinician-scientists in Canada has been on the decline, with fewer opportunities to obtain funding. With the increasing length of training and lower financial compensation, fewer medical graduates are choosing to pursue such a career. MD-PhD programs, in which trainees receive both medical and research training, have the potential to be an important tool in training the next generation of clinician-scientists; however, MD-PhD trainees in Canada face barriers that include an increase in medical school tuition and a decrease in the amount of financial support. We examined the available data on MD-PhD training in Canada and identified a lack of oversight, a lack of funding and poor mentorship as barriers experienced by MD-PhD trainees. Specific recommendations are provided to begin the process of addressing these challenges, starting with the establishment of an overseeing national body that would track long-term outcome data for MD-PhD trainees. This national body could then function to implement best practices from individual programs across the country and to provide further mentorship and support for early-career physician-scientists. MD-PhD programs have the potential to address Canada's growing shortage of clinician-scientists, and strengthening MD-PhD programs will help to effect positive change.

  9. Successful Treatment of PD Peritonitis Due to Morganella morganii Resistant to Third-Generation Cephalosporins - A Case Report.

    PubMed

    Keskar, Vaibhav; Biyani, Mohan; Amin, Syed Obaid; Knoll, Greg

    2017-01-01

    Morganella morganii is a rare cause of peritonitis in patients on peritoneal dialysis (PD). Most of the reported cases have resorted to a switch to hemodialysis. We herein report a case of peritonitis due to M. morganii resistant to third-generation cephalosporins, which was treated successfully with intraperitoneal (IP) tobramycin followed by oral ciprofloxacin. Early microbiologic diagnosis is essential in the treatment of peritonitis from rare microorganisms such as Morganella morganii, and appropriate antibiotic therapy is the key to avoiding catheter loss and subsequent switch to hemodialysis. Copyright © 2017 International Society for Peritoneal Dialysis.

  10. Successful twilight observations of eta-Aquarid shower in "Unified Churyumov Network"

    NASA Astrophysics Data System (ADS)

    Steklov, E. A.; Kruchynenko, V. G.; Steklov, A. F.; Vidmachenko, A. P.; Dashkiev, G. N.

    2017-05-01

    On March 29 2013, on the left bank of the Dnieper in Kiev, young amateur astronomers, in the evening twilight, observed almost simultaneous invasion of three large fragments of meteoroid. Then four images were obtained. It was proposed to create a "Club of Fireball tracks observers". As a result, in Kiev region a network of photo hunters on twilight and daytime tracks of dangerous invasions into the sky above us - was formed. This "Unified Churyumov Network" has been in operation for four years. From April 19 to May 28, we are actively observing a meteor shower of eta-Aquarids. The particles of this meteor shower are fragments of nucleus of the famous Halley comet. In May 10 at the same time four observers photographed very interesting trail of invasion from four points of Kiev. In the last few years, the authors have registered several hundred small and dozens of larger invasions in the sky over Kiev and Kiev region.

  11. Extreme-Wind Observation Capability for a Next Generation Satellite Wind Scatterometer Instrument

    NASA Astrophysics Data System (ADS)

    Stoffelen, Ad; van Zadelhoff, Gerd Jan; Belmonte, Maria; Chang, Paul; Vachon, Paris; Lin, Chung-Chi; Accadia, Christophe

    2013-04-01

    The ocean surface vector wind information, derived from satellite-based wind scatterometer observations, is one of the essential inputs for operational numerical weather prediction (NWP) services. The local wind speed and direction are retrieved from accurate measurements of the ocean surface backscatter, performed from at least three largely-spaced satellite positions during an over-flight. As a result, each of the wind resolution cells is characterised by a set of radar backscatter coefficients which are associated with their respective observation angles in azimuth and elevation with respect to the cell. The azimuth anisotropy of the backscatter coefficient with respect to the wind direction and its magnitude as a function of the wind speed, as captured in a so-called geophysical model function (GMF), are exploited in order to retrieve a unique vector wind. The current generation of scatterometer instruments operate at C-band with a single vertical polarisation (i.e. VV), or at Ku-band with VV for the first beam and HH for the second beam. The co-polarised radar backscatter, i.e., VV and to a lesser extend HH, saturate above a wind speed of about 25 to 30 m/s, which imposes a serious limitation on the capability of the existing observation systems. Such a limitation leads, e.g., to misestimation of extreme winds, errors in storm predictions and limitations in weather prediction warnings. Recently, observations of storm events along the North American coasts by Radarsat-2 and comparisons with in-situ buoy data revealed a high sensitivity of C-band cross-polarised backscatter signal intensity (i.e. VH or HV) with high wind speeds. This prompted the ocean vector wind community to further explore the limit of the cross-polar response. Establishing a new GMF requires accurate in-situ information of the vector wind field together with collocated scatterometer observation data, but these are extremely rare at extreme winds. A more successful collocation approach

  12. Integrated Observations of Convective Clouds during MC3E - Preliminary Analysis, Successes and Challenges

    NASA Astrophysics Data System (ADS)

    Kollias, P.; Jensen, M. P.; Petersen, W. A.; Collis, S. M.; Giangrande, S.; North, K. W.; Borque, P.; Chandra, A.; Luke, E. P.

    2011-12-01

    The Midlatitude Continental Convective Clouds Experiment (MC3E) a joint field program involving NASA Global Precipitation Measurement Program and the DOE Atmospheric Radiation Measurements Program, was conducted in north-central Oklahoma during the April to June 2011 period. This intensive observation period used a new multi-scale observing strategy with the participation of a network of distributed sensors (both passive and active). The approach was to document in 3D not only precipitation, but also clouds, winds, and moisture in an attempt to provide a holistic view of convective clouds and their feedback with the environment. Preliminary synthesis and analysis of the observations collected from a wide variety of sensors will be presented. This includes an overview of the cloud and precipitation conditions observed during MC3E. Advancements in our ability to measure new atmospheric variables and improve the quality of traditional measurements will be highlighted. Remaining gaps in measuring key atmospheric variables and challenges associated with the synthesis of the multisensory observations and their use for model evaluation will be discussed.

  13. Observing Preschoolers' Social-Emotional Behavior: Structure, Foundations, and Prediction of Early School Success

    ERIC Educational Resources Information Center

    Denham, Susanne A.; Bassett, Hideko Hamada; Thayer, Sara K.; Mincic, Melissa S.; Sirotkin, Yana S.; Zinsser, Katherine

    2012-01-01

    Social-emotional behavior of 352 3- and 4-year-olds attending private childcare and Head Start programs was observed using the Minnesota Preschool Affect Checklist, Revised (MPAC-R). Goals of the investigation included (a) using MPAC-R data to extract a shortened version, MPAC-R/S, comparing structure, internal consistency, test-retest…

  14. Analysis of Pre-Analytic Factors Affecting the Success of Clinical Next-Generation Sequencing of Solid Organ Malignancies.

    PubMed

    Chen, Hui; Luthra, Rajyalakshmi; Goswami, Rashmi S; Singh, Rajesh R; Roy-Chowdhuri, Sinchita

    2015-08-28

    Application of next-generation sequencing (NGS) technology to routine clinical practice has enabled characterization of personalized cancer genomes to identify patients likely to have a response to targeted therapy. The proper selection of tumor sample for downstream NGS based mutational analysis is critical to generate accurate results and to guide therapeutic intervention. However, multiple pre-analytic factors come into play in determining the success of NGS testing. In this review, we discuss pre-analytic requirements for AmpliSeq PCR-based sequencing using Ion Torrent Personal Genome Machine (PGM) (Life Technologies), a NGS sequencing platform that is often used by clinical laboratories for sequencing solid tumors because of its low input DNA requirement from formalin fixed and paraffin embedded tissue. The success of NGS mutational analysis is affected not only by the input DNA quantity but also by several other factors, including the specimen type, the DNA quality, and the tumor cellularity. Here, we review tissue requirements for solid tumor NGS based mutational analysis, including procedure types, tissue types, tumor volume and fraction, decalcification, and treatment effects.

  15. Alteration of chromosome behavior and synchronization of parental chromosomes after successive generations in Brassica napus x Orychophragmus violaceus hybrids.

    PubMed

    Zhao, Zhigang; Ma, Ni; Li, Zaiyun

    2007-02-01

    In an earlier study, the progenies of intergeneric hybrids Brassica napus (2n = 38) x Orychophragmus violaceus (2n = 24) were investigated in successive generations (F1-F4) for the cytological phenomenon of parental genome separation during mitotic and meiotic division. In the present study, inbred lines (F5-F8) derived from 1 such hybrid were characterized for morphology, chromosome pairing behaviour, and genome composition. One F5 plant (2n = 31) with slightly yellow petals and 12:19 and 15:16 segregation ratios in its pollen mother cells (PMCs) produced F6 plants with distinct morphological characteristics and wide variations in fertility and chromosome numbers (2n = 25-38). F7 and F8 lines with distinctive morphology and wide ranges in chromsome numbers were established. In PMCs of F7 plants from 4 F6 plants, 0-12 labelled chromosomes from O. violaceus, which predominantly appeared as bivalents, were identified by genomic in situ hybridization. They behaved synchronously with B. napus chromosomes during meiotic division. The results provide molecular cytogenetic evidence of the inclusion of O. violaceus chromosomes in the original hybrids and the cytology in the hybrids documented earlier. They also show that chromosome behaviour was altered and the parental chromosomes became synchronized after successive generations.

  16. Infantile spasms and 15q11.2q13.1 chromosome duplication in two successive generations.

    PubMed

    Riikonen, Raili Sylvia; Wallden, Tiina; Kokkonen, Hannaleena

    2016-01-01

    Familial cases of West syndrome have been reported only in Japan. In that study no chromosomal analyses were made. It has been suggested that microarray analysis should be included in the diagnostic evaluation of patients with infantile spasms and developmental delay, when an evaluation for structural brain lesions and metabolic disorders reveal no abnormal findings. We report here the first case of infantile spasms and 15q11.2q13.1 chromosome duplication in two successive generations. The daughter and mother with infantile spasms, and the autistic son had the duplication. The clinical course of infantile spasms was very similar in the mother and daughter. The spasms were primarily considered to be of unknown aetiology. Chromosomal microarray analysis revealed a 6.2 Mb size 15q11.2q13.1 duplication. The duplication belongs to the 15q11q13 duplication syndrome (OMIM 608636) which when maternally derived is characterised by neuro-behavioural disorders like autism, hypotonia, cognitive deficit, language delay and epilepsy. The proportion of patients with unknown aetiology for infantile spasms will decrease when more careful chromosomal studies are made. Our report expands the phenotype of chromosome 15q duplication syndrome and is the first report of this abnormality in two successive generations of infantile spasms.

  17. Does EMLA cream application interfere with the success of venipuncture or venous cannulation? A prospective multicenter observational study.

    PubMed

    Schreiber, S; Ronfani, L; Chiaffoni, G P; Matarazzo, L; Minute, M; Panontin, E; Poropat, F; Germani, C; Barbi, E

    2013-02-01

    Venipuncture and intravenous cannulation are the most common painful procedures performed on children. The most widely used topical anesthetic is eutectic mixture of local anesthetics (EMLA). EMLA use is associated with a transient cutaneous vasoconstriction which can make it difficult to identify veins. We assessed with a prospective, multicenter, observational study whether EMLA interferes with venipuncture and intravenous cannulation. The primary study outcome was a success at first attempt in the course of venipuncture or venous cannulation. The study enrolled 388 children; 255 of them received EMLA and 133 did not. Eighty-six percent of procedures were successful at the first attempt in the EMLA group and 76.7 % in the no EMLA group. In this study, EMLA use did not interfere with the success of venipuncture or venous cannulation in children.

  18. Observation and Modeling of Tsunami-Generated Gravity Waves in the Earth’s Upper Atmosphere

    DTIC Science & Technology

    2014-10-15

    Observation and modeling of tsunami -generated gravity waves in the earth’s upper atmosphere 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR...ABSTRACT Build a compatible set of models which 1) calculate the atmospheric gravity waves (GWs) excited by a tsunami , 2) propagate these GWs into...modeling of tsunami -generated gravity waves in the earth’s upper atmosphere Sharon L. Vadas NWRA/CoRA 3380 S. Mitchell Lane Boulder, CO 80301, USA phone

  19. Observational study of bone accretion during successful weight loss in obese adolescents.

    PubMed

    Stettler, Nicolas; Berkowtiz, Robert I; Cronquist, Joanna L; Shults, Justine; Wadden, Thomas A; Zemel, Babette S; Leonard, Mary B

    2008-01-01

    To assess bone mineral content (BMC) among obese adolescents who lose weight during a critical period for bone accretion. Whole body, lumbar spine, lower, and upper limb BMC were measured in 62 obese adolescents who completed an intensive 12-month weight loss trial. BMC was adjusted for height (z -scores) using data from a reference group of 66 adolescents (who were 18% overweight). At baseline, the BMC of the obese group was higher than the reference group. During the 12-month weight loss program, unadjusted BMC increased among the obese adolescents, despite successful weight loss. After adjustment for height, whole body BMC did not change significantly from baseline to 12 months (mean +/- s.d.: 1.08 +/- 0.67 to 1.06 +/- 0.67, P = 0.7). Region-specific BMC-for-height however decreased for the lower (1.07 +/- 0.57 to 0.95 +/- 0.59, P < 0.001) and upper (1.29 +/- 0.56 to 1.18 +/- 0.57, P = 0.01) limbs, but lumbar spine BMC-for-height increased (0.14 +/- 1.06 to 0.40 +/- 0.94, P < 0.001). These changes were largely and independently explained by changes in lean and fat mass. This study confirms that obese adolescents have high BMC for height and suggests that, unlike adults, their BMC continues to increase during weight loss and remains higher than the BMC of a reference group. After adjustment for growth-related changes, lower and upper limb BMC appears to decrease, while lumbar spine BMC appears to increase. These results suggest that to optimize the health benefits of weight loss among obese adolescents, their bone health should be better understood and addressed.

  20. The seasonal succession of modern planktonic foraminifera: Sediment traps observations from southwest Taiwan waters

    NASA Astrophysics Data System (ADS)

    Lin, Hui-Ling

    2014-08-01

    The seasonal succession and stable isotope compositions of living planktonic foraminifera collected in sediment traps from the continental shelf/slope off southwest Taiwan were investigated. Sediment trap moorings were deployed at water depths of ~816 m and ~233/250 m during October-November 2009, March-April 2010 and July-August 2010. The sampling duration was 3 days for each collecting cup, yielding 36 days/12 cups per individual mooring over the three sampling periods. All planktonic foraminiferal tests greater than 150 μm were picked, identified and counted for the faunal census. The variations in shell abundance (#/g; number of specimens per gram of original bulk sample) and size frequency show a pattern which seems to be related to the lunar cycle: shell abundances increase from low concentration at the new moon and reach their maxima before the full moon. Occurrences of larger foraminiferal shells also gradually increase as the collection approaching to full moon. The faunal assemblages were dominated by Globigerinella aequilateralis, Globigerinoides sacculifer, Globorotalia menardii, Globigerinoides ruber, Neogloboquadrina dutertrei, and Pulleniatina obliquiloculata; these six species constituting 30-80% of all foraminiferal tests found in the sediment traps. The seasonal contrast within the faunal assemblage between these three deployment periods, however, is not very evident except for the relative abundance of G. sacculifer and G. ruber. G. ruber is more abundant in summer than in spring whereas G. sacculifer shows an inverse pattern. Seasonal differences in the δ18O of P. obliquiloculata, G. sacculifer and G. ruber can be well explained by temperature profiles in the water column, while variations of δ13C are not related to the chlorophyll concentration hence to productivity. In addition, the calcifying depths reflected by three species are estimated to be ~40 m for G. ruber; ~60 m for G. sacculifer; and >80 m for P. obliquiloculata.

  1. Condom-catheter tamponade for the treatment of postpartum haemorrhage and factors associated with success: a prospective observational study.

    PubMed

    Aderoba, A K; Olagbuji, B N; Akintan, A L; Oyeneyin, O L; Owa, O O; Osaikhuwuomwan, J A

    2017-10-01

    To determine the outcomes and factors associated with postpartum haemorrhage (PPH) treatment with condom-catheter uterine balloon tamponade (C-UBT). Prospective observational study. A secondary healthcare facility in Nigeria. Women with PPH refractory to first-line treatment. Demographic and clinical characteristics were compared in women with successful and unsuccessful treatment. Univariate and multivariate logistic regression analyses were used to examine the association of these characteristics with successful treatment. The success rate of C-UBT, factors associated with success, and maternal morbidity rates in both successful and unsuccessful treatment groups. Overall, 203/229 (88.6%) women had successful treatment. Women with successful treatment had lower mean blood loss (1248.8 ± 701.3 ml versus 3434.6 ± 906.6 ml; P < 0.0001), lower occurrence of blood transfusion [139 (68.5%) versus 26 (100%); P < 0.0001], lower intensive care unit admission rates [5 (2.5%) versus 20 (76.9%); P < 0.0001], and lower occurrence of infectious morbidities [3 (1.5%) versus 7 (26.9%); P < 0.0001]. In the regression model with two factors, caesarean section (adjusted odds ratio, aOR 0.17; 95% confidence interval, 95% CI 0.07-0.40) was associated with lower success rates compared with vaginal delivery. In the regression model with three factors, advanced maternal age (aOR 0.31; 95% CI 0.11-0.90) and caesarean section (aOR 0.17; 95% CI 0.07-0.41) were associated with lower success rates in comparison with younger maternal age and vaginal delivery, respectively. Second-line PPH treatment with C-UBT is effective, and is associated with low maternal morbidity rates. Advanced maternal age and caesarean section are associated with lower success rates. Condom-catheter tamponade is a useful second-line treatment modality for intractable postpartum haemorrhage. © 2016 Royal College of Obstetricians and Gynaecologists.

  2. A theory of electron cyclotron waves generated along auroral field lines observed by ground facilities

    NASA Technical Reports Server (NTRS)

    Wu, C. S.; Yoon, Peter H.; Freund, H. P.

    1989-01-01

    A generation mechanism for radio waves in the frequency range 150 - 700 kHz observed by ground facilities is suggested in terms of an electromagnetic electron cyclotron instability driven by auroral electrons. The excited waves can propagate downward along the ambient magnetic field lines and are thus observable with ground facilities. The trapped auroral electrons are supposed to play an important role in the generation process, because they give rise to a thermal anisotropy which consequently leads to the instability. The present work is a natural extension of the theory proposed earlier by Wu et al. (1983) which was discussed in a different context but may be used to explain the observed waves originated at low altitudes. This paper presents a possible wave generation mechanism valid in the entire auroral field-line region of interest.

  3. Telescope Observations of Interstellar and Circumstellar Ices: Successes of and Need for Laboratory Simulations

    NASA Astrophysics Data System (ADS)

    Boogert, A. C. A.

    2016-10-01

    Ices play a key role in the formation of simple and complex molecules in dense molecular clouds and in the envelopes and protoplanetary disks surrounding young stars. Some fraction of the interstellar ices may become building blocks of comets, and thus be delivered to the early Earth. Laboratory simulations have proven to be crucial in the derivation of ice abundances, in quantifying reaction rates on cold grain surfaces, in determining the thermal and energetic processing history of the ices, and in understanding the interaction between the ices and the underlying refractory grain surfaces. In this invited topical paper I will review possible ways forward in improving our knowledge of the composition of the ices, as many signatures in the interstellar spectra are still poorly identified. I will also emphasize the observed importance of thermal processing of the ices (crystallization, segregation), which likely affects the chemistry after the initial dominance of grain surface reactions. Continued laboratory work is warranted in view of the upcoming observational data from, for example, the James Webb Space Telescope (JWST), which is ideally suited for ices studies. For an exhaustive review on this topic I refer to Boogert, Gerakines & Whittet (2015).

  4. Observations of an extreme storm in interplanetary space caused by successive coronal mass ejections.

    PubMed

    Liu, Ying D; Luhmann, Janet G; Kajdič, Primož; Kilpua, Emilia K J; Lugaz, Noé; Nitta, Nariaki V; Möstl, Christian; Lavraud, Benoit; Bale, Stuart D; Farrugia, Charles J; Galvin, Antoinette B

    2014-03-18

    Space weather refers to dynamic conditions on the Sun and in the space environment of the Earth, which are often driven by solar eruptions and their subsequent interplanetary disturbances. It has been unclear how an extreme space weather storm forms and how severe it can be. Here we report and investigate an extreme event with multi-point remote-sensing and in situ observations. The formation of the extreme storm showed striking novel features. We suggest that the in-transit interaction between two closely launched coronal mass ejections resulted in the extreme enhancement of the ejecta magnetic field observed near 1 AU at STEREO A. The fast transit to STEREO A (in only 18.6 h), or the unusually weak deceleration of the event, was caused by the preconditioning of the upstream solar wind by an earlier solar eruption. These results provide a new view crucial to solar physics and space weather as to how an extreme space weather event can arise from a combination of solar eruptions.

  5. Health, growth and reproductive success of mice exposed to environmentally relevant levels of Ra-226 via drinking water over multiple generations.

    PubMed

    Walsh, Stephanie; Satkunam, Meloja; Su, Ben; Festarini, Amy; Bugden, Michelle; Peery, Harry; Mothersill, Carmel; Stuart, Marilyne

    2015-07-01

    To assess health, growth and reproductive success of mammals exposed for multiple generations to levels of radium-226 known to occur in environments surrounding uranium mines and mills in Canada. The study consisted of a control group and four treatment groups each containing 40 mice (20 males and 20 females) of the CBA/CaJ strain that were continuously exposed to a range of radium-226 levels via drinking water. Breeding was at 8-10 weeks of age and the study was concluded after three breeding cycles. When compared to control mice, constant consumption of drinking water containing 0.012, 0.076, 0.78 and 8.0 Bq/l of radium-226 over four generations of mice did not demonstrably affect physical condition, weight, pregnancy rate, number of pups per litter, sex ratio and bodyweight gain of pups. Between generations, the observed differences in pregnancy rates that were noted in all groups, including controls, seemed to directly correlate with the weight and age of the females at breeding. Based on the endpoints measured on four generations of mice, there is no indication that the consumption of radium-226 via drinking water (at activity concentrations up to 8.0 Bq/l) affects health, growth and reproductive fitness.

  6. Wide-area littoral discreet observation: success at the tactical edge

    NASA Astrophysics Data System (ADS)

    Toth, Susan; Hughes, William; Ladas, Andrew

    2012-06-01

    In June 2011, the United States Army Research Laboratory (ARL) participated in Empire Challenge 2011 (EC-11). EC-11 was United States Joint Forces Command's (USJFCOM) annual live, joint and coalition intelligence, surveillance and reconnaissance (ISR) interoperability demonstration under the sponsorship of the Under Secretary of Defense for Intelligence (USD/I). EC-11 consisted of a series of ISR interoperability events, using a combination of modeling & simulation, laboratory and live-fly events. Wide-area Littoral Discreet Observation (WALDO) was ARL's maritime/littoral capability. WALDO met a USD(I) directive that EC-11 have a maritime component and WALDO was the primary player in the maritime scenario conducted at Camp Lejeune, North Carolina. The WALDO effort demonstrated the utility of a networked layered sensor array deployed in a maritime littoral environment, focusing on maritime surveillance targeting counter-drug, counter-piracy and suspect activity in a littoral or riverine environment. In addition to an embedded analytical capability, the sensor array and control infrastructure consisted of the Oriole acoustic sensor, iScout unattended ground sensor (UGS), OmniSense UGS, the Compact Radar and the Universal Distributed Management System (UDMS), which included the Proxy Skyraider, an optionally manned aircraft mounting both wide and narrow FOV EO/IR imaging sensors. The capability seeded a littoral area with riverine and unattended sensors in order to demonstrate the utility of a Wide Area Sensor (WAS) capability in a littoral environment focused on maritime surveillance activities. The sensors provided a cue for WAS placement/orbit. A narrow field of view sensor would be used to focus on more discreet activities within the WAS footprint. Additionally, the capability experimented with novel WAS orbits to determine if there are more optimal orbits for WAS collection in a littoral environment. The demonstration objectives for WALDO at EC-11 were

  7. The Correlation of Workplace Simulation-Based Assessments With Interns' Infant Lumbar Puncture Success: A Prospective, Multicenter, Observational Study.

    PubMed

    Auerbach, Marc; Fein, Daniel M; Chang, Todd P; Gerard, James; Zaveri, Pavan; Grossman, Devin; Van Ittersum, Wendy; Rocker, Joshua; Whitfill, Travis; Pusic, Martin; Kessler, David O

    2016-04-01

    Little data are available to guide supervisors' decisions regarding when trainees are prepared to safely perform their first procedure on a patient. We aimed to describe the correlation of simulation-based assessments, in the workplace, with interns' first clinical infant lumbar puncture (ILP) success. This is a prospective, observational subcomponent of a larger study of incoming interns at 33 academic medical centers (July 2010 to June 2012) assessing the impact of just-in-time training. When an intern's patient required an ILP, a just-in-time simulation-based skills refresher was conducted with his or her supervisor. At the end of the refresher, supervisors assessed interns' ILP skills on a simulator in the workplace before clinical performance using a four point anchored scale. The primary outcome was the correlation of supervisors' assessment and interns' procedural success. The number needed to assess for this instrument (1 / absolute risk reduction) was calculated. A total of 1600 interns were eligible to participate, and 1215 were enrolled. A total of 297 completed an assessment and a subsequent clinical ILP. Success rates for each scale rating were 29% (18/63) for novice, 39% (51/130) for beginner, 55% (46/83) for competent, and 43% (9/21) for proficient. The correlation coefficient was 0.161 (95% confidence interval, 0.057-0.265), indicating a weak correlation between supervisor rating and success. Success rate was 53% for the ratings of competent or proficient compared with 35% for the ratings of novice or beginner. Using the global rating scale for the summative assessment to determine procedural readiness could lead to 1 fewer patient experiencing a failed ILP for every 6 interns tested (6.2; 95% confidence interval, 4.0-8.5). A simulation-based assessment of interns conducted in the workplace before their first ILP has some value in predicting clinical ILP success.

  8. Soil Moisture Retrievals Using L-band Radiometer Observations in SMEX02: Successes and Challenges

    NASA Astrophysics Data System (ADS)

    Crosson, W. L.; Limaye, A. S.; Laymon, C. A.

    2004-05-01

    Measurements at L-band are widely considered to be optimal for soil moisture remote sensing, taking into account emitting depth and complications arising from roughness and vegetation. Although there is no operational satellite-borne L-band radiometer today, plans are underway to deploy one by the end of the decade. During the Soil Moisture Experiments in 2002 (SMEX02), the Passive and Active L and S-band (PALS) instrument was flown over the Walnut Creek Watershed in Iowa. This agricultural region was selected to facilitate testing of microwave remote sensing algorithms under conditions of highly variable and sometimes dense vegetation cover. L-band brightness temperature observations from PALS were used to retrieve near-surface soil moisture for conditions representative of the dominant corn and soybean land covers in the watershed. Sensitivities of the retrieved soil moisture to surface temperature, surface roughness and the vegetation B parameter have been evaluated for both crops. Retrievals for corn were found to be highly sensitive to the vegetation B parameter, while retrievals for soybeans were most sensitive to surface roughness. The vegetation water content of approximately 4 kg/m2 for the corn sites appears to be high enough to make soil moisture retrievals problematic, but retrievals appear relatively robust for soybeans with a vegetation water content of 0.3-0.7 kg/m2. For both corn and soybeans there is considerable overlap in the parameter spaces (combinations of surface roughness and vegetation B parameter) that yield accurate moisture retrievals for three wet days analyzed, but these parameter values do not translate well to dry conditions. This may indicate potential deficiencies in the roughness and vegetation correction algorithms for agricultural areas and raises concerns about global operational soil moisture retrieval from satellite-borne microwave sensors.

  9. Experimental observation of gravity-capillary solitary waves generated by a moving air-suction

    NASA Astrophysics Data System (ADS)

    Park, Beomchan; Cho, Yeunwoo

    2016-11-01

    Gravity-capillary solitary waves are generated by a moving "air-suction" forcing instead of a moving "air-blowing" forcing. The air-suction forcing moves horizontally over the surface of deep water with speeds close to the minimum linear phase speed cmin = 23 cm/s. Three different states are observed according to forcing speed below cmin. At relatively low speeds below cmin, small-amplitude linear circular depressions are observed, and they move steadily ahead of and along with the moving forcing. As the forcing speed increases close to cmin, however, nonlinear 3-D gravity-capillary solitary waves are observed, and they move steadily ahead of and along with the moving forcing. Finally, when the forcing speed is very close to cmin, oblique shedding phenomena of 3-D gravity-capillary solitary waves are observed ahead of the moving forcing. We found that all the linear and nonlinear wave patterns generated by the air-suction forcing correspond to those generated by the air-blowing forcing. The main difference is that 3-D gravity-capillary solitary waves are observed "ahead of" the air-suction forcing, whereas the same waves are observed "behind" the air-blowing forcing. This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2014R1A1A1002441).

  10. Observations of ionospheric ELF and VLF wave generation by excitation of the thermal cubic nonlinearity.

    PubMed

    Moore, R C; Fujimaru, S; Kotovsky, D A; Gołkowski, M

    2013-12-06

    Extremely-low-frequency (ELF, 3-3000 Hz) and very-low-frequency (VLF, 3-30 kHz) waves generated by the excitation of the thermal cubic nonlinearity are observed for the first time at the High-Frequency Active Auroral Research Program high-frequency transmitter in Gakona, Alaska. The observed ELF and VLF field amplitudes are the strongest generated by any high frequency (HF, 3-30 MHz) heating facility using this mechanism to date. This manner of ELF and VLF generation is independent of naturally forming currents, such as the auroral electrojet current system. Time-of-arrival analysis applied to experimental observations shows that the thermal cubic ELF and VLF source region is located within the collisional D-region ionosphere. Observations are compared with the predictions of a theoretical HF heating model using perturbation theory. For the experiments performed, two X-mode HF waves were transmitted at frequencies ω1 and ω2, with |ω2-2ω1| being in the ELF and VLF frequency range. In contrast with previous work, we determine that the ELF and VLF source is dominantly produced by the interaction between collision frequency oscillations at frequency ω2-ω1 and the polarization current density associated with the lower frequency HF wave at frequency ω1. This specific interaction has been neglected in past cubic thermal nonlinearity work, and it plays a major role in the generation of ELF and VLF waves.

  11. Observations of Ionospheric ELF and VLF Wave Generation by Excitation of the Thermal Cubic Nonlinearity

    NASA Astrophysics Data System (ADS)

    Moore, R. C.; Fujimaru, S.; Kotovsky, D. A.; Gołkowski, M.

    2013-12-01

    Extremely-low-frequency (ELF, 3-3000 Hz) and very-low-frequency (VLF, 3-30 kHz) waves generated by the excitation of the thermal cubic nonlinearity are observed for the first time at the High-Frequency Active Auroral Research Program high-frequency transmitter in Gakona, Alaska. The observed ELF and VLF field amplitudes are the strongest generated by any high frequency (HF, 3-30 MHz) heating facility using this mechanism to date. This manner of ELF and VLF generation is independent of naturally forming currents, such as the auroral electrojet current system. Time-of-arrival analysis applied to experimental observations shows that the thermal cubic ELF and VLF source region is located within the collisional D-region ionosphere. Observations are compared with the predictions of a theoretical HF heating model using perturbation theory. For the experiments performed, two X-mode HF waves were transmitted at frequencies ω1 and ω2, with |ω2-2ω1| being in the ELF and VLF frequency range. In contrast with previous work, we determine that the ELF and VLF source is dominantly produced by the interaction between collision frequency oscillations at frequency ω2-ω1 and the polarization current density associated with the lower frequency HF wave at frequency ω1. This specific interaction has been neglected in past cubic thermal nonlinearity work, and it plays a major role in the generation of ELF and VLF waves.

  12. Approach of virtual observations generation of a multi-reference GPS station network

    NASA Astrophysics Data System (ADS)

    Yu, Guorong

    2007-11-01

    The generation of virtual reference station observations to relay the corrections to the rover receiver for use with standard RTK software is one of important architectures of reference station networks RTK positioning. The approach of virtual observations generation based on a multi-reference GPS station network is presented in this paper. Ambiguities for the baselines in the reference network are determined firstly. The inter-reference-station differential spatially-correlated errors are estimated using highly accurate coordinates of the reference stations and resolved ambiguities. These spatially-correlated errors are interpolated among the network region as corrections. These network-generated corrections are used to correct the zero-differential observables of one reference station, which is usually the closest one to the rover (the so-called primary reference station). These corrected zero-differential observables, named virtual observations, are processed using conventional single reference station differential GPS algorithms. A test conducted using regional reference networks in Jiangsu(China) demonstrates the effectiveness of the approach to reduce the time to integer ambiguity resolution, and to increase the distance over which centimeter level accuracies can be achieved.

  13. Experiences in Applying Earth Observing Satellite Technology in SERVIR Regions with an Emphasis on Disasters: Successes, Lessons and Paths Forward

    NASA Technical Reports Server (NTRS)

    Anderson, Eric

    2017-01-01

    Earth observing satellites offer a unique perspective of our environment from the vantage point of space. Repeated measurements of the Earths subsystems such as the biosphere, atmosphere, lithosphere, hydrosphere, and of humans interactions with their environments, allow for a better understanding of Earth system processes, and they can provide input for decision making in areas of environmental management and disaster risk reduction. SERVIR is a joint initiative of the US National Aeronautics and Space Administration (NASA) and the US Agency for International Development (USAID) that began in 2005 and has been active in applying Earth observations for sustainable development in many regions around the world, recently the Lower Mekong and West Africa regions. This talk will highlight some successes achieved and lessons learned through SERVIR in Central America, Eastern Southern Africa, and the Hindu Kush-Himalaya region, focusing on disasters. We will also present opportunities for enhanced decision making with Earth observations and geospatial technologies in the Lower Mekong region.

  14. Experimental Observation of the Blob-Generation Mechanism from Interchange Waves in a Plasma

    SciTech Connect

    Furno, I.; Labit, B.; Podesta, M.; Fasoli, A.; Poli, F. M.; Ricci, P.; Theiler, C.; Brunner, S.; Diallo, A.; Graves, J.; Mueller, S. H.

    2008-02-08

    The mechanism for blob generation in a toroidal magnetized plasma is investigated using time-resolved measurements of two-dimensional structures of electron density, temperature, and plasma potential. The blobs are observed to form from a radially elongated structure that is sheared off by the ExB flow. The structure is generated by an interchange wave that increases in amplitude and extends radially in response to a decrease of the radial pressure scale length. The dependence of the blob amplitude upon the pressure radial scale length is discussed.

  15. Modeling the final phase of landfill gas generation from long-term observations.

    PubMed

    Tintner, Johannes; Kühleitner, Manfred; Binner, Erwin; Brunner, Norbert; Smidt, Ena

    2012-06-01

    For waste management, methane emissions from landfills and their effect on climate change are of serious concern. Current models for biogas generation that focus on the economic use of the landfill gas are usually based on first order chemical reactions (exponential decay), underestimating the long-term emissions of landfills. The presented study concentrated on the curve fitting and the quantification of the gas generation during the final degradation phase under optimal anaerobic conditions. For this purpose the long-term gas generation (240-1,830 days) of different mechanically biologically treated (MBT) waste materials was measured. In this study the late gas generation was modeled by a log-normal distribution curve to gather the maximum gas generation potential. According to the log-normal model the observed gas sum curve leads to higher values than commonly used exponential decay models. The prediction of the final phase of landfill gas generation by a fitting model provides a basis for CO(2) balances in waste management and some information to which extent landfills serve as carbon sink.

  16. Observational properties of dayside throat aurora and implications on the possible generation mechanisms

    NASA Astrophysics Data System (ADS)

    Han, D.-S.; Hietala, H.; Chen, X.-C.; Nishimura, Y.; Lyons, L. R.; Liu, J.-J.; Hu, H.-Q.; Yang, H.-G.

    2017-02-01

    Observational properties of throat aurora are investigated in detail by using 7 year continuous auroral observations obtained at Yellow River Station (magnetic latitude 76.24°N). From our inspection, throat aurora is often observed under the condition of stripy diffuse aurora contacting with the persistent discrete auroral oval, and the long-period throat aurora observations generally consist of intermittent subsequences of throat aurora brightening followed by poleward moving auroral form and throat aurora dimming. We also noticed that the orientation of throat aurora is aligned along the ionospheric convection flow, and its local time distribution shows clear dependence on the interplanetary magnetic field (IMF) By component. These observational results indicate that factors inside the magnetosphere may play important role on occurrence of throat aurora. We thus suggest that throat aurora may present the ionospheric signature of redistribution of reconnection rate on the magnetopause by cold magnetospheric plasma flowing into the reconnection site. In addition, we also found that the occurrence rate of throat aurora clearly decreases with increase of the IMF cone angle (arccos(|Bx|/B)), which is very similar with the occurrence rate of high-speed jet (HSJ) observed in magnetosheath depending on the IMF cone angle. This is suggested as that the HSJs occurred outside the magnetosphere may also play important role for generation of throat aurora by triggering magnetopause reconnection or by direct impacting. Although further studies are needed to clarify how the throat auroras are generated in detail, the relevant observations about throat aurora have presented important implications on a variety open questions, such as distribution and generation of cold plasma structures in the outer magnetosphere, magnetopause deformation, and possible relation between HSJ and reconnection.

  17. Prognostic variables for shockwave lithotripsy (SWL) treatment success: no impact of body mass index (BMI) using a third generation lithotripter.

    PubMed

    Hatiboglu, Gencay; Popeneciu, Valentin; Kurosch, Martin; Huber, Johannes; Pahernik, Sascha; Pfitzenmaier, Jesco; Haferkamp, Axel; Hohenfellner, Markus

    2011-10-01

    • To investigate the effect of different variables including body mass index (BMI) on therapy outcome in patients with upper urinary tract stones treated with a third generation lithotripter, as BMI has been reported to be an independent predictor for stone-free status after extracorporeal shockwave lithotripsy (SWL) performed with first or second generation lithotripters. • In all, 172 patients with kidney stones with a mean (range) size of 9.2 (3.0-32.0) mm were included in the study. • In all, 91 patients (52.9%) were treated with a ureteric stent in situ. • For SWL therapy a third generation, electromagnetic lithotripter (Siemens Lithoskop™) was used. Stone-free status was reached, when no more treatable stones were present (no stone or stone < 3 mm). • BMI, stone size and localization, age, gender, treatment parameters and ureteric stent in situ were evaluated for their prognostic relevance on therapy success. • The mean (range) BMI of all patients was 27.8 (19.0-58.6) kg/m(2). • Patients were categorized into two groups: A) patients that were stone free after one treatment; B) patients with residual stones. The mean (sd) BMI was 27.4 (4.6) kg/m(2) and 28.4 (6.1) kg/m(2) for A and B, respectively. • Univariate and multivariate analysis for freedom of stones showed that only stone size (P < 0.01) and presence of a ureteric stent (P = 0.01) were independent prognostic variables. • BMI had no significant influence on therapy outcome (P = 0.51). • Using a third generation lithotripter, BMI was not an independent predictor of stone-free rate after SWL therapy of kidney stones. • This effect might be attributed to a greater penetration depth of the shockwave energy. Stone size and a ureteric stent in situ were the only variables with prognostic significance. © 2010 THE AUTHORS. BJU INTERNATIONAL © 2010 BJU INTERNATIONAL.

  18. Making Sure They Make It! Best Practices for Ensuring the Academic Success of First-Generation College Students. CIC/Walmart College Success Awards Report

    ERIC Educational Resources Information Center

    Strand, Kerry J.

    2013-01-01

    A baccalaureate degree is essential to success in the contemporary United States. The degree offers improved economic security and the development of capabilities such as critical thinking, effective communication, quantitative reasoning, creativity, problem solving, personal and social responsibility, and social and cultural capital. Failure to…

  19. Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring.

    PubMed

    Li, Chao-Hui; Yan, Lan-Zhen; Ban, Wen-Zan; Tu, Qiu; Wu, Yong; Wang, Lin; Bi, Rui; Ji, Shuang; Ma, Yu-Hua; Nie, Wen-Hui; Lv, Long-Bao; Yao, Yong-Gang; Zhao, Xu-Dong; Zheng, Ping

    2017-02-01

    Tree shrews have a close relationship to primates and have many advantages over rodents in biomedical research. However, the lack of gene manipulation methods has hindered the wider use of this animal. Spermatogonial stem cells (SSCs) have been successfully expanded in culture to permit sophisticated gene editing in the mouse and rat. Here, we describe a culture system for the long-term expansion of tree shrew SSCs without the loss of stem cell properties. In our study, thymus cell antigen 1 was used to enrich tree shrew SSCs. RNA-sequencing analysis revealed that the Wnt/β-catenin signaling pathway was active in undifferentiated SSCs, but was downregulated upon the initiation of SSC differentiation. Exposure of tree shrew primary SSCs to recombinant Wnt3a protein during the initial passages of culture enhanced the survival of SSCs. Use of tree shrew Sertoli cells, but not mouse embryonic fibroblasts, as feeder was found to be necessary for tree shrew SSC proliferation, leading to a robust cell expansion and long-term culture. The expanded tree shrew SSCs were transfected with enhanced green fluorescent protein (EGFP)-expressing lentiviral vectors. After transplantation into sterilized adult male tree shrew's testes, the EGFP-tagged SSCs were able to restore spermatogenesis and successfully generate transgenic offspring. Moreover, these SSCs were suitable for the CRISPR/Cas9-mediated gene modification. The development of a culture system to expand tree shrew SSCs in combination with a gene editing approach paves the way for precise genome manipulation using the tree shrew.

  20. The first successful observation of in-cell NMR signals of DNA and RNA in living human cells.

    PubMed

    Yamaoki, Yudai; Kiyoishi, Ayaka; Miyake, Masayuki; Kano, Fumi; Murata, Masayuki; Nagata, Takashi; Katahira, Masato

    2017-10-12

    In order to understand intracellular biological events, information on the structure, dynamics and interaction of proteins and nucleic acids in living cells is of crucial importance. In-cell NMR is a promising method to obtain this information. Although NMR signals of proteins in human cells have been reported, those of nucleic acids were reported only in Xenopus laevis oocytes, i.e., not in human cells. Here, DNA and RNA were introduced into human cells by means of pore formation by bacterial toxin streptolysin O and subsequent resealing. Then, NMR signals of DNA and RNA were successfully observed for the first time in living human cells. The observed signals directly suggested the formation of DNA and RNA hairpin structures in living human cells.

  1. Advanced Virgo Interferometer: a Second Generation Detector for Gravitational Waves Observation

    NASA Astrophysics Data System (ADS)

    Accadia, T.; Acernese, F.; Agathos, M.; Allocca, A.; Astone, P.; Ballardin, G.; Barone, F.; Barsuglia, M.; Basti, A.; Bauer, Th. S.; Bejger, M.; Beker, M. G.; Belczynski, C.; Bersanetti, D.; Bertolini, A.; Bitossi, M.; Bizouard, M. A.; Blom, M.; Boer, M.; Bondu, F.; Bonelli, L.; Bonnand, R.; Boschi, V.; Bosi, L.; Bradaschia, C.; Branchesi, M.; Briant, T.; Brillet, A.; Brisson, V.; Bulik, T.; Bulten, H. J.; Buskulic, D.; Buy, C.; Cagnoli, G.; Calloni, E.; Canuel, B.; Carbognani, F.; Cavalier, F.; Cavalieri, R.; Cella, G.; Cesarini, E.; Chassande-Mottin, E.; Chincarini, A.; Chiummo, A.; Cleva, F.; Coccia, E.; Cohadon, P.-F.; Colla, A.; Colombini, M.; Conte, A.; Coulon, J.-P.; Cuoco, E.; D'Antonio, S.; Dattilo, V.; Davier, M.; Day, R.; Debreczeni, G.; Degallaix, J.; Deléglise, S.; Del Pozzo, W.; Dereli, H.; De Rosa, R.; di Fiore, L.; di Lieto, A.; di Virgilio, A.; Drago, M.; Endrőczi, G.; Fafone, V.; Farinon, S.; Ferrante, I.; Ferrini, F.; Fidecaro, F.; Fiori, I.; Flaminio, R.; Fournier, J.-D.; Franco, S.; Frasca, S.; Frasconi, F.; Gammaitoni, L.; Garufi, F.; Gemme, G.; Genin, E.; Gennai, A.; Giazotto, A.; Gouaty, R.; Granata, M.; Groot, P.; Guidi, G. M.; Heidmann, A.; Heitmann, H.; Hello, P.; Hemming, G.; Jaranowski, P.; Jonker, R. J. G.; Kasprzack, M.; Kéfélian, F.; Kowalska, I.; Królak, A.; Kutynia, A.; Lazzaro, C.; Leonardi, M.; Leroy, N.; Letendre, N.; Li, T. G. F.; Lorenzini, M.; Loriette, V.; Losurdo, G.; Majorana, E.; Maksimovic, I.; Malvezzi, V.; Man, N.; Mangano, V.; Mantovani, M.; Marchesoni, F.; Marion, F.; Marque, J.; Martelli, F.; Martinelli, L.; Masserot, A.; Meacher, D.; Meidam, J.; Michel, C.; Milano, L.; Minenkov, Y.; Mohan, M.; Morgado, N.; Mours, B.; Nagy, M. F.; Nardecchia, I.; Naticchioni, L.; Nelemans, G.; Neri, I.; Neri, M.; Nocera, F.; Palomba, C.; Paoletti, F.; Paoletti, R.; Pasqualetti, A.; Passaquieti, R.; Passuello, D.; Pichot, M.; Piergiovanni, F.; Pinard, L.; Poggiani, R.; Prijatelj, M.; Prodi, G. A.; Punturo, M.; Puppo, P.; Rabeling, D. S.; Rácz, I.; Rapagnani, P.; Re, V.; Regimbau, T.; Ricci, F.; Robinet, F.; Rocchi, A.; Rolland, L.; Romano, R.; Rosińska, D.; Ruggi, P.; Saracco, E.; Sassolas, B.; Sentenac, D.; Sequino, V.; Shah, S.; Siellez, K.; Sperandio, L.; Straniero, N.; Sturani, R.; Swinkels, B.; Tacca, M.; Ter Braack, A. P. M.; Toncelli, A.; Tonelli, M.; Torre, O.; Travasso, F.; Vajente, G.; van den Brand, J. F. J.; van den Broeck, C.; van der Putten, S.; van der Sluys, M. V.; van Heijningen, J.; Vasúth, M.; Vedovato, G.; Veitch, J.; Verkindt, D.; Vetrano, F.; Viceré, A.; Vinet, J.-Y.; Vitale, S.; Vocca, H.; Wei, L.-W.; Yvert, M.; Zadrożny, A.; Zendri, J.-P.

    2015-03-01

    In the last ten years great improvements have been done in the development and operation of ground based detectors for Gravitational Waves direct observation and study. The second generation detectors are presently under construction in Italy, United States and Japan with a common intent to create a worldwide network of instruments able to start a new era in astronomy and astrophysics, a century after the development of the General Relativity theory predicting the existence of Gravitational Waves. The design sensitivity of the advanced detectors will be approximately ten times better with respect to the previous generation corresponding to an increment of a factor one thousand in the observational volume of the Universe where black holes, neutron stars and other enigmatic sources of these weak signals are spread around. In this paper we present a general overview of the advanced detectors with particular emphasis on Advanced VIRGO, the largest European interferometer located at the European Gravitational Observatory (EGO) site in the Pisa countryside (Italy).

  2. Experimental observation of cumulative second-harmonic generation of lamb waves propagating in long bones.

    PubMed

    Zhang, Zhenggang; Liu, Dan; Deng, Mingxi; Ta, Dean; Wang, Weiqi

    2014-07-01

    The experimental observation of cumulative second-harmonic generation of fundamental Lamb waves in long bones is reported. Based on the modal expansion approach to waveguide excitation and the dispersion characteristics of Lamb waves in long bones, the mechanism underlying the generation and accumulation of second harmonics by propagation of the fundamental Lamb waves was investigated. An experimental setup was established to detect the second-harmonic signals of Lamb wave propagation in long bones in vitro. Through analysis of the group velocities of the received signals, the appropriate fundamental Lamb wave modes and the duration of the second-harmonic signals could be identified. The integrated amplitude of the time-domain second-harmonic signal was introduced and used to characterize the efficiency of second-harmonic generation by fundamental Lamb wave propagation. The results indicate that the second-harmonic signal generated by fundamental Lamb waves propagating in long bones can be observed clearly, and the effect was cumulative with propagation distance when the fundamental Lamb wave mode and the double-frequency Lamb wave mode had the same phase velocities. The present results may be important in the development of a new method to evaluate the status of long bones using the cumulative second harmonic of ultrasonic Lamb waves.

  3. Gravity Waves Generated by Convection: A New Idealized Model Tool and Direct Validation with Satellite Observations

    NASA Astrophysics Data System (ADS)

    Alexander, M. Joan; Stephan, Claudia

    2015-04-01

    In climate models, gravity waves remain too poorly resolved to be directly modelled. Instead, simplified parameterizations are used to include gravity wave effects on model winds. A few climate models link some of the parameterized waves to convective sources, providing a mechanism for feedback between changes in convection and gravity wave-driven changes in circulation in the tropics and above high-latitude storms. These convective wave parameterizations are based on limited case studies with cloud-resolving models, but they are poorly constrained by observational validation, and tuning parameters have large uncertainties. Our new work distills results from complex, full-physics cloud-resolving model studies to essential variables for gravity wave generation. We use the Weather Research Forecast (WRF) model to study relationships between precipitation, latent heating/cooling and other cloud properties to the spectrum of gravity wave momentum flux above midlatitude storm systems. Results show the gravity wave spectrum is surprisingly insensitive to the representation of microphysics in WRF. This is good news for use of these models for gravity wave parameterization development since microphysical properties are a key uncertainty. We further use the full-physics cloud-resolving model as a tool to directly link observed precipitation variability to gravity wave generation. We show that waves in an idealized model forced with radar-observed precipitation can quantitatively reproduce instantaneous satellite-observed features of the gravity wave field above storms, which is a powerful validation of our understanding of waves generated by convection. The idealized model directly links observations of surface precipitation to observed waves in the stratosphere, and the simplicity of the model permits deep/large-area domains for studies of wave-mean flow interactions. This unique validated model tool permits quantitative studies of gravity wave driving of regional

  4. Kilometric radio waves generated along auroral field lines observed by ground facilities - A theoretical model

    NASA Technical Reports Server (NTRS)

    Ziebell, L. F.; Wu, C. S.; Yoon, Peter H.

    1991-01-01

    A theory of generation of radio waves observed by ground-based facilities in the frequency range 150-700 kHz is discussed. This work is a continuation of an earlier discussion (Wu et al., 1989) in which it was proposed that the trapped electrons along the auroral field lines can lead to a cyclotron instability which amplifies the whistler waves observed at ground level. The objective of the present study is to investigate the propagation effect on the wave amplification and to examine whether the proposed mechanism is indeed viable.

  5. Kilometric radio waves generated along auroral field lines observed by ground facilities - A theoretical model

    NASA Technical Reports Server (NTRS)

    Ziebell, L. F.; Wu, C. S.; Yoon, Peter H.

    1991-01-01

    A theory of generation of radio waves observed by ground-based facilities in the frequency range 150-700 kHz is discussed. This work is a continuation of an earlier discussion (Wu et al., 1989) in which it was proposed that the trapped electrons along the auroral field lines can lead to a cyclotron instability which amplifies the whistler waves observed at ground level. The objective of the present study is to investigate the propagation effect on the wave amplification and to examine whether the proposed mechanism is indeed viable.

  6. Observational evidence of generation mechanisms for very oblique lower band chorus using THEMIS waveform data

    NASA Astrophysics Data System (ADS)

    Gao, Xinliang; Mourenas, Didier; Li, Wen; Artemyev, Anton V.; Lu, Quanming; Tao, Xin; Wang, Shui

    2016-07-01

    Chorus waves are intense coherent whistler mode waves with frequency chirping which play a dual role in both loss and acceleration of radiation belt electrons in the Earth's magnetosphere. Although the generation of parallel chorus waves has been extensively studied by means of theory, simulations, and observations, the generation mechanism of very oblique chorus waves still remains a mystery. In this study, we have analyzed hundreds of very oblique discrete (rising or falling tone) lower band chorus events collected from 7 years of Time History of Events and Macroscale Interactions during Substorms (THEMIS) waveform data to investigate their potential generation mechanisms. Comparisons between wave normal angles directly measured onboard THEMIS in the dawn-day sector at L = 5-9 and inferred from theoretical models on the basis of measured wave characteristics (frequency sweep rate, mean frequency, and amplitude) show that these very oblique waves are more commonly generated through cyclotron resonance with anisotropic electron streams. However, a second generation mechanism via Landau resonance with low-energy electron beams seems to be also operating on the nightside at L < 6.7 and at all local times at L > 8.5. Moreover, very oblique lower band chorus waves with large frequency chirping rates or small magnetic field amplitudes are more likely excited via cyclotron resonance, while waves with small frequency chirping rates or large magnetic field amplitudes are preferentially generated through Landau resonance. This comprehensive statistical study provides interesting insight into the possible generation mechanisms of very oblique lower band chorus waves in the Earth's magnetosphere.

  7. The predicted and observed decline in onchocerciasis infection during 14 years of successful control of Simulium spp. in west Africa.

    PubMed Central

    Remme, J.; De Sole, G.; van Oortmarssen, G. J.

    1990-01-01

    In 55 villages from the well-protected central area of the Onchocerciasis Control Programme in West Africa (OCP), skin snip surveys have been carried out at regular intervals since the programme started, and the latest round of surveys was undertaken after 12-14 years of successful vector control. The observed trends in the prevalence and intensity of onchocerciasis infection in cohorts of adults were compared with the trends predicted using a host-parasite model. After 12-14 years of control the community microfilarial load (CMFL) was close to zero in all villages. During the last few years of control, the prevalence of infection declined at an accelerated rate, and this was predicted by the model. There was generally good agreement between observed and predicted trends. The predictions were based on an estimated average duration of infection of 10.4 years, which corresponds to a mean reproductive lifespan for Onchocerca volvulus of 9-9.5 years, and an upper limit of 15 years for 95% of the infections. Differences between the observed and predicted data included the trend in CMFL between the first and second surveys, which in 18 villages did not show the predicted decline. Furthermore, the observed final decline in prevalence was faster than predicted in the north-eastern part of the central OCP area. After 14 years of vector control, the level of onchocerciasis has fallen to such a low level that consideration is being given to ending larviciding. PMID:2393979

  8. Photochemically Generated Thiyl Free Radicals Observed by X-ray Absorption Spectroscopy

    DOE PAGES

    Sneeden, Eileen Y.; Hackett, Mark J.; Cotelesage, Julien J. H.; ...

    2017-07-27

    Sulfur-based thiyl radicals are known to be involved in a wide range of chemical and biological processes, but they are often highly reactive, which makes them difficult to observe directly. We report herein X-ray absorption spectra and analysis that support the direct observation of two different thiyl species generated photochemically by X-ray irradiation. The thiyl radical sulfur K-edge X-ray absorption spectra of both species are characterized by a uniquely low energy transition at about 2465 eV, which occurs at a lower energy than any previously observed feature at the sulfur K-edge and corresponds to a 1s → 3p transition tomore » the singly occupied molecular orbital of the free radical. In conclusion, our results constitute the first observation of substantial levels of thiyl radicals generated by X-ray irradiation and detected by sulfur K-edge X-ray absorption spectroscopy.« less

  9. Observations and Numerical Modeling of Eddy Generation in the Mediterranean Undercurrent

    NASA Astrophysics Data System (ADS)

    Serra, N.; Ambar, I.; Kaese, R.

    2001-12-01

    In the frame of the European Union MAST III project CANIGO (Canary Islands Gibraltar Azores Observations), RAFOS floats were deployed in the Mediterranean undercurrent off south Portugal during the period from September 1997 to September 1998. An analysis of this Lagrangian approach complemented with results obtained with XBT probes and current meter data from the same project shows some of the major aspects of the flow associated with the undercurrent as well as the eddy activity related with it. Floats that stayed in the undercurrent featured a downstream deceleration and a steering by bottom topography. Three meddy formations at Cape St. Vincent could be isolated from the float data as well as the generation of dipolar structures in the Portimao Canyon, a feature not previously directly observed. The dynamical coupling of meddies and cyclones was observed for a considerable period of time. High-resolution modeling of the Mediterranean Outflow using a sigma-coordinate primitive equations ocean model (SCRUM) incorporating realistic topography and stratification reveals the adjustment of the salty plume while descending along the continental slope of the Gulf of Cadiz channeled by the topography. The model reproduces the generation of eddies in the two observed sites (cape and canyon) and the splitting of the outflow water into well-defined cores.

  10. Using a micro-level model to generate a macro-level model of productive successful aging.

    PubMed

    Johnson, Jessica K M; Sarkisian, Natalia; Williamson, John B

    2015-02-01

    Aging successfully entails good physical and cognitive health, as well as ongoing participation in social and productive activity. This study hones in on participation in productive activity, a factor that makes an important contribution to successful aging. One conceptual model of productive activity in later life specifies the antecedents and consequences of productivity. This study draws on that micro-level model to develop a corresponding macro-level model and assesses its utility for examining the predictors of and explaining the relationships between one form of productivity (labor force participation rates) and one aspect of well-being (average life expectancy) among males and females. Random effects regression models and path analysis were used to analyze cross-national longitudinal data for 24 high-income Organization for Economic Co-operation and Development (OECD) countries at seven time points (1980-2010; 168 observations total). OECD countries with higher labor force participation rates among older workers have higher life expectancies. Labor force participation mediates the effects of gross domestic product per capita on male and female life expectancy, and it mediates the effect of self-employment rate for men, but it acts as a suppressor with regard to the effect of public spending on male and female life expectancy. A well-known micro-level model of productive activity can be fruitfully adapted to account for macro-level cross-national variation in productivity and well-being. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  11. Observation and Simulation of Chorus Waves Generation at the Gradients of Magnetic Holes

    NASA Astrophysics Data System (ADS)

    Ahmadi, N.; Argall, M. R.; Paulson, K. W.; Ergun, R.; Wilder, F. D.; Germaschewski, K.; Khotyaintsev, Y. V.; Torbert, R. B.; Russell, C. T.; Strangeway, R. J.; Magnes, W.; Le Contel, O.; Giles, B. L.

    2016-12-01

    The Magnetospheric Multiscale (MMS) mission observed chorus waves at the gradients of magnetic holes on the dayside magnetosheath. The magnetic holes are nonlinear mirror structures which are anticorrelated with particle density. We used expanding box Particle-in-cell simulations and produced the mirror instability magnetic holes. We show that chorus waves are generated at the gradients of magnetic holes in our simulations which is in agreement with MMS observations. We investigate the possible mechanism for enhancing the electron temperature anisotropy at the magnetic field gradients. We analyze the electron pitch angle distributions and electron distribution functions in our simulations and compare it with MMS observations. We also measure the Poynting flux to investigate how much energy is carried away by the fields via chorus waves.

  12. Successful outcomes with oral fluoroquinolones combined with rifampicin in the treatment of Mycobacterium ulcerans: an observational cohort study.

    PubMed

    O'Brien, Daniel P; McDonald, Anthony; Callan, Peter; Robson, Mike; Friedman, N Deborah; Hughes, Andrew; Holten, Ian; Walton, Aaron; Athan, Eugene

    2012-01-01

    The World Health Organization currently recommends combined streptomycin and rifampicin antibiotic treatment as first-line therapy for Mycobacterium ulcerans infections. Alternatives are needed when these are not tolerated or accepted by patients, contraindicated, or neither accessible nor affordable. Despite in vitro effectiveness, clinical evidence for fluoroquinolone antibiotic use against Mycobacterium ulcerans is lacking. We describe outcomes and tolerability of fluoroquinolone-containing antibiotic regimens for Mycobacterium ulcerans in south-eastern Australia. Analysis was performed of prospectively collected data including all primary Mycobacterium ulcerans infections treated at Barwon Health between 1998 and 2010. Medical treatment involved antibiotic use for more than 7 days; surgical treatment involved surgical excision of a lesion. Treatment success was defined as complete lesion healing without recurrence at 12 months follow-up. A complication was defined as an adverse event attributed to an antibiotic that required its cessation. A total of 133 patients with 137 lesions were studied. Median age was 62 years (range 3-94 years). 47 (34%) had surgical treatment alone, and 90 (66%) had combined surgical and medical treatment. Rifampicin and ciprofloxacin comprised 61% and rifampicin and clarithromycin 23% of first-line antibiotic regimens. 13/47 (30%) treated with surgery alone failed treatment compared to 0/90 (0%) of those treated with combination medical and surgical treatment (p<0.0001). There was no difference in treatment success rate for antibiotic combinations containing a fluoroquinolone (61/61 cases; 100%) compared with those not containing a fluoroquinolone (29/29 cases; 100%). Complication rates were similar between ciprofloxacin and rifampicin (31%) and rifampicin and clarithromycin (33%) regimens (OR 0.89, 95% CI 0.27-2.99). Paradoxical reactions during treatment were observed in 8 (9%) of antibiotic treated cases. Antibiotics combined with

  13. Observations concerning the generation and propagation of Type III solar bursts

    NASA Technical Reports Server (NTRS)

    Kellogg, P. J.

    1986-01-01

    A number of Type III bursts were observed during the Helios missions in which the burst exciter passed over the spacecraft, as evidenced by strong electric field fluctuations near the plasma frequency. Six of these were suitable for detailed study. Of the six events, one was ambiguous, one showed what is interpreted as a switchover from harmonic to fundamental, and the rest all generated fundamental at onset. This would be expected if both fundamental and harmonic are generated, as, at a fixed frequency, the fundamental will be generated earlier. For the event which seems to show both fundamental and harmonic emission, the frequency ratio is not exactly 2. This is explained in terms of a time delay of the fundamental, due to scattering and diffusion in the source region. A time delay of the order of 600 seconds at 1 AU and 20 kHz, and inversely proportional to frequency, is required to explain the observations. Crude estimates show that delay times at least this long may be attributed to trapping and scattering.

  14. Real-time observation of interfering crystal electrons in high-harmonic generation.

    PubMed

    Hohenleutner, M; Langer, F; Schubert, O; Knorr, M; Huttner, U; Koch, S W; Kira, M; Huber, R

    2015-07-30

    Acceleration and collision of particles has been a key strategy for exploring the texture of matter. Strong light waves can control and recollide electronic wavepackets, generating high-harmonic radiation that encodes the structure and dynamics of atoms and molecules and lays the foundations of attosecond science. The recent discovery of high-harmonic generation in bulk solids combines the idea of ultrafast acceleration with complex condensed matter systems, and provides hope for compact solid-state attosecond sources and electronics at optical frequencies. Yet the underlying quantum motion has not so far been observable in real time. Here we study high-harmonic generation in a bulk solid directly in the time domain, and reveal a new kind of strong-field excitation in the crystal. Unlike established atomic sources, our solid emits high-harmonic radiation as a sequence of subcycle bursts that coincide temporally with the field crests of one polarity of the driving terahertz waveform. We show that these features are characteristic of a non-perturbative quantum interference process that involves electrons from multiple valence bands. These results identify key mechanisms for future solid-state attosecond sources and next-generation light-wave electronics. The new quantum interference process justifies the hope for all-optical band-structure reconstruction and lays the foundation for possible quantum logic operations at optical clock rates.

  15. Characteristics of cyclone generated gravity waves observed using assimilated WRF model simulations over Bay of Bengal

    NASA Astrophysics Data System (ADS)

    Hima Bindu, H.; Venkat Ratnam, M.; Yesubabu, V.; Narayana Rao, T.; Kesarkar, Amit; Naidu, C. V.

    2016-11-01

    Characteristics of gravity waves (GWs) generated due to tropical cyclone (TC) Phailin (2013) that occurred over Bay of Bengal are investigated using the Weather Research and Forecast (WRF) model simulations from its depression stage to weakening stage (10-14 October 2013). Two types of numerical experiments are conducted with and without assimilating conventional and satellite observations using the 3-Dimentional Variational (3DVAR) technique. The results show that the experiment without assimilating any observations (control) has produced a large difference in terms of track and intensity with observed best track estimates of IMD. Similar features are noticed also in winds, reflectivity and independent GPS Radio Occultation (temperature) and radiosonde (temperature and winds) profiles. The experiment with assimilation significantly reduced the observed differences in all the above mentioned parameters. A close match of the assimilated outputs with observations prompted us to use it to identify the TC generated GW characteristics. GW perturbation components are extracted from the three day mean (4-7 October 2013) calm background atmosphere prior to the formation of depression. When compared to the control run, assimilated outputs show a clear increase in all the gravity wave parameters except the amplitudes where control run wave amplitudes are found to be stronger than the assimilated outputs. Fast Fourier transform (FFT) analysis in the time domain revealed dominance of GWs with periods of 2-4 h. Band pass filtered vertical velocity perturbations for these periods showed clear downward phase propagation (0.05-0.07 ms- 1) in the upper troposphere and lower stratosphere (UTLS) at different latitude/longitude positions away from the centre of the TC revealing an upward energy propagation of generated GWs. Interestingly, an increase in GW activity during the landfall of the TC is found. FFT in the vertical domain revealed vertical wavelengths ranging from 3 to 8 km

  16. Electrostatic Swelling and Conformational Variation Observed in High-Generation Polyelectrolyte Dendrimers

    SciTech Connect

    Butler, Paul D; Chen, Wei-Ren; Herwig, Kenneth W; Hong, Kunlun; Liu, Yun; Porcar, L.; Shew, Chwen-Yang; Smith, Gregory Scott; Chen, Hsin-Lung; Chen, Chun-Yu; Li, Xin; Liu, Emily

    2010-01-01

    A coordinated study combining small angle neutron scattering (SANS) and small angle x-ray scattering (SAXS) measurements was conducted to investigate the structural characteristics of aqueous (D2O) generation 7 and 8 (G7 & G8) PAMAM dendrimer solutions as a function of molecular protonation at room temperature. The change in intra-molecular conformation was clearly exhibited in the data analysis by separating the variation in the inter-molecular correlation. Our results unambiguously demonstrate an increased molecular size and evolved intra-molecular density profile upon increasing the molecular protonation. This is contrary to the existing understanding that in higher generation polyelectrolyte dendrimers, steric crowding stiffens the local motion of dendrimer segments exploring additional available intra-dendrimer volume and therefore inhibits the electrostatic swelling. Our observation is relevant to elucidation of the general microscopic picture of polyelectrolyte dendrimer structure, as well as the development of dendrimer-based packages with based on the stimuli-responsive principle.

  17. Internal Tide Generation, Propagation and Transformation north of Pt. Conception, CA: Observations and Model Simulations

    NASA Astrophysics Data System (ADS)

    Kumar, N.; Suanda, S. H.; Colosi, J. A.; Cai, D.; Haas, K. A.; Di Lorenzo, E.; Edwards, C. A.; Miller, A. J.; Feddersen, F.

    2016-12-01

    The inner- to outer-shelf region of Santa Maria Basin, north of Point Conception, CA is subjected to strong semi-diurnal internal-tidal variability, with implications for cross-shore tracer exchange. The generation hot-spots, and pathways for propagation of internal tides to this region is unknown, and is investigated through a set of realistic, one-way nested, hydrostatic numerical ocean model (ROMS) simulations. Modeled temperature and velocity variability are compared to mid-shelf observations adjacent to Point Sal, CA, and compare well. Modeled semi-diurnal barotropic to baroclinic conversion occurs at multiple locations along the Santa-Rosa Cortes Ridge at water depths of 1000-2000 m. The modeled, depth-integrated, baroclinic energy fluxes originate from the generation region, are directed towards the Santa Maria basin, and agree well with observed energy fluxes at 50 and 30 m water depth. The baroclinic tidal energy balance terms separated into coherent (phase locked to M2, S2 and N2) and incoherent terms. Energy fluxes are strongly coherent over the generation region, while in the shelf region incoherent and coherent energy fluxes are of similar magnitude. The increase in incoherent energy fluxes occur within 4 internal-tidal wavelengths. Modeled mid-water column temperature spectra is narrow-banded at the generation region, however, on propagation to shallower waters, the temperature spectra broadens indicating energy transfer to lower and higher-frequencies potentially due to interaction with meso- and submesoscale processes with velocities up to 40% of the first mode internal tidal phase speed. Finally, the length scales of modeled incoherent semi-diurnal baroclinic energy (10 km) are one order of magnitude smaller than those for coherent energy. Funded by the Office of Naval Research.

  18. Observed 3D Structure, Generation, and Dissipation of Oceanic Mesoscale Eddies in the South China Sea

    PubMed Central

    Zhang, Zhiwei; Tian, Jiwei; Qiu, Bo; Zhao, Wei; Chang, Ping; Wu, Dexing; Wan, Xiuquan

    2016-01-01

    Oceanic mesoscale eddies with horizontal scales of 50–300 km are the most energetic form of flows in the ocean. They are the oceanic analogues of atmospheric storms and are effective transporters of heat, nutrients, dissolved carbon, and other biochemical materials in the ocean. Although oceanic eddies have been ubiquitously observed in the world oceans since 1960s, our understanding of their three-dimensional (3D) structure, generation, and dissipation remains fragmentary due to lack of systematic full water-depth measurements. To bridge this knowledge gap, we designed and conducted a multi-months field campaign, called the South China Sea Mesoscale Eddy Experiment (S-MEE), in the northern South China Sea in 2013/2014. The S-MEE for the first time captured full-depth 3D structures of an anticyclonic and cyclonic eddy pair, which are characterized by a distinct vertical tilt of their axes. By observing the eddy evolution at an upstream versus downstream location and conducting an eddy energy budget analysis, the authors further proposed that generation of submesoscale motions most likely constitutes the dominant dissipation mechanism for the observed eddies. PMID:27074710

  19. Observed 3D Structure, Generation, and Dissipation of Oceanic Mesoscale Eddies in the South China Sea

    NASA Astrophysics Data System (ADS)

    Zhang, Zhiwei; Tian, Jiwei; Qiu, Bo; Zhao, Wei; Chang, Ping; Wu, Dexing; Wan, Xiuquan

    2016-04-01

    Oceanic mesoscale eddies with horizontal scales of 50–300 km are the most energetic form of flows in the ocean. They are the oceanic analogues of atmospheric storms and are effective transporters of heat, nutrients, dissolved carbon, and other biochemical materials in the ocean. Although oceanic eddies have been ubiquitously observed in the world oceans since 1960s, our understanding of their three-dimensional (3D) structure, generation, and dissipation remains fragmentary due to lack of systematic full water-depth measurements. To bridge this knowledge gap, we designed and conducted a multi-months field campaign, called the South China Sea Mesoscale Eddy Experiment (S-MEE), in the northern South China Sea in 2013/2014. The S-MEE for the first time captured full-depth 3D structures of an anticyclonic and cyclonic eddy pair, which are characterized by a distinct vertical tilt of their axes. By observing the eddy evolution at an upstream versus downstream location and conducting an eddy energy budget analysis, the authors further proposed that generation of submesoscale motions most likely constitutes the dominant dissipation mechanism for the observed eddies.

  20. Observed 3D Structure, Generation, and Dissipation of Oceanic Mesoscale Eddies in the South China Sea.

    PubMed

    Zhang, Zhiwei; Tian, Jiwei; Qiu, Bo; Zhao, Wei; Chang, Ping; Wu, Dexing; Wan, Xiuquan

    2016-04-14

    Oceanic mesoscale eddies with horizontal scales of 50-300 km are the most energetic form of flows in the ocean. They are the oceanic analogues of atmospheric storms and are effective transporters of heat, nutrients, dissolved carbon, and other biochemical materials in the ocean. Although oceanic eddies have been ubiquitously observed in the world oceans since 1960s, our understanding of their three-dimensional (3D) structure, generation, and dissipation remains fragmentary due to lack of systematic full water-depth measurements. To bridge this knowledge gap, we designed and conducted a multi-months field campaign, called the South China Sea Mesoscale Eddy Experiment (S-MEE), in the northern South China Sea in 2013/2014. The S-MEE for the first time captured full-depth 3D structures of an anticyclonic and cyclonic eddy pair, which are characterized by a distinct vertical tilt of their axes. By observing the eddy evolution at an upstream versus downstream location and conducting an eddy energy budget analysis, the authors further proposed that generation of submesoscale motions most likely constitutes the dominant dissipation mechanism for the observed eddies.

  1. Optical observation of metal jet generated by high speed inclined collision

    NASA Astrophysics Data System (ADS)

    Mori, A.; Tanaka, S.; Hokamoto, K.

    2017-02-01

    Explosive welding, one of the high energy rate material processing, is known the technique to weld strongly for the dissimilar metal combinations. When a metal is collided to the other metal at high velocity with a certain angle, good welding is achieved in this technique. Important parameters of the explosive welding method are the collision velocity and the collision angle. And it is necessary to know these parameters to obtain the explosively welded materials of several metals combinations. However, the optical observation for the collision of metal plate accelerated by the explosive is difficult because of the obstruction by the spreading of detonation gas. In the present work a single-stage powder gun and high speed video camera were used to observe the inclined collision of metals at the high velocity. Projectile consisted by a metal disc and sabot was accelerated by the deflagration of a gunpowder and was collided to another metal disc set with a certain angle. Metal jet was generated at the collision point when the projectile was collided to the target disc in the range of suitable conditions. By using this observation system, a series of the flow from the high speed collision to the generation of metal jet could be taken photographs clearly. This investigation shows the experimental results of the similar and dissimilar metal collision, with comparing the visualization of a metal jet simulated numerically.

  2. Second Generation Reusable Launch Vehicle Development and Global Competitiveness of US Space Transportation Industry: Critical Success Factors Assessment

    NASA Technical Reports Server (NTRS)

    Enyinda, Chris I.

    2002-01-01

    In response to the unrelenting call in both public and private sectors fora to reduce the high cost associated with space transportation, many innovative partially or fully RLV (Reusable Launch Vehicles) designs (X-34-37) were initiated. This call is directed at all levels of space missions including scientific, military, and commercial and all aspects of the missions such as nonrecurring development, manufacture, launch, and operations. According to Wertz, tbr over thirty years, the cost of space access has remained exceedingly high. The consensus in the popular press is that to decrease the current astronomical cost of access to space, more safer, reliable, and economically viable second generation RLVs (SGRLV) must be developed. Countries such as Brazil, India, Japan, and Israel are now gearing up to enter the global launch market with their own commercial space launch vehicles. NASA and the US space launch industry cannot afford to lag behind. Developing SGRLVs will immeasurably improve the US's space transportation capabilities by helping the US to regain the global commercial space markets while supporting the transportation capabilities of NASA's space missions, Developing the SGRLVs will provide affordable commercial space transportation that will assure the competitiveness of the US commercial space transportation industry in the 21st century. Commercial space launch systems are having difficulty obtaining financing because of the high cost and risk involved. Access to key financial markets is necessary for commercial space ventures. However, public sector programs in the form of tax incentives and credits, as well as loan guarantees are not yet available. The purpose of this paper is to stimulate discussion and assess the critical success factors germane for RLVs development and US global competitiveness.

  3. Second Generation Reusable Launch Vehicle Development and Global Competitiveness of US Space Transportation Industry: Critical Success Factors Assessment

    NASA Technical Reports Server (NTRS)

    Enyinda, Chris I.

    2002-01-01

    In response to the unrelenting call in both public and private sectors fora to reduce the high cost associated with space transportation, many innovative partially or fully RLV (Reusable Launch Vehicles) designs (X-34-37) were initiated. This call is directed at all levels of space missions including scientific, military, and commercial and all aspects of the missions such as nonrecurring development, manufacture, launch, and operations. According to Wertz, tbr over thirty years, the cost of space access has remained exceedingly high. The consensus in the popular press is that to decrease the current astronomical cost of access to space, more safer, reliable, and economically viable second generation RLVs (SGRLV) must be developed. Countries such as Brazil, India, Japan, and Israel are now gearing up to enter the global launch market with their own commercial space launch vehicles. NASA and the US space launch industry cannot afford to lag behind. Developing SGRLVs will immeasurably improve the US's space transportation capabilities by helping the US to regain the global commercial space markets while supporting the transportation capabilities of NASA's space missions, Developing the SGRLVs will provide affordable commercial space transportation that will assure the competitiveness of the US commercial space transportation industry in the 21st century. Commercial space launch systems are having difficulty obtaining financing because of the high cost and risk involved. Access to key financial markets is necessary for commercial space ventures. However, public sector programs in the form of tax incentives and credits, as well as loan guarantees are not yet available. The purpose of this paper is to stimulate discussion and assess the critical success factors germane for RLVs development and US global competitiveness.

  4. Response selection in dual task paradigms: observations from random generation tasks.

    PubMed

    Dirnberger, Georg; Jahanshahi, Marjan

    2010-03-01

    Performance of attention-demanding tasks is worse if two tasks are carried out simultaneously than if each of the tasks is performed alone. Our aim was to determine whether these 'dual task costs' can be attributed to mechanisms on a supra-trial level such as switching of limited resources between trials or concurrent breakdown of supervisory functions, or to mechanisms effective within each trial such as demands of response selection. Twenty healthy volunteers performed verbal random number generation (RNG) and random movement generation (RMG) at three different rates. For each rate, both tasks were examined once in a single task condition and once in a dual task condition. Results showed that performance (quality of randomness) in each random generation task (RNG/RMG) was reduced at faster rates and impaired by concurrent performance of a secondary random generation task. In the dual task condition, transient increase or decrease of bias in one random generation task during any short interval was not associated with concurrent increase or decrease of bias in the other task. In conclusion, the fact that during dual task performance transient bias in one task was not associated with concurrent improvement of performance in the other task indicates that alternation of supervisory control or attentional resources from one to the other task does not mediate the observed dual task costs. Resources of the central executive are not re-allocated or 'switched' from one to the other task. Dual task costs may result from mechanisms effective within each trial such as the demands of response selection.

  5. Sound measurements and observations of the MOD-OA wind turbine generator

    NASA Astrophysics Data System (ADS)

    Shepherd, K. P.; Hubbard, H. H.

    1982-02-01

    Sound measurements are reported for a wind velocity of about 5 m/s and a power output of about 70 kW. Both broadband and narrowband data were obtained for a range of distances and azimuth angles from the machine. Both discrete frequency and broadband components were identified. Loading harmonics at multiples of the blade passage frequency and electrical generator harmonics at multiples of the shaft speed dominated the spectrum below 100 Hz. The 10,000 Hz peak is believed to be of mechanical origin in the nacelle and the other arises from blade aerodynamic sources. Aural detection distances of about 525 m upwind and 850 downwind were observed.

  6. Sound measurements and observations of the MOD-OA wind turbine generator

    NASA Technical Reports Server (NTRS)

    Shepherd, K. P.; Hubbard, H. H.

    1982-01-01

    Sound measurements are reported for a wind velocity of about 5 m/s and a power output of about 70 kW. Both broadband and narrowband data were obtained for a range of distances and azimuth angles from the machine. Both discrete frequency and broadband components were identified. Loading harmonics at multiples of the blade passage frequency and electrical generator harmonics at multiples of the shaft speed dominated the spectrum below 100 Hz. The 10,000 Hz peak is believed to be of mechanical origin in the nacelle and the other arises from blade aerodynamic sources. Aural detection distances of about 525 m upwind and 850 downwind were observed.

  7. Deciding on success criteria for predictability of pharmacokinetic parameters from in vitro studies: an analysis based on in vivo observations.

    PubMed

    Abduljalil, Khaled; Cain, Theresa; Humphries, Helen; Rostami-Hodjegan, Amin

    2014-09-01

    Prediction accuracy of pharmacokinetic parameters is often assessed using prediction fold error, i.e., being within 2-, 3-, or n-fold of observed values. However, published studies disagree on which fold error represents an accurate prediction. In addition, "observed data" from only one clinical study are often used as the gold standard for in vitro to in vivo extrapolation (IVIVE) studies, despite data being subject to significant interstudy variability and subjective selection from various available reports. The current study involved analysis of published systemic clearance (CL) and volume of distribution at steady state (Vss) values taken from over 200 clinical studies. These parameters were obtained for 17 different drugs after intravenous administration. Data were analyzed with emphasis on the appropriateness to use a parameter value from one particular clinical study to judge the performance of IVIVE and the ability of CL and Vss values obtained from one clinical study to "predict" the same values obtained in a different clinical study using the n-fold criteria for prediction accuracy. The twofold criteria method was of interest because it is widely used in IVIVE predictions. The analysis shows that in some cases the twofold criteria method is an unreasonable expectation when the observed data are obtained from studies with small sample size. A more reasonable approach would allow prediction criteria to include clinical study information such as sample size and the variance of the parameter of interest. A method is proposed that allows the "success" criteria to be linked to the measure of variation in the observed value. Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics.

  8. Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor.

    PubMed

    Hirose, Tomoyasu; Maita, Nobuo; Gouda, Hiroaki; Koseki, Jun; Yamamoto, Tsuyoshi; Sugawara, Akihiro; Nakano, Hirofumi; Hirono, Shuichi; Shiomi, Kazuro; Watanabe, Takeshi; Taniguchi, Hisaaki; Sharpless, K Barry; Omura, Satoshi; Sunazuka, Toshiaki

    2013-10-01

    The Huisgen cycloaddition of azides and alkynes, accelerated by target biomolecules, termed "in situ click chemistry," has been successfully exploited to discover highly potent enzyme inhibitors. We have previously reported a specific Serratia marcescens chitinase B (SmChiB)-templated syn-triazole inhibitor generated in situ from an azide-bearing inhibitor and an alkyne fragment. Several in situ click chemistry studies have been reported. Although some mechanistic evidence has been obtained, such as X-ray analysis of [protein]-["click ligand"] complexes, indicating that proteins act as both mold and template between unique pairs of azide and alkyne fragments, to date, observations have been based solely on "postclick" structural information. Here, we describe crystal structures of SmChiB complexed with an azide ligand and an O-allyl oxime fragment as a mimic of a click partner, revealing a mechanism for accelerating syn-triazole formation, which allows generation of its own distinct inhibitor. We have also performed density functional theory calculations based on the X-ray structure to explore the acceleration of the Huisgen cycloaddition by SmChiB. The density functional theory calculations reasonably support that SmChiB plays a role by the cage effect during the pretranslation and posttranslation states of selective syn-triazole click formation.

  9. Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor

    PubMed Central

    Hirose, Tomoyasu; Maita, Nobuo; Gouda, Hiroaki; Koseki, Jun; Yamamoto, Tsuyoshi; Sugawara, Akihiro; Nakano, Hirofumi; Hirono, Shuichi; Shiomi, Kazuro; Watanabe, Takeshi; Taniguchi, Hisaaki; Sharpless, K. Barry; Ōmura, Satoshi; Sunazuka, Toshiaki

    2013-01-01

    The Huisgen cycloaddition of azides and alkynes, accelerated by target biomolecules, termed “in situ click chemistry,” has been successfully exploited to discover highly potent enzyme inhibitors. We have previously reported a specific Serratia marcescens chitinase B (SmChiB)-templated syn-triazole inhibitor generated in situ from an azide-bearing inhibitor and an alkyne fragment. Several in situ click chemistry studies have been reported. Although some mechanistic evidence has been obtained, such as X-ray analysis of [protein]–[“click ligand”] complexes, indicating that proteins act as both mold and template between unique pairs of azide and alkyne fragments, to date, observations have been based solely on “postclick” structural information. Here, we describe crystal structures of SmChiB complexed with an azide ligand and an O-allyl oxime fragment as a mimic of a click partner, revealing a mechanism for accelerating syn-triazole formation, which allows generation of its own distinct inhibitor. We have also performed density functional theory calculations based on the X-ray structure to explore the acceleration of the Huisgen cycloaddition by SmChiB. The density functional theory calculations reasonably support that SmChiB plays a role by the cage effect during the pretranslation and posttranslation states of selective syn-triazole click formation. PMID:24043811

  10. Comparison between model predictions and observations of ELF radio atmospherics generated by rocket-triggered lightning

    NASA Astrophysics Data System (ADS)

    Dupree, N. A.; Moore, R. C.

    2011-12-01

    Model predictions of the ELF radio atmospheric generated by rocket-triggered lightning are compared with observations performed at Arrival Heights, Antarctica. The ability to infer source characteristics using observations at great distances may prove to greatly enhance the understanding of lightning processes that are associated with the production of transient luminous events (TLEs) as well as other ionospheric effects associated with lightning. The modeling of the sferic waveform is carried out using a modified version of the Long Wavelength Propagation Capability (LWPC) code developed by the Naval Ocean Systems Center over a period of many years. LWPC is an inherently narrowband propagation code that has been modified to predict the broadband response of the Earth-ionosphere waveguide to an impulsive lightning flash while preserving the ability of LWPC to account for an inhomogeneous waveguide. ELF observations performed at Arrival Heights, Antarctica during rocket-triggered lightning experiments at the International Center for Lightning Research and Testing (ICLRT) located at Camp Blanding, Florida are presented. The lightning current waveforms directly measured at the base of the lightning channel (at the ICLRT) are used together with LWPC to predict the sferic waveform observed at Arrival Heights under various ionospheric conditions. This paper critically compares observations with model predictions.

  11. The German Earth observation programme: building on the success of TerraSAR-X and RapidEye

    NASA Astrophysics Data System (ADS)

    Schaadt, Peter

    2007-10-01

    In addition to five years of routine operations of SCIAMACHY on-board of ESA's ENVISAT mission, the launches of the TerraSAR-X and RapidEye missions and the beginning of both their operational phases are the major milestones for the German Space Programme in 2007 and 2008. These two missions will contribute significantly to the European GMES-Initiative and to the Global Earth Observation System of Systems (GEOSS) and enhance the knowledge about state and dynamics of the Earth's system. Both missions are implemented under public-private-partnership between government and industry, an innovative economic scheme for space mission implementation. With the TanDEM-X and the Hyperspectral EnMAP mission this efficient way of sharing competences, costs and responsibilities on one hand and benefits on the other hand will be further followed. In addition, with MetImage Germany started the development of an imaging radiometer for the European post-EPS satellite system of EUMETSAT. These five attractive missions are important contributions of the German Earth Observation Community to the global system. This investment underlines the political objective of Europe and Germany to advance the environmental agenda. In parallel technology developments for next generation Earth Observation instruments have started, namely High Resolution Wide Swath SAR (Synthetic Aperture Radar), IR detectors and coolers, optical components and mechanisms for LEO and GEO and high power Mixed Garnet laser transmitters for LIDAR (Light Detecting and Ranging) applications. With these activities Germany will be able to provide future Earth Observation missions with suitable technologies as an answer to the increasing complexity of user requirements. In this paper the objectives and the strategy of the German Earth Observation Programme will be explained and the main elements, i.e. missions and technology developments as well as the plans for the future will be introduced.

  12. On the generation of the sequence of diffuse resonances observed on top side ionograms

    NASA Technical Reports Server (NTRS)

    Benson, R. F.

    1974-01-01

    Two different plasma wave instabilities have been invoked in earlier models for the generation of top side ionogram diffuse resonances. Arguments are presented that support the model based on the Harris instability, i.e., the instability resulting from a sounder-stimulated anisotropic electron velocity distribution. Two modifications to this model are also presented. First, it is only necessary for the instability mechanism to operate for a period of the order of milliseconds (rather than tens of milliseconds) in order to explain the observations. Second, the wave associated with the second harmonic of the electron cyclotron frequency, which enters into the nonlinear wave-wave interaction process included in the model, comes from the side bands of the transmitted sounder pulse rather than from the turbulent state of the plasma caused by the pulse. The second modification provides an explanation for the variation of the time duration observed among the members of the sequence of diffuse resonances.

  13. Speckle correlation measurement in a disordered medium observed through second-harmonics generation

    NASA Astrophysics Data System (ADS)

    Ito, Tetsu; Tomita, Makoto

    2004-03-01

    We examined speckle correlation in a disordered medium consisting of LiNbO3 corpuscles, by observing the total intensity of the second-harmonics (SH) light generated by angular correlated two excitation beams. The total SH intensity showed a correlation peak at θ˜0, where θ was the angle between two excitation beams, and decreased as θ was increased. The observation could be understood as the effect of the constructive interference between two volume speckle patterns produced by the excitation beams inside the medium, and the peak could reflect the mutual correlation between two patterns. The experimental results showed good agreements with a theoretical analysis based on a diffusion approximation.

  14. Runoff-generated debris flows: observations and modeling of surge initiation, magnitude, and frequency

    USGS Publications Warehouse

    Kean, Jason W.; McCoy, Scott W.; Tucker, Gregory E.; Staley, Dennis M.; Coe, Jeffrey A.

    2013-01-01

    Runoff during intense rainstorms plays a major role in generating debris flows in many alpine areas and burned steeplands. Yet compared to debris flow initiation from shallow landslides, the mechanics by which runoff generates a debris flow are less understood. To better understand debris flow initiation by surface water runoff, we monitored flow stage and rainfall associated with debris flows in the headwaters of two small catchments: a bedrock-dominated alpine basin in central Colorado (0.06 km2) and a recently burned area in southern California (0.01 km2). We also obtained video footage of debris flow initiation and flow dynamics from three cameras at the Colorado site. Stage observations at both sites display distinct patterns in debris flow surge characteristics relative to rainfall intensity (I). We observe small, quasiperiodic surges at low I; large, quasiperiodic surges at intermediate I; and a single large surge followed by small-amplitude fluctuations about a more steady high flow at high I. Video observations of surge formation lead us to the hypothesis that these flow patterns are controlled by upstream variations in channel slope, in which low-gradient sections act as “sediment capacitors,” temporarily storing incoming bed load transported by water flow and periodically releasing the accumulated sediment as a debris flow surge. To explore this hypothesis, we develop a simple one-dimensional morphodynamic model of a sediment capacitor that consists of a system of coupled equations for water flow, bed load transport, slope stability, and mass flow. This model reproduces the essential patterns in surge magnitude and frequency with rainfall intensity observed at the two field sites and provides a new framework for predicting the runoff threshold for debris flow initiation in a burned or alpine setting.

  15. Aerosol products generated by GRASP algorithm from PARASOL and MERIS/Envisat satellite observations

    NASA Astrophysics Data System (ADS)

    Dubovik, Oleg; Litvinov, Pavel; Lapyonok, Tatyana; Ducos, Fabrice; Huang, Xin; Lopatin, Anton; Fuertes, David; Torres, Benjamin; Ogris, Georg; Federspiel, Christian; Aspetsberger, Michael; Fischer, Jürgen; Bojkov, Bojan

    2017-04-01

    The presentation discusses aerosol satellite products produced by the recently developed algorithm of new generation GRASP (Dubovik et al. 2011, 2014). GRASP is complex algorithm realized as open source software (http://www.grasp-open.com/). It is applicable both to satellite and ground-based observations. The particularity of GRASP is that it allows for implementing advanced retrieval scenarios. In most of application GRASP doesn't utilize look-up-tables and searches in continuous space. In all applications GRASP realizes rigorous statistically optimized fitting based on multi-term LSM approach (Dubovik 2004) that includes several original features. For example, GRASP satellite retrieval is based on multi-pixel concept when the optimized retrieval is implemented simultaneously for a large group of measurements, such as a group of satellite pixels or a group of coordinated ground-based observations. This approach helps to use additional a priori information about limited variability of aerosol of surface properties in time and/or space that stabilize the retrieval. In addition, GRASP generates several radiatively consistent products by retrieving both aerosol and underlying surface properties simultaneously from satellite observations using the same retrieval assumptions globally. As a result, GRASP provides reliable retrieval of some detailed aerosol properties that are traditionally difficult to obtain from remote sensing. For example, from the observations of PARASOL polarimeter GRASP retrieves not only spectrally dependent aerosol optical thickness and also spectra aerosol absorption over both ocean dark and land reflective surfaces and even some information about aerosol vertical distribution. Also, the basic aerosol retrieved parameters as aerosol optical thickness and its spectral dependence are expected to be retrieved with the enhanced accuracy. The climatological results of retrievals from two rather different satellite missions: PARASOL and MERIS

  16. Observation requirements for the second generation EUMETSAT polar system visible/infrared imager

    NASA Astrophysics Data System (ADS)

    Phillips, P. L.; Schlüssel, P.; Accadia, C. J.; Banfi, S.; Zerfowski, I.

    2011-11-01

    The EUMETSAT Polar System Second Generation (EPS-SG) will continue operational meteorological measurements from polar orbiting satellites in the mid-morning orbit in the 2020 timeframe. The Metop Second Generation (Metop- SG) satellites will carry a payload which is primarily dedicated to operational meteorology and climate monitoring. A core mission within this payload is an optical imager required to meet the imagery user needs for Numerical Weather Prediction (NWP), Nowcasting (NWC) and climate applications. As NWP progresses towards operation on higher spatial resolution grids, improved representation of atmospheric processes encompassing the whole Earth system will be required, hence the availability of observations of clouds and aerosols as well as surface parameters will play an increasing role in a skilful weather forecast. Imagery data will also be very important in NWC applications, particularly in polar regions where space-borne imagery from geostationary satellites is not available. The EPS-SG Visible/Infrared Imaging mission (VII) follows on from an important list of predecessors such as the Advanced Very High Resolution Radiometer (AVHRR) and the Moderate resolution Imaging Spectro-radiometer (MODIS). The VII mission is planned to be implemented by the METimage instrument, developed by Deutsches Zentrum für Luft und Raumfahrt (DLR). METimage is a cross-purpose medium resolution, multi-spectral optical imager, measuring the optical spectrum of radiation emitted and reflected by the Earth from a low-altitude sun synchronous orbit over a minimum swath width of 2800 km. The spectral and radiometric performances and space-time resolution introduce novel observing capabilities that will enhance the observation potential compared to current operational optical imagers. These enhanced capabilities along with the evolution of the VII observation requirements are discussed.

  17. Runoff-generated debris flows: Observations and modeling of surge initiation, magnitude, and frequency

    NASA Astrophysics Data System (ADS)

    Kean, Jason W.; McCoy, Scott W.; Tucker, Gregory E.; Staley, Dennis M.; Coe, Jeffrey A.

    2013-12-01

    during intense rainstorms plays a major role in generating debris flows in many alpine areas and burned steeplands. Yet compared to debris flow initiation from shallow landslides, the mechanics by which runoff generates a debris flow are less understood. To better understand debris flow initiation by surface water runoff, we monitored flow stage and rainfall associated with debris flows in the headwaters of two small catchments: a bedrock-dominated alpine basin in central Colorado (0.06 km2) and a recently burned area in southern California (0.01 km2). We also obtained video footage of debris flow initiation and flow dynamics from three cameras at the Colorado site. Stage observations at both sites display distinct patterns in debris flow surge characteristics relative to rainfall intensity (I). We observe small, quasiperiodic surges at low I; large, quasiperiodic surges at intermediate I; and a single large surge followed by small-amplitude fluctuations about a more steady high flow at high I. Video observations of surge formation lead us to the hypothesis that these flow patterns are controlled by upstream variations in channel slope, in which low-gradient sections act as "sediment capacitors," temporarily storing incoming bed load transported by water flow and periodically releasing the accumulated sediment as a debris flow surge. To explore this hypothesis, we develop a simple one-dimensional morphodynamic model of a sediment capacitor that consists of a system of coupled equations for water flow, bed load transport, slope stability, and mass flow. This model reproduces the essential patterns in surge magnitude and frequency with rainfall intensity observed at the two field sites and provides a new framework for predicting the runoff threshold for debris flow initiation in a burned or alpine setting.

  18. Simultaneous observations of storm-generated sprite and gravity wave over Bangladesh

    NASA Astrophysics Data System (ADS)

    Chou, Chien-Chung; Dai, Jeff; Kuo, Cheng-Ling; Huang, Tai-Yin

    2016-09-01

    We report simultaneous observations of sprite and gravity wave generated by a storm over Bangladesh. The origin of a concentric gravity wave can be traced to the storm region on 27 April 2014 over Bangladesh with a low cloud top surface temperature (175 K). After data analysis, the time period of the concentric gravity wave is found to be 8.8-8.9 min. The horizontal wavelength is found to be 50 km for red emissions ( 55 km for green emissions), and the horizontal phase velocity is 94.4 ± 31.7 m s-1 for red emissions (102.6 ± 29.4 m s-1 for green emissions). Using the dispersion relation of gravity wave, the elevation angle of wave propagation direction is found to be 53.3°. The sprite associated with the gravity wave was also recorded at 1534 UT on 27 April 2014. The initiation time of storm-generated gravity wave is estimated to be 1454 UT at which lightning activity was relatively low using lightning data. At time 1534 UT of the recorded sprite, the lightning rate was close to its maximum value. The storm-generated gravity wave could be thought as a precursor phenomenon for lightning and sprites since one of the necessary conditions for gravity wave, lightning, and sprites is strong convection inside storms.

  19. Designing a high-availability cluster for the Subaru Telescope second generation observation control system

    NASA Astrophysics Data System (ADS)

    Jeschke, Eric; Inagaki, Takeshi

    2010-07-01

    Subaru Telescope is commissioning a second-generation Observation Control System (OCS), building upon a 10 hear history of using the first generation OCS. One of the primary lessons learned about maintaining a distributed OCS system is that the idea of individual computer nodes specialized for specific functions greatly complicates troubleshooting and failover, even with a dedicated "hot spare" for each specialized node. In contrast, the Generation 2 (Gen2) system was designed from the ground up around the principle of a High-Availability (HA) cluster, commonly used for high-traffic, mission-critical web sites. In such a cluster, nodes are not specialized, and any node can perform any function of the OCS. We describe the problems encountered in trying to troubleshoot and manage failure on the legacy OCS system and describe the architectural design of the HA cluster for the new system, including special characteristics designed for the high-altitude, remote environment of the summit of Mauna Kea, where there is a greatly increased probability of such failures. Although the focus is primarily on the hardware, we touch upon the software architecture written to take advantage of the features of the HA cluster design. Finally, we outline the advantages of the new system and show how the design greatly facilitates troubleshooting, robustness and ease of failure management. The results may be of interest to anyone designing a distributed system using COTS hardware and open-source software to withstand failure and improve manageability in a remote environment.

  20. Simultaneous observations of storm-generated sprite and gravity wave over Bangladesh

    NASA Astrophysics Data System (ADS)

    Kuo, C. L.; Chou, C. C.; Huang, T. Y.

    2016-12-01

    We report simultaneous observations of sprite and gravity wave generated by a storm over Bangladesh. The origin of a concentric gravity wave can be traced to the storm region on Apr 27, 2014 over Bangladesh with a low cloud top surface temperature (175K). After data analysis, the time period of the concentric gravity wave is found to be 8.8-8.9 minutes. The horizontal wavelength is found to be 50 km for red emissions ( 55 km for green emissions) and the horizontal phase velocity is 94.4 ± 31.7 m s-1 for red emissions (102.6 ± 29.4 m s-1 for green emissions). Using the dispersion relation of gravity wave, the elevation angle of wave propagation direction is found to be 53.3 º. The sprite associated with the gravity wave was also recorded at 1534 UT on Apr 27, 2014. The initiation time of storm-generated gravity wave is estimated to be 1454 UT at which lightning activity was relatively low using lightning data. At time 1534 UT of the recorded sprite, the lightning rate was close to its maximum value. The storm-generated gravity wave could be thought as a precursor phenomenon for lightning and sprites since one of the necessary conditions for gravity wave, lightning and sprites is strong convection inside storms.

  1. Observation of magnetic field generation via the Weibel instability in interpenetrating plasma flows

    NASA Astrophysics Data System (ADS)

    Huntington, C. M.; Fiuza, F.; Ross, J. S.; Zylstra, A. B.; Drake, R. P.; Froula, D. H.; Gregori, G.; Kugland, N. L.; Kuranz, C. C.; Levy, M. C.; Li, C. K.; Meinecke, J.; Morita, T.; Petrasso, R.; Plechaty, C.; Remington, B. A.; Ryutov, D. D.; Sakawa, Y.; Spitkovsky, A.; Takabe, H.; Park, H.-S.

    2015-02-01

    Collisionless shocks can be produced as a result of strong magnetic fields in a plasma flow, and therefore are common in many astrophysical systems. The Weibel instability is one candidate mechanism for the generation of sufficiently strong fields to create a collisionless shock. Despite their crucial role in astrophysical systems, observation of the magnetic fields produced by Weibel instabilities in experiments has been challenging. Using a proton probe to directly image electromagnetic fields, we present evidence of Weibel-generated magnetic fields that grow in opposing, initially unmagnetized plasma flows from laser-driven laboratory experiments. Three-dimensional particle-in-cell simulations reveal that the instability efficiently extracts energy from the plasma flows, and that the self-generated magnetic energy reaches a few percent of the total energy in the system. This result demonstrates an experimental platform suitable for the investigation of a wide range of astrophysical phenomena, including collisionless shock formation in supernova remnants, large-scale magnetic field amplification, and the radiation signature from gamma-ray bursts.

  2. Observation of magnetic field generation via the Weibel instability in interpenetrating plasma flows

    SciTech Connect

    Huntington, C. M.; Fiuza, F.; Ross, J. S.; Zylstra, A. B.; Drake, R. P.; Froula, D. H.; Gregori, G.; Kugland, N. L.; Kuranz, C. C.; Levy, M. C.; Li, C. K.; Meinecke, J.; Morita, T.; Petrasso, R.; Plechaty, C.; Remington, B. A.; Ryutov, D. D.; Sakawa, Y.; Spitkovsky, A.; Takabe, H.; Park, H.-S.

    2015-01-19

    Collisionless shocks can be produced as a result of strong magnetic fields in a plasma flow, and therefore are common in many astrophysical systems. The Weibel instability is one candidate mechanism for the generation of su fficiently strong fields to create a collisionless shock. Despite their crucial role in astrophysical systems, observation of the magnetic fields produced by Weibel instabilities in experiments has been challenging. Using a proton probe to directly image electromagnetic fields, we present evidence of Weibel-generated magnetic fields that grow in opposing, initially unmagnetized plasma flows from laser-driven laboratory experiments. Three-dimensional particle-in-cell simulations reveal that the instability effi ciently extracts energy from the plasma flows, and that the self-generated magnetic energy reaches a few percent of the total energy in the system. Furthermore, this result demonstrates an experimental platform suitable for the investigation of a wide range of astrophysical phenomena, including collisionless shock formation in supernova remnants, large-scale magnetic field amplification, and the radiation signature from gamma-ray bursts.

  3. First-Generation, Low-Income College Students during the First Semester in Higher Education: Challenges and Successes

    ERIC Educational Resources Information Center

    Chhen Stewart, Lee May

    2012-01-01

    Typically, studies first-generation, low-income students have focused on the financial aid and academic preparedness to enter college and persist. These researchers have found little data about first-generation, low-income students once they enter higher education. One question largely unexplored has been why some first-generation, low-income…

  4. Performance Evaluation of New-Generation Pulse Oximeters in the NICU: Observational Study.

    PubMed

    Nizami, Shermeen; Greenwood, Kim; Barrowman, Nick; Harrold, JoAnn

    2015-09-01

    This crossover observational study compares the data characteristics and performance of new-generation Nellcor OXIMAX and Masimo SET SmartPod pulse oximeter technologies. The study was conducted independent of either original equipment manufacturer (OEM) across eleven preterm infants in a Neonatal Intensive Care Unit (NICU). The SmartPods were integrated with Dräger Infinity Delta monitors. The Delta monitor measured the heart rate (HR) using an independent electrocardiogram sensor, and the two SmartPods collected arterial oxygen saturation (SpO2) and pulse rate (PR). All patient data were non-Gaussian. Nellcor PR showed a higher correlation with the HR as compared to Masimo PR. The statistically significant difference found in their median values (1% for SpO2, 1 bpm for PR) was deemed clinically insignificant. SpO2 alarms generated by both SmartPods were observed and categorized for performance evaluation. Results for sensitivity, positive predictive value, accuracy and false alarm rates were Nellcor (80.3, 50, 44.5, 50%) and Masimo (72.2, 48.2, 40.6, 51.8%) respectively. These metrics were not statistically significantly different between the two pulse oximeters. Despite claims by OEMs, both pulse oximeters exhibited high false alarm rates, with no statistically or clinically significant difference in performance. These findings have a direct impact on alarm fatigue in the NICU. Performance evaluation studies can also impact medical device purchase decisions made by hospital administrators.

  5. Generation of mesoscale eddies and squirts in the southeast Baltic Sea: modelling and observations

    NASA Astrophysics Data System (ADS)

    Zhurbas, V.; Stipa, T.; Mälkki, P.; Paka, V.; Golenko, N.; Hense, I.

    2003-04-01

    Closely spaced CTD measurements performed in the southeast Baltic Sea during summertime reveal localized simultaneous deepenings of the seasonal thermocline and swellings of the permanent halocline which result in localized convergences of isopycnals towards the intermediate layer. In view of geostrophic balance, such mesoscale baroclinic disturbances can be interpreted as the cyclonic eddies within the intermediate layer. They were observed in the Bornholm Deep, the Stolpe Channel ,the Gulf of Gdansk, and the southern part of East Gotland Basin. In the case of the Stolpe Channel, the cyclones were satisfactory reproduced in numerical experiments with a sigma-coordinate, Princeton Ocean Model (POM) in which horizontal grid sell size was as small as 0.5 km. The diameter of modelled cyclones (approx. 15 km) fits well that of the observations. The cyclones are shown to be generated during the adjustment of the high potential vorticity (PV) outflow (in this particular case from the Bornholm basin via the Stolpe Sill) to low vorticity environment by vortex stretching (so-called the PV outflow hypothesis by Spall and Price (1998)). In addition to the cyclones in the Stolpe Channel, numerical experiments with easterly wind yield exiting possibility to watch squirts and mesoscale eddies, both cyclones and anticyclones, generated in the upper layer due to the instability of the upwelling front off the southern coast of the sea.

  6. Extracting More Information from Passive Optical Tracking Observations for Reliable Orbit Element Generation

    NASA Astrophysics Data System (ADS)

    Bennett, J.; Gehly, S.

    2016-09-01

    This paper presents results from a preliminary method for extracting more orbital information from low rate passive optical tracking data. An improvement in the accuracy of the observation data yields more accurate and reliable orbital elements. A comparison between the orbit propagations from the orbital element generated using the new data processing method is compared with the one generated from the raw observation data for several objects. Optical tracking data collected by EOS Space Systems, located on Mount Stromlo, Australia, is fitted to provide a new orbital element. The element accuracy is determined from a comparison between the predicted orbit and subsequent tracking data or reference orbit if available. The new method is shown to result in a better orbit prediction which has important implications in conjunction assessments and the Space Environment Research Centre space object catalogue. The focus is on obtaining reliable orbital solutions from sparse data. This work forms part of the collaborative effort of the Space Environment Management Cooperative Research Centre which is developing new technologies and strategies to preserve the space environment (www.serc.org.au).

  7. On the Generation of Multiple Atmospheric Pressure Waves Observed During Violent Volcanic Eruptions.

    NASA Astrophysics Data System (ADS)

    Medici, E. F.; Waite, G. P.

    2015-12-01

    One or more atmospheric pressure waves followed by a supersonic jet may be generated during the over pressurized vapor-solid-liquid mixture ejection of a violent volcanic eruption. The source of these multiple atmospheric pressure waves could have different origins. Among the physical mechanisms that could explain these behaviors are pulsating eruptions, the dynamics of shock waves, coupled pressure wave-supersonic jet interaction, or a combination of all these factors. In order to elucidate the causes of these complex fluid flow dynamics, a series of analog volcanic eruption experiments using an atmospheric shock tube were performed. During the testing, single and multiple pressure waves and the subsequent supersonic jet were generated. The controlled laboratory conditions enable studies of the most relevant variables potentially responsible for the formation of the multiple pressure waves. The tests were performed using dry, compressed nitrogen at standard room temperature that was free of particles. Yet, under this idealization of a real volcanic eruption, multiple pressure waves were observed on the high-speed video imaging and recorded on the pressure transducer. The amount of energy being released on each test was varied to achieve different discharge dynamics and the formation of single and multiple pressure waves. The preliminary experimental observations indicate a coupled pressure wave-jet interaction as source of multiple pressure waves.

  8. Clinical success of stainless steel crowns placed under general anaesthesia in primary molars: an observational follow up study.

    PubMed

    Schüler, I M; Hiller, M; Roloff, T; Kühnisch, J; Heinrich-Weltzien, R

    2014-11-01

    Quality assessment of stainless steel crowns (SSCs) placed in primary molars of high caries risk children after 1, 3 and 5 years of service time. Out of 1149 SSCs placed 1, 3 or 5 years before the evaluation period in 558 children, 428 (37.2%) SSCs were clinically evaluated in 171 (30.6%) children aged between 1.1 and 8.6 years. Marginal adaptation, extension and proximal contacts of SSCs, plaque and gingival bleeding at SSC were assessed. Caries experience was recorded by WHO standards. Caries experience was 7.8 dmft/18.4 dmfs before treatment. The overall success rate of SSCs was 97.2%, regardless of the extent of carious lesions or pulp treatment of the tooth. Loss of SSCs (1.9%), pathological tooth mobility (0.7%) and perforation of the crown (0.2%) were scored as clinical failures. The majority of SSCs had sealed margins and the marginal extension reached sub-gingival level. Open proximal contacts occurred mesially and distally (21.7%, 20%). All qualitative defects increased with service time. Secondary caries was not diagnosed. Of the SSCs, 46.4% were free of dental plaque. Gingival bleeding after probing was observed in 72.1% of all SSCs. Gingivitis was significantly associated with increased dmft-values (OR=1.108, 95%CI: 1.03-1.19) and plaque at SSCs (OR=0.29, 95%CI: 0.18-0.47). Children with migration background exhibited significantly more often insufficient oral hygiene and higher rates of gingival bleeding and caries experience than did German children. SSCs are clinically successful restorations in primary molars of high caries risk children. High caries prevalence and insufficient oral hygiene were greater determining factors for the occurrence of gingivitis than the quality of the SSCs. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. Successful Outcomes with Oral Fluoroquinolones Combined with Rifampicin in the Treatment of Mycobacterium ulcerans: An Observational Cohort Study

    PubMed Central

    O'Brien, Daniel P.; McDonald, Anthony; Callan, Peter; Robson, Mike; Friedman, N. Deborah; Hughes, Andrew; Holten, Ian; Walton, Aaron; Athan, Eugene

    2012-01-01

    Background The World Health Organization currently recommends combined streptomycin and rifampicin antibiotic treatment as first-line therapy for Mycobacterium ulcerans infections. Alternatives are needed when these are not tolerated or accepted by patients, contraindicated, or neither accessible nor affordable. Despite in vitro effectiveness, clinical evidence for fluoroquinolone antibiotic use against Mycobacterium ulcerans is lacking. We describe outcomes and tolerability of fluoroquinolone-containing antibiotic regimens for Mycobacterium ulcerans in south-eastern Australia. Methodology/Principal Findings Analysis was performed of prospectively collected data including all primary Mycobacterium ulcerans infections treated at Barwon Health between 1998 and 2010. Medical treatment involved antibiotic use for more than 7 days; surgical treatment involved surgical excision of a lesion. Treatment success was defined as complete lesion healing without recurrence at 12 months follow-up. A complication was defined as an adverse event attributed to an antibiotic that required its cessation. A total of 133 patients with 137 lesions were studied. Median age was 62 years (range 3–94 years). 47 (34%) had surgical treatment alone, and 90 (66%) had combined surgical and medical treatment. Rifampicin and ciprofloxacin comprised 61% and rifampicin and clarithromycin 23% of first-line antibiotic regimens. 13/47 (30%) treated with surgery alone failed treatment compared to 0/90 (0%) of those treated with combination medical and surgical treatment (p<0.0001). There was no difference in treatment success rate for antibiotic combinations containing a fluoroquinolone (61/61 cases; 100%) compared with those not containing a fluoroquinolone (29/29 cases; 100%). Complication rates were similar between ciprofloxacin and rifampicin (31%) and rifampicin and clarithromycin (33%) regimens (OR 0.89, 95% CI 0.27–2.99). Paradoxical reactions during treatment were observed in 8 (9%) of

  10. Microwave Polarized Signatures Generated within Cloud Systems: SSM/I Observations Interpreted with Radiative Transfer Simulations

    NASA Technical Reports Server (NTRS)

    Prigent, Catherine; Pardo, Juan R.; Mishchenko, Michael I.; Rossow, Willaim B.; Hansen, James E. (Technical Monitor)

    2001-01-01

    Special Sensor Microwave /Imager (SSM/I) observations in cloud systems are studied over the tropics. Over optically thick cloud systems, presence of polarized signatures at 37 and 85 GHz is evidenced and analyzed with the help of cloud top temperature and optical thickness extracted from visible and IR satellite observations. Scattering signatures at 85 GHz (TbV(85) less than or = 250 K) are associated with polarization differences greater than or = 6 K, approx. 50%, of the time over ocean and approx. 40% over land. In addition. over thick clouds the polarization difference at 37 GHz is rarely negligible. The polarization differences at 37 and 85 GHz do not stem from the surface but are generated in regions of relatively homogeneous clouds having high liquid water content. To interpret the observations, a radiative transfer model that includes the scattering by non-spherical particles is developed. based on the T-matrix approach and using the doubling and adding method. In addition to handling randomly and perfectly oriented particles, this model can also simulate the effect of partial orientation of the hydrometeors. Microwave brightness temperatures are simulated at SSM/I frequencies and are compared with the observations. Polarization differences of approx. 2 K can be simulated at 37 GHz over a rain layer, even using spherical drops. The polarization difference is larger for oriented non-spherical particles. The 85 GHz simulations are very sensitive to the ice phase of the cloud. Simulations with spherical particles or with randomly oriented non-spherical ice particles cannot replicate the observed polarization differences. However, with partially oriented non-spherical particles, the observed polarized signatures at 85 GHz are explained, and the sensitivity of the scattering characteristics to the particle size, asphericity, and orientation is analyzed. Implications on rain and ice retrievals are discussed.

  11. A review of tropical cyclone-generated storm surges: Global data sources, observations, and impacts

    NASA Astrophysics Data System (ADS)

    Needham, Hal F.; Keim, Barry D.; Sathiaraj, David

    2015-06-01

    Tropical cyclone-generated storm surges are among the world's most deadly and destructive natural hazards. This paper provides the first comprehensive global review of tropical storm surge data sources, observations, and impacts while archiving data in SURGEDAT, a global database. Available literature has provided data for more than 700 surge events since 1880, the majority of which are found in the western North Atlantic (WNA), followed by Australia/Oceania, the western North Pacific (WNP), and the northern Indian Ocean (NIO). The Bay of Bengal (BOB) in the NIO consistently observes the world's highest surges, as this subbasin averages five surges ≥5 m per decade and has observed credible storm tide levels reaching 13.7 m. The WNP observes the highest rate of low-magnitude surges, as the coast of China averages 54 surges ≥1 m per decade, and rates are likely higher in the Philippines. The U.S. Gulf Coast observes the second highest frequency of both high-magnitude (≥5 m) and low-magnitude (≥1 m) surges. The BOB observes the most catastrophic surge impacts, as 59% of global tropical cyclones that have killed at least 5000 people occurred in this basin. The six deadliest cyclones in this region have each killed at least 140,000 people, and two events have killed 300,000. Storm surge impacts transportation, agriculture, and energy sectors in the WNA. Oceania experiences long-term impacts, including contamination of fresh water and loss of food supplies, although the highest surges in this region are lower than most other basins.

  12. Comparison of Retention Factors between First-Generation and Second- and Third-Generation College Students and Development of the Likelihood of Success Model

    ERIC Educational Resources Information Center

    Williams, Gerri Brown

    2009-01-01

    The purpose of this study was to compare the retention factors between first-generation college students and second- and third-generation college students in the postsecondary educational setting. This study examined the differences in the preselected retention factors: faculty-student interaction, college mentor, academic support, residential…

  13. The Relationship of Perceived Intellectual and Social Attainment to Academic Success of First-Generation, First-Year College Students Participating in a First Generation Access Program

    ERIC Educational Resources Information Center

    Bergeron, Dyonne Michelle

    2013-01-01

    The purpose of this study was to advance understanding of perceived intellectual and social attainment gains of first-generation, first-year college students participating in First Generation Access Programs at the University of South Florida (USF), a large, public research university in Florida. Understanding the self-reported intellectual and…

  14. HEXITEC: A Next Generation Hard X-ray Detector for Solar Observations

    NASA Astrophysics Data System (ADS)

    Ryan, Daniel; Christe, Steven; Shih, Albert; Inglis, Andrew R.; Gregory, Kyle; Baumgartner, Wayne H.; Gaskin, Jessica; Wilson-Hodge, Colleen; Seller, Paul; Wilson, Matthew; Veale, Matthew C.; Panessa, Marco

    2016-05-01

    There is an increasing demand in solar physics for high resolution X-ray spectroscopic imaging. Such observations would present ground-breaking opportunities to study the poorly understood high energy processes in the solar corona such as solar flares, coronal heating, etc. However, such observations require a new breed of solid-state detectors sensititve to high energy X-rays with fine independent pixels to subsample the point spread function (PSF) of the X-ray optics. They must also be capable of handling very high count rates as photon fluxes from solar flares often cause pileup in current detectors. The Rutherford Appleton Laboratory (RAL) has recently developed a new Cadmium Telluride (CdTe) detector system, dubbed HEXITEC (High Energy X-ray Imaging Technology). It is an 80x80 array of 250 micron independent pixels sensitive in the 4--80 keV band and capable of a high full frame readout rate of 10 kHz. HEXITEC provides the smallest independently read out pixels currently available, and are well matched to the few arcsecond PSF produced by the current and next generation hard X-ray focusing optics. NASA's Goddard and Marshall Space Flight Centers are collaborating with RAL to develop these detectors for use on future space-borne hard X-ray focusing telescopes. In this poster we show the latest results on HEXITEC's imaging capability, high read out rate, and energy sensitivity and reveal it to be ideal for such future instruments. The potential observations obtained by combining HEXITEC with the next generation of X-ray focusing optics could to revolutionize our understanding of high energy processes in the solar corona.

  15. Assessing the GOANNA Visual Field Algorithm Using Artificial Scotoma Generation on Human Observers

    PubMed Central

    Chong, Luke X.; Turpin, Andrew; McKendrick, Allison M.

    2016-01-01

    Purpose To validate the performance of a new perimetric algorithm (Gradient-Oriented Automated Natural Neighbor Approach; GOANNA) in humans using a novel combination of computer simulation and human testing, which we call Artificial Scotoma Generation (ASG). Methods Fifteen healthy observers were recruited. Baseline conventional automated perimetry was performed on the Octopus 900. Visual field sensitivity was measured using two different procedures: GOANNA and Zippy Estimation by Sequential Testing (ZEST). Four different scotoma types were induced in each observer by implementing a novel technique that inserts a step between the algorithm and the perimeter, which in turn alters presentation levels to simulate scotomata in human observers. Accuracy, precision, and unique number of locations tested were measured, with the maximum difference between a location and its neighbors (Max_d) used to stratify results. Results GOANNA sampled significantly more locations than ZEST (paired t-test, P < 0.001), while maintaining comparable test times. Difference plots showed that GOANNA displayed greater accuracy than ZEST when Max_d was in the 10 to 30 dB range (with the exception of Max_d = 20 dB; Wilcoxon, P < 0.001). Similarly, GOANNA demonstrated greater precision than ZEST when Max_d was in the 20 to 30 dB range (Wilcoxon, P < 0.001). Conclusions We have introduced a novel method for assessing accuracy of perimetric algorithms in human observers. Results observed in the current study agreed with the results seen in earlier simulation studies, and thus provide support for performing larger scale clinical trials with GOANNA in the future. Translational Relevance The GOANNA perimetric testing algorithm offers a new paradigm for visual field testing where locations for testing are chosen that target scotoma borders. Further, the ASG methodology used in this paper to assess GOANNA shows promise as a hybrid between computer simulation and patient testing, which may allow more

  16. The Ginger-shaped Asteroid 4179 Toutatis: New Observations from a Successful Flyby of Chang'e-2

    NASA Astrophysics Data System (ADS)

    Huang, Jiangchuan; Ji, Jianghui; Ye, Peijian; Wang, Xiaolei; Yan, Jun; Meng, Linzhi; Wang, Su; Li, Chunlai; Li, Yuan; Qiao, Dong; Zhao, Wei; Zhao, Yuhui; Zhang, Tingxin; Liu, Peng; Jiang, Yun; Rao, Wei; Li, Sheng; Huang, Changning; Ip, Wing-Huen; Hu, Shoucun; Zhu, Menghua; Yu, Liangliang; Zou, Yongliao; Tang, Xianglong; Li, Jianyang; Zhao, Haibin; Huang, Hao; Jiang, Xiaojun; Bai, Jinming

    2013-12-01

    On 13 December 2012, Chang'e-2 conducted a successful flyby of the near-Earth asteroid 4179 Toutatis at a closest distance of 770 +/- 120 meters from the asteroid's surface. The highest-resolution image, with a resolution of better than 3 meters, reveals new discoveries on the asteroid, e.g., a giant basin at the big end, a sharply perpendicular silhouette near the neck region, and direct evidence of boulders and regolith, which suggests that Toutatis may bear a rubble-pile structure. Toutatis' maximum physical length and width are (4.75 × 1.95 km) +/-10%, respectively, and the direction of the +z axis is estimated to be (250 +/- 5°, 63 +/- 5°) with respect to the J2000 ecliptic coordinate system. The bifurcated configuration is indicative of a contact binary origin for Toutatis, which is composed of two lobes (head and body). Chang'e-2 observations have significantly improved our understanding of the characteristics, formation, and evolution of asteroids in general.

  17. The ginger-shaped asteroid 4179 Toutatis: new observations from a successful flyby of Chang'e-2.

    PubMed

    Huang, Jiangchuan; Ji, Jianghui; Ye, Peijian; Wang, Xiaolei; Yan, Jun; Meng, Linzhi; Wang, Su; Li, Chunlai; Li, Yuan; Qiao, Dong; Zhao, Wei; Zhao, Yuhui; Zhang, Tingxin; Liu, Peng; Jiang, Yun; Rao, Wei; Li, Sheng; Huang, Changning; Ip, Wing-Huen; Hu, Shoucun; Zhu, Menghua; Yu, Liangliang; Zou, Yongliao; Tang, Xianglong; Li, Jianyang; Zhao, Haibin; Huang, Hao; Jiang, Xiaojun; Bai, Jinming

    2013-12-12

    On 13 December 2012, Chang'e-2 conducted a successful flyby of the near-Earth asteroid 4179 Toutatis at a closest distance of 770 ± 120 meters from the asteroid's surface. The highest-resolution image, with a resolution of better than 3 meters, reveals new discoveries on the asteroid, e.g., a giant basin at the big end, a sharply perpendicular silhouette near the neck region, and direct evidence of boulders and regolith, which suggests that Toutatis may bear a rubble-pile structure. Toutatis' maximum physical length and width are (4.75 × 1.95 km) ±10%, respectively, and the direction of the +z axis is estimated to be (250 ± 5°, 63 ± 5°) with respect to the J2000 ecliptic coordinate system. The bifurcated configuration is indicative of a contact binary origin for Toutatis, which is composed of two lobes (head and body). Chang'e-2 observations have significantly improved our understanding of the characteristics, formation, and evolution of asteroids in general.

  18. The Ginger-shaped Asteroid 4179 Toutatis: New Observations from a Successful Flyby of Chang'e-2

    PubMed Central

    Huang, Jiangchuan; Ji, Jianghui; Ye, Peijian; Wang, Xiaolei; Yan, Jun; Meng, Linzhi; Wang, Su; Li, Chunlai; Li, Yuan; Qiao, Dong; Zhao, Wei; Zhao, Yuhui; Zhang, Tingxin; Liu, Peng; Jiang, Yun; Rao, Wei; Li, Sheng; Huang, Changning; Ip, Wing-Huen; Hu, Shoucun; Zhu, Menghua; Yu, Liangliang; Zou, Yongliao; Tang, Xianglong; Li, Jianyang; Zhao, Haibin; Huang, Hao; Jiang, Xiaojun; Bai, Jinming

    2013-01-01

    On 13 December 2012, Chang'e-2 conducted a successful flyby of the near-Earth asteroid 4179 Toutatis at a closest distance of 770 ± 120 meters from the asteroid's surface. The highest-resolution image, with a resolution of better than 3 meters, reveals new discoveries on the asteroid, e.g., a giant basin at the big end, a sharply perpendicular silhouette near the neck region, and direct evidence of boulders and regolith, which suggests that Toutatis may bear a rubble-pile structure. Toutatis' maximum physical length and width are (4.75 × 1.95 km) ±10%, respectively, and the direction of the +z axis is estimated to be (250 ± 5°, 63 ± 5°) with respect to the J2000 ecliptic coordinate system. The bifurcated configuration is indicative of a contact binary origin for Toutatis, which is composed of two lobes (head and body). Chang'e-2 observations have significantly improved our understanding of the characteristics, formation, and evolution of asteroids in general. PMID:24336501

  19. Observer success rates for identification of 3D surface reconstructed facial images and implications for patient privacy and security

    NASA Astrophysics Data System (ADS)

    Chen, Joseph J.; Siddiqui, Khan M.; Fort, Leslie; Moffitt, Ryan; Juluru, Krishna; Kim, Woojin; Safdar, Nabile; Siegel, Eliot L.

    2007-03-01

    3D and multi-planar reconstruction of CT images have become indispensable in the routine practice of diagnostic imaging. These tools cannot only enhance our ability to diagnose diseases, but can also assist in therapeutic planning as well. The technology utilized to create these can also render surface reconstructions, which may have the undesired potential of providing sufficient detail to allow recognition of facial features and consequently patient identity, leading to violation of patient privacy rights as described in the HIPAA (Health Insurance Portability and Accountability Act) legislation. The purpose of this study is to evaluate whether 3D reconstructed images of a patient's facial features can indeed be used to reliably or confidently identify that specific patient. Surface reconstructed images of the study participants were created used as candidates for matching with digital photographs of participants. Data analysis was performed to determine the ability of observers to successfully match 3D surface reconstructed images of the face with facial photographs. The amount of time required to perform the match was recorded as well. We also plan to investigate the ability of digital masks or physical drapes to conceal patient identity. The recently expressed concerns over the inability to truly "anonymize" CT (and MRI) studies of the head/face/brain are yet to be tested in a prospective study. We believe that it is important to establish whether these reconstructed images are a "threat" to patient privacy/security and if so, whether minimal interventions from a clinical perspective can substantially reduce this possibility.

  20. Effects of depleted uranium on the reproductive success and F1 generation survival of zebrafish (Danio rerio).

    PubMed

    Bourrachot, Stéphanie; Brion, François; Pereira, Sandrine; Floriani, Magali; Camilleri, Virginie; Cavalié, Isabelle; Palluel, Olivier; Adam-Guillermin, Christelle

    2014-09-01

    Despite the well-characterized occurrence of uranium (U) in the aquatic environment, very little is known about the chronic exposure of fish to low levels of U and its potential effect on reproduction. Therefore, this study was undertaken to investigate the effects of environmental concentrations of depleted U on the reproductive output of zebrafish (Danio rerio) and on survival and development of the F1 embryo-larvae following parental exposure to U. For that purpose, sexually mature male and female zebrafish were exposed to 20 and 250 μg/L of U for 14 days and allowed to reproduce in clean water during a further 14-day period. At all sampling times, whole-body vitellogenin concentrations and gonad histology were analyzed to investigate the effects of U exposure on these reproductive endpoints. In addition, accumulation of U in the gonads and its genotoxic effect on male and female gonad cells were quantified. The results showed that U strongly affected the capability of fish to reproduce and to generate viable individuals as evidenced by the inhibition of egg production and the increased rate of mortality of the F1 embryos. Interestingly, U exposure resulted in decreased circulating concentrations of vitellogenin in females. Increased concentrations of U were observed in gonads and eggs, which were most likely responsible for the genotoxic effects seen in fish gonads and in embryos exposed maternally to U. Altogether, these findings highlight the negative effect of environmentally relevant concentrations of U which alter the reproductive capability of fish and impair the genetic integrity of F1 embryos raising further concern regarding its effect at the population level. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. In situ observation of collagen thermal denaturation by second harmonic generation microscopy

    NASA Astrophysics Data System (ADS)

    Liao, C.-S.; Zhuo, Z.-Y.; Yu, J.-Y.; Chao, P.-H. G.; Chu, S.-W.

    2010-02-01

    Collagen denaturation is of fundamental importance for clinical treatment. Conventionally, the denaturation process is quantified by the shrinkage of collagen fibers, but the underlying molecular origin has not been fully understood. Since second harmonic generation (SHG) is related to the molecular packing of the triple helix in collagen fibers, this nonlinear signal provides an insight of molecular dynamics during thermal denaturation. With the aid of SHG microscopy, we found a new step in collagen thermal denaturation process, de-crimp. During the de-crimp step, the characteristic crimp pattern of collagen fascicles disappeared due to the breakage of interconnecting bonds between collagen fibrils, while SHG intensity remained unchanged, suggesting the intactness of the triple helical molecules. At higher temperature, shrinkage is observed with strongly reduced SHG intensity, indicating denaturation at the molecular level.

  2. Spectroscopic observation of jet-cooled 2,5-dichlorobenzyl radical generated by corona discharge

    NASA Astrophysics Data System (ADS)

    Yi, Eun Hye; Yoon, Young Wook; Lee, Sang Kuk

    2014-07-01

    Vibronically excited but jet-cooled 2,5-dichlorobenzyl radical was generated from 2,5-dichlorotoluene precursor in a large excess of helium carrier gas, from which the visible vibronic emission spectrum was recorded. From an analysis of the spectrum observed, it was found that the origin band shows larger shift to red than those expected from mono-substitutions, which has been discussed in terms of orientation of substituents. Also, the electronic energy of the D1 → D0 transition and vibrational mode frequencies at the ground electronic state of the 2,5-dichlorobenzyl radical were determined in comparison with the known vibrational data of precursor and ab initio calculations.

  3. Generation and Scattering of Radiation Observed by Voyager in the Outer Heliosphere

    NASA Technical Reports Server (NTRS)

    Spangler, Steven R.; Cairns, Iver H.

    2003-01-01

    Excellent progress was made under this grant on the generation and scattering of the 2-3 kHz radio emissions observed by the Voyager spacecraft in the outer heliosphere. These are the most powerful radio emissions produced in our solar system, surpassing even those of Jupiter and the Sun. The widely-held hypothesis pursued is that the radiation is generated near the electron plasma frequency f(sub p) or near 2f(sub p) as a shock wave traverses the heliosheath regions and/or heliopause predicted in the interaction region between the solar wind and the local interstellar medium. (Note that f (sup 2) (sub p) is proportional to the plasma density.) The traveling shock wave is plausibly associated with a global merged interaction region (GMIR). Accordingly, this so-called GMIR model is strongly analogous to the common interpretation of type II solar radio bursts and to radio emissions associated with Earth's bow shock, with coronal mass ejections (CMEs) and Earth's magnetosphere playing the role of a GMIR, respectively. Accordingly, Dr Cairns work on type II bursts, Earth's foreshock, and stochastic growth theory (not described in detail) strongly aided and complemented the research progress on the 2-3 kHz emissions described.

  4. Generation-X: An X-ray observatory designed to observe first light objects

    NASA Astrophysics Data System (ADS)

    Windhorst, Rogier A.; Cameron, R. A.; Brissenden, R. J.; Elvis, M. S.; Fabbiano, G.; Gorenstein, P.; Reid, P. B.; Schwartz, D. A.; Bautz, M. W.; Figueroa-Feliciano, E.; Petre, R.; White, N. E.; Zhang, W. W.

    2006-03-01

    The new cosmological frontier will be the study of the very first stars, galaxies and black holes in the early Universe. These objects are invisible to the current generation of X-ray telescopes, such as Chandra. In response, the Generation-X ("Gen-X") Vision Mission has been proposed as a future X-ray observatory which will be capable of detecting the earliest objects. X-ray imaging and spectroscopy of such faint objects demands a large collecting area and high angular resolution. The Gen-X mission plans 100 m 2 collecting area at 1 keV (1000× that of Chandra), and with an angular resolution of 0.1″. The Gen-X mission will operate at Sun-Earth L2, and might involve four 8 m diameter telescopes or even a single 20 m diameter telescope. To achieve the required effective area with reasonable mass, very lightweight grazing incidence X-ray optics must be developed, having an areal density 100× lower than in Chandra, with mirrors as thin as 0.1 mm requiring active on-orbit figure control. The suite of available detectors for Gen-X should include a large-area high resolution imager, a cryogenic imaging spectrometer, and a grating spectrometer. We discuss use of Gen-X to observe the birth of the first black holes, stars and galaxies, and trace their cosmic evolution.

  5. NeXOS, developing and evaluating a new generation of insitu ocean observation systems.

    NASA Astrophysics Data System (ADS)

    Delory, Eric; del Rio, Joaquin; Golmen, Lars; Roar Hareide, Nils; Pearlman, Jay; Rolin, Jean-Francois; Waldmann, Christoph; Zielinski, Oliver

    2017-04-01

    Ocean biological, chemical or physical processes occur over widely varying scales in space and time: from micro- to kilometer scales, from less than seconds to centuries. While space systems supply important data and information, insitu data is necessary for comprehensive modeling and forecasting of ocean dynamics. Yet, collection of in-situ observation on these scales is inherently challenging and remains generally difficult and costly in time and resources. This paper address the innovations and significant developments for a new generation of insitu sensors in FP7 European Union project "Next generation, Cost- effective, Compact, Multifunctional Web Enabled Ocean Sensor Systems Empowering Marine, Maritime and Fisheries Management" or "NeXOS" for short. Optical and acoustics sensors are the focus of NeXOS but NeXOS moves beyond just sensors as systems that simultaneously address multiple objectives and applications are becoming increasingly important. Thus NeXOS takes a perspective of both sensors and sensor systems with significant advantages over existing observing capabilities via the implementation of innovations such as multiplatform integration, greater reliability through better antifouling management and greater sensor and data interoperability through use of OGC standards. This presentation will address the sensor system development and field-testing of the new NeXOS sensor systems. This is being done on multiple platforms including profiling floats, gliders, ships, buoys and subsea stations. The implementation of a data system based on SWE and PUCK furthers interoperability across measurements and platforms. This presentation will review the sensor system capabilities, the status of field tests and recommendations for long-term ocean monitoring.

  6. Generation and effects of EMIC waves observed by the Van Allen Probes on 18 March 2013

    NASA Astrophysics Data System (ADS)

    Zhang, J.; Saikin, A.; Gamayunov, K. V.; Spence, H. E.; Larsen, B.; Geoffrey, R.; Smith, C. W.; Torbert, R. B.; Kurth, W. S.; Kletzing, C.

    2015-12-01

    Electromagnetic ion cyclotron (EMIC) waves play a crucial role in particle dynamics in the Earth's magnetosphere. The free energy for EMIC wave generation is usually provided by the temperature anisotropy of the energetic ring current ions. EMIC waves can in turn cause particle energization and losses through resonant wave-particle interactions. Using measurements from the Van Allen Probes, we perform a case study of EMIC waves and associated plasma conditions observed on 18 March 2013. From 0204 to 0211 UT, the Van Allen Probe-B detected He+-band EMIC wave activity in the post-midnight sector (MLT=4.6-4.9) at very low L-shells (L=2.6-2.9). The event occurred right outside the inward-pushed plasmapause in the early recovery phase of an intense geomagnetic storm - min. Dst = -132 nT at 2100 UT on 17 March 2013. During this event, the fluxes of energetic (> 1 keV), anisotropic O+ dominate both the H+ and He+ fluxes in this energy range. Meanwhile, O+ fluxes at low energies (< 0.1 keV) are low compared to H+ and He+ fluxes in the same energy range. The fluxes of <0.1 keV He+ are clearly enhanced during the wave event, indicating a signature of wave heating. To further confirm the association of the observed plasma features with the EMIC waves, we calculate the electron minimum resonant energy (Emin) and pitch angle diffusion coefficient (Dαα) of the EMIC wave packets by using nominal ion composition, derived total ion density from the frequencies of upper hybrid resonance, and measured ambient and wave magnetic field. EMIC wave growth rates are also calculated to evaluate the role of loss-cone distributed ring current ions in the EMIC wave generation.

  7. Retrospective analysis showing the water method increased adenoma detection rate — a hypothesis generating observation

    PubMed Central

    Leung, Joseph W; Do, Lynne D; Siao-Salera, Rodelei M; Ngo, Catherine; Parikh, Dhavan A; Mann, Surinder K

    2011-01-01

    Background A water method developed to attenuate discomfort during colonoscopy enhanced cecal intubation in unsedated patients. Serendipitously a numerically increased adenoma detection rate (ADR) was noted. Objective To explore databases of sedated patients examined by the air and water methods to identify hypothesis-generating findings. Design: Retrospective analysis. Setting: VA endoscopy center. Patients: creening colonoscopy. Interventions: From 1/2000–6/2006 the air method was used - judicious air insufflation to permit visualization of the lumen to aid colonoscope insertion and water spray for washing mucosal surfaces. From 6/2006–11/2009 the water method was adopted - warm water infusion in lieu of air insufflation and suction removal of residual air to aid colonoscope insertion. During colonoscope withdrawal adequate air was insufflated to distend the colonic lumen for inspection, biopsy and polypectomy in a similar fashion in both periods. Main outcome measurements: ADR. Results The air (n=683) vs. water (n=495) method comparisons revealed significant differences in overall ADR 26.8% (183 of 683) vs. 34.9% (173 of 495) and ADR of adenomas >9 mm, 7.2% vs. 13.7%, respectively (both P<0.05, Fisher's exact test). Limitations: Non-randomized data susceptible to bias by unmeasured parameters unrelated to the methods. Conclusion Confirmation of the serendipitous observation of an impact of the water method on ADR provides impetus to call for randomized controlled trials to test hypotheses related to the water method as an approach to improving adenoma detection. Because of recent concerns over missed lesions during colonoscopy, the provocative hypothesis-generating observations warrant presentation. PMID:21686105

  8. College 411: Get the Scoop. A Small Group Plan to Promote College Success for First-Generation College Students

    ERIC Educational Resources Information Center

    Land, Christy W.; Ziomek-Daigle, Jolie

    2013-01-01

    First generation college students have more difficulty preparing for and succeeding in post-secondary institutions. Informed by the literature review and relevant research the school counselor presents a small group design for high school students in their junior year. This small group plan for first generation college students addresses issues of…

  9. Borehole Temperature Observations Compared to Synthetic Subsurface Temperatures Generated by Proxy Climate Reconstructions

    NASA Astrophysics Data System (ADS)

    Huang, S.; Pollack, H. N.

    2002-12-01

    The array of proxy climate reconstructions for the Northern Hemisphere over the past millennium (Briffa and Osborn, Science 295, 2002) are all consistent in their representation of the 20th century warming, but diverge in their representations of the 11th through 19th centuries. The 'end-member' reconstructions of this array are represented by the MBH history (Mann, Bradley and Hughes, Geophys. Res. Lett. 26, 1999) which shows a slow cooling from 1000-1900, and the ECS history (Espers, Cook and Schweingruber, Science 295, 2002) which shows a net warming over much of that time interval. Temperature changes at the surface impose a downward-propagating thermal anomaly on the subsurface temperature field. Implicit in every proxy history of surface temperature is a subsurface temperature anomaly generated by the surface temperature model. We have calculated synthetic subsurface temperature anomalies for these 'end-member' proxy reconstructions, and compare the synthetic anomalies to borehole temperature observations. For this comparison we have selected 213 borehole sites, all logged in the 1990s and well-distributed longitudinally over the continents of the Northern Hemisphere. The synthetic subsurface temperature anomaly profile generated by the ECS reconstruction is close to the borehole observations, whereas the subsurface anomaly associated with the MBH reconstruction is significantly different. Because of its long multi-century cooling trend, the MBH model predicts a negative subsurface temperature anomaly below a depth of about 70m, a characteristic that is absent in both the ECS subsurface signature and in the borehole observations. We recognize that both the ECS reconstruction and the borehole temperatures are essentially extra-tropical records restricted to the continents, whereas the MBH reconstruction utilizes both tropical and extra-tropical data from both continents and oceans. However, to reconcile the significant difference between the negative

  10. 3D Spectrum of Equatorial Density Irregularities Generated from Observed 1D Spectra

    NASA Astrophysics Data System (ADS)

    Bust, G. S.; Rodrigues, F. S.; Psiake, M.; Kelley, M. C.; Roddy, P. A.

    2009-12-01

    ASTRA and Cornell University have a joint project underway to develop an inverse diffraction tomography algorithm suitable for a two-dimensional array of GPS receivers located in the equatorial region. A significant component of the research involves development of an accurate, realistic electro-magnetic propagation forward model that goes from the GPS satellites to the array of ground receivers. The forward model will be used to test the accuracy of the inverse diffraction tomography algorithm, help select the optimal method of doing the inversion, allow for comprehensive, sophisticated non-linear inversions, and help provide insight to the science that will result from the inversion analysis. The method of approach to the forward model includes a realistic 3D model of the electron density irregularities, arbitrary time-varying geometry between satellite and ground receiver array and multiple phase screens to allow for strong scattering. The focus of this talk is on the development of the 3D spectrum of the irregularities, and how the 3D spectrum can be generated from observed in-situ 1D spectra from rockets or satellites such C/NOFS. The C/NOFS satellite has an in-situ Plasma Langmuir Probe (PLP) sensor that is capable of measuring electron density fluctuations at sample rates of 512 Hz. Preliminary analysis has been performed on these fluctuations. Spectra have been calculated for a number of different altitudes and local times. Preliminary results are presented from this research and, assuming a power law form for the spectra, spectral indices are calculated. Given observed 1D spectra of the irregularities, a theoretical analysis will be presented that allows recovery of the 3D spectrum of irregularities from the observed 1D spectra. Preliminary calculations of such 3D spectra derived from the observed C/NOFS 1D spectra will be presented.

  11. Satellite observations of lightning-generated NOx in volcanic eruption clouds

    NASA Astrophysics Data System (ADS)

    Carn, Simon; Krotkov, Nickolay; Pickering, Ken; Allen, Dale; Bucsela, Eric

    2016-04-01

    The generation of NO2 by lightning flashes is known to be an important source of NOx in the free troposphere, particularly in the tropics, with implications for ozone production. Although UV-visible satellite observations of lightning-generated NOx (LNOx) in thunderstorms have been previously reported, here we present the first satellite observations of LNOx generated by lightning in explosive volcanic eruption clouds (vLNOx) from the Ozone Monitoring Instrument (OMI) aboard NASA's Aura satellite. To date we have identified vLNOx in operational OMI NO2 measurements (OMNO2) during the high-latitude eruptions of Okmok (Aleutian Is; July 2008), Kasatochi (Aleutian Is; August 2008), Redoubt (Alaska; March 2009) and Grimsvötn (Iceland; May 2011), although analysis of OMNO2 data for other eruptions is underway. We use World Wide Lightning Location Network (WWLLN) observations to verify the occurrence and location of lightning flashes in the volcanic eruption clouds. All the vLNOx anomalies are associated with strong UV Aerosol Index (UVAI) signals due to volcanic ash. Preliminary analysis shows that the maximum vLNOx column detected by OMI decreases linearly with time since eruption, and suggests that the vLNOx signal is transient and can be detected up to ~5-6 hours after an eruption. Detection of vLNOx is hence only possible for eruptions occurring a few hours before the daytime OMI overpass. Based on the number of lightning flashes detected by WWLLN in each eruption cloud, we also estimate the vLNOx production efficiency (moles vLNOx per flash). Preliminary estimates for the 2008 Kasatochi eruption suggest that this is significantly higher than the production efficiency in thunderstorms, but may be biased high due to the low detection efficiency of WWLLN (<10-50% of flashes detected over most regions). The measured vLNOx columns also require adjustment using an algorithm designed to retrieve LNOx from OMI, which takes the total OMI slant column NO2 and removes the

  12. Computational and experimental observations of welds in third-generation nickel-based superalloys

    NASA Astrophysics Data System (ADS)

    Naffakh-Moosavy, Homam

    2016-02-01

    The purpose of the present study is to introduce the weld quantitative solidification paths in the newly designed third-generation superalloys. The research has been conducted using both computational and experimental approaches. The model used the Scheil solidification relations to correlate the partitioning elements with their effects on the solidification paths. Accordingly, the k values were calculated for all the participating elements in the superalloy welds. The results of model demonstrated that these were very close to unity for austenite former elements, i.e. Ni, Co, Cr and Fe, while the other elements such as Ti, Nb and Mo displayed a significant tendency for segregation. The mathematical equations were calculated for weld solidification paths of superalloys. In all the welds, a remarkable segregation behaviour was observed, especially for Nb and Ti. The solidification path equations predicted type and amount of secondary phases. The solidification paths were compared with eutectic reactions ?, and ?, on the basis of the Ni-Ti-C and Ni-Nb-C ternary phase diagrams. Both the experimental measurements and microstructural observations of eutectics exhibited an appropriate accordance with the solidification paths obtained by model calculations.

  13. Sharing human-generated observations by integrating HMI and the Semantic Sensor Web.

    PubMed

    Sigüenza, Alvaro; Díaz-Pardo, David; Bernat, Jesús; Vancea, Vasile; Blanco, José Luis; Conejero, David; Gómez, Luis Hernández

    2012-01-01

    Current "Internet of Things" concepts point to a future where connected objects gather meaningful information about their environment and share it with other objects and people. In particular, objects embedding Human Machine Interaction (HMI), such as mobile devices and, increasingly, connected vehicles, home appliances, urban interactive infrastructures, etc., may not only be conceived as sources of sensor information, but, through interaction with their users, they can also produce highly valuable context-aware human-generated observations. We believe that the great promise offered by combining and sharing all of the different sources of information available can be realized through the integration of HMI and Semantic Sensor Web technologies. This paper presents a technological framework that harmonizes two of the most influential HMI and Sensor Web initiatives: the W3C's Multimodal Architecture and Interfaces (MMI) and the Open Geospatial Consortium (OGC) Sensor Web Enablement (SWE) with its semantic extension, respectively. Although the proposed framework is general enough to be applied in a variety of connected objects integrating HMI, a particular development is presented for a connected car scenario where drivers' observations about the traffic or their environment are shared across the Semantic Sensor Web. For implementation and evaluation purposes an on-board OSGi (Open Services Gateway Initiative) architecture was built, integrating several available HMI, Sensor Web and Semantic Web technologies. A technical performance test and a conceptual validation of the scenario with potential users are reported, with results suggesting the approach is sound.

  14. Direct observation of microcontact behaviours in pattern-generation step of reverse offset printing

    NASA Astrophysics Data System (ADS)

    Kusaka, Yasuyuki; Kanazawa, Shusuke; Yamamoto, Noritaka; Ushijima, Hirobumi

    2017-01-01

    In this study, we investigate the static and dynamic aspects of the nip formed during roll-to-sheet-type reverse offset printing. First, we show that several modes of roof collapses (bottom contact defects) could be formed depending on the poly(dimethylsiloxane) (PDMS) blanket thickness and pattern size. We regulate the manifestation of the defect modes driven by the local pile-up of the incompressible PDMS, as modelled by the contact mechanics formulation, together with a complementary numerical simulation. In dynamics, we first differentiate between the static nip and dynamic nip during printing, where the width is extended by the kinetically controlled adhesion of the blanket PDMS. Further, we observe that depending on the pattern structure, there was spatial deviation of the microscopic contact and subsequent separation behaviours of the cliché from a macroscopically recognizable nip, and consequently, local detachment rates were heterogeneous in the pattern-generation process of the reverse offset printing, even with a constant machine speed. In addition, we found that the parts of a pattern where the ink transfer fails in a high-speed patterning condition corresponded to the region of the locally enhanced detachment rates found during direct observation.

  15. Parenting styles in a cultural context: observations of "protective parenting" in first-generation Latinos.

    PubMed

    Domenech Rodríguez, Melanie M; Donovick, Melissa R; Crowley, Susan L

    2009-06-01

    Current literature presents four primary parenting styles: authoritative, authoritarian, permissive, and neglectful. These styles provide an important shortcut for a constellation of parenting behaviors that have been characterized as consisting of warmth, demandingness, and autonomy granting. Empirically, only warmth and demandingness are typically measured. Research reporting on parenting styles in Latino samples has been equivocal leading to questions about conceptualization and measurement of parenting styles in this ethnic/cultural group. This lack of consensus may result from the chasm between concepts (e.g., authoritarian parenting) and observable parenting behaviors (e.g., warmth) in this ethnic group. The present research aimed to examine parenting styles and dimensions in a sample of Latino parents using the two usual dimensions (warmth, demandingness) and adding autonomy granting. Traditional parenting styles categories were examined, as well as additional categorizations that resulted from adding autonomy granting. Fifty first-generation Latino parents and their child (aged 4-9) participated. Parent-child interactions were coded with the Parenting Style Observation Rating Scale (P-SOS). In this sample, the four traditional parenting categories did not capture Latino families well. The combination of characteristics resulted in eight possible parenting styles. Our data showed the majority (61%) of Latino parents as "protective parents." Further, while mothers and fathers were similar in their parenting styles, expectations were different for male and female children. The additional dimensions and implications are discussed. The importance of considering the cultural context in understanding parenting in Latino families is emphasized, along with directions for future research.

  16. Sharing Human-Generated Observations by Integrating HMI and the Semantic Sensor Web

    PubMed Central

    Sigüenza, Álvaro; Díaz-Pardo, David; Bernat, Jesús; Vancea, Vasile; Blanco, José Luis; Conejero, David; Gómez, Luis Hernández

    2012-01-01

    Current “Internet of Things” concepts point to a future where connected objects gather meaningful information about their environment and share it with other objects and people. In particular, objects embedding Human Machine Interaction (HMI), such as mobile devices and, increasingly, connected vehicles, home appliances, urban interactive infrastructures, etc., may not only be conceived as sources of sensor information, but, through interaction with their users, they can also produce highly valuable context-aware human-generated observations. We believe that the great promise offered by combining and sharing all of the different sources of information available can be realized through the integration of HMI and Semantic Sensor Web technologies. This paper presents a technological framework that harmonizes two of the most influential HMI and Sensor Web initiatives: the W3C's Multimodal Architecture and Interfaces (MMI) and the Open Geospatial Consortium (OGC) Sensor Web Enablement (SWE) with its semantic extension, respectively. Although the proposed framework is general enough to be applied in a variety of connected objects integrating HMI, a particular development is presented for a connected car scenario where drivers' observations about the traffic or their environment are shared across the Semantic Sensor Web. For implementation and evaluation purposes an on-board OSGi (Open Services Gateway Initiative) architecture was built, integrating several available HMI, Sensor Web and Semantic Web technologies. A technical performance test and a conceptual validation of the scenario with potential users are reported, with results suggesting the approach is sound. PMID:22778643

  17. ASTER and Ground Observations of Vegetation Primary Succession and Habitat Development near Retreating Glaciers in Alaska and Nepal

    NASA Astrophysics Data System (ADS)

    Kargel, J. S.; Leonard, G. J.; Furfaro, R.

    2011-12-01

    Like active volcanoes, glaciers are among the most dynamic components of the Earth's solid surface. All of the main surface processes active in these areas have an ability to suddenly remake or "resurface" the landscape, effectively wiping the land clean of vegetation and habitats, and creating new land surface and aqueous niches for life to colonize and develop anew. This biological and geomorphological resurfacing may remove the soil or replace it with inorganic debris layers. The topographical, hydrological, and particle size-frequency characteristics of resurfaced deglaciated landscapes typically create a high density of distinctive, juxtaposed niches where differing plant communities may become established over time. The result is commonly a high floral and faunal diversity and fecundity of life habitats. The new diverse landscape continues to evolve rapidly as ice-cored moraines thaw, lakes drain or fill in with sediment, as fluvial dissection erodes moraine ridges, as deltaic sedimentation shifts, and other processes (coupled with primary succession) take place in rapid sequence. In addition, climate dynamics which may have caused the glaciers to retreat may continue. We will briefly explore two distinctive glacial environments-(1) the maritime Copper River corridor through the Chugach Mountains (Alaska), Allen Glacier, and the river's delta; and (2) Nepal's alpine Khumbu valley and Imja Glacier. We will provide an example showing how ASTER multispectral and stereo-derived elevation data, with some basic field-based constraints and observations, can be used to make automatic maps of certain habitats, including that of the Tibetan snowcock. We will examine geomorphic and climatic domains where plant communities are becoming established in the decades after glacier retreat and how these link to the snowcock habitat and range. Snowcock species have previously been considered to have evolved in close association with glacial and tectonic history of South and

  18. Lagrange Point Missions: the Key to Next-Generation Integrated Earth Observations. DSCOVR Innovation

    NASA Astrophysics Data System (ADS)

    Valero, F. P. J.

    2016-12-01

    From L-1 DSCOVR is capable of new, unique observations potentially conducive to a deeper scientific understanding of the Earth sciences. At L-1 and L-2 the net gravitational pull of the Earth and Sun equals the centripetal force required to orbit the Sun with the same period as the Earth. Satellites at or near L-1 and L-2 keep the same position relative to the Sun and the Earth. DSCOVR does not orbit the Earth but the Sun in synchronism with Earth, acts like a planetoid (orbits the Sun in the ecliptic plane) while acquiring integrated plus spatially and time resolved scientific data as Earth rotates around its axis. Because of the planet's axial tilt relative to the ecliptic plane, the Polar Regions are visible during local summer from L-1 and local winter from L-2 (Fig. 1). DSCOVR's synoptic and continuous observations solve most of the temporal and spatial limitations associated with low Earth (LEO) and Geostationary (GEO) orbits. Two observatories, one at L-1 (daytime) and one at L-2 (nighttime), would acquire minute-by-minute climate quality data for essentially every point on Earth. The integration of L-1, L-2, LEO, and GEO satellites plus the Moon offers new scientific tools and enriched data sets for Earth sciences. Lagrange points observatories are key to next-generation integrated Earth observations. For example, DSCOVR at L-1 views the Earth plus the Moon (a reference) and simultaneously, at one time or another, all LEO and GEO satellites. The L-1 and L-2 satellites would be the link between the Moon, LEO and GEO satellites while providing the data needed to build an integrated Earth observational system. The above properties are the bases for DSCOVR's innovation and scientific approach that systematically observes climate drivers (radiation, aerosols, ozone, clouds, water vapor, vegetation) from L-1 in a way not possible but synergistic with other satellites. Next step: more capable L-1 plus L-2 satellites. The way of the future.

  19. Identifying the Strengths, Needs, and Barriers to Student Success for First Generation, Low-Income, First Year College Students

    ERIC Educational Resources Information Center

    Hayes, Linda A.

    2013-01-01

    This participatory action research needs assessment was to empower the students in a large urban research university to explore and to identify the strengths of the program, to identify the needs, and to identify the barriers to student success during their first year of college. Using qualitative methods of Group Level Interviews (GLA) and…

  20. Boosting Post-Secondary and Career Success: A Two-Generation Approach for the Promise Neighborhood. Education

    ERIC Educational Resources Information Center

    Halbert, Hannah

    2014-01-01

    The Cleveland Central Promise Neighborhood (CCPN) initiative brings together Central neighborhood residents, community stakeholders and partners to create the kind of community where every child can have career and college success. Helping children achieve a bright future filled with opportunity is the cornerstone of the Promise Initiative. The…

  1. Boosting Post-Secondary and Career Success: A Two-Generation Approach for the Promise Neighborhood. Education. Executive Summary

    ERIC Educational Resources Information Center

    Halbert, Hannah

    2014-01-01

    The Cleveland Central Promise Neighborhood (CCPN) initiative brings together Central neighborhood residents, community stakeholders and partners to create the kind of community where every child can have career and college success. Helping children achieve a bright future filled with opportunity is the cornerstone of the Promise Initiative. The…

  2. Succession Planning in Homeland Security - How Can We Ensure the Effective Transfer of Knowledge to a New Generation of Employees

    DTIC Science & Technology

    2010-03-01

    Postgraduate School. Brafman, O., & Beckstrom, R. A. (2006). The starfish and the spider : The unstoppable power of leaderless organizations. New York... Wolfe , R. L. (1996). Systematic succession planning: Building leadership from within. Menlo Park, CA: Crisp Publications. Zemke, R., Raines, C

  3. Pedigree analysis reveals a generational decline in reproductive success of captive Tasmanian devil (Sarcophilus harrisii): implications for captive management of threatened species.

    PubMed

    Farquharson, Katherine A; Hogg, Carolyn J; Grueber, Catherine E

    2017-04-04

    Captive breeding programs are an increasingly popular tool to augment the conservation of threatened wild populations. Many programs keep detailed pedigrees, which are used to prescribe breeding targets to meet demographic and genetic goals. Annual breeding targets are based on previous productivity, but do not account for changes in reproductive success that may occur over generations in captivity and which may impair the ability of a program to meet its goals. We utilise a large studbook from the Tasmanian devil (Sarcophilus harrisii) captive breeding program to investigate biological, genetic and environmental factors that affect variation in reproductive success among individuals and over generations of captive breeding. Reproductive success declined with increasing generations in captivity: wild-born females had a 56.5% chance of producing a litter compared to a 2.8% chance for generation 5 captive-born females (N = 182) and when they did, wild-born females produced more offspring (3.1 joeys, 95% CI: 2.76 - 3.38, compared to 2.7 joeys, 95% CI: 2.55 - 2.90, in captive-born females [N = 105]). Reproductive success also declined as dam age at first breeding increased. Our results reveal a conflict with the widely-cited conservation strategy to limit opportunity for selection by extending generation length through delaying reproduction, as captive breeding programs that delay female breeding with this goal in mind risk reduced productivity. Our data demonstrate the benefit of pedigree analysis to identify biological processes that reveal crucial trade-offs with conservation best-practice.

  4. Continuous rainfall generation for a warmer climate using observed temperature sensitivities

    NASA Astrophysics Data System (ADS)

    Wasko, Conrad; Sharma, Ashish

    2017-01-01

    Continuous rainfall sequences are often used as inputs in hydrologic modeling, particularly where a probabilistic assessment is required. Continuous rainfall sequences provide a means for accounting of all aspects of rainfall that produce flooding, for example, not just the design rainfall event but also the rainfall prior to the extreme rainfall event. With the advent of climate change, higher temperatures have been associated with changes in rainfall, in particular intensifying rainfall extremes with less uniform temporal patterns. Given these demonstrated changes to extreme rainfall with temperature rise, there is a need to modify continuous rainfall generators to account for current and likely future changes in temperature. In this work we propose a novel method for simulating continuous rainfall sequences for a future warmer climate by conditioning parameters on their historical sensitivity with temperature. To demonstrate the proposed technique we use a one-dimensional Neyman-Scott Rectangular Pulses model at two locations across Australia. The statistics used in the parameter estimation are conditioned on their historical sensitivity to average monthly temperature to simulate rainfall for a change in temperature. The results are validated by comparing the simulated rainfall against observations originating from differing temperatures and it is shown that the model captures the relative difference in the mean monthly rainfall and monthly maxima. Encouraged by these results we simulate rainfall for higher temperatures and capture expected changes to annual maxima and design temporal patterns for a warmer climate. While we demonstrate our methodology in the simulation of sub-daily rainfall using a specific model, the approach presented here can be applied to all weather generation schemes for projection in a warmer climate.

  5. Field observations of slush ice generated during freeze-up in arctic coastal waters

    USGS Publications Warehouse

    Reimnitz, E.; Kempema, E.W.

    1987-01-01

    In some years, large volumes of slush ice charged with sediment are generated from frazil crystals in the shallow Beaufort Sea during strong storms at the time of freeze-up. Such events terminate the navigation season, and because of accompanying hostile conditions, little is known about the processes acting. The water-saturated slush ice, which may reach a thickness of 4 m, exists for only a few days before freezing from the surface downward arrests further wave motion or pancake ice forms. Movements of small vessels and divers in the slush ice occurs only in phase with passing waves, producing compression and rarefaction, and internal pressure pulses. Where in contact with the seafloor, the agitated slush ice moves cobble-size material, generates large sediment ripples, and may possibly produce a flat rampart observed on the arctic shoreface in some years. Processes charging the slush ice with as much as 1000 m3 km-2 of sediment remain uncertain, but our field observations rule out previously proposed filtration from turbid waters as a likely mechanism. Sedimentary particles apparently are only trapped in the interstices of the slush ice rather than being held by adhesion, since wave-related internal pressure oscillations result in downward particle movement and cleansing of the slush ice. This loss of sediment explains the typical downward increase in sediment concentration in that part of the fast-ice canopy composed largely of frazil ice. The congealing slush ice in coastal water does not become fast ice until grounded ridges are formed in the stamukhi zone, one to two months after freeze-up begins. During this period of new-ice mobility, long-range sediment transport occurs. The sediment load held by the fast-ice canopy in the area between the Colville and Sagavanirktok River deltas in the winter of 1978-1979 was 16 times larger than the yearly river input to the same area. This sediment most likely was rafted from Canada, more than 400 km to the east, during

  6. Multicenter Observational Study of the First-Generation Intravenous Blood Glucose Monitoring System in Hospitalized Patients

    PubMed Central

    Bochicchio, Grant V.; Hipszer, Brian R.; Magee, Michelle F.; Bergenstal, Richard M.; Furnary, Anthony P.; Gulino, Angela M.; Higgins, Michael J.; Simpson, Peter C.; Joseph, Jeffrey I.

    2015-01-01

    Background: Current methods of blood glucose (BG) monitoring and insulin delivery are labor intensive and commonly fail to achieve the desired level of BG control. There is great clinical need in the hospital for a user-friendly bedside device that can automatically monitor the concentration of BG safely, accurately, frequently, and reliably. Methods: A 100-patient observation study was conducted at 6 US hospitals to evaluate the first generation of the Intravenous Blood Glucose (IVBG) System (Edwards Lifesciences LLC & Dexcom Inc). Device safety, accuracy, and reliability were assessed. A research nurse sampled blood from a vascular catheter every 4 hours for ≤ 72 hours and BG concentration was measured using the YSI 2300 STAT Plus Analyzer (YSI Life Sciences). The IVBG measurements were compared to YSI measurements to calculate point accuracy. Results: The IVBG systems logged more than 5500 hours of operation in 100 critical care patients without causing infection or inflammation of a vein. A total of 44135 IVBG measurements were performed in 100 patients with 30231 measurements from the subset of 75 patients used for accuracy analysis. In all, 996 IVBG measurements were time-matched with reference YSI measurements. These pairs had a mean absolute difference (MAD) of 11.61 mg/dl, a mean absolute relative difference (MARD) of 8.23%, 93% met 15/20% accuracy defined by International Organization for Standardization 15197:2003 standard, and 93.2% were in zone A of the Clarke error grid. The IVBG sensors were exposed to more than 200 different medications with no observable effect on accuracy. Conclusions: The IVBG system is an automated and user-friendly glucose monitoring system that provides accurate and frequent BG measurements with great potential to improve the safety and efficacy of insulin therapy and BG control in the hospital, potentially leading to improved clinical outcomes. PMID:26033922

  7. Three-Centimeter Doppler Radar Observations of Wingtip-Generated Wake Vortices in Clear Air

    NASA Technical Reports Server (NTRS)

    Marshall, Robert E.; Mudukutore, Ashok; Wissel, Vicki L. H.; Myers, Theodore

    1997-01-01

    This report documents a high risk, high pay-off experiment with the objective of detecting, for the first time, the presence of aircraft wake vortices in clear air using X-band Doppler radar. Field experiments were conducted in January 1995 at the Wallops Flight Facility (WFF) to demonstrate the capability of the 9.33 GHz (I=3 cm) radar, which was assembled using an existing nine-meter parabolic antenna reflector at VVTT and the receiver/transmitter from the NASA Airborne Windshear Radar-Program. A C-130-aircraft, equipped with wingtip smoke generators, created visually marked wake vortices, which were recorded by video cameras. A C-band radar also observed the wake vortices during detection attempts with the X-band radar. Rawinsonde data was used to calculate vertical soundings of wake vortex decay time, cross aircraft bearing wind speed, and water vapor mixing ratio for aircraft passes over the radar measurement range. This experiment was a pathfinder in predicting, in real time, the location and persistence of C-130 vortices, and in setting the flight path of the aircraft to optimize X-band radar measurement of the wake vortex core in real time. This experiment was conducted in support of the NASA Aircraft Vortex Spacing System (AVOSS).

  8. Numerical simulation of convectively generated gravity waves in West Africa and comparisons with observations

    NASA Astrophysics Data System (ADS)

    Heinrich, P.; Blanc, E.

    2012-04-01

    Convective clouds in the ITCZ (Intertropical Convergence Zone) are a major source of nonstationary gravity waves, that propagate to the stratosphere and result in upward displacements at low levels, which induces new convection. Simulations of wind fields are performed by the mesoscale meteorological model WRF (Advanced Research Weather Research and Forecasting) over a period of 2 days during active thunderstorm days. Simulations are carried out in a domain covering the ITCZ in West Africa using 2 nested grids with horizontal grid spacing of 27 and 9 km respectively. Simulations are driven by ECMWF winds (defined by 91 levels from surface to 80 km), using 100 levels from surface to 50 Pa and a sponge layer above 45 km. The waves characteristics are compared to observations at the CTBT (Comprehensive Test Ban Treaty) infrasound station in Ivory Coast. The aim of this study is to further understand the mechanisms of wave generation by deep convection and propagation to the stratosphere. In a second part, we also study the effects of gravity waves on the dynamics of the tropical atmosphere and perform sensitivity simulations to the top height of the model.

  9. In-situ Observations of Eddy Generation from a Meandering Jet in the Kuroshio Extension

    NASA Astrophysics Data System (ADS)

    Johnson, L.; Lee, C.; D'Asaro, E. A.

    2016-12-01

    This study utilizes observations that follow a finite amplitude meander of the Kuroshio Extension before it separates to form a cyclonic cold core ring. A neutrally buoyant, subsurface Lagrangian float was deployed in center of the meandering jet as a part of the Office of Naval Research Assessing the Effect of Submesoscale Ocean Parameterizations (AESOP) program. The float's trajectory was acoustically tracked for three days, allowing the region surrounding the drifting float to be intensely surveyed by a ship towing a Triaxus undulating profiler. The survey provided a time series of eleven high-resolution cross sections sampling the velocity and scalar fields surrounding the float to a depth of 250m. Isopycnals along the front are steep initially and outline the doming of the eddy core. As the meander develops, the isopycnals cave inward as warm salty water outside the meander slide on top of cooler, fresher water in the core, causing the regions above and around the eddy to stratify. Southeasterly winds were persistent across the meander throughout the duration of the survey, inducing an Ekman transport with spatially varying restratification and destratification across the developing eddy. Ageostrophic flows along with asymmetries in the flow field are used to discuss the evolution and distribution of heat and salt within and around the eddy core with implications for our understanding of mesoscale eddy generation.

  10. Observations of wind-generated waves on variable current. [laboratory ocean dynamics for water wave generator research

    NASA Technical Reports Server (NTRS)

    Long, S. R.; Huang, N. E.

    1976-01-01

    Laboratory measurements utilizing a laser probe are made for the slopes of wind waves generated on both positive and negative currents at different values of fetch. The data are then processed electronically to yield an average wave-slope spectrum in frequency space with 128 degrees of freedom. These spectra are used to obtain the growth of the spectral components at various frequency bands for increasing wind and different values of fetch and current. The results indicate that the growth of these components is not monotonic with the frictional wind speed, but rather exhibits an 'overshoot' phenomena at lower values of frictional wind speed, and in addition, displays a significant effect due to current. The peak location and spectral intensity of the spectra also show strong influence by the current condition. This results in the rms surface slope value increasing with negative current and decreasing with positive current. The results agree qualitatively with some theoretical predictions. The potential use of the current-induced effects as a means for remote sensing of ocean current is also briefly discussed.

  11. Observations of wind-generated waves on variable current. [laboratory ocean dynamics for water wave generator research

    NASA Technical Reports Server (NTRS)

    Long, S. R.; Huang, N. E.

    1976-01-01

    Laboratory measurements utilizing a laser probe are made for the slopes of wind waves generated on both positive and negative currents at different values of fetch. The data are then processed electronically to yield an average wave-slope spectrum in frequency space with 128 degrees of freedom. These spectra are used to obtain the growth of the spectral components at various frequency bands for increasing wind and different values of fetch and current. The results indicate that the growth of these components is not monotonic with the frictional wind speed, but rather exhibits an 'overshoot' phenomena at lower values of frictional wind speed, and in addition, displays a significant effect due to current. The peak location and spectral intensity of the spectra also show strong influence by the current condition. This results in the rms surface slope value increasing with negative current and decreasing with positive current. The results agree qualitatively with some theoretical predictions. The potential use of the current-induced effects as a means for remote sensing of ocean current is also briefly discussed.

  12. First-Generation Social and Ethnic Minority Students in Christian Universities: Student Recommendations for Successful Support of Diverse Students

    ERIC Educational Resources Information Center

    Ecklund, Kathryn

    2013-01-01

    This article, the second in a two-part series, provides an overview of the literature regarding first-generation college students (FGCS), which has been largely based on studies of students in public universities. The author shares outcomes from structured dialogues with FGCS attending Christian universities. The students described how their…

  13. A Continuum of Persistence: Low-Income and First-Generation College Students' Perceptions of Critical Factors for Postsecondary Success

    ERIC Educational Resources Information Center

    Ganuza Hoaglund, Zoila M.

    2014-01-01

    The purpose of this study was to explore similarities and differences among low-income and first-generation (LIFG) students' perceptions of influential academic, psychosocial, and contextual factors that shaped their persistence at different stages at the postsecondary level. This study consisted of 29 LIFG students from a large, urban research…

  14. Relationship between Academic Resilience and College Success: Cross-National Experiences of Low-Income/First-Generation Students

    ERIC Educational Resources Information Center

    Mbindyo, Margaret N.

    2011-01-01

    The present study examines the relationship between academic resilience (defined as the ability to effectively deal with setbacks, stress, or pressure in an academic setting) and the experiences of US students served by TRIO intervention programs (federally funded programs) that serve low-income/first-generation students. Based on a sample of 106,…

  15. Deep Structure and Earthquake Generating Properties in the Yamasaki Fault Zone Estimated from Dense Seismic Observation

    NASA Astrophysics Data System (ADS)

    Nishigami, K.; Shibutani, T.; Katao, H.; Yamaguchi, S.; Mamada, Y.

    2010-12-01

    We have been estimating crustal heterogeneous structure and earthquake generating properties in and around the Yamasaki fault zone, which is a left-lateral strike-slip active fault with a total length of about 80 km in southwest Japan. We deployed dense seismic observation network, composed of 32 stations with average spacing of 5-10 km around the Yamasaki fault zone. We estimate detailed fault structure such as fault dip and shape, segmentation, and possible location of asperities and rupture initiation point, as well as generating properties of earthquakes in the fault zone, through analyses of accurate hypocenter distribution, focal mechanism, 3-D velocity tomography, coda wave inversion, and other waveform analyses. We also deployed a linear seismic array across the fault, composed of 20 stations with about 20 m spacing, in order to delineate the fault-zone structure in more detail using the seismic waves trapped inside the low velocity zone. We also estimate detailed resistivity structure at shallow depth of the fault zone by AMT (audio-frequency magnetotelluric) and MT surveys. In the scattering analysis of coda waves, we used 2,391 wave traces from 121 earthquakes that occurred in 2002, 2003, 2008 and 2009, recorded at 60 stations, including dense temporary and routine stations. We estimated 3-D distribution of relative scattering coefficients along the Yamasaki fault zone. Microseismicity is high and scattering coefficient is relatively larger in the upper crust along the entire fault zone. The distribution of strong scatterers suggests that the Ohara and Hijima faults, which are the segments in the northwestern part of the Yamasaki fault zone, have almost vertical fault plane from surface to a depth of about 15 km. We used seismic network data operated by Universities, NIED, AIST, and JMA. This study has been carried out as a part of the project "Study on evaluation of earthquake source faults based on surveys of inland active faults" by Japan Nuclear

  16. Testing predictions of forest succession using long-term measurements: 100 yrs of observations in the Oregon Cascades

    Treesearch

    Mark E. Harmon; Robert J. Pabst

    2015-01-01

    Question: Many predictions about forest succession have been based on chronosequences. Are these predictions – at the population, community and ecosystemlevel – consistent with long-termmeasurements in permanent plots? Location: Pseudotsuga menziesii (Mirb.) Franco dominated forest in western Oregon, US.Methods: Over a 100-yr period,...

  17. Generations.

    PubMed

    Chambers, David W

    2005-01-01

    Groups naturally promote their strengths and prefer values and rules that give them an identity and an advantage. This shows up as generational tensions across cohorts who share common experiences, including common elders. Dramatic cultural events in America since 1925 can help create an understanding of the differing value structures of the Silents, the Boomers, Gen Xers, and the Millennials. Differences in how these generations see motivation and values, fundamental reality, relations with others, and work are presented, as are some applications of these differences to the dental profession.

  18. Generation of real-time mode high-resolution water vapor fields from GPS observations

    NASA Astrophysics Data System (ADS)

    Yu, Chen; Penna, Nigel T.; Li, Zhenhong

    2017-02-01

    Pointwise GPS measurements of tropospheric zenith total delay can be interpolated to provide high-resolution water vapor maps which may be used for correcting synthetic aperture radar images, for numeral weather prediction, and for correcting Network Real-time Kinematic GPS observations. Several previous studies have addressed the importance of the elevation dependency of water vapor, but it is often a challenge to separate elevation-dependent tropospheric delays from turbulent components. In this paper, we present an iterative tropospheric decomposition interpolation model that decouples the elevation and turbulent tropospheric delay components. For a 150 km × 150 km California study region, we estimate real-time mode zenith total delays at 41 GPS stations over 1 year by using the precise point positioning technique and demonstrate that the decoupled interpolation model generates improved high-resolution tropospheric delay maps compared with previous tropospheric turbulence- and elevation-dependent models. Cross validation of the GPS zenith total delays yields an RMS error of 4.6 mm with the decoupled interpolation model, compared with 8.4 mm with the previous model. On converting the GPS zenith wet delays to precipitable water vapor and interpolating to 1 km grid cells across the region, validations with the Moderate Resolution Imaging Spectroradiometer near-IR water vapor product show 1.7 mm RMS differences by using the decoupled model, compared with 2.0 mm for the previous interpolation model. Such results are obtained without differencing the tropospheric delays or water vapor estimates in time or space, while the errors are similar over flat and mountainous terrains, as well as for both inland and coastal areas.

  19. Sentinel-2: next generation satellites for optical land observation from space

    NASA Astrophysics Data System (ADS)

    Lautenschläger, G.; Gessner, R.; Gockel, W.; Haas, C.; Schweickert, G.; Bursch, S.; Welsch, M.; Sontag, H.

    2013-10-01

    The first Sentinel-2 satellites, which constitute the next generation of operational Earth observation satellites for optical land monitoring from space, are undergoing completion in the facilities at Astrium ready for launch end 2014. Sentinel-2 will feature a major breakthrough in the area of optical land observation since it will for the first time enable continuous and systematic acquisition of all land surfaces world-wide with the Multi-Spectral Instrument (MSI), thus providing the basis for a truly operational service. Flying in the same orbital plane and spaced at 180°, the constellation of two satellites, designed for an in-orbit nominal operational lifetime of 7 years each, will acquire all land surfaces in only 5 days at the equator. In order to support emergency operations, the satellites can further be operated in an extended observation mode allowing to image any point on Earth even on a daily basis. MSI acquires images in 13 spectral channels from Visible-to-Near Infrared (VNIR) to Short Wave Infrared (SWIR) with a swath of almost 300 km on ground and a spatial resolution up to 10 m. The data ensure continuity to the existing data sets produced by the series of Landsat and SPOT satellites, and will further provide detailed spectral information to enable derivation of biophysical or geophysical products. Excellent geometric image quality performances are achieved with geolocation better than 16 m, thanks to an innovative instrument design in conjunction with a high-performance satellite AOCS subsystem centered around a 2-band GPS receiver, high-performance star trackers and a fiberoptic gyro. To cope with the high data volume on-board, data are compressed using a state-of-the-art wavelet compression scheme. Thanks to a powerful mission data handling system built around a newly developed very large solid-state mass memory based on flash technology, on-board compression losses will be kept to a minimum. The Sentinel-2 satellite design features a highly

  20. Generation mechanism of the slowly drifting narrowband structure in the type IV solar radio bursts observed by AMATERAS

    SciTech Connect

    Katoh, Y.; Nishimura, Y.; Kumamoto, A.; Ono, T.; Iwai, K.; Misawa, H.; Tsuchiya, F.

    2014-05-20

    We investigate the type IV burst event observed by AMATERAS on 2011 June 7, and reveal that the main component of the burst was emitted from the plasmoid eruption identified in the EUV images of the Solar Dynamics Observatory (SDO)/AIA. We show that a slowly drifting narrowband structure (SDNS) appeared in the burst's spectra. Using statistical analysis, we reveal that the SDNS appeared for a duration of tens to hundreds of milliseconds and had a typical bandwidth of 3 MHz. To explain the mechanism generating the SDNS, we propose wave-wave coupling between Langmuir waves and whistler-mode chorus emissions generated in a post-flare loop, which were inferred from the similarities in the plasma environments of a post-flare loop and the equatorial region of Earth's inner magnetosphere. We assume that a chorus element with a rising tone is generated at the top of a post-flare loop. Using the magnetic field and plasma density models, we quantitatively estimate the expected duration of radio emissions generated from coupling between Langmuir waves and chorus emissions during their propagation in the post-flare loop, and we find that the observed duration and bandwidth properties of the SDNS are consistently explained by the proposed generation mechanism. While observations in the terrestrial magnetosphere show that the chorus emissions are a group of large-amplitude wave elements generated naturally and intermittently, the mechanism proposed in the present study can explain both the intermittency and the frequency drift in the observed spectra.

  1. Successful differentiation to T cells, but unsuccessful B-cell generation, from B-cell-derived induced pluripotent stem cells.

    PubMed

    Wada, Haruka; Kojo, Satoshi; Kusama, Chie; Okamoto, Naoki; Sato, Yorino; Ishizuka, Bunpei; Seino, Ken-ichiro

    2011-01-01

    Forced expression of certain transcription factors in somatic cells results in generation of induced pluripotent stem (iPS) cells, which differentiate into various cell types. We investigated T-cell and B-cell lineage differentiation from iPS cells in vitro. To evaluate the impact of iPS cell source, murine splenic B-cell-derived iPS (B-iPS) cells were generated after retroviral transduction of four transcription factors (Oct4, Sox2, Klf4 and c-Myc). B-iPS cells were identical to embryonic stem (ES) cells and mouse embryonic fibroblast (MEF)-derived iPS cells in morphology, ES cell marker expression as well as teratoma and chimera mouse formation. Both B-iPS and MEF-derived iPS cells differentiated into lymphocytes in OP9 co-culture systems. Both efficiently differentiated into T-cell lineage that produced IFN-γ on T-cell receptor stimulation. However, iPS cells including B-iPS cells were relatively resistant to B-cell lineage differentiation. One of the reasons of the failure of B-cell lineage differentiation seemed due to a defect of Pax5 expression in the differentiated cells. Therefore, current in vitro differentiation systems using iPS cells are sufficient for inducing T-cell but not B-cell lineage.

  2. Long-term dental implant success and survival--a clinical study after an observation period up to 6 years.

    PubMed

    Charyeva, Olga; Altynbekov, Kubeysin; Zhartybaev, Rahmed; Sabdanaliev, Asylbek

    2012-01-01

    The aim of the present work was to evaluate the long-term results of dental implants and the risk factors associated with implant survival and success rates. 108 patients were examined and the control consisted of medical history taking, clinical and radiographic examinations. The survival rate of dental implants was 96.0% and the success rate was 94.3%. Mucositis was found to be related to patients' age and the number of implant units placed. Peri-implantitis was often found in patients showing low standards of oral hygiene as well as in those who were not coming on regular dental visits. Mucositis was in every 5th implant site and was mostly seen in patients with prosthetic constructions consisting of 3 or more units as well as in older patients. Oral hygiene and dental control visits are important to maintain good oral health.

  3. Seizures induced by desloratadine, a second-generation antihistamine: clinical observations.

    PubMed

    Cerminara, Caterina; El-Malhany, Nadia; Roberto, Denis; Lo Castro, Adriana; Curatolo, Paolo

    2013-08-01

    Some clinical experiences indicate that H1-antihistamines, especially first-generation H1-antagonists, occasionally provoke convulsions in healthy children as well as epileptic patients. Desloratadine is a frequently used second-generation antihistamine considered to be effective and safe for the treatment of allergic diseases. We describe four children who experienced epilepsy associated with the nonsedating H(1)-antagonist desloratadine and discuss the neurophysiologic role of the central histaminergic system in seizure susceptibility. In conclusion, we recommend caution in treating epileptic patients with the histamine H(1)-antagonists, including second- and third-generation drugs that are frequently referred because they are considered to be nonsedating antihistamines.

  4. Using ground-level cosmic ray observations for automatically generating predictions of hazardous energetic particle levels

    NASA Astrophysics Data System (ADS)

    Dorman, Lev; Pustil'Nik, Lev; Sternlieb, Abraham; Zukerman, Igor

    It is well known that in periods of great flare energetic particle (FEP) ground events, fluxes of energetic particles can be so big that memory of computers and other electronics in space may be damaged, and satellite and spacecraft operations can be seriously degraded. In these periods it is necessary to switch off some part of electronics for a few hours to protect computer memories. The problem is how to forecast exactly these dangerous phenomena. We show that exact forecasts can be made by using high-energy particles (few GeV/nucleon and higher) whose transportation from the Sun is characterized by much bigger diffusion coefficients than lower energy particles. High-energy particles arrive from the Sun much earlier (8-20 minutes after acceleration and escaping into solar wind) than the lower energy particles that damage electronics (about 30-60 minutes later). We describe here the principles and operation of automated programs ``FEP-Search-1 min'', ``FEP-Search-2 min'',and ``FEPSearch-5 min'', developed and checked in the Emilio Segre' Observatory (ESO) of the Israel Cosmic Ray Center (2025 m above sea level, Rc =10.8 GV). The determination of increasing flux is made by comparison with the intensity, averaged from 120 to 61 minutes, prior to the current one-minute data. For each minute of data the program ``FEP-Search-1 min'' is run. If the result is negative (no simultaneous increase in both channels of total intensity >= 2.5 σ1, where σ1 is the standard deviation for one minute of observation in one channel [for ESO σ1=1.4 %), start the program ``FEP-Search-2 min'', using two minute averages with σ2 = σ1 /√2, and so on. If any positive result is obtained, the ``FEP-Search'' programs check the next minute of data. If the result is again positive, automatically run the on-line the programs ``FEP-Collect'' and ``FEP-Research'' that determine the expected flux and spectrum and generate automatic alerts. These programs are described in Dorman and Zukerman

  5. Variance Analysis of Wind and Natural Gas Generation under Different Market Structures: Some Observations

    SciTech Connect

    Bush, B.; Jenkin, T.; Lipowicz, D.; Arent, D. J.; Cooke, R.

    2012-01-01

    Does large scale penetration of renewable generation such as wind and solar power pose economic and operational burdens on the electricity system? A number of studies have pointed to the potential benefits of renewable generation as a hedge against the volatility and potential escalation of fossil fuel prices. Research also suggests that the lack of correlation of renewable energy costs with fossil fuel prices means that adding large amounts of wind or solar generation may also reduce the volatility of system-wide electricity costs. Such variance reduction of system costs may be of significant value to consumers due to risk aversion. The analysis in this report recognizes that the potential value of risk mitigation associated with wind generation and natural gas generation may depend on whether one considers the consumer's perspective or the investor's perspective and whether the market is regulated or deregulated. We analyze the risk and return trade-offs for wind and natural gas generation for deregulated markets based on hourly prices and load over a 10-year period using historical data in the PJM Interconnection (PJM) from 1999 to 2008. Similar analysis is then simulated and evaluated for regulated markets under certain assumptions.

  6. Observation-Consistent Input and Whitecapping Dissipation in a Model for Wind-Generated Surface Waves: Description and Simple Calculations

    DTIC Science & Technology

    2012-09-01

    Oceanogr., 14,1271-1285. Longuet-Higgins, M. S., and R. W. Stewart, 1960: Changes in the form of short gravity waves on long waves and tidal currents...SEPTEMBER 2012 ROGERS ET AL. 1329 Observation-Consistent Input and Whitecapping Dissipation in a Model for Wind-Generated Surface Waves ...wind-input and wind-breaking dissipation for phase-averaged spectral models of wind-generated surface waves is presented. Both are based on recent

  7. Experimental observation of a magnetic-turbulence threshold for runaway-electron generation in the TEXTOR tokamak.

    PubMed

    Zeng, L; Koslowski, H R; Liang, Y; Lvovskiy, A; Lehnen, M; Nicolai, D; Pearson, J; Rack, M; Jaegers, H; Finken, K H; Wongrach, K; Xu, Y; Textor Team

    2013-06-07

    Magnetic turbulence is observed at the beginning of the current quench in intended TEXTOR disruptions. Runaway electron (RE) suppression has been experimentally found at magnetic turbulence larger than a certain threshold. Below this threshold, the generated RE current is inversely proportional to the level of magnetic turbulence. The magnetic turbulence originates from the background plasma and the amplitude depends strongly on the toroidal magnetic field and plasma electron density. These results explain the previously found toroidal field threshold for RE generation and have to be considered in predictions for RE generation in ITER.

  8. Assessing the risk of observing multiple generations of Middle East respiratory syndrome (MERS) cases given an imported case.

    PubMed

    Nishiura, H; Miyamatsu, Y; Chowell, G; Saitoh, M

    2015-07-09

    To guide risk assessment, expected numbers of cases and generations were estimated, assuming a case importation of Middle East respiratory syndrome (MERS). Our analysis of 36 importation events yielded the risk of observing secondary transmission events at 22.7% (95% confidence interval: 19.3–25.1). The risks of observing generations 2, 3 and 4 were estimated at 10.5%, 6.1% and 3.9%, respectively. Countries at risk should be ready for highly variable outcomes following an importation of MERS.

  9. Transplantation of storm-generated coral fragments to enhance Caribbean coral reefs: A successful method but not a solution

    USGS Publications Warehouse

    Garrison, V.H.; Ward, G.

    2012-01-01

    In response to dramatic losses of reef-building corals and ongoing lack of recovery, a small-scale coral transplant project was initiated in the Caribbean (U.S. Virgin Islands) in 1999 and was followed for 12 years. The primary objectives were to (1) identify a source of coral colonies for transplantation that would not result in damage to reefs, (2) test the feasibility of transplanting storm-generated coral fragments, and (3) develop a simple, inexpensive method for transplanting fragments that could be conducted by the local community. The ultimate goal was to enhance abundance of threatened reef-building species on local reefs. Storm-produced coral fragments of two threatened reef-building species [Acropora palmata and A. cervicornis (Acroporidae)] and another fast-growing species [Porites porites (Poritidae)] were collected from environments hostile to coral fragment survival and transplanted to degraded reefs. Inert nylon cable ties were used to attach transplanted coral fragments to dead coral substrate. Survival of 75 reference colonies and 60 transplants was assessed over 12 years. Only 9% of colonies were alive after 12 years: no A. cervicornis; 3% of A. palmata transplants and 18% of reference colonies; and 13% of P. porites transplants and 7% of reference colonies. Mortality rates for all species were high and were similar for transplant and reference colonies. Physical dislodgement resulted in the loss of 56% of colonies, whereas 35% died in place. Only A. palmata showed a difference between transplant and reference colony survival and that was in the first year only. Location was a factor in survival only for A. palmata reference colonies and after year 10. Even though the tested methods and concepts were proven effective in the field over the 12-year study, they do not present a solution. No coral conservation strategy will be effective until underlying intrinsic and/or extrinsic factors driving high mortality rates are understood and mitigated or

  10. Experimental observation of acoustic emissions generated by a pulsed proton beam from a hospital-based clinical cyclotron

    SciTech Connect

    Jones, Kevin C.; Solberg, Timothy D.; Avery, Stephen; Vander Stappen, François; Janssens, Guillaume; Prieels, Damien; Bawiec, Christopher R.; Lewin, Peter A.; Sehgal, Chandra M.

    2015-12-15

    Purpose: To measure the acoustic signal generated by a pulsed proton spill from a hospital-based clinical cyclotron. Methods: An electronic function generator modulated the IBA C230 isochronous cyclotron to create a pulsed proton beam. The acoustic emissions generated by the proton beam were measured in water using a hydrophone. The acoustic measurements were repeated with increasing proton current and increasing distance between detector and beam. Results: The cyclotron generated proton spills with rise times of 18 μs and a maximum measured instantaneous proton current of 790 nA. Acoustic emissions generated by the proton energy deposition were measured to be on the order of mPa. The origin of the acoustic wave was identified as the proton beam based on the correlation between acoustic emission arrival time and distance between the hydrophone and proton beam. The acoustic frequency spectrum peaked at 10 kHz, and the acoustic pressure amplitude increased monotonically with increasing proton current. Conclusions: The authors report the first observation of acoustic emissions generated by a proton beam from a hospital-based clinical cyclotron. When modulated by an electronic function generator, the cyclotron is capable of creating proton spills with fast rise times (18 μs) and high instantaneous currents (790 nA). Measurements of the proton-generated acoustic emissions in a clinical setting may provide a method for in vivo proton range verification and patient monitoring.

  11. Experimental observation of acoustic emissions generated by a pulsed proton beam from a hospital-based clinical cyclotron.

    PubMed

    Jones, Kevin C; Vander Stappen, François; Bawiec, Christopher R; Janssens, Guillaume; Lewin, Peter A; Prieels, Damien; Solberg, Timothy D; Sehgal, Chandra M; Avery, Stephen

    2015-12-01

    To measure the acoustic signal generated by a pulsed proton spill from a hospital-based clinical cyclotron. An electronic function generator modulated the IBA C230 isochronous cyclotron to create a pulsed proton beam. The acoustic emissions generated by the proton beam were measured in water using a hydrophone. The acoustic measurements were repeated with increasing proton current and increasing distance between detector and beam. The cyclotron generated proton spills with rise times of 18 μs and a maximum measured instantaneous proton current of 790 nA. Acoustic emissions generated by the proton energy deposition were measured to be on the order of mPa. The origin of the acoustic wave was identified as the proton beam based on the correlation between acoustic emission arrival time and distance between the hydrophone and proton beam. The acoustic frequency spectrum peaked at 10 kHz, and the acoustic pressure amplitude increased monotonically with increasing proton current. The authors report the first observation of acoustic emissions generated by a proton beam from a hospital-based clinical cyclotron. When modulated by an electronic function generator, the cyclotron is capable of creating proton spills with fast rise times (18 μs) and high instantaneous currents (790 nA). Measurements of the proton-generated acoustic emissions in a clinical setting may provide a method for in vivo proton range verification and patient monitoring.

  12. Measurements and observations of noise from a 4.2 megawatt (WTS-4) wind turbine generator

    NASA Technical Reports Server (NTRS)

    Shepherd, K. P.; Hubbard, H. H.

    1983-01-01

    Noise measurements and calculations are being made for large wind turbine generators to develop a data base for use in designing and siting such systems for community acceptance. As part of this program, measurements were made on the WTS-4 wind turbine generator during its acceptance runs. This paper presents the results of these exploratory measurements for power output conditions in the range 1.0 to 4.2 MW. Data include noise levels, spectra, radiation patterns, effects of distance, and the associated perception thresholds for use in the further development of acceptance criteria for this type of machine.

  13. What climate changes could be observed by two generations of Poles?

    NASA Astrophysics Data System (ADS)

    Szwed, M.

    2010-09-01

    For many years, numerous scientific papers in different disciplines have been published on different aspects of the global warming. The issue of climate change and its impacts has become certainly a "fashionable" research area. In Poland, for example, the issue was tackled by one of the greatest hydro-climatological research projects, namely: "Extreme meteorological and hydrological events in Poland (the evaluation of forecasting events and their effects on human environment)". However, for several years, and certainly since 2007, when Al Gore, former U.S. vice-president, and the Intergovernmental Panel on Climate Change (IPCC) won the Nobel Peace Prize, this topic has started to be increasingly more frequently raised by the Polish media. The average Polish citizen increasingly more often learns from the press, radio and television about the global warming. There are also those skeptical of the climate change who loudly express their opinions in the media. Can the average Pole not get lost in the thicket of information? Can they refer to their own memory or the memory of their parents or grandparents on issues of climate change? How is the typical summer or winter perceived the previous generations? Is it possible to observe such changes without reference to extreme events? This article is to try to answer the question whether the average Pole could see climate change, most simply understood as changes in the thermal conditions and precipitations. If yes, then what seasons or months see the biggest changes. Which parts of the country witness the biggest changes? The starting point of the analysis are the 58-years time series of real monthly temperature and precipitation in the period of 1951-2008 for 20 stations across Poland. However, they will not be analyzed in more detail. In order to smooth the data sequences and thus to reject the short-term fluctuations, the long-term moving averages in different sequences (individual months, seasons and years) will be

  14. A successive-steady-state approach to integrated surface-subsurface modelling for runoff generation on the field scale

    NASA Astrophysics Data System (ADS)

    Appels, W. M.; Bogaart, P. W.; van der Zee, S. E. A. T. M.

    2012-04-01

    runoff generation. In the saturated zone only horizontal flow occurs. Radial flow towards the ditches is accounted for via a ditch entry resistance. With this model it is possible to efficiently analyse, with adequate accuracy, the relations between the various compartments. In this presentation we describe the model structure, and present applications to both instructive hypothetical cases and real-work field-scale applications. Issues regarding upscaling of towards catchment and regional scales are discussed.

  15. Experimental observation of multistability and dynamic attractors in silicon central pattern generators

    NASA Astrophysics Data System (ADS)

    Zhao, Le; Nogaret, Alain

    2015-11-01

    We report on the multistability of chaotic networks of silicon neurons and demonstrate how spatiotemporal sequences of voltage oscillations are selected with timed current stimuli. A three neuron central pattern generator was built by interconnecting Hodgkin-Huxley neurons with mutually inhibitory links mimicking gap junctions. By systematically varying the timing of current stimuli applied to individual neurons, we generate the phase lag maps of neuronal oscillators and study their dependence on the network connectivity. We identify up to six attractors consisting of triphasic sequences of unevenly spaced pulses propagating clockwise and anticlockwise. While confirming theoretical predictions, our experiments reveal more complex oscillatory patterns shaped by the ratio of the pulse width to the oscillation period. Our work contributes to validating the command neuron hypothesis.

  16. Experimental observation of multistability and dynamic attractors in silicon central pattern generators.

    PubMed

    Zhao, Le; Nogaret, Alain

    2015-01-01

    We report on the multistability of chaotic networks of silicon neurons and demonstrate how spatiotemporal sequences of voltage oscillations are selected with timed current stimuli. A three neuron central pattern generator was built by interconnecting Hodgkin-Huxley neurons with mutually inhibitory links mimicking gap junctions. By systematically varying the timing of current stimuli applied to individual neurons, we generate the phase lag maps of neuronal oscillators and study their dependence on the network connectivity. We identify up to six attractors consisting of triphasic sequences of unevenly spaced pulses propagating clockwise and anticlockwise. While confirming theoretical predictions, our experiments reveal more complex oscillatory patterns shaped by the ratio of the pulse width to the oscillation period. Our work contributes to validating the command neuron hypothesis.

  17. Developing single-molecule TPM experiments for direct observation of successful RecA-mediated strand exchange reaction.

    PubMed

    Fan, Hsiu-Fang; Cox, Michael M; Li, Hung-Wen

    2011-01-01

    RecA recombinases play a central role in homologous recombination. Once assembled on single-stranded (ss) DNA, RecA nucleoprotein filaments mediate the pairing of homologous DNA sequences and strand exchange processes. We have designed two experiments based on tethered particle motion (TPM) to investigate the fates of the invading and the outgoing strands during E. coli RecA-mediated pairing and strand exchange at the single-molecule level in the absence of force. TPM experiments measure the tethered bead Brownian motion indicative of the DNA tether length change resulting from RecA binding and dissociation. Experiments with beads labeled on either the invading strand or the outgoing strand showed that DNA pairing and strand exchange occurs successfully in the presence of either ATP or its non-hydrolyzable analog, ATPγS. The strand exchange rates and efficiencies are similar under both ATP and ATPγS conditions. In addition, the Brownian motion time-courses suggest that the strand exchange process progresses uni-directionally in the 5'-to-3' fashion, using a synapse segment with a wide and continuous size distribution.

  18. Observation

    ERIC Educational Resources Information Center

    Helfrich, Shannon

    2016-01-01

    Helfrich addresses two perspectives from which to think about observation in the classroom: that of the teacher observing her classroom, her group, and its needs, and that of the outside observer coming into the classroom. Offering advice from her own experience, she encourages and defends both. Do not be afraid of the disruption of outside…

  19. Observations

    ERIC Educational Resources Information Center

    Joosten, Albert Max

    2016-01-01

    Joosten begins his article by telling us that love and knowledge together are the foundation for our work with children. This combination is at the heart of our observation. With this as the foundation, he goes on to offer practical advice to aid our practice of observation. He offers a "List of Objects of Observation" to help guide our…

  20. NextGEOSS: The Next Generation Data Hub For Earth Observations

    NASA Astrophysics Data System (ADS)

    Lilja Bye, Bente; De Lathouwer, Bart; Catarino, Nuno; Concalves, Pedro; Trijssenaar, Nicky; Grosso, Nuno; Meyer-Arnek, Julian; Goor, Erwin

    2017-04-01

    The Group on Earth observation embarked on the next 10 year phase with an ambition to streamline and further develop its achievements in building the Global Earth Observing System of Systems (GEOSS). The NextGEOSS project evolves the European vision of GEOSS data exploitation for innovation and business, relying on the three main pillars of engaging communities, delivering technological developments and advocating the use of GEOSS, in order to support the creation and deployment of Earth observation based innovative research activities and commercial services. In this presentation we will present the NextGEOSS concept, a concept that revolves around providing the data and resources to the users communities, together with Cloud resources, seamlessly connected to provide an integrated ecosystem for supporting applications. A central component of NextGEOSS is the strong emphasis put on engaging the communities of providers and users, and bridging the space in between.

  1. First Observational Support for Overlapping Reionized Bubbles Generated by a Galaxy Overdensity

    NASA Astrophysics Data System (ADS)

    Castellano, M.; Dayal, P.; Pentericci, L.; Fontana, A.; Hutter, A.; Brammer, G.; Merlin, E.; Grazian, A.; Pilo, S.; Amorin, R.; Cristiani, S.; Dickinson, M.; Ferrara, A.; Gallerani, S.; Giallongo, E.; Giavalisco, M.; Guaita, L.; Koekemoer, A.; Maiolino, R.; Paris, D.; Santini, P.; Vallini, L.; Vanzella, E.; Wagg, J.

    2016-02-01

    We present an analysis of deep Hubble Space Telescope (HST) multi-band imaging of the BDF field specifically designed to identify faint companions around two of the few Lyα emitting galaxies spectroscopically confirmed at z ˜ 7. Although separated by only 4.4 proper Mpc these galaxies cannot generate H ii regions large enough to explain the visibility of their Lyα lines, thus requiring a population of fainter ionizing sources in their vicinity. We use deep HST and VLT-Hawk-I data to select z ˜ 7 Lyman break galaxies around the emitters. We select six new robust z ˜ 7 LBGs at Y ˜ 26.5-27.5 whose average spectral energy distribution is consistent with the objects being at the redshift of the close-by Lyα emitters. The resulting number density of z ˜ 7 LBGs in the BDF field is a factor of approximately three to four higher than expected in random pointings of the same size. We compare these findings with cosmological hydrodynamic plus radiative transfer simulations of a universe with a half neutral IGM: we find that indeed Lyα emitter pairs are only found in completely ionized regions characterized by significant LBG overdensities. Our findings match the theoretical prediction that the first ionization fronts are generated within significant galaxy overdensities and support a scenario where faint, “normal” star-forming galaxies are responsible for reionization.

  2. Observing and predicting the spatial-temporal pattern of runoff generation processes from the watershed to the regional scale

    NASA Astrophysics Data System (ADS)

    Weiler, M.

    2012-12-01

    Runoff generation processes are the key to understand and predict watershed dynamics and behaviour under current as well as under changing conditions. A variety of approaches have been developed to observe these processes at the plot scale (e.g. infiltration and sprinkling experiments), the hillslope scale (soil moisture and piezometer networks and trenching) and the watershed scale (hydrograph separation with stable isotopes and natural tracers). However, predicting the four major runoff generation mechanisms (infiltration excess, saturation excess, subsurface flow and deep percolation) without detailed observation in ungauged watershed is still a challenge, but a prerequisite to track water flow pathways and to make adequate prediction for hydrological extremes. Methods have been developed to map dominant runoff generation processes in the field and with digital maps, however, these methods are often static and do not consider the temporal dynamics of runoff generation processes frequently observed with the various experimental approaches. The recently developed parsimonious rainfall-runoff model DROGen can bridge the gap between across spatial scales in ungauged watersheds since parameters are not calibrated. The model incorporates high-resolution GIS data (1m resolution DEM, land-use, impervious surfaces), hydro-geological and pedological data as well as information about the effect of macropores and preferential flow pathways on runoff generation processes with a comprehensive knowledge base from various field observations and experiments. The model was applied to over 6500 meso-scale watershed in the State of Baden-Württemberg in Germany and 15 gauged watersheds were selected for detailed model evaluation. The evaluation was done with field-mapping of runoff generation processes for direct comparison with the simulated pattern of runoff processes for different types of precipitation (high intensity and short duration / low intensity and long duration) and

  3. Challenges to Lake Superior's Condition, Assessment, and Management: A Few Observations Across a Generation of Change

    EPA Science Inventory

    Selected comparisons of water quality and biological properties in lakewide samplings of 1970s and 2005/2006 provide a simple illustration of significant changes within Lake Superior in the last three decades. Observations of warmed surface layers, increased nitrate and increase...

  4. The Personalized Spouse Observation Checklist: A Computer-Generated Assessment of Marital Interaction.

    ERIC Educational Resources Information Center

    Atkinson, Brent J.; McKenzie, Paul N.

    1984-01-01

    Describes the development of a personalized version of the Spouse Observation Checklist (SOC), using computer word processing functions to delete neutral and irrelevant items. Comparison of the original and revised checklists with 22 married individuals indicated no significant differences between dependent variables on the two versions. (JAC)

  5. Challenges to Lake Superior's Condition, Assessment, and Management: A Few Observations Across a Generation of Change

    EPA Science Inventory

    Selected comparisons of water quality and biological properties in lakewide samplings of 1970s and 2005/2006 provide a simple illustration of significant changes within Lake Superior in the last three decades. Observations of warmed surface layers, increased nitrate and increase...

  6. Navigating the transition to college: First-generation undergraduates negotiate identities and search for success in STEM and non-STEM fields

    NASA Astrophysics Data System (ADS)

    Mussey, Season Shelly

    2009-12-01

    Historically, racial and ethnic minority students from low income backgrounds have faced unequal access to colleges and universities. Recently, both K-12 and higher education institutions, specifically the University of California, in response to Proposition 209, have made efforts to increase access and opportunities for all students. Similarly, female minority students are underrepresented in selected science, technology, engineering and math (STEM) majors and careers. Using a qualitative research design, this study investigates how first generation, low income, underrepresented minority students who graduated from an innovative college preparatory high school enact coping strategies that they were explicitly taught to achieve success within the context of university science and math courses. The presence of a unique, college-prep high school on the campus of UC San Diego, which accepts exclusively low-income students through a randomized lottery system, creates an unusual opportunity to study the transition from high school to college for this population, a cohort of underrepresented students who were taught similar academic coping strategies for success in college. This study aims to understand how students develop their college-going, academic identities within the context of their colleges and universities. Furthermore, this study intends to understand the phenomenon of "transition to college" as a lived experience of first-generation, low income, minority students, who all share a similar college preparatory, high school background. The main research questions are: (1) How do underrepresented students experience the transition from a college preparatory high school to college? (2) How are students developing their college-going, academic identities in the context of their educational institutions? and (3) What factors support or constrain student participation and success in college science courses? Twenty-eight students participated in this study. Based on

  7. An observational study of the success and complications of 2546 external cephalic versions in low-risk pregnant women performed by trained midwives.

    PubMed

    Beuckens, A; Rijnders, M; Verburgt-Doeleman, G H M; Rijninks-van Driel, G C; Thorpe, J; Hutton, E K

    2016-02-01

    To evaluate the success of an external cephalic version (ECV) training programme, and to determine the rates of successful ECV, complications, and caesarean birth in a low-risk population. Prospective observational study. Primary health care and hospital settings throughout the Netherlands (January 2008-September 2011). Low-risk women with a singleton fetus in breech presentation, without contraindications to ECV, were offered ECV at approximately 36 weeks of gestation. Data were collected for all ECVs performed by midwives, and were entered into a national online database. Successful ECV was defined as the fetus having a cephalic presentation immediately following the procedure and at birth. Complications were observed at ≤ 30 minutes and between 30 minutes and 48 hours after the ECV procedure. All serious pregnancy outcomes that occurred after the ECV procedure until birth were reported. A total of 47% had a successful ECv and a cephalic at the time of birth: 34% of nulliparous and 66% of multiparous women. After ECV, 57% of women gave birth vaginally: 45% of nulliparous women and 76% of multiparous women. Within 30 minutes after ECV, and between 30 minutes and 48 hours after ECV, the proportion of women experiencing a complication or serious pregnancy outcome was 0.9% and 1.8%, respectively. Serious pregnancy outcome at any time following ECV until birth was experienced by 58 (2.5%) of the women. The success rate of ECVs performed by trained midwives in primary health care or hospital settings is comparable with that of other providers, and the procedure is safe for low-risk women. © 2015 Royal College of Obstetricians and Gynaecologists.

  8. Observation of Wakefield Generation in Left-Handed Band of Metamaterial-Loaded Waveguide

    SciTech Connect

    Antipov, S.; Spentzouris, L.; Liu, W.; Gai, W.; Power, J. G.

    2009-01-22

    We report on a design of a TM-mode based metamaterial-loaded waveguide. Network analyzer measurements demonstrated a left-handed propagation region for the TM11 mode at around 10 GHz. A beamline experiment was performed with the metamaterial-loaded waveguide. In this experiment, a 6 MeV electron beam passes through the waveguide and generates a wakefield, via the Cherenkov radiation mechanism. We detected a signal in the left-handed frequency band at 10 GHz. This is an indirect demonstration of reverse Cherenkov radiation as discussed in several papers. Cherenkov radiation in artificially constructed materials (metamaterials, MTM) can provide unusual, engineered features that can be advantageous for particle detector design.

  9. 4th generation of the 1st level surface detector trigger in the Pierre Auger Observator

    NASA Astrophysics Data System (ADS)

    Szadkowski, Z.

    The proposal of a new 4th generation of the Front-End with the advanced 1st level triggers for the Infill Array of the Pierre Auger Observatory and for the Auger North is described. Newest FPGA chips offer much higher capacity of logic registers and memories, as well as DSP blocks. The calibration channel, previously supported by an external dual-port RAM, has been fully implemented into FPGA chip, through a large internal memory. In turn DSP blocks allowed on implementation of much more sophisticated spectral trigger algorithms. A single chip simplified board design, newer architecture of FPGA reduced resouces utilization and power consumption. Higher sampling in the new Front- End in comparison with previous 40 MHz designs as well as free resources for new detection algotithms can be a good platform for CR radio detection technique at Auger enhancing a duty cycle for the detection of UHECR’s.

  10. Observations of wind-generated shoreface currents off Duck, North Carolina

    USGS Publications Warehouse

    Xu, J. P.; Wright, L.D.

    1998-01-01

    Wind, wave and currents measurements at 9 and 14 meter water depths on the shoreface off U.S. Army Corps of Engineers Field Research Facility at Duck, North Carolina are presented. Coastal setup accompanied by southerly-setting alongshore currents and seaward cross-shore currents is developed during Northeasterly storms. Coastal setdown, with reversal currents, is generated by Southerly or southwesterly strong winds. However, while the current speed during Northeasterly storms is strongly correlated with the wind stress, this relationship does not hold during Southwesterly storms. This is attributable to the fact that downwelling-favorable Northeasterlies enhance the coastal jet and act to reinforce the coastal plume that often issues from the Chesapeake Bay.

  11. Observation of Self-Generated Flows in Tokamak Plasmas with Lower-Hybrid-Driven Current

    SciTech Connect

    Ince-Cushman, A.; Rice, J. E.; Reinke, M.; Greenwald, M.; Wallace, G.; Parker, R.; Fiore, C.; Hughes, J. W.; Bonoli, P.; Shiraiwa, S.; Hubbard, A.; Wolfe, S.; Hutchinson, I. H.; Marmar, E.; Bitter, M.; Wilson, J.; Hill, K.

    2009-01-23

    In Alcator C-Mod discharges lower hybrid waves have been shown to induce a countercurrent change in toroidal rotation of up to 60 km/s in the central region of the plasma (r/a{approx}<0.4). This modification of the toroidal rotation profile develops on a time scale comparable to the current redistribution time ({approx}100 ms) but longer than the energy and momentum confinement times ({approx}20 ms). A comparison of the co- and countercurrent injected waves indicates that current drive (as opposed to heating) is responsible for the rotation profile modifications. Furthermore, the changes in central rotation velocity induced by lower hybrid current drive (LHCD) are well correlated with changes in normalized internal inductance. The application of LHCD has been shown to generate sheared rotation profiles and a negative increment in the radial electric field profile consistent with a fast electron pinch.

  12. FIRST OBSERVATIONAL SUPPORT FOR OVERLAPPING REIONIZED BUBBLES GENERATED BY A GALAXY OVERDENSITY

    SciTech Connect

    Castellano, M.; Pentericci, L.; Fontana, A.; Merlin, E.; Grazian, A.; Pilo, S.; Amorin, R.; Giallongo, E.; Guaita, L.; Paris, D.; Dayal, P.; Hutter, A.; Brammer, G.; Koekemoer, A.; Cristiani, S.; Dickinson, M.; Ferrara, A.; Gallerani, S.; Giavalisco, M.; Maiolino, R.; and others

    2016-02-10

    We present an analysis of deep Hubble Space Telescope (HST) multi-band imaging of the BDF field specifically designed to identify faint companions around two of the few Lyα emitting galaxies spectroscopically confirmed at z ∼ 7. Although separated by only 4.4 proper Mpc these galaxies cannot generate H ii regions large enough to explain the visibility of their Lyα lines, thus requiring a population of fainter ionizing sources in their vicinity. We use deep HST and VLT-Hawk-I data to select z ∼ 7 Lyman break galaxies around the emitters. We select six new robust z ∼ 7 LBGs at Y ∼ 26.5–27.5 whose average spectral energy distribution is consistent with the objects being at the redshift of the close-by Lyα emitters. The resulting number density of z ∼ 7 LBGs in the BDF field is a factor of approximately three to four higher than expected in random pointings of the same size. We compare these findings with cosmological hydrodynamic plus radiative transfer simulations of a universe with a half neutral IGM: we find that indeed Lyα emitter pairs are only found in completely ionized regions characterized by significant LBG overdensities. Our findings match the theoretical prediction that the first ionization fronts are generated within significant galaxy overdensities and support a scenario where faint, “normal” star-forming galaxies are responsible for reionization.

  13. Multistation observations of the azimuth, polarization, and frequency dependence of ELF/VLF waves generated by electrojet modulation

    NASA Astrophysics Data System (ADS)

    Maxworth, A. S.; Gołkowski, M.; Cohen, M. B.; Moore, R. C.; Chorsi, H. T.; Gedney, S. D.; Jacobs, R.

    2015-10-01

    Modulated ionospheric heating experiments are performed with the High Frequency Active Auroral Research Program facility in Gakona, Alaska, for the purpose of generating extremely low frequency (ELF) and very low frequency (VLF) waves. Observations are made at three different azimuths from the heating facility and at distances from 37 km to 99 km. The polarization of the observed waves is analyzed in addition to amplitude as a function of modulation frequency and azimuth. Amplitude and eccentricity are observed to vary with both azimuth and distance from the heating facility. It is found that waves radiated at azimuths northwest of the facility are generated by a combination of modulated Hall and Pedersen currents, while waves observed at other azimuths are dominated by modulated Hall currents. We find no evidence for vertical currents contributing to ground observations of ELF/VLF waves. Observed amplitude peaks near multiples of 2 kHz are shown to result from vertical resonances in the Earth-ionosphere waveguide, and variations of the frequency of these resonances can be used to determine the D region ionosphere electron density profile in the vicinity of the HF heater.

  14. Convectively Generated Meso-Scale Gravity Waves in ER-2 Observations During CRYSTAL-FACE

    NASA Astrophysics Data System (ADS)

    Wang, L.; Alexander, M. J.

    2004-12-01

    The MMS and MTP data from ER-2 observations during the CRYSTAL-FACE campaign are analyzed to retrieve meso-scale gravity wave information at the aircraft flight level. For a given flight segment, the S-transform is used to locate small-scale (10-25 km) gravity wave events. The Stokes method and the MTP method are then used to determine the horizontal propagation directions, and the vertical scales of the wave events, respectively. Other wave parameters, such as horizontal scales, group velocities, can also be derived. From the estimated propagation directions, group velocities, and the ground-based radar reflectivity observations, some wave events are traced back to convectively active regions, suggesting convection as the source of the waves.

  15. SEQ-POINTER: Next generation, planetary spacecraft remote sensing science observation design tool

    NASA Technical Reports Server (NTRS)

    Boyer, Jeffrey S.

    1994-01-01

    Since Mariner, NASA-JPL planetary missions have been supported by ground software to plan and design remote sensing science observations. The software used by the science and sequence designers to plan and design observations has evolved with mission and technological advances. The original program, PEGASIS (Mariners 4, 6, and 7), was re-engineered as POGASIS (Mariner 9, Viking, and Mariner 10), and again later as POINTER (Voyager and Galileo). Each of these programs were developed under technological, political, and fiscal constraints which limited their adaptability to other missions and spacecraft designs. Implementation of a multi-mission tool, SEQ POINTER, under the auspices of the JPL Multimission Operations Systems Office (MOSO) is in progress. This version has been designed to address the limitations experienced on previous versions as they were being adapted to a new mission and spacecraft. The tool has been modularly designed with subroutine interface structures to support interchangeable celestial body and spacecraft definition models. The computational and graphics modules have also been designed to interface with data collected from previous spacecraft, or on-going observations, which describe the surface of each target body. These enhancements make SEQ POINTER a candidate for low-cost mission usage, when a remote sensing science observation design capability is required. The current and planned capabilities of the tool will be discussed. The presentation will also include a 5-10 minute video presentation demonstrating the capabilities of a proto-Cassini Project version that was adapted to test the tool. The work described in this abstract was performed by the Jet Propulsion Laboratory, California Institute of Technology, under contract to the National Aeronautics and Space Administration.

  16. Improving Aerosol and Visibility Forecasting Capabilities Using Current and Future Generations of Satellite Observations

    DTIC Science & Technology

    2013-09-30

    observations alone. With the use of MODIS cloud products, which have additional channels that are sensitive to thin cirrus clouds , we have developed a cloud ...occurring over the high latitude southern hemispheric oceans. Globally averaged, our study shows that thin cirrus cloud contamination introduces a...includes the careful examination of uncertainties in satellite aerosol products in relation to cloud contamination, aerosol microphysical bias, and

  17. Improving Aerosol and Visibility Forecasting Capabilities Using Current and Future Generations of Satellite Observations

    DTIC Science & Technology

    2015-08-27

    using ground observations from the NASA Aerosol Robotic Network (AERGNET) and the Micropulse Lidar Network (MPLNET). APPROACH To achieve the...as well as column-integrated x from one High Spectral Resolution Lidar (HSRL) site at Huntsville, AL during the NASA Studies of Emissions and...grant. The CALIOP aerosol trend study is also supported by a NASA grant (NNX14AJ13G). REFERENCES Alfaro-Contreras, R., Zhang, J., Campbell, J. R., and

  18. Dendritic cells (DCs) can be successfully generated from leukemic blasts in individual patients with AML or MDS: an evaluation of different methods.

    PubMed

    Kremser, Andreas; Dressig, Julia; Grabrucker, Christine; Liepert, Anja; Kroell, Tanja; Scholl, Nina; Schmid, Christoph; Tischer, Johanna; Kufner, Stefanie; Salih, Helmut; Kolb, Hans Jochem; Schmetzer, Helga

    2010-01-01

    Myeloid-leukemic cells (AML, MDS, CML) can be differentiated to leukemia-derived dendritic cell [DC (DCleu)] potentially presenting the whole leukemic antigen repertoire without knowledge of distinct leukemia antigens and are regarded as promising candidates for a vaccination strategy. We studied the capability of 6 serum-free DC culture methods, chosen according to different mechanisms, to induce DC differentiation in 137 cases of AML and 52 cases of MDS. DC-stimulating substances were cytokines ("standard-medium", "MCM-Mimic", "cytokine-method"), bacterial lysates ("Picibanil"), double-stranded RNA ["Poly (I:C)"] or a cytokine bypass method ("Ca-ionophore"). The quality/quantity of DC generated was estimated by flow cytometry studying (co) expressions of "DC"antigens, costimulatory, maturation, and blast-antigens. Comparing these methods on average 15% to 32% DC, depending on methods used, could be obtained from blast-containing mononuclear cells (MNC) in AML/MDS cases with a DC viability of more than 60%. In all, 39% to 64% of these DC were mature; 31% to 52% of leukemic blasts could be converted to DCleu and DCleu-proportions in the suspension were 2% to 70% (13%). Average results of all culture methods tested were comparable, however not every given case of AML could be differentiated to DC with 1 selected method. However performing a pre-analysis with 3 DC-generating methods (MCM-Mimic, Picibanil, Ca-ionophore) we could generate DC in any given case. Functional analyses provided proof, that DC primed T cells to antileukemia-directed cytotoxic cells, although an anti-leukemic reaction was not achieved in every case. In summary our data show that a successful, quantitative DC/DCleu generation is possible with the best of 3 previously tested methods in any given case. Reasons for different functional behaviors of DC-primed T cells must be evaluated to design a practicable DC-based vaccination strategy.

  19. Upstream-generated Pc3 ULF wave signatures observed near the Earth's cusp

    NASA Astrophysics Data System (ADS)

    Yeoman, T. K.; Wright, D. M.; Engebretson, M. J.; Lessard, M. R.; Pilipenko, V. A.; Kim, H.

    2012-03-01

    Pc3 pulsations (frequency ˜20-100 mHz) which originate in the ion foreshock upstream of the Earth's bow shock due to the interaction between reflected ions and the solar wind are frequently observed in ground-based pulsation magnetometer data. Previous studies have noted increased Pc3 wave power in the vicinity of the dayside cusp and inferred that the upstream waves gained entry via the cusp, although more recent studies have revealed a more complex picture. Here, we examine Pc3 wave power near local noon observed by search coil magnetometers at three closely-spaced stations on Svalbard, during times when an extended interval of HF radar backscatter indicative of the cusp is detected by the Hankasalmi SuperDARN radar. The location of the equatorward edge of the HF radar cusp may then be directly compared with the Pc3 wave power measured at three latitudes as the cusp migrates across the stations on a statistical basis. These observations are more consistent with wave entry to the magnetosphere along closed field lines equatorward of the cusp via the ionospheric transistor mechanism of Engebretson et al. (1991a), or weakly coupled fast and Alfvén wave modes, which then map to the low-latitude boundary layer or outer magnetosphere, rather than with wave entry into the magnetosphere via the cusp proper or exterior cusp.

  20. Observation of far-field Mach waves generated by the 2001 Kokoxili supershear earthquake

    NASA Astrophysics Data System (ADS)

    Vallée, M.; Dunham, Eric M.

    2012-03-01

    Regional surface wave observations offer a powerful tool for determining source properties of large earthquakes, especially rupture velocity. Supershear ruptures, being faster than surface wave phase velocities, create far-field surface wave Mach cones along which waves from all sections of the fault arrive simultaneously and, over a sufficiently narrow frequency band, in phase. We present the first observation of far-field Mach waves from the major Kokoxili earthquake (Tibet, 2001/11/14, Mw 7.9) and confirm that ground motion amplitudes are indeed enhanced on the Mach cone. Theory predicts that on the Mach cone, bandpassed surface wave seismograms from a large supershear rupture will be identical to those from much smaller events with similar focal mechanisms, with an amplitude ratio equal to the ratio of the seismic moments of the two events. Cross-correlation of 15-25 s Love waves from the Kokoxili event with those from a much smaller (Mw 5) foreshock indicates a high degree of similarity (correlation coefficients ranging from 0.8 to 0.95) in waveforms recorded at stations near the far-field Mach cone. This similarity vanishes away from the Mach cone. These observations provide further evidence for supershear propagation of the Kokoxili rupture, and demonstrate how this simple waveform correlation procedure can be used to identify supershear ruptures.

  1. Dynamic Characteristics of X-pinch Experiments Conducted in a Small Capacitive Generator:Refractive Optical Observations.

    NASA Astrophysics Data System (ADS)

    Sepúlveda, Adolfo; Pavez, Cristian; Pedreros, José; Avaria, Gonzalo; San Martín, Patricio; Soto, Leopoldo

    2016-05-01

    Among the dense plasmas configurations of interest for applications as a portable intense source of X-rays, the X-pinches are the most attractive by their brightness, source size, short duration and space localization, being particularly reproducible when they are conducted with fast pulsed power generators. In recent time, several characteristics of the dynamics and emission have been reproduced in compact generators (typically capacitive generators) of low current rise-rate (less than 0.5 kA/ns). In this work, a preliminary characterization of the dynamic of X-pinch plasma conducted in a small capacitive generator is reported. In order to obtain the plasma dynamics and quantitative information of the plasma density, the dark field Schlieren technique and interferometry were implemented. The experiments were carried out on the multipurpose generator (1.2 μF, 345 J, 47.5 nH, T/4=375 ns and Z = 0.2 Ω in short circuit) capable to produce currents up to 122 kA with 500 ns quarter period, when a charging voltage of 24 kV and metallic X-pinches are used as load. The electrical behavior of the discharge and the X-ray emission are monitored with a Rogowski coil and filtered PIN diodes respectively. For the refractive optical diagnostics a 532 nm frequency- doubled Nd-YAG laser was used. As from a single Schlieren record per shot, a sequence with the time evolution of the plasma is constructed. From the images, a similar dynamic of X- pinches conducted in fast generators of high current is observed, where structures such as coronal plasma, plasma flares and plasma jets are identified. The plasma dynamics observed from a VUV gated pinhole image system is compared with registered dynamic with refractive optical techniques.

  2. Pyroclastic Flow Generated Tsunami Waves Detected by CALIPSO Borehole Strainmeters at Soufriere Hills, Montserrat During Massive Dome Collapse: Numerical Simulations and Observations

    NASA Astrophysics Data System (ADS)

    van Boskirk, E. J.; Voight, B.; Watts, P.; Widiwijayanti, C.; Mattioli, G. S.; Elsworth, D.; Hidayat, D.; Linde, A.; Malin, P.; Neuberg, J.; Sacks, S.; Shalev, E.; Sparks, R. J.; Young, S. R.

    2004-12-01

    The July 12-13, 2003 eruption (dome collapse plus explosions) of Soufriere Hills Volcano in Montserrat, WI, is the largest historical lava dome collapse with ˜120 million cubic meters of the dome lost. Pyroclastic flows entered the sea at 18:00 AST 12 July at the Tar River Valley (TRV) and continued until the early hours of 13 July. Low-amplitude tsunamis were reported at Antigua and Guadaloupe soon after the dome collapse. At the time of eruption, four CALIPSO borehole-monitoring stations were in the process of being installed, and three very-broad-band Sacks-Evertson dilatometers were operational and recorded the event at 50 sps. The strongest strain signals were recorded at the Trants site, 5 km north of the TRV entry zone, suggesting tsunami waves >1 m high. Debris strandlines closer to TRV recorded runup heights as much as 8 m. We test the hypothesis that the strain signal is related to tsunami waves generated by successive pyroclastic flows induced during the dome collapse. Tsunami simulation models have been generated using GEOWAVE, which uses simple physics to recreate waves generated by idealized pyroclastic flows entering the sea at TRV. Each simulation run contains surface wave amplitude gauges located in key positions to the three borehole sites. These simulated wave amplitudes and periods are compared quantitatively with the data recorded by the dilatometers and with field observations of wave runup, to elucidate the dynamics of pyroclastic flow tsunami genesis and its propagation in shallow ocean water.

  3. Observation

    ERIC Educational Resources Information Center

    Patell, Hilla

    2016-01-01

    In order to achieve the goal of observation, preparation of the adult, the observer, is necessary. This preparation, says Hilla Patell, requires us to "have an appreciation of the significance of the child's spontaneous activities and a more thorough understanding of the child's needs." She discusses the growth of both the desire to…

  4. Observation

    ERIC Educational Resources Information Center

    Kripalani, Lakshmi A.

    2016-01-01

    The adult who is inexperienced in the art of observation may, even with the best intentions, react to a child's behavior in a way that hinders instead of helping the child's development. Kripalani outlines the need for training and practice in observation in order to "understand the needs of the children and...to understand how to remove…

  5. Observation of tendon repair in animal model using second-harmonic-generation microscopy

    NASA Astrophysics Data System (ADS)

    Hase, Eiji; Minamikawa, Takeo; Sato, Katsuya; Takahashi, Mitsuhiko; Yasui, Takashi

    2016-03-01

    Tendon rupture is a trauma difficult to recover the condition before injury. In previous researches, tensile test and staining method have been widely used to elucidate the mechanism of the repair process from the viewpoints of the mechanical property and the histological findings. However, since both methods are destructive and invasive, it is difficult to obtain both of them for the same sample. If both the mechanical property and the histological findings can be obtained from the same sample, one may obtain new findings regarding mechanisms of tendon repairing process. In this paper, we used second-harmonic-generation (SHG) microscopy, showing high selectivity and good image contrast to collagen molecules as well as high spatial resolution, optical three-dimensional sectioning, deep penetration, and without additional staining. Since SHG light intensity sensitively reflects the structural maturity of collagen molecule and its aggregates, it will be a good indicator for the repairing degree of the ruptured tendon. From comparison of SHG images between the 4-weeks-repaired tendon and the sound tendon in the animal model, we confirmed that SHG light intensity of the repaired tendon was significantly lower than that of the sound tendon, indicating that the collagen structure in the repaired tendon is still immature. Furthermore, we performed both SHG imaging and the tensile test for the same sample, and confirmed a correlation between them. This result shows a potential of SHG light for an indicator of the histological and mechanical recovery of the ruptured tendon.

  6. Experimental observations of transport of picosecond laser generated electrons in a nail-like target

    SciTech Connect

    Pasley, J.; Wei, M.; Shipton, E.; Chen, S.; Ma, T.; Beg, F. N.; Alexander, N.; Stephens, R.; MacPhee, A. G.; Hey, D.; Le Pape, S.; Patel, P.; Mackinnon, A.; Key, M.; Offermann, D.; Link, A.; Chowdhury, E.; Van-Woerkom, L.; Freeman, R. R.

    2007-12-15

    The transport of relativistic electrons, generated by the interaction of a high intensity (2x10{sup 20} W/cm{sup 2}) laser, has been studied in a nail-like target comprised of a 20 {mu}m diameter solid copper wire, coated with {approx}2 {mu}m of titanium, with an 80 {mu}m diameter hemispherical termination. A {approx}500 fs, {approx}200 J pulse of 1.053 {mu}m laser light produced by the Titan Laser at Lawrence Livermore National Laboratory was focused to a {approx}20 {mu}m diameter spot centered on the flat face of the hemisphere. K{sub {alpha}} fluorescence from the Cu and Ti regions was imaged together with extreme ultraviolet (XUV) emission at 68 and 256 eV. Results showed a quasiexponential decline in K{sub {alpha}} emission along the wire over a distance of a few hundred microns from the laser focus, consistent with bulk Ohmic inhibition of the relativistic electron transport. Weaker K{sub {alpha}} and XUV emission on a longer scale length showed limb brightening suggesting a transition to enhanced transport at the surface of the wire.

  7. Observations of E region irregularities generated at auroral latitudes by a high-power radio wave

    NASA Technical Reports Server (NTRS)

    Djuth, F. T.; Jost, R. J.; Noble, S. T.; Gordon, W. E.; Stubbe, P.

    1985-01-01

    The initial results of a series of observations made with the high-power HF heating facility near Tromso, Norway are reported. During these experiments, attention was focused on the production of artificial geomagnetic field-aligned irregularities (AFAIs) in the auroral E region by HF waves. A mobile 46.9-MHz radar was used to diagnose the formation of AFAIs having spatial scales of 3.2 across geomagnetic field lines. The dynamic characteristics of the AFAIs are discussed within the context of current theoretical work dealing with the natural production of AFAIs in the ionosphere.

  8. Observations of E region irregularities generated at auroral latitudes by a high-power radio wave

    NASA Technical Reports Server (NTRS)

    Djuth, F. T.; Jost, R. J.; Noble, S. T.; Gordon, W. E.; Stubbe, P.

    1985-01-01

    The initial results of a series of observations made with the high-power HF heating facility near Tromso, Norway are reported. During these experiments, attention was focused on the production of artificial geomagnetic field-aligned irregularities (AFAIs) in the auroral E region by HF waves. A mobile 46.9-MHz radar was used to diagnose the formation of AFAIs having spatial scales of 3.2 across geomagnetic field lines. The dynamic characteristics of the AFAIs are discussed within the context of current theoretical work dealing with the natural production of AFAIs in the ionosphere.

  9. Observation of quantum interference between a single-photon state and a thermal state generated in optical fibers.

    PubMed

    Li, Xiaoying; Yang, Lei; Cui, Liang; Ou, Zhe Yu; Yu, Daoyin

    2008-08-18

    We experimentally demonstrate a Hong-Ou-Mandel type of two-photon interference effect with a heralded single-photon state and a thermal state. The light sources in the 1550 nm telecom band are generated from two independent dispersion-shifted fibers via four-wave mixing process. The observed visibility is (82+/- 11)%. This type of interference between independent sources is crucial in quantum information process with independent qubits.

  10. Observation of a spark channel generated in water with shock wave assistance in plate-to-plate electrode configuration

    SciTech Connect

    Stelmashuk, V.

    2014-01-15

    When a high voltage pulse with an amplitude of 30 kV is applied to a pair of disk electrodes at a time when a shock wave is passing between them, an electrical spark is generated. The dynamic changes in the spark morphology are studied here using a high-speed framing camera. The primary result of this work is the provision of experimental evidence of plasma instability that was observed in the channel of the electric spark.

  11. HEXITEC: A next generation hard X-ray Detector for Solar Observations

    NASA Astrophysics Data System (ADS)

    Panessa, M.; Christe, S.; Shih, A.; Gaskin, J.; Wilson, M. D.; Seller, P.; Baumgartner, W.; Inglis, A. R.

    2015-12-01

    High angular resolution HXR optics require detectors with a large number of fine pixels in order to adequately sample the telescope point spread function (PSF) over the entire field of view. Recent developments at the Rutherford Appleton Laboratory (RAL) have resulted in a new hard X-ray (HXR) detector system with the smallest independent pixels currently available, 250 microns. This matches perfectly with the best angular resolution currently achievable by HXR focusing optics which is about 5 arcsec (FWHM). For a SMEX mission with a 15 meter focal length each pixel would cover an angular size of about 3 arcsec thereby subsampling the PSF. Dubbed HEXITEC, for High Energy X-Ray Imaging Technology, this Application Specific Integrated Circuit (ASIC), can be bonded to 1- or 2- mm-thick Cadmium Telluride (CdTe) or Cadmium-Zinc-Telluride (CZT) which provide high efficiency in the HXR region, good energy resolution, low background, low power, and low sensitivity to radiation damage. For solar observations, the ability to handle high counting rates is also extremely desirable. This ASIC can read each pixel 10,000 times per second. The NASA Marshall Space Flight Center (MSFC) and the Goddard Space Flight Center (GSFC) has been working with RAL over the past few years to develop these detectors to be used with HXR focusing telescopes. We present recent progress on this development effort and its capabilities as applied to solar observations.

  12. Stochastic generation of flood events to extend observed hydrological series by combining a copula model with hydrometeorological modelling

    NASA Astrophysics Data System (ADS)

    Requena, Ana; Flores, Isabel; Mediero, Luis; Garrote, Luis

    2013-04-01

    A multivariate flood frequency analysis is required for designing some structures like dams. Multivariate copula models are usually used to obtain joint return periods of the flood variables. There exist several families of copulas and a selection procedure is required to find the copula that best fits the observations. Moreover, observed hydrological series are usually short and the fit of the right tail of the copula remains highly uncertain. In this work, a procedure to extend short observed series is proposed by the use of both hydrometeorological modelling and a copula model to generate synthetic hydrographs. The procedure takes synthetic rainstorms events generated by the RainSim software as input. The RIBS rainfall-runoff model is used to simulate the hydrological processes in the basin. The procedure was tested in the Santillana reservoir in Spain, were both RainSim and RIBS models were calibrated prior to this study. A sensitivity analysis was conducted in order to find the minimum synthetic length that makes the copula selection process robust enough. As computational time of hydrometeorological modelling is not negligible, the extended record from modelling results could be re-extended by the fitted copula, reducing the computation time. This final extended hydrological series can be used to improve flood risk assessment studies. Key words: Stochastic generation, copulas, rainfall-runoff modelling Session: HS7.15 - Hydroclimatic stochastics Convener: S. Grimaldi Co-Conveners: A. A. Carsteanu, D. Koutsoyiannis, X. L. Wang and S. M. Papalexiou

  13. Direct observation of adakite melts generated in the lower continental crust, Fiordland, New Zealand.

    NASA Astrophysics Data System (ADS)

    Stevenson, J.; Daczko, N.; Clarke, G.; Pearson, N.; Klepeis, K.

    2003-04-01

    Adakite igneous rocks have a distinctive chemistry that links them to melting of a mafic source at high pressure (P > 1.2 - 1.5 GPa; e.g. Peacock et al. 1994). They have been attributed to melting of subducted oceanic crust (Kay, 1978; Defant and Drummond, 1990) or melting of the crustal roots of thick continental arcs (Atherton and Petford, 1993). We report the first direct evidence for the generation of adakite melts in mafic lower continental crust. The Pembroke Granulite represents the deepest crust (P = 12 - 14 kbar , T = 750 - 800^oC; Daczko et al. 2001) in an exhumed Cretaceous arc in the South Island of New Zealand (Clarke et al., 2000). The Pembroke Granulite has the bulk chemistry, assemblage, and partial melting textures involving peritectic garnet, to be the source region for an adakite melt. The partial melting textures form the source for numerous trondhjemitic vein-filled fractures, which we suggest were the initial conduit for the adakite melt as it migrated away from its source. LA-ICMPS point analyses of minerals in the dioritic gneiss host rock, partial melting textures, and trondhjemitic veins of the Pembroke Granulite are consistent with this interpretation. The originally overlying Separation Point Batholith contains rocks of adakitic composition thought to have been formed through melting in a continental arc (Muir et al., 1995; 1998); the melts formed in the Pembroke Granulite are texturally, compositionally, geochemically, and structurally consistent with being the source of the Separation Point adakites. References: Atherton, M. P. and Petford, N.: Generation of sodium-rich magmas from newly underplated basaltic crust. Nature, 362, 144--146, 1993. Clarke, G. L., Klepeis, K. A. and Daczko, N. R.: Cretaceous high-P granulites at Milford Sound, New Zealand: their metamorphic history and emplacement in a convergent margin setting. J. Metamorphic Geol., 18, 359--374, 2000. Daczko, N. R., Klepeis, K. A. and Clarke, G. L.: Evidence of Early

  14. Observational Studies of Earthquake Preparation and Generation to Mitigate Seismic Risks in Mines

    NASA Astrophysics Data System (ADS)

    Durrheim, R. J.; Ogasawara, H.; Nakatani, M.; Milev, A.; Cichowicz, A.; Kawakata, H.; Yabe, Y.; Murakami, O.; Naoi, M. M.; Moriya, H.; Satoh, T.

    2011-12-01

    We provide a status report on a 5-year project to monitor in-situ fault instability and strong motion in South African gold mines. The project has two main aims: (1) To learn more about earthquake preparation and generation mechanisms by deploying dense arrays of high-sensitivity sensors within rock volumes where mining is likely to induce significant seismic activity. (2) To upgrade the South African national surface seismic network in the mining districts. This knowledge will contribute to efforts to upgrade schemes of seismic hazard assessment and to limit and mitigate the seismic risks in deep mines. As of 31 July 2011, 46 boreholes totalling 1.9 km in length had been drilled at project sites at Ezulwini, Moab-Khotsong and Driefontein gold mines. Several dozen more holes are still to be drilled. Acoustic emission sensors, strain- and tiltmeters, and controlled seismic sources are being installed to monitor the deformation of the rock mass, the accumulation of damage during the preparation phase, and changes in dynamic stress as the rupture front propagates. These data will be integrated with measurements of stope closure, stope strong motion, seismic data recorded by the mine-wide network, and stress modelling. Preliminary results will be reported at AGU meeting. The project is endorsed by the Japan Science and Technology Agency (JST), Japan International Cooperation Agency (JICA) and the South African government. It is funded by the JST-JICA program for Science and Technology Research Partnership for Sustainable development (SATREPS, the Council for Scientific and Industrial Research (CSIR), the Council for Geoscience, the University of the Witwatersrand and the Department of Science and Technology. The contributions of Seismogen CC, OHMS Ltd, AnglogoldAshanti Rock Engineering Applied Research Group, First Uranium, the Gold Fields Seismic Department and the Institute of Mine Seismology are gratefully acknowledged.

  15. Generation of High Resolution Water Vapour Fields from GPS Observations and Integration With ECMWF and MODIS

    NASA Astrophysics Data System (ADS)

    Yu, C.; Li, Z.; Penna, N. T.

    2016-12-01

    Precipitable water vapour (PWV) can be routinely retrieved from ground-based GPS arrays in all-weather conditions and also in real-time. But to provide dense spatial coverage maps, for example for calibrating SAR images, for correcting atmospheric effects in Network RTK GPS positioning and which may be used for numerical weather prediction, the pointwise GPS PWV measurements must be interpolated. Several previous interpolation studies have addressed the importance of the elevation dependency of water vapour, but it is often a challenge to separate elevation-dependent tropospheric delays from turbulent components. We present a tropospheric turbulence iterative decomposition model that decouples the total PWV into (i) a stratified component highly correlated with topography which therefore delineates the vertical troposphere profile, and (ii) a turbulent component resulting from disturbance processes (e.g., severe weather) in the troposphere which trigger uncertain patterns in space and time. We will demonstrate that the iterative decoupled interpolation model generates improved dense tropospheric water vapour fields compared with elevation dependent models, with similar accuracies obtained over both flat and mountainous terrain, as well as for both inland and coastal areas. We will also show that our GPS-based model may be enhanced with ECMWF zenith tropospheric delay and MODIS PWV, producing multi-data sources high temporal-spatial resolution PWV fields. These fields were applied to Sentinel-1 SAR interferograms over the Los Angeles region, for which a maximum noise reduction due to atmosphere artifacts reached 85%. The results reveal that the turbulent troposphere noise, especially those in a SAR image, often occupy more than 50% of the total zenith tropospheric delay and exert systematic, rather than random patterns.

  16. Saturn's Ionospheric Clock(s): A Concept for Generating and Maintaining Saturn's Observed Magnetospheric Periodicities

    NASA Astrophysics Data System (ADS)

    Mitchell, D. G.; Brandt, P. C.; Ukhorskiy, A. Y.

    2010-12-01

    Saturn’s 10.X hour periodicity, observed throughout the magnetosphere, remains a mystery. It has been observed in many regions, modulating many phenomena. During the Cassini mission most observations have shown a period at about 10.8 hours, expressed in Saturn kilometric radiation from the high latitude auroral zone, in magnetic field components (both equatorial and high latitude) from 3 to 12 Rs, in current sheet encounters in the outer magnetosphere and magnetotail, in energetic neutral atom emission from the equatorial magnetosphere, and in plasma and energetic particles throughout the magnetosphere. More recently, various authors have shown at least two dominant periods expressed (in SKR and in magnetic field components), with slightly different values in the southern and northern hemispheres. The cause of this behavior is still not accounted for. Although loosely associated with Saturn’s rotation, the variability in the period precludes a direct connection with Saturn’s interior (e.g., a magnetic anomaly). Other candidates that have been discussed by others are an ionospheric source (conductivity anomaly), a perturbation in the cold plasma circulation pattern, a magnetospheric cam, asymmetric ring current particle pressure, and/or a natural frequency of the magnetosphere (cavity mode or traveling wave front of some sort). In this paper we present a concept that derives its energy from the subcorotating cold, dense plasma (which exhibits a rotation period on the order of 13 to 14 hours throughout L-shells between ~3 and 20), but is triggered by a process linked with the ionosphere. Key components of the model include significant slippage between the ionosphere and the magnetosphere (with the ionosphere rotating at the expressed period in each hemisphere, only slightly more slowly than the planet interior), subcorotating cold dense plasma with a source in the inner magnetosphere, predominantly radial transport of the cold dense plasma in the rotational

  17. Ion hole formation and nonlinear generation of electromagnetic ion cyclotron waves: THEMIS observations

    NASA Astrophysics Data System (ADS)

    Shoji, Masafumi; Miyoshi, Yoshizumi; Katoh, Yuto; Keika, Kunihiro; Angelopoulos, Vassilis; Kasahara, Satoshi; Asamura, Kazushi; Nakamura, Satoko; Omura, Yoshiharu

    2017-09-01

    Electromagnetic plasma waves are thought to be responsible for energy exchange between charged particles in space plasmas. Such an energy exchange process is evidenced by phase space holes identified in the ion distribution function and measurements of the dot product of the plasma wave electric field and the ion velocity. We develop a method to identify ion hole formation, taking into consideration the phase differences between the gyromotion of ions and the electromagnetic ion cyclotron (EMIC) waves. Using this method, we identify ion holes in the distribution function and the resulting nonlinear EMIC wave evolution from Time History of Events and Macroscale Interactions during Substorms (THEMIS) observations. These ion holes are key to wave growth and frequency drift by the ion currents through nonlinear wave-particle interactions, which are identified by a computer simulation in this study.

  18. Generating wind fields that honour point observations and physical conservation laws

    NASA Astrophysics Data System (ADS)

    Schlabing, Dirk; Bárdossy, András

    2015-04-01

    Wind exhibits a strong spatial and temporal variability. In the application of lake modelling, these features are important for simulating water flows and stratification correctly, as mean and variance of wind speed determine the input of momentum into the lake. This makes a mere interpolation of point measurements an unsuitable method for producing model input. Additionally to concrete point measurements, more subtle aspects of wind fields are to be reproduced. It follows from the fact that wind vectors represent moving air that a wind field has to be divergency-free in order to be mass-conservative. Further, a temporal sequence of wind fields has to comply with the Navier-Stokes equation in order to conserve momentum. All these constraints can be met by representing the conditioned wind field as a linear combination of unconditioned, normally distributed random fields that individually possess the same spatial covariance structuref as observed wind fields. The aim of having the same covariance structure in the conditioned wind field is formulated as an optimization problem with respect to the weights used in the linear combination. With the help of Quadratic Programming (QP) and exploiting the convexity of the problem, feasible solutions can easily be found. In this QP problem, observations become linear constraints. Conservation laws can be incorporated by introducing control volumes in a similar fashion as they are used in fluid mechanics. Budgets of flows through these control volumes become integral conditions in the QP problem. The applicability of the approach will be shown using an artificial example and real-world data measured on shore and on a moving boat on Lake Constance.

  19. Influence of finger and mouth action observation on random number generation: an instance of embodied cognition for abstract concepts.

    PubMed

    Grade, Stéphane; Badets, Arnaud; Pesenti, Mauro

    2017-05-01

    Numerical magnitude and specific grasping action processing have been shown to interfere with each other because some aspects of numerical meaning may be grounded in sensorimotor transformation mechanisms linked to finger grip control. However, how specific these interactions are to grasping actions is still unknown. The present study tested the specificity of the number-grip relationship by investigating how the observation of different closing-opening stimuli that might or not refer to prehension-releasing actions was able to influence a random number generation task. Participants had to randomly produce numbers after they observed action stimuli representing either closure or aperture of the fingers, the hand or the mouth, or a colour change used as a control condition. Random number generation was influenced by the prior presentation of finger grip actions, whereby observing a closing finger grip led participants to produce small rather than large numbers, whereas observing an opening finger grip led them to produce large rather than small numbers. Hand actions had reduced or no influence on number production; mouth action influence was restricted to opening, with an overproduction of large numbers. Finally, colour changes did not influence number generation. These results show that some characteristics of observed finger, hand and mouth grip actions automatically prime number magnitude, with the strongest effect for finger grasping. The findings are discussed in terms of the functional and neural mechanisms shared between hand actions and number processing, but also between hand and mouth actions. The present study provides converging evidence that part of number semantics is grounded in sensory-motor mechanisms.

  20. Electromagnetically generated extracorporeal shockwaves for fragmentation of extra-and intrahepatic bile duct stones: indications, success and problems during a 15 months clinical experience.

    PubMed

    Staritz, M; Rambow, A; Grosse, A; Hurst, A; Floth, A; Mildenberger, P; Goebel, M; Junginger, T; Hohenfellner, R; Thelen, M

    1990-02-01

    Electromagnetically generated extracorporeal shock waves (without waterbath) were applied after intravenous premedication with 10-15 mg diazepam and 100 mg tramadol in the treatment of 33 patients (aged 32 to 91 years) with multiple intrahepatic stones (n = 4) or huge common bile duct stones (n = 29, 18-30 mm in diameter), which could not be removed by conventional endoscopy. Stone disintegration was achieved in 70% of common bile duct stones and in all intrahepatic concrements after 800-7500 discharges, which were applied during one (n = 21), two (n = 6) or three sessions (n = 6). Apart from mild fleabite-like petechiae at the side of shock wave transmission no other side effects were observed for a total of 51 procedures. We believe electromagnetically generated shock waves are safe, easy to apply, and relatively effective in the therapy of common bile duct and intrahepatic stones.

  1. Recombinant TSH Stimulated Remnant Ablation Therapy in Thyroid Cancer: The Success Rate Depends on the Definition of Ablation Success—An Observational Study

    PubMed Central

    van der Horst-Schrivers, Anouk N. A.; Sluiter, Wim J.; Muller Kobold, Anneke C.; Wolffenbuttel, Bruce H. R.; Plukker, John T. M.; Bisschop, Peter H.; de Klerk, John M.; Al Younis, Imad; Lips, Paul; Smit, Jan W.; Brouwers, Adrienne H.; Links, Thera P.

    2015-01-01

    Introduction Patients with differentiated thyroid cancer (DTC) are treated with (near)-total thyroidectomy followed by remnant ablation. Optimal radioiodine-131 (131I) uptake is achieved by withholding thyroid hormone (THW), pretreatment with recombinant human Thyrotropin Stimulating Hormone (rhTSH) is an alternative. Six randomized trials have been published comparing THW and rhTSH, however comparison is difficult because an uniform definition of ablation success is lacking. Using a strict definition, we performed an observational study aiming to determine the efficacy of rhTSH as preparation for remnant ablation. Patients and Methods Adult DTC patients with, tumor stage T1b to T3, Nx, N0 and N1, M0 were included in a prospective multicenter observational study with a fully sequential design, using a stopping rule. All patients received remnant ablation with 131I using rhTSH. Ablation success was defined as no visible uptake in the original thyroid bed on a rhTSH stimulated 150 MBq 131I whole body scan (WBS) 9 months after remnant ablation, or no visible uptake in the original thyroid bed on a post therapeutic WBS when a second high dose was necessary. Results After interim analysis of the first 8 patients, the failure rate was estimated to be 69% (90% confidence interval (CI) 20-86%) and the inclusion of new patients had to be stopped. Final analysis resulted in an ablation success in 11 out of 17 patients (65%, 95% CI 38-86%). Conclusion According to this study, the efficacy of rhTSH in the preparation of 131I ablation therapy is inferior, when using a strict definition of ablation success. The current lack of agreement as to the definition of successful remnant ablation, makes comparison between different ablation strategies difficult. Our results point to the need for an international consensus on the definition of ablation success, not only in routine patient’s care but also for scientific reasons. Trial Registration Dutch Trial Registration NTR2395 PMID

  2. Observation-based source terms in the third-generation wave model WAVEWATCH

    NASA Astrophysics Data System (ADS)

    Zieger, Stefan; Babanin, Alexander V.; Erick Rogers, W.; Young, Ian R.

    2015-12-01

    Measurements collected during the AUSWEX field campaign, at Lake George (Australia), resulted in new insights into the processes of wind wave interaction and whitecapping dissipation, and consequently new parameterizations of the input and dissipation source terms. The new nonlinear wind input term developed accounts for dependence of the growth on wave steepness, airflow separation, and for negative growth rate under adverse winds. The new dissipation terms feature the inherent breaking term, a cumulative dissipation term and a term due to production of turbulence by waves, which is particularly relevant for decaying seas and for swell. The latter is consistent with the observed decay rate of ocean swell. This paper describes these source terms implemented in WAVEWATCH III ®and evaluates the performance against existing source terms in academic duration-limited tests, against buoy measurements for windsea-dominated conditions, under conditions of extreme wind forcing (Hurricane Katrina), and against altimeter data in global hindcasts. Results show agreement by means of growth curves as well as integral and spectral parameters in the simulations and hindcast.

  3. Direct observation of generation and propagation of magnetosonic waves following substorm injection

    NASA Astrophysics Data System (ADS)

    Su, Zhenpeng; Wang, Geng; Liu, Nigang; Zheng, Huinan; Wang, Yuming; Wang, Shui

    2017-08-01

    Magnetosonic whistler mode waves play an important role in the radiation belt electron dynamics. Previous theory has suggested that these waves are excited by the ring distributions of hot protons and can propagate radially and azimuthally over a broad spatial range. However, because of the challenging requirements on satellite locations and data processing techniques, this theory was difficult to validate directly. Here we present some experimental tests of the theory on the basis of Van Allen Probes observations of magnetosonic waves following substorm injections. At higher L shells with significant substorm injections, the discrete magnetosonic emission lines started approximately at the proton gyrofrequency harmonics, qualitatively consistent with the prediction of linear proton Bernstein mode instability. In the frequency-time spectrograms, these emission lines exhibited a clear rising tone characteristic with a long duration of 15-25 min, implying the additional contribution of other undiscovered mechanisms. Nearly at the same time, the magnetosonic waves arose at lower L shells without substorm injections. The wave signals at two different locations, separated by ΔL up to 2.0 and by ΔMLT up to 4.2, displayed the consistent frequency-time structures, strongly supporting the hypothesis about the radial and azimuthal propagation of magnetosonic waves.

  4. Earth Observation oriented teaching materials development based on OGC Web services and Bashyt generated reports

    NASA Astrophysics Data System (ADS)

    Stefanut, T.; Gorgan, D.; Giuliani, G.; Cau, P.

    2012-04-01

    Creating e-Learning materials in the Earth Observation domain is a difficult task especially for non-technical specialists who have to deal with distributed repositories, large amounts of information and intensive processing requirements. Furthermore, due to the lack of specialized applications for developing teaching resources, technical knowledge is required also for defining data presentation structures or in the development and customization of user interaction techniques for better teaching results. As a response to these issues during the GiSHEO FP7 project [1] and later in the EnviroGRIDS FP7 [2] project, we have developed the eGLE e-Learning Platform [3], a tool based application that provides dedicated functionalities to the Earth Observation specialists for developing teaching materials. The proposed architecture is built around a client-server design that provides the core functionalities (e.g. user management, tools integration, teaching materials settings, etc.) and has been extended with a distributed component implemented through the tools that are integrated into the platform, as described further. Our approach in dealing with multiple transfer protocol types, heterogeneous data formats or various user interaction techniques involve the development and integration of very specialized elements (tools) that can be customized by the trainers in a visual manner through simple user interfaces. In our concept each tool is dedicated to a specific data type, implementing optimized mechanisms for searching, retrieving, visualizing and interacting with it. At the same time, in each learning resource can be integrated any number of tools, through drag-and-drop interaction, allowing the teacher to retrieve pieces of data of various types (e.g. images, charts, tables, text, videos etc.) from different sources (e.g. OGC web services, charts created through Bashyt application, etc.) through different protocols (ex. WMS, BASHYT API, FTP, HTTP etc.) and to display

  5. Optical observations of meteors generating infrasound: Weak shock theory and validation

    NASA Astrophysics Data System (ADS)

    Silber, Elizabeth A.; Brown, Peter G.; Krzeminski, Zbigniew

    2015-03-01

    We have recorded a data set of 24 cm sized meteoroids detected simultaneously by video and infrasound to critically examine the ReVelle (1974) weak shock meteor infrasound model. We find that the effect of gravity wave perturbations to the wind field and updated absorption coefficients in the linear regime on the initial value of the blast radius (R0), which is the strongly nonlinear zone of shock propagation near the body and corresponds to energy deposition per path length, is relatively small (<10%). Using optical photometry for ground truth for energy deposition, we find that the ReVelle model accurately predicts blast radii from infrasound periods (τ) but systematically underpredicts R0 using pressure amplitude. If the weak shock to linear propagation distortion distance is adjusted as part of the modeling process, we are able to self-consistently fit a single blast radius value for amplitude and period. In this case, the distortion distance is always much less (usually just a few percent) than the value of 10% assumed in the ReVelle model. Our study shows that fragmentation is an important process even for centimeter-sized meteoroids, implying that R0, while a good measure of energy deposition by the meteoroid, is not a reliable means of obtaining the meteoroid mass. We derived an empirical period-blast radius relation of the form R0 = 15.4τ - 0.5 (τ ≤ 0.7 s) and R0 = 29.1τ - 11.6 (τ > 0.7 s) appropriate to centimeter-sized meteoroids. Our observations suggest that meteors having blast radii as small as 1 m are detectable infrasonically at the ground, an order of magnitude smaller than previously considered.

  6. Probing turbulent, magnetized star formation with ALMA observations and next-generation AREPO simulations

    NASA Astrophysics Data System (ADS)

    Hull, Charles L. H.; Mocz, Philip; Burkhart, Blakesley K.; Miquel Girart, Josep; Goodman, Alyssa A.; Cortes, Paulo; Li, Zhi-Yun; Lai, Shih-Ping; Hernquist, Lars; Springel, Volker

    2017-01-01

    The first polarization data from ALMA have been delivered, and are both expanding and confounding our understanding of the role of magnetic fields in low-mass star formation. Here I will show the highest resolution and highest sensitivity polarization images ever made of a Class 0 protostellar source. These new ALMA observations of the source, known as Ser-emb 8, achieve 140 AU resolution, allowing us to probe polarization -- and thus magnetic field orientation -- in the innermost regions surrounding the protostar. The collapse of strongly magnetized dense gas is predicted to pinch the magnetic field into an hourglass shape that persists down to scales <100 AU. However, in contrast with more than 50 years of theory, the ALMA data definitively rule out an hourglass morphology and instead reveal a chaotic magnetic field that has not been inherited from the field in the interstellar medium surrounding the source. We have simulated the star formation process with cutting-edge, moving-mesh AREPO simulations on scales from a million AU (5 pc) down to 60 AU. We find that only in the case of a very strong magnetic field (~100 microgauss on 5 pc scales) is the field direction preserved from cloud to disk scales. When the field is weak, turbulence in the interstellar gas shapes the field on large scales, and the forming star system re-shapes the field again on small scales, divorcing the field from its history on larger scales. We conclude that this is what has happened in Ser-emb 8. The main distinction from the strong-field star formation model is that in the weak-field case it is turbulence -- not the magnetic field -- that shapes the material that forms the protostar.

  7. Next Generation Forest Structure Measurements from Space: Synergism of NASA's NISAR and GEDI Observations

    NASA Astrophysics Data System (ADS)

    Saatchi, S. S.; Xu, L.; Yu, Y.

    2016-12-01

    Post-2020 will witness a series of new observations from NASA and ESA spaceborne missions dedicated to measurements of aboveground forest structure and biomass (AGB). These measurements are designed to significantly reduce the uncertainty in terrestrial carbon cycle by providing globally consistent estimates of forest aboveground carbon stocks and dynamics from land use and climate related changes. NASA's Global Ecosystem Dynamics Investigation (GEDI), NASA and ISRO SAR (NISAR), and ESA's BIOMASS (launch in 2020-21) missions, which are scheduled for launch in the next three to five years, share similar objectives for estimation of forest structure and aboveground biomass (AGB). The NISAR mission will measure above ground woody vegetation biomass at spatial resolution of 100 m (1-ha) annually over the lifetime of the mission providing fine grain products of carbon stocks and changes over a range of biomass limited to 100 Mg/ha. The upper threshold of 100 Mg/ha is set to reflect the sensitivity of L-band backscatter measurements to biomass and allowing coverage of more than 50% of the global forests and the entire area of remaining woody vegetation. This sensitivity will allow NISAR to quantify the carbon stocks and changes of the most dynamic and variable component of global vegetation with significant contribution to the global carbon cycle and climate science. We examine the sensitivity of NISAR in estimating AGB in different forest types and demonstrate how the NISAR and GEDI data can be combined in a machine-learning algorithm to develop synergistic products of global forest height and AGB. The synergistic approach extends the range of biomass estimation for NISAR mission and allows extrapolation of GEDI LiDAR samples to contiguous maps of height metrics. AcknowledgementsThe research was carried out partially at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration.

  8. Transient Phase of Ice Observed by Sum Frequency Generation at the Water/Mineral Interface During Freezing.

    PubMed

    Lovering, Kaitlin A; Bertram, Allan K; Chou, Keng C

    2017-02-16

    We observed a transient noncentrosymmetric phase of ice at water/mineral interfaces during freezing, which enhanced the intensity of the IR-visible sum frequency generation intensity by up to 20-fold. The lifetime of the transient phase was several minutes. Since the most stable form of ice, hexagonal and cubic ice, are centrosymmetric, our study suggests the transient existence of stacking-disordered ice during the freezing process at water/mineral interfaces. Stacking-disordered ice, which has only been observed in bulk ice at temperatures lower than -20 °C, is a random mixture of layers of hexagonal ice and cubic ice. However, the transient phase at the ice/mineral interface was observed at temperatures as high as -1 °C. It suggests that the mineral surface may play a role in promoting and stabilizing the formation of stacking-disordered ice at the interface.

  9. Threshold of wave generation on Titan’s lakes and seas: Effect of viscosity and implications for Cassini observations

    NASA Astrophysics Data System (ADS)

    Lorenz, Ralph D.; Newman, Claire; Lunine, Jonathan I.

    2010-06-01

    Motivated by radar and near-infrared data indicating that Titan's polar lakes are extremely smooth, we consider the conditions under which a lake surface will be ruffled by wind to form capillary waves. We evaluate laboratory data on wind generation and derive, without scaling for surface tension effects, a threshold for pure methane/ethane of ˜0.5-1 m/s. However, we compute the physical properties of predicted Titan lake compositions using the National Institute for Standards Technology (NIST) code and note that dissolved amounts of C3 and C4 compounds are likely to make Titan lakes much more viscous than pure ethane or methane, even without allowing for suspended particulates which would increase the viscosity further. Wind tunnel experiments show a strong dependence of capillary wave growth on liquid viscosity, and this effect may explain the apparent absence so far of waves, contrary to prior expectations that generation of gravity waves by wind should be easy on Titan. On the other hand, we note that winds over Titan lakes predicted with the TitanWRF Global Circulation Model indicate radar observations so far have in any case been when winds have been low (˜0.5-0.7 m/s), possibly below the wave generation threshold, while peak winds during summer may reach 1-2 m/s. Thus observations of Titan's northern lakes during the coming years by the Cassini Solstice mission offer the highest probability of observing wind-roughening of lake surfaces, while observations of Ontario Lacus in the south will likely continue to show it to be flat and smooth.

  10. Analysis of time-of-arrival observations performed during ELF/VLF wave generation experiments at HAARP

    NASA Astrophysics Data System (ADS)

    Fujimaru, S.; Moore, R. C.

    2011-06-01

    Modulated high frequency (HF) heating of the lower ionosphere in the presence of auroral electrojet currents has become an important method for generating electromagnetic waves in the extremely-low frequency (ELF) and very-low frequency (VLF) bands. Recent research efforts focus on improving the efficiency of ELF/VLF wave generation. One method to do so involves the spatial mapping of modulated currents that result from HF heating for comparison with HF heating models. As a first step toward providing a spatial map of the modulated ionospheric currents, we introduce time-of-arrival (TOA) observations performed during a series of experimental research campaigns conducted at the High-frequency Active Auroral Research Program (HAARP) in Gakona, Alaska. The TOA method provides a measurement of the ELF/VLF amplitude and phase detected at a ground-based receiver as a function of time, and this information may be used to estimate the distribution of ELF/VLF source currents within the HF heated region. In an effort to test and improve the TOA method, the University of Florida conducted ELF/VLF wave generation experiments using the HAARP HF transmitter under varying ionospheric conditions and using various transmission formats. In this paper, we summarize our experimental results and compare observations with the predictions of a theoretical model.

  11. Evaluating Inuence of Power Output Fluctuation of Photovoltaic Power Generation Systems on LFC based on Multiple Observation of Insolation

    NASA Astrophysics Data System (ADS)

    Yanagawa, Shigeyuki; Kato, Takeyoshi; Tabata, Akimori; Suzuoki, Yasuo

    A large-scale installation of a photovoltaic power generation system (PV system) may cause some diculties in the operation of electric power systems. Taking into account a smoothing effect of power outputs of PV systems by dispersed installation, this paper discusses the LFC (Load Frequency Control) capacity for power output fluctuation of PV systems based on the insolation data simultaneously observed at 5 points around Nagoya, Japan. The main results are (1) the frequency deviation might not exceed the tolerance (0.05Hz)when the installed PV system is 2% of system capacity, which is Japan’s target value toward 2010, (2) when the larger capacity of PV system is installed, the frequency deviation would be larger than 0.05Hz, and the capacity of LFC generator must be increased, (3) the frequency deviation due to the installation of PV system might be larger in holiday with smaller electricity demand than in weekday.

  12. [Correlation of changes in bone marrow cell sensitivity to the clastogenic effect of thiotepa and fertility in CBA/LacY mice in successive inbred generations].

    PubMed

    Malashenko, A M; Ignat'eva, E L; Beskova, T B

    1997-12-01

    The causes of the significant increases in the sensitivity to of clastogenic effect of thio-TEPA in bone marrow cells of inbred CBA/LacY mice were studied. The increases were shown to be associated with decreased fertility. The fluctuations of fertility and the association of fertility and sensitivity with thio-TEPA were analyzed in foundation stocks (FSs) for 24 and 6 inbred generations, respectively. The stocks examined were obtained in the Laboratory of Experimental Biological Models and the Stolbovaya breeding facility. The correlation analysis revealed a significant association of fluctuations of the coefficient of fertility in two FSs (eta = 0.78 +/- 0.13) and a high negative correlation between fertility and mutagen sensitivity in inbred generations (r = -0.91 +/- 0.21). The comparison between the fluctuations of fertility for four generations revealed the same fluctuation period in CBA/LacY, DBA/2Y, and C57Bl/6JY mice. The detected phenomena were assumed to result from genetically determined regular fluctuations in genome functioning. This explained a number of observations and allowed several prognoses to be made.

  13. DNA alterations and effects on growth and reproduction in Daphnia magna during chronic exposure to gamma radiation over three successive generations.

    PubMed

    Parisot, Florian; Bourdineaud, Jean-Paul; Plaire, Delphine; Adam-Guillermin, Christelle; Alonzo, Frédéric

    2015-06-01

    This study examined chronic effects of external Cs-137 gamma radiation on Daphnia magna exposed over three successive generations (F0, F1 and F2) to environmentally relevant dose rates (ranging from 0.007 to 35.4 mGy h(-1)). Investigated endpoints included survival, growth, reproduction and DNA alterations quantified using random-amplified polymorphic DNA polymerase chain reaction (RAPD-PCR). Results demonstrated that radiation effects on survival, growth and reproduction increased in severity from generation F0 to generation F2. Mortality after 21 days at 35.4 mGy h(-1) increased from 20% in F0 to 30% in F2. Growth was affected by a slight reduction in maximum length at 35.4 mGy h(-1) in F0 and by reductions of 5 and 13% in growth rate, respectively, at 4.70 and 35.4 mGy h(-1) in F2. Reproduction was affected by a reduction of 19% in 21 day-fecundity at 35.4 mGy h(-1) in F0 and by a delay of 1.9 days in brood release as low as 0.070 mGy h(-1) in F2. In parallel, DNA alterations became significant at decreasing dose rates over the course of F0 (from 4.70 mGy h(-1) at hatching to 0.007 mGy h(-1) after ∼21 days) and from F0 to F2 (0.070 mGy h(-1) at hatching to 0.007 mGy h(-1) after ∼21 days), demonstrating their rapid accumulation in F0 daphnids and their transmission to offspring generations. Transiently more efficient DNA repair leading to some recovery at the organism level was suggested in F1, with no effect on survival, a slight reduction of 12% in 21 day-fecundity at 35.4 mGy h(-1) and DNA alterations significant at highest dose rates only. The study improved our understanding of long term responses to low doses of radiation at the molecular and organismic levels in a non-human species for a better radioprotection of aquatic ecosystems.

  14. Ling’s Adsorption Theory as a Mechanism of Membrane Potential Generation Observed in Both Living and Nonliving Systems

    PubMed Central

    Tamagawa, Hirohisa; Funatani, Makoto; Ikeda, Kota

    2016-01-01

    The potential between two electrolytic solutions separated by a membrane impermeable to ions was measured and the generation mechanism of potential measured was investigated. From the physiological point of view, a nonzero membrane potential or action potential cannot be observed across the impermeable membrane. However, a nonzero membrane potential including action potential-like potential was clearly observed. Those observations gave rise to a doubt concerning the validity of currently accepted generation mechanism of membrane potential and action potential of cell. As an alternative theory, we found that the long-forgotten Ling’s adsorption theory was the most plausible theory. Ling’s adsorption theory suggests that the membrane potential and action potential of a living cell is due to the adsorption of mobile ions onto the adsorption site of cell, and this theory is applicable even to nonliving (or non-biological) system as well as living system. Through this paper, the authors emphasize that it is necessary to reconsider the validity of current membrane theory and also would like to urge the readers to pay keen attention to the Ling’s adsorption theory which has for long years been forgotten in the history of physiology. PMID:26821050

  15. Ling's Adsorption Theory as a Mechanism of Membrane Potential Generation Observed in Both Living and Nonliving Systems.

    PubMed

    Tamagawa, Hirohisa; Funatani, Makoto; Ikeda, Kota

    2016-01-26

    The potential between two electrolytic solutions separated by a membrane impermeable to ions was measured and the generation mechanism of potential measured was investigated. From the physiological point of view, a nonzero membrane potential or action potential cannot be observed across the impermeable membrane. However, a nonzero membrane potential including action potential-like potential was clearly observed. Those observations gave rise to a doubt concerning the validity of currently accepted generation mechanism of membrane potential and action potential of cell. As an alternative theory, we found that the long-forgotten Ling's adsorption theory was the most plausible theory. Ling's adsorption theory suggests that the membrane potential and action potential of a living cell is due to the adsorption of mobile ions onto the adsorption site of cell, and this theory is applicable even to nonliving (or non-biological) system as well as living system. Through this paper, the authors emphasize that it is necessary to reconsider the validity of current membrane theory and also would like to urge the readers to pay keen attention to the Ling's adsorption theory which has for long years been forgotten in the history of physiology.

  16. Multiple-Station Observation of Frequency Dependence and Polarization Characteristics of ELF/VLF waves generated via Ionospheric Modification

    NASA Astrophysics Data System (ADS)

    Maxworth, A. S.; Golkowski, M.; Cohen, M.; Moore, R. C.

    2014-12-01

    Generation of Extremely Low Frequency (ELF) and Very Low Frequency (VLF) signals through ionospheric modification has been practiced for many years. Heating the lower ionosphere with high power HF waves allows for modulation of natural current systems. Our experiments were carried out at the High Frequency Active Auroral Research Program (HAARP) facility in Alaska, USA. In this experiment, the ionosphere was heated with a vertical amplitude modulating signal and the modulation frequency was changed sequentially within an array of 40 frequencies followed by a frequency ramp. The observed magnetic field amplitude and polarization of the generated ELF/VLF signals were analyzed for multiple sites and as a function of modulation frequency. Our three observation sites: Chistochina, Paxson and Paradise are located within 36km (azimuth 47.7°), 50.2km (azimuth -20°) and 99km (azimuth 80.3°) respectively. We show that the peak amplitudes observed as a function of frequency result from vertical resonance in the Earth-ionosphere waveguide and can be used to diagnose the D-region profile. Polarization analysis showed that out of the three sites Paxson shows the highest circularity in the magnetic field polarization, compared to Chistochina and Paradise which show highly linear polarizations. The experimental results were compared with a theoretical simulation model results and it was clear that in both cases, the modulated Hall current dominates the observed signals at Chistochina and Paradise sites and at Paxson there is an equal contribution from Hall and Pedersen currents. The Chistochina site shows the highest magnetic field amplitudes in both experimental and simulation environments. Depending upon the experimental and simulation observations at the three sites, a radiation pattern for the HAARP ionospheric heater can be mapped

  17. Direct observation of bulk second-harmonic generation inside a glass slide with tightly focused optical fields

    NASA Astrophysics Data System (ADS)

    Wang, Xianghui; Fardad, Shima; Das, Susobhan; Salandrino, Alessandro; Hui, Rongqing

    2016-04-01

    Bulk second-harmonic generation (SHG) inside glass slides is directly detected unambiguously without interference from surface contributions. This is enabled by tightly focused and highly localized ultrashort laser pulses. The theoretical calculations based on vector diffraction theory and the phenomenological model of SHG inside centrosymmetric materials agree well with the measured far-field SHG radiation patterns for different polarization states of the fundamental beam. The results indicate that the observed bulk SHG is predominantly related to the bulk parameter δ' and originates from the three-dimensional field gradient in the focal region.

  18. Observation of self-similarity in the magnetic fields generated by the ablative nonlinear Rayleigh-Taylor instability.

    PubMed

    Gao, L; Nilson, P M; Igumenschev, I V; Fiksel, G; Yan, R; Davies, J R; Martinez, D; Smalyuk, V; Haines, M G; Blackman, E G; Froula, D H; Betti, R; Meyerhofer, D D

    2013-05-03

    Magnetic fields generated by the nonlinear Rayleigh-Taylor growth of laser-seeded three-dimensional broadband perturbations were measured in laser-accelerated planar targets using ultrafast proton radiography. The experimental data show self-similar behavior in the growing cellular magnetic field structures. These observations are consistent with a bubble competition and merger model that predicts the time evolution of the number and size of the bubbles, linking the cellular magnetic field structures with the Rayleigh-Taylor bubble and spike growth.

  19. On the observation of a flare-generated shock wave at 9.7 AU by Pioneer 10

    NASA Technical Reports Server (NTRS)

    Dryer, M.; Shea, M. A.; Smart, D. F.; Collard, H. R.; Mihalov, J. D.; Wolfe, J. H.; Warwick, J. W.

    1978-01-01

    An apparent solar-flare-generated shock wave detected by Pioneer-10 at 9.7 AU on April 9, 1976 is discussed. The shock wave may be correlated with a radio emission burst from Jupiter not associated with Io (March 30). The fact that solar flares observed on March 20 were at the central meridian with respect to Jupiter and Pioneer-10 and the fact that solar activity was very low before March 20 contribute to the argument that a shock wave had propagated to the region of the spacecraft.

  20. Assimilation of Smos Observations to Generate a Prototype SMAP Level 4 Surface and Root-Zone Soil Moisture Product

    NASA Technical Reports Server (NTRS)

    Reichle, Rolf H.; De Lannoy, Gabrielle J. M.; Crow, Wade T.; Koster, Randal D.; Kimball, John

    2012-01-01

    The Soil Moisture Active and Passive (SMAP; [1]) mission is being implemented by NASA for launch in October 2014. The primary science objectives of SMAP are to enhance understanding of land surface controls on the water, energy and carbon cycles, and to determine their linkages. Moreover, the high-resolution soil moisture mapping provided by SMAP has practical applications in weather and seasonal climate prediction, agriculture, human health, drought and flood decision support. The Soil Moisture and Ocean Salinity (SMOS; [2]) mission was launched by ESA in November 2009 and has since been observing L-band (1.4 GHz) upwelling passive microwaves. In this paper we describe our use of SMOS brightness temperature observations to generate a prototype of the planned SMAP Level 4 Surface and Root-zone Soil Moisture (L4_SM) product [5].

  1. Observation of two polytypes of MoS2 ultrathin layers studied by second harmonic generation microscopy and photoluminescence

    NASA Astrophysics Data System (ADS)

    Mishina, E.; Sherstyuk, N.; Lavrov, S.; Sigov, A.; Mitioglu, A.; Anghel, S.; Kulyuk, L.

    2015-03-01

    Second harmonic generation (SHG) of a high intensity was found in MoS2 flakes of different thicknesses exfoliated on a silicon substrate. Reduction of the SHG intensity was observed only for a small portion of flakes, for both very thin and quite thick ones. This was attributed to the presence of polytypism, i.e., of 3R non-centrosymmetric and 2H centrosymmetric polytypes, in a source bulk crystal grown by the chemical vapor transport technique. The presence of two polytypes in the sample was confirmed by the spectral structure of the photoluminescence of bound excitons observed in flakes at low temperature. Absolute values of nonlinear susceptibility of MoS2 flakes of different thicknesses were estimated.

  2. Simultaneous observation of cavitation bubbles generated in biological tissue by high-speed optical and acoustic imaging methods

    NASA Astrophysics Data System (ADS)

    Suzuki, Kai; Iwasaki, Ryosuke; Takagi, Ryo; Yoshizawa, Shin; Umemura, Shin-ichiro

    2017-07-01

    Acoustic cavitation bubbles are useful for enhancing the heating effect in high-intensity focused ultrasound (HIFU) treatment. Many studies were conducted to investigate the behavior of such bubbles in tissue-mimicking materials, such as a transparent gel phantom; however, the detailed behavior in tissue was still unclear owing to the difficulty in optical observation. In this study, a new biological phantom was developed to observe cavitation bubbles generated in an optically shallow area of tissue. Two imaging methods, high-speed photography using light scattering and high-speed ultrasonic imaging, were used for detecting the behavior of the bubbles simultaneously. The results agreed well with each other for the area of bubble formation and the temporal change in the region of bubbles, suggesting that both methods are useful for visualizing the bubbles.

  3. Generation, Diffraction and Radiation of Subsonic Flexural Waves on Membranes and Plates: Observations of Structural and Acoustical Wavefields.

    NASA Astrophysics Data System (ADS)

    Matula, Thomas John

    Electromagnetic acoustic wave transducers (EMATs) are described for generating low-frequency tone bursts on metalized membranes in air and elastic plates in water. Bursts on the membrane have phase velocities much less than the speed of sound in the surrounding air and are accompanied by plane evanescent waves. The frequency and time-domain responses of the EMAT and the dependence on gap spacing between the coupling coil and the membrane were studied. Wave -number selective optical and capacitive probes were used to measure the wave properties. Versions of these transducers are insensitive to long wavelength motion of the membrane. Diffraction of the burst by a sharp edge in air was observed as a function of the gap between the membrane and a razor edge. The scattered pressure decreases exponentially with increasing gap as expected from an approximate analysis of edge diffraction of evanescent waves. In related work an EMAT is used to generate 28 kHz tone bursts of bending waves on an aluminum plate. The bursts propagate down into water where the surrounding wavefield is probed. Observations described indicate that there occurs a branching of energy as the wave crosses the air-water interface. Radiation from subsonic flexural plate waves due to the discontinuity in fluid -loading is observed. It is partially analogous to the transition radiation of fast charged particles crossing a dielectric interface. The angular radiation pattern resembles that of a line quadrupole. Near the interface there exists an interference between the two energy branches in water that produces a series of pressure nulls. The pressure nulls are associated with a pi phase change in the wavefield and are indicators of wavefront dislocations. A computation of the wavefield in an unbounded fluid due to a line-moment excitation of a plate is comparable with the null pattern observed but differs in certain details.

  4. A Novel Controller Design for the Next Generation Space Electrostatic Accelerometer Based on Disturbance Observation and Rejection.

    PubMed

    Li, Hongyin; Bai, Yanzheng; Hu, Ming; Luo, Yingxin; Zhou, Zebing

    2016-12-23

    The state-of-the-art accelerometer technology has been widely applied in space missions. The performance of the next generation accelerometer in future geodesic satellites is pushed to 8 × 10 - 13 m / s 2 / H z 1 / 2 , which is close to the hardware fundamental limit. According to the instrument noise budget, the geodesic test mass must be kept in the center of the accelerometer within the bounds of 56 pm / Hz 1 / 2 by the feedback controller. The unprecedented control requirements and necessity for the integration of calibration functions calls for a new type of control scheme with more flexibility and robustness. A novel digital controller design for the next generation electrostatic accelerometers based on disturbance observation and rejection with the well-studied Embedded Model Control (EMC) methodology is presented. The parameters are optimized automatically using a non-smooth optimization toolbox and setting a weighted H-infinity norm as the target. The precise frequency performance requirement of the accelerometer is well met during the batch auto-tuning, and a series of controllers for multiple working modes is generated. Simulation results show that the novel controller could obtain not only better disturbance rejection performance than the traditional Proportional Integral Derivative (PID) controllers, but also new instrument functions, including: easier tuning procedure, separation of measurement and control bandwidth and smooth control parameter switching.

  5. Observations of amplitude saturation in ELF/VLF wave generation by modulated HF heating of the auroral electrojet

    NASA Astrophysics Data System (ADS)

    Moore, R. C.; Inan, U. S.; Bell, T. F.

    2006-06-01

    We present detailed observations of the onset of amplitude saturation in ELF/VLF waves generated via modulated HF heating of naturally-forming, large-scale current systems, such as the auroral electrojet. Broadband ELF/VLF measurements at a ground-based receiver located near the High-Frequency Active Auroral Research Program (HAARP) HF transmitter in Gakona, Alaska, exhibit variations in signal amplitude which are qualitatively consistent with a hard-limiting approximation of the saturation process. A method to approximate the saturation curve as a function of HF power from experimental data is presented, and the results indicate that a ~5-10% reduction in generated ELF signal amplitude is typical at the maximum radiated HF power level (771 kW) for modulation frequencies between 1225 Hz and 3365 Hz. For HF transmissions using sinusoidal amplitude modulation, the saturation dominantly affects the second harmonic of the generated ELF/VLF signal, with amplitudes on average 16% lower than expected at the maximum HF power level.

  6. Signal template generation from acquired mammographic images for the non-prewhitening model observer with eye-filter

    NASA Astrophysics Data System (ADS)

    Balta, Christiana; Bouwman, Ramona W.; Sechopoulos, Ioannis; Broeders, Mireille J. M.; Karssemeijer, Nico; van Engen, Ruben E.; Veldkamp, Wouter J. H.

    2017-03-01

    Model observers (MOs) are being investigated for image quality assessment in full-field digital mammography (FFDM). Signal templates for the non-prewhitening MO with eye filter (NPWE) were formed using acquired FFDM images. A signal template was generated from acquired images by averaging multiple exposures resulting in a low noise signal template. Noise elimination while preserving the signal was investigated and a methodology which results in a noise-free template is proposed. In order to deal with signal location uncertainty, template shifting was implemented. The procedure to generate the template was evaluated on images of an anthropomorphic breast phantom containing microcalcification-related signals. Optimal reduction of the background noise was achieved without changing the signal. Based on a validation study in simulated images, the difference (bias) in MO performance from the ground truth signal was calculated and found to be <1%. As template generation is a building stone of the entire image quality assessment framework, the proposed method to construct templates from acquired images facilitates the use of the NPWE MO in acquired images.

  7. A Novel Controller Design for the Next Generation Space Electrostatic Accelerometer Based on Disturbance Observation and Rejection

    PubMed Central

    Li, Hongyin; Bai, Yanzheng; Hu, Ming; Luo, Yingxin; Zhou, Zebing

    2016-01-01

    The state-of-the-art accelerometer technology has been widely applied in space missions. The performance of the next generation accelerometer in future geodesic satellites is pushed to 8×10−13m/s2/Hz1/2, which is close to the hardware fundamental limit. According to the instrument noise budget, the geodesic test mass must be kept in the center of the accelerometer within the bounds of 56 pm/Hz1/2 by the feedback controller. The unprecedented control requirements and necessity for the integration of calibration functions calls for a new type of control scheme with more flexibility and robustness. A novel digital controller design for the next generation electrostatic accelerometers based on disturbance observation and rejection with the well-studied Embedded Model Control (EMC) methodology is presented. The parameters are optimized automatically using a non-smooth optimization toolbox and setting a weighted H-infinity norm as the target. The precise frequency performance requirement of the accelerometer is well met during the batch auto-tuning, and a series of controllers for multiple working modes is generated. Simulation results show that the novel controller could obtain not only better disturbance rejection performance than the traditional Proportional Integral Derivative (PID) controllers, but also new instrument functions, including: easier tuning procedure, separation of measurement and control bandwidth and smooth control parameter switching. PMID:28025534

  8. A cross sectional observational study of research activity of allied health teams: is there a link with self-reported success, motivators and barriers to undertaking research?

    PubMed

    Wenke, Rachel J; Mickan, Sharon; Bisset, Leanne

    2017-02-06

    Team-based approaches to research capacity building (RCB) may be an efficient means to promote allied health research participation and activity. In order to tailor such interventions, a clearer understanding of current patterns of research participation within allied health teams is needed. Different self-report measures exist which evaluate a team's research capacity and participation, as well as associated barriers and motivators. However, it remains unclear how such measures are associated with a team's actual research activity (e.g., journal publications, funding received). In response, this observational study aimed to identify the research activity, self-reported success, and motivations and barriers to undertaking research of eight allied health professional (AHP) teams and to explore whether any relationships exist between the self-reported measures and actual research activity within each team. A total of 95 AHPs from eight teams completed the research capacity and culture survey to evaluate team success, barriers and motivators to undertaking research, and an audit of research activity from January 2013 to August 2014 was undertaken within each team. Kendell's correlation coefficients were used to determine the association between research activity (i.e., number of journal publications, ethically approved projects and funding received) and the self-reported measures. Seven out of eight teams rated their teams as having average success in research and demonstrated some form of research activity including at least two ethically approved projects. Research activity varied between teams, with funding received ranging from $0 to over $100,000, and half the teams not producing any journal publications. Team motivators demonstrated a stronger association with research activity compared to barriers, with the motivator "enhancing team credibility" being significantly associated with funding received. No significant association between self-reported research

  9. Demand generation and social mobilisation for integrated community case management (iCCM) and child health: Lessons learned from successful programmes in Niger and Mozambique.

    PubMed

    Sharkey, Alyssa B; Martin, Sandrine; Cerveau, Teresa; Wetzler, Erica; Berzal, Rocio

    2014-12-01

    We present the approaches used in and outcomes resulting from integrated community case management (iCCM) programmes in Niger and Mozambique with a strong focus on demand generation and social mobilisation. We use a case study approach to describe the programme and contextual elements of the Niger and Mozambique programmes. Awareness and utilisation of iCCM services and key family practices increased following the implementation of the Niger and Mozambique iCCM and child survival programmes, as did care-seeking within 24 hours and care-seeking from appropriate, trained providers in Mozambique. These approaches incorporated interpersonal communication activities and community empowerment/participation for collective change, partnerships and networks among key stakeholder groups within communities, media campaigns and advocacy efforts with local and national leaders. iCCM programmes that train and equip community health workers and successfully engage and empower community members to adopt new behaviours, have appropriate expectations and to trust community health workers' ability to assess and treat illnesses can lead to improved care-seeking and utilisation, and community ownership for iCCM.

  10. Demand generation and social mobilisation for integrated community case management (iCCM) and child health: Lessons learned from successful programmes in Niger and Mozambique

    PubMed Central

    Sharkey, Alyssa B; Martin, Sandrine; Cerveau, Teresa; Wetzler, Erica; Berzal, Rocio

    2014-01-01

    Aim We present the approaches used in and outcomes resulting from integrated community case management (iCCM) programmes in Niger and Mozambique with a strong focus on demand generation and social mobilisation. Methods We use a case study approach to describe the programme and contextual elements of the Niger and Mozambique programmes. Results Awareness and utilisation of iCCM services and key family practices increased following the implementation of the Niger and Mozambique iCCM and child survival programmes, as did care–seeking within 24 hours and care–seeking from appropriate, trained providers in Mozambique. These approaches incorporated interpersonal communication activities and community empowerment/participation for collective change, partnerships and networks among key stakeholder groups within communities, media campaigns and advocacy efforts with local and national leaders. Conclusions iCCM programmes that train and equip community health workers and successfully engage and empower community members to adopt new behaviours, have appropriate expectations and to trust community health workers’ ability to assess and treat illnesses can lead to improved care–seeking and utilisation, and community ownership for iCCM. PMID:25520800

  11. Endophthalmitis after uncomplicated cataract surgery with the use of fourth-generation fluoroquinolones: a retrospective observational case series.

    PubMed

    Moshirfar, Majid; Feiz, Vahid; Vitale, Albert T; Wegelin, Jacob A; Basavanthappa, Screenivasa; Wolsey, Darcey H

    2007-04-01

    To estimate the rate of acute postoperative endophthalmitis after uncomplicated cataract surgery in patients treated before and after surgery with 1 of 2 different fourth-generation fluoroquinolone ophthalmic drops for surgical prophylaxis. Retrospective, multicenter, observational case series. Included in this study were 20,013 patients from 9 cataract surgery centers in 7 states in the United States. Patients who had undergone uncomplicated phacoemulsification who received preoperative and postoperative topical fourth-generation fluoroquinolones for surgical prophylaxis between March 2003 and July 2005 were included in the study. The files of patients in whom acute endophthalmitis developed were reviewed and analyzed. Number and rate of endophthalmitis cases after uncomplicated cataract surgery. During the study period, the participating surgeons performed 20,013 uncomplicated surgeries. Of these, 16,209 patients (81%) received topical gatifloxacin and 3804 patients (19%) were treated with topical moxifloxacin as antiinfective prophylaxis. A total of 14 patients experienced endophthalmitis. The overall rate of endophthalmitis was 0.07%. There were 9 endophthalmitis patients in the gatifloxacin group and 5 endophthalmitis patients in the moxifloxacin group. The rate of endophthalmitis in the gatifloxacin group was 0.06% and the rate in the moxifloxacin group was 0.1%. The difference in the rate of endophthalmitis between the 2 groups was not statistically significant. In 10 of the patients, vitreous culture results were positive. Coagulase-negative staphylococci, followed by streptococci, species were the most commonly isolated organisms in the culture-positive patients. The overall rate of endophthalmitis after uncomplicated cataract surgery in patients treated with topical fourth-generation fluoroquinolones as antiinfective prophylaxis was 0.07%. This rate was within the range of previously reported rates of endophthalmitis in the literature. The difference in

  12. Comparison of Pd/D co-deposition and DT neutron generated triple tracks observed in CR-39 detectors

    SciTech Connect

    Mosier-Boss, P. A.; Dea, J. Y.; Forsley, L. P. G.; Morey, M. S.; Tinsley, J. R.; Hurley, J. P.; Gordon, F. E.

    2010-08-01

    Solid state nuclear track detectors (SSNTDs), such as CR-39, have been used to detect energetic charged particles and neutrons. Of the neutron and charged particle interactions that can occur in CR-39, the one that is the most easily identifiable is the carbon breakup reaction. The observation of a triple track, which appears as three alpha particle tracks breaking away from a center point, is diagnostic of the 12C(n, n')3α carbon breakup reaction. Such triple tracks have been observed in CR-39 detectors that have been used in Pd/D co-deposition experiments. In this communication, triple tracks in CR-39 detectors observed in Pd/D co-deposition experiments are compared with those generated upon exposure to a DT neutron source. It was found that both sets of tracks were indistinguishable. Both symmetric and asymmetric tracks were observed. Using linear energy transfer (LET) curves and track modeling, the energy of the neutron that created the triple track can be estimated.

  13. Observation of tsunami-generated ionospheric signatures over Hawaii caused by the 16 September 2015 Illapel earthquake

    NASA Astrophysics Data System (ADS)

    Grawe, Matthew A.; Makela, Jonathan J.

    2017-01-01

    Tsunamis generate internal gravity waves (IGWs) that propagate vertically into the atmosphere and can create detectable signatures in the ionosphere. These signatures have consistently been observed in the presence of a tsunami for over a decade in the total electron content and for over 5 years in the 630.0 nm airglow. Here we show perturbations appearing in filtered GPS-derived total electron content (TEC) and 630.0 nm airglow above Hawaii during the passing of the tsunami induced by the 16 September 2015 earthquake in Illapel, Chile. We report measurements of IGW parameters from both observation methodologies using a combination of prior methods and a newly developed method that uses a Gabor filter bank. A previously developed geometric model that takes into account the assumed posture of tsunami-induced IGWs in the geomagnetic field and the observation geometry is shown to predict fairly well the expected location of the observation in the sky. Results of the Gabor filtering technique are also compared to previously published results for the 11 March 2011 Tohoku event. An overall comparison between all of the tsunami-induced signatures that have appeared in both the 630.0 nm airglow and TEC above Hawaii to date is provided.

  14. Development, Application, and Transition of Aerosol and Trace Gas Products Derived from Next-Generation Satellite Observations to Operations

    NASA Technical Reports Server (NTRS)

    Berndt, Emily; Naeger, Aaron; Zavodsky, Bradley; McGrath, Kevin; LaFontaine, Frank

    2016-01-01

    NASA Short-term Prediction Research and Transition (SPoRT) Center has a history of successfully transitioning unique observations and research capabilities to the operational weather community to improve short-term forecasts. SPoRTstrives to bridge the gap between research and operations by maintaining interactive partnerships with end users to develop products that match specific forecast challenges, provide training, and assess the products in the operational environment. This presentation focuses on recent product development, application, and transition of aerosol and trace gas products to operations for specific forecasting applications. Recent activities relating to the SPoRT ozone products, aerosol optical depth composite product, sulfur dioxide, and aerosol index products are discussed.

  15. Success rate and risk factors for failure of empirical antifungal therapy with itraconazole in patients with hematological malignancies: a multicenter, prospective, open-label, observational study in Korea.

    PubMed

    Kim, Soo-Jeong; Cheong, June-Won; Min, Yoo Hong; Choi, Young Jin; Lee, Dong-Gun; Lee, Je-Hwan; Yang, Deok-Hwan; Lee, Sang Min; Kim, Sung-Hyun; Kim, Yang Soo; Kwak, Jae-Yong; Park, Jinny; Kim, Jin Young; Kim, Hoon-Gu; Kim, Byung Soo; Ryoo, Hun-Mo; Jang, Jun Ho; Kim, Min Kyoung; Kang, Hye Jin; Cho, In Sung; Mun, Yeung Chul; Jo, Deog-Yeon; Kim, Ho Young; Park, Byeong-Bae; Kim, Jin Seok

    2014-01-01

    We assessed the success rate of empirical antifungal therapy with itraconazole and evaluated risk factors for predicting the failure of empirical antifungal therapy. A multicenter, prospective, observational study was performed in patients with hematological malignancies who had neutropenic fever and received empirical antifungal therapy with itraconazole at 22 centers. A total of 391 patients who had abnormal findings on chest imaging tests (31.0%) or a positive result of enzyme immunoassay for serum galactomannan (17.6%) showed a 56.5% overall success rate. Positive galactomannan tests before the initiation of the empirical antifungal therapy (P=0.026, hazard ratio [HR], 2.28; 95% confidence interval [CI], 1.10-4.69) and abnormal findings on the chest imaging tests before initiation of the empirical antifungal therapy (P=0.022, HR, 2.03; 95% CI, 1.11-3.71) were significantly associated with poor outcomes for the empirical antifungal therapy. Eight patients (2.0%) had premature discontinuation of itraconazole therapy due to toxicity. It is suggested that positive galactomannan tests and abnormal findings on the chest imaging tests at the time of initiation of the empirical antifungal therapy are risk factors for predicting the failure of the empirical antifungal therapy with itraconazole. (Clinical Trial Registration on National Cancer Institute website, NCT01060462).

  16. Observations of Traveling Ionospheric Disturbances (TIDs) Over the United States Associated With the Tsunami Generated by the 2011 Tohoku Earthquake

    NASA Astrophysics Data System (ADS)

    Duly, T. M.; Azeem, I.; Crowley, G.; Vadas, S.; Makela, J. J.; Reynolds, A.

    2015-12-01

    The March 11, 2011 Tohoku earthquake generated a massive tsunami off the Pacific coast of Japan which in turn forced intense atmospheric gravity waves (AGW) that were seen in GPS Total Electron Content (TEC) data and airglow measurements as traveling ionospheric disturbance (TID) signatures as far away as Hawaii. What is unknown is how far these TIDs traveled after being launched by the tsunami and the role of the underlying neutral atmosphere on their propagation characteristics. For the first time, we show that TIDs associated with the Tohoku tsunami were observed in GPS TEC data for several hours over the west coast of the US and as far inland as Colorado. The results presented here show a range of TIDs generated by gravity wave packets propagating into the ionosphere from below. We present results indicating the presence of TIDs with periods ranging from 15 to 30 minutes, and horizontal wavelengths from 150 km to 400 km. The azimuth of the observed TID wave train was 121.8 ± 1.8° (angle measured in degrees east of north), which matches the azimuth of the tsunami near the Pacific coast of the US. The observed period of the TIDs was one of the spectral components of the tsunami wave packet as it approached the Pacific coast of the US. These results suggest that the tsunami was the source of the TIDs over the US. Additionally, the TID periods and horizontal wavelengths clearly vary in longitude. These variations agree with theoretical gravity wave results concerning propagation and dissipation in the thermosphere.

  17. A Rapid Prototyping Look at NASA's Next Generation Earth-Observing Satellites; Opportunities for Global Change Research and Applications

    NASA Astrophysics Data System (ADS)

    Cecil, L.; Young, D. F.; Parker, P. A.; Eckman, R. S.

    2006-12-01

    The NASA Applied Sciences Program extends the results of Earth Science Division (ESD) research and knowledge beyond the scientific and research communities to contribute to national priority applications with societal benefits. The Applied Sciences Program focuses on, (1) assimilation of NASA Earth-science research results and their associated uncertainties to improve decision support systems and, (2) the transition of NASA research results to evolve improvements in future operational systems. The broad range of Earth- science research results that serve as inputs to the Applied Sciences Program are from NASA's Research and Analysis Program (R&A) within the ESD. The R&A Program has established six research focus areas to study the complex processes associated with Earth-system science; Atmospheric Composition, Carbon Cycle and Ecosystems, Climate Variability and Change, Earth Surface and Interior, Water and Energy Cycle, and Weather. Through observations-based Earth-science research results, NASA and its partners are establishing predictive capabilities for future projections of natural and human perturbations on the planet. The focus of this presentation is on the use of research results and their associated uncertainties from several of NASA's nine next generation missions for societal benefit. The newly launched missions are, (1) CloudSat, and (2) CALIPSO (Cloud Aerosol Lidar and Infrared Pathfinder Satellite Observations), both launched April 28, 2006, and the planned next generation missions include, (3) the Orbiting Carbon Observatory (OCO), (4) the Global Precipitation Mission (GPM), (5) the Landsat Data Continuity Mission (LDCM), (6) Glory, for measuring the spatial and temporal distribution of aerosols and total solar irradiance for long-term climate records, (7) Aquarius, for measuring global sea surface salinity, (8) the Ocean Surface Topography Mission (OSTM), and (9) the NPOESS Preparatory Project (NPP) for measuring long-term climate trends and global

  18. Targeted Next-Generation Sequencing for Human Leukocyte Antigen Typing in a Clinical Laboratory: Metrics of Relevance and Considerations for Its Successful Implementation.

    PubMed

    Gandhi, Manish J; Ferriola, Deborah; Huang, Yanping; Duke, Jamie L; Monos, Dimitri

    2017-06-01

    - Numerous feasibility studies to type human leukocyte antigens (HLAs) by next-generation sequencing (NGS) have led to the development of vendor-supported kits for HLA typing by NGS. Some clinical laboratories have introduced HLA-NGS, and many are investigating the introduction. Standards from accrediting agencies form the regulatory framework for introducing this test into clinical laboratories. - To provide an assessment of metrics and considerations relevant to the successful implementation of clinical HLA-NGS typing, and to provide as a reference a validated HLA-NGS protocol used clinically since December 2013 at the Children's Hospital of Philadelphia (Philadelphia, Pennsylvania). - The HLA-NGS has been performed on 2532 samples. The initial 1046 and all homozygous samples were also typed by an alternate method. The HLA-NGS demonstrated 99.7% concordance with the alternate method. Ambiguous results were most common at the DPB1 locus because of a lack of phasing between exons 2 and 3 or the unsequenced exon 1 (533 of 2954 alleles; 18.04%) and the DRB1 locus because of not sequencing exon 1 (75 of 3972 alleles; 1.89%). No ambiguities were detected among the other loci. Except for 2 false homozygous samples, all homozygous samples (1891) demonstrated concordance with the alternate method. The article is organized to address the critical elements in the preanalytic, analytic, and postanalytic phases of introducing this assay into the clinical laboratory. - The results demonstrate that HLA typing by NGS is a highly accurate, reproducible, efficient method that provides more-complete sequencing information for the length of the HLA gene and can be the single methodology for HLA typing in clinical immunogenetics laboratories.

  19. Correlations of life-span variation parameters in 128 successive generations of Drosophila melanogaster with changes in atmospheric pressure and geomagnetic activity.

    PubMed

    Izmaylov, D M; Obukhova, L K; Konradov, A A

    2005-05-01

    Correlations between the parameters of life-span (LS) distribution of Drosophila melanogaster, including mean LS (MLS) and the time of 10 and 90% population mortality, and some geophysical parameters that are usually beyond the control of researchers dealing with laboratory cultures, including atmospheric pressure, solar activity indices (Wolf's sunspot numbers and 2,800-MHz radio flux), and geomagnetic activity (planetary index, K(p)), were studied. Geophysical data were obtained from free-access official web sites of the National Oceanic & Atmospheric Administration of the US Department of Commerce and the Institute of Terrestrial Magnetism and Radiowave Propagation of the Russian Academy of Sciences. The geophysical parameters were calculated only for the period corresponding to 10 days of preimaginal development of the flies from egg to imago. Canonical correlation analysis, calculation of the non-parametric Spearman rank-order correlation coefficients, and graphical data analysis were used. Highly significant correlations between parameters of LS distribution in males and females and environmental factors, such as the atmospheric pressure on the 4th and 5th day of development and geomagnetic activity indices (K(p)) on the 6th and 10th day of development were found, with correlation coefficients varying from 0.31 to 0.37 (P<0.02). Assuming a causal relationship between geophysical factors and LS, it may be hypothesized that energetically weak environmental factors determine the formation of LS oscillatory dynamics in laboratory populations. The possible mechanisms underlying the contribution of these environmental factors to the LS variation in successive generations are discussed.

  20. An algorithm to generate input data from meteorological and space shuttle observations to validate a CH4-CO model

    NASA Technical Reports Server (NTRS)

    Peters, L. K.; Yamanis, J.

    1981-01-01

    Objective procedures to analyze data from meteorological and space shuttle observations to validate a three dimensional model were investigated. The transport and chemistry of carbon monoxide and methane in the troposphere were studied. Four aspects were examined: (1) detailed evaluation of the variational calculus procedure, with the equation of continuity as a strong constraint, for adjustment of global tropospheric wind fields; (2) reduction of the National Meteorological Center (NMC) data tapes for data input to the OSTA-1/MAPS Experiment; (3) interpolation of the NMC Data for input to the CH4-CO model; and (4) temporal and spatial interpolation procedures of the CO measurements from the OSTA-1/MAPS Experiment to generate usable contours of the data.

  1. A multichannel time-of-flight system for observation of energetic ions of multispecies generated from relativistic laser plasma

    SciTech Connect

    Matsukado, K.; Fujimoto, M.; Takahashi, H.; Kawada, Y.; Ohsuka, S.; Aoshima, S.

    2010-02-15

    A multichannel time-of-flight (TOF) system was constructed to observe the ions generated from relativistic laser plasma, where the ions have polychromatic energies and multiple species. The TOF system is composed of a ten-channel scintillation detector array and an electromagnet that generates a magnetic field of 0-1.24 T. The magnet field enables us to analyze protons, deuterons, and full-stripped carbon ions to 50, 25, and 150 MeV, respectively. The system experimentally identified protons of 0.27-1.6 MeV energy and ions of a half specific charge (deuterons of 0.3-0.8 MeV and full-stripped carbons of 1.8-4.8 MeV). The measured TOF values agree well with the calculated values within the designed accuracy; {+-}2.5 ns for protons and {+-}5 ns for the others (d or C{sup 6+}) on each detector channel. Comparison of ion numbers detected by a track detector (CR-39) and the TOF system enabled us to obtain the number of ions detected on each scintillation counter with less than 16% error.

  2. High-speed observation of bubble cloud generation near a rigid wall by second-harmonic superimposed ultrasound.

    PubMed

    Yoshizawa, Shin; Yasuda, Jun; Umemura, Shin-ichiro

    2013-08-01

    Cavitation bubbles are known to accelerate therapeutic effects of ultrasound. Although negative acoustic pressure is the principle factor of cavitation, positive acoustic pressure has a role for bubble cloud formation at a high intensity of focused ultrasound when cavitation bubbles provide pressure release surfaces converting the pressure from highly positive to negative. In this study, the second-harmonic was superimposed onto the fundamental acoustic pressure to emphasize either peak positive or negative pressure. The peak negative and positive pressure emphasized waves were focused on a surface of an aluminum block. Cavitation bubbles induced near the block were observed with a high-speed camera by backlight and the size of the cavitation generation region was measured from the high-speed images. The negative pressure emphasized waves showed an advantage in cavitation inception over the positive pressure emphasized waves. In the sequence of the negative pressure emphasized waves immediately followed by the positive pressure emphasized waves, cavitation bubbles were generated on the block by the former waves and the cavitation region were expanded toward the transducer in the latter waves with high reproducibility. The sequence demonstrated its potential usefulness in enhancing the effects of therapeutic ultrasound at a high acoustic intensity.

  3. A Road Map for the Generation of a Near-Infrared Guide Star Catalog for Thirty Meter Telescope Observations

    NASA Astrophysics Data System (ADS)

    Subramanian, Smitha; Subramaniam, Annapurni; Sivarani, T.; Simard, Luc; Anupama, G. C.; Gillies, Kim; Ramaprakash, A. N.; Reddy, B. Eswar

    2016-09-01

    The near-infrared instruments in the upcoming Thirty Meter Telescope (TMT) will be assisted by a multi conjugate Adaptive Optics (AO) system. For the efficient operation of the AO system, during observations, a near-infrared guide star catalog which goes as faint as 22 mag in JVega band is essential and such a catalog does not exist. A methodology, based on stellar atmospheric models, to compute the expected near-infrared magnitudes of stellar sources from their optical magnitudes is developed. The method is applied and validated in JHKs bands for a magnitude range of JVega 16-22 mag. The methodology is also applied and validated using the reference catalog of PAN STARRS. We verified that the properties of the final PAN STARRS optical catalog will satisfy the requirements of TMT IRGSC and will be one of the potential sources for the generation of the final catalog. In a broader context, this methodology is applicable for the generation of a guide star catalog for any existing/upcoming near-infrared telescopes.

  4. Addressing the Achilles' Heel in the HIV Care Continuum for the Success of a Test-and-Treat Strategy to Achieve an AIDS-Free Generation

    PubMed Central

    Nachega, Jean B.; Uthman, Olalekan A.; del Rio, Carlos; Mugavero, Michael J.; Rees, Helen; Mills, Edward J.

    2014-01-01

    Mathematical models and recent data from ecological, observational, and experimental studies show that antiretroviral therapy (ART) is effective for both treatment and prevention of HIV, validating the treatment as prevention (TasP) approach. Data from a variety of settings, including resource-rich and -limited sites, show that patient attrition occurs at each stage of the human immunodeficiency virus (HIV) treatment cascade, starting with the percent unaware of their HIV infection in a population and linkage to care after diagnosis, assessment of ART readiness, receipt of ART, and finally long-term virologic suppression. Therefore, in order to implement TasP, we must first define practical and effective linkage to care, acceptability of treatment, and adherence and retention monitoring strategies, as well as the cost-effectiveness of such strategies. Ending this pandemic will require the combination of political will, resources, and novel effective interventions that are not only feasible and cost effective but also likely to be used in combination across successive steps on the HIV treatment cascade. PMID:24926028

  5. Succession planning.

    PubMed

    Catanzaro, Thomas E

    2006-03-01

    This article provides the reader with an appreciation of the diverse elements that go into a buy-sell, affiliation, or merger situation for veterinary practices. In the changing market place of American veterinary medicine, old paradigms no longer hold comfort. The generational differences are briefly explored herein as well as the new economic realities. A few examples are offered to illustrate just how much variability exists in the current business of veterinary medicine and the subsequent practice transitions needed to enhance value. Functioning models are explored, as well as affiliation and merger options. Practice valuation is discussed in general terms, referencing the cutting-edge factors. The six-point summary provides almost all practices a solid operational base for daily operations and succession planning.

  6. Generation and use of observational data patterns in the evaluation of data quality for AmeriFlux and FLUXNET

    NASA Astrophysics Data System (ADS)

    Pastorello, G.; Agarwal, D.; Poindexter, C.; Papale, D.; Trotta, C.; Ribeca, A.; Canfora, E.; Faybishenko, B.; Gunter, D.; Chu, H.

    2015-12-01

    The fluxes-measuring sites that are part of AmeriFlux are operated and maintained in a fairly independent fashion, both in terms of scientific goals and operational practices. This is also the case for most sites from other networks in FLUXNET. This independence leads to a degree of heterogeneity in the data sets collected at the sites, which is also reflected in data quality levels. The generation of derived data products and data synthesis efforts, two of the main goals of these networks, are directly affected by the heterogeneity in data quality. In a collaborative effort between AmeriFlux and ICOS, a series of quality checks are being conducted for the data sets before any network-level data processing and product generation take place. From these checks, a set of common data issues were identified, and are being cataloged and classified into data quality patterns. These patterns are now being used as a basis for implementing automation for certain data quality checks, speeding up the process of applying the checks and evaluating the data. Currently, most data checks are performed individually in each data set, requiring visual inspection and inputs from a data curator. This manual process makes it difficult to scale the quality checks, creating a bottleneck for the data processing. One goal of the automated checks is to free up time of data curators so they can focus on new or less common issues. As new issues are identified, they can also be cataloged and classified, extending the coverage of existing patterns or potentially generating new patterns, helping both improve existing automated checks and create new ones. This approach is helping make data quality evaluation faster, more systematic, and reproducible. Furthermore, these patterns are also helping with documenting common causes and solutions for data problems. This can help tower teams with diagnosing problems in data collection and processing, and also in correcting historical data sets. In this

  7. Preliminary observations of voluminous ice-rich and water-rich lahars generated during the 2009 eruption of Redoubt, Alaska

    USGS Publications Warehouse

    Waythomas, Christopher F.; Pierson, Thomas C.; Major, Jon J.; Scott, William E.

    2012-01-01

    juvenile andesite. We infer that the lahars generated on March 23 were initiated by a rapid succession of vent-clearing explosions that blasted through about 50–100 m of crater-filling glacier ice and snow, producing a voluminous release of meltwater from the Drift glacier. The resulting flood eroded and entrained snow, fragments of glacier and river ice, and liquid water along its flow path. Small-volume pyroclastic flows, possibly associated with destruction of a small dome or minor eruption-column collapses, may have contributed additional meltwater to the lahar. Meltwater generated by subglacial hydrothermal activity and stored beneath the Drift glacier may have been ejected or released rapidly as well. The April 4 lahar was initiated when hot dome-collapse pyroclastic flows entrained and swiftly melted snow and ice, and incorporated additional rock debris from the Drift glacier. The peak discharge of the April 4 lahar was in the range of 60,000–160,000 m3s-1. For comparison, the largest lahar of the 1989–90 eruption had a peak discharge of about 80,000 m3s-1. Lahars generated by the 2009 eruption led to significant channel aggradation in the lower Drift River valley and caused extensive inundation at an oil storage and transfer facility located there. The April 4, 2009, lahar was 6–30 times larger than the largest meteorological floods known or estimated in the Drift River drainage.

  8. Ten years of OMI observations: scientific highlights and impacts on the new generation of UV/VIS satellite instrumentation

    NASA Astrophysics Data System (ADS)

    Levelt, Pieternel; Veefkind, Pepijn; Bhartia, Pawan; Joiner, Joanna; Tamminen, Johanna; OMI Science Team

    2014-05-01

    On July 15, 2004 Ozone Monitoring Instrument (OMI) was successfully launched from the Vandenberg military air force basis in California, USA, on NASA's EOS-Aura spacecraft. OMI is the first of a new generation of UV/VIS nadir solar backscatter imaging spectrometers, which provides nearly global coverage in one day with an unprecedented spatial resolution of 13 x 24 km2. OMI measures solar irradiance and Earth radiances in the wavelength range of 270 to 500 nm with a spectral resolution of about 0.5 nm. OMI is designed and built by the Netherlands and Finland and is also a third party mission of ESA. The major step that was made in the OMI instrument compared to its predecessors is the use of 2-dimensional detector arrays (CCDs) in a highly innovative small optical design. These innovations enable the combination of a high spatial resolution and a good spectral resolution with daily global coverage. OMI measures a range of trace gases (O3, NO2, SO2, HCHO, BrO, OClO, H2O), clouds and aerosols. Albeit OMI is already 5 years over its design lifetime, the instrument is still fully operational. The successor of OMI is TROPOMI (TROPOspheric Monitoring Instrument) on the Copernicus Sentinel-5 precursor mission, planned for launch in 2015. OMI's unique capabilities rely in measuring tropospheric trace gases with a small footprint and daily global coverage. The unprecedented spatial resolution of the instrument revealed for the first time tropospheric pollution maps on a daily basis with urban scale resolution leading to improved air quality forecasts. The OMI measurements also improve our understanding of air quality and the interaction between air quality and climate change by combining measurements of air pollutants and aerosols. In recent years the data are also used for obtaining high-resolution global emission maps using inverse modelling or related techniques, challenging the bottom-up inventories based emission maps. In addition to scientific research, OMI also

  9. Comparison Between Tsunami Signals Generated by Different Source Models and the Observed Data of the Illapel 2015 Earthquake

    NASA Astrophysics Data System (ADS)

    Calisto, Ignacia; Miller, Matthew; Constanzo, Iván

    2016-04-01

    A major interplate earthquake occurred on September 16th, 2015, near Illapel, central Chile. This event generated a tsunami of moderate height, however, one which caused significant near field damage. In this study, we model the tsunami produced by some rapid and preliminary fault models with the potential to be calculated within tens of minutes of the event origin time. We simulate tsunami signals from two different heterogeneous slip models, a homogeneous source based on parameters from the global CMT Project, and furthermore we used plate coupling data from GPS observations to construct a heterogeneous fault based on a priori knowledge of the subduction zone. We compare the simulated signals with the observed tsunami at tide gauges located along the Chilean coast and at offshore DART buoys. For this event, concerning rapid response, the homogeneous source and coupling model represent the tsunami at least as well as the heterogeneous sources. We suggest that the initial heterogeneous fault models could be better constrained with continuous GPS measurements in the rupture area, and additionally DART records directly in front of the rupture area, to improve the tsunami simulation based on quickly calculated models for near coastal areas. Additionally, in terms of tsunami modeling, the source estimated from prior plate coupling information in this case is representative of the event that later occurs; placing further importance on the need to monitor subduction zones with GPS.

  10. Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

    PubMed Central

    Blodgett, David M.; Nowosielska, Anetta; Afik, Shaked; Pechhold, Susanne; Cura, Anthony J.; Kennedy, Norman J.; Kim, Soyoung; Kucukural, Alper; Davis, Roger J.; Kent, Sally C.; Greiner, Dale L.; Garber, Manuel G.; diIorio, Philip

    2015-01-01

    Understanding distinct gene expression patterns of normal adult and developing fetal human pancreatic α- and β-cells is crucial for developing stem cell therapies, islet regeneration strategies, and therapies designed to increase β-cell function in patients with diabetes (type 1 or 2). Toward that end, we have developed methods to highly purify α-, β-, and δ-cells from human fetal and adult pancreata by intracellular staining for the cell-specific hormone content, sorting the subpopulations by flow cytometry, and, using next-generation RNA sequencing, we report the detailed transcriptomes of fetal and adult α- and β-cells. We observed that human islet composition was not influenced by age, sex, or BMI, and transcripts for inflammatory gene products were noted in fetal β-cells. In addition, within highly purified adult glucagon-expressing α-cells, we observed surprisingly high insulin mRNA expression, but not insulin protein expression. This transcriptome analysis from highly purified islet α- and β-cell subsets from fetal and adult pancreata offers clear implications for strategies that seek to increase insulin expression in type 1 and type 2 diabetes. PMID:25931473

  11. An Algorithm to Generate Deep-Layer Temperatures from Microwave Satellite Observations for the Purpose of Monitoring Climate Change. Revised

    NASA Technical Reports Server (NTRS)

    Goldberg, Mitchell D.; Fleming, Henry E.

    1994-01-01

    An algorithm for generating deep-layer mean temperatures from satellite-observed microwave observations is presented. Unlike traditional temperature retrieval methods, this algorithm does not require a first guess temperature of the ambient atmosphere. By eliminating the first guess a potentially systematic source of error has been removed. The algorithm is expected to yield long-term records that are suitable for detecting small changes in climate. The atmospheric contribution to the deep-layer mean temperature is given by the averaging kernel. The algorithm computes the coefficients that will best approximate a desired averaging kernel from a linear combination of the satellite radiometer's weighting functions. The coefficients are then applied to the measurements to yield the deep-layer mean temperature. Three constraints were used in deriving the algorithm: (1) the sum of the coefficients must be one, (2) the noise of the product is minimized, and (3) the shape of the approximated averaging kernel is well-behaved. Note that a trade-off between constraints 2 and 3 is unavoidable. The algorithm can also be used to combine measurements from a future sensor (i.e., the 20-channel Advanced Microwave Sounding Unit (AMSU)) to yield the same averaging kernel as that based on an earlier sensor (i.e., the 4-channel Microwave Sounding Unit (MSU)). This will allow a time series of deep-layer mean temperatures based on MSU measurements to be continued with AMSU measurements. The AMSU is expected to replace the MSU in 1996.

  12. Observation of the atomic structure of ß'-SiAlON using three generations of high resolution electron microscopes

    NASA Astrophysics Data System (ADS)

    Thorel, A.; Ciston, J.; Bartel, T.; Song, C.-Y.; Dahmen, U.

    2013-04-01

    The structure of a ß‧-SiAlON (Si5.6Al0.4O0.4N7.6) has been observed using three generations of unique high resolution microscopes spanning over three decades of development in instrumentation - the Atomic Resolution Microscope (ARM), the One Angstrom Microscope (OAM) and the Transmission Electron Aberration-corrected Microscope (TEAM). The information limits of these microscopes are 0.16, 0.08 and 0.05 nm respectively. Observations along ⟨0 0 0 1⟩ at Scherzer defocus for each microscope demonstrate a drastic increase in structural information. Images taken on TEAM show clearly resolved atomic columns whereas the ARM images were only indirectly related to the structure. Nevertheless, the loss of the six-fold symmetry associated with the O/N and Al/Si substitutions was already visible on images taken on the ARM, and an associated ∼25 pm displacement of the O substituting for N in some of the 2c Wyckoff positions of the SiN unit cell was measured on exit wave reconstructions obtained from through focal series on the OAM. This paper illustrates how progress in instrumentation impacts our analysis and understanding of materials.

  13. Generation of global VTEC maps from low latency GNSS observations based on B-spline modelling and Kalman filtering

    NASA Astrophysics Data System (ADS)

    Erdogan, Eren; Dettmering, Denise; Limberger, Marco; Schmidt, Michael; Seitz, Florian; Börger, Klaus; Brandert, Sylvia; Görres, Barbara; Kersten, Wilhelm F.; Bothmer, Volker; Hinrichs, Johannes; Venzmer, Malte

    2015-04-01

    In May 2014 DGFI-TUM (the former DGFI) and the German Space Situational Awareness Centre (GSSAC) started to develop an OPerational Tool for Ionospheric Mapping And Prediction (OPTIMAP); since November 2014 the Institute of Astrophysics at the University of Göttingen (IAG) joined the group as the third partner. This project aims on the computation and prediction of maps of the vertical total electron content (VTEC) and the electron density distribution of the ionosphere on a global scale from both various space-geodetic observation techniques such as GNSS and satellite altimetry as well as Sun observations. In this contribution we present first results, i.e. a near-real time processing framework for generating VTEC maps by assimilating GNSS (GPS, GLONASS) based ionospheric data into a two-dimensional global B-spline approach. To be more specific, the spatial variations of VTEC are modelled by trigonometric B-spline functions in longitude and by endpoint-interpolating polynomial B-spline functions in latitude, respectively. Since B-spline functions are compactly supported and highly localizing our approach can handle large data gaps appropriately and, thus, provides a better approximation of data with heterogeneous density and quality compared to the commonly used spherical harmonics. The presented method models temporal variations of VTEC inside a Kalman filter. The unknown parameters of the filter state vector are composed of the B-spline coefficients as well as the satellite and receiver DCBs. To approximate the temporal variation of these state vector components as part of the filter the dynamical model has to be set up. The current implementation of the filter allows to select between a random walk process, a Gauss-Markov process and a dynamic process driven by an empirical ionosphere model, e.g. the International Reference Ionosphere (IRI). For running the model ionospheric input data is acquired from terrestrial GNSS networks through online archive systems

  14. Acoustic waves generated from seismic surface waves: propagation properties determined from Doppler sounding observations and normal-mode modelling

    NASA Astrophysics Data System (ADS)

    Artru, Juliette; Farges, Thomas; Lognonné, Philippe

    2004-09-01

    Since 1960, experiments have shown that perturbations of the ionosphere can occur after earthquakes, by way of dynamic coupling between seismic surface waves and the atmosphere. The atmospheric wave is amplified exponentially while propagating upwards due to the decrease of density, and interaction with the ionospheric plasma leads to clearly identified signals on both ground-based or satellite ionospheric measurements. In 1999 and 2000, after an upgrade of the HF Doppler sounder, the Commisariat à l'Énergie Atomique systematically recorded these effects in the ionosphere with the Francourville (France) network, by measuring vertical oscillations of ionospheric layers with the Doppler technique. Normal-mode theory extended to a solid Earth with an atmosphere allows successful modelling of such signals, even if this 1-D approach is probably too crude, especially in the solid Earth, where 20 s surface waves see large lateral variations in the crust. The combination of observations and simulations provides a new tool to determine acoustic gravity wave propagation characteristics from the ground to ionospheric height. Observed velocity and amplification of the atmospheric waves show good agreement from the ground up to moderate sounding altitudes (140-150 km); however, at higher altitudes the propagation speed is found to be much smaller than predicted and attenuation is underestimated. This shows that the standard formalism of acoustic gravity waves in the atmosphere cannot efficiently describe propagation in the ionized atmosphere. Further work is needed to characterize the propagation of acoustic waves in this altitude range: we believe that seismic waves can provide a well-constrained source for such study.

  15. Experimental observations of the spatial structure of wave-like disturbances generated in midlatitude ionosphere by high power radio waves

    NASA Astrophysics Data System (ADS)

    Kunitsyn, V.; Andreeva, E.; Padokhin, A. M.; Nazarenko, M.; Frolov, V.; Komrakov, G.; Bolotin, I.

    2012-12-01

    We present the results of the experiments carried out in 2009-2012 on the Sura heating facility (Radio Physical Research Institute, N. Novgorod, Russia) on modification of the midlatitude ionosphere by powerful HF radiowaves. The experiments were conducted using O-mode radiowaves at frequencies lower than critical frequency of the ionospheric F2 layer both in daytime and nighttime ionosphere. Various schemes of the radiation of the heating wave were used including square wave modulation of the effective radiated power (ERP) at various frequencies and power stepping. Radio transmissions of the low- (Parus/Tsikada) and high-orbital (GPS/GLONASS) navigational satellites received at the mobile network of receiving sites were used for the remote sensing of the heated area of the ionosphere. The variations in the slant total electron content (TEC), which are proportional to the reduced phase of navigational signals, were studied for the satellite passes for which ionospheric penetration points crossed the disturbed area during HF heating. The variations in TEC caused by HF heating are identified in a number of examples. It is shown that the GNSS TEC spectra contain frequency components corresponding to the modulation periods of the ERP of the heating wave. The manifestations of the heating-induced variations in TEC are most prominent in the area of magnetic zenith of the pumping wave. Different behavior of TEC variations was observed during nighttime and daytime heating experiments. In daytime conditions the pump wave switched ON causes the increase of TEC while in the nighttime it causes a decrease in TEC. This can be explained by the different contribution of the processes responsible for the increase and decrease of TEC in daytime in nighttime conditions. In this work we also present the first time radiotomographic reconstructions of the spatial structure of the wave-like disturbances, generated in the ionosphere by high-power radio waves radiated by the Sura heater

  16. The fate of cetacean carcasses in the deep sea: observations on consumption rates and succession of scavenging species in the abyssal north-east Atlantic Ocean

    PubMed Central

    Jones, E. G.; Collins, M. A.; Bagley, P. M.; Addison, S.; Priede, I. G.

    1998-01-01

    The fate of cetacean carcasses in the deep sea was investigated using autonomous deep-sea lander vehicles incorporating time-lapse camera systems, fish and amphipod traps. Three lander deployments placed cetacean carcasses at depths of 4000 to 4800 m in the north-east Atlantic for periods of 36 h, 152 h and 276 h before being recovered. The photographic sequences revealed that carcasses were rapidly consumed by fish and invertebrate scavengers with removal rates ranging from 0.05 to 0.4 kg h-1. In the longest experiment the carcass was skeletonized within five days. In each deployment, approximately an hour after emplacement, the grenadier Coryphaenoides (Nematonurus) armatus and large numbers of lysianassid amphipods had arrived at the food-fall. The initially high numbers of grenadiers declined once the majority of the bait had been consumed and a variety of other fish and invertebrates were then observed, some taking up residence at the site. None of the fish species appeared to consume the carcass directly, but preyed upon amphipods instead. Funnel traps recovered with the carcass indicated a succession in the species composition of amphipods, with the specialist necrophages such as Paralicella spp. being replaced by more generalist feeders of the Orchomene species complex.

  17. Success rate of IR midazolam sedation in combination with C-CLAD in pediatric dental patients—a prospective observational study

    PubMed Central

    Baniel, Anat

    2014-01-01

    Objective. To evaluate the success rate of intra-rectal (IR) midazolam in combination with nitrous oxide/oxygen (N2O) sedation in young uncooperative dental patients when the local anesthesia is delivered by a computerized controlled local anesthetic delivery (C-CLAD). Study Design. This observational study consisted of 219 uncooperative children (age: 4.3 ± 1.69 y) who received IR midazolam (0.4 mg/kg) and N2O to complete their dental treatment. Measured variables included: child’s pain disruptive behavior during delivery of anesthesia by C-CLAD (CHEOP Scale), child behavior during treatment (Houpt scale), dental procedure performed, and side effects that appeared during treatment. Results. There was a high level of cooperation (mean score: 6.69 ± 2.1) during administration of local anesthesia. Good-to-excellent behavior was shown by 87% of the children during treatment. Planned treatment was completed by 184 (92%) patients. No statistically significant changes were noticed in the oxygen saturation levels before and after treatment. Children with side effects included 3 (1.3%) with nistagmus, 5 (2.3%) with diplopia, and 18 (8.2%) with hiccups. Three consecutive sedations decreased the overall behavior score by 5.7% compared to the first appointment (p < .05). Conclusions. IR midazolam-N2O sedation in combination with C-CLAD is very effective for delivery of dental treatment to young uncooperative children. PMID:24688838

  18. Success rate of IR midazolam sedation in combination with C-CLAD in pediatric dental patients-a prospective observational study.

    PubMed

    Ashkenazi, Malka; Baniel, Anat

    2014-01-01

    Objective. To evaluate the success rate of intra-rectal (IR) midazolam in combination with nitrous oxide/oxygen (N2O) sedation in young uncooperative dental patients when the local anesthesia is delivered by a computerized controlled local anesthetic delivery (C-CLAD). Study Design. This observational study consisted of 219 uncooperative children (age: 4.3 ± 1.69 y) who received IR midazolam (0.4 mg/kg) and N2O to complete their dental treatment. Measured variables included: child's pain disruptive behavior during delivery of anesthesia by C-CLAD (CHEOP Scale), child behavior during treatment (Houpt scale), dental procedure performed, and side effects that appeared during treatment. Results. There was a high level of cooperation (mean score: 6.69 ± 2.1) during administration of local anesthesia. Good-to-excellent behavior was shown by 87% of the children during treatment. Planned treatment was completed by 184 (92%) patients. No statistically significant changes were noticed in the oxygen saturation levels before and after treatment. Children with side effects included 3 (1.3%) with nistagmus, 5 (2.3%) with diplopia, and 18 (8.2%) with hiccups. Three consecutive sedations decreased the overall behavior score by 5.7% compared to the first appointment (p < .05). Conclusions. IR midazolam-N2O sedation in combination with C-CLAD is very effective for delivery of dental treatment to young uncooperative children.

  19. Storm generated large scale TIDs (LSTIDs): local, regional and global observations during solar cycles 23-24

    NASA Astrophysics Data System (ADS)

    Katamzi, Zama; Bosco Habarulema, John

    2017-04-01

    Large scale traveling ionospheric disturbances (LSTIDs) are a key dynamic ionospheric process that transports energy and momentum vertically and horizontally during storms. These disturbances are observed as electron density irregularities in total electron content and other ionospheric parameters. This study reports on various explorations of LSTIDs characteristics, in particular horizontal and vertical propagation, during some major/severe storms of solar cycles 23-24. We have employed GNSS TEC to estimate horizontal propagation and radio occultation data from COSMIC/FORMOSAT-3 and SWARM satellites to estimate vertical motion. The work presented here reveals the evolution of the characterisation efficiency from using sparsely populated stations, resulting in limited spatial resolution through rudimentary analysis to more densely populated GNSS network leading to more accurate temporal and spatial determinations. For example, early observations of LSTIDs largely revealed unidirectional propagation whereas later studies have showed that one storm can induce multi-directional propagation, e.g. Halloween 2003 storm induced equatorward LSTIDs on a local scale whereas the 9 March 2012 storm induced simultaneous equatorward and poleward LSTIDs on a global scale. This later study, i.e. 9 March 2012 storm, revealed for the first time that ionospheric electrodynamics, specifically variations in ExB drift, is also an efficient generator of LSTIDs. Results from these studies also revealed constructive and destructive interference pattern of storm induced LSTIDs. Constellations of LEO satellites such as COSMIC/FORMOSAT-3 and SWARM have given sufficient spatial and temporal resolution to study vertical propagation of LSTIDs in addition to the meridional propagation given by GNSS TEC; the former (i.e. vertical velocities) were found to fall below 100 m/s.

  20. Observation of propagating femtosecond light pulse train generated by an integrated array illuminator as a spatially and temporally continuous motion picture.

    PubMed

    Yamagiwa, Masatomo; Komatsu, Aya; Awatsuji, Yasuhiro; Kubota, Toshihiro

    2005-05-02

    We observed a propagating femtosecond light pulse train generated by an integrated array illuminator as a spatially and temporally continuous motion picture. To observe the light pulse train propagating in air, light-in-flight holography is applied. The integrated array illuminator is an optical device for generating an ultrashort light pulse train from a single ultrashort pulse. The experimentally obtained pulse width and pulse interval were 130 fs and 19.7 ps, respectively. A back-propagating femtosecond light pulse train, which is the -2 order diffracted light pulse from the array illuminator and which is difficult to observe using conventional methods, was observed.

  1. Direct Observation of Landau Level Resonance and Mass Generation in Dirac Semimetal Cd3As2 Thin Films.

    PubMed

    Yuan, Xiang; Cheng, Peihong; Zhang, Longqiang; Zhang, Cheng; Wang, Junyong; Liu, Yanwen; Sun, Qingqing; Zhou, Peng; Zhang, David Wei; Hu, Zhigao; Wan, Xiangang; Yan, Hugen; Li, Zhiqiang; Xiu, Faxian

    2017-04-12

    Three-dimensional topological Dirac semimetals have hitherto stimulated unprecedented research interests as a new class of quantum materials. Breaking certain types of symmetries has been proposed to enable the manipulation of Dirac fermions, and that was soon realized by external modulations such as magnetic fields. However, an intrinsic manipulation of Dirac states, which is more efficient and desirable, remains a significant challenge. Here, we report a systematic study of quasi-particle dynamics and band evolution in Cd3As2 thin films with controlled chromium (Cr) doping by both magneto-infrared spectroscopy and electrical transport. We observe the √B relation of inter-Landau-level resonance in Cd3As2, an important signature of ultrarelativistic massless state inaccessible in previous optical experiments. A crossover from quantum to quasi-classical behavior makes it possible to directly probe the mass of Dirac fermions. Importantly, Cr doping allows for a Dirac mass acquisition and topological phase transition enabling a desired dynamic control of Dirac fermions. Corroborating with the density-functional theory calculations, we show that the mass generation can be explained by the explicit C4 rotation symmetry breaking and the resultant Dirac gap engineering through Cr substitution for Cd atoms. The manipulation of the system symmetry and Dirac mass in Cd3As2 thin films provides a tuning knob to explore the exotic states stemming from the parent phase of Dirac semimetals.

  2. Observations of the coupling efficiency of VLF lightning-generated whistlers into the low-latitude plasmasphere

    NASA Astrophysics Data System (ADS)

    Jacobson, A. R.; Holzworth, R. H., II; Pfaff, R. F., Jr.; Heelis, R. A.

    2014-12-01

    The C/NOFS satellite [de La Beaujardiere, 2004] has provided a vast archive of multi-sensor data on the low-latitude ionosphere/plasmasphere since 2008. As part of the project, the VEFI payload [Pfaff et al., 2010] has recorded the 3-D electric field from DC through 16 kHz with high fidelity. The relative calibrations track between the three E-field antennas with sufficient accuracy and stability to allow retrieval of the wave polarization for a wide range of lightning-generated whistler waves [Jacobson et al., 2014]. The wave polarization in turn allows retrieval of the wavevector (within a sign ambiguity), which in turn allows an inverse-raytrace of the whistler raypath from the satellite to the ionospheric entry point. We will compare the raytrace predictions with ground-truth from the WWLLN global lightning-monitoring system [Lay et al., 2004; Rodger et al., 2005; Rodger et al., 2004]. In addition to providing location and time of lightning strokes, WWLLN provides an estimate of the radiated radio energy in the whistler passband [Hutchins et al., 2012]. Finally, the CINDI payload [Heelis et al., 2009] on C/NOFS provides ion composition at the satellite, permitting the index of refraction to be inferred. We will compare these estimates to the Poynting fluence density observed by VEFI, thereby providing a direct test of the coupling of lightning radio energy into plasmaspheric whistlers.

  3. Intraoperative observation of changes in cochlear nerve action potentials during exposure to electromagnetic fields generated by mobile phones.

    PubMed

    Colletti, Vittorio; Mandalà, Marco; Manganotti, Paolo; Ramat, Stefano; Sacchetto, Luca; Colletti, Liliana

    2011-07-01

    The rapid spread of devices generating electromagnetic fields (EMF) has raised concerns as to the possible effects of this technology on humans. The auditory system is the neural organ most frequently and directly exposed to electromagnetic activity owing to the daily use of mobile phones. In recent publications, a possible correlation between mobile phone usage and central nervous system tumours has been detected. Very recently a deterioration in otoacoustic emissions and in the auditory middle latency responses after intensive and long-term magnetic field exposure in humans has been demonstrated. To determine with objective observations if exposure to mobile phone EMF affects acoustically evoked cochlear nerve compound action potentials, seven patients suffering from Ménière's disease and undergoing retrosigmoid vestibular neurectomy were exposed to the effects of mobile phone placed over the craniotomy for 5 min. All patients showed a substantial decrease in amplitude and a significant increase in latency of cochlear nerve compound action potentials during the 5 min of exposure to EMF. These changes lasted for a period of around 5 min after exposure. The possibility that EMF can produce relatively long-lasting effects on cochlear nerve conduction is discussed and analysed in light of contrasting previous literature obtained under non-surgical conditions. Limitations of this novel approach, including the effects of the anaesthetics, craniotomy and surgical procedure, are presented in detail.

  4. The Observation of SAR, Optical and Altimeter Data to Study the Generation of Internal Wave in Tsushima Strait

    NASA Astrophysics Data System (ADS)

    Arvelyna, Y.; Oshima, M.

    2006-07-01

    This study proposes D iscr eet Mey er wavelet tr ansform and spectr al reflectan ce analysis for internal w ave detection in ERS1/2 and ASTER imag es data over the Tsushima Strait, Jap an, during 1993-2004 period. The wavelet tr ansform of imag e w as successfully der ived the intern al wav e f eature with h igher w avelet coeff icien t than sea surf ace, i.e. between 2-4.59 times, on horizon tal and vertical d etail coefficient at level 2-5, incr eased the detection probability over 80%. The intern al w ave is modeled using Co mbined Korteweg the Vries (combKdV) model. Non linier speed of in ternal wave is calculated about 85 cm-1. Th e altimetry data products from Topex/Poseidon and Jason-1 data are used to predict th e internal wav e gener ation. Th e observation results show th e propagation of in ternal w aves wer e varied between N W-SW at eastern channel and N-SW at western channel of Tsush ima Strait, p arallel to the direction of the geostrophic curren t. A t NE coast off Tsushima Island, the direction is on S/SE dir ection. I t is suggested th at th e internal wav es w ere sourced from south co ast off Tsush ima Island and south coast off the Japan Sea. They w ere possib ly tid ally gen erated and formed due to bathymetr ic change.

  5. A Generation of Challenge: Pathways to Success for Urban Youth. A Policy Study of the Levitan Youth Policy Network. Policy Issues Monograph 97-03.

    ERIC Educational Resources Information Center

    Sum, Andrew; Mangum, Stephen; deJesus, Edward; Walker, Gary; Gruber, David; Pines, Marion; Spring, William

    This report refers to a generation under challenge, meaning the 18-to-24-year-olds who have recently come of age in the United States. A significant part of this generation has fallen victim to a neglected past and may be overwhelmed by its future. The report argues for an integrated and comprehensive service delivery system that can make a…

  6. DisasterHub: A mobile application for enabling crowd generated data fusion in Earth Observation disaster management services

    NASA Astrophysics Data System (ADS)

    Tsironis, Vassilis; Herekakis, Themistocles; Tsouni, Alexia; Kontoes, Charalampos Haris

    2016-04-01

    The rapid changes in climate over the last decades, together with the explosion of human population, have shaped the context for a fragile biosphere, prone to natural and manmade disasters that result in massive flows of environmental immigrants and great disturbances of ecosystems. The magnitude of the latest great disasters have shown evidence for high quality Earth Observation (EO) services as it regards disaster risk reduction and emergency support (DRR & EMS). The EO community runs ambitious initiatives in order to generate services with direct impact in the biosphere, and intends to stimulate the wider participation of citizens, enabling the Openness effect through the Open Innovation paradigm. This by its turn results in the tremendous growth of open source software technologies associated with web, social media, mobile and Crowdsourcing. The Institute for Astronomy, Astrophysics, Space Applications and Remote Sensing of National Observatory of Athens has developed, in the framework of the BEYOND Centre of Excellence for EO-based monitoring of Natural Disasters (http://www.beyond-eocenter.eu), a rich ecosystem of Copernicus compliant services addressing diverse hazardous phenomena caused from climate and weather extremes (fires, floods, windstorms, heat waves), atmospheric disturbances (smoke, dust, ozone, UV), and geo-hazards (earthquakes, landslides, volcanoes). Several services are delivered in near-real time to the public and the institutional authorities at national and regional level in southeastern Europe. Specific ones have been recognized worldwide for their innovation and operational aspects (e.g. FIREHUB was awarded the first prize as Best Service Challenge in the Copernicus Masters Competition, 2014). However, a communication gap still exists between the BEYOND ecosystem and those directly concerned by the natural disasters, the citizens and emergency response managers. This disruption of information flow between interested parties is addressed

  7. Quantifying the VNIR Effects of Nanophase Iron Generated through the Space Weathering of Silicates: Reconciling Modeled Data with Laboratory Observations

    NASA Astrophysics Data System (ADS)

    Legett, C., IV; Glotch, T. D.; Lucey, P. G.

    2015-12-01

    Space weathering is a diverse set of processes that occur on the surfaces of airless bodies due to exposure to the space environment. One of the effects of space weathering is the generation of nanophase iron particles in glassy rims on mineral grains due to sputtering of iron-bearing minerals. These particles have a size-dependent effect on visible and near infrared (VNIR) reflectance spectra with smaller diameter particles (< 50 nm) causing both reddening and darkening of the spectra with respect to unweathered material (Britt-Pieters particle behavior), while larger particles (> 300 nm) darken without reddening. Between these two sizes, a gradual shift between these two behaviors occurs. In this work, we present results from the Multiple Sphere T-Matrix (MSTM) scattering model in combination with Hapke theory to explore the particle size and iron content parameter spaces with respect to VNIR (700-1700 nm) spectral slope. Previous work has shown that the MSTM-Hapke hybrid model offers improvements over Mie-Hapke models. Virtual particles are constructed out of an arbitrary number of spheres, and each sphere is assigned a refractive index and extinction coefficient for each wavelength of interest. The model then directly solves Maxwell's Equations at every wave-particle interface to predict the scattering, extinction and absorption efficiencies. These are then put into a simplified Hapke bidirectional reflectance model that yields a predicted reflectance. Preliminary results show an area of maximum slopes for iron particle diameters < 80 nm and iron concentrations of ~1-10wt% in an amorphous silica matrix. Further model runs are planned to better refine the extent of this region. Companion laboratory work using mixtures of powdered aerogel and nanophase iron particles provides a point of comparison to modeling efforts. The effects on reflectance and emissivity values due to particle size in a nearly ideal scatterer (aerogel) are also observed with comparisons to

  8. Is There Such a Thing as Too Much of a Good Thing when It Comes to Education? Reexamining First Generation Student Success

    ERIC Educational Resources Information Center

    D'Allegro, Mary Lou; Kerns, Stefanie

    2011-01-01

    Data mining and statistical analyses at a less selective institution reveal that the relationships between parents' educational level and some first year success indicators are not linear. Specifically, students who report that either parent or guardian(s) have an educational level beyond a baccalaureate degree or do not report parent education…

  9. Lateral Pharyngeal Wall Tension After Maxillomandibular Advancement for Obstructive Sleep Apnea Is a Marker for Surgical Success: Observations From Drug-Induced Sleep Endoscopy.

    PubMed

    Liu, Stanley Yung-Chuan; Huon, Leh-Kiong; Powell, Nelson B; Riley, Robert; Cho, Hyunje Grace; Torre, Carlos; Capasso, Robson

    2015-08-01

    The efficacy of maxillomandibular advancement (MMA) for obstructive sleep apnea (OSA) with anatomic airway changes has previously been studied using static imaging and endoscopy in awake subjects. The aim of the present study was to use drug-induced sleep endoscopy (DISE) to evaluate the dynamic upper airway changes in sleeping subjects before and after MMA and their association with the surgical outcome. This was a retrospective cohort study of subjects with OSA who had undergone MMA at the Stanford University Sleep Surgery Division from July 2013 to July 2014. The subjects were included if perioperative polysomnography and DISE had been performed. The predictor variable was the perioperative DISE velum-oropharynx-tongue-epiglottis score. The outcome variables were the apnea-hypopnea index (AHI), oxygen-desaturation index (ODI), and Epworth Sleepiness Scale (ESS). A subgroup analysis was performed for the subjects who had undergone primary and secondary MMA. The statistical analyses included Cronbach's α coefficient, the McNemar test, and the independent Student t test. The P value was set at <.01. A total of 16 subjects (15 males, 1 female) were included in the present study, with an average age of 47 ± 10.9 years and body mass index of 29.4 ± 5.1 kg/m(2). Significant post-MMA decreases were found in the AHI (from 59.8 ± 25.6 to 9.3 ± 7.1 events/hr) and ODI (from 45 ± 29.7 to 5.7 ± 4.1 events/hr; P < .001). Greater improvement in the AHI occurred in the primary MMA group (P = .022). The post-MMA change in airway collapse was most significant at the lateral pharyngeal wall (P = .001). The subjects with the most improvement in lateral pharyngeal wall collapsibility demonstrated the largest changes in the AHI (from 60.0 ± 25.6 events/hr to 7.5 ± 3.4 events/hr) and ODI (from 46.7 ± 29.8 to 5.3 ± 2 events/hr; P = .002). Using DISE, we observed that after MMA, the greatest reduction in upper airway collapsibility is seen at the lateral pharyngeal wall of the

  10. Keys to successful diabetes self-management for uninsured patients: social support, observational learning, and turning points: a safety net providers' strategic alliance study.

    PubMed

    Madden, Melissa Hanahan; Tomsik, Philip; Terchek, Joshua; Navracruz, Lisa; Reichsman, Ann; Clark, Terri Clemons; Cella, Peggi; Weirich, Stephen A; Munson, Michelle R; Werner, James J

    2011-03-01

    To examine how medically uninsured patients who receive health care at federally qualified health centers and free clinics are able to successfully self-manage diabetes compared to patients who are less successful. Two distinct groups of patients with diabetes for 6 months or longer were enrolled: (1) successful, defined as those with glycated hemoglobin (HbA1c) of 7% or less or a recent improvement of at least 2% (n=17); and (2) unsuccessful, defined as patients with HbAlc of at least 9% (n=9) and without recent improvement. Patients were interviewed about enabling factors, motivators, resources, and barriers to diabetes self-management. Data from interviews, chart reviews, and clinician surveys were analyzed using qualitative methods and statistical techniques. African Americans comprised 57.7% of the sample and whites 38.5% (N=26). No significant differences were detected between successful and unsuccessful groups in age, race, education, or employment status. Clinicians rated unsuccessful patients as having more severe diabetes and significantly lower levels of control than successful patients. Compared to unsuccessful patients, successful patients more often reported having friends or family with diabetes, more frequently sought information about the disease, used evidence-based self-management strategies, held more accurate perceptions of their own diabetes control, and experienced "turning point" events that motivated increased efforts in disease management. Patients who successfully managed diabetes learned from diabetic family members and interpreted disease-related events as motivational turning points. It may be beneficial to incorporate social learning and motivational enhancement into diabetes interventions to increase patients' motivation for improved levels of self-management.

  11. Experimental observation of increased threshold electric field for runaway generation due to synchrotron radiation losses in the FTU tokamak

    SciTech Connect

    Martin-Solis, Jose Ramon; Sanchez, Raul; Esposito, Basilio

    2010-01-01

    The threshold electric field for runaway generation has been investigated during runaway suppression experiments by means of electron-cyclotron-resonance heating in the flattop phase of FTU discharges. Runaway suppression has been experimentally found to occur at electric fields substantially larger than those predicted by the relativistic collisional theory of runaway generation, E{sub R} = n{sub e}e{sup 3}ln{Lambda}/4{pi}{var_epsilon}{sub 0}{sup 2}m{sub e}c{sup 2}. These experimental results are consistent with an increase of the critical electric field due to the electron synchrotron radiation losses. No runaway electrons are found in FTU experiments below the radiation threshold. These results support evidence for a new threshold electric field for runaway generation that accounts for the effect of the synchrotron losses, and which should be considered when making predictions on runaway generation and mitigation in devices such as ITER.

  12. Northeast storms ranked by wind stress and wave-generated bottom stress observed in Massachusetts Bay, 1990-2006

    USGS Publications Warehouse

    Butman, B.; Sherwood, C.R.; Dalyander, P.S.

    2008-01-01

    Along the coast of the northeastern United States, strong winds blowing from the northeast are often associated with storms called northeasters, coastal storms that strongly influence weather. In addition to effects caused by wind stress, the sea floor is affected by bottom stress associated with these storms. Bottom stress caused by orbital velocities associated with surface waves integrated over the duration of a storm is a metric of storm strength at the sea floor. Near-bottom wave-orbital velocities calculated by using measurements of significant wave height and dominant wave period and the parametric spectral method described in Wiberg and Sherwood [Wiberg, P.L., Sherwood, C.R. Calculating wave-generated bottom orbital velocities from surface wave parameters. Computers in Geosciences, in press] compared well with observations in Massachusetts Bay. Integrated bottom-wave stress (called IWAVES), calculated at 30 m water depth, and a companion storm-strength metric, integrated surface wind stress at 10 m (called IWINDS), are used to provide an overview of the strength, frequency, and timing of large storms in Massachusetts Bay over a 17-year period from January 1990 through December 2006. These new metrics reflect both storm duration and intensity. Northeast storms were the major cause of large waves in Massachusetts Bay because of the long fetch to the east: of the strongest 10% of storms (n=38) ranked by IWAVES, 22 had vector-averaged wind stress from the northeast quadrant. The Blizzard of December 1992, the Perfect Storm of October 1991, and a December 2003 storm were the strongest three storms ranked by IWAVES and IWINDS, and all were northeasters. IWAVES integrated over the winter season (defined as October-May) ranged by about a factor of 11; the winters with the highest integrated IWAVES were 1992-1993 and 2004-2005 and the winter with the lowest integrated IWAVES was 2001-2002. May 2005 was the only month in the 17-year record that two of the nine

  13. PAHs and the Diffuse Interstellar Bands. What have we Learned from the New Generation of Laboratory and Observational Studies?

    NASA Technical Reports Server (NTRS)

    Salama, Farid

    2005-01-01

    Polycyclic Aromatic Hydrocarbons (PAHs) are an important and ubiquitous component of carbon-bearing materials in space. PAHs are the best-known candidates to account for the IR emission bands (UIR bands) and PAH spectral features are now being used as new probes of the ISM. PAHs are also thought to be among the carriers of the diffuse interstellar absorption bands (DIBs). In the model dealing with the interstellar spectral features, PAHs are present as a mixture of radicals, ions and neutral species. PAH ionization states reflect the ionization balance of the medium while PAH size, composition, and structure reflect the energetic and chemical history of the medium. A major challenge for laboratory astrophysics is to reproduce (in a realistic way) the physical conditions that exist in the emission and/or absorption interstellar zones, An extensive laboratory program has been developed at NASA Ames to characterize the physical and chemical properties of PAHs in astrophysical environments and to describe how they influence the radiation and energy balance in space and the interstellar chemistry. In particular, laboratory experiments provide measurements of the spectral characteristics of interstellar PAH analogs from the ultraviolet and visible range to the infrared range for comparison with astronomical data. This paper will focus on the recent progress made in the laboratory to measure the direct absorption spectra of neutral and ionized PAHs in the gas phase in the near-W and visible range in astrophysically relevant environments. These measurements provide data on PAHs and nanometer-sized particles that can now be directly compared to astronomical observations. The harsh physical conditions of the IS medium - characterized by a low temperature, an absence of collisions and strong V W radiation fields - are simulated in the laboratory by associating a molecular beam with an ionizing discharge to generate a cold plasma expansion. PAH ions are formed from the neutral

  14. PAHs and the Diffuse Interstellar Bands. What have we Learned from the New Generation of Laboratory and Observational Studies?

    NASA Technical Reports Server (NTRS)

    Salama, Farid

    2005-01-01

    Polycyclic Aromatic Hydrocarbons (PAHs) are an important and ubiquitous component of carbon-bearing materials in space. PAHs are the best-known candidates to account for the IR emission bands (UIR bands) and PAH spectral features are now being used as new probes of the ISM. PAHs are also thought to be among the carriers of the diffuse interstellar absorption bands (DIBs). In the model dealing with the interstellar spectral features, PAHs are present as a mixture of radicals, ions and neutral species. PAH ionization states reflect the ionization balance of the medium while PAH size, composition, and structure reflect the energetic and chemical history of the medium. A major challenge for laboratory astrophysics is to reproduce (in a realistic way) the physical conditions that exist in the emission and/or absorption interstellar zones, An extensive laboratory program has been developed at NASA Ames to characterize the physical and chemical properties of PAHs in astrophysical environments and to describe how they influence the radiation and energy balance in space and the interstellar chemistry. In particular, laboratory experiments provide measurements of the spectral characteristics of interstellar PAH analogs from the ultraviolet and visible range to the infrared range for comparison with astronomical data. This paper will focus on the recent progress made in the laboratory to measure the direct absorption spectra of neutral and ionized PAHs in the gas phase in the near-W and visible range in astrophysically relevant environments. These measurements provide data on PAHs and nanometer-sized particles that can now be directly compared to astronomical observations. The harsh physical conditions of the IS medium - characterized by a low temperature, an absence of collisions and strong V W radiation fields - are simulated in the laboratory by associating a molecular beam with an ionizing discharge to generate a cold plasma expansion. PAH ions are formed from the neutral

  15. High variance in reproductive success generates a false signature of a genetic bottleneck in populations of constant size: a simulation study

    PubMed Central

    2013-01-01

    Background Demographic bottlenecks can severely reduce the genetic variation of a population or a species. Establishing whether low genetic variation is caused by a bottleneck or a constantly low effective number of individuals is important to understand a species’ ecology and evolution, and it has implications for conservation management. Recent studies have evaluated the power of several statistical methods developed to identify bottlenecks. However, the false positive rate, i.e. the rate with which a bottleneck signal is misidentified in demographically stable populations, has received little attention. We analyse this type of error (type I) in forward computer simulations of stable populations having greater than Poisson variance in reproductive success (i.e., variance in family sizes). The assumption of Poisson variance underlies bottleneck tests, yet it is commonly violated in species with high fecundity. Results With large variance in reproductive success (Vk ≥ 40, corresponding to a ratio between effective and census size smaller than 0.1), tests based on allele frequencies, allelic sizes, and DNA sequence polymorphisms (heterozygosity excess, M-ratio, and Tajima’s D test) tend to show erroneous signals of a bottleneck. Similarly, strong evidence of population decline is erroneously detected when ancestral and current population sizes are estimated with the model based method MSVAR. Conclusions Our results suggest caution when interpreting the results of bottleneck tests in species showing high variance in reproductive success. Particularly in species with high fecundity, computer simulations are recommended to confirm the occurrence of a population bottleneck. PMID:24131797

  16. Grit under Duress: Stress, Strengths, and Academic Success Among Non-Citizen and Citizen Latina/o First-Generation College Students

    ERIC Educational Resources Information Center

    O'Neal, Colleen R.; Espino, Michelle M.; Goldthrite, Antoinette; Morin, Molly F.; Weston, Lynsey; Hernandez, Pamela; Fuhrmann, Amy

    2016-01-01

    Undocumented Latina/o college students face obstacles and stressors; their stressful experiences and academic strengths merit empirical attention. This cross-sectional, mixed-methods study explored stress, depression, grit, and grade point average (GPA) of 84 non-citizen, Latina/o first-generation college students with a comparison group of 180…

  17. Grit under Duress: Stress, Strengths, and Academic Success Among Non-Citizen and Citizen Latina/o First-Generation College Students

    ERIC Educational Resources Information Center

    O'Neal, Colleen R.; Espino, Michelle M.; Goldthrite, Antoinette; Morin, Molly F.; Weston, Lynsey; Hernandez, Pamela; Fuhrmann, Amy

    2016-01-01

    Undocumented Latina/o college students face obstacles and stressors; their stressful experiences and academic strengths merit empirical attention. This cross-sectional, mixed-methods study explored stress, depression, grit, and grade point average (GPA) of 84 non-citizen, Latina/o first-generation college students with a comparison group of 180…

  18. Vorticity Field from Successive Wake Vortices

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The two-dimensional version of the Terminal Area Simulation System (TASS) was used to numerically simulate the interaction of wake vortices from closely separated aircraft. The aircraft parameters and separations are taken from observed data at an actual airport. The wake vortices are generated near the runway threshold for four successive aircraft. The ambient conditions are characterized by light crosswinds and stable stratification. This movie shows the time sequence of the vorticity field from the successive wake vortices. Apparent are the interactions between each pair of successive wake vortices and the ground.

  19. Observations on the removal of brood inoculated with Tropilaelaps mercedesae (Mesostigmata: Laelapidae) and the mite’s reproductive success in Apis mellifera colonies

    USDA-ARS?s Scientific Manuscript database

    This study assessed the response of Apis mellifera to brood deliberately infested with Tropilaelaps mercedesae. The reproductive success of T. mercedesae in mite-inoculated and naturally infested brood was also compared. The presence of T. mercedesae inside brood cells significantly affected brood ...

  20. Keys to Successful Diabetes Self-Management for Uninsured Patients: Social Support, Observational Learning, and Turning Points A Safety Net Providers’ Strategic Alliance Study

    PubMed Central

    Hanahan, Melissa A.; Werner, James J.; Tomsik, Phillip; Weirich, Stephen A.; Reichsman, Ann; Navracruz, Lisa; Clemons-Clark, Terri; Cella, Peggi; Terchek, Joshua; Munson, Michelle R.

    2015-01-01

    Objective To determine how medically uninsured patients with limited material resources successfully manage diabetes. Methods Clinicians at 5 safety net practices enrolled uninsured adult patients (N=26) with prior diagnosis of diabetes for 6 months or longer. Patients were interviewed about enabling factors, motivations, resources, and barriers. Chart reviews and clinician surveys supplemented interview data. Interview, survey, and chart review data were analyzed and findings were summarized. Results Two distinct groups of patients were investigated: 1) “successful,” defined as those with an HbA1c of ≤7% or a recent improvement of at least 2% (n=17); and 2) “unsuccessful,” defined as patients with HbA1c of ≥9% (n=9) without recent improvement. In comparison to unsuccessful patients, successful patients more often reported having friends or family with diabetes, sought information about the disease, used evidence-based self-management strategies, held an accurate perception of their own disease control, and experienced “turning point” events that motivated increased efforts in disease management. Conclusions Uninsured safety net patients who successfully managed diabetes learned from friends and family with diabetes and leveraged disease-related events into motivational turning points. It may be beneficial for clinicians to incorporate social learning and motivational enhancement into diabetes interventions to increase patients’ motivation for improved levels of self-management. PMID:21671529

  1. Direct observation of hexamethylbenzenium radical cations generated during zeolite methanol-to-olefin catalysis: an ESR study.

    PubMed

    Kim, Sun Jung; Jang, Hoi-Gu; Lee, Jun Kyu; Min, Hyung-Ki; Hong, Suk Bong; Seo, Gon

    2011-09-07

    The generation of hexamethylbenzenium radical cations as the key reaction intermediate in chabazite-type molecular sieve acids (i.e., H-SAPO-34 and H-SSZ-13) during the methanol-to-olefin process has been directly evidenced by ESR spectroscopy.

  2. Real-time observation of coherent acoustic phonons generated by an acoustically mismatched optoacoustic transducer using x-ray diffraction

    SciTech Connect

    Persson, A. I. H.; Andreasson, B. P.; Enquist, H.; Jurgilaitis, A.; Larsson, J.

    2015-11-14

    The spectrum of laser-generated acoustic phonons in indium antimonide coated with a thin nickel film has been studied using time-resolved x-ray diffraction. Strain pulses that can be considered to be built up from coherent phonons were generated in the nickel film by absorption of short laser pulses. Acoustic reflections at the Ni–InSb interface leads to interference that strongly modifies the resulting phonon spectrum. The study was performed with high momentum transfer resolution together with high time resolution. This was achieved by using a third-generation synchrotron radiation source that provided a high-brightness beam and an ultrafast x-ray streak camera to obtain a temporal resolution of 10 ps. We also carried out simulations, using commercial finite element software packages and on-line dynamic diffraction tools. Using these tools, it is possible to calculate the time-resolved x-ray reflectivity from these complicated strain shapes. The acoustic pulses have a peak strain amplitude close to 1%, and we investigated the possibility to use this device as an x-ray switch. At a bright source optimized for hard x-ray generation, the low reflectivity may be an acceptable trade-off to obtain a pulse duration that is more than an order of magnitude shorter.

  3. Validation of Autoclave Protocols for Successful Decontamination of Category A Medical Waste Generated from Care of Patients with Serious Communicable Diseases

    PubMed Central

    Reimers, Mallory; Ernst, Neysa; Bova, Gregory; Nowakowski, Elaine; Bukowski, James; Ellis, Brandon C.; Smith, Chris; Sauer, Lauren; Dionne, Kim; Carroll, Karen C.; Maragakis, Lisa L.; Parrish, Nicole M.

    2016-01-01

    ABSTRACT In response to the Ebola outbreak in 2014, many hospitals designated specific areas to care for patients with Ebola and other highly infectious diseases. The safe handling of category A infectious substances is a unique challenge in this environment. One solution is on-site waste treatment with a steam sterilizer or autoclave. The Johns Hopkins Hospital (JHH) installed two pass-through autoclaves in its biocontainment unit (BCU). The JHH BCU and The Johns Hopkins biosafety level 3 (BSL-3) clinical microbiology laboratory designed and validated waste-handling protocols with simulated patient trash to ensure adequate sterilization. The results of the validation process revealed that autoclave factory default settings are potentially ineffective for certain types of medical waste and highlighted the critical role of waste packaging in successful sterilization. The lessons learned from the JHH validation process can inform the design of waste management protocols to ensure effective treatment of highly infectious medical waste. PMID:27927920

  4. Validation of Autoclave Protocols for Successful Decontamination of Category A Medical Waste Generated from Care of Patients with Serious Communicable Diseases.

    PubMed

    Garibaldi, Brian T; Reimers, Mallory; Ernst, Neysa; Bova, Gregory; Nowakowski, Elaine; Bukowski, James; Ellis, Brandon C; Smith, Chris; Sauer, Lauren; Dionne, Kim; Carroll, Karen C; Maragakis, Lisa L; Parrish, Nicole M

    2017-02-01

    In response to the Ebola outbreak in 2014, many hospitals designated specific areas to care for patients with Ebola and other highly infectious diseases. The safe handling of category A infectious substances is a unique challenge in this environment. One solution is on-site waste treatment with a steam sterilizer or autoclave. The Johns Hopkins Hospital (JHH) installed two pass-through autoclaves in its biocontainment unit (BCU). The JHH BCU and The Johns Hopkins biosafety level 3 (BSL-3) clinical microbiology laboratory designed and validated waste-handling protocols with simulated patient trash to ensure adequate sterilization. The results of the validation process revealed that autoclave factory default settings are potentially ineffective for certain types of medical waste and highlighted the critical role of waste packaging in successful sterilization. The lessons learned from the JHH validation process can inform the design of waste management protocols to ensure effective treatment of highly infectious medical waste.

  5. A narrow amide I vibrational band observed by sum frequency generation spectroscopy reveals highly ordered structures of a biofilm protein at the air/water interface.

    PubMed

    Wang, Zhuguang; Morales-Acosta, M Daniela; Li, Shanghao; Liu, Wei; Kanai, Tapan; Liu, Yuting; Chen, Ya-Na; Walker, Frederick J; Ahn, Charles H; Leblanc, Roger M; Yan, Elsa C Y

    2016-02-18

    We characterized BslA, a bacterial biofilm protein, at the air/water interface using vibrational sum frequency generation spectroscopy and observed one of the sharpest amide I bands ever reported. Combining methods of surface pressure measurements, thin film X-ray reflectivity, and atomic force microscopy, we showed extremely ordered BslA at the interface.

  6. Successful Lecturing

    PubMed Central

    Copeland, H Liesel; Longworth, David L; Hewson, Mariana G; Stoller, James K

    2000-01-01

    OBJECTIVE In a study conducted over 3 large symposia on intensive review of internal medicine, we previously assessed the features that were most important to course participants in evaluating the quality of a lecture. In this study, we attempt to validate these observations by assessing prospectively the extent to which ratings of specific lecture features would predict the overall evaluation of lectures. MEASUREMENTS AND MAIN RESULTS After each lecture, 143 to 355 course participants rated the overall lecture quality of 69 speakers involved in a large symposium on intensive review of internal medicine. In addition, 7 selected participants and the course directors rated specific lecture features and overall quality for each speaker. The relations among the variables were assessed through Pearson correlation coefficients and cluster analysis. Regression analysis was performed to determine which features would predict the overall lecture quality ratings. The features that most highly correlated with ratings of overall lecture quality were the speaker's abilities to identify key points (r = .797) and be engaging (r = .782), the lecture clarity (r = .754), and the slide comprehensibility (r = .691) and format (r = .660). The three lecture features of engaging the audience, lecture clarity, and using a case-based format were identified through regression as the strongest predictors of overall lecture quality ratings (R2= 0.67, P = 0.0001). CONCLUSIONS We have identified core lecture features that positively affect the success of the lecture. We believe our findings are useful for lecturers wanting to improve their effectiveness and for educators who design continuing medical education curricula. PMID:10886470

  7. Real-Space Observation of Nonvolatile Zero-Field Biskyrmion Lattice Generation in MnNiGa Magnet.

    PubMed

    Peng, Licong; Zhang, Ying; Wang, Wenhong; He, Min; Li, Lailai; Ding, Bei; Li, Jianqi; Sun, Young; Zhang, X-G; Cai, Jianwang; Wang, Shouguo; Wu, Guangheng; Shen, Baogen

    2017-10-09

    Magnetic skyrmions, particular those without the support of external magnetic fields over a wide temperature region, are promising as alternative spintronic units to overcome the fundamental size limitation of conventional magnetic bits. In this study, we use in situ Lorentz microscope to directly demonstrate the generation and sustainability of robust biskyrmion lattice at zero magnetic field over a wide temperature range of 16-338 K in MnNiGa alloy. This procedure includes a simple field-cooling manipulation from 360 K (higher than Curie temperature TC ∼ 350 K), where topological transition easily occurs by adapting the short-range magnetic clusters under a certain magnetic field. The biskyrmion phase is favored upon cooling below TC. Once they are generated, the robust high-density biskyrmions persist even after removing the external magnetic field due to the topological protection and the increased energy barrier.

  8. A Study on the Observation of Direct Lightning Current through the Wind Turbine Generator System in the Coast of the Japan Sea

    NASA Astrophysics Data System (ADS)

    Shiraishi, Yasuhiro; Otsuka, Takahiro; Matsuura, Hideki

    As clean energy that solves energy resources, many wind turbine generator systems have developed up to now, in Japan. The generation capacity of wind power is above 1 million kW, and the construction also continues from now on. The wind turbine generator systems are built in the good place of the wind condition, and those many are built on the coast of the Japan Sea. However, the coast of the Japan Sea is known as a place with much winter lightning, and wind turbine generator systems also often suffer the damage by winter lightning. The authors observed the lightning current that strikes through the wind turbine generator systems directly, in order to establish on the lightning protection of them. The authors acquired dozens of data as a result of observation in Akita Japan for 17 months. Based on these data, some considerations were performed about the performance of winter lightning that struck through the wind turbine generator systems. As the result of consideration, we found some interesting knowledge following sentence. It made clear anew that the tower which is a place of high position from the ground and on the windward has much number of lightning flash and many total flash charges. The lightning stroke current divided the tower pipe and ground leads. About 70% of the observed lightning current flowed to the tower pipe, and about 30% is divided into two grounding leads connected to the leg of tower. All of steep current that is on a wave front flow a tower side, it dose not flow to a grounding leads side. The distributions of lightning parameters between our observation results and past one are in good conformity.

  9. Bird Migration Echoes Observed by Polarimetric Radar

    NASA Astrophysics Data System (ADS)

    Minda, Haruya; Furuzawa, Fumie A.; Satoh, Shinsuke; Nakamura, Kenji

    A C-band polarimetric radar on Okinawa Island successfully observed large-scale bird migrations over the western Pacific Ocean. The birds generated interesting polarimetric signatures. This paper describes the signatures and speculates bird behavior.

  10. Successful Predictions

    NASA Astrophysics Data System (ADS)

    Pierrehumbert, R.

    2012-12-01

    In an observational science, it is not possible to test hypotheses through controlled laboratory experiments. One can test parts of the system in the lab (as is done routinely with infrared spectroscopy of greenhouse gases), but the collective behavior cannot be tested experimentally because a star or planet cannot be brought into the lab; it must, instead, itself be the lab. In the case of anthropogenic global warming, this is all too literally true, and the experiment would be quite exciting if it weren't for the unsettling fact that we and all our descendents for the forseeable future will have to continue making our home in the lab. There are nonetheless many routes though which the validity of a theory of the collective behavior can be determined. A convincing explanation must not be a"just-so" story, but must make additional predictions that can be verified against observations that were not originally used in formulating the theory. The field of Earth and planetary climate has racked up an impressive number of such predictions. I will also admit as "predictions" statements about things that happened in the past, provided that observations or proxies pinning down the past climate state were not available at the time the prediction was made. The basic prediction that burning of fossil fuels would lead to an increase of atmospheric CO2, and that this would in turn alter the Earth's energy balance so as to cause tropospheric warming, is one of the great successes of climate science. It began in the lineage of Fourier, Tyndall and Arrhenius, and was largely complete with the the radiative-convective modeling work of Manabe in the 1960's -- all well before the expected warming had progressed far enough to be observable. Similarly, long before the increase in atmospheric CO2 could be detected, Bolin formulated a carbon cycle model and used it to predict atmospheric CO2 out to the year 2000; the actual values come in at the high end of his predicted range, for

  11. Butterfly Pitch Angle Distributions Generated at Low L Values During March 2015 Storm: Van Allen Probe ECT Observations

    NASA Astrophysics Data System (ADS)

    Fennell, J. F.; Kanekal, S.; Claudepierre, S. G.; Blake, J. B.; O'Brien, T. P., III; Turner, D. L.; Baker, D. N.; Spence, H. E.; Geoffrey, R.

    2015-12-01

    The 17 March 2015 magnetic storm was the largest storm (DST<-220 nT) in the Van Allen Probes era so far. Near the end of the main phase and during the early recovery phase of this storm the ECT MagEIS and REPT sensors observed electrons with "butterfly" type pitch angle distributions with relative minima at 90° equatorial pitch angles. The "butterfly" distributions were observed at energies that spanned the range from 32 keV to ~5 MeV. These pitch angle distributions occurred over an energy- dependent range of L-shells from L~1.5 in the inner zone out to L~3 in the slot region. In general, they occurred at the deepest L penetration point for the individual energies. We will present these observations and discuss their relationship to earlier observations and recently published simulation results.

  12. Role of generation, architecture, pH and ionic strength on successful siRNA delivery and transfection by hybrid PPV-PAMAM dendrimers.

    PubMed

    Pavan, G M; Monteagudo, S; Guerra, J; Carrión, B; Ocaña, V; Rodríguez-Lopez, J; Danani, A; Pérez-Martínez, F C; Ceña, V

    2012-01-01

    Small interfering RNA (siRNA) constitutes an excellent way of knocking down genes. However, it requires the use of delivery systems to reach the target cells, especially to neuronal cells. Dendrimers are one of the most widely used synthetic nanocarriers for siRNA delivery. However, due to the complexity of the dendrimer-siRNA interactions, when a new dendritic carrier is designed it is difficult to predict its efficiency to bind and to deliver siRNA. At the same time it is not easy to understand the origin of eventual limited functionalities. We have modeled the interactions between two dendrimers (TDG-G1 and TDG-G2) and siRNA using molecular dynamics (MD) simulation. The results were compared to experimental physico-chemical parameters such as siRNA complexation, complex stability, size, and zeta potentials and biological effects such as down-regulation of a specific RNA expression in cortical neurons in culture. Data indicate that the combination of rigid core and flexible branches guarantees strong siRNA binding, which is important to have a good transfection profile. However, the successful nanocarrier for siRNA delivery (TDG-G1) is identified not only by a high affinity for siRNA, but by a favorable equilibrium between a strong binding and the ability to release siRNA to exert its biological action. The conditions under which the dendriplex is formed are also relevant for transfection efficiency and biological activity.

  13. Achieving high treatment success for multidrug-resistant TB in Africa: initiation and scale-up of MDR TB care in Ethiopia—an observational cohort study

    PubMed Central

    Meressa, Daniel; Hurtado, Rocío M; Andrews, Jason R; Diro, Ermias; Abato, Kassim; Daniel, Tewodros; Prasad, Paritosh; Prasad, Rebekah; Fekade, Bekele; Tedla, Yared; Yusuf, Hanan; Tadesse, Melaku; Tefera, Dawit; Ashenafi, Abraham; Desta, Girma; Aderaye, Getachew; Olson, Kristian; Thim, Sok; Goldfeld, Anne E

    2015-01-01

    Background In Africa, fewer than half of patients receiving therapy for multidrug-resistant TB (MDR TB) are successfully treated, with poor outcomes reported for HIV-coinfected patients. Methods A standardised second-line drug (SLD) regimen was used in a non-governmental organisation–Ministry of Health (NGO-MOH) collaborative community and hospital-based programme in Ethiopia that included intensive side effect monitoring, adherence strategies and nutritional supplementation. Clinical outcomes for patients with at least 24 months of follow-up were reviewed and predictors of treatment failure or death were evaluated by Cox proportional hazards models. Results From February 2009 to December 2014, 1044 patients were initiated on SLD. 612 patients with confirmed or presumed MDR TB had ≥24 months of follow-up, 551 (90.0%) were confirmed and 61 (10.0%) were suspected MDR TB cases. 603 (98.5%) had prior TB treatment, 133 (21.7%) were HIV coinfected and median body mass index (BMI) was 16.6. Composite treatment success was 78.6% with 396 (64.7%) cured, 85 (13.9%) who completed treatment, 10 (1.6%) who failed, 85 (13.9%) who died and 36 (5.9%) who were lost to follow-up. HIV coinfection (adjusted HR (AHR): 2.60, p<0.001), BMI (AHR 0.88/kg/m2, p=0.006) and cor pulmonale (AHR 3.61, p=0.003) and confirmed MDR TB (AHR 0.50, p=0.026) were predictive of treatment failure or death. Conclusions We report from Ethiopia the highest MDR TB treatment success outcomes so far achieved in Africa, in a setting with severe resource constraints and patients with advanced disease. Intensive treatment of adverse effects, nutritional supplementation, adherence interventions and NGO-MOH collaboration were key strategies contributing to success. We argue these approaches should be routinely incorporated into programmes. PMID:26506854

  14. Observation of cone and rod photoreceptors in normal subjects and patients using a new generation adaptive optics scanning laser ophthalmoscope

    PubMed Central

    Merino, David; Duncan, Jacque L.; Tiruveedhula, Pavan; Roorda, Austin

    2011-01-01

    We demonstrate the capability of a new generation adaptive optics scanning laser ophthalmoscope (AOSLO) to resolve cones and rods in normal subjects, and confirm our findings by comparing cone and rod spacing with published histology measurements. Cone and rod spacing measurements are also performed on AOSLO images from two different diseased eyes, one affected by achromatopsia and the other by acute zonal occult outer retinopathy (AZOOR). The potential of AOSLO technology in the study of these and other retinal diseases is illustrated. PMID:21833357

  15. High-harmonic generation from an atomically thin semiconductor [Observation of high harmonics from an atomically thin semiconductor

    DOE PAGES

    Liu, Hanzhe; Li, Yilei; You, Yong Sing; ...

    2016-11-14

    High-harmonic generation (HHG) in bulk solids permits the exploration of materials in a new regime of strong fields and attosecond timescales. The generation process has been discussed in the context of strongly driven electron dynamics in single-particle bands. Two-dimensional materials exhibit distinctive electronic properties compared to the bulk that could significantly modify the HHG process, including different symmetries, access to individual valleys and enhanced many-body interactions. Here we demonstrate non-perturbative HHG from a monolayer MoS2 crystal, with even and odd harmonics extending to the 13th order. The even orders are predominantly polarized perpendicular to the pump and are compatible withmore » the anomalous transverse intraband current arising from the material’s Berry curvature, while the weak parallel component suggests the importance of interband transitions. The odd harmonics exhibit a significant enhancement in efficiency per layer compared to the bulk, which is attributed to correlation effects. In conclusion, the combination of strong many-body Coulomb interactions and widely tunable electronic properties in two-dimensional materials offers a new platform for attosecond physics.« less

  16. High-harmonic generation from an atomically thin semiconductor [Observation of high harmonics from an atomically thin semiconductor

    SciTech Connect

    Liu, Hanzhe; Li, Yilei; You, Yong Sing; Ghimire, Shambhu; Heinz, Tony F.; Reis, David A.

    2016-11-14

    High-harmonic generation (HHG) in bulk solids permits the exploration of materials in a new regime of strong fields and attosecond timescales. The generation process has been discussed in the context of strongly driven electron dynamics in single-particle bands. Two-dimensional materials exhibit distinctive electronic properties compared to the bulk that could significantly modify the HHG process, including different symmetries, access to individual valleys and enhanced many-body interactions. Here we demonstrate non-perturbative HHG from a monolayer MoS2 crystal, with even and odd harmonics extending to the 13th order. The even orders are predominantly polarized perpendicular to the pump and are compatible with the anomalous transverse intraband current arising from the material’s Berry curvature, while the weak parallel component suggests the importance of interband transitions. The odd harmonics exhibit a significant enhancement in efficiency per layer compared to the bulk, which is attributed to correlation effects. In conclusion, the combination of strong many-body Coulomb interactions and widely tunable electronic properties in two-dimensional materials offers a new platform for attosecond physics.

  17. The Value of a Well-Being Improvement Strategy: Longitudinal Success across Subjective and Objective Measures Observed in a Firm Adopting a Consumer-Driven Health Plan.

    PubMed

    Guo, Xiaobo; Coberley, Carter; Pope, James E; Wells, Aaron

    2015-10-01

    The objective of this study is to evaluate effectiveness of a firm's 5-year strategy toward improving well-being while lowering health care costs amidst adoption of a Consumer-Driven Health Plan. Repeated measures statistical models were employed to test and quantify association between key demographic factors, employment type, year, individual well-being, and outcomes of health care costs, obesity, smoking, absence, and performance. Average individual well-being trended upward by 13.5% over 5 years, monthly allowed amount health care costs declined 5.2% on average per person per year, and obesity and smoking rates declined by 4.8 and 9.7%, respectively, on average each year. The results show that individual well-being was significantly associated with each outcome and in the expected direction. The firm's strategy was successful in driving statistically significant, longitudinal well-being, biometric and productivity improvements, and health care cost reduction.

  18. Waste Generator Instructions: Key to Successful Implementation of the US DOE's 435.1 for Transuranic Waste Packaging Instructions (LA-UR-12-24155) - 13218

    SciTech Connect

    French, David M.; Hayes, Timothy A.; Pope, Howard L.; Enriquez, Alejandro E.; Carson, Peter H.

    2013-07-01

    In times of continuing fiscal constraints, a management and operation tool that is straightforward to implement, works as advertised, and virtually ensures compliant waste packaging should be carefully considered and employed wherever practicable. In the near future, the Department of Energy (DOE) will issue the first major update to DOE Order 435.1, Radioactive Waste Management. This update will contain a requirement for sites that do not have a Waste Isolation Pilot Plant (WIPP) waste certification program to use two newly developed technical standards: Contact-Handled Defense Transuranic Waste Packaging Instructions and Remote-Handled Defense Transuranic Waste Packaging Instructions. The technical standards are being developed from the DOE O 435.1 Notice, Contact-Handled and Remote-Handled Transuranic Waste Packaging, approved August 2011. The packaging instructions will provide detailed information and instruction for packaging almost every conceivable type of transuranic (TRU) waste for disposal at WIPP. While providing specificity, the packaging instructions leave to each site's own discretion the actual mechanics of how those Instructions will be functionally implemented at the floor level. While the Technical Standards are designed to provide precise information for compliant packaging, the density of the information in the packaging instructions necessitates a type of Rosetta Stone that translates the requirements into concise, clear, easy to use and operationally practical recipes that are waste stream and facility specific for use by both first line management and hands-on operations personnel. The Waste Generator Instructions provide the operator with step-by-step instructions that will integrate the sites' various operational requirements (e.g., health and safety limits, radiological limits or dose limits) and result in a WIPP certifiable waste and package that can be transported to and emplaced at WIPP. These little known but widely productive Waste

  19. Lightning-Generated Whistler Waves Observed by Probes On The Communication/Navigation Outage Forecast System Satellite at Low Latitudes

    NASA Technical Reports Server (NTRS)

    Holzworth, R. H.; McCarthy, M. P.; Pfaff, R. F.; Jacobson, A. R.; Willcockson, W. L.; Rowland, D. E.

    2011-01-01

    Direct evidence is presented for a causal relationship between lightning and strong electric field transients inside equatorial ionospheric density depletions. In fact, these whistler mode plasma waves may be the dominant electric field signal within such depletions. Optical lightning data from the Communication/Navigation Outage Forecast System (C/NOFS) satellite and global lightning location information from the World Wide Lightning Location Network are presented as independent verification that these electric field transients are caused by lightning. The electric field instrument on C/NOFS routinely measures lightning ]related electric field wave packets or sferics, associated with simultaneous measurements of optical flashes at all altitudes encountered by the satellite (401.867 km). Lightning ]generated whistler waves have abundant access to the topside ionosphere, even close to the magnetic equator.

  20. Lightning-Generated Whistler Waves Observed by Probes On The Communication/Navigation Outage Forecast System Satellite at Low Latitudes

    NASA Technical Reports Server (NTRS)

    Holzworth, R. H.; McCarthy, M. P.; Pfaff, R. F.; Jacobson, A. R.; Willcockson, W. L.; Rowland, D. E.

    2011-01-01

    Direct evidence is presented for a causal relationship between lightning and strong electric field transients inside equatorial ionospheric density depletions. In fact, these whistler mode plasma waves may be the dominant electric field signal within such depletions. Optical lightning data from the Communication/Navigation Outage Forecast System (C/NOFS) satellite and global lightning location information from the World Wide Lightning Location Network are presented as independent verification that these electric field transients are caused by lightning. The electric field instrument on C/NOFS routinely measures lightning ]related electric field wave packets or sferics, associated with simultaneous measurements of optical flashes at all altitudes encountered by the satellite (401.867 km). Lightning ]generated whistler waves have abundant access to the topside ionosphere, even close to the magnetic equator.

  1. Three observational differences for binary black holes detections with second- and third-generation gravitational-wave detectors

    NASA Astrophysics Data System (ADS)

    Vitale, Salvatore

    2016-12-01

    Advanced gravitational-wave observatories, such as LIGO and Virgo, will detect hundreds of gravitational-wave signals emitted by binary black holes in the next few years. The collection of detected sources is expected to have certain properties. It is expected that a selection bias will exist toward higher-mass systems, that most events will be oriented with their angular momentum pointing to or away from Earth, and that quiet events will be much more numerous than loud events. In this paper, we show how all these assumptions are only true for existing detectors and do not have any universality. Using a network of proposed third-generation gravitational-wave detectors, we show how each of these assumptions must be revised, and we discuss several consequences on the characterization of the sources.

  2. Surface defects generated by intrinsic origins on 4H-SiC epitaxial wafers observed by scanning electron microscopy.

    PubMed

    Matsuhata, Hirofumi; Sugiyama, Naoyuki; Chen, Bin; Yamashita, Tamotsu; Hatakeyama, Tetsuo; Sekiguchi, Takashi

    2017-04-01

    Surface defects with intrinsic origins in an epitaxial layer on 4H-SiC wafers were observed by scanning electron microscopy. Commercially available 4H-SiC epitaxial wafers with 4° or 8° off-axis angles from the [0001] direction toward the [112¯0] direction were used in this experiment. Various types of defects, including micropipes, pits, carrots, stacking faults and wide terrace and high step structures, were observed and clearly identified. The defects are presented as a catalog that can be used in the identification of surface defects. © The Author 2016. Published by Oxford University Press on behalf of The Japanese Society of Microscopy. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  3. Numerical simulation and observations of very severe cyclone generated surface wave fields in the north Indian Ocean

    NASA Astrophysics Data System (ADS)

    Sirisha, P.; Remya, P. G.; Balakrishnan Nair, T. M.; Rao, B. Venkateswara

    2015-12-01

    Accurate wave forecast is most needed during tropical cyclones as it has adverse effects on the entire marine activities. The present work evaluates the performance of a wave forecasting system under very severe cyclonic conditions for the Indian Ocean. The wave model results are validated separately for the deep water and shallow water using in-situ observations. Satellite altimeter observations are also utilized for validation purpose. The results show that the model performance is accurate (SI < 26% and correlation > 0.9) and consistent during very severe cyclones (categories 4 and 5). The power of the cyclone waves which hit in the eastern Indian coastal region is also analysed and it reveals that the coastal region which lies on the right side of the cyclone track receives high amount wave energy throughout the cyclone period. The study also says that the abnormal waves mostly present on the right side of the track.

  4. Treatment of resistant tattoos using a new generation Q-switched Nd:YAG laser: influence of beam profile and spot size on clearance success.

    PubMed

    Karsai, Syrus; Pfirrmann, Gudrun; Hammes, Stefan; Raulin, Christian

    2008-02-01

    Multiple treatments of resistant tattoos often result in fibrosis and visible textural changes that lessen response to subsequent treatments. The aim of this study is to evaluate the influence of beam profile and spot size on clearance rates and side effects in the setting of resistant tattoos. Thirty-six professional, black tattoos (32 patients) were treated unsuccessfully with a Q-switched Nd:YAG laser (MedLite C3, HoyaConBio Inc., Fremont, CA). Because of therapy resistance all tattoos were re-treated using a new generation Nd:YAG laser (MedLite C6, HoyaConBio Inc.). Maximum energy fluence (E (max)), mean energy fluence, mean spot size, level of clearance, side effects and beam profile (irradiance distribution) of both laser systems were assessed and evaluated in a retrospective study. All tattoos were previously treated with the C3 laser at 1,064 nm using a mean E(max) of 5.8+/-0.8 J/cm(2) (range 3.8-7.5 J/cm(2)) as compared with a mean E(max) of 6.4+/-1.6 J/cm(2) (range 3.2-9.0 J/cm(2)) during the C6 treatment course. Corresponding spot sizes were larger during C6 treatments as compared with C3 (5.0+/-0.9 and 3.6+/-0.2 mm, respectively). The C6 laser had a "flat top" and homogenous profile regardless of the spot size. For the C3 laser the beam shape was "Gaussian," and the homogeneity was reduced by numerous micro-spikes and micro-nadirs. After the C6 treatment course 33.3% of the tattoos showed clearance of grade 1 (0-25%), 16.7% of grade 2 (26-50%), 16.7% of grade 3 (51-75%), 30.5% of grade 4 (76-95%), 2.8% of grade 5 (96-100%). The total rate of side effects due to C6 treatment was 8.3% in all tattoos (hyperpigmentation 5.6%, hypopigmentation 2.7%, textural changes/scars 0%). This clinical study documents for the first time the impact of a 1,064-nm Nd:YAG laser with a more homogenous beam profile and a larger spot size on the management of resistant tattoos. Only a few treatment sessions were necessary to achieve an additional clearance with a low rate of

  5. Training and Mentoring the Next Generation of Scientists and Engineers to Secure Continuity and Successes of the US DOE's Environmental Remediation Efforts - 13387

    SciTech Connect

    Lagos, L.

    2013-07-01

    The DOE Office of Environmental Management (DOE-EM) oversees one of the largest and most technically challenging cleanup programs in the world. The mission of DOE-EM is to complete the safe cleanup of the environmental legacy from five decades of nuclear weapons development and government-sponsored nuclear energy research. Since 1995, Florida International University's Applied Research Center (FIU-ARC) has supported the DOE-EM mission and provided unique research capabilities to address some of these highly technical and difficult challenges. This partnership has allowed FIU-ARC to create a unique infrastructure that is critical for the training and mentoring of science, technology, engineering, and math (STEM) students and has exposed many STEM students to 'hands-on' DOE-EM applied research, supervised by the scientists and engineers at ARC. As a result of this successful partnership between DOE and FIU, DOE requested FIU-ARC to create the DOE-FIU Science and Technology Workforce Development Initiative in 2007. This innovative program was established to create a 'pipeline' of minority STEM students trained and mentored to enter DOE's environmental cleanup workforce. The program was designed to help address DOE's future workforce needs by partnering with academic, government and private companies (DOE contractors) to mentor future minority scientists and engineers in the research, development, and deployment of new technologies and processes addressing DOE's environmental cleanup challenges. Since its inception in 2007, the program has trained and mentored 78 FIU STEM minority students. Although, the program has been in existence for only five years, a total of 75 internships have been conducted at DOE National Laboratories, DOE sites, DOE Headquarters and field offices, and DOE contractors. Over 85 DOE Fellows have participated in the Waste Management Symposia since 2008 with a total of 68 student posters and 7 oral presentations given at WM. The DOE Fellows

  6. Optimizing next-generation operational observation networks for the short-term forecast of Mediterranean high-impact weather

    NASA Astrophysics Data System (ADS)

    Garcies Artigues, L.; Homar Santaner, V.

    2010-09-01

    Weather forecasting authorities are perceiving increasing pressure from the public to extend and improve the quality of short-range predictions while reducing costs and increasing the overall forecasting efficiency. The European community is strongly committed to attain this increased efficiency by focusing on the observational component of the weather forecasting process. One important research commitment is oriented to optimize the integrated observing system networks to achieve better representations of the atmosphere and eventually more accurate forecasts. In this context, sensitivity analysis techniques aim at identifying causal atmospheric structures that have a relevant effect on a particular aspect of interest, such as strong winds or heavy rains. Indeed, information derived from such sensitivity analysis should be the guiding basis for decision makers to focus on areas where an increased observational effort would significantly improve the quality and value of short-range numerical weather predictions across the region. Although several sensitivity calculation techniques exist that aim at computing the relevant areas for a particular weather event -such as those used in real-time targeting campaigns- permanent redesigns of the observational strategies require climatological sensitivity information. However, no consensus exists on how climatological sensitivity information should be derived or even verified in a relevant and useful way. The aim of this work is twofold, on the one side, the essential results from 3 sensitivity climatologies (an adjoint-based and two different ensemble-based) for the short-range prediction of Mediterranean intense cyclones are presented. On the other hand, a verification testbed to evaluate and compare the skill of each climatological sensitivity estimate is developed. The verification of these climatologies is essential to ensure the reliability of the sensitivity products and ultimately provide robust guidance to policy

  7. N-H stretching modes around 3300 wavenumber from peptide backbones observed by chiral sum frequency generation vibrational spectroscopy.

    PubMed

    Fu, Li; Wang, Zhuguang; Yan, Elsa C Y

    2014-09-01

    We present a detailed analysis of the molecular origin of the chiral sum frequency generation (SFG) signals of proteins and peptides at interfaces in the N-H stretching vibrational region. The N-H stretching can be a probe for investigating structural and functional properties of proteins, but remains technically difficult to analyze due to the overlapping with the O-H stretching of water molecules. Chiral SFG spectroscopy offers unique tools to study the N-H stretching from proteins at interfaces without interference from the water background. However, the molecular origin of the N-H stretching signals of proteins is still unclear. This work provides a justification of the origin of chiral N-H signals by analyzing the vibrational frequencies, examining chiral SFG theory, studying proton (hydrogen/deuterium) exchange kinetics, and performing optical control experiments. The results demonstrate that the chiral N-H stretching signals at ~3300 cm(-1) originate from the amide group of the protein backbones. This chiral N-H stretching signal offers an in situ, real-time, and background-free probe for interrogating the protein structures and dynamics at interfaces at the molecular level.

  8. Observation of Charge Inversion of an Ionic Liquid at the Solid Salt-Liquid Interface by Sum Frequency Generation Spectroscopy.

    PubMed

    Peñalber, Chariz Y; Baldelli, Steven

    2012-04-05

    Sum frequency generation (SFG) vibrational spectroscopy of the ionic liquid, 1-butyl-3-methylimidazolium dicyanamide [BMIM][DCA], in contact with two different solid salt surfaces, BaF2(111) single crystal and solid NaCl{100}, are discussed in this Letter. This investigation describes the nature of an ionic liquid-(solid) salt interface using SFG, contributing a new understanding to the molecular-level interactions involved in salts, which are conceptually similar compounds (of purely ionic character) but of different physical properties (liquid versus solid at room temperature). Results show the presence of [BMIM](+) at the NaCl{100} surface and [DCA](-) at the BaF2(111) surface. [BMIM](+) cations adhere closely via Coulombic interactions to the negatively charged NaCl{100} surface, while [DCA](-) anions subsequently have a strong electrostatic affinity to the positively charged BaF2(111) surface. Ions of the ionic liquid adsorb to the solid salt surface to form a Helmholtz-like electric double layer.

  9. High-quality seamless DEM generation blending SRTM-1, ASTER GDEM v2 and ICESat/GLAS observations

    NASA Astrophysics Data System (ADS)

    Yue, Linwei; Shen, Huanfeng; Zhang, Liangpei; Zheng, Xianwei; Zhang, Fan; Yuan, Qiangqiang

    2017-01-01

    The absence of a high-quality seamless global digital elevation model (DEM) dataset has been a challenge for the Earth-related research fields. Recently, the 1-arc-second Shuttle Radar Topography Mission (SRTM-1) data have been released globally, covering over 80% of the Earth's land surface (60°N-56°S). However, voids and anomalies still exist in some tiles, which has prevented the SRTM-1 dataset from being directly used without further processing. In this paper, we propose a method to generate a seamless DEM dataset blending SRTM-1, ASTER GDEM v2, and ICESat laser altimetry data. The ASTER GDEM v2 data are used as the elevation source for the SRTM void filling. To get a reliable filling source, ICESat GLAS points are incorporated to enhance the accuracy of the ASTER data within the void regions, using an artificial neural network (ANN) model. After correction, the voids in the SRTM-1 data are filled with the corrected ASTER GDEM values. The triangular irregular network based delta surface fill (DSF) method is then employed to eliminate the vertical bias between them. Finally, an adaptive outlier filter is applied to all the data tiles. The final result is a seamless global DEM dataset. ICESat points collected from 2003 to 2009 were used to validate the effectiveness of the proposed method, and to assess the vertical accuracy of the global DEM products in China. Furthermore, channel networks in the Yangtze River Basin were also extracted for the data assessment.

  10. Unexpected Generation and Observation of a T-Shaped Complex of H_{2}C_{2}\\cdotsAgCCH

    NASA Astrophysics Data System (ADS)

    Walker, N. R.; Stephens, S. L.; Mizukami, W.; Tew, D. P.; Legon, A. C.

    2013-06-01

    An experiment to probe species generated within a supersonically-expanding jet consisting of SF_{6}, Ag, C_{2}H_{2} and argon by broadband rotational spectroscopy revealed the existence of a T-shaped complex of hitherto unknown origin. Empirical tests revealed that this complex requires the presence of C_{2}H_{2} and Ag within the gas sample. While the intensity of the associated transitions are enhanced by the presence of SF_{6}, theoretical calculations and empirical tests implied that the identified complex is H_{2}C_{2}\\cdotsAgCCH rather than the original target of the experiment, H_{2}C_{2}\\cdotsAgF. This deduction is now supported by evidence acquired through experiments exploiting ^{13}C-enriched isotopic samples. Transitions have been assigned for the H_{2}^{13}C_{2}\\cdotsAg^{13}C^{13}CH isotopologue. Data acquired from each isotopologue allows determination of the rotational constants (B}_{0}, C}_{0}) and centrifugal distortion constant, Δ_J}. The data are consistent with a T-shaped complex in which the Ag atom of AgCCH binds to electrons within the {π}-orbitals of ethyne. Preliminary determinations of bond lengths will be presented. Experiments are in progress to measure the spectra of deuterated isotopologues.

  11. JAMSTEC Compact Arctic Drifter (J-CAD): A new Generation drifting buoy to observe the Arctic Ocean

    NASA Astrophysics Data System (ADS)

    Hatakeyama, Kiyoshi; Hosono, Masuo; Shimada, Koji; Kikuchi, Takashi; Nishino, Shigeto

    The Arctic Ocean is one of the most sensitive regions to the earth environment changes. Japan Marine Science and Technology Center developed a new drift buoy to observe the Arctic Ocean. The name of the buoy is J-CAD (JAMSTEC Compact Arctic Drifter). From 1991 to 1993, JAMSTEC developed Ice-Ocean Environmental Buoy (IOEB) as a buoy to observe the Arctic Ocean in cooperation with Woods Hole Oceanographic Institution. The J-CAD is the buoy, which adopted the latest technology based on the knowledge and experience of IOEB development. The J-CAD was designed and developed by JAMSTEC and made by a Canadian Company MetOcean. JAMSTEC did design and development, and a Canadian company Met-Ocean made the J-CAD. It acquires meteorological and oceanographic data of the Arctic Ocean, and transmits the data that it measured via satellite. It dose also store the data inside its memory. An Inductive Modem system, which was developed by Sea-Bird Electronics, Inc. in the United States, was adopted in the underwater transmission system that data on each ocean sensor were collected. An ORBCOMM communication system was adopted for the satellite data transmission. J-CAD-1 was installed at 89°41'N 130°20'W on April 24, 2000, and the observation was started. August 1st was the day when 100 days have passed since the J-CAD-1 was installed on the North Pole. And now, the distance J-CAD-1 has covered exceeds 400 km, and it has transmitted data more than 500 k byte. A part of the data is introduced to the public in the homepage (http://w3.jamstec.go.jp: 8338) of the Arctic research group of JAMSTEC.

  12. The First Observation of Memory Effects in the InfraRed (FT-IR) Measurements: Do Successive Measurements Remember Each Other?

    PubMed Central

    Nigmatullin, Raoul R.; Osokin, Sergey I.; Baleanu, Dumitru; Al-Amri, Sawsan; Azam, Ameer; Memic, Adnan

    2014-01-01

    Over the past couple of decades there have been major advances in the field of nanoscience and nanotechnology. Many applications have sprouted from these fields of research. It is essential, given the scale of the materials, to attain accurate, valid and reproducible measurements. Material properties have shown to be a function of their size and composition. Physiochemical properties of the nanomaterials can significantly alter material behavior compared to bulk counterparts. For example, metal oxide nanoparticles have found broad applications ranging from photo-catalysis to antibacterial agents. In our study, we synthesized CuO nanoparticles using well established sol-gel based methods with varying levels of Ni doping. However, upon analysis of measured infrared data, we discovered the presence of quasi-periodic (QP) processes. Such processes have previously been reported to be tightly associated with measurement memory effects. We were able to detect the desired QP process in these measurements from three highly accurate repetitive experiments performed on each Ni (1–7%) doped CuO sample. In other words, successive measurements performed in a rather short period of time remember each other at least inside a group of neighboring measurements. PMID:24722337

  13. SYSTEMATIC MOTION OF FINE-SCALE JETS AND SUCCESSIVE RECONNECTION IN SOLAR CHROMOSPHERIC ANEMONE JET OBSERVED WITH THE SOLAR OPTICAL TELESCOPE/HINODE

    SciTech Connect

    Singh, K. A. P.; Nishida, K.; Shibata, K.; Isobe, H.

    2012-11-20

    The Solar Optical Telescope (SOT) on board Hinode allows observations with high spatiotemporal resolution and stable image quality. A {lambda}-shaped chromospheric anemone jet was observed in high resolution with SOT/Hinode. We found that several fine-scale jets were launched from one end of the footpoint to the other. These fine-scale jets ({approx}1.5-2.5 Mm) gradually move from one end of the footpoint to the other and finally merge into a single jet. This process occurs recurrently, and as time progresses the jet activity becomes more and more violent. The time evolution of the region below the jet in Ca II H filtergram images taken with SOT shows that various parts (or knots) appear at different positions. These bright knots gradually merge into each other during the maximum phase. The systematic motion of the fine-scale jets is observed when different knots merge into each other. Such morphology would arise due to the emergence of a three-dimensional twisted flux rope in which the axial component (or the guide field) appears in the later stages of the flux rope emergence. The partial appearance of the knots could be due to the azimuthal magnetic field that appears during the early stage of the flux rope emergence. If the guide field is strong and reconnection occurs between the emerging flux rope and an ambient magnetic field, this could explain the typical feature of systematic motion in chromospheric anemone jets.

  14. Systematic Motion of Fine-scale Jets and Successive Reconnection in Solar Chromospheric Anemone Jet Observed with the Solar Optical Telescope/Hinode

    NASA Astrophysics Data System (ADS)

    Singh, K. A. P.; Isobe, H.; Nishida, K.; Shibata, K.

    2012-11-01

    The Solar Optical Telescope (SOT) on board Hinode allows observations with high spatiotemporal resolution and stable image quality. A λ-shaped chromospheric anemone jet was observed in high resolution with SOT/Hinode. We found that several fine-scale jets were launched from one end of the footpoint to the other. These fine-scale jets (~1.5-2.5 Mm) gradually move from one end of the footpoint to the other and finally merge into a single jet. This process occurs recurrently, and as time progresses the jet activity becomes more and more violent. The time evolution of the region below the jet in Ca II H filtergram images taken with SOT shows that various parts (or knots) appear at different positions. These bright knots gradually merge into each other during the maximum phase. The systematic motion of the fine-scale jets is observed when different knots merge into each other. Such morphology would arise due to the emergence of a three-dimensional twisted flux rope in which the axial component (or the guide field) appears in the later stages of the flux rope emergence. The partial appearance of the knots could be due to the azimuthal magnetic field that appears during the early stage of the flux rope emergence. If the guide field is strong and reconnection occurs between the emerging flux rope and an ambient magnetic field, this could explain the typical feature of systematic motion in chromospheric anemone jets.

  15. Success Counseling.

    ERIC Educational Resources Information Center

    Boffey, D. Barnes; Boffey, David M.

    1993-01-01

    Describes success counseling, a counseling approach based on the principles of William Glasser's control theory and reality therapy that helps campers examine their wants and needs, evaluate their own behaviors, and see the connections between behavior and the ability to meet basic needs for love, power, fun, and freedom. Provides examples of…

  16. Project Success.

    ERIC Educational Resources Information Center

    Meredith, Larry D.

    Project Success consists of after-school, weekend, and summer educational programs geared toward minority and disadvantaged students to increase their numbers seeking postsecondary education from the Meadville, Pennsylvania area. The project is funded primarily through the Edinboro University of Pennsylvania, whose administration is committed to…

  17. Project Success.

    ERIC Educational Resources Information Center

    Meredith, Larry D.

    Project Success consists of after-school, weekend, and summer educational programs geared toward minority and disadvantaged students to increase their numbers seeking postsecondary education from the Meadville, Pennsylvania area. The project is funded primarily through the Edinboro University of Pennsylvania, whose administration is committed to…

  18. Success Counseling.

    ERIC Educational Resources Information Center

    Boffey, D. Barnes; Boffey, David M.

    1993-01-01

    Describes success counseling, a counseling approach based on the principles of William Glasser's control theory and reality therapy that helps campers examine their wants and needs, evaluate their own behaviors, and see the connections between behavior and the ability to meet basic needs for love, power, fun, and freedom. Provides examples of…

  19. International VLBI Service for Geodesy and Astrometry - Delivering high-quality products and embarking on observations of the next generation

    NASA Astrophysics Data System (ADS)

    Nothnagel, A.; Artz, T.; Behrend, D.; Malkin, Z.

    2016-09-01

    The International VLBI Service for Geodesy and Astrometry (IVS) regularly produces high-quality Earth orientation parameters from observing sessions employing extensive networks or individual baselines. The master schedule is designed according to the telescope days committed by the stations and by the need for dense sampling of the Earth orientation parameters (EOP). In the pre-2011 era, the network constellations with their number of telescopes participating were limited by the playback and baseline capabilities of the hardware (Mark4) correlators. This limitation was overcome by the advent of software correlators, which can now accommodate many more playback units in a flexible configuration. In this paper, we describe the current operations of the IVS with special emphasis on the quality of the polar motion results since these are the only EOP components which can be validated against independent benchmarks. The polar motion results provided by the IVS have improved continuously over the years, now providing an agreement with IGS results at the level of 20-25 μ as in a WRMS sense. At the end of the paper, an outlook is given for the realization of the VLBI Global Observing System.

  20. International VLBI Service for Geodesy and Astrometry. Delivering high-quality products and embarking on observations of the next generation

    NASA Astrophysics Data System (ADS)

    Nothnagel, A.; Artz, T.; Behrend, D.; Malkin, Z.

    2017-07-01

    The International VLBI Service for Geodesy and Astrometry (IVS) regularly produces high-quality Earth orientation parameters from observing sessions employing extensive networks or individual baselines. The master schedule is designed according to the telescope days committed by the stations and by the need for dense sampling of the Earth orientation parameters (EOP). In the pre-2011 era, the network constellations with their number of telescopes participating were limited by the playback and baseline capabilities of the hardware (Mark4) correlators. This limitation was overcome by the advent of software correlators, which can now accommodate many more playback units in a flexible configuration. In this paper, we describe the current operations of the IVS with special emphasis on the quality of the polar motion results since these are the only EOP components which can be validated against independent benchmarks. The polar motion results provided by the IVS have improved continuously over the years, now providing an agreement with IGS results at the level of 20-25 μas in a WRMS sense. At the end of the paper, an outlook is given for the realization of the VLBI Global Observing System.

  1. The Success of Thread-embedding Therapy in Generating Hair Re-growth in Mice Points to Its Possibly Having a Similar Effect in Humans

    PubMed Central

    Shin, Hyun Jong; Lee, Dong-Jin; Kwon, Kang; Seo, Hyung-Sik; Jeong, Han-Sol; Lee, Ji-Yeon; Ha, Ki-Tae; Lee, Chang-Hyun; Jang, Yong-Suk; Lee, Byung-Wook; Kim, Byung Joo; Jung, Myeong-Ho

    2015-01-01

    Objectives: Recently, thread-embedding therapy (TET) has been widely applied in Korean medicine for cosmetic purposes such as reducing skin wrinkles. An inserted thread was reported to have induced continuous stimulation, followed by support for connective tissue regeneration. However, the potential role of TET in hairgrowth has not yet been reported. Methods: We designed this study to evaluate whether TET has a hair-growth-promoting effect. C57 black 6 (C57BL/6) mice were divided into three groups: normal saline-treated, minoxidil-treated, and thread-embedded groups. Normal saline or 5% minoxidil was topically sprayed on the dorsal skin of the mice once a day for 16 days. Medical threads were embedded into the dorsal skin of the mice in a single application. Hair growth activity was evaluated by using dermoscopic and microscopic observations. Sections of the dorsal skin were stained with hematoxylin and eosin. Expressions of bromodeoxyuridine (BrdU), proliferating cell nuclear antigen (PCNA), fibroblast growth factor-7 (FGF-7), and fibroblast growth factor-5 (FGF-5) were detected by using immunohistochemical staining. A reverse transcription-polymerase chain reaction (RT-PCR) analysis was adopted to measure the messenger RNA (mRNA) expressions of FGF-7 and FGF-5. Results: TET enhanced anagen development in the hair follicles of C57BL/6 mice. The expressions of BrdU and PCNA, both of which imply active cellular proliferation, were increased by using TET. Moreover, TET increased the expression of FGF-7, an anagen-inducing growth factor, while decreasing the expression of FGF-5, an anagen-cessation growth factor, both at the protein and the mRNA levels. Conclusion: TET enhanced hair re-growth in C57BL/6 mice. TET regulated the expressions of anagen-associated growth factors and activated the proliferation of hair follicular cells in depilated skin lesions. Considering its long-lasting effect, TET may be a good alternative therapeutic for the treatment of alopecia

  2. Observations on the removal of brood inoculated with Tropilaelaps mercedesae (Acari: Laelapidae) and the mite's reproductive success in Apis mellifera colonies.

    PubMed

    Khongphinitbunjong, Kitiphong; de Guzman, Lilia I; Buawangpong, Ninat; Rinderer, Thomas E; Frake, Amanda M; Chantawannakul, Panuwan

    2014-01-01

    This study assessed the response of Apis mellifera to brood deliberately infested with Tropilaelaps mercedesae. The reproductive success of T. mercedesae in mite-inoculated and naturally infested brood was also compared. The presence of T. mercedesae inside brood cells significantly affected brood removal. Thai A. mellifera removed 52.6 ± 8.2 % of the brood inoculated with T. mercedesae as compared to 17.2 ± 1.8 and 5.7 ± 1.1 % removal rates for the groups of brood with their cell cappings opened and closed without mite inoculation and the control brood (undisturbed, no mite inoculation), respectively. Brood removal peaked during the second and third days post inoculation when test brood was at the prepupal stage. Overall, non-reproduction (NR) of foundress T. mercedesae was high. However, when NR was measured based on the criteria used for Varroa, the naturally infested pupae (NIP) supported the highest NR (92.8 %). Newly sealed larvae inoculated with Tropilaelaps collected from newly sealed larvae (NSL) had 78.2 % NR and those inoculated with Tropilaelaps collected from tan-bodied pupae (TBP) had 76.8 % NR. Since Tropilaelaps is known to have a short development period and nearly all progeny reach adulthood by the time of host emergence, we also used two Tropilaelaps-specific criteria to determine NR. Foundresses that did not produce progeny and those that produced only one progeny were considered NR. Using these two criteria, NR decreased tremendously but showed similar trends with means of 65, 40 and 33 % for NIP, NSL and TBP, respectively. High NR in the NIP group may indicate increased hygienic behavior in Thai A. mellifera colonies. The removal of infested prepupae or tan-bodied pupae will likely decrease the reproductive potential of Tropilaelaps. Our study suggests that brood removal may be one of the resistance mechanisms towards T. mercedesae by naturally adapted Thai A. mellifera.

  3. Surface defects generated by extrinsic origins on 4H-SiC epitaxial-wafers observed by scanning electron microscopy.

    PubMed

    Matsuhata, Hirofumi; Sugiyama, Naoyuki; Chen, Bin; Yamashita, Tamotsu; Hatakeyama, Tetsuo; Sekiguchi, Takashi

    2017-04-01

    Surface defects on 4H-SiC wafers with an epitaxial layer grown by chemical vapor deposition (CVD) were observed using scanning electron microscopy (SEM). Commercially available epitaxial-wafers with four or eight deg-off surface from the [0001] toward the [112¯0] directions were used for this experiment. 3C-SiC particles, triangular-defects, comets, obtuse-triangular-shaped-defects and micro-holes were identified in the SEM images. This paper can be considered as a catalog of SEM images and descriptions of various surface defects for 4H-SiC wafers with a CVD-grown epilayer. © The Author 2016. Published by Oxford University Press on behalf of The Japanese Society of Microscopy. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  4. Observation of Arabian and Saharan Dust in Cyprus with a New Generation of the Smart Raman Lidar Polly

    NASA Astrophysics Data System (ADS)

    Engelmann, Ronny; Ansmann, Albert; Bühl, Johannes; Heese, Birgit; Baars, Holger; Althausen, Dietrich; Marinou, Eleni; Amiridis, Vassilis; Mamouri, Rodanthi-Elisavet; Vrekoussis, Mihalis

    2016-06-01

    The atmospheric science community demands for autonomous and quality-assured vertically resolved measurements of aerosol and cloud properties. Aiming this goal, TROPOS developed the fully automated multiwavelength polarization Raman lidar Polly since over 10 years [1, 2]. In cooperation with different partner research institutes the system was improved continuously. Our latest lidar developments include aside the "3+2" measurements also a near-range receiver to measure aerosol extinction and backscatter down to 120 m above the lidar, a water-vapor channel, and measurements of the linear depolarization at two wavelengths. The latest system was built in cooperation with the National Observatory of Athens (NOA). Its first campaign however was performed at the Cyprus Institute of Nicosia from March to April 2015, aiming specifically at the observation of ice nuclei with in-situ and lidar remote sensing techniques in the framework of BACCHUS [3, 4].

  5. Phase matching considerations in second harmonic generation from tissues: Effects on emission directionality, conversion efficiency and observed morphology

    NASA Astrophysics Data System (ADS)

    LaComb, Ronald; Nadiarnykh, Oleg; Townsend, Sallie S.; Campagnola, Paul J.

    2008-04-01

    We present a heuristic treatment which relates SHG image intensities, signal directionality, and observed morphology to the physical structure of collagen and cellulose fibrillar tissues. The SHG creation model is based upon relaxed phase matching conditions which account for dispersion, randomness, and axial momentum contributions from the media, and includes a mathematical treatment which relates SHG conversion efficiency to fibril diameter and packing through the inclusion of potential intensity amplification resultant from quasi-phase matching (QPM). A direct consequence of this theory is that SHG in biological tissues is not strictly a coherent process, and that the forward directed SHG has a longer coherence length than the backward component, Through this treatment, we show that the emission directionality and also conversion efficiency do not arise solely from the fibril size but also depend on packing density and order of the inter-fibril structure. We demonstrate these principles in comparing the SHG response in normal and Osteogenesis Imperfecta (OI) skin. We show that the observed directionality and decreased relative intensity in the diseased state is consistent with phase matching conditions arising from the decreased fibril size and more random assembly. We further use this theory to explain the differences in morphology seen in forward and backward collected SHG in fibrillar tissues (e.g., collagenous and cellulosic). Specifically, we attribute segmented appearance to destructive interference between small fibrils separated by less than the coherence length. We suggest the approach based on relaxed phasematching conditions is general in predicting the SHG response in tissues and may be broadly applicable in interpreting the SHG contrast for diagnostic applications.

  6. A ‘NanoSuit’ surface shield successfully protects organisms in high vacuum: observations on living organisms in an FE-SEM

    PubMed Central

    Takaku, Yasuharu; Suzuki, Hiroshi; Ohta, Isao; Tsutsui, Takami; Matsumoto, Haruko; Shimomura, Masatsugu; Hariyama, Takahiko

    2015-01-01

    Although extremely useful for a wide range of investigations, the field emission scanning electron microscope (FE-SEM) has not allowed researchers to observe living organisms. However, we have recently reported that a simple surface modification consisting of a thin extra layer, termed ‘NanoSuit’, can keep organisms alive in the high vacuum (10−5 to 10−7 Pa) of the SEM. This paper further explores the protective properties of the NanoSuit surface-shield. We found that a NanoSuit formed with the optimum concentration of Tween 20 faithfully preserves the integrity of an organism's surface without interfering with SEM imaging. We also found that electrostatic charging was absent as long as the organisms were alive, even if they had not been coated with electrically conducting materials. This result suggests that living organisms possess their own electrical conductors and/or rely on certain properties of the surface to inhibit charging. The NanoSuit seems to prolong the charge-free condition and increase survival time under vacuum. These findings should encourage the development of more sophisticated observation methods for studying living organisms in an FE-SEM. PMID:25631998

  7. Successful integration efforts in water quality from the integrated Ocean Observing System Regional Associations and the National Water Quality Monitoring Network

    USGS Publications Warehouse

    Ragsdale, R.; Vowinkel, E.; Porter, D.; Hamilton, P.; Morrison, R.; Kohut, J.; Connell, B.; Kelsey, H.; Trowbridge, P.

    2011-01-01

    The Integrated Ocean Observing System (IOOS??) Regional Associations and Interagency Partners hosted a water quality workshop in January 2010 to discuss issues of nutrient enrichment and dissolved oxygen depletion (hypoxia), harmful algal blooms (HABs), and beach water quality. In 2007, the National Water Quality Monitoring Council piloted demonstration projects as part of the National Water Quality Monitoring Network (Network) for U.S. Coastal Waters and their Tributaries in three IOOS Regional Associations, and these projects are ongoing. Examples of integrated science-based solutions to water quality issues of major concern from the IOOS regions and Network demonstration projects are explored in this article. These examples illustrate instances where management decisions have benefited from decision-support tools that make use of interoperable data. Gaps, challenges, and outcomes are identified, and a proposal is made for future work toward a multiregional water quality project for beach water quality.

  8. Direct Spectroscopic Observation of the Structural Origin of Peroxide Generation from Co-Based Pyrolyzed Porphyrins for ORR Applications

    SciTech Connect

    Ziegelbauer,J.; Olson, T.; Pylypenko, S.; Alamgir, F.; Jaye, C.; Atanassov, P.; Mukerjee, S.

    2008-01-01

    Pyrolyzed transition metal based porphyrins present an attractive alternative to state of the art Pt-based electrocatalysts for fuel cell applications based on their comparatively low cost. Unfortunately, the large array of precursors and synthetic strategies has led to considerable ambiguity regarding the specific structure/property relationships that give rise to their activity for oxygen reduction. Specifically, considerable debate exists in actual chemical structure of the pyrolyzed reaction centers, and their relationship to membrane-damaging peroxide yield. In this manuscript a comprehensive electrochemical and spectroscopic study of pyrolyzed CoTMPP produced via a self-templating process is presented. The resulting electrocatalysts are not carbon-supported, but are highly porous self-supported pyropolymers. Rotating ring disk electrode measurements showed that the materials pyrolyzed at 700 C exhibited the highest performance, whereas pyrolysis at 800 C resulted in a significant increase in the peroxide yield. X-ray photoelectron spectroscopy and Co L and K edge extended X-ray absorption fine structure (EXAFS) studies confirm that the majority of the Co-N4 active site has broken down to Co-N2 at 800 C. Application of ?{mu} analysis (an X-ray absorption near-edge structure difference technique) to the in situ Co K edge EXAFS data allowed for direct spectroscopic observation of the geometry of Oads on the pyropolymer active sites. The specific geometrical adsorption of molecular oxygen with respect to the plane of the Co-Nx moieties highly influences the oxygen reduction reaction pathway. The application of the ?{mu} technique to other transition metal based macrocycle electrocatalyst systems is expected to provide similarly detailed information.

  9. Relationships between atmospheric circulation indices and rainfall in Northern Algeria and comparison of observed and RCM-generated rainfall

    NASA Astrophysics Data System (ADS)

    Taibi, S.; Meddi, M.; Mahé, G.; Assani, A.

    2017-01-01

    This work aims, as a first step, to analyze rainfall variability in Northern Algeria, in particular extreme events, during the period from 1940 to 2010. Analysis of annual rainfall shows that stations in the northwest record a significant decrease in rainfall since the 1970s. Frequencies of rainy days for each percentile (5th, 10th, 25th, 50th, 75th, 90th, 95th, and 99th) and each rainfall interval class (1-5, 5-10, 10-20, 20-50, and ≥50 mm) do not show a significant change in the evolution of daily rainfall. The Tenes station is the only one to show a significant decrease in the frequency of rainy days up to the 75th percentile and for the 10-20-mm interval class. There is no significant change in the temporal evolution of extreme events in the 90th, 95th, and 99th percentiles. The relationships between rainfall variability and general atmospheric circulation indices for interannual and extreme event variability are moderately influenced by the El Niño-Southern Oscillation and Mediterranean Oscillation. Significant correlations are observed between the Southern Oscillation Index and annual rainfall in the northwestern part of the study area, which is likely linked with the decrease in rainfall in this region. Seasonal rainfall in Northern Algeria is affected by the Mediterranean Oscillation and North Atlantic Oscillation in the west. The ENSEMBLES regional climate models (RCMs) are assessed using the bias method to test their ability to reproduce rainfall variability at different time scales. The Centre National de Recherches Météorologiques (CNRM), Czech Hydrometeorological Institute (CHMI), Eidgenössische Technische Hochschule Zürich (ETHZ), and Forschungszentrum Geesthacht (GKSS) models yield the least biased results.

  10. Next generation sensing platforms for extended deployments in large-scale, multidisciplinary, adaptive sampling and observational networks

    NASA Astrophysics Data System (ADS)

    Cross, J. N.; Meinig, C.; Mordy, C. W.; Lawrence-Slavas, N.; Cokelet, E. D.; Jenkins, R.; Tabisola, H. M.; Stabeno, P. J.

    2016-12-01

    , including reconnaissance for annual fisheries and marine mammal surveys; better linkages between sustained observing platforms; and adaptive deployments that can easily target anomalies as they arise.

  11. Rekindling Success

    ERIC Educational Resources Information Center

    Sanders, April

    2008-01-01

    What can a family, a school, or even a community do to re-engage students who have fallen by the wayside and thus become part of an unproductive, uninspired, and burden-heavy generation? One option, described in this article, is a Star Academy, comprised of several parts that cohesively function as a whole. To enable this synergy of education and…

  12. Errors generated by a point-of-care CD4+ T-lymphocyte analyser: a retrospective observational study in nine countries

    PubMed Central

    Metcalf, Carol; Piriou, Erwan; Gueguen, Monique; Maman, David; Chaillet, Pascale; Cox, Vivian; Rumaney, Maryam B; Tunggal, Syanness; Kosack, Cara; Roberts, Teri

    2015-01-01

    Abstract Objective To estimate the proportion of invalid results generated by a CD4+ T-lymphocyte analyser used by Médecins Sans Frontières (MSF) in field projects and identify factors associated with invalid results. Methods We collated 25 616 CD4+ T-lymphocyte test results from 39 sites in nine countries for the years 2011 to 2013. Information about the setting, user, training, sampling technique and device repair history were obtained by questionnaire. The analyser performs a series of checks to ensure that all steps of the analysis are completed successfully; if not, an invalid result is reported. We calculated the proportion of invalid results by device and by operator. Regression analyses were used to investigate factors associated with invalid results. Findings There were 3354 invalid test results (13.1%) across 39 sites, for 58 Alere PimaTM devices and 180 operators. The median proportion of errors per device and operator was 12.7% (interquartile range, IQR: 10.3–19.9) and 12.1% (IQR: 7.1–19.2), respectively. The proportion of invalid results varied widely by country, setting, user and device. Errors were not associated with settings, user experience or the number of users per device. Tests performed on capillary blood samples were significantly less likely to generate errors compared to venous whole blood. Conclusion The Alere Pima CD4+ analyser generated a high proportion of invalid test results, across different countries, settings and users. Most error codes could be attributed to the operator, but the exact causes proved difficult to identify. Invalid results need to be factored into the implementation and operational costs of routine CD4+ T-lymphocyte testing. PMID:26478626

  13. Observation of beat oscillation generation by coupled waves associated with parametric decay during radio frequency wave heating of a spherical tokamak plasma.

    PubMed

    Nagashima, Yoshihiko; Oosako, Takuya; Takase, Yuichi; Ejiri, Akira; Watanabe, Osamu; Kobayashi, Hiroaki; Adachi, Yuuki; Tojo, Hiroshi; Yamaguchi, Takashi; Kurashina, Hiroki; Yamada, Kotaro; An, Byung Il; Kasahara, Hiroshi; Shimpo, Fujio; Kumazawa, Ryuhei; Hayashi, Hiroyuki; Matsuzawa, Haduki; Hiratsuka, Junichi; Hanashima, Kentaro; Kakuda, Hidetoshi; Sakamoto, Takuya; Wakatsuki, Takuma

    2010-06-18

    We present an observation of beat oscillation generation by coupled modes associated with parametric decay instability (PDI) during radio frequency (rf) wave heating experiments on the Tokyo Spherical Tokamak-2. Nearly identical PDI spectra, which are characterized by the coexistence of the rf pump wave, the lower-sideband wave, and the low-frequency oscillation in the ion-cyclotron range of frequency, are observed at various locations in the edge plasma. A bispectral power analysis was used to experimentally discriminate beat oscillation from the resonant mode for the first time. The pump and lower-sideband waves have resonant mode components, while the low-frequency oscillation is exclusively excited by nonlinear coupling of the pump and lower-sideband waves. Newly discovered nonlocal transport channels in spectral space and in real space via PDI are described.

  14. Fast and Efficient Fragment-Based Lead Generation by Fully Automated Processing and Analysis of Ligand-Observed NMR Binding Data.

    PubMed

    Peng, Chen; Frommlet, Alexandra; Perez, Manuel; Cobas, Carlos; Blechschmidt, Anke; Dominguez, Santiago; Lingel, Andreas

    2016-04-14

    NMR binding assays are routinely applied in hit finding and validation during early stages of drug discovery, particularly for fragment-based lead generation. To this end, compound libraries are screened by ligand-observed NMR experiments such as STD, T1ρ, and CPMG to identify molecules interacting with a target. The analysis of a high number of complex spectra is performed largely manually and therefore represents a limiting step in hit generation campaigns. Here we report a novel integrated computational procedure that processes and analyzes ligand-observed proton and fluorine NMR binding data in a fully automated fashion. A performance evaluation comparing automated and manual analysis results on (19)F- and (1)H-detected data sets shows that the program delivers robust, high-confidence hit lists in a fraction of the time needed for manual analysis and greatly facilitates visual inspection of the associated NMR spectra. These features enable considerably higher throughput, the assessment of larger libraries, and shorter turn-around times.

  15. Lower hybrid frequency range waves generated by ion polarization drift due to electromagnetic ion cyclotron waves: Analysis of an event observed by the Van Allen Probe B

    NASA Astrophysics Data System (ADS)

    Khazanov, G. V.; Boardsen, S.; Krivorutsky, E. N.; Engebretson, M. J.; Sibeck, D.; Chen, S.; Breneman, A.

    2017-01-01

    We analyze a wave event that occurred near noon between 07:03 and 07:08 UT on 23 February 2014 detected by the Van Allen Probes B spacecraft, where waves in the lower hybrid frequency range (LHFR) and electromagnetic ion cyclotron (EMIC) waves are observed to be highly correlated, with Pearson correlation coefficient of 0.86. We assume that the correlation is the result of LHFR wave generation by the ions' polarization drift in the electric field of the EMIC waves. To check this assumption the drift velocities of electrons and H+, He+, and O+ ions in the measured EMIC wave electric field were modeled. Then the LHFR wave linear instantaneous growth rates for plasma with these changing drift velocities and different plasma compositions were calculated. The time distribution of these growth rates, their frequency distribution, and the frequency dependence of the ratio of the LHFR wave power spectral density (PSD) parallel and perpendicular to the ambient magnetic field to the total PSD were found. These characteristics of the growth rates were compared with the corresponding characteristics of the observed LHFR activity. Reasonable agreement between these features and the strong correlation between EMIC and LHFR energy densities support the assumption that the LHFR wave generation can be caused by the ions' polarization drift in the electric field of an EMIC wave.

  16. Observation of the generation and evolution of long-lived runaway electron beams during major disruptions in the HuanLiuqi-2A tokamak

    NASA Astrophysics Data System (ADS)

    Zhang, Y. P.; Liu, Yi; Yuan, G. L.; Isobe, M.; Chen, Z. Y.; Cheng, J.; Ji, X. Q.; Song, X. M.; Yang, J. W.; Song, X. Y.; Li, X.; Deng, W.; Li, Y. G.; Xu, Y.; Sun, T. F.; Ding, X. T.; Yan, L. W.; Yang, Q. W.; Duan, X. R.; Liu, Y.; HL-2A Team

    2012-03-01

    In an experimental study of the runaway electron generation during major disruptions in the HuanLiuqi-2A (commonly referred to as HL-2A) [L. W. Yan, Nucl. Fusion 51, 094016 (2011)] tokamak, detailed time and space resolved x-ray images of the long-lived runaway electron beam in flight have been observed and these allow a detailed analysis of the generation and evolution of the disruption produced runaway electron beam in a major disruption, where the conversion efficiency of pre-disruption plasma current into runaway current is up to 55% on HL-2A tokamak. Moreover, a delay of about 7 ms between the start of the disruption and the formation of runaway electron beam has been found. With the aid of the Equilibrium FIT (EFIT) code, magnetic configuration reconstruction has made possible a detailed observation of the magnetic flux geometry evolution during major disruptions. The EFIT magnetic configuration reconstructions show that the delay is due to the transient strong deformation of the magnetic configuration in the initial stage of the current quench, which may provide a possibility of suppressing or mitigating the runaway electron beam during this period by massive gas injection or other methods.

  17. Possible generation mechanisms for Pc1 pearl structures in the ionosphere based on 6 years of ground observations in Canada, Russia, and Japan

    NASA Astrophysics Data System (ADS)

    Jun, Chae-Woo; Shiokawa, Kazuo; Connors, Martin; Schofield, Ian; Poddelsky, Igor; Shevtsov, Boris

    2016-05-01

    We investigate pearl structures (amplitude modulations) of Pc1 pulsations simultaneously observed at Athabasca (ATH, 54.7°N, 246.7°E, L = 4.3) in Canada, Magadan (MGD, 60.1°N, 150.7°E, L = 2.6) in Russia, and Moshiri (MOS, 44.4°N, 142.3°E, L = 1.5) in Japan. From 6 years of ground observations, from 2008 to 2013, we selected 84 Pc1 events observed simultaneously at the longitudinally separated stations (ATH and MGD) and 370 events observed at the latitudinally separated stations (MGD and MOS), all with high coherence (>0.7) of Pc1 waveforms. We calculated the cross-correlation coefficient (similarity: r) for the Pc1 pearl structures and found that more than half of the events in both pairs had low similarity (r < 0.7), indicating that most Pc1 waves exhibit different pearl structures at different stations. We found that high-similarity Pc1 pearl structures (r > 0.7) at the longitudinally separated stations are concentrated from 6 to 15 UT when both stations are in the nighttime. The similarity of Pc1 pearl structures tends to show a negative correlation with the standard deviation of the polarization angle in both pairs. The observed repetition period of Pc1 pearl structures has a clear positive correlation with the repetition period estimated from Pc1 bandwidth by assuming beating of different frequencies. From these results, we suggest that ionospheric beating effect could be a dominant process for the generation of Pc1 pearl structures. Beating processes in the ionosphere with a spatially distributed ionospheric source can cause the different shapes of Pc1 pearl structures at different observation points during ionospheric duct propagation.

  18. Bangladesh becomes "success story".

    PubMed

    1999-01-01

    The State Minister for Health and Family of Bangladesh, Dr. Mohammed Amanullah, highlighted some of the successes being achieved by his country in lowering fertility and improving the lives of the people since the 1994 International Conference on Population and Development. Some of these successes include practical measures to eliminate violence against women; introduction of a quota for women in public sector employment; and launching of the Health and Population Sector Program to provide a one-stop, full range of essential reproductive health, family planning and child health services through an integrated delivery mechanism. Moreover, the Minister informed the Forum participants that their success is attributable to many factors which include support from the government, from non-governmental organizations, civil society, mass media, religious and other community leaders, intersectoral collaboration, microcredit and income-generation activities.

  19. Observing system simulation experiments to evaluate the expected added-value of a new generation IASI satellite instrument for lower tropospheric ozone analyses and forecasts

    NASA Astrophysics Data System (ADS)

    Dauphin, Pierre; Sellitto, Pasquale; Dufour, Gaëlle; Coman, Adriana; Forêt, Gilles; Eremenko, Maxim; Cuesta, Juan; Gaubert, Benjamin; Beekmann, Matthias; Peuch, Vincent-Henri; Flaud, Jean-Marie

    2013-04-01

    Tropospheric ozone can adversely impact human health, climate and the ecosystem. Monitoring and legislation are implemented to regulate its concentrations. Air quality (AQ) monitoring from space starts to be regarded as a useful tool to complement with in situ measurements and regional chemical transport models (rCTM) to draw a more comprehensive picture of pollution processes. Important progresses in the field of tropospheric ozone sounding from space have been accomplished during the last decade, especially with thermal infrared (TIR) space-borne instruments. It is now possible to observe tropospheric ozone concentrations from space with a reasonable accuracy. However, limitations remain with the current observation systems in particular to observe ozone in the lowermost troposphere. IASI-NG, that will be part of the EPS-SG (EUMETSAT Polar System-Second Generation) programme, is expected to improve the observation capabilities of AQ in terms of ozone in the lower troposphere. Observing system simulation experiments (OSSEs) are powerful tools to quantify the added-value of future missions. An OSSE is composed of different elements: (1) one reference atmosphere, usually given by model simulations (the Nature Run); (2) an optimized observation simulator, providing the pseudo-observations; (3) an independent description of the atmosphere (the Control Run); (4) an assimilation system, providing the Assimilation Run. We conduct relative OSSEs, aimed at comparing the contribution of one possible configuration of IASI-NG (IASI-NG/IRS2) and the present IASI instrument, used as a baseline. The spectral resolution and the radiometric noise in the ozone spectral region, for IASI-NG/IRS2, are twice better than for IASI. IASI-NG/IRS2 pseudo-observations are processed using a comprehensive simulator based on the radiative transfer model KOPRA and the KOPRAFIT inversion module. The Nature Run is given by the CTM MOCAGE model, the Control Run is produced with the CHIMERE CTM, and

  20. Successful ageing for psychiatrists.

    PubMed

    Peisah, Carmelle

    2016-04-01

    This paper aims to explore the concept and determinants of successful ageing as they apply to psychiatrists as a group, and as they can be applied specifically to individuals. Successful ageing is a heterogeneous, inclusive concept that is subjectively defined. No longer constrained by the notion of "super-ageing", successful ageing can still be achieved in the face of physical and/or mental illness. Accordingly, it remains within the reach of most of us. It can, and should be, person-specific and individually defined, specific to one's bio-psycho-social and occupational circumstances, and importantly, reserves. Successful professional ageing is predicated upon insight into signature strengths, with selection of realistic goal setting and substitution of new goals, given the dynamic nature of these constructs as we age. Other essential elements are generativity and self-care. Given that insight is key, taking a regular stock or inventory of our reserves across bio-psycho-social domains might be helpful. Importantly, for successful ageing, this needs to be suitably matched to the professional task and load. This lends itself to a renewable personal ageing plan, which should be systemically adopted with routine expectations of self-care and professional responsibility. © The Royal Australian and New Zealand College of Psychiatrists 2015.

  1. Observation of the thermal conductivity of warm dense tungsten plasma generated by a pulsed-power discharge using laser-induced fluorescence

    NASA Astrophysics Data System (ADS)

    Sugimoto, Satoshi; Watabe, Arata; Sugimoto, Yuki; Kusano, Shingo; Takahashi, Kazumasa; Sasaki, Toru; Kikuchi, Takashi; Harada, Nob.

    2017-07-01

    To observe the transport properties of a sample of warm dense matter, we used laser-induced fluorescence to measure the thermal conductivity of tungsten plasma confined within a rigid, ruby capillary tube. We determined the density and temperature of the plasma generated by an isochoric heating device using a pulsed-power discharge. The density was determined by the initial diameter of the tungsten wire used, and the temperature was obtained by spectroscopic measurements. The temperature of the ruby capillary was obtained from its fluorescence intensity, which depends on the temperature of the outer wall. We found the thermal conductivity to be approximately 30 W/K m, thus demonstrating that the thermal conductivity of warm dense matter states can be directly evaluated using the proposed method.

  2. Enzyme system generation of singlet (/sup 1/. delta. /sub g/) molecular oxygen observed directly by 1. 0-1. 8-. mu. m luminescence spectroscopy

    SciTech Connect

    Khan, A.U.

    1983-01-01

    The observation of a strong singlet molecular oxygen luminescence emission in the ir produced in the decomposition of hydrogen peroxide by the enzymes lactoperoxidase, catalase, and chloroperoxidase is reported. A mixture of H/sub 2/O and D/sub 2/O was used as a reaction media. The luminescence emission spectra of the lactoperoxidase/H/sub 2/O/sub 2/ and chloroperoxidase/H/sub 2/O/sub 2/ were found to exhibit a single emission band at 1.28 ..mu..m for the former and three bands for the latter - a strong band at 1.30 ..mu..m and a possible weak band extending from the long-wavelength edge of the monochromator at 1.60 to 1.45 ..mu..m. The peak at 1.28 ..mu..m is absent in the catalase/H/sub 2/O/sub 2/ spectrum, but the peak at 1.64 ..mu..m is very evident. The spectra are interpreted as indicating the generation of free singlet oxygen (peak at 1.28 and 1.30 ..mu..m) in the case of the first two enzymes/H/sub 2/O/sub 2/ systems and the generation of predominately bound singlet molecular oxygen in the case of catalase/H/sub 2/O/sub 2/.

  3. A next generation Ultra-Fast Flash Observatory (UFFO-100) for IR/optical observations of the rise phase of gamma-ray bursts

    NASA Astrophysics Data System (ADS)

    Grossan, B.; Park, I. H.; Ahmad, S.; Ahn, K. B.; Barrillon, P.; Brandt, S.; Budtz-Jørgensen, C.; Castro-Tirado, A. J.; Chen, P.; Choi, H. S.; Choi, Y. J.; Connell, P.; Dagoret-Campagne, S.; De La Taille, C.; Eyles, C.; Hermann, I.; Huang, M.-H. A.; Jung, A.; Jeong, S.; Kim, J. E.; Kim, M.; Kim, S.-W.; Kim, Y. W.; Lee, J.; Lim, H.; Linder, E. V.; Liu, T.-C.; Lund, N.; Min, K. W.; Na, G. W.; Nam, J. W.; Panasyuk, M. I.; Ripa, J.; Reglero, V.; Rodrigo, J. M.; Smoot, G. F.; Suh, J. E.; Svertilov, S.; Vedenkin, N.; Wang, M.-Z.; Yashin, I.; Zhao, M. H.

    2012-09-01

    The Swift Gamma-ray Burst (GRB) observatory responds to GRB triggers with optical observations in ~ 100 s, butcannot respond faster than ~ 60 s. While some rapid-response ground-based telescopes have responded quickly, thenumber of sub-60 s detections remains small. In 2013 June, the Ultra-Fast Flash Observatory-Pathfinder is expected tobe launched on the Lomonosov spacecraft to investigate early optical GRB emission. Though possessing uniquecapability for optical rapid-response, this pathfinder mission is necessarily limited in sensitivity and event rate; here wediscuss the next generation of rapid-response space observatory instruments. We list science topics motivating ourinstruments, those that require rapid optical-IR GRB response, including: A survey of GRB rise shapes/times,measurements of optical bulk Lorentz factors, investigation of magnetic dominated (vs. non-magnetic) jet models,internal vs. external shock origin of prompt optical emission, the use of GRBs for cosmology, and dust evaporation inthe GRB environment. We also address the impacts of the characteristics of GRB observing on our instrument andobservatory design. We describe our instrument designs and choices for a next generation space observatory as a secondinstrument on a low-earth orbit spacecraft, with a 120 kg instrument mass budget. Restricted to relatively modest mass,power, and launch resources, we find that a coded mask X-ray camera with 1024 cm2 of detector area could rapidlylocate about 64 GRB triggers/year. Responding to the locations from the X-ray camera, a 30 cm aperture telescope witha beam-steering system for rapid (~ 1 s) response and a near-IR camera should detect ~ 29 GRB, given Swift GRBproperties. The additional optical camera would permit the measurement of a broadband optical-IR slope, allowingbetter characterization of the emission, and dynamic measurement of dust extinction at the source, for the first time.

  4. Observing Exoplanets with High Dispersion Coronagraphy. I. The Scientific Potential of Current and Next-generation Large Ground and Space Telescopes

    NASA Astrophysics Data System (ADS)

    Wang, Ji; Mawet, Dimitri; Ruane, Garreth; Hu, Renyu; Benneke, Björn

    2017-04-01

    Direct imaging of exoplanets presents a formidable technical challenge owing to the small angular separation and high contrast between exoplanets and their host stars. High Dispersion Coronagraphy (HDC) is a pathway to achieve unprecedented sensitivity to Earth-like planets in the habitable zone. Here, we present a framework to simulate HDC observations and data analyses. The goal of these simulations is to perform a detailed analysis of the trade-off between raw star light suppression and spectral resolution for various instrument configurations, target types, and science cases. We predict the performance of an HDC instrument at Keck observatory for characterizing directly imaged gas-giant planets in near-infrared bands. We also simulate HDC observations of an Earth-like planet using next-generation ground-based (TMT) and spaced-base telescopes (HabEx and LUVOIR). We conclude that ground-based ELTs are more suitable for HDC observations of an Earth-like planet than future space-based missions owing to the considerable difference in collecting area. For ground-based telescopes, HDC observations can detect an Earth-like planet in the habitable zone around an M-dwarf star at 10‑4 star light suppression level. Compared to the 10‑7 planet/star contrast, HDC relaxes the star light suppression requirement by a factor of 103. For space-based telescopes, detector noise will be a major limitation at spectral resolutions higher than 104. Considering detector noise and speckle chromatic noise, R = 400 (1600) is the optimal spectral resolutions for HabEx (LUVOIR). The corresponding star light suppression requirement to detect a planet with planet/star contrast = 6.1× {10}-11 is relaxed by a factor of 10 (100) for HabEx (LUVOIR).

  5. Why three generations?

    DOE PAGES

    Ibe, Masahiro; Kusenko, Alexander; Yanagida, Tsutomu T.

    2016-05-12

    Here, we discuss an anthropic explanation of why there exist three generations of fermions. If one assumes that the right-handed neutrino sector is responsible for both the matter-antimatter asymmetry and the dark matter, then anthropic selection favors three or more families of fermions. For successful leptogenesis, at least two right-handed neutrinos are needed, while the third right-handed neutrino is invoked to play the role of dark matter. The number of the right-handed neutrinos is tied to the number of generations by the anomaly constraints of the U(1)B-L gauge symmetry. Combining anthropic arguments with observational constraints, we obtain predictions for themore » X-ray observations, as well as for neutrinoless double-beta decay.« less

  6. Successful treatment of Philadelphia chromosome-positive mixed phenotype acute leukemia by appropriate alternation of second-generation tyrosine kinase inhibitors according to BCR-ABL1 mutation status.

    PubMed

    Kawajiri, Chika; Tanaka, Hiroaki; Hashimoto, Shinichiro; Takeda, Yusuke; Sakai, Shio; Takagi, Toshiyuki; Takeuchi, Masahiro; Ohwada, Chikako; Sakaida, Emiko; Shimizu, Naomi; Nakaseko, Chiaki

    2014-04-01

    Philadelphia chromosome-positive mixed phenotype acute leukemia (Ph(+)MPAL) is a rare type of acute leukemia having myeloid and lymphoid features. In the present study, we describe the successful treatment of a 71-year-old Japanese female patient with Ph(+)MPAL by the alternation of second-generation tyrosine kinase inhibitors according to BCR-ABL1 mutations. The patient survived in her third complete remission (CR) for over 4 years. In her first CR, the patient was treated with multiple-agent chemotherapy and underwent maintenance therapy with imatinib and monthly vincristine and prednisolone (VP). At the first relapse, an examination of the bone marrow revealed a transformation into acute lymphoblastic leukemia and an F317L mutation in BCR-ABL1 gene, which responded preferentially to nilotinib over dasatinib. She achieved second CR, and nilotinib with VP therapy was selected for maintenance treatment. At second relapse, BCR-ABL1 mutational analysis revealed Y253H mutation instead of F317L mutation, resulting in resistance to nilotinib. The patient achieved third CR with dasatinib and VP therapy, and maintained CR with this treatment. This suggests that appropriate alternation of TKIs may contribute to long-term survival in elderly patients with Ph(+)MPAL.

  7. Ground and CHAMP observations of field-aligned current circuits generated by lower atmospheric disturbances and expectations to the SWARM to clarify their three dimensional structure

    NASA Astrophysics Data System (ADS)

    Iyemori, Toshihiko; Nakanishi, Kunihito; Aoyama, Tadashi; Lühr, Hermann

    2014-05-01

    Acoustic gravity waves propagated to the ionosphere cause dynamo currents in the ionosphere. They divert along geomagnetic field lines of force to another hemisphere accompanying electric field and then flow in the ionosphere of another hemisphere by the electric field forming closed current circuits. The oscillating current circuits with the period of acoustic waves generate magnetic variations on the ground, and they are observed as long period geomagnetic pulsations. This effect has been detected during big earthquakes, strong typhoons, tornados etc. On a low-altitude satellite orbit, the spatial distribution (i.e., structure) of the current circuits along the satellite orbit should be detected as temporal magnetic oscillations, and the effect is confirmed by a CHAMP data analysis. On the spatial structure, in particular, in the longitudinal direction, it has been difficult to examine by a single satellite or from ground magnetic observations. The SWARM satellites will provide an unique opportunity to clarify the three dimensional structure of the field-aligned current circuits.

  8. A statistical approach for rain class evaluation using Meteosat Second Generation-Spinning Enhanced Visible and InfraRed Imager observations

    NASA Astrophysics Data System (ADS)

    Ricciardelli, E.; Cimini, D.; Di Paola, F.; Romano, F.; Viggiano, M.

    2013-11-01

    Precipitation measurements are essential for short term hydrological and long term climate studies. Operational networks of rain gauges and weather radars provide fairly accurate rain rate measurements, but they leave large areas uncovered. Because of this, satellite remote sensing is a useful tool for the detection and characterization of the raining areas in regions where this information remains missing. This study exploits the Meteosat Second Generation - Spinning Enhanced Visible and Infrared Imager (MSG-SEVIRI) observations to evaluate the rain class at high spatial and temporal resolutions. The Rain Class Evaluation from Infrared and Visible (RainCEIV) observations technique is proposed. The purpose of RainCEIV is to supply continuous monitoring of convective as well as of stratiform rainfall events. It applies a supervised classifier to the spectral and textural features of infrared and visible MSG-SEVIRI images to classify the cloudy pixels as non rainy, light to moderate rain, or heavy to very heavy rain. The technique considers in input also the water vapour channels brightness temperatures differences for the MSG-SEVIRI images acquired 15/30/45 min before the time of interest. The rainfall rates used in the training phase are obtained with the Precipitation Estimation at Microwave frequencies (PEMW), an algorithm for rain rate retrievals based on Atmospheric Microwave Sounder Unit (AMSU)-B observations. The results of RainCEIV have been validated against radar-derived rainfall measurements from the Italian Operational Weather Radar Network for some case studies limited to the Mediterranean area. The dichotomous assessment shows that RainCEIV is able to detect rainy areas with an accuracy of about 91%, a Heidke skill score of 56%, a Bias score of 1.16, and a Probability of Detection of rainy areas of 66%.

  9. Continuous generation and two-dimensional structure of equatorial plasma bubbles observed by high-density GPS receivers in Southeast Asia

    NASA Astrophysics Data System (ADS)

    Buhari, S. M.; Abdullah, M.; Hasbi, A. M.; Otsuka, Y.; Yokoyama, T.; Nishioka, M.; Tsugawa, T.

    2014-12-01

    High-density GPS receivers located in Southeast Asia (SEA) were utilized to study the two-dimensional structure of ionospheric plasma irregularities in the equatorial region. The longitudinal and latitudinal variations of tens of kilometer-scale irregularities associated with equatorial plasma bubbles (EPBs) were investigated using two-dimensional maps of the rate of total electron content change index (ROTI) from 127 GPS receivers with an average spacing of about 50-100 km. The longitudinal variations of the two-dimensional maps of GPS ROTI measurement on 5 April 2011 revealed that 16 striations of EPBs were generated continuously around the passage of the solar terminator. The separation distance between the subsequent onset locations varied from 100 to 550 km with 10 min intervals. The lifetimes of the EPBs observed by GPS ROTI measurement were between 50 min and over 7 h. The EPBs propagated 440-3000 km toward the east with velocities of 83-162 m s-1. The longitudinal variations of EPBs by GPS ROTI keogram coincided with the depletions of 630 nm emission observed using the airglow imager. Six EPBs were observed by GPS ROTI along the meridian of Equatorial Atmosphere Radar (EAR), while only three EPBs were detected by the EAR. The high-density GPS receivers in SEA have an advantage of providing time continuous descriptions of latitudinal/longitudinal variations of EPBs with both high spatial resolution and broad geographical coverage. The spatial periodicity of the EPBs could be associated with a wavelength of the quasiperiodic structures on the bottomside of the F region which initiate the Rayleigh-Taylor instability.

  10. A statistical approach for rain intensity differentiation using Meteosat Second Generation-Spinning Enhanced Visible and InfraRed Imager observations

    NASA Astrophysics Data System (ADS)

    Ricciardelli, E.; Cimini, D.; Di Paola, F.; Romano, F.; Viggiano, M.

    2014-07-01

    This study exploits the Meteosat Second Generation (MSG)-Spinning Enhanced Visible and Infrared Imager (SEVIRI) observations to evaluate the rain class at high spatial and temporal resolutions and, to this aim, proposes the Rain Class Evaluation from Infrared and Visible observation (RainCEIV) technique. RainCEIV is composed of two modules: a cloud classification algorithm which individuates and characterizes the cloudy pixels, and a supervised classifier that delineates the rainy areas according to the three rainfall intensity classes, the non-rainy (rain rate value < 0.5 mm h-1) class, the light-to-moderate rainy class (0.5 mm h-1 ≤ rain rate value < 4 mm h-1), and the heavy-to-very-heavy-rainy class (rain rate value ≥ 4 mm h-1). The second module considers as input the spectral and textural features of the infrared and visible SEVIRI observations for the cloudy pixels detected by the first module. It also takes the temporal differences of the brightness temperatures linked to the SEVIRI water vapour channels as indicative of the atmospheric instability strongly related to the occurrence of rainfall events. The rainfall rates used in the training phase are obtained through the Precipitation Estimation at Microwave frequencies, PEMW (an algorithm for rain rate retrievals based on Atmospheric Microwave Sounder Unit (AMSU)-B observations). RainCEIV's principal aim is that of supplying preliminary qualitative information on the rainy areas within the Mediterranean Basin where there is no radar network coverage. The results of RainCEIV have been validated against radar-derived rainfall measurements from the Italian Operational Weather Radar Network for some case studies limited to the Mediterranean area. The dichotomous assessment related to daytime (nighttime) validation shows that RainCEIV is able to detect rainy/non-rainy areas with an accuracy of about 97% (96%), and when all the rainy classes are considered, it shows a Heidke skill score of 67% (62%), a bias

  11. Comprehensive detection and identification of bacterial DNA in the blood of patients with sepsis and healthy volunteers using next-generation sequencing method - the observation of DNAemia.

    PubMed

    Gosiewski, T; Ludwig-Galezowska, A H; Huminska, K; Sroka-Oleksiak, A; Radkowski, P; Salamon, D; Wojciechowicz, J; Kus-Slowinska, M; Bulanda, M; Wolkow, P P

    2017-02-01

    Blood is considered to be a sterile microenvironment, in which bacteria appear only periodically. Previously used methods allowed only for the detection of either viable bacteria with low sensitivity or selected species of bacteria. The Next-Generation Sequencing method (NGS) enables the identification of all bacteria in the sample with their taxonomic classification. We used NGS for the analysis of blood samples from healthy volunteers (n = 23) and patients with sepsis (n = 62) to check whether any bacterial DNA exists in the blood of healthy people and to identify bacterial taxonomic profile in the blood of septic patients. The presence of bacterial DNA was found both in septic and healthy subjects; however, bacterial diversity was significantly different (P = 0.002) between the studied groups. Among healthy volunteers, a significant predominance of anaerobic bacteria (76.2 %), of which most were bacteria of the order Bifidobacteriales (73.0 %), was observed. In sepsis, the majority of detected taxa belonged to aerobic or microaerophilic microorganisms (75.1 %). The most striking difference was seen in the case of Actinobacteria phyla, the abundance of which was decreased in sepsis (P < 0.001) and Proteobacteria phyla which was decreased in the healthy volunteers (P < 0.001). Our research shows that bacterial DNA can be detected in the blood of healthy people and that its taxonomic composition is different from the one seen in septic patients. Detection of bacterial DNA in the blood of healthy people may suggest that bacteria continuously translocate into the blood, but not always cause sepsis; this observation can be called DNAemia.

  12. Objective assessment of multimodality optical coherence tomography and second-harmonic generation image quality of ex vivo mouse ovaries using human observers

    NASA Astrophysics Data System (ADS)

    Welge, Weston A.; DeMarco, Andrew T.; Watson, Jennifer M.; Rice, Photini S.; Barton, Jennifer K.; Kupinski, Matthew A.

    2014-03-01

    Ovarian cancer is particularly deadly because it is usually diagnosed after it has begun to spread. Transvaginal sonography (TVS) is the most common imaging screening technique. However, routine use of TVS has not reduced ovarian cancer mortality. The superior resolution of optical imaging techniques may make them attractive alternatives to TVS. We have previously identified features of ovarian cancer using optical coherence tomography (OCT) and secondharmonic generation (SHG) microscopy (with collagen as the targeted fluorophore). OCT provides a gross anatomical image of the ovary while SHG provides a closer look at a particular region. Knowing these anatomical features, we sought to investigate the diagnostic potential of OCT and SHG. We conducted a fully crossed, multi-reader, multi-case study using seven human observers. Each observer classified 44 ex vivo mouse ovaries as normal or abnormal from OCT, SHG, and simultaneous, co-registered OCT and SHG images and provided a confidence rating on a three-point ordinal scale. We determined the average receiver operating characteristic (ROC) curves, area under the ROC curves (AUC), and other quantitative figures of merit. The results show that OCT has diagnostic potential with an average AUC of 0.91 +/- 0.03. The average AUC for SHG was less promising at 0.71 +/- 0.06. Interestingly, the average AUC for simultaneous, co-registered OCT and SHG was not significantly different from OCT alone. This suggests that collagen may not be a useful fluorophore for ovarian cancer screening. The high performance of OCT warrants further investigation.

  13. Successes of a new NSF Research Experience for Teachers (RET): Water-Energy Education for the Next Generation (WE2NG) Empowers K-12 Educators to Train Our Future Scientists to Solve Critical STEM Issues

    NASA Astrophysics Data System (ADS)

    Blaine, A. C.; Martin, A. C.; Hogue, T. S.

    2016-12-01

    Colorado School of Mines (CSM) recently kicked-off a three year K-12 teacher training program with an inaugural six-week summer Research Experience for Teachers (RET). The WE2NG, or Water-Energy Education for the Next Generation program, hosted nine Colorado public school teachers, giving them content and tools to enhance curricula and STEM topics in the classroom. WE2NG is an NSF (National Science Foundation) RET program that seeks to advance public knowledge and dialogue on the water-energy nexus through integration of teachers, and ultimately their students, by infusing standards-based, active-learning lessons with cutting-edge research in the water-energy nexus. The teachers' experience begins with a six week summer program at CSM that consists of different activities collectively integrated to give participants a holistic understanding of STEM research from inception to actualization. Three days a week, the participants focus on integration into a mentor faculty's research projects concerning water and/or energy. During the other two days, participants benefit from research presentations and lab tours from participating faculty, technical workshops on interdisciplinary topics, interaction with industry via field trips and speakers, and professional collaborative STEM curriculum development training. However, the teachers' experience does not end with the summer program; WE2NG also establishes long-term col