Sample records for obtain preliminary evidence

  1. A preliminary look at techniques used to obtain airdata from flight at high angles of attack

    NASA Technical Reports Server (NTRS)

    Moes, Timothy R.; Whitmore, Stephen A.

    1990-01-01

    Flight research at high angles of attack has posed new problems for airdata measurements. New sensors and techniques for measuring the standard airdata quantities of static pressure, dynamic pressure, angle of attack, and angle of sideslip were subsequently developed. The ongoing airdata research supporting NASA's F-18 high alpha research program is updated. Included are the techniques used and the preliminary results. The F-18 aircraft was flown with three research airdata systems: a standard airdata probe on the right wingtip, a self-aligning airdata probe on the left wingtip, and a flush airdata system on the nose cone. The primary research goal was to obtain steady-state calibrations for each airdata system up to an angle of attack of 50 deg. This goal was accomplished and preliminary accuracies of the three airdata systems were assessed and are presented. An effort to improve the fidelity of the airdata measurements during dynamic maneuvering is also discussed. This involved enhancement of the aerodynamic data with data obtained from linear accelerometers, rate gyros, and attitude gyros. Preliminary results of this technique are presented.

  2. Development and Validation of the Evidence-Based Practice Process Assessment Scale: Preliminary Findings

    ERIC Educational Resources Information Center

    Rubin, Allen; Parrish, Danielle E.

    2010-01-01

    Objective: This report describes the development and preliminary findings regarding the reliability, validity, and sensitivity of a scale that has been developed to assess practitioners' perceived familiarity with, attitudes about, and implementation of the phases of the evidence-based practice (EBP) process. Method: After a panel of national…

  3. Internet Self-Exclusion: Characteristics of Self-Excluded Gamblers and Preliminary Evidence for Its Effectiveness

    ERIC Educational Resources Information Center

    Hayer, Tobias; Meyer, Gerhard

    2011-01-01

    Preliminary scientific evidence indicates that online gamblers are more likely to be problem gamblers and thus point to the need for effective protection measures. This study focuses on an online self-exclusion program and seeks to comprehensively examine the benefits of this measure. It was intended to collect detailed information on the…

  4. School Improvement Plans and Student Achievement: Preliminary Evidence from the Quality and Merit Project in Italy

    ERIC Educational Resources Information Center

    Caputo, Andrea; Rastelli, Valentina

    2014-01-01

    This study provides preliminary evidence from an Italian in-service training program addressed to lower secondary school teachers which supports school improvement plans (SIPs). It aims at exploring the association between characteristics/contents of SIPs and student improvement in math achievement. Pre-post standardized tests and text analysis of…

  5. Neuroplasticity of selective attention: Research foundations and preliminary evidence for a gene by intervention interaction

    PubMed Central

    Stevens, Courtney; Pakulak, Eric; Hampton Wray, Amanda; Bell, Theodore A.; Neville, Helen J.

    2017-01-01

    This article reviews the trajectory of our research program on selective attention, which has moved from basic research on the neural processes underlying selective attention to translational studies using selective attention as a neurobiological target for evidence-based interventions. We use this background to present a promising preliminary investigation of how genetic and experiential factors interact during development (i.e., gene × intervention interactions). Our findings provide evidence on how exposure to a family-based training can modify the associations between genotype (5-HTTLPR) and the neural mechanisms of selective attention in preschool children from lower socioeconomic status backgrounds. PMID:28819066

  6. Neuroplasticity of selective attention: Research foundations and preliminary evidence for a gene by intervention interaction.

    PubMed

    Isbell, Elif; Stevens, Courtney; Pakulak, Eric; Hampton Wray, Amanda; Bell, Theodore A; Neville, Helen J

    2017-08-29

    This article reviews the trajectory of our research program on selective attention, which has moved from basic research on the neural processes underlying selective attention to translational studies using selective attention as a neurobiological target for evidence-based interventions. We use this background to present a promising preliminary investigation of how genetic and experiential factors interact during development (i.e., gene × intervention interactions). Our findings provide evidence on how exposure to a family-based training can modify the associations between genotype (5-HTTLPR) and the neural mechanisms of selective attention in preschool children from lower socioeconomic status backgrounds.

  7. Preliminary evidence for validity of the Bahasa Indonesian version of Study Process Questionnaire.

    PubMed

    Liem, Arief Darmanegara; Prasetya, Paulus Hidajat

    2007-02-01

    This study provides preliminary evidence for the validity of the Bahasa Indonesian version of the Study Process Questionnaire (BI-SPQ) from a sample of 147 psychology students (22 men and 125 women; M age = 21.8 yr., SD = 1.3). The internal consistency alpha of the BI-SPQ subscales were found to range from .46 (Surface Strategy) to .77 (Deep Strategy), with a median of .67. Principal component analysis indicated a two-factor solution, where the Deep and Achieving subscales loaded onto Factor 1 and the Surface subscales loaded on Factor 2. Students' GPAs were associated negatively with Surface Motive (r = -.24) and were associated positively with Deep and Achieving Motives (rs = .20). Further studies with larger samples involving students majoring in other disciplines are needed to provide further evidence of the validity of the BI-SPQ.

  8. 20 CFR 416.1014 - Responsibilities for obtaining evidence to make disability determinations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Responsibilities for obtaining evidence to make disability determinations. 416.1014 Section 416.1014 Employees' Benefits SOCIAL SECURITY... those classes of cases described in the written guidelines for which the State agency does not make the...

  9. Preliminary Evidence Supports Modification of Retraction Technique to Prevent Needlestick Injuries

    PubMed Central

    Fa, Bernadette Alvear; Cuny, Eve

    2016-01-01

    A modified retraction technique was introduced into the DDS degree preclinical anesthesia course in 2011 with the goal of reducing needlestick exposure incidents. In numerous studies of dental exposures, injuries from dental anesthetic needles account for the highest proportion of all exposures. The purpose of this study was to assess the preliminary impact of a modified retraction technique on the incidence of blood and body fluids (BBF) exposure incidents associated with needles during injection. Data from evaluations of students from 2014 and 2015 were obtained and tracked to determine whether the modified retraction technique was “excellent,” “clinically acceptable,” or “clinically unacceptable.” Data were collected to determine if the patient perceived the modified retraction technique as “comfortable” or “correctable when addressed” to help improve student technique for future injections. Likewise, data from the blood-borne exposure database where all information related to BBF exposures is recorded were reviewed and the information separated by year and class. This study presents preliminary data only and because of the small sample size does not lend itself to validation by statistical analysis. However, the technique effectively removes the operator's hand from the field during injection, reducing the risk of accidental intraoral needlestick to the nondominant hand of the operator. PMID:27973940

  10. Obtaining evidence for use by healthcare payers on the success of chronic obstructive pulmonary disease management.

    PubMed

    Mapel, D; Pearson, M

    2002-08-01

    Healthcare payers make decisions on funding for treatments for diseases, such as chronic obstructive pulmonary disease (COPD), on a population level, so require evidence of treatment success in appropriate populations, using usual routine care as the comparison for alternative management approaches. Such health outcomes evidence can be obtained from a number of sources. The 'gold standard' method for obtaining evidence of treatment success is usually taken as the randomized controlled prospective clinical trial. Yet the value of such studies in providing evidence for decision-makers can be questioned due to the restricted entry criteria limiting the ability to generalize to real life populations, narrow focus on individual parameters, use of placebo for comparison rather than usual therapy and unrealistic intense monitoring of patients. Evidence obtained from retrospective and observational studies can supplement that from randomized clinical trials, providing that care is taken to guard against bias and confounders. However, very large numbers of patients must be investigated if small differences between drugs and treatment approaches are to be detected. Administrative databases from healthcare systems provide an opportunity to obtain observational data on large numbers of patients. Such databases have shown that high healthcare costs in patients with COPD are associated with co-morbid conditions and current smoking status. Analysis of an administrative database has also shown that elderly patients with COPD who received inhaled corticosteroids within 90 days of discharge from hospital had 24% fewer repeat hospitalizations for COPD and were 29% less likely to die during the 1-year follow-up period. In conclusion, there are a number of sources of meaningful evidence of the health outcomes arising from different therapeutic approaches that should be of value to healthcare payers making decisions on resource allocation.

  11. What is driving rates of social policy preliminary references to the CJEU? Evidence from the United Kingdom and France

    PubMed Central

    Sigafoos, Jennifer

    2013-01-01

    Preliminary references to the Court of Justice for the European Union are unevenly distributed across the EU, creating differing access to justice for European citizens. This study presents case studies of the UK and France, exploring factors affecting rates of social policy preliminary references from 1996–2009. The UK had a rate twice that of France. What accounts for this difference? Analysis of documentary evidence and 25 expert interviews help to explain the differing rates. Themes were related to policy, structural factors and the agency of actors. In the UK, policy themes are the free movement of persons and the ‘Right to Reside’ test. Legal aid and legal NGOs help individuals access the Court and drive test case strategies. In France, a high degree of dualisation in the welfare state creates an insider/outsider dynamic. Coupled with the resistance of courts and a lack of comparable actors to drive preliminary references, this contributes to a lower rate of references. PMID:23565042

  12. Preliminary evidence that testosterone's association with aggression depends on self-construal.

    PubMed

    Welker, Keith M; Norman, Rachel E; Goetz, Stefan; Moreau, Benjamin J P; Kitayama, Shinobu; Carré, Justin M

    2017-06-01

    A contribution to a special issue on Hormones and Human Competition. Previous research and theory suggest testosterone is an important hormone for modulating aggression and self-regulation. We propose that self-construal, a culturally-relevant difference in how individuals define the self in relation to others, may be an important moderator of the relationship between testosterone and behaviors linked to aggression. Within two studies (Study 1 N=80; Study 2 N=237) and an integrated data analysis, we find evidence suggesting that acute testosterone changes in men are positively associated with aggressive behavior for those with more independent self-construals, whereas basal testosterone is negatively associated with aggression when individuals have more interdependent self-construals. Although preliminary, these findings suggest that self-construal moderates the association between testosterone and aggression, thereby paving the way toward future work examining the potential cultural moderation of the behavioral effects of testosterone. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Assessing young children's intention-reading in authentic communicative contexts: preliminary evidence and clinical utility.

    PubMed

    Greenslade, Kathryn J; Coggins, Truman E

    2014-01-01

    Identifying what a communication partner is looking at (referential intention) and why (social intention) is essential to successful social communication, and may be challenging for children with social communication deficits. This study explores a clinical task that assesses these intention-reading abilities within an authentic context. To gather evidence of the task's reliability and validity, and to discuss its clinical utility. The intention-reading task was administered to twenty 4-7-year-olds with typical development (TD) and ten with autism spectrum disorder (ASD). Task items were embedded in an authentic activity, and they targeted the child's ability to identify the examiner's referential and social intentions, which were communicated through joint attention behaviours. Reliability and construct validity evidence were addressed using established psychometric methods. Reliability and validity evidence supported the use of task scores for identifying children whose intention-reading warranted concern. Evidence supported the reliability of task administration and coding, and item-level codes were highly consistent with overall task performance. Supporting task validity, group differences aligned with predictions, with children with ASD exhibiting poorer and more variable task scores than children with TD. Also, as predicted, task scores correlated significantly with verbal mental age and ratings of parental concerns regarding social communication abilities. The evidence provides preliminary support for the reliability and validity of the clinical task's scores in assessing young children's real-time intention-reading abilities, which are essential for successful interactions in school and beyond. © 2014 Royal College of Speech and Language Therapists.

  14. Diffusion Imaging of Auditory and Auditory-Limbic Connectivity in Tinnitus: Preliminary Evidence and Methodological Challenges

    PubMed Central

    Seydell-Greenwald, Anna; Raven, Erika P.; Leaver, Amber M.; Turesky, Ted K.; Rauschecker, Josef P.

    2014-01-01

    Subjective tinnitus, or “ringing in the ears,” is perceived by 10 to 15 percent of the adult population and causes significant suffering in a subset of patients. While it was originally thought of as a purely auditory phenomenon, there is increasing evidence that the limbic system influences whether and how tinnitus is perceived, far beyond merely determining the patient's emotional reaction to the phantom sound. Based on functional imaging and electrophysiological data, recent articles frame tinnitus as a “network problem” arising from abnormalities in auditory-limbic interactions. Diffusion-weighted magnetic resonance imaging is a noninvasive method for investigating anatomical connections in vivo. It thus has the potential to provide anatomical evidence for the proposed changes in auditory-limbic connectivity. However, the few diffusion imaging studies of tinnitus performed to date have inconsistent results. In the present paper, we briefly summarize the results of previous studies, aiming to reconcile their results. After detailing analysis methods, we then report findings from a new dataset. We conclude that while there is some evidence for tinnitus-related increases in auditory and auditory-limbic connectivity that counteract hearing-loss related decreases in auditory connectivity, these results should be considered preliminary until several technical challenges have been overcome. PMID:25050181

  15. 43 CFR 3425.1-7 - Preliminary data.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... used is other than underground mining techniques, the authorized officer shall obtain documents... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Preliminary data. 3425.1-7 Section 3425.1... Preliminary data. (a) Any application for a lease shall contain preliminary data to assist the authorized...

  16. 43 CFR 3425.1-7 - Preliminary data.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... used is other than underground mining techniques, the authorized officer shall obtain documents... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Preliminary data. 3425.1-7 Section 3425.1... Preliminary data. (a) Any application for a lease shall contain preliminary data to assist the authorized...

  17. 43 CFR 3425.1-7 - Preliminary data.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... used is other than underground mining techniques, the authorized officer shall obtain documents... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Preliminary data. 3425.1-7 Section 3425.1... Preliminary data. (a) Any application for a lease shall contain preliminary data to assist the authorized...

  18. New high-definition thickness data obtained at tropical glaciers: preliminary results from Antisana volcano (Ecuador) using GPR prospection

    NASA Astrophysics Data System (ADS)

    Zapata, Camilo; Andrade, Daniel; Córdova, Jorge; Maisincho, Luis; Carvajal, Juan; Calispa, Marlon; Villacís, Marcos

    2014-05-01

    The study of tropical glaciers has been a significant contribution to the understanding of glacier dynamics and climate change. Much of the data and results have been obtained by analyzing plan-view images obtained by air- and space-borne sensors, as well as depth data obtained by diverse methodologies at selected points on the glacier surface. However, the measurement of glacier thicknesses has remained an elusive task in tropical glaciers, often located in rough terrains where the application of geophysical surveys (i.e. seismic surveys) requires logistics sometimes hardly justified by the amount of obtained data. In the case of Ecuador, however, where most glaciers have developed on active volcanoes and represent sources/reservoirs of fresh water, the precise knowledge of such information is fundamental for scientific research but also in order to better assess key aspects for the society. The relatively recent but fast development of the GPR technology has helped to obtain new highdefinition thickness data at Antisana volcano that will be used to: 1) better understand the dynamics and fate of tropical glaciers; 2) better estimate the amount of fresh water stored in the glaciers; 3) better assess the hazards associated with the sudden widespread melting of glaciers during volcanic eruptions. The measurements have been obtained at glaciers 12 and 15 of Antisana volcano, with the help of a commercial GPR equipped with a 25 MHz antenna. A total of 30 transects have been obtained, covering a distance of more than 3 km, from the glacier ablation zone, located at ~ 4600 masl, up to the level of 5200 masl. The preliminary results show a positive correlation between altitude and glacier thickness, with maximum and minimum calculated values reaching up to 80 m, and down to 15 m, respectively. The experience gained at Antisana volcano will be used to prepare a more widespread GPR survey in the glaciers of Cotopaxi volcano, whose implications in terms of volcanic hazards

  19. Preliminary evidence of hippocampal damage in chronic users of ecstasy.

    PubMed

    den Hollander, Bjørnar; Schouw, Marieke; Groot, Paul; Huisman, Henk; Caan, Matthan; Barkhof, Frederik; Reneman, Liesbeth

    2012-01-01

    Various studies have shown that ecstasy (3,4-methylenedioxymethamphetamine) users display significant memory impairments, whereas their performance on other cognitive tests is generally normal. The hippocampus plays an essential role in short-term memory. There are, however, no structural human data on the effects of ecstasy on the hippocampus. The objective of this study was to investigate whether the hippocampal volume of chronic ecstasy users is reduced when compared with healthy polydrug-using controls, as an indicator of hippocampal damage. The hippocampus was manually outlined in volumetric MRI scans in 10 male ecstasy users (mean age 25.4 years) and seven healthy age- and gender-matched control subjects (21.3 years). Other than the use of ecstasy, there were no statistically significant differences between both groups in exposure to other drugs of abuse and alcohol. The ecstasy users were on average drug-free for more than 2 months and had used on average 281 tablets over the past six and a half years. The hippocampal volume in the ecstasy using group was on average 10.5% smaller than the hippocampal volume in the control group (p=0.032). These data provide preliminary evidence that ecstasy users may be prone to incurring hippocampal damage, in line with previous reports of acute hippocampal sclerosis and subsequent atrophy in chronic users of this drug.

  20. Preliminary evidence for a 1000-year-old tsunami in the South China Sea

    PubMed Central

    Sun, Liguang; Zhou, Xin; Huang, Wen; Liu, Xiaodong; Yan, Hong; Xie, Zhouqing; Wu, Zijun; Zhao, Sanping; Da Shao; Yang, Wenqing

    2013-01-01

    The risk of large, devastating tsunamis in the South China Sea and its surrounding coastal region is commonly underestimated or unrecognized due to the difficulty of differentiating tsunami from storm deposits. As a consequence, few convincing records have documented tsunami deposits in this region. Here we report preliminary evidence from Xisha Islands in the South China Sea for a large tsunami around AD 1024. Sand layers in lake sediment cores and their geochemical characteristics indicate a sudden deposition event around AD 1024, temporally consistent with a written record of a disastrous event characterized by high waves in AD 1076. Heavy coral and shell fossils, which are older than AD 1024, deposited more than 200 meters into the island, further support the occurrence of a high-energy event such as a tsunami or an unusually large storm. Our results underscore the importance of acknowledging and understanding the tsunami hazard in this area. PMID:23575432

  1. Preliminary evidence for a 1000-year-old tsunami in the South China Sea.

    PubMed

    Sun, Liguang; Zhou, Xin; Huang, Wen; Liu, Xiaodong; Yan, Hong; Xie, Zhouqing; Wu, Zijun; Zhao, Sanping; Da Shao; Yang, Wenqing

    2013-01-01

    The risk of large, devastating tsunamis in the South China Sea and its surrounding coastal region is commonly underestimated or unrecognized due to the difficulty of differentiating tsunami from storm deposits. As a consequence, few convincing records have documented tsunami deposits in this region. Here we report preliminary evidence from Xisha Islands in the South China Sea for a large tsunami around AD 1024. Sand layers in lake sediment cores and their geochemical characteristics indicate a sudden deposition event around AD 1024, temporally consistent with a written record of a disastrous event characterized by high waves in AD 1076. Heavy coral and shell fossils, which are older than AD 1024, deposited more than 200 meters into the island, further support the occurrence of a high-energy event such as a tsunami or an unusually large storm. Our results underscore the importance of acknowledging and understanding the tsunami hazard in this area.

  2. Preliminary evidence that acute stress moderates basal testosterone's association with retaliatory behavior.

    PubMed

    Prasad, Smrithi; Narayanan, Jayanth; Lim, Vivien K G; Koh, Gerald C H; Koh, David S Q; Mehta, Pranjal H

    2017-06-01

    A contribution to a special issue on Hormones and Human Competition. Testosterone is theorized to increase retaliation after social provocation. However, empirical evidence in support of these theories is mixed. The present research investigated whether acute stress causally suppresses testosterone's association with retaliation. We also explored sex differences in behavioral responses to acute stress. Thirty-nine participants (51.28% male) were randomly assigned to a high- or low-stress condition. Then participants engaged in 20 one-shot rounds of the ultimatum game, which was used to assess retaliatory behavioral responses to unfair treatment. Participants provided two saliva samples to measure testosterone and cortisol concentrations - one sample before the stress manipulation, and the second after the ultimatum game (20minutes post-stressor). Results revealed a positive association between basal testosterone and retaliation in the low-stress condition, but not in the high-stress condition. Further, cortisol concentrations increased in the high- compared to the low-stress condition, and these cortisol changes moderated the association between basal testosterone and retaliation. The associations between basal testosterone and retaliation under varying levels of stress were similar in men and women. However, there was a sex difference in behavioral responses to the stress manipulation that was independent of testosterone. In women, the high-stress condition reduced retaliation compared to the low-stress condition, whereas in men the opposite pattern emerged. Collectively, this study (i) provides preliminary evidence that experimentally manipulated stress blocks basal testosterone's association with retaliation, and (ii) reveals a sex difference in retaliation under varying levels of stress. Discussion focuses on mechanisms, limitations, and the need for follow-up studies with larger sample sizes. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Preliminary evidence for biologic activity of toceranib phosphate (Palladia®) in solid tumors

    PubMed Central

    London, Cheryl; Mathie, Tamra; Stingle, Nicole; Clifford, Craig; Haney, Siobhan; Klein, Mary K.; Beaver, Linda; Vickery, Kate; Vail, David M.; Hershey, Betsey; Ettinger, Susan; Vaughan, Andrew; Alvarez, Francisco; Hillman, Lorin; Kiselow, Mike; Thamm, Doug; Higginbotham, Mary Lynn; Gauthier, Meredith; Krick, Erika; Phillips, Brenda; LaDue, Tracy; Jones, Pam; Bryan, Jeffery; Gill, Virginia; Novasad, Andrew; Fulton, Lisa; Carreras, Janet; McNeill, Conor; Henry, Carolyn; Gillings, Sarah

    2013-01-01

    The purpose of this study was to provide an initial assessment of the potential biologic activity of toceranib phosphate (Palladia®) in select solid tumors in dogs. Cases in which toceranib was used to treat dogs with anal sac anal gland adenocarcinoma, metastatic osteosarcoma, thyroid carcinoma, head and neck carcinoma, and nasal carcinoma were included. Clinical benefit (CB) was observed in 63/85 (74%) dogs including 28/32 anal sac tumors (8PR, 20SD), 11/23 osteosarcomas (1PR, 10SD), 12/15 thyroid carcinomas (4PR, 8SD), 7/8 head and neck carcinomas (1CR, 5PR, 1SD) and 5/7 (1CR, 4SD) nasal carcinomas. For dogs experiencing CB, the median dose of toceranib was 2.8 mg/kg, 36/63 (58.7%) were dosed on a Monday/Wednesday/Friday basis, and 47/63 (74.6%) were treated 4 months or longer. While these data povide preliminary evidence that toceranib exhibits CB in dogs with certain solid tumors, future prospective studies are necessary to define its true activity. PMID:22236194

  4. A new evaluation tool to obtain practice-based evidence of worksite health promotion programs.

    PubMed

    Dunet, Diane O; Sparling, Phillip B; Hersey, James; Williams-Piehota, Pamela; Hill, Mary D; Hanssen, Carl; Lawrenz, Frances; Reyes, Michele

    2008-10-01

    The Centers for Disease Control and Prevention developed the Swift Worksite Assessment and Translation (SWAT) evaluation method to identify promising practices in worksite health promotion programs. The new method complements research studies and evaluation studies of evidence-based practices that promote healthy weight in working adults. We used nationally recognized program evaluation standards of utility, feasibility, accuracy, and propriety as the foundation for our 5-step method: 1) site identification and selection, 2) site visit, 3) post-visit evaluation of promising practices, 4) evaluation capacity building, and 5) translation and dissemination. An independent, outside evaluation team conducted process and summative evaluations of SWAT to determine its efficacy in providing accurate, useful information and its compliance with evaluation standards. The SWAT evaluation approach is feasible in small and medium-sized workplace settings. The independent evaluation team judged SWAT favorably as an evaluation method, noting among its strengths its systematic and detailed procedures and service orientation. Experts in worksite health promotion evaluation concluded that the data obtained by using this evaluation method were sufficient to allow them to make judgments about promising practices. SWAT is a useful, business-friendly approach to systematic, yet rapid, evaluation that comports with program evaluation standards. The method provides a new tool to obtain practice-based evidence of worksite health promotion programs that help prevent obesity and, more broadly, may advance public health goals for chronic disease prevention and health promotion.

  5. Prenatal Exposure Effects on Early Adolescent Substance Use: Preliminary Evidence From a Genetically Informed Bayesian Approach.

    PubMed

    Bidwell, L Cinnamon; Marceau, Kristine; Brick, Leslie A; Karoly, Hollis C; Todorov, Alexandre A; Palmer, Rohan H; Heath, Andrew C; Knopik, Valerie S

    2017-09-01

    Given the controversy surrounding the question of whether there are direct or causal effects of exposure to maternal smoking during pregnancy (SDP) on offspring outcomes such as substance use during the adolescent years, we sought to test, on a preliminary basis, within- and between-family associations of SDP and initiation of substance use early in adolescence (by age 15 years) using a discordant sibling design. We used a sibling-comparison approach in a sample of 173 families drawn from the state of Missouri, wherein mothers were discordant for smoking behaviors between two different pregnancies, to test for associations of SDP and initiation of substance use in a younger adolescent cohort. The discordant sibling comparison approach allows for disentangling familial effects from direct effects of SDP through the purposeful collection of data from siblings within the same family with differential exposure. There were no between- or within-family effects of SDP on initiation of any type of substance use (alcohol, marijuana, smoking, and other drug classes), suggesting that SDP does not exert a direct effect on substance use in early adolescence. Preliminary findings did not support an association of SDP and initiation of substance use in this younger adolescent sample. Studies such as this one can help build a body of evidence to explain whether associations of SDP and adolescent outcomes reflect a direct effect of SPD or may instead be attributable to familial confounders that are controlled in the discordant sibling design.

  6. Preliminary evidence for biologic activity of toceranib phosphate (Palladia(®)) in solid tumours.

    PubMed

    London, C; Mathie, T; Stingle, N; Clifford, C; Haney, S; Klein, M K; Beaver, L; Vickery, K; Vail, D M; Hershey, B; Ettinger, S; Vaughan, A; Alvarez, F; Hillman, L; Kiselow, M; Thamm, D; Higginbotham, M L; Gauthier, M; Krick, E; Phillips, B; Ladue, T; Jones, P; Bryan, J; Gill, V; Novasad, A; Fulton, L; Carreras, J; McNeill, C; Henry, C; Gillings, S

    2012-09-01

    The purpose of this study was to provide an initial assessment of the potential biologic activity of toceranib phosphate (Palladia®, Pfizer Animal Health, Madison, NJ, USA) in select solid tumours in dogs. Cases in which toceranib was used to treat dogs with apocrine gland anal sac adenocarcinoma (AGASACA), metastatic osteosarcoma (OSA), thyroid carcinoma, head and neck carcinoma and nasal carcinoma were included. Clinical benefit (CB) was observed in 63/85 (74%) dogs including 28/32 AGASACA [8 partial response (PR), 20 stable disease (SD)], 11/23 OSAs (1 PR and 10 SD), 12/15 thyroid carcinomas (4 PR and 8 SD), 7/8 head and neck carcinomas [1 complete response (CR), 5 PR and 1 SD] and 5/7 (1 CR and 4 SD) nasal carcinomas. For dogs experiencing CB, the median dose of toceranib was 2.8 mg kg(-1) , 36/63 (58.7%) were dosed on a Monday/Wednesday/Friday basis and 47/63 (74.6%) were treated 4 months or longer. Although these data provide preliminary evidence that toceranib exhibits CB in dogs with certain solid tumours, future prospective studies are necessary to define its true activity. © 2011 Blackwell Publishing Ltd.

  7. Preliminary Evidence for a Virial Shock around the Coma Galaxy Cluster

    NASA Astrophysics Data System (ADS)

    Keshet, Uri; Kushnir, Doron; Loeb, Abraham; Waxman, Eli

    2017-08-01

    Galaxy clusters, the largest gravitationally bound objects in the universe, are thought to grow by accreting mass from their surroundings through large-scale virial shocks. Due to electron acceleration in such a shock, it should appear as a γ-ray, hard X-ray, and radio ring, elongated toward the large-scale filaments feeding the cluster, coincident with a cutoff in the thermal Sunyaev-Zel’dovich (SZ) signal. However, no such signature was found until now, and the very existence of cluster virial shocks has remained a theory. We find preliminary evidence for a large γ-ray ring of ˜ 5 {Mpc} minor axis around the Coma cluster, elongated toward the large-scale filament connecting Coma and Abell 1367, detected at the nominal 2.7σ confidence level (5.1σ using control signal simulations). The γ-ray ring correlates both with a synchrotron signal and with the SZ cutoff, but not with Galactic tracers. The γ-ray and radio signatures agree with analytic and numerical predictions if the shock deposits ˜ 1 % of the thermal energy in relativistic electrons over a Hubble time and ˜ 1 % in magnetic fields. The implied inverse Compton and synchrotron cumulative emission from similar shocks can contribute significantly to the diffuse extragalactic γ-ray and low-frequency radio backgrounds. Our results, if confirmed, reveal the prolate structure of the hot gas in Coma, the feeding pattern of the cluster, and properties of the surrounding large-scale voids and filaments. The anticipated detection of such shocks around other clusters would provide a powerful new cosmological probe.

  8. Preliminary Base Pressures Obtained from the X-15 Airplane at Mach Numbers from 1.1 to 3.2

    NASA Technical Reports Server (NTRS)

    Saltzman, Edwin J.

    1961-01-01

    Base pressure measurements have been made on the fuselage, 10 deg.-wedge vertical fin, and side fairing of the X-15 airplane. Data are presented for Mach numbers between 1.1 and 3.2 for both powered and unpowered flight. Comparisons are made with data from small-scale-model tests, semiempirical estimates, and theory. The results of this preliminary study show that operation of the interim rocket engines (propellant flow rate approximately 70 lb/sec) reduces the base drag of the X-15 by 25 to 35 percent throughout the test Mach number range. Values of base drag coefficient for the side fairing and fuselage obtained from X-15 wind-tunnel models were adequate for predicting the overall full-scale performance of the test airplane. The leading-edge sweep of the upper movable vertical fin was not an important factor affecting the fin base pressure. The power-off base pressure coefficients of the upper movable vertical fin (a 10 deg. wedge with chord-to-thickness ratio of 5.5 and semispan-to-thickness ratio of 3.2) are in general agreement with the small-scale blunt-trailing-edge-wing data of several investigators and with two-dimensional theory.

  9. Addressing the Evidence Gap in Stroke Rehabilitation for Complex Patients: A Preliminary Research Agenda.

    PubMed

    Nelson, Michelle L; McKellar, Kaileah A; Munce, Sarah; Kelloway, Linda; Hans, Parminder Kaur; Fortin, Martin; Lyons, Renee; Bayley, Mark

    2018-06-01

    Evidence suggests that a stroke occurs in isolation (no comorbid conditions) in less than 6% of patients. Multimorbidity, compounded by psychosocial issues, makes treatment and recovery for stroke increasingly complex. Recent research and health policy documents called for a better understanding of the needs of this patient population, and for the development and testing of models of care that meet their needs. A research agenda specific to complexity is required. The primary objective of the think tank was to identify and prioritize research questions that meet the information needs of stakeholders, and to develop a research agenda specific to stroke rehabilitation and patient complexity. A modified Delphi and World Café approach underpinned the think tank meeting, approaches well recognized to foster interaction, dialogue, and collaboration between stakeholders. Forty-three researchers, clinicians, and policymakers attended a 2-day meeting. Initial question-generating activities resulted in 120 potential research questions. Sixteen high-priority research questions were identified, focusing on predetermined complexity characteristics-multimorbidity, social determinants, patient characteristics, social supports, and system factors. The final questions are presented as a prioritized research framework. An emergent result of this activity is the development of a complexity and stroke rehabilitation research network. The research agenda reflects topics of importance to stakeholders working with stroke patients with increasingly complex care needs. This robust process resulted in a preliminary research agenda that could provide policymakers with the evidence needed to make improvements toward better-organized services, better coordination between settings, improved patient outcomes, and lower system costs. Copyright © 2017 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  10. Predicting Success of Preliminary Surgical Residents: A Multi-Institutional Study.

    PubMed

    Al Fayyadh, Mohammed J; Heller, Stephanie F; Rajab, Taufiek Konrad; Gardner, Aimee K; Bloom, Jordan P; Rawlings, Jeremy A; Mullen, John T; Smink, Douglas S; Farley, David R; Willis, Ross E; Dent, Daniel L

    A nondesignated preliminary surgery (NDPS) position encompasses 1 year of training provided by many general surgery residencies. Our aim was to assess factors predicting success and provide evidence for program directors to support career guidance to preliminary residents. Retrospective cohort study of 221 NDPS residents who entered 5 university-based institutions were identified from 2009 to 2013. Records for trainees were reviewed. We defined primary success as obtaining a categorical position in the specialty of choice and secondary success as obtaining a categorical position in any specialty immediately after finishing their NDPS training. Statistical evaluation was performed using chi-square analysis, independent t-test and logistic regression using α <0.05. Of the 221 NDPS residents, 217 (98%) completed postgraduate year (PGY)-1 and 65 (29%) completed PGY-2. Totally, 90 (41%) obtained categorical general surgery positions, 89 (40%) obtained categorical positions in other specialties, and 42 (19%) failed to obtain a categorical position immediately after their NDPS years. Ultimately, 139 (63%) of residents achieved primary success and 40 (18%) additional residents obtained categorical positions in specialties other than their first choice, resulting in a total of 179 (81%) of residents obtaining categorical positions. Mean United States Medical Licensing Examination step 1 and step 2 scores for those who obtained secondary success were 227 and 234 vs. 214 and 219, respectively, for those who failed to secure a categorical position (p < 0.01). United States Medical Licensing Examination step 2 score was a significant predictor of primary (p < 0.03) and secondary success (p < 0.02). Of 65 PGY-2 NDPS residents, 32 (49%) achieved primary success, and 11 (17%) others achieved secondary success for a total of 43 (66%). For PGY-2 NDPS, American Board of Surgery In-Training Examination was the only significant predictor of primary and secondary success (p < 0.02 and

  11. Preliminary evidence for a unique role of disgust-based conditioning in posttraumatic stress.

    PubMed

    Badour, Christal L; Feldner, Matthew T; Blumenthal, Heidemarie; Knapp, Ashley

    2013-04-01

    Independent lines of evidence have linked posttraumatic stress symptomatology to both peritraumatic disgust (i.e., disgust experienced during a traumatic event) and posttraumatic disgust reactivity in response to traumatic event cues among individuals exposed to traumatic events. Much of this work suggests disgust, defined as a rejection/revulsion response aimed at distancing oneself from a potential source of contamination, may be important in understanding the nature of posttraumatic stress reactions even after accounting for the more frequently studied affective states of fear and anxiety. The current investigation provided a preliminary test of a model of disgust in posttraumatic stress among a sample of 54 community-recruited women with a history sexual victimization. Both peritraumatic disgust (r = .31) and posttraumatic disgust reactivity (r = .42) in response to an idiographic traumatic event script were significantly associated with posttraumatic stress symptom severity. After accounting for variability-associated peritraumatic fear and posttraumatic anxious reactivity, an indirect effect of peritraumatic disgust through posttraumatic disgust reactivity also was found, suggesting that one mechanism through which peritraumatic disgust relates to posttraumatic stress is through its relation with increased posttraumatic disgust reactivity. These findings highlight the importance of further elucidating the nature of disgust in relation to traumatic events and subsequent posttraumatic stress reactions. Copyright © 2013 International Society for Traumatic Stress Studies.

  12. Preliminary longitudinal report on symptom outcomes in symptomatic and asymptomatic women with imaging evidence of temporomandibular joint arthritic changes.

    PubMed

    Schmitter, Marc; Wacker, Katrin; Pritsch, Maria; Giannakopoulos, Nikolas Nikitas; Klose, Christina; Faggion, Clovis; Kress, Bodo; Leckel, Michael; Rammelsberg, Peter

    2010-01-01

    The objectives of this preliminary, longitudinal, and explorative cohort study were to assess changes in and the onset of osteoarthrosis (OA)-related pain in the temporomandibular joint (TMJ) and to address factors that might impact the development or reduction of associated pain symptoms. In this sex-matched study, 60 women were recruited (30 asymptomatic with a magnetic resonance imaging [MRI] diagnosis of OA-related TMJ changes, 30 symptomatic with accompanying MRI evidence of OA of the TMJ). All subjects underwent a baseline clinical examination and MRI assessment and were subsequently referred to a dental practitioner, who was informed of the diagnosis and further treatment where required. Not all subjects underwent dental treatment interventions. Following a mean 4-year period, subjects were reexamined clinically. Spearman rank correlation and Mann-Whitney U tests were used to evaluate possible correlations in reported pain level changes with the number of posterior occlusal contacts and new dental restorations placed between baseline and recall appointments. The dropout rate was 28% (6.7% for symptomatic, 50% for asymptomatic). OA-related TMJ pain in symptomatic subjects decreased with time (pain reduction: ?3.6 ± 3.4 on a 0 to 10 numeric rating scale); asymptomatic patients rarely developed pain. These preliminary results suggest that factors other than dental occlusion might play a role in the reduction of pain.

  13. Preliminary assessment of appropriateness of emergency care service use: actions taken and consultations obtained before emergency care presentation.

    PubMed

    Tzeng, Huey-Ming

    2011-01-01

    Inappropriate use of emergency care services can increase hospital readmissions and related costs. This pilot, cross-sectional survey project determined whether home health care patients who receive emergency care services during a Medicare-approved home care episode sought consultation from health care professionals before they made the emergency care visit. The two research questions were: (a) What actions were taken by the patient before making an emergency care visit?; (b) If prior consultation was obtained, what were the suggestions? Preliminary data were obtained from a Michigan-based, Medicare-certified, not-for-profit home health agency affiliated with a university health system. A two-page questionnaire recorded up to three emergency care visits. Volunteer participants were Medicare patients who had no cognitive deficits and were able to communicate with home health care providers (HHCPs) by themselves. Thirty-five emergency care visits were reported; 31 (88.6%) Medicare patients participated and 4 (11.4%) of them had two emergency care visits. Before the patients made an emergency care visit, they most often called their primary care physicians (PCPs; N = 20, 57.1%), followed by the HHCPs (N = 10, 28.6%). All 20 patients who contacted their PCPs and 7 patients who contacted their HHCPs were advised to seek emergency care services. In 20 emergency care visits the patient was admitted for an acute hospital stay; the other 15 patients went home. Most patients contacted their PCPs or HHCPs before they went to an emergency department or urgent care facility. These results implied that PCPs and HHCPs seemed to perceive that the need for emergency care should be determined at an emergency room or urgent care facility. This study was unable to differentiate the need for emergency care services or the appropriateness of the advice given by PCPs or HHCPs when the home care patients were under the care of a medical team.

  14. Financial decision-making abilities and financial exploitation in older African Americans: Preliminary validity evidence for the Lichtenberg Financial Decision Rating Scale (LFDRS).

    PubMed

    Lichtenberg, Peter A; Ficker, Lisa J; Rahman-Filipiak, Annalise

    2016-01-01

    This study examines preliminary evidence for the Lichtenberg Financial Decision Rating Scale (LFDRS), a new person-centered approach to assessing capacity to make financial decisions, and its relationship to self-reported cases of financial exploitation in 69 older African Americans. More than one third of individuals reporting financial exploitation also had questionable decisional abilities. Overall, decisional ability score and current decision total were significantly associated with cognitive screening test and financial ability scores, demonstrating good criterion validity. Study findings suggest that impaired decisional abilities may render older adults more vulnerable to financial exploitation, and that the LFDRS is a valid tool.

  15. Experimental evidence for a new single-event upset (SEU) mode in a CMOS SRAM obtained from model verification

    NASA Technical Reports Server (NTRS)

    Zoutendyk, J. A.; Smith, L. S.; Soli, G. A.; Lo, R. Y.

    1987-01-01

    Modeling of SEU has been done in a CMOS static RAM containing 1-micron-channel-length transistors fabricated from a p-well epilayer process using both circuit-simulation and numerical-simulation techniques. The modeling results have been experimentally verified with the aid of heavy-ion beams obtained from a three-stage tandem van de Graaff accelerator. Experimental evidence for a novel SEU mode in an ON n-channel device is presented.

  16. Sex-related functional asymmetry of the amygdala: preliminary evidence using a case-matched lesion approach.

    PubMed

    Tranel, Daniel; Bechara, Antoine

    2009-06-01

    We have reported previously that there appears to be an intriguing sex-related functional asymmetry of the prefrontal cortices, especially the ventromedial sector, in regard to social conduct, emotional processing, and decision-making, whereby the right-sided sector is important in men but not women and the left-sided sector is important in women but not men. The amygdala is another structure that has been widely implicated in emotion processing and social decision-making, and the question arises as to whether the amygdala, in a manner akin to what has been observed for the prefrontal cortex, might have sex-related functional asymmetry in regard to social and emotional functions. A preliminary test of this question was carried out in the current study, where we used a case-matched lesion approach and contrasted a pair of men cases and a pair of women cases, where in each pair one patient had left amygdala damage and the other had right amygdala damage. We investigated the domains of social conduct, emotional processing and personality, and decision-making. The results provide support for the notion that there is sex-related functional asymmetry of the amygdala in regard to these functions - in the male pair, the patient with right-sided amygdala damage was impaired in these functions, and the patient with left-sided amygdala damage was not, whereas in the female pair, the opposite pattern obtained, with the left-sided woman being impaired and the right-sided woman being unimpaired. These data provide preliminary support for the notion that sex-related functional asymmetry of the amygdala may entail functions such as social conduct, emotional processing, and decision-making, a finding that in turn could reflect (as either a cause or effect) differences in the manner in which men and women apprehend, process, and execute emotion-related information.

  17. Physical Feature Encoding and Word Recognition Abilities Are Altered in Children with Intractable Epilepsy: Preliminary Neuromagnetic Evidence

    PubMed Central

    Pardos, Maria; Korostenskaja, Milena; Xiang, Jing; Fujiwara, Hisako; Lee, Ki H.; Horn, Paul S.; Byars, Anna; Vannest, Jennifer; Wang, Yingying; Hemasilpin, Nat; Rose, Douglas F.

    2015-01-01

    Objective evaluation of language function is critical for children with intractable epilepsy under consideration for epilepsy surgery. The purpose of this preliminary study was to evaluate word recognition in children with intractable epilepsy by using magnetoencephalography (MEG). Ten children with intractable epilepsy (M/F 6/4, mean ± SD 13.4 ± 2.2 years) were matched on age and sex to healthy controls. Common nouns were presented simultaneously from visual and auditory sensory inputs in “match” and “mismatch” conditions. Neuromagnetic responses M1, M2, M3, M4, and M5 with latencies of ~100 ms, ~150 ms, ~250 ms, ~350 ms, and ~450 ms, respectively, elicited during the “match” condition were identified. Compared to healthy children, epilepsy patients had both significantly delayed latency of the M1 and reduced amplitudes of M3 and M5 responses. These results provide neurophysiologic evidence of altered word recognition in children with intractable epilepsy. PMID:26146459

  18. Comparison of acoustic therapies for tinnitus suppression: a preliminary trial.

    PubMed

    Schad, Maggie L; McMillan, Garnett P; Thielman, Emily J; Groon, Katherine; Morse-Fortier, Charlotte; Martin, Jennifer L; Henry, James A

    2018-02-01

    This study obtained preliminary data using two types of sound therapy to suppress tinnitus and/or reduce its functional effects: (1) Notched noise (1000-12,000 Hz notched within a 1-octave range centred around the tinnitus pitch match [PM] frequency); and (2) Matched noise (1-octave wide band of noise centred around the PM frequency). A third (Placebo) group listened to low frequency noise (250-700 Hz). Participants with bothersome tinnitus were randomised into one of the three groups and instructed to listen to the acoustic stimulus for 6 hours a day for 2 weeks. Stimuli were delivered using an iPod Nano, and tinnitus counselling was not performed. Outcome measures were recorded at the 0, 2 and 4 week study visits. Thirty participants with constant and bothersome tinnitus were recruited and randomised. All groups showed, on average, overall improvement, both immediately post-treatment and 2 weeks following treatment. Outcomes varied between groups on the different measures and at the two outcome points. This study showed improvement for all of the groups, lending support to the premise that any type of sound stimulation is beneficial for relieving effects of tinnitus. These results may serve as a preliminary evidence for a larger study.

  19. Preliminary Analysis of Fluctuations in the Received Uplink-Beacon-Power Data Obtained From the GOLD Experiments

    NASA Technical Reports Server (NTRS)

    Jeganathan, M.; Wilson, K. E.; Lesh, J. R.

    1996-01-01

    Uplink data from recent free-space optical communication experiments carried out between the Table Mountain Facility and the Japanese Engineering Test Satellite are used to study fluctuations caused by beam propagation through the atmosphere. The influence of atmospheric scintillation, beam wander and jitter, and multiple uplink beams on the statistics of power received by the satellite is analyzed and compared to experimental data. Preliminary analysis indicates the received signal obeys an approximate lognormal distribution, as predicted by the weak-turbulence model, but further characterization of other sources of fluctuations is necessary for accurate link predictions.

  20. Preliminary analysis of fluctuations in the received uplink-beacon-power data obtained from the GOLD experiments

    NASA Technical Reports Server (NTRS)

    Jeganathan, M.; Wilson, K. E.; Lesh, J. R.

    1996-01-01

    Uplink data from recent free-space optical communication experiments carried out between the Table Mountain Facility and the Japanese Engineering Test Satellite are used to study fluctuations caused by beam propagation through the atmosphere. The influence of atmospheric scintillation, beam wander and jitter, and multiple uplink beams on the statistics of power received by the satellite is analyzed and compared to experimental data. Preliminary analysis indicates the received signal obeys an approximate lognormal distribution, as predicted by the weak-turbulence model, but further characterization of other sources of fluctuations is necessary for accurate link predictions.

  1. Preliminary evidence that sub-chronic citalopram triggers the re-evaluation of value in intimate partnerships

    PubMed Central

    Bilderbeck, Amy C.; Wakeley, Judi; Godlewska, Beata R.; McGlone, Francis; Harris, Tirril; Cowen, Phillip J.

    2014-01-01

    Depression frequently involves disrupted inter-personal relationships, while treatment with serotonergic anti-depressants can interfere with libido and sexual function. However, little is known about how serotonin activity influences appraisals of intimate partnerships. Learning more could help to specify how serotonergic mechanisms mediate social isolation in psychiatric illness. Forty-four healthy heterosexual adults, currently in romantic relationships, received 8 days treatment with the selective serotonin re-uptake inhibitor citalopram (N = 21; 10 male) or placebo (N = 23; 12 male). Participants viewed photographs of unknown, heterosexual couples and made a series of judgements about their relationships. Participants also indicated the importance of relationship features in their own close partnerships, and close partnerships generally. Citalopram reduced the rated quality of couples’ physical relationships and the importance attributed to physical and intimate aspects of participants’ own relationships. In contrast, citalopram also enhanced the evaluated worth of mutual trust in relationships. Amongst males, citalopram was associated with judgements of reduced turbulence and bickering in others’ relationships, and increased male dominance. These data constitute preliminary evidence that enhancing serotonin activity modulates cognitions about sexual activity as part of a re-appraisal of sources of value within close intimate relationships, enhancing the judged importance of longer-term benefits of trust and shared experiences. PMID:23996287

  2. The professional clothing bank as evidence-based practice.

    PubMed

    Bishop, SueZanne Monique

    2015-01-01

    Little research exists linking interview-appropriate attire to improved employment outcomes for women. Thus, it appears that the professional clothing bank has not been investigated as evidence-based practice. To provide preliminary evidence for clothing banks, in this article the author synthesizes findings from existing research on the provision of a professional clothing bank as a means for offering interview-appropriate attire to poor women in job readiness programming. For context, job readiness programs are explored and a case study of one program operating a professional clothing bank is presented. Finally, preliminary considerations for planning and implementing clothing banks based on this literature review are given.

  3. A new Arctic seepage site? Preliminary evidence from benthic community

    NASA Astrophysics Data System (ADS)

    Caridi, Francesca; Sabbatini, Anna; Morigi, Caterina; Giulia Lucchi, Renata

    2017-04-01

    The Kveithola Trough is an abrupt and narrow sedimentary system located in the NW Barents Sea. The hydrographic, bio-geochemical conditions and the possible existence of gas seepage activity of the area have been investigated during the Eurofleets 2- BURSTER cruise, conducted on board the German icebreaker RV Polarstern. The aim of our work is to characterize the benthic biota and more specifically the macrofaunal community structure coupled to the study of benthic foraminiferal meiofauna. Preliminary qualitative results revealed that in the inner Kveithola Trough, the macrofaunal community is composed by abundant black worm tubes (Chaetopteridae worms and Siboglinidae-like taxa) with presence of Thyasiridae bivalve species. The occurrence of these macrofaunal taxa is usually associated to oxygen-reduced environments, hydrothermal vents and cold seeps. The living benthic foraminiferal assemblage in the same stations is characterized by the presence of typically oxygen-depleted environmental taxa including the calcareous species Nonionellina labradorica and Globobulimina spp.. Conversely, in the outer Kveithola trough, both benthic macrofauna and foraminiferal meiofauna assemblages are characterized by less opportunistic taxa with a higher biodiversity suggesting very distinct oceanographic sea bottom conditions. The organic matter richness plays a large role in the Kveithola Trough environmental setting and may bring anoxic conditions that could affect the biota of the area. In fact, the benthic community structure of this area inhabits suboxic, anoxic and organic-enriched sediments and disturbed environments, forming assemblages with low diversity and high abundances of a few tolerant and/or specialized species. This preliminary finding could be consistent with other studies examining benthic community structure around Svalbard and in particular cold seep and vents habitats where faunal characteristics are patchy, suggesting small-scale heterogeneity in the

  4. Dual-fuel, dual-throat engine preliminary analysis

    NASA Technical Reports Server (NTRS)

    Obrien, C. J.

    1979-01-01

    A propulsion system analysis of the dual fuel, dual throat engine for launch vehicle applications was conducted. Basic dual throat engine characterization data were obtained to allow vehicle optimization studies to be conducted. A preliminary baseline engine system was defined.

  5. Reliability and preliminary evidence of validity of a Farsi version of the depression anxiety stress scales.

    PubMed

    Bayani, Ali Asghar

    2010-08-01

    The internal consistency, test-retest reliability, and construct validity of the Farsi version of the Depression Anxiety Stress Scales were examined, with a sample of 306 undergraduate students (123 men, 183 women) ranging from 18 to 51 years of age (M age = 25.4, SD = 6.1). Participants completed the Satisfaction with Life Scale, Rosenberg Self-esteem Scale, and the Depression Anxiety Stress Scales. The findings confirmed the preliminary reliabilities and preliminary construct validity of the Farsi translation of the Depression Anxiety Stress Scales.

  6. Preliminary results on heavy flavor physics at SLD

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Usher, T.

    1994-12-01

    The author reports on preliminary heavy flavor physics results from the SLD detector at the SLAC Linear Collider. Efficient tagging of b{bar b} events is achieved with an impact parameter technique that takes advantage of the small and stable interaction point of the SLC and all charged tracks in Z{sup 0} decays. This technique is applied to samples of Z{sup 0} events collected during the 1992 and 1993 physics runs. Preliminary measurements of the ratio R{sub b} = {Gamma}(Z{sup 0} {yields} b{bar b})/{Gamma}(Z{sup 0} {yields} hadrons) and the average B hadron lifetime <{tau}{sub B}> are reported. In a sample ofmore » 27K Z{sup 0} events, values of R{sub b} = 0.235 {+-} 0.006(stat.) {+-} 0.018(syst.) and <{tau}{sub B}> = 1.53 {+-} 0.006(stat.) {+-} 0.018(syst.) are obtained. In addition, the first measurement of the left-right asymmetry A{sub b} is reported. Using a sample of 38K Z{sup 0} events with a luminosity weighted electron polarization of 62%, the author obtains a preliminary value of A{sub b} = 0.94 {+-} 0.006(stat.) {+-} 0.018(syst.).« less

  7. Criminalystic: effectiveness of lysochromes on the developing of invisible lipstick-contaminated lipmarks on human skin. A preliminary study.

    PubMed

    Navarro, Esperanza; Castelló, Ana; López, Jose L; Verdú, Fernando

    2006-04-20

    Latent prints are an important evidence for identification. Nowadays, the technical means, the implementation of image processing techniques and the use of database makes it possible to detect and get information from some prints that seem to be useless at first sight. On the other hand, the possibility of using the print as a DNA source has to be considered, so as to double its identifying value. Human skin is a particularly difficult surface for developing this kind of evidences. Although different methods for locating and developing latent fingerprints on the skin have been already described, it has not been found any method, at the revised bibliography, to obtain and develop invisible lipmarks, that is, lipmarks from protective lipstick, or permanent or long-lasting lipstick. The aim of the work that follows is to determine the effectiveness of several reagents for developing invisible lipmarks on the corpses' skin. Preliminary results show that, under the described experimental conditions, the reagents used, Sudan III, Oil Red O and Sudan Black, are effective for obtaining recent latent lip prints on corpse's skin.

  8. Conversational evidence in therapeutic dialogue.

    PubMed

    Strong, Tom; Busch, Robbie; Couture, Shari

    2008-07-01

    Family therapists' participation in therapeutic dialogue with clients is typically informed by evidence of how such dialogue is developing. In this article, we propose that conversational evidence, the kind that can be empirically analyzed using discourse analyses, be considered a contribution to widening psychotherapy's evidence base. After some preliminaries about what we mean by conversational evidence, we provide a genealogy of evaluative practice in psychotherapy, and examine qualitative evaluation methods for their theoretical compatibilities with social constructionist approaches to family therapy. We then move on to examine the notion of accomplishment in therapeutic dialogue given how such accomplishments can be evaluated using conversation analysis. We conclude by considering a number of research and pedagogical implications we associate with conversational evidence.

  9. Preliminary evidence that sub-chronic citalopram triggers the re-evaluation of value in intimate partnerships.

    PubMed

    Bilderbeck, Amy C; Wakeley, Judi; Godlewska, Beata R; McGlone, Francis; Harris, Tirril; Cowen, Phillip J; Rogers, Robert D

    2014-09-01

    Depression frequently involves disrupted inter-personal relationships, while treatment with serotonergic anti-depressants can interfere with libido and sexual function. However, little is known about how serotonin activity influences appraisals of intimate partnerships. Learning more could help to specify how serotonergic mechanisms mediate social isolation in psychiatric illness. Forty-four healthy heterosexual adults, currently in romantic relationships, received 8 days treatment with the selective serotonin re-uptake inhibitor citalopram (N = 21; 10 male) or placebo (N = 23; 12 male). Participants viewed photographs of unknown, heterosexual couples and made a series of judgements about their relationships. Participants also indicated the importance of relationship features in their own close partnerships, and close partnerships generally. Citalopram reduced the rated quality of couples' physical relationships and the importance attributed to physical and intimate aspects of participants' own relationships. In contrast, citalopram also enhanced the evaluated worth of mutual trust in relationships. Amongst males, citalopram was associated with judgements of reduced turbulence and bickering in others' relationships, and increased male dominance. These data constitute preliminary evidence that enhancing serotonin activity modulates cognitions about sexual activity as part of a re-appraisal of sources of value within close intimate relationships, enhancing the judged importance of longer-term benefits of trust and shared experiences. © The Author (2013). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

  10. Porous titanium obtained by a new powder metallurgy technique: Preliminary results of human osteoblast adhesion on surface polished substrates.

    PubMed

    Biasotto, M; Ricceri, R; Scuor, N; Schmid, C; Sandrucci, M A; Di Lenarda, R; Matteazzi, P

    2003-01-01

    This study concerns a novel powder metallurgy method for producing porous titanium (pTi) exhibiting high mechanical properties. The preparation procedure consisted of the following stages: first, the preparation of Ti and titanium hydride (TiH2) powder mixtures and their consolidation with a cold isostatic press, followed by a sintering of the green bodies performed with hot isostatic press (HIP) equipment. Thermal decomposition in controlled environment of the TiH2 phase results in the foam structure. The resulting porosity percolates with a volume fraction of approximately 20%. The final material exhibits interesting mechanical properties, comparable to those of full density titanium (between grade 2 and grade 3), with the advantage of a minor density. The samples produced were tested to verify their biological response by studying the effectiveness of osteoblast adhesion and growth. In this preliminary study, osteoblastic cell morphology was investigated and compared to that observed on fully dense commercially pure titanium (Ti-cp) (ASTM, grade 3). The preliminary results were promising regarding cellular adhesion and spreading. (Journal of Applied Biomaterials & Biomechanics 2003; 1: 172-7).

  11. Social Resistance Framework for Understanding High-Risk Behavior Among Nondominant Minorities: Preliminary Evidence

    PubMed Central

    Williams, David R.; Kawachi, Ichiro

    2013-01-01

    Objectives. The recently developed social resistance framework addresses a widespread pattern in which members of some nondominant minorities tend to engage in various risky and unhealthy behaviors more than the majority group. This pilot study tested the core hypotheses derived from this innovative framework. Methods. We conducted in 2011 a nationally representative Web-based survey of 200 members of a nondominant minority group (African Americans) and 200 members of a majority group (Whites). Results. The preliminary findings supported the main premises of the framework and suggested that nondominant minorities who felt discriminated and alienated from society tended also to have higher levels of social resistance. Those with higher levels of social resistance also engaged more in risky and unhealthy behaviors—smoking, drinking, and nonuse of seat belts—than did those with lower levels of social resistance. These associations were not found in the majority group. Conclusions. These preliminary results supported the framework and suggested that social resistance might play a meaningful role in risky and unhealthy behaviors of nondominant minorities, and should be taken into account when trying to reduce health disparities. PMID:23597381

  12. Preliminary Study of a Piston Pump for Cryogenic Fluids

    NASA Technical Reports Server (NTRS)

    Biermann, Arnold E.; Kohl, Robert C.

    1959-01-01

    Preliminary data are presented covering the performance of a low-speed, five-cylinder piston pump designed for handling boiling hydrogen. This pump was designed for a flow of 55 gallons per minute at 240 rpm with a discharge pressure of 135 pounds per square inch. Tests were made using JP-4 fuel, liquid nitrogen, and liquid hydrogen. Pump delivery and endurance characteristics were satisfactory for the range of operation covered. In connection with the foregoing pump development, the cavitation characteristics of a preliminary visual model, glass-cylinder pump and of a simple reciprocating disk were studied. Subcooling of approximately 0.60 F was obtained from the cavitation produced by reciprocating a disk in boiling nitrogen and in boiling water. The subcooling obtained in a similar manner with liquid hydrogen was somewhat less.

  13. Association Between Initial Age of Exposure to Childhood Abuse and Cognitive Control: Preliminary Evidence.

    PubMed

    Mackiewicz Seghete, Kristen L; DePrince, Anne P; Banich, Marie T

    2018-05-22

    Cognitive control, which relies on the protracted development of frontal-parietal regions into adolescence, is a brain process that may be particularly vulnerable to the impact of childhood abuse. In this study, we used functional magnetic resonance imaging (fMRI) to examine associations between the age of onset of childhood abuse and alterations to the neural mechanisms supporting cognitive control in early adulthood, which have not been previously examined. During fMRI scanning, participants completed hybrid block/event-related versions of a classic color-word Stroop task as well as emotional Stroop tasks (threat and positive words). Participants were young adult women (N = 15; age range: 23-30 years) who had a history of childhood physical or sexual abuse that began prior to 13 years of age. Results indicated that earlier age of onset of childhood abuse was robustly associated with increased transient (i.e., event-related) recruitment of medial cognitive control regions in the classic color-word paradigm as well as with less suppression of medial frontal regions that are part of the default mode network, βs = -.16 to -.87. In comparison, increased activation in dorsolateral prefrontal regions was associated with earlier age of abuse onset under conditions of sustained (i.e., blocked) cognitive control in the emotional Stroop task for blocks of positive distracting words versus fixation, βs = -.50 to -.60. These results provide preliminary evidence that earlier age of exposure to childhood abuse impacts the functional activation of neural systems involved in cognitive control in adulthood. Copyright © 2018 International Society for Traumatic Stress Studies.

  14. Hypoallergenic properties of donkey's milk: a preliminary study.

    PubMed

    Vincenzetti, Silvia; Foghini, Laura; Pucciarelli, Stefania; Polzonetti, Valeria; Cammertoni, Natalina; Beghelli, Daniela; Polidori, Paolo

    2014-01-01

    Cow's milk protein allergy (CMPA) is an abnormal immunological response to cow milk proteins, which results in IgE-mediated reactions. The therapeutic strategy to respond to CMPA envisages the total elimination of milk or the administration of cow's milk substitutes. For this reason the use of milk from other mammalian species was tested. Among them, donkey's milk proved to be the best alternative in feeding infants affected by CMPA, since its chemical composition is comparable to human milk. In this work an in vitrostudy was performed in order to analyze the IgE reactivity to milk protein allergens from cow, donkey and goat. In particular, immunoblotting experiments using sera from milk-allergic and non-allergic adult volunteers were conducted with the aim of verifying the hypoallergenic property of donkey's milk. This study provided a preliminary evidence of the hypoallergenicity of donkey's milk when compared to bovine and goat milk. Considering the obtained results, it would be possible to develop a sensitive diagnostic method for CMPA detection, based on chromatographic and immunoblotting analysis.

  15. Preliminary Analysis of the BASALA-H Experimental Programme

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Blaise, Patrick; Fougeras, Philippe; Philibert, Herve

    2002-07-01

    This paper is focused on the preliminary analysis of results obtained on the first cores of the first phase of the BASALA (Boiling water reactor Advanced core physics Study Aimed at mox fuel Lattice) programme, aimed at studying the neutronic parameters in ABWR core in hot conditions, currently under investigation in the French EOLE critical facility, within the framework of a cooperation between NUPEC, CEA and Cogema. The first 'on-line' analysis of the results has been made, using a new preliminary design and safety scheme based on the French APOLLO-2 code in its 2.4 qualified version and associated CEA-93 V4more » (JEF-2.2) Library, that will enable the Experimental Physics Division (SPEx) to perform future core designs. It describes the scheme adopted and the results obtained in various cases, going to the critical size determination to the reactivity worth of the perturbed configurations (voided, over-moderated, and poisoned with Gd{sub 2}O{sub 3}-UO{sub 2} pins). A preliminary study on the experimental results on the MISTRAL-4 is resumed, and the comparison of APOLLO-2 versus MCNP-4C calculations on these cores is made. The results obtained show very good agreements between the two codes, and versus the experiment. This work opens the way to the future full analysis of the experimental results of the qualifying teams with completely validated schemes, based on the new 2.5 version of the APOLLO-2 code. (authors)« less

  16. Development of volume equations using data obtained by upper stem dendrometry with Monte Carlo integration: preliminary results for eastern redcedar

    Treesearch

    Thomas B. Lynch; Rodney E. Will; Rider Reynolds

    2013-01-01

    Preliminary results are given for development of an eastern redcedar (Juniperus virginiana) cubic-volume equation based on measurements of redcedar sample tree stem volume using dendrometry with Monte Carlo integration. Monte Carlo integration techniques can be used to provide unbiased estimates of stem cubic-foot volume based on upper stem diameter...

  17. Preliminary Evidence for an Emerging Nonmetropolitan Mortality Penalty in the United States

    PubMed Central

    Cosby, Arthur G.; Neaves, Tonya T.; Cossman, Ronald E.; Cossman, Jeralynn S.; James, Wesley L.; Feierabend, Neal; Mirvis, David M.; Jones, Carol A.; Farrigan, Tracey

    2008-01-01

    We discovered an emerging non-metropolitan mortality penalty by contrasting 37 years of age-adjusted mortality rates for metropolitan versus nonmetropolitan US counties. During the 1980s, annual metropolitan–nonmetropolitan differences averaged 6.2 excess deaths per 100000 nonmetropolitan population, or approximately 3600 excess deaths; however, by 2000 to 2004, the difference had increased more than 10 times to average 71.7 excess deaths, or approximately 35 000 excess deaths. We recommend that research be undertaken to evaluate and utilize our preliminary findings of an emerging US nonmetropolitan mortality penalty. PMID:18556611

  18. Preliminary measurements of 135Cs with AMS

    NASA Astrophysics Data System (ADS)

    Yin, Xinyi; He, Ming; Dong, Kejun; Dou, Liang; Lan, Xiaoxi; Pang, Fangfang; Wu, Shaoyong; Jiang, Shan

    2015-10-01

    135Cs is an interesting nuclide in many research fields, especially in environmental study. Preliminary measurements of the long-lived 135Cs with accelerator mass spectrometry (AMS) have been developed with the HI-13 tandem AMS facility at China Institute of Atomic Energy (CIAE). In order to improve ion extracting current and depressing background interference, experiments were carried out on different ions of Cs extracted from different samples. It was found that Cs- extracted from CsNO3 can be used for AMS measurement of 135Cs. According to the preliminary results, the background level can be obtained with blanks was 135Ba/Cs ∼ 8.8 × 10-12 with the CIAE-AMS system.

  19. Preliminary evidence for deficits in multisensory integration in autism spectrum disorders: the mirror neuron hypothesis.

    PubMed

    Oberman, Lindsay M; Ramachandran, Vilayanur S

    2008-01-01

    Autism is a complex disorder, characterized by social, cognitive, communicative, and motor symptoms. One suggestion, proposed in the current study, to explain the spectrum of symptoms is an underlying impairment in multisensory integration (MSI) systems such as a mirror neuron-like system. The mirror neuron system, thought to play a critical role in skills such as imitation, empathy, and language can be thought of as a multisensory system, converting sensory stimuli into motor representations. Consistent with this, we report preliminary evidence for deficits in a task thought to tap into MSI--"the bouba-kiki task" in children with ASD. The bouba-kiki effect is produced when subjects are asked to pair nonsense shapes with nonsense "words". We found that neurotypical children chose the nonsense "word" whose phonemic structure corresponded with the visual shape of the stimuli 88% of the time. This is presumably because of mirror neuron-like multisensory systems that integrate the visual shape with the corresponding motor gestures used to pronounce the nonsense word. Surprisingly, individuals with ASD only chose the corresponding name 56% of the time. The poor performance by the ASD group on this task suggests a deficit in MSI, perhaps related to impaired MSI brain systems. Though this is a behavioral study, it provides a testable hypothesis for the communication impairments in children with ASD that implicates a specific neural system and fits well with the current findings suggesting an impairment in the mirror systems in individuals with ASD.

  20. Causal role for inverse reasoning on obsessive-compulsive symptoms: Preliminary evidence from a cognitive bias modification for interpretation bias study.

    PubMed

    Wong, Shiu F; Grisham, Jessica R

    2017-12-01

    The inference-based approach (IBA) is a cognitive account of the genesis and maintenance of obsessive-compulsive disorder (OCD). According to the IBA, individuals with OCD are prone to using inverse reasoning, in which hypothetical causes form the basis of conclusions about reality. Several studies have provided preliminary support for an association between features of the IBA and OCD symptoms. However, there are currently no studies that have investigated the proposed causal relationship of inverse reasoning in OCD. In a non-clinical sample (N = 187), we used an interpretive cognitive bias procedure to train a bias towards using inverse reasoning (n = 64), healthy sensory-based reasoning (n = 65), or a control condition (n = 58). Participants were randomly allocated to these training conditions. This manipulation allowed us to assess whether, consistent with the IBA, inverse reasoning training increased compulsive-like behaviours and self-reported OCD symptoms. Results indicated that compared to a control condition, participants trained in inverse reasoning reported more OCD symptoms and were more avoidant of potentially contaminated objects. Moreover, change in inverse reasoning bias was a small but significant mediator of the relationship between training condition and behavioural avoidance. Conversely, training in a healthy (non-inverse) reasoning style did not have any effect on symptoms or behaviour relative to the control condition. As this study was conducted in a non-clinical sample, we were unable to generalise our findings to a clinical population. Findings generally support the IBA model by providing preliminary evidence of a causal role for inverse reasoning in OCD. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Preliminary evidence of attenuated blood pressure reactivity to acute stress in adults following a recent marital separation.

    PubMed

    Grinberg, Austin M; O'Hara, Karey L; Sbarra, David A

    2018-03-01

    This study explores cardiovascular reactivity during an acute-stress task in a sample of recently separated adults. In a cross-sectional design, we examined the association between adults' subjective separation-related distress and changes in heart rate and blood pressure across the acute-stress laboratory paradigm in a sample of 133 (n = 49 men) recently separated adults. Heart rate (HR) and Blood pressure (BP) were recorded across a resting baseline period, a math stressor task, and a recovery period. Multilevel analyses revealed that adults who reported greater separation-related distress exhibited higher initial BP and a slower linear increase in BP across the study period. In addition, adults reporting greater separation-related distress evidenced significantly slower declines in diastolic blood pressure (DBP) following the acute-stress task. HR reactivity was not moderated by separation-related distress. In recently separated adults, preliminary evidence suggests that the context of the stressors may reveal differential patterns of problematic reactivity (exaggerated or blunted responding). Greater emotional intrusion and hyperactivity symptoms may index increased risk for blunted cardiovascular reactivity to general stressors. This pattern of reactivity is consistent with models of allostatic load that emphasise the deleterious effect of hyporesponsivity to environmental demands.

  2. A Preliminary Teleseismic Investigation of the Crust and Mantle Lithosphere Obtained from BISN in the Western Canadian Arctic

    NASA Astrophysics Data System (ADS)

    Schaeffer, A. J.; Snyder, D. B.; Cairns, S.; Elliot, B.; Audet, P.; Esteve, C.; Murray-Bergquist, L.; Falck, H.

    2016-12-01

    The tectonic evolution of the Beaufort Sea continental margin has contributed to the maturation of these rocks into a major petroleum reservoir. Recent shallow offshore seismic reflection data suggest that Banks Island represents thin crust along a rifted margin established during the opening of the Arctic Ocean. In this case, rifting of the margin caused Banks Island to subside and accumulate sediments rich in petroleum source material. The cooling history and further subsidence of these sediments is important for understanding the thermal maturation of petroleum products. Recently published surface-wave velocity models of North America indicate seismic velocities at 100-150 km depths similar to those beneath Canada's diamond mines in the central Slave craton north of Yellowknife. These results imply that Banks Island is part of the Canadian Shield and that any kimberlites found thereon might contain diamonds. However, the fast velocities are inconsistent with this being a tectonically disrupted and thinned lithosphere along the Arctic margin of the Canada Basin. The problem is therefore to reconcile mantle structure typical of the Canadian Shield with crust typical of a rifted passive margin. Possibly related seismicity beneath the Mackenize River Delta and offshore in the Beaufort Sea has been observed for decades but its origin remains unknown, although has been suggested as due to incipient subduction of oceanic lithosphere beneath the North American craton. Resolving these questions requires high-resolution 3-D seismic models obtained from an array of broadband seismograph stations. Here we present preliminary results on the structure of the crust and uppermost mantle underlying the western Canadian Arctic. These results are generated using new data from the Banks Island Seismograph Network (BISN), three stations installed over the summer of 2014 and 2015; augmented with several USArray Transportable Array stations and older POLARIS and CNSN stations on

  3. Randomized controlled trial of a web-based indoor tanning intervention: Acceptability and preliminary outcomes.

    PubMed

    Stapleton, Jerod L; Manne, Sharon L; Darabos, Katie; Greene, Kathryn; Ray, Anne E; Turner, Amber L; Coups, Elliot J

    2015-12-01

    This article describes the acceptability and preliminary behavioral outcomes of a pilot randomized control trial of a web-based indoor tanning intervention for young adult women. The intervention targets indoor tanning users' perceptions of the benefits and value of tanning and addresses the role of body image-related constructs in indoor tanning. Participants were 186 young adult women who reported indoor tanning at least once in the past 12 months. The study design was a 2-arm randomized controlled trial with pre- and postintervention assessments and random assignment to an intervention or control condition. Intervention acceptability was assessed by obtaining participants' evaluation of the intervention. Regression analyses were used to test for intervention condition differences in preliminary behavioral outcomes measured at 6 weeks postintervention. Participants provided favorable evaluations of the intervention on several dimensions and a highly positive overall rating. Intervention participants were more likely to report abstaining from indoor tanning and indicated a lower likelihood of using indoor tanning in the future compared with control participants on the postintervention assessment. No differences were found for sunburns. The results of this pilot randomized controlled trial provide evidence that the indoor tanning intervention is acceptable to participants and may encourage cessation of indoor tanning behavior. The findings provide preliminary support for an indoor tanning intervention that engages tanners to challenge their beliefs about the benefits of indoor tanning. The use of a web-based indoor tanning intervention is unique and provides strong potential for dissemination. (PsycINFO Database Record (c) 2015 APA, all rights reserved).

  4. A preliminary placebo-controlled crossover trial of fludrocortisone for chronic fatigue syndrome.

    PubMed

    Peterson, P K; Pheley, A; Schroeppel, J; Schenck, C; Marshall, P; Kind, A; Haugland, J M; Lambrecht, L J; Swan, S; Goldsmith, S

    1998-04-27

    To provide a preliminary assessment of the efficacy and safety of fludrocortisone acetate treatment of chronic fatigue syndrome. A placebo-controlled, double-blind, random-allocation crossover trial of 6 weeks of fludrocortisone. An outpatient clinical trials unit. Twenty-five participants with chronic fatigue syndrome (mean age, 40 years; 19 [76%] women; mean duration of illness, 7.0 years) were recruited from a research and clinic registry. Five patients withdrew from the trial. All participants were scheduled to receive fludrocortisone acetate (0.1-0.2 mg) or a placebo for 6 weeks in each treatment. Self-administered questionnaires were completed at the beginning and end of each treatment arm that asked patients to rate the severity of their symptoms on a visual analogue scale. The Medical Outcomes Study 36-Item Short-Form Health Survey, a reaction time test, and a treadmill exercise test were used to assess functional status. Blood pressure, heart rate, and plasma norepinephrine levels were obtained at baseline. Blood pressure and heart rate were recorded at the end of the exercise test and monitored at all subsequent visits. At baseline, the study participants reported symptom severity greater than 5 for most symptoms, and all had evidence of marked functional impairments. No improvement was observed in the severity of any symptom or in any test of function for the 20 participants who completed both arms of the trial. Blood pressure and heart rate readings were unaffected by treatment, and plasma norepinephrine levels did not differ from those of a healthy control group. The incidence of adverse experiences was similar in the fludrocortisone and placebo arms of the trial. Low-dose fludrocortisone does not provide sufficient benefit to be evident in a preliminary blinded trial of unselected patients with chronic fatigue syndrome.

  5. Is Social Categorization the Missing Link Between Weak Central Coherence and Mental State Inference Abilities in Autism? Preliminary Evidence from a General Population Sample.

    PubMed

    Skorich, Daniel P; May, Adrienne R; Talipski, Louisa A; Hall, Marnie H; Dolstra, Anita J; Gash, Tahlia B; Gunningham, Beth H

    2016-03-01

    We explore the relationship between the 'theory of mind' (ToM) and 'central coherence' difficulties of autism. We introduce covariation between hierarchically-embedded categories and social information--at the local level, the global level, or at both levels simultaneously--within a category confusion task. We then ask participants to infer the mental state of novel category members, and measure participants' autism-spectrum quotient (AQ). Results reveal a positive relationship between AQ and the degree of local/global social categorization, which in turn predicts the pattern of mental state inferences. These results provide preliminary evidence for a causal relationship between central coherence and ToM abilities. Implications with regard to ToM processes, social categorization, intervention, and the development of a unified account of autism are discussed.

  6. 10 CFR 960.3-1-4 - Evidence for siting decisions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Evidence for siting decisions. 960.3-1-4 Section 960.3-1-4 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-4 Evidence for siting decisions. The siting...

  7. 10 CFR 960.3-1-4 - Evidence for siting decisions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Evidence for siting decisions. 960.3-1-4 Section 960.3-1-4 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-4 Evidence for siting decisions. The siting...

  8. 10 CFR 960.3-1-4 - Evidence for siting decisions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Evidence for siting decisions. 960.3-1-4 Section 960.3-1-4 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-4 Evidence for siting decisions. The siting...

  9. 10 CFR 960.3-1-4 - Evidence for siting decisions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Evidence for siting decisions. 960.3-1-4 Section 960.3-1-4 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-4 Evidence for siting decisions. The siting...

  10. Preliminary Results Obtained in Integrated Safety Analysis of NASA Aviation Safety Program Technologies

    NASA Technical Reports Server (NTRS)

    Reveley, Mary S.

    2003-01-01

    The goal of the NASA Aviation Safety Program (AvSP) is to develop and demonstrate technologies that contribute to a reduction in the aviation fatal accident rate by a factor of 5 by the year 2007 and by a factor of 10 by the year 2022. Integrated safety analysis of day-to-day operations and risks within those operations will provide an understanding of the Aviation Safety Program portfolio. Safety benefits analyses are currently being conducted. Preliminary results for the Synthetic Vision Systems (SVS) and Weather Accident Prevention (WxAP) projects of the AvSP have been completed by the Logistics Management Institute under a contract with the NASA Glenn Research Center. These analyses include both a reliability analysis and a computer simulation model. The integrated safety analysis method comprises two principal components: a reliability model and a simulation model. In the reliability model, the results indicate how different technologies and systems will perform in normal, degraded, and failed modes of operation. In the simulation, an operational scenario is modeled. The primary purpose of the SVS project is to improve safety by providing visual-flightlike situation awareness during instrument conditions. The current analyses are an estimate of the benefits of SVS in avoiding controlled flight into terrain. The scenario modeled has an aircraft flying directly toward a terrain feature. When the flight crew determines that the aircraft is headed toward an obstruction, the aircraft executes a level turn at speed. The simulation is ended when the aircraft completes the turn.

  11. Preliminary Obtained Data from Borehole Geodetic Measurements in Marmara Region, Turkey

    NASA Astrophysics Data System (ADS)

    Ozener, H.; Aktug, B.; Karabulut, H.; Ergintav, S.; Dogru, A.; Yilmaz, O.; Turgut, B.; Ahiska, B.; Mencin, D.; Mattioli, G. S.

    2014-12-01

    Dense continuous GPS networks quantify the time-dependent deformation field of the earthquake cycle. However the strainmeters can capture signals with superior precision at local spatial scales, in particular in the short-period, from minutes to a month. Many relatively small-scale events (e.i. SSEs, creeps) have been successfully determined on the subduction zones. Istanbul located near the most active parts of the North Anatolian Fault (NAF) has been monitored by different observing techniques such as seismic networks and continuous/survey-mode GPS networks for decades. However, it is still essential to observe deformation in a broad range of temporal and spatial scales (from seismology to geodesy and to geology). Borehole strainmeters are very sensitive to deformation in the range of less than a month. In this study, we present a new project, financially and technically supported by Istanbul Development Agency (ISTKA) and UNAVCO, respectively, which includes the installation of two borehole strainmeters are being deployed in European side of Istanbul in Marmara Region. Since these instruments can also respond to non-tectonic processes, it is necessary to have more instruments to increase spatial coherence and to have additional sensors to detect and model noise (such as barometric pressure, tides, or precipitation). The introduced monitoring system will provide significant insight about the creeping phenomenon and the possible SSE to our understanding of seismic hazards in active zones and possible precursors. Our long term objective is to build a borehole monitoring system in the region. By integrating various data obtained from borehole observations, we expect to get a better understanding of dynamics in the western NAF. In this presentation, we introduce data and ongoing analysis obtained with strainmeters.

  12. Preliminary Evidence for Cognitive Mediation During Cognitive–Behavioral Therapy of Panic Disorder

    PubMed Central

    Hofmann, Stefan G.; Suvak, Michael K.; Barlow, David H.; Shear, M. Katherine; Meuret, Alicia E.; Rosenfield, David; Gorman, Jack M.; Woods, Scott W.

    2007-01-01

    Cognitive–behavioral therapy (CBT) and pharmacotherapy are similarly effective for treating panic disorder with mild or no agoraphobia, but little is known about the mechanism through which these treatments work. The present study examined some of the criteria for cognitive mediation of treatment change in CBT alone, imipramine alone, CBT plus imipramine, and CBT plus placebo. Ninety-one individuals who received 1 of these interventions were assessed before and after acute treatment, and after a 6-month maintenance period. Multilevel moderated mediation analyses provided preliminary support for the notion that changes in panic-related cognitions mediate changes in panic severity only in treatments that include CBT. PMID:17563154

  13. Preliminary tests of the electrostatic plasma accelerator

    NASA Technical Reports Server (NTRS)

    Aston, G.; Acker, T.

    1990-01-01

    This report describes the results of a program to verify an electrostatic plasma acceleration concept and to identify those parameters most important in optimizing an Electrostatic Plasma Accelerator (EPA) thruster based upon this thrust mechanism. Preliminary performance measurements of thrust, specific impulse and efficiency were obtained using a unique plasma exhaust momentum probe. Reliable EPA thruster operation was achieved using one power supply.

  14. Financial Decision-making Abilities and Financial Exploitation in Older African Americans: Preliminary Validity Evidence for the Lichtenberg Financial Decision Rating Scale (LFDRS)

    PubMed Central

    Ficker, Lisa J.; Rahman-Filipiak, Annalise

    2015-01-01

    This study examines preliminary evidence for the Lichtenberg Financial Decision Rating Scale (LFDRS), a new person-centered approach to assessing capacity to make financial decisions, and its relationship to self-reported cases of financial exploitation in 69 older African Americans. More than one third of individuals reporting financial exploitation also had questionable decisional abilities. Overall, decisional ability score and current decision total were significantly associated with cognitive screening test and financial ability scores, demonstrating good criterion validity. Financially exploited individuals, and non-exploited individuals, showed mean group differences on the Mini Mental State Exam, Financial Situational Awareness, Psychological Vulnerability, Current Decisional Ability, and Susceptibility to undue influence subscales, and Total Lichtenberg Financial Decision Rating Scale Score. Study findings suggest that impaired decisional abilities may render older adults more vulnerable to financial exploitation, and that the LFDRS is a valid tool for measuring both decisional abilities and financial exploitation. PMID:26285038

  15. Development and Preliminary Validation of the Time Management for Exercise Scale

    ERIC Educational Resources Information Center

    Hellsten, Laurie-ann M.; Rogers, W. Todd

    2009-01-01

    The purpose of this study was to collect preliminary validity evidence for a time management scale for exercise. An initial pool of 91 items was developed from existing literature. Ten exercise/health psychologists evaluated each of the items in terms of relevance and representativeness. Forty-nine items met all criteria. Exploratory factor…

  16. Preliminary evidence that different mechanisms underlie the anger superiority effect in children with and without Autism Spectrum Disorders

    PubMed Central

    Isomura, Tomoko; Ogawa, Shino; Yamada, Satoko; Shibasaki, Masahiro; Masataka, Nobuo

    2014-01-01

    Previous studies have demonstrated that angry faces capture humans' attention more rapidly than emotionally positive faces. This phenomenon is referred to as the anger superiority effect (ASE). Despite atypical emotional processing, adults and children with Autism Spectrum Disorders (ASD) have been reported to show ASE as well as typically developed (TD) individuals. So far, however, few studies have clarified whether or not the mechanisms underlying ASE are the same for both TD and ASD individuals. Here, we tested how TD and ASD children process schematic emotional faces during detection by employing a recognition task in combination with a face-in-the-crowd task. Results of the face-in-the-crowd task revealed the prevalence of ASE both in TD and ASD children. However, the results of the recognition task revealed group differences: In TD children, detection of angry faces required more configural face processing and disrupted the processing of local features. In ASD children, on the other hand, it required more feature-based processing rather than configural processing. Despite the small sample sizes, these findings provide preliminary evidence that children with ASD, in contrast to TD children, show quick detection of angry faces by extracting local features in faces. PMID:24904477

  17. Hellenic Amateur Astronomy Association's activities: Preliminary results on Perseids 2010

    NASA Astrophysics Data System (ADS)

    Maravelias, G.

    2011-01-01

    Preliminary results on the Perseids 2010 are presented. Visual and video observations were obtained by the author and a first reduction of the visual data shows that a maximum of ZHR ~120 was reached during the night 12-13 of August 2010. Moreover, a video setup was tested (DMK camera and UFO Capture v2) and the results show that, under some limitations, valuable data can be obtained.

  18. The cost of child health inequalities in Aotearoa New Zealand: a preliminary scoping study.

    PubMed

    Mills, Clair; Reid, Papaarangi; Vaithianathan, Rhema

    2012-05-28

    Health inequalities have been extensively documented, internationally and in New Zealand. The cost of reducing health inequities is often perceived as high; however, recent international studies suggest the cost of "doing nothing" is itself significant. This study aimed to develop a preliminary estimate of the economic cost of health inequities between Māori (indigenous) and non-Māori children in New Zealand. Standard quantitative epidemiological methods and "cost of illness" methodology were employed, within a Kaupapa Māori theoretical framework. Data were obtained from national data collections held by the New Zealand Health Information Service and other health sector agencies. Preliminary estimates suggest child health inequities between Māori and non-Māori in New Zealand are cost-saving to the health sector. However the societal costs are significant. A conservative "base case" scenario estimate is over $NZ62 million per year, while alternative costing methods yield larger costs of nearly $NZ200 million per annum. The total cost estimate is highly sensitive to the costing method used and Value of Statistical Life applied, as the cost of potentially avoidable deaths of Māori children is the major contributor to this estimate. This preliminary study suggests that health sector spending is skewed towards non-Māori children despite evidence of greater Māori need. Persistent child health inequities result in significant societal economic costs. Eliminating child health inequities, particularly in primary care access, could result in significant economic benefits for New Zealand. However, there are conceptual, ethical and methodological challenges in estimating the economic cost of child health inequities. Re-thinking of traditional economic frameworks and development of more appropriate methodologies is required.

  19. Preliminary Results from the Application of Automated Adjoint Code Generation to CFL3D

    NASA Technical Reports Server (NTRS)

    Carle, Alan; Fagan, Mike; Green, Lawrence L.

    1998-01-01

    This report describes preliminary results obtained using an automated adjoint code generator for Fortran to augment a widely-used computational fluid dynamics flow solver to compute derivatives. These preliminary results with this augmented code suggest that, even in its infancy, the automated adjoint code generator can accurately and efficiently deliver derivatives for use in transonic Euler-based aerodynamic shape optimization problems with hundreds to thousands of independent design variables.

  20. Papain wound dressings obtained from poly(vinyl alcohol)/calcium alginate blends as new pharmaceutical dosage form: Preparation and preliminary evaluation.

    PubMed

    Dutra, J A P; Carvalho, S G; Zampirolli, A C D; Daltoé, R D; Teixeira, R M; Careta, F P; Cotrim, M A P; Oréfice, R L; Villanova, J C O

    2017-04-01

    Transparent, soft, flexible, mechanically resistant films, which are ideal for use as wound dressings were prepared in the presence of 2% papain, a proteolytic enzyme that can play a role in the chemical debridement of the skin and can accelerate the healing process. The films, based on poly(vinyl alcohol):calcium alginate blends with increasing concentrations of polysaccharide (10, 20, and 30% v/v), were obtained by casting method. FTIR and DSC analyses were performed to assess the composition and miscibility of blends. Mechanical properties such as tensile strength, elasticity modulus, and elongation at breakpoint were evaluated. The influence of different concentrations of calcium alginate on physical attributes of films like wettability, swelling capacity and mechanical properties was determined. The stability of papain in the films was assessed indirectly by hemolytic activity assay employing direct contact method and confirmed by technique based on blood agar diffusion. Preliminary cytotoxicity was evaluated with the XTT method. The results showed that at the polymer concentrations tested, the blends were miscible. The increase in the content of the calcium alginate increased the wettability and swelling capacity of the films, which is desirable in wound dressings. On the other hand, mechanical resistance decreased without causing breakage of the films during the swelling tests. The hemolytic activity of the films was maintained during the studied period, suggesting the stability of papain in the proposed formulations. Cellular viability indicated that the films were non-toxic. The analysis of the results showed that it is possible to prepare interactive and bioactive wound dressing containing papain from blends of PVA and calcium alginate polymers. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. 29 CFR 1955.30 - Submission of documentary evidence.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false Submission of documentary evidence. 1955.30 Section 1955.30 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) PROCEDURES FOR WITHDRAWAL OF APPROVAL OF STATE PLANS Preliminary Conference and Discovery § 1955.30 Submission of...

  2. 29 CFR 1955.30 - Submission of documentary evidence.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 9 2013-07-01 2013-07-01 false Submission of documentary evidence. 1955.30 Section 1955.30 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) PROCEDURES FOR WITHDRAWAL OF APPROVAL OF STATE PLANS Preliminary Conference and Discovery § 1955.30 Submission of...

  3. 29 CFR 1955.30 - Submission of documentary evidence.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Submission of documentary evidence. 1955.30 Section 1955.30 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) PROCEDURES FOR WITHDRAWAL OF APPROVAL OF STATE PLANS Preliminary Conference and Discovery § 1955.30 Submission of...

  4. 29 CFR 1955.30 - Submission of documentary evidence.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 9 2011-07-01 2011-07-01 false Submission of documentary evidence. 1955.30 Section 1955.30 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) PROCEDURES FOR WITHDRAWAL OF APPROVAL OF STATE PLANS Preliminary Conference and Discovery § 1955.30 Submission of...

  5. 29 CFR 1955.30 - Submission of documentary evidence.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 9 2012-07-01 2012-07-01 false Submission of documentary evidence. 1955.30 Section 1955.30 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) PROCEDURES FOR WITHDRAWAL OF APPROVAL OF STATE PLANS Preliminary Conference and Discovery § 1955.30 Submission of...

  6. Evaluation and Preliminary Results of the New USNO PPS Timing Receiver

    DTIC Science & Technology

    2000-11-01

    timing receiver, one may currently obtain raw pseudorange and carrier-phase data by periodically downloading such data from a flashcard . Several...preliminary experiments have been performed using data collected from the prototype TTR- 12 receivers’ flashcards and geodetic GPS carrier-phase techniques

  7. White matter structure in loneliness: preliminary findings from diffusion tensor imaging.

    PubMed

    Tian, Yin; Liang, Shanshan; Yuan, Zhen; Chen, Sifan; Xu, Peng; Yao, Dezhong

    2014-08-06

    A pilot study was carried out to determine individual differences in perceived loneliness using diffusion tensor imaging. To the best of our knowledge, this is the first preliminary diffusion tensor imaging evidence that the ventral attention network, generally activated by attentional reorienting, was also related to loneliness. Image reconstruction results indicated significantly decreased fractional anisotropy of white matter fibers and that associated nodes of the ventral attention network are highly correlated with increased loneliness ratings. By providing evidence on the structural level, our findings suggested that attention-reorienting capabilities play an important role in shaping an individual's loneliness.

  8. Preliminary performances measured on a CMOS long linear array for space application

    NASA Astrophysics Data System (ADS)

    Renard, Christophe; Artinian, Armand; Dantes, Didier; Lepage, Gérald; Diels, Wim

    2017-11-01

    This paper presents the design and the preliminary performances of a CMOS linear array, resulting from collaboration between Alcatel Alenia Space and Cypress Semiconductor BVBA, which takes advantage of emerging potentialities of CMOS technologies. The design of the sensor is presented: it includes 8000 panchromatic pixels with up to 25 rows used in TDI mode, and 4 lines of 2000 pixels for multispectral imaging. Main system requirements and detector tradeoffs are recalled, and the preliminary test results obtained with a first generation prototype are summarized and compared with predicted performances.

  9. A sampling-based computational strategy for the representation of epistemic uncertainty in model predictions with evidence theory.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Johnson, J. D.; Oberkampf, William Louis; Helton, Jon Craig

    2006-10-01

    Evidence theory provides an alternative to probability theory for the representation of epistemic uncertainty in model predictions that derives from epistemic uncertainty in model inputs, where the descriptor epistemic is used to indicate uncertainty that derives from a lack of knowledge with respect to the appropriate values to use for various inputs to the model. The potential benefit, and hence appeal, of evidence theory is that it allows a less restrictive specification of uncertainty than is possible within the axiomatic structure on which probability theory is based. Unfortunately, the propagation of an evidence theory representation for uncertainty through a modelmore » is more computationally demanding than the propagation of a probabilistic representation for uncertainty, with this difficulty constituting a serious obstacle to the use of evidence theory in the representation of uncertainty in predictions obtained from computationally intensive models. This presentation describes and illustrates a sampling-based computational strategy for the representation of epistemic uncertainty in model predictions with evidence theory. Preliminary trials indicate that the presented strategy can be used to propagate uncertainty representations based on evidence theory in analysis situations where naive sampling-based (i.e., unsophisticated Monte Carlo) procedures are impracticable due to computational cost.« less

  10. The cost of child health inequalities in Aotearoa New Zealand: a preliminary scoping study

    PubMed Central

    2012-01-01

    Background Health inequalities have been extensively documented, internationally and in New Zealand. The cost of reducing health inequities is often perceived as high; however, recent international studies suggest the cost of “doing nothing” is itself significant. This study aimed to develop a preliminary estimate of the economic cost of health inequities between Māori (indigenous) and non-Māori children in New Zealand. Methods Standard quantitative epidemiological methods and “cost of illness” methodology were employed, within a Kaupapa Māori theoretical framework. Data were obtained from national data collections held by the New Zealand Health Information Service and other health sector agencies. Results Preliminary estimates suggest child health inequities between Māori and non-Māori in New Zealand are cost-saving to the health sector. However the societal costs are significant. A conservative “base case” scenario estimate is over $NZ62 million per year, while alternative costing methods yield larger costs of nearly $NZ200 million per annum. The total cost estimate is highly sensitive to the costing method used and Value of Statistical Life applied, as the cost of potentially avoidable deaths of Māori children is the major contributor to this estimate. Conclusions This preliminary study suggests that health sector spending is skewed towards non-Māori children despite evidence of greater Māori need. Persistent child health inequities result in significant societal economic costs. Eliminating child health inequities, particularly in primary care access, could result in significant economic benefits for New Zealand. However, there are conceptual, ethical and methodological challenges in estimating the economic cost of child health inequities. Re-thinking of traditional economic frameworks and development of more appropriate methodologies is required. PMID:22640030

  11. Preliminary Evidence for the Emergence of a Health Care Online Community of Practice: Using a Netnographic Framework for Twitter Hashtag Analytics.

    PubMed

    Roland, Damian; Spurr, Jesse; Cabrera, Daniel

    2017-07-14

    Online communities of practice (oCoPs) may emerge from interactions on social media. These communities offer an open digital space and flat role hierarchy for information sharing and provide a strong group identity, rapid flow of information, content curation, and knowledge translation. To date, there is only a small body of evidence in medicine or health care to verify the existence of an oCoP. We aimed to examine the emergence of an oCoP through the study of social media interactions of the free open access medical education (FOAM) movement. We examined social media activity in Twitter by analyzing the network centrality metrics of tweets with the #FOAMed hashtag and compared them with previously validated criteria of a community of practice (CoP). The centrality analytics of the FOAM community showed concordance with aspects of a general CoP (in terms of community, domain, and practice), as well as some specific traits of a health care community, including social control, common purpose, flat hierarchy, and network-based and concrete achievement. This study demonstrated preliminary evidence of an oCoP focused on education and based on social media interactions. Further examination of the topology of the network is needed to definitely prove the existence of an oCoP. Given that these communities result in significant knowledge translation and practice change, further research in this area appears warranted. ©Damian Roland, Jesse Spurr, Daniel Cabrera. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 14.07.2017.

  12. Preliminary Study of a Hybrid Helicon-ECR Plasma Source

    NASA Astrophysics Data System (ADS)

    M. Hala, A.; Oksuz, L.; Ximing, Zhu

    2016-08-01

    A new type of hybrid discharge is experimentally investigated in this work. A helicon source and an electron cyclotron resonance (ECR) source were combined to produce plasma. As a preliminary study of this type of plasma, the optical emission spectroscopy (OES) method was used to obtain values of electron temperature and density under a series of typical conditions. Generally, it was observed that the electron temperature decreases and the electron density increases as the pressure increased. When increasing the applied power at a certain pressure, the average electron density at certain positions in the discharge does not increase significantly possibly due to the high degree of neutral depletion. Electron temperature increased with power in the hybrid mode. Possible mechanisms of these preliminary observations are discussed.

  13. Preliminary Psychometric Analysis of the Modified Perceived Value of Certification Tool for the Nurse Educator.

    PubMed

    Barbe, Tammy

    2015-01-01

    The purpose of this study was to examine psychometric properties of the Perceived Value of Certification Tool© with a focus on nurse educator certification (PVCT-NE) in a sample of nurse educators. Greater understanding of faculty perceptions of certification is necessary to facilitate a strong cadre of nursing faculty; however, research around nurse educator certification is limited by a lack of reliable and valid instruments to measure such perceptions. Twenty-four nursing faculty from one university participated in the psychometric study, which involved completion of the PVCT-NE in a web-based survey format. Internal consistency reliability was excellent. Cronbach's alpha for the total PVCT-NE was .94 (.93 for the intrinsic subscale and .86 for the extrinsic subscale). A content validity index of .95 was obtained. There is preliminary evidence that the PVCT-NE is a reliable and valid instrument to measure perceived value of certification in nurse educators.

  14. Emergent Writing in Preschoolers: Preliminary Evidence for a Theoretical Framework

    PubMed Central

    Puranik, Cynthia S.; Lonigan, Christopher J.

    2014-01-01

    Researchers and educators use the term emergent literacy to refer to a broad set of skills and attitudes that serve as foundational skills for acquiring success in later reading and writing; however, models of emergent literacy have generally focused on reading and reading-related behaviors. Hence, the primary aim of this study was to articulate and evaluate a theoretical model of the components of emergent writing. Alternative models of the structure of individual and developmental differences of emergent writing and writing-related skills were examined in 372 preschool children who ranged in age from 3- to 5-years using confirmatory factor analysis. Results from a confirmatory factor analysis provide evidence that these emergent writing skills are best described by three correlated but distinct factors, (a) Conceptual Knowledge, (b) Procedural Knowledge, and (c) Generative Knowledge. Evidence that these three emergent writing factors show different patterns of relations to emergent literacy constructs is presented. Implications for understanding the development of writing and assessment of early writing skills are discussed. PMID:25316955

  15. Coarticulatory evidence in stuttered disfluencies

    NASA Astrophysics Data System (ADS)

    Arbisi-Kelm, Timothy

    2005-09-01

    While the disfluencies produced in stuttered speech surface at a significantly higher rate than those found in normal speech, it is less clear from the previous stuttering literature how exactly these disfluency patterns might differ in kind [Wingate (1988)]. One tendency found in normal speech is for disfluencies to remove acoustic evidence of coarticulation patterns [Shriberg (1999)]. This appears attributable to lexical search errors which prevent a speaker from accessing a word's phonological form; that is, coarticulation between words will fail to occur when segmental material from the following word is not retrieved. Since stuttering is a disorder which displays evidence of phonological but not lexical impairment, it was predicted that stuttered disfluencies would differ from normal errors in that the former would reveal acoustic evidence of word transitions. Eight speakers four stutterers and four control subjects participated in a narrative-production task, spontaneously describing a picture book. Preliminary results suggest that while both stutterers and controls did produce similar rates of disfluencies occurring without coarticulatory evidence, only the stutterers regularly produced disfluencies reflecting this transitional evidence. These results support the argument that disfluencies proper to stuttering result from a phonological deficit, while normal disfluencies are generally lexically based.

  16. Safety and preliminary efficacy of deep transcranial magnetic stimulation in MS-related fatigue

    PubMed Central

    Gaede, Gunnar; Tiede, Marina; Lorenz, Ina; Brandt, Alexander U.; Pfueller, Caspar; Dörr, Jan; Bellmann-Strobl, Judith; Piper, Sophie K.; Roth, Yiftach; Zangen, Abraham; Schippling, Sven

    2017-01-01

    Objective: To conduct a randomized, sham-controlled phase I/IIa study to evaluate the safety and preliminary efficacy of deep brain H-coil repetitive transcranial magnetic stimulation (rTMS) over the prefrontal cortex (PFC) and the primary motor cortex (MC) in patients with MS with fatigue or depression (NCT01106365). Methods: Thirty-three patients with MS were recruited to undergo 18 consecutive rTMS sessions over 6 weeks, followed by follow-up (FU) assessments over 6 weeks. Patients were randomized to receive high-frequency stimulation of the left PFC, MC, or sham stimulation. Primary end point was the safety of stimulation. Preliminary efficacy was assessed based on changes in Fatigue Severity Scale (FSS) and Beck Depression Inventory scores. Randomization allowed only analysis of preliminary efficacy for fatigue. Results: No serious adverse events were observed. Five patients terminated participation during treatment due to mild side effects. Treatment resulted in a significant median FSS decrease of 1.0 point (95%CI [0.45,1.65]), which was sustained during FU. Conclusions: H-coil rTMS is safe and well tolerated in patients with MS. The observed sustained reduction in fatigue after subthreshold MC stimulation warrants further investigation. ClinicalTrials.gov identifier: NCT01106365. Classification of evidence: This study provides Class III evidence that rTMS of the prefrontal or primary MC is not associated with serious adverse effects, although this study is underpowered to state this with any precision. PMID:29259998

  17. Corroborating evidence-based medicine.

    PubMed

    Mebius, Alexander

    2014-12-01

    Proponents of evidence-based medicine (EBM) have argued convincingly for applying this scientific method to medicine. However, the current methodological framework of the EBM movement has recently been called into question, especially in epidemiology and the philosophy of science. The debate has focused on whether the methodology of randomized controlled trials provides the best evidence available. This paper attempts to shift the focus of the debate by arguing that clinical reasoning involves a patchwork of evidential approaches and that the emphasis on evidence hierarchies of methodology fails to lend credence to the common practice of corroboration in medicine. I argue that the strength of evidence lies in the evidence itself, and not the methodology used to obtain that evidence. Ultimately, when it comes to evaluating the effectiveness of medical interventions, it is the evidence obtained from the methodology rather than the methodology that should establish the strength of the evidence. © 2014 John Wiley & Sons, Ltd.

  18. Airport Surface Delays and Causes: A Preliminary Analysis

    NASA Technical Reports Server (NTRS)

    Chin, David K.; Goldberg, Jay; Tang, Tammy

    1997-01-01

    This report summarizes FAA Program Analysis and Operations Research Service (ASD-400)/Lockheed Martin activities and findings related to airport surface delays and causes, in support of NASA Langley Research Center's Terminal Area Productivity (TAP) Program. The activities described in this report were initiated in June 1995. A preliminary report was published on September 30, 1995. The final report incorporates data collection forms filled out by traffic managers, other FAA staff, and an airline for the New York City area, some updates, data previously requested from various sources to support this analysis, and further quantification and documentation than in the preliminary report. This final report is based on data available as of April 12, 1996. This report incorporates data obtained from review and analysis of data bases and literature, discussions/interviews with engineers, air-traffic staff, other FAA technical personnel, and airline staff, site visits, and a survey on surface delays and causes. It includes analysis of delay statistics; preliminary findings and conclusions on surface movement, surface delay sources and causes, runway occupancy time (ROT), and airport characteristics impacting surface operations and delays; and site-specific data on the New York City area airports, which are the focus airports for this report.

  19. Competence and Drug Use: Theoretical Frameworks, Empirical Evidence and Measurement.

    ERIC Educational Resources Information Center

    Lindenberg, Cathy Strachan; Solorzano, Rosa; Kelley, Maureen; Darrow, Vicki; Gendrop, Sylvia C.; Strickland, Ora

    1998-01-01

    Discusses the Social Stress Model of Substance Abuse. Summarizes theoretical and conceptual formulations for the construct of competence, reviews empirical evidence for the association of competence with drug use, and describes the preliminary development of a multiscale instrument designed to assess drug-protective competence among low-income…

  20. Experience from a multicentre stroke register: a preliminary report

    PubMed Central

    Hatano, S.

    1976-01-01

    In collaboration with 15 centres in 10 countries of Africa, Asia, and Europe, WHO started a pilot study of a community-based stroke register, with standardized methods. Preliminary data were obtained on 6395 new cases of stroke in defined study communities, from May 1971 to September 1974. Information on incidence rates, clinical profiles, diagnosis, management, and course and prognosis for these patients is given. PMID:1088404

  1. Cascade Optimization Strategy with Neural Network and Regression Approximations Demonstrated on a Preliminary Aircraft Engine Design

    NASA Technical Reports Server (NTRS)

    Hopkins, Dale A.; Patnaik, Surya N.

    2000-01-01

    A preliminary aircraft engine design methodology is being developed that utilizes a cascade optimization strategy together with neural network and regression approximation methods. The cascade strategy employs different optimization algorithms in a specified sequence. The neural network and regression methods are used to approximate solutions obtained from the NASA Engine Performance Program (NEPP), which implements engine thermodynamic cycle and performance analysis models. The new methodology is proving to be more robust and computationally efficient than the conventional optimization approach of using a single optimization algorithm with direct reanalysis. The methodology has been demonstrated on a preliminary design problem for a novel subsonic turbofan engine concept that incorporates a wave rotor as a cycle-topping device. Computations of maximum thrust were obtained for a specific design point in the engine mission profile. The results (depicted in the figure) show a significant improvement in the maximum thrust obtained using the new methodology in comparison to benchmark solutions obtained using NEPP in a manual design mode.

  2. Psychometric Properties and U.S. National Norms of the Evidence-Based Practice Attitude Scale (EBPAS)

    ERIC Educational Resources Information Center

    Aarons, Gregory A.; Glisson, Charles; Hoagwood, Kimberly; Kelleher, Kelly; Landsverk, John; Cafri, Guy

    2010-01-01

    The Evidence-Based Practice Attitude Scale (EBPAS) assesses mental health and social service provider attitudes toward adopting evidence-based practices. Scores on the EBPAS derive from 4 subscales (i.e., Appeal, Requirements, Openness, and Divergence) as well as the total scale, and preliminary studies have linked EBPAS scores to clinic structure…

  3. An educational board game for learning and teaching burn care: A preliminary evaluation.

    PubMed

    Whittam, Alexander M; Chow, Whitney

    2017-01-01

    Timely and effective assessment, resuscitation and transfer of patients with severe burns has been demonstrated to improve outcome. A dedicated one-day course exists to equip all frontline emergency healthcare workers with the necessary knowledge and skills to manage severe burn injuries. More recently, a board game has been developed which aims to act as a learning and practice development tool for those managing burn injuries. We present the findings of our preliminary evaluation of this game. We played this game with a multidisciplinary group of staff including doctors, nurses and therapists. A proportion of these participants had previously completed the Emergency Management of Severe Burns (EMSB) course. We obtained subjective results from a questionnaire, using both Likert-type ratings and open-ended questions. The styling of the game and ease of instructions was rated from 'average' to 'excellent'. The relevance of questions was rated from 'good' to 'excellent'. The usefulness of the game to increase knowledge and stimulate discussion was rated between 'good' and 'excellent'. All participants stated that they would recommend the game to other healthcare professionals. This is the only burns and plastic surgery-related educational game in the literature. Educational games adhere to principles of adult learning but there is insufficient evidence in the literature to either confirm or refute their utility. Our preliminary evaluation of this game has shown that it achieves its main aims, namely to increase knowledge in burn care and to stimulate discussion. Further work is required to assess the board game.

  4. Preliminary bioelectrical impedance analysis (BIA) equation for body composition assessment in young females from Colombia

    NASA Astrophysics Data System (ADS)

    Caicedo-Eraso, J. C.; González-Correa, C. H.; González-Correa, C. A.

    2013-04-01

    A previous study showed that reported BIA equations for body composition are not suitable for Colombian population. The purpose of this study was to develop and validate a preliminary BIA equation for body composition assessment in young females from Colombia, using hydrodensitometry as reference method. A sample of 30 young females was evaluated. Inclusion and exclusion criteria were defined to minimize the variability of BIA. Height, weight, BIA, residual lung volume (RV) and underwater weight (UWW) were measured. A preliminary BIA equation was developed (r2 = 0.72, SEE = 2.48 kg) by stepwise multiple regression with fat-free mass (FFM) as dependent variable and weight, height and impedance measurements as independent variables. The quality of regression was evaluated and a cross-validation against 50% of sample confirmed that results obtained with the preliminary BIA equation is interchangeable with results obtained with hydrodensitometry (r2 = 0.84, SEE = 2.62 kg). The preliminary BIA equation can be used for body composition assessment in young females from Colombia until a definitive equation is developed. The next step will be increasing the sample, including a second reference method, as deuterium oxide dilution (D2O), and using multi-frequency BIA (MF-BIA). It would also be desirable to develop equations for males and other ethnic groups in Colombia.

  5. Preliminary Evidence for the Validity of the New Test of Everyday Reading Comprehension

    ERIC Educational Resources Information Center

    Wheldall, Kevin; McMurtry, Sarah

    2014-01-01

    The Test of Everyday Reading Comprehension (TERC) has recently been presented as an addition to the armoury of tests available for assessing the skills of low-progress readers. While comparison data for students of different ages are presented together with evidence for high test reliability, there is, as yet, no published evidence for its…

  6. Brief Report: Preliminary Proposal of a Conceptual Model of a Digital Environment for Developing Mathematical Reasoning in Students with Autism Spectrum Disorders.

    PubMed

    Santos, Maria Isabel; Breda, Ana; Almeida, Ana Margarida

    2015-08-01

    There is clear evidence that in typically developing children reasoning and sense-making are essential in all mathematical learning and understanding processes. In children with autism spectrum disorders (ASD), however, these become much more significant, considering their importance to successful independent living. This paper presents a preliminary proposal of a digital environment, specifically targeted to promote the development of mathematical reasoning in students with ASD. Given the diversity of ASD, the prototyping of this environment requires the study of dynamic adaptation processes and the development of activities adjusted to each user's profile. We present the results obtained during the first phase of this ongoing research, describing a conceptual model of the proposed digital environment. Guidelines for future research are also discussed.

  7. Deproteinated palm kernel cake-derived oligosaccharides: A preliminary study

    NASA Astrophysics Data System (ADS)

    Fan, Suet Pin; Chia, Chin Hua; Fang, Zhen; Zakaria, Sarani; Chee, Kah Leong

    2014-09-01

    Preliminary study on microwave-assisted hydrolysis of deproteinated palm kernel cake (DPKC) to produce oligosaccharides using succinic acid was performed. Three important factors, i.e., temperature, acid concentration and reaction time, were selected to carry out the hydrolysis processes. Results showed that the highest yield of DPKC-derived oligosaccharides can be obtained at a parameter 170 °C, 0.2 N SA and 20 min of reaction time.

  8. Cellulose fibers obtained by organosolv process from date palm rachis (Phoenix dactylifera L.)

    NASA Astrophysics Data System (ADS)

    Ammar, H.; Abid, M.; Abid, S.

    2012-02-01

    In this preliminary study, the chemical composition of Tunisian DPR was established and discussed. The main characteristic of this agri-residue was its high lignin content in comparison with that of alfa plant. CIMV process was used to selectively separate cellulose fibres, hemicelluloses and lignin at atmospheric pressure. The obtained unbleached pulp was analysed in accordance with Kappa index and degree of polymerisation and then bleached by treating successively with peroxyacids and hydrogen peroxide in basic media.

  9. Evidence-Based Psychological Assessment.

    PubMed

    Bornstein, Robert F

    2017-01-01

    In recent years there has been increasing emphasis on evidence-based practice in psychology (EBPP), and as is true in most health care professions, the primary focus of EBPP has been on treatment. Comparatively little attention has been devoted to applying the principles of EBPP to psychological assessment, despite the fact that assessment plays a central role in myriad domains of empirical and applied psychology (e.g., research, forensics, behavioral health, risk management, diagnosis and classification in mental health settings, documentation of neuropsychological impairment and recovery, personnel selection and placement in organizational contexts). This article outlines the central elements of evidence-based psychological assessment (EBPA), using the American Psychological Association's tripartite definition of EBPP as integration of the best available research with clinical expertise in the context of patient characteristics, culture, and preferences. After discussing strategies for conceptualizing and operationalizing evidence-based testing and evidence-based assessment, 6 core skills and 3 meta-skills that underlie proficiency in psychological assessment are described. The integration of patient characteristics, culture, and preferences is discussed in terms of the complex interaction of patient and assessor identities and values throughout the assessment process. A preliminary framework for implementing EBPA is offered, and avenues for continued refinement and growth are described.

  10. Preliminary evidence of cognitive and brain abnormalities in uncomplicated adolescent obesity.

    PubMed

    Yau, Po Lai; Kang, Esther H; Javier, David C; Convit, Antonio

    2014-08-01

    To ascertain whether pediatric obesity without clinically significant insulin resistance (IR) impacts brain structure and function. Thirty obese and 30 matched lean adolescents, all without clinically significant IR or a diagnosis of metabolic syndrome (MetS), received comprehensive endocrine, neuropsychological, and MRI evaluations. Relative to lean adolescents, obese non-IR adolescents had significantly lower academic achievement (i.e., arithmetic and spelling) and tended to score lower on working memory, attention, psychomotor efficiency, and mental flexibility. In line with our prior work on adolescent MetS, memory was unaffected in uncomplicated obesity. Reductions in the thickness of the orbitofrontal and anterior cingulate cortices as well as reductions of microstructural integrity in major white matter tracts without gross volume changes were also uncovered. It was documented, for the first time, that adolescents with uncomplicated obesity already have subtle brain alterations and lower performance in selective cognitive domains. When interpreting these preliminary data in the context of our prior reports of similar, but more extensive brain findings in obese adolescents with MetS and T2DM, it was concluded that "uncomplicated" obesity may also result in subtle brain alterations, suggesting a possible dose effect with more severe metabolic dysregulation giving rise to greater abnormalities. Copyright © 2014 The Obesity Society.

  11. Preliminary national rail plan.

    DOT National Transportation Integrated Search

    2009-10-15

    The Passenger Rail Investment and Improvement Act of 2008 (PRIIA) directed the Administrator of the Federal Railroad Administration (FRA) to develop a Preliminary National Rail Plan (PNRP or Preliminary Plan) to address the rail needs of the Nation. ...

  12. Do Chinese Readers Obtain Preview Benefit from Word "n" + 2? Evidence from Eye Movements

    ERIC Educational Resources Information Center

    Yang, Jinmian; Wang, Suiping; Xu, Yimin; Rayner, Keith

    2009-01-01

    The boundary paradigm (K. Rayner, 1975) was used to determine the extent to which Chinese readers obtain information from the right of fixation during reading. As characters are the basic visual unit in written Chinese, they were used as targets in Experiment 1 to examine whether readers obtain preview information from character "n" + 1 and…

  13. SmallWorld Behavior of the Worldwide Active Volcanoes Network: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Spata, A.; Bonforte, A.; Nunnari, G.; Puglisi, G.

    2009-12-01

    We propose a preliminary complex networks based approach in order to model and characterize volcanoes activity correlation observed on a planetary scale over the last two thousand years. Worldwide volcanic activity is in fact related to the general plate tectonics that locally drives the faults activity, that in turn controls the magma upraise beneath the volcanoes. To find correlations among different volcanoes could indicate a common underlying mechanism driving their activity and could help us interpreting the deeper common dynamics controlling their unrest. All the first evidences found testing the procedure, suggest the suitability of this analysis to investigate global volcanism related to plate tectonics. The first correlations found, in fact, indicate that an underlying common large-scale dynamics seems to drive volcanic activity at least around the Pacific plate, where it collides and subduces beneath American, Eurasian and Australian plates. From this still preliminary analysis, also more complex relationships among volcanoes lying on different tectonic margins have been found, suggesting some more complex interrelationships between different plates. The understanding of eventually detected correlations could be also used to further implement warning systems, relating the unrest probabilities of a specific volcano also to the ongoing activity to the correlated ones. Our preliminary results suggest that, as for other many physical and biological systems, an underlying organizing principle of planetary volcanoes activity might exist and it could be a small-world principle. In fact we found that, from a topological perspective, volcanoes correlations are characterized by the typical features of small-world network: a high clustering coefficient and a low characteristic path length. These features confirm that global volcanoes activity is characterized by both short and long-range correlations. We stress here the fact that numerical simulation carried out in

  14. Preliminary Work in Obtaining Site-Directed Mutants of Hen Egg White Lysozyme

    NASA Technical Reports Server (NTRS)

    Holmes, Leonard D.

    1996-01-01

    Protein crystal growth studies are recognized as a critical endeavor in the field of molecular biotechnology. The scientific applications of this field include the understanding of how enzymes function and the accumulation of accurate information of atomic structures, a key factor in the process of rational drug design. NASA has committed substantial investment and resources to the field of protein crystal growth and has conducted many microgravity protein crystal growth experiments aboard shuttle flights. Crystals grown in space tend to be larger, denser and have a more perfect habit and geometry. These improved properties gained in the microgravity environment of space result largely from the reduction of solutal convection, and the elimination of sedimentation at the growing crystal surface. Shuttle experiments have yielded many large, high quality crystals that are suitable for high resolution X-ray diffraction analysis. Examples of biologically important macromolecules which have been successfully crystallized during shuttle missions include: lysozyme, isocitrate lyase, gamma-interferon, insulin, human serum albumin and canavalin. Numerous other examples are also available. In addition to obtaining high quality crystals, investigators are also interested in learning the mechanisms by which the growth events take place. Crystallization experiments indicate that for the enzyme HEWL, measured growth rates do not follow mathematical models for 2D nucleation and dislocation-led growth of tetragonal protein crystals. As has been suggested by the laboratory of Marc L. Pusey, a possible explanation for the disagreement between observation and data is that HEWL tetraconal crystals form by aggregated units of lysozyme in supersaturated solutions. Surface measurement data was shown to fit very well with a model using an octamer unit cell as the growth unit. According to this model, the aggregation pathway and subsequent crystal growth is described by: monomer

  15. A preliminary assessment of the true morels (Morchella) in Newfoundland and Labrador

    USDA-ARS?s Scientific Manuscript database

    A preliminary assessment of true morels (Morchella) from Newfoundland and Labrador (NL) was obtained by using DNA sequence data from portions of three genes to identify 20 collections from Newfoundland and one from a remote location in Labrador. To place this work in a broader context, data on 25 co...

  16. 7 CFR 614.7 - Preliminary technical determinations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Preliminary technical determinations. 614.7 Section... Preliminary technical determinations. (a) A preliminary technical determination becomes final 30 days after... purpose of gathering additional information and discussing the facts relating to the preliminary technical...

  17. Preliminary Impact Crater Dimensions on 433 Eros from the NEAR Laser Rangefinder and Imager

    NASA Technical Reports Server (NTRS)

    Barnouin-Jha, O. S.; Garvin, J. B.; Cheng, A. F.; Zuber, M.; Smith, D.; Neumann, G.; Murchie, S.; Veverka, J.; Robinson, M.

    2001-01-01

    We report preliminary observations obtained from the NEAR Laser Rangefinder (NLR) and NEAR Multispectral Imager (MSI) for approx. 300 craters seen on 433 Eros to address Eros crater formation and degradation processes. Additional information is contained in the original extended abstract.

  18. Recruiting for Values in Healthcare: A Preliminary Review of the Evidence

    ERIC Educational Resources Information Center

    Patterson, Fiona; Prescott-Clements, Linda; Zibarras, Lara; Edwards, Helena; Kerrin, Maire; Cousans, Fran

    2016-01-01

    Displaying compassion, benevolence and respect, and preserving the dignity of patients are important for any healthcare professional to ensure the provision of high quality care and patient outcomes. This paper presents a structured search and thematic review of the research evidence relating to values-based recruitment within healthcare. Several…

  19. Seismicity in Pennsylvania: Evidence for Anthropogenic Events?

    NASA Astrophysics Data System (ADS)

    Homman, K.; Nyblade, A.

    2015-12-01

    The deployment and operation of the USArray Transportable Array (TA) and the PASEIS (XY) seismic networks in Pennsylvania during 2013 and 2014 provide a unique opportunity for investigating the seismicity of Pennsylvania. These networks, along with several permanent stations in Pennsylvania, resulted in a total of 104 seismometers in and around Pennsylvania that have been used in this study. Event locations were first obtained with Antelope Environmental Monitoring Software using P-wave arrival times. Arrival times were hand picked using a 1-5 Hz bandpass filter to within 0.1 seconds. Events were then relocated using a velocity model developed for Pennsylvania and the HYPOELLIPSE location code. In this study, 1593 seismic events occurred between February 2013 and December 2014 in Pennsylvania. These events ranged between magnitude (ML) 1.04 and 2.89 with an average MLof 1.90. Locations of the events occur across the state in many areas where no seismicity has been previously reported. Preliminary results indicate that most of these events are related to mining activity. Additional work using cross-correlation techniques is underway to examine a number of event clusters for evidence of hydraulic fracturing or wastewater injection sources.

  20. Evidence-based emergency medicine. Creating a system to facilitate translation of evidence into standardized clinical practice: a preliminary report.

    PubMed

    Wright, Stewart W; Trott, Alexander; Lindsell, Christopher J; Smith, Carol; Gibler, W Brian

    2008-01-01

    The Institute of Medicine, through its landmark report concerning errors in medicine, suggests that standardization of practice through systematic development and implementation of evidence-based clinical pathways is an effective way of reducing errors in emergency systems. The specialty of emergency medicine is well positioned to develop a complete system of innovative quality improvement, incorporating best practice guidelines with performance measures and practitioner feedback mechanisms to reduce errors and therefore improve quality of care. This article reviews the construction, ongoing development, and initial impact of such a system at a large, urban, university teaching hospital and at 2 affiliated community hospitals. The Committee for Procedural Quality and Evidence-Based Practice was formed within the Department of Emergency Medicine to establish evidence-based guidelines for nursing and provider care. The committee measures the effect of such guidelines, along with other quality measures, through pre- and postguideline patient care medical record audits. These measures are fed back to the providers in a provider-specific, peer-matched "scorecard." The Committee for Procedural Quality and Evidence-Based Practice affects practice and performance within our department. Multiple physician and nursing guidelines have been developed and put into use. Using asthma as an example, time to first nebulizer treatment and time to disposition from the emergency department decreased. Initial therapeutic agent changed and documentation improved. A comprehensive, guideline-driven, evidence-based approach to clinical practice is feasible within the structure of a department of emergency medicine. High-level departmental support with dedicated personnel is necessary for the success of such a system. Internet site development (available at http://www.CPQE.com) for product storage has proven valuable. Patient care has been improved in several ways; however, consistent and

  1. Improving eating disorders mental health literacy: a preliminary evaluation of the "Should I say something?" workshop.

    PubMed

    Gratwick-Sarll, Kassandra; Bentley, Caroline

    2014-01-01

    A repeated measures, uncontrolled, preliminary evaluation of a single 3-hour workshop-"Should I Say Something?"-aimed at improving eating disorders mental health literacy, was conducted in a sample of 177 university undergraduates. Following participation in the workshop, significant increases in eating disorder recognition and knowledge, and significant decreases in stigmatizing attitudes, were reported by participants. Moreover, 85% of participants reported that they provided assistance to someone whom they suspected had a mental health condition, including an eating disorder, during the 3-month follow-up period. This study provides preliminary evidence that "Should I Say Something?" may be effective in improving the mental health literacy of young people.

  2. Preliminary Report Regarding State Allocation Board Funding of the Los Angeles Unified School District's Belmont Learning Complex.

    ERIC Educational Resources Information Center

    Armoudian, Maria; Carman, Georgann; Havan, Artineh; Heron, Frank

    A preliminary report of the California Legislature's Joint Legislative Audit Committee presents findings on the construction team selection process for the Los Angeles Unified School District's (LAUSD's) Belmont Learning Complex. Evidence reveals a seriously flawed process that directly conflicted with existing law and practice. The report…

  3. Long range radio tracking of sea turtles and polar bear: Instrumentation and preliminary results

    NASA Technical Reports Server (NTRS)

    Baldwin, H. A.

    1972-01-01

    Instrumentation developed for studies of path behavior of the green sea turtle and migration movement of polar bear is described. Preliminary results bearing on navigation ability in these species are presented. Both species operate in difficult environments, and the problems faced in the design of electronic instrumentation for these studies are not completely specified at this time. However, the critical factors yet to be understood are primarily related to the behavior of instrumented animals. The data obtained with these experimental techniques are included, first to illustrate the technique and, second to provide initial preliminary results bearing on animal navigation.

  4. 25 CFR 11.1105 - Preliminary inquiry.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... shelter care, the children's court shall conduct a preliminary inquiry with 24 hours for the purpose of... to the parents, guardian or custodian, the children's court shall conduct a preliminary inquiry... custodian is not present at the preliminary inquiry, the children's court shall determine what efforts have...

  5. 25 CFR 11.1105 - Preliminary inquiry.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... shelter care, the children's court shall conduct a preliminary inquiry with 24 hours for the purpose of... to the parents, guardian or custodian, the children's court shall conduct a preliminary inquiry... custodian is not present at the preliminary inquiry, the children's court shall determine what efforts have...

  6. 25 CFR 11.1105 - Preliminary inquiry.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... shelter care, the children's court shall conduct a preliminary inquiry with 24 hours for the purpose of... to the parents, guardian or custodian, the children's court shall conduct a preliminary inquiry... custodian is not present at the preliminary inquiry, the children's court shall determine what efforts have...

  7. 25 CFR 11.1105 - Preliminary inquiry.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... shelter care, the children's court shall conduct a preliminary inquiry with 24 hours for the purpose of... to the parents, guardian or custodian, the children's court shall conduct a preliminary inquiry... custodian is not present at the preliminary inquiry, the children's court shall determine what efforts have...

  8. 25 CFR 11.1105 - Preliminary inquiry.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... shelter care, the children's court shall conduct a preliminary inquiry with 24 hours for the purpose of... to the parents, guardian or custodian, the children's court shall conduct a preliminary inquiry... custodian is not present at the preliminary inquiry, the children's court shall determine what efforts have...

  9. Preliminary results on complex ceramic layers deposition by atmospheric plasma spraying

    NASA Astrophysics Data System (ADS)

    Florea, Costel; Bejinariu, Costicǎ; Munteanu, Corneliu; Cimpoeşu, Nicanor

    2017-04-01

    In this article we obtain thin layers from complex ceramic powders using industrial equipment based on atmospheric plasma spraying. We analyze the influence of the substrate material roughness on the quality of the thin layers using scanning electron microscopy (SEM) and X-ray dispersive energy analyze (EDAX). Preliminary results present an important dependence between the surface state and the structural and chemical homogeneity.

  10. Anticoagulation and high dose liver radiation. A preliminary report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lightdale, C.J.; Wasser, J.; Coleman, M.

    Two groups of patients were observed for evidence of acute radiation hepatitis during high dose radiation to the liver. The first group of 18 patients with metastatic liver disease received an average of 4,050 rad to the whole liver. Half received anticoagulation with warfarin. One patient on anticoagulation developed evidence of acute radiation hepatitis while 2 patients did so without anticoagulation. Eleven patients with Hodgkin's disease received 4,000 rad to the left lobe of the liver during extended field radiation. Four of these 11 patients were anticoagulated to therapeutic range. Only one of the fully anticoagulated patients showed changes onmore » liver scan consistent with radiation hepatitis whereas three did so without anticoagulation. No serious sequelae from anticoagulation occurred in either group. These preliminary data suggest that anticoagulation may be safely administered with high dose hepatic radiation and that further trials with anticoagulation are warranted.« less

  11. 40 CFR 161.170 - Preliminary analysis.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Preliminary analysis. (a) If the product is produced by an integrated system, the applicant must provide a preliminary analysis of each technical grade of active ingredient contained in the product to identify all... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Preliminary analysis. 161.170 Section...

  12. Evidence-Based Mental Health Practices with Children Self-Efficacy Scale: Development and Preliminary Findings

    ERIC Educational Resources Information Center

    McMeel, Lorri S.; Leathers, Sonya J.; Strand, Tonya C.

    2017-01-01

    This article reviews existing measures related to evidence-based practices with children and self-efficacy and describes the development and psychometric properties of the Evidence-Based Mental Health Practices With Children Efficacy Scale. This scale was developed to assess students' and clinicians' self-efficacy in their abilities to use…

  13. A Preliminary Survey of Short Time-Scale Optical Variables with ROTSE

    NASA Astrophysics Data System (ADS)

    McKay, T.; Akerlof, C.; Balsano, R.; Bloch, J.; Casperson, D.; Gisler, G.; Kehoe, R.; Lee, B.; Marshall, S.; Rykoff, E.; Smith, D. A.; Szymanski, J.; Wren, J.; ROTSE Collaboration

    2000-12-01

    We have performed a preliminary optical survey of short timescale variability with the ROTSE-I telephoto array. The data sample is divided into two parts. The first is a survey of 256 square degrees ( 120k sources) imaged every 80 s for a cumulative 20 hrs to a sensitivity of approximately magnitude 15.5. The second is a similarly sensitive survey of 512 square degrees ( 250k sources) imaged every 80 s (with 7 minute gaps) for a total of approximately 60 hrs. A further 0.4 mag. increase in sensitivity is obtained by co-adding these frames in pairs. We have identified a variety of new variable stars in this sample, including many Delta Scuti stars and contact binaries. Preliminary characterization of these sources will be presented.

  14. Online Activities for Enhancing Sex Education Curricula: Preliminary Evidence on the Effectiveness of the Abstinence and Contraception Education Storehouse

    PubMed Central

    Raghupathy, Shobana; Klein, Charles; Card, Josefina

    2013-01-01

    The purpose of this research was to conduct a preliminary evaluation of the Abstinence and Contraception Education Storehouse (ACES), a digital, classroom-based resource designed to supplement existing sex education curricula with highly interactive materials such as video clips, multimedia polls and quizzes, and audiovisual demonstrations. 335 students ages 14–19 were randomly assigned to an ACES–based (treatment) or a standard (control) sex education curriculum. Data were collected at the onset of the intervention and 3-months after the completion of the intervention. Preliminary results were highly encouraging, with ACES participants who were sexually initiated at baseline reporting at the 3-month follow-up significant reductions in the number of times they had sex in the past four weeks. Both sexually initiated and non-sexually initiated youth who experienced the ACES curriculum also demonstrated greater intent to abstain from the sex during the follow-up period than those in the control group. PMID:24078799

  15. Online Activities for Enhancing Sex Education Curricula: Preliminary Evidence on the Effectiveness of the Abstinence and Contraception Education Storehouse.

    PubMed

    Raghupathy, Shobana; Klein, Charles; Card, Josefina

    2013-01-01

    The purpose of this research was to conduct a preliminary evaluation of the Abstinence and Contraception Education Storehouse (ACES), a digital, classroom-based resource designed to supplement existing sex education curricula with highly interactive materials such as video clips, multimedia polls and quizzes, and audiovisual demonstrations. 335 students ages 14-19 were randomly assigned to an ACES-based (treatment) or a standard (control) sex education curriculum. Data were collected at the onset of the intervention and 3-months after the completion of the intervention. Preliminary results were highly encouraging, with ACES participants who were sexually initiated at baseline reporting at the 3-month follow-up significant reductions in the number of times they had sex in the past four weeks. Both sexually initiated and non-sexually initiated youth who experienced the ACES curriculum also demonstrated greater intent to abstain from the sex during the follow-up period than those in the control group.

  16. Stuttering on function words in bilingual children who stutter: A preliminary study.

    PubMed

    Gkalitsiou, Zoi; Byrd, Courtney T; Bedore, Lisa M; Taliancich-Klinger, Casey L

    2017-01-01

    Evidence suggests young monolingual children who stutter (CWS) are more disfluent on function than content words, particularly when produced in the initial utterance position. The purpose of the present preliminary study was to investigate whether young bilingual CWS present with this same pattern. The narrative and conversational samples of four bilingual Spanish- and English-speaking CWS were analysed. All four bilingual participants produced significantly more stuttering on function words compared to content words, irrespective of their position in the utterance, in their Spanish narrative and conversational speech samples. Three of the four participants also demonstrated more stuttering on function compared to content words in their narrative speech samples in English, but only one participant produced more stuttering on function than content words in her English conversational sample. These preliminary findings are discussed relative to linguistic planning and language proficiency and their potential contribution to stuttered speech.

  17. Preliminary Evidence Assessing Social-Emotional Competences in Deaf and Hard of Hearing Infants and Toddlers Using a New Parent Questionnaire.

    PubMed

    Hintermair, Manfred; Sarimski, Klaus; Lang, Markus

    2017-04-01

    Social-emotional competences are an important developmental domain for deaf and hard of hearing (DHH) children and early diagnosis of problems is needed to ensure that DHH children receive appropriate support in this domain. In order to explore the usefulness of an instrument, which was recently developed for very young children, two studies in DHH infants and toddlers were conducted from Germany using the Social-Emotional Assessment/Evaluation Measure (Squires et al. (2013). Social-Emotional Assessment/Evaluation Measure (SEAM). Baltimore, ML: Brooks). Preliminary analysis of data obtained from a sample of 182 DHH children aged between 2 and 36 months (Study 1) suggests that it provides valid, reliable data and is suitable for use in practice. The data also corroborate well-known findings from other research in deaf education, in particular the role of parental responsivity for the development of social-emotional competences. Study 2 documents the consistency of evaluations of 44 DHH children by their mothers and by early intervention providers using the scales. Overall, the results suggest that this new evaluation instrument has potential applications in deaf educational practice but further research is needed to demonstrate its full value. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  18. Preliminary evidence of HIV seroconversion among HIV-negative men who have sex with men taking non-prescribed antiretroviral medication for HIV prevention in Miami, Florida, USA.

    PubMed

    Buttram, Mance E; Kurtz, Steven P

    2017-04-01

    Background Limited information suggests that men who have sex with men (MSM) are informally obtaining antiretroviral medication (ARVs) and using them for HIV pre-exposure prophylaxis (PrEP). Data are drawn from an on-going study examining the use of non-prescribed ARVs for PrEP. To date, 24 qualitative interviews have been conducted with HIV-negative, substance-using MSM living in Miami, Florida, USA. Data are presented from two participants who reported HIV seroconversion while using non-prescribed ARVs for PrEP. Preliminary data indicate that some young MSM: (i) lack awareness of and accurate information about the efficacious use of PrEP; (ii) obtain non-prescribed ARVs from HIV-positive sex partners and use these medications for PrEP in a way that does not provide adequate protection against HIV infection or cohere with established guidelines; and (iii) engage in multiple HIV transmission risk behaviours, including condomless anal sex and injection drug use. The informal, non-prescribed and non-medically supervised use of ARVs for HIV prevention has the potential to undermine the protective benefits of PrEP and leave men unprotected against HIV transmission and at risk for ARV resistance.

  19. Time domain simulations of preliminary breakdown pulses in natural lightning.

    PubMed

    Carlson, B E; Liang, C; Bitzer, P; Christian, H

    2015-06-16

    Lightning discharge is a complicated process with relevant physical scales spanning many orders of magnitude. In an effort to understand the electrodynamics of lightning and connect physical properties of the channel to observed behavior, we construct a simulation of charge and current flow on a narrow conducting channel embedded in three-dimensional space with the time domain electric field integral equation, the method of moments, and the thin-wire approximation. The method includes approximate treatment of resistance evolution due to lightning channel heating and the corona sheath of charge surrounding the lightning channel. Focusing our attention on preliminary breakdown in natural lightning by simulating stepwise channel extension with a simplified geometry, our simulation reproduces the broad features observed in data collected with the Huntsville Alabama Marx Meter Array. Some deviations in pulse shape details are evident, suggesting future work focusing on the detailed properties of the stepping mechanism. Preliminary breakdown pulses can be reproduced by simulated channel extension Channel heating and corona sheath formation are crucial to proper pulse shape Extension processes and channel orientation significantly affect observations.

  20. Time domain simulations of preliminary breakdown pulses in natural lightning

    PubMed Central

    Carlson, B E; Liang, C; Bitzer, P; Christian, H

    2015-01-01

    Lightning discharge is a complicated process with relevant physical scales spanning many orders of magnitude. In an effort to understand the electrodynamics of lightning and connect physical properties of the channel to observed behavior, we construct a simulation of charge and current flow on a narrow conducting channel embedded in three-dimensional space with the time domain electric field integral equation, the method of moments, and the thin-wire approximation. The method includes approximate treatment of resistance evolution due to lightning channel heating and the corona sheath of charge surrounding the lightning channel. Focusing our attention on preliminary breakdown in natural lightning by simulating stepwise channel extension with a simplified geometry, our simulation reproduces the broad features observed in data collected with the Huntsville Alabama Marx Meter Array. Some deviations in pulse shape details are evident, suggesting future work focusing on the detailed properties of the stepping mechanism. Key Points Preliminary breakdown pulses can be reproduced by simulated channel extension Channel heating and corona sheath formation are crucial to proper pulse shape Extension processes and channel orientation significantly affect observations PMID:26664815

  1. Preliminary evidence for a role of the adrenergic nervous system in generalized anxiety disorder.

    PubMed

    Zhang, Xiaobin; Norton, Joanna; Carrière, Isabelle; Ritchie, Karen; Chaudieu, Isabelle; Ryan, Joanne; Ancelin, Marie-Laure

    2017-02-15

    Generalized anxiety disorder (GAD) is a common chronic condition that is understudied compared to other psychiatric disorders. An altered adrenergic function has been reported in GAD, however direct evidence for genetic susceptibility is missing. This study evaluated the associations of gene variants in adrenergic receptors (ADRs) with GAD, with the involvement of stressful events. Data were obtained from 844 French community-dwelling elderly aged 65 or over. Anxiety disorders were assessed using the Mini-International Neuropsychiatry Interview, according to DSM-IV criteria. Eight single-nucleotide polymorphisms (SNPs) involved with adrenergic function were genotyped; adrenergic receptors alpha(1A) (ADRA1A), alpha(2A) (ADRA2A), and beta2 (ADRB2) and transcription factor TCF7L2. Questionnaires evaluated recent stressful life events as well as early environment during childhood and adolescence. Using multivariate logistic regression analyses four SNPs were significantly associated with GAD. A 4-fold modified risk was found with ADRA1A rs17426222 and rs573514, and ADRB2 rs1042713 which remained significant after Bonferroni correction. Certain variants may moderate the effect of adverse life events on the risk of GAD. Replication in larger samples is needed due to the small case number. This is the first study showing that ADR variants are susceptibility factors for GAD, further highlighting the critical role of the adrenergic nervous system in this disorder.

  2. Preliminary evidence for a role of the adrenergic nervous system in generalized anxiety disorder

    PubMed Central

    Zhang, Xiaobin; Norton, Joanna; Carrière, Isabelle; Ritchie, Karen; Chaudieu, Isabelle; Ryan, Joanne; Ancelin, Marie-Laure

    2017-01-01

    Generalized anxiety disorder (GAD) is a common chronic condition that is understudied compared to other psychiatric disorders. An altered adrenergic function has been reported in GAD, however direct evidence for genetic susceptibility is missing. This study evaluated the associations of gene variants in adrenergic receptors (ADRs) with GAD, with the involvement of stressful events. Data were obtained from 844 French community-dwelling elderly aged 65 or over. Anxiety disorders were assessed using the Mini-International Neuropsychiatry Interview, according to DSM-IV criteria. Eight single-nucleotide polymorphisms (SNPs) involved with adrenergic function were genotyped; adrenergic receptors alpha(1A) (ADRA1A), alpha(2A) (ADRA2A), and beta2 (ADRB2) and transcription factor TCF7L2. Questionnaires evaluated recent stressful life events as well as early environment during childhood and adolescence. Using multivariate logistic regression analyses four SNPs were significantly associated with GAD. A 4-fold modified risk was found with ADRA1A rs17426222 and rs573514, and ADRB2 rs1042713 which remained significant after Bonferroni correction. Certain variants may moderate the effect of adverse life events on the risk of GAD. Replication in larger samples is needed due to the small case number. This is the first study showing that ADR variants are susceptibility factors for GAD, further highlighting the critical role of the adrenergic nervous system in this disorder. PMID:28198454

  3. Preliminary results toward injection locking of an incoherent laser array

    NASA Technical Reports Server (NTRS)

    Daher, J.

    1986-01-01

    The preliminary results of phase locking an incoherent laser array to a master source in an attempt to achieve coherent operation are presented. The techniques necessary to demonstrate phase locking are described along with some topics for future consideration. As expected, the results obtained suggest that injection locking of an array, where the spacing between adjacent longitudinal modes of its elements is significantly larger than the locking bandwidth, may not be feasible.

  4. Internet-Delivered, Family-Based Treatment for Early-Onset OCD: A Preliminary Case Series

    PubMed Central

    Comer, Jonathan S.; Furr, Jami M.; Cooper-Vince, Christine E.; Kerns, Caroline E.; Chan, Priscilla T.; Edson, Aubrey L.; Khanna, Muniya; Franklin, Martin E.; Garcia, Abbe M.; Freeman, Jennifer B.

    2014-01-01

    Given the burdens of early-onset obsessive-compulsive disorder (OCD), limitations in the broad availability and accessibility of evidence-based care for affected youth present serious public health concerns. The growing potential for technological innovations to transform care for the most traditionally remote and underserved families holds enormous promise. This article presents the rationale, key considerations, and a preliminary case series for a promising behavioral telehealth innovation in the evidence-based treatment of early-onset OCD. We developed an Internet-based format for the delivery of family-based treatment for early-onset OCD directly to families in their homes, regardless of their geographic proximity to a mental health facility. Videoteleconferencing (VTC) methods were used to deliver real-time cognitive-behavioral therapy centering on exposure and response prevention to affected families. Participants in the preliminary case series included 5 children between the ages of 4 and 8 (MAge = 6.5) who received the Internet-delivered treatment format. All youth completed a full treatment course, all showed OCD symptom improvements and global severity improvements from pre- to posttreatment, all showed at least partial diagnostic response, and 60% no longer met diagnostic criteria for OCD at posttreatment. No participants got worse, and all mothers characterized the quality of services received as “excellent.” The present work adds to a growing literature supporting the potential of VTC and related computer technology for meaningfully expanding the reach of supported treatments for OCD and lays the foundation for subsequent controlled evaluations to evaluate matters of efficacy and engagement relative to standard in-office evidence-based care. PMID:24295036

  5. Prescribing smoked cannabis for chronic noncancer pain: preliminary recommendations.

    PubMed

    Kahan, Meldon; Srivastava, Anita; Spithoff, Sheryl; Bromley, Lisa

    2014-12-01

    To offer preliminary guidance on prescribing smoked cannabis for chronic pain before the release of formal guidelines. We reviewed the literature on the analgesic effectiveness of smoked cannabis and the harms of medical and recreational cannabis use. We developed recommendations on indications, contraindications, precautions, and dosing of smoked cannabis, and categorized the recommendations based on levels of evidence. Evidence is mostly level II (well conducted observational studies) and III (expert opinion). Smoked cannabis might be indicated for patients with severe neuropathic pain conditions who have not responded to adequate trials of pharmaceutical cannabinoids and standard analgesics (level II evidence). Smoked cannabis is contraindicated in patients who are 25 years of age or younger (level II evidence); who have a current, past, or strong family history of psychosis (level II evidence); who have a current or past cannabis use disorder (level III evidence); who have a current substance use disorder (level III evidence); who have cardiovascular or respiratory disease (level III evidence); or who are pregnant or planning to become pregnant (level II evidence). It should be used with caution in patients who smoke tobacco (level II evidence), who are at increased risk of cardiovascular disease (level III evidence), who have anxiety or mood disorders (level II evidence), or who are taking higher doses of opioids or benzodiazepines (level III evidence). Cannabis users should be advised not to drive for at least 3 to 4 hours after smoking, for at least 6 hours after oral ingestion, and for at least 8 hours if they experience a subjective "high" (level II evidence). The maximum recommended dose is 1 inhalation 4 times per day (approximately 400 mg per day) of dried cannabis containing 9% delta-9-tetrahydrocannabinol (level III evidence). Physicians should avoid referring patients to "cannabinoid" clinics (level III evidence). Future guidelines should be based on

  6. Preliminary study of the pilot's workload during emergency procedures in helicopters air operations.

    PubMed

    Bezerra, Flávio G V; Ribeiro, Selma L O

    2012-01-01

    Military air operations and law enforcement operations in helicopters are examples of activities that require high performance of the operator. This article aimed at presenting a preliminary analysis of data obtained in the initial study in order to validate the instruments and the research protocol that focuses on the analysis of the workload imposed on helicopter pilots in emergency situations. The research was conducted in an environment of real flight training and used the NASA-TLX Scale to assess the workload and an interview guide to obtain reports on the main tasks performed. Preliminary data obtained is related to the participation of 10 (ten) volunteer pilots with experience in different types of helicopters. Four scenarios involving helicopter emergency procedures of HB-350 "Squirrel" were outlined. For this article, the analysis used only the data regarding the Physical and Mental Demands of the NASA-TLX Scale. Preliminarily, the results indicate that the "time pressure" as a factor contributing to increase mental requirement in emergency situations in flight, and that this increase was reflected in the request of mental processes such as: identification of the breakdown, attention and monitoring parameters. Future steps include extending the sample and adding physiological tools to better understand the effects of these types of emergencies on pilot performance and flight safety.

  7. Preliminary acclimation strategies for successful startup in conventional biofilters.

    PubMed

    Elías, Ana; Barona, Astrid; Gallastegi, Gorka; Rojo, Naiara; Gurtubay, Luis; Ibarra-Berastegi, Gabriel

    2010-08-01

    The question of how to obtain the best inocula for conventional biofilters arises when an acclimation/adaptation procedure is to be applied. Bearing in mind that no standardized procedure for acclimating inocula exists, certain preliminary strategies for obtaining an active inoculum from wastewater treatment sludge are proposed in this work. Toluene was the contaminant to be degraded. Concerning the prior separation of sludge phases, no obvious advantage was found in separating the supernatant phase of the sludge before acclimation. As far as a continuous or discontinuous acclimation mode is concerned, the latter is recommended for rapidly obtaining acclimated sludge samples by operating the system for no longer than 1 month. The continuous mode rendered similar degradation rates, although it required longer operating time. Nevertheless, the great advantage of the continuous system lay in the absence of daily maintenance and the ready availability of the activated sample.

  8. Preliminary results on passive eddy current damper technology for SSME turbomachinery

    NASA Technical Reports Server (NTRS)

    Cunningham, R. E.

    1985-01-01

    Some preliminary results have been obtained for the dynamic response of a rotor operating over a speed range of 800 to 10,000 rpm. Amplitude frequency plots show the lateral vibratory response of an unbalanced rotor with and without external damping. The mode of damping is by means of eddy currents generated with 4 c shaped permanent magnets installed at the lower bearing of a vertically oriented rotor. The lower ball bearing and its damper assembly are totally immersed in liquid nitrogen at a temperature of -197 deg C (-320 deg F). These preliminary results for a referenced or base line passive eddy current damper assembly show that the amplitude of synchronous vibration is reduced at the resonant frequency. Measured damping coefficients were calculated to phi = .086; this compares with a theoretically calculated value of phi = .079.

  9. 3122 Florence: Lightcurve Analysis and Preliminary Model

    NASA Astrophysics Data System (ADS)

    Franco, Lorenzo; Bacci, Paolo; Maestripieri, Martina; Baj, Giorgio; Galli, Gianni; Marchini, Alessandro; Noschese, Alfonso; Valvasori, Adriano; Caselli, Catia; Barbieri, Lorenzo; Facchini, Mauro

    2018-04-01

    Photometric observations of 3122 Florence were carried out on 12 nights between 2017 Aug 30 and Oct 6. This allowed us to determine a synodic period range from P = 2.3568 h ± 0.0002 to 2.3576 h ± 0.0002 with amplitude ranging from A = 0.22 to 0.16 mag. Multi-band photometric sessions and low resolution visible spectrum analysis shows a taxonomic class S, according to the SMASS II classification. Using lightcurve inversion method we also obtained a preliminary shape and spin axis model of (λ = 164° ± 15, β = -86° ± 5) with a sidereal period Psid = 2.3583 h ± 0.0005.

  10. 25 CFR 700.115 - Preliminary acquisition notice.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Acquisition and Disposal of Habitations and/or Improvements § 700.115 Preliminary acquisition notice. As soon as feasible in the acquisition process, the Commission shall issue a preliminary acquisition notice.../her habitations and/or improvements. (b) Explain that such preliminary acquisition notice is not a...

  11. Timing of paleoearthquakes on the northern Hayward Fault: preliminary evidence in El Cerrito, California

    USGS Publications Warehouse

    Lienkaemper, J.J.; Schwartz, D.P.; Kelson, K.I.; Lettis, W.R.; Simpson, Gary D.; Southon, J.R.; Wanket, J.A.; Williams, P.L.

    1999-01-01

    The Working Group on California Earthquake Probabilities estimated that the northern Hayward fault had the highest probability (0.28) of producing a M7 Bay Area earthquake in 30 years (WGCEP, 1990). This probability was based, in part, on the assumption that the last large earthquake occurred on this segment in 1836. However, a recent study of historical documents concludes that the 1836 earthquake did not occur on the northern Hayward fault, thereby extending the elapsed time to at least 220 yr ago, the beginning of the written record. The average recurrence interval for a M7 on the northern Hayward is unknown. WGCEP (1990) assumed an interval of 167 years. The 1996 Working Group on Northern California Earthquake Potential estimated ~210 yr, based on extrapolations from southern Hayward paleoseismological studies and a revised estimate of 1868 slip on the southern Hayward fault. To help constrain the timing of paleoearthquakes on the northern Hayward fault for the 1999 Bay Area probability update, we excavated two trenches that cross the fault and a sag pond on the Mira Vista golf course. As the site is on the second fairway, we were limited to less than ten days to document these trenches. Analysis was aided by rapid C-14 dating of more than 90 samples which gave near real-time results with the trenches still open. A combination of upward fault terminations, disrupted strata, and discordant angular relations indicates at least four, and possibly seven or more, surface faulting earthquakes occurred during a 1630-2130 yr interval. Hence, average recurrence time could be <270 yr, but is no more than 710 yr. The most recent earthquake (MRE) occurred after AD 1640. Preliminary analysis of calibrated dates supports the assumption that no large historical (post-1776) earthquakes have ruptured the surface here, but the youngest dates need more corroboration. Analyses of pollen for presence of non-native species help to constrain the time of the MRE. The earthquake

  12. Should Non-Cognitive Skills Be Included in School Accountability Systems? Preliminary Evidence from California's CORE Districts. Evidence Speaks Reports, Vol 1, #13

    ERIC Educational Resources Information Center

    West, Martin R.

    2016-01-01

    Evidence confirms that student skills other than academic achievement and ability predict a broad range of academic and life outcomes. This evidence, along with a new federal requirement that state accountability systems include an indicator of school quality or student success not based on test scores, has sparked interest in incorporating such…

  13. Preliminary study of soil permeability properties using principal component analysis

    NASA Astrophysics Data System (ADS)

    Yulianti, M.; Sudriani, Y.; Rustini, H. A.

    2018-02-01

    Soil permeability measurement is undoubtedly important in carrying out soil-water research such as rainfall-runoff modelling, irrigation water distribution systems, etc. It is also known that acquiring reliable soil permeability data is rather laborious, time-consuming, and costly. Therefore, it is desirable to develop the prediction model. Several studies of empirical equations for predicting permeability have been undertaken by many researchers. These studies derived the models from areas which soil characteristics are different from Indonesian soil, which suggest a possibility that these permeability models are site-specific. The purpose of this study is to identify which soil parameters correspond strongly to soil permeability and propose a preliminary model for permeability prediction. Principal component analysis (PCA) was applied to 16 parameters analysed from 37 sites consist of 91 samples obtained from Batanghari Watershed. Findings indicated five variables that have strong correlation with soil permeability, and we recommend a preliminary permeability model, which is potential for further development.

  14. 28 CFR 2.48 - Revocation: Preliminary interview.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Revocation: Preliminary interview. 2.48....48 Revocation: Preliminary interview. (a) Interviewing officer. A parolee who is retaken on a warrant issued by a Commissioner shall be given a preliminary interview by an official designated by the Regional...

  15. 46 CFR 169.205 - Obtaining or renewing a Certificate of Inspection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SAILING SCHOOL VESSELS Inspection and Certification Certificate of Inspection § 169.205 Obtaining or... for inspection on Form CG-3752; and (2) Evidence that the vessel has been designated as a sailing...

  16. 46 CFR 169.205 - Obtaining or renewing a Certificate of Inspection.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SAILING SCHOOL VESSELS Inspection and Certification Certificate of Inspection § 169.205 Obtaining or... for inspection on Form CG-3752; and (2) Evidence that the vessel has been designated as a sailing...

  17. Preliminary evidence for linkage to chromosome 1q31-32, 10q23.3, and 16p13.3 in a South African cohort with bipolar disorder.

    PubMed

    Savitz, Jonathan; Cupido, Cinda-Lee; Ramesar, Raj Kumar

    2007-04-05

    Although the genetic variants predisposing to the development of bipolar disorder (BPD) have yet to be conclusively identified, replicated reports of linkage to particular chromosomal regions have been encouraging. Here we carried out a non-parametric linkage analysis of nine of these candidate loci in a unique South African sample of 47 BPD pedigrees (N = 350). Three polymorphic markers per region of interest (3 x 9) were typed in a Caucasian cohort of Afrikaner and British origin. Statistically significant evidence for linkage was obtained at 1q31-32, 10q23.3, and 16p13.3 with maximum NPL scores of 2.52, 2.01, and 1.84, respectively. Our results add to the growing evidence that these chromosomal regions harbor genetic variants that play a role in the development of bipolar spectrum illness. Negative results were obtained for the remaining six candidate loci, possibly due to limited statistical power. (c) 2006 Wiley-Liss, Inc.

  18. Internet-delivered lifestyle physical activity intervention improves body composition in multiple sclerosis: preliminary evidence from a randomized controlled trial.

    PubMed

    Pilutti, Lara A; Dlugonski, Deirdre; Sandroff, Brian M; Klaren, Rachel E; Motl, Robert W

    2014-07-01

    To examine the efficacy of a physical activity behavioral intervention for improving outcomes of body composition in persons with multiple sclerosis (MS). Secondary analysis of data from a randomized controlled trial. University research laboratory. Ambulatory persons with MS (N=82). A 6-month, internet-delivered physical activity behavioral intervention designed to increase lifestyle physical activity, primarily walking. The behavioral intervention was based on principles of social cognitive theory. Whole-body bone mineral content (BMC), bone mineral density (BMD), and soft tissue composition, using dual-energy x-ray absorptiometry. There were no significant differences between conditions posttrial on body composition outcomes using the adjusted critical value (P<.008). There was a significant effect of the intervention on whole-body BMC (P=.04, ω(2)<.001) and BMD (P=.01, ω(2)=.003) using the unadjusted critical value (P<.05). The effect of the intervention on percent body fat (P=.09, ω(2)=.001) and whole-body fat mass (P=.05, ω(2)=.003) approached significance using unadjusted criteria. There was not a significant effect on whole-body lean soft tissue (P=.28, ω(2)<.001) or body mass index (P=.86, ω(2)<.001). Our results provide preliminary evidence that an internet-delivered lifestyle physical activity intervention might improve bone health and body composition in MS. Such findings are important considering that physical activity is a modifiable behavior with the potential to confer long-term benefits for the prevention and management of fracture risk and comorbidities among those with MS. Copyright © 2014 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  19. Role of preliminary registry data in development of a clinical trial for an innovative device: a small but integral piece of a health policy initiative

    PubMed Central

    Ricci, Donald R.; de Vries, Joost; Blanc, Raphael

    2017-01-01

    ABSTRACT Establishing a national health policy at a macro level involves the integration of a series of health initiatives across a spectrum of activities, including clinical care. Evaluation of the safety and efficacy of a new medical device ultimately evolves to testing in humans. The pathway to a formal prospective clinical trial includes a stepwise appreciation of pre-clinical data and detailed analysis of data obtained from preliminary registries, where information about appropriate patient selection and use of the device is obtained. Evaluation of procedural and follow-up efficacy and safety data in a preliminary series of cases, chosen to simulate published data, allows the design and conduct of clinical trials that are required to verify preliminary observations, closing the loop on one aspect of modifying health policy decisions. PMID:28321285

  20. A preliminary study on identification of Thai rice samples by INAA and statistical analysis

    NASA Astrophysics Data System (ADS)

    Kongsri, S.; Kukusamude, C.

    2017-09-01

    This study aims to investigate the elemental compositions in 93 Thai rice samples using instrumental neutron activation analysis (INAA) and to identify rice according to their types and rice cultivars using statistical analysis. As, Mg, Cl, Al, Br, Mn, K, Rb and Zn in Thai jasmine rice and Sung Yod rice samples were successfully determined by INAA. The accuracy and precision of the INAA method were verified by SRM 1568a Rice Flour. All elements were found to be in a good agreement with the certified values. The precisions in term of %RSD were lower than 7%. The LODs were obtained in range of 0.01 to 29 mg kg-1. The concentration of 9 elements distributed in Thai rice samples was evaluated and used as chemical indicators to identify the type of rice samples. The result found that Mg, Cl, As, Br, Mn, K, Rb, and Zn concentrations in Thai jasmine rice samples are significantly different but there was no evidence that Al is significantly different from concentration in Sung Yod rice samples at 95% confidence interval. Our results may provide preliminary information for discrimination of rice samples and may be useful database of Thai rice.

  1. Overt and Latent Cardiac Effects of Ozone Inhalation in Rats: Evidence for Autonomic Modulation and Increased Myocardial Vulnerability

    EPA Science Inventory

    Background: Ozone (03) is a well-documented respiratory oxidant, but increasing epidemiologic evidence points to extra-pulmonary effects including positive associations between ambient 03 concentrations and cardiovascular morbidity/mortality. Objectives: With preliminary reports ...

  2. Evidence for Early Pleistocene Glaciation obtained from borecores collected in East-Central Alberta, Canada

    NASA Astrophysics Data System (ADS)

    Barendregt, R. W.; Andriashek, L. D.; Jackson, L. E.

    2014-12-01

    Borecores collected from the east-central region of Alberta, Canada have recently been sub-sampled and studied for paleomagnetic remanence characteristics. A preliminary magnetostratigraphy has been established for sediments previously assumed to represent multiple continental (Laurentide) glaciations, but for which no geochronology was available for the pre-late Wisconsin units. Comprised primarily of tills and lesser thicknesses of interbedded glacio-lacustrine and outwash sediments, the record is extensive, reaching to thicknesses of 300 metres within buried valleys. Most of the sampled units are not accessible from outcrop, and their sedimentology and stratigraphy is derived from core data only. The lowermost tills are reversely magnetized in the majority of borecores sampled to date. These tills are underlain by Empress Formation sediments and/or Colorado Group shales, and overlain by normally magnetized sediments. Both tills contain substantial weathering horizons at their surface, suggesting that interglacial or nonglacial conditions persisted for some time after each period of till deposition. Whether these tills represent a single Early Pleistocene glaciation, or perhaps two, will require additional borecore measurements. This new record of Early Pleistocene glaciation(s) in east-central Alberta places the westernmost extent of earliest Laurentide ice some 300 km farther westward from its previously established limit in the Saskatoon to Regina region of the western Canadian prairies, but still well short of the all-time limit and elevation reached during the Late Wisconsin (Late Pleistocene) in the foothills of the Alberta and Montana Rocky Mountains. Key Words: East-Central Alberta glacial history, Early Pleistocene (Laurentide) glaciation, till magnetostratigraphy, Quaternary history of Western Canadian Prairies, continental glaciations of North America.

  3. Evidence-based neurosurgery

    PubMed Central

    Esene, Ignatius N.; Baeesa, Saleh S.; Ammar, Ahmed

    2016-01-01

    Medical evidence is obtainable from approaches, which might be descriptive, analytic and integrative and ranked into levels of evidence, graded according to quality and summarized into strengths of recommendation. Sources of evidence range from expert opinions through well-randomized control trials to meta-analyses. The conscientious, explicit, and judicious use of current best evidence in making decisions related to the care of individual patients defines the concept of evidence-based neurosurgery (EBN). We reviewed reference books of clinical epidemiology, evidence-based practice and other previously related articles addressing principles of evidence-based practice in neurosurgery. Based on existing theories and models and our cumulative years of experience and expertise conducting research and promoting EBN, we have synthesized and presented a holistic overview of the concept of EBN. We have also underscored the importance of clinical research and its relationship to EBN. Useful electronic resources are provided. The concept of critical appraisal is introduced. PMID:27356649

  4. Preliminary Evidence for the Amplification of Global Warming in Shallow, Intertidal Estuarine Waters.

    PubMed

    Oczkowski, Autumn; McKinney, Richard; Ayvazian, Suzanne; Hanson, Alana; Wigand, Cathleen; Markham, Erin

    2015-01-01

    Over the past 50 years, mean annual water temperature in northeastern U.S. estuaries has increased by approximately 1.2°C, with most of the warming recorded in the winter and early spring. A recent survey and synthesis of data from four locations in Southern Rhode Island has led us to hypothesize that this warming may be amplified in the shallow (<1 m), nearshore portions of these estuaries. While intertidal areas are not typically selected as locations for long-term monitoring, we compiled data from published literature, theses, and reports that suggest that enhanced warming may be occurring, perhaps at rates three times higher than deeper estuarine waters. Warmer spring waters may be one of the factors influencing biota residing in intertidal regions both in general as well as at our specific sites. We observed greater abundance of fish, and size of Menidia sp., in recent (2010-2012) seine surveys compared to similar collections in 1962. While any linkages are speculative and data are preliminary, taken together they suggest that shallow intertidal portions of estuaries may be important places to look for the effects of climate change.

  5. A Preliminary Shape Model of 27 Euterpe

    NASA Astrophysics Data System (ADS)

    Stephens, R.; Warner, B. D.; Megna, R.; Coley, D.

    2011-10-01

    We obtained dense rotational lightcurves for the Main-Belt asteroid (27) Euterpe during three apparitions in 2000, 2009 and 2010 with planned observations in the summer of 2011. These were combined with sparse lightcurve data from the USNO to determine a preliminary spin vector and model shape (see Durech et al. [2] for a discussion regarding the differences between dense and sparse data sets). The analysis suggests that Euterpe has albedo features making the determination of an unambiguous spin vector and model shape difficult. So far, Euterpe's near spherical shape, low inclination, pole within 30 degrees of the plane of the solar system, and possible albedo features cause multiple pole and shape solutions to be present.

  6. South San Francisco Bay 2004 topographic lidar survey: Data overview and preliminary quality assessment

    USGS Publications Warehouse

    Foxgrover, Amy C.; Jaffe, Bruce E.

    2005-01-01

    This report details the collection of lidar in South Bay, the ground-truthing efforts, preliminary accuracy assessments, and known limitations of the data set. We describe the data generated from the survey and how to obtain it. In addition, we present maps and sample imagery that provides a revealing look into the intricate topographic features of South Bay.

  7. Mindfulness-based cognitive therapy may reduce thought suppression in previously suicidal participants: findings from a preliminary study.

    PubMed

    Hepburn, Silvia R; Crane, Catherine; Barnhofer, Thorsten; Duggan, Danielle S; Fennell, Melanie J V; Williams, J Mark G

    2009-06-01

    Thought suppression is a strategy aimed at mental control that may paradoxically increase the frequency of unwanted thoughts. This preliminary study examined effects of mindfulness-based cognitive therapy (MBCT) on thought suppression and depression in individuals with past depression and suicidality. In a randomized controlled trial design, 68 participants were allocated to an MBCT group or a treatment-as-usual waitlist control. Measures of thought suppression and depression were taken pre- and post-treatment. MBCT did not reduce thought suppression as measured by the White Bear Suppression Inventory, but significantly reduced self-reported attempts to suppress in the previous week. Preliminary evidence suggests that MBCT for suicidality may reduce thought suppression, but differential effects on thought suppression measures warrant further studies.

  8. Preliminary calibration of the ACP safeguards neutron counter

    NASA Astrophysics Data System (ADS)

    Lee, T. H.; Kim, H. D.; Yoon, J. S.; Lee, S. Y.; Swinhoe, M.; Menlove, H. O.

    2007-10-01

    The Advanced Spent Fuel Conditioning Process (ACP), a kind of pyroprocess, has been developed at the Korea Atomic Energy Research Institute (KAERI). Since there is no IAEA safeguards criteria for this process, KAERI has developed a neutron coincidence counter to make it possible to perform a material control and accounting (MC&A) for its ACP materials for the purpose of a transparency in the peaceful uses of nuclear materials at KAERI. The test results of the ACP Safeguards Neutron Counter (ASNC) show a satisfactory performance for the Doubles count measurement with a low measurement error for its cylindrical sample cavity. The neutron detection efficiency is about 21% with an error of ±1.32% along the axial direction of the cavity. Using two 252Cf neutron sources, we obtained various parameters for the Singles and Doubles rates for the ASNC. The Singles, Doubles, and Triples rates for a 252Cf point source were obtained by using the MCNPX code and the results for the ft8 cap multiplicity tally option with the values of ɛ, fd, and ft measured with a strong source most closely match the measurement results to within a 1% error. A preliminary calibration curve for the ASNC was generated by using the point model equation relationship between 244Cm and 252Cf and the calibration coefficient for the non-multiplying sample is 2.78×10 5 (Doubles counts/s/g 244Cm). The preliminary calibration curves for the ACP samples were also obtained by using an MCNPX simulation. A neutron multiplication influence on an increase of the Doubles rate for a metal ingot and UO2 powder is clearly observed. These calibration curves will be modified and complemented, when hot calibration samples become available. To verify the validity of this calibration curve, a measurement of spent fuel standards for a known 244Cm mass will be performed in the near future.

  9. Preliminary Results from Duplex Procedure for Obtain of Fe Based Materials for Automotive Applications

    NASA Astrophysics Data System (ADS)

    Crăciun, R. C.; Stanciu, S.; Geantă, V.; Voiculescu, I.; Manole, V.; Gârneţ, I. A.; Alexandru, A.; Cimpoesu, N.; Săndulache, F.

    2017-06-01

    Abstract Iron based materials still represent a high percentage from metallic materials used in industry, in general, and in automotive industry, in particular. In this case we used a duplex process in order to obtain the FeMnSiAl experimental alloy for a more efficient use of various units. In the first stage iron, manganese, silicon and aluminum were melted and mixed together using arc melting technology and for the second stage the alloy was re-melt for homogeneity in an induction furnace. Chemical composition, after each melting step, was analyzed using EDS Bruker detector for various areas and microstructural characterization using SEM, VegaTescan LMH II with SE detector, equipment. This alloy is proposed as a metallic approach of mechanical dumpers used in automotive industry for low and medium impact contacts.

  10. Mass movements on Venus - Preliminary results from Magellan cycle 1 observations

    NASA Technical Reports Server (NTRS)

    Malin, Michael C.

    1992-01-01

    A preliminary assessment of mass movements and their geomorphic characteristics as determined from visual inspection of Magellan cycle 1 synthetic aperture radar images is described. The primary data set was a catalog of over 200 ten-inch square photographic prints of full-resolution mosaic image data records. Venus exhibits unambiguous evidence of mass movements at a variety of scales. Mass movements appear mostly in the form of block and rock movements; there is little evidence of regolith and sediment movements. Unique Venusian conditions may play a role in the creation of some mass movement features. Dark (smooth) surfaces surrounding many rockslide avalanches are probably fine materials emplaced as part of the mass movement process, as airfall, surface-hugging density flows, or coarse-depleted debris flows. The size and efficiency of emplacement of landslide deposits on Venus are comparable to those seen on Mars, which in turn generally resemble terrestrial occurrences.

  11. Automatic evidence quality prediction to support evidence-based decision making.

    PubMed

    Sarker, Abeed; Mollá, Diego; Paris, Cécile

    2015-06-01

    Evidence-based medicine practice requires practitioners to obtain the best available medical evidence, and appraise the quality of the evidence when making clinical decisions. Primarily due to the plethora of electronically available data from the medical literature, the manual appraisal of the quality of evidence is a time-consuming process. We present a fully automatic approach for predicting the quality of medical evidence in order to aid practitioners at point-of-care. Our approach extracts relevant information from medical article abstracts and utilises data from a specialised corpus to apply supervised machine learning for the prediction of the quality grades. Following an in-depth analysis of the usefulness of features (e.g., publication types of articles), they are extracted from the text via rule-based approaches and from the meta-data associated with the articles, and then applied in the supervised classification model. We propose the use of a highly scalable and portable approach using a sequence of high precision classifiers, and introduce a simple evaluation metric called average error distance (AED) that simplifies the comparison of systems. We also perform elaborate human evaluations to compare the performance of our system against human judgments. We test and evaluate our approaches on a publicly available, specialised, annotated corpus containing 1132 evidence-based recommendations. Our rule-based approach performs exceptionally well at the automatic extraction of publication types of articles, with F-scores of up to 0.99 for high-quality publication types. For evidence quality classification, our approach obtains an accuracy of 63.84% and an AED of 0.271. The human evaluations show that the performance of our system, in terms of AED and accuracy, is comparable to the performance of humans on the same data. The experiments suggest that our structured text classification framework achieves evaluation results comparable to those of human performance

  12. Ambient Assisted Living and ageing: preliminary results of RITA project.

    PubMed

    Aquilano, Michela; Cavallo, Filippo; Bonaccorsi, Manuele; Esposito, Raffaele; Rovini, Erika; Filippi, Massimo; Esposito, Dario; Dario, Paolo; Carrozza, Maria Chiara

    2012-01-01

    The ageing of population is a social phenomenon that most of worldwide countries are facing. They are, and will be even more in the future, indeed trying to find solutions for improving quality of life of their elderly citizens. The project RITA wants to demonstrate that an update of the current socio-medical services with an Ambient Assisted Living (AAL) approach could improve the service efficiency and the quality of life of both elderly and caregiver. This paper presents the preliminary results obtained in RITA.

  13. Gas-chromatography and UV-spectroscopy of Hymenoptera venoms obtained by trivial centrifugation.

    PubMed

    Fox, Eduardo G P; Xu, Meng; Wang, Lei; Chen, Li; Lu, Yong-Yue

    2018-06-01

    This paper summarises gas-chromatography (GC-MS) and preliminary UV-spectroscopy analyses data of fresh, unmodified venom of aculeate hymenopterans (ants, bees, wasps), mainly focusing on red imported fire ants. No solvents nor fractionation were used at any point, which is a novel approach to describing integral toxins cocktails as proposed by Fox et al. (2018a) [1] 10.1016/j.toxicon.2018.02.050 where these results are discussed in deeper details. Herein we focus on further characterising the obtained venom extracted through a novel approach. Pertaining raw data is accessible from Fox et al. (2018b) [2] 10.17632/cpnscw2gkc.1 including further relevant information regarding the used insects, machinery settings, chemical standards.

  14. 23 CFR 645.109 - Preliminary engineering.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Preliminary engineering. 645.109 Section 645.109 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS UTILITIES Utility Relocations, Adjustments, and Reimbursement § 645.109 Preliminary engineering. (a) As...

  15. 23 CFR 645.109 - Preliminary engineering.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Preliminary engineering. 645.109 Section 645.109 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS UTILITIES Utility Relocations, Adjustments, and Reimbursement § 645.109 Preliminary engineering. (a) As...

  16. 23 CFR 645.109 - Preliminary engineering.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 23 Highways 1 2012-04-01 2012-04-01 false Preliminary engineering. 645.109 Section 645.109 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS UTILITIES Utility Relocations, Adjustments, and Reimbursement § 645.109 Preliminary engineering. (a) As...

  17. 23 CFR 645.109 - Preliminary engineering.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false Preliminary engineering. 645.109 Section 645.109 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS UTILITIES Utility Relocations, Adjustments, and Reimbursement § 645.109 Preliminary engineering. (a) As...

  18. 23 CFR 645.109 - Preliminary engineering.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Preliminary engineering. 645.109 Section 645.109 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS UTILITIES Utility Relocations, Adjustments, and Reimbursement § 645.109 Preliminary engineering. (a) As...

  19. Surveyor 3 Preliminary Science Results

    NASA Technical Reports Server (NTRS)

    1967-01-01

    Surveyor III soft-landed on the Moon at 00:04 GMT on April 20, 1967. Data obtained have significantly increased our knowledge of the Moon. The Surveyor III spacecraft was similar to Surveyor I; the only major change in scientific instrumentation was the addition of a soil mechanics surface sampler. Surveyor III results at this preliminary evaluation of data give valuable information about the relation between the surface skin of under-dense material responsible for the photometric properties and the deeper layers of material whose properties resemble those of ordinary terrestrial soils. In addition, they provide new insight into the relation between the general lunar surface as seen by Surveyor I and the interior of a large subdued crater. The new results have also contributed to our understanding of the mechanism of downhill transport. Many critical questions cannot, however, be answered until final reduction of experimental data.

  20. The development and preliminary testing of a multimedia patient-provider survivorship communication module for breast cancer survivors.

    PubMed

    Wen, Kuang-Yi; Miller, Suzanne M; Stanton, Annette L; Fleisher, Linda; Morra, Marion E; Jorge, Alexandra; Diefenbach, Michael A; Ropka, Mary E; Marcus, Alfred C

    2012-08-01

    This paper describes the development of a theory-guided and evidence-based multimedia training module to facilitate breast cancer survivors' preparedness for effective communication with their health care providers after active treatment. The iterative developmental process used included: (1) theory and evidence-based content development and vetting; (2) user testing; (3) usability testing; and (4) participant module utilization. Formative evaluation of the training module prototype occurred through user testing (n = 12), resulting in modification of the content and layout. Usability testing (n = 10) was employed to improve module functionality. Preliminary web usage data (n = 256, mean age = 53, 94.5% White, 75% college graduate and above) showed that 59% of the participants accessed the communication module, for an average of 7 min per login. The iterative developmental process was informative in enhancing the relevance of the communication module. Preliminary web usage results demonstrate the potential feasibility of such a program. Our study demonstrates survivors' openness to the use of a web-based communication skills training module and outlines a systematic iterative user and interface program development and testing process, which can serve as a prototype for others considering such an approach. Copyright © 2012. Published by Elsevier Ireland Ltd.

  1. The development and preliminary testing of a multimedia patient–provider survivorship communication module for breast cancer survivors

    PubMed Central

    Wen, Kuang-Yi; Miller, Suzanne M.; Stanton, Annette L.; Fleisher, Linda; Morra, Marion E.; Jorge, Alexandra; Diefenbach, Michael A.; Ropka, Mary E.; Marcus, Alfred C.

    2012-01-01

    Objective This paper describes the development of a theory-guided and evidence-based multimedia training module to facilitate breast cancer survivors’ preparedness for effective communication with their health care providers after active treatment. Methods The iterative developmental process used included: (1) theory and evidence-based content development and vetting; (2) user testing; (3) usability testing; and (4) participant module utilization. Results Formative evaluation of the training module prototype occurred through user testing (n = 12), resulting in modification of the content and layout. Usability testing (n = 10) was employed to improve module functionality. Preliminary web usage data (n = 256, mean age = 53, 94.5% White, 75% college graduate and above) showed that 59% of the participants accessed the communication module, for an average of 7 min per login. Conclusion The iterative developmental process was informative in enhancing the relevance of the communication module. Preliminary web usage results demonstrate the potential feasibility of such a program. Practice implications Our study demonstrates survivors’ openness to the use of a web-based communication skills training module and outlines a systematic iterative user and interface program development and testing process, which can serve as a prototype for others considering such an approach. PMID:22770812

  2. The Adolescent HIV Disclosure Cognition and Affect Scale: Preliminary Reliability and Validity.

    PubMed

    Evangeli, Michael

    2017-07-01

    Globally, there are 2 million HIV-positive 10-19-year-olds. One challenge for this population is sharing their HIV status with others (onward HIV disclosure). There are no multi-item, multidimensional scales of HIV disclosure cognitions and affect for young people living with HIV. An 18-item measure of HIV disclosure cognition and affect was developed, administered to 65 adolescents living with HIV (aged 12-16 years). Data were explored using principal component analysis and preliminary construct and criterion validity assessed. Three factors were revealed: negative disclosure attitudes and feelings, self-efficacy, and positive disclosure attitudes and feelings. The full scale and its subscales were internally consistent. The total score showed statistically significant positive relationships with HIV disclosure in the past 6 months, HIV disclosure intention and self-perception. Preliminary evidence of the measure's good psychometric properties suggests it may be helpful in future clinical and research work. © The Author 2017. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

  3. Auditory Hallucinations as Translational Psychiatry: Evidence from Magnetic Resonance Imaging

    PubMed Central

    Hugdahl, Kenneth

    2017-01-01

    In this invited review article, I present a translational perspective and overview of our research on auditory hallucinations in schizophrenia at the University of Bergen, Norway, with a focus on the neuronal mechanisms underlying the phenomenology of experiencing “hearing voices”. An auditory verbal hallucination (i.e. hearing a voice) is defined as a sensory experience in the absence of a corresponding external sensory source that could explain the phenomenological experience. I suggest a general frame or scheme for the study of auditory verbal hallucinations, called Levels of Explanation. Using a Levels of Explanation approach, mental phenomena can be described and explained at different levels (cultural, clinical, cognitive, brain-imaging, cellular and molecular). Another way of saying this is that, to advance knowledge in a research field, it is not only necessary to replicate findings, but also to show how evidence obtained with one method, and at one level of explanation, converges with evidence obtained with another method at another level. To achieve breakthroughs in our understanding of auditory verbal hallucinations, we have to advance vertically through the various levels, rather than the more common approach of staying at our favourite level and advancing horizontally (e.g., more advanced techniques and data acquisition analyses). The horizontal expansion will, however, not advance a deeper understanding of how an auditory verbal hallucination spontaneously starts and stops. Finally, I present data from the clinical, cognitive, brain-imaging, and cellular levels, where data from one level validate and support data at another level, called converging of evidence. Using a translational approach, the current status of auditory verbal hallucinations is that they implicate speech perception areas in the left temporal lobe, impairing perception of and attention to external sounds. Preliminary results also show that amygdala is implicated in the emotional

  4. Auditory Hallucinations as Translational Psychiatry: Evidence from Magnetic Resonance Imaging.

    PubMed

    Hugdahl, Kenneth

    2017-12-01

    In this invited review article, I present a translational perspective and overview of our research on auditory hallucinations in schizophrenia at the University of Bergen, Norway, with a focus on the neuronal mechanisms underlying the phenomenology of experiencing "hearing voices". An auditory verbal hallucination (i.e. hearing a voice) is defined as a sensory experience in the absence of a corresponding external sensory source that could explain the phenomenological experience. I suggest a general frame or scheme for the study of auditory verbal hallucinations, called Levels of Explanation. Using a Levels of Explanation approach, mental phenomena can be described and explained at different levels (cultural, clinical, cognitive, brain-imaging, cellular and molecular). Another way of saying this is that, to advance knowledge in a research field, it is not only necessary to replicate findings, but also to show how evidence obtained with one method, and at one level of explanation, converges with evidence obtained with another method at another level. To achieve breakthroughs in our understanding of auditory verbal hallucinations, we have to advance vertically through the various levels, rather than the more common approach of staying at our favourite level and advancing horizontally (e.g., more advanced techniques and data acquisition analyses). The horizontal expansion will, however, not advance a deeper understanding of how an auditory verbal hallucination spontaneously starts and stops. Finally, I present data from the clinical, cognitive, brain-imaging, and cellular levels, where data from one level validate and support data at another level, called converging of evidence. Using a translational approach, the current status of auditory verbal hallucinations is that they implicate speech perception areas in the left temporal lobe, impairing perception of and attention to external sounds. Preliminary results also show that amygdala is implicated in the emotional

  5. 7 CFR 3430.32 - Preliminary application review.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE COMPETITIVE AND NONCOMPETITIVE NON-FORMULA... Evaluation § 3430.32 Preliminary application review. Prior to technical examination, a preliminary review...

  6. A phenomenographic investigation into Information Literacy in nursing practice - preliminary findings and methodological issues.

    PubMed

    Forster, Marc

    2013-10-01

    Information Literacy is essential to 'evidence-based practice'; without the ability to locate evidence, evidence-based practice is rendered extremely difficult if not impossible. There is currently little evidence to show how Information Literacy is experienced by nurses or what its parameters are within evidence-based practice and therefore whether Information Literacy educational interventions are actually promoting the correct knowledge and skills. Using phenomenographic interviews the author will attempt to discover how nurses experience Information Literacy. Insights from the findings will be used to map out its parameters and to put forward a theoretical model for a course or module to develop it effectively. This article presents preliminary findings, including 7 draft categories of description of how Information Literacy is experienced in nursing. This pilot study indicates that the complete findings may be of significant potential value in the promotion and development of Information Literacy education in nursing. It is argued that such insights into how nurses actually experience the phenomenon of Information Literacy can be used to develop potentially more effective, research-based, educational interventions. Copyright © 2012 Elsevier Ltd. All rights reserved.

  7. Preliminary design for a maglev development facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Coffey, H.T.; He, J.L.; Chang, S.L.

    1992-04-01

    A preliminary design was made of a national user facility for evaluating magnetic-levitation (maglev) technologies in sizes intermediate between laboratory experiments and full-scale systems. A technical advisory committee was established and a conference was held to obtain advice on the potential requirements of operational systems and how the facility might best be configured to test these requirements. The effort included studies of multiple concepts for levitating, guiding, and propelling maglev vehicles, as well as the controls, communications, and data-acquisition and -reduction equipment that would be required in operating the facility. Preliminary designs for versatile, dual 2-MVA power supplies capable ofmore » powering attractive or repulsive systems were developed. Facility site requirements were identified. Test vehicles would be about 7.4 m (25 ft) long, would weigh form 3 to 7 metric tons, and would operate at speeds up to 67 m/s (150 mph) on a 3.3-km (2.05-mi) elevated guideway. The facility would utilize modular vehicles and guideways, permitting the substitution of levitation, propulsion, and guideway components of different designs and materials for evaluation. The vehicle would provide a test cell in which individual suspension or propulsion components or subsystems could be tested under realistic conditions. The system would allow economical evaluation of integrated systems under varying weather conditions and in realistic geometries.« less

  8. Glacial geomorphic evidence for a late climatic change on Mars

    NASA Technical Reports Server (NTRS)

    Kargel, J. S.; Strom, R. G.

    1992-01-01

    In a series of preliminary reports, we documented evidence of former glacial epochs on Mars. Apparent glacial landforms seemed to be concentrated primarily at middle to high southern latitudes. We now have additional evidence supporting the view that Martian glaciation appears to have been more extensive than previously recognized. The growth and collapse of ice sheets on Mars seems closely analogous to the growth and decline of Earth's great Pleistocene ice sheets. This implies that climate change was probably somewhat comparable on the two planets, although in the case of Mars the entire planet seems to have changed rapidly to a cold, dry present-day environment after the collapse of the ice sheets.

  9. Biomechanics of microliths manufacture: a preliminary approach to Neanderthal's motor constrains in the frame of embodied cognition.

    PubMed

    Patiño, Francia; Luque, Manuel; Terradillos-Bernal, Marcos; Martín-Loeches, Manuel

    2017-12-30

    The systems of perception and action of the brain appear as important constraining factors in human evolution under current models of embodied cognition. In this view, the emergence of certain items in the archeological record is not necessarily subsequent to the emergence of a 'symbolic' mind, but instead to the appearance of the sensory-motor systems enabling that behavior. One of the products normally absent in pre- Homo sapiens species is the standardized microlith, whose production seems very demanding for the hand due to their small size and need for fine craft. In the present study, we provide preliminary empirical evidence that the biomechanical requirements of microliths manufacture made this industry difficult to achieve by Neanderthals. The biomechanical parameters of the human hand in the manufacture of microliths are here explored in two individuals with different degrees of expertise. The figures obtained in this manner are subsequently contrasted and extrapolated to Neanderthal's hand anthropometric data, as obtained from the available literature. Results indicate that Neanderthals would exhibit lower efficiency than modern humans as a consequence of their smaller hands and shorter arms, resulting in a smaller area to distribute forces and an increased mechanical stress in the microlith manufacturing processes. This might be a plausibly contributing factor for precluding microlith production in Neanderthals on noticeable scales, in consonance with the archeological record.

  10. 33 CFR 116.10 - Preliminary review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... on a bridge's accident history or other criteria, to conduct a Preliminary Investigation. (c) The... Section 116.10 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES ALTERATION OF UNREASONABLY OBSTRUCTIVE BRIDGES § 116.10 Preliminary review. (a) Upon receipt of a written...

  11. 33 CFR 116.10 - Preliminary review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... on a bridge's accident history or other criteria, to conduct a Preliminary Investigation. (c) The... Section 116.10 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES ALTERATION OF UNREASONABLY OBSTRUCTIVE BRIDGES § 116.10 Preliminary review. (a) Upon receipt of a written...

  12. 33 CFR 116.10 - Preliminary review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... on a bridge's accident history or other criteria, to conduct a Preliminary Investigation. (c) The... Section 116.10 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES ALTERATION OF UNREASONABLY OBSTRUCTIVE BRIDGES § 116.10 Preliminary review. (a) Upon receipt of a written...

  13. 33 CFR 116.10 - Preliminary review.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... on a bridge's accident history or other criteria, to conduct a Preliminary Investigation. (c) The... Section 116.10 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES ALTERATION OF UNREASONABLY OBSTRUCTIVE BRIDGES § 116.10 Preliminary review. (a) Upon receipt of a written...

  14. 33 CFR 116.10 - Preliminary review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... on a bridge's accident history or other criteria, to conduct a Preliminary Investigation. (c) The... Section 116.10 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES ALTERATION OF UNREASONABLY OBSTRUCTIVE BRIDGES § 116.10 Preliminary review. (a) Upon receipt of a written...

  15. Separate cortical networks involved in music perception: preliminary functional MRI evidence for modularity of music processing.

    PubMed

    Schmithorst, Vincent J

    2005-04-01

    Music perception is a quite complex cognitive task, involving the perception and integration of various elements including melody, harmony, pitch, rhythm, and timbre. A preliminary functional MRI investigation of music perception was performed, using a simplified passive listening task. Group independent component analysis (ICA) was used to separate out various components involved in music processing, as the hemodynamic responses are not known a priori. Various components consistent with auditory processing, expressive language, syntactic processing, and visual association were found. The results are discussed in light of various hypotheses regarding modularity of music processing and its overlap with language processing. The results suggest that, while some networks overlap with ones used for language processing, music processing may involve its own domain-specific processing subsystems.

  16. [Preliminary survey to detect toxic substances in domestic potable water, Bogotá and Soacha, 2012].

    PubMed

    Silva, Elizabeth; Villarreal, María Elsa; Cárdenas, Omayda; Cristancho, Carlos Armando; Murillo, Carmenza; Salgado, Manuel Alberto; Nava, Gerardo

    2015-08-01

    Significant alterations may be found in the water of Bogotá´s water supply system after its purification, specifically during its distribution and storage in home reservoirs, which makes it necessary to study the final quality of the domiciliary water consumed by users. To conduct a preliminary study of toxic chemical substances in the water supplied by Bogotá´s water supply system in samples obtained from residential reservoirs and faucets. Descriptive study made in 26 homes located in Bogotá and Soacha. Two samplings were done during different seasons, each including a survey and the collection of water samples from domiciliary storage tanks and faucets. Samples were analyzed for basic physicochemical parameters, a screening test for organic and inorganic substances and the determination of heavy metals and residues of organophosphate pesticides and/or carbamates. Values obtained for conductivity, color and nitrates were acceptable, pH and turbidity were slightly high while residual chlorine levels were low; aluminum traces were found in 94% of the samples; 8% of the samples analyzed during the dry season showed organic compounds, compared to 66.7% during the rainy season, and just one positive result was obtained for inorganic compounds. Consequently, a medium risk level was observed in 11.5% of homes, low risk in 61.5% and no risk in 27.0%. The evidence showed deterioration of the domiciliary water by organic substances present in the reservoirs as well as in the water supply piping, probably caused by the formation of biofilms or organic polymers. Aluminum levels close to the top permissible limit can be explained by the presence of residual coagulants used during water treatment.

  17. Main results and experience obtained on Mir space station and experiment program for Russian segment of ISS.

    PubMed

    Utkin, V F; Lukjashchenko, V I; Borisov, V V; Suvorov, V V; Tsymbalyuk, M M

    2003-07-01

    This article presents main scientific and practical results obtained in course of scientific and applied research and experiments on Mir space station. Based on Mir experience, processes of research program formation for the Russian Segment of the ISS are briefly described. The major trends of activities planned in the frames of these programs as well as preliminary results of increment research programs implementation in the ISS' first missions are also presented. c2003 Elsevier Science Ltd. All rights reserved.

  18. Overt and Latent Cardiac Effects of Ozone Inhalation in Rats: Evidence for Autonomic Modulation and Increased Myocardial Vulnerability*

    EPA Science Inventory

    Ozone (O3) is a well-documented respiratory oxidant, but increasing epidemiologic evidence points to extra-pulmonary effects including positive associations between ambient O3 concentrations and cardiovascular morbidity/mortality. With preliminary reports linking O3 exposure wit...

  19. 14 CFR 16.223 - Evidence.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... shall be submitted in written form in advance of the oral hearing pursuant to the schedule established in the hearing officer's prehearing conference report. Written direct and rebuttal fact testimony... written testimony and evidence. Except in the case of evidence obtained by subpoena, or in the case of a...

  20. Preliminary thermal architecture of the X-IFU instrument dewar

    NASA Astrophysics Data System (ADS)

    Charles, Ivan; Daniel, Christophe; André, Jérome; Duband, Lionel; Duval, Jean-Marc; den Hartog, Roland; Mitsuda, Kazuhisa; Shinozaki, Keisuke; van Weers, Henk; Yamasaki, Noriko Y.

    2016-07-01

    The ESA Athena mission will implement 2 instruments to study the hot and energetic universe. The X-ray Integral Field Unit (X-IFU) will provide spatially resolved high resolution spectroscopy. This high energy resolution of 2.5 eV at 7 keV could be achieved thanks to TES (Transition Edge Sensor) detectors that need to be cooled to very low temperature. To obtain the required 50 mK temperature level, a careful design of the cryostat and of the cooling chain including different technologies in cascade is needed. The preliminary cryogenic architecture of the X-IFU instrument that fulfils the TES detector thermal requirements is described. In particular, the thermal design of the detector focal plane assembly (FPA), that uses three temperature stages (from 2 K to 50 mK) to limit the thermal loads on the lowest temperature stage, is described. The baseline cooling chain is based on European and Japanese mechanical coolers (Stirling, Pulse tube and Joule Thomson coolers) that precool a sub Kelvin cooler made of a 3He sorption cooler coupled with a small ADR (Adiabatic Demagnetization Refrigerator). Preliminary thermal budgets of the X-IFU cryostat are presented and discussed regarding cooling chain performances.

  1. 76 FR 67146 - Stainless Steel Butt-Weld Pipe Fittings From Italy; Extension of Time Limit for Preliminary...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-31

    ... DEPARTMENT OF COMMERCE International Trade Administration [A-475-828] Stainless Steel Butt-Weld... antidumping duty order on stainless steel butt-weld pipe fittings from Italy in the Federal Register. See... preliminary results of this review within the original time frame because it needs to obtain additional...

  2. 19 CFR 202.3 - Preliminary inquiry.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Preliminary inquiry. 202.3 Section 202.3 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.3 Preliminary inquiry. Upon the receipt of an application properly filed, the...

  3. 19 CFR 202.3 - Preliminary inquiry.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Preliminary inquiry. 202.3 Section 202.3 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.3 Preliminary inquiry. Upon the receipt of an application properly filed, the...

  4. 19 CFR 202.3 - Preliminary inquiry.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Preliminary inquiry. 202.3 Section 202.3 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.3 Preliminary inquiry. Upon the receipt of an application properly filed, the...

  5. 19 CFR 202.3 - Preliminary inquiry.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 3 2012-04-01 2012-04-01 false Preliminary inquiry. 202.3 Section 202.3 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.3 Preliminary inquiry. Upon the receipt of an application properly filed, the...

  6. 19 CFR 202.3 - Preliminary inquiry.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 3 2013-04-01 2013-04-01 false Preliminary inquiry. 202.3 Section 202.3 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.3 Preliminary inquiry. Upon the receipt of an application properly filed, the...

  7. 18 CFR 154.105 - Preliminary statement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT RATE SCHEDULES AND TARIFFS Form and Composition of Tariff § 154.105 Preliminary statement. The preliminary statement must contain a brief general description of the company's operations and may also contain a general explanation of its policies and...

  8. 40 CFR 158.345 - Preliminary analysis.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Preliminary analysis. 158.345 Section 158.345 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Product Chemistry § 158.345 Preliminary analysis. (a) If the product is produced by...

  9. 40 CFR 158.345 - Preliminary analysis.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Preliminary analysis. 158.345 Section 158.345 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Product Chemistry § 158.345 Preliminary analysis. (a) If the product is produced by...

  10. 40 CFR 158.345 - Preliminary analysis.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Preliminary analysis. 158.345 Section 158.345 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Product Chemistry § 158.345 Preliminary analysis. (a) If the product is produced by...

  11. 40 CFR 158.345 - Preliminary analysis.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Preliminary analysis. 158.345 Section 158.345 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Product Chemistry § 158.345 Preliminary analysis. (a) If the product is produced by...

  12. 40 CFR 158.345 - Preliminary analysis.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Preliminary analysis. 158.345 Section 158.345 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Product Chemistry § 158.345 Preliminary analysis. (a) If the product is produced by...

  13. Concentrating solar collector subsystem: Preliminary design package

    NASA Technical Reports Server (NTRS)

    1977-01-01

    Preliminary design data are presented for a concentrating solar collector including an attitude controller. Provided are schedules, technical status, all documents required for preliminary design, and other program activities.

  14. Preliminary Analysis of a Submerged Wave Energy Device

    NASA Astrophysics Data System (ADS)

    Wagner, J. R.; Wagner, J. J.; Hayatdavoodi, M.; Ertekin, R. C.

    2016-02-01

    Preliminary analysis of a submerged wave energy harvesting device is presented. The device is composed of a thin, horizontally submerged plate that is restricted to heave oscillations under the influence of surface waves. The submerged plate is oscillating, and it can be attached to a fixed rotor, or a piston, to harvest the wave energy. A fully submerged wave energy converter is preferred over a surface energy convertor due to its durability and less visual and physical distractions it presents. In this study, the device is subject to nonlinear shallow-water waves. Wave loads on the submerged oscillating plate are obtained via the Level I Green-Naghdi equations. The unsteady motion of the plate is obtained by solving the nonlinear equations of motion. The results are obtained for a range of waves with varying heights and periods. The amplitude and period of plate oscillations are analyzed as functions of the wave parameters and plate width. Particular attention is given to the selection of the site of desired wave field. Initial estimation on the amount of energy extraction from the device, located near shore at a given site, is provided.

  15. Apollo 17 traverse gravimeter experiment /Preliminary results/

    NASA Technical Reports Server (NTRS)

    Talwani, M.; Kahle, H.-G.

    1976-01-01

    Preliminary results of the traverse gravimeter experiment successfully performed during the Apollo 17 mission are discussed. An earth-moon gravity tie was established. On the basis of several readings, a gravity value of 162,695 + or - 5 mgal was obtained at the lunar-module landing site in the Taurus-Littrow valley. Free-air and Bouguer corrections were applied to the gravity data. The resultant Bouguer anomaly, analyzed with a two-dimensional approximation, shows a relative gravity maximum of about 25 to 30 mgal over the Taurus-Littrow valley. This maximum is interpreted in terms of a 1-km-thick block of basalt flow with a positive density contrast of 0.8 g/cu cm relative to the highland material on either side.

  16. Preliminary survey of markets and prices of forest products in the Del-Mar-Va Peninsula

    Treesearch

    George E. Doverspike

    1949-01-01

    This preliminary survey was designed to explore the present methods of marketing farm products and the problems involved in collecting price information about primary forest products. No attempt was made to initiate a permanent price-reporting service, since that was beyond the scope of the survey. However, certain price information was obtained; it is shown in table 2...

  17. 32 CFR 644.30 - Preliminary real estate work.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Preliminary real estate work. 644.30 Section 644... PROPERTY REAL ESTATE HANDBOOK Project Planning Military (army and Air Force) and Other Federal Agencies § 644.30 Preliminary real estate work. (a) Preliminary real estate work is defined as that action taken...

  18. 32 CFR 644.30 - Preliminary real estate work.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 4 2014-07-01 2013-07-01 true Preliminary real estate work. 644.30 Section 644... PROPERTY REAL ESTATE HANDBOOK Project Planning Military (army and Air Force) and Other Federal Agencies § 644.30 Preliminary real estate work. (a) Preliminary real estate work is defined as that action taken...

  19. 32 CFR 644.30 - Preliminary real estate work.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 4 2012-07-01 2011-07-01 true Preliminary real estate work. 644.30 Section 644... PROPERTY REAL ESTATE HANDBOOK Project Planning Military (army and Air Force) and Other Federal Agencies § 644.30 Preliminary real estate work. (a) Preliminary real estate work is defined as that action taken...

  20. 32 CFR 644.30 - Preliminary real estate work.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 4 2013-07-01 2013-07-01 false Preliminary real estate work. 644.30 Section 644... PROPERTY REAL ESTATE HANDBOOK Project Planning Military (army and Air Force) and Other Federal Agencies § 644.30 Preliminary real estate work. (a) Preliminary real estate work is defined as that action taken...

  1. 32 CFR 644.30 - Preliminary real estate work.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Preliminary real estate work. 644.30 Section 644... PROPERTY REAL ESTATE HANDBOOK Project Planning Military (army and Air Force) and Other Federal Agencies § 644.30 Preliminary real estate work. (a) Preliminary real estate work is defined as that action taken...

  2. Evidence-Based Intervention for Young Children Born Premature: Preliminary Evidence for Associated Changes in Physiological Regulation

    PubMed Central

    Graziano, Paulo A.; Bagner, Daniel M.; Sheinkopf, Stephen J.; Vohr, Betty R.; Lester, Barry M.

    2012-01-01

    The current study examined whether changes in maternal behaviors following an evidence-based treatment—Parent Child Interaction Therapy (PCIT)—was associated with improvements in cardiac vagal regulation in young children born premature. Participants included 28 young children (mean age = 37.79 months) that were born premature and presented with elevated externalizing behavior problems. To assess cardiac vagal regulation, resting measures of respiratory sinus arrhythmia (RSA) and RSA change (withdrawal or suppression) to a clean-up task were derived pre and post-treatment. Results indicated that an increase in behaviors mothers are taught to use during treatment (i.e., do skills—praise, reflection, and behavioral descriptions) were associated with an improvement in children’s post-treatment RSA suppression levels. The current study illustrates the important role of caregiver behavior in promoting physiological regulation in children born premature. PMID:22721742

  3. TRI Preliminary Dataset

    EPA Pesticide Factsheets

    The TRI preliminary dataset includes the most current TRI data available and reflects toxic chemical releases and pollution prevention activities that occurred at TRI facilities during the each calendar year.

  4. Some Nigerian Anti-Tuberculosis Ethnomedicines: A Preliminary Efficacy Assessment

    PubMed Central

    Ibekwe, Nneka N.; Nvau, John B.; Oladosu, Peters O.; Usman, Auwal M.; Ibrahim, Kolo; Boshoff, Helena I.; Dowd, Cynthia S.; Orisadipe, Abayomi T.; Aiyelaagbe, Olapeju; Adesomoju, Akinbo A.; Barry, Clifton E.; Okogun, Joseph I.

    2014-01-01

    Ethnopharmacological significance Nigerian herbalists possess indigenous ethnomedicinal recipes for the management of tuberculosis and related ailments. Aim of the study To carry out a collaborative preliminary modern scientific evaluation of the efficacy of some Nigerian ethnomedicines used by traditional medicine practitioners (TMPs) in the management of tuberculosis and related ailments Materials and methods Ethnomedicinal recipes (ETMs) were collected from TMPs from locations in various ecological zones of Nigeria under a collaborative understanding. The aqueous methanolic extracts of the ETMs were screened against Mycobacterium bovis, BCG and Mycobacterium tuberculosis (M. tb.) strain H37Rv using the broth microdilution method. Results Extracts of ETMs screened against BCG showed 69% activity against the organism. The activities varied from weak, ≤ 2500μg /mL to highly active, 33μg /mL 64% of the extracts were active against M. tb. The activities of the extracts against M.tb. varied from weak, ≤ 2500μg /mL to highly active, 128μg/mL. There was 77% agreement in results obtained using BCG or M. tb. as test organisms Conclusion The results show clear evidence for the efficacy of the majority of indigenous Nigerian herbal recipes in the ethnomedicinal management of tuberculosis and related ailments. BCG may be effectively used, to a great extent, as the organism for screening for potential anti-M. tb. agents. A set of prioritization criteria for the selection of plants for initial further studies for the purpose of antituberculsis drug discovery research is proposed. PMID:24911338

  5. 32 CFR 1901.11 - Preliminary information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Preliminary information. 1901.11 Section 1901.11 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS UNDER THE PRIVACY ACT OF 1974 Filing of Privacy Act Requests § 1901.11 Preliminary information. Members...

  6. 32 CFR 1901.11 - Preliminary information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Preliminary information. 1901.11 Section 1901.11 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS UNDER THE PRIVACY ACT OF 1974 Filing of Privacy Act Requests § 1901.11 Preliminary information. Members...

  7. Challenges of Obtaining Evidence-Based Information Regarding Medications and Male Fertility.

    PubMed

    Drobnis, Erma Z; Nangia, Ajay K

    2017-01-01

    In the clinic, the existing literature is insufficient to counsel our infertile men on medication use. Most studies have flaws that limit their application to evidence-based practice. In this chapter, we discuss the limitations of the current literature and the challenges to designing more useful studies. Among the most important weaknesses of existing studies is lack of power; that is, too few men are included to draw conclusions about the existence and size of medication effects. Adequate power is particularly important when confirming an absence of medication effect. Bias is also a problem in most studies. Early studies were rarely randomized, placebo-controlled, or blinded; a common example is patients receiving different medication regimes based on the severity of their symptoms-making it impossible to attribute differences between treated and untreated men to the medications. Additional bias is introduced by failing to include other factors that influence the outcome in the experimental design. A uniform population amenable to randomization and placebo-control are experimental species, and useful information has been gained from these models. However, application to humans is limited by differences from other species in route of drug administration, absorption of the drug, concentration in the male genital tract tissues, and genital tract physiology. To a lesser degree, there is variation among individual men in their response to drugs. In addition, drugs in the same class may have different effects, limiting the applicability of data across drugs of a single class. Complicating matters further, a toxic medication may seem to improve fertility endpoints by improving a disease condition that diminishes fertility. Finally, drug interactions have not been studied, and actual fertility data (pregnancy/fecundity) in humans are rare. A healthy dose of skepticism is warranted when evaluating studies of medications and male reproductive health.

  8. Preliminary Results on Lunar Interior Properties from the GRAIL Mission

    NASA Technical Reports Server (NTRS)

    Williams, James G.; Konopliv, Alexander S.; Asmar, Sami W.; Lemoine, H. Jay; Melosh, H. Jay; Neumann, Gregory A.; Phillips, Roger J.; Smith, David E.; Solomon, Sean C.; Watkins, Michael M.; hide

    2013-01-01

    The Gravity Recovery and Interior Laboratory (GRAIL) mission has provided lunar gravity with unprecedented accuracy and resolution. GRAIL has produced a high-resolution map of the lunar gravity field while also determining tidal response. We present the latest gravity field solution and its preliminary implications for the Moon's interior structure, exploring properties such as the mean density, moment of inertia of the solid Moon, and tidal potential Love number k2. Lunar structure includes a thin crust, a deep mantle, a fluid core, and a suspected solid inner core. An accurate Love number mainly improves knowledge of the fluid core and deep mantle. In the future GRAIL will search for evidence of tidal dissipation and a solid inner core.

  9. Preliminary evaluation of fiber composite reinforcement of truck frame rails

    NASA Technical Reports Server (NTRS)

    Faddoul, J. R.

    1977-01-01

    The use of graphite fiber/resin matrix composite to effectively reinforce a standard steel truck frame rail is studied. A preliminary design was made and it was determined that the reinforcement weight could be reduced by a factor of 10 when compared to a steel reinforcement. A section of a 1/3 scale reinforced rail was fabricated to demonstrate low cost manufacturing techniques. The scale rail section was then tested and increased stiffness was confirmed. No evidence of composite fatigue was found after 500,000 cycles to a fiber stress of 34,000 psi. The test specimen failed in bending in a static test at a load 50 percent greater than that predicted for a non-reinforced rail.

  10. Evidence on global medical travel.

    PubMed

    Ruggeri, Kai; Záliš, Ladislav; Meurice, Christopher R; Hilton, Ian; Ly, Terry-Lisa; Zupan, Zorana; Hinrichs, Saba

    2015-11-01

    The potential benefits of travelling across national borders to obtain medical treatment include improved care, decreased costs and reduced waiting times. However, medical travel involves additional risks, compared to obtaining treatment domestically. We review the publicly-available evidence on medical travel. We suggest that medical travel needs to be understood in terms of its potential risks and benefits so that it can be evaluated against alternatives by patients who are seeking care. We propose three domains -quality standards, informed decision-making, economic and legal protection - in which better evidence could support the development of medical travel policies.

  11. Evidence on global medical travel

    PubMed Central

    Záliš, Ladislav; Meurice, Christopher R; Hilton, Ian; Ly, Terry-Lisa; Zupan, Zorana; Hinrichs, Saba

    2015-01-01

    Abstract The potential benefits of travelling across national borders to obtain medical treatment include improved care, decreased costs and reduced waiting times. However, medical travel involves additional risks, compared to obtaining treatment domestically. We review the publicly-available evidence on medical travel. We suggest that medical travel needs to be understood in terms of its potential risks and benefits so that it can be evaluated against alternatives by patients who are seeking care. We propose three domains –quality standards, informed decision-making, economic and legal protection – in which better evidence could support the development of medical travel policies. PMID:26549906

  12. 32 CFR 1800.11 - Preliminary information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Preliminary information. 1800.11 Section 1800.11... ACCESS TO NACIC RECORDS UNDER THE FREEDOM OF INFORMATION ACT (FOIA) Filing of FOIA Requests § 1800.11 Preliminary information. Members of the public shall address all communications to the NACIC Coordinator as...

  13. Preliminary Drill Sites

    DOE Data Explorer

    Lane, Michael

    2013-06-28

    Preliminary locations for intermediate depth temperature gradient holes and/or resource confirmation wells based on compilation of geological, geophysical and geochemical data prior to carrying out the DOE-funded reflection seismic survey.

  14. Dissemination and Implementation of Evidence-Based Practices: Training and Consultation as Implementation Strategies

    PubMed Central

    Edmunds, Julie M.; Beidas, Rinad S.; Kendall, Philip C.

    2013-01-01

    To provide effective treatment for individuals with mental health needs, there is a movement to deploy evidence-based practices (EBPs) developed in research settings into community settings. Training clinicians in EBPs is often used as the primary implementation strategy in these efforts, despite evidence suggesting that training alone does not change therapist behavior. A promising implementation strategy that can be combined with training is consultation, or ongoing support. This paper reviews the literature on consultation following initial training. A model of consultation is presented as well as preliminary findings regarding effective consultation techniques. Future directions are offered. PMID:24072959

  15. 37 CFR 1.115 - Preliminary amendments.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... amendment unduly interferes with the preparation of a first Office action in an application. Factors that... first Office action as of the date of receipt (§ 1.6) of the preliminary amendment by the Office; and... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Preliminary amendments. 1.115...

  16. 37 CFR 1.115 - Preliminary amendments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... amendment unduly interferes with the preparation of a first Office action in an application. Factors that... first Office action as of the date of receipt (§ 1.6) of the preliminary amendment by the Office; and... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Preliminary amendments. 1.115...

  17. 37 CFR 1.115 - Preliminary amendments.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... amendment unduly interferes with the preparation of a first Office action in an application. Factors that... first Office action as of the date of receipt (§ 1.6) of the preliminary amendment by the Office; and... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Preliminary amendments. 1.115...

  18. 32 CFR 1801.11 - Preliminary information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Preliminary information. 1801.11 Section 1801.11... RIGHTS UNDER THE PRIVACY ACT OF 1974 Filing Of Privacy Act Requests § 1801.11 Preliminary information... outstanding fees for information services at this or other federal agencies will not be accepted and action on...

  19. The Survey of Fires in Buildings. Third Report: The Use of Information Obtained From Fire Surveys

    NASA Technical Reports Server (NTRS)

    Silcock, A.

    1973-01-01

    The previous two reports in this series gave details of the general. scope of the pilot exercise and methods by which it was carried out. In addition the nature of the information obtained was illustrated by preliminary analyses of the house and industrial fires surveyed. Some brief comments on the use of the information were made. This report indicates a method of assessing the nation wide effects of applying conclusions drawn from the results of limited numbers of surveys and considers the use of the information for specific purposes.

  20. The Anaclitic-Introjective Depression Assessment: Development and preliminary validity of an observer-rated measure.

    PubMed

    Rost, Felicitas; Luyten, Patrick; Fonagy, Peter

    2018-03-01

    The two-configurations model developed by Blatt and colleagues offers a comprehensive conceptual and empirical framework for understanding depression. This model suggests that depressed patients struggle, at different developmental levels, with issues related to dependency (anaclitic issues) or self-definition (introjective issues), or a combination of both. This paper reports three studies on the development and preliminary validation of the Anaclitic-Introjective Depression Assessment, an observer-rated assessment tool of impairments in relatedness and self-definition in clinical depression based on the item pool of the Shedler-Westen Assessment Procedure. Study 1 describes the development of the measure using expert consensus rating and Q-methodology. Studies 2 and 3 report the assessment of its psychometric properties, preliminary reliability, and validity in a sample of 128 patients diagnosed with treatment-resistant depression. Four naturally occurring clusters of depressed patients were identified using Q-factor analysis, which, overall, showed meaningful and theoretically expected relationships with anaclitic/introjective prototypes as formulated by experts, as well as with clinical, social, occupational, global, and relational functioning. Taken together, findings reported in this paper provide preliminary evidence for the reliability and validity of the Anaclitic-Introjective Depression Assessment, an observer-rated measure that allows the detection of important nuanced differentiations between and within anaclitic and introjective depression. Copyright © 2017 John Wiley & Sons, Ltd.

  1. Evidence of glycemia-lowering effect by a Cynara scolymus L. extract in normal and obese rats.

    PubMed

    Fantini, Noemi; Colombo, Giancarlo; Giori, Andrea; Riva, Antonella; Morazzoni, Paolo; Bombardelli, Ezio; Carai, Mauro A M

    2011-03-01

    Several recent preliminary clinical studies have suggested that artichoke (Cynara scolymus L., Asteraceae family) preparations may be capable of lowering post-prandial glycemia. The present study was designed to test this hypothesis in laboratory rats. To this aim, non-selected Wistar and genetically obese Zucker rats were treated acutely with a purified extract of Cynara scolymus flowering heads (500-1500 mg/kg by gavage) immediately prior to 1 h access to a fixed amount of food. Glycemia was recorded 60, 120 and 360 min after food presentation. Treatment with Cynara scolymus flowering head extract resulted in a significant decrease of post-prandial glycemia in both rat strains. The lack of any fiber content in this Cynara scolymus flowering head extract excludes the involvement of dietary fibers in glycemia reduction. The results obtained constitute the first evidence of a hypoglycemic effect of an artichoke preparation in laboratory rodents and confirm previous observations made in humans. Copyright © 2010 John Wiley & Sons, Ltd.

  2. Exercise and physical activity in mental disorders: clinical and experimental evidence.

    PubMed

    Zschucke, Elisabeth; Gaudlitz, Katharina; Ströhle, Andreas

    2013-01-01

    Several epidemiological studies have shown that exercise (EX) and physical activity (PA) can prevent or delay the onset of different mental disorders, and have therapeutic benefits when used as sole or adjunct treatment in mental disorders. This review summarizes studies that used EX interventions in patients with anxiety, affective, eating, and substance use disorders, as well as schizophrenia and dementia/mild cognitive impairment. Despite several decades of clinical evidence with EX interventions, controlled studies are sparse in most disorder groups. Preliminary evidence suggests that PA/EX can induce improvements in physical, subjective and disorder-specific clinical outcomes. Potential mechanisms of action are discussed, as well as implications for psychiatric research and practice.

  3. Developing empowering health counseling measurement. Preliminary results.

    PubMed

    Kettunen, Tarja; Liimatainen, Leena; Villberg, Jari; Perko, Ulla

    2006-12-01

    This article describes the derivation of an instrument (Empowering Speech Practices Scale) for assessing the empowerment of dyadic counseling, the evaluation of the validity and reliability of the ESPS and the results acquired with the instrument from hospital counseling. ESPS was constructed on the basis of empowerment theory and foregoing conversation analytic research. Nurses and patients assessed the same counseling session by way of parallel statements. Structure and reliability of the scale were evaluated with Cronbach alpha, percentage of agreement, factor analysis and logistic regression analysis. According to these preliminary results, ESPS described the realization of empowerment, directing attention to patient participation. By means of the scale, we assessed 127 counseling sessions and found evidence of the realization of empowering counseling. According to the results, nurses were the most successful in constructing a positive emotional atmosphere and in giving information. We found evidence that nurses need to improve the active mutuality of the counseling relationship by asking for patients' opinions and views, by facilitating the patients' assessment of their personal health and their participation in decision-making and coming up with options for their individual treatment. The developed scale can be utilized, in addition to assessing the quality in hospital care, for improving nursing education programs. Further study is needed to evaluate the usability of the scale and to examine its stability and validity.

  4. Brayton cycle heat exchanger and duct assembly (HXDA, preliminary design and technology tests

    NASA Technical Reports Server (NTRS)

    Coombs, M. G.; Morse, C. J.; Graves, R. F.; Gibson, J. C.

    1972-01-01

    A preliminary design of the heat exchanger and duct assembly (HXDA) for a 60 kwe, closed loop, Brayton cycle space power system is presented. This system is weight optimized within the constraints imposed by the defined structural and operational requirements. Also presented are the results of several small scale tests, directed to obtaining specific design data and/or the resolution of a design approach for long life Brayton cycle heat exchanger systems.

  5. Modeling the complete Otto cycle: Preliminary version. [computer programming

    NASA Technical Reports Server (NTRS)

    Zeleznik, F. J.; Mcbride, B. J.

    1977-01-01

    A description is given of the equations and the computer program being developed to model the complete Otto cycle. The program incorporates such important features as: (1) heat transfer, (2) finite combustion rates, (3) complete chemical kinetics in the burned gas, (4) exhaust gas recirculation, and (5) manifold vacuum or supercharging. Changes in thermodynamic, kinetic and transport data as well as model parameters can be made without reprogramming. Preliminary calculations indicate that: (1) chemistry and heat transfer significantly affect composition and performance, (2) there seems to be a strong interaction among model parameters, and (3) a number of cycles must be calculated in order to obtain steady-state conditions.

  6. A preliminary design of the collinear dielectric wakefield accelerator

    NASA Astrophysics Data System (ADS)

    Zholents, A.; Gai, W.; Doran, S.; Lindberg, R.; Power, J. G.; Strelnikov, N.; Sun, Y.; Trakhtenberg, E.; Vasserman, I.; Jing, C.; Kanareykin, A.; Li, Y.; Gao, Q.; Shchegolkov, D. Y.; Simakov, E. I.

    2016-09-01

    A preliminary design of the multi-meter long collinear dielectric wakefield accelerator that achieves a highly efficient transfer of the drive bunch energy to the wakefields and to the witness bunch is considered. It is made from 0.5 m long accelerator modules containing a vacuum chamber with dielectric-lined walls, a quadrupole wiggler, an rf coupler, and BPM assembly. The single bunch breakup instability is a major limiting factor for accelerator efficiency, and the BNS damping is applied to obtain the stable multi-meter long propagation of a drive bunch. Numerical simulations using a 6D particle tracking computer code are performed and tolerances to various errors are defined.

  7. A preliminary typology of caregivers and effects on service utilization of caregiver counseling.

    PubMed

    Pepin, Renee; Williams, Ashley A; Anderson, Lindsay N; Qualls, Sara H

    2013-01-01

    Caregivers (CGs) of older adults have unique and diverse needs for intervention. The present studies describe the characteristics of CGs and caregiving situations and how these relate to CG therapy utilization patterns in a community mental health setting. Study 1: Through chart review, the researchers explored service utilization patterns and identified preliminary typologies of Caregiver Family Therapy (CFT) clients, N = 23. Study 2: By conducting a second chart review, the researchers sought to determine whether the categories that emerged in Study 1 applied to a second group of CFT clients, N = 36. Study 1: Four distinct categories of CGs emerged: High-Distress (high disorganization, high complexity), Resourceful but At-Risk (low disorganization, high complexity), Non-Committal (high disorganization, low complexity), and Model CGs (low disorganization, low complexity). Study 2: While the ability to classify CGs into category proved to have some inconsistencies, preliminary evidence suggests the ability to predict utilization once CGs were placed into category was good. In Study 2 a fifth category emerged: High Functioning but Static, which suggests CGs were on a continuum ranging from high to low on family organizational style and CG situation complexity. While caregiving situations vary widely among families and across time, this article provides a preliminary typology of CGs that may assist clinicians in tailoring CG interventions to meet the needs of their clients based on information garnered early in therapy, perhaps as early as the intake process.

  8. A Preliminary Typology of Caregivers and Effects on Service Utilization of Caregiver Counseling

    PubMed Central

    Pepin, Renee; Williams, Ashley A.; Anderson, Lindsay N.; Qualls, Sara H.

    2014-01-01

    Objectives Caregivers (CGs) of older adults have unique and diverse needs for intervention. The present studies describe the characteristics of CGs and caregiving situations and how these relate to CG therapy utilization patterns in a community mental health setting. Method Study 1: Through chart review, the researchers explored service utilization patterns and identified preliminary typologies of Caregiver Family Therapy (CFT) clients, N = 23. Study 2: By conducting a second chart review, the researchers sought to determine whether the categories that emerged in Study 1 applied to a second group of CFT clients, N = 36. Results Study 1: Four distinct categories of caregivers emerged: High-Distress (high disorganization, high complexity), Resourceful but At-Risk (low disorganization, high complexity), Non-Committal (high disorganization, low complexity), and Model CGs (low disorganization, low complexity). Study 2: While the ability to classify CGs into category proved to have some inconsistencies, preliminary evidence suggests the ability to predict utilization once CGs were placed into category was good. In Study 2 a fifth category emerged: High Functioning but Static, which suggests CGs were on a continuum ranging from high to low on family organizational style and CG situation complexity. Conclusion While caregiving situations vary widely among families and across time, this paper provides a preliminary typology of CGs that may assist clinicians in tailoring CG interventions to meet the needs of their clients based on information garnered early in therapy, perhaps as early as the intake process. PMID:23336319

  9. Preliminary Results of Field Emission Cathode Tests

    NASA Technical Reports Server (NTRS)

    Sovey, James S.; Kovaleski, Scott D.

    2001-01-01

    Preliminary screening tests of field emission cathodes such as chemical vapor deposited (CVD) diamond, textured pyrolytic graphite, and textured copper were conducted at background pressures typical of electric thruster test facilities to assess cathode performance and stability. Very low power electric thrusters which provide tens to hundreds micronewtons of thrust may need field emission neutralizers that have a capability of tens to hundreds of microamperes. From current voltage characteristics, it was found that the CVD diamond and textured metals cathodes clearly satisfied the Fowler-Nordheim emission relation. The CVD diamond and a textured copper cathode had average current densities of 270 and 380 mA/sq cm, respectively, at the beginning-of-life. After a few hours of operation the cathode emission currents degraded by 40 to 75% at background pressures in the 10(exp -5) Pa to 10(exp -4) Pa range. The textured pyrolytic graphite had a modest current density at beginning-of-life of 84 mA/sq cm, but this cathode was the most stable of all. Extended testing of the most promising cathodes is warranted to determine if current degradation is a burn-in effect or whether it is a long-term degradation process. Preliminary experiments with ferroelectric emission cathodes, which are ceramics with spontaneous electric polarization, were conducted. Peak current densities of 30 to 120 mA/sq cm were obtained for pulse durations of about 500 ns in the 10(exp -4) Pa pressure range.

  10. 20 CFR 30.905 - How may an impairment evaluation be obtained?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false How may an impairment evaluation be obtained... UNDER THE ENERGY EMPLOYEES OCCUPATIONAL ILLNESS COMPENSATION PROGRAM ACT OF 2000, AS AMENDED Impairment Benefits Under Part E of EEOICPA Medical Evidence of Impairment § 30.905 How may an impairment evaluation...

  11. The Viking biological investigation - Preliminary results

    NASA Technical Reports Server (NTRS)

    Klein, H. P.; Oyama, V. I.; Berdahl, B. J.; Horowitz, N. H.; Hobby, G. L.; Levin, G. V.; Straat, P. A.; Lederberg, J.; Rich, A.; Hubbard, J. S.

    1976-01-01

    A preliminary progress report is presented for the Viking biological investigation through its first month. The carbon assimilation, gas exchange, and labeled release experiments are described in detail, and the chronology of the experiments is outlined. For the first experiment, it is found that a small amount of gas was converted into organic material in one sample and that heat treatment of a duplicate sample prevented such conversion. In the second experiment, a substantial amount of O2 was detected along with significant increases in CO2 and small changes in N2. In the third experiment, a significant amount of radioactive gas was evolved from one sample, but not from a duplicate heat-treated sample. Possible biological and nonbiological interpretations are considered for these results. It is concluded that while the experiments provide clear evidence for the occurrence of chemical reactions and while the results do not violate any prima facie criteria for biological processes, a definitive answer cannot yet be given to the question of whether life exists on Mars.

  12. Building Bridges to the Economic Mainstream for African American Male Ex-Offenders: A Preliminary Assessment of an Inmate Education Re-Entry Program.

    ERIC Educational Resources Information Center

    Johnson, James H., Jr.; Farrell, Walter C., Jr.; Braithwaite, Lawrence P.

    This paper describes a state-funded inmate education and re-entry program that provides soft skills training for soon-to-be released offenders. The paper presents preliminary evidence regarding the impact of this training on 14 young male participants. Data came from information prepared by inmates throughout the training program and ethnographic…

  13. Magnetic Field Observations near Mercury: Preliminary Results from Mariner 10.

    PubMed

    Ness, N F; Behannon, K W; Lepping, R P; Whang, Y C; Schatten, K H

    1974-07-12

    Results are presented from a preliminary analysis of data obtained near Mercury on 29 March 1974 by the NASA-GSFC magnetic field experiment on Mariner 10. Rather unexpectedly, a very well-developed, detached bow shock wave, which develops as the super-Alfvénic solar wind interacts with the planet, has been observed. In addition, a magnetosphere-like region, with maximum field strength of 98 gammas at closest approach (704 kilometers altitude), has been observed, contained within boundaries similar to the terrestrial magnetopause. The obstacle deflecting the solar wind flow is global in size, but the origin of the enhanced magnetic field has not yet been uniquely established. The field may be intrinsic to the planet and distorted by interaction with the solar wind. It may also be associated with a complex induction process whereby the planetary interior-atmosphere-ionosphere interacts with the solar wind flow to generate the observed field by a dynamo action. The complete body of data favors the preliminary conclusion that Mercury has an intrinsic magnetic field. If this is correct, it represents a major scientific discovery in planetary magnetism and will have considerable impact on studies of the origin of the solar system.

  14. Increasing correlations between personality traits and cortisol stress responses obtained by data aggregation.

    PubMed

    Pruessner, J C; Gaab, J; Hellhammer, D H; Lintz, D; Schommer, N; Kirschbaum, C

    1997-11-01

    Attempts to link personality traits and cortisol stress responses have often been inconclusive. The aim of this paper was to investigate this association by aggregating cortisol stress responses. Therefore, 20 healthy men were exposed to a task consisting of public speaking and mental arithmetics in front of an audience on five days. Six cortisol levels were measured in relation to the stressful task obtained at 10-min intervals on each day. Psychological assessment included the Questionnaire for Competence and Control (FKK) and the Giessen-Test (G-T). These questionnaires focus on assessing personality traits, i.e. locus of control and self-concept. Areas under the response curve (AUC) of the six cortisol samples were computed to obtain an index of the individual's cortisol stress response on each day. Since novelty is a random situational factor likely to mask individual differences in the stress response, the AUC cortisol stress responses of days two to five were consecutively aggregated, excluding the first day. Scales of the two questionnaires employed did not correlate with the AUC cortisol stress response of the first stress trial. The correlation pattern of the AUC cortisol measures of days two to five with the questionnaire scales was inconclusive. However, significant correlations emerged with an increasing number of cortisol stress responses aggregated. Correlations between the measure of social dominance and aggregated AUC cortisol stress responses rose from r = -.47 on day two of the experimental session to r = -.70 after aggregating days two to five. Similarly, measures of locus of control and cortisol stress responses became increasingly correlated with aggregation of several stress exposures. These data provide preliminary evidence for a relationship between questionnaire scales aiming at assessing personality traits and cortisol stress responses uncovered by repeated stress exposure and data aggregation. While novelty may mask the impact of

  15. Preliminary results of investigations into the use of artificial neural networks for discriminating gas chromatograph mass spectra of remote samples

    NASA Technical Reports Server (NTRS)

    Geller, Harold A.; Norris, Eugene; Warnock, Archibald, III

    1991-01-01

    Neural networks trained using mass spectra data from the National Institute of Standards and Technology (NIST) are studied. The investigations also included sample data from the gas chromatograph mass spectrometer (GCMS) instrument aboard the Viking Lander, obtained from the National Space Science Data Center. The work performed to data and the preliminary results from the training and testing of neural networks are described. These preliminary results are presented for the purpose of determining the viability of applying artificial neural networks in discriminating mass spectra samples from remote instrumentation such as the Mars Rover Sample Return Mission and the Cassini Probe.

  16. Evidence from the Cochrane Collaboration for Traditional Chinese Medicine Therapies

    PubMed Central

    Wieland, Susan; Kimbrough, Elizabeth; Cheng, Ker; Berman, Brian M.

    2009-01-01

    Abstract Background The Cochrane Collaboration, an international not-for-profit organization that prepares and maintains systematic reviews of randomized trials of health care therapies, has produced reviews summarizing much of the evidence on Traditional Chinese Medicine (TCM). Our objective was to review the evidence base according to Cochrane systematic reviews. Methods In order to detect reviews focusing on TCM, we searched the titles and abstracts of all reviews in Issue 4, 2008 of the Cochrane Database of Systematic Reviews. For each review, we extracted data on the number of trials included and the total number of participants. We provided an indication of the strength of the review findings by assessing the reviewers' abstract conclusions statement. We supplemented our assessment of the abstract conclusions statements with a listing of the comparisons and outcomes showing statistically significant meta-analyses results. Results We identified 70 Cochrane systematic reviews of TCM, primarily acupuncture (n = 26) and Chinese herbal medicine (n = 42), and 1 each of moxibustion and t'ai chi. Nineteen (19) of 26 acupuncture reviews and 22/42 herbal medicine reviews concluded that there was not enough good quality trial evidence to make any conclusion about the efficacy of the evaluated treatment, while the remaining 7 acupuncture and 20 herbal medicine reviews and each of the moxibustion and t'ai chi reviews indicated a suggestion of benefit, which was qualified by a caveat about the poor quality and quantity of studies. Most reviews included many distinct interventions, controls, outcomes, and populations, and a large number of different comparisons were made, each with a distinct forest plot. Conclusions Most Cochrane systematic reviews of TCM are inconclusive, due specifically to the poor methodology and heterogeneity of the studies reviewed. Some systematic reviews provide preliminary evidence of Chinese medicine's benefits to certain patient populations

  17. Preliminary analysis of STS-2 entry flight data

    NASA Technical Reports Server (NTRS)

    1982-01-01

    A preliminary analysis of the data obtained during the entry of the STS-2 flight was completed. The stability and control derivatives from STS-2 were examined. Questions still remain throughout the flight envelope and the area below Mach 3 needs more study. With three controls operating in a high gain feedback system, it is difficult to separate the individual effects of each of the controls. Analysis of the aerothermal data shows that wing structural-temperature measurements are generally repeatable and consistent with the trajectories. The measured wing upper surface temperatures are in reasonable agreement with Dryden predictions but wing lower surface temperatures are higher than Dryden predictions. Heating and heat transfer models will be adjusted to improve the temperature prediction capability for future trajectories.

  18. Preliminary Results of an Altitude-Wind-Tunnel Investigation of an Axial-Flow Gas Turbine-Propeller Engine. 1; Performance Characteristics

    NASA Technical Reports Server (NTRS)

    Saari, Martin J.; Wallner, Lewis E.

    1948-01-01

    A preliminary investigation of an axial-flow gas turbine-propeller engine was conduxted. Performance data were obtained for engine speeds from 8000 to 13,000 rpm and altitudes from 5000 to 35,000 feet and compressor inlet ram pressure ratios from 1.00 to 1.17.

  19. 46 CFR 71.50-21 - Preliminary examination requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... exclusively use divers to examine the underwater hull plating, you must arrange to have a preliminary... the predominant means to examine your vessel's hull plating, a preliminary examination and the...

  20. 46 CFR 176.635 - Preliminary examination requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Preliminary examination requirements. 176.635 Section... (UNDER 100 GROSS TONS) INSPECTION AND CERTIFICATION Hull and Tailshaft Examinations § 176.635 Preliminary examination requirements. (a) If you exclusively use divers to examine the underwater hull plating, you must...

  1. Teacher Self-Assessment of Evidence-Based Classroom Practices: Preliminary Findings across Primary, Intermediate and Secondary Level Teachers

    ERIC Educational Resources Information Center

    Borgmeier, Chris; Loman, Sheldon L.; Hara, Motoaki

    2016-01-01

    The limited implementation of evidence-based classroom practices and ways to provide effective professional development to address this challenge remain enduring concerns in education. Despite these concerns, there exists a well-established research literature on evidence-based practices for effective classroom management and instructional…

  2. An optimized procedure for obtaining DNA from fired and unfired ammunition.

    PubMed

    Montpetit, Shawn; O'Donnell, Patrick

    2015-07-01

    Gun crimes are a significant problem facing law enforcement agencies. Traditional forensic examination of firearms involves comparisons of markings imparted to bullets and cartridge casings during the firing process. DNA testing of casings and cartridges may not be routinely done in crime laboratories due a variety of factors including the typically low amounts of DNA recovered. The San Diego Police Department (SDPD) Crime Laboratory conducted a study to optimize the collection and profiling of DNA from fired and unfired ammunition. The method was optimized to where interpretable DNA results were obtained for 26.1% of the total number of forensic casework evidence samples, and provided some insights into the level of secondary transfer that might be expected from this type of evidence. Briefly detailed are the results from the experimental study and the forensic casework analysis using the optimized process. Mixtures (samples having more DNA types than the loader's known genotype detected or visible at any marker) were obtained in 39.8% of research samples and the likely source of DNA mixtures is discussed. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  3. 14 CFR 150.31 - Preliminary review: Acknowledgments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... program submitted under § 150.23, the Regional Airports Division Manager acknowledges to the airport... preliminary review, the Regional Airports Division Manager finds that the submission does not conform to the... reconsideration and development of a program in accordance with this part. (c) If, based on the preliminary review...

  4. 33 CFR 1.07-25 - Preliminary matters.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Preliminary matters. 1.07-25 Section 1.07-25 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL GENERAL PROVISIONS Enforcement; Civil and Criminal Penalty Proceedings § 1.07-25 Preliminary matters. (a...

  5. 33 CFR 1.07-25 - Preliminary matters.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Preliminary matters. 1.07-25 Section 1.07-25 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL GENERAL PROVISIONS Enforcement; Civil and Criminal Penalty Proceedings § 1.07-25 Preliminary matters. (a...

  6. 33 CFR 1.07-25 - Preliminary matters.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Preliminary matters. 1.07-25 Section 1.07-25 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL GENERAL PROVISIONS Enforcement; Civil and Criminal Penalty Proceedings § 1.07-25 Preliminary matters. (a...

  7. 33 CFR 1.07-25 - Preliminary matters.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Preliminary matters. 1.07-25 Section 1.07-25 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL GENERAL PROVISIONS Enforcement; Civil and Criminal Penalty Proceedings § 1.07-25 Preliminary matters. (a...

  8. 33 CFR 1.07-25 - Preliminary matters.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Preliminary matters. 1.07-25 Section 1.07-25 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL GENERAL PROVISIONS Enforcement; Civil and Criminal Penalty Proceedings § 1.07-25 Preliminary matters. (a...

  9. Effect of different methods of preliminary surface treatment and magnetron sputtering on the adhesion of Si coatings

    NASA Astrophysics Data System (ADS)

    Borisov, D. P.; Slabodchikov, V. A.; Kuznetsov, V. M.

    2017-05-01

    The paper presents research results on the adhesion of Si coatings deposited by magnetron sputtering on NiTi substrates after preliminary surface treatment (cleaning and activation) with low-energy ion beams and gas discharge plasma. The adhesion properties of the coatings obtained by two methods are analyzed and compared using data of scratch and spherical abrasion tests.

  10. Preliminary Computational Analysis of the (HIRENASD) Configuration in Preparation for the Aeroelastic Prediction Workshop

    NASA Technical Reports Server (NTRS)

    Chwalowski, Pawel; Florance, Jennifer P.; Heeg, Jennifer; Wieseman, Carol D.; Perry, Boyd P.

    2011-01-01

    This paper presents preliminary computational aeroelastic analysis results generated in preparation for the first Aeroelastic Prediction Workshop (AePW). These results were produced using FUN3D software developed at NASA Langley and are compared against the experimental data generated during the HIgh REynolds Number Aero- Structural Dynamics (HIRENASD) Project. The HIRENASD wind-tunnel model was tested in the European Transonic Windtunnel in 2006 by Aachen University0s Department of Mechanics with funding from the German Research Foundation. The computational effort discussed here was performed (1) to obtain a preliminary assessment of the ability of the FUN3D code to accurately compute physical quantities experimentally measured on the HIRENASD model and (2) to translate the lessons learned from the FUN3D analysis of HIRENASD into a set of initial guidelines for the first AePW, which includes test cases for the HIRENASD model and its experimental data set. This paper compares the computational and experimental results obtained at Mach 0.8 for a Reynolds number of 7 million based on chord, corresponding to the HIRENASD test conditions No. 132 and No. 159. Aerodynamic loads and static aeroelastic displacements are compared at two levels of the grid resolution. Harmonic perturbation numerical results are compared with the experimental data using the magnitude and phase relationship between pressure coefficients and displacement. A dynamic aeroelastic numerical calculation is presented at one wind-tunnel condition in the form of the time history of the generalized displacements. Additional FUN3D validation results are also presented for the AGARD 445.6 wing data set. This wing was tested in the Transonic Dynamics Tunnel and is commonly used in the preliminary benchmarking of computational aeroelastic software.

  11. Conversion of the Aerodynamic Preliminary Analysis System (APAS) to an IBM PC Compatible Format

    NASA Technical Reports Server (NTRS)

    Kruep, John M.

    1995-01-01

    The conversion of the Aerodynamic Preliminary Analysis System (APAS) software from a Silicon Graphics UNIX-based platform to a DOS-based IBM PC compatible is discussed. Relevant background information is given, followed by a discussion of the steps taken to accomplish the conversion and a discussion of the type of problems encountered during the conversion. A brief comparison of aerodynamic data obtained using APAS with data from another source is also made.

  12. Influence of Articulating Paper Thickness on Occlusal Contacts Registration: A Preliminary Report.

    PubMed

    Brizuela-Velasco, Aritza; Álvarez-Arenal, Ángel; Ellakuria-Echevarria, Joseba; del Río-Highsmith, Jaime; Santamaría-Arrieta, Gorka; Martín-Blanco, Nerea

    2015-01-01

    The objective of this preliminary study was to determine if the occlusal contact surface registered with an articulating paper during fixed prosthodontic treatment was contained within the area marked on a thicker articulating paper. This information would optimize any necessary occlusal adjustment of a prosthesis' veneering material. A convenience sample of 15 patients who were being treated with an implant-supported fixed singleunit dental prosthesis was selected. Occlusal registrations were obtained from each patient using 12-μm, 40-μm, 80-μm, and 200-μm articulating paper. Photographs of the occlusal registrations were obtained, and pixel measurements of the surfaces were taken and overlapped for comparison. The results showed that the thicker the articulating paper, the larger the occlusal contact area obtained. The differences were statistically significant. In all cases, the occlusal registrations obtained with the thinnest articulating paper were contained within the area marked on the thickest articulating paper. The results suggested that the use of thin articulating papers (12-μm or 40-μm) can avoid unnecessary grinding of veneering material or teeth during occlusal adjustment.

  13. 7 CFR 1780.55 - Preliminary engineering reports and Environmental Reports.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 12 2011-01-01 2011-01-01 false Preliminary engineering reports and Environmental..., Designing, Bidding, Contracting, Constructing and Inspections § 1780.55 Preliminary engineering reports and Environmental Reports. Preliminary engineering reports (PERs) must conform to customary professional standards...

  14. 7 CFR 1780.55 - Preliminary engineering reports and Environmental Reports.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 12 2012-01-01 2012-01-01 false Preliminary engineering reports and Environmental..., Designing, Bidding, Contracting, Constructing and Inspections § 1780.55 Preliminary engineering reports and Environmental Reports. Preliminary engineering reports (PERs) must conform to customary professional standards...

  15. 7 CFR 1780.55 - Preliminary engineering reports and Environmental Reports.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 12 2014-01-01 2013-01-01 true Preliminary engineering reports and Environmental..., Designing, Bidding, Contracting, Constructing and Inspections § 1780.55 Preliminary engineering reports and Environmental Reports. Preliminary engineering reports (PERs) must conform to customary professional standards...

  16. 7 CFR 1780.55 - Preliminary engineering reports and Environmental Reports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Preliminary engineering reports and Environmental..., Designing, Bidding, Contracting, Constructing and Inspections § 1780.55 Preliminary engineering reports and Environmental Reports. Preliminary engineering reports (PERs) must conform to customary professional standards...

  17. 7 CFR 1780.55 - Preliminary engineering reports and Environmental Reports.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 12 2013-01-01 2013-01-01 false Preliminary engineering reports and Environmental..., Designing, Bidding, Contracting, Constructing and Inspections § 1780.55 Preliminary engineering reports and Environmental Reports. Preliminary engineering reports (PERs) must conform to customary professional standards...

  18. 17 CFR 242.100 - Preliminary note; definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... (CONTINUED) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY FUTURES Regulation M § 242.100 Preliminary note; definitions. (a) Preliminary note: Any transaction or series of transactions, whether or not effected pursuant to the provisions of Regulation M (§§ 242.100-242.105 of this...

  19. 18 CFR 1b.6 - Preliminary investigations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Preliminary investigations. 1b.6 Section 1b.6 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.6 Preliminary investigations. The...

  20. 18 CFR 1b.6 - Preliminary investigations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Preliminary investigations. 1b.6 Section 1b.6 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.6 Preliminary investigations. The...

  1. 18 CFR 1b.6 - Preliminary investigations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Preliminary investigations. 1b.6 Section 1b.6 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.6 Preliminary investigations. The...

  2. 18 CFR 1b.6 - Preliminary investigations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Preliminary investigations. 1b.6 Section 1b.6 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.6 Preliminary investigations. The...

  3. Health Sciences-Evidence Based Practice questionnaire (HS-EBP) for measuring transprofessional evidence-based practice: Creation, development and psychometric validation.

    PubMed

    Fernández-Domínguez, Juan Carlos; de Pedro-Gómez, Joan Ernest; Morales-Asencio, José Miguel; Bennasar-Veny, Miquel; Sastre-Fullana, Pedro; Sesé-Abad, Albert

    2017-01-01

    Most of the EBP measuring instruments available to date present limitations both in the operationalisation of the construct and also in the rigour of their psychometric development, as revealed in the literature review performed. The aim of this paper is to provide rigorous and adequate reliability and validity evidence of the scores of a new transdisciplinary psychometric tool, the Health Sciences Evidence-Based Practice (HS-EBP), for measuring the construct EBP in Health Sciences professionals. A pilot study and a subsequent two-stage validation test sample were conducted to progressively refine the instrument until a reduced 60-item version with a five-factor latent structure. Reliability was analysed through both Cronbach's alpha coefficient and intraclass correlations (ICC). Latent structure was contrasted using confirmatory factor analysis (CFA) following a model comparison aproach. Evidence of criterion validity of the scores obtained was achieved by considering attitudinal resistance to change, burnout, and quality of professional life as criterion variables; while convergent validity was assessed using the Spanish version of the Evidence-Based Practice Questionnaire (EBPQ-19). Adequate evidence of both reliability and ICC was obtained for the five dimensions of the questionnaire. According to the CFA model comparison, the best fit corresponded to the five-factor model (RMSEA = 0.049; CI 90% RMSEA = [0.047; 0.050]; CFI = 0.99). Adequate criterion and convergent validity evidence was also provided. Finally, the HS-EBP showed the capability to find differences between EBP training levels as an important evidence of decision validity. Reliability and validity evidence obtained regarding the HS-EBP confirm the adequate operationalisation of the EBP construct as a process put into practice to respond to every clinical situation arising in the daily practice of professionals in health sciences (transprofessional). The tool could be useful for EBP individual

  4. Kinetic Roughening and Energetics of Tetragonal Lysozyme Crystal Growth: A Preliminary Atomic Force Microscopy Investigation

    NASA Technical Reports Server (NTRS)

    Gorti, Sridhar; Forsythe, Elizabeth L.; Pusey, Marc L.

    2004-01-01

    We examined particulars of crystal growth from measurements obtained at both microscopic and molecular levels. The crystal growth measurements performed at the microscopic level are well characterized by a model that balances the flux of macromolecules towards the crystal surface with the flux of the crystal surface. Numerical evaluation of model with measurements of crystal growth, in time, provided accurate estimates for the average growth velocities. Growth velocities thus obtained were also interpreted using well-established phenomenological theories. Moreover, we find that microscopic measurements of growth velocity measurements obtained as a function of temperature best characterizes changes in crystal growth modes, when present. We also examined the possibility of detecting a change in crystal growth modes at the molecular level using atomic force microscopy, AFM. From preliminary AFM measurements performed at various supersaturations, we find that magnitude of surface height fluctuations, h(x), increases with supersaturation. Further examination of surface height fluctuations using methods established for fluctuation spectroscopy also enabled the discovery of the existence of a characteristic length, c, which may possibly determine the mode of crystal growth. Although the results are preliminary, we establish the non- critical divergence of 5 and the root-mean-square (rms) magnitude of height-height fluctuations as the kinetic roughening transition temperatures are approached. Moreover, we also examine approximate models for interpreting the non-critical behavior of both 6 and rms magnitude of height-height fluctuations, as the solution supersaturation is increased towards the kinetic roughening supersaturation.

  5. Preliminary design of a high speed civil transport: The Opus 0-001

    NASA Technical Reports Server (NTRS)

    1992-01-01

    Based on research into the technology and issues surrounding the design, development, and operation of a second generation High Speed Civil Transport, HSCT, the Opus 0-001 team completed the preliminary design of a sixty passenger, three engine aircraft. The design of this aircraft was performed using a computer program which the team wrote. This program automatically computed the geometric, aerodynamic, and performance characteristic of an aircraft whose preliminary geometry was specified. The Opus 0-001 aircraft was designed for a cruise Mach number of 2.2, a range of 4,700 nautical miles and its design was based in current or very near term technology. Its small size was a consequence of an emphasis on a profitable, low cost program, capable of delivering tomorrow's passengers in style and comfort at prices that make it an attractive competitor to both current and future subsonic transport aircraft. Several hundred thousand cases of Cruise Mach number, aircraft size and cost breakdown were investigated to obtain costs and revenues for which profit was calculated. The projected unit flyaway cost was $92.0 million per aircraft.

  6. Levels of Evidence: Adult and Pediatric Treatment Studies (PDQ®)—Health Professional Version

    Cancer.gov

    Levels of evidence refers to the ranking system used by the PDQ editorial boards to indicate the strength of evidence obtained from cited studies. Get detailed information about how to weigh the strength of the evidence obtained in cancer treatment studies in this information summary.

  7. The research-design interaction: lessons learned from an evidence-based design studio.

    PubMed

    Haq, Saif; Pati, Debajyoti

    2010-01-01

    As evidence-based design (EBD) emerges as a model of design practice, considerable attention has been given to its research component. However, this overshadows another essential component of EBD-the change agent, namely the designer. EBD introduced a new skill set to the practitioner: the ability to interact with scientific evidence. Industry sources suggest adoption of the EBD approach across a large number of design firms. How comfortable are these designers in integrating research with design decision making? Optimizing the interaction between the primary change agent (the designer) and the evidence is crucial to producing the desired outcomes. Preliminary to examining this question, an architectural design studio was used as a surrogate environment to examine how designers interact with evidence. Twelve students enrolled in a healthcare EBD studio during the spring of 2009. A three-phase didactic structure was adopted: knowing a hospital, knowing the evidence, and designing with knowledge and evidence. Products of the studio and questionnaire responses from the students were used as the data for analysis. The data suggest that optimization of the research-design relationship warrants consideration in four domains: (1) a knowledge structure that is easy to comprehend; (2) phase-complemented representation of evidence; (3) access to context and precedence information; and (4) a designer-friendly vocabulary.

  8. Preliminary analysis of cross beam data from the Gun Barrel Hill site

    NASA Technical Reports Server (NTRS)

    Sandborn, V. A.; Bice, A. R.; Cliff, W. C.; Hablutzel, B. C.

    1974-01-01

    Preliminary evaluation of cross beam data taken at the Gun Barrell Hill test site of ESSA is presented. The evaluation is made using the analog Princeton Time Correlator. A study of the frequency band width limitations of the Princeton Time Correlator is made. Based on the band width limitations, it is possible to demonstrate that nearly identical correlation is obtained for frequencies from .01 to 3.9 hertz. Difficulty is encountered in that maximums in the correlation curves do not occur at zero time lag for zero beam separations.

  9. Verification of EPA's " Preliminary remediation goals for radionuclides" (PRG) electronic calculator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stagich, B. H.

    The U.S. Environmental Protection Agency (EPA) requested an external, independent verification study of their “Preliminary Remediation Goals for Radionuclides” (PRG) electronic calculator. The calculator provides information on establishing PRGs for radionuclides at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) sites with radioactive contamination (Verification Study Charge, Background). These risk-based PRGs set concentration limits using carcinogenic toxicity values under specific exposure conditions (PRG User’s Guide, Section 1). The purpose of this verification study is to ascertain that the computer codes has no inherit numerical problems with obtaining solutions as well as to ensure that the equations are programmed correctly.

  10. MISSE-7 MESA Miniaturized Electrostatic Analyzer - Ion Spectra Analysis Preliminary Results

    NASA Astrophysics Data System (ADS)

    Enloe, C. L.; Balthazor, R. L.; McHarg, M. G.; Clark, A. L.; Waite, D.; Wallerstein, A. J.; Wilson, K. A.

    2011-12-01

    The 7th Materials on the International Space Station Experiment (MISSE-7) was launched in November 2009 and retrieved on STS-134 in April 2011. One of the onboard experiments, the Miniaturized Electrostatic Analyzer (MESA), is a small low-cost low-size/weight/power ion and electron spectrometer that was pointed into ram during the majority of the time onboard. Over 800 Mb of data has been obtained by taking spectra every three minutes on-orbit. The data has been analyzed with a novel "parameterizing the parameters" method suitable for on-orbit data analysis using low-cost microcontrollers. Preliminary results are shown.

  11. Preliminary determination of Newtonian gravitational constant with angular acceleration feedback method

    PubMed Central

    Xue, Chao; Quan, Li-Di; Yang, Shan-Qing; Wang, Bing-Peng; Wu, Jun-Fei; Shao, Cheng-Gang; Tu, Liang-Cheng; Milyukov, Vadim; Luo, Jun

    2014-01-01

    This paper describes the preliminary measurement of the Newtonian gravitational constant G with the angular acceleration feedback method at HUST. The apparatus has been built, and preliminary measurement performed, to test all aspects of the experimental design, particularly the feedback function, which was recently discussed in detail by Quan et al. The experimental results show that the residual twist angle of the torsion pendulum at the signal frequency introduces 0.4 ppm to the value of G. The relative uncertainty of the angular acceleration of the turntable is approximately 100 ppm, which is mainly limited by the stability of the apparatus. Therefore, the experiment has been modified with three features: (i) the height of the apparatus is reduced almost by half, (ii) the aluminium shelves were replaced with shelves made from ultra-low expansion material and (iii) a perfect compensation of the laboratory-fixed gravitational background will be carried out. With these improvements, the angular acceleration is expected to be determined with an uncertainty of better than 10 ppm, and a reliable value of G with 20 ppm or below will be obtained in the near future. PMID:25201996

  12. 32 CFR 644.392 - Air Force-preliminary report of excess.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 4 2014-07-01 2013-07-01 true Air Force-preliminary report of excess. 644.392... PROPERTY REAL ESTATE HANDBOOK Disposal Predisposal Action § 644.392 Air Force—preliminary report of excess... Armed Services Committees of the Congress.) When the preliminary real estate disposal directive is...

  13. Preliminary Characterization of Mus musculus–Derived Pathogenic Strains of Leptospira borgpetersenii Serogroup Ballum in a Hamster Model

    PubMed Central

    da Silva, Éverton F.; Félix, Samuel R.; Cerqueira, Gustavo M.; Fagundes, Michel Q.; Neto, Amilton C. P. S.; Grassmann, André A.; Amaral, Marta G.; Gallina, Tiago; Dellagostin, Odir A.

    2010-01-01

    Human and animal leptospirosis caused by Leptospira spp. belonging to serogroup Ballum has increased worldwide in the past decade. We report the isolation and serologic and molecular characterization of four L. borgpetersenii serogroup Ballum isolates obtained from Mus musculus, and preliminary virulence studies. These isolates are useful for diagnosis of leptospirosis and for epidemiologic studies of its virulence and pathogenic mechanisms. PMID:20682877

  14. Remote measurement of water color in coastal waters. [spectral radiance data used to obtain quantitative values for chlorophyll and turbidity

    NASA Technical Reports Server (NTRS)

    Weldon, J. W.

    1973-01-01

    An investigation was conducted to develop procedure to obtain quantitative values for chlorophyll and turbidity in coastal waters by observing the changes in spectral radiance of the backscattered spectrum. The technique under consideration consists of Examining Exotech model 20-D spectral radiometer data and determining which radiance ratios best correlated with chlorophyll and turbidity measurements as obtained from analyses of water samples and sechi visibility readings. Preliminary results indicate that there is a correlation between backscattered light and chlorophyll concentration and secchi visibility. The tests were conducted with the spectrometer mounted in a light aircraft over the Mississippi Sound at altitudes of 2.5K, 2.8K and 10K feet.

  15. A Preliminary Review of Fatigue Among Rail Staff

    PubMed Central

    Fan, Jialin; Smith, Andrew P.

    2018-01-01

    Background: Fatigue is a severe problem in the rail industry, which may jeopardize train crew's health and safety. Nonetheless, a preliminary review of all empirical evidence for train crew fatigue is still lacking. The aim of the present paper is, therefore, to provide a preliminary description of occupational fatigue in the rail industry. This paper reviews the literature with the research question examining the risk factors associated with train crew fatigue, covering both papers published in refereed journals and reports from trade organizations and regulators. It assesses the progress of research on railway fatigue, including research on the main risk factors for railway fatigue, the association between fatigue and railway incidents, and how to better manage fatigue in the railway industry. Methods: Systematic searches were performed in both science and industry databases. The searches considered studies published before August 2017. The main exclusion criterion was fatigue not being directly measured through subjective or objective methods. Results: A total of 31 studies were included in the main review. The causes of fatigue included long working hours, heavy workload, early morning or night shifts, and insufficient sleep. Poor working environment, particular job roles, and individual differences also contributed to fatigue. Conclusion: Fatigue in the rail industry includes most of the features of occupational fatigue, and it is also subject to industry-specific factors. The effect of fatigue on well-being and the fatigued population in the railway industry are still not clear. Future studies can consider associations between occupational risk factors and perceived fatigue by examining the prevalence of fatigue and identifying the potential risk factors in staff within the railway industry. PMID:29867630

  16. Preliminary Correlations of Gravity and Topography from Mars Global Surveyor

    NASA Technical Reports Server (NTRS)

    Zuber, M. T.; Tyler, G. L.; Smith, D. E.; Balmino, G. S.; Johnson, G. L.; Lemoine, F. G.; Neumann, G. A.; Phillips, R. J.; Sjogren, W. L.; Solomon, S. C.

    1999-01-01

    The Mars Global Surveyor (MGS) spacecraft is currently in a 400-km altitude polar mapping orbit and scheduled to begin global mapping of Mars in March of 1999. Doppler tracking data collected in this Gravity Calibration Orbit prior to the nominal mapping mission combined with observations from the MGS Science Phasing Orbit in Spring - Summer 1999 and the Viking and mariner 9 orbiters has led to preliminary high resolution gravity fields. Spherical harmonic expansions have been performed to degree and order 70 and are characterized by the first high spatial resolution coverage of high latitudes. Topographic mapping by the Mars Orbiter Laser Altimeter on MGS is providing measurements of the height of the martian surface with sub-meter vertical resolution and 5-30 m absolute accuracy. Data obtained during the circular mapping phase are expected to provide the first high resolution measurements of surface heights in the southern hemisphere. The combination of gravity and topography measurements provides information on the structure of the planetary interior, i.e. the rigidity and distribution of internal density. The observations can also be used to address the mechanisms of support of surface topography. Preliminary results of correlations of gravity and topography at long planetary wavelengths will be presented and the implications for internal structure will be addressed.

  17. Cognitive-behavioural group therapy versus guided self-help for compulsive buying disorder: a preliminary study.

    PubMed

    Müller, A; Arikian, A; de Zwaan, M; Mitchell, J E

    2013-01-01

    Compulsive buying (CB) is defined as extreme preoccupation with buying/shopping and frequent buying that causes substantial negative psychological, social, occupational and financial consequences. There exists preliminary evidence that group cognitive-behavioural therapy (CBT) is effective in the treatment of CB. The present pilot study made a first attempt to compare group CBT for CB with telephone-guided self-help (GSH). Fifty-six patients were allocated randomly to one of the three conditions: (1) group CBT (n = 22); (2) GSH (n = 20); and (3) a waiting list condition (n = 14). The results indicate that face-to-face group CBT is superior not only to the waiting list condition but also to GSH. Patients who received GSH tended to have more success in overcoming CB compared with the waiting list controls. Given the sample size, the results must be considered as preliminary and further research is needed to address the topic whether GSH also could be a helpful intervention in reducing CB. Copyright © 2011 John Wiley & Sons, Ltd.

  18. Expanding the domains of attitudes towards evidence-based practice: the evidence based practice attitude scale-50.

    PubMed

    Aarons, Gregory A; Cafri, Guy; Lugo, Lindsay; Sawitzky, Angelina

    2012-09-01

    Mental health and social service provider attitudes toward evidence-based practice have been measured through the development and validation of the Evidence-Based Practice Attitude Scale (EBPAS; Aarons, Ment Health Serv Res 6(2):61-74, 2004). Scores on the EBPAS scales are related to provider demographic characteristics, organizational characteristics, and leadership. However, the EBPAS assesses only four domains of attitudes toward EBP. The current study expands and further identifies additional domains of attitudes towards evidence-based practice. A qualitative and quantitative mixed-methods approach was used to: (1) generate items from multiples sources (researcher, mental health program manager, clinician/therapist), (2) identify potential content domains, and (3) examine the preliminary domains and factor structure through exploratory factor analysis. Participants for item generation included the investigative team, a group of mental health program managers (n = 6), and a group of clinicians/therapists (n = 8). For quantitative analyses a sample of 422 mental health service providers from 65 outpatient programs in San Diego County completed a survey that included the new items. Eight new EBPAS factors comprised of 35 items were identified. Factor loadings were moderate to large and internal consistency reliabilities were fair to excellent. We found that the convergence of these factors with the four previously identified evidence-based practice attitude factors (15 items) was small to moderate suggesting that the newly identified factors represent distinct dimensions of mental health and social service provider attitudes toward adopting EBP. Combining the original 15 items with the 35 new items comprises the EBPAS 50-item version (EBPAS-50) that adds to our understanding of provider attitudes toward adopting EBPs. Directions for future research are discussed.

  19. The ability to mentally represent action is associated with low motor ability in children: a preliminary investigation.

    PubMed

    Gabbard, Carl; Caçola, Priscila; Bobbio, Tatiana

    2012-05-01

    Theory and anatomical research suggest that the ability to mentally represent intended actions affect level of execution. This study presents preliminary data examining the association between children's ability to mentally represent action and general motor ability. Children aged 7- to 10 years were assessed for motor imagery ability using a simulation of reach task and motor ability via the Movement ABC-2. Motor ability values, based on percentile rank, ranged from 2 to 91, with a mean of 36. The overall correlation between mental representation and motor ability yielded a moderately positive relationship (r = .39). Interestingly, when looking at motor ability subcategories, only Balance was significant in the model, explaining 20% of the variance. These results provide preliminary evidence that children's motor ability and the ability to mentally represent action are associated in a positive direction. Furthermore, given the results for Balance, we speculate that there are clinical implications regarding work with potentially at-risk children. © 2011 Blackwell Publishing Ltd.

  20. Preliminary floor, seat, and dummy data

    NASA Technical Reports Server (NTRS)

    Cannon, M. R.; Zimmerman, R. E.

    1986-01-01

    According to preliminary examination of the data, out of 179 data channels that were onboard the aircraft in support of the seat experiments, there is data from 168. There was somewhat more severe environment imposed in the structure of the obstacles than by the ground impact. Therefore, both ground impact and obstacle impact are of interest for crashworthiness experiments. Most of the data channels that were studied are fairly consistent with the physical evidence: they show acceleration levels that are reasonable, and in many cases these integrate out to a reasonable velocity change. Finally, from observation thus far, the ground impact did not fail or significantly damage any seat. Nor did any of the energy absorbers in the modified seats extend. The accelerations do not appear high enough and/or energetic enough to cause this to happen. At this time, the onboard films have not been studied; only some videotape have been viewed. Some of the seats were so badly damaged by the fire that any failures which might have occurred were obscured. A close examination of the onboard films using a stop-action projector will allow a more thorough evaluation.

  1. Synthesis, bioactivity and preliminary biocompatibility studies of glasses in the system CaO-MgO-SiO2-Na2O-P2O5-CaF2.

    PubMed

    Tulyaganov, D U; Agathopoulos, S; Valerio, P; Balamurugan, A; Saranti, A; Karakassides, M A; Ferreira, J M F

    2011-02-01

    New compositions of bioactive glasses are proposed in the CaO-MgO-SiO(2)-Na(2)O-P(2)O(5)-CaF(2) system. Mineralization tests with immersion of the investigated glasses in simulated body fluid (SBF) at 37°C showed that the glasses favour the surface formation of hydroxyapatite (HA) from the early stages of the experiments. In the case of daily renewable SBF, monetite (CaHPO(4)) formation competed with the formation of HA. The influence of structural features of the glasses on their mineralization (bioactivity) performance is discussed. Preliminary in vitro experiments with osteoblasts' cell-cultures showed that the glasses are biocompatible and there is no evidence of toxicity. Sintering and devitrification studies of glass powder compacts were also performed. Glass-ceramics with attractive properties were obtained after heat treatment of the glasses at relatively low temperatures (up to 850°C).

  2. Biogeochemical evidence for subsurface hydrocarbon occurrence, Recluse oil field, Wyoming; preliminary results

    USGS Publications Warehouse

    Dalziel, Mary C.; Donovan, Terrence J.

    1980-01-01

    Anomalously high manganese-to-iron ratios occurring in pine needles and sage leaves over the Recluse oil field, Wyoming, suggest effects of petroleum microseepage on the plants. This conclusion is supported by iron and manganese concentrations in soils and carbon and oxygen isotope ratios in rock samples. Seeping hydrocarbons provided reducing conditions sufficient to enable divalent iron and manganese to be organically complexed or adsorbed on solids in the soils. These bound or adsorped elements in the divalent state are essential to plants, and the plants readily assimilate them. The magnitude of the plant anomalies, combined with the supportive isotopic and chemical evidence confirming petroleum leakage, makes a strong case for the use of plants as a biogeochemical prospecting tool.

  3. Plasma brake model for preliminary mission analysis

    NASA Astrophysics Data System (ADS)

    Orsini, Leonardo; Niccolai, Lorenzo; Mengali, Giovanni; Quarta, Alessandro A.

    2018-03-01

    Plasma brake is an innovative propellantless propulsion system concept that exploits the Coulomb collisions between a charged tether and the ions in the surrounding environment (typically, the ionosphere) to generate an electrostatic force orthogonal to the tether direction. Previous studies on the plasma brake effect have emphasized the existence of a number of different parameters necessary to obtain an accurate description of the propulsive acceleration from a physical viewpoint. The aim of this work is to discuss an analytical model capable of estimating, with the accuracy required by a preliminary mission analysis, the performance of a spacecraft equipped with a plasma brake in a (near-circular) low Earth orbit. The simplified mathematical model is first validated through numerical simulations, and is then used to evaluate the plasma brake performance in some typical mission scenarios, in order to quantify the influence of the system parameters on the mission performance index.

  4. 10 CFR 830.206 - Preliminary documented safety analysis.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Preliminary documented safety analysis. 830.206 Section 830.206 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.206 Preliminary documented safety analysis. If construction begins after December 11, 2000, the contractor...

  5. Daily Life Experience and Somatic Symptoms: A Preliminary Report.

    DTIC Science & Technology

    1981-03-01

    AAO7 9 859 STATE UNIV OF NEW YORK AT STONY BROOK FG 5/10 DAILY LIFE EXPERIENCE AND SOMATIC SYMPTOMS: A PRELIMINARY REPOR--ETC(U) MAR 8I A A STONE. J...Experience and Somatic Symptoms: A Preliminary Report Arthur A. Stone Long Island Research Institute and Department of Psychiatry arnd Behavioral...TITLE (and S..,til.) s. ALF - , rlA9OQ COVERED Daily Life Experience and Somatic Symptoms: A Technical p " Preliminary Report, EL..... S. PERFORMING

  6. 40 CFR 154.31 - Notices of Preliminary Determination.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., retail food prices, and otherwise on the agricultural economy. (3) Send the proposed notices and analysis... PROGRAMS SPECIAL REVIEW PROCEDURES Procedures § 154.31 Notices of Preliminary Determination. The Administrator shall prepare a Notice of Preliminary Determination after the close of the comment period on a...

  7. Health benefits of tai chi: What is the evidence?

    PubMed

    Huston, Patricia; McFarlane, Bruce

    2016-11-01

    To summarize the evidence on the health benefits of tai chi. A literature review was conducted on the benefits of tai chi for 25 specific conditions, as well as for general health and fitness, to update a 2014 review of systematic reviews. Systematic reviews and recent clinical trials were assessed and organized into 5 different groups: evidence of benefit as excellent, good, fair, or preliminary, or evidence of no direct benefit. During the past 45 years more than 500 trials and 120 systematic reviews have been published on the health benefits of tai chi. Systematic reviews of tai chi for specific conditions indicate excellent evidence of benefit for preventing falls, osteoarthritis, Parkinson disease, rehabilitation for chronic obstructive pulmonary disease, and improving cognitive capacity in older adults. There is good evidence of benefit for depression, cardiac and stroke rehabilitation, and dementia. There is fair evidence of benefit for improving quality of life for cancer patients, fibromyalgia, hypertension, and osteoporosis. Current evidence indicates no direct benefit for diabetes, rheumatoid arthritis, or chronic heart failure. Systematic reviews of general health and fitness benefits show excellent evidence of benefit for improving balance and aerobic capacity in those with poor fitness. There is good evidence for increased strength in the lower limbs. There is fair evidence for increased well-being and improved sleep. There were no studies that found tai chi worsened a condition. A recent systematic review on the safety of tai chi found adverse events were typically minor and primarily musculoskeletal; no intervention-related serious adverse events have been reported. There is abundant evidence on the health and fitness effects of tai chi. Based on this, physicians can now offer evidence-based recommendations to their patients, noting that tai chi is still an area of active research, and patients should continue to receive medical follow-up for any

  8. Health Sciences-Evidence Based Practice questionnaire (HS-EBP) for measuring transprofessional evidence-based practice: Creation, development and psychometric validation

    PubMed Central

    Fernández-Domínguez, Juan Carlos; de Pedro-Gómez, Joan Ernest; Morales-Asencio, José Miguel; Sastre-Fullana, Pedro; Sesé-Abad, Albert

    2017-01-01

    Introduction Most of the EBP measuring instruments available to date present limitations both in the operationalisation of the construct and also in the rigour of their psychometric development, as revealed in the literature review performed. The aim of this paper is to provide rigorous and adequate reliability and validity evidence of the scores of a new transdisciplinary psychometric tool, the Health Sciences Evidence-Based Practice (HS-EBP), for measuring the construct EBP in Health Sciences professionals. Methods A pilot study and a subsequent two-stage validation test sample were conducted to progressively refine the instrument until a reduced 60-item version with a five-factor latent structure. Reliability was analysed through both Cronbach’s alpha coefficient and intraclass correlations (ICC). Latent structure was contrasted using confirmatory factor analysis (CFA) following a model comparison aproach. Evidence of criterion validity of the scores obtained was achieved by considering attitudinal resistance to change, burnout, and quality of professional life as criterion variables; while convergent validity was assessed using the Spanish version of the Evidence-Based Practice Questionnaire (EBPQ-19). Results Adequate evidence of both reliability and ICC was obtained for the five dimensions of the questionnaire. According to the CFA model comparison, the best fit corresponded to the five-factor model (RMSEA = 0.049; CI 90% RMSEA = [0.047; 0.050]; CFI = 0.99). Adequate criterion and convergent validity evidence was also provided. Finally, the HS-EBP showed the capability to find differences between EBP training levels as an important evidence of decision validity. Conclusions Reliability and validity evidence obtained regarding the HS-EBP confirm the adequate operationalisation of the EBP construct as a process put into practice to respond to every clinical situation arising in the daily practice of professionals in health sciences (transprofessional). The

  9. Magnetic field observations near Mercury: Preliminary results from Mariner 10

    NASA Technical Reports Server (NTRS)

    Ness, N. F.; Behannon, K. W.; Lepping, R. P.; Whang, Y. C.; Schatten, K. H.

    1974-01-01

    Results are presented from a preliminary analysis of data obtained near Mercury by the NASA/GSFC Magnetic Field Experiment on Mariner 10. A very well developed, detached bow shock wave, which developed as the super-Alfvenic solar wind interacted with the planet Mercury was observed. A magnetosphere-like region, with maximum field strength of 98 gamma at closest approach (704 km altitude) was also observed, and was contained within boundaries similar to the terrestrial magnetopause. The obstacle deflecting the solar wind flow was global in size, but the origin of the enhanced magnetic field was not established. The most plausible explanation, considering the complete body of data, favored the conclusion that Mercury has an intrinsic magnetic field.

  10. Preliminary Examination of Sahara 99555: Mineralogy and Experimental Studies of a New Angrite

    NASA Technical Reports Server (NTRS)

    Mikouchi, T.; McKay, G.; Le, L.; Mittlefehldt, D. W.

    2000-01-01

    A 2710 g meteorite, Sahara 99555 (Sah99), was recently recovered from the Sahara and reported to be the 5th angrite. It is the largest angrite ever found and may offer useful information to better understand the unusual petrogeneses of this rare achondrite group. It may also allow us to examine the chronological record of igneous activity in the very early solar system. We obtained a 2.6 g chip of Sah99 and here present a preliminary report of its petrology and mineralogy in conjunction with a crystallization experiment on an analogue composition.

  11. The Thirty Gigahertz Instrument Receiver for the QUIJOTE Experiment: Preliminary Polarization Measurements and Systematic-Error Analysis.

    PubMed

    Casas, Francisco J; Ortiz, David; Villa, Enrique; Cano, Juan L; Cagigas, Jaime; Pérez, Ana R; Aja, Beatriz; Terán, J Vicente; de la Fuente, Luisa; Artal, Eduardo; Hoyland, Roger; Génova-Santos, Ricardo

    2015-08-05

    This paper presents preliminary polarization measurements and systematic-error characterization of the Thirty Gigahertz Instrument receiver developed for the QUIJOTE experiment. The instrument has been designed to measure the polarization of Cosmic Microwave Background radiation from the sky, obtaining the Q, U, and I Stokes parameters of the incoming signal simultaneously. Two kinds of linearly polarized input signals have been used as excitations in the polarimeter measurement tests in the laboratory; these show consistent results in terms of the Stokes parameters obtained. A measurement-based systematic-error characterization technique has been used in order to determine the possible sources of instrumental errors and to assist in the polarimeter calibration process.

  12. Early signs of osteoarthritis in professional ballet dancers: a preliminary study.

    PubMed

    Angioi, Manuela; Maffulli, Gayle D; McCormack, Moira; Morrissey, Dylan; Chan, Otto; Maffulli, Nicola

    2014-09-01

    To investigate a cohort of professional ballet dancers for evidence of early signs of osteoarthritis (OA). One radiologist and 1 orthopedic surgeon specialized in musculoskeletal disorders analyzed magnetic resonance imaging scans independently. University Teaching Hospital. Fifteen professional ballet dancers (4 males and 11 females; age range, 19-36 years) experiencing chronic pain in the hip, knee, spine, ankle, or foot joints. Presence of osteophytes, subchondral sclerosis, joint space narrowing, cysts, and bone marrow changes; the Kellgren and Lawrence scale was used to quantify the knee OA. In the knee, there was thinning and irregularity of the articular cartilage over the medial femoral condyle and bone marrow changes within the lateral femoral condyle. In the hip, there was a loss of joint space and a frayed labrum with deep recess. The first metatarsophalangeal joint showed evidence of osteophytic development. Early signs of OA, in different joints, were present in a small but highly selected cohort of professional ballet dancers. In future, prospective studies among a number of ballet companies should control for medical and natural history alongside the visual analysis of images and plain radiographs to confirm these preliminary results.

  13. 10 CFR 824.6 - Preliminary notice of violation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Preliminary notice of violation. 824.6 Section 824.6 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY VIOLATIONS § 824.6 Preliminary notice of violation. (a) In order to begin a proceeding to...

  14. 10 CFR 824.6 - Preliminary notice of violation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Preliminary notice of violation. 824.6 Section 824.6 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY VIOLATIONS § 824.6 Preliminary notice of violation. (a) In order to begin a proceeding to...

  15. Preliminary investigation of the transmission of tuberculosis between farmers and their cattle in smallholder farms in northwestern Ethiopia: a cross-sectional study.

    PubMed

    Nuru, Anwar; Mamo, Gezahegne; Zewude, Aboma; Mulat, Yitayal; Yitayew, Gashaw; Admasu, Aschalew; Medhin, Girmay; Pieper, Rembert; Ameni, Gobena

    2017-01-07

    The feeding habits and close physical contact between Ethiopian farmers and their cattle promote the transmission of tuberculosis (TB) between the farmers and their cattle. This study aimed to investigate the transmission of TB between farmers and their cattle in smallholder farms in northwestern Ethiopia. A total of 70 human TB lymphadenitis (TBLN) cases visiting the Felegehiwot Comprehensive Specialized Hospital in Bahir Dar City and 660 cattle were investigated. Half of the cattle were owned by households with TB cases, and the remaining half by TB free households. Among the 70 human TBLN patients interviewed, 65.7% (46 out of 70) of the respondents were not aware of zoonotic TB, and 67.1% (47/70) of them consumed raw milk. Positive cultures of TB were obtained in 40 of the 70 cases where TBLN tests were positive with fine needle aspiration cytology. Spoligotyping resulted in 31 different patterns, of which 25 isolates were Mycobacterium (M.) tuberculosis, and the remaining were M. africanum (4 isolates) and M. bovis (2 isolates). None of the animals showed positive test results for bovine TB by comparative intradermal tuberculin test. Based on the identification of M. bovis from two patients diagnosed with TBLN, we obtained preliminary evidence of zoonotic transmission of TB in northwestern Ethiopia. We did not identify a direct route of transmission between cattle and its owners. This is the objective of further investigations.

  16. Preliminary study of a hydrogen peroxide rocket for use in moving source jet noise tests

    NASA Technical Reports Server (NTRS)

    Plencner, R. M.

    1977-01-01

    A preliminary investigation was made of using a hydrogen peroxide rocket to obtain pure moving source jet noise data. The thermodynamic cycle of the rocket was analyzed. It was found that the thermodynamic exhaust properties of the rocket could be made to match those of typical advanced commercial supersonic transport engines. The rocket thruster was then considered in combination with a streamlined ground car for moving source jet noise experiments. When a nonthrottlable hydrogen peroxide rocket was used to accelerate the vehicle, propellant masses and/or acceleration distances became too large. However, when a throttlable rocket or an auxiliary system was used to accelerate the vehicle, reasonable propellant masses could be obtained.

  17. Preliminary Work for Identifying and Tracking Combustion Reaction Pathways by Coherent Microwave Mapping of Photoelectrons

    DTIC Science & Technology

    2016-06-24

    wall Radar technique has been built and preliminary results of pyrolysis of iso-butane have been obtained. Qualitative measurements of ethylene in...The (2+1) REMPI ionizations of ethylene (C2H4, 11B3u(π,3p) Rydberg manifold) was selectively induced at 310─325nm. The ethylene was detectable at...quantitative measurements of ethylene as one of the pyrolysis products by using coherent microwave Rayleigh scattering (Radar) from Resonant Enhanced Multi

  18. IRIS Toxicological Review of Inorganic Arsenic (Preliminary Assessment Materials)

    EPA Science Inventory

    In April 2014, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for inorganic arsenic (iAs) to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA ...

  19. Preliminary Iron Distribution on Vesta

    NASA Technical Reports Server (NTRS)

    Mittlefehldt, David W.; Mittlefehldt, David W.

    2013-01-01

    The distribution of iron on the surface of the asteroid Vesta was investigated using Dawn's Gamma Ray and Neutron Detector (GRaND) [1,2]. Iron varies predictably with rock type for the howardite, eucrite, and diogenite (HED) meteorites, thought to be representative of Vesta. The abundance of Fe in howardites ranges from about 12 to 15 wt.%. Basaltic eucrites have the highest abundance, whereas, lower crustal and upper mantle materials (cumulate eucrites and diogenites) have the lowest, and howardites are intermediate [3]. We have completed a mapping study of 7.6 MeV gamma rays produced by neutron capture by Fe as measured by the bismuth germanate (BGO) detector of GRaND [1]. The procedures to determine Fe counting rates are presented in detail here, along with a preliminary distribution map, constituting the necessary initial step to quantification of Fe abundances. We find that the global distribution of Fe counting rates is generally consistent with independent mineralogical and compositional inferences obtained by other instruments on Dawn such as measurements of pyroxene absorption bands by the Visual and Infrared Spectrometer (VIR) [4] and Framing Camera (FC) [5] and neutron absorption measurements by GRaND [6].

  20. The preliminary analysis of the reliability and validity of the Chinese Edition of the CSBS DP.

    PubMed

    Lin, Chu-Sui; Chang, Shu-Hui; Cheng, Shu-Fen; Chao, Pen-Chiang; Chiu, Chun-Hao

    2015-03-01

    This study marked a preliminary attempt to standardize the Chinese Edition of the Communication and Symbolic Behavior Scales Developmental Profile (Wetherby & Prizant, 2002; CSBS DP) to assist in the early identification of young children with special needs in Taiwan. The study was conducted among 171 infants and toddlers aged 1-2. It also included a follow-up study one year after the initial test. Three domestically developed standardized child development inventories were used to measure the concurrent validity and predictive validity. The Chinese Edition of the CSBS DP demonstrated overall good test-retest and inter-rater reliability. It also showed good concurrent and predictive validity. The current study yields preliminary evidence that the Chinese Edition of the CSBS DP could be a valuable assessment tool worthy of wider distribution. Future research should employ random sampling to establish a true national norm. Additionally, the follow-up study needs to include atypical groups and to expand to children aged 6-12 months to strengthen the applicability of the instrument in Taiwan. Copyright © 2014 Elsevier Ltd. All rights reserved.

  1. The relationship between self-control, job satisfaction and life satisfaction in Chinese employees: A preliminary study.

    PubMed

    Dou, Kai; Nie, Yan-Gang; Wang, Yu-Jie; Liu, Yao-Zhong

    2016-01-01

    Previous studies have demonstrated that self-control is positively related to life satisfaction, but this association in Chinese employees and its underlying mechanism are less commonly investigated. In this preliminary study the relationships between self-control and life satisfaction and the mediating effect of job satisfaction were tested. Participants were 482 full-time employees (188 male, 294 female) from different cities in China. They answered self-report questionnaires online that assessed self-control, job satisfaction, and life satisfaction. Path analyses were conducted and bootstrap technique was used to judge the significance of the mediation. Self-control was positively related to both job and life satisfaction. More importantly, job satisfaction significantly mediated the association between self-control and life satisfaction. Furthermore, there was no significant difference in the size of the mediating effect between intrinsic and extrinsic job satisfaction. Results of this preliminary study provide further evidence of the positive association between self-control and life satisfaction. Job satisfaction is found to mediate this relationship.

  2. Decreases in smoking during treatment for methamphetamine-use disorders: preliminary evidence.

    PubMed

    McPherson, Sterling; Orr, Michael; Lederhos, Crystal; McDonell, Michael; Leickly, Emily; Hirchak, Katherine; Oluwoye, Oladunni A; Murphy, Sean M; Layton, Matthew; Roll, John M

    2018-06-01

    Despite high rates of smoking (70-90%) and the severely negative impact of smoking on physical and mental health, only 12% of individuals receiving stimulant-use disorder treatment also receive smoking-cessation treatment. The aim of this investigation was to examine the effect of a contingency management (CM) intervention targeting methamphetamine (MA) use on cigarette smoking. Sixty-one adults with MA-use disorders who were smokers were assigned to CM or standard psychosocial treatment. Rates of smoking-negative breath samples (carbon monoxide <3 ppm) were compared between the two groups while controlling for baseline carbon monoxide level, marijuana use, MA use, and time. This subgroup of mostly male (59%) participants included 44 participants in the CM group and 17 participants in the standard psychosocial treatment. Tobacco smoking participants who received CM targeting MA use were 140% (odds ratio: 2.395; 95% confidence interval: 1.073-5.346) more likely to submit a smoking-negative breath sample relative to standard psychosocial treatment during the treatment period, holding constant several other prespecified covariates. This study provides evidence that a behavioral treatment for MA use results in reductions in cigarette smoking in adults with MA-use disorder.

  3. Properties of the Lunar Interior: Preliminary Results from the GRAIL Mission

    NASA Technical Reports Server (NTRS)

    Williams, James G.; Konopliv, Alexander S.; Asmar, Sami W.; Lemoine, Frank G.; Melosh, H. Jay; Neumann, Gregory A.; Phillips, Roger J.; Smith, David E.; Solomon, Sean C.; Watkins, Michael M.; hide

    2013-01-01

    The Gravity Recovery and Interior Laboratory (GRAIL) mission [1] has provided lunar gravity with unprecedented accuracy and resolution. GRAIL has produced a high-resolution map of the lunar gravity field [2,3] while also determining tidal response. We present the latest gravity field solution and its preliminary implications for the Moon's interior structure, exploring properties such as the mean density, moment of inertia of the solid Moon, and tidal potential Love number k(sub 2). Lunar structure includes a thin crust, a thick mantle layer, a fluid outer core, and a suspected solid inner core. An accurate Love number mainly improves knowledge of the fluid core and deep mantle. In the future, we will search for evidence of tidal dissipation and a solid inner core using GRAIL data.

  4. On the purification and preliminary crystallographic analysis of isoquinoline 1-oxidoreductase from Brevundimonas diminuta 7

    PubMed Central

    Boer, D. Roeland; Müller, Axel; Fetzner, Susanne; Lowe, David J.; Romão, Maria João

    2005-01-01

    Isoquinoline 1-oxidoreductase (IOR) from Brevundimonas diminuta is a mononuclear molybdoenzyme of the xanthine-dehydrogenase family of proteins and catalyzes the conversion of isoquinoline to isoquinoline-1-one. Its primary sequence and behaviour, specifically in its substrate specificity and lipophilicity, differ from other members of the family. A crystal structure of the enzyme is expected to provide an explanation for these differences. This paper describes the crystallization and preliminary X-ray diffraction experiments as well as an optimized purification protocol for IOR. Crystallization of IOR was achieved using two different crystallization buffers. Streak-seeding and cross-linking were essential to obtain well diffracting crystals. Suitable cryo-conditions were found and a structure solution was obtained by molecular replacement. However, phases need to be improved in order to obtain a more interpretable electron-density map. PMID:16508115

  5. Preliminary Evidence of "Other-Race Effect"-Like Behavior Induced by Cathodal-tDCS over the Right Occipital Cortex, in the Absence of Overall Effects on Face/Object Processing.

    PubMed

    Costantino, Andrea I; Titoni, Matilde; Bossi, Francesco; Premoli, Isabella; Nitsche, Michael A; Rivolta, Davide

    2017-01-01

    Neuromodulation techniques such as tDCS have provided important insight into the neurophysiological mechanisms that mediate cognition. Albeit anodal tDCS (a-tDCS) often enhances cognitive skills, the role of cathodal tDCS (c-tDCS) in visual cognition is largely unexplored and inconclusive. Here, in a single-blind, sham-controlled study, we investigated the offline effects of 1.5 mA c-tDCS over the right occipital cortex of 86 participants on four tasks assessing perception and memory of both faces and objects. Results demonstrated that c-tDCS does not overall affect performance on the four tasks. However, post-hoc exploratory analysis on participants' race (Caucasian vs. non-Caucasians), showed a "face-specific" performance decrease (≈10%) in non-Caucasian participants only . This preliminary evidence suggests that c-tDCS can induce "other-race effect (ORE)-like" behavior in non-Caucasian participants that did not show any ORE before stimulation (and in case of sham stimulation). Our results add relevant information about the breadth of cognitive processes and visual stimuli that can be modulated by c-tDCS, about the design of effective neuromodulation protocols, and have important implications for the potential neurophysiological bases of ORE.

  6. Obtaining resources for evidence-based public health initiatives at the local level: insights from the Central Sydney Tobacco Control Plan.

    PubMed

    Rissel, C; McMaugh, K; O'Connor, D; Balafas, A; Ward, J

    1999-02-01

    In response to inquiries regarding the processes of developing a Tobacco Control Plan (TCP) for the Central Sydney Area Health Service (which in 1997 allocated dedicated funding of $ 800,000 over 2 1/2 years to implement the plan), this article describes the strengths and weaknesses of the TCP and outlines the process which contributed to its funding. Consistent with national and state priorities, the TCP recommended strategies based on best available evidence in the four action areas: reducing sales of cigarettes to minors, marketing, passive smoking and smoking cessation. Funding of this amount for a single public health issue at a local level represents a unique achievement in the application of an evidence-based approach to population health. Key elements of our advocacy methods included the involvement of all key primary health care and clinical stakeholders; comprehensive background research to identify evidence-based strategies; careful attention to budget options; strategic lobbying of senior staff and decision makers; the proposal for a multidisciplinary management structure for the TCP and specifications for funding allocation and evaluation. Early achievements and other reflections are discussed.

  7. Preliminary Experiment of Non-Inductive Plasma Current Startup in SUNIST Spherical Tokamak

    NASA Astrophysics Data System (ADS)

    He, Yexi; Zhang, Liang; Xie, Lifeng; Tang, Yi; Yang, Xuanzong; Feng, Chunhua; Fu, Hongjun

    2006-01-01

    The non-inductive plasma current startup is an important motivation in SUNIST spherical tokamak. In the recent experiment, the magnetron microwave system of 100 kW and 2.45 GHz has been used to the ECR plasma current startup. Besides the toroidal field, a vertical field was applied to generate preliminary toroidal plasma current without the action of the central solenoid. As the evidence of plasma current startup with the effect of vertical field drift, the direction of plasma current is changed when the direction of vertical field changes during the ECR plasma current startup discharge. We also observed a maximum plasma current by scanning vertical field in both directions. Additionally, we used electrode discharge to assist the ECR plasma current startup.

  8. Fly's Eye GLM Simulator Preliminary Validation Analysis

    NASA Astrophysics Data System (ADS)

    Quick, M. G.; Christian, H. J., Jr.; Blakeslee, R. J.; Stewart, M. F.; Corredor, D.; Podgorny, S.

    2017-12-01

    As part of the validation effort for the Geostationary Lightning Mapper (GLM) an airborne radiometer array has been fabricated to observe lightning optical emission through the cloud top. The Fly's Eye GLM Simulator (FEGS) is a multi-spectral, photo-electric radiometer array with a nominal spatial resolution of 2 x 2 km and spatial footprint of 10 x 10 km at cloud top. A main 25 pixel array observes the 777.4 nm oxygen emission triplet using an optical passband filter with a 10 nm FWHM, a sampling rate of 100 kHz, and 16 bit resolution. From March to May of 2017 FEGS was flown on the NASA ER-2 high altitude aircraft during the GOES-R Validation Flight Campaign. Optical signatures of lightning were observed during a variety of thunderstorm scenarios while coincident measurements were obtained by GLM and ground based antennae networks. This presentation will describe the preliminary analysis of the FEGS dataset in the context of GLM validation.

  9. Preliminary Calibration Report of an Apparatus to Measure Vibration Characteristics of Low Frequency Disturbance Source Devices

    NASA Technical Reports Server (NTRS)

    Russell, James W.; Marshall, Robert A.; Finley, Tom D.; Lawrence, George F.

    1994-01-01

    This report presents a description of the test apparatus and the method of testing the low frequency disturbance source characteristics of small pumps, fans, camera motors, and recorders that are typical of those used in microgravity science facilities. The test apparatus will allow both force and acceleration spectra of these disturbance devices to be obtained from acceleration measurements over the frequency range from 2 to 300 Hz. Some preliminary calibration results are presented.

  10. Preliminary investigation into the analytical potential of a multiwavelength fiber drop analyzer with special reference to applications in medical diagnostics

    NASA Astrophysics Data System (ADS)

    McMillan, Norman D.; O'Mongain, Eon; Walsh, James E.; Breen, Liam; McMillan, Duncan G.; Power, Michael J.; O'Dea, John P.; Kinsella, Seamus M.; Kelly, Mairead P.; Hammil, Conor; Orr, Dermot

    1994-12-01

    A preliminary investigation into the use of multiwavelength fiber drop analyzer (FDA) for the measurement of viscosity, spectral absorbance and refractive index is made with a view to obtaining conservative estimates of the instrumental capability of the FDA for these measurands. Some important new insights into drop vibrations are made from studies on the fiber drop traces (FDTs) of mechanically excited damped vibrations in drops with a set volume. A brief description of the feasibility measurements on the first application of the FDA in the diagnosis of disease in synovial fluid is given. Strong experimental evidence is reported for the existence of the surface-guided wave peak of the fiber drop trace and some new insights into the nature of the FDT are suggested based on a comparative study of the FDTs from a multiple-wavelength and a single-wavelength FDA. The earlier reported drop period dependence on applied electric field is critically reexamined, a new interpretation of this effect, is suggested, and an experimental study of clarification is given. Finally, a brief review of the projected capabilities of the FDA based on the work reported here is provided.

  11. Preliminary AirMSPI Datasets

    Atmospheric Science Data Center

    2018-02-26

    ... Datasets   The data files available through this web page and ftp links are preliminary AIrMSPI datasets from recent campaigns. ... and geometric corrections. Caution should be used for science analysis. At a later date, more qualified versions will be made public. ...

  12. IRIS Toxicological Review of Hexabromocyclododecane (HBCD) (Preliminary Assessment Materials)

    EPA Science Inventory

    In March 2014, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for HBCD to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in c...

  13. Preliminary design package for Sunair SEC-601 solar collector

    NASA Technical Reports Server (NTRS)

    1978-01-01

    The preliminary design of the Owens-Illinois model Sunair SEC-601 tubular air solar collector is presented. Information in this package includes the subsystem design and development approaches, hazard analysis, and detailed drawings available as the preliminary design review.

  14. Preliminary determination of Newtonian gravitational constant with angular acceleration feedback method.

    PubMed

    Xue, Chao; Quan, Li-Di; Yang, Shan-Qing; Wang, Bing-Peng; Wu, Jun-Fei; Shao, Cheng-Gang; Tu, Liang-Cheng; Milyukov, Vadim; Luo, Jun

    2014-10-13

    This paper describes the preliminary measurement of the Newtonian gravitational constant G with the angular acceleration feedback method at HUST. The apparatus has been built, and preliminary measurement performed, to test all aspects of the experimental design, particularly the feedback function, which was recently discussed in detail by Quan et al. The experimental results show that the residual twist angle of the torsion pendulum at the signal frequency introduces 0.4 ppm to the value of G. The relative uncertainty of the angular acceleration of the turntable is approximately 100 ppm, which is mainly limited by the stability of the apparatus. Therefore, the experiment has been modified with three features: (i) the height of the apparatus is reduced almost by half, (ii) the aluminium shelves were replaced with shelves made from ultra-low expansion material and (iii) a perfect compensation of the laboratory-fixed gravitational background will be carried out. With these improvements, the angular acceleration is expected to be determined with an uncertainty of better than 10 ppm, and a reliable value of G with 20 ppm or below will be obtained in the near future. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

  15. Preliminary assessment on the bioaccessibility of contaminants of emerging concern in raw and cooked seafood.

    PubMed

    Alves, Ricardo N; Maulvault, Ana L; Barbosa, Vera L; Cunha, Sara; Kwadijk, Christiaan J A F; Álvarez-Muñoz, Diana; Rodríguez-Mozaz, Sara; Aznar-Alemany, Òscar; Eljarrat, Ethel; Barceló, Damià; Fernandez-Tejedor, Margarita; Tediosi, Alice; Marques, António

    2017-06-01

    A preliminary assessment of the bioaccessibility of contaminants of emerging concern (CeCs), including perfluorinated compounds (PFCs; i.e. PFOS and PFUnA), brominated flame retardants (BFRs; i.e. BDE47, BDE100, α-HBCD) and pharmaceuticals and personal care products (PPCPs; i.e. venlafaxine, methylparaben and UV-filter OC) was performed in seafood species available in the European markets. Additionally, the effect of steaming on CeCs bioaccessibility was also investigated for the first time. Overall, steaming affected differentially contaminants' concentrations, for instance, decreasing PFOS levels in flounder, but increasing both BDE47 and BDE100. CeCs bioaccessibility varied according to seafood species and contaminant group, i.e. in general, lower bioaccessibility values were obtained for PBDEs (<70%, except for mackerel), while PFCs and PPCPs revealed higher bioaccessibility percentages (between 71 and 95%). The lowest bioaccessibility value was obtained for α-HBCD (mussel; 14%), whereas the highest percentage was observed in venlafaxine (mullet; 95%). Our preliminary study reports also, for the first time, the effects of steaming on CeCs bioaccessibility. In most cases, bioaccessibility was not affected by cooking, however, a decrease was observed in PBDEs and venlafaxine bioaccessibility in steamed mussels and mullet, respectively, thus lowering the potential health risks associated with seafood consumption. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. The Soviet Military Views Operation Desert Storm: A Preliminary Assessment

    DTIC Science & Technology

    1991-09-23

    NO. IACCESSION NO. 11. TITLE (Include Security Classification) The Soviet Military Views Operation Desert Storm: .A Preliminary Assessment UNCLASSIFIED...VIEWS OPERATION DESERT STORM: A PRELIMINARY ASSESSMENT Stephen J. Blank Av~qoxa 10 a r I~ )~ I.RA&I .1 . a .. _ . . .. J l tia.o.. .. ._ ’Vflstribitleu...preliminary assessments , largely through the spring of 1991, suggest lines of argument that will surely appear later in greater depth, detail, and

  17. Adapting Evidence-Based Mental Health Treatments in Community Settings: Preliminary Results from a Partnership Approach

    ERIC Educational Resources Information Center

    Southam-Gerow, Michael A.; Hourigan, Shannon E.; Allin, Robert B., Jr.

    2009-01-01

    This article describes the application of a university-community partnership model to the problem of adapting evidence-based treatment approaches in a community mental health setting. Background on partnership research is presented, with consideration of methodological and practical issues related to this kind of research. Then, a rationale for…

  18. 46 CFR 67.101 - Waiver of evidence of build.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Waiver of evidence of build. 67.101 Section 67.101... DOCUMENTATION OF VESSELS Build Requirements for Vessel Documentation § 67.101 Waiver of evidence of build. (a) A vessel owner applying for documentation unable to obtain the evidence of build required by § 67.99 may...

  19. Subjective Fatigue in Children With Hearing Loss: Some Preliminary Findings

    PubMed Central

    Hornsby, Benjamin W. Y.; Werfel, Krystal; Camarata, Stephen; Bess, Fred H.

    2014-01-01

    Purpose In this study, the authors examined the effect of hearing loss on subjective reports of fatigue in school-age children using a standardized measure. Methods As part of a larger ongoing study, the authors obtained subjective ratings of fatigue using the Pediatric Quality of Life Inventory (PedsQL) Multidimensional Fatigue Scale (Varni, Burwinkle, Katz, Meeske, & Dickinson, 2002). This standardized scale provides a measure of general fatigue, sleep/rest fatigue, cognitive fatigue, and an overall composite measure of fatigue. To date, data from 10 children with hearing loss (CHL) and 10 age-matched children with normal hearing (CNH) have been analyzed. Results These preliminary results show that subjective fatigue is increased in school-age children with hearing loss (Cohen's d = 0.78–1.90). In addition, the impact of hearing loss on fatigue in school-age children appears pervasive across multiple domains (general, sleep/rest, and cognitive fatigue). Conclusion School-age CHL reported significantly more fatigue than did CNH. These preliminary data are important given the negative academic and psychosocial consequences associated with fatigue. Further research is needed to determine the underlying mechanisms responsible for this increased fatigue in school-age children with hearing loss, and to identify factors that may modulate (e.g., degree of loss) and mediate (e.g., hearing aid or cochlear implant use) its impact. PMID:23824428

  20. Preliminary design study for an atomospheric science facility

    NASA Technical Reports Server (NTRS)

    Hutchison, R.

    1972-01-01

    The activities and results of the Atmospheric Science Facility preliminary design study are reported. The objectives of the study were to define the scientific goals, to determine the range of experiment types, and to develop the preliminary instrument design requirements for a reusable, general purpose, optical research facility for investigating the earth's atmosphere from a space shuttle orbital vehicle.

  1. Preliminary Advanced Colloids Experiment

    NASA Image and Video Library

    2011-09-29

    ISS029-E-011867 (29 Sept. 2011) --- NASA astronaut Mike Fossum, Expedition 29 commander, works with the Light Microscopy Module (LMM) control box in the Destiny laboratory of the International Space Station in preparation for another session with the Preliminary Advanced Colloids Experiment (PACE) hardware.

  2. Scapulothoracic bursitis and snapping scapula syndrome: a critical review of current evidence.

    PubMed

    Warth, Ryan J; Spiegl, Ulrich J; Millett, Peter J

    2015-01-01

    Symptomatic scapulothoracic disorders, such as painful scapular crepitus and/or bursitis, are uncommon; however, they can produce significant pain and disability in many patients. To review the current knowledge pertaining to snapping scapula syndrome and to identify areas of further research that may be helpful to improve clinical outcomes and patient satisfaction. Systematic review. We performed a preliminary search of the PubMed and Embase databases using the search terms "snapping scapula," "scapulothoracic bursitis," "partial scapulectomy," and "superomedial angle resection" in September 2013. All nonreview articles related to the topic of snapping scapula syndrome were included. The search identified a total of 167 unique articles, 81 of which were relevant to the topic of snapping scapula syndrome. There were 36 case series of fewer than 10 patients, 16 technique papers, 11 imaging studies, 9 anatomic studies, and 9 level IV outcomes studies. The level of evidence obtained from this literature search was inadequate to perform a formal systematic review or meta-analysis. Therefore, a critical review of current evidence is presented. Snapping scapula syndrome, a likely underdiagnosed condition, can produce significant shoulder dysfunction in many patients. Because the precise origin is typically unknown, specific treatments that are effective for some patients may not be effective for others. Nevertheless, bursectomy with or without partial scapulectomy is currently the most effective primary method of treatment in patients who fail nonoperative therapy. However, many patients experience continued shoulder disability even after surgical intervention. Future studies should focus on identifying the modifiable factors associated with poor outcomes after operative and nonoperative management for snapping scapula syndrome in an effort to improve clinical outcomes and patient satisfaction. © 2014 The Author(s).

  3. Preliminary analysis of in utero low-level arsenic exposure and fetal growth using biometric measurements extracted from fetal ultrasound reports.

    PubMed

    Davis, Matthew A; Higgins, John; Li, Zhigang; Gilbert-Diamond, Diane; Baker, Emily R; Das, Amar; Karagas, Margaret R

    2015-03-30

    Early life exposure to arsenic is associated with decreased birth weight in highly exposed populations but little is known about effects of low-level arsenic exposure on growth in utero. Using a sample of 272 pregnancies from New Hampshire we obtained biometric measurements directly from fetal ultrasound reports commonly found in electronic medical records. We used information extraction methods to develop and validate an automated approach for mining biometric measurements from the text of clinical reports. As a preliminary analysis, we examined associations between in utero low-level arsenic exposure (as measured by maternal urinary arsenic concentration) and fetal growth measures (converted to Z-scores based on reference populations for estimated fetal weight, head, and other body measures) at approximately 18 weeks of gestation. In a preliminary cross-sectional analysis of 223 out of 272 pregnancies, maternal urinary arsenic concentration (excluding arsenobetaine) was associated with a reduction in head circumference Z-score (Spearman correlation coefficient, rs = -0.08, p-value = 0.21) and a stronger association was observed among female fetuses at approximately 18 weeks of gestation (rs = - 0.21, p-value < 0.05). Although, associations were attenuated in adjusted analyses - among female fetuses a 1 μg/L increase in maternal urinary arsenic concentration was associated with a decrease of 0.047 (95% CI: -0.115, 0.021) in head circumference and 0.072 (95% CI: -0.151, 0.007) decrease in biparietal head diameter Z-score. Our study demonstrates that useful data can be extracted directly from electronic medical records for epidemiologic research. We also found evidence that exposure to low-level arsenic may be associated with reduced head circumference in a sex dependent manner that warrants further investigation.

  4. Optical spectra obtained from amorphous films of rubrene: Evidence for predominance of twisted isomer

    NASA Astrophysics Data System (ADS)

    Kytka, M.; Gisslen, L.; Gerlach, A.; Heinemeyer, U.; Kováč, J.; Scholz, R.; Schreiber, F.

    2009-06-01

    In order to investigate the optical properties of rubrene we study the vibronic progression of the first absorption band (lowest π →π∗ transition). We analyze the dielectric function ɛ2 of rubrene in solution and thin films using the displaced harmonic oscillator model and derive all relevant parameters of the vibronic progression. The findings are supplemented by density functional calculations using B3LYP hybrid functionals. Our theoretical results for the molecule in two different conformations, i.e., with a twisted or planar tetracene backbone, are in very good agreement with the experimental data obtained for rubrene in solution and thin films. Moreover, a simulation based on the monomer spectrum and the calculated transition energies of the two conformations indicates that the thin film spectrum of rubrene is dominated by the twisted isomer.

  5. Optical spectra obtained from amorphous films of rubrene: Evidence for predominance of twisted isomer.

    PubMed

    Kytka, M; Gisslen, L; Gerlach, A; Heinemeyer, U; Kovác, J; Scholz, R; Schreiber, F

    2009-06-07

    In order to investigate the optical properties of rubrene we study the vibronic progression of the first absorption band (lowest pi-->pi( *) transition). We analyze the dielectric function epsilon(2) of rubrene in solution and thin films using the displaced harmonic oscillator model and derive all relevant parameters of the vibronic progression. The findings are supplemented by density functional calculations using B3LYP hybrid functionals. Our theoretical results for the molecule in two different conformations, i.e., with a twisted or planar tetracene backbone, are in very good agreement with the experimental data obtained for rubrene in solution and thin films. Moreover, a simulation based on the monomer spectrum and the calculated transition energies of the two conformations indicates that the thin film spectrum of rubrene is dominated by the twisted isomer.

  6. Energy and raw material potentials of wood residue in the Pacific Coast States: a summary of a preliminary feasibility investigation.

    Treesearch

    John B. Grantham; Eldon Estep; John M. Pierovich; Harold Tarkow; Thomas C. Adams

    1974-01-01

    Results are reported of a preliminary investigation of feasibility of using wood residue to meet energy and raw material needs in the Pacific Coast States. Magnitude of needs was examined and volume of logging-residue and unused mill residue was estimated. Costs of obtaining and preprocessing logging residue for energy and pulp and particle board raw material were...

  7. Preliminary results from the Arecibo Heating Experiment (HEX): HF to GNSS

    NASA Astrophysics Data System (ADS)

    Jackson-Booth, N.; Penney, R.; Bernhardt, P. A.; Martin, P. L.; Buckland, R.; Morton-Orr, T.; Nossa, E.; Buckland, R.

    2017-12-01

    The ionosphere is subject to many solar and terrestrial influences that can generate disturbances, causing degradation to modern communication and navigational systems. Whilst the disturbances are normally caused by natural phenomena such as hurricanes, earthquakes and solar storms; they can also be generated by artificially modifying the ionosphere. Artificial Ionospheric Modification (AIM) attempts to alter a small region of the ionosphere in order to perturb the RF propagation environment. This can be achieved through injecting the ionosphere with aerosols, chemicals or radio signals. The effects of any such modification can be detected through the deployment of sensors, including ground based high-frequency (HF) sounders and dual-band Global Navigation Satellite System (GNSS) receivers. HF sounders allow measurements of the bottom-side of the ionosphere. GNSS receivers offer a convenient means of obtaining information about the ionosphere, including ionospheric disturbances through changes in the derived total electron content information. The Heating EXperiment (HEX), which took place in March and May 2017, was designed to further our understanding of the phenomena caused by artificially heating a small region of the ionosphere, using the Arecibo facility in Puerto Rico. This was achieved by utilizing a HF measurement experiment spread between Texas and Trinidad and the deployment of a small scale travelling ionospheric disturbance (TID) network near the heater. The TID network comprised three GNSS receivers along baselines of approximately 4 km, located 20 km north of the heater. This paper presents preliminary results from the HEX campaign, including evidence of heating-induced disturbances enhancing propagation between Virginia and Trinidad. The implications of generated irregularities on GNSS will also be discussed.

  8. 28 CFR 36.605 - Procedure following preliminary determination of equivalency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... State Laws or Local Building Codes § 36.605 Procedure following preliminary determination of equivalency... of the preliminary determination of equivalency with respect to the particular code, and invite...

  9. Developing and Evaluating Communication Strategies to Support Informed Decisions and Practice Based on Evidence (DECIDE): protocol and preliminary results.

    PubMed

    Treweek, Shaun; Oxman, Andrew D; Alderson, Philip; Bossuyt, Patrick M; Brandt, Linn; Brożek, Jan; Davoli, Marina; Flottorp, Signe; Harbour, Robin; Hill, Suzanne; Liberati, Alessandro; Liira, Helena; Schünemann, Holger J; Rosenbaum, Sarah; Thornton, Judith; Vandvik, Per Olav; Alonso-Coello, Pablo

    2013-01-09

    Healthcare decision makers face challenges when using guidelines, including understanding the quality of the evidence or the values and preferences upon which recommendations are made, which are often not clear. GRADE is a systematic approach towards assessing the quality of evidence and the strength of recommendations in healthcare. GRADE also gives advice on how to go from evidence to decisions. It has been developed to address the weaknesses of other grading systems and is now widely used internationally. The Developing and Evaluating Communication Strategies to Support Informed Decisions and Practice Based on Evidence (DECIDE) consortium (http://www.decide-collaboration.eu/), which includes members of the GRADE Working Group and other partners, will explore methods to ensure effective communication of evidence-based recommendations targeted at key stakeholders: healthcare professionals, policymakers, and managers, as well as patients and the general public. Surveys and interviews with guideline producers and other stakeholders will explore how presentation of the evidence could be improved to better meet their information needs. We will collect further stakeholder input from advisory groups, via consultations and user testing; this will be done across a wide range of healthcare systems in Europe, North America, and other countries. Targeted communication strategies will be developed, evaluated in randomized trials, refined, and assessed during the development of real guidelines. Results of the DECIDE project will improve the communication of evidence-based healthcare recommendations. Building on the work of the GRADE Working Group, DECIDE will develop and evaluate methods that address communication needs of guideline users. The project will produce strategies for communicating recommendations that have been rigorously evaluated in diverse settings, and it will support the transfer of research into practice in healthcare systems globally.

  10. Developing an evidence-based practice protocol: implications for midwifery practice.

    PubMed

    Carr, K C

    2000-01-01

    Evidence-based practice is defined and its importance to midwifery practice is presented. Guidelines are provided for the development of an evidence-based practice protocol. These include: identifying the clinical question, obtaining the evidence, evaluating the validity and importance of the evidence, synthesizing the evidence and applying it to the development of a protocol or clinical algorithm, and, finally, developing an evaluation plan or measurement strategy to see if the new protocol is effective.

  11. Development and preliminary evidence for the validity of an instrument assessing implementation of human-factors principles in medication-related decision-support systems—I-MeDeSA

    PubMed Central

    Zachariah, Marianne; Seidling, Hanna M; Neri, Pamela M; Cresswell, Kathrin M; Duke, Jon; Bloomrosen, Meryl; Volk, Lynn A; Bates, David W

    2011-01-01

    Background Medication-related decision support can reduce the frequency of preventable adverse drug events. However, the design of current medication alerts often results in alert fatigue and high over-ride rates, thus reducing any potential benefits. Methods The authors previously reviewed human-factors principles for relevance to medication-related decision support alerts. In this study, instrument items were developed for assessing the appropriate implementation of these human-factors principles in drug–drug interaction (DDI) alerts. User feedback regarding nine electronic medical records was considered during the development process. Content validity, construct validity through correlation analysis, and inter-rater reliability were assessed. Results The final version of the instrument included 26 items associated with nine human-factors principles. Content validation on three systems resulted in the addition of one principle (Corrective Actions) to the instrument and the elimination of eight items. Additionally, the wording of eight items was altered. Correlation analysis suggests a direct relationship between system age and performance of DDI alerts (p=0.0016). Inter-rater reliability indicated substantial agreement between raters (κ=0.764). Conclusion The authors developed and gathered preliminary evidence for the validity of an instrument that measures the appropriate use of human-factors principles in the design and display of DDI alerts. Designers of DDI alerts may use the instrument to improve usability and increase user acceptance of medication alerts, and organizations selecting an electronic medical record may find the instrument helpful in meeting their clinicians' usability needs. PMID:21946241

  12. The Thirty Gigahertz Instrument Receiver for the QUIJOTE Experiment: Preliminary Polarization Measurements and Systematic-Error Analysis

    PubMed Central

    Casas, Francisco J.; Ortiz, David; Villa, Enrique; Cano, Juan L.; Cagigas, Jaime; Pérez, Ana R.; Aja, Beatriz; Terán, J. Vicente; de la Fuente, Luisa; Artal, Eduardo; Hoyland, Roger; Génova-Santos, Ricardo

    2015-01-01

    This paper presents preliminary polarization measurements and systematic-error characterization of the Thirty Gigahertz Instrument receiver developed for the QUIJOTE experiment. The instrument has been designed to measure the polarization of Cosmic Microwave Background radiation from the sky, obtaining the Q, U, and I Stokes parameters of the incoming signal simultaneously. Two kinds of linearly polarized input signals have been used as excitations in the polarimeter measurement tests in the laboratory; these show consistent results in terms of the Stokes parameters obtained. A measurement-based systematic-error characterization technique has been used in order to determine the possible sources of instrumental errors and to assist in the polarimeter calibration process. PMID:26251906

  13. Metacognitions in desire thinking: a preliminary investigation.

    PubMed

    Caselli, Gabriele; Spada, Marcantonio M

    2010-10-01

    Desire thinking is defined as a voluntary thinking process orienting to prefigure images, information and memories about positive target-related experience. Recent research has highlighted the role of desire thinking in the maintenance of addictive, eating and impulse control disorders. Currently little is known about metacognitions in desire thinking. To investigate: (1) the presence and content of desire thinking during a desire experience; (2) the presence of metacognitive beliefs in desire thinking; (3) the goal of desire thinking; (4) attentional focus during desire thinking; and (5) the impact of desire thinking on craving. Twenty-four individuals with a diagnosis of either alcohol abuse, bulimia nervosa, pathological gambling or smoking dependence were assessed using a semi-structured interview. Findings indicated that participants engaged in desire thinking and endorsed both positive and negative metacognitive beliefs about this process. The goal of desire thinking was to regulate internal states. Participants also reported that during a desire experience their attentional focus was continuously shifting between internal state and external context and that engaging in desire thinking increased craving. These findings provide preliminary evidence that metacognitions play a role in desire thinking.

  14. Preliminary data for northern Great Plains test well 1, quarter NE quarter Sec. 11, T.55N., R.77W., Sheridan County, Wyoming

    USGS Publications Warehouse

    Lobmeyer, D.H.; Anna, L.O.; Busby, J.F.

    1982-01-01

    This report documents the preliminary data obtained from Northern Great Plains test well 1 and describes the preliminary results and future testing plans. The intended audience includes hydrologists, local water users, drilling contractors, and water managers. The test well was drilled as part of the study to determine the water resource potential of the regional aquifer system in the Northern Great Plains, an area of about 250,000 sq mi. The well is 4,485 ft deep; nine cores were drilled totaling 182 ft; 157.42 ft of core were recovered. Sidewall cores were obtained from 24 horizons. Gamma and density scans of the cores were made, and selected parts were tested for density, porosity, and vertical and horizontal permeability. Eight zones were perforated and tested using conventional drill-stem tests and swabbing. Water samples were obtained from seven zones. No major potential sources of groundwater were penetrated by the test well. Estimated yields from selected zones range from about 240 gal/min with 400 ft of drawdown to about 5 gal/min flow at the surface. Dissolved-solids concentrations ranged from about 1,800 to 3,000 mg/l. (USGS)

  15. Preliminary Survey of Icing Conditions Measured During Routine Transcontinental Airline Operation

    NASA Technical Reports Server (NTRS)

    Perkins, Porter J.

    1952-01-01

    Icing data collected on routine operations by four DC-4-type aircraft equipped with NACA pressure-type icing-rate meters are presented as preliminary information obtained from a statistical icing data program sponsored by the NACA with the cooperation of many airline companies and the United States Air Force. The program is continuing on a much greater scale to provide large quantities of data from many air routes in the United States and overseas. Areas not covered by established air routes are also being included in the survey. The four aircraft which collected the data presented in this report were operated by United Air Lines over a transcontinental route from January through May, 1951. An analysis of the pressure-type icing-rate meter was satisfactory for collecting statistical data during routine operations. Data obtained on routine flight icing encounters from.these four instrumented aircraft, although insufficient for a conclusive statistical analysis, provide a greater quantity and considerably more realistic information than that obtained from random research flights. A summary of statistical data will be published when the information obtained daring the 1951-52 icing season and that to be obtained during the 1952-53 season can be analyzed and assembled. The 1951-52 data already analyzed indicate that the quantity, quality, and range of icing information being provided by this expanded program should afford a sound basis for ice-protection-system design by defining the important meteorological parameters of the icing cloud.

  16. Feasibility, safety and preliminary evidence of the effectiveness of a home-based exercise programme for older people with Alzheimer's disease: a pilot randomized controlled trial.

    PubMed

    Suttanon, Plaiwan; Hill, Keith D; Said, Catherine M; Williams, Susan B; Byrne, Karin N; LoGiudice, Dina; Lautenschlager, Nicola T; Dodd, Karen J

    2013-05-01

    To evaluate the feasibility and safety of a home-based exercise programme for people with Alzheimer's disease, and to provide preliminary evidence of programme effectiveness in improving balance and mobility and reducing falls risk. A randomized controlled trial. Community. Forty people with mild to moderate Alzheimer's disease (mean age 81.9, SD 5.72; 62.5% female). Participants were randomized to a six-month home-based individually tailored balance, strengthening and walking exercise programme (physiotherapist) or a six-month home-based education programme (control) (occupational therapist). Both programmes provided six home-visits and five follow-up phone calls. Balance, mobility, falls and falls risk were measured at baseline and programme completion. Intention-to-treat analysis using a generalized linear model with group allocation as a predictor variable was performed to evaluate programme effectiveness. Feasibility and adverse events were systematically recorded at each contact. Fifty-eight per cent of the exercise group finished the programme, completing an average of 83% of prescribed sessions, with no adverse events reported. Functional Reach improved significantly (P = 0.002) in the exercise group (mean (SD), 2.28 (4.36)) compared to the control group (-2.99 (4.87)). Significant improvement was also observed for the Falls Risk for Older People - Community score (P = 0.008) and trends for improvement on several other balance, mobility, falls and falls risk measures for the exercise group compared to the control group. The exercise programme was feasible and safe and may help improve balance and mobility performance and reduce falls risk in people with Alzheimer's disease.

  17. 9.4T Human MRI: Preliminary Results

    PubMed Central

    Vaughan, Thomas; DelaBarre, Lance; Snyder, Carl; Tian, Jinfeng; Akgun, Can; Shrivastava, Devashish; Liu, Wanzahn; Olson, Chris; Adriany, Gregor; Strupp, John; Andersen, Peter; Gopinath, Anand; van de Moortele, Pierre-Francois; Garwood, Michael; Ugurbil, Kamil

    2014-01-01

    This work reports the preliminary results of the first human images at the new high-field benchmark of 9.4T. A 65-cm-diameter bore magnet was used together with an asymmetric 40-cm-diameter head gradient and shim set. A multichannel transmission line (transverse electromagnetic (TEM)) head coil was driven by a programmable parallel transceiver to control the relative phase and magnitude of each channel independently. These new RF field control methods facilitated compensation for RF artifacts attributed to destructive interference patterns, in order to achieve homogeneous 9.4T head images or localize anatomic targets. Prior to FDA investigational device exemptions (IDEs) and internal review board (IRB)-approved human studies, preliminary RF safety studies were performed on porcine models. These data are reported together with exit interview results from the first 44 human volunteers. Although several points for improvement are discussed, the preliminary results demonstrate the feasibility of safe and successful human imaging at 9.4T. PMID:17075852

  18. Corporate Health and Wellness and the Financial Bottom Line: Evidence From South Africa.

    PubMed

    Conradie, Christina Susanna; van der Merwe Smit, Eon; Malan, Daniel Pieter

    2016-02-01

    The research objective was to test the hypothesis that corporate health and wellness contributed positively to South African companies' financial results. The past share market performance of eligible healthy companies, based on Discovery's Healthy Company Index, was tracked under three investment scenarios and compared with the market performance on the basis of the JSE FTSE All Share Index. The evidence supports the hypothesis that a culture of health and wellness provides a financial advantage, in so far as the portfolio of healthy companies consistently outperformed the market over the selected simulations. Given the limitations of the investigation, namely small sample size, the brevity of the period of investigation, and the reliance on accessibility sampling, the research provides the first and preliminary evidence supportive of the direct financial benefits of companies' wellness programs.

  19. Reorganization of equivalence classes: effects of preliminary training and meaningful stimuli.

    PubMed

    Arntzen, Erik; Nartey, Richard K; Fields, Lanny

    2018-05-01

    In Condition 1, adults learned the baseline relations for the three equivalence classes A1-B1-C1-D1-E1, A2-B2-C2-D2-E2, and A3-B3-C3-D3-E3. Classes contained abstract shapes in the ABS and four preliminary training groups. Each class in the PIC group contained one picture and four abstract shapes. Before class formation for four other groups, preliminary training involved establishing identity (CC) or arbitrary (CX) relations either with or without a delay. Without preliminary training, classes formed with low and high likelihoods in the ABS and PIC groups, respectively. Preliminary training with no delay produced modest increases in class formation, while preliminary training with delay produced large increases in class formation. Condition 2 replicated Condition 1 but with training of reassigned BC and CD relations that linked C from one class to B and D from another class: B1-C2, B2-C3, B3-C1, C2-D1, C3-D2, and C1-D3. Subsequent tests assessed the emergence of the reorganized classes A1-B1-C2-D1-E1, A2-B2-C3-D2-E2, and A3-B3-C1-D3-E3. All preliminary training procedures increased likelihood of forming the reorganized classes to the level seen in the PIC group. Greater gains were produced by preliminary training with no delays than with delays. Test performances also showed how preliminary training influenced baseline acquisition speed and participant-defined relations. © 2018 Society for the Experimental Analysis of Behavior.

  20. Preliminary study of a millimeter wave FMCW InSAR for UAS indoor navigation.

    PubMed

    Scannapieco, Antonio F; Renga, Alfredo; Moccia, Antonio

    2015-01-22

    Small autonomous unmanned aerial systems (UAS) could be used for indoor inspection in emergency missions, such as damage assessment or the search for survivors in dangerous environments, e.g., power plants, underground railways, mines and industrial warehouses. Two basic functions are required to carry out these tasks, that is autonomous GPS-denied navigation with obstacle detection and high-resolution 3Dmapping with moving target detection. State-of-the-art sensors for UAS are very sensitive to environmental conditions and often fail in the case of poor visibility caused by dust, fog, smoke, flames or other factors that are met as nominal mission scenarios when operating indoors. This paper is a preliminary study concerning an innovative radar sensor based on the interferometric Synthetic Aperture Radar (SAR) principle, which has the potential to satisfy stringent requirements set by indoor autonomous operation. An architectural solution based on a frequency-modulated continuous wave (FMCW) scheme is proposed after a detailed analysis of existing compact and lightweight SAR. A preliminary system design is obtained, and the main imaging peculiarities of the novel sensor are discussed, demonstrating that high-resolution, high-quality observation of an assigned control volume can be achieved.

  1. Preliminary Study of a Millimeter Wave FMCW InSAR for UAS Indoor Navigation

    PubMed Central

    Scannapieco, Antonio F.; Renga, Alfredo; Moccia, Antonio

    2015-01-01

    Small autonomous unmanned aerial systems (UAS) could be used for indoor inspection in emergency missions, such as damage assessment or the search for survivors in dangerous environments, e.g., power plants, underground railways, mines and industrial warehouses. Two basic functions are required to carry out these tasks, that is autonomous GPS-denied navigation with obstacle detection and high-resolution 3D mapping with moving target detection. State-of-the-art sensors for UAS are very sensitive to environmental conditions and often fail in the case of poor visibility caused by dust, fog, smoke, flames or other factors that are met as nominal mission scenarios when operating indoors. This paper is a preliminary study concerning an innovative radar sensor based on the interferometric Synthetic Aperture Radar (SAR) principle, which has the potential to satisfy stringent requirements set by indoor autonomous operation. An architectural solution based on a frequency-modulated continuous wave (FMCW) scheme is proposed after a detailed analysis of existing compact and lightweight SAR. A preliminary system design is obtained, and the main imaging peculiarities of the novel sensor are discussed, demonstrating that high-resolution, high-quality observation of an assigned control volume can be achieved. PMID:25621606

  2. Cell emulation and preliminary results.

    DOT National Transportation Integrated Search

    2016-07-01

    This report details preliminary results of the testing plan implemented by the Hawaii Natural Energy Institute to evaluate Electric Vehicle (EV) battery durability and reliability under electric utility grid operations. Commercial EV battery cells ar...

  3. Violent and Nonviolent Youth Offenders: Preliminary Evidence on Group Subtypes.

    PubMed

    Lai, Violet; Zeng, Gerald; Chu, Chi Meng

    2016-07-01

    Youth violence is a costly social problem. This study compared the risk and needs of nonviolent youth offenders, with those who had committed violent offenses only (violent only) and those who had committed violent and nonviolent offenses (violent plus) to determine whether violent youth were a different "type" from nonviolent youth. The case files of 3,744 youth offenders (3,327 males and 417 females, between 12 and 18 years old) were retrospectively coded, before official recidivism records were obtained. Multivariate analysis of variance (MANOVA), χ 2 , and Cox regressions were conducted. Violent-plus youth were younger; higher in their total risk and all criminogenic needs; more likely to have several noncriminogenic needs; and at higher risk of any reoffending, violent reoffending, and nonviolent reoffending than nonviolent youth. Violent-only youth had the same total risk and risk of general and violent recidivism as nonviolent offenders but presented different criminogenic and noncriminogenic needs and risk of nonviolent recidivism. Compared to violent-only youth, violent-plus youth were younger, had higher total risk and criminogenic needs on five domains, were more likely to have several noncriminogenic needs, and were at higher risk of all types of reoffending (except sexual reoffending), suggesting subtypes of violent youth offenders. The implication is that nonviolent and violent youth offenders require different dosage and types of intervention.

  4. 20 CFR 219.21 - Types of evidence to prove age.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) Preferred evidence. The best type of evidence to prove a claimant's age is— (1) A birth certificate recorded before age 5; (2) A church record of birth or baptism recorded before age 5; or (3) Notification of registration of birth made before age 5. (b) Other evidence of age. If an individual cannot obtain preferred...

  5. 20 CFR 219.21 - Types of evidence to prove age.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) Preferred evidence. The best type of evidence to prove a claimant's age is— (1) A birth certificate recorded before age 5; (2) A church record of birth or baptism recorded before age 5; or (3) Notification of registration of birth made before age 5. (b) Other evidence of age. If an individual cannot obtain preferred...

  6. 20 CFR 219.21 - Types of evidence to prove age.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) Preferred evidence. The best type of evidence to prove a claimant's age is— (1) A birth certificate recorded before age 5; (2) A church record of birth or baptism recorded before age 5; or (3) Notification of registration of birth made before age 5. (b) Other evidence of age. If an individual cannot obtain preferred...

  7. 20 CFR 219.21 - Types of evidence to prove age.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) Preferred evidence. The best type of evidence to prove a claimant's age is— (1) A birth certificate recorded before age 5; (2) A church record of birth or baptism recorded before age 5; or (3) Notification of registration of birth made before age 5. (b) Other evidence of age. If an individual cannot obtain preferred...

  8. 20 CFR 219.21 - Types of evidence to prove age.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Preferred evidence. The best type of evidence to prove a claimant's age is— (1) A birth certificate recorded before age 5; (2) A church record of birth or baptism recorded before age 5; or (3) Notification of registration of birth made before age 5. (b) Other evidence of age. If an individual cannot obtain preferred...

  9. Preliminary evidence of altered neural response during intertemporal choice of losses in adult attention-deficit hyperactivity disorder.

    PubMed

    Tanaka, Saori C; Yahata, Noriaki; Todokoro, Ayako; Kawakubo, Yuki; Kano, Yukiko; Nishimura, Yukika; Ishii-Takahashi, Ayaka; Ohtake, Fumio; Kasai, Kiyoto

    2018-04-30

    Impulsive behaviours are common symptoms of attention-deficit hyperactivity disorder (ADHD). Although previous studies have suggested functional models of impulsive behaviour, a full explanation of impulsivity in ADHD remains elusive. To investigate the detailed mechanisms behind impulsive behaviour in ADHD, we applied an economic intertemporal choice task involving gains and losses to adults with ADHD and healthy controls and measured brain activity by functional magnetic resonance imaging. In the intertemporal choice of future gains, we observed no behavioural or neural difference between the two groups. In the intertemporal choice of future losses, adults with ADHD exhibited higher discount rates than the control participants. Furthermore, a comparison of brain activity representing the sensitivity of future loss in the two groups revealed significantly lower activity in the striatum and higher activity in the amygdala in adults with ADHD than in controls. Our preliminary findings suggest that an altered size sensitivity to future loss is involved in apparent impulsive choice behaviour in adults with ADHD and shed light on the multifaceted impulsivity underlying ADHD.

  10. IRIS Toxicological Review of Diisononyl Phthalate (Dinp) (Preliminary Assessment Materials)

    EPA Science Inventory

    In August 2014, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for DINP to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in ...

  11. IRIS Toxicological Review of Dibutyl Phthalate (Dbp) (Preliminary Assessment Materials)

    EPA Science Inventory

    In January 2015, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for DBP to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in ...

  12. IRIS Toxicological Review of Diisobutyl Phthalate (Dibp) (Preliminary Assessment Materials)

    EPA Science Inventory

    In September 2014, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for DIBP to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested ...

  13. Academic physicians' opinions on preliminary reporting of echocardiographic data.

    PubMed

    McDonald, R W; Rice, M J; Reller, M D; Silberbach, G M; Imus, R L; Marcella, C P; Brazee, R B; Pantely, G A

    1993-01-01

    Preliminary reporting of echocardiographic data by cardiac sonographers has become a key issue in the echocardiography community. A survey on this issue was sent to 248 academic physicians and 89 (35.8%) were returned. In response to a question in the survey, 76 physicians stated that they had at least a limited amount of knowledge in echocardiography. For the group, 62% wanted a written or verbal preliminary report and 52% concluded that this report should be a part of the cardiac sonographer's position. If cardiac abnormalities are suspected, 65% wanted the results before the cardiologist reviewed the study, but only 42% of the physicians wanted a diagnostic versus a descriptive type of report. About 49% stated that if necessary they would attempt to influence the cardiac sonographer to give them a preliminary report, whereas 67% of the physicians would possibly use this information to medically manage the patient. Fifty percent believed that it was legal for a cardiac sonographer to give a preliminary report. Another 70% said that the cardiac sonographer would NOT be "practicing medicine without a license" and 66% concluded that they would NOT be "aiding and abetting the unauthorized practice of medicine" if given this information. These data have important potential ramifications for both cardiac sonographers as well as for the practice of cardiology regarding the issue of preliminary echocardiographic reports.

  14. Comparison of polygraph data obtained from individuals involved in mock crimes and actual criminal investigations.

    PubMed

    Pollina, Dean A; Dollins, Andrew B; Senter, Stuart M; Krapohl, Donald J; Ryan, Andrew H

    2004-12-01

    In a preliminary attempt to determine the generalizability of data from laboratory mock-crime studies, the authors examined the similarities and differences among the cardiovascular, electrodermal, and respiration responses of deceptive and nondeceptive individuals elicited to crime-relevant and crime-irrelevant questions. Participants in the laboratory group were randomly assigned to nondeceptive (n = 28) or deceptive (n = 27) treatment groups, and a mock-crime scenario was used. The field participants were confirmed nondeceptive (n = 28) or deceptive (n = 39) criminal suspects who underwent polygraph examinations between 1993 and 1997. The results indicated that there were salient differences between field and similarly obtained laboratory polygraph response measures. However, accuracy of laboratory participants' classifications using logistic regression analysis was not significantly different from field participants' classification accuracy. 2004 APA, all rights reserved

  15. When There Is Not Enough Evidence and When Evidence Is Not Enough: An Australian Indigenous Smoking Policy Study.

    PubMed

    Vujcich, Daniel; Rayner, Mike; Allender, Steven; Fitzpatrick, Ray

    2016-01-01

    The Indigenous Tobacco Control Initiative and Tackling Indigenous Smoking Measure were both announced by the Australian Government at a time when its rhetoric around the importance of evidence-based policy making was strong. This article will (1) examine how the Rudd Government used evidence in Indigenous tobacco control policy making and (2) explore the facilitators of and barriers to the use of evidence. Data were collected through (1) a review of primary documents largely obtained under the Freedom of Information Act 1982 (Commonwealth of Australia) and (2) interviews with senior politicians, senior bureaucrats, government advisors, Indigenous health advocates, and academics. Through the Freedom of Information Act process, 24 previously undisclosed government documents relevant to the making of Indigenous tobacco control policies were identified. Interviewees ( n  = 31, response rate 62%) were identified through both purposive and snowball recruitment strategies. The Framework Analysis method was used to analyze documentary and interview data. Government policy design was heavily influenced by the recommendations presented in government authored/commissioned literature reviews. Resulting policies were led by equivocal evidence for improved tobacco control outcomes among Indigenous Australians. Many of the cited studies had methodological limitations. In the absence of high-quality evidence, some policy makers supported policy recommendations that were perceived to be popular among the Indigenous community. Other policy makers recognized that there were barriers to accumulating rigorous, generalizable evidence; in the absence of such evidence, the policy makers considered that the "need for action" could be combined with the "need for research" by introducing innovative strategies and evaluating them. Despite the absence of high-quality evidence, the formulation and adoption of Indigenous tobacco policy was neither irrational nor reckless. The decision to

  16. Evidence-based Medicine in Pediatric Orthopaedics: Evidence-based Practice Committee Summary of Levels of Evidence, Clinical Practice Guidelines, Appropriate Use Criteria, and Best Practice Guidelines.

    PubMed

    Gandhi, Jigar S; Shea, Kevin G; Sponseller, Paul D; Brighton, Brian K; Ganley, Theodore J

    2018-04-30

    The concept of evidence-based medicine has evolved over the past 2 decades, and has become a cornerstone to clinical decision-making in virtually every aspect of medicine. With a commitment to providing its members with high-quality evidence-based guidelines, the American Academy of Orthopaedic Surgeons has instituted concerted efforts since 2006 to develop clinical practice guidelines (CPGs) and appropriate use criteria (AUCs) for certain orthopaedic conditions. Many of these CPGs and AUCs detail the management of pediatric orthopaedic conditions. By the same token, members of the Pediatric Orthopaedic Society of North America (POSNA) Evidence Based Practice Committee have been publishing succinct evaluations of randomized controlled trials in pediatric orthopaedic surgery to create an evidence-based repository for quick reference to available high-level evidence as well as resource to identify gaps in the current research and identify opportunities for future investigation. In instances where higher-level evidence needed to develop CPGs is not available to address a critically important clinical question, consensus recommendations from experts in the field have been obtained to develop best practice guidelines (BPGs). The purpose of this review is to provide readers with a deeper understanding of the key principles of evidence-based medicine and methodologies used for the development of CPGs, AUCs, and BPGs.

  17. School travel plans: preliminary evidence for changing school-related travel patterns in elementary school children.

    PubMed

    Hinckson, Erica A; Badland, Hannah M

    2011-01-01

    In New Zealand, the School Travel Plan (STP) program was developed to increase school-related active travel rates and decrease traffic congestion. The plan was developed through collaboration among the school, community, and local council. The STP was tailored to each school's specific needs and incorporated educational initiatives, physical infrastructural changes in the vicinity of schools, and policy development. The purpose of this study was to determine the effectiveness of the STP program in changing school travel modes in children. Effectiveness was assessed by determining the difference between pre-STP and follow-up travel mode data in schools. The differences were assessed using multilinear regression analysis, including decile (measure of socioeconomic status), school roll at baseline, and STP year of implementation as predictors. Thirty-three elementary schools from the Auckland region participated in the study. School size ranged from 130 to 688 students. The final 2006 sample consisted of 13,631 students. On a set day (pre- and post-STP), students indicated their mode of transport to school and intended mode for returning home that day. Differences are reported as percentage points: there was an increase in active transport by 5.9% ± 6.8% when compared to baseline travel modes. School roll, STP year of implementation, and baseline values predicted engagement with active transport. Preliminary findings suggest that the STP program may be successful in creating mode shift changes to favor school-related active travel in elementary-school children.

  18. Preliminary evaluation of synthetic speech

    DOT National Transportation Integrated Search

    1972-08-01

    The report briefly discusses the methods for storing and generating synthetic speech and a preliminary evaluation of the intelligibility of a speech synthesizer having a 75-word vocabulary selected for air traffic control messages. A program is sugge...

  19. IRIS Toxicological Review of Diethyl Phthalate (DEP) (Preliminary Assessment Materials)

    EPA Science Inventory

    In March 2014, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for DEP to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in co...

  20. Ultrastructural examination of broncho-alveolar lavage for diagnosis of pulmonary histiocytosis X: Preliminary report on 4 cases.

    PubMed Central

    Basset, F; Soler, P; Jaurand, M C; Bignon, J

    1977-01-01

    Fibreoptic broncho-alveolar lavage was used in four patients; the diagnosis of histiocytosis X had been established by lung biopsy in three and was suggested on clinical grounds in the remaining patient. Characteristic cells with an ultrastructural cytoplasmic marker (X body) were found in the washes of all four patients. In the patient without biopsy confirmation, the findings in the broncho-aleolar washes supplied the corroborating evidence for the diagnosis. From this preliminary study the technique seems able to provide a diagnosis in pulmonary histiocytosis X without the need for an open lung biopsy. Images PMID:302040

  1. Trapping para-Quinone Methide Intermediates with Ferrocene: Synthesis and Preliminary Biological Evaluation of New Phenol-Ferrocene Conjugates.

    PubMed

    González-Pelayo, Silvia; López, Enol; Borge, Javier; de-Los-Santos-Álvarez, Noemí; López, Luis A

    2018-06-01

    The reaction of para -hydroxybenzyl alcohols with ferrocene in the presence of a catalytic amount of InCl₃ provided ferrocenyl phenol derivatives, an interesting class of organometallic compounds with potential applications in medicinal chemistry. This transformation exhibited a reasonable substrate scope delivering the desired products in synthetically useful yields. Evidence of involvement of a para -quinone methide intermediate in this coupling process was also provided. Preliminary biological evaluation demonstrated that some of the ferrocene derivatives available by this methodology exhibit significant cytotoxicity against several cancer cell lines with IC 50 values within the range of 1.07⁻4.89 μM.

  2. NSLS-II Preliminary Design Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dierker, S.

    2007-11-01

    Following the CD0 approval of the National Synchrotron Light Source II (NSLS-II) during August 2005, Brookhaven National Laboratory prepared a conceptual design for a worldclass user facility for scientific research using synchrotron radiation. DOE SC review of the preliminary baseline in December 2006 led to the subsequent CD1 approval (approval of alternative selection and cost range). This report is the documentation of the preliminary design work for the NSLS-II facility. The preliminary design of the Accelerator Systems (Part 1) was developed mostly based of the Conceptual Design Report, except for the Booster design, which was changed from in-storage-ring tunnel configurationmore » to in external- tunnel configuration. The design of beamlines (Part 2) is based on designs developed by engineering firms in accordance with the specification provided by the Project. The conventional facility design (Part 3) is the Title 1 preliminary design by the AE firm that met the NSLS-II requirements. Last and very important, Part 4 documents the ES&H design and considerations related to this preliminary design. The NSLS-II performance goals are motivated by the recognition that major advances in many important technology problems will require scientific breakthroughs in developing new materials with advanced properties. Achieving this will require the development of new tools that will enable the characterization of the atomic and electronic structure, chemical composition, and magnetic properties of materials, at nanoscale resolution. These tools must be nondestructive, to image and characterize buried structures and interfaces, and they must operate in a wide range of temperatures and harsh environments. The NSLS-II facility will provide ultra high brightness and flux and exceptional beam stability. It will also provide advanced insertion devices, optics, detectors, and robotics, and a suite of scientific instruments designed to maximize the scientific output of the

  3. Preliminary studies of bio-oil from fast pyrolysis of coconut fibers.

    PubMed

    Almeida, Tarciana M; Bispo, Mozart D; Cardoso, Anne R T; Migliorini, Marcelo V; Schena, Tiago; de Campos, Maria Cecilia V; Machado, Maria Elisabete; López, Jorge A; Krause, Laiza C; Caramão, Elina B

    2013-07-17

    This work studied fast pyrolysis as a way to use the residual fiber obtained from the shells of coconut ( Cocos nucifera L. var. Dwarf, from Aracaju, northeastern Brazil). The bio-oil produced by fast pyrolysis and the aqueous phase (formed during the pyrolysis) were characterized by GC/qMS and GC×GC/TOF-MS. Many oxygenated compounds such as phenols, aldehydes, and ketones were identified in the extracts obtained in both phases, with a high predominance of phenolic compounds, mainly alkylphenols. Eighty-one compounds were identified in the bio-oil and 42 in the aqueous phase using GC/qMS, and 95 and 68 in the same samples were identified by GC×GC/TOF-MS. The better performance of GC×GC/TOF-MS was due to the possibility of resolving some coeluted peaks in the one-dimension gas chromatography. Semiquantitative analysis of the samples verified that 59% of the area on the chromatogram of bio-oil is composed by phenols and 12% by aldehydes, mainly furfural. Using the same criterion, 77% of the organic compounds in the aqueous phase are phenols. Therefore, this preliminary assessment indicates that coconut fibers have the potential to be a cost-effective and promising alternative to obtain new products and minimize environmental impact.

  4. Effect of the ultrasound-assisted preliminary maceration on the efficiency of the essential oil distillation from selected herbal raw materials.

    PubMed

    Kowalski, Radosław; Kowalska, Grażyna; Jamroz, Jerzy; Nawrocka, Agnieszka; Metyk, Damian

    2015-05-01

    The objective of the study was the estimation of the ultrasound-assisted preliminary maceration effect on the efficiency of essential oil distillation and on its qualitative and quantitative composition. The experiment included analyses on three herbal materials, i.e. peppermint leaves (Mentha piperita L.), marjoram herb (Origanum majorana L.), and chamomile flowers (Chamomilla recutita (L.) Rauschert). The study showed that the application of preliminary water maceration of raw material, augmented with ultrasounds, had a statistically significant increasing effect on the amount of oil distilled, in the case of mint leaf from 1.32% to 1.46% v/w, and in the case of marjoram herb from 1.13% to 1.27% v/w. In the case of chamomile flowers no significant effect of ultrasound on the amount of oil obtained was observed. Generally, comparing the composition of essential oils obtained in the experiments with the requirements of the relevant standards no unfavourable effect of the distillation augmenting techniques applied was noted. Therefore, it should be expected that the studied distillates of volatile fractions will have the desired biological activity. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. Costs to Community Mental Health Agencies to Sustain an Evidence-Based Practice.

    PubMed

    Roundfield, Katrina D; Lang, Jason M

    2017-09-01

    Dissemination of evidence-based practices (EBPs) has become a priority in children's mental health services. Although implementation approaches and initiatives are proliferating, little is known about sustainment of EBPs, but evidence suggests that most EBPs are not sustained for more than a few years. Cost is the most frequently cited barrier to sustainment, yet very little is known about these costs. This study provides a method for quantifying incremental costs of an EBP compared with usual care and preliminary data on the costs in staff time, lost revenue, and other expenses of sustaining an EBP (trauma-focused cognitive-behavioral therapy [TF-CBT]) in community mental health settings. Fourteen community mental health agencies (CMHAs) completed a measure developed for this study to collect administrative data on implementation costs to sustain TF-CBT. Survey items captured activities that were related specifically to TF-CBT and that would not otherwise be conducted for usual care, such as TF-CBT training. Staff time in hours was converted to monetary estimates. Costs varied widely across agencies. Preliminary results indicated that agencies spent on average $65,192 per year (2014 U.S.$) on incremental costs for TF-CBT sustainment (excluding costs of external trainers and other support); the average incremental cost per client was $1,896. The costs to sustain the EBP suggest that maintaining an EBP is a financial burden for CMHAs and that these costs can be a potential barrier to broader EBP uptake. Implications for public policy include providing reimbursement rates and financial incentives to offset potential implementation costs and promote sustainment of EBPs.

  6. Preliminary investigation of power flow and electrode phenomena in a multi-megawatt coaxial plasma thruster

    NASA Technical Reports Server (NTRS)

    Schoenberg, Kurt F.; Gerwin, Richard A.; Henins, Ivars; Mayo, Robert; Scheuer, Jay; Wurden, Glen

    1992-01-01

    The present report on preliminary results of theoretical and experimental investigations of power flow in a large, unoptimized, multimegawatt coaxial thruster evaluates the significance of these data for the development of efficient, megawatt-class magnetoplasmadynamic (MPD) thrusters. The good agreement obtained between thruster operational performance and model predictions suggests that ideal MHD processes, including those of a magnetic nozzle, play an important role in coaxial plasma thruster dynamics at power levels relevant to advanced space propulsion. An optimized magnetic nozzle design would aid the development of efficient, multimegawatt MPD thrusters.

  7. A Preliminary Study of Fuel Injection and Compression Ignition as Applied to an Aircraft Engine Cylinder

    NASA Technical Reports Server (NTRS)

    Gardiner, Arthur W

    1927-01-01

    This report summarizes some results obtained with a single cylinder test engine at the Langley Field Laboratory during a preliminary investigation of the problem of applying fuel injection and compression ignition to aircraft engines. For this work a standard Liberty Engine cylinder was fitted with a high compression, 11.4 : 1 compression ratio, piston, and equipped with an airless injection system, including a primary fuel pump, an injection pump, and an automatic injection valve. The results obtained during this investigation have indicated the possibility of applying airless injection and compression ignition to a cylinder of this size, 8-inch bore by 7-inch stroke, when operating at engine speeds as high as 1,850 R. P. M. A minimum specific fuel consumption with diesel engine fuel oil of 0.30 pound per I. HP. Hour was obtained when developing about 16 B. HP. At 1,730 R. P. M.

  8. Template-DTW based on inertial signals: Preliminary results for step characterization.

    PubMed

    Mantilla, Juan; Oudre, Laurent; Barrois, Remi; Vienne, Alienor; Ricard, Damien

    2017-07-01

    In this paper, we present a method for the creation of a library of inertial signals based on Dynamic Time Warping (DTW) for step characterization, with preliminary results in control subjects and patients with neurological diseases. Subjects performed a protocol including a 10 m straight walking, then turn back and walking for additional 10 m. The library is constructed with inertial signals (acceleration and angular velocities recorded in three directions) aligned with the DTW. Templates in the library are obtained for a specific cohort and for the different walking phases of the protocol. They are compared to the signal of a single subject by calculating a Pearson correlation coefficient. The method has been tested on a database of 864 exercises, obtained from 71 healthy controls, 24 patients with Parkinson disease and 48 patients with Radiation Induced Leukoencephalopathy (RIL). Pearson correlation classification reports a precision of about 85% for step detection. For exercise characterization the sensitivity is about 57%, 56% and 82% for Parkinson, RIL and control subjects respectively.

  9. Incident CTS in a large pooled cohort study: associations obtained by a Job Exposure Matrix versus associations obtained from observed exposures.

    PubMed

    Dale, Ann Marie; Ekenga, Christine C; Buckner-Petty, Skye; Merlino, Linda; Thiese, Matthew S; Bao, Stephen; Meyers, Alysha Rose; Harris-Adamson, Carisa; Kapellusch, Jay; Eisen, Ellen A; Gerr, Fred; Hegmann, Kurt T; Silverstein, Barbara; Garg, Arun; Rempel, David; Zeringue, Angelique; Evanoff, Bradley A

    2018-03-29

    There is growing use of a job exposure matrix (JEM) to provide exposure estimates in studies of work-related musculoskeletal disorders; few studies have examined the validity of such estimates, nor did compare associations obtained with a JEM with those obtained using other exposures. This study estimated upper extremity exposures using a JEM derived from a publicly available data set (Occupational Network, O*NET), and compared exposure-disease associations for incident carpal tunnel syndrome (CTS) with those obtained using observed physical exposure measures in a large prospective study. 2393 workers from several industries were followed for up to 2.8 years (5.5 person-years). Standard Occupational Classification (SOC) codes were assigned to the job at enrolment. SOC codes linked to physical exposures for forceful hand exertion and repetitive activities were extracted from O*NET. We used multivariable Cox proportional hazards regression models to describe exposure-disease associations for incident CTS for individually observed physical exposures and JEM exposures from O*NET. Both exposure methods found associations between incident CTS and exposures of force and repetition, with evidence of dose-response. Observed associations were similar across the two methods, with somewhat wider CIs for HRs calculated using the JEM method. Exposures estimated using a JEM provided similar exposure-disease associations for CTS when compared with associations obtained using the 'gold standard' method of individual observation. While JEMs have a number of limitations, in some studies they can provide useful exposure estimates in the absence of individual-level observed exposures. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  10. Evidence for S-adenosyl-L-methionine (SAM-e) for the treatment of major depressive disorder.

    PubMed

    Papakostas, George I

    2009-01-01

    Despite the increasingly large array of antidepressants available to treat major depressive disorder, patients continue to experience relatively modest response and remission rates. In addition, patients may experience adverse side effects from pharmacotherapy that not only hinder treatment compliance and adherence but, in some cases, may also contribute to increased disability, patient suffering, morbidity, and mortality. In order to enhance treatment efficacy and tolerability, patients and clinicians have become increasingly interested in nonpharmaceutical supplements for treating depression. One of the best-studied of these supplements is S-adenosyl-L-methionine (SAM-e), a naturally occurring molecule present in all living cells and a major methyl group donor in the human body. Controlled trials have found SAM-e to be more efficacious than placebo and equal in efficacy to the tricyclic antidepressants for treating major depressive disorder (MDD) when administered parenterally (either intravenously or intramuscularly). Less evidence supports the use of oral SAM-e, although some trials have demonstrated its efficacy as well. In addition, there is a paucity of evidence examining whether oral forms of SAM-e can be safe, well tolerated, and efficacious when used as adjunctive treatment for antidepressant nonresponders with MDD. Although preliminary data suggest SAM-e may be useful as an adjunctive therapy to antidepressants, controlled studies are needed to confirm or refute these preliminary findings. (c) Copyright 2009 Physicians Postgraduate Press, Inc.

  11. Preliminary Measurements of Thin Film Solar Cells

    NASA Image and Video Library

    1967-06-21

    George Mazaris, works with an assistant to obtain the preliminary measurements of cadmium sulfide thin-film solar cells being tested in the Space Environmental Chamber at the National Aeronautics and Space Administration (NASA) Lewis Research Center. Lewis’ Photovoltaic Fundamentals Section was investigating thin-film alternatives to the standard rigid and fragile solar cells. The cadmium sulfide semiconductors were placed in a light, metallized substrate that could be rolled or furled during launch. The main advantage of the thin-film solar cells was their reduced weight. Lewis researchers, however, were still working on improving the performance of the semiconductor. The new thin-film solar cells were tested in a space simulation chamber in the CW-6 test cell in the Engine Research Building. The chamber created a simulated altitude of 200 miles. Sunlight was simulated by a 5000-watt xenon light. Some two dozen cells were exposed to 15 minutes of light followed by 15 minutes of darkness to test their durability in the constantly changing illumination of Earth orbit. This photograph was taken for use in a NASA recruiting publication.

  12. 1986 traffic fatalities, preliminary report

    DOT National Transportation Integrated Search

    1987-04-01

    This report provides a number of preliminary estimate of traffic fatalities and fatal accidents for 1986. Trend data are presented for both the long and short term. Some summary statistics are provided at the State and Regional level. The national es...

  13. [The preliminary assessment in the B-BS protocol as a tool for the discovery of job stress symptoms and contingencies: a method under experimentation by INAIL].

    PubMed

    Clerici, P; Guercio, A

    2010-01-01

    The proposed model is aimed at assessing work-related stress and consists of a preliminary phase during which the Organization is monitored, Indexes and stressors are defined, characterized and then weighted; existing symptoms (if any) are also identified. A 'Probability vs. Severity' Matrix is then built up as a result: these tasks can profitably be performed by a technical professional, typically the Responsible of the Safety and Health Committee. According to found evidences, a second phase, strictly based upon the application of psychosocial research tools, might be needed to investigate group of workers that resulted troublesome during the preliminary phase. The preliminary phase of investigation on organizational stressors and indexes can be easily and successfully integrated with the 'Safety Assessment' steps provided for the B-BS protocol, also aimed at monitoring the organizational wellbeing and consequently acting on the workers' behavior. The model has been specifically designed for Small and Medium Enterprises, with the global objective of preventing accidents at work due to misbehavior and distraction, by correctly and safely applying operational procedures and mutual relationships.

  14. 28 CFR 36.604 - Procedure following preliminary determination of equivalency.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... State Laws or Local Building Codes § 36.604 Procedure following preliminary determination of equivalency... of the preliminary determination of equivalency with respect to the particular code, and invite... enforcement of the code, at which interested individuals, including individuals with disabilities, are...

  15. 28 CFR 36.604 - Procedure following preliminary determination of equivalency.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... State Laws or Local Building Codes § 36.604 Procedure following preliminary determination of equivalency... of the preliminary determination of equivalency with respect to the particular code, and invite... enforcement of the code, at which interested individuals, including individuals with disabilities, are...

  16. 28 CFR 36.604 - Procedure following preliminary determination of equivalency.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... State Laws or Local Building Codes § 36.604 Procedure following preliminary determination of equivalency... of the preliminary determination of equivalency with respect to the particular code, and invite... enforcement of the code, at which interested individuals, including individuals with disabilities, are...

  17. 28 CFR 36.604 - Procedure following preliminary determination of equivalency.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... State Laws or Local Building Codes § 36.604 Procedure following preliminary determination of equivalency... of the preliminary determination of equivalency with respect to the particular code, and invite... enforcement of the code, at which interested individuals, including individuals with disabilities, are...

  18. Comparison-Bot: an Automated Preliminary-Final Report Comparison System.

    PubMed

    Kalaria, Amit D; Filice, Ross W

    2016-06-01

    Regular comparison of preliminary to final reports is a critical part of radiology resident and fellow education as prior research has documented substantial preliminary to final discrepancies. Unfortunately, there are many barriers to this comparison: high study volume; overnight rotations without an attending; the ability to finalize reports remotely; the subtle nature of many changes; and lack of easy access to the preliminary report after finalization. We developed a system that automatically compiles and emails a weekly summary of report differences for all residents and fellows. Trainees can also create a custom report using a date range of their choice and can view this data on a resident dashboard. Differences between preliminary and final reports are clearly highlighted with links to the associated study in Picture Archiving and Communication Systems (PACS) for efficient review and learning. Reports with more changes, particularly changes made in the impression, are highlighted to focus attention on those exams with substantive edits. Our system provides an easy way for trainees to review changes to preliminary reports with immediate access to the associated images, thereby improving their educational experience. Departmental surveys showed that our report difference summary is easy to understand and improves the educational experience of our trainees. Additionally, interesting descriptive statistics help us understand how reports are changed by trainee level, by attending, and by exam type. Finally, this system can be easily ported to other departments who have access to their Health Level 7 (HL7) data.

  19. 20 CFR 30.907 - Can an impairment evaluation obtained by OWCP be challenged prior to issuance of the recommended...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Can an impairment evaluation obtained by OWCP... ILLNESS COMPENSATION PROGRAM ACT OF 2000, AS AMENDED Impairment Benefits Under Part E of EEOICPA Medical Evidence of Impairment § 30.907 Can an impairment evaluation obtained by OWCP be challenged prior to...

  20. Training Community Mental Health Therapists to Deliver a Package of Evidence-Based Practice Strategies for School-Age Children with Autism Spectrum Disorders: A Pilot Study

    ERIC Educational Resources Information Center

    Brookman-Frazee, Lauren I.; Drahota, Amy; Stadnick, Nicole

    2012-01-01

    Research on moving evidence-based practice (EBP) intervention strategies to community service settings for children with autism spectrum disorders (ASD) is urgently needed. The current pilot study addresses this need by examining the feasibility, acceptability and preliminary outcomes of training therapists practicing in community mental health…

  1. Mass transport phenomena in microgravity: Preliminary results of the first MEPHISTO flight experiment

    NASA Technical Reports Server (NTRS)

    Favier, Jean Jacques; Garandet, J. P.; Rouzaud, A.; Camel, D.

    1994-01-01

    The MEPHISTO space program is the result of a cooperative effort that involves the French nuclear and space agencies (Commissariat a l'energie atomique, CEA - Centre National d'Etudes Spatiales, CNES) and the American National Aeronautics and Space Administration (NASA). The scientific studies and apparatus development were funded in the frame of the GRAMME agreement between CEA and CNES, the flight costs being taken in charge by NASA. Six flight opportunities are scheduled, with alternating French and American principal investigators. It is the purpose of this paper to briefly present MEPHISTO along with the preliminary results obtained during its first flight on USMP-1 in October 1992.

  2. Preliminary data from a randomized pilot study of web-based functional analytic psychotherapy therapist training.

    PubMed

    Kanter, Jonathan W; Tsai, Mavis; Holman, Gareth; Koerner, Kelly

    2013-06-01

    Therapists of many persuasions emphasize the therapy relationship in their work, a priority backed by strong empirical evidence. Training in how to maximize the power and potential of the therapy relationship, however, has lagged behind. A novel approach to using the therapy relationship and to training therapists in its use is provided by Functional Analytic Psychotherapy (FAP). FAP training involves eight 2-hr weekly training sessions conducted online using web-conferencing technology. The training integrates behavioral principles with a focus on trainee-trainer and trainee-trainee relationships in a highly structured course that evokes the desirable FAP therapist-trainee behaviors and collectively shapes the behaviors through reinforcement by the trainer and other trainees. In a preliminary study, 16 therapist-trainees were randomly assigned to receive either immediate FAP training or training after a waitlist period. Significant and large effects of training were found on both self-reported and observer-assessed measures for the first training group, and the waitlist training group replicated the first training group with significant within-subject change over the course of training. Finally, qualitative feedback from therapists indicated high satisfaction with the primary elements of the training protocol. Several important limitations to this preliminary study are discussed.

  3. Preliminary study of the use of radiotracers for leak detection in industrial applications

    NASA Astrophysics Data System (ADS)

    Wetchagarun, S.; Petchrak, A.; Tippayakul, C.

    2015-05-01

    One of the most widespread uses of radiotracers in the industrial applications is the leak detection of the systems. This technique can be applied, for example, to detect leak in heat exchangers or along buried industrial pipelines. The ability to perform online investigation is one of the most important advantages of the radiotracer technique over other non-radioactive leak detection methods. In this paper, a preliminary study of the leak detection using radiotracer in the laboratory scale was presented. Br-82 was selected for this work due to its chemical property, its suitable half-life and its on-site availability. The NH4Br in the form of aqueous solution was injected into the experimental system as the radiotracer. Three NaI detectors were placed along the pipelines to measure system flow rate and to detect the leakage from the piping system. The results obtained from the radiotracer technique were compared to those measured by other methods. It is found that the flow rate obtained from the radiotracer technique agreed well with the one obtained from the flow meter. The leak rate result, however, showed discrepancy between results obtained from two different measuring methods indicating further study on leak detection was required before applying this technique in the industrial system.

  4. Preliminary design package for prototype solar heating system

    NASA Technical Reports Server (NTRS)

    1978-01-01

    A summary is given of the preliminary analysis and design activity on solar heating systems. The analysis was made without site specific data other than weather; therefore, the results indicate performance expected under these special conditions. Major items include system candidates, design approaches, trade studies and other special data required to evaluate the preliminary analysis and design. The program calls for the development and delivery of eight prototype solar heating and cooling systems for installation and operational test.

  5. Preliminary estimates of spatially distributed net infiltration and recharge for the Death Valley region, Nevada-California

    USGS Publications Warehouse

    Hevesi, J.A.; Flint, A.L.; Flint, L.E.

    2002-01-01

    A three-dimensional ground-water flow model has been developed to evaluate the Death Valley regional flow system, which includes ground water beneath the Nevada Test Site. Estimates of spatially distributed net infiltration and recharge are needed to define upper boundary conditions. This study presents a preliminary application of a conceptual and numerical model of net infiltration. The model was developed in studies at Yucca Mountain, Nevada, which is located in the approximate center of the Death Valley ground-water flow system. The conceptual model describes the effects of precipitation, runoff, evapotranspiration, and redistribution of water in the shallow unsaturated zone on predicted rates of net infiltration; precipitation and soil depth are the two most significant variables. The conceptual model was tested using a preliminary numerical model based on energy- and water-balance calculations. Daily precipitation for 1980 through 1995, averaging 202 millimeters per year over the 39,556 square kilometers area of the ground-water flow model, was input to the numerical model to simulate net infiltration ranging from zero for a soil thickness greater than 6 meters to over 350 millimeters per year for thin soils at high elevations in the Spring Mountains overlying permeable bedrock. Estimated average net infiltration over the entire ground-water flow model domain is 7.8 millimeters per year.To evaluate the application of the net-infiltration model developed on a local scale at Yucca Mountain, to net-infiltration estimates representing the magnitude and distribution of recharge on a regional scale, the net-infiltration results were compared with recharge estimates obtained using empirical methods. Comparison of model results with previous estimates of basinwide recharge suggests that the net-infiltration estimates obtained using this model may overestimate recharge because of uncertainty in modeled precipitation, bedrock permeability, and soil properties for

  6. Modeling Sensor Reliability in Fault Diagnosis Based on Evidence Theory

    PubMed Central

    Yuan, Kaijuan; Xiao, Fuyuan; Fei, Liguo; Kang, Bingyi; Deng, Yong

    2016-01-01

    Sensor data fusion plays an important role in fault diagnosis. Dempster–Shafer (D-R) evidence theory is widely used in fault diagnosis, since it is efficient to combine evidence from different sensors. However, under the situation where the evidence highly conflicts, it may obtain a counterintuitive result. To address the issue, a new method is proposed in this paper. Not only the statistic sensor reliability, but also the dynamic sensor reliability are taken into consideration. The evidence distance function and the belief entropy are combined to obtain the dynamic reliability of each sensor report. A weighted averaging method is adopted to modify the conflict evidence by assigning different weights to evidence according to sensor reliability. The proposed method has better performance in conflict management and fault diagnosis due to the fact that the information volume of each sensor report is taken into consideration. An application in fault diagnosis based on sensor fusion is illustrated to show the efficiency of the proposed method. The results show that the proposed method improves the accuracy of fault diagnosis from 81.19% to 89.48% compared to the existing methods. PMID:26797611

  7. Community Collaborations and Youth Development: Preliminary Findings on the State of the Evidence. Research Brief Series

    ERIC Educational Resources Information Center

    Center for Promise, 2013

    2013-01-01

    In 2004, the Aspen Institute Roundtable on Community Change emphasized the need for a comprehensive base of information on the effectiveness of community collaborations for youth--an accessible, evidence-rich resource that could guide local efforts to bring about meaningful change. Nearly 10 years later, this need remains largely unmet. In…

  8. Preliminary assessments of CO2 storage in carbonate formations: a case study from Malaysia

    NASA Astrophysics Data System (ADS)

    Raza, Arshad; Gholami, Raoof; Rezaee, Reza; Bing, Chua Han; Nagarajan, Ramasamy; Hamid, Mohamed Ali

    2017-06-01

    The preliminary assessment of depleted reservoirs prior to the injection of CO2 is an essential step to ensure the safety and success of storage projects. Several studies have provided a preliminary assessment of depleted reservoirs as a sequestration practice. However, the screening criteria used in these studies were not able to consider all of the aspects of a storage site. The aim of this paper is to provide a reservoir-scale evaluation approach for long-term storage practice in an offshore carbonate field located in Malaysia. Recently developed screening criteria that cover the key aspects of storage sites, such as capacity, injectivity, trapping mechanisms, and containment, are taken into consideration for the purpose of this study. The results obtained suggest that the reservoir has good potential to be a storage place for CO2, although the compaction behavior and aquifer supports of the reservoir might cause some difficulties. It is, therefore, recommended that a series of experimental and numerical studies on different aspects of storage sites be performed to ensure that injectivity is not a problem when it comes to the implementation stage.

  9. Reversing the mere exposure effect in spider fearfuls: Preliminary evidence of sensitization.

    PubMed

    Becker, Eni S; Rinck, Mike

    2016-12-01

    A mere exposure effect (MEE) is said to occur when individuals' liking of a suboptimally and repeatedly presented stimulus increases compared to never-presented stimuli, while they are unable to indicate which stimuli were previously presented and which were not. In two experiments, we used the MEE to study automatic evaluative processes in highly spider-fearful individuals (SFs). Pictures of spiders and butterflies were repeatedly presented suboptimally to SFs and to non-anxious controls (NACs). In Experiment 1, both groups showed the MEE for butterflies, preferring previously presented butterfly pictures over new ones. For spider pictures, only NACs showed an MEE, whereas SFs showed no preference. Experiment 2 involved a more unpleasant presentation situation, because for each picture, participants had the difficult task to indicate what had been presented to them. This led to a reversed MEE for spiders in SFs: They preferred new spider pictures over previously presented ones. In both experiments, no evidence was observed for the ability to differentiate between old an new pictures. The results are tentatively explained within Zajonc' theory of the MEE, and they are related to the concept of sensitization in anxiety disorders. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Precursors to Natural Grammar Learning: Preliminary Evidence from 4-Month-Old Infants

    PubMed Central

    Friederici, Angela D.; Mueller, Jutta L.; Oberecker, Regine

    2011-01-01

    When learning a new language, grammar—although difficult—is very important, as grammatical rules determine the relations between the words in a sentence. There is evidence that very young infants can detect rules determining the relation between neighbouring syllables in short syllable sequences. A critical feature of all natural languages, however, is that many grammatical rules concern the dependency relation between non-neighbouring words or elements in a sentence i.e. between an auxiliary and verb inflection as in is singing. Thus, the issue of when and how children begin to recognize such non-adjacent dependencies is fundamental to our understanding of language acquisition. Here, we use brain potential measures to demonstrate that the ability to recognize dependencies between non-adjacent elements in a novel natural language is observable by the age of 4 months. Brain responses indicate that 4-month-old German infants discriminate between grammatical and ungrammatical dependencies in auditorily presented Italian sentences after only brief exposure to correct sentences of the same type. As the grammatical dependencies are realized by phonologically distinct syllables the present data most likely reflect phonologically based implicit learning mechanisms which can serve as a precursor to later grammar learning. PMID:21445341

  11. Preliminary Opto-Mechanical Design for the X2000 Transceiver

    NASA Technical Reports Server (NTRS)

    Hemmati, H.; Page, N. A.

    2000-01-01

    Preliminary optical design and mechanical conceptual design for a 30 cm aperture transceiver are described. A common aperture is used for both transmit and receive. Special attention was given to off-axis and scattered light rejection and isolation of the receive channel from the transmit channel. Requirements, details of the design and preliminary performance analysis of the transceiver are provided.

  12. 78 FR 34644 - Stainless Steel Plate in Coils From Belgium: Preliminary Results of Antidumping Duty...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ... Coils From Belgium: Preliminary Results of Antidumping Duty Administrative Review; 2011-2012 AGENCY... of the scope of the order, see the ``Decision Memorandum for the Preliminary Results of Antidumping... Preliminary Decision Memorandum are identical in content. Preliminary Results of the Review As a result of...

  13. Augmented Reality Robot-assisted Radical Prostatectomy: Preliminary Experience.

    PubMed

    Porpiglia, Francesco; Fiori, Cristian; Checcucci, Enrico; Amparore, Daniele; Bertolo, Riccardo

    2018-05-01

    To present our preliminary experience with augmented reality robot-assisted radical prostatectomy (AR-RARP). From June to August 2017, patients candidate to RARP were enrolled and underwent high-resolution multi-parametric magnetic resonance imaging (1-mm slices) according to dedicated protocol. The obtained three-dimensional (3D) reconstruction was integrated in the robotic console to perform AR-RARP. According to the staging at magnetic resonance imaging or reconstruction, in case of cT2 prostate cancer, intrafascial nerve sparing (NS) was performed: a mark was placed on the prostate capsule to indicate the virtual underlying intraprostatic lesion; in case of cT3, standard NS AR-RARP was scheduled with AR-guided biopsy at the level of suspected extracapsular extension (ECE). Prostate specimens were scanned to assess the 3D model concordance. Sixteen patients underwent intrafascial NS technique (cT2), whereas 14 underwent standard NS+ selective biopsy of suspected ECE (cT3). Final pathology confirmed clinical staging. Positive surgical margins' rate was 30% (no positive surgical margins in pT2). In patients whose intraprostatic lesions were marked, final pathology confirmed lesion location. In patients with suspected ECE, AR-guided selective biopsies confirmed the ECE location, with 11 of 14 biopsies (78%) positive for prostate cancer. Prostate specimens were scanned with finding of a good overlap. The mismatch between 3D reconstruction and scanning ranged from 1 to 5 mm. In 85% of the entire surface, the mismatch was <3 mm. In our preliminary experience, AR-RARP seems to be safe and effective. The accuracy of 3D reconstruction seemed to be promising. This technology has still limitations: the virtual models are manually oriented and rigid. Future collaborations with bioengineers will allow overcoming these limitations. Copyright © 2018 Elsevier Inc. All rights reserved.

  14. Preliminary Results From a Laboratory Study of Positive Streamer Discharges on Simulated Ice Hydrometeors

    NASA Astrophysics Data System (ADS)

    Petersen, D.; Bailey, M.; Hallett, J.; Beasley, W.

    2007-12-01

    The initiation of lightning remains an open question, due in large part to a deficit of in-situ observational evidence. Recent theoretical descriptions of lightning initiation have focused on runaway breakdown and related secondary processes, but have not convincingly explained the details of onset of the embryonic lightning leader channel. Among possible mechanisms contributing to the initial leader formation are positive streamer discharges from ice hydrometeors, themselves once favored as the primary explanation of lightning initiation. We present preliminary results from a new laboratory study of positive streamer discharges on simulated ice hydrometeors. Emphasis is given to precisely defining the minimum electric field strength required for onset of positive streamer generation, with variables of interest being ice crystal size, habit and environmental temperature.

  15. Prevention of post-rape psychopathology: preliminary findings of a controlled acute rape treatment study.

    PubMed

    Resnick, H; Acierno, R; Holmes, M; Kilpatrick, D G; Jager, N

    1999-01-01

    Violent sexual assault such as rape typically results in extremely high levels of acute distress. The intensity of these acute psychological reactions may play a role in later recovery, with higher levels of immediate distress associated with poorer outcome. Unfortunately, post-rape forensic evidence collection procedures may serve to increase, rather than reduce initial distress, potentially exacerbating future psychopathology. To address these concerns, an acute time-frame hospital-based video intervention was developed to: (a) minimize anxiety during forensic rape exams, and (b) prevent post-rape posttraumatic stress disorder (PTSD), panic, and anxiety. Preliminary data indicated that (1) psychological distress at the time of the exam was strongly related to PTSD symptomatology 6 weeks post-rape, and (2) the video intervention successfully reduced distress during forensic exams.

  16. Polyethyleneimine patterns obtained by laser-transfer assisted by a Dynamic Release Layer onto Themanox soft substrates for cell adhesion study

    NASA Astrophysics Data System (ADS)

    Dinca, V.; Mattle, T.; Palla Papavlu, A.; Rusen, L.; Luculescu, C.; Lippert, T.; Dinescu, M.

    2013-08-01

    The use of LIFT (Laser Induced Forward Transfer) for localized and high spatial resolution printing of many types of functional organic and inorganic, biological or synthetic materials onto substrates is an effective method in various domains (electronics, sensors, and surface biofunctionalization). Although extensive research has been dedicated to the LIFT process in the last years, there is an increasing interest for combining the advantages of this technique with specific materials characteristics for obtaining localized structures or for creating physical guidance structures that could be used as biological scaffolds. Within this context, we aim to study a new aspect related to combining the advantages of Dynamic Release Layer assisted LIFT (DRL-LIFT) with a soft substrate (i.e. Thermanox) for obtaining surface functionalization with micro and nano "porous" polymeric structures. The structures obtained with different topographical properties were evaluated by scanning electron microscopy, atomic force microscopy, optical and fluorescence microscopy. Subsequently, the structures were used as a base for cellular behavior study platforms. Preliminary in vitro tests involving two types of cells, fibroblast and oligodendrocytes, were performed on these LIFT printed platforms.

  17. Preliminary analysis of strong-motion recordings from the 28 September 2004 Parkfield, California earthquake

    USGS Publications Warehouse

    Shakal, A.; Graizer, V.; Huang, M.; Borcherdt, R.; Haddadi, H.; Lin, K.-W.; Stephens, C.; Roffers, P.

    2005-01-01

    The Parkfield 2004 earthquake yielded the most extensive set of strong-motion data in the near-source region of a magnitude 6 earthquake yet obtained. The recordings of acceleration and volumetric strain provide an unprecedented document of the near-source seismic radiation for a moderate earthquake. The spatial density of the measurements alon g the fault zone and in the linear arrays perpendicular to the fault is expected to provide an exceptional opportunity to develop improved models of the rupture process. The closely spaced measurements should help infer the temporal and spatial distribution of the rupture process at much higher resolution than previously possible. Preliminary analyses of the peak a cceleration data presented herein shows that the motions vary significantly along the rupture zone, from 0.13 g to more than 2.5 g, with a map of the values showing that the larger values are concentrated in three areas. Particle motions at the near-fault stations are consistent with bilateral rupture. Fault-normal pulses similar to those observed in recent strike-slip earthquakes are apparent at several of the stations. The attenuation of peak ground acceleration with distance is more rapid than that indicated by some standard relationships but adequately fits others. Evidence for directivity in the peak acceleration data is not strong. Several stations very near, or over, the rupturing fault recorded relatively low accelerations. These recordings may provide a quantitative basis to understand observations of low near-fault shaking damage that has been reported in other large strike-slip earthquak.

  18. 19 CFR 351.205 - Preliminary determination.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Introduction. A preliminary determination in an antidumping or countervailing duty investigation constitutes... short life cycle merchandise (see section 733(b)(1)(B) and section 739 of the Act). (c) Contents of...

  19. Preliminary Effectiveness Study of Coping Power Program for Aggressive Children in Pakistan.

    PubMed

    Mushtaq, Asia; Lochman, John E; Tariq, Pervaiz N; Sabih, Fazaila

    2017-10-01

    Aggression is a characteristic feature of many psychiatric disorders. To address the scarceness for evidence-based interventions for behavioral problems in Pakistan, we evaluated the effectiveness of culturally adapted version of Coping Power Program. The purpose of the study was to determine the extent to which Coping Power Program is capable of reducing aggressive behavior and improving competent behavior, when delivered in a different culture, i.e., Pakistan. With randomized control trial (RCT) of pre- and post-testing, 112 fourth grade boys were allocated to Coping Power intervention condition and waitlist control condition. The intervention group showed significant reduction in aggression at post assessment, in comparison to control group. Boys who received Coping Power intervention also showed improvements in behavior, social skills, and social cognitive processes, with better anger control and problem solving strategies, in comparison to the control group. The results of the study provide preliminary evidence, supporting the effectiveness of Coping Power Program for Pakistani children. Despite its limitations, the results of this study are promising and suggest that Coping Power is an effective intervention to reduce behavioral problems and promote healthy and positive behaviors in children, even when implemented in different contexts with greater potential for violence exposure.

  20. IRIS Toxicological Review of Butyl Benzyl Phthalate (Bbp) (Preliminary Assessment Materials)

    EPA Science Inventory

    In September 2014, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for BBP to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested i...

  1. A systematic literature search on psychological first aid: lack of evidence to develop guidelines.

    PubMed

    Dieltjens, Tessa; Moonens, Inge; Van Praet, Koen; De Buck, Emmy; Vandekerckhove, Philippe

    2014-01-01

    Providing psychological first aid (PFA) is generally considered to be an important element in preliminary care of disaster victims. Using the best available scientific basis for courses and educational materials, the Belgian Red Cross-Flanders wants to ensure that its volunteers are trained in the best way possible. To identify effective PFA practices, by systematically reviewing the evidence in existing guidelines, systematic reviews and individual studies. Systematic literature searches in five bibliographic databases (MEDLINE, PsycINFO, The Cochrane Library, PILOTS and G-I-N) were conducted from inception to July 2013. Five practice guidelines were included which were found to vary in the development process (AGREE II score 20-53%) and evidence base used. None of them provides solid evidence concerning the effectiveness of PFA practices. Additionally, two systematic reviews of PFA were found, both noting a lack of studies on PFA. A complementary search for individual studies, using a more sensitive search strategy, identified 11 237 references of which 102 were included for further full-text examination, none of which ultimately provides solid evidence concerning the effectiveness of PFA practices. The scientific literature on psychological first aid available to date, does not provide any evidence about the effectiveness of PFA interventions. Currently it is impossible to make evidence-based guidelines about which practices in psychosocial support are most effective to help disaster and trauma victims.

  2. [The use of the internal tissue expansion procedure in reconstructive surgery. Preliminary study and report of 2 cases].

    PubMed

    Horn, G

    1997-12-01

    The Frechet extender, initially proposed and successfully used in scalp reductions, can have many other indications in reconstructive surgery. This paper describes the preliminary results obtained after using this internal tissue extender in the treatment of a limb burn scar and a congenital giant naevus of the back. After a 3 month follow-up, these results are excellent. This procedure gives good results especially when there is a bony support underneath the skin to be treated.

  3. A preliminary double-blind, placebo-controlled randomized study of baclofen effects in alcoholic smokers

    PubMed Central

    Zywiak, William H.; Edwards, Steven M.; Tidey, Jennifer W.; Swift, Robert M.; Kenna, George A.

    2014-01-01

    Rationale There is presently no approved single treatment for dual alcohol and nicotine dependencies. Objective This pilot study investigated baclofen effects in alcoholic smokers. Methods This was a preliminary double-blind placebo-controlled randomized clinical study with 30 alcoholic smokers randomized to baclofen at 80 mg/day or placebo. A subgroup (n=18) participated in an alcohol cue-reactivity experiment. Results Baclofen, compared with placebo, significantly decreased the percent days of abstinence from alcohol-tobacco co-use (p=0.004). Alcohol dependence severity moderated baclofen effects, with the higher severity group having the greater baclofen response (p<0.001). Although the percent days of alcohol-tobacco co-use declined in both groups, this decline was greater after placebo than baclofen (p<0.001). Secondary analyses on alcohol or tobacco use alone suggested that the increase in percent days of co-abstinence was driven by the medication differences on heavy drinking days and on percent days smoking. In the cue-reactivity substudy, baclofen slightly decreased alcohol urge (p=0.058) and significantly reduced salivation (p=0.001), but these effects were not related to cue type. Conclusions This study provides preliminary evidence suggesting a possible role of baclofen in the treatment of alcoholic smokers. However, the mixed results and the small sample require larger confirmatory studies. PMID:24973894

  4. Obtaining real-world evidence: the Salford Lung Study

    PubMed Central

    New, John P; Bakerly, Nawar Diar; Leather, David; Woodcock, Ashley

    2014-01-01

    We need to assess clinical treatments in real-life settings outside of randomised controlled trials (RCTs). Pragmatic RCT (pRCT) data can supplement RCTs by providing effectiveness information to support healthcare decisions. Electronic health records can facilitate concurrent safety monitoring and data collection without direct patient contact for large randomised study populations in pRCTs. The Salford Lung Study is the world's first phase III pRCT in asthma and chronic obstructive pulmonary disease (COPD), which aims to randomise over 7000 patients. This paper describes the hurdles overcome and the enormous effort and resource required to establish this comparative effectiveness study of a prelicence intervention. GlaxoSmithKline protocol HZC115151 Asthma study clinicaltrials.gov registration NCT01706198 COPD study clinicaltrials.gov registration NCT01551758 PMID:24603195

  5. 28 CFR 36.605 - Procedure following preliminary denial of certification.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Local Building Codes § 36.605 Procedure following preliminary denial of certification. (a) If the Assistant Attorney General makes a preliminary determination to deny certification of a code under § 36.603... specification of the manner in which the code could be amended in order to qualify for certification. (b) The...

  6. 28 CFR 36.605 - Procedure following preliminary denial of certification.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Local Building Codes § 36.605 Procedure following preliminary denial of certification. (a) If the Assistant Attorney General makes a preliminary determination to deny certification of a code under § 36.603... specification of the manner in which the code could be amended in order to qualify for certification. (b) The...

  7. 28 CFR 36.605 - Procedure following preliminary denial of certification.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Local Building Codes § 36.605 Procedure following preliminary denial of certification. (a) If the Assistant Attorney General makes a preliminary determination to deny certification of a code under § 36.603... specification of the manner in which the code could be amended in order to qualify for certification. (b) The...

  8. 28 CFR 36.605 - Procedure following preliminary denial of certification.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Local Building Codes § 36.605 Procedure following preliminary denial of certification. (a) If the Assistant Attorney General makes a preliminary determination to deny certification of a code under § 36.603... specification of the manner in which the code could be amended in order to qualify for certification. (b) The...

  9. 32 CFR 644.392 - Air Force-preliminary report of excess.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Air Force-preliminary report of excess. 644.392 Section 644.392 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Disposal Predisposal Action § 644.392 Air Force—preliminary report of excess...

  10. 28 CFR 36.606 - Procedure following preliminary denial of certification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Local Building Codes § 36.606 Procedure following preliminary denial of certification. (a) If the Assistant Attorney General makes a Preliminary determination to deny certification of a code under § 36.604... specification of the manner in which the code could be amended in order to qualify for certification. (b) The...

  11. Recruiting for values in healthcare: a preliminary review of the evidence.

    PubMed

    Patterson, Fiona; Prescott-Clements, Linda; Zibarras, Lara; Edwards, Helena; Kerrin, Maire; Cousans, Fran

    2016-10-01

    Displaying compassion, benevolence and respect, and preserving the dignity of patients are important for any healthcare professional to ensure the provision of high quality care and patient outcomes. This paper presents a structured search and thematic review of the research evidence relating to values-based recruitment within healthcare. Several different databases, journals and government reports were searched to retrieve studies relating to values-based recruitment published between 1998 and 2013, both in healthcare settings and other occupational contexts. There is limited published research related to values-based recruitment directly, so the available theoretical context of values is explored alongside an analysis of the impact of value congruence. The implications for the design of selection methods to measure values is explored beyond the scope of the initial literature search. Research suggests some selection methods may be appropriate for values-based recruitment, such as situational judgment tests (SJTs), structured interviews and multiple-mini interviews (MMIs). Personality tests were also identified as having the potential to compliment other methods (e.g. structured interviews), as part of a values-based recruitment agenda. Methods including personal statements, references and unstructured/'traditional' interviews were identified as inappropriate for values-based recruitment. Practical implications are discussed in the context of values-based recruitment in the healthcare context. Theoretical implications of our findings imply that prosocial implicit trait policies, which could be measured by selection tools such as SJTs and MMIs, may be linked to individuals' values via the behaviours individuals consider to be effective in given situations. Further research is required to state this conclusively however, and methods for values-based recruitment represent an exciting and relatively unchartered territory for further research.

  12. Attitudes toward elective abortion: preliminary evidence of validity for the Personal Beliefs Scale.

    PubMed

    Embree, R A

    1998-06-01

    On the Personal Beliefs Scale of Embree and Embree item ratings obtained from 100 Midwestern undergraduates were used to classify participants into neutral, other, or second-order psychosomaticism mind-body belief types. Responses to a hypothetical abnormal pregnancy were used to measure attitude toward abortion (prochoice vs antichoice), meaning of abortion (not murder vs murder), and empathy for the unborn(low, moderate, or high). Values of chi 2 were statistically significant for students classified by mind-body belief type versus attitude toward abortion, and the meaning of abortion, but not for empathy for the unborn.

  13. Development and Preliminary Application of Multi-channel Agricultural Science and Technology Consulting Service U Disk

    NASA Astrophysics Data System (ADS)

    Yu, W. S.; Luo, C. S.; Wei, Q. F.; Zheng, Y. M.; Cao, C. Z.

    2017-12-01

    To deal with the “last kilometer” problem during the agricultural science and technology information service, the USB flash disk “Zixuntong”, which integrated five major consulting channels, i.e., telephone consultation, mutual video, message consultation, online customer service and QQ group was developed on the bases of capital experts and date resources. Since the products have the computer and telephone USB interface and are combined with localized information resources, users can obtain useful information on any terminal without the restriction of network. Meanwhile, the cartoon appearance make it friendly and attractive to people. The USB flash disk was used to provide agricultural expert consulting services and obtained a good preliminary application achievement. Finally, we concluded the creative application of USB flash disk in agricultural consulting services and prospected the future development direction of agricultural mobile consultation.

  14. Promoting evidence-based practice in pharmacies.

    PubMed

    Toklu, Hale Zerrin

    2015-01-01

    Evidence-based medicine aims to optimize decision-making by using evidence from well-designed and conducted research. The concept of reliable evidence is essential, since the number of electronic information resources is increasing in parallel to the increasing number and type of drugs on the market. The decision-making process is a complex and requires an extensive evaluation as well as the interpretation of the data obtained. Different sources provide different levels of evidence for decision-making. Not all the data have the same value as the evidence. Rational use of medicine requires that the patients receive "medicines appropriate to their clinical needs, in doses that meet their own individual requirements, for an adequate period of time, and at the lowest cost to them and their community." Pharmacists have a crucial role in the health system to maintain the rational use of medicine and provide pharmaceutical care to patients, because they are the drug experts who are academically trained for this purpose. The rational use of the pharmacist's workforce will improve the outcome of pharmacotherapy as well as decreasing the global health costs.

  15. Hydrothermal Liquefaction Treatment Preliminary Hazard Analysis Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lowry, Peter P.; Wagner, Katie A.

    A preliminary hazard assessment was completed during February 2015 to evaluate the conceptual design of the modular hydrothermal liquefaction treatment system. The hazard assessment was performed in 2 stages. An initial assessment utilizing Hazard Identification and Preliminary Hazards Analysis (PHA) techniques identified areas with significant or unique hazards (process safety-related hazards) that fall outside of the normal operating envelope of PNNL and warranted additional analysis. The subsequent assessment was based on a qualitative What-If analysis. This analysis was augmented, as necessary, by additional quantitative analysis for scenarios involving a release of hazardous material or energy with the potential for affectingmore » the public.« less

  16. Nursing and midwifery use, perceptions and barriers to evidence-based practice: a cross-sectional survey.

    PubMed

    Fry, Margaret; Attawet, Jutharat

    2018-03-01

    The study aimed to explore how nurses and midwives obtain, use and embed evidence in everyday practice. The study design was cross-sectional survey method. The setting was one local health district in metropolitan Sydney, Australia. All nurses and midwives working within the local health district, with access to an email account, were invited to participate in the study. An online survey questionnaire was distributed to explore how evidence is obtained, used and embedded within the clinical setting. The data were analysed using descriptive statistics (frequency and percentages). Pearson's Chi-square tests were used for comparison between groups. There were 204 survey respondents. The findings identified that the majority (n = 157; 76.96%) of respondents obtained evidence primarily from clinical practice guidelines. The majority (n = 149; 73.04%) of respondents reportedly searched databases and used evidence related to general clinical practice. There was a statistical difference (χ = 17.069; df = 8; P = 0.029) when comparing leadership positions and other registered practitioner groups in the frequency of searching for evidence. Most respondents (n = 138; 67.65%) were confident in their ability to change practice on the basis of available evidence. Thematic analysis identified four barriers to sustaining evidence-based practice, which included: the need for time; the need for organizational and management support; the need for educational opportunities and challenges to accessing evidence. The study provided an understanding of how nurses and midwives obtain, use and embed evidence into everyday practice. More importantly, the role of leadership is significant to support a process of knowledge generation, research translation and the implementation of evidence into clinical settings.

  17. 32 CFR 644.392 - Air Force-preliminary report of excess.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Air Force-preliminary report of excess. 644.392... PROPERTY REAL ESTATE HANDBOOK Disposal Predisposal Action § 644.392 Air Force—preliminary report of excess... Force screens its own properties for other defense requirements and clears the disposal with DOD and the...

  18. 76 FR 52945 - Chlorpyrifos Registration Review; Preliminary Human Health Risk Assessment; Extension of Comment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-24

    ... Review; Preliminary Human Health Risk Assessment; Extension of Comment Period AGENCY: Environmental... chlorpyrifos registration review; preliminary human health risk assessment. This document extends the comment... review, preliminary human health risk assessment, established in the Federal Register of Wednesday, July...

  19. Environment effects from SRB exhaust effluents: Technique development and preliminary assessment

    NASA Technical Reports Server (NTRS)

    Goldford, A. I.; Adelfang, S. I.; Hickey, J. S.; Smith, S. R.; Welty, R. P.; White, G. L.

    1977-01-01

    Techniques to determine the environmental effects from the space shuttle SRB (Solid Rocket Booster) exhaust effluents are used to perform a preliminary climatological assessment. The exhaust effluent chemistry study was performed and the exhaust effluent species were determined. A reasonable exhaust particle size distribution is constructed for use in nozzle analyses and for the deposition model. The preliminary assessment is used to identify problems that are associated with the full-scale assessment; therefore, these preliminary air quality results are used with caution in drawing conclusion regarding the environmental effects of the space shuttle exhaust effluents.

  20. Evidence mapping: illustrating an emerging methodology to improve evidence-based practice in youth mental health.

    PubMed

    Hetrick, Sarah E; Parker, Alexandra G; Callahan, Patrick; Purcell, Rosemary

    2010-12-01

    Within the field of evidence-based practice, a process termed 'evidence mapping' is emerging as a less exhaustive yet systematic and replicable methodology that allows an understanding of the extent and distribution of evidence in a broad clinical area, highlighting both what is known and where gaps in evidence exist. This article describes the general principles of mapping methodology by using illustrations derived from our experience conducting an evidence map of interventions for youth mental-health disorders. Evidence maps are based on an explicit research question relating to the field of enquiry, which may vary in depth, but should be informed by end-users. The research question then drives the search for, and collection of, appropriate studies utilizing explicit and reproducible methods at each stage. This includes clear definition of components of the research question, development of a thorough and reproducible search strategy, development of explicit inclusion and exclusion criteria, and transparent decisions about the level of information to be obtained from each study. Evidence mapping is emerging as a rigorous methodology for gathering and disseminating up-to-date information to end-users. Thoughtful planning and assessment of available resources (e.g. staff, time, budget) are required by those applying this methodology to their particular field of clinical enquiry given the potential scope of the work. The needs of the end-user need to be balanced with available resources. Information derived needs to be effectively communicated, with the uptake of that evidence into clinical practice the ultimate aim. © 2010 The Authors. Journal compilation © 2010 Blackwell Publishing Ltd.

  1. From randomized controlled trials to evidence grading schemes: current state of evidence-based practice in social sciences.

    PubMed

    Boruch, Robert; Rui, Ning

    2008-11-01

    With the advance of web search and navigation technology, enormous amount of information, non-information, and misinformation may be obtained in milliseconds in response to questions about 'what works' in social sciences. Today, policy makers in non-medical public service arenas are under increasing pressure to make sound decisions based on scientific evidence. Some of these decisions are a matter of legal requirement. This paper shows how such movements are closely aligned with the evolution of organizations that develop and apply evidence standards and evidence grading schemes within the social science communities. The current state of evidence-based practice in social sciences is examined by reviewing the latest development of randomized trials and evidence grading schemes in the fields of education, criminal justice, and social welfare. Studies conducted under the auspices of the Campbell Collaboration and What Works Clearinghouse are used to illustrate ingredients of evidence grading schemes, graphic display of results of systematic reviews, and discrepancies of evidence derived from randomized trials and non-experimental trials. Furthermore, it is argued that the use of evidence on 'what works' depends on the potential users' awareness, understanding of the evidence, as well as their capacity and willingness to use it. Awareness and understanding depends on the world wide web and its augmentations, while capacity and willingness depends more on incentives to use good evidence and on political and ethical values. Implications for the future development of evidence grading organizations are discussed. © 2008 Blackwell Publishing Asia Pty Ltd and Chinese Cochrane Center, West China Hospital of Sichuan University.

  2. A Preliminary Study of the Effectiveness of Different Recitation Teaching Methods

    NASA Astrophysics Data System (ADS)

    Endorf, Robert J.; Koenig, Kathleen M.; Braun, Gregory A.

    2006-02-01

    We present preliminary results from a comparative study of student understanding for students who attended recitation classes which used different teaching methods. Student volunteers from our introductory calculus-based physics course attended a special recitation class that was taught using one of four different teaching methods. A total of 272 students were divided into approximately equal groups for each method. Students in each class were taught the same topic, "Changes in energy and momentum," from Tutorials in Introductory Physics. The different teaching methods varied in the amount of student and teacher engagement. Student understanding was evaluated through pretests and posttests given at the recitation class. Our results demonstrate the importance of the instructor's role in teaching recitation classes. The most effective teaching method was for students working in cooperative learning groups with the instructors questioning the groups using Socratic dialogue. These results provide guidance and evidence for the teaching methods which should be emphasized in training future teachers and faculty members.

  3. Description and preliminary results of a 100 square meter rain gauge

    NASA Astrophysics Data System (ADS)

    Grimaldi, Salvatore; Petroselli, Andrea; Baldini, Luca; Gorgucci, Eugenio

    2018-01-01

    Rainfall is one of the most crucial processes in hydrology, and the direct and indirect rainfall measurement methods are constantly being updated and improved. The standard instrument used to measure rainfall rate and accumulation is the rain gauge, which provides direct observations. Though the small dimension of the orifice allows rain gauges to be installed anywhere, it also causes errors due to the splash and wind effects. To investigate the role of the orifice dimension, this study, for the first time, introduces and demonstrates an apparatus for observing rainfall called a giant-rain gauge that is characterised by a collecting surface of 100 m2. To discuss the new instrument and its technical details, a preliminary analysis of 26 rainfall events is provided. The results suggest that there are significant differences between the standard and proposed rain gauges. Specifically, major discrepancies are evident for low time aggregation scale (5, 10, and 15 min) and for high rainfall intensity values.

  4. 76 FR 61695 - Gulf of Mexico Regional Ecosystem Restoration Strategy (Preliminary)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    ... through Executive Order 13554 for the purpose of coordinating the long-term conservation and restoration... Ecosystem Restoration Strategy (Preliminary) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice... Ecosystem Restoration Strategy (Preliminary) for public review and feedback. The document is available at...

  5. A Cesium fountain frequency standard: Preliminary results

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Clairon, A.; Laurent, P.; Santarelli, G.

    1994-12-31

    Laser cooling of atoms has opened up new possibilities in the field of atomic frequency standards. A Cesium atomic fountain, first proposed by Zacharias in 1953, is now feasible: the atoms, first cooled by six laser beams, are launched upward using laser light, pass once through a microwave cavity, continue their ballistic flight and then fall through the same cavity. The long time between the two microwave interactions leads to a Ramsey resonance much narrower than in conventional Cs clocks using thermal atomic beams. The stability and accuracy of such a cesium fountain am very attractive. The use of diodemore » lasers to cool, launch and detect cesium atoms in a low cesium pressure cell allows the construction of a simple and reliable atomic fountain frequency standard. A fountain frequency standard is now in operation at LPTF. A Ramsey resonance as narrow as 0.8 Hz has been obtained. A few days of continuous operation are routinely obtained. In closed loop operation the fountain frequency standard is continuously monitored against a H maser allowing an evaluation of the accuracy of the device. The present short- term frequency stability is about 5.10{sup -13} {tau}{sup -1/2} limited only by the frequency noise of the microwave source. We intend to present a preliminary evaluation of this new standard with a discussion of the major systematic effects which determine the accuracy. The expected accuracy will be at 10-14 level. In addition, we will present a description of the whole design of the cesium fountain.« less

  6. 17 CFR 210.8-01 - Preliminary Notes to Article 8.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false Preliminary Notes to Article 8... CONSERVATION ACT OF 1975 Article 8 Financial Statements of Smaller Reporting Companies § 210.8-01 Preliminary Notes to Article 8. Sections 210.8-01 to 210.8-08 shall be applicable to financial statements filed for...

  7. Epigenetic perturbations in the pathogenesis of mustard toxicity; hypothesis and preliminary results

    PubMed Central

    Korkmaz, Ahmet; Yaren, Hakan; Kunak, Z. Ilker; Uysal, Bulent; Kurt, Bulent; Topal, Turgut; Kenar, Levent; Ucar, Ergun; Oter, Sukru

    2008-01-01

    Among the most readily available chemical warfare agents, sulfur mustard (SM), also known as mustard gas, has been the most widely used chemical weapon. SM causes debilitating effects that can leave an exposed individual incapacitated for days to months; therefore delayed SM toxicity is of much greater importance than its ability to cause lethality. Although not fully understood, acute toxicity of SM is related to reactive oxygen and nitrogen species, oxidative stress, DNA damage, poly(ADP-ribose) polymerase (PARP) activation and energy depletion within the affected cell. Therefore several antioxidants and PARP inhibitors show beneficial effects against acute SM toxicity. The delayed toxicity of SM however, currently has no clear mechanistic explanation. One third of the 100,000 Iranian casualties are still suffering from the detrimental effects of SM in spite of the extensive treatment. We, therefore, made an attempt whether epigenetic aberrations may contribute to pathogenesis of mustard poisoning. Preliminary evidence reveals that mechlorethamine (a nitrogen mustard derivative) exposure may not only cause oxidative stress, DNA damage, but epigenetic perturbations as well. Epigenetic refers to the study of changes that influence the phenotype without causing alteration of the genotype. It involves changes in the properties of a cell that are inherited but do not involve a change in DNA sequence. It is now known that in addition to mutations, epimutations contribute to a variety of human diseases. Under light of preliminary results, the current hypothesis will focus on epigenetic regulations to clarify mustard toxicity and the use of drugs to correct possible epigenetic defects. PMID:21218122

  8. Everyday episodic memory in amnestic mild cognitive impairment: a preliminary investigation.

    PubMed

    Irish, Muireann; Lawlor, Brian A; Coen, Robert F; O'Mara, Shane M

    2011-08-04

    Decline in episodic memory is one of the hallmark features of Alzheimer's disease (AD) and is also a defining feature of amnestic Mild Cognitive Impairment (MCI), which is posited as a potential prodrome of AD. While deficits in episodic memory are well documented in MCI, the nature of this impairment remains relatively under-researched, particularly for those domains with direct relevance and meaning for the patient's daily life. In order to fully explore the impact of disruption to the episodic memory system on everyday memory in MCI, we examined participants' episodic memory capacity using a battery of experimental tasks with real-world relevance. We investigated episodic acquisition and delayed recall (story-memory), associative memory (face-name pairings), spatial memory (route learning and recall), and memory for everyday mundane events in 16 amnestic MCI and 18 control participants. Furthermore, we followed MCI participants longitudinally to gain preliminary evidence regarding the possible predictive efficacy of these real-world episodic memory tasks for subsequent conversion to AD. The most discriminating tests at baseline were measures of acquisition, delayed recall, and associative memory, followed by everyday memory, and spatial memory tasks, with MCI patients scoring significantly lower than controls. At follow-up (mean time elapsed: 22.4 months), 6 MCI cases had progressed to clinically probable AD. Exploratory logistic regression analyses revealed that delayed associative memory performance at baseline was a potential predictor of subsequent conversion to AD. As a preliminary study, our findings suggest that simple associative memory paradigms with real-world relevance represent an important line of enquiry in future longitudinal studies charting MCI progression over time.

  9. Everyday episodic memory in amnestic mild cognitive impairment: a preliminary investigation

    PubMed Central

    2011-01-01

    Background Decline in episodic memory is one of the hallmark features of Alzheimer's disease (AD) and is also a defining feature of amnestic Mild Cognitive Impairment (MCI), which is posited as a potential prodrome of AD. While deficits in episodic memory are well documented in MCI, the nature of this impairment remains relatively under-researched, particularly for those domains with direct relevance and meaning for the patient's daily life. In order to fully explore the impact of disruption to the episodic memory system on everyday memory in MCI, we examined participants' episodic memory capacity using a battery of experimental tasks with real-world relevance. We investigated episodic acquisition and delayed recall (story-memory), associative memory (face-name pairings), spatial memory (route learning and recall), and memory for everyday mundane events in 16 amnestic MCI and 18 control participants. Furthermore, we followed MCI participants longitudinally to gain preliminary evidence regarding the possible predictive efficacy of these real-world episodic memory tasks for subsequent conversion to AD. Results The most discriminating tests at baseline were measures of acquisition, delayed recall, and associative memory, followed by everyday memory, and spatial memory tasks, with MCI patients scoring significantly lower than controls. At follow-up (mean time elapsed: 22.4 months), 6 MCI cases had progressed to clinically probable AD. Exploratory logistic regression analyses revealed that delayed associative memory performance at baseline was a potential predictor of subsequent conversion to AD. Conclusions As a preliminary study, our findings suggest that simple associative memory paradigms with real-world relevance represent an important line of enquiry in future longitudinal studies charting MCI progression over time. PMID:21816065

  10. 78 FR 28192 - Polyethylene Retail Carrier Bags From Thailand: Preliminary Results of Antidumping Duty...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ... Bags From Thailand: Preliminary Results of Antidumping Duty Administrative Review; 2011-2012 AGENCY... Import Administration, ``Decision Memorandum for Preliminary Results of the 2011/12 Antidumping Duty... (August 12, 2010) (Section 129 Determination). Preliminary Results of Review As a result of our review, we...

  11. Characterization of Bond Strength of U-Mo Fuel Plates Using the Laser Shockwave Technique: Capabilities and Preliminary Results

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    J. A. Smith; D. L. Cottle; B. H. Rabin

    2013-09-01

    This report summarizes work conducted to-date on the implementation of new laser-based capabilities for characterization of bond strength in nuclear fuel plates, and presents preliminary results obtained from fresh fuel studies on as-fabricated monolithic fuel consisting of uranium-10 wt.% molybdenum alloys clad in 6061 aluminum by hot isostatic pressing. Characterization involves application of two complementary experimental methods, laser-shock testing and laser-ultrasonic imaging, collectively referred to as the Laser Shockwave Technique (LST), that allows the integrity, physical properties and interfacial bond strength in fuel plates to be evaluated. Example characterization results are provided, including measurement of layer thicknesses, elastic properties ofmore » the constituents, and the location and nature of generated debonds (including kissing bonds). LST provides spatially localized, non-contacting measurements with minimum specimen preparation, and is ideally suited for applications involving radioactive materials, including irradiated materials. The theoretical principles and experimental approaches employed in characterizing nuclear fuel plates are described, and preliminary bond strength measurement results are discussed, with emphasis on demonstrating the capabilities and limitations of these methods. These preliminary results demonstrate the ability to distinguish bond strength variations between different fuel plates. Although additional development work is necessary to validate and qualify the test methods, these results suggest LST is viable as a method to meet fuel qualification requirements to demonstrate acceptable bonding integrity.« less

  12. Preliminary evaluation of several nondestructive-evaluation techniques for silicon nitride gas-turbine rotors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kupperman, D. S.; Sciammarella, C.; Lapinski, N. P.

    1978-01-01

    Several nondestructive-evaluation (NDE) techniques have been examined to establish their effectiveness for detecting critically sized flaws in silicon nitride gas-turbine rotors. Preliminary results have been obtained for holographic interferometry, acoustic microscopy, dye-enhanced radiography, acoustic emission, and acoustic-impact testing techniques. This report discusses the relative effectiveness of these techniques in terms of their applicability to the rotor geometry and ability to detect critically sized flaws. Where feasible, flaw indications were verified by alternative NDE techniques or destructive examination. This study has indicated that, since the various techniques have different advantages, ultimately a reliable interrogation of ceramic rotors may require the applicationmore » of several NDE methods.« less

  13. Space solar power. Description of concept, results of preliminary studies, requirements for evaluation

    NASA Technical Reports Server (NTRS)

    1977-01-01

    The nation is actively pursuing alternate sources of energy because of the problems or concerns related to obtaining required energy for the future from oil, gas, nuclear, and coal sources. Solar energy is an obvious candidate for consideration. Its use in the past has been limited by the relative cost of collecting and converting solar energy into electrical power. The increasing costs of other energy sources will make solar energy more attractive. During recent years a new concept for the collection of solar energy has been developed. This concept involves the location of solar power stations in space. The concept, results of preliminary studies, and requirements for space evaluation of such a project are discussed.

  14. 17 CFR 210.8-01 - Preliminary Notes to Article 8.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Preliminary Notes to Article 8... ADVISERS ACT OF 1940, AND ENERGY POLICY AND CONSERVATION ACT OF 1975 Article 8 Financial Statements of Smaller Reporting Companies § 210.8-01 Preliminary Notes to Article 8. Sections 210.8-01 to 210.8-08 shall...

  15. 17 CFR 210.8-01 - Preliminary Notes to Article 8.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Preliminary Notes to Article 8... ADVISERS ACT OF 1940, AND ENERGY POLICY AND CONSERVATION ACT OF 1975 Article 8 Financial Statements of Smaller Reporting Companies § 210.8-01 Preliminary Notes to Article 8. Sections 210.8-01 to 210.8-08 shall...

  16. Preliminary evidence for good psychometric properties of the Norwegian version of the Brief Problems Monitor (BPM).

    PubMed

    Richter, Jörg

    2015-04-01

    Methods to assess intervention progress and outcome for frequent use are needed. To provide preliminary information about psychometric properties for the Norwegian version of the Brief Problems Monitor. Cronbach's alpha scores and intra-class correlation coefficients as indicators for internal consistency (reliability) and Pearson correlation coefficients between corresponding subscales of the long and short ASEBA form versions as well as multiple regression coefficients to explore the predictive power of the reduced item-set related to the corresponding scale-scores of the long version were calculated in large, representative data sets of Norwegian children and adolescents. Cronbach's alpha scores of the Norwegian version of the BPM subscales varied between 0.67 (attention BPM-youth) and 0.88 (attention BPM-teacher) and between 0.90 (BPM-youth) and 0.96 (BPM-teacher) for its total problem score. Corresponding subscales from the long versions and the BPM as well as the total problems scores were closely correlated with coefficients of high effect size (all r > 0.80). The variance of the items of the BPM explained about three-quarters or more of the variance in the corresponding subscales of the long version. The Norwegian BPM has good psychometric properties in terms of 1) being acceptable to good internal consistency and in terms of 2) regression coefficients of high effect size from the BPM items to the problem-scale scores of the long versions as validity indicators. Its use in clinical practice and research can be recommended.

  17. A Preliminary Analysis of the Costs and Benefits of Older Age Accessions.

    DTIC Science & Technology

    1984-03-01

    8217AD-A143 160 A PRELIMINARY ANALYSIS OF THE COSTS AND BENEFITS OF I/ OLDER AGE ACCESSIONS(U) NAVAL POSTGRADUATE SCHOOL N A MONTEREY CA S D BARCLAY MAR...ELECTE JUL 1884d THESIS A PRELIMINARY ANALYSIS CF THE COSTS AND BENEFITS OF OLDER AGE ACCESSIONS CL by Susan D. Barclay March 1984 Thesis Advisor...for public release; distribution unlimited. A Preliminary Analysis of the Costs and Benefits of Older Age Accessions by Susan D. Barclay Lieutenant

  18. Altering micro-environments to change population health behaviour: towards an evidence base for choice architecture interventions.

    PubMed

    Hollands, Gareth J; Shemilt, Ian; Marteau, Theresa M; Jebb, Susan A; Kelly, Michael P; Nakamura, Ryota; Suhrcke, Marc; Ogilvie, David

    2013-12-21

    The idea that behaviour can be influenced at population level by altering the environments within which people make choices (choice architecture) has gained traction in policy circles. However, empirical evidence to support this idea is limited, especially its application to changing health behaviour. We propose an evidence-based definition and typology of choice architecture interventions that have been implemented within small-scale micro-environments and evaluated for their effects on four key sets of health behaviours: diet, physical activity, alcohol and tobacco use. We argue that the limitations of the evidence base are due not simply to an absence of evidence, but also to a prior lack of definitional and conceptual clarity concerning applications of choice architecture to public health intervention. This has hampered the potential for systematic assessment of existing evidence. By seeking to address this issue, we demonstrate how our definition and typology have enabled systematic identification and preliminary mapping of a large body of available evidence for the effects of choice architecture interventions. We discuss key implications for further primary research, evidence synthesis and conceptual development to support the design and evaluation of such interventions. This conceptual groundwork provides a foundation for future research to investigate the effectiveness of choice architecture interventions within micro-environments for changing health behaviour. The approach we used may also serve as a template for mapping other under-explored fields of enquiry.

  19. Preliminary evidence of early bone resorption in a sheep model of acute burn injury: an observational study.

    PubMed

    Klein, Gordon L; Xie, Yixia; Qin, Yi-Xian; Lin, Liangjun; Hu, Minyi; Enkhbaatar, Perenlei; Bonewald, Lynda F

    2014-03-01

    Treatment with bisphosphonates within the first 10 days of severe burn injury completely prevents bone loss. We therefore postulated that bone resorption occurs early post burn and is the primary explanation for acute bone loss in these patients. Our objective was to assess bone for histological and biomechanical evidence of early resorption post burn. We designed a randomized controlled study utilizing a sheep model of burn injury. Three sheep received a 40 % total body surface area burn under isoflurane anesthesia, and three other sheep received cotton-smoke inhalation and served as control. Burned sheep were killed 5 days post procedure and controls were killed 2 days post procedure. Backscatter scanning electron microscopy was performed on iliac crests obtained immediately postmortem along with quantitative histomorphometry and compression testing to determine bone strength (Young's modulus). Blood ionized Ca was also determined in the first 24 h post procedure as was urinary CTx. Three of three sheep killed at 5 days had evidence of scalloping of the bone surface, an effect of bone resorption, whereas none of the three sheep killed at 2 days post procedure had scalloping. One of the three burned sheep killed at 5 days showed quantitative doubling of the eroded surface and halving of the bone volume compared to sham controls. Mean values of Young's modulus were approximately one third lower in the burned sheep killed at 5 days compared to controls, p = 0.08 by unpaired t test, suggesting weaker bone. These data suggest early post-burn bone resorption. Urine CTx normalized to creatinine did not differ between groups at 24 h post procedure because the large amounts of fluids received by the burned sheep may have diluted urine creatinine and CTx and because the urine volume produced by the burned sheep was threefold that of the controls. We calculated 24 h urinary CTx excretion, and with this calculation CTx excretion/24 h in the burned sheep was

  20. A Pilot Study of Adjunctive Family Psychoeducation in Adolescent Major Depression: Feasibility and Treatment Effect

    ERIC Educational Resources Information Center

    Sanford, Mark; Boyle, Michael; McCleary, Lynn; Miller, Jennifer; Steele, Margaret; Duku, Eric; Offord, David

    2006-01-01

    Objective: To obtain preliminary evidence of the feasibility and effectiveness of adjunctive family psychoeducation in adolescent major depressive disorder. Method: Participants were from outpatient clinics in Hamilton and London, Ontario. Over 24 months, 41 adolescents ages 13 through 18 years meeting major depressive disorder criteria were…

  1. Sex-Specific Associations between Umbilical Cord Blood Testosterone Levels and Language Delay in Early Childhood

    ERIC Educational Resources Information Center

    Whitehouse, Andrew J. O.; Mattes, Eugen; Maybery, Murray T.; Sawyer, Michael G.; Jacoby, Peter; Keelan, Jeffrey A.; Hickey, Martha

    2012-01-01

    Background: Preliminary evidence suggests that prenatal testosterone exposure may be associated with language delay. However, no study has examined a large sample of children at multiple time-points. Methods: Umbilical cord blood samples were obtained at 861 births and analysed for bioavailable testosterone (BioT) concentrations. When…

  2. Engineering evidence for carbon monoxide toxicity cases.

    PubMed

    Galatsis, Kosmas

    2016-07-01

    Unintentional carbon monoxide poisonings and fatalities lead to many toxicity cases. Given the unusual physical properties of carbon monoxide-in that the gas is odorless and invisible-unorganized and erroneous methods in obtaining engineering evidence as required during the discovery process often occurs. Such evidence gathering spans domains that include building construction, appliance installation, industrial hygiene, mechanical engineering, combustion and physics. In this paper, we attempt to place a systematic framework that is relevant to key aspects in engineering evidence gathering for unintentional carbon monoxide poisoning cases. Such a framework aims to increase awareness of this process and relevant issues to help guide legal counsel and expert witnesses. © The Author(s) 2015.

  3. Obtaining antibiotics online from within the UK: a cross-sectional study

    PubMed Central

    Boyd, Sara Elizabeth; Moore, Luke Stephen Prockter; Gilchrist, Mark; Costelloe, Ceire; Castro-Sánchez, Enrique; Franklin, Bryony Dean; Holmes, Alison Helen

    2017-01-01

    Background: Improved antibiotic stewardship (AS) and reduced prescribing in primary care, with a parallel increase in personal internet use, could lead citizens to obtain antibiotics from alternative sources online. Objectives: A cross-sectional analysis was performed to: (i) determine the quality and legality of online pharmacies selling antibiotics to the UK public; (ii) describe processes for obtaining antibiotics online from within the UK; and (iii) identify resulting AS and patient safety issues. Methods: Searches were conducted for ‘buy antibiotics online’ using Google and Yahoo. For each search engine, data from the first 10 web sites with unique URL addresses were reviewed. Analysis was conducted on evidence of appropriate pharmacy registration, prescription requirement, whether antibiotic choice was ‘prescriber-driven’ or ‘consumer-driven’, and whether specific information was required (allergies, comorbidities, pregnancy) or given (adverse effects) prior to purchase. Results: Twenty unique URL addresses were analysed in detail. Online pharmacies evidencing their location in the UK (n = 5; 25%) required a prescription before antibiotic purchase, and were appropriately registered. Online pharmacies unclear about the location they were operating from (n = 10; 50%) had variable prescription requirements, and no evidence of appropriate registration. Nine (45%) online pharmacies did not require a prescription prior to purchase. For 16 (80%) online pharmacies, decisions were initially consumer-driven for antibiotic choice, dose and quantity. Conclusions: Wide variation exists among online pharmacies in relation to antibiotic practices, highlighting considerable patient safety and AS issues. Improved education, legislation, regulation and new best practice stewardship guidelines are urgently needed for online antibiotic suppliers. PMID:28333179

  4. 24 CFR 570.461 - Post-preliminary approval requirements; lead-based paint.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... requirements; lead-based paint. 570.461 Section 570.461 Housing and Urban Development Regulations Relating to... GRANTS Urban Development Action Grants § 570.461 Post-preliminary approval requirements; lead-based paint. The recipient may receive preliminary approval prior to the accomplishment of lead-based paint...

  5. 24 CFR 570.461 - Post-preliminary approval requirements; lead-based paint.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... requirements; lead-based paint. 570.461 Section 570.461 Housing and Urban Development Regulations Relating to... GRANTS Urban Development Action Grants § 570.461 Post-preliminary approval requirements; lead-based paint. The recipient may receive preliminary approval prior to the accomplishment of lead-based paint...

  6. 24 CFR 570.461 - Post-preliminary approval requirements; lead-based paint.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... requirements; lead-based paint. 570.461 Section 570.461 Housing and Urban Development Regulations Relating to... GRANTS Urban Development Action Grants § 570.461 Post-preliminary approval requirements; lead-based paint. The recipient may receive preliminary approval prior to the accomplishment of lead-based paint...

  7. 24 CFR 570.461 - Post-preliminary approval requirements; lead-based paint.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... requirements; lead-based paint. 570.461 Section 570.461 Housing and Urban Development Regulations Relating to... GRANTS Urban Development Action Grants § 570.461 Post-preliminary approval requirements; lead-based paint. The recipient may receive preliminary approval prior to the accomplishment of lead-based paint...

  8. 24 CFR 570.461 - Post-preliminary approval requirements; lead-based paint.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... requirements; lead-based paint. 570.461 Section 570.461 Housing and Urban Development Regulations Relating to... GRANTS Urban Development Action Grants § 570.461 Post-preliminary approval requirements; lead-based paint. The recipient may receive preliminary approval prior to the accomplishment of lead-based paint...

  9. Levels of Evidence: Integrative Therapies Human Studies (PDQ®)—Health Professional Version

    Cancer.gov

    Levels of Evidence for Integrative, Alternative, and Complementary Therapies is about how to weigh the strength of the evidence obtained in cited research studies. Get detailed information this formal ranking system in this summary for clinicians.

  10. A Preliminary Study of a Solar-Probe Mission

    NASA Technical Reports Server (NTRS)

    Dugan, Duane W.

    1961-01-01

    A preliminary study is made of some problems associated with the sending of an instrumented probe close to the Sun for the purpose of gathering and telemetering back to Earth information concerning solar phenomena and circumsolar space. The problems considered are primarily those relating to heating and to launch requirements. A nonanalytic discussion of the communications problem of a solar-probe mission is presented to obtain order-of-magnitude estimates of the output and weight of an auxiliary power supply which might be required. From the study it is believed that approaches to the Sun as close as about 4 or 5 million miles do not present insuperable difficulties insofar as heating and communications are concerned. Guidance requirements, in general, do not appear to be stringent. However, in terms of current experience, velocity requirements may be large. It is found, for example, that to achieve perihelion distances between the orbit of Mercury and the visible disc of the Sun, total burnout velocities ranging between 50,000 and 100,000 feet per second are required.

  11. [New visual field testing possibilities (a preliminary report)].

    PubMed

    Erichev, V P; Ermolaev, A P; Antonov, A A; Grigoryan, G L; Kosova, D V

    2018-01-01

    There are currently no portable mobile perimeters that allow visual field testing outside ophthalmologist's examination rooms. To develop a mobile perimetry technique based on use of a virtual reality headset (VR). The study involved 26 patients (30 eyes) with II-III stage primary open-angle glaucoma (POAG) with compensated IOP. Perimetry was performed for each patient twice - on Humphrey analyzer (test 30-2, 76 points) and employing similar strategy on a perimeter integrated into VR headset (Total Vision, Russia). Visual field testing was performed with an interval from 1 hour to 3 days. The results were comparatively analyzed. Patients tolerated the examination well. Comparative analysis of preliminary perimetry results obtained with both methods showed high degree of identity, so the results were concluded to be comparable. By visually isolating the wearer, VR headset achieves elimination of distractions and stable light conditions for visual field testing. The headset-perimeter is compact, mobile, easily transportable, can be used in the work of visiting medical teams and for examination at home.

  12. Brain Plasticity following Intensive Bimanual Therapy in Children with Hemiparesis: Preliminary Evidence

    PubMed Central

    Weinstein, Maya; Myers, Vicki; Green, Dido; Schertz, Mitchell; Shiran, Shelly I.; Geva, Ronny; Artzi, Moran; Gordon, Andrew M.; Fattal-Valevski, Aviva; Ben Bashat, Dafna

    2015-01-01

    Neuroplasticity studies examining children with hemiparesis (CH) have focused predominantly on unilateral interventions. CH also have bimanual coordination impairments with bimanual interventions showing benefits. We explored neuroplasticity following hand-arm bimanual intensive therapy (HABIT) of 60 hours in twelve CH (6 females, mean age 11 ± 3.6 y). Serial behavioral evaluations and MR imaging including diffusion tensor (DTI) and functional (fMRI) imaging were performed before, immediately after, and at 6-week follow-up. Manual skills were assessed repeatedly with the Assisting Hand Assessment, Children's Hand Experience Questionnaire, and Jebsen-Taylor Test of Hand Function. Beta values, indicating the level of activation, and lateralization index (LI), indicating the pattern of brain activation, were computed from fMRI. White matter integrity of major fibers was assessed using DTI. 11/12 children showed improvement after intervention in at least one measure, with 8/12 improving on two or more tests. Changes were retained in 6/8 children at follow-up. Beta activation in the affected hemisphere increased at follow-up, and LI increased both after intervention and at follow-up. Correlations between LI and motor function emerged after intervention. Increased white matter integrity was detected in the corpus callosum and corticospinal tract after intervention in about half of the participants. Results provide first evidence for neuroplasticity changes following bimanual intervention in CH. PMID:26640717

  13. Epidemiological evidence of carcinogenicity of chlorinated organics in drinking water.

    PubMed

    Cantor, K P

    1982-12-01

    Concern has recently been voiced over possible chronic toxicity associated with chlorination of public drinking water supplies in the United States. This paper reviews the available evidence and the studies underway to further evaluate hypothesized associations between cancer risk and byproducts of chlorination. Preliminary data from measures of halogenated volatiles and personal exposure histories from respondents in a large epidemiologic study of bladder cancer are presented. These data support the use in epidemiologic studies of categorical measures of exposure and suggest that results from completed case-control studies, based on death certificates, may have underestimated the true risk of exposure to chlorination by-products. The current generation of studies which use a case-control interview design offer many advantages over earlier efforts to evaluate this issue.

  14. Evidence-Based Reading Instruction for Individuals with Autism Spectrum Disorders

    PubMed Central

    Whalon, Kelly J.; Al Otaiba, Stephanie; Delano, Monica E.

    2009-01-01

    Legislation mandates that all children, including children with autism spectrum disorders (ASD) be taught to read in ways that are consistent with reading research, and target the five components of evidence-based reading instruction: phonemic awareness, phonics, reading fluency, vocabulary and comprehension strategies. The purpose of this review is to synthesize the literature on reading instruction for children with ASD that encompasses one or more of the five components of reading. The review yielded 11 studies with 61 participants ages 4 to 17. Results indicate that children with ASD can benefit from reading instruction consistent with reading research. Research in this area is still preliminary, and more research is needed to guide practice. Possible directions for future research are provided. PMID:20161582

  15. Characterization of rhenium compounds obtained by electrochemical synthesis after aging process

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Vargas-Uscategui, Alejandro, E-mail: avargasuscat@ing.uchile.cl; Mosquera, Edgar; López-Encarnación, Juan M.

    2014-12-15

    The proper identification of the molecular nature of the aged rhenium compound obtained by means of electrodeposition from an alkaline aqueous electrolyte was determined. Chemical, structural and vibrational experimental characterization of the aged Re compound showed agreement with quantum-computations, thereby allowing the unambiguous identification of the Re compound as H(ReO{sub 4})H{sub 2}O. - Graphical abstract: Rhenium oxides were electrodeposited on a copper surface and after environmental aging was formed the H(ReO{sub 4})H{sub 2}O compound. The characterization of the synthesized material was made through the comparison of experimental evidence with quantum mechanical computations carried out by means of density functional theorymore » (DFT). - Highlights: • Aged rhenium compound obtained by means of electrodeposition was studied. • The study was made by combining experimental and DFT-computational information. • The aged electrodeposited material is consistent with the H(ReO{sub 4})H{sub 2}O compound.« less

  16. Preliminary design report for OTEC stationkeeping subsystems (SKSS)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1979-12-12

    Lockheed Ocean Systems with IMODCO prepared these preliminary designs for OTEC Stationkeeping Subsystems (SKSS) under contract to NOAA in support of the Department of Energy OTEC program. The results of Tasks III, V, and VI are presented in this design report. The report consists of five sections: introduction, preliminary designs for the multiple anchor leg (MAL) and tension anchor leg (TAL), costs and schedule, and conclusions. Extensive appendixes provide detailed descriptions of design methodology and include backup calculations and data to support the results presented. The objective of this effort is to complete the preliminary designs for the barge-MAL andmore » Spar-TAL SKSS. A set of drawings is provided for each which show arrangements, configuration, component details, engineering description, and deployment plan. Loads analysis, performance assessment, and sensitivity to requirements are presented, together with the methodology employed to analyze the systems and to derive the results presented. Life cycle costs and schedule are prepared and compared on a common basis. Finally, recommendations for the Commercial Plant SKSS are presented for both platform types.« less

  17. Screening of Anti-Malarial Activity of Different Extracts Obtained from Three Species of Scrophularia Growing in Iran

    PubMed Central

    Heshmati Afshar, Fariba; Delazar, Abbas; Asnaashari, Solmaz; Vaez, Haleh; Zolali, Elmira; Asgharian, Parina

    2018-01-01

    Scrophularia genus belonging to the family of Scrophulariaceae, is a medicinal plant widely distributed in Iran. In the present study, the anti-malarial activity of different extracts of three Iranian endemic species of Scrophularia including S. frigida, S. subaphylla and S. atropatana, was screened by an in-vitro preliminary assay. The plant materials were extracted successively with n-hexane, dichloromethane (DCM), and methanol (MeOH) at room temperature by soxhlet extractor. In order to assess anti-malarial activity of obtained extracts, cell free β-hematin formation assay was applied. Amongst the extracts, DCM extract of S. frigida exhibited remarkable anti-malarial activity with IC50 value of 0.67 ± 0.11 mg/mL. In contrast, MeOH and n-hexane extracts of all plants illustrated insignificant or moderate activity in this assay. Furthermore, preliminary phytochemical analysis along with TLC and GC-MS analysis of potent extract (DCM extract of S. frigida) were performed for more clarification. These methods revealed that the notable anti-malarial activity might be due to the presence of active constituents like methoxylated flavonoids, methylated coumarins, and diterpenoids. From the nine extracts of different species of Scrophularia, DCM extract of S. frigida showed potent inhibitory activity on β-hematin formation assay. Hence, it seems that it is noteworthy to concentrate on purifying the active chemical constituents of DCM extract and determining the pure anti-malarial components. PMID:29881424

  18. Method for obtaining aerodynamic data on hypersonic configurations with scramjet exhaust flow simulation

    NASA Technical Reports Server (NTRS)

    Hartill, W. R.

    1977-01-01

    A hypersonic wind tunnel test method for obtaining credible aerodynamic data on a complete hypersonic vehicle (generic X-24c) with scramjet exhaust flow simulation is described. The general problems of simulating the scramjet exhaust as well as accounting for scramjet inlet flow and vehicle forces are analyzed, and candidate test methods are described and compared. The method selected as most useful makes use of a thrust-minus-drag flow-through balance with a completely metric model. Inlet flow is diverted by a fairing. The incremental effect of the fairing is determined in the testing of two reference models. The net thrust of the scramjet module is an input to be determined in large-scale module tests with scramjet combustion. Force accounting is described, and examples of force component levels are predicted. Compatibility of the test method with candidate wind tunnel facilities is described, and a preliminary model mechanical arrangement drawing is presented. The balance design and performance requirements are described in a detailed specification. Calibration procedures, model instrumentation, and a test plan for the model are outlined.

  19. 10 CFR 60.7 - License not required for certain preliminary activities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false License not required for certain preliminary activities. 60.7 Section 60.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.7 License not required for certain preliminary...

  20. 10 CFR 60.7 - License not required for certain preliminary activities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false License not required for certain preliminary activities. 60.7 Section 60.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.7 License not required for certain preliminary...

  1. [Is "evidence-based medicine" followed by "confidence-based medicine"?].

    PubMed

    Porzsolt, Franz; Fangerau, Heiner

    2010-08-01

    In an appeal concerning accusations of defamation, the England and Wales Court of Appeal Decisions determined that evidence-based statements are to be judged as opinions and not statements of fact. Since the authors consider it probable that this legal judgment will exert influence on physicians' decisions about the provision of health care services, they have compiled the implications of the judgment and discuss its consequences. The own analyses and considerations lead to the conclusion that confidence-based medicine follows evidence-based medicine. This extension is necessary because evidence-based medicine has not been able to generate the required trust. Therefore, it will be demanded to underpin the existing concept with additional data. These data will be necessary because it is no longer sufficient to convince scientists with data which are obtained under ideal conditions, but to convince critical members of society with additional data which have been obtained under everyday conditions.

  2. Understanding and practice of evidence based search strategy among postgraduate dental students: a preliminary study.

    PubMed

    Qureshi, Ambrina; Bokhari, Syed Akhtar Hussain; Pirvani, Madiha; Dawani, Narendar

    2015-06-01

    One of the core attributes of competent practice is the ability to locate and analyze high-quality evidence. Research on information seeking knowledge of dental graduates is scarce. The objective was to evaluate pertinent knowledge and skills on formulation of answerable questions and searching skills through the understanding and application of EBP. Participants' understanding and abilities to develop answerable questions in application of EBP were assessed through a quasi-experimental study design among freshly inducted postgraduate dental students at Dow University of Health Sciences. Pre and post workshop activity sessions were conducted and assessment was made through a tool that was an adaptation of the Fresno Test. The assessments performed were calculated for mean scores and standard deviations to draw descriptive results for the participants' understanding of the search items and clinical question formulation skills. Wilcoxon-signed rank test was performed to compare the pre and post workshop mean scores. Forty two participants (females = 20, males = 22) attended the workshop. Pre-workshop knowledge and understanding about the terminologies used in EBP was low among participants. Post-workshop performance of the participants to formulate a question, find evidence and search on PubMed was improved to a "Limited" level. The improvements were statistically significant but could not attain "Strong" and "Excellent" grades as far as the EBP skills were concerned. This study observed a potential to improve search skills of dental graduates after their training and exposure to search strategies available on databases. Copyright © 2015 Elsevier Inc. All rights reserved.

  3. 42 CFR 455.14 - Preliminary investigation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS PROGRAM INTEGRITY: MEDICAID Medicaid Agency Fraud Detection and Investigation Program § 455.14 Preliminary investigation. If the agency receives a complaint of Medicaid fraud...

  4. San Mateo Creek Basin Preliminary Assessment

    EPA Pesticide Factsheets

    The objective of this Preliminary Assessment is to evaluate the site using the Hazard Ranking System and the Superfund Chemical Data Matrix to determine if a threat to human health and the environment exists such that further action is warranted.

  5. ISSA/TSS power preliminary design

    NASA Technical Reports Server (NTRS)

    Main, John A.

    1996-01-01

    A projected power shortfall during the initial utilization flights of the International Space Station Alpha (ISSA) has prompted an inquiry into the use of the Tethered Satellite System (TSS) to provide station power. The preliminary design of the combined ISSA/TSS system is currently underway in the Preliminary Design Office at the Marshall Space Flight Center. This document focuses on the justification for using a tether system on space station, the physical principles behind such a system, and how it might be operated to best utilize its capabilities. The basic components of a simple DC generator are a magnet of some type and a conductive wire. Moving the wire through the magnetic field causes forces to be applied to the electric charges in the conductor, and thus current is induced to flow. This simple concept is the idea behind generating power with space-borne tether systems. The function of the magnet is performed by the earth's magnetic field, and orbiting a conductive tether about the earth effectively moves the tether through the field.

  6. Descent advisor preliminary field test

    NASA Technical Reports Server (NTRS)

    Green, Steven M.; Vivona, Robert A.; Sanford, Beverly

    1995-01-01

    A field test of the Descent Advisor (DA) automation tool was conducted at the Denver Air Route Traffic Control Center in September 1994. DA is being developed to assist Center controllers in the efficient management and control of arrival traffic. DA generates advisories, based on trajectory predictions, to achieve accurate meter-fix arrival times in a fuel efficient manner while assisting the controller with the prediction and resolution of potential conflicts. The test objectives were to evaluate the accuracy of DA trajectory predictions for conventional- and flight-management-system-equipped jet transports, to identify significant sources of trajectory prediction error, and to investigate procedural and training issues (both air and ground) associated with DA operations. Various commercial aircraft (97 flights total) and a Boeing 737-100 research aircraft participated in the test. Preliminary results from the primary test set of 24 commercial flights indicate a mean DA arrival time prediction error of 2.4 sec late with a standard deviation of 13.1 sec. This paper describes the field test and presents preliminary results for the commercial flights.

  7. Descent Advisor Preliminary Field Test

    NASA Technical Reports Server (NTRS)

    Green, Steven M.; Vivona, Robert A.; Sanford, Beverly

    1995-01-01

    A field test of the Descent Advisor (DA) automation tool was conducted at the Denver Air Route Traffic Control Center in September 1994. DA is being developed to assist Center controllers in the efficient management and control of arrival traffic. DA generates advisories, based on trajectory predictions, to achieve accurate meter-fix arrival times in a fuel efficient manner while assisting the controller with the prediction and resolution of potential conflicts. The test objectives were: (1) to evaluate the accuracy of DA trajectory predictions for conventional and flight-management system equipped jet transports, (2) to identify significant sources of trajectory prediction error, and (3) to investigate procedural and training issues (both air and ground) associated with DA operations. Various commercial aircraft (97 flights total) and a Boeing 737-100 research aircraft participated in the test. Preliminary results from the primary test set of 24 commercial flights indicate a mean DA arrival time prediction error of 2.4 seconds late with a standard deviation of 13.1 seconds. This paper describes the field test and presents preliminary results for the commercial flights.

  8. IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (ETBE) (Preliminary Assessment Materials)

    EPA Science Inventory

    In August 2013, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for ETBE to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in ...

  9. Spontaneous eye blink rate and dopamine synthesis capacity: preliminary evidence for an absence of positive correlation.

    PubMed

    Sescousse, Guillaume; Ligneul, Romain; van Holst, Ruth J; Janssen, Lieneke K; de Boer, Femke; Janssen, Marcel; Berry, Anne S; Jagust, William J; Cools, Roshan

    2018-05-01

    Dopamine is central to a number of cognitive functions and brain disorders. Given the cost of neurochemical imaging in humans, behavioural proxy measures of dopamine have gained in popularity in the past decade, such as spontaneous eye blink rate (sEBR). Increased sEBR is commonly associated with increased dopamine function based on pharmacological evidence and patient studies. Yet, this hypothesis has not been validated using in vivo measures of dopamine function in humans. To fill this gap, we measured sEBR and striatal dopamine synthesis capacity using [ 18 F]DOPA PET in 20 participants (nine healthy individuals and 11 pathological gamblers). Our results, based on frequentist and Bayesian statistics, as well as region-of-interest and voxel-wise analyses, argue against a positive relationship between sEBR and striatal dopamine synthesis capacity. They show that, if anything, the evidence is in favour of a negative relationship. These results, which complement findings from a recent study that failed to observe a relationship between sEBR and dopamine D2 receptor availability, suggest that caution and nuance are warranted when interpreting sEBR in terms of a proxy measure of striatal dopamine. © 2018 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

  10. IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (Etbe) ...

    EPA Pesticide Factsheets

    In August 2013, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for ETBE to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in comments on the following: Draft literature search strategies The approach for identifying studies The screening process for selecting pertinent studies The resulting list of pertinent studies Preliminary evidence tables The process for selecting studies to include in evidence tables The quality of the studies in the evidence tables The literature search strategy, which describes the processes for identifying scientific literature, contains the studies that EPA considered and selected to include in the evidence tables. The preliminary evidence tables and exposure-response arrays present the key study data in a standardized format. The evidence tables summarize the available critical scientific literature. The exposure-response figures provide a graphical representation of the responses at different levels of exposure for each study in the evidence table. The draft Toxicological Review of Ethyl Tertiary Butyl Ether provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to ethyl tertiary butyl ether.

  11. [Evaluation of preliminary grades and credits in nurse training programs].

    PubMed

    Darmann-Finck, Ingrid; Duveneck, Nicole

    2016-01-01

    In the federal state of Bremen preliminary grades were included to the extent of 25 % in written, oral and practical final grades during the time period 2009-2014. The evaluation focuses on the effects of preliminary grades on the scale of final grades and the performance of learners as well as on the assessment of the appropriateness of final grades. A mixed-methods design was employed that consisted of a quasi-experimental study comprising of surveys of students and teachers of comparative and model courses as well as a qualitative study using group discussions. The results confirm that preliminary grades lead to a minimal improvement of the final grades of some exclusively low-achieving students. The assessment of appropriateness hardly changed. From both learners' and teachers' point of view there is still great dissatisfaction concerning the practical final grades. With regard to learning habits an increased willingness to learn new skills on the one hand and a partly increased performance pressure on the other hand were demonstrated. On the basis of these research results, the authors recommend the regular introduction of preliminary marks into the nursing training. Copyright © 2016. Published by Elsevier GmbH.

  12. Renewable Energy Park - Preliminary Feasibility & Engineering Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ariwite, Roderick

    This "Renewable Energy Park - Preliminary Feasibility & Engineering Report" seeks to provide an overall assessment and review of renewable energy development opportunities on the Fallon Indian Reservation and Colony Lands.

  13. Naltrexone in organic bulimia: a preliminary report.

    PubMed

    Childs, A

    1987-01-01

    Multiple lines of experimental evidence point to the involvement of endogenous opiates in appetite regulation. Post brain injury patients often exhibit driven eating behaviour. Since this problem fails to respond to behaviour modification, appetite suppressants, lithium, or any other usual approach, the use of the oral narcotic antagonist, Naltrexone, was given to three such patients. Naltrexone binds multiple opiate receptor sites in the hypothalamus, including the kappa receptors which have been implicated in appetite regulation, the use of this narcotic antagonist in hypothalamic hyperphagia appears to be a rational approach to this intractable problem. In this open trial, lasting from 4 1/2 to 9 months, the minimal effective dose appeared to be in the range of 100 mg per day. No side-effects (for example elevations in liver enzymes) were noted. All of the patients had an improved sense of well-being and their behaviours were less difficult to manage when on the Naltrexone. The significance of this preliminary trial is that narcotic antagonists may have a role in the treatment of brain-injured patients with bulimia. Also, Naltrexone may be useful in treating other maladaptive behavioural consequences of head trauma such as stealing, manipulation, demandingness, and depression. Likewise, the effects on the deranged endocrine system, such as the hypogonadism, are significant and deserve further exploration.

  14. Factors influencing law enforcement decisions to adopt an evidence-based robbery prevention program.

    PubMed

    Cabell, A; Casteel, C; Chronister, T; Nocera, M; Vladutiu, C J; Peek-Asa, C

    2013-12-01

    Homicide is the leading cause of workplace death among small retail and service businesses in the United States. Evidence-based programs have been shown to reduce robbery and robbery-related crimes in small retail businesses; however, reaching small businesses with programs has been difficult. As small businesses typically have no corporate backing or trade affiliation, police departments have been identified as potential vehicles for program dissemination. A national sample of 300 law enforcement agencies was surveyed to identify facilitators and barriers to adoption and sustainability of an evidence-based program. The questionnaire was developed using behavioral theory concepts and administered via telephone. Preliminary findings suggest the primary facilitators to program adoption included organizational capacity factors such as staff buy-in, dedicated personnel and financial support. Competing responsibilities was the primary barrier identified by agencies. Agency size and program complexity were identified as potential predictors of program adoption. Identifying agency and program-specific characteristics that influence program adoption by law enforcement agencies will be valuable for marketing programs to agencies that have the infrastructure to support and sustain program dissemination. Understanding these factors will optimize the reach of evidence-based strategies to small businesses.

  15. Hierarchical Modeling and Robust Synthesis for the Preliminary Design of Large Scale Complex Systems

    NASA Technical Reports Server (NTRS)

    Koch, Patrick N.

    1997-01-01

    constructing partitioned response surfaces is developed to reduce the computational expense of experimentation for fitting models in a large number of factors. Noise modeling techniques are compared and recommendations are offered for the implementation of robust design when approximate models are sought. These techniques, approaches, and recommendations are incorporated within the method developed for hierarchical robust preliminary design exploration. This method as well as the associated approaches are illustrated through their application to the preliminary design of a commercial turbofan turbine propulsion system. The case study is developed in collaboration with Allison Engine Company, Rolls Royce Aerospace, and is based on the Allison AE3007 existing engine designed for midsize commercial, regional business jets. For this case study, the turbofan system-level problem is partitioned into engine cycle design and configuration design and a compressor modules integrated for more detailed subsystem-level design exploration, improving system evaluation. The fan and low pressure turbine subsystems are also modeled, but in less detail. Given the defined partitioning, these subproblems are investigated independently and concurrently, and response surface models are constructed to approximate the responses of each. These response models are then incorporated within a commercial turbofan hierarchical compromise decision support problem formulation. Five design scenarios are investigated, and robust solutions are identified. The method and solutions identified are verified by comparison with the AE3007 engine. The solutions obtained are similar to the AE3007 cycle and configuration, but are better with respect to many of the requirements.

  16. 25 CFR 162.539 - Must I obtain a WEEL before obtaining a WSR lease?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... AND PERMITS Wind and Solar Resource Leases Wsr Leases § 162.539 Must I obtain a WEEL before obtaining... direct result of energy resource information gathered from a WEEL activity, obtaining a WEEL is not a...

  17. 25 CFR 162.539 - Must I obtain a WEEL before obtaining a WSR lease?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... AND PERMITS Wind and Solar Resource Leases Wsr Leases § 162.539 Must I obtain a WEEL before obtaining... direct result of energy resource information gathered from a WEEL activity, obtaining a WEEL is not a...

  18. Imprint cytology on microcalcifications excised by vacuum-assisted breast biopsy: a rapid preliminary diagnosis.

    PubMed

    Fotou, Maria; Oikonomou, Vassiliki; Zagouri, Flora; Sergentanis, Theodoros N; Nonni, Afroditi; Athanassiadou, Pauline; Drouveli, Theodora; Atsouris, Efstratios; Kotzia, Evagelia; Zografos, George C

    2007-04-03

    To evaluate imprint cytology in the context of specimens with microcalcifications derived from Vacuum-Assisted Breast Biopsy (VABB). A total of 93 women with microcalcifications BI-RADS 3 and 4 underwent VABB and imprint samples were examined. VABB was performed on Fischer's table using 11-gauge Mammotome vacuum probes. A mammogram of the cores after the procedure confirmed the excision of microcalcifications. For the application of imprint cytology, the cores with microcalcifications confirmed by mammogram were gently rolled against glass microscope slides and thus imprint smears were made. For rapid preliminary diagnosis Diff-Quick stain, modified Papanicolaou stain and May Grunwald Giemsa were used. Afterwards, the core was dipped into a CytoRich Red Collection fluid for a few seconds in order to obtain samples with the use of the specimen wash. After the completion of cytological procedures, the core was prepared for routine histological study. The pathologist was blind to the preliminary cytological results. The cytological and pathological diagnoses were comparatively evaluated. According to the pathological examination, 73 lesions were benign, 15 lesions were carcinomas (12 ductal carcinomas in situ, 3 invasive ductal carcinomas), and 5 lesions were precursor: 3 cases of atypical ductal hyperplasia (ADH) and 2 cases of lobular neoplasia (LN). The observed sensitivity and specificity of the cytological imprints for cancer were 100% (one-sided, 97.5% CI: 78.2%-100%). Only one case of ADH could be detected by imprint cytology. Neither of the two LN cases was detected by the imprints. The imprints were uninformative in 11 out of 93 cases (11.8%). There was no uninformative case among women with malignancy. Imprint cytology provides a rapid, accurate preliminary diagnosis in a few minutes. This method might contribute to the diagnosis of early breast cancer and possibly attenuates patients' anxiety.

  19. Histology of Testicular Biopsies Obtained for Experimental Fertility Preservation Protocol in Boys with Cancer.

    PubMed

    Pietzak, Eugene J; Tasian, Gregory E; Tasian, Sarah K; Brinster, Ralph L; Carlson, Claire; Ginsberg, Jill P; Kolon, Thomas F

    2015-11-01

    Cryopreservation of testicular tissue with subsequent reimplantation after therapy has the potential to preserve fertility for prepubertal boys with cancer. We present the histology and feasibility of testicular tissue procurement for this novel approach. We performed a prospective cohort study of boys at significant risk for treatment associated gonadotoxicity who were eligible for an experimental research protocol between 2008 and 2011. Open testicular biopsy was performed while the patients were anesthetized for another treatment related procedure. Half of the specimen was reserved for cryopreservation, while the other half was used for research purposes. Semithin sections of the biopsy specimens were evaluated for histological features and compared to age adjusted reference values. A total of 34 boys underwent biopsy between March 2008 and October 2011. Of the patients 29 had solid tumors and 5 underwent hematopoietic stem cell transplantation for benign disease. A total of 27 patients had adequate tissue for histological analysis. Median patient age was 8.7 years (IQR 2.2 to 11.5). All children had either normal (81.5% of patients) or increased (18.5%) numbers of germ cells per tubule for their age. However, 5 of 26 patients (19%) older than 6 months had no evidence of adult dark spermatogonia and 9 of 16 (56%) older than 6 years had no evidence of primary spermatocytes on biopsy, which would be expected based on age norms. These findings are suggestive of abnormal germ cell maturation. The preliminary histological findings of abnormal spermatogenesis maturation in the testes of prepubertal boys with cancer warrants further investigation. Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  20. "Family Matters": A Systematic Review of the Evidence For Family Psychoeducation For Major Depressive Disorder.

    PubMed

    Brady, Pamela; Kangas, Maria; McGill, Katherine

    2017-04-01

    The first aim of this systematic review was to evaluate the evidence for family psychoeducation (FPE) interventions for major depressive disorder (MDD). A second aim was to compare the efficacy of different modes of delivering face-to-face FPE interventions. Ten studies (based on nine distinct samples) were identified comprising four single-family studies, four multifamily studies, one single versus multifamily comparative study, and one peer-led, mixed-diagnosis study. Seven studies measured patient functioning and six reported positive outcomes. Six studies measured carer's well-being and four reported positive outcomes. Results provide preliminary evidence that FPE leads to improved outcomes for patient functioning and family-carer's well-being for persons with depression. The implications for future development and delivery of FPE interventions for MDD are discussed. © 2016 American Association for Marriage and Family Therapy.