Alternative forms of the Spencer-Fano equation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Inokuti, M.; Kowari, K.

We point out a relation between the electron degradation spectra determined by two differing cross-section sets but subject to the same source. The relation takes a form of the Fredholm integral equation of the second kind and may be viewed as an alternative form of the Spencer-Fano equation. The relation leads to a precise definition of the partial degradation spectra of electrons of successive generations. It also provides a basis for the perturbation theory by which one calculates effects of small changes of cross-section data upon the electron degradation spectrum.

20 CFR 200.3 - Obtaining forms from the Railroad Retirement Board.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Obtaining forms from the Railroad Retirement Board. 200.3 Section 200.3 Employees' Benefits RAILROAD RETIREMENT BOARD GENERAL ADMINISTRATION GENERAL ADMINISTRATION § 200.3 Obtaining forms from the Railroad Retirement Board. Forms used by the Board, including...

[Alternate form of the test de aprendizaje verbal España-Complutense (TAVEC)].

PubMed

Nieto, Antonieta; Hernández-Rodríguez, Edith; Hernández-Torres, Atteneri; Velasco Rodríguez-Solís, Pedro; Hess-Medler, Stephany; Machado-Fernández, Alejandra; Molina-Rodríguez, Yaiza; Barroso, José

2014-05-01

Parallel forms of neuropsychological tests are scarce. Practice effects associated to repeated testing with the same test confound the interpretation of observed changes in serial assessments. Practice effects are especially likely with memory testing. To develop an alternate form to the test de aprendizaje verbal España-Complutense (TAVEC), one of the most common memory tests used for Spanish speaking population. Participants in the normative study were 110 undergraduates. Participants in the study of the alternate vs original forms were 70 neurologically normal volunteers ranged in age from 18 to 89 years. Forms were administered in counterbalanced order, with a test-retest interval of 15-20 days. Multivariate analyses showed that none of the effects for form, order of administration or session achieved significance. Interactions also failed to reach significance. Aforementioned results were observed in the total sample and the different age groups: young adults (18-29 years), middle-age (30-59 years) and older (60-89 years). Correlational analyses supported the validity and internal consistence of the alternate form. Results indicate the equivalence between the original TAVEC and the form elaborated in this study. This alternate form may be used in serial assessment of learning and memory deterioration.

Alternative High-Performance Ceramic Waste Forms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sundaram, S. K.

This final report (M5NU-12-NY-AU # 0202-0410) summarizes the results of the project titled “Alternative High-Performance Ceramic Waste Forms,” funded in FY12 by the Nuclear Energy University Program (NEUP Project # 12-3809) being led by Alfred University in collaboration with Savannah River National Laboratory (SRNL). The overall focus of the project is to advance fundamental understanding of crystalline ceramic waste forms and to demonstrate their viability as alternative waste forms to borosilicate glasses. We processed single- and multiphase hollandite waste forms based on simulated waste streams compositions provided by SRNL based on the advanced fuel cycle initiative (AFCI) aqueous separation process developed in the Fuel Cycle Research and Development (FCR&D). For multiphase simulated waste forms, oxide and carbonate precursors were mixed together via ball milling with deionized water using zirconia media in a polyethylene jar for 2 h. The slurry was dried overnight and then separated from the media. The blended powders were then subjected to melting or spark plasma sintering (SPS) processes. Microstructural evolution and phase assemblages of these samples were studied using x-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersion analysis of x-rays (EDAX), wavelength dispersive spectrometry (WDS), transmission electron spectroscopy (TEM), selective area x-ray diffraction (SAXD), and electron backscatter diffraction (EBSD). These results showed that the processing methods have significant effect on the microstructure and thus the performance of these waste forms. The Ce substitution into zirconolite and pyrochlore materials was investigated using a combination of experimental (in situ XRD and x-ray absorption near edge structure (XANES)) and modeling techniques to study these single phases independently. In zirconolite materials, a transition from the 2M to the 4M polymorph was observed with increasing Ce content. The resulting

15 CFR 711.6 - Where to obtain forms.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Where to obtain forms. 711.6 Section 711.6 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU... INFORMATION REGARDING DECLARATION, REPORTING, AND ADVANCE NOTIFICATION REQUIREMENTS, AND THE ELECTRONIC FILING...

15 CFR 782.5 - Where to obtain APR report forms.

Code of Federal Regulations, 2010 CFR

2010-01-01

... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS GENERAL... forms required by the APR may be downloaded from the Internet at http://www.ap.gov. You also may obtain these forms by contacting: Treaty Compliance Division, Bureau of Industry and Security, U.S. Department...

15 CFR 782.5 - Where to obtain APR report forms.

Code of Federal Regulations, 2013 CFR

2013-01-01

... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS GENERAL... forms required by the APR may be downloaded from the Internet at http://www.ap.gov. You also may obtain these forms by contacting: Treaty Compliance Division, Bureau of Industry and Security, U.S. Department...

15 CFR 782.5 - Where to obtain APR report forms.

Code of Federal Regulations, 2011 CFR

2011-01-01

... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS GENERAL... forms required by the APR may be downloaded from the Internet at http://www.ap.gov. You also may obtain these forms by contacting: Treaty Compliance Division, Bureau of Industry and Security, U.S. Department...

15 CFR 782.5 - Where to obtain APR report forms.

Code of Federal Regulations, 2012 CFR

2012-01-01

... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS GENERAL... forms required by the APR may be downloaded from the Internet at http://www.ap.gov. You also may obtain these forms by contacting: Treaty Compliance Division, Bureau of Industry and Security, U.S. Department...

15 CFR 782.5 - Where to obtain APR report forms.

Code of Federal Regulations, 2014 CFR

2014-01-01

... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS GENERAL... forms required by the APR may be downloaded from the Internet at http://www.ap.gov. You also may obtain these forms by contacting: Treaty Compliance Division, Bureau of Industry and Security, U.S. Department...

19 CFR 141.33 - Alternative form for noncommercial shipment.

Code of Federal Regulations, 2010 CFR

2010-04-01

...; DEPARTMENT OF THE TREASURY (CONTINUED) ENTRY OF MERCHANDISE Powers of Attorney § 141.33 Alternative form for... importer may appoint another individual as his unpaid agent for Customs purposes by executing a power of... authorized to execute, as an unpaid agent who has knowledge of the facts, pursuant to the provisions of...

29 CFR 4044.73 - Lump sums and other alternative forms of distribution in lieu of annuities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... distribution is the present value of the normal form of benefit provided by the plan payable at normal... 29 Labor 9 2010-07-01 2010-07-01 false Lump sums and other alternative forms of distribution in... Benefits and Assets Non-Trusteed Plans § 4044.73 Lump sums and other alternative forms of distribution in...

Alternate Forms Reliability of the Behavioral Relaxation Scale: Preliminary Results

ERIC Educational Resources Information Center

Lundervold, Duane A.; Dunlap, Angel L.

2006-01-01

Alternate forms reliability of the Behavioral Relaxation Scale (BRS; Poppen,1998), a direct observation measure of relaxed behavior, was examined. A single BRS score, based on long duration observation (5-minute), has been found to be a valid measure of relaxation and is correlated with self-report and some physiological measures. Recently,…

Administration of Caffeine in Alternate Forms.

PubMed

Wickham, Kate A; Spriet, Lawrence L

2018-03-01

There has been recent interest in the ergogenic effects of caffeine delivered in low doses (~ 200 mg or ~ 3 mg/kg body mass) and administered in forms other than capsules, coffee and sports drinks, including chewing gum, bars, gels, mouth rinses, energy drinks and aerosols. Caffeinated chewing gum is absorbed quicker through the buccal mucosa compared with capsule delivery and absorption in the gut, although total caffeine absorption over time is not different. Rapid absorption may be important in many sporting situations. Caffeinated chewing gum improved endurance cycling performance, and there is limited evidence that repeated sprint cycling and power production may also be improved. Mouth rinsing with caffeine may stimulate nerves with direct links to the brain, in addition to caffeine absorption in the mouth. However, caffeine mouth rinsing has not been shown to have significant effects on cognitive performance. Delivering caffeine with mouth rinsing improved short-duration, high-intensity, repeated sprinting in normal and depleted glycogen states, while the majority of the literature indicates no ergogenic effect on aerobic exercise performance, and resistance exercise has not been adequately studied. Studies with caffeinated energy drinks have generally not examined the individual effects of caffeine on performance, making conclusions about this form of caffeine delivery impossible. Caffeinated aerosol mouth and nasal sprays may stimulate nerves with direct brain connections and enter the blood via mucosal and pulmonary absorption, although little support exists for caffeine delivered in this manner. Overall, more research is needed examining alternate forms of caffeine delivery including direct measures of brain activation and entry of caffeine into the blood, as well as more studies examining trained athletes and female subjects.

Loop-driven conformational transition between the alternative and collapsed form of prethrombin-2: targeted molecular dynamics study.

PubMed

Wu, Sangwook

2017-01-01

Two distinct crystal structures of prethrombin-2, the alternative and collapsed forms, are elucidated by X-ray crystallogrphy. We analyzed the conformational transition from the alternative to the collapsed form employing targeted molecular dynamics (TMD) simulation. Despite small RMSD difference in the two X-ray crystal structures, some hydrophobic residues (W60d, W148, W215, and F227) show a significant difference between the two conformations. TMD simulation shows that the four hydrophobic residues undergo concerted movement from dimer to trimer transition via tetramer state in the conformational change from the alternative to the collapsed form. We reveal that the concerted movement of the four hydrophobic residues is controlled by movement of specific loop regions behind. In this paper, we propose a sequential scenario for the conformational transition from the alternative form to the collapsed form, which is partially supported by the mutant W148A simulation.

Influence of moisture on the crystal forms of niclosamide obtained from acetone and ethyl acetate.

PubMed

Manek, Rahul V; Kolling, William M

2004-03-04

The purpose of this study was to elucidate the formation of crystal hydrates of niclosamide and to delineate the effect of relative humidity on the crystal forms obtained from acetone and ethyl acetate. Recrystallization of niclosamide was performed in the presence and absence of moisture. Two hydrates and their corresponding anhydrates were isolated. The hydrates obtained by the process of recrystallization from acetone (Form I) and that obtained from ethyl acetate (Form II) were classified based on differences in their dehydration profile, crystal structure, shape, and morphology. Crystals obtained in the absence of moisture were unstable, and when exposed to the laboratory atmosphere transformed to their corresponding hydrates. Differential scanning calorimetry thermograms indicate that Form I changes to an anhydrate at temperatures below 100 degrees C, while Form II dehydrates in a stepwise manner above 140 degrees C. This finding was further confirmed by thermogravimetric analysis. Dehydration of Form II was accompanied by a loss of structural integrity, demonstrating that water molecules play an important role in maintaining its crystal structure. Form I, Form II, and the anhydrate of Form II showed no significant moisture sorption over the entire range of relative humidity. Although the anhydrate of Form I did not show any moisture uptake at low humidity, it converted to the monohydrate at elevated relative humidity (>95%). All forms could be interconverted depending on the solvent and humidity conditions.

A Comparison of Alternate-Choice and True-False Item Forms Used in Classroom Examinations.

ERIC Educational Resources Information Center

Maihoff, N. A.; Mehrens, Wm. A.

A comparison is presented of alternate-choice and true-false item forms used in an undergraduate natural science course. The alternate-choice item is a modified two-choice multiple-choice item in which the two responses are included within the question stem. This study (1) compared the difficulty level, discrimination level, reliability, and…

Homeschooling as an Alternative Form of Educational Provision in South Africa and the USA

ERIC Educational Resources Information Center

de Waal, Esther; Theron, Tinie

2003-01-01

This paper studies homeschooling as an alternative form of educational provision in South Africa and USA to determine what knowledge and experiences from research on homeschooling in the USA may be relevant to the South Africa situation. Homeschooling in the USA has a sound legal foundation and has become an acceptable educational alternative.…

Alternative medicine complements standard. Various forms focus on holistic concepts.

PubMed

Seaward, B L

1994-09-01

Western or conventional medical practices are founded on the principle of Newtonian physics; the body is viewed as a large clock whose broken parts are fixed or replaced. The placebo effect, hypnosis, psychoneuroimmunology, and spontaneous remission have recently inspired researchers to look beyond this mechanistic model toward a new paradigm of greater understanding regarding the entity we call "human beings." The premise of alternative medicine, based on the paradigm of whole systems, suggests that human beings are more than physical bodies with fixable and replaceable parts; they are a complicated network of pulsating energy frequencies often described in terms of a human aura. Western researchers now call this "the human energy field." Homeopathy, acupuncture, polarity healing, and the healing power of touch are only a few of the more common branches of holistic medicine that unite body, mind, and spirit for optimal health. The U.S. Congress has appropriated more than $2 million to the National Institutes of Health to research the validity of alternative or complementary medicines. In light of proposed changes in the healthcare system, alternative medicine may eventually be incorporated into the American structure of healthcare delivery. Proponents of holistic medicine agree that various forms of alternative medicine should be used to complement, rather than compete, with, the current accepted standard of healthcare.

Alternative Forms of Mentoring in Changing Organizational Environments: A Conceptual Extension of the Mentoring Literature.

ERIC Educational Resources Information Center

Eby, Lillian T.

1997-01-01

This typology of alternative forms of mentoring has two dimensions: (1) form of relationship (lateral/hierarchical) and (2) type of skill development (job or career related). Mentoring forms discussed include intra- and interteam, coworker, survivor, peer, internal and external collegial, internal and external sponsor, manager-subordinate, and…

Study of the liquid-film-forming apparatus as an alternative aeration system: design criteria and operating condition.

PubMed

Hongprasith, Narapong; Imai, Tsuyoshi; Painmanakul, Pisut

2017-06-01

Aeration is an important factor in aquaculture systems because it is a vital condition for all organisms that live in water and respire aerobically. Generally, mechanical surface aerators are widely used in Thailand due to their advantage for increasing dissolved oxygen (DO) and for their horizontal mixing of aquaculture ponds with large surface areas. However, these systems still have some drawbacks, primarily the low oxygen transfer efficiency (OTE) and energy. Regarding this issue, alternative aeration systems should be studied and applied. Therefore, this research aims to study the aeration mechanism obtained by the diffused-air aeration combined with a liquid-film-forming apparatus (LFFA). The effect of gas flow rates, types, and patterns of aerator installation were investigated in an aquaculture pond of 10 m × 10 m × 1.5 m. The analytical parameters were volumetric mass transfer coefficient (k L a), OTE, and aeration efficiency (AE). From the results, the '4-D' with partitions was proposed as the suitable pattern for the LFFA installation. The advantage could be obtained from high energy performance with 1.2 kg/kW h of AE. Then, the operation conditions can be applied as a design guideline for this alternative aeration system in the aquaculture ponds.

Reliability and equivalence of alternate forms for the Symbol Digit Modalities Test: implications for multiple sclerosis clinical trials.

PubMed

Benedict, Ralph H B; Smerbeck, Audrey; Parikh, Rajavi; Rodgers, Jonathan; Cadavid, Diego; Erlanger, David

2012-09-01

Cognitive impairment is common in multiple sclerosis (MS), but is seldom assessed in clinical trials investigating the effects of disease-modifying therapies. The Symbol Digit Modalities Test (SDMT) is a particularly promising tool due to its sensitivity and robust correlation with brain magnetic resonance imaging (MRI) and vocational disability. Unfortunately, there are no validated alternate SDMT forms, which are needed to mitigate practice effects. The aim of the study was to assess the reliability and equivalence of SDMT alternate forms. Twenty-five healthy participants completed each of five alternate versions of the SDMT - the standard form, two versions from the Rao Brief Repeatable Battery, and two forms specifically designed for this study. Order effects were controlled using a Latin-square research design. All five versions of the SDMT produced mean values within 3 raw score points of one another. Three forms were very consistent, and not different by conservative statistical tests. The SDMT test-retest reliability using these forms was good to excellent, with all r values exceeding 0.80. For the first time, we find good evidence that at least three alternate versions of the SDMT are of equivalent difficulty in healthy adults. The forms are reliable, and can be implemented in clinical trials emphasizing cognitive outcomes.

To Love, Honor, and Obey? Traditional Legal Marriage and Alternative Family Forms

ERIC Educational Resources Information Center

Weitzman, Lenore J.

1975-01-01

Legal obligations of spouses are examined in the first half of this article. The second half of the article examines explicit legal restrictions on alternative family forms--homosexual unions, communes, and egalitarian-partnership marriages. The final section reviews developments in the law which may provide increased legal protection for…

Do Jurors Get What They Expect? Traditional versus Alternative Forms of Children's Testimony

PubMed Central

McAuliff, Bradley D.; Kovera, Margaret Bull

2011-01-01

This study examined prospective jurors' expectancies for the verbal and nonverbal behavior of a child testifying in a sexual abuse case. Community members (N = 261) reporting for jury duty completed a survey in which they described their expectancies for how a child alleging sexual abuse would appear when testifying and their beliefs about discerning children's truthfulness, testimony stress, and fairness to trial parties. Within this survey, we varied the child's age (5, 10, or 15 years old), type of abuse alleged (vaginal fondling or penetration), and whether the abuse actually occurred (yes, no) between participants across five different testimony conditions (traditional live in-court, support person present, closed-circuit television, preparation, and videotape) within each participant. Participants expected a child providing traditional testimony to be more nervous, tearful, and fidgety; less confident, cooperative, and fluent; and to maintain less eye contact and provide shorter responses than when the child provided alternative forms of testimony. Participants believed it was easiest to determine a child's truthfulness and fairest to the defendant when the child testified live in court, but that this form of testimony was the most stressful and unfair to the child. Expectancies and beliefs differed within the alternative forms of testimony as well. Negative evaluations of children's alternative testimony may be the result of expectancy violation; namely, jurors expect differences in children's verbal and nonverbal behavior as a result of accommodation, but those differences actually do not occur. PMID:22523466

Sociocognitive Factors and Perceived Consequences Associated with Alternative Forms of Alcohol Use

ERIC Educational Resources Information Center

Braitman, Abby L.; Linden-Carmichael, Ashley N.; Stamates, Amy L.; Lau-Barraco, Cathy

2017-01-01

Objective: Popular media have highly publicized alternative forms of alcohol use (e.g., eyeballing, inhaling alcohol vapor) among college students as a growing concern, possibly associated with severe health risks. Formative research indicates rarity of use. Participants and Methods: College students (Study 1: n = 411; Study 2: n = 687) completed…

Selfie@ssessment as an Alternative Form of Self-Assessment at Undergraduate Level in Higher Education

ERIC Educational Resources Information Center

Tulgar, Aysegül Takkaç

2017-01-01

This study aimed to get ideas formed by undergraduate foreign language students about the applicability, advantages and disadvantages of "selfie@ssessment", which can be regarded as an alternative form of self-assessment utilizing modern mobile phone technologies and the available Internet facilities. Underpinning this study of…

An Alternative Form of the Defense Mechanisms Inventory: Assessing Chinese University Students

ERIC Educational Resources Information Center

Zhang, Li-Fang

2016-01-01

To overcome the major weakness in the response format of the Defense Mechanisms Inventory and to use the information most relevant to the population concerned in the present study, an alternative form of the Defense Mechanisms Inventory (DMI-AF) was designed. The 80 Likert-scaled items in the inventory were tested among 385 university students in…

Evaluation of final waste forms and recommendations for baseline alternatives to group and glass

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bleier, A.

1997-09-01

An assessment of final waste forms was made as part of the Federal Facilities Compliance Agreement/Development, Demonstration, Testing, and Evaluation (FFCA/DDT&E) Program because supplemental waste-form technologies are needed for the hazardous, radioactive, and mixed wastes of concern to the Department of Energy and the problematic wastes on the Oak Ridge Reservation. The principal objective was to identify a primary waste-form candidate as an alternative to grout (cement) and glass. The effort principally comprised a literature search, the goal of which was to establish a knowledge base regarding four areas: (1) the waste-form technologies based on grout and glass, (2) candidatemore » alternatives, (3) the wastes that need to be immobilized, and (4) the technical and regulatory constraints on the waste-from technologies. This report serves, in part, to meet this goal. Six families of materials emerged as relevant; inorganic, organic, vitrified, devitrified, ceramic, and metallic matrices. Multiple members of each family were assessed, emphasizing the materials-oriented factors and accounting for the fact that the two most prevalent types of wastes for the FFCA/DDT&E Program are aqueous liquids and inorganic sludges and solids. Presently, no individual matrix is sufficiently developed to permit its immediate implementation as a baseline alternative. Three thermoplastic materials, sulfur-polymer cement (inorganic), bitumen (organic), and polyethylene (organic), are the most technologically developed candidates. Each warrants further study, emphasizing the engineering and economic factors, but each also has limitations that regulate it to a status of short-term alternative. The crystallinity and flexible processing of sulfur provide sulfur-polymer cement with the highest potential for short-term success via encapsulation. Long-term immobilization demands chemical stabilization, which the thermoplastic matrices do not offer. Among the properties of the remaining

Alternative antiretroviral therapy formulations for patients unable to swallow solid oral dosage forms.

PubMed

Duggan, Joan M; Akpanudo, Barbara; Shukla, Vipul; Gutterson, Glen; Eitniear, Lindsey; Sahloff, Eric G

2015-09-15

Evidence-based guidance is presented to assist clinicians in selecting alternative formulations of antiretroviral (ARV) agents for patients with human immunodeficiency virus (HIV) infection who are unable to swallow tablets or capsules. The inability to take medications in standard oral dosage forms can be associated with nonadherence or the use of alternative administration strategies such as capsule or tablet breaking, crushing, or chewing. Patients with HIV infection require long-term ARV therapy to maintain viral suppression; ARV agents are predominately available as tablets and capsules that may pose swallowing difficulties for some patients. Using a variety of sources (the primary literature, pharmaceutical package inserts, and requests for unpublished data from drug manufacturers), available evidence on the bioavailability of ARV medications after disruption of the capsule or tablet matrix was reviewed; information on alternative formulations of ARV agents was also assessed. With several ARV agents, disruption of the solid oral dosage form by crushing, chewing, or breaking tablets or opening capsules prior to ingestion has been shown to result in altered bioavailability or pharmacokinetics and thus the potential for incomplete virological suppression, increased adverse effects, and suboptimal health outcomes. Of the 33 single-agent ARV medications and combination ARV products in five classes available at the time of review, approximately half exist as powders, liquids, injectables, or chewable or dissolvable tablets. If alternative ARV formulations or administration methods are used, close monitoring for achievement of virological and immunologic success and potential toxicities is recommended. Copyright © 2015 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

12 CFR 12.5 - Notification by agreement; alternative forms and times of notification.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Notification by agreement; alternative forms and times of notification. 12.5 Section 12.5 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RECORDKEEPING AND CONFIRMATION REQUIREMENTS FOR SECURITIES TRANSACTIONS § 12.5...

41 CFR 102-2.135 - How do agencies obtain forms prescribed by the FMR?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION GENERAL 2-FEDERAL MANAGEMENT REGULATION SYSTEM Forms § 102-2.135 How do agencies obtain forms prescribed by the FMR? For copies..., Fort Worth, TX 76115. (b) Send e-mail messages to: [email protected] (c) Visit our web site at: www.gsa...

Minimally processed beetroot waste as an alternative source to obtain functional ingredients.

PubMed

Costa, Anne Porto Dalla; Hermes, Vanessa Stahl; Rios, Alessandro de Oliveira; Flôres, Simone Hickmann

2017-06-01

Large amounts of waste are generated by the minimally processed vegetables industry, such as those from beetroot processing. The aim of this study was to determine the best method to obtain flour from minimally processed beetroot waste dried at different temperatures, besides producing a colorant from such waste and assessing its stability along 45 days. Beetroot waste dried at 70 °C originates flour with significant antioxidant activity and higher betalain content than flour produced from waste dried at 60 and 80 °C, while chlorination had no impact on the process since microbiological results were consistent for its application. The colorant obtained from beetroot waste showed color stability for 20 days and potential antioxidant activity over the analysis period, thus it can be used as a functional additive to improve nutritional characteristics and appearance of food products. These results are promising since minimally processed beetroot waste can be used as an alternative source of natural and functional ingredients with high antioxidant activity and betalain content.

Searching for an alternative form of life on Earth

NASA Astrophysics Data System (ADS)

Davies, P. C. W.

2007-09-01

Biologists tacitly assume that all life on Earth descended from a common origin. This assumption is based on biochemical similarities and gene sequencing, which enables organisms to be positioned on a common tree of life. However, most terrestrial organisms are microbes, and it is impossible to deduce their biochemical nature from morphology alone. The vast majority of microbes remain unclassified, leaving open the possibility that some of them might be an alternative form of life, arising either from an independent origin, or representing a hitherto overlooked very ancient branch of the known tree. Thus there may exist an extinct, or even extant, shadow biosphere. I discuss various research proposals for locating and identifying "alien" organisms on Earth, both ecologically separate and ecologically integrated.

Cutting blade dentitions in squaliform sharks form by modification of inherited alternate tooth ordering patterns

PubMed Central

Smith, Moya Meredith

2016-01-01

The squaliform sharks represent one of the most speciose shark clades. Many adult squaliforms have blade-like teeth, either on both jaws or restricted to the lower jaw, forming a continuous, serrated blade along the jaw margin. These teeth are replaced as a single unit and successor teeth lack the alternate arrangement present in other elasmobranchs. Micro-CT scans of embryos of squaliforms and a related outgroup (Pristiophoridae) revealed that the squaliform dentition pattern represents a highly modified version of tooth replacement seen in other clades. Teeth of Squalus embryos are arranged in an alternate pattern, with successive tooth rows containing additional teeth added proximally. Asynchronous timing of tooth production along the jaw and tooth loss prior to birth cause teeth to align in oblique sets containing teeth from subsequent rows; these become parallel to the jaw margin during ontogeny, so that adult Squalus has functional tooth rows comprising obliquely stacked teeth of consecutive developmental rows. In more strongly heterodont squaliforms, initial embryonic lower teeth develop into the oblique functional sets seen in adult Squalus, with no requirement to form, and subsequently lose, teeth arranged in an initial alternate pattern. PMID:28018617

Cutting blade dentitions in squaliform sharks form by modification of inherited alternate tooth ordering patterns

NASA Astrophysics Data System (ADS)

Underwood, Charlie; Johanson, Zerina; Smith, Moya Meredith

2016-11-01

The squaliform sharks represent one of the most speciose shark clades. Many adult squaliforms have blade-like teeth, either on both jaws or restricted to the lower jaw, forming a continuous, serrated blade along the jaw margin. These teeth are replaced as a single unit and successor teeth lack the alternate arrangement present in other elasmobranchs. Micro-CT scans of embryos of squaliforms and a related outgroup (Pristiophoridae) revealed that the squaliform dentition pattern represents a highly modified version of tooth replacement seen in other clades. Teeth of Squalus embryos are arranged in an alternate pattern, with successive tooth rows containing additional teeth added proximally. Asynchronous timing of tooth production along the jaw and tooth loss prior to birth cause teeth to align in oblique sets containing teeth from subsequent rows; these become parallel to the jaw margin during ontogeny, so that adult Squalus has functional tooth rows comprising obliquely stacked teeth of consecutive developmental rows. In more strongly heterodont squaliforms, initial embryonic lower teeth develop into the oblique functional sets seen in adult Squalus, with no requirement to form, and subsequently lose, teeth arranged in an initial alternate pattern.

Selection and properties of alternative forming fluids for TRISO fuel kernel production

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baker, M. P.; King, J. C.; Gorman, B. P.

2013-01-01

Current Very High Temperature Reactor (VHTR) designs incorporate TRi-structural ISOtropic (TRISO) fuel, which consists of a spherical fissile fuel kernel surrounded by layers of pyrolytic carbon and silicon carbide. An internal sol-gel process forms the fuel kernel using wet chemistry to produce uranium oxyhydroxide gel spheres by dropping a cold precursor solution into a hot column of trichloroethylene (TCE). Over time, gelation byproducts inhibit complete gelation, and the TCE must be purified or discarded. The resulting TCE waste stream contains both radioactive and hazardous materials and is thus considered a mixed hazardous waste. Changing the forming fluid to a non-hazardousmore » alternative could greatly improve the economics of TRISO fuel kernel production. Selection criteria for a replacement forming fluid narrowed a list of ~10,800 chemicals to yield ten potential replacement forming fluids: 1-bromododecane, 1- bromotetradecane, 1-bromoundecane, 1-chlorooctadecane, 1-chlorotetradecane, 1-iododecane, 1-iodododecane, 1-iodohexadecane, 1-iodooctadecane, and squalane. The density, viscosity, and surface tension for each potential replacement forming fluid were measured as a function of temperature between 25 °C and 80 °C. Calculated settling velocities and heat transfer rates give an overall column height approximation. 1-bromotetradecane, 1-chlorooctadecane, and 1-iodododecane show the greatest promise as replacements, and future tests will verify their ability to form satisfactory fuel kernels.« less

Selection and properties of alternative forming fluids for TRISO fuel kernel production

NASA Astrophysics Data System (ADS)

Baker, M. P.; King, J. C.; Gorman, B. P.; Marshall, D. W.

2013-01-01

Current Very High Temperature Reactor (VHTR) designs incorporate TRi-structural ISOtropic (TRISO) fuel, which consists of a spherical fissile fuel kernel surrounded by layers of pyrolytic carbon and silicon carbide. An internal sol-gel process forms the fuel kernel using wet chemistry to produce uranium oxyhydroxide gel spheres by dropping a cold precursor solution into a hot column of trichloroethylene (TCE). Over time, gelation byproducts inhibit complete gelation, and the TCE must be purified or discarded. The resulting TCE waste stream contains both radioactive and hazardous materials and is thus considered a mixed hazardous waste. Changing the forming fluid to a non-hazardous alternative could greatly improve the economics of TRISO fuel kernel production. Selection criteria for a replacement forming fluid narrowed a list of ˜10,800 chemicals to yield ten potential replacement forming fluids: 1-bromododecane, 1-bromotetradecane, 1-bromoundecane, 1-chlorooctadecane, 1-chlorotetradecane, 1-iododecane, 1-iodododecane, 1-iodohexadecane, 1-iodooctadecane, and squalane. The density, viscosity, and surface tension for each potential replacement forming fluid were measured as a function of temperature between 25 °C and 80 °C. Calculated settling velocities and heat transfer rates give an overall column height approximation. 1-bromotetradecane, 1-chlorooctadecane, and 1-iodododecane show the greatest promise as replacements, and future tests will verify their ability to form satisfactory fuel kernels.

easyCBM Beginning Reading Measures: Grades K-1 Alternate Form Reliability and Criterion Validity with the SAT-10. Technical Report #1403

ERIC Educational Resources Information Center

Wray, Kraig; Lai, Cheng-Fei; Sáez, Leilani; Alonzo, Julie; Tindal, Gerald

2013-01-01

We report the results of an alternate form reliability and criterion validity study of kindergarten and grade 1 (N = 84-199) reading measures from the easyCBM© assessment system and Stanford Early School Achievement Test/Stanford Achievement Test, 10th edition (SESAT/SAT-­10) across 5 time points. The alternate form reliabilities ranged from…

Detecting Answer Copying Using Alternate Test Forms and Seat Locations in Small-Scale Examinations

ERIC Educational Resources Information Center

van der Ark, L. Andries; Emons, Wilco H. M.; Sijtsma, Klaas

2008-01-01

Two types of answer-copying statistics for detecting copiers in small-scale examinations are proposed. One statistic identifies the "copier-source" pair, and the other in addition suggests who is copier and who is source. Both types of statistics can be used when the examination has alternate test forms. A simulation study shows that the…

MinCD cell division proteins form alternating co-polymeric cytomotive filaments

PubMed Central

Ghosal, Debnath; Trambaiolo, Daniel; Amos, Linda A.; Löwe, Jan

2014-01-01

Summary During bacterial cell division, filaments of the tubulin-like protein FtsZ assemble at midcell to form the cytokinetic Z-ring. Its positioning is regulated by the oscillation of MinCDE proteins. MinC is activated by MinD through an unknown mechanism and prevents Z-ring assembly anywhere but midcell. Here, using X-ray crystallography, electron microscopy and in vivo analyses we show that MinD activates MinC by forming a new class of alternating copolymeric filaments that show similarity to eukaryotic septin filaments A non-polymerising mutation in MinD causes aberrant cell division in E. coli. MinCD copolymers bind to membrane, interact with FtsZ, and are disassembled by MinE. Imaging a functional msfGFP-MinC fusion protein in MinE deleted cells reveals filamentous structures. EM imaging of our reconstitution of the MinCD-FtsZ interaction on liposome surfaces reveals a plausible mechanism for regulation of FtsZ ring assembly by MinCD copolymers. PMID:25500731

Estimating Conditional Distributions of Scores on an Alternate Form of a Test. Research Report. ETS RR-15-18

ERIC Educational Resources Information Center

Livingston, Samuel A.; Chen, Haiwen H.

2015-01-01

Quantitative information about test score reliability can be presented in terms of the distribution of equated scores on an alternate form of the test for test takers with a given score on the form taken. In this paper, we describe a procedure for estimating that distribution, for any specified score on the test form taken, by estimating the joint…

College Women's Willingness to Participate in Alternative Marital and Family Forms: 1986 and 2003

ERIC Educational Resources Information Center

Billingham, Robert E., Sr.

2008-01-01

In 1986 (n = 359) and in 2003 (n = 111), single never married women enrolled at a large university in the mid-west completed questionnaires designed to investigate their willingness to participate in 13 different alternative marital and family forms. "Egalitarian" marriage was ranked first by women in both time periods with 93.5 and 95.6 percent…

3D solid supported inter-polyelectrolyte complexes obtained by the alternate deposition of poly(diallyldimethylammonium chloride) and poly(sodium 4-styrenesulfonate)

PubMed Central

Maestro, Armando; Llamas, Sara; Álvarez-Rodríguez, Jesús; Ortega, Francisco; Maroto-Valiente, Ángel

2016-01-01

Summary This work addresses the formation and the internal morphology of polyelectrolyte layers obtained by the layer-by-layer method. A multimodal characterization showed the absence of stratification of the films formed by the alternate deposition of poly(diallyldimethylammonium chloride) and poly(sodium 4-styrenesulfonate). Indeed the final organization might be regarded as three-dimensional solid-supported inter-polyelectrolyte films. The growth mechanism of the multilayers, followed using a quartz crystal microbalance, evidences two different growth trends, which show a dependency on the ionic strength due to its influence onto the polymer conformation. The hydration state does not modify the multilayer growth, but it contributes to the total adsorbed mass of the film. The water associated with the polyelectrolyte films leads to their swelling and plastification. The use of X-ray photoelectron spectroscopy has allowed for deeper insights on the internal structure and composition of the polyelectrolyte multilayers. PMID:26977377

3D solid supported inter-polyelectrolyte complexes obtained by the alternate deposition of poly(diallyldimethylammonium chloride) and poly(sodium 4-styrenesulfonate).

PubMed

Guzmán, Eduardo; Maestro, Armando; Llamas, Sara; Álvarez-Rodríguez, Jesús; Ortega, Francisco; Maroto-Valiente, Ángel; Rubio, Ramón G

2016-01-01

This work addresses the formation and the internal morphology of polyelectrolyte layers obtained by the layer-by-layer method. A multimodal characterization showed the absence of stratification of the films formed by the alternate deposition of poly(diallyldimethylammonium chloride) and poly(sodium 4-styrenesulfonate). Indeed the final organization might be regarded as three-dimensional solid-supported inter-polyelectrolyte films. The growth mechanism of the multilayers, followed using a quartz crystal microbalance, evidences two different growth trends, which show a dependency on the ionic strength due to its influence onto the polymer conformation. The hydration state does not modify the multilayer growth, but it contributes to the total adsorbed mass of the film. The water associated with the polyelectrolyte films leads to their swelling and plastification. The use of X-ray photoelectron spectroscopy has allowed for deeper insights on the internal structure and composition of the polyelectrolyte multilayers.

Impact of alternative energy forms on public utilities

NASA Technical Reports Server (NTRS)

Keith, F. W., Jr.

1977-01-01

The investigation of alternative energy sources by the electric utility industry is discussed. Research projects are reviewed in each of the following areas; solar energy, wind energy conversion, photosynthesis of biomass, ocean thermal energy conversion, geothermal energy, fusion, and the environmental impact of alternative energy sources.

Measurement of impulsive choice in rats: Same and alternate form test-retest reliability and temporal tracking

PubMed Central

Peterson, Jennifer R.; Hill, Catherine C.; Kirkpatrick, Kimberly

2016-01-01

Impulsive choice is typically measured by presenting smaller-sooner (SS) versus larger-later (LL) rewards, with biases towards the SS indicating impulsivity. The current study tested rats on different impulsive choice procedures with LL delay manipulations to assess same-form and alternate-form test-retest reliability. In the systematic-GE procedure (Green & Estle, 2003), the LL delay increased after several sessions of training; in the systematic-ER procedure (Evenden & Ryan, 1996), the delay increased within each session; and in the adjusting-M procedure (Mazur, 1987), the delay changed after each block of trials within a session based on each rat’s choices in the previous block. In addition to measuring choice behavior, we also assessed temporal tracking of the LL delays using the median times of responding during LL trials. The two systematic procedures yielded similar results in both choice and temporal tracking measures following extensive training, whereas the adjusting procedure resulted in relatively more impulsive choices and poorer temporal tracking. Overall, the three procedures produced acceptable same form test-retest reliability over time, but the adjusting procedure did not show significant alternate form test-retest reliability with the other two procedures. The results suggest that systematic procedures may supply better measurements of impulsive choice in rats. PMID:25490901

On the Search for Retrotransposons: Alternative Protocols to Obtain Sequences to Learn Profile Hidden Markov Models.

PubMed

Fischer, Carlos N; Campos, Victor De A; Barella, Victor H

2018-05-01

Profile hidden Markov models (pHMMs) have been used to search for transposable elements (TEs) in genomes. For the learning of pHMMs aimed to search for TEs of the retrotransposon class, the conventional protocol is to use the whole internal nucleotide portions of these elements as representative sequences. To further explore the potential of pHMMs in such a search, we propose five alternative ways to obtain the sets of representative sequences of TEs other than the conventional protocol. In this study, we are interested in Bel-PAO, Copia, Gypsy, and DIRS superfamilies from the retrotransposon class. We compared the pHMMs of all six protocols. The test results show that, for each TE superfamily, the pHMMs of at least two of the proposed protocols performed better than the conventional one and that the number of correct predictions provided by the latter can be improved by considering together the results of one or more of the alternative protocols.

Alternative Electrochemical Salt Waste Forms, Summary of FY11-FY12 Results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Riley, Brian J.; Mccloy, John S.; Crum, Jarrod V.

2014-01-17

The Fuel Cycle Research and Development Program, sponsored by the U.S. Department of Energy Office of Nuclear Energy, is currently investigating alternative waste forms for wastes generated from nuclear fuel processing. One such waste results from an electrochemical separations process, called the “Echem” process. The Echem process utilizes a molten KCl-LiCl salt to dissolve the fuel. This process results in a spent salt containing alkali, alkaline earth, lanthanide halides and small quantities of actinide halides, where the primary halide is chloride with a minor iodide fraction. Pacific Northwest National Laboratory (PNNL) is concurrently investigating two candidate waste forms for themore » Echem spent-salt: high-halide minerals (i.e., sodalite and cancrinite) and tellurite (TeO2)-based glasses. Both of these candidates showed promise in fiscal year (FY) 2009 and FY2010 with a simplified nonradioactive simulant of the Echem waste. Further testing was performed on these waste forms in FY2011 and FY2012 to assess the possibility of their use in a sustainable fuel cycle. This report summarizes the combined results from FY2011 and FY2012 efforts.« less

22 CFR 66.3 - Places at which forms and instructions for use by the public may be obtained.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Places at which forms and instructions for use... which forms and instructions for use by the public may be obtained. (a) All forms and instructions... from the Program Office of NED to the address shown in paragraph (a) of this section. (c) General...

Simulation of fault performance of a diesel engine driven brushless alternator through PSPICE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Narayanan, S.S.Y.; Ananthakrishnan, P.; Hangari, V.U.

1995-12-31

Analysis of the fault performance of a brushless alternator with damper windings in the main alternator has been handled ab initio as a total modeling and simulation problem through proper application of Park`s equivalent circuit approach individually to the main exciter alternator units of the brushless alternator and the same has been implemented through PSPICE. The accuracy of the parameters used in the modeling and results obtained through PSPICE implementation are then evaluated for a specific 125 kVA brushless alternator in two stages as followed: first, by comparison of the predicted fault performance obtained from simulation of the 125 kVAmore » main alternator alone treated as a conventional alternator with the results obtained through the use of closed form analytical expressions available in the literature for fault currents and torques in such conventional alternators. Secondly, by comparison of some of the simulation results with those obtained experimentally on the brushless alternator itself. To enable proper calculation of derating factors to be used in the design of such brushless alternators, simulation results then include harmonic analysis of the steady state fault currents and torques. Throughout these studies, the brushless alternator is treated to be on no load at the instant of occurrence of fault.« less

Assistance with Obtaining a Replacement Card Form

EPA Pesticide Factsheets

Form to be submitted to Section 608 Technician Certification Program Manager if a technician wants to replace a certification card, and the record of the original certification is in the data submitted by companies that have gone out of business.

Evidence for alternative trapping strategies in two forms of the pitcher plant, Nepenthes rafflesiana

PubMed Central

Bauer, Ulrike; Grafe, T. Ulmar; Federle, Walter

2011-01-01

Nepenthes pitchers are specialized leaves that function as insect traps. Several pitcher components may contribute to trapping, including the pitcher fluid, slippery wax crystals and downward-pointing epidermal cells on the inner pitcher wall, and the wetness-dependent pitcher rim (peristome), but the relative importance of these traits is unclear. Mechanisms of prey capture and retention in the field were investigated by quantifying the effect of ‘knock-out’ manipulations of individual pitcher structures, and by testing the ability of pitcher fluids and water to retain insects. Two forms of Nepenthes rafflesiana Jack (‘elongate’ and ‘typical’) with contrasting combinations of pitcher traits were compared. Wax crystals on the inner pitcher wall were found to be the most important trapping structure in the elongate form, whereas the typical form relied primarily on the peristome. The pitcher fluids of both forms, differing markedly in the degree of viscoelasticity, retained significantly more ants than water. The present results show that pitcher plants utilize several mechanisms for prey capture and retention, varying in efficiency and relative importance between forms. It is proposed that these differences represent alternative prey capture strategies that may provide a mechanism to reduce competition and facilitate species co-existence in nutrient-limited habitats. PMID:21459766

Evidence for alternative trapping strategies in two forms of the pitcher plant, Nepenthes rafflesiana.

PubMed

Bauer, Ulrike; Grafe, T Ulmar; Federle, Walter

2011-06-01

Nepenthes pitchers are specialized leaves that function as insect traps. Several pitcher components may contribute to trapping, including the pitcher fluid, slippery wax crystals and downward-pointing epidermal cells on the inner pitcher wall, and the wetness-dependent pitcher rim (peristome), but the relative importance of these traits is unclear. Mechanisms of prey capture and retention in the field were investigated by quantifying the effect of 'knock-out' manipulations of individual pitcher structures, and by testing the ability of pitcher fluids and water to retain insects. Two forms of Nepenthes rafflesiana Jack ('elongate' and 'typical') with contrasting combinations of pitcher traits were compared. Wax crystals on the inner pitcher wall were found to be the most important trapping structure in the elongate form, whereas the typical form relied primarily on the peristome. The pitcher fluids of both forms, differing markedly in the degree of viscoelasticity, retained significantly more ants than water. The present results show that pitcher plants utilize several mechanisms for prey capture and retention, varying in efficiency and relative importance between forms. It is proposed that these differences represent alternative prey capture strategies that may provide a mechanism to reduce competition and facilitate species co-existence in nutrient-limited habitats.

Development, Reliability, and Equivalence of an Alternate Form for the CQ Duty Performance-Based Measure

DTIC Science & Technology

2017-10-01

distinguishes between known- groups of healthy control soldiers and those with traumatic brain injury. As such, the CQDT shows promise in helping to inform...be reliably administered and distinguishes between known- groups of healthy control soldiers and those with traumatic brain injury. As such, the CQDT...healthy controls and SM with mild TBI. If we succeed in developing an equivalent alternate form, the CQD may be used to both identify executive

Form--a matter of generation: the relation of generation, form, and function in the epigenetic theory of Caspar F. Wolff.

PubMed

Witt, Elke

2008-12-01

The question, how organisms obtain their specific complex and functional forms, was widely discussed during the eighteenth century. The theory of preformation, which was the dominant theory of generation, was challenged by different alternative epigenetic theories. By the end of the century it was the vitalist approach most famously advocated by Johann Friedrich Blumenbach that prevailed. Yet the alternative theory of generation brought forward by Caspar Friedrich Wolff was an important contribution to the treatment of this question. He turned his attention from the properties of matter and the forces acting on it towards the level of the processes of generation in order to explain the constitution of organismic forms. By regarding organic structures and forms to be the result of the lawfulness of ongoing processes, he opened up the possibility of a functional but non-teleological explanation of generation, and thereby provided an important complement to materialist and vitalist approaches.

How to Support and Engage Students in Alternative Forms of Education and Training? A Qualitative Study of School Staff Members in Flanders

ERIC Educational Resources Information Center

Van Praag, Lore; Van Caudenberg, Rut; Nouwen, Ward; Clycq, Noel; Timmerman, Christiane

2017-01-01

This study focuses on how students, who for a variety of reasons struggle in mainstream secondary schools, can be supported and engaged by alternative forms of education and training to attain a (formal) qualification. Interviews and focus groups are carried out with school staff members of distinct types of alternative learning arenas in Flanders…

Neural and hybrid modeling: an alternative route to efficiently predict the behavior of biotechnological processes aimed at biofuels obtainment.

PubMed

Curcio, Stefano; Saraceno, Alessandra; Calabrò, Vincenza; Iorio, Gabriele

2014-01-01

The present paper was aimed at showing that advanced modeling techniques, based either on artificial neural networks or on hybrid systems, might efficiently predict the behavior of two biotechnological processes designed for the obtainment of second-generation biofuels from waste biomasses. In particular, the enzymatic transesterification of waste-oil glycerides, the key step for the obtainment of biodiesel, and the anaerobic digestion of agroindustry wastes to produce biogas were modeled. It was proved that the proposed modeling approaches provided very accurate predictions of systems behavior. Both neural network and hybrid modeling definitely represented a valid alternative to traditional theoretical models, especially when comprehensive knowledge of the metabolic pathways, of the true kinetic mechanisms, and of the transport phenomena involved in biotechnological processes was difficult to be achieved.

32 CFR Appendix D to Part 623 - Certificate for Signature by an Alternate (DA Form 4881-1-R)

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 3 2010-07-01 2010-07-01 true Certificate for Signature by an Alternate (DA Form 4881-1-R) D Appendix D to Part 623 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY SUPPLIES AND EQUIPMENT LOAN OF ARMY MATERIEL Pt. 623, App. D Appendix D to Part 623...

Neural and Hybrid Modeling: An Alternative Route to Efficiently Predict the Behavior of Biotechnological Processes Aimed at Biofuels Obtainment

PubMed Central

Saraceno, Alessandra; Calabrò, Vincenza; Iorio, Gabriele

2014-01-01

The present paper was aimed at showing that advanced modeling techniques, based either on artificial neural networks or on hybrid systems, might efficiently predict the behavior of two biotechnological processes designed for the obtainment of second-generation biofuels from waste biomasses. In particular, the enzymatic transesterification of waste-oil glycerides, the key step for the obtainment of biodiesel, and the anaerobic digestion of agroindustry wastes to produce biogas were modeled. It was proved that the proposed modeling approaches provided very accurate predictions of systems behavior. Both neural network and hybrid modeling definitely represented a valid alternative to traditional theoretical models, especially when comprehensive knowledge of the metabolic pathways, of the true kinetic mechanisms, and of the transport phenomena involved in biotechnological processes was difficult to be achieved. PMID:24516363

High Pt utilization PEMFC electrode obtained by alternative ion-exchange/electrodeposition.

PubMed

Chen, Siguo; Wei, Zidong; Li, Hua; Li, Li

2010-12-14

High Pt utilization PEMFC electrodes were prepared by an alternative ion-exchange/electrodeposition (AIEE) technique. The results demonstrated that the MEA employing an AIEE electrode with a Pt loading of 0.014 mg Pt cm(-2) exhibits performance approximately 2.2 times larger than that employing a conventional Nafion-bonded Pt/C electrode with a same Pt loading.

Formed platelet combustor liner construction feasibility, phase A

NASA Technical Reports Server (NTRS)

Hayes, W. A.; Janke, D. E.

1992-01-01

Environments generated in high pressure liquid rocket engines impose severe requirements on regeneratively cooled combustor liners. Liners fabricated for use in high chamber pressures using conventional processes suffer from limitations that can impair operational cycle life and can adversely affect wall compatibility. Chamber liners fabricated using formed platelet technology provide an alternative to conventional regeneratively cooled liners (an alternative that has many attractive benefits). A formed platelet liner is made from a stacked assembly of platelets with channel features. The assembly is diffusion bonded into a flat panel and then three-dimensionally formed into a section of a chamber. Platelet technology permits the liner to have very precisely controlled and thin hot gas walls and therefore increased heat transfer efficiency. Further cooling efficiencies can be obtained through enhanced design flexibility. These advantages translate into increased cycle life and enhanced wall compatibility. The increased heat transfer efficiency can alternately be used to increase engine performance or turbopump life as a result of pressure drop reductions within the regeneratively cooled liner. Other benefits can be obtained by varying the materials of construction within the platelet liner to enhance material compatibility with operating environment or with adjoining components. Manufacturing cost savings are an additional benefit of a formed platelet liner. This is because of reduced touch labor and reduced schedule when compared to conventional methods of manufacture. The formed platelet technology is not only compatible with current state-of-the art combustion chamber structural support and manifolding schemes, it is also an enabling technology that allows the use of other high performance and potentially low cost methods of construction for the entire combustion chamber assembly. The contract under which this report is submitted contains three phases: (1) phase

Alternative medicine - pain relief

MedlinePlus

Acupuncture - pain relief; Hypnosis - pain relief; Guided imagery - pain relief ... forms of alternative medicine. Alternatives to medicines include acupuncture, chiropractic, massage, hypnosis, biofeedback, meditation, yoga, and tai- ...

Readability and Content Assessment of Informed Consent Forms for Medical Procedures in Croatia

PubMed Central

Vučemilo, Luka; Borovečki, Ana

2015-01-01

Background High quality of informed consent form is essential for adequate information transfer between physicians and patients. Current status of medical procedure consent forms in clinical practice in Croatia specifically in terms of the readability and the content is unknown. The aim of this study was to assess the readability and the content of informed consent forms for diagnostic and therapeutic procedures used with patients in Croatia. Methods 52 informed consent forms from six Croatian hospitals on the secondary and tertiary health-care level were tested for reading difficulty using Simple Measure of Gobbledygook (SMOG) formula adjusted for Croatian language and for qualitative analysis of the content. Results The averaged SMOG grade of analyzed informed consent forms was 13.25 (SD 1.59, range 10–19). Content analysis revealed that informed consent forms included description of risks in 96% of the cases, benefits in 81%, description of procedures in 78%, alternatives in 52%, risks and benefits of alternatives in 17% and risks and benefits of not receiving treatment or undergoing procedures in 13%. Conclusions Readability of evaluated informed consent forms is not appropriate for the general population in Croatia. The content of the forms failed to include in high proportion of the cases description of alternatives, risks and benefits of alternatives, as well as risks and benefits of not receiving treatments or undergoing procedures. Data obtained from this research could help in development and improvement of informed consent forms in Croatia especially now when Croatian hospitals are undergoing the process of accreditation. PMID:26376183

Tissue-specific expression and regulation of the alternatively-spliced forms of lysyl hydroxylase 2 (LH2) in human kidney cells and skin fibroblasts.

PubMed

Walker, Linda C; Overstreet, Mayra A; Yeowell, Heather N

2005-01-01

Lysyl hydroxylases 1, 2, and 3 catalyse the hydroxylation of specific lysines in collagen. A small percentage of these hydroxylysine residues are precursors for the cross-link formation essential for the tensile strength of collagen. Lysyl hydroxylase 2 (LH2) exists as two alternatively-spliced forms; the long transcript (the major ubiquitously-expressed form) includes a 63 bp exon (13A) that is spliced out in the short form (expressed, together with the long form, in human kidney, spleen, liver, and placenta). This study shows that this alternative splicing event can be regulated by both cell density and cycloheximide (CHX). Although only the long form of LH2 is detected in untreated confluent human skin fibroblasts, after 24 h treatment with CHX the short LH2 transcript is also expressed. In kidney cells, in which both LH2 transcripts are equally expressed, the long LH2 transcript is significantly decreased after 24 h CHX treatment, whereas expression of the short transcript is slightly increased. This suggests that, in kidney cells, the splicing mechanism for the inclusion of exon 13A in LH2 requires a newly-synthesized protein factor that is suppressed by CHX, whereas, in skin fibroblasts in which levels of LH2 (long) are unaffected, CHX appears to suppress a factor that inhibits exclusion of exon 13A, thereby promoting expression of LH2 (short). As these alternate transcripts of LH2 may have specificity for hydroxylation of lysines in either telopeptide or helical collagen domains, their relative expression determines the type of cross-links formed, thereby affecting collagen strength. Therefore, any perturbation of the regulation of LH2 splicing could influence the stability of the extracellular matrix and contribute to specific connective tissue disorders.

Viscous and thermal modelling of thermoplastic composites forming process

NASA Astrophysics Data System (ADS)

Guzman, Eduardo; Liang, Biao; Hamila, Nahiene; Boisse, Philippe

2016-10-01

Thermoforming thermoplastic prepregs is a fast manufacturing process. It is suitable for automotive composite parts manufacturing. The simulation of thermoplastic prepreg forming is achieved by alternate thermal and mechanical analyses. The thermal properties are obtained from a mesoscopic analysis and a homogenization procedure. The forming simulation is based on a viscous-hyperelastic approach. The thermal simulations define the coefficients of the mechanical model that depend on the temperature. The forming simulations modify the boundary conditions and the internal geometry of the thermal analyses. The comparison of the simulation with an experimental thermoforming of a part representative of automotive applications shows the efficiency of the approach.

Pre-stimulus EEG oscillations correlate with perceptual alternation of speech forms.

PubMed

Barraza, Paulo; Jaume-Guazzini, Francisco; Rodríguez, Eugenio

2016-05-27

Speech perception is often seen as a passive process guided by physical stimulus properties. However, ongoing brain dynamics could influence the subsequent perceptual organization of the speech, to an as yet unknown extent. To elucidate this issue, we analyzed EEG oscillatory activity before and immediately after the repetitive auditory presentation of words inducing the so-called verbal transformation effect (VTE), or spontaneous alternation of meanings due to its rapid repetition. Subjects indicated whether the meaning of the bistable word changed or not. For the Reversal more than for the Stable condition, results show a pre-stimulus local alpha desynchronization (300-50ms), followed by an early post-stimulus increase of local beta synchrony (0-80ms), and then a late increase and decrease of local alpha (200-340ms) and beta (360-440ms) synchrony respectively. Additionally, the ERPs showed that reversal positivity (RP) and reversal negativity components (RN), along with a late positivity complex (LPC) correlate with switching between verbal forms. Our results show how the ongoing dynamics brain is actively involved in the perceptual organization of the speech, destabilizing verbal perceptual states, and facilitating the perceptual regrouping of the elements composing the linguistic auditory stimulus. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Leasing versus Borrowing: Evaluating Alternative Forms of Consumer Credit.

ERIC Educational Resources Information Center

Nunnally, Bennie H., Jr.; Plath, D. Anthony

1989-01-01

Presents a straightforward method for evaluating lease versus borrow (buy) decisions illustrated with actual financing cost data reported to new car purchasers. States that individuals should consider after-tax cash flows associated with alternative arrangements, time in which cash flow occurs, and opportunity cost of capital to identify the least…

The Social Attribution Task-Multiple Choice (SAT-MC): A Psychometric and Equivalence Study of an Alternate Form.

PubMed

Johannesen, Jason K; Lurie, Jessica B; Fiszdon, Joanna M; Bell, Morris D

2013-01-01

The Social Attribution Task-Multiple Choice (SAT-MC) uses a 64-second video of geometric shapes set in motion to portray themes of social relatedness and intentions. Considered a test of "Theory of Mind," the SAT-MC assesses implicit social attribution formation while reducing verbal and basic cognitive demands required of other common measures. We present a comparability analysis of the SAT-MC and the new SAT-MC-II, an alternate form created for repeat testing, in a university sample (n = 92). Score distributions and patterns of association with external validation measures were nearly identical between the two forms, with convergent and discriminant validity supported by association with affect recognition ability and lack of association with basic visual reasoning. Internal consistency of the SAT-MC-II was superior (alpha = .81) to the SAT-MC (alpha = .56). Results support the use of SAT-MC and new SAT-MC-II as equivalent test forms. Demonstrating relatively higher association to social cognitive than basic cognitive abilities, the SAT-MC may provide enhanced sensitivity as an outcome measure of social cognitive intervention trials.

The Social Attribution Task-Multiple Choice (SAT-MC): A Psychometric and Equivalence Study of an Alternate Form

PubMed Central

Johannesen, Jason K.; Lurie, Jessica B.; Fiszdon, Joanna M.; Bell, Morris D.

2013-01-01

The Social Attribution Task-Multiple Choice (SAT-MC) uses a 64-second video of geometric shapes set in motion to portray themes of social relatedness and intentions. Considered a test of “Theory of Mind,” the SAT-MC assesses implicit social attribution formation while reducing verbal and basic cognitive demands required of other common measures. We present a comparability analysis of the SAT-MC and the new SAT-MC-II, an alternate form created for repeat testing, in a university sample (n = 92). Score distributions and patterns of association with external validation measures were nearly identical between the two forms, with convergent and discriminant validity supported by association with affect recognition ability and lack of association with basic visual reasoning. Internal consistency of the SAT-MC-II was superior (alpha = .81) to the SAT-MC (alpha = .56). Results support the use of SAT-MC and new SAT-MC-II as equivalent test forms. Demonstrating relatively higher association to social cognitive than basic cognitive abilities, the SAT-MC may provide enhanced sensitivity as an outcome measure of social cognitive intervention trials. PMID:23864984

Evaluating evaluation forms form.

PubMed

Smith, Roger P

2004-02-01

To provide a tool for evaluating evaluation forms. A new form has been developed and tested on itself and a sample of evaluation forms obtained from the graduate medical education offices of several local universities. Additional forms from hospital administration were also subjected to analysis. The new form performed well when applied to itself. The form performed equally well when applied to the other (subject) forms, although their scores were embarrassingly poor. A new form for evaluating evaluation forms is needed, useful, and now available.

Preformulation considerations for controlled release dosage forms. Part III. Candidate form selection using numerical weighting and scoring.

PubMed

Chrzanowski, Frank

2008-01-01

Two numerical methods, Decision Analysis (DA) and Potential Problem Analysis (PPA) are presented as alternative selection methods to the logical method presented in Part I. In DA properties are weighted and outcomes are scored. The weighted scores for each candidate are totaled and final selection is based on the totals. Higher scores indicate better candidates. In PPA potential problems are assigned a seriousness factor and test outcomes are used to define the probability of occurrence. The seriousness-probability products are totaled and forms with minimal scores are preferred. DA and PPA have never been compared to the logical-elimination method. Additional data were available for two forms of McN-5707 to provide complete preformulation data for five candidate forms. Weight and seriousness factors (independent variables) were obtained from a survey of experienced formulators. Scores and probabilities (dependent variables) were provided independently by Preformulation. The rankings of the five candidate forms, best to worst, were similar for all three methods. These results validate the applicability of DA and PPA for candidate form selection. DA and PPA are particularly applicable in cases where there are many candidate forms and where each form has some degree of unfavorable properties.

Developmentally regulated, alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes

PubMed Central

Kawahara, Hiroyuki; Kasahara, Masanori; Nishiyama, Atsuya; Ohsumi, Keita; Goto, Tetsuya; Kishimoto, Takeo; Saeki, Yasushi; Yokosawa, Hideyoshi; Shimbara, Naoki; Murata, Shigeo; Chiba, Tomoki; Suzuki, Koichi; Tanaka, Keiji

2000-01-01

The 26S proteasome is a multisubunit protein- destroying machinery that degrades ubiquitin-tagged proteins. To date only a single species of Rpn10, which possibly functions as a multiubiquitin chain-binding subunit, has been identified in various organisms. Here we report that mouse Rpn10 mRNAs occur in at least five distinct forms, named Rpn10a to Rpn10e, and that they are generated from a single gene by developmentally regulated, alternative splicing. Rpn10a is ubiquitously expressed, whereas Rpn10e is expressed only in embryos, with the highest levels of expression in the brain. Both forms of Rpn10 are components of the 26S proteasome, with an apparently similar affinity for multiubiquitylated [125I]lysozyme in vitro. However, they exert markedly divergent effects on the destruction of B-type cyclin in Xenopus egg extracts. Thus, the 26S proteasome occurs in at least two functionally distinct forms: one containing a ubiquitously expressed Rpn10a and the other a newly identified, embryo-specific Rpn10e. While the former is thought to perform proteolysis constitutively in a wide variety of cells, the latter may play a specialized role in early embryonic development. PMID:10921894

Use of complementary and alternative medicine by patients with arthritis.

PubMed

Unsal, Ayla; Gözüm, Sebahat

2010-04-01

The aims of this study were to determine the prevalence of complementary and alternative medicine use in patients with arthritis, the types of complementary and alternative medicine used, pertinent socio-demographic factors associated with complementary and alternative medicine use and its perceived efficacy. Arthritis is a major health issue, and the use of complementary and alternative medicine among patients with arthritis is common. This is a descriptive cross-sectional study. Data were obtained from 250 patients with arthritis at the physiotherapy and immunology clinics Atatürk University Hospital in eastern Turkey between May-July 2005 using a questionnaire developed specifically for this study. The instrument included questions on socio-demographic information, disease specifics and complementary and alternative medicine usage. Seventy-six per cent of participants reported use of at least one form of complementary and alternative medicine in the previous year. Complementary and alternative medicine users and non-users were not significantly different in most socio-demographic characteristics including age, gender, marital status and education level with the exception of economic status. We categorised treatment into six complementary and alternative medicine categories: 62.6% of patients used thermal therapies; 41.5% used oral herbal therapies; 40.5% used hot therapies; 32.6% used externally applied (skin) therapies; 28.4% used massage and 12.6% used cold therapies. All forms of complementary and alternative medicine except thermal and oral herbal therapies were perceived as very effective by more than half of study participants. Complementary and alternative medicine therapy is widely used by patients with arthritis and has perceived beneficial effects. It is important for nurses and other health care professionals to be knowledgeable about the use of complementary and alternative medicine therapies when providing care to patients with arthritis because of

Securing recruitment and obtaining informed consent in minority ethnic groups in the UK.

PubMed

Lloyd, Cathy E; Johnson, Mark R D; Mughal, Shanaz; Sturt, Jackie A; Collins, Gary S; Roy, Tapash; Bibi, Rukhsana; Barnett, Anthony H

2008-03-30

Previous health research has often explicitly excluded individuals from minority ethnic backgrounds due to perceived cultural and communication difficulties, including studies where there might be language/literacy problems in obtaining informed consent. This study addressed these difficulties by developing audio-recorded methods of obtaining informed consent and recording data. This report outlines 1) our experiences with securing recruitment to a qualitative study investigating alternative methods of data collection, and 2) the development of a standardised process for obtaining informed consent from individuals from minority ethnic backgrounds whose main language does not have an agreed written form. Two researchers from South Asian backgrounds recruited adults with Type 2 diabetes whose main language was spoken and not written, to attend a series of focus groups. A screening tool was used at recruitment in order to assess literacy skills in potential participants. Informed consent was obtained using audio-recordings of the patient information and recording patients' verbal consent. Participants' perceptions of this method of obtaining consent were recorded. Recruitment rates were improved by using telephone compared to face-to-face methods. The screening tool was found to be acceptable by all potential participants. Audio-recorded methods of obtaining informed consent were easy to implement and accepted by all participants. Attrition rates differed according to ethnic group. Snowballing techniques only partly improved participation rates. Audio-recorded methods of obtaining informed consent are an acceptable alternative to written consent in study populations where literacy skills are variable. Further exploration of issues relating to attrition is required, and a range of methods may be necessary in order to maximise response and participation rates.

25 CFR 162.561 - What is the release process for a performance bond or alternative form of security under a WSR...

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false What is the release process for a performance bond or alternative form of security under a WSR lease? 162.561 Section 162.561 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Bonding...

25 CFR 162.561 - What is the release process for a performance bond or alternative form of security under a WSR...

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false What is the release process for a performance bond or alternative form of security under a WSR lease? 162.561 Section 162.561 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Bonding...

A novel color image encryption scheme using alternate chaotic mapping structure

NASA Astrophysics Data System (ADS)

Wang, Xingyuan; Zhao, Yuanyuan; Zhang, Huili; Guo, Kang

2016-07-01

This paper proposes an color image encryption algorithm using alternate chaotic mapping structure. Initially, we use the R, G and B components to form a matrix. Then one-dimension logistic and two-dimension logistic mapping is used to generate a chaotic matrix, then iterate two chaotic mappings alternately to permute the matrix. For every iteration, XOR operation is adopted to encrypt plain-image matrix, then make further transformation to diffuse the matrix. At last, the encrypted color image is obtained from the confused matrix. Theoretical analysis and experimental results has proved the cryptosystem is secure and practical, and it is suitable for encrypting color images.

IMPROVING WILLINGNESS-TO-ACCEPT RESPONSES USING ALTERNATE FORMS OF COMPENSATION

EPA Science Inventory

The purpose of this project is to design a pilot survey to investigate why surveys that ask willingness-to-accept compensation questions so often yield unreliable data and whether respondents would find alternate modes of compensation (specifically, public goods) more acceptab...

Alternative splicing originates different domain structure organization of Lutzomyia longipalpis chitinases.

PubMed

Ortigão-Farias, João Ramalho; Di-Blasi, Tatiana; Telleria, Erich Loza; Andorinho, Ana Carolina; Lemos-Silva, Thais; Ramalho-Ortigão, Marcelo; Tempone, Antônio Jorge; Traub-Csekö, Yara Maria

2018-02-01

BACKGROUND The insect chitinase gene family is composed by more than 10 paralogs, which can codify proteins with different domain structures. In Lutzomyia longipalpis, the main vector of visceral leishmaniasis in Brazil, a chitinase cDNA from adult female insects was previously characterized. The predicted protein contains one catalytic domain and one chitin-binding domain (CBD). The expression of this gene coincided with the end of blood digestion indicating a putative role in peritrophic matrix degradation. OBJECTIVES To determine the occurrence of alternative splicing in chitinases of L. longipalpis. METHODS We sequenced the LlChit1 gene from a genomic clone and the three spliced forms obtained by reverse transcription polymerase chain reaction (RT-PCR) using larvae cDNA. FINDINGS We showed that LlChit1 from L. longipalpis immature forms undergoes alternative splicing. The spliced form corresponding to the adult cDNA was named LlChit1A and the two larvae specific transcripts were named LlChit1B and LlChit1C. The B and C forms possess stop codons interrupting the translation of the CBD. The A form is present in adult females post blood meal, L4 larvae and pre-pupae, while the other two forms are present only in L4 larvae and disappear just before pupation. Two bands of the expected size were identified by Western blot only in L4 larvae. MAIN CONCLUSIONS We show for the first time alternative splicing generating chitinases with different domain structures increasing our understanding on the finely regulated digestion physiology and shedding light on a potential target for controlling L. longipalpis larval development.

Alternative splicing originates different domain structure organization of Lutzomyia longipalpis chitinases

PubMed Central

Ortigão-Farias, João Ramalho; Di-Blasi, Tatiana; Telleria, Erich Loza; Andorinho, Ana Carolina; Lemos-Silva, Thais; Ramalho-Ortigão, Marcelo; Tempone, Antônio Jorge; Traub-Csekö, Yara Maria

2018-01-01

BACKGROUND The insect chitinase gene family is composed by more than 10 paralogs, which can codify proteins with different domain structures. In Lutzomyia longipalpis, the main vector of visceral leishmaniasis in Brazil, a chitinase cDNA from adult female insects was previously characterized. The predicted protein contains one catalytic domain and one chitin-binding domain (CBD). The expression of this gene coincided with the end of blood digestion indicating a putative role in peritrophic matrix degradation. OBJECTIVES To determine the occurrence of alternative splicing in chitinases of L. longipalpis. METHODS We sequenced the LlChit1 gene from a genomic clone and the three spliced forms obtained by reverse transcription polymerase chain reaction (RT-PCR) using larvae cDNA. FINDINGS We showed that LlChit1 from L. longipalpis immature forms undergoes alternative splicing. The spliced form corresponding to the adult cDNA was named LlChit1A and the two larvae specific transcripts were named LlChit1B and LlChit1C. The B and C forms possess stop codons interrupting the translation of the CBD. The A form is present in adult females post blood meal, L4 larvae and pre-pupae, while the other two forms are present only in L4 larvae and disappear just before pupation. Two bands of the expected size were identified by Western blot only in L4 larvae. MAIN CONCLUSIONS We show for the first time alternative splicing generating chitinases with different domain structures increasing our understanding on the finely regulated digestion physiology and shedding light on a potential target for controlling L. longipalpis larval development. PMID:29236932

[Biotechnological cultivation of edible macrofungi: an alternative for obtaining nutraceutics].

PubMed

Suárez Arango, Carolina; Nieto, Ivonne Jeannette

2013-01-03

Macromycetes have been part of the human culture for thousand years, and have been reported as food in the most important civilizations in history. Many nutraceutical properties of macromycetes have been described, such as anti-cancer, anti-tumour, cholesterol lowering, antiviral, antibacterial, or immunomodulatory, among others. Given that production of mushrooms by traditional cultivation and extraction of bioactive metabolites is very difficult in some cases, biotechnology is essential for the development of profitable and productive techniques for obtaining these metabolites. It is the development of this technology, and the ease in which it enables the use of its variables that has allowed mycelium to be cultivated in liquid medium of macrofungi, with a significant reduction in time and an increased production of metabolites. This increased production has led to the study of compounds that have medicinal, nutriceutical and quasi-farmaceutical potential, in the exhausted media and the mycelium. The aim of this review is to provide an overview of the use of liquid-state fermentation as a technological tool for obtaining edible fungi, and the study of these and their metabolites, by describing the different cultivation conditions used in recent years, as well as the results obtained. The relevance of Agaricus, Flammulina, Grifola, Pleurotus and Lentinula genera, will also be discussed, with emphasis on the last one, since Shiitake has been always considered as the ultimate medicinal mushroom. Copyright © 2011 Revista Iberoamericana de Micología. Published by Elsevier España, S.L. All rights reserved.

Alternative analytical forms to model diatomic systems based on the deformed exponential function.

PubMed

da Fonsêca, José Erinaldo; de Oliveira, Heibbe Cristhian B; da Cunha, Wiliam Ferreira; Gargano, Ricardo

2014-07-01

Using a deformed exponential function and the molecular-orbital theory for the simplest molecular ion, two new analytical functions are proposed to represent the potential energy of ground-state diatomic systems. The quality of these new forms was tested by fitting the ab initio electronic energies of the system LiH, LiNa, NaH, RbH, KH, H2, Li2, K2, H 2 (+) , BeH(+) and Li 2 (+) . From these fits, it was verified that these new proposals are able to adequately describe homonuclear, heteronuclear and cationic diatomic systems with good accuracy. Vibrational spectroscopic constant results obtained from these two proposals are in good agreement with experimental data.

5 CFR 2634.905 - Use of alternative procedures.

Code of Federal Regulations, 2014 CFR

2014-01-01

... may use an alternative procedure in lieu of filing the OGE Form 450 or OGE Optional Form 450-A. The alternative procedure may be an agency-specific form to be filed in place thereof. An agency must submit for... that there is no such relationship, she signs and dates a certification which verifies that she has...

5 CFR 2634.905 - Use of alternative procedures.

Code of Federal Regulations, 2012 CFR

2012-01-01

... may use an alternative procedure in lieu of filing the OGE Form 450 or OGE Optional Form 450-A. The alternative procedure may be an agency-specific form to be filed in place thereof. An agency must submit for... that there is no such relationship, she signs and dates a certification which verifies that she has...

5 CFR 2634.905 - Use of alternative procedures.

Code of Federal Regulations, 2013 CFR

2013-01-01

... may use an alternative procedure in lieu of filing the OGE Form 450 or OGE Optional Form 450-A. The alternative procedure may be an agency-specific form to be filed in place thereof. An agency must submit for... that there is no such relationship, she signs and dates a certification which verifies that she has...

5 CFR 2634.905 - Use of alternative procedures.

Code of Federal Regulations, 2011 CFR

2011-01-01

... may use an alternative procedure in lieu of filing the OGE Form 450 or OGE Optional Form 450-A. The alternative procedure may be an agency-specific form to be filed in place thereof. An agency must submit for... that there is no such relationship, she signs and dates a certification which verifies that she has...

Visual search for motion-form conjunctions: is form discriminated within the motion system?

PubMed

von Mühlenen, A; Müller, H J

2001-06-01

Motion-form conjunction search can be more efficient when the target is moving (a moving 45 degrees tilted line among moving vertical and stationary 45 degrees tilted lines) rather than stationary. This asymmetry may be due to aspects of form being discriminated within a motion system representing only moving items, whereas discrimination of stationary items relies on a static form system (J. Driver & P. McLeod, 1992). Alternatively, it may be due to search exploiting differential motion velocity and direction signals generated by the moving-target and distractor lines. To decide between these alternatives, 4 experiments systematically varied the motion-signal information conveyed by the moving target and distractors while keeping their form difference salient. Moving-target search was found to be facilitated only when differential motion-signal information was available. Thus, there is no need to assume that form is discriminated within the motion system.

Assembling the salon: Learning from alternative forms of body work in dementia care.

PubMed

Ward, Richard; Campbell, Sarah; Keady, John

2016-11-01

This article explores the labour and experiences of a hitherto entirely overlooked section of the dementia care workforce: care-based hairdressers. Reporting on findings from the ESRC-funded 'Hair and Care' project, the analysis and discussion focus upon the 'doing of hair' in the context of dementia care. The authors challenge existing assumptions and approaches to the management of appearance in dementia care, arguing for greater recognition of the subjective and culturally meaningful qualities of a visit to the salon. The article draws upon a wider debate on body work as a framework for the discussion, and considers the employment and working conditions of this largely hidden group of workers in the care system. The article offers an account of the praxis of care-based hairdressing, with particular attention paid to narrative, intercorporeal and place-making practices in the salon, showing how a particular approach to the body shapes the labour, relationships and activities that unfold within it. The authors argue that as an alternative form of body work much can be learned from hairdressing that can inform and enhance the provision of dementia care. © 2016 Foundation for the Sociology of Health & Illness.

Conformational dimorphism in o-nitrobenzoic acid: alternative ways to avoid the O...O clash.

PubMed

Ibragimov, Aziz; Ashurov, Jamshid; Ibragimov, Bakhtiyar; Wang, Ai; Mouhib, Halima; Englert, Ulli

2016-07-01

Polymorphism is a challenging phenomenon and the competitive packing alternatives which are characteristic for polymorphs may be encountered for essentially rigid molecules. A second crystal form of the well known compound o-nitrobenzoic acid, C7H5NO4, an important intermediate in the production of dyes, pharmaceuticals and agrochemicals, is described. Although obtained serendipitously, its intra- and intermolecular features match expectations from database searches and theoretical calculations. O-H...O hydrogen-bonded carboxylic acid dimers represent the building blocks in both polymorphs. For steric reasons and in agreement with a calculated potential energy surface, the carboxylic acid and nitro groups cannot simultaneously be coplanar with the benzene ring but have to tilt. In the well established crystal form, this out-of-plane torsion is more pronounced for the nitro substituent. In contrast, the new polymorph is characterized by a major tilt of the carboxylic acid group. The molecules in both alternative crystal forms achieve a similar compromise with respect to acceptable intramolecular O...O contacts.

Method of thermally processing superplastically formed aluminum-lithium alloys to obtain optimum strengthening

NASA Technical Reports Server (NTRS)

Anton, Claire E. (Inventor)

1993-01-01

Optimum strengthening of a superplastically formed aluminum-lithium alloy structure is achieved via a thermal processing technique which eliminates the conventional step of solution heat-treating immediately following the step of superplastic forming of the structure. The thermal processing technique involves quenching of the superplastically formed structure using static air, forced air or water quenching.

Alternative Fuels Data Center

Science.gov Websites

License Fee Each alternative fuel supplier, refiner, distributor, terminal operator, importer or exporter of alternative fuel used in motor vehicles must obtain an annual license from the Wyoming Department of Transportation to conduct business in the state. The fee for each type of license is $25

Consideration of Alternative Educational Systems.

ERIC Educational Resources Information Center

McFann, Howard H.; And Others

A discussion of factors associated with evaluation of proposed alternative educational systems is presented in brief form. Emphasis is given to enumeration of critical characteristics serving as the basis of comparison, examination of alternative systems in terms of each characteristic, and determination based on the comparison as to whether the…

Nominalization and Alternations in Biomedical Language

PubMed Central

Cohen, K. Bretonnel; Palmer, Martha; Hunter, Lawrence

2008-01-01

Background This paper presents data on alternations in the argument structure of common domain-specific verbs and their associated verbal nominalizations in the PennBioIE corpus. Alternation is the term in theoretical linguistics for variations in the surface syntactic form of verbs, e.g. the different forms of stimulate in FSH stimulates follicular development and follicular development is stimulated by FSH. The data is used to assess the implications of alternations for biomedical text mining systems and to test the fit of the sublanguage model to biomedical texts. Methodology/Principal Findings We examined 1,872 tokens of the ten most common domain-specific verbs or their zero-related nouns in the PennBioIE corpus and labelled them for the presence or absence of three alternations. We then annotated the arguments of 746 tokens of the nominalizations related to these verbs and counted alternations related to the presence or absence of arguments and to the syntactic position of non-absent arguments. We found that alternations are quite common both for verbs and for nominalizations. We also found a previously undescribed alternation involving an adjectival present participle. Conclusions/Significance We found that even in this semantically restricted domain, alternations are quite common, and alternations involving nominalizations are exceptionally diverse. Nonetheless, the sublanguage model applies to biomedical language. We also report on a previously undescribed alternation involving an adjectival present participle. PMID:18779866

[Alternative medicine: really an alternative to academic medicine?].

PubMed

Happle, R

2000-06-01

Numerous courses on alternative medicine are regularly advertised in Deutsches Arzteblatt, the organ of the German Medical Association. The present German legislation likewise supports this form of medicine, and this explains why Iscador, an extract of the mistletoe, is found in the Rote Liste, a directory of commercially available medical drugs, under the heading "cytostatic and antimetastatic drugs" although such beneficial effect is unproven. To give another example, a German health insurance fund was sentenced to pay for acupuncture as a treatment for hepatic failure. This judgement is characteristic of the present German judicial system and represents a victory of "oracling irrationalism" (Popper). The astonishing popularity of alternative medicine can be explained by a revival of romanticism. An intellectually fair opposite position has been delineated by Karl Popper in the form of critical rationalism. It is important to realize, however, that our decision to adhere to rational thinking is made in the innermost depth of our heart but not on the basis of rational arguing. Rather, the decision in favor of reason has a moral dimension.

Alternative Forms of International Cooperation: Comparing Their Efficiency

ERIC Educational Resources Information Center

Tinbergen, Jan

1978-01-01

The author, an economist, discusses nine forms of international cooperation according to their strengths, and invites representatives of other disciplines to comment on international cooperation. Discusses relevant concepts and the estimation of optimal procedures for cooperation. Available from: Unipub, Box 433, Murray Hill Station, New York, New…

Alternative acceptance procedures for asphalt mixes.

DOT National Transportation Integrated Search

1992-01-01

By the year 2005, the use of chlorinated solvents is to be eliminated. Faced with this eventuality, VDOT formed a task force to look at alternatives for the acceptance of asphalt mixes. One alternative is to use biodegradable solvents in the extracti...

Alternative approaches to predicting methane emissions from dairy cows.

PubMed

Mills, J A N; Kebreab, E; Yates, C M; Crompton, L A; Cammell, S B; Dhanoa, M S; Agnew, R E; France, J

2003-12-01

Previous attempts to apply statistical models, which correlate nutrient intake with methane production, have been of limited value where predictions are obtained for nutrient intakes and diet types outside those used in model construction. Dynamic mechanistic models have proved more suitable for extrapolation, but they remain computationally expensive and are not applied easily in practical situations. The first objective of this research focused on employing conventional techniques to generate statistical models of methane production appropriate to United Kingdom dairy systems. The second objective was to evaluate these models and a model published previously using both United Kingdom and North American data sets. Thirdly, nonlinear models were considered as alternatives to the conventional linear regressions. The United Kingdom calorimetry data used to construct the linear models also were used to develop the three nonlinear alternatives that were all of modified Mitscherlich (monomolecular) form. Of the linear models tested, an equation from the literature proved most reliable across the full range of evaluation data (root mean square prediction error = 21.3%). However, the Mitscherlich models demonstrated the greatest degree of adaptability across diet types and intake level. The most successful model for simulating the independent data was a modified Mitscherlich equation with the steepness parameter set to represent dietary starch-to-ADF ratio (root mean square prediction error = 20.6%). However, when such data were unavailable, simpler Mitscherlich forms relating dry matter or metabolizable energy intake to methane production remained better alternatives relative to their linear counterparts.

Semi-solid dosage form of clonazepam for rapid oral mucosal absorption.

PubMed

Sakata, Osamu; Machida, Yoshiharu; Onishi, Hiraku

2011-07-01

In order to obtain an alternative to the intravenous (i.v.) dosage form of clonazepam (CZ), an oral droplet formulation of CZ was developed previously; however, the droplet was physically unstable. Therefore, in the present study, it was attempted to develop an easily-handled dosage form, which was more physically stable and allowed rapid drug absorption from oral mucosa. A semi-solid dosage form, composed of polyethylene glycol 1500 (PEG), CZ, and oleic acid (OA) at 37/1/2 (w/w) and named PEG/CZ/OA, and a semi-solid dosage form containing PEG and CZ at 39/1 (w/w), called PEG/CZ, were prepared. Their physical stability in air at room temperature and oral mucosal absorption in rats were investigated. The semi-solid dosage forms were much more stable physically than the droplet, that is, no recrystallization of CZ was observed for at least 8 days. The effective concentration for humans and rats (20 ng/mL or more) was achieved within 30 min after buccal administration for both PEG/CZ/OA and PEG/CZ. The plasma concentration increased gradually and less varied at each time point for PEG/CZ/OA. PEG/CZ/OA was found to show more rapid and higher absorption of CZ in buccal administration than in sublingual administration. Buccal administration with the semi-solid dosage PEG/CZ with or without OA was suggested to be a possibly useful novel dosage form as an alternative to i.v. injection.

Infrared and Visual Image Fusion through Fuzzy Measure and Alternating Operators

PubMed Central

Bai, Xiangzhi

2015-01-01

The crucial problem of infrared and visual image fusion is how to effectively extract the image features, including the image regions and details and combine these features into the final fusion result to produce a clear fused image. To obtain an effective fusion result with clear image details, an algorithm for infrared and visual image fusion through the fuzzy measure and alternating operators is proposed in this paper. Firstly, the alternating operators constructed using the opening and closing based toggle operator are analyzed. Secondly, two types of the constructed alternating operators are used to extract the multi-scale features of the original infrared and visual images for fusion. Thirdly, the extracted multi-scale features are combined through the fuzzy measure-based weight strategy to form the final fusion features. Finally, the final fusion features are incorporated with the original infrared and visual images using the contrast enlargement strategy. All the experimental results indicate that the proposed algorithm is effective for infrared and visual image fusion. PMID:26184229

Infrared and Visual Image Fusion through Fuzzy Measure and Alternating Operators.

PubMed

Bai, Xiangzhi

2015-07-15

The crucial problem of infrared and visual image fusion is how to effectively extract the image features, including the image regions and details and combine these features into the final fusion result to produce a clear fused image. To obtain an effective fusion result with clear image details, an algorithm for infrared and visual image fusion through the fuzzy measure and alternating operators is proposed in this paper. Firstly, the alternating operators constructed using the opening and closing based toggle operator are analyzed. Secondly, two types of the constructed alternating operators are used to extract the multi-scale features of the original infrared and visual images for fusion. Thirdly, the extracted multi-scale features are combined through the fuzzy measure-based weight strategy to form the final fusion features. Finally, the final fusion features are incorporated with the original infrared and visual images using the contrast enlargement strategy. All the experimental results indicate that the proposed algorithm is effective for infrared and visual image fusion.

An Examination of Test-Retest, Alternate Form Reliability, and Generalizability Theory Study of the easyCBM Reading Assessments: Grade 2. Technical Report #1217

ERIC Educational Resources Information Center

Anderson, Daniel; Lai, Cheg-Fei; Park, Bitnara Jasmine; Alonzo, Julie; Tindal, Gerald

2012-01-01

This technical report is one in a series of five describing the reliability (test/retest an alternate form) and G-Theory/D-Study on the easyCBM reading measures, grades 1-5. Data were gathered in the spring of 2011 from the convenience sample of students nested within classrooms at a medium-sized school district in the Pacific Northwest. Due to…

An Examination of Test-Retest, Alternate Form Reliability, and Generalizability Theory Study of the easyCBM Reading Assessments: Grade 1. Technical Report #1216

ERIC Educational Resources Information Center

Anderson, Daniel; Park, Jasmine, Bitnara; Lai, Cheng-Fei; Alonzo, Julie; Tindal, Gerald

2012-01-01

This technical report is one in a series of five describing the reliability (test/retest/and alternate form) and G-Theory/D-Study research on the easy CBM reading measures, grades 1-5. Data were gathered in the spring 2011 from a convenience sample of students nested within classrooms at a medium-sized school district in the Pacific Northwest. Due…

An Examination of Test-Retest, Alternate Form Reliability, and Generalizability Theory Study of the easyCBM Reading Assessments: Grade 5. Technical Report #1220

ERIC Educational Resources Information Center

Lai, Cheng-Fei; Park, Bitnara Jasmine; Anderson, Daniel; Alonzo, Julie; Tindal, Gerald

2012-01-01

This technical report is one in a series of five describing the reliability (test/retest and alternate form) and G-Theory/D-Study research on the easyCBM reading measures, grades 1-5. Data were gathered in the spring of 2011 from a convenience sample of students nested within classrooms at a medium-sized school district in the Pacific Northwest.…

Lunar-forming impacts: processes and alternatives

PubMed Central

Canup, R. M.

2014-01-01

The formation of a protolunar disc by a giant impact with the early Earth is discussed, focusing on two classes of impacts: (i) canonical impacts, in which a Mars-sized impactor produces a planet–disc system whose angular momentum is comparable to that in the current Earth and Moon, and (ii) high-angular-momentum impacts, which produce a system whose angular momentum is approximately a factor of 2 larger than that in the current Earth and Moon. In (i), the disc originates primarily from impactor-derived material and thus is expected to have an initial composition distinct from that of the Earth's mantle. In (ii), a hotter, more compact initial disc is produced with a silicate composition that can be nearly identical to that of the silicate Earth. Both scenarios require subsequent processes for consistency with the current Earth and Moon: disc–planet compositional equilibration in the case of (i), or large-scale angular momentum loss during capture of the newly formed Moon into the evection resonance with the Sun in the case of (ii). PMID:25114302

The Role of Alternative Programming in College Radio.

ERIC Educational Resources Information Center

Sauls, Samuel J.

College radio is quite often viewed as the true alternative to commercial radio. However, what is alternative radio and how does college radio factor into the ideal? To further understand this concept, this paper focuses on the role of alternative programming in college radio. Areas discussed include alternative radio as a non-mainstream form of…

Tropospheric reactions of the haloalkyl radicals formed from hydroxyl radical reaction with a series of alternative fluorocarbons

NASA Technical Reports Server (NTRS)

Atkinson, Roger

1990-01-01

In the present assessment, the hydrogen containing halocarbons being considered as alternatives to the the presently used chlorofluorocarbons are the hydrochlorofluorocarbons (HCFCs) 123 (CF3CHCl2), 141b (CFCl2CH3), 142b (CF2ClCH3), 22 (CHF2Cl) and 124 (CF3CHFCl) and the hydrofluorocarbons (HFCs) 134a (CF3CH2F), 152a (CHF2CH3) and 125 (CF3CHF2). All of these HCFCs and HFCs will react with the hydroxyl (OH) radical in the troposphere, giving rise to haloalkyl radicals which then undergo a complex series of reactions in the troposphere. These reactions of the haloalkyl radicals formed from the initial OH radical reactions with the HCFCs and HFCs under tropospheric conditions are the focus here.

Atomistic modeling of alternating access of a mitochondrial ADP/ATP membrane transporter with molecular simulations

PubMed Central

Hayashi, Shigehiko

2017-01-01

The mitochondrial ADP/ATP carrier (AAC) is a membrane transporter that exchanges a cytosolic ADP for a matrix ATP. Atomic structures in an outward-facing (OF) form which binds an ADP from the intermembrane space have been solved by X-ray crystallography, and revealed their unique pseudo three-fold symmetry fold which is qualitatively different from pseudo two-fold symmetry of most transporters of which atomic structures have been solved. However, any atomic-level information on an inward-facing (IF) form, which binds an ATP from the matrix side and is fixed by binding of an inhibitor, bongkrekic acid (BA), is not available, and thus its alternating access mechanism for the transport process is unknown. Here, we report an atomic structure of the IF form predicted by atomic-level molecular dynamics (MD) simulations of the alternating access transition with a recently developed accelerating technique. We successfully obtained a significantly stable IF structure characterized by newly formed well-packed and -organized inter-domain interactions through the accelerated simulations of unprecedentedly large conformational changes of the alternating access without a prior knowledge of the target protein structure. The simulation also shed light on an atomistic mechanism of the strict transport selectivity of adenosine nucleotides over guanosine and inosine ones. Furthermore, the IF structure was shown to bind ATP and BA, and thus revealed their binding mechanisms. The present study proposes a qualitatively novel view of the alternating access of transporters having the unique three-fold symmetry in atomic details and opens the way for rational drug design targeting the transporter in the dynamic functional cycle. PMID:28727843

Cloze Listening Test (Form Lisbon and Form Waco).

ERIC Educational Resources Information Center

Bowdidge, John S.

Designed to measure recall of specific information, ability to grasp the thought of a passage as a whole, and ability to apply various contextual clues while listening to a passage of aural communication, each of the alternate forms of the cloze listening test consists of an audio tape recording of approximately twenty minutes duration and a…

22 CFR 5.3 - Rules of procedure, description of forms available or the places at which forms may be obtained...

Code of Federal Regulations, 2010 CFR

2010-04-01

... ORGANIZATION § 5.3 Rules of procedure, description of forms available or the places at which forms may be...., Washington, DC 20520. International educational and cultural exchange program Bureau of Educational and Cultural Affairs Department of State, 2201 C Street NW., Washington, DC 20520. International traffic in...

Color-binding errors during rivalrous suppression of form.

PubMed

Hong, Sang Wook; Shevell, Steven K

2009-09-01

How does a physical stimulus determine a conscious percept? Binocular rivalry provides useful insights into this question because constant physical stimulation during rivalry causes different visual experiences. For example, presentation of vertical stripes to one eye and horizontal stripes to the other eye results in a percept that alternates between horizontal and vertical stripes. Presentation of a different color to each eye (color rivalry) produces alternating percepts of the two colors or, in some cases, a color mixture. The experiments reported here reveal a novel and instructive resolution of rivalry for stimuli that differ in both form and color: perceptual alternation between the rivalrous forms (e.g., horizontal or vertical stripes), with both eyes' colors seen simultaneously in separate parts of the currently perceived form. Thus, the colors presented to the two eyes (a) maintain their distinct neural representations despite resolution of form rivalry and (b) can bind separately to distinct parts of the perceived form.

30 CFR 204.201 - Who may obtain accounting and auditing relief?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Who may obtain accounting and auditing relief... MINERALS REVENUE MANAGEMENT ALTERNATIVES FOR MARGINAL PROPERTIES Accounting and Auditing Relief § 204.201 Who may obtain accounting and auditing relief? (a) You may obtain accounting and auditing relief under...

Evaluating Alternatives to Exclusive "He."

ERIC Educational Resources Information Center

Todd-Mancillas, William R.

A study was conducted to determine the effects on reading comprehension of the use of the exclusive pronoun "he" and more or less contrived alternatives. Subjects, 358 students enrolled in an introduction to human communication at a large northeastern university, read three different forms of the same essay. One essay form exclusively used "he,"…

Prediction of Forming Limit Diagram for Seamed Tube Hydroforming Based on Thickness Gradient Criterion

NASA Astrophysics Data System (ADS)

Chen, Xianfeng; Lin, Zhongqin; Yu, Zhongqi; Chen, Xinping; Li, Shuhui

2011-08-01

This study establishes the forming limit diagram (FLD) for QSTE340 seamed tube hydroforming by finite element method (FEM) simulation. FLD is commonly obtained from experiment, theoretical calculation and FEM simulation. But for tube hydroforming, both of the experimental and theoretical means are restricted in the application due to the equipment costs and the lack of authoritative theoretical knowledge. In this paper, a novel approach of predicting forming limit using thickness gradient criterion (TGC) is presented for seamed tube hydroforming. Firstly, tube bulge tests and uniaxial tensile tests are performed to obtain the stress-strain curve for tube three parts. Then one FE model for a classical tube free hydroforming and another FE model for a novel experimental apparatus by applying the lateral compression force and the internal pressure are constructed. After that, the forming limit strain is calculated based on TGC in the FEM simulation. Good agreement between the simulation and experimental results is indicated. By combining the TGC and FEM, an alternative way of predicting forming limit with enough accuracy and convenience is provided.

Cysteine reacts to form blue-green pigments with thiosulfinates obtained from garlic (Allium sativum L.).

PubMed

Shin, Young Keum; Kyung, Kyu Hang

2014-01-01

Cysteine was found to form pigments with garlic thiosulfinates in this investigation, in contrast to previous reports. Pigments were formed only when the molar concentration ratios of cysteine to total thiosulfinates were smaller than 2:1. Cysteine does not form pigments with thiosulfinates in the same manner as other pigment-forming amino compounds because it has a sulfhydryl (SH) group. A colour reaction of cysteine with thiosulfinates is proposed where colourless disulphide-type S-alk(en)yl mercaptocysteines (SAMCs) are formed first by the SH-involved reaction between cysteine and thiosulfinates, and then SAMCs react with residual thiosulfinates to form pigments. When the cysteine to total thiosulfinate molar concentration ratio was 2:1 or greater, total thiosulfinates were consumed to form SAMCs without leaving any thiosulfinates remaining available for the following colour reactions. Copyright © 2013 Elsevier Ltd. All rights reserved.

40 CFR 372.95 - Alternate threshold certification and instructions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 29 2013-07-01 2013-07-01 false Alternate threshold certification and...: COMMUNITY RIGHT-TO-KNOW Forms and Instructions § 372.95 Alternate threshold certification and instructions. (a) Availability of the alternate threshold certification statement and instructions. Availability of...

Acquisition of Nominal Morphophonological Alternations in Russian

ERIC Educational Resources Information Center

Tomas, Ekaterina; van de Vijver, Ruben; Demuth, Katherine; Petocz, Peter

2017-01-01

Morphophonological alternations can make target-like production of grammatical morphemes challenging due to changes in form depending on the phonological environment. This article explores the acquisition of morphophonological alternations involving the interacting patterns of vowel deletion and stress shift in Russian-speaking children (aged…

Dried blood spot on-card derivatization: an alternative form of sample handling to overcome the instability of thiorphan in biological matrix.

PubMed

Mess, Jean-Nicholas; Taillon, Marie-Pierre; Côté, Cynthia; Garofolo, Fabio

2012-12-01

Thiorphan, the active metabolite of racecadotril, can undergo oxidation in biological matrices such as blood and plasma. In bioanalysis, a general approach for the stabilization of such a molecule is to derivatize the thiol group to a more stable thioether, often requiring complex handling procedures at the clinical site. In this research, the concept of dried blood spot (DBS) on-card derivatization was evaluated to stabilize thiorphan. DBS cards were in-house pre-treated with 2-bromo-3'-methoxyacetophenone and left to dry prior to blood spotting. Thiorphan was shown to be effectively derivatized to thiorphan-methoxyacetophenone once applied on the in-house pre-treated cards. Thiorphan-methoxyacetophenone was extracted by soaking a 6 mm DBS punch in methanol containing the internal standard (thiorphan-methoxyacetophenone-D₅). Chromatographic separation was achieved on a Waters XBridge C₁₈ column with a gradient elution of 5 mM NH₄HCO₃ and methanol in 2.5 min and detection by ESI(+)/MS/MS. A linear (weighted 1/x²) relationship was obtained over a concentration range of 5.00-600.00 ng/mL. The assay met regulatory guidelines acceptance criteria for sensitivity, selectivity, precision and accuracy, matrix effect, recovery, dilution integrity and multiple stability evaluations. The DBS on-card derivatization has shown to be an easy and reliable alternative form of sample collection for the quantification of thiorphan. Copyright © 2012 John Wiley & Sons, Ltd.

A systematic review of the use of dosage form manipulation to obtain required doses to inform use of manipulation in paediatric practice.

PubMed

Richey, Roberta H; Hughes, Clare; Craig, Jean V; Shah, Utpal U; Ford, James L; Barker, Catrin E; Peak, Matthew; Nunn, Anthony J; Turner, Mark A

2017-02-25

This study sought to determine whether there is an evidence base for drug manipulation to obtain the required dose, a common feature of paediatric clinical practice. A systematic review of the data sources, PubMed, EMBASE, CINAHL, IPA and the Cochrane database of systematic reviews, was used. Studies that considered the dose accuracy of manipulated medicines of any dosage form, evidence of safety or harm, bioavailability, patient experience, tolerability, contamination and comparison of methods of manipulation were included. Case studies and letters were excluded. Fifty studies were eligible for inclusion, 49 of which involved tablets being cut, split, crushed or dispersed. The remaining one study involved the manipulation of suppositories of one drug. No eligible studies concerning manipulation of oral capsules or liquids, rectal enemas, nebuliser solutions, injections or transdermal patches were identified. Twenty four of the tablet studies considered dose accuracy using weight and/or drug content. In studies that considered weight using adapted pharmacopoeial specifications, the percentage of halved tablets meeting these specifications ranged from 30% to 100%. Eighteen studies investigated bioavailability, pharmacokinetics or clinical outcomes following manipulations which included nine delayed or modified release formulations. In each of these nine studies the entirety of the dosage form was administered. Only one of the 18 studies was identified where drugs were manipulated to obtain a proportion of the dosage form, and that proportion administered. The five studies that considered patient perception found that having to manipulate the tablets did not have a negative impact on adherence. Of the 49 studies only two studies reported investigating children. This review yielded limited evidence to support manipulation of medicines for children. The results cannot be extrapolated between dosage forms, methods of manipulation or between different brands of the same

Simultaneous quantitative analysis of olmesartan, amlodipine and hydrochlorothiazide in their combined dosage form utilizing classical and alternating least squares based chemometric methods.

PubMed

Darwish, Hany W; Bakheit, Ahmed H; Abdelhameed, Ali S

2016-03-01

Simultaneous spectrophotometric analysis of a multi-component dosage form of olmesartan, amlodipine and hydrochlorothiazide used for the treatment of hypertension has been carried out using various chemometric methods. Multivariate calibration methods include classical least squares (CLS) executed by net analyte processing (NAP-CLS), orthogonal signal correction (OSC-CLS) and direct orthogonal signal correction (DOSC-CLS) in addition to multivariate curve resolution-alternating least squares (MCR-ALS). Results demonstrated the efficiency of the proposed methods as quantitative tools of analysis as well as their qualitative capability. The three analytes were determined precisely using the aforementioned methods in an external data set and in a dosage form after optimization of experimental conditions. Finally, the efficiency of the models was validated via comparison with the partial least squares (PLS) method in terms of accuracy and precision.

Alternative Radioisotopes for Heat and Power Sources

NASA Astrophysics Data System (ADS)

Tinsley, T.; Sarsfield, M.; Rice, T.

Production of 238Pu requires considerable facilities including a nuclear reactor and reprocessing plants that are very expensive to build and operate. Thus, a more economical alternative is very attractive to the industry. There are many alternative radioisotopes that exist but few that satisfy the criteria of performance, availability and cost to produce. Any alternative to 238Pu must exist in a chemical form that is compatible with the materials required to safely encapsulate the heat source at the high temperatures of operation and potential launch failure scenarios. The chemical form must also have suitable thermal properties to ensure maximum energy conversion efficiencies when integrated into radioisotope thermoelectric generators over the required mission durations. In addition, the radiation dose must be low enough for operators during production and not so prohibitive that excessive shielding mass is required on the space craft. This paper will focus on the preferred European alternative of 241Am, and the issues that will need to be addressed.

78 FR 57218 - Proposed Collection; Comment Request for Form 8910

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-17

... 8910, Alternative Motor Vehicle Credit. DATES: Written comments should be received on or before... Motor Vehicle Credit. OMB Number: 1545-1998. Form Number: 8910. Abstract: Taxpayers will file Form 8910 to claim the credit for certain alternative motor vehicles placed in service after 2005. Current...

Parental attitudes toward pediatric use of complementary/alternative medicine in Turkey.

PubMed

Ustuner Top, Fadime; Konuk Sener, Dilek; Cangur, Sengul

2017-07-01

This study was conducted to determine the pediatric usage of complementary/alternative medicine (CAM) by parents in Turkey, the incidence of using these methods, and the factors affecting their use. The sectional and relational design of the study included a sample of 497 parents who took children for treatment at the Maternity and Children's Hospital in Giresun, Turkey. Data for the study were collected via the Personal Information Form and the Evaluation Form for Complementary/Alternative Treatment Use. The data collection tools were filled out by the researchers during the face-to-face interviews. Data obtained from the study were analyzed by Pearson chi-square, Fisher-Freeman-Halton and Fisher's exact (posthoc Bonferroni) tests and Z-test. It was determined that 97.7% of the parents had used at least one CAM method. Moreover, the parents had used CAM methods mostly for respiratory complaints. The CAM methods were most commonly used for the symptoms of fever, diarrhea, and cough. It was observed that the most commonly used alternative methods in the past were vitamin/mineral remedies, cold treatments, and hodja (Islamic teacher) consultations, while the most common alternative methods currently used are massage, music, and cold treatment. In addition, the differences found between CAM users in terms of sociodemographic characteristics were not statistically significant. It is crucial for nurses to learn the characteristics of the health/disease treatments used by those with whom they work in order to increase the efficiency of the service they provide. Thus, it was recommended that nurses should be knowledgeable and aware of the benefits/side effects, treatment methods, and contraindications of CAM. © 2017 Wiley Periodicals, Inc.

46 CFR 177.340 - Alternate design considerations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Alternate design considerations. 177.340 Section 177.340... TONS) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.340 Alternate design considerations. When the structure of vessel is of novel design, unusual form, or special materials, which cannot be reviewed or...

An Examination of Test-Retest, Alternate Form Reliability, and Generalizability Theory Study of the easyCBM Passage Reading Fluency Assessments: Grade 4. Technical Report #1219

ERIC Educational Resources Information Center

Park, Bitnara Jasmine; Anderson, Daniel; Alonzo, Julie; Lai, Cheng-Fei; Tindal, Gerald

2012-01-01

This technical report is one in a series of five describing the reliability (test/retest and alternate form) and G-Theory/D-Study research on the easyCBM reading measures, grades 1-5. Data were gathered in the spring of 2011 from a convenience sample of students nested within classrooms at a medium-sized school district in the Pacific Northwest.…

Identification and characterization of alternatively transcribed form of peroxiredoxin IV gene that is specifically expressed in spermatids of postpubertal mouse testis.

PubMed

Yim, Sun Hee; Kim, Yoo-Jin; Oh, Sue Young; Fujii, Junichi; Zhang, Yan; Gladyshev, Vadim N; Rhee, Sue Goo

2011-11-11

2-Cysteine (Cys) peroxiredoxins (Prxs), which include mammalian Prxs I-IV, possess two conserved Cys residues that are readily oxidized by H(2)O(2) to form a disulfide. In the case of Prx I-III, the disulfide is reduced by thioredoxin, thus enabling these proteins to function as peroxidases. Prx IV was shown previously to be synthesized as a 31-kDa polypeptide with an NH(2)-terminal signal peptide that is subsequently cleaved to generate a 27-kDa form of the protein that is localized to the endoplasmic reticulum. A form of Prx IV, larger than 27 kDa revealed by immunoblot analysis was suggested to represent the unprocessed, 31-kDa form, but this larger form was detected only in spermatids of the postpubertal testis. We now show that the larger form of Prx IV (here designated Prx IV-L) detected in the testis is actually a product of alternative transcription of the Prx IV gene that is encoded by newly identified exon 1A together with exons 2-7 that are shared with the 27-kDa form (designated Prx IV-S). Prx IV-L was detected in spermatids but not in mature sperm, it could form disulfide-linked dimers but not higher order oligomers via oxidation, and it was resistant to hyperoxidation unless additional reductant was added, suggesting that its peroxidase activity is limited in vivo. Phylogenetic analysis showed that the Prx IV-S gene is present in all vertebrates examined, whereas the Prx IV-L gene was detected only in placental mammals. We suggest that Prx IV-L functions as an H(2)O(2) sensor that mediates protein thiol oxidation required for the maturation of spermatozoa in placental mammals.

40 CFR 1502.14 - Alternatives including the proposed action.

Code of Federal Regulations, 2013 CFR

2013-07-01

... impacts of the proposal and the alternatives in comparative form, thus sharply defining the issues and... action so that reviewers may evaluate their comparative merits. (c) Include reasonable alternatives not...

40 CFR 1502.14 - Alternatives including the proposed action.

Code of Federal Regulations, 2011 CFR

2011-07-01

... impacts of the proposal and the alternatives in comparative form, thus sharply defining the issues and... action so that reviewers may evaluate their comparative merits. (c) Include reasonable alternatives not...

40 CFR 1502.14 - Alternatives including the proposed action.

Code of Federal Regulations, 2014 CFR

2014-07-01

... impacts of the proposal and the alternatives in comparative form, thus sharply defining the issues and... action so that reviewers may evaluate their comparative merits. (c) Include reasonable alternatives not...

40 CFR 1502.14 - Alternatives including the proposed action.

Code of Federal Regulations, 2010 CFR

2010-07-01

... impacts of the proposal and the alternatives in comparative form, thus sharply defining the issues and... action so that reviewers may evaluate their comparative merits. (c) Include reasonable alternatives not...

40 CFR 1502.14 - Alternatives including the proposed action.

Code of Federal Regulations, 2012 CFR

2012-07-01

... impacts of the proposal and the alternatives in comparative form, thus sharply defining the issues and... action so that reviewers may evaluate their comparative merits. (c) Include reasonable alternatives not...

Numerical indicators of absorption spectra of green leaf extract obtained from plants of different life forms.

PubMed

Koldaev, Vladimir M; Manyakhin, Artem Yu

2018-06-05

The study was carried out using 58 species of terrestrial plants of different life forms at the start of their fruiting stage. Photoreceptive systems of the leaves were assessed by means of unconventional numerical indicators of absorption spectra, relative photoabsorption coefficient, photosynthetic pigments' integral absorption intensity and relative absorption intensity coefficient. As the study showed, the leaves of all trees and light-demanding grasses favoring open spaces, which were subjected to the study were featured by the lowest values of numerical indicators of absorption spectra (NIAS). Shade-demanding grasses, which grow beneath the canopy, by contrast, were featured by the highest NIAS values. These values of the shrub leaves were in between those of light-demanding plants and shade-demanding ones. The results obtained are consistent with modern visions concerning the biochemistry and the physiology of plants' photoreceptive system. It is appropriate to apply the NIAS, which were used in this study and reflect a leaf's photoreceptive properties, as spectrophotometric criteria for monitoring and environmental management of natural plant resources and agricultural plants. Copyright © 2018 Elsevier B.V. All rights reserved.

10 CFR 435.305 - Alternative compliance procedure.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 3 2012-01-01 2012-01-01 false Alternative compliance procedure. 435.305 Section 435.305... Alternative compliance procedure. (a) If a proposed building design includes unusual or innovative energy... estimated unit energy cost on the compliance forms, on the basis of selecting the optimum levels on the...

10 CFR 435.305 - Alternative compliance procedure.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 3 2013-01-01 2013-01-01 false Alternative compliance procedure. 435.305 Section 435.305... Alternative compliance procedure. (a) If a proposed building design includes unusual or innovative energy... estimated unit energy cost on the compliance forms, on the basis of selecting the optimum levels on the...

10 CFR 435.305 - Alternative compliance procedure.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 3 2014-01-01 2014-01-01 false Alternative compliance procedure. 435.305 Section 435.305... Alternative compliance procedure. (a) If a proposed building design includes unusual or innovative energy... estimated unit energy cost on the compliance forms, on the basis of selecting the optimum levels on the...

Alarin but not its alternative-splicing form, GALP (Galanin-like peptide) has antimicrobial activity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wada, Akihiro, E-mail: a-wada@nagasaki-u.ac.jp; Wong, Pooi-Fong; Hojo, Hironobu

Highlights: • Alarin inhibits the growth of E. coli but not S. aureus. • Alarin’s potency is comparable to LL-37 in inhibiting the growth of E. coli. • Alarin can cause bacterial membrane blebbing. • Alalin does not induce hemolysis on erythrocytes. -- Abstract: Alarin is an alternative-splicing form of GALP (galanin-like peptide). It shares only 5 conserved amino acids at the N-terminal region with GALP which is involved in a diverse range of normal brain functions. This study seeks to investigate whether alarin has additional functions due to its differences from GALP. Here, we have shown using a radialmore » diffusion assay that alarin but not GALP inhibited the growth of Escherichia coli (strain ML-35). The conserved N-terminal region, however, remained essential for the antimicrobial activity of alarin as truncated peptides showed reduced killing effect. Moreover, alarin inhibited the growth of E. coli in a similar potency as human cathelicidin LL-37, a well-studied antimicrobial peptide. Electron microscopy further showed that alarin induced bacterial membrane blebbing but unlike LL-37, it did not cause hemolysis of erythrocytes. In addition, alarin is only active against the gram-negative bacteria, E. coli but not the gram-positive bacteria, Staphylococcus aureus. Thus, these data suggest that alarin has potentials as an antimicrobial and should be considered for the development in human therapeutics.« less

7 CFR 3565.455 - Alternative disposition methods.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 15 2011-01-01 2011-01-01 false Alternative disposition methods. 3565.455 Section 3565.455 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE....455 Alternative disposition methods. The Agency, in its sole discretion, may choose to obtain an...

Alternating hemiplegia: complicated migraine of infancy.

PubMed Central

Hosking, G P; Cavanagh, N P; Wilson, J

1978-01-01

Alternating hemiplegia in children is a rare form of "complicated" migraine. There are a number of similarities to seizure disorders and correct diagnosis may prove difficult. The clinical features of 6 patients with alternating hemiplegia are presented together with the results of electrophysiological, radiological, and biochemical studies. While there were a number of clinical similarities between the patients, extensive investigations failed to demonstrate significant abnormalities. Although a diagnosis of a seizure disorder was suggested at some time in all of the patients, in only 2 was it certain there was a fit. Headaches occurred in the eldest patient (although not always with a hemiplegic attach) while in the younger patients misery often accompanied their attacks. Intellectual status was impaired in 5 patients, although in 2 of these the cause was most likely to be perinatal difficulties. Response to various forms of treatment was generally not encouraging and concern is expressed that this alternating hemiplegia of childhood may carry an unfavourable prognosis. PMID:708103

Alternating hemiplegia: complicated migraine of infancy.

PubMed

Hosking, G P; Cavanagh, N P; Wilson, J

1978-08-01

Alternating hemiplegia in children is a rare form of "complicated" migraine. There are a number of similarities to seizure disorders and correct diagnosis may prove difficult. The clinical features of 6 patients with alternating hemiplegia are presented together with the results of electrophysiological, radiological, and biochemical studies. While there were a number of clinical similarities between the patients, extensive investigations failed to demonstrate significant abnormalities. Although a diagnosis of a seizure disorder was suggested at some time in all of the patients, in only 2 was it certain there was a fit. Headaches occurred in the eldest patient (although not always with a hemiplegic attach) while in the younger patients misery often accompanied their attacks. Intellectual status was impaired in 5 patients, although in 2 of these the cause was most likely to be perinatal difficulties. Response to various forms of treatment was generally not encouraging and concern is expressed that this alternating hemiplegia of childhood may carry an unfavourable prognosis.

75 FR 58417 - Agency Information Collection Activities: Application-Alternative Inspection Services (SENTRI...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-24

... Activities: Application-- Alternative Inspection Services (SENTRI Application and FAST Commercial Driver... including the SENTRI Application (CBP Form 823S) and the FAST Commercial Driver Application (CBP Form 823F.... Title: Application--Alternative Inspection Services including the SENTRI application and the FAST...

Estimating the similarity of alternative Affymetrix probe sets using transcriptional networks

PubMed Central

2013-01-01

Background The usefulness of the data from Affymetrix microarray analysis depends largely on the reliability of the files describing the correspondence between probe sets, genes and transcripts. Particularly, when a gene is targeted by several probe sets, these files should give information about the similarity of each alternative probe set pair. Transcriptional networks integrate the multiple correlations that exist between all probe sets and supply much more information than a simple correlation coefficient calculated for two series of signals. In this study, we used the PSAWN (Probe Set Assignment With Networks) programme we developed to investigate whether similarity of alternative probe sets resulted in some specific properties. Findings PSAWNpy delivered a full textual description of each probe set and information on the number and properties of secondary targets. PSAWNml calculated the similarity of each alternative probe set pair and allowed finding relationships between similarity and localisation of probes in common transcripts or exons. Similar alternative probe sets had very low negative correlation, high positive correlation and similar neighbourhood overlap. Using these properties, we devised a test that allowed grouping similar probe sets in a given network. By considering several networks, additional information concerning the similarity reproducibility was obtained, which allowed defining the actual similarity of alternative probe set pairs. In particular, we calculated the common localisation of probes in exons and in known transcripts and we showed that similarity was correctly correlated with them. The information collected on all pairs of alternative probe sets in the most popular 3’ IVT Affymetrix chips is available in tabular form at http://bns.crbm.cnrs.fr/download.html. Conclusions These processed data can be used to obtain a finer interpretation when comparing microarray data between biological conditions. They are particularly well

Alternative Work Schedules: The State of the Art.

ERIC Educational Resources Information Center

Newstrom, John W.; Pierce, Jon L.

1979-01-01

Presents a typology of modifications to the standard work week, reviews the current state of research-based knowledge regarding the effectiveness of each major type of alternative, and presents implementation suggestions for personnel interested in adopting one or more of the alternative forms. (Author/IRT)

An Alternate Method to Springback Compensation for Sheet Metal Forming

PubMed Central

Omar, Badrul; Jusoff, Kamaruzaman

2014-01-01

The aim of this work is to improve the accuracy of cold stamping product by accommodating springback. This is a numerical approach to improve the accuracy of springback analysis and die compensation process combining the displacement adjustment (DA) method and the spring forward (SF) algorithm. This alternate hybrid method (HM) is conducted by firstly employing DA method followed by the SF method instead of either DA or SF method individually. The springback shape and the target part are used to optimize the die surfaces compensating springback. The hybrid method (HM) algorithm has been coded in Fortran and tested in two- and three-dimensional models. By implementing the HM, the springback error can be decreased and the dimensional deviation falls in the predefined tolerance range. PMID:25165738

75 FR 38821 - Agency Information Collection Activities: Application-Alternative Inspection Services (SENTRI...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-06

... Activities: Application-- Alternative Inspection Services (SENTRI Application and FAST Commercial Driver... Form 823S) and the FAST Commercial Driver Application (CBP Form 823F). This request for comment is...: Application--Alternative Inspection Services including the SENTRI Application and the FAST Commercial Driver...

Various Forms of BRST Symmetry in Abelian 2-FORM Gauge Theory

NASA Astrophysics Data System (ADS)

Rai, Sumit Kumar; Mandal, Bhabani Prasad

We derive the various forms of BRST symmetry using Batalin-Fradkin-Vilkovisky approach in the case of Abelian 2-form gauge theory. We show that the so-called dual BRST symmetry is not an independent symmetry but the generalization of BRST symmetry obtained from the canonical transformation in the bosonic and ghost sector. We further obtain the new forms of both BRST and dual-BRST symmetry by making a general transformation in the Lagrange multipliers of the bosonic and ghost sector of the theory.

Optical apparatus for forming correlation spectrometers and optical processors

DOEpatents

Butler, Michael A.; Ricco, Antonio J.; Sinclair, Michael B.; Senturia, Stephen D.

1999-01-01

Optical apparatus for forming correlation spectrometers and optical processors. The optical apparatus comprises one or more diffractive optical elements formed on a substrate for receiving light from a source and processing the incident light. The optical apparatus includes an addressing element for alternately addressing each diffractive optical element thereof to produce for one unit of time a first correlation with the incident light, and to produce for a different unit of time a second correlation with the incident light that is different from the first correlation. In preferred embodiments of the invention, the optical apparatus is in the form of a correlation spectrometer; and in other embodiments, the apparatus is in the form of an optical processor. In some embodiments, the optical apparatus comprises a plurality of diffractive optical elements on a common substrate for forming first and second gratings that alternately intercept the incident light for different units of time. In other embodiments, the optical apparatus includes an electrically-programmable diffraction grating that may be alternately switched between a plurality of grating states thereof for processing the incident light. The optical apparatus may be formed, at least in part, by a micromachining process.

Optical apparatus for forming correlation spectrometers and optical processors

DOEpatents

Butler, M.A.; Ricco, A.J.; Sinclair, M.B.; Senturia, S.D.

1999-05-18

Optical apparatus is disclosed for forming correlation spectrometers and optical processors. The optical apparatus comprises one or more diffractive optical elements formed on a substrate for receiving light from a source and processing the incident light. The optical apparatus includes an addressing element for alternately addressing each diffractive optical element thereof to produce for one unit of time a first correlation with the incident light, and to produce for a different unit of time a second correlation with the incident light that is different from the first correlation. In preferred embodiments of the invention, the optical apparatus is in the form of a correlation spectrometer; and in other embodiments, the apparatus is in the form of an optical processor. In some embodiments, the optical apparatus comprises a plurality of diffractive optical elements on a common substrate for forming first and second gratings that alternately intercept the incident light for different units of time. In other embodiments, the optical apparatus includes an electrically-programmable diffraction grating that may be alternately switched between a plurality of grating states thereof for processing the incident light. The optical apparatus may be formed, at least in part, by a micromachining process. 24 figs.

77 FR 71481 - Proposed Collection; Comment Request for Form 8911

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-30

... 8911, Alternative Fuel Vehicle Refueling Property Credit. DATES: Written comments should be received [email protected] . SUPPLEMENTARY INFORMATION: Title: Alternative Fuel Vehicle Refueling Property Credit. OMB... vehicle refueling property. Form 8911, Alternative Fuel Vehicle Refueling Property Credit, will be used by...

Forming Refractory Insulation On Copper Wire

NASA Technical Reports Server (NTRS)

Setlock, J.; Roberts, G.

1995-01-01

Alternative insulating process forms flexible coat of uncured refractory insulating material on copper wire. Coated wire formed into coil or other complex shape. Wire-coating apparatus forms "green" coat on copper wire. After wire coiled, heating converts "green" coat to refractory electrical insulator. When cured to final brittle form, insulating material withstands temperatures above melting temperature of wire. Process used to make coils for motors, solenoids, and other electrical devices to be operated at high temperatures.

Alternative Strategies for Pricing Home Work Time.

ERIC Educational Resources Information Center

Zick, Cathleen D.; Bryant, W. Keith

1983-01-01

Discusses techniques for measuring the value of home work time. Estimates obtained using the reservation wage technique are contrasted with market alternative estimates derived with the same data set. Findings suggest that the market alternative cost method understates the true value of a woman's home time to the household. (JOW)

26 CFR 1.41-8T - Alternative incremental credit (temporary).

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Alternative incremental credit (temporary). 1.41... INCOME TAXES Credits Against Tax § 1.41-8T Alternative incremental credit (temporary). (a) [Reserved] For... alternative simplified credit (ASC) and attaches the completed form to the taxpayer's timely filed (including...

Generator for gallium-68 and compositions obtained therefrom

DOEpatents

Neirinckx, Rudi D.; Davis, Michael A.

1981-01-01

A generator for obtaining radioactive gallium-68 from germanium-68 bound in a resin containing unsubstituted phenolic hydroxyl groups. The germanium-68 is loaded into the resin from an aqueous solution of the germanium-68. A physiologically acceptable solution of gallium-68 having an activity of 0.1 to 50 millicuries per milliliter of gallium-68 solution is obtained. The solution is obtained from the bound germanium-68 which forms gallium-68 in situ by eluting the column with a hydrochloric acid solution to form an acidic solution of gallium-68. The acidic solution of gallium-68 can be neutralized.

Complementary and Alternative Medicine Use in Modern Obstetrics: A Survey of the Central Association of Obstetricians & Gynecologists Members.

PubMed

Babbar, Shilpa; Williams, Karen B; Maulik, Dev

2016-10-05

The use of complementary and alternative medicine during pregnancy is currently on the rise. A validated survey was conducted at the Central Association of Obstetrician and Gynecologists annual meeting to evaluate the knowledge, attitude, and practice of general obstetricians and gynecologists and maternal-fetal medicine specialists in America. We obtained 128 responses: 73 electronically (57%) and 55 via the paper survey (43%). Forty-five percent reported personally using complementary and alternative medicine and 9% of women respondents used complementary and alternative medicine during pregnancy. Overall, 62% had advised their patients to utilize some form of complementary and alternative medicine in pregnancy. Biofeedback, massage therapy, meditation, and yoga were considered the most effective modalities in pregnancy (median [semi-interquartile range] = 2 [0.5]). Maternal-fetal medicine specialists were significantly more likely to disagree on the use of complementary and alternative medicine for risk reduction of preterm birth compared to obstetricians and gynecologists (P = .03). As the use of complementary and alternative medicine continues to rise in reproductive-age women, obstetricians will play an integral role in incorporating complementary and alternative medicine use with conventional medicine. © The Author(s) 2016.

Complementary and Alternative Medicine Use in Modern Obstetrics: A Survey of the Central Association of Obstetricians & Gynecologists Members

PubMed Central

Babbar, Shilpa; Williams, Karen B.; Maulik, Dev

2016-01-01

The use of complementary and alternative medicine during pregnancy is currently on the rise. A validated survey was conducted at the Central Association of Obstetrician and Gynecologists annual meeting to evaluate the knowledge, attitude, and practice of general obstetricians and gynecologists and maternal-fetal medicine specialists in America. We obtained 128 responses: 73 electronically (57%) and 55 via the paper survey (43%). Forty-five percent reported personally using complementary and alternative medicine and 9% of women respondents used complementary and alternative medicine during pregnancy. Overall, 62% had advised their patients to utilize some form of complementary and alternative medicine in pregnancy. Biofeedback, massage therapy, meditation, and yoga were considered the most effective modalities in pregnancy (median [semi-interquartile range] = 2 [0.5]). Maternal-fetal medicine specialists were significantly more likely to disagree on the use of complementary and alternative medicine for risk reduction of preterm birth compared to obstetricians and gynecologists (P = .03). As the use of complementary and alternative medicine continues to rise in reproductive-age women, obstetricians will play an integral role in incorporating complementary and alternative medicine use with conventional medicine. PMID:27707901

Alcoholism and alternative splicing of candidate genes.

PubMed

Sasabe, Toshikazu; Ishiura, Shoichi

2010-04-01

Gene expression studies have shown that expression patterns of several genes have changed during the development of alcoholism. Gene expression is regulated not only at the level of transcription but also through alternative splicing of pre-mRNA. In this review, we discuss some of the evidence suggesting that alternative splicing of candidate genes such as DRD2 (encoding dopamine D2 receptor) may form the basis of the mechanisms underlying the pathophysiology of alcoholism. These reports suggest that aberrant expression of splice variants affects alcohol sensitivities, and alcohol consumption also regulates alternative splicing. Thus, investigations of alternative splicing are essential for understanding the molecular events underlying the development of alcoholism.

Alternatives to Piloting Textbooks.

ERIC Educational Resources Information Center

Muther, Connie

1985-01-01

Using short-term pilot programs to evaluate textbooks can lead to unreliable results and interfere with effective education. Alternative methods for evaluating textbook-based programs include obtaining documented analyses of competitors' products from sales agents, visiting districts using programs being considered, and examining publishers' own…

Two drimane lactones, valdiviolide and 11-epivaldiviolide, in the form of a 1:1 cocrystal obtained from Drimys winteri extracts.

PubMed

Paz Robles, Cristian; Mercado, Darío; Suarez, Sebastián; Baggio, Ricardo

2014-12-01

A cocrystal, C15H22O3·C15H22O3, (I), obtained from Drimys winteri, is composed of two isomeric drimane sesquiterpene lactones, namely valdiviolide, (Ia), and 11-epivaldiviolide, (Ib), neither of which has been reported in the crystal form. Both diastereoisomers present three chiral centres at sites 5, 10 and 11, with an SSR sequence in (Ia) and an SSS sequence in (Ib). O-H···O hydrogen bonds bind molecules into chains running along [120] and the chains are in turn linked by π-π stacking interactions to define planar weakly interacting arrays parallel to (001).

Testing an alternate informed consent process.

PubMed

Yates, Bernice C; Dodendorf, Diane; Lane, Judy; LaFramboise, Louise; Pozehl, Bunny; Duncan, Kathleen; Knodel, Kendra

2009-01-01

One of the main problems in conducting clinical trials is low participation rate due to potential participants' misunderstanding of the rationale for the clinical trial or perceptions of loss of control over treatment decisions. The objective of this study was to test an alternate informed consent process in cardiac rehabilitation participants that involved the use of a multimedia flip chart to describe a future randomized clinical trial and then asked, hypothetically, if they would participate in the future trial. An attractive and inviting visual presentation of the study was created in the form of a 23-page flip chart that included 24 color photographs displaying information about the purpose of the study, similarities and differences between the two treatment groups, and the data collection process. We tested the flip chart in 35 cardiac rehabilitation participants. Participants were asked if they would participate in this future study on two occasions: immediately after the description of the flip chart and 24 hours later, after reading through the informed consent document. Participants were also asked their perceptions of the flip chart and consent process. Of the 35 participants surveyed, 19 (54%) indicated that they would participate in the future study. No participant changed his or her decision 24 hours later after reading the full consent form. The participation rate improved 145% over that of an earlier feasibility study where the recruitment rate was 22%. Most participants stated that the flip chart was helpful and informative and that the photographs were effective in communicating the purpose of the study. Participation rates could be enhanced in future clinical trials by using a visual presentation to explain and describe the study as part of the informed consent process. More research is needed to test alternate methods of obtaining informed consent.

Corporal Punishment: Facts and Alternatives.

ERIC Educational Resources Information Center

Wilder, Pana

1982-01-01

Suggests that corporal punishment in the schools be abolished and presents alternatives to physical punishment. Proposes educators and other concerned individuals work together to form student problem committees, adjust classroom environment and improve the curriculum, and exercise their legal rights. (JAC)

Multiple forms of statherin in human salivary secretions.

PubMed

Jensen, J L; Lamkin, M S; Troxler, R F; Oppenheim, F G

1991-01-01

Sequential chromatography of hydroxyapatite-adsorbed salivary proteins from submandibular/sublingual secretions on Sephadex G-50 and reversed-phase HPLC resulted in the purification of statherin and several statherin variants. Amino acid analysis, Edman degradation and carboxypeptidase digestion of the obtained protein fractions led to the determination of the complete primary structures of statherin SV1, statherin SV2, and statherin SV3. SV1 is identical to statherin but lacks the carboxyl-terminal phenylalanine residue. SV2, lacking residues 6-15, is otherwise identical to statherin. SV3 is identical to SV2 but lacks the carboxyl-terminal phenylalanine. These results provide the first evidence for multiple forms of statherin which are probably derived both by post-translational modification and alternative splicing of the statherin gene.

Air transportation energy efficiency - Alternatives and implications

NASA Technical Reports Server (NTRS)

Williams, L. J.

1976-01-01

Results from recent studies of air transportation energy efficiency alternatives are discussed, along with some of the implications of these alternatives. The fuel-saving alternatives considered include aircraft operation, aircraft modification, derivative aircraft, and new aircraft. In the near-term, energy efficiency improvements should be possible through small improvements in fuel-saving flight procedures, higher density seating, and higher load factors. Additional small near-term improvements could be obtained through aircraft modifications, such as the relatively inexpensive drag reduction modifications. Derivatives of existing aircraft could meet the requirements for new aircraft and provide energy improvements until advanced technology is available to justify the cost of a completely new design. In order to obtain significant improvements in energy efficiency, new aircraft must truly exploit advanced technology in such areas as aerodynamics, composite structures, active controls, and advanced propulsion.

48 CFR 833.214 - Alternative dispute resolution (ADR).

Code of Federal Regulations, 2011 CFR

2011-10-01

... resolution (ADR). 833.214 Section 833.214 Federal Acquisition Regulations System DEPARTMENT OF VETERANS... Alternative dispute resolution (ADR). Contracting officers and contractors are encouraged to use alternative dispute resolution (ADR) procedures. CBCA guidance on ADR may be obtained at http://www.cbca.gsa.gov. ...

48 CFR 833.214 - Alternative dispute resolution (ADR).

Code of Federal Regulations, 2010 CFR

2010-10-01

... resolution (ADR). 833.214 Section 833.214 Federal Acquisition Regulations System DEPARTMENT OF VETERANS... Alternative dispute resolution (ADR). Contracting officers and contractors are encouraged to use alternative dispute resolution (ADR) procedures. CBCA guidance on ADR may be obtained at http://www.cbca.gsa.gov. ...

From the Lab Bench: Know your alternative feed

USDA-ARS?s Scientific Manuscript database

A column was written to discuss the need to know the nutritive value of the alternative feed (by- or co-product feeds) that you are feeding to your cattle. Alternative feeds can come in different physical forms: being either wet or dry, finely ground, crumbly or pelleted. Distiller’s and brewer’s ...

Alternative, complementary and traditional medicine in Malaysia.

PubMed

Talib, N

2006-09-01

This paper sets out the practice of traditional, alternative and/or complementary medicine in Malaysia. It gives an overview of the types of alternative medicine available, and the legal regulation, or lack of it within the current setting. The relevant policies and governmental action in this area are highlighted. Relevant case law decisions in this area are also included. The practice of spiritual healing as one form of traditional medicine, and its role within the spectrum of alternative medicine is dealt with briefly. The significant question of integration of alternative medicine within the existing allopathic system is addressed. The paper concludes that as interest in, and usage of alternative medicine is not likely to decrease, certain measures must be taken by the relevant authorities to ensure among others, the safety and efficacy of these medicines.

An Examination of Test-Retest, Alternate Form Reliability, and Generalizability Theory Study of the easyCBM Word and Passage Reading Fluency Assessments: Grade 3. Technical Report #1218

ERIC Educational Resources Information Center

Park, Bitnara Jasmine; Anderson, Daniel; Alonzo, Julie; Lai, Cheng-Fei; Tindal, Gerald

2012-01-01

This technical report is one in a series of five describing the reliability (test/retest and alternate form) and G-Theory/D-Study research on the easyCBM reading measures, grades 1-5. Data were gathered in the spring of 2011 from a convenience sample of students nested within classrooms at a medium-sized school district in the Pacific Northwest.…

Special Section: Complementary and Alternative Medicine (CAM): Time to Talk

MedlinePlus

... with your health care providers any complementary and alternative medicines you take or are thinking about starting. Photo: ... and older use some form of complementary and alternative medicine (CAM). But less than one-third who use ...

Constraints on the ωπ Form Factor from Analyticity and Unitarity

NASA Astrophysics Data System (ADS)

Ananthanarayan, B.; Caprini, Irinel; Kubis, Bastian

Form factors are important low-energy quantities and an accurate knowledge of these sheds light on the strong interactions. A variety of methods based on general principles have been developed to use information known in different energy regimes to constrain them in regions where experimental information needs to be tested precisely. Here we review our recent work on the electromagnetic ωπ form factor in a model-independent framework known as the method of unitarity bounds, partly motivated by the discre-pancies noted recently between the theoretical calculations of the form factor based on dispersion relations and certain experimental data measured from the decay ω → π0γ*. We have applied a modified dispersive formalism, which uses as input the discontinuity of the ωπ form factor calculated by unitarity below the ωπ threshold and an integral constraint on the square of its modulus above this threshold. The latter constraint was obtained by exploiting unitarity and the positivity of the spectral function of a QCD correlator, computed on the spacelike axis by operator product expansion and perturbative QCD. An alternative constraint is obtained by using data available at higher energies for evaluating an integral of the modulus squared with a suitable weight function. From these conditions we derived upper and lower bounds on the modulus of the ωπ form factor in the region below the ωπ threshold. The results confirm the existence of a disagreement between dispersion theory and experimental data on the ωπ form factor around 0:6 GeV, including those from NA60 published in 2016.

Constraints on the ωπ form factor from analyticity and unitarity

NASA Astrophysics Data System (ADS)

Ananthanarayan, B.; Caprini, Irinel; Kubis, Bastian

2016-05-01

Form factors are important low-energy quantities and an accurate knowledge of these sheds light on the strong interactions. A variety of methods based on general principles have been developed to use information known in different energy regimes to constrain them in regions where experimental information needs to be tested precisely. Here we review our recent work on the electromagnetic ωπ form factor in a model-independent framework known as the method of unitarity bounds, partly motivated by the discrepancies noted recently between the theoretical calculations of the form factor based on dispersion relations and certain experimental data measured from the decay ω → π0γ∗. We have applied a modified dispersive formalism, which uses as input the discontinuity of the ωπ form factor calculated by unitarity below the ωπ threshold and an integral constraint on the square of its modulus above this threshold. The latter constraint was obtained by exploiting unitarity and the positivity of the spectral function of a QCD correlator, computed on the spacelike axis by operator product expansion and perturbative QCD. An alternative constraint is obtained by using data available at higher energies for evaluating an integral of the modulus squared with a suitable weight function. From these conditions we derived upper and lower bounds on the modulus of the ωπ form factor in the region below the ωπ threshold. The results confirm the existence of a disagreement between dispersion theory and experimental data on the ωπ form factor around 0.6 GeV, including those from NA60 published in 2016.

Subject-specific pedagogical content knowledge: Implications for alternatively and traditionally trained biology teachers

NASA Astrophysics Data System (ADS)

Ravgiala, Rebekah Rae

Theories regarding the development of expertise hold implications for alternative and traditional certification programs and the teachers they train. The literature suggests that when compared to experts in the field of teaching, the behaviors of novices differ in ways that are directly attributed to their pedagogical content knowledge. However, few studies have examined how first and second year biology teachers entering the profession from traditional and alternative training differ in their demonstration of subject-specific pedagogical content knowledge. The research problem in this multicase, naturalistic inquiry investigated how subject-specific pedagogical content knowledge was manifested among first and second year biology teachers in the task of transforming subject matter into forms that are potentially meaningful to students when explicit formal training has been and has not been imparted to them as preservice teachers. Two first year and two second year biology teachers were the subjects of this investigation. Allen and Amber obtained their certification through an alternative summer training institute in consecutive years. Tiffany and Tricia obtained their certification through a traditional, graduate level training program in consecutive years. Both programs were offered at the same northeastern state university. Participants contributed to six data gathering techniques including an initial semi-structured interview, responses to the Conceptions of Teaching Science questionnaire (Hewson & Hewson, 1989), three videotaped biology lessons, evaluation of three corresponding lesson plans, and a final semi-structured interview conducted at the end of the investigation. An informal, end-of-study survey intended to offer participants an opportunity to disclose their thoughts and needs as first year teachers was also employed. Results indicate that while conceptions of teaching science may vary slightly among participants, there is no evidence to suggest that

Biased predecisional processing of leading and nonleading alternatives.

PubMed

Blanchard, Simon J; Carlson, Kurt A; Meloy, Margaret G

2014-03-01

When people obtain information about choice alternatives in a set one attribute at a time, they rapidly identify a leading alternative. Although previous research has established that people then distort incoming information, it is unclear whether distortion occurs through favoring of the leading alternative, disfavoring of the trailing alternative, or both. Prior examinations have not explored the predecisional treatment of the nonleading alternative (or alternatives) because they conceptualized distortion as a singular construct in binary choice and measured it using a relative item comparing the evaluation of both alternatives simultaneously. In this article, we introduce a measure of distortion at the level of the alternative, which allows for measuring whether predecisional distortion favors or disfavors every alternative being considered in choice sets of various sizes. We report that both proleader and antitrailer distortion occur and that the use of antitrailer processing differs between binary choices and multiple-options choices.

Prosthetic misfit of implant-supported prosthesis obtained by an alternative section method

PubMed Central

Falcão-Filho, Hilmo Barreto Leite; de Aguiar, Fábio Afrânio; Rodrigues, Renata Cristina Silveira; de Mattos, Maria da Gloria Chiarello; Ribeiro, Ricardo Faria

2012-01-01

PURPOSE Adequate passive-fitting of one-piece cast 3-element implant-supported frameworks is hard to achieve. This short communication aims to present an alternative method for section of one-piece cast frameworks and for casting implant-supported frameworks. MATERIALS AND METHODS Three-unit implant-supported nickel-chromium (Ni-Cr) frameworks were tested for vertical misfit (n = 6). The frameworks were cast as one-piece (Group A) and later transversally sectioned through a diagonal axis (Group B) and compared to frameworks that were cast diagonally separated (Group C). All separated frameworks were laser welded. Only one side of the frameworks was screwed. RESULTS The results on the tightened side were significantly lower in Group C (6.43 ± 3.24 µm) when compared to Groups A (16.50 ± 7.55 µm) and B (16.27 ± 1.71 µm) (P<.05). On the opposite side, the diagonal section of the one-piece castings for laser welding showed significant improvement in the levels of misfit of the frameworks (Group A, 58.66±14.30 µm; Group B, 39.48±12.03 µm; Group C, 23.13±8.24 µm) (P<.05). CONCLUSION Casting diagonally sectioned frameworks lowers the misfit levels. Lower misfit levels for the frameworks can be achieved by diagonally sectioning one-piece frameworks. PMID:22737313

30 CFR 47.43 - Label alternatives.

Code of Federal Regulations, 2010 CFR

2010-07-01

... COMMUNICATION (HazCom) Container Labels and Other Forms of Warning § 47.43 Label alternatives. The operator may... container to which it applies, (b) Communicates the same information as required on the label, and (c) Is...

Niobium superconducting rf cavity fabrication by electrohydraulic forming

NASA Astrophysics Data System (ADS)

Cantergiani, E.; Atieh, S.; Léaux, F.; Perez Fontenla, A. T.; Prunet, S.; Dufay-Chanat, L.; Koettig, T.; Bertinelli, F.; Capatina, O.; Favre, G.; Gerigk, F.; Jeanson, A. C.; Fuzeau, J.; Avrillaud, G.; Alleman, D.; Bonafe, J.; Marty, P.

2016-11-01

Superconducting rf (SRF) cavities are traditionally fabricated from superconducting material sheets or made of copper coated with superconducting material, followed by trim machining and electron-beam welding. An alternative technique to traditional shaping methods, such as deep-drawing and spinning, is electrohydraulic forming (EHF). In EHF, half-cells are obtained through ultrahigh-speed deformation of blank sheets, using shockwaves induced in water by a pulsed electrical discharge. With respect to traditional methods, such a highly dynamic process can yield interesting results in terms of effectiveness, repeatability, final shape precision, higher formability, and reduced springback. In this paper, the first results of EHF on high purity niobium are presented and discussed. The simulations performed in order to master the multiphysics phenomena of EHF and to adjust its process parameters are presented. The microstructures of niobium half-cells produced by EHF and by spinning have been compared in terms of damage created in the material during the forming operation. The damage was assessed through hardness measurements, residual resistivity ratio (RRR) measurements, and electron backscattered diffraction analyses. It was found that EHF does not worsen the damage of the material during forming and instead, some areas of the half-cell have shown lower damage compared to spinning. Moreover, EHF is particularly advantageous to reduce the forming time, preserve roughness, and to meet the final required shape accuracy.

Crystal-contact engineering to obtain a crystal form of the Kelch domain of human Keap1 suitable for ligand-soaking experiments.

PubMed

Hörer, Stefan; Reinert, Dirk; Ostmann, Katja; Hoevels, Yvette; Nar, Herbert

2013-06-01

Keap1 is a substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex and plays an important role in the cellular response to oxidative stress. It binds Nrf2 with its Kelch domain and thus triggers the ubiquitinylation and degradation of Nrf2. Oxidative stress prevents the degradation of Nrf2 and leads to the activation of cytoprotective genes. Therefore, Keap1 is an attractive drug target in inflammatory diseases. The support of a medicinal chemistry effort by structural research requires a robust crystallization system in which the crystals are preferably suited for performing soaking experiments. This facilitates the generation of protein-ligand complexes in a routine and high-throughput manner. The structure of human Keap1 has been described previously. In this crystal form, however, the binding site for Nrf2 was blocked by a crystal contact. This interaction was analysed and mutations were introduced to disrupt this crystal contact. One double mutation (E540A/E542A) crystallized in a new crystal form in which the binding site for Nrf2 was not blocked and was accessible to small-molecule ligands. The crystal structures of the apo form of the mutated Keap1 Kelch domain (1.98 Å resolution) and of the complex with an Nrf2-derived peptide obtained by soaking (2.20 Å resolution) are reported.

Massage Acupuncture, Moxibustion, and Other Forms of Complementary and Alternative Medicine in Inflammatory Bowel Disease.

PubMed

Stein, Daniel J

2017-12-01

Complementary and alternative medicine is frequently used by inflammatory bowel disease (IBD) patients; most common are massage, acupuncture, and moxibustion therapy. Massage therapy is poorly studied in IBD patients; therefore, its benefits remain unknown. Acupuncture and moxibustion therapy have been shown to improve inflammation and symptoms in animal and human studies. However, current clinical trials of acupuncture and moxibustion are of insufficient quality to recommend them as alternative therapy. Nonetheless, because these therapies seem generally to be safe, they may have a role as complementary to conventional therapy. Copyright © 2017 Elsevier Inc. All rights reserved.

Barriers to College Students Learning How Rocks Form

ERIC Educational Resources Information Center

Kortz, Karen M.; Murray, Daniel P.

2009-01-01

Students do not have a good understanding of how rocks form. Instead, they have many non-scientific alternative conceptions to explain different aspects of rock formation. Using 10 interviews and nearly 200 questionnaires filled out by students at four different colleges, we identified many alternative conceptions students have about rock…

Cypriot nurses' knowledge and attitudes towards alternative medicine.

PubMed

Zoe, Roupa; Charalambous, Charalambos; Popi, Sotiropoulou; Maria, Rekleiti; Aris, Vasilopoulos; Agoritsa, Koulouri; Evangelia, Kotrotsiou

2014-02-01

To investigate Cypriot nurses' knowledge and attitude towards alternative treatments. Two hundred randomly selected registered Nurses from public hospitals in Cyprus were administered an anonymous self-report questionnaire with closed-type questions. The particular questionnaire has previously been used in similar surveys. Six questions referred to demographic data and 14 questions to attitudes and knowledge towards alternative medicine. One hundred and thirty-eight questionnaires were adequately completed and evaluated. Descriptive and inferential statistics was performed. SPSS 17.0 was used. Statistical significance was set at p < 0.05. Over 1/3 of our sample nurses reported that they had turned to some form of alternative treatment at some point in their lives in order to deal with a certain medical situation. Most of these nurses who reported some knowledge on specific alternative treatment methods, (75.9%) also reported using such methods within their clinical practice. The nurses who had received some form of alternative treatment reported using them more often in their clinical practice, in comparison to those who had never received such treatment (Mann-Whitney U = 1137, p = 0.006). The more frequently nurses used alternative treatment in their clinical practice, the more interested they got in expanding their knowledge on the subject (Pearson's r = 0.250, p = 0.006). Most nurses are familiar with alternative medicine and interested in expanding their knowledge on subject, despite the fact that they do not usually practice it. Special education and training as well as legislative actions are necessary for alternative medicine to be broadly accepted. Copyright © 2013 Elsevier Ltd. All rights reserved.

Method of Obtaining Uniform Coatings on Graphite

DOEpatents

Campbell, I. E.

1961-04-01

A method is given for obtaining uniform carbide coatings on graphite bodies. According to the invention a metallic halide in vapor form is passed over the graphite body under such conditions of temperature and pressure that the halide reacts with the graphite to form a coating of the metal carbide on the surface of the graphite.

METHOD OF OBTAINING UNIFORM COATINGS ON GRAPHITE

DOEpatents

Campbell, I.E.

1961-04-01

A method is given for obtaining uniform carbide coatings on graphite bodies. According to the invention a metallic halide in vapor form is passed over the graphite body under such conditions of temperature and pressure that the halide reacts with the graphite to form a coating of the metal carbide on the surface of the graphite.

The Evaluation of Cone Capsule as an Alternative Hull form for Portable Tsunami Lifeboat to Support Evacuation System in the Coastal Regions and Small Islands

NASA Astrophysics Data System (ADS)

Fauzan Zakki, Ahmad; Suharto; Windyandari, Aulia

2018-03-01

Several attempts have been made to reduce the risk of tsunami disasters such as the development of early warning systems, evacuation procedures training, coastal protection and coastal spatial planning. Although many efforts to mitigate the impact of the tsunami in Indonesia was made, no one has developed a portable disaster rescue vehicle/shelter as well as a lifeboat on ships and offshore building, which is always available when a disaster occurs. The aim of the paper is to evaluate the performance of cone capsule shaped hull form that would be used for the portable tsunami lifeboat. The investigation of the boat resistance, intact stability, and seakeeping characteristics was made. The numerical analysis results indicate that the cone capsule is reliable as an alternative hull form for the portable tsunami lifeboat.

Ordered alternating binary polymer nanodroplet array by sequential spin dewetting.

PubMed

Bhandaru, Nandini; Das, Anuja; Salunke, Namrata; Mukherjee, Rabibrata

2014-12-10

We report a facile technique for fabricating an ordered array of nearly equal-sized mesoscale polymer droplets of two constituent polymers (polystyrene, PS and poly(methyl methacrylate), PMMA) arranged in an alternating manner on a topographically patterned substrate. The self-organized array of binary polymers is realized by sequential spin dewetting. First, a dilute solution of PMMA is spin-dewetted on a patterned substrate, resulting in an array of isolated PMMA droplets arranged along the substrate grooves due to self-organization during spin coating itself. The sample is then silanized with octadecyltrichlorosilane (OTS), and subsequently, a dilute solution of PS is spin-coated on to it, which also undergoes spin dewetting. The spin-dewetted PS drops having a size nearly equal to the pre-existing PMMA droplets position themselves between two adjacent PMMA drops under appropriate conditions, forming an alternating binary polymer droplet array. The alternating array formation takes place for a narrow range of solution concentration for both the polymers and depends on the geometry of the substrate. The size of the droplets depends on the extent of confinement, and droplets as small as 100 nm can be obtained by this method, on a suitable template. The findings open up the possibility of creating novel surfaces having ordered multimaterial domains with a potential multifunctional capability.

7 CFR 1205.520 - Procedure for obtaining reimbursement.

Code of Federal Regulations, 2010 CFR

2010-01-01

... application forms may be filed. In any such case, the reimbursement application shall show the names... Cotton Board shall make reimbursement to the importer. For joint applications, the reimbursement shall be... procedures prescribed in this section. (a) Application form. An importer shall obtain a reimbursement...

Plain Talk about Alternative Assessment.

ERIC Educational Resources Information Center

Cheek, Dennis W.

1993-01-01

Testing is a technology, a socially mediated, value-laden endeavor. Technologies embody trade-offs between what is desired and real-world constraints of cost, time, thought, and energy. Although alternative assessments offer exciting prospects for middle schools, these new forms must not be misused or naively accepted as defensible, consummate…

40 CFR 86.080-12 - Alternative certification procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., Liquefied Petroleum Gas-Fueled and Methanol-Fueled Heavy-Duty Vehicles § 86.080-12 Alternative certification... are obtained under the abbreviated certification review procedure. (vii) Upon completing all... for certification, test reports and data submitted by the manufacturer, data obtained during an...

40 CFR 86.080-12 - Alternative certification procedures.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., Liquefied Petroleum Gas-Fueled and Methanol-Fueled Heavy-Duty Vehicles § 86.080-12 Alternative certification... are obtained under the abbreviated certification review procedure. (vii) Upon completing all... for certification, test reports and data submitted by the manufacturer, data obtained during an...

Alternative Fuels Data Center

Science.gov Websites

, certain buses, or commercial vehicles that are powered by an alternative fuel, if the vehicles obtain an (GVW) Type of Vehicle Decal Fee 18,000 pounds (lbs.) or less Passenger, School Bus, or Commercial $75 vehicles, buses, or commercial motor vehicles that are powered by compressed natural gas (CNG), liquefied

[Alternative treatments in irritable bowel syndrome].

PubMed

Hagège, H

2009-02-01

Managing irritable bowel syndrome (IBS) is difficult and often a source of dissatisfaction for the patient, explaining the increasingly frequent recourse to alternative treatments. These highly varied treatments are often associated. They can be classed into four categories: reflexology methods, interventions on the psyche, biological therapies, and treatments using certain forms of energy. Although some studies show interesting results, currently there are not sufficient scientific arguments to recommend one or another of these alternative treatments. Multicenter controlled studies are needed to better evaluate the strategies that appear to be cost-effective.

Not Just Another Alternative School

ERIC Educational Resources Information Center

Gulson, Kalervo N.; Webb, P. Taylor

2016-01-01

In this article, we problematize the establishment of an Africentric Alternative School in Toronto, Canada. We argue that policy, and race and racializations cannot be understood outside of, or immune to, neoliberalism. We contend that policy is a form of racial biopolitics, and race is now produced through neoliberal markets, in conjunction with…

Alternate Reality Games as Learning Environments for Student Induction

ERIC Educational Resources Information Center

Whitton, Nicola; Jones, Rosie; Wilson, Scott; Whitton, Peter

2014-01-01

Alternate reality games (ARGs) are a relatively new form of collaborative game that make use of both the virtual and real worlds to engage players in a series of challenges within a compelling narrative. The Alternate Reality Games for Orientation, Socialisation and Induction (ARGOSI) project aimed to use this game format to provide an alternative…

46 CFR 502.411 - Mediation and other alternative means of dispute resolution.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 9 2010-10-01 2010-10-01 false Mediation and other alternative means of dispute... PROVISIONS RULES OF PRACTICE AND PROCEDURE Alternative Dispute Resolution § 502.411 Mediation and other alternative means of dispute resolution. (a) Parties are encouraged to utilize mediation or other forms of...

Alternative Action Organizations: Social Solidarity or Political Advocacy?

PubMed Central

Grasso, Maria

2018-01-01

This article investigates the involvement of alternative action organizations in three forms of political advocacy in an attempt to gauge their degree of politicization. These forms can be understood as representing three different ways of making political claims: by raising public awareness with respect to a given cause or issue, by trying to influence the policy maker through “insider” lobbying activities, and by protesting in the streets as “outsiders.” Our findings show strong cross-national variations in all three forms of political activities, although not always following a consistent pattern. They also suggest that there is a relationship between the severity of the economic crisis and the form of advocacy. Most important, our analysis suggests that the politicization of alternative action organizations depends both on certain internal characteristics such as their degree of formalization and professionalization, as well as their thematic focus, and the scope of their activities, and on the broader context in terms of economic crisis, austerity policies, and political opportunities. As regards the latter, we find an impact especially on lobbying and protesting. PMID:29899575

Techniques for obtaining subjective response to vertical vibration

NASA Technical Reports Server (NTRS)

Clarke, M. J.; Oborne, D. J.

1975-01-01

Laboratory experiments were performed to validate the techniques used for obtaining ratings in the field surveys carried out by the University College of Swansea. In addition, attempts were made to evaluate the basic form of the human response to vibration. Some of the results obtained by different methods are described.

What controls channel form in steep mountain streams?

NASA Astrophysics Data System (ADS)

Palucis, M. C.; Lamb, M. P.

2017-07-01

Steep mountain streams have channel morphologies that transition from alternate bar to step-pool to cascade with increasing bed slope, which affect stream habitat, flow resistance, and sediment transport. Experimental and theoretical studies suggest that alternate bars form under large channel width-to-depth ratios, step-pools form in near supercritical flow or when channel width is narrow compared to bed grain size, and cascade morphology is related to debris flows. However, the connection between these process variables and bed slope—the apparent dominant variable for natural stream types—is unclear. Combining field data and theory, we find that certain bed slopes have unique channel morphologies because the process variables covary systematically with bed slope. Multiple stable states are predicted for other ranges in bed slope, suggesting that a competition of underlying processes leads to the emergence of the most stable channel form.

Comparison of oil removal in surfactant alternating gas with water alternating gas, water flooding and gas flooding in secondary oil recovery process.

PubMed

Salehi, Mehdi Mohammad; Safarzadeh, Mohammad Amin; Sahraei, Eghbal; Nejad, Seyyed Alireza Tabatabaei

2014-08-01

Growing oil prices coupled with large amounts of residual oil after operating common enhanced oil recovery methods has made using methods with higher operational cost economically feasible. Nitrogen is one of the gases used in both miscible and immiscible gas injection process in oil reservoir. In heterogeneous formations gas tends to breakthrough early in production wells due to overriding, fingering and channeling. Surfactant alternating gas (SAG) injection is one of the methods commonly used to decrease this problem. Foam which is formed on the contact of nitrogen and surfactant increases viscosity of injected gas. This increases the oil-gas contact and sweep efficiency, although adsorption of surfactant on rock surface can causes difficulties and increases costs of process. Many parameters must be considered in design of SAG process. One of the most important parameters is SAG ratio that should be in optimum value to improve the flooding efficiency. In this study, initially the concentration of surfactant was optimized due to minimization of adsorption on rock surface which results in lower cost of surfactant. So, different sodium dodecyl sulfate (SDS) concentrations of 100, 500, 1000, 2000, 3000 and 4000 ppm were used to obtain the optimum concentration at 70 °C and 144.74×10 5  Pa. A simple, clean and relatively fast spectrophotometric method was used for determination of surfactant which is based on the formation of an ion-pair. Then the effect of surfactant to gas volume ratio on oil recovery in secondary oil recovery process during execution of immiscible surfactant alternating gas injection was examined experimentally. The experiments were performed with sand pack under certain temperature, pressure and constant rate. Experiments were performed with surfactant to gas ratio of 1:1, 1:2, 1:3, 2:1 and 3:1 and 1.2 pore volume injected. Then, comparisons were made between obtained results (SAG) with water flooding, gas flooding and water alternating gas

Alternative Internal Standard Calibration of an Indirect Enzymatic Analytical Method for 2-MCPD Fatty Acid Esters.

PubMed

Koyama, Kazuo; Miyazaki, Kinuko; Abe, Kousuke; Egawa, Yoshitsugu; Fukazawa, Toru; Kitta, Tadashi; Miyashita, Takashi; Nezu, Toru; Nohara, Hidenori; Sano, Takashi; Takahashi, Yukinari; Taniguchi, Hideji; Yada, Hiroshi; Yamazaki, Kumiko; Watanabe, Yomi

2017-06-01

An indirect enzymatic analysis method for the quantification of fatty acid esters of 2-/3-monochloro-1,2-propanediol (2/3-MCPD) and glycidol was developed, using the deuterated internal standard of each free-form component. A statistical method for calibration and quantification of 2-MCPD-d 5 , which is difficult to obtain, is substituted by 3-MCPD-d 5 used for calculation of 3-MCPD. Using data from a previous collaborative study, the current method for the determination of 2-MCPD content using 2-MCPD-d 5 was compared to three alternative new methods using 3-MCPD-d 5 . The regression analysis showed that the alternative methods were unbiased compared to the current method. The relative standard deviation (RSD R ) among the testing laboratories was ≤ 15% and the Horwitz ratio was ≤ 1.0, a satisfactory value.

Effect of alternative glycosylation on insulin receptor processing.

PubMed

Hwang, J B; Frost, S C

1999-08-06

The mature insulin receptor is a cell surface heterotetrameric glycoprotein composed of two alpha- and two beta-subunits. In 3T3-L1 adipocytes as in other cell types, the receptor is synthesized as a single polypeptide consisting of uncleaved alpha- and beta-subunits, migrating as a 190-kDa glycoprotein. To examine the importance of N-linked glycosylation on insulin receptor processing, we have used glucose deprivation as a tool to alter protein glycosylation. Western blot analysis shows that glucose deprivation led to a time-dependent accumulation of an alternative proreceptor of 170 kDa in a subcellular fraction consistent with endoplasmic reticulum localization. Co-precipitation assays provide evidence that the alternative proreceptor bound GRP78, an endoplasmic reticulum molecular chaperone. N-Glycosidase F treatment shows that the alternative proreceptor contained N-linked oligosaccharides. Yet, endoglycosidase H insensitivity indicates an aberrant oligosaccharide structure. Using pulse-chase methodology, we show that the synthetic rate was similar between the normal and alternative proreceptor. However, the normal proreceptor was processed into alpha- and beta-subunits (t((1)/(2)) = 1.3 +/- 0.6 h), while the alternative proreceptor was degraded (t((1)/(2)) = 5.1 +/- 0.6 h). Upon refeeding cells that were initially deprived of glucose, the alternative proreceptor was processed to a higher molecular weight form and gained sensitivity to endoglycosidase H. This "intermediate" form of the proreceptor was also degraded, although a small fraction escaped degradation, resulting in cleavage to the alpha- and beta-subunits. These data provide evidence for the first time that glucose deprivation leads to the accumulation of an alternative proreceptor, which can be post-translationally glycosylated with the readdition of glucose inducing both accelerated degradation and maturation.

path integral approach to closed form pricing formulas in the Heston framework.

NASA Astrophysics Data System (ADS)

Lemmens, Damiaan; Wouters, Michiel; Tempere, Jacques; Foulon, Sven

2008-03-01

We present a path integral approach for finding closed form formulas for option prices in the framework of the Heston model. The first model for determining option prices was the Black-Scholes model, which assumed that the logreturn followed a Wiener process with a given drift and constant volatility. To provide a realistic description of the market, the Black-Scholes results must be extended to include stochastic volatility. This is achieved by the Heston model, which assumes that the volatility follows a mean reverting square root process. Current applications of the Heston model are hampered by the unavailability of fast numerical methods, due to a lack of closed-form formulae. Therefore the search for closed form solutions is an essential step before the qualitatively better stochastic volatility models will be used in practice. To attain this goal we outline a simplified path integral approach yielding straightforward results for vanilla Heston options with correlation. Extensions to barrier options and other path-dependent option are discussed, and the new derivation is compared to existing results obtained from alternative path-integral approaches (Dragulescu, Kleinert).

Alternative strategies: a better alternative.

PubMed

Doody, Dennis

2010-05-01

Alternatives can be defined as being any financial asset other than traditional stocks and bonds. They include marketable alternatives, private capital, and equity real estate. There are two primary reasons for investing in alternatives: the potential for greater return and the opportunity to diversify a portfolio. Although alternatives were challenged in the highly volatile environment that existed in 2008 and early 2009, they generally lived up to expectations.

Estimation of nitrate and nitrogen forms of vegetables by UV-spectrophotometry after photo-oxydation.

PubMed

Ribeiro, T; Depres, S; Couteau, G; Pauss, A

2003-01-01

An alternative method for the estimation of nitrate and nitrogen forms in vegetables is proposed. Nitrate can be directly estimated by UV-spectrophotometry after an extraction step with water. The other nitrogen compounds are photo-oxidized into nitrate, and then estimated by UV-spectrophotometry. An oxidative solution of sodium persulfate and a Hg-UV lamp is used. Preliminary assays were realized with vegetables like salade, spinachs, artichokes, small peas, broccolis, carrots, watercress; acceptable correlations between expected and experimental values of nitrate amounts were obtained, while the detection limit needs to be lowered. The optimization of the method is underway.

Application of alternative fixatives to formalin in diagnostic pathology

PubMed Central

Gatta, L. Benerini; Cadei, M.; Balzarini, P.; Castriciano, S.; Paroni, R.; Verzeletti, A.; Cortellini, V.; De Ferrari, F.; Grigolato, P.

2012-01-01

Fixation is a critical step in the preparation of tissues for histopathology. The aim of this study was to investigate the effects of different fixatives vs formalin on proteins and DNA, and to evaluate alternative fixation for morphological diagnosis and nucleic acid preservation for molecular methods. Forty tissues were fixed for 24 h with six different fixatives: the gold standard fixative formalin, the historical fixatives Bouin and Hollande, and the alternative fixatives Greenfix, UPM and CyMol. Tissues were stained (Haematoxylin-Eosin, Periodic Acid Schiff, Trichromic, Alcian-blue, High Iron Diamine stainings), and their antigenicity was determined by immunohistochemistry (performed with PAN-CK, CD31, Ki-67, S100, CD68, AML antibodies). DNA extraction, KRAS sequencing, FISH for CEP-17, and flow cytometry analysis of nuclear DNA content were applied. For cell morphology the alternative fixatives (Greenfix, UPM, CyMol) were equivalent to formalin. As expected, Hollande proved to be the best fixative for morphology. The morphology obtained with Bouin was comparable to the one with formalin. Hollande was the best fixative for histochemistry. Bouin proved to be equivalent to formalin. The alternative fixatives were equivalent to formalin, although with greater variability in haematoxylin-eosin staining. It proved the possibility to obtain immunohistochemical staining largely equivalent to that following formalin-fixation with the following fixatives: Greenfix, Hollande, UPM and CyMol. The tissues fixed in Bouin did not provide results comparable to those obtained with formalin. The DNA extracted from samples fixed with alternative fixatives was found to be suitable for molecular analysis. PMID:22688293

Computational alternatives to obtain time optimal jet engine control. M.S. Thesis

NASA Technical Reports Server (NTRS)

Basso, R. J.; Leake, R. J.

1976-01-01

Two computational methods to determine an open loop time optimal control sequence for a simple single spool turbojet engine are described by a set of nonlinear differential equations. Both methods are modifications of widely accepted algorithms which can solve fixed time unconstrained optimal control problems with a free right end. Constrained problems to be considered have fixed right ends and free time. Dynamic programming is defined on a standard problem and it yields a successive approximation solution to the time optimal problem of interest. A feedback control law is obtained and it is then used to determine the corresponding open loop control sequence. The Fletcher-Reeves conjugate gradient method has been selected for adaptation to solve a nonlinear optimal control problem with state variable and control constraints.

Alternative Fuels Data Center

Science.gov Websites

Alternative Fuel Tax Rates A special excise tax rate of 2% is imposed on the sale of propane and an excise tax of $0.23 per gallon is imposed on all special fuels sales and deliveries, including compressed of CNG or 1.7 gallons of LNG. Retailers must obtain a license from the Office of the State Tax

Identification of Alternative Splice Variants Using Unique Tryptic Peptide Sequences for Database Searches.

PubMed

Tran, Trung T; Bollineni, Ravi C; Strozynski, Margarita; Koehler, Christian J; Thiede, Bernd

2017-07-07

Alternative splicing is a mechanism in eukaryotes by which different forms of mRNAs are generated from the same gene. Identification of alternative splice variants requires the identification of peptides specific for alternative splice forms. For this purpose, we generated a human database that contains only unique tryptic peptides specific for alternative splice forms from Swiss-Prot entries. Using this database allows an easy access to splice variant-specific peptide sequences that match to MS data. Furthermore, we combined this database without alternative splice variant-1-specific peptides with human Swiss-Prot. This combined database can be used as a general database for searching of LC-MS data. LC-MS data derived from in-solution digests of two different cell lines (LNCaP, HeLa) and phosphoproteomics studies were analyzed using these two databases. Several nonalternative splice variant-1-specific peptides were found in both cell lines, and some of them seemed to be cell-line-specific. Control and apoptotic phosphoproteomes from Jurkat T cells revealed several nonalternative splice variant-1-specific peptides, and some of them showed clear quantitative differences between the two states.

Obtaining alternative fuel from sweet sorghum in the conditions of the Republic of Tatarstan

NASA Astrophysics Data System (ADS)

Kashapov, N. F.; Nafikov, M. M.; Gilmanshin, I. R.; Nigmatzyanov, A. R.

2017-09-01

In the agro-industrial complex of the Russian Federation the main types of energy resources is the FCM (fuel-lubricating materials), electricity, coal and gas. Priority energy is determined depending on the orientation of the activity of the agricultural enterprise. In the cost of getting products one of the key factors is its energy intensity. Under the energy intensity means the amount of energy expended per unit of finished product. Domestic manufacturers lag behind on this indicator from their foreign colleagues. Greatly influenced by the climatic conditions of production, which affects the amount of energy expended annually becoming more expensive. In the article, the authors address a topical issue of renewable(alternative) fuels from sweet sorghum in the stems of which contains from 14 to 21 % sugar. In the Republic of Tatarstan tested and introduced varieties of sweet sorghum. On the basis of literary data and carried out their own research given a set of equipment and presents non-waste production chain of biodiesel and fuel pellets from stems of sweet sorghum.

Low Voltage Electrolytic Capacitor Pulse Forming Inductive Network for Electric Weapons

DTIC Science & Technology

2006-06-01

reliable high- current, high-energy pulses of many megawatts. Pulsed alternators potentially have the same maintenance issues as other motor ...high-energy pulses of many megawatts. Pulsed alternators potentially have the same maintenance issues as other motor -generator sets, so a solid...Rotating Flywheel) Pulse Forming Network Compensated Pulsed Alternators, or Compulsators as they are called, are essentially large motor -generator

Beta structures of alternating polypeptides and their possible prebiotic significance

NASA Technical Reports Server (NTRS)

Brack, A.; Orgel, L. E.

1975-01-01

A survey of the commonest amino acids formed in prebiotic conditions suggests that the earliest form of genetic coding may have specified polypeptides with a strong tendency to form stable beta-sheet structures. Poly(Val-Lys), like other polypeptides in which hydrophobic and hydrophilic residues alternate, tends to form beta structures. It is shown that bilayers with a hydrophobic interior and a hydrophilic exterior may be present in aqueous solution.

46 CFR 308.548 - Standard form of underwriting agency agreement for cargo, Form MA-318.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., Form MA-318. 308.548 Section 308.548 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iv-General § 308.548 Standard form of underwriting agency agreement for cargo, Form MA-318. This form, which may be obtained from the American War...

46 CFR 308.548 - Standard form of underwriting agency agreement for cargo, Form MA-318.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., Form MA-318. 308.548 Section 308.548 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iv-General § 308.548 Standard form of underwriting agency agreement for cargo, Form MA-318. This form, which may be obtained from the American War...

46 CFR 308.548 - Standard form of underwriting agency agreement for cargo, Form MA-318.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., Form MA-318. 308.548 Section 308.548 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iv-General § 308.548 Standard form of underwriting agency agreement for cargo, Form MA-318. This form, which may be obtained from the American War...

46 CFR 308.548 - Standard form of underwriting agency agreement for cargo, Form MA-318.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., Form MA-318. 308.548 Section 308.548 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iv-General § 308.548 Standard form of underwriting agency agreement for cargo, Form MA-318. This form, which may be obtained from the American War...

Alternation as a form of allocation for quality improvement studies in primary healthcare settings: the on-off study design.

PubMed

Mathe, Nonsikelelo; Johnson, Steven T; Wozniak, Lisa A; Majumdar, Sumit R; Johnson, Jeffrey A

2015-08-25

Randomized controlled trials are considered the "gold standard" for scientific rigor in the assessment of benefits and harms of interventions in healthcare. They may not always be feasible, however, when evaluating quality improvement interventions in real-world healthcare settings. Non-randomized controlled trials (NCTs) are designed to answer questions of effectiveness of interventions in routine clinical practice to inform a decision or process. The on-off NCT design is a relatively new design where participant allocation is by alternation. In alternation, eligible patients are allocated to the intervention "on" or control "off " groups in time series dependent sequential clusters. We used two quality improvement studies undertaken in a Canadian primary care setting to illustrate the features of the on-off design. We also explored the perceptions and experiences of healthcare providers tasked with implementing the on-off study design. The on-off design successfully allocated patients to intervention and control groups. Imbalances between baseline variables were attributed to chance, with no detectable biases. However, healthcare providers' perspectives and experiences with the design in practice reveal some conflict. Specifically, providers described the process of allocating patients to the off group as unethical and immoral, feeling it was in direct conflict with their professional principle of providing care for all. The degree of dissatisfaction seemed exacerbated by: 1) the patient population involved (e.g., patient population viewed as high-risk (e.g., depressed or suicidal)), 2) conducting assessments without taking action (e.g., administering the PHQ-9 and not acting on the results), and 3) the (non-blinded) allocation process. Alternation, as in the on-off design, is a credible form of allocation. The conflict reported by healthcare providers in implementing the design, while not unique to the on-off design, may be alleviated by greater emphasis on

Uncertainties in obtaining high reliability from stress-strength models

NASA Technical Reports Server (NTRS)

Neal, Donald M.; Matthews, William T.; Vangel, Mark G.

1992-01-01

There has been a recent interest in determining high statistical reliability in risk assessment of aircraft components. The potential consequences are identified of incorrectly assuming a particular statistical distribution for stress or strength data used in obtaining the high reliability values. The computation of the reliability is defined as the probability of the strength being greater than the stress over the range of stress values. This method is often referred to as the stress-strength model. A sensitivity analysis was performed involving a comparison of reliability results in order to evaluate the effects of assuming specific statistical distributions. Both known population distributions, and those that differed slightly from the known, were considered. Results showed substantial differences in reliability estimates even for almost nondetectable differences in the assumed distributions. These differences represent a potential problem in using the stress-strength model for high reliability computations, since in practice it is impossible to ever know the exact (population) distribution. An alternative reliability computation procedure is examined involving determination of a lower bound on the reliability values using extreme value distributions. This procedure reduces the possibility of obtaining nonconservative reliability estimates. Results indicated the method can provide conservative bounds when computing high reliability. An alternative reliability computation procedure is examined involving determination of a lower bound on the reliability values using extreme value distributions. This procedure reduces the possibility of obtaining nonconservative reliability estimates. Results indicated the method can provide conservative bounds when computing high reliability.

Just the FAQs: An Alternative to Teaching the Research Paper

ERIC Educational Resources Information Center

Strickland, James

2004-01-01

Changing the form of the traditional research paper often results in a greater emphasis on inquiry or FAQ (Frequently Asked Questions). An alternative form of presentation that capitalizes on available technology and requires students to develop their thinking, reading, writing and presentation skills is presented.

Complementary and alternative medicine in women's health. Developing a research agenda.

PubMed

Murphy, P A; Kronenberg, F; Wade, C

1999-01-01

Complementary and alternative medicine is becoming an established intervention modality within the contemporary health care system. Various forms of complementary and alternative medicine are used by patients and practitioners alike, including chiropractic, massage, botanical medicine, homeopathy, and energy therapies. The National Center for Complementary and Alternative Medicine was established within the National Institutes of Health to facilitate evaluation of these alternative therapies, establish an information clearinghouse, and promote research in the field. This article discusses several aspects of complementary and alternative medicine, relates them to women's health, and describes the need for a research agenda to evaluate the impact of the complementary and alternative medicine modalities used for important conditions affecting women.

Paradigm Change: Alternate Approaches to Constitutive and Necking Models for Sheet Metal Forming

NASA Astrophysics Data System (ADS)

Stoughton, Thomas B.; Yoon, Jeong Whan

2011-08-01

This paper reviews recent work proposing paradigm changes for the currently popular approach to constitutive and failure modeling, focusing on the use of non-associated flow rules to enable greater flexibility to capture the anisotropic yield and flow behavior of metals using less complex functions than those needed under associated flow to achieve that same level of fidelity to experiment, and on the use of stress-based metrics to more reliably predict necking limits under complex conditions of non-linear forming. The paper discusses motivating factors and benefits in favor of both associated and non-associated flow models for metal forming, including experimental, theoretical, and practical aspects. This review is followed by a discussion of the topic of the forming limits, the limitations of strain analysis, the evidence in favor of stress analysis, the effects of curvature, bending/unbending cycles, triaxial stress conditions, and the motivation for the development of a new type of forming limit diagram based on the effective plastic strain or equivalent plastic work in combination with a directional parameter that accounts for the current stress condition.

Tissue-specific alternative splicing of TCF7L2

PubMed Central

Prokunina-Olsson, Ludmila; Welch, Cullan; Hansson, Ola; Adhikari, Neeta; Scott, Laura J.; Usher, Nicolle; Tong, Maurine; Sprau, Andrew; Swift, Amy; Bonnycastle, Lori L.; Erdos, Michael R.; He, Zhi; Saxena, Richa; Harmon, Brennan; Kotova, Olga; Hoffman, Eric P.; Altshuler, David; Groop, Leif; Boehnke, Michael; Collins, Francis S.; Hall, Jennifer L.

2009-01-01

Common variants in the transcription factor 7-like 2 (TCF7L2) gene have been identified as the strongest genetic risk factors for type 2 diabetes (T2D). However, the mechanisms by which these non-coding variants increase risk for T2D are not well-established. We used 13 expression assays to survey mRNA expression of multiple TCF7L2 splicing forms in up to 380 samples from eight types of human tissue (pancreas, pancreatic islets, colon, liver, monocytes, skeletal muscle, subcutaneous adipose tissue and lymphoblastoid cell lines) and observed a tissue-specific pattern of alternative splicing. We tested whether the expression of TCF7L2 splicing forms was associated with single nucleotide polymorphisms (SNPs), rs7903146 and rs12255372, located within introns 3 and 4 of the gene and most strongly associated with T2D. Expression of two splicing forms was lower in pancreatic islets with increasing counts of T2D-associated alleles of the SNPs: a ubiquitous splicing form (P = 0.018 for rs7903146 and P = 0.020 for rs12255372) and a splicing form found in pancreatic islets, pancreas and colon but not in other tissues tested here (P = 0.009 for rs12255372 and P = 0.053 for rs7903146). Expression of this form in glucose-stimulated pancreatic islets correlated with expression of proinsulin (r2 = 0.84–0.90, P < 0.00063). In summary, we identified a tissue-specific pattern of alternative splicing of TCF7L2. After adjustment for multiple tests, no association between expression of TCF7L2 in eight types of human tissue samples and T2D-associated genetic variants remained significant. Alternative splicing of TCF7L2 in pancreatic islets warrants future studies. GenBank Accession Numbers: FJ010164–FJ010174. PMID:19602480

Adaptive Memory: Evaluating Alternative Forms of Fitness-Relevant Processing in the Survival Processing Paradigm

PubMed Central

Sandry, Joshua; Trafimow, David; Marks, Michael J.; Rice, Stephen

2013-01-01

Memory may have evolved to preserve information processed in terms of its fitness-relevance. Based on the assumption that the human mind comprises different fitness-relevant adaptive mechanisms contributing to survival and reproductive success, we compared alternative fitness-relevant processing scenarios with survival processing. Participants rated words for relevancy to fitness-relevant and control conditions followed by a delay and surprise recall test (Experiment 1a). Participants recalled more words processed for their relevance to a survival situation. We replicated these findings in an online study (Experiment 2) and a study using revised fitness-relevant scenarios (Experiment 3). Across all experiments, we did not find a mnemonic benefit for alternative fitness-relevant processing scenarios, questioning assumptions associated with an evolutionary account of remembering. Based on these results, fitness-relevance seems to be too wide-ranging of a construct to account for the memory findings associated with survival processing. We propose that memory may be hierarchically sensitive to fitness-relevant processing instructions. We encourage future researchers to investigate the underlying mechanisms responsible for survival processing effects and work toward developing a taxonomy of adaptive memory. PMID:23585858

Alternative forms of axial startle behaviors in fishes.

PubMed

Liu, Yen-Chyi; Hale, Melina E

2014-02-01

For most aquatic vertebrates, axial movements play key roles in the performance of startle responses. In fishes, these axis-based startle behaviors fall into three distinct categories - the C-start, withdrawal, and S-start - defined by patterns of body bending and underlying motor control. Startle behaviors have been widely studied due to their importance for predator evasion. In addition, the neural circuits that control startles are relatively accessible, compared to other vertebrate circuits, and have provided opportunities to understand basic nervous system function. The C-start neural circuit has long been a model in systems neuroscience and considerable work on neural control of withdrawal response has been conducted in the larval lamprey. The S-start response has only recently been explored from a physiological perspective and we focus here on reviewing S-start motor control and movement in the context of the other two responses. Axial elongation has previously been associated with startle behavior in comparisons of C-starts and withdrawal, with extremely elongate animals performing withdrawals. We suggest that the S-start tends to occur with moderate body elongation, complementing the C-start in animals with this body form. As many larval fishes are moderately elongate, we suggest that the S-start may be common in larvae but may be secondarily lost with body shape change through development. Copyright © 2013 Elsevier GmbH. All rights reserved.

Complementary and Alternative Medicine: A Cross-Sectional Observational Study in Pediatric Inpatients

PubMed Central

Dhankar, Mukesh

2018-01-01

The aim was to study the prevalence of complementary and alternative medicine use in acutely sick hospitalized children and factors associated with it. This is a cross-sectional, hospital-based study in a tertiary care center of Delhi, India. Children admitted to a pediatric unit during the study period were assessed using a specially designed questionnaire. Out of the total 887 admitted children, 161 (18.1%) were using complementary and alternate medicine in one form or another. Of these, 113 (70.2%) were using complementary and alternate medicine for the current illness directly leading to admission and the remaining 48 (29.8%) had used complementary and alternate medicine in past. The common complementary and alternate medicine use observed in our study was combined ayurveda and spiritual approach (25.5%), ayurveda (24.8%), spiritual (21.7%), homeopathic (13%), and 47.2% of children were using spiritual approach in form of Jhada (tying piece of cloth on arm or leg or keeping a knife by the side of child). The significant factors associated with complementary and alternate medicine use were younger age, female gender, and father being employed. Complementary and alternate medicine is commonly used even in acutely sick children. PMID:29616560

19 CFR 4.7a - Inward manifest; information required; alternative forms.

Code of Federal Regulations, 2013 CFR

2013-04-01

... comprising the inward manifest shall be completed as follows: (a) Ship's Stores Declaration. Articles to be retained aboard as sea or ship's stores shall be listed on the Ship's Stores Declaration, CBP Form 1303. Less than whole packages of sea or ship's stores may be described as “sundry small and broken stores...

19 CFR 4.7a - Inward manifest; information required; alternative forms.

Code of Federal Regulations, 2014 CFR

2014-04-01

... comprising the inward manifest shall be completed as follows: (a) Ship's Stores Declaration. Articles to be retained aboard as sea or ship's stores shall be listed on the Ship's Stores Declaration, CBP Form 1303. Less than whole packages of sea or ship's stores may be described as “sundry small and broken stores...

19 CFR 4.7a - Inward manifest; information required; alternative forms.

Code of Federal Regulations, 2012 CFR

2012-04-01

... comprising the inward manifest shall be completed as follows: (a) Ship's Stores Declaration. Articles to be retained aboard as sea or ship's stores shall be listed on the Ship's Stores Declaration, CBP Form 1303. Less than whole packages of sea or ship's stores may be described as “sundry small and broken stores...

19 CFR 4.7a - Inward manifest; information required; alternative forms.

Code of Federal Regulations, 2011 CFR

2011-04-01

... comprising the inward manifest shall be completed as follows: (a) Ship's Stores Declaration. Articles to be retained aboard as sea or ship's stores shall be listed on the Ship's Stores Declaration, Customs Form 1303. Less than whole packages of sea or ship's stores may be described as “sundry small and broken stores...

Schizophyllum commune has an extensive and functional alternative splicing repertoire

PubMed Central

Gehrmann, Thies; Pelkmans, Jordi F.; Lugones, Luis G.; Wösten, Han A. B.; Abeel, Thomas; Reinders, Marcel J. T.

2016-01-01

Recent genome-wide studies have demonstrated that fungi possess the machinery to alternatively splice pre-mRNA. However, there has not been a systematic categorization of the functional impact of alternative splicing in a fungus. We investigate alternative splicing and its functional consequences in the model mushroom forming fungus Schizophyllum commune. Alternative splicing was demonstrated for 2,285 out of 12,988 expressed genes, resulting in 20% additional transcripts. Intron retentions were the most common alternative splicing events, accounting for 33% of all splicing events, and 43% of the events in coding regions. On the other hand, exon skipping events were rare in coding regions (1%) but enriched in UTRs where they accounted for 57% of the events. Specific functional groups, including transcription factors, contained alternatively spliced genes. Alternatively spliced transcripts were regulated differently throughout development in 19% of the 2,285 alternatively spliced genes. Notably, 69% of alternatively spliced genes have predicted alternative functionality by loss or gain of functional domains, or by acquiring alternative subcellular locations. S. commune exhibits more alternative splicing than any other studied fungus. Taken together, alternative splicing increases the complexity of the S. commune proteome considerably and provides it with a rich repertoire of alternative functionality that is exploited dynamically. PMID:27659065

Schizophyllum commune has an extensive and functional alternative splicing repertoire

DOE PAGES

Gehrmann, Thies; Pelkmans, Jordi F.; Lugones, Luis G.; ...

2016-09-23

Recent genome-wide studies have demonstrated that fungi possess the machinery to alternatively splice pre-mRNA. However, there has not been a systematic categorization of the functional impact of alternative splicing in a fungus. We investigate alternative splicing and its functional consequences in the model mushroom forming fungus Schizophyllum commune. Alternative splicing was demonstrated for 2,285 out of 12,988 expressed genes, resulting in 20% additional transcripts. Intron retentions were the most common alternative splicing events, accounting for 33% of all splicing events, and 43% of the events in coding regions. On the other hand, exon skipping events were rare in coding regionsmore » (1%) but enriched in UTRs where they accounted for 57% of the events. Specific functional groups, including transcription factors, contained alternatively spliced genes. Alternatively spliced transcripts were regulated differently throughout development in 19% of the 2,285 alternatively spliced genes. Notably, 69% of alternatively spliced genes have predicted alternative functionality by loss or gain of functional domains, or by acquiring alternative subcellular locations. S. commune exhibits more alternative splicing than any other studied fungus. Finally, taken together, alternative splicing increases the complexity of the S. commune proteome considerably and provides it with a rich repertoire of alternative functionality that is exploited dynamically.« less

Nitrate removal from pharmaceutical wastewater using microbial electrochemical system supplied through low frequency-low voltage alternating electric current.

PubMed

Hoseinzadeh, Edris; Rezaee, Abbas; Farzadkia, Mahdi

2018-04-01

In this study, a microbial electrochemical system (MES) was designed to evaluate the effects of a low frequency-low voltage alternating electrical current on denitrification efficacy in the presence of ibuprofen as a low biodegradable organic carbon source. Cylindrical carbon cloth and stainless steel mesh electrodes containing a consortium of heterotrophic and autotrophic bacteria were mounted in the wall of the designed laboratory-scale bioreactor. The effects of inlet nitrate concentration (50-800mgL -1 ), retention time (2.5-24h), waveform magnitude (0.1-9.6V p-p ), adjustable direct current voltage added to offset voltage (0.1-4.9V), alternating current frequency (10-60Hz), and waveforms (sinusoidal, square, and ramp) were studied in this work. The results showed that the proposed system removes 800mgL -1 nitrate up to 95% during 6.5h. Optimum conditions were obtained in the 8V p-p using a frequency of 10Hz of a sinusoidal waveform. The morphology studies confirmed bacterial morphology change when applying the alternating current. Dehydrogenase activity of biofilms formed on surface of stainless steel electrodes increased to 15.24μgTFmg biomass cm -2 d. The maximum bacterial activity was obtained at a voltage of 8V p-p . The experimental results revealed that the MES using a low frequency-low voltage alternating electrical current is a promising technique for nitrate removal from pharmaceutical wastewaters in the presence of low biodegradability of carbon sources such as ibuprofen. Copyright © 2017 Elsevier B.V. All rights reserved.

Simultaneous Quantification of Multiple Alternatively Spliced mRNA Transcripts Using Droplet Digital PCR.

PubMed

Sun, Bing; Zheng, Yun-Ling

2018-01-01

Currently there is no sensitive, precise, and reproducible method to quantitate alternative splicing of mRNA transcripts. Droplet digital™ PCR (ddPCR™) analysis allows for accurate digital counting for quantification of gene expression. Human telomerase reverse transcriptase (hTERT) is one of the essential components required for telomerase activity and for the maintenance of telomeres. Several alternatively spliced forms of hTERT mRNA in human primary and tumor cells have been reported in the literature. Using one pair of primers and two probes for hTERT, four alternatively spliced forms of hTERT (α-/β+, α+/β- single deletions, α-/β- double deletion, and nondeletion α+/β+) were accurately quantified through a novel analysis method via data collected from a single ddPCR reaction. In this chapter, we describe this ddPCR method that enables direct quantitative comparison of four alternatively spliced forms of the hTERT messenger RNA without the need for internal standards or multiple pairs of primers specific for each variant, eliminating the technical variation due to differential PCR amplification efficiency for different amplicons and the challenges of quantification using standard curves. This simple and straightforward method should have general utility for quantifying alternatively spliced gene transcripts.

Brewer’s spent grain and corn steep liquor as alternative culture medium substrates for proteinase production by Streptomyces malaysiensis AMT-3

PubMed Central

do Nascimento, Rodrigo Pires; Junior, Nelson Alves; Coelho, Rosalie Reed Rodrigues

2011-01-01

Brewer’s spent grain and corn steep liquor or yeast extract were used as the sole organic forms for proteinase production by Streptomyces malaysiensis in submerged fermentation. The influence of the C and N concentrations, as well as the incubation periods, were assessed. Eight proteolytic bands were detected through gelatin-gel-electrophoresis in the various extracts obtained from the different media and after different incubation periods, with apparent molecular masses of 20, 35, 43, 50, 70, 100, 116 and 212 kDa. The results obtained suggest an opportunity for exploring this alternative strategy for proteinases production by actinomycetes, using BSG and CSL as economically feasible substrates. PMID:24031767

Improved method for in vitro secondary amastigogenesis of Trypanosoma cruzi: morphometrical and molecular analysis of intermediate developmental forms.

PubMed

Hernández-Osorio, L A; Márquez-Dueñas, C; Florencio-Martínez, L E; Ballesteros-Rodea, G; Martínez-Calvillo, S; Manning-Cela, R G

2010-01-01

Trypanosoma cruzi undergoes a biphasic life cycle that consists of four alternate developmental stages. In vitro conditions to obtain a synchronic transformation and efficient rates of pure intermediate forms (IFs), which are indispensable for further biochemical, biological, and molecular studies, have not been reported. In the present study, we established an improved method to obtain IFs from secondary amastigogenesis. During the transformation kinetics, we observed progressive decreases in the size of the parasite body, undulating membrane and flagellum that were concomitant with nucleus remodeling and kinetoplast displacement. In addition, a gradual reduction in parasite movement and acquisition of the amastigote-specific Ssp4 antigen were observed. Therefore, our results showed that the in vitro conditions used obtained large quantities of highly synchronous and pure IFs that were clearly distinguished by morphometrical and molecular analyses. Obtaining these IFs represents the first step towards an understanding of the molecular mechanisms involved in amastigogenesis.

Alternative Fuels Data Center: Alternative Fueling Station Locator

Science.gov Websites

Locate Stations Printable Version Share this resource Send a link to Alternative Fuels Data Center : Alternative Fueling Station Locator to someone by E-mail Share Alternative Fuels Data Center: Alternative Fuels Data Center: Alternative Fueling Station Locator on Digg Find More places to share Alternative

Alternative approximation concepts for space frame synthesis

NASA Technical Reports Server (NTRS)

Lust, R. V.; Schmit, L. A.

1985-01-01

A structural synthesis methodology for the minimum mass design of 3-dimensionall frame-truss structures under multiple static loading conditions and subject to limits on displacements, rotations, stresses, local buckling, and element cross-sectional dimensions is presented. A variety of approximation concept options are employed to yield near optimum designs after no more than 10 structural analyses. Available options include: (A) formulation of the nonlinear mathematcal programming problem in either reciprocal section property (RSP) or cross-sectional dimension (CSD) space; (B) two alternative approximate problem structures in each design space; and (C) three distinct assumptions about element end-force variations. Fixed element, design element linking, and temporary constraint deletion features are also included. The solution of each approximate problem, in either its primal or dual form, is obtained using CONMIN, a feasible directions program. The frame-truss synthesis methodology is implemented in the COMPASS computer program and is used to solve a variety of problems. These problems were chosen so that, in addition to exercising the various approximation concepts options, the results could be compared with previously published work.

Responses to Anomalous Data Obtained from Repeatable Experiments in the Laboratory

ERIC Educational Resources Information Center

Lin, Jer-Yann

2007-01-01

The purpose of this study was to investigate the possible responses to anomalous data obtained from experiments that are repeatable by carrying out additional or alternative experiments in the laboratory. Based on an analysis of responses from scientists to anomalous data taken from identification experiments on the Vinland Map, it was assumed…

Disaggregate demand for conventional and alternative fuelled vehicles in the Census Metropolitan Area of Hamilton, Canada

NASA Astrophysics Data System (ADS)

Potoglou, Dimitrios

The focus of this thesis is twofold. First, it offers insight on how households' car-ownership behaviour is affected by urban form and availability of local-transit at the place of residence, after controlling for socio-economic and demographic characteristics. Second, it addresses the importance of vehicle attributes, household and individual characteristics as well as economic incentives and urban form to potential demand for alternative fuelled vehicles. Data for the empirical analyses of the aforementioned research activities were obtained through an innovative Internet survey, which is also documented in this thesis, conducted in the Census Metropolitan Area of Hamilton. The survey included a retrospective questionnaire of households' number and type of vehicles and a stated choices experiment for assessing the potential demand for alternative fuelled vehicles. Established approaches and emerging trends in automobile demand modelling identified early on in this thesis suggest a disaggregate approach and specifically, the estimation of discrete choice models both for explaining car ownership and vehicle-type choice behaviour. It is shown that mixed and diverse land uses as well as short distances between home and work are likely to decrease the probability of households to own a large number of cars. Regarding the demand for alternative fuelled vehicles, while vehicle attributes are particularly important, incentives such as free parking and access to high occupancy vehicle lanes will not influence the choice of hybrids or alternative fuelled vehicles. An improved understating of households' behaviour regarding the number of cars as well as the factors and trade-offs for choosing cleaner vehicles can be used to inform policy designed to reduce car ownership levels and encourage adoption of cleaner vehicle technologies in urban areas. Finally, the Internet survey sets the ground for further research on implementation and evaluation of this data collection method.

Alternating-script priming in Japanese: Are Katakana and Hiragana characters interchangeable?

PubMed

Perea, Manuel; Nakayama, Mariko; Lupker, Stephen J

2017-07-01

Models of written word recognition in languages using the Roman alphabet assume that a word's visual form is quickly mapped onto abstract units. This proposal is consistent with the finding that masked priming effects are of similar magnitude from lowercase, uppercase, and alternating-case primes (e.g., beard-BEARD, BEARD-BEARD, and BeArD-BEARD). We examined whether this claim can be readily generalized to the 2 syllabaries of Japanese Kana (Hiragana and Katakana). The specific rationale was that if the visual form of Kana words is lost early in the lexical access process, alternating-script repetition primes should be as effective as same-script repetition primes at activating a target word. Results showed that alternating-script repetition primes were less effective at activating lexical representations of Katakana words than same-script repetition primes-indeed, they were no more effective than partial primes that contained only the Katakana characters from the alternating-script primes. Thus, the idiosyncrasies of each writing system do appear to shape the pathways to lexical access. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Characterizing AISI 1045 steel surface duplex-treated by alternating current field enhanced pack aluminizing and nitriding

NASA Astrophysics Data System (ADS)

Xie, Fei; Zhang, Ge; Pan, Jianwei

2018-02-01

Thin cases and long treating time are shortcomings of conventional duplex treatment of aluminizing followed by nitriding (DTAN). Alternating current field (ACF) enhanced DTAN was carried out on AISI 1045 steel by applying an ACF to treated samples and treating agents with a pair of electrodes for overcoming those shortcomings. By investigating cases' structures, phases, composition and hardness distributions of differently treated samples, preliminary studies were made on characterizations of the ACF enhanced duplex treatment to AISI 1045 steel. The results show that, with the help of the ACF, the surface Al-rich phase Al5Fe2 formed in conventional pack aluminizing can be easily avoided and the aluminizing process is dramatically promoted. The aluminizing case can be nitrided either with conventional pack nitriding or ACF enhanced pack nitriding. By applying ACF to pack nitriding, the diffusion of nitrogen into the aluminizing case is promoted. AlN, Fe2∼3N and solid solution of N in iron are efficiently formed as a result of reactions of N with the aluminizing case. A duplex treated case with an effective thickness of more than 170 μm can be obtained by the alternating current field enhanced 4 h pack aluminizing plus 4 h pack nitriding.

Structuration of lipid bases with fully hydrogenated crambe oil and sorbitan monostearate for obtaining zero-trans/low sat fats.

PubMed

Stahl, Marcella Aparecida; Buscato, Monise Helen Masuchi; Grimaldi, Renato; Cardoso, Lisandro Pavie; Ribeiro, Ana Paula Badan

2018-05-01

Several studies have shown that excessive intake of trans and saturated fatty acids is associated with an increased risk of cardiovascular disease. In this context, the food industry has sought alternatives for the development of healthy lipid bases, with higher levels of unsaturated fatty acids, adapting to current legislation. The incorporation of structuring agents into liquid oils has proven to be a potential alternative for obtaining semi-plastic lipid bases with reduced levels of saturated fatty acids. Thus, the objective of this study was to produce zero trans fat bases with lower saturated fatty acids levels. Palm oil (PO) was used as a zero trans-lipid base reference because of its technological functionality. Blends containing different proportions of high oleic sunflower oil (HOSO) and PO were prepared as follows: control 100: 0; 80:20; 60:40; 40:60; 20:80; and 100: 0 PO: HOSO (w/w%), respectively. Then, 3% of fully hydrogenated crambe oil (FHCO) and 3% sorbitan monostearate (SMS) were added to the blends as structuring agents, forming the structured (S) blends. The addition of HOSO to the PO decreased the saturated fatty acids by up to 30.6%, with consequent increase of unsaturated fatty acids, especially oleic acid. The joint action of the SMS and the FCHO allowed for obtaining structured blends with plastic and spreadability characteristics, as well as modifications throughout the crystallization process of the original blends. Copyright © 2018 Elsevier Ltd. All rights reserved.

Complex alternative splicing of acetylcholinesterase transcripts in Torpedo electric organ; primary structure of the precursor of the glycolipid-anchored dimeric form.

PubMed Central

Sikorav, J L; Duval, N; Anselmet, A; Bon, S; Krejci, E; Legay, C; Osterlund, M; Reimund, B; Massoulié, J

1988-01-01

In this paper, we show the existence of alternative splicing in the 3' region of the coding sequence of Torpedo acetylcholinesterase (AChE). We describe two cDNA structures which both diverge from the previously described coding sequence of the catalytic subunit of asymmetric (A) forms (Schumacher et al., 1986; Sikorav et al., 1987). They both contain a coding sequence followed by a non-coding sequence and a poly(A) stretch. Both of these structures were shown to exist in poly(A)+ RNAs, by S1 mapping experiments. The divergent region encoded by the first sequence corresponds to the precursor of the globular dimeric form (G2a), since it contains the expected C-terminal amino acids, Ala-Cys. These amino acids are followed by a 29 amino acid extension which contains a hydrophobic segment and must be replaced by a glycolipid in the mature protein. Analyses of intact G2a AChE showed that the common domain of the protein contains intersubunit disulphide bonds. The divergent region of the second type of cDNA consists of an adjacent genomic sequence, which is removed as an intron in A and Ga mRNAs, but may encode a distinct, less abundant catalytic subunit. The structures of the cDNA clones indicate that they are derived from minor mRNAs, shorter than the three major transcripts which have been described previously (14.5, 10.5 and 5.5 kb). Oligonucleotide probes specific for the asymmetric and globular terminal regions hybridize with the three major transcripts, indicating that their size is determined by 3'-untranslated regions which are not related to the differential splicing leading to A and Ga forms. Images PMID:3181125

40 CFR 211.206-2 - Alternative test data.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PROGRAMS PRODUCT NOISE LABELING Hearing Protective Devices § 211.206-2 Alternative test data. (a) In lieu of testing according to § 211.206-1, manufacturers may use the latest available test data obtained...

Alternative Forms of Schooling

ERIC Educational Resources Information Center

Doll, Ronald C.

1972-01-01

Author talked informally with young people between the ages of 11 and 19 to find out what they think about schooling and education. Proposes high-level deliberation about the full meaning and conduct of education in the United States. (Author/DR)

Alternative magnetic flux leakage modalities for pipeline inspection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Katragadda, G.; Lord, W.; Sun, Y.S.

1996-05-01

Increasing quality consciousness is placing higher demands on the accuracy and reliability of inspection systems used in defect detection and characterization. Nondestructive testing techniques often rely on using multi-transducer approaches to obtain greater defect sensitivity. This paper investigates the possibility of taking advantage of alternative modalities associated with the standard magnetic flux leakage tool to obtain additional defect information, while still using a single excitation source.

Alternative Fuels Data Center: Test Your Alternative Fuel IQ

Science.gov Websites

Test Your Alternative Fuel IQ to someone by E-mail Share Alternative Fuels Data Center: Test Your Alternative Fuel IQ on Facebook Tweet about Alternative Fuels Data Center: Test Your Alternative Fuel IQ on Twitter Bookmark Alternative Fuels Data Center: Test Your Alternative Fuel IQ on Google Bookmark

Factors influencing preferences for alternative medicine by Korean Americans.

PubMed

Kim, Jeongseon; Chan, Mabel M

2004-01-01

Use of alternative medicine among the public has increased rapidly over the last few decades. Studies on alternative health care have been conducted on the general public and on major ethnic groups, but not on Korean Americans, who are one of the fastest growing Asian populations in the United States. This study was a cross-sectional survey of 143 Korean Americans in the Greater New York Metropolitan area; all of them were users of alternative medicine. Inter-correlations of hypothetical demographic predictors and preferences for alternative medicine were obtained. Multiple logistic regression analyses were used to identify factors influencing alternative medicine preferences. Most of the respondents answered that they preferred alternative medicine because of philosophical congruence, i.e. they found alternative therapies compatible with their values, world views, spiritual/religious philosophies, and beliefs regarding the nature and meaning of health and illness. The results show that younger, well-educated respondents, with significant acculturation level, and have stayed in the US for a relatively short period of time preferred alternative medicine. The information derived from this and similar studies may be of potential value to the biomedical community, governmental agencies, insurance companies and managed care organizations.

Field assessment of alternative bed-load transport estimators

USGS Publications Warehouse

Gaeuman, G.; Jacobson, R.B.

2007-01-01

Measurement of near-bed sediment velocities with acoustic Doppler current profilers (ADCPs) is an emerging approach for quantifying bed-load sediment fluxes in rivers. Previous investigations of the technique have relied on conventional physical bed-load sampling to provide reference transport information with which to validate the ADCP measurements. However, physical samples are subject to substantial errors, especially under field conditions in which surrogate methods are most needed. Comparisons between ADCP bed velocity measurements with bed-load transport rates estimated from bed-form migration rates in the lower Missouri River show a strong correlation between the two surrogate measures over a wide range of mild to moderately intense sediment transporting conditions. The correlation between the ADCP measurements and physical bed-load samples is comparatively poor, suggesting that physical bed-load sampling is ineffective for ground-truthing alternative techniques in large sand-bed rivers. Bed velocities measured in this study became more variable with increasing bed-form wavelength at higher shear stresses. Under these conditions, bed-form dimensions greatly exceed the region of the bed ensonified by the ADCP, and the magnitude of the acoustic measurements depends on instrument location with respect to bed-form crests and troughs. Alternative algorithms for estimating bed-load transport from paired longitudinal profiles of bed topography were evaluated. An algorithm based on the routing of local erosion and deposition volumes that eliminates the need to identify individual bed forms was found to give results similar to those of more conventional dune-tracking methods. This method is particularly useful in cases where complex bed-form morphology makes delineation of individual bed forms difficult. ?? 2007 ASCE.

48 CFR 952.227-14 - Rights in data-general. (DOE coverage-alternates VI and VII)

Code of Federal Regulations, 2012 CFR

2012-10-01

.... (DOE coverage-alternates VI and VII) 952.227-14 Section 952.227-14 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.227-14 Rights in data-general. (DOE coverage—alternates VI and VII) Alternate VI...

48 CFR 952.227-14 - Rights in data-general. (DOE coverage-alternates VI and VII)

Code of Federal Regulations, 2014 CFR

2014-10-01

.... (DOE coverage-alternates VI and VII) 952.227-14 Section 952.227-14 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.227-14 Rights in data-general. (DOE coverage—alternates VI and VII) Alternate VI...

48 CFR 952.227-14 - Rights in data-general. (DOE coverage-alternates VI and VII)

Code of Federal Regulations, 2013 CFR

2013-10-01

.... (DOE coverage-alternates VI and VII) 952.227-14 Section 952.227-14 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.227-14 Rights in data-general. (DOE coverage—alternates VI and VII) Alternate VI...

Application of alternative medicine in gastrointestinal cancer patients.

PubMed

Nikolić, Ivan; Smiljenić, Dragana; Kukić, Biljana; Bogdanović, Bogdan; Petrović, Tomislav; Ivković-Kapicl, Tatjana; Kozarski, Dejan; Djan, Igor

2012-11-01

[corrected] Alternative medicine is a set of therapeutic procedures which are no part of official practice. At present, the use of alternative medicine among cancer patients is significant and the purpose of this study was to get more information on the methods and products of alternative medicine. Thus, the aim of the study was to determine the frequency of the use of alternative medicine among gastrointestinal cancer patients. The research was conducted using an anonymous questionnaire in writing. We included 205 patients with the diagnosis of gastrointestinal malignancy in the study but the questionnaire was fulfilled by 193 patients and the presented data were based on their answers. The questions were about the sociodemographic characteristics of the patients, the reasons for their use of alternative medicine, and their information sources about alternative medicine. We divided existing alternative therapies into 6 categories: herbal therapy, special diets, psychotherapy, body-mind therapy, spiritual therapy, and other supplements. A total of 48 (24.9%) patients did not use any type of alternative therapy; 145 (75.1%) patients used at least one product and 124 (64.25%) patients used herbal preparations (beetroot juice was consumed by 110 [56.99%] patients); 136 (70.5%) patients were informed about alternative therapies by other patients; 145 (75.1%) used alternative medicine to increase the chances for cure; 88 (45.6%) of interviewed patients would like to participate in future research in this field. The use of alternative medicine is evidently significant among cancer patients. Further research should be conducted in order to find out interactions of these products with other drugs and potential advantages and disadvantages of this form of treatment.

On the origin of phosphorus nitride in star-forming regions

NASA Astrophysics Data System (ADS)

Mininni, C.; Fontani, F.; Rivilla, V. M.; Beltrán, M. T.; Caselli, P.; Vasyunin, A.

2018-05-01

We present multitransition observations of phosphorus nitride (PN) towards a sample of nine massive dense cores in different evolutionary stages. Using transitions with different excitation conditions, we have found for the first time that the excitation temperatures of PN are in the range ˜5-30 K. To investigate the main chemical route for the PN formation (surface-chemistry versus gas-phase chemistry), and the dominant desorption mechanism (thermal versus shock), we have compared our results with those obtained from molecules tracing different chemical and physical conditions (SiO, SO, CH3OH, and N2H+). We have found that the PN line profiles are very well correlated with those of SiO and SO in six out of the nine targets, which indicate that PN may be released by sputtering of dust grains due to shocks. This finding is corroborated by a faint but statistically significant positive trend between the PN abundance and those of SiO and SO. However, in three objects the PN lines have no hints of high-velocity wings, which indicates an alternative origin of PN. Overall, our results indicate that the origin of PN is not unique, as it can be formed not only in protostellar shocks, but also in colder and more quiescent gas through alternative pathways.

Approaches for springback reduction when forming ultra high-strength sheet metals

NASA Astrophysics Data System (ADS)

Radonjic, R.; Liewald, M.

2016-11-01

Nowadays, the automotive industry is challenged constantly by increasing environmental regulations and the continuous enhancement of standards with regard to passenger's safety (NCAP, Part 1). In order to fulfil the aforementioned requirements, the use of ultra high-strength steels in research and industrial applications is of high interest. When forming such materials, the main problem results from the large amount of springback which occurs after the release of the part. This paper shows the applicability of several approaches for the reduction of springback amount by forming of one hat channel shaped component. A novel approach for springack reduction which is based on forming with an alternating blank draw-in is presented as well. In this investigation an ultra high-strength steel of the grade DP 980 was used. The part's measurements were taken at significant cross-sections in order to provide a qualitative comparison between the reference geometry and the part's released shape. The obtained results were analysed and used in order to quantify the success of particular approaches for springback reduction. When taking a curved hat channel shaped component as an example, the results achieved in the investigations showed that it is possible to reduce part shape deviations significantly when using DP 980 as workpiece material.

Bioavailability of intranasal promethazine dosage forms in dogs

NASA Technical Reports Server (NTRS)

Ramanathan, R.; Geary, R. S.; Bourne, D. W.; Putcha, L.

1998-01-01

Intramuscular promethazine (PMZ) is used aboard the US Space Shuttle to ameliorate symptoms of space motion sickness. Bioavailability after an oral dose of PMZ during space flight is thought to be impaired because of gastrointestinal disturbances associated with weightlessness and space motion sickness. In an attempt to find an alternative dosage form for use in space, we evaluated two intranasal (i.n.) dosage forms of PMZ in dogs for absorption and bioavailability relative to that of an equivalent intramuscular dose. Promethazine (5 mg kg-1) was administered as two intranasal dosage forms and as an intramuscular (i.m.) dose to three dogs in a randomised cross-over design. Serial blood samples were taken and analysed for PMZ concentrations and the absorption and bioavailability of PMZ were calculated for the three dosage forms. PMZ absorption from the carboxymethyl cellulose microsphere i.n. dosage form was more rapid and complete than from the myverol cubic gel formulation or from an i.m. injection. Bioavailability of the microsphere formulation was also greater than that of the gel formulation (AUC 3009 vs 1727 ng h ml-1). The bioavailability of the two i.n. dosage forms (relative to that of the i.m. injection) were 94% (microsphere) and 54% (gel). The i.n. microsphere formulation of PMZ offers great promise as an effective non-invasive alternative for treating space motion sickness due to its rapid absorption and bioavailability equivalent to the i.m. dose.

Alternative security

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weston, B.H.

This book contains the following chapters: The Military and Alternative Security: New Missions for Stable Conventional Security; Technology and Alternative Security: A Cherished Myth Expires; Law and Alternative Security: Toward a Just World Peace; Politics and Alternative Security: Toward a More Democratic, Therefore More Peaceful, World; Economics and Alternative Security: Toward a Peacekeeping International Economy; Psychology and Alternative Security: Needs, Perceptions, and Misperceptions; Religion and Alternative Security: A Prophetic Vision; and Toward Post-Nuclear Global Security: An Overview.

The Bach equations in spin-coefficient form

NASA Astrophysics Data System (ADS)

Forbes, Hamish

2018-06-01

Conformal gravity theories are defined by field equations that determine only the conformal structure of the spacetime manifold. The Bach equations represent an early example of such a theory, we present them here in component form in terms of spin- and boost-weighted spin-coefficients using the compacted spin-coefficient formalism. These equations can be used as an efficient alternative to the standard tensor form. As a simple application we solve the Bach equations for pp-wave and static spherically symmetric spacetimes.

Alternative Work Experience Programs. Final Report.

ERIC Educational Resources Information Center

Karnes, M. Ray

A study was conducted in six south central Mississippi counties (1) to determine the incidence of part-time employment of in-school youth by age, grade, sex, and race; (2) to determine types of part-time jobs held by youths while in public school and their available work experience alternatives; (3) to obtain employed youth and their parents'…

Alternatives to amputation.

PubMed Central

Lendrum, J.

1980-01-01

Alternatives to conventional skin flap cover for limb wounds extend both the number and type of defects which can now be closed with reconstruction of both form and function for patients who might otherwise come to amputation. The old adage that where a sinus leads to dead or foreign material it can only be closed after removal of that dead or foreign material is no longer true. The number of patients coming to above-knee amputation after prosthetic replacement of the knee joint could be reduced by muscle flap cover of exposed arthroplasty prostheses. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 PMID:7377695

Alternative Conceptions: Turning Adversity into Advantage

NASA Astrophysics Data System (ADS)

Ferreira, Annalize; Lemmer, Miriam; Gunstone, Richard

2017-08-01

While a vast body of research has identified difficulties in students' understanding about forces and acceleration and their related alternative conceptions, far less research suggests ways to use students' alternative conceptions to enhance conceptual understanding of a specific fundamental concept. This study focused on distinguishing between students' conceptual understanding of the Newtonian concept of gravitational acceleration being the same for all objects and students' alternative conception that heavy objects fall faster. A multiple choice questionnaire was distributed to first year physics students for three consecutive years at a university in South Africa. The results indicate that changing the direction of motion and the physics quantity asked in paired questions revealed practically significant inconsistencies in students' reasoning and conceptions. This research contributes to the body of knowledge in proposing how the alternative conception of mass-related gravitational acceleration can be used in instruction to enhance conceptual understanding of the force-mass-acceleration relationship. Understanding of this relationship not only promotes conceptual understanding of the basic Newtonian concepts of the laws of motion which forms the critical foundation on which more advanced physics courses are built, but also contributes towards students' perception of physics as a set of coherent ideas applicable in all contexts.

Comparison of Alternate and Original Items on the Montreal Cognitive Assessment.

PubMed

Lebedeva, Elena; Huang, Mei; Koski, Lisa

2016-03-01

The Montreal Cognitive Assessment (MoCA) is a screening tool for mild cognitive impairment (MCI) in elderly individuals. We hypothesized that measurement error when using the new alternate MoCA versions to monitor change over time could be related to the use of items that are not of comparable difficulty to their corresponding originals of similar content. The objective of this study was to compare the difficulty of the alternate MoCA items to the original ones. Five selected items from alternate versions of the MoCA were included with items from the original MoCA administered adaptively to geriatric outpatients (N = 78). Rasch analysis was used to estimate the difficulty level of the items. None of the five items from the alternate versions matched the difficulty level of their corresponding original items. This study demonstrates the potential benefits of a Rasch analysis-based approach for selecting items during the process of development of parallel forms. The results suggest that better match of the items from different MoCA forms by their difficulty would result in higher sensitivity to changes in cognitive function over time.

Comparison of Alternate and Original Items on the Montreal Cognitive Assessment

PubMed Central

Lebedeva, Elena; Huang, Mei; Koski, Lisa

2016-01-01

Background The Montreal Cognitive Assessment (MoCA) is a screening tool for mild cognitive impairment (MCI) in elderly individuals. We hypothesized that measurement error when using the new alternate MoCA versions to monitor change over time could be related to the use of items that are not of comparable difficulty to their corresponding originals of similar content. The objective of this study was to compare the difficulty of the alternate MoCA items to the original ones. Methods Five selected items from alternate versions of the MoCA were included with items from the original MoCA administered adaptively to geriatric outpatients (N = 78). Rasch analysis was used to estimate the difficulty level of the items. Results None of the five items from the alternate versions matched the difficulty level of their corresponding original items. Conclusions This study demonstrates the potential benefits of a Rasch analysis-based approach for selecting items during the process of development of parallel forms. The results suggest that better match of the items from different MoCA forms by their difficulty would result in higher sensitivity to changes in cognitive function over time. PMID:27076861

Comparison of accuracy and completeness of data obtained from three types of automatic water-quality monitors

USGS Publications Warehouse

Katzenbach, Max

1990-01-01

A comparison of data (specific conductance, dissolved-oxygen concentration, temperature, and pH) collected by the U.S. Geological Survey flowthrough monitor, the U.S. Geological Survey minimonitor, and a self-contained commercial 'packaged-sensor' system indicates that the data obtained by means of the most complete of the three systems. The U.S. Geological Survey flowthrough monitor is powered by 120-volt alternating current and in a heated weather-proof shelter. A pumping system brings water from the stream to sensors clustered in a sample clustered in a sample chamber located in the shelter. This instrument measures output from the senors; data are recorded in binary-coded decimal form on a 16-channel punched-paper tape recorder tape recorder housed in the shelter. The U.S. Geological Survey's minimonitor is powered by an external battery and is housed in a weatherproof shelter. This instrument measures output of instream sensors with extension cables having underwater connectors; data are recorded in binary-coded decimal form on a 16-channel punched-paper tape recorder housed in the shelter. The packaged-sensor system also measures output of senors housed in a packages that is submerged in the stream. It has internal power supply, no moving parts, and does not requires a weatherproof shelter; data are stored are stored in solid-state memory. Minimonitors were installed at four sites in Ohio where U.S. Geological survey flowthrough were in operation. Two package-sensor systems also were assigned to each site and were alternated every two weeks. Detailed records were kept of (1) field measurements, for comparison with monitor-system data from each instrument, and (2) equipment problems that resulted in loss of data. Results of the comparisons shows that the flow-through monitor gave the most accurate and the most complete data.

On the Concept of "Respiration": Biology Student Teachers' Cognitive Structures and Alternative Conceptions

ERIC Educational Resources Information Center

Kurt, Hakan; Ekici, Gulay; Aktas, Murat; Aksu, Ozlem

2013-01-01

In researches, the subject of respiration has been determined to be among subjects about whom participants from all educational levels struggle to form their cognitive structures and have many alternative conceptions. This research was carried out in order to determine biology student teachers' cognitive structures and alternative conceptions…

Alternative Fuels Data Center: Johnson Space Center Explores Alternative

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Fuel Vehicles Johnson Space Center Explores Alternative Fuel Vehicles to someone by E-mail Share Alternative Fuels Data Center: Johnson Space Center Explores Alternative Fuel Vehicles on Facebook Tweet about Alternative Fuels Data Center: Johnson Space Center Explores Alternative Fuel Vehicles on

Relationship Domain of Form Six Teachers Thinking in Teaching with External Factors of Form Six Teachers

ERIC Educational Resources Information Center

bin Pet, Mokhtar; Sihes, Ahmad Johari Hj

2015-01-01

This study aims to examine the external factors of form six teachers who can influence thinking domain form six teachers in their teaching. This study was conducted using a quantitative approach using questionnaires. A total of 300 form six teacher schools in Johor were chosen as respondents. The findings were obtained as student background…

Substantially isotactic, linear, alternating copolymers of carbon monoxide and an olefin

DOEpatents

Sen, Ayusman; Jiang, Zhaozhong

1996-01-01

The compound, [Pd(Me-DUPHOS)(MeCN).sub.2 ](BF.sub.4).sub.2, [Me-DUPHOS: 1,2-bis(2,5-dimethylphospholano)benzene] is an effective catalyst for the highly enantioselective, alternating copolymerization of olefins, such as aliphatic .alpha.-olefins, with carbon monoxide to form optically active, isotactic polymers which can serve as excellent starting materials for the synthesis of other classes of chiral polymers. For example, the complete reduction of a propylene-carbon monoxide copolymer resulted in the formation of a novel, optically active poly(1,4-alcohol). Also, the previously described catalyst is a catalyst for the novel alternating isomerization cooligomerization of 2-butene with carbon monoxide to form optically active, isotactic poly(1,5-ketone)

Substantially isotactic, linear, alternating copolymers of carbon monoxide and an olefin

DOEpatents

Sen, A.; Jiang, Z.

1996-05-28

The compound, [Pd(Me-DUPHOS)(MeCN){sub 2}](BF{sub 4}){sub 2}, [Me-DUPHOS: 1,2-bis(2,5-dimethylphospholano)benzene] is an effective catalyst for the highly enantioselective, alternating copolymerization of olefins, such as aliphatic {alpha}-olefins, with carbon monoxide to form optically active, isotactic polymers which can serve as excellent starting materials for the synthesis of other classes of chiral polymers. For example, the complete reduction of a propylene-carbon monoxide copolymer resulted in the formation of a novel, optically active poly(1,4-alcohol). Also, the previously described catalyst is a catalyst for the novel alternating isomerization cooligomerization of 2-butene with carbon monoxide to form optically active, isotactic poly(1,5-ketone).

Investigation into the Fiber Orientation Effect on the Formability of GLARE Materials in the Stamp Forming Process

NASA Astrophysics Data System (ADS)

Liu, Shichen; Lang, Lihui; Sherkatghanad, Ehsan; Wang, Yao; Xu, Wencai

2018-04-01

Glass-reinforced aluminum laminate (GLARE) is a new class of fiber metal laminates (FMLs) which has the advantages such as high tensile strength, outstanding fatigue, impact resistance, and excellent corrosion properties. GLARE has been extensively applied in advanced aerospace and automobile industries. However, the deformation behavior of the glass fiber during forming must be studied to the benefits of the good-quality part we form. In this research, we focus on the effect of fiber layer orientation on the GLARE laminate formability in stamp forming process. Experimental and numerical analysis of stamping a hemisphere part in different fiber orientation is investigated. The results indicate that unidirectional and multi-directional fiber in the middle layer make a significant effect on the thinning and also surface forming quality of the three layer sheet. Furthermore, the stress-strain distribution of the aluminum alloy and the unique anisotropic property of the fiber layer exhibit that fiber layer orientation can also affect the forming depths as well as the fracture modes of the laminate. According to the obtained results, it is revealed that multi-directional fiber layers are a good alternative compared to the unidirectional fibers especially when a better formability is the purpose.

Alternative RNA splicing and gastric cancer.

PubMed

Li, Ying; Yuan, Yuan

2017-07-01

Alternative splicing (AS) linked to diseases, especially to tumors. Recently, more and more studies focused on the relationship between AS and gastric cancer (GC). This review surveyed the hot topic from four aspects: First, the common types of AS in cancer, including exon skipping, intron retention, mutually exclusive exon, alternative 5 ' or 3' splice site, alternative first or last exon and alternative 3' untranslated regions. Second, basic mechanisms of AS and its relationship with cancer. RNA splicing in eukaryotes follows the GT-AG rule by both cis-elements and trans-acting factors regulatory. Through RNA splicing, different proteins with different forms and functions can be produced and may be associated with carcinogenesis. Third, AS types of GC-related genes and their splicing variants. In this paper, we listed 10 common genes with AS and illustrated its possible molecular mechanisms owing to genetic variation (mutation and /or polymorphism). Fourth, the splicing variants of GC-associated genes and gastric carcinogenesis, invasion and metastasis. Many studies have found that the different splicing variants of the same gene are differentially expressed in GC and its precancerous diseases, suggesting AS has important implications in GC development. Taking together, this review highlighted the role of AS and splicing variants in the process of GC. We hope that this is not only beneficial to advances in the study field of GC, but also can provide valuable information to other similar tumor research.Although we already know some gene splicing and splicing variants play an important role in the development of GC, but many phenomena and mechanisms are still unknown. For example, how the tumor microenvironment and signal transduction pathway effect the forming and function of AS? Unfortunately, this review did not cover the contents because the current study is limited. It is no doubt that clarifying the phenomena and mechanisms of these unknown may help to reveal

Alternative Fuels Data Center: Alternative Fuels Save Money in Indy

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Alternative Fuels Data Center: Blue Ridge Parkway Incorporates Alternative

Science.gov Websites

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Alternative Fuels Data Center: Alaska Transportation Data for Alternative

Science.gov Websites

Fuels and Vehicles Alaska Transportation Data for Alternative Fuels and Vehicles to someone by E-mail Share Alternative Fuels Data Center: Alaska Transportation Data for Alternative Fuels and Vehicles on Facebook Tweet about Alternative Fuels Data Center: Alaska Transportation Data for Alternative

Final report on cermet high-level waste forms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kobisk, E.H.; Quinby, T.C.; Aaron, W.S.

1981-08-01

Cermets are being developed as an alternate method for the fixation of defense and commercial high level radioactive waste in a terminal disposal form. Following initial feasibility assessments of this waste form, consisting of ceramic particles dispersed in an iron-nickel base alloy, significantly improved processing methods were developed. The characterization of cermets has continued through property determinations on samples prepared by various methods from a variety of simulated and actual high-level wastes. This report describes the status of development of the cermet waste form as it has evolved since 1977. 6 tables, 18 figures.

Medical tourism in the backcountry: alternative health and healing in the Arkansas Ozarks.

PubMed

Nolan, Justin M; Schneider, Mary Jo

2011-01-01

Tourists travel to Arkansas' mountain regions to experience, appreciate, and consume multiple aspects of otherness, including sacred sites and pristine and authentic peoples and environments. A largely unexplored aspect of this consumption of authenticity is alternative medicine, provided to tourists and day travelers in search of physical and emotional restoration. Traditional forms of medicine are deeply rooted in women's social roles as community healers in the region and are perpetuated in part because of the lack of readily accessible forms of so-called modern medicine. Contemporary medical tourism in Arkansas has promoted access to folk health systems, preserving them by incorporating them into tourists' health care services, and also has attracted new and dynamic alternative medical practices while encouraging the transformation of existing forms of traditional medicine. Ultimately, the blend of alternative, folk, and conventional medicine in the Arkansas highlands is evidence of globalizing forces at work in a regional culture. It also serves to highlight a renewed appreciation for the historic continuity and the efficacy of traditional knowledge in the upper South.

Adminsitrator Perception of Management Skills Comparing Traditionally and Alternatively Certified Teachers

ERIC Educational Resources Information Center

Ring, Candi Lynn

2016-01-01

Within the scientific literature there has been no examination of teacher preparation regarding classroom and behavior management skills comparing educators who obtained traditional teacher certification through a university-based education program and those who obtained alternative certification. Consequently, the goal of this study was to assess…

Are patients who use alternative medicine dissatisfied with orthodox medicine?

PubMed

Donnelly, W J; Spykerboer, J E; Thong, Y H

1985-05-13

Approximately 45% of asthmatic families and 47% of non-asthmatic families had consulted an alternative-medicine practitioner at some time. The most popular form of alternative medicine was chiropractic (21.1% and 26.4%, respectively), followed by homoeopathy/naturopathy (18.8% and 12.7%, respectively), acupuncture (9.4% and 10.9%, respectively), and herbal medicine (4.7% and 6.4%, respectively), while the remainder (20.3% and 11.8% respectively) was distributed among iridology, osteopathy, hypnosis, faith healing and megavitamin therapy. More families were satisfied with orthodox medicine (87.1% and 93.6%, respectively) than with alternative medicine (84.2% and 75.1%, respectively). Crosstabulation analysis of pooled data both from asthma and from non-asthma groups showed that 76.4% were satisfied both with orthodox and with alternative medicine, and 16.4% were satisfied with orthodox, but not with alternative, medicine. In contrast, only 2.7% were dissatisfied with orthodox medicine and satisfied with alternative medicine (chi2 = 9.33; P less than 0.01). These findings do not support the view that patients who use alternative medicine are those who are disgruntled with orthodox medicine.

Finite element modelling of chain-die forming for ultra-high strength steel

NASA Astrophysics Data System (ADS)

Majji, Raju; Xiang, Yang; Ding, Scott; Yang, Chunhui

2017-10-01

There has been a high demand for weight reduction in automotive vehicles while maintaining passenger safety. A potential steel material to achieve this is Ultra High Strength Steel (UHSS). As a high strength material, it is difficult to be formed with desired profiles using traditional sheet metal forming processes such as Cold Roll Forming. To overcome this problem, a potentially alternative solution is Chain-die Forming (CDF), recently developed. The basic principal of the CDF is to fully combine roll forming and bending processes. The main advantage of this process is the elongated deformation length that significantly increases effective roll radius. This study focuses on identifying issues with the CDF by using CAD modelling, Motion Analysis and Finite Element Analysis (FEA) to devise solutions and construct a more reliable process in an optimal design sense. Some attempts on finite element modelling and simulation of the CDF were conducted using relatively simple models in literature and the research was still not sufficient enough for optimal design of a typical CDF for UHSS. Therefore two numerical models of Chain-die Forming process are developed in this study, including a) one having a set of rolls similar to roll forming but with a large radius, i.e., 20 meters; and b) the other one with dies and punch segments similar to a typical CDF machine. As a case study, to form a 60° channel with single pass was conducted using these two devised models for a comparison. The obtained numerical results clearly show the CDF could generate less residual stress, low strain and small springback of a single pass for the 60° UHSS channel. The design analysis procedure proposed in this study could greatly help the mechanical designers to devise a cost-effective and reliable CDF process for forming UHSS.

Brayton heat exchanger unit development program (alternate design)

NASA Technical Reports Server (NTRS)

Duncan, J. D.; Gibson, J. C.; Graves, R. F.; Morse, C. J.; Richard, C. E.

1973-01-01

A Brayton Heat Exchanger Unit Alternate Design (BHXU-Alternate) consisting of a recuperator, a heat sink heat exchanger, and a gas ducting system, was designed and fabricated. The design was formulated to provide a high performance unit suitable for use in a long-life Brayton-cycle powerplant. Emphasis was on double containment against external leakage and leakage of the organic coolant into the gas stream. A parametric analysis and design study was performed to establish the optimum component configurations to achieve low weight and size and high reliability, while meeting the requirements of high effectiveness and low pressure drop. Layout studies and detailed mechanical and structural design were performed to obtain a flight-type packaging arrangement, including the close-coupled integration of the BHXU-Alternate with the Brayton Rotating Unit (BRU).

Alternating-current conductivity and dielectric relaxation of bulk iodoargentate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duan, Hai-Bao, E-mail: duanhaibao4660@163.com; Yu, Shan-Shan; Zhou, Hong

Graphical abstract: The electric modulus shows single dielectric relaxation process in the measured frequency range. - Highlights: • The conduction mechanism is described by quantum mechanical tunneling model. • The applications of dielectric modulus give a simple method for evaluating the activation energy of the dielectric relaxation. • The [Ag{sub 2}I{sub 4}]{sup 2−}1-D chain and [Cu(en){sub 2}]{sup 2+} cation column form the layered stacks by hydrogen bond interactions. - Abstract: An inorganic-organic hybrid compound Cu(en){sub 2}Ag{sub 2}I{sub 4} (en = ethylenediamine) (1) was synthesized and single crystal structurally characterized. Along the [001] direction, the inorganic parts form an infinite 1-Dmore » chain and [Cu(en){sub 2}]{sup 2+} cations are separated by inorganic chain. The electrical conductivity and dielectric properties of 1 have been investigated over wide ranges of frequency. The alternating-current conductivities have been fitted to the Almond–West type power law expression with use of a single value of S. It is found that S values for 1 are nearly temperature-independent, which indicates that the conduction mechanism could be quantum mechanical tunneling (QMT) model. The dielectric loss and electric modulus show single dielectric relaxation process. The activation energy obtained from temperature-dependent electric modulus compare with the calculated from the dc conductivity plots.« less

An alternative to FASTSIM for tangential solution of the wheel-rail contact

NASA Astrophysics Data System (ADS)

Sichani, Matin Sh.; Enblom, Roger; Berg, Mats

2016-06-01

In most rail vehicle dynamics simulation packages, tangential solution of the wheel-rail contact is gained by means of Kalker's FASTSIM algorithm. While 5-25% error is expected for creep force estimation, the errors of shear stress distribution, needed for wheel-rail damage analysis, may rise above 30% due to the parabolic traction bound. Therefore, a novel algorithm named FaStrip is proposed as an alternative to FASTSIM. It is based on the strip theory which extends the two-dimensional rolling contact solution to three-dimensional contacts. To form FaStrip, the original strip theory is amended to obtain accurate estimations for any contact ellipse size and it is combined by a numerical algorithm to handle spin. The comparison between the two algorithms shows that using FaStrip improves the accuracy of the estimated shear stress distribution and the creep force estimation in all studied cases. In combined lateral creepage and spin cases, for instance, the error in force estimation reduces from 18% to less than 2%. The estimation of the slip velocities in the slip zone, needed for wear analysis, is also studied. Since FaStrip is as fast as FASTSIM, it can be an alternative for tangential solution of the wheel-rail contact in simulation packages.

Nanostructured Thin Films Obtained from Fischer Aminocarbene Complexes

PubMed Central

Lazo-Jiménez, Rosa E.; Ortega-Alfaro, M. Carmen; López-Cortés, José G.; Alvarez-Toledano, Cecilio; Chávez-Carvayar, José Á.; Ignés-Mullol, Jordi; González-Torres, Maykel; Carreón-Castro, Pilar

2016-01-01

The synthesis of four amphiphilic organometallic complexes with the general formula RC = M(CO)5NH(CH2)15CH3, where R is a ferrocenyl 2(a-b) or a phenyl 4(a-b) group as a donor moiety and a Fischer carbene of chromium (0) or tungsten (0) as an acceptor group, are reported. These four push-pull systems formed Langmuir (L) monolayers at the air-water interface, which were characterized by isotherms of surface pressure versus molecular area and compression/expansion cycles (hysteresis curves); Brewster angle microscopic images were also obtained. By using the Langmuir–Blodgett (LB) method, molecular monolayers were transferred onto glass substrates forming Z-type multilayers. LB films were characterized through ultraviolet-visible spectroscopy, atomic force microscopy and X-ray diffraction techniques. Results indicated that films obtained from 2b complex [(Ferrocenyl)(hexadecylamine)methylidene] pentacarbonyl tungsten (0) are the most stable and homogeneous; due to their properties, these materials may be incorporated into organic electronic devices. PMID:28773289

Generalized alternating stimulation: a novel method to reduce stimulus artifact in electrically evoked compound action potentials.

PubMed

Alvarez, Isaac; de la Torre, Angel; Sainz, Manuel; Roldan, Cristina; Schoesser, Hansjoerg; Spitzer, Philipp

2007-09-15

Stimulus artifact is one of the main limitations when considering electrically evoked compound action potential for clinical applications. Alternating stimulation (average of recordings obtained with anodic-cathodic and cathodic-anodic bipolar stimulation pulses) is an effective method to reduce stimulus artifact when evoked potentials are recorded. In this paper we extend the concept of alternating stimulation by combining anodic-cathodic and cathodic-anodic recordings with a weight in general different to 0.5. We also provide an automatic method to obtain an estimation of the optimal weights. Comparison with conventional alternating, triphasic stimulation and masker-probe paradigm shows that the generalized alternating method improves the quality of electrically evoked compound action potential responses.

Categorization of Alternative Conceptions in Electricity and Magnetism: The Case of Ethiopian Undergraduate Students

ERIC Educational Resources Information Center

Dega, Bekele Gashe; Kriek, Jeanne; Mogese, Temesgen Fereja

2013-01-01

The purpose of this study was to categorize 35 Ethiopian undergraduate physics students' alternative conceptions in the concepts of electric potential and energy. A descriptive qualitative research design was used to categorize the students' alternative conceptions. Four independently homogeneous ability focus groups were formed to elicit the…

Antibodies Against Three Forms of Urokinase

NASA Technical Reports Server (NTRS)

Morrison, Dennis R.; Atassi, M. Zouhair

2007-01-01

Antibodies that bind to preselected regions of the urokinase molecule have been developed. These antibodies can be used to measure small quantities of each of three molecular forms of urokinase that could be contained in microsamples or conditioned media harvested from cultures of mammalian cells. Previously available antibodies and assay techniques do not yield both clear distinctions among, and measurements of, all three forms. Urokinase is a zymogen that is synthesized in a single-chain form, called ScuPA, which is composed of 411 amino acid residues (see figure). ScuPA has very little enzyme activity, but it can be activated in two ways: (1) by cleavage of the peptide bond lysine 158/isoleucine 159 and the loss of lysine 158 to obtain the high molecular-weight (HMW) form of the enzyme or (2) by cleavage of the bond lysine 135/lysine 136 to obtain the low-molecular-weight (LMW) form of the enzyme. The antibodies in question were produced in mice and rabbits by use of peptides as immunogens. The peptides were selected to obtain antibodies that bind to regions of ScuPA that include the lysine 158/isoleucine 159 and the lysine 135/lysine 136 bonds. The antibodies include monoclonal and polyclonal ones that yield indications as to whether either of these bonds is intact. The polyclonal antibodies include ones that preferentially bind to the HMW or LMW forms of the urokinase molecule. The monoclonal antibodies include ones that discriminate between the ScuPA and the HMW form. A combination of these molecular-specific antibodies will enable simultaneous assays of the ScuPA, HMW, and LMW forms in the same specimen of culture medium.

[Evaluation of soy bean proteins obtained by pressure].

PubMed

Bau, H M; Poullain, B; Debry, G

1978-01-01

Besides the processes of extrusion and protein fiber spinning, analogous utilization research with a range of protein sources is continuing at an accelerated pace. However, the pressure forming process, an attractive process for producing protein foods, has not received the attention as it merits. The fabrication techniques contribute the advantages of nutritional value, economic and simplicity in manufacture; it can be extend to utilize in the development of useful textured vegetable protein foods. Here, we present a pressure forming process for producing protein foods with soybean grains. In this paper, we evaluated the composition, and the yield of the products obtained by this process; the trypsin inhibitor and enzymatic proteolyse of the products were also studied. The product obtained contents soluble and insoluble proteins of soybean, 45 p. 100 of protein (N x 6,25), 20-25 p. 100 of carbohydrates of which the fibers are included; moreover it contents 6-7 p. 100 of ash and 20-22 p. 100 of fat. It does not content any starch, the oligosaccharides and antinutritional factors were almost eliminated. This product presents in acceptable textural form resembling traditional animal protein foodstuffs; its fonctional and nutritional properties can meet different utilizations in foodstuffs such as dietetic products and protein complements.

Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure

PubMed Central

Shen, Manli; Bellaousov, Stanislav; Hiller, Michael; de La Grange, Pierre; Creamer, Trevor P.; Malina, Orit; Sperling, Ruth; Mathews, David H.; Stoilov, Peter; Stamm, Stefan

2013-01-01

The serotonin receptor 2C plays a central role in mood and appetite control. It undergoes pre-mRNA editing as well as alternative splicing. The RNA editing suggests that the pre-mRNA forms a stable secondary structure in vivo. To identify substances that promote alternative exons inclusion, we set up a high-throughput screen and identified pyrvinium pamoate as a drug-promoting exon inclusion without editing. Circular dichroism spectroscopy indicates that pyrvinium pamoate binds directly to the pre-mRNA and changes its structure. SHAPE (selective 2′-hydroxyl acylation analysed by primer extension) assays show that part of the regulated 5′-splice site forms intramolecular base pairs that are removed by this structural change, which likely allows splice site recognition and exon inclusion. Genome-wide analyses show that pyrvinium pamoate regulates >300 alternative exons that form secondary structures enriched in A–U base pairs. Our data demonstrate that alternative splicing of structured pre-mRNAs can be regulated by small molecules that directly bind to the RNA, which is reminiscent to an RNA riboswitch. PMID:23393189

Alternative Fuels Data Center: About the Alternative Fuels Data Center

Science.gov Websites

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Structure of Cu/Ni Nanowires Obtained by Matrix Synthesis

NASA Astrophysics Data System (ADS)

Zhigalina, O. M.; Doludenko, I. M.; Khmelenin, D. N.; Zagorskiy, D. L.; Bedin, S. A.; Ivanov, I. M.

2018-05-01

The structure of layered Cu/Ni nanowires obtained by template synthesis in 100-nm channels of track membranes has been investigated by transmission and scanning electron microscopy. The phase composition and main structural features of individual nanowires are determined. It is shown that nanowires consist of alternating Ni ( Fm3m) and Cu ( Fm3m) layers with grains up to 100 nm in size. It is found that nanowires contain also copper oxide crystallites up to 20 nm in size. The elemental composition of individual layers and their mutual arrangement are determined.

12 CFR 18.5 - Alternative annual disclosure statements.

Code of Federal Regulations, 2010 CFR

2010-01-01

...'s consolidated financial statements on Form FR Y-9c pursuant to Regulation Y of the Federal Reserve... FINANCIAL AND OTHER INFORMATION BY NATIONAL BANKS § 18.5 Alternative annual disclosure statements. The § 18... to be elected; (b) In the case of a national bank with audited financial statements, by those...

Persons with allergy symptoms use alternative medicine more often.

PubMed

Kłak, Anna; Raciborski, Filip; Krzych-Fałta, Edyta; Opoczyńska-Świeżewska, Dagmara; Szymański, Jakub; Lipiec, Agnieszka; Piekarska, Barbara; Sybilski, Adam; Tomaszewska, Aneta; Samoliński, Bolesław

2016-01-01

The aim of the study is to indicate the relation between the use of alternative medicine and the occurrence of allergic diseases in the Polish population of adults in the age of 20-44 years. Moreover the additional aim of the study is to define the relation between the sex, age and place of living and the use of alternative medicine. The data from the project Epidemiology of Allergic Diseases in Poland (ECAP) has been used for analysis. This project was a continuation of the European Community Respiratory Health Survey II. The questions on alternative medicine were asked to the group of 4671 respondents in the age of 20-44 years. Additionally outpatient tests were performed in order to confirm the diagnosis of allergic diseases. The total of 22.2% of respondents that participated in the study have ever used alternative medicine (n = 4621). A statistically significant relation between the use of alternative medicine and declaration of allergic diseases and asthma symptoms has been demonstrated (p &amp;amp;amp;amp;amp;lt; 0.001). No statistically significant relation between the use of alternative medicine by persons diagnosed by a doctor with any form of asthma or seasonal allergic rhinitis (p &amp;amp;amp;amp;amp;gt; 0.05) has been demonstrated. The occurrence of allergic diseases and asthma influences the frequency of alternative medicine use. However the frequency of alternative medicine use does not depend on allergic disease or asthma being confirmed by a doctor.

48 CFR 3033.214 - Alternative dispute resolution (ADR).

Code of Federal Regulations, 2010 CFR

2010-10-01

... resolution (ADR). 3033.214 Section 3033.214 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND..., DISPUTES, AND APPEALS Disputes and Appeals 3033.214 Alternative dispute resolution (ADR). (c) The... informal resolution of disputes, and for other purposes. CBCA guidance on ADR may be obtained at http://www...

48 CFR 3033.214 - Alternative dispute resolution (ADR).

Code of Federal Regulations, 2011 CFR

2011-10-01

... resolution (ADR). 3033.214 Section 3033.214 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND..., DISPUTES, AND APPEALS Disputes and Appeals 3033.214 Alternative dispute resolution (ADR). (c) The... informal resolution of disputes, and for other purposes. CBCA guidance on ADR may be obtained at http://www...

Alternating method applied to edge and surface crack problems

NASA Technical Reports Server (NTRS)

Hartranft, R. J.; Sih, G. C.

1972-01-01

The Schwarz-Neumann alternating method is employed to obtain stress intensity solutions to two crack problems of practical importance: a semi-infinite elastic plate containing an edge crack which is subjected to concentrated normal and tangential forces, and an elastic half space containing a semicircular surface crack which is subjected to uniform opening pressure. The solution to the semicircular surface crack is seen to be a significant improvement over existing approximate solutions. Application of the alternating method to other crack problems of current interest is briefly discussed.

Molecular analysis of alternative transcripts of equine AXL receptor tyrosine kinase gene.

PubMed

Park, Jeong-Woong; Song, Ki-Duk; Kim, Nam Young; Choi, Jae-Young; Hong, Seul A; Oh, Jin Hyeog; Kim, Si Won; Lee, Jeong Hyo; Park, Tae Sub; Kim, Jin-Kyoo; Kim, Jong Geun; Cho, Byung-Wook

2017-10-01

Since athletic performance is a most importance trait in horses, most research focused on physiological and physical studies of horse athletic abilities. In contrast, the molecular analysis as well as the regulatory pathway studies remain insufficient for evaluation and prediction of horse athletic abilities. In our previous study, we identified AXL receptor tyrosine kinase ( AXL ) gene which was expressed as alternative spliced isoforms in skeletal muscle during exercise. In the present study, we validated two AXL alternative splicing transcripts (named as AXLa for long form and AXLb for short form) in equine skeletal muscle to gain insight(s) into the role of each alternative transcript during exercise. We validated two isoforms of AXL transcripts in horse tissues by reverse transcriptase polymerase chain reaction (RT-PCR), and then cloned the transcripts to confirm the alternative locus and its sequences. Additionally, we examined the expression patterns of AXLa and AXLb transcripts in horse tissues by quantitative RT-PCR (qRT-PCR). Both of AXLa and AXLb transcripts were expressed in horse skeletal muscle and the expression levels were significantly increased after exercise. The sequencing analysis showed that there was an alternative splicing event at exon 11 between AXLa and AXLb transcripts. 3-dimentional (3D) prediction of the alternative protein structures revealed that the structural distance of the connective region between fibronectin type 3 (FN3) and immunoglobin (Ig) domain was different between two alternative isoforms. It is assumed that the expression patterns of AXLa and AXLb transcripts would be involved in regulation of exercise-induced stress in horse muscle possibly through an NF-κB signaling pathway. Further study is necessary to uncover biological function(s) and significance of the alternative splicing isoforms in race horse skeletal muscle.

Electrodeposition of Nanocrystalline Co-P Coatings as a Hard Chrome Alternative

DTIC Science & Technology

2009-09-02

Electrodeposition  of Nanocrystalline Co‐P  Coatings as a Hard Chrome Alternative Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden...AND SUBTITLE Electrodeposition of Nanocrystalline Co‐P Coatings as a Hard Chrome Alternative 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c...Defense Conference – 2 September 2009 Conventional  Electrodeposits Polycrystalline (10‐100 µm) Electrodeposited Nanocrystalline Materials Pulsed

Influence of preconsolidation on consolidation quality after stamp forming of C/PEEK composites

NASA Astrophysics Data System (ADS)

Slange, T. K.; Warnet, L.; Grouve, W. J. B.; Akkerman, R.

2016-10-01

Stamp forming is a rapid manufacturing technology used to shape flat blanks of thermoplastic composite material into three-dimensional components. Currently, expensive autoclave and press consolidation are used to preconsolidate blanks. This study investigates the influence of preconsolidation on final consolidation quality after stamp forming and explores the potential of alternative blank manufacturing methods that could reduce part costs. Blanks were manufactured using various blank manufacturing methods and subsequently were stamp formed. The consolidation quality both before and after stamp forming was compared, where the focus was on void content as the main measure for consolidation quality. The void content was characterized through thickness and density measurements, as well as by microscopy analysis. Results indicate that preconsolidation quality does have an influence on the final consolidation quality. This is due to the severe deconsolidation and limited reconsolidation during stamp forming. Nevertheless, the potential of automated fiber placement and ultrasonic spot welding as alternative blank manufacturing methods was demonstrated.

Electrochemical Cell for Obtaining Oxygen from Carbon Dioxide Atmospheres

NASA Technical Reports Server (NTRS)

Hooker, Matthew; Rast, H. Edward; Rogers, Darren K.; Borja, Luis; Clark, Kevin; Fleming, Kimberly; Mcgurren, Michael; Oldaker, Tom; Sweet, Nanette

1989-01-01

To support human life on the Martian surface, an electrochemical device will be required to obtain oxygen from the carbon dioxide rich atmosphere. The electrolyte employed in such a device must be constructed from extremely thin, dense membranes to efficiently acquire the oxygen necessary to support life. A forming process used industrially in the production of multilayer capacitors and electronic substrates was adapted to form the thin membranes required. The process, known as the tape casting, involves the suspension consisting of solvents and binders. The suspension is passed under a blade, resulting in the production of ceramic membranes between 0.1 and 0.5 mm thick. Once fired, the stabilized zirconia membranes were assembled into the cell design by employing a zirconium phosphate solution as the sealing agent. The resulting ceramic-to-ceramic seals were found to be structurally sound and gas-tight. Furthermore, by using a zirconia-based solution to assemble the cell, the problem of a thermal expansion mismatch was alleviated. By adopting an industrial forming process to produce thin membranes, an electrochemical cell for obtaining oxygen from carbon dioxide was produced. The proposed cell design is unique in that it does not require a complicated manifold system for separating the various gases present in this process, nor does it require a series of complex electrical connections. Thus, the device can reliably obtain the vital oxygen supply from the toxic carbon dioxide atmosphere.

A Survey of Student Rights in a Public and Alternative High School.

ERIC Educational Resources Information Center

Ogletree, Earl J.; Bryant, Valarie A.

An inner-city alternative high school in Chicago was established for older black teenagers who had dropped out or did not wish to attend public schools. Alternative high school students (N=100) were surveyed to compare their opinions on student rights with those of black inner-city public high school students (N=200) obtained in an earlier study.…

Alternative medicine use in dialysis patients: potential for good and bad!

PubMed

Duncan, Heather J; Pittman, Susan; Govil, Amit; Sorn, Lisa; Bissler, Gloria; Schultz, Tersea; Faith, J; Kant, Shashi; Roy-Chaudhury, Prabir

2007-01-01

Although alternative medicines are widely used within the general population, the extent of their use within the dialysis population is unknown. It is possible that dialysis patients may be more likely to turn towards alternative therapies in view of the chronicity of their disease. In addition, this particular patient population could be at an increased risk of toxicity from these therapies due to an absence of renal excretion. A detailed assessment of complementary and alternative medicine use in our dialysis patients revealed that 18% of our patients had used or were using some form of alternative medicine therapy. An additional 63% of our patients, however, were willing to use a complementary or alternative medication. Our results suggest that hemodialysis patients are extremely receptive to the use of such therapies and are therefore exposed to all their potential benefit and harm. Copyright 2007 S. Karger AG, Basel.

Summation in Autoshaping with Compounds Formed by the Rapid Alternation of Elements

ERIC Educational Resources Information Center

Gomez-Sancho, Luis E.; Fernandez-Serra, Francisco; Arias, M. Francisca

2013-01-01

Summation is the usual result in composition procedures with excitatory stimuli. However, summation is difficult to obtain in autoshaping with pigeons. The problems with this preparation have been related to the stimuli used: combinations of intramodal conditioned stimuli (CSs). During the perceptual processing of this type of stimuli, some mutual…

Alternative RNA Splicing of CSF3R in Promoting Myelodysplastic Syndromes

DTIC Science & Technology

2017-01-01

Myelodysplastic Syndromes, Bone Marrow Failure, Granulopoiesis, RNA splicing 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES...major distinguishing feature of myelodysplastic syndromes (MDS), the most common form of acquired bone marrow failure, is the presence of recurrent...model by expressing alternative splice form in the context of Csf3r-/- mice. KEYWORDS: Myelodysplastic Syndromes, Bone Marrow Failure

A heuristic way of obtaining the Kerr metric

DOE Office of Scientific and Technical Information (OSTI.GOV)

Enderlein, J.

1997-09-01

An intuitive, straightforward way of finding the metric of a rotating black hole is presented, based on the algebra of differential forms. The representation obtained for the metric displays a simplicity which is not obvious in the usual Boyer{endash}Lindquist coordinates. {copyright} {ital 1997 American Association of Physics Teachers.}

Alternative Fuels Data Center: Buying and Selling Pre-Owned Alternative

Science.gov Websites

Alternative Fuels Data Center: Buying and Selling Pre-Owned Alternative Fuel and Advanced Vehicles to someone by E-mail Share Alternative Fuels Data Center: Buying and Selling Pre-Owned Alternative Fuel and Advanced Vehicles on Facebook Tweet about Alternative Fuels Data Center: Buying and Selling Pre-Owned

Effect of geometrical configuration of sediment replenishment on the development of bed form patterns in a gravel bed channel

NASA Astrophysics Data System (ADS)

Battisacco, Elena; Franca, Mário J.; Schleiss, Anton J.

2016-04-01

Dams interrupt the longitudinal continuity of river reaches since they store water and trap sediment in the upstream reservoir. By the interruption of the sediment continuum, the transport capacity of downstream stretch exceeds the sediment supply, thus the flow becomes "hungry". Sediment replenishment is an increasingly used method for restoring the continuity in rivers and for re-establishing the sediment regime of such disturbed river reaches. This research evaluates the effect of different geometrical configurations of sediment replenishment on the evolution of the bed morphology by systematic laboratory experiments. A typical straight armoured gravel reach is reproduced in a laboratory flume in terms of slope, grain size and cross section. The total amount of replenished sediment is placed in four identical volumes on both channel banks, forming six different geometrical configurations. Both alternated and parallel combinations are studied. Preliminary studies demonstrate that a complete submergence condition of the replenishment deposits is most adequate for obtaining a complete erosion and a high persistence of the replenished material in the channel. The response of the channel bed morphology to replenishment is documented by camera and laser scanners installed on a moveable carriage. The parallel configurations create an initially strong narrowing of the channel section. The transport capacity is thus higher and most of the replenished sediments exit the channel. The parallel configurations result in a more spread distribution of grains but with no clear morphological pattern. Clear bed form patterns can be observed when applying alternated configurations. Furthermore, the wavelength of depositions correspond to the replenishment deposit length. These morphological forms can be assumed as mounds. In order to enhance channel bed morphology on an armoured bed by sediment replenishment, alternated deposit configurations are more favourable and effective. The

Weight propagation and equivalent horsepower for alternate-engined cars

NASA Technical Reports Server (NTRS)

Klose, G. J.; Kurtz, D. W.

1978-01-01

In order to evaluate properly the consequences of replacing conventional Otto-cycle engines with alternate power systems, comparisons must be carried out at the vehicle level with functionally equivalent cars. This paper presents the development and application of a procedure for establishing equivalent vehicles. A systematic weight propagation methodology, based on detailed weight breakdowns and influence factors, yields the vehicle weight impacts due to changes in engine weight and power. Performance-matching criteria, utilizing a vehicle simulation program, are then employed to establish Otto-engine-equivalent vehicles, whose characteristics can form the basis for alternative engine evaluations.

Adaptive thermal control of stem gravitropism through alternative RNA splicing in Arabidopsis

PubMed Central

Ryu, Jae Yong; Kim, Joo-Young; Park, Chung-Mo

2015-01-01

Gravitropism is an important growth movement in response to gravity in virtually all higher plants: the roots showing positive gravitropism and the shoots showing negative gravitropism. The gravitropic orientation of plant organs is also influenced by environmental factors, such as light and temperature. It is known that a zinc finger (ZF)-containing transcription factor SHOOT GRAVITROPISM 5/INDETERMINATE DOMAIN 15 (SGR5/IDD15) mediates the early events of gravitropic responses occurring in inflorescence stems. We have recently found that SGR5 gene undergoes alternative splicing to produce 2 protein variants, the full-size SGR5α transcription factor and the truncated SGR5β form lacking functional ZF motifs. The SGR5β form inhibits SGR5α function possibly by forming nonfunctional heterodimers that are excluded from DNA binding. Notably, SGR5 alternative splicing is accelerated at high temperatures, resulting in a high-level accumulation of SGR5β proteins. Accordingly, transgenic plants overexpressing SGR5β exhibit a reduction in the negative gravitropism of inflorescence stems, as observed in the SGR5-defective mutant. It is proposed that the thermos-responsive alternative splicing of SGR5 gene provides an adaptation strategy by which plants protect the shoots from aerial heat frequently occurring in natural habitats. PMID:26452406

Adaptive thermal control of stem gravitropism through alternative RNA splicing in Arabidopsis.

PubMed

Ryu, Jae Yong; Kim, Joo-Young; Park, Chung-Mo

2015-01-01

Gravitropism is an important growth movement in response to gravity in virtually all higher plants: the roots showing positive gravitropism and the shoots showing negative gravitropism. The gravitropic orientation of plant organs is also influenced by environmental factors, such as light and temperature. It is known that a zinc finger (ZF)-containing transcription factor SHOOT GRAVITROPISM 5/INDETERMINATE DOMAIN 15 (SGR5/IDD15) mediates the early events of gravitropic responses occurring in inflorescence stems. We have recently found that SGR5 gene undergoes alternative splicing to produce 2 protein variants, the full-size SGR5α transcription factor and the truncated SGR5β form lacking functional ZF motifs. The SGR5β form inhibits SGR5α function possibly by forming nonfunctional heterodimers that are excluded from DNA binding. Notably, SGR5 alternative splicing is accelerated at high temperatures, resulting in a high-level accumulation of SGR5β proteins. Accordingly, transgenic plants overexpressing SGR5β exhibit a reduction in the negative gravitropism of inflorescence stems, as observed in the SGR5-defective mutant. It is proposed that the thermos-responsive alternative splicing of SGR5 gene provides an adaptation strategy by which plants protect the shoots from aerial heat frequently occurring in natural habitats.

Forming-free performance of a-SiN x :H-based resistive switching memory obtained by oxygen plasma treatment.

PubMed

Zhang, Xinxin; Ma, Zhongyuan; Zhang, Hui; Liu, Jian; Yang, Huafeng; Sun, Yang; Tan, Dinwen; Li, Wei; Xu, Ling; Chen, Kuiji; Feng, Duan

2018-06-15

An a-SiN x -based resistive random access memory (RRAM) device with a forming-free characteristic has significant potentials for the industrialization of the next-generation memories. We demonstrate that a forming-free a-SiN x O y RRAM device can be achieved by an oxygen plasma treatment of ultra-thin a-SiN x :H films. Electron spin resonance spectroscopy reveals that Si dangling bonds with a high density (10 19 cm -3 ) are distributed in the initial state, which exist in the forms of Si 2 N≡Si·, SiO 2 ≡Si·, O 3 ≡Si·, and N 3 ≡Si·. X-ray photoelectron spectroscopy and temperature-dependent current analyses reveal that the silicon dangling bonds induced by the oxygen plasma treatment and external electric field contribute to the low resistance state (LRS). For the high resistance state (HRS), the rupture of the silicon dangling bond pathway is attributed to the partial passivation of Si dangling bonds by H + and O 2- . Both LRS and HRS transmissions obey the hopping conduction model. The proposed oxygen plasma treatment, introduced to generate a high density of Si dangling bonds in the SiN x O y :H films, provides a new approach to forming-free RRAM devices.

Forming-free performance of a-SiN x :H-based resistive switching memory obtained by oxygen plasma treatment

NASA Astrophysics Data System (ADS)

Zhang, Xinxin; Ma, Zhongyuan; Zhang, Hui; Liu, Jian; Yang, Huafeng; Sun, Yang; Tan, Dinwen; Li, Wei; Xu, Ling; Chen, Kuiji; Feng, Duan

2018-06-01

An a-SiN x -based resistive random access memory (RRAM) device with a forming-free characteristic has significant potentials for the industrialization of the next-generation memories. We demonstrate that a forming-free a-SiN x O y RRAM device can be achieved by an oxygen plasma treatment of ultra-thin a-SiN x :H films. Electron spin resonance spectroscopy reveals that Si dangling bonds with a high density (1019 cm‑3) are distributed in the initial state, which exist in the forms of Si2N≡Si·, SiO2≡Si·, O3≡Si·, and N3≡Si·. X-ray photoelectron spectroscopy and temperature-dependent current analyses reveal that the silicon dangling bonds induced by the oxygen plasma treatment and external electric field contribute to the low resistance state (LRS). For the high resistance state (HRS), the rupture of the silicon dangling bond pathway is attributed to the partial passivation of Si dangling bonds by H+ and O2‑. Both LRS and HRS transmissions obey the hopping conduction model. The proposed oxygen plasma treatment, introduced to generate a high density of Si dangling bonds in the SiN x O y :H films, provides a new approach to forming-free RRAM devices.

Conservation-form equations of unsteady open-channel flow

USGS Publications Warehouse

Lai, C.; Baltzer, R.A.; Schaffranek, R.W.

2002-01-01

The unsteady open-channel flow equations are typically expressed in a variety of forms due to the imposition of differing assumptions, use of varied dependent variables, and inclusion of different source/sink terms. Questions often arise as to whether a particular equation set is expressed in a form consistent with the conservation-law definition. The concept of conservation form is developed to clarify the meaning mathematically. Six sets of unsteady-flow equations typically used in engineering practice are presented and their conservation properties are identified and discussed. Results of the theoretical development and analysis of the equations are substantiated in a set of numerical experiments conducted using alternate equation forms. Findings of these analytical and numerical efforts demonstrate that the choice of dependent variable is the fundamental factor determining the nature of the conservation properties of any particular equation form.

17 CFR 242.301 - Requirements for alternative trading systems.

Code of Federal Regulations, 2010 CFR

2010-04-01

... determining that such an order is consistent with the public interest, the protection of investors, and the... alternative trading system. (iii) If any information contained in the initial operation report filed under... on Form ATS correcting such information within 30 calendar days after the end of each calendar...

40 CFR 372.95 - Alternate threshold certification and instructions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 29 2012-07-01 2012-07-01 false Alternate threshold certification and instructions. 372.95 Section 372.95 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS TOXIC CHEMICAL RELEASE REPORTING: COMMUNITY RIGHT-TO-KNOW Forms and...

40 CFR 372.95 - Alternate threshold certification and instructions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 28 2014-07-01 2014-07-01 false Alternate threshold certification and instructions. 372.95 Section 372.95 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS TOXIC CHEMICAL RELEASE REPORTING: COMMUNITY RIGHT-TO-KNOW Forms and...

40 CFR 372.95 - Alternate threshold certification and instructions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 28 2011-07-01 2011-07-01 false Alternate threshold certification and instructions. 372.95 Section 372.95 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS TOXIC CHEMICAL RELEASE REPORTING: COMMUNITY RIGHT-TO-KNOW Forms and...

40 CFR 372.95 - Alternate threshold certification and instructions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 27 2010-07-01 2010-07-01 false Alternate threshold certification and instructions. 372.95 Section 372.95 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS TOXIC CHEMICAL RELEASE REPORTING: COMMUNITY RIGHT-TO-KNOW Forms and...

48 CFR 1332.702-70 - Forms.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Forms. 1332.702-70 Section 1332.702-70 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Funding 1332.702-70 Forms. Contracting officers must obtain an...

Evolution and Multifarious Horizontal Transfer of an Alternative Biosynthetic Pathway for the Alternative Polyamine sym-Homospermidine*♦

PubMed Central

Shaw, Frances L.; Elliott, Katherine A.; Kinch, Lisa N.; Fuell, Christine; Phillips, Margaret A.; Michael, Anthony J.

2010-01-01

Polyamines are small flexible organic polycations found in almost all cells. They likely existed in the last universal common ancestor of all extant life, and yet relatively little is understood about their biological function, especially in bacteria and archaea. Unlike eukaryotes, where the predominant polyamine is spermidine, bacteria may contain instead an alternative polyamine, sym-homospermidine. We demonstrate that homospermidine synthase (HSS) has evolved vertically, primarily in the α-Proteobacteria, but enzymatically active, diverse HSS orthologues have spread by horizontal gene transfer to other bacteria, bacteriophage, archaea, eukaryotes, and viruses. By expressing diverse HSS orthologues in Escherichia coli, we demonstrate in vivo the production of co-products diaminopropane and N1-aminobutylcadaverine, in addition to sym-homospermidine. We show that sym-homospermidine is required for normal growth of the α-proteobacterium Rhizobium leguminosarum. However, sym-homospermidine can be replaced, for growth restoration, by the structural analogues spermidine and sym-norspermidine, suggesting that the symmetrical or unsymmetrical form and carbon backbone length are not critical for polyamine function in growth. We found that the HSS enzyme evolved from the alternative spermidine biosynthetic pathway enzyme carboxyspermidine dehydrogenase. The structure of HSS is related to lysine metabolic enzymes, and HSS and carboxyspermidine dehydrogenase evolved from the aspartate family of pathways. Finally, we show that other bacterial phyla such as Cyanobacteria and some α-Proteobacteria synthesize sym-homospermidine by an HSS-independent pathway, very probably based on deoxyhypusine synthase orthologues, similar to the alternative homospermidine synthase found in some plants. Thus, bacteria can contain alternative biosynthetic pathways for both spermidine and sym-norspermidine and distinct alternative pathways for sym-homospermidine. PMID:20194510

A program to form a multidisciplinary data base and analysis for dynamic systems

NASA Technical Reports Server (NTRS)

Taylor, L. W.; Suit, W. T.; Mayo, M. H.

1984-01-01

Diverse sets of experimental data and analysis programs have been assembled for the purpose of facilitating research in systems identification, parameter estimation and state estimation techniques. The data base analysis programs are organized to make it easy to compare alternative approaches. Additional data and alternative forms of analysis will be included as they become available.

41 CFR 102-74.595 - How can agencies obtain guidance, assistance, and oversight regarding alternative workplace...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Section 102-74.595 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 74-FACILITY MANAGEMENT Telework § 102-74.595 How can... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false How can agencies obtain...

In Vitro Study of Taenia solium Postoncospheral Form.

PubMed

Chile, Nancy; Clark, Taryn; Arana, Yanina; Ortega, Ynes R; Palma, Sandra; Mejia, Alan; Angulo, Noelia; Kosek, Jon C; Kosek, Margaret; Gomez-Puerta, Luis A; Garcia, Hector H; Gavidia, Cesar M; Gilman, Robert H; Verastegui, Manuela

2016-02-01

The transitional period between the oncosphere and the cysticercus of Taenia solium is the postoncospheral (PO) form, which has not yet been completely characterized. The aim of this work was to standardize a method to obtain T. solium PO forms by in vitro cultivation. We studied the morphology of the PO form and compared the expression of antigenic proteins among the PO form, oncosphere, and cysticerci stages. T. solium activated oncospheres were co-cultured with ten cell lines to obtain PO forms, which we studied at three stages of development--days 15, 30, and 60. A high percentage (32%) of PO forms was obtained using HCT-8 cells in comparison to the other cell lines. The morphology was observed by bright field, scanning, and transmission electron microscopy. Morphology of the PO form changed over time, with the six hooks commonly seen in the oncosphere stage disappearing in the PO forms, and vesicles and microtriches observed in the tegument. The PO forms grew as they aged, reaching a diameter of 2.5 mm at 60 days of culture. 15-30 day PO forms developed into mature cysticerci when inoculated into rats. Antigenic proteins expressed in the PO forms are also expressed by the oncosphere and cysticerci stages, with more cysticerci antigenic proteins expressed as the PO forms ages. This is the first report of an in vitro production method of T. solium PO forms. The changes observed in protein expression may be useful in identifying new targets for vaccine development. In vitro culture of PO form will aid in understanding the host-parasite relationship, since the structural changes of the developing PO forms may reflect the parasite's immunoprotective mechanisms. A wider application of this method could significantly reduce the use of animals, and thus the costs and time required for further experimental investigations.

Method and tool for expanding tubular members by electro-hydraulic forming

DOEpatents

Golovashchenko, Sergey Fedorovich; Bonnen, John Joseph Francis

2013-10-29

An electro-hydraulic forming tool having one or more electrodes for forming parts with sharp corners. The electrodes may be moved and sequentially discharged several times to form various areas of the tube. Alternatively, a plurality of electrodes may be provided that are provided within an insulating tube that defines a charge area opening. The insulating tube is moved to locate the charge area opening adjacent one of the electrodes to form spaced locations on a preform. In other embodiments, a filament wire is provided in a cartridge or supported by an insulative support.

Cloning and characterization of an alternative splicing transcript of the gene coding for human cytidine deaminase.

PubMed

Lisboa, Bianca Cristina Garcia; Machado, Tamara da Rocha; Pimenta, Daniel Carvalho; Han, Sang Won

2007-02-01

Human cytidine deaminase (HCD) catalyzes the deamination of cytidine or deoxycytidine to uridine or deoxyuridine, respectively. The genomic sequence of HCD is formed by 31 kb with 4 exons and several alternative splicing signals, but an alternative form of HCD has yet to be reported. Here we describe the cloning and characterization of a small form of HCD, HSCD, and it is likely to be a product of alternative splicing of HCD. The alignment of DNA sequences shows that the HSCD matches HCD in 2 parts, except for a deletion of 170 bp. Based on the HCD genome organization, exons 1 and 4 should be joined and all sequences of introns and exons 2 and 3 should be deleted by splicing. This alternative splicing shifted the translation of the reading frame from the point of splicing. The estimated molecular mass is 9.8 kDa, and this value was confirmed by Western blot and mass spectroscopy after expressing the gene fused with glutathionine-S-transferase in the pGEX vector. The deletion and shift of the reading frame caused a loss of HCD activity, which was confirmed by enzyme assay and also with NIH3T3 cells modified to express HSCD and challenged against cytosine arabinoside. In this work we describe the identification and characterization of HSCD, which is the product of alternative splicing of the HCD gene.

An Alternative Methodology for Creating Parallel Test Forms Using the IRT Information Function.

ERIC Educational Resources Information Center

Ackerman, Terry A.

The purpose of this paper is to report results on the development of a new computer-assisted methodology for creating parallel test forms using the item response theory (IRT) information function. Recently, several researchers have approached test construction from a mathematical programming perspective. However, these procedures require…

The importance of functional form in optimal control solutions of problems in population dynamics

USGS Publications Warehouse

Runge, M.C.; Johnson, F.A.

2002-01-01

Optimal control theory is finding increased application in both theoretical and applied ecology, and it is a central element of adaptive resource management. One of the steps in an adaptive management process is to develop alternative models of system dynamics, models that are all reasonable in light of available data, but that differ substantially in their implications for optimal control of the resource. We explored how the form of the recruitment and survival functions in a general population model for ducks affected the patterns in the optimal harvest strategy, using a combination of analytical, numerical, and simulation techniques. We compared three relationships between recruitment and population density (linear, exponential, and hyperbolic) and three relationships between survival during the nonharvest season and population density (constant, logistic, and one related to the compensatory harvest mortality hypothesis). We found that the form of the component functions had a dramatic influence on the optimal harvest strategy and the ultimate equilibrium state of the system. For instance, while it is commonly assumed that a compensatory hypothesis leads to higher optimal harvest rates than an additive hypothesis, we found this to depend on the form of the recruitment function, in part because of differences in the optimal steady-state population density. This work has strong direct consequences for those developing alternative models to describe harvested systems, but it is relevant to a larger class of problems applying optimal control at the population level. Often, different functional forms will not be statistically distinguishable in the range of the data. Nevertheless, differences between the functions outside the range of the data can have an important impact on the optimal harvest strategy. Thus, development of alternative models by identifying a single functional form, then choosing different parameter combinations from extremes on the likelihood

Working Less and Enjoying It More: Alternative Work Schedules.

ERIC Educational Resources Information Center

Shanks, Katherine

1984-01-01

Explores three forms of alternative work schedules that research has shown improve job performance and decrease absenteeism: flextime (starting and stopping times vary within limits); permanent part-time employment (regular employment carried out during shorter working hours); and job sharing (two or more part-time employees share one full-time…

Alternating and Sequential Motion Rates in Older Adults

ERIC Educational Resources Information Center

Pierce, John E.; Cotton, Susan; Perry, Alison

2013-01-01

Background: Alternating motion rate (AMR) and sequential motion rate (SMR) are tests of articulatory diadochokinesis that are widely used in the evaluation of motor speech. However, there are no quality normative data available for adults aged 65 years and older. Aims: There were two aims: (1) to obtain a representative, normative dataset of…

Effects of alternative silviculture on stump sprouting in the southern Appalachians

Treesearch

Chad Atwood; Thomas Fox; David L. Loftis

2009-01-01

Stump sprouts are an important form of regeneration for a number of species in the southernAppalachians, especially the oaks (Quercus spp.). Alternative regeneration systems to clearcutting suchas shelterwood and leave-tree systems are being implemented...

The development and evaluation of an alternative powder prepregging technique for use with LaRC-TPI/graphite composites

NASA Technical Reports Server (NTRS)

Ogden, Andrea L.; Hyer, Michael W.; Wilkes, Garth L.; Loos, Alfred C.; St.clair, Terry L.

1991-01-01

An alternative powder prepregging method for use with LaRC-TPI (a thermoplastic polyimide)/graphite composites is investigated. The alternative method incorporates the idea of moistening the fiber prior to powder coating. Details of the processing parameters are given and discussed. The material was subsequently laminated into small coupons which were evaluated for processing defects using electron microscopy. After the initial evaluation of the material, no major processing defects were encountered but there appeared to be an interfacial adhesion problem. As a result, prepregging efforts were extended to include an additional fiber system, XAS, and a semicrystalline form of the matrix. The semicrystalline form of the matrix was the result of a complex heat treating cycle. Using scanning electron microscopy (SEM), the fiber/matrix adhesion was evaluated in these systems relative to the amorphous/XAS coupons. Based on these results, amorphous and semicrystalline/AS-4 and XAS materials were prepregged and laminated for transverse tensile testing. The results of these tests are presented, and in an effort to obtain more information on the effect of the matrix, remaining semicrystalline transverse tensile coupons were transformed back to the amorphous state and tested. The mechanical properties of the transformed coupons returned to the values observed for the original amorphous coupons, and the interfacial adhesion, as observed by SEM, was better than in any previous sample.

Compatibility of elastomers in alternate jet fuels

NASA Technical Reports Server (NTRS)

Kalfayan, S. H.; Fedors, R. F.; Reilly, W. W.

1979-01-01

The compatibility of elastomeric compositions of known resistance to aircraft fuels was tested for potential use in Jet A type fuels obtainable from alternate sources, such as coal. Since such fuels were not available at the time, synthetic alternate fuels were prepared by adding tetralin to a petroleum based Jet A type fuel to simulate coal derived fuels which are expected to contain higher amounts of aromatic and hydroaromatic hydrocarbons. The elastomeric compounds tested were based on butadiene-acrylonitrile rubber, a castable Thiokol polysulfide rubber, and a castable fluorosilicone rubber. Batches of various cross-link densities of these rubbers were made and their chemical stress relaxation behavior in fuel, air, and nitrogen, their swelling properties, and response to mechanical testing were determined.

Machining of Silicon-Ribbon-Forming Dies

NASA Technical Reports Server (NTRS)

Menna, A. A.

1985-01-01

Carbon extension for dies used in forming silicon ribbon crystals machined precisely with help of special tool. Die extension has edges beveled toward narrow flats at top, with slot precisely oriented and centered between flats and bevels. Cutting tool assembled from standard angle cutter and circular saw or saws. Angle cutters cuts bevels while slot saw cuts slot between them. In alternative version, custom-ground edges or additional circular saws also cut flats simultaneously.

Diverse alternative back-splicing and alternative splicing landscape of circular RNAs

PubMed Central

Zhang, Xiao-Ou; Dong, Rui; Zhang, Yang; Zhang, Jia-Lin; Luo, Zheng; Zhang, Jun; Chen, Ling-Ling; Yang, Li

2016-01-01

Circular RNAs (circRNAs) derived from back-spliced exons have been widely identified as being co-expressed with their linear counterparts. A single gene locus can produce multiple circRNAs through alternative back-splice site selection and/or alternative splice site selection; however, a detailed map of alternative back-splicing/splicing in circRNAs is lacking. Here, with the upgraded CIRCexplorer2 pipeline, we systematically annotated different types of alternative back-splicing and alternative splicing events in circRNAs from various cell lines. Compared with their linear cognate RNAs, circRNAs exhibited distinct patterns of alternative back-splicing and alternative splicing. Alternative back-splice site selection was correlated with the competition of putative RNA pairs across introns that bracket alternative back-splice sites. In addition, all four basic types of alternative splicing that have been identified in the (linear) mRNA process were found within circRNAs, and many exons were predominantly spliced in circRNAs. Unexpectedly, thousands of previously unannotated exons were detected in circRNAs from the examined cell lines. Although these novel exons had similar splice site strength, they were much less conserved than known exons in sequences. Finally, both alternative back-splicing and circRNA-predominant alternative splicing were highly diverse among the examined cell lines. All of the identified alternative back-splicing and alternative splicing in circRNAs are available in the CIRCpedia database (http://www.picb.ac.cn/rnomics/circpedia). Collectively, the annotation of alternative back-splicing and alternative splicing in circRNAs provides a valuable resource for depicting the complexity of circRNA biogenesis and for studying the potential functions of circRNAs in different cells. PMID:27365365

Development of alternate paragraphs for the Logical Memory subtest of the Wechsler Memory Scale-IV.

PubMed

Morris, Jeri; Swier-Vosnos, Amy; Woodworth, Craig; Umfleet, Laura Glass; Czipri, Sheena; Kopald, Brandon

2014-01-01

The purpose of the two studies included in this article was to validate an alternate form, the Morris Revision-Fourth Edition (MR-IV), to the Logical Memory paragraphs of the Wechsler Memory Scale-Fourth Edition (LM-IV) for use when retesting of individuals is desired. Study I demonstrated high correlation with the LM-IV paragraphs. Study II was a replication that again demonstrated high correlation between the original LM-IV and the new MR-IV paragraphs. High interrater reliability also was demonstrated. Consequently, the MR-IV paragraphs can be considered an alternate form to the LM-IV paragraphs. Although other attempts have been made to develop alternate stories, these new paragraphs are the only ones that are equivalent in structure, affective tone, and number of scorable units. They have considerable clinical utility and research potential.

A study of alternative splicing in the pig

PubMed Central

2010-01-01

Background Since at least half of the genes in mammalian genomes are subjected to alternative splicing, alternative pre-mRNA splicing plays an important contribution to the complexity of the mammalian proteome. Expressed sequence tags (ESTs) provide evidence of a great number of possible alternative isoforms. With the EST resource for the domestic pig now containing more than one million porcine ESTs, it is possible to identify alternative splice forms of the individual transcripts in this species from the EST data with some confidence. Results The pig EST data generated by the Sino-Danish Pig Genome project has been assembled with publicly available ESTs and made available in the PigEST database. Using the Distiller package 2,515 EST clusters with candidate alternative isoforms were identified in the EST data with high confidence. In agreement with general observations in human and mouse, we find putative splice variants in about 30% of the contigs with more than 50 ESTs. Based on the criteria that a minimum of two EST sequences confirmed each splice event, a list of 100 genes with the most distinct tissue-specific alternative splice events was generated from the list of candidates. To confirm the tissue specificity of the splice events, 10 genes with functional annotation were randomly selected from which 16 individual splice events were chosen for experimental verification by quantitative PCR (qPCR). Six genes were shown to have tissue specific alternatively spliced transcripts with expression patterns matching those of the EST data. The remaining four genes had tissue-restricted expression of alternative spliced transcripts. Five out of the 16 splice events that were experimentally verified were found to be putative pig specific. Conclusions In accordance with human and rodent studies we estimate that approximately 30% of the porcine genes undergo alternative splicing. We found a good correlation between EST predicted tissue-specificity and experimentally

Alternative Form of the Hydrogenic Wave Functions for an Extended, Uniformly Charged Nucleus.

ERIC Educational Resources Information Center

Ley-Koo, E.; And Others

1980-01-01

Presented are forms of harmonic oscillator attraction and Coulomb wave functions which can be explicitly constructed and which lead to numerical results for the energy eigenvalues and eigenfunctions of the atomic system. The Schrodinger equation and its solution and specific cases of muonic atoms illustrating numerical calculations are included.…

Alternative Fuel Guidelines for Alternative Transportation Systems.

DOT National Transportation Integrated Search

2011-01-31

The Volpe Center documented the increased use of alternative fuels on vehicles owned and operated by federal land management agencies. For each alternative fuel type, the Volpe Center documented the availability of vehicles, fueling mechanisms and pr...

What happened (and what didn’t): Discourse constraints on encoding of plausible alternatives

PubMed Central

Fraundorf, Scott H.; Benjamin, Aaron S.; Watson, Duane G.

2013-01-01

Three experiments investigated how font emphasis influences reading and remembering discourse. Although past work suggests that contrastive pitch contours benefit memory by promoting encoding of salient alternatives, it is unclear both whether this effect generalizes to other forms of linguistic prominence and how the set of alternatives is constrained. Participants read discourses in which some true propositions had salient alternatives (e.g., British scientists found the endangered monkey when the discourse also mentioned French scientists) and completed a recognition memory test. In Experiments 1 and 2, font emphasis in the initial presentation increased participants’ ability to later reject false statements about salient alternatives but not about unmentioned items (e.g., Portuguese scientists). In Experiment 3, font emphasis helped reject false statements about plausible alternatives, but not about less plausible alternatives that were nevertheless established in the discourse. These results suggest readers encode a narrow set of only those alternatives plausible in the particular discourse. They also indicate that multiple manipulations of linguistic prominence, not just prosody, can lead to consideration of alternatives. PMID:24014934

Method for forming permanent magnets with different polarities for use in microelectromechanical devices

DOEpatents

Roesler, Alexander W [Tijeras, NM; Christenson, Todd R [Albuquerque, NM

2007-04-24

Methods are provided for forming a plurality of permanent magnets with two different north-south magnetic pole alignments for use in microelectromechanical (MEM) devices. These methods are based on initially magnetizing the permanent magnets all in the same direction, and then utilizing a combination of heating and a magnetic field to switch the polarity of a portion of the permanent magnets while not switching the remaining permanent magnets. The permanent magnets, in some instances, can all have the same rare-earth composition (e.g. NdFeB) or can be formed of two different rare-earth materials (e.g. NdFeB and SmCo). The methods can be used to form a plurality of permanent magnets side-by-side on or within a substrate with an alternating polarity, or to form a two-dimensional array of permanent magnets in which the polarity of every other row of the array is alternated.

Obtaining subjects' consent to publish identifying personal information: current practices and identifying potential issues.

PubMed

Yoshida, Akiko; Dowa, Yuri; Murakami, Hiromi; Kosugi, Shinji

2013-11-25

In studies publishing identifying personal information, obtaining consent is regarded as necessary, as it is impossible to ensure complete anonymity. However, current journal practices around specific points to consider when obtaining consent, the contents of consent forms and how consent forms are managed have not yet been fully examined. This study was conducted to identify potential issues surrounding consent to publish identifying personal information. Content analysis was carried out on instructions for authors and consent forms developed by academic journals in four fields (as classified by Journal Citation Reports): medicine general and internal, genetics and heredity, pediatrics, and psychiatry. An online questionnaire survey of editors working for journals that require the submission of consent forms was also conducted. Instructions for authors were reviewed for 491 academic journals (132 for medicine general and internal, 147 for genetics and heredity, 100 for pediatrics, and 112 for psychiatry). Approximately 40% (203: 74 for medicine general and internal, 31 for genetics and heredity, 58 for pediatrics, and 40 for psychiatry) stated that subject consent was necessary. The submission of consent forms was required by 30% (154) of the journals studied, and 10% (50) provided their own consent forms for authors to use. Two journals mentioned that the possible effects of publication on subjects should be considered. Many journal consent forms mentioned the difficulties in ensuring complete anonymity of subjects, but few addressed the study objective, the subjects' right to refuse consent and the withdrawal of consent. The main reason for requiring the submission of consent forms was to confirm that consent had been obtained. Approximately 40% of journals required subject consent to be obtained. However, differences were observed depending on the fields. Specific considerations were not always documented. There is a need to address issues around the study

Obtaining subjects’ consent to publish identifying personal information: current practices and identifying potential issues

PubMed Central

2013-01-01

Background In studies publishing identifying personal information, obtaining consent is regarded as necessary, as it is impossible to ensure complete anonymity. However, current journal practices around specific points to consider when obtaining consent, the contents of consent forms and how consent forms are managed have not yet been fully examined. This study was conducted to identify potential issues surrounding consent to publish identifying personal information. Methods Content analysis was carried out on instructions for authors and consent forms developed by academic journals in four fields (as classified by Journal Citation Reports): medicine general and internal, genetics and heredity, pediatrics, and psychiatry. An online questionnaire survey of editors working for journals that require the submission of consent forms was also conducted. Results Instructions for authors were reviewed for 491 academic journals (132 for medicine general and internal, 147 for genetics and heredity, 100 for pediatrics, and 112 for psychiatry). Approximately 40% (203: 74 for medicine general and internal, 31 for genetics and heredity, 58 for pediatrics, and 40 for psychiatry) stated that subject consent was necessary. The submission of consent forms was required by 30% (154) of the journals studied, and 10% (50) provided their own consent forms for authors to use. Two journals mentioned that the possible effects of publication on subjects should be considered. Many journal consent forms mentioned the difficulties in ensuring complete anonymity of subjects, but few addressed the study objective, the subjects’ right to refuse consent and the withdrawal of consent. The main reason for requiring the submission of consent forms was to confirm that consent had been obtained. Conclusion Approximately 40% of journals required subject consent to be obtained. However, differences were observed depending on the fields. Specific considerations were not always documented. There is a need

Alternative Fuels Data Center: New York Transportation Data for Alternative

Science.gov Websites

Fuels and Vehicles New York Transportation Data for Alternative Fuels and Vehicles to someone by E-mail Share Alternative Fuels Data Center: New York Transportation Data for Alternative Fuels and Vehicles on Facebook Tweet about Alternative Fuels Data Center: New York Transportation Data for

Alternative Fuels Data Center: New York Coalition Helps Local Alternative

Science.gov Websites

Fuel Station Boost Revenue New York Coalition Helps Local Alternative Fuel Station Boost Revenue to someone by E-mail Share Alternative Fuels Data Center: New York Coalition Helps Local Alternative Fuel Station Boost Revenue on Facebook Tweet about Alternative Fuels Data Center: New York

Identification of Average Treatment Effects in Social Experiments under Alternative Forms of Attrition

ERIC Educational Resources Information Center

Huber, Martin

2012-01-01

As any empirical method used for causal analysis, social experiments are prone to attrition which may flaw the validity of the results. This article considers the problem of partially missing outcomes in experiments. First, it systematically reveals under which forms of attrition--in terms of its relation to observable and/or unobservable…

Short-Form Versions of the Spanish MacArthur-Bates Communicative Development Inventories

ERIC Educational Resources Information Center

Jackson-Maldonodo, Donna; Marchman, Virginia A.; Fernald, Lia C. H.

2013-01-01

The Spanish-language MacArthur-Bates Communicative Development Inventories (S-CDIs) are well-established parent report tools for assessing the language development of Spanish-speaking children under 3 years. Here, we introduce the short-form versions of the S-CDIs (SFI and SFII), offered as alternatives to the long forms for screening purposes or…

78 FR 23832 - Labeling Requirements for Alternative Fuels and Alternative Fueled Vehicles

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-23

... Fuels and Alternative Fueled Vehicles AGENCY: Federal Trade Commission (FTC or Commission). ACTION... Alternative Fuels and Alternative Fueled Vehicles'') to consolidate the FTC's alternative fueled vehicle (AFV...) established federal programs to encourage the development of alternative fuels and alternative fueled vehicles...

New strategy to identify radicals in a time evolving EPR data set by multivariate curve resolution-alternating least squares.

PubMed

Fadel, Maya Abou; de Juan, Anna; Vezin, Hervé; Duponchel, Ludovic

2016-12-01

Electron paramagnetic resonance (EPR) spectroscopy is a powerful technique that is able to characterize radicals formed in kinetic reactions. However, spectral characterization of individual chemical species is often limited or even unmanageable due to the severe kinetic and spectral overlap among species in kinetic processes. Therefore, we applied, for the first time, multivariate curve resolution-alternating least squares (MCR-ALS) method to EPR time evolving data sets to model and characterize the different constituents in a kinetic reaction. Here we demonstrate the advantage of multivariate analysis in the investigation of radicals formed along the kinetic process of hydroxycoumarin in alkaline medium. Multiset analysis of several EPR-monitored kinetic experiments performed in different conditions revealed the individual paramagnetic centres as well as their kinetic profiles. The results obtained by MCR-ALS method demonstrate its prominent potential in analysis of EPR time evolved spectra. Copyright © 2016 Elsevier B.V. All rights reserved.

Alternative thermodynamic cycle for the Stirling machine

NASA Astrophysics Data System (ADS)

Romanelli, Alejandro

2017-12-01

We develop an alternative thermodynamic cycle for the Stirling machine, where the polytropic process plays a central role. Analytical expressions for pressure and temperatures of the working gas are obtained as a function of the volume and the parameter that characterizes the polytropic process. This approach achieves closer agreement with the experimental pressure-volume diagram and can be adapted to any type of Stirling engine.

Information technology to support alternative vehicle travel in Yellowstone National Park

DOT National Transportation Integrated Search

2003-10-01

Because of crowding, overuse, and pollution, the National Park Service is conducting a major effort to develop alternative forms of transportation in the national parks. A new generation of busses and trams will provide features that motivate visitor...

Alternative dipole magnets for ISABELLE

NASA Astrophysics Data System (ADS)

Taylor, C.; Althaus, R.; Caspi, S.; Gilbert, W.; Hassenzahl, W. V.; Meuser, R.; Rechen, J.; Warren, R.

1982-05-01

A dipole magnet, intended as a possible alternative for the ISABELLE main ring magnet, was designed. Three layers of FNAL Doubler/Saver conductor were used. Two 1.3-m-long models were built and tested, both with and without an iron core, and in both helium I and helium II. The training behavior, cyclic energy loss, point of quench initiation, and quench velocity were determined. A central field of 6.5 tesla was obtained in He I (4.4 K), and 7.6 tesla in He II (1.8K).

Obtaining lutein-rich extract from microalgal biomass at preparative scale.

PubMed

Fernández-Sevilla, José M; Fernández, F Gabriel Acién; Grima, Emilio Molina

2012-01-01

Lutein extracts are in increasing demand due to their alleged role in the prevention of degenerative disorders such as age-related macular degeneration (AMD). Lutein extracts are currently obtained from plant sources, but microalgae have been demonstrated to be a competitive source likely to become an alternative. The extraction of lutein from microalgae posesses specific problems that arise from the different structure and composition of the source biomass. Here is presented a method for the recovery of lutein-rich carotenoid extracts from microalgal biomass in the kilogram scale.

Alternative AFFF (Aqueous Film Forming Foam) Proportioning Systems for the SSN 21 Design - T&E.

DTIC Science & Technology

1986-06-02

ALTERNAT IVE AFFF PROPORTIONING SYSTEMS FOR THE SSN 21 DESIGN -T&E -. INTRODUCTION The Aqueous Film Formning Foam (AFFI) ’ire sucpression *svstems...k D-R16B 927 RLTERII*TIVE RFFF (ROIJOUS FILM FORMING FORM ) / PROPORTIONING SYSTEMS FOR THE SSN 21 DESIGN -T&E(u) I NAVAL RESEARCH LRB MASHINOTOK DC F...systems. * :.TECl-ICAL DESCRIPTION A. General As now envisioned, the AFFF firefighting systems will be suzolied from the on-board seawater flushing

Exponent and scrambling index of double alternate circular snake graphs

NASA Astrophysics Data System (ADS)

Rahmayanti, Sri; Pasaribu, Valdo E.; Nasution, Sawaluddin; Liani Salnaz, Sishi

2018-01-01

A graph is primitive if it contains a cycle of odd length. The exponent of a primitive graph G, denoted by exp(G), is the smallest positive integer k such that for each pair of vertices u and v in G there is a uv-walk length k. The scrambling index of a primitive graph G, denoted by k(G), is the smallest positive integer k such that for each pair of vertices u and v in G there is a uv-walk of length 2k. For an even positive integer n and an odd positive integer r, a (n,r)-double alternate circular snake graph, denoted by DA(C r,n ), is a graph obtained from a path u 1 u 2 ... u n by replacing each edge of the form u 2i u 2i+1 by two different r-cycles. We study the exponent and scrambling index of DA(C r,n ) and show that exp(DA(C r,n )) = n + r - 4 and k(DA(C r,n )) = (n + r - 3)/2.

Coupling between alternative polyadenylation and alternative splicing is limited to terminal introns.

PubMed

Movassat, Maliheh; Crabb, Tara L; Busch, Anke; Yao, Chengguo; Reynolds, Derrick J; Shi, Yongsheng; Hertel, Klemens J

2016-07-02

Alternative polyadenylation has been implicated as an important regulator of gene expression. In some cases, alternative polyadenylation is known to couple with alternative splicing to influence last intron removal. However, it is unknown whether alternative polyadenylation events influence alternative splicing decisions at upstream exons. Knockdown of the polyadenylation factors CFIm25 or CstF64 in HeLa cells was used as an approach in identifying alternative polyadenylation and alternative splicing events on a genome-wide scale. Although hundreds of alternative splicing events were found to be differentially spliced in the knockdown of CstF64, genes associated with alternative polyadenylation did not exhibit an increased incidence of alternative splicing. These results demonstrate that the coupling between alternative polyadenylation and alternative splicing is usually limited to defining the last exon. The striking influence of CstF64 knockdown on alternative splicing can be explained through its effects on UTR selection of known splicing regulators such as hnRNP A2/B1, thereby indirectly influencing splice site selection. We conclude that changes in the expression of the polyadenylation factor CstF64 influences alternative splicing through indirect effects.

Advances in solid dosage form manufacturing technology.

PubMed

Andrews, Gavin P

2007-12-15

Currently, the pharmaceutical and healthcare industries are moving through a period of unparalleled change. Major multinational pharmaceutical companies are restructuring, consolidating, merging and more importantly critically assessing their competitiveness to ensure constant growth in an ever-more demanding market where the cost of developing novel products is continuously increasing. The pharmaceutical manufacturing processes currently in existence for the production of solid oral dosage forms are associated with significant disadvantages and in many instances provide many processing problems. Therefore, it is well accepted that there is an increasing need for alternative processes to dramatically improve powder processing, and more importantly to ensure that acceptable, reproducible solid dosage forms can be manufactured. Consequently, pharmaceutical companies are beginning to invest in innovative processes capable of producing solid dosage forms that better meet the needs of the patient while providing efficient manufacturing operations. This article discusses two emerging solid dosage form manufacturing technologies, namely hot-melt extrusion and fluidized hot-melt granulation.

Measuring the Impact of an Alternative Approach to School Bullying

ERIC Educational Resources Information Center

Domino, Meg

2013-01-01

Background: National estimates of middle school bullying approximate 40%, making it the leading form of school violence. Meta-analysis of conventional anti-bullying efforts have shown mixed results, averaging small reductions in bullying behavior. Social-Emotional Learning and PositiveYouth Development provide a theory-driven alternative for…

An Alternative Approach to the Extended Drude Model

NASA Astrophysics Data System (ADS)

Gantzler, N. J.; Dordevic, S. V.

2018-05-01

The original Drude model, proposed over a hundred years ago, is still used today for the analysis of optical properties of solids. Within this model, both the plasma frequency and quasiparticle scattering rate are constant, which makes the model rather inflexible. In order to circumvent this problem, the so-called extended Drude model was proposed, which allowed for the frequency dependence of both the quasiparticle scattering rate and the effective mass. In this work we will explore an alternative approach to the extended Drude model. Here, one also assumes that the quasiparticle scattering rate is frequency dependent; however, instead of the effective mass, the plasma frequency becomes frequency-dependent. This alternative model is applied to the high Tc superconductor Bi2Sr2CaCu2O8+δ (Bi2212) with Tc = 92 K, and the results are compared and contrasted with the ones obtained from the conventional extended Drude model. The results point to several advantages of this alternative approach to the extended Drude model.

Buccal Dosage Forms: General Considerations for Pediatric Patients.

PubMed

Montero-Padilla, Soledad; Velaga, Sitaram; Morales, Javier O

2017-02-01

The development of an appropriate dosage form for pediatric patients needs to take into account several aspects, since adult drug biodistribution differs from that of pediatrics. In recent years, buccal administration has become an attractive route, having different dosage forms under development including tablets, lozenges, films, and solutions among others. Furthermore, the buccal epithelium can allow quick access to systemic circulation, which could be used for a rapid onset of action. For pediatric patients, dosage forms to be placed in the oral cavity have higher requirements for palatability to increase acceptance and therapy compliance. Therefore, an understanding of the excipients required and their functions and properties needs to be particularly addressed. This review is focused on the differences and requirements relevant to buccal administration for pediatric patients (compared to adults) and how novel dosage forms can be less invasive and more acceptable alternatives.

A pluralist challenge to "integrative medicine": Feyerabend and Popper on the cognitive value of alternative medicine.

PubMed

Kidd, Ian James

2013-09-01

This paper is a critique of 'integrative medicine' as an ideal of medical progress on the grounds that it fails to realise the cognitive value of alternative medicine. After a brief account of the cognitive value of alternative medicine, I outline the form of 'integrative medicine' defended by the late Stephen Straus, former director of the US National Centre for Complementary and Alternative Medicine. Straus' account is then considered in the light of Zuzana Parusnikova's recent criticism of 'integrative medicine' and her distinction between 'cognitive' and 'opportunistic' engagement with alternative medicine. Parusnikova warns that the medical establishment is guilty of 'dogmatism' and proposes that one can usefully invoke Karl Popper's 'critical rationalism' as an antidote. Using the example of Straus, I argue that an appeal to Popper is insufficient, on the grounds that 'integrative medicine' can class as a form of cognitively-productive, critical engagement. I suggest that Parusnikova's appeal to Popper should be augmented with Paul Feyerabend's emphasis upon the role of 'radical alternatives' in maximising criticism. 'Integrative medicine' fails to maximise criticism because it 'translates' alternative medicine into the theories and terminology of allopathic medicine and so erodes its capacity to provide cognitively-valuable 'radical alternatives'. These claims are then illustrated with a discussion of 'traditional' and 'medical' acupuncture. I conclude that 'integrative medicine' fails to exploit the cognitive value of alternative medicine and so should be rejected as an ideal of medical progress. Copyright © 2013 Elsevier Ltd. All rights reserved.

Microfluidic T-form mixer utilizing switching electroosmotic flow.

PubMed

Lin, Che-Hsin; Fu, Lung-Ming; Chien, Yu-Sheng

2004-09-15

This paper presents a microfluidic T-form mixer utilizing alternatively switching electroosmotic flow. The microfluidic device is fabricated on low-cost glass slides using a simple and reliable fabrication process. A switching DC field is used to generate an electroosmotic force which simultaneously drives and mixes the fluid samples. The proposed design eliminates the requirements for moving parts within the microfluidic device and delicate external control systems. Two operation modes, namely, a conventional switching mode and a novel pinched switching mode, are presented. Computer simulation is employed to predict the mixing performance attainable in both operation modes. The simulation results are then compared to those obtained experimentally. It is shown that a mixing performance as high as 97% can be achieved within a mixing distance of 1 mm downstream from the T-junction when a 60 V/cm driving voltage and a 2-Hz switching frequency are applied in the pinched switching operation mode. This study demonstrates how the driving voltage and switching frequency can be optimized to yield an enhanced mixing performance. The novel methods presented in this study provide a simple solution to mixing problems in the micro-total-analysis-systems field.

Acoustic barriers obtained from industrial wastes.

PubMed

Garcia-Valles, M; Avila, G; Martinez, S; Terradas, R; Nogués, J M

2008-07-01

Acoustic pollution is an environmental problem that is becoming increasingly more important in our society. Likewise, the accumulation of generated waste and the need for waste management are also becoming more and more pressing. In this study we describe a new material--called PROUSO--obtained from industrial wastes. PROUSO has a variety of commercial and engineering, as well as building, applications. The main raw materials used for this environmentally friendly material come from slag from the aluminium recycling process, dust from the marble industry, foundry sands, and recycled expanded polystyrene from recycled packaging. Some natural materials, such as plastic clays, are also used. To obtain PROUSO we used a conventional ceramic process, forming new mineral phases and incorporating polluted elements into the structure. Its physical properties make PROUSO an excellent acoustic and thermal insulation material. It absorbs 95% of the sound in the frequency band of the 500 Hz. Its compressive strength makes it ideal for use in ceramic wall building.

Alternative methods for the control of postharvest citrus diseases.

PubMed

Talibi, I; Boubaker, H; Boudyach, E H; Ait Ben Aoumar, A

2014-07-01

The postharvest diseases of citrus fruit cause considerable losses during storage and transportation. These diseases are managed principally by the application of synthetic fungicides. However, the increasing concern for health hazards and environmental pollution due to chemical use has required the development of alternative strategies for the control of postharvest citrus diseases. Management of postharvest diseases using microbial antagonists, natural plant-derived products and Generally Recognized As Safe compounds has been demonstrated to be most suitable to replace the synthetic fungicides, which are either being banned or recommended for limited use. However, application of these alternatives by themselves may not always provide a commercially acceptable level of control of postharvest citrus diseases comparable to that obtained with synthetic fungicides. To provide more effective disease control, a multifaceted approach based on the combination of different postharvest treatments has been adopted. Actually, despite the distinctive features of these alternative methods, several reasons hinder the commercial use of such treatments. Consequently, research should emphasize the development of appropriate tools to effectively implement these alternative methods to commercial citrus production. © 2014 The Society for Applied Microbiology.

Cross-Validation of a Short Form of the Marlowe-Crowne Social Desirability Scale.

ERIC Educational Resources Information Center

Zook, Avery, II; Sipps, Gary J.

1985-01-01

Presents a cross-validation of Reynolds' short form of the Marlowe-Crowne Social Desirability Scale (N=233). Researchers administered 13 items as a separate entity, calculated Cronbach's Alpha for each sex, and computed test-retest correlation for one group. Concluded that the short form is a viable alternative. (Author/NRB)

In Vitro Study of Taenia solium Postoncospheral Form

PubMed Central

Chile, Nancy; Clark, Taryn; Arana, Yanina; Ortega, Ynes R.; Palma, Sandra; Mejia, Alan; Angulo, Noelia; Kosek, Jon C.; Kosek, Margaret; Gomez-Puerta, Luis A.; Garcia, Hector H.; Gavidia, Cesar M.; Gilman, Robert H.; Verastegui, Manuela

2016-01-01

Background The transitional period between the oncosphere and the cysticercus of Taenia solium is the postoncospheral (PO) form, which has not yet been completely characterized. The aim of this work was to standardize a method to obtain T. solium PO forms by in vitro cultivation. We studied the morphology of the PO form and compared the expression of antigenic proteins among the PO form, oncosphere, and cysticerci stages. Methodology/Principal Findings T. solium activated oncospheres were co-cultured with ten cell lines to obtain PO forms, which we studied at three stages of development–days 15, 30, and 60. A high percentage (32%) of PO forms was obtained using HCT-8 cells in comparison to the other cell lines. The morphology was observed by bright field, scanning, and transmission electron microscopy. Morphology of the PO form changed over time, with the six hooks commonly seen in the oncosphere stage disappearing in the PO forms, and vesicles and microtriches observed in the tegument. The PO forms grew as they aged, reaching a diameter of 2.5 mm at 60 days of culture. 15–30 day PO forms developed into mature cysticerci when inoculated into rats. Antigenic proteins expressed in the PO forms are also expressed by the oncosphere and cysticerci stages, with more cysticerci antigenic proteins expressed as the PO forms ages. Conclusions/Significance This is the first report of an in vitro production method of T. solium PO forms. The changes observed in protein expression may be useful in identifying new targets for vaccine development. In vitro culture of PO form will aid in understanding the host-parasite relationship, since the structural changes of the developing PO forms may reflect the parasite’s immunoprotective mechanisms. A wider application of this method could significantly reduce the use of animals, and thus the costs and time required for further experimental investigations. PMID:26863440

Alternative conceptions, memory, & mental models in physics education

NASA Astrophysics Data System (ADS)

Lee, Gyoungho; Shin, Jongho; Park, Jiyeon; Song, Sangho; Kim, Yeounsoo; Bao, Lei

2005-09-01

There are two somewhat independent research traditions, which converge to suggest a form of students' knowledge: alternative conceptions and mental models. However we have little literature that explains what they are different from each other and from memory. This study tried to describe these issues with some thoughts about how cognitive psychology and science education approaches can be best synthesized in order to approach these questions.

Use of alternative medicine by patients in a rural family practice clinic.

PubMed

del Mundo, Winfred F B; Shepherd, William C; Marose, Thomas D

2002-03-01

There has been an increasing awareness of the use of alternative medicine and its effect on health care in the United States. However, no previous study has looked at its use among primary care patients in a rural setting. We conducted this study to determine the patterns of use of alternative medicine in this population. A questionnaire was distributed to 750 adult patients in a family practice clinic in northern Pennsylvania. Our response rate was 88% (664/750). Forty-seven percent of patients reported using at least one form of alternative medicine during the past year The most-common types used were chiropractic (used by 17.2% of respondents), relaxation techniques (16.9%), herbal medicine (16.9%), and massage (14.2%). The patients surveyed used alternative medicine more for its benefits than because of dissatisfaction with conventional medicine. Only 51% of patients told their physician about their use of alternative medicine. A significant number of rural family practice patients are using alternative medicine. To better address their patients' needs, primary care physicians should routinely ask patients about their use of alternative medicine and advise them accordingly.

Toward a Concept of Facilitative Theorizing: An Alternative to Prescriptive and Descriptive Theory in Educational Technology

ERIC Educational Resources Information Center

Yanchar, Stephen C.; Faulconer, James E.

2011-01-01

This article presents the concept of facilitative theorizing as an alternative to prescriptive and descriptive theory in educational technology. The authors contend that these traditional forms of theory do not offer sufficient assistance to practitioners as they go about everyday design work. Facilitative theorizing, as an alternative, is…

Electrochemical and spectroscopic study on the interaction between isoprenaline and DNA using multivariate curve resolution-alternating least squares.

PubMed

Ni, Yongnian; Wei, Min; Kokot, Serge

2011-11-01

Interaction of isoprenaline (ISO) with calf-thymus DNA was studied by spectroscopic and electrochemical methods. The behavior of ISO was investigated at a glassy carbon electrode (GCE) by cyclic voltammetry (CV) and differential pulse stripping voltammetry (DPSV); ISO was oxidized and an irreversible oxidation peak was observed. The binding constant K and the stoichiometric coefficient m of ISO with DNA were evaluated. Also, with the addition of DNA, hyperchromicity of the UV-vis absorption spectra of ISO was noted, while the fluorescence intensity decreased significantly. Multivariate curve resolution-alternating least squares (MCR-ALS) chemometrics method was applied to resolve the combined spectroscopic data matrix, which was obtained by the UV-vis and fluorescence methods. Pure spectra of ISO, DNA and ISO-DNA complex, and their concentration profiles were then successfully obtained. The results indicated that the ISO molecule intercalated into the base-pairs of DNA, and the complex of ISO-DNA was formed. Copyright © 2011 Elsevier B.V. All rights reserved.

The use of alternative therapies in the Saskatchewan stroke rehabilitation population

PubMed Central

Blackmer, Jeff; Jefromova, Ludmilla

2002-01-01

Background Many patients use alternative therapies. The purpose of this study was to determine the percentage of stroke rehabilitation patients in Saskatchewan using alternative therapies, whether patients found these therapies effective in alleviating stroke-related symptoms, how often those patients who used alternative therapies discuss this fact with their primary care doctor and the main reason why patients might not do so. Methods Telephone questionnaire surveys were conducted with 117 patients who had suffered a stroke and undergone inpatient or outpatient rehabilitation at Saskatoon City Hospital. Results The study revealed that 26.5% of 117 stroke rehabilitation patients visited alternative practitioners at least once or used some form of unconventional therapy. Only 16.1% of patients found that alternative therapy made them feel much better. Of those who used alternative therapy, 61.3% did not discuss this fact with their primary physician. Many of the respondents (47.3%) who did not inform their physician stated that they did not see the necessity of talking about these treatments and 21.1% did not discuss the issue with their physician because they felt that he or she might disapprove of alternative therapies. Conclusion A relatively small percentage of stroke patients found alternative therapies beneficial. Doctors should be aware that a significant number of patients will try alternative treatment without discussion with their primary care physician or specialist. The current study suggests that after completing routine questioning, doctors should also ask their patients about their use of alternative therapies and, when appropriate, review issues of safety and efficacy. PMID:12095423

Epistemological issues in the study of microbial life: alternative terran biospheres?

PubMed

Cleland, Carol E

2007-12-01

The assumption that all life on Earth today shares the same basic molecular architecture and biochemistry is part of the paradigm of modern biology. This paper argues that there is little theoretical or empirical support for this widely held assumption. Scientists know that life could have been at least modestly different at the molecular level and it is clear that alternative molecular building blocks for life were available on the early Earth. If the emergence of life is, like other natural phenomena, highly probable given the right chemical and physical conditions then it seems likely that the early Earth hosted multiple origins of life, some of which produced chemical variations on life as we know it. While these points are often conceded, it is nevertheless maintained that any primitive alternatives to familiar life would have been eliminated long ago, either amalgamated into a single form of life through lateral gene transfer (LGT) or alternatively out-competed by our putatively more evolutionarily robust form of life. Besides, the argument continues, if such life forms still existed, we surely would have encountered telling signs of them by now. These arguments do not hold up well under close scrutiny. They reflect a host of assumptions that are grounded in our experience with large multicellular organisms and, most importantly, do not apply to microbial forms of life, which cannot be easily studied without the aid of sophisticated technologies. Significantly, the most powerful molecular biology techniques available-polymerase chain reaction (PCR) amplification of rRNA genes augmented by metagenomic analysis-could not detect such microbes if they existed. Given the profound philosophical and scientific importance that such a discovery would represent, a dedicated search for 'shadow microbes' (heretofore unrecognized 'alien' forms of terran microbial life) seems in order. The best place to start such a search is with puzzling (anomalous) phenomena, such as

A Preliminary Discussion on Several Forms of Alternate Location Schooling in Ethnic Minority Education and the Problems Therein

ERIC Educational Resources Information Center

Ba, Zhanlong

2010-01-01

"Alternate location schooling" ("yidi banxue"), a special measure adopted in China to advance ethnic minority education and especially basic education, adheres to the principle of providing focused educational support in Tibet and Xinjiang and giving consideration to education in ethnic minority regions nationwide. Since the…

[Alternative and complementary medicine from the primary care physician's viewpoint].

PubMed

Soós, Sándor Árpád; Eőry, Ajándék; Eőry, Ajándok; Harsányi, László; Kalabay, László

2015-07-12

The patients initiate the use of complementary and alternative medicine and this often remains hidden from their primary care physician. To explore general practitioners' knowledge and attitude towards complementary and alternative medicine, and study the need and appropriate forms of education, as well as ask their opinion on integration of alternative medicine into mainstream medicine. A voluntary anonymous questionnaire was used on two conferences for general practitioners organized by the Family Medicine Department of Semmelweis University. Complementary and alternative medicine was defined by the definition of the Hungarian Academy of Sciences and certified modalities were all listed. 194 general practitioners answered the questionnaire (39.8% response rate). 14% of the responders had licence in at least one of the complementary and alternative therapies, 45% used complementary and alternative therapy in their family in case of illness. It was the opinion of the majority (91.8%) that it was necessary to be familiar with every method used by their patients, however, 82.5% claimed not to have enough knowledge in complementary medicine. Graduate and postgraduate education in the field was thought to be necessary by 86% of the responders; increased odds for commitment in personal education was found among female general practitioners, less than 20 years professional experience and personal experience of alternative medicine. These data suggest that general practitioners would like to know more about complementary and alternative medicine modalities used by their patients. They consider education of medical professionals necessary and a special group is willing to undergo further education in the field.

Direct Reduction of Ferrous Oxides to form an Iron-Rich Alternative Charge Material

NASA Astrophysics Data System (ADS)

Ünal, H. İbrahim; Turgut, Enes; Atapek, Ş. H.; Alkan, Attila

2015-12-01

In this study, production of sponge iron by direct reduction of oxides and the effect of reductant on metallization were investigated. In the first stage of the study, scale formed during hot rolling of slabs was reduced in a rotating furnace using solid and gas reductants. Coal was used as solid reductant and hydrogen released from the combustion reaction of LNG was used as the gas one. The sponge iron produced by direct reduction was melted and solidified. In the second stage, Hematite ore in the form of pellets was reduced using solid carbon in a furnace heated up to 1,100°C for 60 and 120 minutes. Reduction degree of process was evaluated as a function of time and the ratio of Cfix/Fetotal. In the third stage, final products were examined using scanning electron microscope and microanalysis was carried out by energy dispersive x-ray spectrometer attached to the electron microscope. It is concluded that (i) direct reduction using both solid and gas reductants caused higher metallization compared to using only solid reductant, (ii) as the reduction time and ratio of Cfix/Fetotal increased %-reduction of ore increased.

Secondary Waste Form Down Selection Data Package – Ceramicrete

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cantrell, Kirk J.; Westsik, Joseph H.

2011-08-31

As part of high-level waste pretreatment and immobilized low activity waste processing, liquid secondary wastes will be generated that will be transferred to the Effluent Treatment Facility on the Hanford Site for further treatment. These liquid secondary wastes will be converted to stable solid waste forms that will be disposed in the Integrated Disposal Facility. Currently, four waste forms are being considered for stabilization and solidification of the liquid secondary wastes. These waste forms are Cast Stone, Ceramicrete, DuraLith, and Fluidized Bed Steam Reformer. The preferred alternative will be down selected from these four waste forms. Pacific Northwest National Laboratorymore » is developing data packages to support the down selection process. The objective of the data packages is to identify, evaluate, and summarize the existing information on the four waste forms being considered for stabilization and solidification of the liquid secondary wastes. The information included will be based on information available in the open literature and from data obtained from testing currently underway. This data package is for the Ceramicrete waste form. Ceramicrete is a relatively new engineering material developed at Argonne National Laboratory to treat radioactive and hazardous waste streams (e.g., Wagh 2004; Wagh et al. 1999a, 2003; Singh et al. 2000). This cement-like waste form can be used to treat solids, liquids, and sludges by chemical immobilization, microencapsulation, and/or macroencapsulation. The Ceramicrete technology is based on chemical reaction between phosphate anions and metal cations to form a strong, dense, durable, low porosity matrix that immobilizes hazardous and radioactive contaminants as insoluble phosphates and microencapsulates insoluble radioactive components and other constituents that do not form phosphates. Ceramicrete is a type of phosphate-bonded ceramic, which are also known as chemically bonded phosphate ceramics. The

Alternate nozzle ablative materials program

NASA Technical Reports Server (NTRS)

Kimmel, N. A.

1984-01-01

Four subscale solid rocket motor tests were conducted successfully to evaluate alternate nozzle liner, insulation, and exit cone structural overwrap components for possible application to the Space Shuttle Solid Rocket Motor (SRM) nozzle asasembly. The 10,000 lb propellant motor tests were simulated, as close as practical, the configuration and operational environment of the full scale SRM. Fifteen PAN based and three pitch based materials had no filler in the phenolic resin, four PAN based materials had carbon microballoons in the resin, and the rest of the materials had carbon powder in the resin. Three nozzle insulation materials were evaluated; an aluminum oxide silicon oxide ceramic fiber mat phenolic material with no resin filler and two E-glass fiber mat phenolic materials with no resin filler. It was concluded by MTI/WD (the fabricator and evaluator of the test nozzles) and NASA-MSFC that it was possible to design an alternate material full scale SRM nozzle assembly, which could provide an estimated 360 lb increased payload capability for Space Shuttle launches over that obtainable with the current qualified SRM design.

Alternative 2-keto acid oxidoreductase activities in Trichomonas vaginalis.

PubMed

Brown, D M; Upcroft, J A; Dodd, H N; Chen, N; Upcroft, P

1999-01-25

We have induced high levels of resistance to metronidazole (1 mM or 170 microg ml(-1)) in two different strains of Trichomonas vaginalis (BRIS/92/STDL/F1623 and BRIS/92/STDL/B7708) and have used one strain to identify two alternative T. vaginalis 2-keto acid oxidoreductases (KOR) both of which are distinct from the already characterised pyruvate:ferredoxin oxidoreductase (PFOR). Unlike the characterised PFOR which is severely down-regulated in metronidazole-resistant parasites, both of the alternative KORs are fully active in metronidazole-resistant T. vaginalis. The first, KORI, localized in all membrane fractions but predominantly in the hydrogenosome fraction, is soluble in Triton X-100 and the second, KOR2, is extractable in 1 M acetate from membrane fractions of metronidazole-resistant parasites. PFOR and both KORI and KOR2 use a broad range of 2-keto acids as substrates (pyruvate, alpha-ketobutyrate, alpha-ketomalonate), including the deaminated forms of aromatic amino acids (indolepyruvate and phenylpyruvate). However, unlike PFOR neither KORI or KOR2 was able to use oz-ketoglutarate. Deaminated forms of branched chain amino acids (alpha-ketoisovalerate) were not substrates for T. vaginalis KORs. Since KOR I and KOR2 do not apparently donate electrons to ferredoxin, and are not down-regulated in metronidazole-resistant parasites, we propose that KORI and KOR2 provide metronidazole-resistant parasites with an alternative energy production pathway(s) which circumvents metronidazole activation.

Status of plutonium ceramic immobilization processes and immobilization forms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ebbinghaus, B.B.; Van Konynenburg, R.A.; Vance, E.R.

1996-05-01

Immobilization in a ceramic followed by permanent emplacement in a repository or borehole is one of the alternatives currently being considered by the Fissile Materials Disposition Program for the ultimate disposal of excess weapons-grade plutonium. To make Pu recovery more difficult, radioactive cesium may also be incorporated into the immobilization form. Valuable data are already available for ceramics form R&D efforts to immobilize high-level and mixed wastes. Ceramics have a high capacity for actinides, cesium, and some neutron absorbers. A unique characteristic of ceramics is the existence of mineral analogues found in nature that have demonstrated actinide immobilization over geologicmore » time periods. The ceramic form currently being considered for plutonium disposition is a synthetic rock (SYNROC) material composed primarily of zirconolite (CaZrTi{sub 2}O{sub 7}), the desired actinide host phase, with lesser amounts of hollandite (BaAl{sub 2}Ti{sub 6}O{sub 16}) and rutile (TiO{sub 2}). Alternative actinide host phases are also being considered. These include pyrochlore (Gd{sub 2}Ti{sub 2}O{sub 7}), zircon (ZrSiO{sub 4}), and monazite (CePO{sub 4}), to name a few of the most promising. R&D activities to address important technical issues are discussed. Primarily these include moderate scale hot press fabrications with plutonium, direct loading of PuO{sub 2} powder, cold press and sinter fabrication methods, and immobilization form formulation issues.« less

17 CFR 301.0-1 - Availability of forms.

Code of Federal Regulations, 2010 CFR

2010-04-01

... A to Part 285 FORMS, SECURITIES INVESTOR PROTECTION CORPORATION § 301.0-1 Availability of forms. The forms prescribed for use under the Securities Investor Protection Act of 1970, as amended, (the “Act... may be obtained upon request to, as appropriate, the Securities Investor Protection Corporation (“SIPC...

48 CFR 908.7115 - Forms.

Code of Federal Regulations, 2014 CFR

2014-10-01

... be obtained by DOE offices in accordance with the DOE Guide 242.1-1, DOE Forms Management, for use with DOE Order 200.1, Information Management Program. (b) Standard, optional, and certain other agency...

48 CFR 908.7115 - Forms.

Code of Federal Regulations, 2012 CFR

2012-10-01

... be obtained by DOE offices in accordance with the DOE Guide 242.1-1, DOE Forms Management, for use with DOE Order 200.1, Information Management Program. (b) Standard, optional, and certain other agency...

48 CFR 908.7115 - Forms.

Code of Federal Regulations, 2013 CFR

2013-10-01

... be obtained by DOE offices in accordance with the DOE Guide 242.1-1, DOE Forms Management, for use with DOE Order 200.1, Information Management Program. (b) Standard, optional, and certain other agency...

48 CFR 908.7115 - Forms.

Code of Federal Regulations, 2011 CFR

2011-10-01

... be obtained by DOE offices in accordance with the DOE Guide 242.1-1, DOE Forms Management, for use with DOE Order 200.1, Information Management Program. (b) Standard, optional, and certain other agency...

48 CFR 908.7115 - Forms.

Code of Federal Regulations, 2010 CFR

2010-10-01

... be obtained by DOE offices in accordance with the DOE Guide 242.1-1, DOE Forms Management, for use with DOE Order 200.1, Information Management Program. (b) Standard, optional, and certain other agency...

Magnetostrictive Alternator

NASA Technical Reports Server (NTRS)

Bruder, Geoffrey A. (Inventor); Dyson, Jr., Rodger W. (Inventor)

2018-01-01

A magnetostrictive alternator configured to convert pressure waves into electrical energy is provided. It should be appreciated that the magnetostrictive alternator may be combined in some embodiments with a Stirling engine to produce electrical power. The Stirling engine creates the oscillating pressure wave and the magnetostrictive alternator converts the pressure wave into electricity. In some embodiments, the magnetostrictive alternator may include aerogel material and magnetostrictive material. The aerogel material may be configured to convert a higher amplitude pressure wave into a lower amplitude pressure wave. The magnetostrictive material may be configured to generate an oscillating magnetic field when the magnetostrictive material is compressed by the lower amplitude pressure wave.

46 CFR 169.205 - Obtaining or renewing a Certificate of Inspection.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SAILING SCHOOL VESSELS Inspection and Certification Certificate of Inspection § 169.205 Obtaining or... for inspection on Form CG-3752; and (2) Evidence that the vessel has been designated as a sailing...

46 CFR 169.205 - Obtaining or renewing a Certificate of Inspection.

Code of Federal Regulations, 2011 CFR

2011-10-01

... SAILING SCHOOL VESSELS Inspection and Certification Certificate of Inspection § 169.205 Obtaining or... for inspection on Form CG-3752; and (2) Evidence that the vessel has been designated as a sailing...

Forum: Interpersonal Communication in Instructional Settings. The Instructor-Student Relationship as an Alternative Form of Superior-Subordinate Relationship

ERIC Educational Resources Information Center

Myers, Scott A.

2017-01-01

In this brief forum article, the author suggests studying the instructor-student relationship as a superior-subordinate relationship offers an alternative way to view how student learning occurs in the college classroom, and can provide instructional communication researchers with the opportunity to explore how structural and institutional…

Globally Deghosting for Marine Streamer with Alternating Minimization Approach in Frequency-slowness Domain

NASA Astrophysics Data System (ADS)

Wang, C.; Zhu, Z.; Gu, H.; Liu, C.; Liu, Z.; Jiao, Z.

2017-12-01

The ghost effects of the sea surface can generate notch in marine towed-streamer data, which results in narrow bandwidth of seismic data. Currently, deghosting is widely utilized to increase the bandwidth of the seismic data or the images. However, most of the conventional deghosting algorithms havenot considered the error of streamer depth causing a biased ghost-delay time (τ) with respect to primary reflection and amplitude difference coefficient (r) between ghost and primary reflection varies with offset due to rugged seabed and target depth variation. We proposed a ghost filtering operator considering the protentional biases within the ghost-delay time (τ) and the amplitude difference coefficient (r). The up-going wavefield (u), ghost-delay time (τ) and amplitude difference coefficient (r) can be obtained by utilizing alternating minimization approach for minimizing the difference between actual wavefield and theoretical wavefield in frequency-slowness domain. The main idea is to alternatively updating u, τ and r in each iteration: we update u by least-squares when we keep τ and r constant; and we then keep u constant and optimize over τ and r with a closed-form solution which is closely related to matched filtering. The convergence of the proposed algorithm is guaranteed since we have closed-form solutions for each stage. The experiments on synthetic record confirmed the reliability of the proposed algorithm. We also demonstrate our proposed method in marine VDS shot acquisition. After migration stack processing, our ghosting method significantly increases the bandwidth of the average amplitude, amplitude energy of the medium and high frequency spectrum, improving resolution of medium and deep reflection and providing higher signal-to-noise ratio with clear break point. This research is funded by China Important National Science & Technology Specific Projects (2016ZX05026001-001).

Nanogrids and Beehive-Like Nanostructures Formed by Plasma Etching the Self-Organized SiGe Islands

NASA Astrophysics Data System (ADS)

Chang, Yuan-Ming; Jian, Sheng-Rui; Juang, Jenh-Yih

2010-09-01

A lithography-free method for fabricating the nanogrids and quasi-beehive nanostructures on Si substrates is developed. It combines sequential treatments of thermal annealing with reactive ion etching (RIE) on SiGe thin films grown on (100)-Si substrates. The SiGe thin films deposited by ultrahigh vacuum chemical vapor deposition form self-assembled nanoislands via the strain-induced surface roughening (Asaro-Tiller-Grinfeld instability) during thermal annealing, which, in turn, serve as patterned sacrifice regions for subsequent RIE process carried out for fabricating nanogrids and beehive-like nanostructures on Si substrates. The scanning electron microscopy and atomic force microscopy observations confirmed that the resultant pattern of the obtained structures can be manipulated by tuning the treatment conditions, suggesting an interesting alternative route of producing self-organized nanostructures.

Identification of vacuoles containing extraintestinal differentiated forms of Legionella pneumophila in colonized Caenorhabditis elegans soil nematodes.

PubMed

Hellinga, Jacqueline R; Garduño, Rafael A; Kormish, Jay D; Tanner, Jennifer R; Khan, Deirdre; Buchko, Kristyn; Jimenez, Celine; Pinette, Mathieu M; Brassinga, Ann Karen C

2015-08-01

Legionella pneumophila, a causative agent of Legionnaires' disease, is a facultative intracellular parasite of freshwater protozoa. Legionella pneumophila features a unique developmental network that involves several developmental forms including the infectious cyst forms. Reservoirs of L. pneumophila include natural and man-made freshwater systems; however, recent studies have shown that isolates of L. pneumophila can also be obtained directly from garden potting soil suggesting the presence of an additional reservoir. A previous study employing the metazoan Caenorhabditis elegans, a member of the Rhabditidae family of free-living soil nematodes, demonstrated that the intestinal lumen can be colonized with L. pneumophila. While both replicative forms and differentiated forms were observed in C. elegans, these morphologically distinct forms were initially observed to be restricted to the intestinal lumen. Using live DIC imaging coupled with focused transmission electron microscopy analyses, we report here that L. pneumophila is able to invade and establish Legionella-containing vacuoles (LCVs) in the intestinal cells. In addition, LCVs containing replicative and differentiated cyst forms were observed in the pseudocoelomic cavity and gonadal tissue of nematodes colonized with L. pneumophila. Furthermore, establishment of LCVs in the gonadal tissue was Dot/Icm dependent and required the presence of the endocytic factor RME-1 to gain access to maturing oocytes. Our findings are novel as this is the first report, to our knowledge, of extraintestinal LCVs containing L. pneumophila cyst forms in C. elegans tissues, highlighting the potential of soil-dwelling nematodes as an alternate environmental reservoir for L. pneumophila. © 2015 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd.

Development and evaluation of short forms of the Pain Catastrophizing Scale and the Pain Self-efficacy Questionnaire.

PubMed

McWilliams, L A; Kowal, J; Wilson, K G

2015-10-01

To facilitate efficient screening and reduce the length of comprehensive self-report batteries, a four-item short form of the Pain Catastrophizing Scale (PCS) and a two-item short form of the Pain Self-Efficacy Questionnaire (PSEQ) have been developed and evaluated in samples of patients with arm and upper extremity pain. The first aim of this study was to evaluate these short forms in a heterogeneous sample of patients seeking treatment for chronic musculoskeletal pain, using a priori criteria for determining adequate internal consistency, construct validity and sensitivity to change. In addition, the findings of past studies were used to identify items suitable for new and potentially stronger short forms of these measures. Data were provided by 280 patients who completed the original PCS and PSEQ as part of an interdisciplinary rehabilitation programme. The previously developed four-item PCS and the newly developed six-item short form of the PCS both met the internal consistency and construct validity criteria. They did not meet the criterion regarding sensitivity to change. However, similar to what was obtained using the original PCS, large effect sizes were found when using these short forms to examine pre-treatment to post-treatment changes in catastrophizing. For the PSEQ, the new four-item short form was clearly superior to the other alternatives and met all three criteria. The strongest short forms of the PCS and PSEQ could facilitate the assessment of pain catastrophizing and self-efficacy in situations in which the use of the longer original measures is not feasible. © 2015 European Pain Federation - EFIC®

A clinical study to evaluate the correlation between maxillary central incisor tooth form and face form in an Indian population.

PubMed

Koralakunte, Pavankumar R; Budihal, Dhanyakumar H

2012-09-01

A study was performed to examine the correlation between maxillary central incisor tooth form and face form in males and females in an Indian population. The selection of prosthetic teeth for edentulous patients is a primary issue in denture esthetics, especially in the case of maxillary central incisors, which are the most prominent teeth in the arch. Two hundred dental students of Indian origin comprising 79 males and 121 females aged 18-28 years studying at Bapuji Dental College and Hospital were randomly selected as the study subjects. A standardized photographic procedure was used to obtain images of the face and the maxillary central incisors. The outline forms of the face and the maxillary right central incisor tooth were determined using a standardized method. The outline forms obtained were used to classify both face form and tooth form on the basis of visual and William's methods. The means were considered after evaluation by five prosthodontists, and the results were tabulated. Statistical analysis was performed using the chi-squared test for association and Z-test for equality of proportions. A correlation greater than 50% was observed between tooth form and face form by the visual method, compared with one of 31.5% by William's method. There was no highly defined correlation between maxillary central incisor tooth form and face form among the male and female Indian subjects studied.

Alternative approaches to epilepsy treatment.

PubMed

McElroy-Cox, Caitlin

2009-07-01

Complementary and alternative medicine (CAM) is a diverse group of health care practices and products that fall outside the realm of traditional Western medical theory and practice and that are used to complement or replace conventional medical therapies. The use of CAM has increased over the past two decades, and surveys have shown that up to 44% of patients with epilepsy are using some form of CAM treatment. This article reviews the CAM modalities of meditation, yoga, relaxation techniques, biofeedback, nutritional and herbal supplements, dietary measures, chiropractic care, acupuncture, Reiki, and homeopathy and what is known about their potential efficacy in patients with epilepsy.

42 CFR 50.205 - Consent form requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... APPLICABILITY Sterilization of Persons in Federally Assisted Family Planning Projects § 50.205 Consent form... person who obtains the consent; and (4) The physician who will perform the sterilization procedure. (c... performing the sterilization must certify by signing the consent form, that: (i) Shortly before the...

An experimental description of the flow in a centrifugal compressor from alternate stall to surge

NASA Astrophysics Data System (ADS)

Moënne-Loccoz, V.; Trébinjac, I.; Benichou, E.; Goguey, S.; Paoletti, B.; Laucher, P.

2017-08-01

The present paper gives the experimental results obtained in a centrifugal compressor stage designed and built by SAFRAN Helicopter Engines. The compressor is composed of inlet guide vanes, a backswept splittered unshrouded impeller, a splittered vaned radial diffuser and axial outlet guide vanes. Previous numerical simulations revealed a particular S-shape pressure rise characteristic at partial rotation speed and predicted an alternate flow pattern in the vaned radial diffuser at low mass flow rate. This alternate flow pattern involves two adjacent vane passages. One passage exhibits very low momentum and a low pressure recovery, whereas the adjacent passage has very high momentum in the passage inlet and diffuses efficiently. Experimental measurements confirm the S-shape of the pressure rise characteristic even if the stability limit experimentally occurs at higher mass flow than numerically predicted. At low mass flow the alternate stall pattern is confirmed thanks to the data obtained by high-frequency pressure sensors. As the compressor is throttled the path to instability has been registered and a first scenario of the surge inception is given. The compressor first experiences a steady alternate stall in the diffuser. As the mass flow decreases, the alternate stall amplifies and triggers the mild surge in the vaned diffuser. An unsteady behavior results from the interaction of the alternate stall and the mild surge. Finally, when the pressure gradient becomes too strong, the alternate stall blows away and the compressor enters into deep surge.

Screening paediatric rectal forms of azithromycin as an alternative to oral or injectable treatment.

PubMed

Kauss, Tina; Gaudin, Karen; Gaubert, Alexandra; Ba, Boubakar; Tagliaferri, Serena; Fawaz, Fawaz; Fabre, Jean-Louis; Boiron, Jean-Michel; Lafarge, Xavier; White, Nicholas J; Olliaro, Piero L; Millet, Pascal

2012-10-15

The aim of this study was to identify a candidate formulation for further development of a home or near-home administrable paediatric rectal form of a broad-spectrum antibiotic - specially intended for (emergency) use in tropical rural settings, in particular for children who cannot take medications orally and far from health facilities where injectable treatments can be given. Azithromycin, a broad-spectrum macrolide used orally or intravenously for the treatment of respiratory tract, skin and soft tissue infections, was selected because of its pharmacokinetic and therapeutic properties. Azithromycin in vitro solubility and stability in physiologically relevant conditions were studied. Various pharmaceutical forms, i.e. rectal suspension, two different rectal gels, polyethylene glycol (PEG) suppository and hard gelatin capsule (HGC) were assessed for in vitro dissolution and in vivo bioavailability in the rabbit. Azithromycin PEG suppository appears to be a promising candidate. Copyright © 2012 Elsevier B.V. All rights reserved.

Screening paediatric rectal forms of azithromycin as an alternative to oral or injectable treatment

PubMed Central

Kauss, Tina; Gaudin, Karen; Gaubert, Alexandra; Ba, Boubakar; Tagliaferri, Serena; Fawaz, Fawaz; Fabre, Jean-Louis; Boiron, Jean-Michel; Lafarge, Xavier; White, Nicholas J.; Olliaro, Piero L.; Millet, Pascal

2012-01-01

The aim of this study was to identify a candidate formulation for further development of a home or near-home administrable paediatric rectal form of a broad-spectrum antibiotic – specially intended for (emergency) use in tropical rural settings, in particular for children who cannot take medications orally and far from health facilities where injectable treatments can be given. Azithromycin, a broad-spectrum macrolide used orally or intravenously for the treatment of respiratory tract, skin and soft tissue infections, was selected because of its pharmacokinetic and therapeutic properties. Azithromycin in vitro solubility and stability in physiologically relevant conditions were studied. Various pharmaceutical forms, i.e. rectal suspension, two different rectal gels, polyethylene glycol (PEG) suppository and hard gelatin capsule (HGC) were assessed for in vitro dissolution and in vivo bioavailability in the rabbit. Azithromycin PEG suppository appears to be a promising candidate. PMID:22868232

Alternative sweeteners influence the biomass of oral biofilm.

PubMed

Abdul Razak, Fathilah; Baharuddin, Baizatul Amirah; Akbar, Elisya Farha Mohd; Norizan, Amira Hanim; Ibrahim, Nur Fazilah; Musa, Md Yusoff

2017-08-01

Compact-structured oral biofilm accumulates acids that upon prolonged exposure to tooth surface, causes demineralisation of enamel. This study aimed to assess the effect of alternative sweeteners Equal Stevia ® , Tropicana Slim ® , Pal Sweet ® and xylitol on the matrix-forming activity of plaque biofilm at both the early and established stages of formation. Saliva-coated glass beads (sGB) were used as substratum for the adhesion of a mixed-bacterial suspension of Streptococcus mutans, Streptococcus sanguinis and Streptococcus mitis. Biofilms formed on sGB at 3h and 24h represented the early and established-plaque models. The biofilms were exposed to three doses of the sweeteners (10%), introduced at three intervals to simulate the exposure of dental plaque to sugar during three consecutive food intakes. The treated sGB were (i) examined under the SEM and (ii) collected for turbidity reading. The absorbance indicated the amount of plaque mass produced. Analysis was performed comparative to sucrose as control. Higher rate of bacterial adherence was determined during the early compared to established phases of formation. Comparative to the sweeteners, sucrose showed a 40% increase in bacterial adherence and produced 70% more plaque-mass. Bacterial counts and SEM micrographs exhibited absence of matrix in all the sweetener-treated biofilms at the early phase of formation. At the established phase, presence of matrix was detected but at significantly lower degree compared to sucrose (p<0.05). Alternatives sweeteners promoted the formation of oral biofilm with lighter mass and lower bacterial adherence. Hence, suggesting alternative sweeteners as potential antiplaque agents. Copyright © 2017 Elsevier Ltd. All rights reserved.

Transparency ethics in practice: Revisiting financial conflicts of interest disclosure forms in clinical practice guidelines

PubMed Central

Sharara, Nour; Kaltenbach, Tonya; Laine, Loren; McQuaid, Kenneth; Soetikno, Roy; Subramanian, Venkataraman

2017-01-01

Background Authors of clinical practice guidelines (CPGs) disclose financial conflicts of interest (FCOIs) to promote transparency ethics. Typically, they do so on standard declaration forms containing generic open-ended questions on FCOIs. Yet, the literature is scant on the format and effect of alternative disclosure forms. Does supplementing a standard form with subsequent detailed disclosure forms tailored to the context of the CPG improve the yield or accuracy of FCOIs declarations? Methods For an international CPG in gastroenterology on the endoscopic surveillance for colorectal neoplasia in inflammatory bowel disease, we compared the use of a standard FCOIs disclosure form with a contextual FCOIs disclosure form that detailed commercial relations related to the CPG topic. This included manufacturers of endoscopes, endoscopy equipment and accessories. Participants completed the generic form early, and the supplementary contextual form six months later. We then compared the FCOI disclosures obtained. Findings 26 participants provided FCOIs disclosures using both disclosure forms. We found discrepancies regarding (1) the disclosure of FCOIs (presence/absence), and (2) the listing of financial entities. While the number of participants who disclosed a FCOI remained the same (30.8%) using the two forms, disclosures were not from the same individuals: two additional participants disclosed a FCOI, whereas two participants withdrew previous disclosures. Among those who reported a FCOI in either form, we noted inconsistencies in disclosures for 70% of the participants. This included changes in FCOIs disclosure status or modifications of "their commercial relations". Discussion Accurate reporting of FCOIs advances the transparency and ethical integrity of CPGs. Our experience suggests that a contextual FCOIs disclosure form tailored to content of the CPG with narrow, detailed questions provides supplementary, more complete FCOIs declarations than generic forms alone

NEW DISINFECTION BY-PRODUCT ISSUES: EMERGING DBP'S AND ALTERNATIVE ROUTES OF EXPOSURE

EPA Science Inventory

This paper discusses current issues with drinking water disinfection by-products (DBPs), which include emerging (unregulated) DBPs that can be formed at greater levels with alternative disinfectants (as compared to chlorine) and routes of human exposure (which include inhalation ...

Child-Headed Households: A Feasible Way Forward, or an Infringement of Children's Right to Alternative Care?

ERIC Educational Resources Information Center

Phillips, Charlotte

2011-01-01

In the face of growing international support for recognition of child-headed households, the author poses the following questions: What does the internationally recognised right to alternative care for children entail? Is the recognition of child-headed households as a form of alternative care in line with the Convention on the Rights of the Child…

Alternative School Revenue Sources: There Are Many Fish in the Sea.

ERIC Educational Resources Information Center

Pijanowski, John C.; Monk, David H.

1996-01-01

To ease fiscal strain, many school districts employ alternative fund-raising initiatives. They are forming local foundations or booster clubs, soliciting businesses or volunteers for in-kind donations, selling and leasing services and facilities, generating investment income, collecting user fees, cooperating with social service providers,…

The predictive information obtained by testing multiple software versions

NASA Technical Reports Server (NTRS)

Lee, Larry D.

1987-01-01

Multiversion programming is a redundancy approach to developing highly reliable software. In applications of this method, two or more versions of a program are developed independently by different programmers and the versions are combined to form a redundant system. One variation of this approach consists of developing a set of n program versions and testing the versions to predict the failure probability of a particular program or a system formed from a subset of the programs. The precision that might be obtained, and also the effect of programmer variability if predictions are made over repetitions of the process of generating different program versions, are examined.

Quaternary ammonium compounds: an alternative disinfection method for fresh produce wash water.

PubMed

Chaidez, Cristobal; Lopez, Javier; Castro-del Campo, Nohelia

2007-06-01

Irrigation water can serve as a vehicle for transporting pathogenic microorganisms, and numerous cases of bacterial infections from consumption of irrigated fresh produce have been reported in recent years. Chlorine-based disinfectants applied when produce is packed are widely used to control microorganisms. When applied properly, the chlorine products are effective. However, hazardous disinfection breakdown products can be formed, and chlorine disinfectants have high oxidant activity that can affect produce quality and pose a risk to food handlers. Quaternary Ammonium Compounds (QACs) are a disinfectant alternative for the washing of fruits and vegetables. They can control a great number of microorganisms, have low toxicity when used at recommended doses, and are stable in storage. The purpose of this work was to assess the disinfectant activity of QACs against Escherichia coli and Staphylococcus aureus under worst-case and average-case turbidity conditions, (2 and 100 nephelometric units); two disinfectant concentrations (100 and 200 mg/L; and two contact times (30 and 120 seconds). Our research showed that QACs were effective against both bacteria. The percentage reduction of Escherichia coli was significantly higher in the less turbid solution (P = 0.027), while turbidity did not affect the reduction of Staphylococcus aureus (P > 0.05). E. coli was more resistant to QAC treatment than S. aureus. Based on the data obtained we can conclude that QACs could be an alternative in washing processes of fruits and vegetables.

Directionally Interacting Spheres and Rods Form Ordered Phases

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Wenyan; Mahynski, Nathan A.; Gang, Oleg

The structures formed by mixtures of dissimilarly shaped nanoscale objects can significantly enhance our ability to produce nanoscale architectures. However, understanding their formation is a complex problem due to the interplay of geometric effects (entropy) and energetic interactions at the nanoscale. Spheres and rods are perhaps the most basic geometrical shapes and serve as convenient models of such dissimilar objects. The ordered phases formed by each of these individual shapes have already been explored, but, when mixed, spheres and rods have demonstrated only limited structural organization to date. We show using experiments and theory that the introduction of directional attractionsmore » between rod ends and isotropically interacting spherical nanoparticles (NPs) through DNA base pairing leads to the formation of ordered three-dimensional lattices. The spheres and rods arrange themselves in a complex alternating manner, where the spheres can form either a face-centered cubic (FCC) or hexagonal close-packed (HCP) lattice, or a disordered phase, as observed by in situ X-ray scattering. Increasing NP diameter at fixed rod length yields an initial transition from a disordered phase to the HCP crystal, energetically stabilized by rod-rod attraction across alternating crystal layers, as revealed by theory. In the limit of large NPs, the FCC structure is instead stabilized over the HCP by rod entropy. Thus, we propose that directionally specific attractions in mixtures of anisotropic and isotropic objects offer insight into unexplored self-assembly behavior of noncomplementary shaped particles.« less

Directionally Interacting Spheres and Rods Form Ordered Phases

DOE PAGES

Liu, Wenyan; Mahynski, Nathan A.; Gang, Oleg; ...

2017-05-10

The structures formed by mixtures of dissimilarly shaped nanoscale objects can significantly enhance our ability to produce nanoscale architectures. However, understanding their formation is a complex problem due to the interplay of geometric effects (entropy) and energetic interactions at the nanoscale. Spheres and rods are perhaps the most basic geometrical shapes and serve as convenient models of such dissimilar objects. The ordered phases formed by each of these individual shapes have already been explored, but, when mixed, spheres and rods have demonstrated only limited structural organization to date. We show using experiments and theory that the introduction of directional attractionsmore » between rod ends and isotropically interacting spherical nanoparticles (NPs) through DNA base pairing leads to the formation of ordered three-dimensional lattices. The spheres and rods arrange themselves in a complex alternating manner, where the spheres can form either a face-centered cubic (FCC) or hexagonal close-packed (HCP) lattice, or a disordered phase, as observed by in situ X-ray scattering. Increasing NP diameter at fixed rod length yields an initial transition from a disordered phase to the HCP crystal, energetically stabilized by rod-rod attraction across alternating crystal layers, as revealed by theory. In the limit of large NPs, the FCC structure is instead stabilized over the HCP by rod entropy. Thus, we propose that directionally specific attractions in mixtures of anisotropic and isotropic objects offer insight into unexplored self-assembly behavior of noncomplementary shaped particles.« less

The search for alternative aqueous film forming foams (AFFF) with a low environmental impact: physiological and transcriptomic effects of two Forafac(®) fluorosurfactants in turbot.

PubMed

Hagenaars, A; Meyer, I J; Herzke, D; Pardo, B G; Martinez, P; Pabon, M; De Coen, W; Knapen, D

2011-08-01

Fluorosurfactants are the key components in aqueous film forming foams (AFFF). They provide these fire fighting agents with the required low surface tension and they enable film formation on top of lighter fuels to prevent burn back. Development of effective and environmentally acceptable PFOS alternatives is one of the most important priorities in the fire fighting foam industry. DuPont™ offers the fluorosurfactant mixtures Forafac(®)1157 and Forafac(®)1157N for the formulation of AFFFs which are alternatives to the persistent and toxic perfluorooctane sulphonate (PFOS). Ecotoxicological testing of these inadequately documented mixtures is necessary to include them in AFFF hazard and risk assessment. Juvenile turbot (Scophthalmus maximus) were exposed for 14 days to 0.1; 0.5 and 1.5mg/L of the fluorosurfactant mixtures used in Forafac(®)1157 and Forafac(®)1157N. In an initial transcriptomics experiment, microarray analysis revealed differentially expressed transcripts of genes which were mainly involved in digestion and in the immune system. This discovery-driven screening approach offered the basis for new hypotheses that were tested in two subsequent experiments in which food intake, energy reserves, growth and a set of haematological parameters were examined. Additionally, effects of the two mixtures were compared to those of PFOS. Based on the results of this study, the mode of action of Forafac(®)1157N was the activation of the acute phase reaction resulting in increased leukocyte concentrations and the inhibition of growth due to the high energetic cost of toxicant exposure. For Forafac(®)1157, evidences of immunosuppression were found on the transcriptional level and the altered differential leukocyte profiles indicated that stress was induced in these fish. However, food intake, energy reserves and growth were not compromised, even at high exposure concentrations, which was in contrast to the effects seen after PFOS exposure. Taking into account

An Alternative Surgical Method for Treatment of Osteoid Osteoma

PubMed Central

Gökalp, Mehmet Ata; Gözen, Abdurrahim; Ünsal, Seyyid Şerif; Önder, Haci; Güner, Savaş

2016-01-01

Background An osteoid osteoma is a benign bone tumor that tends to be <1 cm in size. The tumor is characterized by night-time pain that may be relieved by aspirin or other non-steroidal anti-inflammatory drugs. Osteoid osteoma can be treated with various conservative and surgical methods, but these have some risks and difficulties. The purpose of the present study was to present an alternative treatment method for osteoid osteoma and the results we obtained. Material/Methods In the period from 2010 to 2014, 10 patients with osteoid osteoma underwent nidus excision by using a safe alternative method in an operating room (OR) with no computed tomography (CT). The localization of the tumor was determined by use of a CT-guided Kirschner wire in the radiology unit, then, in the OR the surgical intervention was performed without removing the Kirschner wire. Results Following the alternative intervention, all the patients were completely relieved of pain. In the follow-up, no recurrence or complication occurred. Conclusions The presented alternative method for treating osteoid osteoma is an efficient and practical procedure for surgeons working in clinics that lack specialized equipment. PMID:26898923

Ceratonia siliqua L. hydroethanolic extract obtained by ultrasonication: antioxidant activity, phenolic compounds profile and effects in yogurts functionalized with their free and microencapsulated forms.

PubMed

Rached, Irada; Barros, Lillian; Fernandes, Isabel P; Santos-Buelga, Celestino; Rodrigues, Alírio E; Ferchichi, Ali; Barreiro, Maria Filomena; Ferreira, Isabel C F R

2016-03-01

Bioactive extracts were obtained from powdered carob pulp through an ultrasound extraction process and then evaluated in terms of antioxidant activity. Ten minutes of ultrasonication at 375 Hz were the optimal conditions leading to an extract with the highest antioxidant effects. After its chemical characterization, which revealed the preponderance of gallotannins, the extract (free and microencapsulated) was incorporated in yogurts. The microspheres were prepared using an extract/sodium alginate ratio of 100/400 (mg mg(-1)) selected after testing different ratios. The yogurts with the free extract exhibited higher antioxidant activity than the samples added with the encapsulated extracts, showing the preserving role of alginate as a coating material. None of the forms significantly altered the yogurt's nutritional value. This study confirmed the efficiency of microencapsulation to stabilize functional ingredients in food matrices maintaining almost the structural integrity of polyphenols extracted from carob pulp and furthermore improving the antioxidant potency of the final product.

Alternative Fuels

EPA Pesticide Factsheets

Alternative fuels include gaseous fuels such as hydrogen, natural gas, and propane; alcohols such as ethanol, methanol, and butanol; vegetable and waste-derived oils; and electricity. Overview of alternative fuels is here.

Alternatives to Using Masculine Pronouns When Referring to the Species.

ERIC Educational Resources Information Center

Halon-Soto, Debbie; And Others

This paper reviews three studies designed to assess the impact of gender-related terms. The first study examined 144 male and female undergraduate students' preferences for and performance on tasks using alternatives to the standard English forms, "his/hers" and "him/her." The second study attempted to replicate the original study and to prove…

The use of alternative medicine by children.

PubMed

Spigelblatt, L; Laîné-Ammara, G; Pless, I B; Guyver, A

1994-12-01

Alternative medicine (AM) is of growing interest to the general public. Although several studies have been published concerning its use in adults, the use by children is less well known. The purpose of this study is to determine the frequency with which alternative medicine is employed in a pediatric population that also uses conventional medicine. A second goal is to investigate the sociodemographic factors that influence the choice of these forms of therapy. Parents of children consulting the general outpatient clinic of a university hospital completed a self-administered questionnaire asking about previous use of AM for themselves or their children. Based on 1911 completed questionnaires, 208 children (11%) previously consulted one or more AM practitioners. Chiropractic, homeopathy, naturopathy, and acupuncture together accounted for 84% of use. Children who used AM differed significantly from those who only used conventional medicine in that they were older than the nonusers, their mothers were better educated, and their parents also tended to use AM. The findings indicate that AM is an aspect of child health care that no longer can be ignored. Being aware of these practices will enable physicians to discuss alternative therapies with parents in order to ensure the continuity of essential conventional treatments.

Harmonisation of animal testing alternatives in China.

PubMed

Cheng, Shujun; Qu, Xiaoting; Qin, Yao

2017-12-01

More and more countries are lining up to follow the EU's approach and implement a full ban on the sale of cosmetics that have been tested on animals, which has been the case in the EU since 2013. Besides animal welfare considerations, the need for mutual acceptance of data (MAD) and harmonisation of the global market have made the move toward non-animal testing a desirable general trend for countries worldwide. Over the last 10 years, the concept of alternative methods has been gradually developing in China. This has seen the harmonisation of relevant legislation, the organisation of various theoretical and hands-on training sessions, the exploration of method validation, the adoption of internationally recognised methods, the propagation of alternative testing standards, and an in-depth investigation into the potential use of in vitro methods in the biosciences. There are barriers to this progress, including the demand for a completely new infrastructure, the need to build technology capability, the requirement for a national standardisation system formed through international co-operation, and the lack of technical assistance to facilitate self-innovation. China is now increasing speed in harmonising its approach to the use of non-animal alternatives, accelerating technological development and attempting to incorporate non-animal, in vitro, testing methods into the national regulatory system.

Description of the Prometheus Program Alternator/Thruster Integration Laboratory (ATIL)

NASA Technical Reports Server (NTRS)

Baez, Anastacio N.; Birchenough, Arthur G.; Lebron-Velilla, Ramon C.; Gonzalez, Marcelo C.

2005-01-01

The Project Prometheus Alternator Electric Thruster Integration Laboratory's (ATIL) primary two objectives are to obtain test data to influence the power conversion and electric propulsion systems design, and to assist in developing the primary power quality specifications prior to system Preliminary Design Review (PDR). ATIL is being developed in stages or configurations of increasing fidelity and complexity in order to support the various phases of the Prometheus program. ATIL provides a timely insight of the electrical interactions between a representative Permanent Magnet Generator, its associated control schemes, realistic electric system loads, and an operating electric propulsion thruster. The ATIL main elements are an electrically driven 100 kWe Alternator Test Unit (ATU), an alternator controller using parasitic loads, and a thruster Power Processing Unit (PPU) breadboard. This paper describes the ATIL components, its development approach, preliminary integration test results, and current status.

40 CFR 721.30 - EPA approval of alternative control measures.

Code of Federal Regulations, 2013 CFR

2013-07-01

...), must submit the request to EPA via EPA's Central Data Exchange (CDX) using EPA-provided e-PMN software... obtain e-PMN software. Support documents related to these requests must be submitted in the manner set... involved. (5) The specifications of the alternative worker exposure control measures or environmental...

40 CFR 721.30 - EPA approval of alternative control measures.

Code of Federal Regulations, 2011 CFR

2011-07-01

...), must submit the request to EPA via EPA's Central Data Exchange (CDX) using EPA-provided e-PMN software... obtain e-PMN software. Support documents related to these requests must be submitted in the manner set... involved. (5) The specifications of the alternative worker exposure control measures or environmental...

40 CFR 721.30 - EPA approval of alternative control measures.

Code of Federal Regulations, 2012 CFR

2012-07-01

...), must submit the request to EPA via EPA's Central Data Exchange (CDX) using EPA-provided e-PMN software... obtain e-PMN software. Support documents related to these requests must be submitted in the manner set... involved. (5) The specifications of the alternative worker exposure control measures or environmental...

21 CFR 1309.32 - Application forms; contents; signature.

Code of Federal Regulations, 2011 CFR

2011-04-01

... and is not so registered, shall apply on DEA Form 510. (b) Any person who is registered pursuant to Section 1309.21, shall apply for reregistration on DEA Form 510a. (c) DEA Form 510 may be obtained at any... Administration. See the Table of DEA Mailing Addresses in § 1321.01 of this chapter for the current mailing...

Invertebrates in testing of environmental chemicals: are they alternatives?

PubMed Central

Lagadic, L; Caquet, T

1998-01-01

An enlarged interpretation of alternatives in toxicology testing includes the replacement of one animal species with another, preferably a nonmammalian species. This paper reviews the potential of invertebrates in testing environmental chemicals and provides evidence of their usefulness in alternative testing methodologies. The first part of this review addresses the use of invertebrates in laboratory toxicology testing. Problems in extrapolating results obtained in invertebrates to those obtained from vertebrates are noted, suggesting that invertebrates can essentially be used in addition to rather than as replacements for vertebrates in laboratory toxicity tests. However, evaluation of the ecologic impact of environmental chemicals must include defining end points that may frequently differ from those classically used in biomedical research. In this context, alternative approaches using invertebrates may be more pertinent. The second part of the review therefore focuses on the use of invertebrates in situ to assess the environmental impact of pollutants. Advantages of invertebrates in ecotoxicologic investigation are presented for their usefulness for seeking mechanistic links between effects occurring at the individual level and consequences for higher levels of biologic organization (e.g., population and community). In the end, it is considered that replacement of vertebrates by invertebrates in ecotoxicity testing is likely to become a reality when basic knowledge of metabolic, physiologic, and developmental patterns in the latter will be sufficient to assess the effect of a given chemical through end points that could be different between invertebrates and vertebrates. PMID:9599707

Evolutionary conservation and regulation of particular alternative splicing events in plant SR proteins

PubMed Central

Kalyna, Maria; Lopato, Sergiy; Voronin, Viktor; Barta, Andrea

2006-01-01

Alternative splicing is an important mechanism for fine tuning of gene expression at the post-transcriptional level. SR proteins govern splice site selection and spliceosome assembly. The Arabidopsis genome encodes 19 SR proteins, several of which have no orthologues in metazoan. Three of the plant specific subfamilies are characterized by the presence of a relatively long alternatively spliced intron located in their first RNA recognition motif, which potentially results in an extremely truncated protein. In atRSZ33, a member of the RS2Z subfamily, this alternative splicing event was shown to be autoregulated. Here we show that atRSp31, a member of the RS subfamily, does not autoregulate alternative splicing of its similarily positioned intron. Interestingly, this alternative splicing event is regulated by atRSZ33. We demonstrate that the positions of these long introns and their capability for alternative splicing are conserved from green algae to flowering plants. Moreover, in particular alternative splicing events the splicing signals are embedded into highly conserved sequences. In different taxa, these conserved sequences occur in at least one gene within a subfamily. The evolutionary preservation of alternative splice forms together with highly conserved intron features argues for additional functions hidden in the genes of these plant-specific SR proteins. PMID:16936312

Prevalence and factors associated with the use of alternative (folk) medicine practitioners in 8 countries of the former Soviet Union.

PubMed

Stickley, Andrew; Koyanagi, Ai; Richardson, Erica; Roberts, Bayard; Balabanova, Dina; McKee, Martin

2013-04-11

Research suggests that since the collapse of the Soviet Union there has been a sharp growth in the use of complementary and alternative medicine (CAM) in some former Soviet countries. However, as yet, comparatively little is known about the use of CAM in the countries throughout this region. Against this background, the aim of the current study was to determine the prevalence of using alternative (folk) medicine practitioners in eight countries of the former Soviet Union (fSU) and to examine factors associated with their use. Data were obtained from the Living Conditions, Lifestyles and Health (LLH) survey undertaken in eight former Soviet countries (Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia and Ukraine) in 2001. In this nationally representative cross-sectional survey, 18428 respondents were asked about how they treated 10 symptoms, with options including the use of alternative (folk) medicine practitioners. Multivariate logistic regression analysis was used to determine the factors associated with the treatment of differing symptoms by such practitioners in these countries. The prevalence of using an alternative (folk) medicine practitioner for symptom treatment varied widely between countries, ranging from 3.5% in Armenia to 25.0% in Kyrgyzstan. For nearly every symptom, respondents living in rural locations were more likely to use an alternative (folk) medicine practitioner than urban residents. Greater wealth was also associated with using these practitioners, while distrust of doctors played a role in the treatment of some symptoms. The widespread use of alternative (folk) medicine practitioners in some fSU countries and the growth of this form of health care provision in the post-Soviet period in conditions of variable licensing and regulation, highlights the urgent need for more research on this phenomenon and its potential effects on population health in the countries in this region.

Alternative Fuels Data Center: State Alternative Fuel and Advanced Vehicle

Science.gov Websites

Laws and Incentives: 2014 Year in Review State Alternative Fuel and Advanced Vehicle Laws and Fuel and Advanced Vehicle Laws and Incentives: 2014 Year in Review on Facebook Tweet about Alternative Fuels Data Center: State Alternative Fuel and Advanced Vehicle Laws and Incentives: 2014 Year in Review

The Discourse Function of the Greek Future Tense-Form: A Corpus Linguistic Discourse Analysis

ERIC Educational Resources Information Center

Long, Craig M.

2013-01-01

As the Greek verbal system has become the subject of various dissertations and monographs, the future tense-form has been generally overlooked in the discussion. This dissertation seeks to overcome this lacuna by suggesting that the future tense-form functions as a rhetorical feature that expresses the author's expectation of an alternative state…

15 CFR 711.6 - Where to obtain forms.

Code of Federal Regulations, 2014 CFR

2014-01-01

... OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS GENERAL... and Security, U.S. Department of Commerce, Room 4515, 14th Street and Pennsylvania Avenue, NW... Internet at www.cwc.gov. (b) If the amount of information you are required to submit is greater than the...

15 CFR 711.6 - Where to obtain forms.

Code of Federal Regulations, 2013 CFR

2013-01-01

... OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS GENERAL... and Security, U.S. Department of Commerce, Room 4515, 14th Street and Pennsylvania Avenue, NW... Internet at www.cwc.gov. (b) If the amount of information you are required to submit is greater than the...

15 CFR 711.6 - Where to obtain forms.

Code of Federal Regulations, 2012 CFR

2012-01-01

... OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS GENERAL... and Security, U.S. Department of Commerce, Room 4515, 14th Street and Pennsylvania Avenue, NW... Internet at www.cwc.gov. (b) If the amount of information you are required to submit is greater than the...

15 CFR 711.6 - Where to obtain forms.

Code of Federal Regulations, 2011 CFR

2011-01-01

... OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS GENERAL... and Security, U.S. Department of Commerce, Room 4515, 14th Street and Pennsylvania Avenue, NW... Internet at www.cwc.gov. (b) If the amount of information you are required to submit is greater than the...

75 FR 72847 - Agency Forms Submitted for OMB Review, Request for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-26

..., Placement Service. The RRB currently utilizes four forms to obtain information needed to carry out its job... required to obtain or maintain a benefit. In addition, the RRB also collects Railroad Job Vacancies... Control Number: 3220-0057. Form(s) submitted: ES-2, ES-21, ES-21c, UI-35, and Job Vacancies Reports. Type...

Readability of Invasive Procedure Consent Forms.

PubMed

Eltorai, Adam E M; Naqvi, Syed S; Ghanian, Soha; Eberson, Craig P; Weiss, Arnold-Peter C; Born, Christopher T; Daniels, Alan H

2015-12-01

Informed consent is a pillar of ethical medicine which requires patients to fully comprehend relevant issues including the risks, benefits, and alternatives of an intervention. Given the average reading skill of US adults is at the 8th grade level, the American Medical Association (AMA) and the National Institutes of Health (NIH) recommend patient information materials should not exceed a 6th grade reading level. We hypothesized that text provided in invasive procedure consent forms would exceed recommended readability guidelines for medical information. To test this hypothesis, we gathered procedure consent forms from all surgical inpatient hospitals in the state of Rhode Island. For each consent form, readability analysis was measured with the following measures: Flesch Reading Ease Formula, Flesch-Kincaid Grade Level, Fog Scale, SMOG Index, Coleman-Liau Index, Automated Readability Index, and Linsear Write Formula. These readability scores were used to calculate a composite Text Readability Consensus Grade Level. Invasive procedure consent forms were found to be written at an average of 15th grade level (i.e., third year of college), which is significantly higher than the average US adult reading level of 8th grade (p < 0.0001) and the AMA/NIH recommended readability guidelines for patient materials of 6th grade (p < 0.0001). Invasive procedure consent forms have readability levels which makes comprehension difficult or impossible for many patients. Efforts to improve the readability of procedural consent forms should improve patient understanding regarding their healthcare decisions. © 2015 Wiley Periodicals, Inc.

The role of yttrium and titanium during the development of ODS ferritic steels obtained through the STARS route: TEM and XAS study

NASA Astrophysics Data System (ADS)

Ordás, Nerea; Gil, Emma; Cintins, Arturs; de Castro, Vanessa; Leguey, Teresa; Iturriza, Iñigo; Purans, Juris; Anspoks, Andris; Kuzmin, Alexei; Kalinko, Alexandr

2018-06-01

Oxide Dispersion Strengthened Ferritic Steels (ODS FS) are candidate materials for structural components in future fusion reactors. Their high strength and creep resistance at elevated temperatures and their good resistance to neutron radiation damage is obtained through extremely fine microstructures containing a high density of nanometric precipitates, generally yttrium and titanium oxides. This work shows transmission electron microscopy (TEM) and extended X-ray absorption fine structure (EXAFS) characterization of Fe-14Cr-2W-0.3Ti-0.24Y ODS FS obtained by the STARS route (Surface Treatment of gas Atomized powder followed by Reactive Synthesis), an alternative method to obtain ODS alloys that avoids the mechanical alloying to introduce Y2O3 powder particles. In this route, FS powders already containing Ti and Y, precursors of the nanometric oxides, are obtained by gas atomization. Then, a metastable Cr- and Fe-rich oxide layer is formed on the surface of the powder particles. During consolidation by HIP at elevated temperatures, and post-HIP heat treatments above the HIP temperature, this oxide layer at Prior Particle Boundaries (PPBs) dissociates, the oxygen diffuses, and Y-Ti-O nano-oxides precipitate in the ferritic matrix. TEM characterization combined with XAFS and XANES analyses have proven to be suitable tools to follow the evolution of the nature of the different oxides present in the material during the whole processing route and select appropriate HIP and post-HIP parameters to promote profuse and fine Y-Ti-O nanometric precipitates.

Pesticide Registration Manual: How to Obtain a Company Number and Register an Official Address

EPA Pesticide Factsheets

Registrants must obtain a company number before registering their first product with the Agency. Registrants or others who plan to “produce” pesticides or devices must obtain the company number first, then submit EPA Form 3540-8. Find out how to do this.

A numerical analysis on forming limits during spiral and concentric single point incremental forming

NASA Astrophysics Data System (ADS)

Gipiela, M. L.; Amauri, V.; Nikhare, C.; Marcondes, P. V. P.

2017-01-01

Sheet metal forming is one of the major manufacturing industries, which are building numerous parts for aerospace, automotive and medical industry. Due to the high demand in vehicle industry and environmental regulations on less fuel consumption on other hand, researchers are innovating new methods to build these parts with energy efficient sheet metal forming process instead of conventionally used punch and die to form the parts to achieve the lightweight parts. One of the most recognized manufacturing process in this category is Single Point Incremental Forming (SPIF). SPIF is the die-less sheet metal forming process in which the single point tool incrementally forces any single point of sheet metal at any process time to plastic deformation zone. In the present work, finite element method (FEM) is applied to analyze the forming limits of high strength low alloy steel formed by single point incremental forming (SPIF) by spiral and concentric tool path. SPIF numerical simulations were model with 24 and 29 mm cup depth, and the results were compare with Nakajima results obtained by experiments and FEM. It was found that the cup formed with Nakajima tool failed at 24 mm while cups formed by SPIF surpassed the limit for both depths with both profiles. It was also notice that the strain achieved in concentric profile are lower than that in spiral profile.

On the effects of alternative optima in context-specific metabolic model predictions

PubMed Central

Nikoloski, Zoran

2017-01-01

The integration of experimental data into genome-scale metabolic models can greatly improve flux predictions. This is achieved by restricting predictions to a more realistic context-specific domain, like a particular cell or tissue type. Several computational approaches to integrate data have been proposed—generally obtaining context-specific (sub)models or flux distributions. However, these approaches may lead to a multitude of equally valid but potentially different models or flux distributions, due to possible alternative optima in the underlying optimization problems. Although this issue introduces ambiguity in context-specific predictions, it has not been generally recognized, especially in the case of model reconstructions. In this study, we analyze the impact of alternative optima in four state-of-the-art context-specific data integration approaches, providing both flux distributions and/or metabolic models. To this end, we present three computational methods and apply them to two particular case studies: leaf-specific predictions from the integration of gene expression data in a metabolic model of Arabidopsis thaliana, and liver-specific reconstructions derived from a human model with various experimental data sources. The application of these methods allows us to obtain the following results: (i) we sample the space of alternative flux distributions in the leaf- and the liver-specific case and quantify the ambiguity of the predictions. In addition, we show how the inclusion of ℓ1-regularization during data integration reduces the ambiguity in both cases. (ii) We generate sets of alternative leaf- and liver-specific models that are optimal to each one of the evaluated model reconstruction approaches. We demonstrate that alternative models of the same context contain a marked fraction of disparate reactions. Further, we show that a careful balance between model sparsity and metabolic functionality helps in reducing the discrepancies between alternative

On the effects of alternative optima in context-specific metabolic model predictions.

PubMed

Robaina-Estévez, Semidán; Nikoloski, Zoran

2017-05-01

The integration of experimental data into genome-scale metabolic models can greatly improve flux predictions. This is achieved by restricting predictions to a more realistic context-specific domain, like a particular cell or tissue type. Several computational approaches to integrate data have been proposed-generally obtaining context-specific (sub)models or flux distributions. However, these approaches may lead to a multitude of equally valid but potentially different models or flux distributions, due to possible alternative optima in the underlying optimization problems. Although this issue introduces ambiguity in context-specific predictions, it has not been generally recognized, especially in the case of model reconstructions. In this study, we analyze the impact of alternative optima in four state-of-the-art context-specific data integration approaches, providing both flux distributions and/or metabolic models. To this end, we present three computational methods and apply them to two particular case studies: leaf-specific predictions from the integration of gene expression data in a metabolic model of Arabidopsis thaliana, and liver-specific reconstructions derived from a human model with various experimental data sources. The application of these methods allows us to obtain the following results: (i) we sample the space of alternative flux distributions in the leaf- and the liver-specific case and quantify the ambiguity of the predictions. In addition, we show how the inclusion of ℓ1-regularization during data integration reduces the ambiguity in both cases. (ii) We generate sets of alternative leaf- and liver-specific models that are optimal to each one of the evaluated model reconstruction approaches. We demonstrate that alternative models of the same context contain a marked fraction of disparate reactions. Further, we show that a careful balance between model sparsity and metabolic functionality helps in reducing the discrepancies between alternative

Hair as an alternative matrix in bioanalysis.

PubMed

Barbosa, Joana; Faria, Juliana; Carvalho, Félix; Pedro, Madalena; Queirós, Odília; Moreira, Roxana; Dinis-Oliveira, Ricardo Jorge

2013-04-01

Alternative matrices are steadily gaining recognition as biological samples for toxicological analyses. Hair presents many advantages over traditional matrices, such as urine and blood, since it provides retrospective information regarding drug exposure, can distinguish between chronic and acute or recent drug use by segmental analysis, is easy to obtain, and has considerable stability for long periods of time. For this reason, it has been employed in a wide variety of contexts, namely to evaluate workplace drug exposure, drug-facilitated sexual assault, pre-natal drug exposure, anti-doping control, pharmacological monitoring and alcohol abuse. In this article, issues concerning hair structure, collection, storage and analysis are reviewed. The mechanisms of drug incorporation into hair are briefly discussed. Analytical techniques for simultaneous drug quantification in hair are addressed. Finally, representative examples of drug quantification using hair are summarized, emphasizing its potentialities and limitations as an alternative biological matrix for toxicological analyses.

Alternative Fuels Data Center

Science.gov Websites

AFDC » Tools Printable Version Share this resource Send a link to Alternative Fuels Data Center to someone by E-mail Share Alternative Fuels Data Center on Facebook Tweet about Alternative Fuels Data on Delicious Rank Alternative Fuels Data Center on Digg Find More places to share Alternative Fuels

[Alternatives to presently established forms of animal body removal-- tolerated, intended and feared?].

PubMed

Kamphues, J

1997-07-01

The removal and disposal of dead animals and slaughterhouse offalls by rendering plants to produce meat and bone meal (high nutritive value due to the protein and mineral content) is a model for a successful concept of recycling organic matter. Especially since the discussion on BSE and on the role of meat meal in distribution of this disease the products--inspite of their nutritive value--came under criticism. Besides this development more and more owners of companion animals refuse the removal of their animals by rendering plants, increasing their demand of other kinds of disposal (crematorium, burial-grounds). The image of meat and bone meal has been reduced in the last years, although the animal production causes the mass of mortalities and slaughterhouse offals there is a trend to renounce on the use of meat and bone meal in food producing animals. From the ecological and economical point of view it is irresponsible to use a meat and bone meal--produced under specified conditions concerning temperature, pressure and duration of heat treatment--as fuel. Alternative kinds of disposal of dead animals (for example composting) are presented and discussed with their advantages and drawbacks, especially their risks from spreading infectious organisms and diseases.

Imaginary alternatives: The effects of mental simulation on powerless negotiators.

PubMed

Schaerer, Michael; Schweinsberg, Martin; Swaab, Roderick I

2018-03-29

This research demonstrates that people can act more powerfully without having power. Researchers and practitioners advise people to obtain alternatives in social exchange relationships to enhance their power. However, alternatives are not always readily available, often forcing people to interact without having much power. Building on research suggesting that subjective power and objective outcomes are disconnected and that mental simulation can improve aspirations, we show that the mental imagery of a strong alternative can provide some of the benefits that real alternatives provide. We tested this hypothesis in one context of social exchange-negotiations-and demonstrate that imagining strong alternatives (vs. not) causes powerless individuals to negotiate more ambitiously. Negotiators reached more profitable agreements when they had a stronger tendency to simulate alternatives (Study 1) or when they were instructed to simulate an alternative (Studies 3-6). Mediation analyses suggest that mental simulation enhanced performance because it boosted negotiators' aspirations and subsequent first offers (Studies 2-6), but only when the simulated alternative was attractive (Study 5). We used various negotiation contexts, which also allowed us to identify important boundary conditions of mental simulations in interdependent settings: mental simulation no longer helped when negotiators did not make the first offer, when their opponents simultaneously engaged in mental simulation (Study 6), and even backfired in settings where negotiators' positions were difficult to reconcile (Study 7). An internal meta-analysis of the file-drawer produces conservative effect size estimates and demonstrates the robustness of the effect. We contribute to social power, negotiations, and mental simulation research. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Development of a Simple RP-HPLC-UV Method for Determination of Azithromycin in Bulk and Pharmaceutical Dosage forms as an Alternative to the USP Method

PubMed Central

Ghari, Tayebeh; Kobarfard, Farzad; Mortazavi, Seyed Alireza

2013-01-01

The present study was designed to develop a simple, validated liquid chromatographic method for the analysis of azithromycin in bulk and pharmaceutical dosage forms using ultraviolet detector. The best stationary phase was determined as C18 column, 5 μm, 250 mm × 4.6 mm. Mobile phase was optimized to obtain a fast and selective separation of the drug. Flow rate was 1.5 mL/min, Wavelength was set at 210 nm and the volume of each injection was 500 μL. An isocratic methanol/buffer mobile phase at the ratio of 90:10 v/v gave the best separation and resolution. The proposed method was accurate, precise, sensitive, and linear over a wide range of concentration of azithromycin. The developed method has the advantage of using UV detector compared to the USP method in which electrochemical detector has been used. The validated method was successfully applied to the determination of azithromycin in bulk and pharmaceutical dosage forms. PMID:24250672

The clinical and molecular genetic features of idiopathic infantile periodic alternating nystagmus

PubMed Central

Thomas, Mervyn G.; Crosier, Moira; Lindsay, Susan; Kumar, Anil; Thomas, Shery; Araki, Masasuke; Talbot, Chris J.; McLean, Rebecca J.; Surendran, Mylvaganam; Taylor, Katie; Leroy, Bart P.; Moore, Anthony T.; Hunter, David G.; Hertle, Richard W.; Tarpey, Patrick; Langmann, Andrea; Lindner, Susanne; Brandner, Martina

2011-01-01

Periodic alternating nystagmus consists of involuntary oscillations of the eyes with cyclical changes of nystagmus direction. It can occur during infancy (e.g. idiopathic infantile periodic alternating nystagmus) or later in life. Acquired forms are often associated with cerebellar dysfunction arising due to instability of the optokinetic-vestibular systems. Idiopathic infantile periodic alternating nystagmus can be familial or occur in isolation; however, very little is known about the clinical characteristics, genetic aetiology and neural substrates involved. Five loci (NYS1-5) have been identified for idiopathic infantile nystagmus; three are autosomal (NYS2, NYS3 and NYS4) and two are X-chromosomal (NYS1 and NYS5). We previously identified the FRMD7 gene on chromosome Xq26 (NYS1 locus); mutations of FRMD7 are causative of idiopathic infantile nystagmus influencing neuronal outgrowth and development. It is unclear whether the periodic alternating nystagmus phenotype is linked to NYS1, NYS5 (Xp11.4-p11.3) or a separate locus. From a cohort of 31 X-linked families and 14 singletons (70 patients) with idiopathic infantile nystagmus we identified 10 families and one singleton (21 patients) with periodic alternating nystagmus of which we describe clinical phenotype, genetic aetiology and neural substrates involved. Periodic alternating nystagmus was not detected clinically but only on eye movement recordings. The cycle duration varied from 90 to 280 s. Optokinetic reflex was not detectable horizontally. Mutations of the FRMD7 gene were found in all 10 families and the singleton (including three novel mutations). Periodic alternating nystagmus was predominantly associated with missense mutations within the FERM domain. There was significant sibship clustering of the phenotype although in some families not all affected members had periodic alternating nystagmus. In situ hybridization studies during mid-late human embryonic stages in normal tissue showed restricted

National Park Service's Alternative Transportation Program : Pilot Data Collection Summary and Future Recommendations.

DOT National Transportation Integrated Search

2006-03-31

In the summer of 2002 an interagency, multi-disciplinary team was formed to develop a plan for defining and collecting performance data needed for better managing the National Park Services (NPS) Alternative Transportation Program (ATP). Members o...

Chemical Composition and Antioxidant Properties of Powders Obtained from Different Plum Juice Formulations.

PubMed

Michalska, Anna; Wojdyło, Aneta; Łysiak, Grzegorz P; Figiel, Adam

2017-01-17

Among popular crops, plum ( Prunus domestica L.) has received special attention due to its health-promoting properties. The seasonality of this fruit makes it impossible to consume it throughout the year, so new products in a powder form may offer an alternative to fresh consumption and may be used as high-quality natural food ingredients. A 100% plum (cultivar "Valor") juice was mixed with three different concentrations of maltodextrin or subjected to sugars removal by amberlite-XAD column, and dried using the freeze, spray, and vacuum (40, 60, and 80 °C) drying techniques. The identification and quantification of phenolic acids, flavonols, and anthocyanins in plum powders was performed by LC-MS QTof and UPLC-PDA, respectively. l-ascorbic acid, hydroxymethylfurfural, and antioxidant capacity were measured by the Trolox equivalent antioxidant capacity (TEAC) ABTS and ferric reducing antioxidant potential (FRAP) methods in order to compare the influence of the drying methods on product quality. The results indicated that the profile of polyphenolic compounds in the plum juice powders significantly differed from the whole plum powders. The drying of a sugar free plum extract resulted in higher content of polyphenolic compounds, l-ascorbic acid and antioxidant capacity, but lower content of hydroxymethylfurfural, regardless of drying method applied. Thus, the formulation of plum juice before drying and the drying method should be carefully selected in order to obtain high-quality powders.

Canonical forms of multidimensional steady inviscid flows

NASA Technical Reports Server (NTRS)

Taasan, Shlomo

1993-01-01

Canonical forms and canonical variables for inviscid flow problems are derived. In these forms the components of the system governed by different types of operators (elliptic and hyperbolic) are separated. Both the incompressible and compressible cases are analyzed, and their similarities and differences are discussed. The canonical forms obtained are block upper triangular operator form in which the elliptic and non-elliptic parts reside in different blocks. The full nonlinear equations are treated without using any linearization process. This form enables a better analysis of the equations as well as better numerical treatment. These forms are the analog of the decomposition of the one dimensional Euler equations into characteristic directions and Riemann invariants.

Assessment "Honest Alternatives".

ERIC Educational Resources Information Center

Mandel, Susan Glazer

1995-01-01

Addresses the challenge of finding or creating alternatives to tests and traditional grading systems. Reflects on and describes the experience of creating an assessment tool and cautions against choosing alternatives that merely camouflage the grades. Encourages educators to find authentic alternatives to describe children's growth. (BAC)

Quadratic forms involving Green's and Robin functions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dubinin, Vladimir N

2009-10-31

General inequalities for quadratic forms with coefficients depending on the values of Green's and Robin functions are obtained. These inequalities cover also the reduced moduli of strips and half-strips. Some applications of the results obtained to extremal partitioning problems and related questions of geometric function theory are discussed. Bibliography: 29 titles.

NDA issues with RFETS vitrified waste forms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hurd, J.; Veazey, G.

1998-12-31

A study was conducted at Los Alamos National Laboratory (LANL) for the purpose of determining the feasibility of using a segmented gamma scanner (SGS) to accurately perform non-destructive analysis (NDA) on certain Rocky Flats Environmental Technology Site (RFETS) vitrified waste samples. This study was performed on a full-scale vitrified ash sample prepared at LANL according to a procedure similar to that anticipated to be used at RFETS. This sample was composed of a borosilicate-based glass frit, blended with ash to produce a Pu content of {approximately}1 wt %. The glass frit was taken to a degree of melting necessary tomore » achieve a full encapsulation of the ash material. The NDA study performed on this sample showed that SGSs with either {1/2}- or 2-inch collimation can achieve an accuracy better than 6 % relative to calorimetry and {gamma}-ray isotopics. This accuracy is achievable, after application of appropriate bias corrections, for transmissions of about {1/2} % through the waste form and counting times of less than 30 minutes. These results are valid for ash material and graphite fines with the same degree of plutonium particle size, homogeneity, sample density, and sample geometry as the waste form used to obtain the results in this study. A drum-sized thermal neutron counter (TNC) was also included in the study to provide an alternative in the event the SGS failed to meet the required level of accuracy. The preliminary indications are that this method will also achieve the required accuracy with counting times of {approximately}30 minutes and appropriate application of bias corrections. The bias corrections can be avoided in all cases if the instruments are calibrated on standards matching the items.« less

An Examination of the Transformative Learning Potential of Alternative Spring Breaks

ERIC Educational Resources Information Center

Mann, Jessica; DeAngelo, Linda

2016-01-01

As institutions seek to offer students an educational experience equipped with opportunities to develop as not only active learners but also engaged citizens, service-learning initiatives in the form of alternative spring breaks (ASB) have become prevalent. This study examines the potential of ASBs, as service-learning initiatives, to deliver a…

Alternate forms of the associated Legendre functions for use in geomagnetic modeling.

USGS Publications Warehouse

Alldredge, L.R.; Benton, E.R.

1986-01-01

An inconvenience attending traditional use of associated Legendre functions in global modeling is that the functions are not separable with respect to the 2 indices (order and degree). In 1973 Merilees suggested a way to avoid the problem by showing that associated Legendre functions of order m and degree m+k can be expressed in terms of elementary functions. This note calls attention to some possible gains in time savings and accuracy in geomagnetic modeling based upon this form. For this purpose, expansions of associated Legendre polynomials in terms of sines and cosines of multiple angles are displayed up to degree and order 10. Examples are also given explaining how some surface spherical harmonics can be transformed into true Fourier series for selected polar great circle paths. -from Authors

A convolution model for obtaining the response of an ionization chamber in static non standard fields

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gonzalez-Castano, D. M.; Gonzalez, L. Brualla; Gago-Arias, M. A.

2012-01-15

Purpose: This work contains an alternative methodology for obtaining correction factors for ionization chamber (IC) dosimetry of small fields and composite fields such as IMRT. The method is based on the convolution/superposition (C/S) of an IC response function (RF) with the dose distribution in a certain plane which includes chamber position. This method is an alternative to the full Monte Carlo (MC) approach that has been used previously by many authors for the same objective. Methods: The readout of an IC at a point inside a phantom irradiated by a certain beam can be obtained as the convolution of themore » dose spatial distribution caused by the beam and the IC two-dimensional RF. The proposed methodology has been applied successfully to predict the response of a PTW 30013 IC when measuring different nonreference fields, namely: output factors of 6 MV small fields, beam profiles of cobalt 60 narrow fields and 6 MV radiosurgery segments. The two-dimensional RF of a PTW 30013 IC was obtained by MC simulation of the absorbed dose to cavity air when the IC was scanned by a 0.6 x 0.6 mm{sup 2} cross section parallel pencil beam at low depth in a water phantom. For each of the cases studied, the results of the IC direct measurement were compared with the corresponding obtained by the C/S method. Results: For all of the cases studied, the agreement between the IC direct measurement and the IC calculated response was excellent (better than 1.5%). Conclusions: This method could be implemented in TPS in order to calculate dosimetry correction factors when an experimental IMRT treatment verification with in-phantom ionization chamber is performed. The miss-response of the IC due to the nonreference conditions could be quickly corrected by this method rather than employing MC derived correction factors. This method can be considered as an alternative to the plan-class associated correction factors proposed recently as part of an IAEA work group on nonstandard field

Chicano Alternative Education.

ERIC Educational Resources Information Center

Galicia, H. Homero; Almaguer, Clementina

Alternative schooling is challenging some basic notions of curriculum, operation, and structure of traditional schools; it is not challenging the basic concept of schooling. Chicano alternative education, an elusive concept, lacks a precise definition. Chicano alternative schools reflect a vast diversity in structure, focus, and goals. The Chicano…

Alternative accounting in maternal and infant global health.

PubMed

Adams, Vincanne; Craig, Sienna R; Samen, Arlene

2015-03-18

Efforts to augment accountability through the use of metrics, and especially randomised controlled trial or other statistical methods place an increased burden on small nongovernmental organisations (NGOs) doing global health. In this paper, we explore how one small NGO works to generate forms of accountability and evidence that may not conform to new metrics trends but nevertheless deserve attention and scrutiny for being effective, practical and reliable in the area of maternal and infant health. Through an analysis of one NGO and, in particular, its organisational and ethical principles for creating a network of safety for maternal and child health, we argue that alternative forms of (ac)counting like these might provide useful evidence of another kind of successful global health work.

76 FR 21673 - Alternative Efficiency Determination Methods and Alternate Rating Methods

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-18

... EERE-2011-BP-TP-00024] RIN 1904-AC46 Alternative Efficiency Determination Methods and Alternate Rating Methods AGENCY: Office of Energy Efficiency and Renewable Energy, Department of Energy. ACTION: Notice of... and data related to the use of computer simulations, mathematical methods, and other alternative...

45 CFR 148.128 - State flexibility in individual market reforms-alternative mechanisms.

Code of Federal Regulations, 2011 CFR

2011-10-01

... mechanism (such as a health insurance coverage pool or program, a mandatory group conversion policy... of the following requirements? (i) Is the policy form comparable to comprehensive health insurance...-alternative mechanisms. 148.128 Section 148.128 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES...

45 CFR 148.128 - State flexibility in individual market reforms-alternative mechanisms.