Clinical benefit of systemic treatment in patients with advanced pancreatic and gastrointestinal neuroendocrine tumours according to ESMO-MCBS and ASCO framework.

PubMed

de Hosson, L D; van Veenendaal, L M; Schuller, Y; Zandee, W T; de Herder, W W; Tesselaar, M E T; Klümpen, H J; Walenkamp, A M E

2017-12-01

Assessment of clinical benefit of systemic treatments of rare diseases including gastroenteropancreatic neuroendocrine tumours (GEP-NET) is challenging. Recently several tools have been developed to grade the clinical benefit of cancer drugs. The European Society for Medical Oncology (ESMO) has developed the ESMO Magnitude of Clinical Benefit Scale (ESMO-MCBS). The American Society of Clinical Oncology (ASCO) has developed and revised the ASCO framework consisting of the Net Health Benefit (NHB) score juxtaposed against the costs of the treatment. In this review, we graded systemic treatments for GEP-NET patients with both frameworks. The electronic databases (PubMed and EMBASE) were searched for papers reporting comparative trials, conducted in adult GEP-NET patients in the English language. Papers were assessed according to the ESMO-MCBS and the NHB part of the ASCO revised Framework (NHB-ASCO-F) by four independent assessors, and discrepancies were discussed. The search yielded 32 trials of which 6 were eligible for grading with the ESMO-MCBS resulting in scores of 2 or 3. Eight trials were eligible for grading with the NHB-ASCO-F, resulting in scores between 37.6 and 57.4. Trials that were not primary assessable by the tools were analysed separately. Consensus between assessors was reached in 68% of trials with the ESMO-MCBS and in 23% of trials with the NHB-ASCO-F. The currently used systemic treatments for GEP-NET patients had low scores according to the NHB-ASCO-F and none could be graded as meaningful clinical beneficial according to the ESMO-MCBS. Despite the low incidence, the heterogeneous patient population and relatively long natural course of NET, future studies on new treatment modalities should aim for high clinical benefit outcomes. © The Author 2017. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Etiological classification of ischemic stroke in young patients: a comparative study of TOAST, CCS, and ASCO.

PubMed

Gökçal, Elif; Niftaliyev, Elvin; Asil, Talip

2017-09-01

Analysis of stroke subtypes is important for making treatment decisions and prognostic evaluations. The TOAST classification system is most commonly used, but the CCS and ASCO classification systems might be more useful to identify stroke etiologies in young patients whose strokes have a wide range of different causes. In this manuscript, we aim to compare the differences in subtype classification between TOAST, CCS, and ASCO in young stroke patients. The TOAST, CCS, and ASCO classification schemes were applied to 151 patients with ischemic stroke aged 18-49 years old and the proportion of subtypes classified by each scheme was compared. For comparison, determined etiologies were defined as cases with evident and probable subtypes when using the CCS scheme and cases with grade 1 and 2 subtypes but no other grade 1 subtype when using the ASCO scheme. The McNemar test with Bonferroni correction was used to assess significance. By TOAST, 41.1% of patients' stroke etiology was classified as undetermined etiology, 19.2% as cardioembolic, 13.2% as large artery atherosclerosis, 11.3% as small vessel occlusion, and 15.2% as other causes. Compared with TOAST, both CCS and ASCO assigned fewer patients to the undetermined etiology group (30.5% p < 0.001 and 26.5% p < 0.001, respectively) and assigned more patients to the small vessel occlusion category (19.9%, p < 0.001, and 21.9%, p < 0.001, respectively). Additionally, both schemes assigned more patients to the large artery atherosclerosis group (15.9 and 16.6%, respectively). The proportion of patients assigned to either the cardioembolic or the other causes etiology did not differ significantly between the three schemes. Application of the CCS and ASCO classification schemes in young stroke patients seems feasible, and using both schemes may result in fewer patients being classified as undetermined etiology. New studies with more patients and a prospective design are needed to explore this topic further.

American Society of Clinical Oncology policy statement update: genetic testing for cancer susceptibility.

PubMed

2003-06-15

As the leading organization representing cancer specialists involved in patient care and clinical research, the American Society of Clinical Oncology (ASCO) reaffirms its commitment to integrating cancer risk assessment and management, including molecular analysis of cancer predisposition genes, into the practice of oncology and preventive medicine. The primary goal of this effort is to foster expanded access to, and continued advances in, medical care provided to patients and families affected by hereditary cancer syndromes. The 1996 ASCO Statement on Genetic Testing for Cancer Susceptibility set forth specific recommendations relating to clinical practice, research needs, educational opportunities, requirement for informed consent, indications for genetic testing, regulation of laboratories, and protection from discrimination, as well as access to and reimbursement for cancer genetics services. In updating this Statement, ASCO endorses the following principles: Indications for Genetic Testing: ASCO recommends that genetic testing be offered when 1) the individual has personal or family history features suggestive of a genetic cancer susceptibility condition, 2) the test can be adequately interpreted, and 3) the results will aid in diagnosis or influence the medical or surgical management of the patient or family members at hereditary risk of cancer. ASCO recommends that genetic testing only be done in the setting of pre- and post-test counseling, which should include discussion of possible risks and benefits of cancer early detection and prevention modalities. Special Issues in Testing Children for Cancer Susceptibility: ASCO recommends that the decision to offer testing to potentially affected children should take into account the availability of evidence-based risk-reduction strategies and the probability of developing a malignancy during childhood. Where risk-reduction strategies are available or cancer predominantly develops in childhood, ASCO believes that the scope of parental authority encompasses the right to decide for or against testing. In the absence of increased risk of a childhood malignancy, ASCO recommends delaying genetic testing until an individual is of sufficient age to make an informed decision regarding such tests. As in other areas of pediatric care, the clinical cancer genetics professional should be an advocate for the best interests of the child. Counseling About Medical Management After Testing: ASCO recommends that oncologists include in pre- and post-test counseling the discussion of possible risks and benefits of cancer early-detection and prevention modalities, some of which have presumed but unproven efficacy for individuals at increased hereditary risk of cancer. Regulation of Genetic Testing: ASCO recommends strengthening regulatory oversight of laboratories that provide clinical cancer predisposition tests. These quality assurance mechanisms should include oversight of the reagents used in genetic testing, interlaboratory comparisons of reference samples, standardization of laboratory genetic test reports, and proficiency testing. Protection From Insurance and Employment Discrimination: ASCO supports establishing a federal law to prohibit discrimination by health insurance providers and employers on the basis of an individual's inherited susceptibility to cancer. Protections against genetic discrimination should apply to those with group coverage, those with individual health insurance policies, and the uninsured. Coverage of Services: ASCO supports efforts to ensure that all individuals at significantly increased risk of hereditary cancer have access to appropriate genetic counseling, testing, screening, surveillance, and all related medical and surgical interventions, which should be covered without penalty by public and private third-party payers. Confidentiality and Communication of Familial Risk: ASCO recommends that providers make concerted efforts to protect the confidentiality of genetic information. However, they should remind patients of the importance of communicating test results to family members, as part of pretest counseling and informed consent discussions. ASCO believes that the cancer care provider's obligations (if any) to at-risk relatives are best fulfilled by communication of familial risk to the person undergoing testing, emphasizing the importance of sharing this information with family members so that they may also benefit. Educational Opportunities in Genetics: ASCO is committed to continuing to provide educational opportunities for physicians and other health care providers regarding the methods of cancer risk assessment, the clinical characteristics of hereditary cancer susceptibility syndromes, and the range of issues related to genetic testing, including pre- and post-test genetic counseling, and risk management, so that health professionals may responsibly integrate the care of persons at increased genetic risk of cancer into the practice of clinical and preventive oncology. Special Issues Relating to Genetic Research on Human Tissues:ASCO recommends that all researchers proposing to use or store human biologic specimens for genetic studies should consult either the responsible institutional review board (IRB) or a comparable body specifically constituted to assess human tissue research, to determine the requirements for protection specific to the study under consideration. This consultation should take place before the project is initiated. The determination of the need for informed consent or authorization in such studies should depend on whether the research involves tests for genetic markers of known clinical significance and whether research data will be linked to protected health information, as well as other considerations specific to the study proposed. Special attention should also be paid to 1) whether future research findings will be disclosed to the research participants, 2) whether future contact of participants is planned, 3) whether and how protected health information about the tissue donors will be stored, and what will happen to study specimens after the trial ends. In addition, ASCO affirms the right of people contributing tissue to a databank to rescind their permission, in accordance with federal privacy regulations.

Integrative Therapies During and After Breast Cancer Treatment: ASCO Endorsement of the SIO Clinical Practice Guideline.

PubMed

Lyman, Gary H; Greenlee, Heather; Bohlke, Kari; Bao, Ting; DeMichele, Angela M; Deng, Gary E; Fouladbakhsh, Judith M; Gil, Brigitte; Hershman, Dawn L; Mansfield, Sami; Mussallem, Dawn M; Mustian, Karen M; Price, Erin; Rafte, Susan; Cohen, Lorenzo

2018-06-11

Purpose The Society for Integrative Oncology (SIO) produced an evidence-based guideline on use of integrative therapies during and after breast cancer treatment that was determined to be relevant to the American Society of Clinical Oncology (ASCO) membership. ASCO considered the guideline for endorsement. Methods The SIO guideline addressed the use of integrative therapies for the management of symptoms and adverse effects, such as anxiety and stress, mood disorders, fatigue, quality of life, chemotherapy-induced nausea and vomiting, lymphedema, chemotherapy-induced peripheral neuropathy, pain, and sleep disturbance. Interventions of interest included mind and body practices, natural products, and lifestyle modifications. SIO systematic reviews focused on randomized controlled trials that were published from 1990 through 2015. The SIO guideline was reviewed by ASCO content experts for clinical accuracy and by ASCO methodologists for developmental rigor. On favorable review, an ASCO Expert Panel was convened to review the guideline contents and recommendations. Results The ASCO Expert Panel determined that the recommendations in the SIO guideline-published in 2017-are clear, thorough, and based on the most relevant scientific evidence. ASCO endorsed the guideline with a few added discussion points. Recommendations Key recommendations include the following: Music therapy, meditation, stress management, and yoga are recommended for anxiety/stress reduction. Meditation, relaxation, yoga, massage, and music therapy are recommended for depression/mood disorders. Meditation and yoga are recommended to improve quality of life. Acupressure and acupuncture are recommended for reducing chemotherapy-induced nausea and vomiting. Acetyl-l-carnitine is not recommended to prevent chemotherapy-induced peripheral neuropathy because of a possibility of harm. No strong evidence supports the use of ingested dietary supplements to manage breast cancer treatment-related adverse effects. Additional information is available at: www.asco.org/supportive-care-guidelines .

[Aetiological classification of ischaemic strokes: comparison of the new A-S-C-O classification and the classification by the Spanish Society of Neurology's Cerebrovascular Disease Study Group].

PubMed

Sobrino García, P; García Pastor, A; García Arratibel, A; Vicente Peracho, G; Rodriguez Cruz, P M; Pérez Sánchez, J R; Díaz Otero, F; Vázquez Alén, P; Villanueva Osorio, J A; Gil Núñez, A

2013-09-01

The A-S-C-O classification may be better than other methods for classifying ischaemic stroke by aetiology. Our aims are to describe A-S-C-O phenotype distribution (A: atherosclerosis, S: small vessel disease, C: cardiac source, O: other causes; 1: potential cause, 2: causality uncertain, 3: unlikely to be a direct cause although disease is present) and compare them to the Spanish Society of Neurology's Cerebrovascular Disease Study Group (GEECV/SEN) classification. We will also find the degree of concordance between these classification methods and determine whether using the A-S-C-O classification delivers a smaller percentage of strokes of undetermined cause. We analysed those patients with ischaemic stroke admitted to our stroke unit in 2010 with strokes that were classified according to GEECV/SEN and A-S-C-O criteria. The study included 496 patients. The percentages of strokes caused by atherosclerosis and small vessel disease according to GEECV/SEN criteria were higher than the percentages for potential atherosclerotic stroke (A1) (14.1 vs. 11.9%; P=.16) and potential small vessel stroke (S1) (14.3 vs. 3%; P<.001). Cardioembolic stroke (C1) was more frequent (22.2 vs. 31%; P<.001). No differences between unusual cause of stroke and other potential causes (O1) were observed. Some degree of atherosclerosis was present in 53.5% of patients (A1, A2, or A3); 65.5% showed markers of small vessel disease (S1, S2, or S3), and 74.9% showed signs of cardioembolism (C1, C2, or C3). Fewer patients in the group without scores of 1 or 2 for any of the A-S-C-O phenotypes were identified as having a stroke of undetermined cause (46.6 vs. 29.2%; P<.001). The agreement between the 2 classifications ranged from κ<0.2 (small vessel and S1) to κ>0.8 (unusual causes and O1). Our results show that GEECV/SEN and A-S-C-O classifications are neither fully comparable nor consistent. Using the A-S-C-O classification provided additional information on co-morbidities and delivered a smaller percentage of strokes classified as having an undetermined cause. Copyright © 2012 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved.

Adoptive cell therapy and modulation of the tumour microenvironment: new insights from ASCO 2016.

PubMed

Khoja, Leila; Gyawali, Bishal

2016-01-01

Immuno-oncology has changed the landscape of cancer treatment in recent years. Immune checkpoint inhibitors (ICI) have shown survival advantage with long term remissions in a variety of cancers. However, there is another approach to harnessing the power of the immune system in combating cancer: the adoptive cell therapy (ACT) strategy. Although ACT is restricted to small specialized centres and has yet to deliver as much success as ICI, some important results were presented at this year's ASCO meeting. Important lessons have been learned from these studies, including the prospects and challenges ahead. In this editorial, we summarize the important studies on ACT presented at the ASCO 2016 meeting and discuss the way forward.

Adoptive cell therapy and modulation of the tumour microenvironment: new insights from ASCO 2016

PubMed Central

Khoja, Leila; Gyawali, Bishal

2016-01-01

Abstract Immuno-oncology has changed the landscape of cancer treatment in recent years. Immune checkpoint inhibitors (ICI) have shown survival advantage with long term remissions in a variety of cancers. However, there is another approach to harnessing the power of the immune system in combating cancer: the adoptive cell therapy (ACT) strategy. Although ACT is restricted to small specialized centres and has yet to deliver as much success as ICI, some important results were presented at this year’s ASCO meeting. Important lessons have been learned from these studies, including the prospects and challenges ahead. In this editorial, we summarize the important studies on ACT presented at the ASCO 2016 meeting and discuss the way forward. PMID:27610200

A Postwar Perversion of "Testimonio" in Horacio Castellanos Moya's "El asco"

ERIC Educational Resources Information Center

Thornton, Megan

2014-01-01

Salvadoran writer Horacio Castellanos Moya offers a provocative example of postwar cynicism in his 1997 novel "El asco: Thomas Bernhard en San Salvador." By telling the story of Edgardo Vega, an emigrant who returns to El Salvador in the mid-1990s after living in Canada for eighteen years, "El asco" represents the mass exodus…

Single-particle characterization of the High Arctic summertime aerosol

NASA Astrophysics Data System (ADS)

Sierau, B.; Chang, R. Y.-W.; Leck, C.; Paatero, J.; Lohmann, U.

2014-01-01

Single-particle mass spectrometric measurements were carried out in the High Arctic north of 80° during summer 2008. The campaign took place onboard the icebreaker Oden and was part of the Arctic Summer Cloud Ocean Study (ASCOS). The instrument deployed was an Aerosol Time-of-Flight Mass Spectrometer (ATOFMS) that provides information on the chemical composition of individual particles and their mixing state in real-time. Aerosols were sampled in the marine boundary layer at stations in the open ocean, in the marginal ice zone, and in the pack ice region. The largest fraction of particles detected for subsequent analysis in the size range of the ATOFMS between approximately 200 nm to 3000 nm in diameter showed mass spectrometric patterns indicating an internal mixing state and a biomass burning and/or biofuel source. The majority of these particles were connected to an air mass layer of elevated particle concentration mixed into the surface mixed layer from the upper part of the marine boundary layer. The second largest fraction was represented by sea salt particles. The chemical analysis of the over-ice sea salt aerosol revealed tracer compounds that reflect chemical aging of the particles during their long-range advection from the marginal ice zone, or open waters south thereof prior to detection at the ship. From our findings we conclude that long-range transport of particles is one source of aerosols in the High Arctic. To assess the importance of long-range particle sources for aerosol-cloud interactions over the inner Arctic in comparison to local and regional biogenic primary aerosol sources, the chemical composition of the detected particles was analyzed for indicators of marine biological origin. Only a~minor fraction showed chemical signatures of potentially ocean-derived primary particles of that kind. However, a chemical bias in the ATOFMS's detection capabilities observed during ASCOS might suggest a presence of a particle type of unknown composition and source. In general, the study suffered from low counting statistics due to the overall small number of particles found in this pristine environment, the small sizes of the prevailing aerosol below the detection limit of the ATOFMS and its low hit rate. To our knowledge, this study reports on the first in-situ single-particle mass spectrometric measurements in the marine boundary layer of the High-Arctic pack-ice region.

Single-particle characterization of the high-Arctic summertime aerosol

NASA Astrophysics Data System (ADS)

Sierau, B.; Chang, R. Y.-W.; Leck, C.; Paatero, J.; Lohmann, U.

2014-07-01

Single-particle mass-spectrometric measurements were carried out in the high Arctic north of 80° during summer 2008. The campaign took place onboard the icebreaker Oden and was part of the Arctic Summer Cloud Ocean Study (ASCOS). The instrument deployed was an aerosol time-of-flight mass spectrometer (ATOFMS) that provides information on the chemical composition of individual particles and their mixing state in real time. Aerosols were sampled in the marine boundary layer at stations in the open ocean, in the marginal ice zone, and in the pack ice region. The largest fraction of particles detected for subsequent analysis in the size range of the ATOFMS between approximately 200 and 3000 nm in diameter showed mass-spectrometric patterns, indicating an internal mixing state and a biomass burning and/or biofuel source. The majority of these particles were connected to an air mass layer of elevated particle concentration mixed into the surface mixed layer from the upper part of the marine boundary layer. The second largest fraction was represented by sea salt particles. The chemical analysis of the over-ice sea salt aerosol revealed tracer compounds that reflect chemical aging of the particles during their long-range advection from the marginal ice zone, or open waters south thereof prior to detection at the ship. From our findings we conclude that long-range transport of particles is one source of aerosols in the high Arctic. To assess the importance of long-range particle sources for aerosol-cloud interactions over the inner Arctic in comparison to local and regional biogenic primary aerosol sources, the chemical composition of the detected particles was analyzed for indicators of marine biological origin. Only a minor fraction showed chemical signatures of potentially ocean-derived primary particles of that kind. However, a chemical bias in the ATOFMS's detection capabilities observed during ASCOS might suggest the presence of a particle type of unknown composition and source. In general, the study suffered from low counting statistics due to the overall small number of particles found in this pristine environment, the small sizes of the prevailing aerosol below the detection limit of the ATOFMS, and its low hit rate. To our knowledge, this study reports on the first in situ single-particle mass-spectrometric measurements in the marine boundary layer of the high-Arctic pack ice region.

Evaluation of the ASCO Value Framework for Anticancer Drugs at an Academic Medical Center.

PubMed

Wilson, Leslie; Lin, Tracy; Wang, Ling; Patel, Tanuja; Tran, Denise; Kim, Sarah; Dacey, Katie; Yuen, Courtney; Kroon, Lisa; Brodowy, Bret; Rodondi, Kevin

2017-02-01

Anticancer drug prices have increased by an average of 12% each year from 1996 to 2014. A major concern is that the increasing cost and responsibility of evaluating treatment options are being shifted to patients. This research compared 2 value-based pricing models that were being considered for use at the University of California, San Francisco (UCSF) Medical Center to address the growing burden of high-cost cancer drugs while improving patient-centered care. The Medication Outcomes Center (MOC) in the Department of Clinical Pharmacy, University of California, San Francisco (UCSF), School of Pharmacy focuses on assessing the value of medication-related health care interventions and disseminating findings to the UCSF Medical Center. The High Cost Oncology Drug Initiative at the MOC aims to assess and adopt tools for the critical assessment and amelioration of high-cost cancer drugs. The American Society of Clinical Oncology (ASCO) Value Framework (2016 update) and a cost-effectiveness analysis (CEA) framework were identified as potential tools for adoption. To assess 1 prominent value framework, the study investigators (a) asked 8 clinicians to complete the ASCO Value Framework for 11 anticancer medications selected by the MOC; (b) reviewed CEAs assessing the drugs; (c) generated descriptive statistics; and (d) analyzed inter-rater reliability, convergence validity, and ranking consistency. On the scale of -20 to 180, the mean ASCO net health benefit (NHB) total score across 11 drugs ranged from 7.6 (SD = 7.8) to 53 (SD = 9.8). The Kappa coefficient (κ) for NHB scores across raters was 0.11, which is categorized as "slightly reliable." The combined κ score was 0.22, which is interpreted as low to fair inter-rater reliability. Convergent validity indicates that the correlation between NHB scores and CEA-based incremental cost-effectiveness ratios (ICERs) was low (-0.215). Ranking of ICERs, ASCO scores, and wholesale acquisition costs indicated different results between frameworks. The ASCO Value Framework requires further specificity before use in a clinical setting, since it currently results in low inter-rater reliability and validity. Furthermore, ASCO scores were unable to discriminate between drugs providing the most and least value. The evaluation provides specific areas of weakness that can be addressed in future updates of the ASCO framework to improve usability. Meanwhile, the UCSF Medical Center should rely on CEAs, which are highly accessible for the highlighted cancer drugs. The MOC role can include summarizing and disseminating available CEA studies for interpretation by clinicians and financial counselors around drug value. Funding for this research was contributed by the University of California, San Francisco, Medical Center Campus Strategic Initiative Program. The authors have no conflicts of interest to disclose. Study concept and design were contributed primarily by Wilson, along with Wang and Patel. Kim, Dacey, and Yuen collected the data, and data interpretation was performed by Wilson and Lin. The manuscript was written by Wilson, Lin, Wang, and Tran and revised by Lin, Redondi, Brodowy, and Kroon.

Treatment of Malignant Pleural Mesothelioma: American Society of Clinical Oncology Clinical Practice Guideline.

PubMed

Kindler, Hedy L; Ismaila, Nofisat; Armato, Samuel G; Bueno, Raphael; Hesdorffer, Mary; Jahan, Thierry; Jones, Clyde Michael; Miettinen, Markku; Pass, Harvey; Rimner, Andreas; Rusch, Valerie; Sterman, Daniel; Thomas, Anish; Hassan, Raffit

2018-05-01

Purpose To provide evidence-based recommendations to practicing physicians and others on the management of malignant pleural mesothelioma. Methods ASCO convened an Expert Panel of medical oncology, thoracic surgery, radiation oncology, pulmonary, pathology, imaging, and advocacy experts to conduct a literature search, which included systematic reviews, meta-analyses, randomized controlled trials, and prospective and retrospective comparative observational studies published from 1990 through 2017. Outcomes of interest included survival, disease-free or recurrence-free survival, and quality of life. Expert Panel members used available evidence and informal consensus to develop evidence-based guideline recommendations. Results The literature search identified 222 relevant studies to inform the evidence base for this guideline. Recommendations Evidence-based recommendations were developed for diagnosis, staging, chemotherapy, surgical cytoreduction, radiation therapy, and multimodality therapy in patients with malignant pleural mesothelioma. Additional information is available at www.asco.org/thoracic-cancer-guidelines and www.asco.org/guidelineswiki .

Pattern of Duplicate Presentations at National Hematology-Oncology Meetings: Influence of the Pharmaceutical Industry.

PubMed

Ramchandren, Radhakrishnan; Schiffer, Charles A

2016-03-01

The major large US hematology-oncology meetings sponsored by the American Society of Hematology (ASH) and American Society of Clinical Oncology (ASCO) have specific guidelines in place discouraging submission of scientific information presented previously at other meetings. Nonetheless, duplicate submissions are frequent. The incidence and motivations for duplicate hematologic presentations and the influence of the pharmaceutical industry on this process have not been thoroughly analyzed. Therefore, were viewed four consecutive ASH and ASCO meetings to assess the frequency of duplicate abstract presentations. All abstracts presented at ASCO2010 in the area of malignant hematology were compared with abstracts from ASCO and ASH 2009 and ASH 2010, and funding sources were reviewed. More than half (54%) of all abstracts submitted to ASCO 2010 acknowledged pharmaceutical company support. Almost one third (31%) of ASCO 2010 abstracts were resubmitted in the 2-year time period, and it was notable that a high fraction (75%) of these duplicate abstracts had pharmaceutical industry sponsorship, compared with 42% of the abstracts that were submitted only once. Despite current guidelines prohibiting duplicate abstract presentation, a substantial proportion (31%) of abstracts at large international hematology-oncology meetings are duplicative, with potential negative consequences. In addition, a disproportionate percentage of the duplicate abstracts rely on pharmaceutical industry support (75%), suggesting that marketing strategies may be a motivation for some of these repetitive submissions.

The American Society of Clinical Oncology's Efforts to Support Global Cancer Medicine

PubMed Central

El-Saghir, Nagi S.; Cufer, Tanja; Cazap, Eduardo; de Guzman, Roselle; Othieno-Abinya, Nicholas Anthony; Sanchez, Jose Angel; Pyle, Doug

2016-01-01

Despite much progress in the management of malignant diseases, the number of new cases and cancer-related deaths continues to rise around the world. More than half of new cases occur in economically developing countries, where more than two thirds of cancer deaths are expected. However, implementation of all necessary steps to accomplish the dissemination of state-of-the-art prevention, diagnosis, and management will require increased allocation of resources, and, more importantly, harmonization of the efforts of hundreds of national and international public health agencies, policy-setting bodies, governments, pharmaceutical companies, and philanthropic organizations. More than 30% of the members of the American Society of Clinical Oncology (ASCO) reside and practice outside US borders, and more than half of attendees at all of the scientific congresses and symposia organized by ASCO are international. As cancer has become an increasingly global disease, ASCO has evolved as a global organization. The ASCO Board of Directors currently includes members from France, Brazil, and Canada. In 2013, the ASCO Board of Directors identified a number of strategic priorities for the future. Recognizing the importance of non-US members to the society, their first strategic priority was improving the society's service to non-US members and defining these members' identity in the international oncology community. This article reviews current ASCO activities in the international arena and its future plans in global oncology. PMID:26578614

American Society of Clinical Oncology policy for relationships with companies: background and rationale.

PubMed

2013-06-01

The American Society of Clinical Oncology's (ASCO's) new conflict of interest policy reflects a commitment to transparency and independence in the development and presentation of scientific and educational content. ASCO supports thorough and accessible disclosure of financial relationships with companies at institutional and individual levels and calls for rigorous evaluation of content in light of the information disclosed. For abstracts and articles presenting original research, ASCO holds first, last, and corresponding authors to a clear standard of independence. In imposing restrictions, the new policy focuses on the role of these authors rather than of the principal investigator(s) as in the previous policy. ASCO remains actively engaged with the broader scientific community in seeking and implementing efficient, effective approaches to conflict of interest management.

Preventing and Treating Blood Clots

MedlinePlus

... best possible care, the American Society of Clinical Oncology (ASCO) asks its medical experts to develop recommendations ... and caregivers, from the American Society of Clinical Oncology (ASCO), the voice of the world’s cancer physicians ...

Measuring the Value of New Drugs: Validity and Reliability of 4 Value Assessment Frameworks in the Oncology Setting.

PubMed

Bentley, Tanya G K; Cohen, Joshua T; Elkin, Elena B; Huynh, Julie; Mukherjea, Arnab; Neville, Thanh H; Mei, Matthew; Copher, Ronda; Knoth, Russell; Popescu, Ioana; Lee, Jackie; Zambrano, Jenelle M; Broder, Michael S

2017-06-01

Several organizations have developed frameworks to systematically assess the value of new drugs. To evaluate the convergent validity and interrater reliability of 4 value frameworks to understand the extent to which these tools can facilitate value-based treatment decisions in oncology. Eight panelists used the American Society of Clinical Oncology (ASCO), European Society for Medical Oncology (ESMO), Institute for Clinical and Economic Review (ICER), and National Comprehensive Cancer Network (NCCN) frameworks to conduct value assessments of 15 drugs for advanced lung and breast cancers and castration-refractory prostate cancer. Panelists received instructions and published clinical data required to complete the assessments, assigning each drug a numeric or letter score. Kendall's Coefficient of Concordance for Ranks (Kendall's W) was used to measure convergent validity by cancer type among the 4 frameworks. Intraclass correlation coefficients (ICCs) were used to measure interrater reliability for each framework across cancers. Panelists were surveyed on their experiences. Kendall's W across all 4 frameworks for breast, lung, and prostate cancer drugs was 0.560 (P= 0.010), 0.562 (P = 0.010), and 0.920 (P < 0.001), respectively. Pairwise, Kendall's W for breast cancer drugs was highest for ESMO-ICER and ICER-NCCN (W = 0.950, P = 0.019 for both pairs) and lowest for ASCO-NCCN (W = 0.300, P = 0.748). For lung cancer drugs, W was highest pairwise for ESMO-ICER (W = 0.974, P = 0.007) and lowest for ASCO-NCCN (W = 0.218, P = 0.839); for prostate cancer drugs, pairwise W was highest for ICER-NCCN (W = 1.000, P < 0.001) and lowest for ESMO-ICER and ESMO-NCCN (W = 0.900, P = 0.052 for both pairs). When ranking drugs on distinct framework subdomains, Kendall's W among breast cancer drugs was highest for certainty (ICER, NCCN: W = 0.908, P = 0.046) and lowest for clinical benefit (ASCO, ESMO, NCCN: W = 0.345, P = 0.436). Among lung cancer drugs, W was highest for toxicity (ASCO, ESMO, NCCN: W = 0. 944, P < 0.001) and lowest for certainty (ICER, NCCN: W = 0.230, P = 0.827); and among prostate cancer drugs, it was highest for quality of life (ASCO, ESMO: W = 0.986, P = 0.003) and lowest for toxicity (ASCO, ESMO, NCCN: W = 0.200, P = 0.711). ICC (95% CI) for ASCO, ESMO, ICER, and NCCN were 0.800 (0.660-0.913), 0.818 (0.686-0.921), 0.652 (0.466-0.834), and 0.153 (0.045-0.371), respectively. When scores were rescaled to 0-100, NCCN provided the narrowest band of scores. When asked about their experiences using the ASCO, ESMO, ICER, and NCCN frameworks, panelists generally agreed that the frameworks were logically organized and reasonably easy to use, with NCCN rated somewhat easier. Convergent validity among the ASCO, ESMO, ICER, and NCCN frameworks was fair to excellent, increasing with clinical benefit subdomain concordance and simplicity of drug trial data. Interrater reliability, highest for ASCO and ESMO, improved with clarity of instructions and specificity of score definitions. Continued use, analyses, and refinements of these frameworks will bring us closer to the ultimate goal of using value-based treatment decisions to improve patient care and outcomes. This work was funded by Eisai Inc. Copher and Knoth are employees of Eisai Inc. Bentley, Lee, Zambrano, and Broder are employees of Partnership for Health Analytic Research, a health services research company paid by Eisai Inc. to conduct this research. For this study, Cohen, Huynh, and Neville report fees from Partnership for Health Analytic Research. Outside of this study, Cohen receives grants and direct consulting fees from various companies that manufacture and market pharmaceuticals. Mei reports a grant from Eisai Inc. during this study. The other authors have no disclosures to report. Study concept and design were contributed by Bentley and Broder, with assistance from Elkin and Cohen. Bentley took the lead in data collection, along with Elkin, Huynh, Mukherjea, Neville, Mei, Popescu, Lee, and Zambrano. Data interpretation was performed by Bentley and Broder, along with Elkin, Cohen, Copher, and Knoth. The manuscript was written primarily by Bentley, along with Elkin and Broder, and revised by Bentley, Broder, Elkin, Cohen, Copher, and Knoth. Select components of this work's methods were presented at ISPOR 19th Annual European Congress held in Vienna, Austria, October 29-November 2, 2016, and Society for Medical Decision Making 38th Annual North American Meeting held in Vancouver, Canada, October 23-26, 2016.

NCI at ASCO: A brief overview on women's cancers

Cancer.gov

The 2014 annual American Society of Clinical Oncology (ASCO) meeting in Chicago in June highlighted results from a number of NCI-supported and -sponsored clinical trial results in women’s cancers. Taken together, these results represent important advances

Utility of two cancer organization websites for a multiethnic, public hospital oncology population: comparative cross-sectional survey.

PubMed

Nguyen, Katherine D; Hara, Belinda; Chlebowski, Rowan T

2005-07-01

While information websites have been developed by major cancer organizations, their appropriateness for patients in multiethnic, multilingual public hospital settings has received limited attention. The objective of the study was to determine the utility of cancer information websites for a public hospital patient population. A 70-item questionnaire was developed to evaluate cancer information seeking behavior, Internet access and use, and content appropriateness of two cancer information websites: People Living with Cancer from the American Society of Clinical Oncology (ASCO) and Breast Cancer Info from the Susan Komen Breast Cancer Foundation (SKF). Interviews were conducted with consecutive consenting oncology patients seen in a public hospital oncology clinic. Fifty-nine persons participated in the survey. The response rate was 80%. Participants were Caucasian (25%), African American (19%), Hispanic (42%), and Asian/Pacific Islander (11%). English was the primary language in 53% of participants, 56% had a high school education or less, and 74% had an annual income less than US 35000 dollars. With respect to computer and Internet use, 71% had computer access, and 44% searched for cancer information online, with more being interested in obtaining online information in the future (63%). Participants who had computer access were likely to be English speaking (P = .04). Those less likely to have previously used a computer tended to have a lower annual income (P = .02) or to be males aged 55 years or older (P < .05). When shown sample content from the two websites, almost all participants stated that it was "easy to understand" (ASCO 96%, SKF 96%) and had "easy to understand terms" (ASCO 94%, SKF 92%). Somewhat fewer respondents agreed that the websites provided "information they could use" (ASCO 88%, SKF 80%) or that they would return to these websites (ASCO 73%, SKF 68%). The majority planned to "discuss website information with their oncologists" (ASCO 82%, SKF 70%). Multiethnic, multilingual cancer patients at a public county hospital commonly had Internet access and found the content of two websites representative of major cancer organizations to be both understandable and useful.

NCI Director Norman Sharpless’s ASCO 2018 Remarks

Cancer.gov

In this video, NCI Director Dr. Norman E. Sharpless discusses the future of cancer research at the 2018 American Society of Clinical Oncology (ASCO) annual meeting in Chicago. Learn more about his focus on basic science, workforce development, big data, and clinical trials.

NCI Director Norman Sharpless’s ASCO 2018 Remarks-The Power and Promise of Cancer Research

Cancer.gov

NCI Director Dr. Norman E. Sharpless discusses the future of cancer research at the 2018 American Society of Clinical Oncology (ASCO) annual meeting in Chicago. Learn more about his focus on basic science, workforce development, big data, and clinical trials.

Focus on the President.

ERIC Educational Resources Information Center

Optometric Education, 1996

1996-01-01

In an interview, the incoming president of the Association of Schools and Colleges of Optometry (ASCO), Thomas L. Lewis, discusses his goals for the association, the challenges facing optometric education in the next decade, cooperation between ASCO and other professional organizations in optometry, his mentors in the profession, his focus as a…

Source and Fate of Sediments in the Bahia de Anasco, Puerto Rico

NASA Astrophysics Data System (ADS)

Webb, R. M.

2005-12-01

Sediments and wastewater mix in the insular marine waters of the Bah'{i}a de Añasco near Mayag{u}ez, Puerto Rico. Trace metal concentrations in fine sediments deposited in the bay were measured to assess potential impact of the ocean outfall on the biota and habitats that include coral reefs. A Q-mode factor analysis of elemental compositions identified three sediment sources and their relative proportions in 51 core and surficial samples collected from the bay and within the coral reefs: (1) sediments discharged by the R'{i}o Grande de Añasco; (2) calcareous skeletal remains; and (3) sediments discharged by the R'{i}o Guanajibo. The nickel and chromium derived from laterite deposits provide a unique fingerprint for sediments discharged from the R'{i}o Guanajibo. Naturally occurring concentrations of these elements exceed Probable Effect Limits (PEL's: 42 mg/kg for nickel and 160 mg/kg for chromium) in sediments deposited near the river mouth. The detection of mercury at 1 mg/kg in one sample from a core recovered near the wastewater outfall was the only indication of a possible outfall source in the data set. The temporal and spatial variations in source fractions proved useful in determining relative frequencies of historic floods and steady-state circulation patterns off the west coast of Puerto Rico.

Tracking the Workforce: The American Society of Clinical Oncology Workforce Information System

PubMed Central

Kirkwood, M. Kelsey; Kosty, Michael P.; Bajorin, Dean F.; Bruinooge, Suanna S.; Goldstein, Michael A.

2013-01-01

Purpose: In anticipation of oncologist workforce shortages projected as part of a 2007 study, the American Society of Clinical Oncology (ASCO) worked with a contractor to create a workforce information system (WIS) to assemble the latest available data on oncologist supply and cancer incidence and prevalence. ASCO plans to publish findings annually, reporting on new data and tracking trends over time. Methods: The WIS report is composed of three sections: supply, new entrants, and cancer incidence and prevalence. Tabulations of the number of oncologists in the United States are derived mainly from the American Medical Association Physician Masterfile. Information on fellows and residents in the oncology workforce pipeline come from published sources such as Journal of the American Medical Association. Incidence and prevalence estimates are published by the American Cancer Society and National Cancer Institute. Results: The WIS reports a total of 13,084 oncologists working in the United States in 2011. Oncologists are defined as those physicians who designate hematology, hematology/oncology, or medical oncology as their specialty. The WIS compares the characteristics of these oncologists with those of all physicians and tracks emerging trends in the physician training pipeline. Conclusion: Observing characteristics of the oncologist workforce over time allows ASCO to identify, prioritize, and evaluate its workforce initiatives. Accessible figures and reports generated by the WIS can be used by ASCO and others in the oncology community to advocate for needed health care system and policy changes to help offset future workforce shortages. PMID:23633965

An immunohistochemical and fluorescence in situ hybridization-based comparison between the Oracle HER2 Bond Immunohistochemical System, Dako HercepTest, and Vysis PathVysion HER2 FISH using both commercially validated and modified ASCO/CAP and United Kingdom HER2 IHC scoring guidelines.

PubMed

O'Grady, Anthony; Allen, David; Happerfield, Lisa; Johnson, Nicola; Provenzano, Elena; Pinder, Sarah E; Tee, Lilian; Gu, Mai; Kay, Elaine W

2010-12-01

Immunohistochemistry (IHC) is used as the frontline assay to determine HER2 status in invasive breast cancer patients. The aim of the study was to compare the performance of the Leica Oracle HER2 Bond IHC System (Oracle) with the current most readily accepted Dako HercepTest (HercepTest), using both commercially validated and modified ASCO/CAP and UK HER2 IHC scoring guidelines. A total of 445 breast cancer samples from 3 international clinical HER2 referral centers were stained with the 2 test systems and scored in a blinded fashion by experienced pathologists. The overall agreement between the 2 tests in a 3×3 (negative, equivocal and positive) analysis shows a concordance of 86.7% and 86.3%, respectively when analyzed using commercially validated and modified ASCO/CAP and UK HER2 IHC scoring guidelines. There is a good concordance between the Oracle and the HercepTest. The advantages of a complete fully automated test such as the Oracle include standardization of key analytical factors and improved turn around time. The implementation of the modified ASCO/CAP and UK HER2 IHC scoring guidelines has minimal effect on either assay interpretation, showing that Oracle can be used as a methodology for accurately determining HER2 IHC status in formalin fixed, paraffin-embedded breast cancer tissue.

Survey of Implementation of Antiemetic Prescription Standards in Indian Oncology Practices and Its Adherence to the American Society of Clinical Oncology Antiemetic Clinical Guideline

PubMed Central

Patil, Vijay; Noronha, Vanita; Joshi, Amit; Parikh, Purvish; Bhattacharjee, Atanu; Chakraborty, Santam; Jandyal, Sunny; Muddu, Vamshi; Ramaswamy, Anant; Babu, K. Govinda; Lokeshwar, Nilesh; Hingmire, Sachin; Ghadyalpatil, Nikhil; Banavali, Shripad

2017-01-01

Purpose Adherence to international antiemetic prophylaxis guidelines like those of ASCO can result in better control of chemotherapy-induced nausea and vomiting; however, the extent of implementation of such guidelines in India is unknown. Therefore, this survey was planned. Methods This study was an anonymized cross-sectional survey approved by the ethics committee. Survey items were generated from the clinical questions given in the ASCO guidelines. The survey was disseminated through personal contacts at an oncology conference and via e-mail to various community oncology centers across India. The B1, B2, and B3 domains included questions regarding the optimal antiemetic prophylaxis for high, moderate, and low-minimal emetogenic regimens. Results Sixty-six (62.9%) of 105 responded and 65 centers (98.5%) were aware of the published guidelines. The partial, full, and no implementation scores were 92.5%, 4.5%, and 3.0%, respectively. Full implementation was better for the low-minimal emetogenic regimens (34.8%) than the highly emetogenic regimens (6.1%). The three most frequent reasons for hampered implementation of ASCO guidelines in routine chemotherapy practice cited by centers were a lack of sensitization (26 centers; 39.4%), lack of national guidelines (12 centers; 18.2%), and lack of administrative support (10 centers; 15.2%). Conclusion Awareness regarding ASCO antiemetic guidelines is satisfactory in Indian oncology practices; however, there is a need for sensitization of oncologists toward complete implementation of these guidelines in their clinical practice. PMID:28831443

Delivery of meaningful cancer care: a retrospective cohort study assessing cost and benefit with the ASCO and ESMO frameworks.

PubMed

Del Paggio, Joseph C; Sullivan, Richard; Schrag, Deborah; Hopman, Wilma M; Azariah, Biju; Pramesh, C S; Tannock, Ian F; Booth, Christopher M

2017-07-01

The American Society of Clinical Oncology (ASCO) and the European Society for Medical Oncology (ESMO) have developed frameworks that quantify survival gains in light of toxicity and quality of life to assess the benefits of cancer therapies. We applied these frameworks to a cohort of contemporary randomised controlled trials to explore agreement between the two approaches and to assess the relation between treatment benefit and cost. We identified all randomised controlled trials of systemic therapies in non-small-cell lung cancer, breast cancer, colorectal cancer, and pancreatic cancer published between Jan 1, 2011, and Dec 31, 2015, and assessed their abstracts and methods. Trials were eligible for inclusion in our cohort if significant differences favouring the experimental group in a prespecified primary or secondary outcome were reported (secondary outcomes were assessed only if primary outcomes were not significant). We assessed trial endpoints with the ASCO and ESMO frameworks at two timepoints 3 months apart to confirm intra-rater reliability. Cohen's κ statistic was calculated to establish agreement between the two frameworks on the basis of the median ASCO score, which was used as an arbitrary threshold of benefit, and the framework-recommended ESMO threshold. Differences in monthly drug cost between the experimental and control groups of each randomised controlled trial (ie, incremental drug cost) were derived from 2016 average wholesale prices. 109 randomised controlled trials were eligible for inclusion, 42 (39%) in non-small-cell lung cancer, 36 (33%) in breast cancer, 25 (23%) in colorectal cancer, and six (6%) in pancreatic cancer. ASCO scores ranged from 2 to 77; median score was 25 (IQR 16-35). 41 (38%) trials met the benefit thresholds in the ESMO framework. Agreement between the two frameworks was fair (κ=0·326). Among the 100 randomised controlled trials for which drug costing data were available, ASCO benefit score and monthly incremental drug costs were negatively correlated (ρ=-0·207; p=0·039). Treatments that met ESMO benefit thresholds had a lower median incremental drug cost than did those that did not meet benefit thresholds (US$2981 [IQR 320-9059] vs $8621 [1174-13 930]; p=0·018). There is only fair correlation between these two major value care frameworks, and negative correlations between framework outputs and drug costs. Delivery of optimal cancer care in a sustainable health system will necessitate future oncologists, investigators, and policy makers to reconcile the disconnect between drug cost and clinical benefit. None. Copyright © 2017 Elsevier Ltd. All rights reserved.

Air Support Control Officer Individual Position Training Simulation

DTIC Science & Technology

2017-06-01

Analysis design development implementation evaluation ASCO Air support control officer ASLT Air support liaison team ASNO Air support net operator...Instructional system design LSTM Long-short term memory MACCS Marine Air Command and Control System MAGTF Marine Air Ground Task Force MASS Marine Air...information to designated MACCS agencies. ASCOs play an important part in facilitating the safe and successful conduct of air operations in DASC- controlled

[American Society of Clinical Oncology (ASCO) 2012 essential data: the editorial board of the Bulletin du Cancer point of view].

PubMed

Magné, Nicolas; Bay, Jacques-Olivier; Blay, Jean-Yves; Gonçalves, Anthony; Massard, Christophe; Thariat, Juliette; Wislez, Marie; André, Thierry; Vignot, Stéphane

2012-12-01

We know where we are but do we know where we are going in the next future? Each year ASCO meeting leads to us hopes and dreams for the best management of our patients. With a past view over six months, we will try to highlight useful informations across the manuscript whatever the locations.

Global initiatives to enhance cancer care in areas of limited resources: what ASCO members are doing and how you can become involved.

PubMed

Lichtman, Stuart M

2013-01-01

Cancer is the leading cause of death worldwide. In 2008, 7.6 million deaths were attributable to cancer, representing 13% of all deaths. It is estimated that approximately 30% of cancer deaths are attributable to the five leading behavioral and dietary risks. These include high body mass index, low fruit and vegetable intake, lack of physical activity, and tobacco and alcohol use. A number of viral infections, such as hepatitis B and C and HPV, are responsible for approximately 20% of cancer deaths. Approximately 70% of cancer deaths occurred in low- and middle-income countries. Because of the increased numbers of elderly individuals and improved control of comorbidity, deaths from cancer worldwide are projected to continue rising, with an estimated 13.1 million deaths in 2030. To meet this need, the American Society of Clinical Oncology (ASCO) has evolved into a truly international organization. Over one-third of ASCO members practice in over 100 countries, representing the world's largest collection of expertise and insight into the treatment of cancer. More than one-half of ASCO's Annual Meeting attendees come from outside the United States. The Journal of Clinical Oncology is read by more than 24,000 subscribers worldwide and is available in a number of different languages. To fulfill its mission, ASCO has a number of international programs for sharing knowledge and providing the tools to assist clinicians worldwide in treating their patients. These programs include mentoring and knowledge exchange, education initiatives, and scientific and educational meetings. This provides ample opportunity for involvement to enhance cancer care worldwide.

A Multiorganization Approach to Improving Palliative Care in Honduras.

PubMed

Kennedy Sheldon, Lisa; Dahlin, Constance; Maingi, Shail; Sanchez, Jose

2017-01-01

Since 2011, oncology nurses and physicians in the United States have been volunteering in Honduras with the International Cancer Corps (ICC), organized by the American Society of Clinical Oncology (ASCO), in partnership with Health Volunteers Overseas (HVO). In this article, the authors will summarize the work of the ASCO/HVO ICC teams that developed educational programs with local partners to improve cancer and palliative care in Honduras.

Self-Fashioning through Glamour and Punk in East Los Angeles: Patssi Valdez in Asco's "Instant Mural" and "A La Mode"

ERIC Educational Resources Information Center

McMahon, Marci R.

2011-01-01

Patssi Valdez, one of the most influential yet understudied female artists of the Chicana/o movement, was the only original and long-term female member of the 1970s art collective Asco. Through the visual discourses of pachuca glamour and punk, Valdez negotiated and exploited the gendered ideologies that visually put her at the center of the…

Model Intercomparison of CCN-Limited Arctic Clouds During ASCOS

NASA Astrophysics Data System (ADS)

Stevens, Robin; Dearden, Chris; Dimetrelos, Antonios; Eirund, Gesa; Possner, Anna; Raatikainen, Tomi; Loewe, Katharina; Hill, Adrian; Shipway, Ben; Connolly, Paul; Ekman, Annica; Hoose, Corinna; Laaksonen, Ari; de Leeuw, Gerrit; Kolmonen, Pekka; Saponaro, Giulia; Field, Paul; Carlsaw, Ken

2017-04-01

Future decreases in Arctic sea ice are expected to increase fluxes of aerosol and precursor gases from the open ocean surface within the Arctic. The resulting increase in cloud condensation nuclei (CCN) concentrations would be expected to result in increased cloud albedo (Struthers et al, 2011), leading to potentially large changes in radiative forcings. However, Browse et al. (2014) have shown that these increases in condensable material could also result in the growth of existing particles to sizes where they are more efficiently removed by wet deposition in drizzling stratocumulus clouds, ultimately decreasing CCN concentrations in the high Arctic. Their study was limited in that it did not simulate alterations of dynamics or cloud properties due to either changes in heat and moisture fluxes following sea­-ice loss or changing aerosol concentrations. Taken together, these results show that significant uncertainties remain in trying to quantify aerosol­-cloud processes in the Arctic system. The current representation of these processes in global climate models is most likely insufficient to realistically simulate long­-term changes. In order to better understand the microphysical processes currently governing Arctic clouds, we perform a model intercomparison of summertime high Arctic (>80N) clouds observed during the 2008 ASCOS campaign. The intercomparison includes results from three large eddy simulation models (UCLALES-SALSA, COSMO-LES, and MIMICA) and three numerical weather prediction models (COSMO-NWP, WRF, and UM-CASIM). The results of these experiments will be used as a basis for sensitivity studies on the impact of sea-ice loss on Arctic clouds through changes in aerosol and precursor emissions as well as changes in latent and sensible heat fluxes. Browse, J., et al., Atmos. Chem. Phys., 14(14), 7543-7557, doi:10.5194/acp-14-7543-2014, 2014. Struthers, H., et al., Atmos. Chem. Phys., 11(7), 3459-3477, doi:10.5194/acp-11-3459-2011, 2011.

Basic Cancer Terms

MedlinePlus

... oncologists. Learn more about the types of oncologists . Oncology The study of cancer. Pathologist A doctor who ... and caregivers, from the American Society of Clinical Oncology (ASCO), the voice of the world’s cancer physicians ...

American Society of Clinical Oncology Policy Statement Update: Genetic and Genomic Testing for Cancer Susceptibility.

PubMed

Robson, Mark E; Bradbury, Angela R; Arun, Banu; Domchek, Susan M; Ford, James M; Hampel, Heather L; Lipkin, Stephen M; Syngal, Sapna; Wollins, Dana S; Lindor, Noralane M

2015-11-01

The American Society of Clinical Oncology (ASCO) has long affirmed that the recognition and management of individuals with an inherited susceptibility to cancer are core elements of oncology care. ASCO released its first statement on genetic testing in 1996 and updated that statement in 2003 and 2010 in response to developments in the field. In 2014, the Cancer Prevention and Ethics Committees of ASCO commissioned another update to reflect the impact of advances in this area on oncology practice. In particular, there was an interest in addressing the opportunities and challenges arising from the application of massively parallel sequencing-also known as next-generation sequencing-to cancer susceptibility testing. This technology introduces a new level of complexity into the practice of cancer risk assessment and management, requiring renewed effort on the part of ASCO to ensure that those providing care to patients with cancer receive the necessary education to use this new technology in the most effective, beneficial manner. The purpose of this statement is to explore the challenges of new and emerging technologies in cancer genetics and provide recommendations to ensure their optimal deployment in oncology practice. Specifically, the statement makes recommendations in the following areas: germline implications of somatic mutation profiling, multigene panel testing for cancer susceptibility, quality assurance in genetic testing, education of oncology professionals, and access to cancer genetic services. © 2015 by American Society of Clinical Oncology.

Cohort profile: the Nordic Antireflux Surgery Cohort (NordASCo)

PubMed Central

Wahlin, Karl; Artama, Miia; Brusselaers, Nele; Färkkilä, Martti; Lynge, Elsebeth; Mattsson, Fredrik; Pukkala, Eero; Romundstad, Pål; Tryggvadóttir, Laufey; von Euler-Chelpin, My; Lagergren, Jesper

2017-01-01

Purpose To describe a newly created all-Nordic cohort of patients with gastro-oesophageal reflux disease (GORD), entitled the Nordic Antireflux Surgery Cohort (NordASCo), which will be used to compare participants having undergone antireflux surgery with those who have not regarding risk of cancers, other diseases and mortality. Participants Included were individuals with a GORD diagnosis recorded in any of the nationwide patient registries in the Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) in 1964–2014 (with various start and end years in different countries). Data regarding cancer, other diseases and mortality were retrieved from the nationwide registries for cancer, patients and causes of death, respectively. Findings to date The NordASCo includes 945 153 individuals with a diagnosis of GORD. Of these, 48 433 (5.1%) have undergone primary antireflux surgery. Median age at primary antireflux surgery ranged from 47 to 52 years in the different countries. The coding practices of GORD seem to have differed between the Nordic countries. Future plans The NordASCo will initially be used to analyse the risk of developing known or potential GORD-related cancers, that is, tumours of the oesophagus, stomach, larynx, pharynx and lung, and to evaluate the mortality in the short-term and long-term perspectives. Additionally, the cohort will be used to evaluate the risk of non-malignant respiratory conditions that might be caused by aspiration of gastric contents. PMID:28600380

Analysis of molecular subtypes for the increased HER2 equivocal cases caused by application of the updated 2013 ASCO/CAP HER2 testing guidelines in breast cancer.

PubMed

Guo, Lei; Yuan, Pei; Zhang, Jing; Ling, Yun; Li, Wenbin; Zhao, Bohui; Ying, Jianming; Xuan, Lixue

2017-11-01

Accurate testing of the status of human epidermal growth factor receptor type 2 (HER2) is a prerequisite for HER2-directed therapy. The American Society of Clinical Oncology (ASCO) and the College of American Pathologists (CAP) published joint guideline recommendations for HER2 testing in breast cancer in 2007 and it was updated in 2013. We compared the HER2 gene amplification status based on these two guidelines and analyzed the molecular characteristics of the equivocal cases. A total of 1894 patient samples were analyzed for both immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). HER2 FISH amplification was examined and re-assessed using 2013 guidelines. According to the 2013 ASCO/CAP recommendations, 763 (40.3%) cases were classified as HER2 positive compared with 729 (38.5%) cases defined by 2007 guidelines. There was a significant increase of 6.1% in the proportion of HER2 FISH equivocal cases that were interpreted using ASCO/CAP 2013 (7.3%) compared with 2007 (1.2%) guidelines (P < 0.001). Of 138 FISH equivocal cases defined by 2013 guidelines, 125 cases were IHC2+ and 13 cases were IHC1+. These 125 cases included 4 double equivocal cases which were defined as equivocal by both 2007 and 2013 guidelines and 121 cases whose status was changed from negative defined by 2007 guidelines to equivocal defined by 2013 guidelines. Compared with luminal A type and luminal B type respectively, these 121 equivocal cases demonstrated no significant difference with luminal B type in T stage and N stage (P = 0.192, P = 0.421). When we divided the luminal B type into two parts that included HER2 negative cases and HER2 positive cases, the equivocal cases also showed no significant difference with these two subtypes in T stage and N stage. Our study suggested that implementation of the revised ASCO/CAP 2013 guidelines resulted in an increase of 1.7% in overall HER2 positivity rate and of 6.1% in equivocal cases. Pathological analysis revealed that these equivocal cases exhibit similar biological behavior with luminal B type tumors. Clinical utility data on targeted therapy in equivocal patients should be further investigated.

The impact of the privacy rule on cancer research: variations in attitudes and application of regulatory standards.

PubMed

Goss, Elizabeth; Link, Michael P; Bruinooge, Suanna S; Lawrence, Theodore S; Tepper, Joel E; Runowicz, Carolyn D; Schilsky, Richard L

2009-08-20

The American Society of Clinical Oncology (ASCO) Cancer Research Committee designed a qualitative research project to assess the attitudes of cancer researchers and compliance officials regarding compliance with the US Privacy Rule and to identify potential strategies for eliminating perceived or real barriers to achieving compliance. A team of three interviewers asked 27 individuals (13 investigators and 14 compliance officials) from 13 institutions to describe the anticipated approach of their institutions to Privacy Rule compliance in three hypothetical research studies. The interviews revealed that although researchers and compliance officials share the view that patients' cancer diagnoses should enjoy a high level of privacy protection, there are significant tensions between the two groups related to the proper standards for compliance necessary to protect patients. The disagreements are seen most clearly with regard to the appropriate definition of a "future research use" of protected health information in biospecimen and data repositories and the standards for a waiver of authorization for disclosure and use of such data. ASCO believes that disagreements related to compliance and the resulting delays in certain projects and abandonment of others might be eased by additional institutional training programs and consultation on Privacy Rule issues during study design. ASCO also proposes the development of best practices documents to guide 1) creation of data repositories, 2) disclosure and use of data from such repositories, and 3) the design of survivorship and genetics studies.

Challenges in the Clinical Application of the American Society of Clinical Oncology Value Framework: A Medicare Cost-Benefit Analysis in Chronic Lymphocytic Leukemia.

PubMed

Seymour, Erlene K; Schiffer, Charles A; de Souza, Jonas A

2017-12-01

The ASCO Value Framework calculates the value of cancer therapies. Given costly novel therapeutics for chronic lymphocytic leukemia, we used the framework to compare net health benefit (NHB) and cost within Medicare of all regimens listed in the National Comprehensive Cancer Network (NCCN) guidelines. The current NCCN guidelines for chronic lymphocytic leukemia were reviewed. All referenced studies were screened, and only randomized controlled prospective trials were included. The revised ASCO Value Framework was used to calculate NHB. Medicare drug pricing was used to calculate the cost of therapies. Forty-nine studies were screened. The following observations were made: only 10 studies (20%) could be evaluated; when comparing regimens studied against the same control arm, ranking NHB scores were comparable to their preference in guidelines; NHB scores varied depending on which variables were used, and there were no clinically validated thresholds for low or high values; treatment-related deaths were not weighted in the toxicity scores; and six of the 10 studies used less potent control arms, ranked as the least-preferred NCCN-recommended regimens. The ASCO Value Framework is an important initial step to quantify value of therapies. Essential limitations include the lack of clinically relevant validated thresholds for NHB scores and lack of incorporation of grade 5 toxicities/treatment-related mortality into its methodology. To optimize its application for clinical practice, we urge investigators/sponsors to incorporate and report the required variables to calculate the NHB of regimens and encourage trials with stronger comparator arms to properly quantify the relative value of therapies.

Physician and stakeholder perceptions of conflict of interest policies in oncology.

PubMed

Lockhart, A Craig; Brose, Marcia S; Kim, Edward S; Johnson, David H; Peppercorn, Jeffrey M; Michels, Dina L; Storm, Courtney D; Schuchter, Lynn M; Rathmell, W Kimryn

2013-05-01

The landscape of managing potential conflicts of interest (COIs) has evolved substantially across many disciplines in recent years, but rarely are the issues more intertwined with financial and ethical implications than in the health care setting. Cancer care is a highly technologic arena, with numerous physician-industry interactions. The American Society of Clinical Oncology (ASCO) recognizes the role of a professional organization to facilitate management of these interactions and the need for periodic review of its COI policy (Policy). To gauge the sentiments of ASCO members and nonphysician stakeholders, two surveys were performed. The first asked ASCO members to estimate opinions of the Policy as it relates to presentation of industry-sponsored research. Respondents were classified as consumers or producers of research material based on demographic responses. A similar survey solicited opinions of nonphysician stakeholders, including patients with cancer, survivors, family members, and advocates. The ASCO survey was responded to by 1,967 members (1% of those solicited); 80% were producers, and 20% were consumers. Most respondents (93% of producers; 66% of consumers) reported familiarity with the Policy. Only a small proportion regularly evaluated COIs for presented research. Members favored increased transparency about relationships over restrictions on presentations of research. Stakeholders (n = 264) indicated that disclosure was "very important" to "extremely important" and preferred written disclosure (77%) over other methods. COI policies are an important and relevant topic among physicians and patient advocates. Methods to simplify the disclosure process, improve transparency, and facilitate responsiveness are critical for COI management.

Metastatic Pancreatic Cancer: ASCO Clinical Practice Guideline Update.

PubMed

Sohal, Davendra P S; Kennedy, Erin B; Khorana, Alok; Copur, Mehmet S; Crane, Christopher H; Garrido-Laguna, Ignacio; Krishnamurthi, Smitha; Moravek, Cassadie; O'Reilly, Eileen M; Philip, Philip A; Ramanathan, Ramesh K; Ruggiero, Joseph T; Shah, Manish A; Urba, Susan; Uronis, Hope E; Lau, Michelle W; Laheru, Daniel

2018-05-23

Purpose In 2016, ASCO published a guideline to assist in clinical decision making in metastatic pancreatic cancer for initial assessment after diagnosis, first- and second-line treatment options, palliative and supportive care, and follow-up. The purpose of this update is to incorporate new evidence related to second-line therapy for patients who have experienced disease progression or intolerable toxicity during first-line therapy. Methods ASCO convened an Expert Panel to conduct a systematic review of the literature on second-line therapy published between June 2015 and January 2018. Recommendations on other topics covered in the 2016 Metastatic Pancreatic Cancer Guideline were endorsed by the Expert Panel. Results Two new studies were found that met the inclusion criteria. Recommendations For second-line therapy, gemcitabine plus nanoparticle albumin-bound paclitaxel should be offered to patients with first-line treatment with FOLFIRINOX (leucovorin, fluorouracil, irinotecan, and oxaliplatin), an Eastern Cooperative Oncology Group performance status (ECOG PS) of 0 to 1, and a favorable comorbidity profile; fluorouracil plus nanoliposomal irinotecan can be offered to patients with first-line treatment with gemcitabine plus NAB-paclitaxel, an ECOG PS of 0 to 1, and a favorable comorbidity profile; fluorouracil plus irinotecan or fluorouracil plus oxaliplatin may be offered when there is a lack of availability of fluorouracil plus nanoliposomal irinotecan; gemcitabine or fluorouracil should be offered to patients with either an ECOG PS of 2 or a comorbidity profile that precludes other regimens. Testing select patients for mismatch repair deficiency or microsatellite instability is recommended, and pembrolizumab is recommended for patients with mismatch repair deficiency or high microsatellite instability tumors. Endorsed recommendations from the 2016 version of this guideline for computed tomography, baseline performance status and comorbidity profile, defining goals of care, first-line therapy, and palliative care are also contained within the full guideline text. Additional information is available at www.asco.org/gastrointestinal-cancer-guidelines .

Updated 2013 College of American Pathologists/American Society of Clinical Oncology (CAP/ASCO) guideline recommendations for human epidermal growth factor receptor 2 (HER2) fluorescent in situ hybridization (FISH) testing increase HER2 positive and HER2 equivocal breast cancer cases; retrospective study of HER2 FISH results of 836 invasive breast cancers.

PubMed

Singh, Kamaljeet; Tantravahi, Umadevi; Lomme, Michele M; Pasquariello, Terese; Steinhoff, Margaret; Sung, C James

2016-06-01

For dual probe HER2 FISH assay, the 2013 CAP/ASCO guideline recommendations lowered the HER2/CEP17 ratio cut off for HER2 amplification to ≥2.0 and introduced an average HER2 copy number criterion for HER2 amplification (≥6.0/cell) and HER2 equivocal categories (≥4 and <6/cell). The HER2/CEP17 equivocal category is eliminated. The aim of this study is to assess the impact of 2013 HER2 FISH testing guideline recommendations update on the assignment of HER2 status with dual probe HER2 FISH assay. Dual probe HER2 FISH assay results on breast cancers from 09/2009 to 07/2015 that underwent reflex HER2 FISH testing after equivocal HER2 (2+) immunohistochemistry (IHC) were reviewed. HER2 copy number, CEP17 signals, and HER2/CEP ratios were noted. HER2 status was assigned as HER2 negative (HER2-), HER2 equivocal (HER2e), and HER2 amplified (HER2+) by applying both 2007 and 2013 CAP/ASCO HER2 FISH guideline recommendations and results were compared. New guidelines reclassified HER2 FISH status in a significant proportion of cases (8.3 %, 69/836; p = .021). There were 22 (2.6 %) more HER2+, 17 (2.1 %) more HER2e, and 39 (4.1 %) fewer HER2- tumors. Change of HER2 status correlated significantly with ≥3 CEP17 signals (38 vs. 2 %; p < .001). The 2013 CAP/ASCO guideline recommendations for HER2 FISH testing by dual probe assay increased the HER2 amplified and HER2 equivocal tumors. Increase in HER2 equivocal tumors would potentially increase the frequency of repeat HER2 testing. Tumors with ≥3 CEP17 signals, so-called chromosome 17 polysomy, are more likely to be impacted and classified as HER2 equivocal.

ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016

PubMed Central

Dittrich, Christian; Kosty, Michael; Jezdic, Svetlana; Pyle, Doug; Berardi, Rossana; Bergh, Jonas; El-Saghir, Nagi; Lotz, Jean-Pierre; Österlund, Pia; Pavlidis, Nicholas; Purkalne, Gunta; Awada, Ahmad; Banerjee, Susana; Bhatia, Smita; Bogaerts, Jan; Buckner, Jan; Cardoso, Fatima; Casali, Paolo; Chu, Edward; Close, Julia Lee; Coiffier, Bertrand; Connolly, Roisin; Coupland, Sarah; De Petris, Luigi; De Santis, Maria; de Vries, Elisabeth G E; Dizon, Don S; Duff, Jennifer; Duska, Linda R; Eniu, Alexandru; Ernstoff, Marc; Felip, Enriqueta; Fey, Martin F; Gilbert, Jill; Girard, Nicolas; Glaudemans, Andor W J M; Gopalan, Priya K; Grothey, Axel; Hahn, Stephen M; Hanna, Diana; Herold, Christian; Herrstedt, Jørn; Homicsko, Krisztian; Jones, Dennie V; Jost, Lorenz; Keilholz, Ulrich; Khan, Saad; Kiss, Alexander; Köhne, Claus-Henning; Kunstfeld, Rainer; Lenz, Heinz-Josef; Lichtman, Stuart; Licitra, Lisa; Lion, Thomas; Litière, Saskia; Liu, Lifang; Loehrer, Patrick J; Markham, Merry Jennifer; Markman, Ben; Mayerhoefer, Marius; Meran, Johannes G; Michielin, Olivier; Moser, Elizabeth Charlotte; Mountzios, Giannis; Moynihan, Timothy; Nielsen, Torsten; Ohe, Yuichiro; Öberg, Kjell; Palumbo, Antonio; Peccatori, Fedro Alessandro; Pfeilstöcker, Michael; Raut, Chandrajit; Remick, Scot C; Robson, Mark; Rutkowski, Piotr; Salgado, Roberto; Schapira, Lidia; Schernhammer, Eva; Schlumberger, Martin; Schmoll, Hans-Joachim; Schnipper, Lowell; Sessa, Cristiana; Shapiro, Charles L; Steele, Julie; Sternberg, Cora N; Stiefel, Friedrich; Strasser, Florian; Stupp, Roger; Sullivan, Richard; Tabernero, Josep; Travado, Luzia; Verheij, Marcel; Voest, Emile; Vokes, Everett; Von Roenn, Jamie; Weber, Jeffrey S; Wildiers, Hans; Yarden, Yosef

2016-01-01

The European Society for Medical Oncology (ESMO) and the American Society of Clinical Oncology (ASCO) are publishing a new edition of the ESMO/ASCO Global Curriculum (GC) thanks to contribution of 64 ESMO-appointed and 32 ASCO-appointed authors. First published in 2004 and updated in 2010, the GC edition 2016 answers to the need for updated recommendations for the training of physicians in medical oncology by defining the standard to be fulfilled to qualify as medical oncologists. At times of internationalisation of healthcare and increased mobility of patients and physicians, the GC aims to provide state-of-the-art cancer care to all patients wherever they live. Recent progress in the field of cancer research has indeed resulted in diagnostic and therapeutic innovations such as targeted therapies as a standard therapeutic approach or personalised cancer medicine apart from the revival of immunotherapy, requiring specialised training for medical oncology trainees. Thus, several new chapters on technical contents such as molecular pathology, translational research or molecular imaging and on conceptual attitudes towards human principles like genetic counselling or survivorship have been integrated in the GC. The GC edition 2016 consists of 12 sections with 17 subsections, 44 chapters and 35 subchapters, respectively. Besides renewal in its contents, the GC underwent a principal formal change taking into consideration modern didactic principles. It is presented in a template-based format that subcategorises the detailed outcome requirements into learning objectives, awareness, knowledge and skills. Consecutive steps will be those of harmonising and implementing teaching and assessment strategies. PMID:27843641

2016 Updated American Society of Clinical Oncology/Oncology Nursing Society Chemotherapy Administration Safety Standards, Including Standards for Pediatric Oncology.

PubMed

Neuss, Michael N; Gilmore, Terry R; Belderson, Kristin M; Billett, Amy L; Conti-Kalchik, Tara; Harvey, Brittany E; Hendricks, Carolyn; LeFebvre, Kristine B; Mangu, Pamela B; McNiff, Kristen; Olsen, MiKaela; Schulmeister, Lisa; Von Gehr, Ann; Polovich, Martha

2016-12-01

Purpose To update the ASCO/Oncology Nursing Society (ONS) Chemotherapy Administration Safety Standards and to highlight standards for pediatric oncology. Methods The ASCO/ONS Chemotherapy Administration Safety Standards were first published in 2009 and updated in 2011 to include inpatient settings. A subsequent 2013 revision expanded the standards to include the safe administration and management of oral chemotherapy. A joint ASCO/ONS workshop with stakeholder participation, including that of the Association of Pediatric Hematology Oncology Nurses and American Society of Pediatric Hematology/Oncology, was held on May 12, 2015, to review the 2013 standards. An extensive literature search was subsequently conducted, and public comments on the revised draft standards were solicited. Results The updated 2016 standards presented here include clarification and expansion of existing standards to include pediatric oncology and to introduce new standards: most notably, two-person verification of chemotherapy preparation processes, administration of vinca alkaloids via minibags in facilities in which intrathecal medications are administered, and labeling of medications dispensed from the health care setting to be taken by the patient at home. The standards were reordered and renumbered to align with the sequential processes of chemotherapy prescription, preparation, and administration. Several standards were separated into their respective components for clarity and to facilitate measurement of adherence to a standard. Conclusion As oncology practice has changed, so have chemotherapy administration safety standards. Advances in technology, cancer treatment, and education and training have prompted the need for periodic review and revision of the standards. Additional information is available at http://www.asco.org/chemo-standards .

Physician and Stakeholder Perceptions of Conflict of Interest Policies in Oncology

PubMed Central

Lockhart, A. Craig; Brose, Marcia S.; Kim, Edward S.; Johnson, David H.; Peppercorn, Jeffrey M.; Michels, Dina L.; Storm, Courtney D.; Schuchter, Lynn M.; Rathmell, W. Kimryn

2013-01-01

Purpose The landscape of managing potential conflicts of interest (COIs) has evolved substantially across many disciplines in recent years, but rarely are the issues more intertwined with financial and ethical implications than in the health care setting. Cancer care is a highly technologic arena, with numerous physician-industry interactions. The American Society of Clinical Oncology (ASCO) recognizes the role of a professional organization to facilitate management of these interactions and the need for periodic review of its COI policy (Policy). Methods To gauge the sentiments of ASCO members and nonphysician stakeholders, two surveys were performed. The first asked ASCO members to estimate opinions of the Policy as it relates to presentation of industry-sponsored research. Respondents were classified as consumers or producers of research material based on demographic responses. A similar survey solicited opinions of nonphysician stakeholders, including patients with cancer, survivors, family members, and advocates. Results The ASCO survey was responded to by 1,967 members (1% of those solicited); 80% were producers, and 20% were consumers. Most respondents (93% of producers; 66% of consumers) reported familiarity with the Policy. Only a small proportion regularly evaluated COIs for presented research. Members favored increased transparency about relationships over restrictions on presentations of research. Stakeholders (n = 264) indicated that disclosure was “very important” to “extremely important” and preferred written disclosure (77%) over other methods. Conclusion COI policies are an important and relevant topic among physicians and patient advocates. Methods to simplify the disclosure process, improve transparency, and facilitate responsiveness are critical for COI management. PMID:23530092

ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016.

PubMed

Dittrich, Christian; Kosty, Michael; Jezdic, Svetlana; Pyle, Doug; Berardi, Rossana; Bergh, Jonas; El-Saghir, Nagi; Lotz, Jean-Pierre; Österlund, Pia; Pavlidis, Nicholas; Purkalne, Gunta; Awada, Ahmad; Banerjee, Susana; Bhatia, Smita; Bogaerts, Jan; Buckner, Jan; Cardoso, Fatima; Casali, Paolo; Chu, Edward; Close, Julia Lee; Coiffier, Bertrand; Connolly, Roisin; Coupland, Sarah; De Petris, Luigi; De Santis, Maria; de Vries, Elisabeth G E; Dizon, Don S; Duff, Jennifer; Duska, Linda R; Eniu, Alexandru; Ernstoff, Marc; Felip, Enriqueta; Fey, Martin F; Gilbert, Jill; Girard, Nicolas; Glaudemans, Andor W J M; Gopalan, Priya K; Grothey, Axel; Hahn, Stephen M; Hanna, Diana; Herold, Christian; Herrstedt, Jørn; Homicsko, Krisztian; Jones, Dennie V; Jost, Lorenz; Keilholz, Ulrich; Khan, Saad; Kiss, Alexander; Köhne, Claus-Henning; Kunstfeld, Rainer; Lenz, Heinz-Josef; Lichtman, Stuart; Licitra, Lisa; Lion, Thomas; Litière, Saskia; Liu, Lifang; Loehrer, Patrick J; Markham, Merry Jennifer; Markman, Ben; Mayerhoefer, Marius; Meran, Johannes G; Michielin, Olivier; Moser, Elizabeth Charlotte; Mountzios, Giannis; Moynihan, Timothy; Nielsen, Torsten; Ohe, Yuichiro; Öberg, Kjell; Palumbo, Antonio; Peccatori, Fedro Alessandro; Pfeilstöcker, Michael; Raut, Chandrajit; Remick, Scot C; Robson, Mark; Rutkowski, Piotr; Salgado, Roberto; Schapira, Lidia; Schernhammer, Eva; Schlumberger, Martin; Schmoll, Hans-Joachim; Schnipper, Lowell; Sessa, Cristiana; Shapiro, Charles L; Steele, Julie; Sternberg, Cora N; Stiefel, Friedrich; Strasser, Florian; Stupp, Roger; Sullivan, Richard; Tabernero, Josep; Travado, Luzia; Verheij, Marcel; Voest, Emile; Vokes, Everett; Von Roenn, Jamie; Weber, Jeffrey S; Wildiers, Hans; Yarden, Yosef

2016-01-01

The European Society for Medical Oncology (ESMO) and the American Society of Clinical Oncology (ASCO) are publishing a new edition of the ESMO/ASCO Global Curriculum (GC) thanks to contribution of 64 ESMO-appointed and 32 ASCO-appointed authors. First published in 2004 and updated in 2010, the GC edition 2016 answers to the need for updated recommendations for the training of physicians in medical oncology by defining the standard to be fulfilled to qualify as medical oncologists. At times of internationalisation of healthcare and increased mobility of patients and physicians, the GC aims to provide state-of-the-art cancer care to all patients wherever they live. Recent progress in the field of cancer research has indeed resulted in diagnostic and therapeutic innovations such as targeted therapies as a standard therapeutic approach or personalised cancer medicine apart from the revival of immunotherapy, requiring specialised training for medical oncology trainees. Thus, several new chapters on technical contents such as molecular pathology, translational research or molecular imaging and on conceptual attitudes towards human principles like genetic counselling or survivorship have been integrated in the GC. The GC edition 2016 consists of 12 sections with 17 subsections, 44 chapters and 35 subchapters, respectively. Besides renewal in its contents, the GC underwent a principal formal change taking into consideration modern didactic principles. It is presented in a template-based format that subcategorises the detailed outcome requirements into learning objectives, awareness, knowledge and skills. Consecutive steps will be those of harmonising and implementing teaching and assessment strategies.

Cohort profile: the Nordic Antireflux Surgery Cohort (NordASCo).

PubMed

Maret-Ouda, John; Wahlin, Karl; Artama, Miia; Brusselaers, Nele; Färkkilä, Martti; Lynge, Elsebeth; Mattsson, Fredrik; Pukkala, Eero; Romundstad, Pål; Tryggvadóttir, Laufey; Euler-Chelpin, My von; Lagergren, Jesper

2017-06-08

To describe a newly created all-Nordic cohort of patients with gastro-oesophageal reflux disease (GORD), entitled the Nordic Antireflux Surgery Cohort (NordASCo), which will be used to compare participants having undergone antireflux surgery with those who have not regarding risk of cancers, other diseases and mortality. Included were individuals with a GORD diagnosis recorded in any of the nationwide patient registries in the Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) in 1964-2014 (with various start and end years in different countries). Data regarding cancer, other diseases and mortality were retrieved from the nationwide registries for cancer, patients and causes of death, respectively. The NordASCo includes 945 153 individuals with a diagnosis of GORD. Of these, 48 433 (5.1%) have undergone primary antireflux surgery. Median age at primary antireflux surgery ranged from 47 to 52 years in the different countries. The coding practices of GORD seem to have differed between the Nordic countries. The NordASCo will initially be used to analyse the risk of developing known or potential GORD-related cancers, that is, tumours of the oesophagus, stomach, larynx, pharynx and lung, and to evaluate the mortality in the short-term and long-term perspectives. Additionally, the cohort will be used to evaluate the risk of non-malignant respiratory conditions that might be caused by aspiration of gastric contents. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

NCI-MATCH trial releases new findings

Cancer.gov

The NCI-MATCH precision medicine clinical trial has reached a milestone with the release of results from several study treatment arms. Findings from three arms were released at the 2018 ASCO annual meeting, adding to findings from one arm released in 2017.

SAMO (Sistema de Apoyo Mechanizado a la Operacion): An operational aids computer system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stormer, T.D.; Laflor, E.V.

1989-01-01

SAMO (Sistema de Apoyo Mechanizado a la Operacion) is a sensor-driven, computer-based, graphic display system designed by Westinghouse to aid the A. N. Asco operations staff during all modes of plant operations, including emergencies. The SAMO system is being implemented in the A. N. Asco plant in two phases that coincide with consecutive refueling outages for each of two nuclear units at the Asco site. Phase 1 of the SAMO system implements the following functions: (1) emergency operational aids, (2) postaccident monitoring, (3) plant graphics display, (4) high-speed transient analysis recording, (5) historical data collection, storage, and retrieval, (6) sequencemore » of events, and (7) posttrip review. During phase 2 of the SAMO project, the current plant computer will be removed and the functions now performed by the plant computer will be performed by the SAMO system. In addition, the following functions will be implemented: (1) normal and simple transients operational aid, (2) plant information graphics; and (3) real-time radiological off-site dose calculation.« less

Ibrutinib continues to influence the therapeutic landscape of chronic lymphocytic leukemia: new data presented at ASCO 2017.

PubMed

Molica, Stefano

2017-08-16

According to data presented at the 2017 American Society of Oncology (ASCO) Annual Meeting, with more than 4 years of follow-up, ibrutinib continues to provide clinical utility in chronic lymphocytic leukemia (CLL). However, treatment of CLL patients with high-risk cytogenetics features remains a challenge and the outcome of these hard-to-treat patients is dismal. At the 2017 ASCO Meeting, results of the GENUINE phase III trial showed that, by adding ublituximab, a glycoengineered, anti-CD20 type 1 monoclonal antibody, to ibrutinib, the overall response rate (ORR), complete response rate (CRR), and minimal residual disease (MRD) negativity may be improved in high-risk CLL patients. A further way to improve the results obtained with Bruton's tyrosine kinase (BTK) inhibitors is the parallel use of ibrutinib with chimeric antigen receptor (CAR) T-cell therapy. Through this investigational approach, the rate of MRD negativity was shown to be higher, implying potential eradication of CLL. These novel data indicate that ibrutinib continues to have a positive effect in CLL.

Carbonate ions and arsenic dissolution by groundwater

USGS Publications Warehouse

Kim, M.-J.; Nriagu, J.; Haack, S.

2000-01-01

Samples of Marshall Sandstone, a major source of groundwater with elevated arsenic levels in southeast Michigan, were exposed to bicarbonate ion under controlled chemical conditions. In particular, effects of pH and redox conditions on arsenic release were evaluated. The release of arsenic from the aquifer rock was strongly related to the bicarbonate concentration in the leaching solution. The results obtained suggest that the carbonation of arsenic sulfide minerals, including orpiment (As2S3) and realgar (As2S2), is an important process in leaching arsenic into groundwater under anaerobic conditions. The arseno-carbonate complexes formed, believed to be As(CO3)2-, As(CO3)(OH)2-, and AsCO3+, are stable in groundwater. The reaction of ferrous ion with the thioarsenite from carbonation process can result in the formation of arsenopyrite which is a common mineral in arsenic-rich aquifers.Samples of Marshall Sandstone, a major source of groundwater with elevated arsenic levels in southeast Michigan, were exposed to bicarbonate ion under controlled chemical conditions. In particular, effects of pH and redox conditions on arsenic release were evaluated. The release of arsenic from the aquifer rock was strongly related to the bicarbonate concentration in the leaching solution. The results obtained suggest that the carbonation of arsenic sulfide minerals, including orpiment (As2S3) and realgar (As2S2), is an important process in leaching arsenic into groundwater under anaerobic conditions. The arseno-carbonate complexes formed, believed to be As(CO3)2-, As(CO3)(OH)2-, and AsCO3+, are stable in groundwater. The reaction of ferrous ion with the thioarsenite from carbonation process can result in the formation of arsenopyrite which is a common mineral in arsenic-rich aquifers.The role of bicarbonate in leaching arsenic into groundwater was investigated by conducting batch experiments using core samples of Marshall Sandstone from southeast Michigan and different bicarbonate solutions. The effects of pH and redox conditions on As dissolution were examined. Results showed that As was not leached significantly out of the Marshall Sandstone samples after 3 d using either deionized water or groundwater, but As was leached efficiently by sodium bicarbonate, potassium bicarbonate, and ferric chloride solutions. The leaching rate with sodium bicarbonate was about 25% higher than that with potassium bicarbonate. The data indicated that bicarbonate ion was involved primarily in As dissolution and that hydroxyl radical ion did not affect As dissolution to any significant degree. The amount of As leached was dependent upon the sodium bicarbonate concentration, increasing with reaction time for each concentration. Significant As leaching was found in the extreme pH ranges of <1.9 and 8.0-10.4. The resulting arseno-carbonate complexes formed were stable in groundwater.

Untapped Potential of Observational Research to Inform Clinical Decision Making: American Society of Clinical Oncology Research Statement.

PubMed

Visvanathan, Kala; Levit, Laura A; Raghavan, Derek; Hudis, Clifford A; Wong, Sandra; Dueck, Amylou; Lyman, Gary H

2017-06-01

ASCO believes that high-quality observational studies can advance evidence-based practice for cancer care and are complementary to randomized controlled trials (RCTs). Observational studies can generate hypotheses by evaluating novel exposures or biomarkers and by revealing patterns of care and relationships that might not otherwise be discovered. Researchers can then test these hypotheses in RCTs. Observational studies can also answer or inform questions that either have not been or cannot be answered by RCTs. In addition, observational studies can be used for postmarketing surveillance of new cancer treatments, particularly in vulnerable populations. The incorporation of observational research as part of clinical decision making is consistent with the position of many leading institutions. ASCO identified five overarching recommendations to enhance the role of observational research in clinical decision making: (1) improve the quality of electronic health data available for research, (2) improve interoperability and the exchange of electronic health information, (3) ensure the use of rigorous observational research methodologies, (4) promote transparent reporting of observational research studies, and (5) protect patient privacy.

Challenges in Measuring Cost and Value in Oncology: Making It Personal.

PubMed

Yu, Peter P

2016-01-01

Oncology patients often find themselves facing an incurable disease with limited treatment options and increasing patient fragility. The importance of patient preferences and values increases in shared decision making especially when the cost of cancer care is continuing its steep rise. As our understanding of cancer systems biology increases, we are justifiably optimistic about therapeutic improvements but recognize that this has complicated the traditional Food and Drug Administration approval of drug indications based on organ-specific cancer for a particular drug. Dynamic and agile clinical guidelines that reflect a rapidly changing knowledge base for decision-making support are needed. The American Society of Clinical Oncology (ASCO) has been working on three initiatives to tackle these complex issues. The first initiative is ASCO's collaboration with other international organizations to create a framework to assess drugs for the World Health Organization's Essential Medicines List, including nongenerics. The second initiative aims to define clinically meaningful outcomes as precision medicine expands the definition of cancers, leading to increased demand for the use of targeted drugs as single agents or in combination. The third initiative is ASCO's value framework, published in 2015, focusing on patient-physician shared decision making. The framework incorporates three parameters: 1) the meaningfulness of the clinical benefit, 2) the toxicity of the treatment, and 3) the patient's financial out-of-pocket cost. ASCO is concerned about the rising cost of cancer care when the clinical complexity and the pace of change in oncology are accelerating, and it is committed to help improve patient outcomes and value in cancer care as well as to engage the broader health care community in a process of collaborative improvement. Copyright © 2016 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

American Society of Clinical Oncology Obesity Initiative: Rationale, Progress, and Future Directions.

PubMed

Ligibel, Jennifer A; Wollins, Dana

2016-12-10

Obesity is increasingly being linked to the risk of developing and dying from cancer. In recognition of the growing contribution of obesity to cancer risk and outcomes, ASCO made obesity and cancer one of its core initiatives in 2014. The goals of this initiative included raising awareness of the relationship between obesity and cancer, providing tools and resources to oncology providers and patients to help encourage conversations regarding weight management in cancer survivors, fostering a robust research agenda, and advocating for access to evidence-based weight management programs for cancer survivors. Efforts to date have included developing patient and provider toolkits focused on weight management and physical activity, publishing a policy statement outlining ASCO's initiatives in this area, and hosting a summit focused on obesity research in cancer populations. As ASCO has defined its priorities in the area of obesity and cancer, it has become increasingly clear that obesity is a problem that extends far beyond its impact on cancer risk and outcomes. Many groups, including those focused on heart disease, diabetes, and endocrinology, have been developing, testing, and implementing obesity prevention and treatment strategies for years. As ASCO moves forward with its obesity initiative, the next steps will focus on forging collaboration with groups working on obesity-related initiatives both within and outside of the field of cancer to learn from their efforts and to partner with them on efforts to increase the education of medical professionals; raising awareness in lay populations regarding the negative health consequences of obesity and effective strategies to foster weight loss; developing collaborative research initiatives; and working together to advocate for the societal changes that will be needed to combat the obesity epidemic in the United States and beyond.

Laboratory compliance with the American Society of Clinical Oncology/College of American Pathologists human epidermal growth factor receptor 2 testing guidelines: a 3-year comparison of validation procedures.

PubMed

Dyhdalo, Kathryn S; Fitzgibbons, Patrick L; Goldsmith, Jeffery D; Souers, Rhona J; Nakhleh, Raouf E

2014-07-01

The American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) published guidelines in 2007 regarding testing accuracy, interpretation, and reporting of results for HER2 studies. A 2008 survey identified areas needing improved compliance. To reassess laboratory response to those guidelines following a full accreditation cycle for an updated snapshot of laboratory practices regarding ASCO/CAP guidelines. In 2011, a survey was distributed with the HER2 immunohistochemistry (IHC) proficiency testing program identical to the 2008 survey. Of the 1150 surveys sent, 977 (85.0%) were returned, comparable to the original survey response in 2008 (757 of 907; 83.5%). New participants submitted 124 of 977 (12.7%) surveys. The median laboratory accession rate was 14,788 cases with 211 HER2 tests performed annually. Testing was validated with fluorescence in situ hybridization in 49.1% (443 of 902) of the laboratories; 26.3% (224 of 853) of the laboratories used another IHC assay. The median number of cases to validate fluorescence in situ hybridization (n = 40) and IHC (n = 27) was similar to those in 2008. Ninety-five percent concordance with fluorescence in situ hybridization was achieved by 76.5% (254 of 332) of laboratories for IHC(-) findings and 70.4% (233 of 331) for IHC(+) cases. Ninety-five percent concordance with another IHC assay was achieved by 71.1% (118 of 168) of the laboratories for negative findings and 69.6% (112 of 161) of the laboratories for positive cases. The proportion of laboratories interpreting HER2 IHC using ASCO/CAP guidelines (86.6% [798 of 921] in 2011; 83.8% [605 of 722] in 2008) remains similar. Although fixation time improvements have been made, assay validation deficiencies still exist. The results of this survey were shared within the CAP, including the Laboratory Accreditation Program and the ASCO/CAP panel revising the HER2 guidelines published in October 2013. The Laboratory Accreditation Program checklist was changed to strengthen HER2 validation practices.

Secondary Prevention of Cervical Cancer: ASCO Resource-Stratified Clinical Practice Guideline.

PubMed

Jeronimo, Jose; Castle, Philip E; Temin, Sarah; Denny, Lynette; Gupta, Vandana; Kim, Jane J; Luciani, Silvana; Murokora, Daniel; Ngoma, Twalib; Qiao, Youlin; Quinn, Michael; Sankaranarayanan, Rengaswamy; Sasieni, Peter; Schmeler, Kathleen M; Shastri, Surendra S

2017-10-01

To provide resource-stratified, evidence-based recommendations on the secondary prevention of cervical cancer globally. ASCO convened a multidisciplinary, multinational panel of oncology, primary care, epidemiology, health economic, cancer control, public health, and patient advocacy experts to produce recommendations reflecting four resource-tiered settings. A review of existing guidelines, a formal consensus-based process, and a modified ADAPTE process to adapt existing guidelines were conducted. Other experts participated in formal consensus. Seven existing guidelines were identified and reviewed, and adapted recommendations form the evidence base. Four systematic reviews plus cost-effectiveness analyses provided indirect evidence to inform consensus, which resulted in ≥ 75% agreement. Human papillomavirus (HPV) DNA testing is recommended in all resource settings; visual inspection with acetic acid may be used in basic settings. Recommended age ranges and frequencies by setting are as follows: maximal: ages 25 to 65, every 5 years; enhanced: ages 30 to 65, if two consecutive negative tests at 5-year intervals, then every 10 years; limited: ages 30 to 49, every 10 years; and basic: ages 30 to 49, one to three times per lifetime. For basic settings, visual assessment is recommended as triage; in other settings, genotyping and/or cytology are recommended. For basic settings, treatment is recommended if abnormal triage results are present; in other settings, colposcopy is recommended for abnormal triage results. For basic settings, treatment options are cryotherapy or loop electrosurgical excision procedure; for other settings, loop electrosurgical excision procedure (or ablation) is recommended. Twelve-month post-treatment follow-up is recommended in all settings. Women who are HIV positive should be screened with HPV testing after diagnosis and screened twice as many times per lifetime as the general population. Screening is recommended at 6 weeks postpartum in basic settings; in other settings, screening is recommended at 6 months. In basic settings without mass screening, infrastructure for HPV testing, diagnosis, and treatment should be developed.Additional information can be found at www.asco.org/rs-cervical-cancer-secondary-prev-guideline and www.asco.org/guidelineswiki.It is the view of of ASCO that health care providers and health care system decision makers should be guided by the recommendations for the highest stratum of resources available. The guideline is intended to complement, but not replace, local guidelines.

Secondary Prevention of Cervical Cancer: ASCO Resource-Stratified Clinical Practice Guideline

PubMed Central

Jeronimo, Jose; Castle, Philip E.; Temin, Sarah; Denny, Lynette; Gupta, Vandana; Kim, Jane J.; Luciani, Silvana; Murokora, Daniel; Ngoma, Twalib; Qiao, Youlin; Quinn, Michael; Sankaranarayanan, Rengaswamy; Sasieni, Peter; Schmeler, Kathleen M.; Shastri, Surendra S.

2017-01-01

Purpose To provide resource-stratified, evidence-based recommendations on the secondary prevention of cervical cancer globally. Methods ASCO convened a multidisciplinary, multinational panel of oncology, primary care, epidemiology, health economic, cancer control, public health, and patient advocacy experts to produce recommendations reflecting four resource-tiered settings. A review of existing guidelines, a formal consensus-based process, and a modified ADAPTE process to adapt existing guidelines were conducted. Other experts participated in formal consensus. Results Seven existing guidelines were identified and reviewed, and adapted recommendations form the evidence base. Four systematic reviews plus cost-effectiveness analyses provided indirect evidence to inform consensus, which resulted in ≥ 75% agreement. Recommendations Human papillomavirus (HPV) DNA testing is recommended in all resource settings; visual inspection with acetic acid may be used in basic settings. Recommended age ranges and frequencies by setting are as follows: maximal: ages 25 to 65, every 5 years; enhanced: ages 30 to 65, if two consecutive negative tests at 5-year intervals, then every 10 years; limited: ages 30 to 49, every 10 years; and basic: ages 30 to 49, one to three times per lifetime. For basic settings, visual assessment is recommended as triage; in other settings, genotyping and/or cytology are recommended. For basic settings, treatment is recommended if abnormal triage results are present; in other settings, colposcopy is recommended for abnormal triage results. For basic settings, treatment options are cryotherapy or loop electrosurgical excision procedure; for other settings, loop electrosurgical excision procedure (or ablation) is recommended. Twelve-month post-treatment follow-up is recommended in all settings. Women who are HIV positive should be screened with HPV testing after diagnosis and screened twice as many times per lifetime as the general population. Screening is recommended at 6 weeks postpartum in basic settings; in other settings, screening is recommended at 6 months. In basic settings without mass screening, infrastructure for HPV testing, diagnosis, and treatment should be developed. Additional information can be found at www.asco.org/rs-cervical-cancer-secondary-prev-guideline and www.asco.org/guidelineswiki. It is the view of of ASCO that health care providers and health care system decision makers should be guided by the recommendations for the highest stratum of resources available. The guideline is intended to complement, but not replace, local guidelines. PMID:29094101

Reconnaissance study of late quaternary faulting along cerro GoDen fault zone, western Puerto Rico

USGS Publications Warehouse

Mann, P.; Prentice, C.S.; Hippolyte, J.-C.; Grindlay, N.R.; Abrams, L.J.; Lao-Davila, D.

2005-01-01

The Cerro GoDen fault zone is associated with a curvilinear, continuous, and prominent topographic lineament in western Puerto Rico. The fault varies in strike from northwest to west. In its westernmost section, the fault is ???500 m south of an abrupt, curvilinear mountain front separating the 270- to 361-m-high La CaDena De San Francisco range from the Rio A??asco alluvial valley. The Quaternary fault of the A??asco Valley is in alignment with the bedrock fault mapped by D. McIntyre (1971) in the Central La Plata quadrangle sheet east of A??asco Valley. Previous workers have postulated that the Cerro GoDen fault zone continues southeast from the A??asco Valley and merges with the Great Southern Puerto Rico fault zone of south-central Puerto Rico. West of the A??asco Valley, the fault continues offshore into the Mona Passage (Caribbean Sea) where it is characterized by offsets of seafloor sediments estimated to be of late Quaternary age. Using both 1:18,500 scale air photographs taken in 1936 and 1:40,000 scale photographs taken by the U.S. Department of Agriculture in 1986, we iDentified geomorphic features suggestive of Quaternary fault movement in the A??asco Valley, including aligned and Deflected drainages, apparently offset terrace risers, and mountain-facing scarps. Many of these features suggest right-lateral displacement. Mapping of Paleogene bedrock units in the uplifted La CaDena range adjacent to the Cerro GoDen fault zone reveals the main tectonic events that have culminated in late Quaternary normal-oblique displacement across the Cerro GoDen fault. Cretaceous to Eocene rocks of the La CaDena range exhibit large folds with wavelengths of several kms. The orientation of folds and analysis of fault striations within the folds indicate that the folds formed by northeast-southwest shorTening in present-day geographic coordinates. The age of Deformation is well constrained as late Eocene-early Oligocene by an angular unconformity separating folDed, Deep-marine middle Eocene rocks from transgressive, shallow-marine rocks of middle-upper Oligocene age. Rocks of middle Oligocene-early Pliocene age above unconformity are gently folDed about the roughly east-west-trending Puerto Rico-Virgin Islands arch, which is well expressed in the geomorphology of western Puerto Rico. Arching appears ongoing because onshore and offshore late Quaternary oblique-slip faults closely parallel the complexly Deformed crest of the arch and appear to be related to exTensional strains focused in the crest of the arch. We estimate ???4 km of vertical throw on the Cerro GoDen fault based on the position of the carbonate cap north of the fault in the La CaDena De San Francisco and its position south of the fault inferred from seismic reflection data in Mayaguez Bay. Based on these observations, our interpretation of the kinematics and history of the Cerro GoDen fault zone incluDes two major phases of motion: (1) Eocene northeast-southwest shorTening possibly accompanied by left-lateral shearing as Determined by previous workers on the Great Southern Puerto Rico fault zone; and (2) post-early Pliocene regional arching of Puerto Rico accompanied by normal offset and right-lateral shear along faults flanking the crest of the arch. The second phase of Deformation accompanied east-west opening of the Mona rift and is inferred to continue to the present day. ?? 2005 Geological Society of America.

A Survey of Optometry Graduates to Determine Practice Patterns.

ERIC Educational Resources Information Center

Bleimann, Robert L.; Smith, Lee W.

1984-01-01

A summary of a study of optometry graduates conducted by the Association of Schools and Colleges of Optometry (ASCO) is provided. The data covered aspects of recently graduated O.D.s' experience in obtaining a state license, becoming established in practice, and their practice characteristics. (Author/MLW)

Recommendations on disease management for patients with advanced human epidermal growth factor receptor 2-positive breast cancer and brain metastases: American Society of Clinical Oncology clinical practice guideline.

PubMed

Ramakrishna, Naren; Temin, Sarah; Chandarlapaty, Sarat; Crews, Jennie R; Davidson, Nancy E; Esteva, Francisco J; Giordano, Sharon H; Gonzalez-Angulo, Ana M; Kirshner, Jeffrey J; Krop, Ian; Levinson, Jennifer; Modi, Shanu; Patt, Debra A; Perez, Edith A; Perlmutter, Jane; Winer, Eric P; Lin, Nancy U

2014-07-01

To provide formal expert consensus-based recommendations to practicing oncologists and others on the management of brain metastases for patients with human epidermal growth factor receptor 2 (HER2) -positive advanced breast cancer. The American Society of Clinical Oncology (ASCO) convened a panel of medical oncology, radiation oncology, guideline implementation, and advocacy experts and conducted a systematic review of the literature. When that failed to yield sufficiently strong quality evidence, the Expert Panel undertook a formal expert consensus-based process to produce these recommendations. ASCO used a modified Delphi process. The panel members drafted recommendations, and a group of other experts joined them for two rounds of formal ratings of the recommendations. No studies or existing guidelines met the systematic review criteria; therefore, ASCO conducted a formal expert consensus-based process. Patients with brain metastases should receive appropriate local therapy and systemic therapy, if indicated. Local therapies include surgery, whole-brain radiotherapy, and stereotactic radiosurgery. Treatments depend on factors such as patient prognosis, presence of symptoms, resectability, number and size of metastases, prior therapy, and whether metastases are diffuse. Other options include systemic therapy, best supportive care, enrollment onto a clinical trial, and/or palliative care. Clinicians should not perform routine magnetic resonance imaging (MRI) to screen for brain metastases, but rather should have a low threshold for MRI of the brain because of the high incidence of brain metastases among patients with HER2-positive advanced breast cancer. © 2014 by American Society of Clinical Oncology.

Challenges in comprehensive management of spinal cord injury in India and in the Asian Spinal Cord network region: findings of a survey of experts, patients and consumers.

PubMed

Chhabra, H S; Sharma, S; Arora, M

2018-01-01

Online survey. To understand the prevailing scenario of the comprehensive management of spinal cord injuries (SCI) in India and in the Asian Spinal Cord Network (ASCoN) region, especially with a view to document the challenges faced and its impact. Indian Spinal Injuries Centre. A questionnaire was designed which covered various aspects of SCI management. Patients, consumers (spinal injured patients discharged since at least 1 year) and experts in SCI management from different parts of India and the ASCoN region were approached to complete the survey. Sixty patients, 66 consumers and 34 experts completed the survey. Difference of opinion was noticed among the three groups. Disposable Nelaton catheters were used by 57% consumers and 47% patients. For reusable catheter, 31% experts recommended processing with soap and running water and 45% recommended clean cotton cloth bag for storage. Pre-hospital care and community inclusion pose the biggest challenges in management of SCI. More than 75% of SCI faced problems of access and mobility in the community. Awareness about SCI, illiteracy and inadequate patient education are the most important factors hindering pre- and in-hospital care. Inadequate physical as well as vocational rehabilitation and financial barriers are thought to be the major factors hindering integration of spinal injured into mainstream society. Strong family support helped in rehabilitation. Our study brought out that SCI in India and ASCoN region face numerous challenges that affect access to almost all aspects of comprehensive management of SCI.

Literature searching for clinical and cost-effectiveness studies used in health technology assessment reports carried out for the National Institute for Clinical Excellence appraisal system.

PubMed

Royle, P; Waugh, N

2003-01-01

To contribute to making searching for Technology Assessment Reports (TARs) more cost-effective by suggesting an optimum literature retrieval strategy. A sample of 20 recent TARs. All sources used to search for clinical and cost-effectiveness studies were recorded. In addition, all studies that were included in the clinical and cost-effectiveness sections of the TARs were identified, and their characteristics recorded, including author, journal, year, study design, study size and quality score. Each was also classified by publication type, and then checked to see whether it was indexed in the following databases: MEDLINE, EMBASE, and then either the Cochrane Controlled Trials Register (CCTR) for clinical effectiveness studies or the NHS Economic Evaluation Database (NHS EED) for the cost-effectiveness studies. Any study not found in at least one of these databases was checked to see whether it was indexed in the Science Citation Index (SCI) and BIOSIS, and the American Society of Clinical Oncology (ASCO) Online if a cancer review. Any studies still not found were checked to see whether they were in a number of additional databases. The median number of sources searched per TAR was 20, and the range was from 13 to 33 sources. Six sources (CCTR, DARE, EMBASE, MEDLINE, NHS EED and sponsor/industry submissions to National Institute for Clinical Excellence) were used in all reviews. After searching the MEDLINE, EMBASE and NHS EED databases, 87.3% of the clinical effectiveness studies and 94.8% of the cost-effectiveness studies were found, rising to 98.2% when SCI, BIOSIS and ASCO Online and 97.9% when SCI and ASCO Online, respectively, were added. The median number of sources searched for the 14 TARs that included an economic model was 9.0 per TAR. A sensitive search filter for identifying non-randomised controlled trials (RCT), constructed for MEDLINE and using the search terms from the bibliographic records in the included studies, retrieved only 85% of the known sample. Therefore, it is recommended that when searching for non-RCT studies a search is done for the intervention alone, and records are then scanned manually for those that look relevant. Searching additional databases beyond the Cochrane Library (which includes CCTR, NHS EED and the HTA database), MEDLINE, EMBASE and SCI, plus BIOSIS limited to meeting abstracts only, was seldom found to be effective in retrieving additional studies for inclusion in the clinical and cost-effectiveness sections of TARs (apart from reviews of cancer therapies, where a search of the ASCO database is recommended). A more selective approach to database searching would suffice in most cases and would save resources, thereby making the TAR process more efficient. However, searching non-database sources (including submissions from manufacturers, recent meeting abstracts, contact with experts and checking reference lists) does appear to be a productive way of identifying further studies.

Cancer-related fatigue: appraising evidence-based guidelines for screening, assessment and management.

PubMed

Pearson, Elizabeth J M; Morris, Meg E; McKinstry, Carol E

2016-09-01

There is inconsistent management of cancer-related fatigue (CRF) by health professionals worldwide. This research aims to identify the most appropriate guidelines for the management of cancer-related fatigue. A systematic search of international literature identified evidence-based clinical practice guidelines for CRF. Four reviewers independently appraised the highest quality guidelines using the AGREE-II instrument and National Heath and Medical Research Council (NHMRC) guideline standards. Five guidelines met the inclusion criteria. Of these, the 2015 Canadian Association of Psychosocial Oncology (CAPO) CRF guidelines and the 2014 American Society of Clinical Oncology (ASCO) fatigue guidelines for cancer survivors were selected for in-depth appraisal. The CAPO guideline scored higher than the ASCO for five domains of the AGREE-II. For one domain, the differences were statistically significant (p ≤ 0.05). The CAPO guideline met 37 of 47 NHMRC mandatory guideline standards and the ASCO guideline met 20. The difference in the proportion of standards met was statistically significant for one domain (p ≤ 0.05). Both guidelines had low scores for applicability and implementation. Currently, the CAPO guideline for cancer-related fatigue has the strongest evidence for use. To enhance implementation, further strategies for guideline dissemination and application are needed.

Management and Care of Women With Invasive Cervical Cancer: American Society of Clinical Oncology Resource-Stratified Clinical Practice Guideline.

PubMed

Chuang, Linus T; Temin, Sarah; Camacho, Rolando; Dueñas-Gonzalez, Alfonso; Feldman, Sarah; Gultekin, Murat; Gupta, Vandana; Horton, Susan; Jacob, Graciela; Kidd, Elizabeth A; Lishimpi, Kennedy; Nakisige, Carolyn; Nam, Joo-Hyun; Ngan, Hextan Yuen Sheung; Small, William; Thomas, Gillian; Berek, Jonathan S

2016-10-01

To provide evidence-based, resource-stratified global recommendations to clinicians and policymakers on the management and palliative care of women diagnosed with invasive cervical cancer. ASCO convened a multidisciplinary, multinational panel of cancer control, medical and radiation oncology, health economic, obstetric and gynecologic, and palliative care experts to produce recommendations reflecting resource-tiered settings. A systematic review of literature from 1966 to 2015 failed to yield sufficiently strong quality evidence to support basic- and limited-resource setting recommendations; a formal consensus-based process was used to develop recommendations. A modified ADAPTE process was also used to adapt recommendations from existing guidelines. Five existing sets of guidelines were identified and reviewed, and adapted recommendations form the evidence base. Eight systematic reviews, along with cost-effectiveness analyses, provided indirect evidence to inform the consensus process, which resulted in agreement of 75% or greater. Clinicians and planners should strive to provide access to the most effective evidence-based antitumor and palliative care interventions. If a woman cannot access these within her own or neighboring country or region, she may need to be treated with lower-tier modalities, depending on capacity and resources for surgery, chemotherapy, radiation therapy, and supportive and palliative care. For women with early-stage cervical cancer in basic settings, cone biopsy or extrafascial hysterectomy may be performed. Fertility-sparing procedures or modified radical or radical hysterectomy may be additional options in nonbasic settings. Combinations of surgery, chemotherapy, and radiation therapy (including brachytherapy) should be used for women with stage IB to IVA disease, depending on available resources. Pain control is a vital component of palliative care. Additional information is available at www.asco.org/rs-cervical-cancer-treatment-guideline and www.asco.org/guidelineswiki. It is the view of ASCO that health care providers and health care system decision makers should be guided by the recommendations for the highest stratum of resources available. The guideline is intended to complement but not replace local guidelines.

HER2 Gene Amplification Testing by Fluorescent In Situ Hybridization (FISH): Comparison of the ASCO-College of American Pathologists Guidelines With FISH Scores Used for Enrollment in Breast Cancer International Research Group Clinical Trials

PubMed Central

Sauter, Guido; Buyse, Marc; Fourmanoir, Hélène; Quinaux, Emmanuel; Tsao-Wei, Denice D.; Eiermann, Wolfgang; Robert, Nicholas; Pienkowski, Tadeusz; Crown, John; Martin, Miguel; Valero, Vicente; Mackey, John R.; Bee, Valerie; Ma, Yanling; Villalobos, Ivonne; Campeau, Anaamika; Mirlacher, Martina; Lindsay, Mary-Ann; Slamon, Dennis J.

2016-01-01

Purpose ASCO and the College of American Pathologists (ASCO-CAP) recently recommended further changes to the evaluation of human epidermal growth factor receptor 2 gene (HER2) amplification by fluorescent in situ hybridization (FISH). We retrospectively assessed the impact of these new guidelines by using annotated Breast Cancer International Research Group (BCIRG) -005, BCIRG-006, and BCIRG-007 clinical trials data for which we have detailed outcomes. Patients and Methods The HER2 FISH status of BCIRG-005/006/007 patients with breast cancers was re-evaluated according to current ASCO-CAP guidelines, which designates five different groups according to HER2 FISH ratio and average HER2 gene copy number per tumor cell: group 1 (in situ hybridization [ISH]–positive): HER2-to-chromosome 17 centromere ratio ≥ 2.0, average HER2 copies ≥ 4.0; group 2 (ISH-positive): ratio ≥ 2.0, copies < 4.0; group 3 (ISH-positive): ratio < 2.0, copies ≥ 6.0; group 4 (ISH-equivocal): ratio < 2.0, copies ≥ 4.0 and < 6.0; and group 5 (ISH-negative): ratio < 2.0, copies < 4.0. We assessed correlations with HER2 protein, clinical outcomes by disease-free survival (DFS) and overall survival (OS) and benefit from trastuzumab therapy (hazard ratio [HR]). Results Among 10,468 patients with breast cancers who were successfully screened for trial entry, 40.8% were in ASCO-CAP ISH group 1, 0.7% in group 2; 0.5% in group 3, 4.1% in group 4, and 53.9% in group 5. Distributions were similar in screened compared with accrued subpopulations. Among accrued patients, FISH group 1 breast cancers were strongly correlated with immunohistochemistry 3+ status (P < .0001), whereas groups 2, 3, 4, and 5 were not; however, groups 2, 4 and, 5 were strongly correlated with immunohistochemistry 0/1+ status (all P < .0001), whereas group 3 was not. Among patients accrued to BCIRG-005, group 4 was not associated with significantly worse DFS or OS compared with group 5. Among patients accrued to BCIRG-006, only group 1 showed a significant benefit from trastuzumab therapy (DFS HR, 0.71; 95% CI, 0.60 to 0.83; P < .0001; OS HR, 0.69; 95% CI, 0.55 to 0.85; P = .0006), whereas group 2 did not. Conclusion Our findings support the original categorizations of HER2 by FISH status in BCIRG/Translational Research in Oncology trials. PMID:27573653

HER2 Gene Amplification Testing by Fluorescent In Situ Hybridization (FISH): Comparison of the ASCO-College of American Pathologists Guidelines With FISH Scores Used for Enrollment in Breast Cancer International Research Group Clinical Trials.

PubMed

Press, Michael F; Sauter, Guido; Buyse, Marc; Fourmanoir, Hélène; Quinaux, Emmanuel; Tsao-Wei, Denice D; Eiermann, Wolfgang; Robert, Nicholas; Pienkowski, Tadeusz; Crown, John; Martin, Miguel; Valero, Vicente; Mackey, John R; Bee, Valerie; Ma, Yanling; Villalobos, Ivonne; Campeau, Anaamika; Mirlacher, Martina; Lindsay, Mary-Ann; Slamon, Dennis J

2016-10-10

Purpose ASCO and the College of American Pathologists (ASCO-CAP) recently recommended further changes to the evaluation of human epidermal growth factor receptor 2 gene (HER2) amplification by fluorescent in situ hybridization (FISH). We retrospectively assessed the impact of these new guidelines by using annotated Breast Cancer International Research Group (BCIRG) -005, BCIRG-006, and BCIRG-007 clinical trials data for which we have detailed outcomes. Patients and Methods The HER2 FISH status of BCIRG-005/006/007 patients with breast cancers was re-evaluated according to current ASCO-CAP guidelines, which designates five different groups according to HER2 FISH ratio and average HER2 gene copy number per tumor cell: group 1 (in situ hybridization [ISH]-positive): HER2-to-chromosome 17 centromere ratio ≥ 2.0, average HER2 copies ≥ 4.0; group 2 (ISH-positive): ratio ≥ 2.0, copies < 4.0; group 3 (ISH-positive): ratio < 2.0, copies ≥ 6.0; group 4 (ISH-equivocal): ratio < 2.0, copies ≥ 4.0 and < 6.0; and group 5 (ISH-negative): ratio < 2.0, copies < 4.0. We assessed correlations with HER2 protein, clinical outcomes by disease-free survival (DFS) and overall survival (OS) and benefit from trastuzumab therapy (hazard ratio [HR]). Results Among 10,468 patients with breast cancers who were successfully screened for trial entry, 40.8% were in ASCO-CAP ISH group 1, 0.7% in group 2; 0.5% in group 3, 4.1% in group 4, and 53.9% in group 5. Distributions were similar in screened compared with accrued subpopulations. Among accrued patients, FISH group 1 breast cancers were strongly correlated with immunohistochemistry 3+ status (P < .0001), whereas groups 2, 3, 4, and 5 were not; however, groups 2, 4 and, 5 were strongly correlated with immunohistochemistry 0/1+ status (all P < .0001), whereas group 3 was not. Among patients accrued to BCIRG-005, group 4 was not associated with significantly worse DFS or OS compared with group 5. Among patients accrued to BCIRG-006, only group 1 showed a significant benefit from trastuzumab therapy (DFS HR, 0.71; 95% CI, 0.60 to 0.83; P < .0001; OS HR, 0.69; 95% CI, 0.55 to 0.85; P = .0006), whereas group 2 did not. Conclusion Our findings support the original categorizations of HER2 by FISH status in BCIRG/Translational Research in Oncology trials.

Integrated information systems for electronic chemotherapy medication administration.

PubMed

Levy, Mia A; Giuse, Dario A; Eck, Carol; Holder, Gwen; Lippard, Giles; Cartwright, Julia; Rudge, Nancy K

2011-07-01

Chemotherapy administration is a highly complex and distributed task in both the inpatient and outpatient infusion center settings. The American Society of Clinical Oncology and the Oncology Nursing Society (ASCO/ONS) have developed standards that specify procedures and documentation requirements for safe chemotherapy administration. Yet paper-based approaches to medication administration have several disadvantages and do not provide any decision support for patient safety checks. Electronic medication administration that includes bar coding technology may provide additional safety checks, enable consistent documentation structure, and have additional downstream benefits. We describe the specialized configuration of clinical informatics systems for electronic chemotherapy medication administration. The system integrates the patient registration system, the inpatient order entry system, the pharmacy information system, the nursing documentation system, and the electronic health record. We describe the process of deploying this infrastructure in the adult and pediatric inpatient oncology, hematology, and bone marrow transplant wards at Vanderbilt University Medical Center. We have successfully adapted the system for the oncology-specific documentation requirements detailed in the ASCO/ONS guidelines for chemotherapy administration. However, several limitations remain with regard to recording the day of treatment and dose number. Overall, the configured systems facilitate compliance with the ASCO/ONS guidelines and improve the consistency of documentation and multidisciplinary team communication. Our success has prompted us to deploy this infrastructure in our outpatient chemotherapy infusion centers, a process that is currently underway and that will require a few unique considerations.

Clinical cancer advances 2011: Annual Report on Progress Against Cancer from the American Society of Clinical Oncology.

PubMed

Vogelzang, Nicholas J; Benowitz, Steven I; Adams, Sylvia; Aghajanian, Carol; Chang, Susan Marina; Dreyer, Zoann Eckert; Janne, Pasi A; Ko, Andrew H; Masters, Greg A; Odenike, Olatoyosi; Patel, Jyoti D; Roth, Bruce J; Samlowski, Wolfram E; Seidman, Andrew D; Tap, William D; Temel, Jennifer S; Von Roenn, Jamie H; Kris, Mark G

2012-01-01

A message from ASCO'S President. It has been forty years since President Richard Nixon signed the National Cancer Act of 1971, which many view as the nation's declaration of the "War on Cancer." The bill has led to major investments in cancer research and significant increases in cancer survival. Today, two-thirds of patients survive at least five years after being diagnosed with cancer compared with just half of all diagnosed patients surviving five years after diagnosis in 1975. The research advances detailed in this year's Clinical Cancer Advances demonstrate that improvements in cancer screening, treatment, and prevention save and improve lives. But although much progress has been made, cancer remains one of the world's most serious health problems. In the United States, the disease is expected to become the nation's leading cause of death in the years ahead as our population ages. I believe we can accelerate the pace of progress, provided that everyone involved in cancer care works together to achieve this goal. It is this viewpoint that has shaped the theme for my presidential term: Collaborating to Conquer Cancer. In practice, this means that physicians and researchers must learn from every patient's experience, ensure greater collaboration between members of a patient's medical team, and involve more patients in the search for cures through clinical trials. Cancer advocates, insurers, and government agencies also have important roles to play. Today, we have an incredible opportunity to improve the quality of cancer care by drawing lessons from the real-world experiences of patients. The American Society of Clinical Oncology (ASCO) is taking the lead in this area, in part through innovative use of health information technology. In addition to our existing quality initiatives, ASCO is working with partners to develop a comprehensive rapid-learning system for cancer care. When complete, this system will provide physicians with personalized, real-time information that can inform the care of every patient with cancer as well as connect patients with their entire medical teams. The rapid learning system will form a continuous cycle of learning: securely capturing data from every patient at the point of care, drawing on evidence-based guidelines, and evaluating quality of care against those standards and the outcomes of other patients. Clinical trials are another area in which collaboration is critical. Increasing clinical trial participation will require commitment across the cancer community from physicians, patients, insurers, hospitals, and industry. A 2010 report by the Institute of Medicine described challenges to participation in trials by both physicians and patients and provided recommendations for revitalizing clinical trials conducted through the National Cancer Institute's Cooperative Group Program. ASCO has pledged its support for the full implementation of these recommendations. More broadly, ASCO recently outlined a bold vision for translational and clinical cancer research for the next decade and made recommendations to achieve that vision. Accelerating Progress Against Cancer: ASCO's Blueprint for Transforming Clinical and Translational Research, released in November, calls for a research system that takes full advantage of today's scientific and technologic opportunities and sets a high-level agenda for policy makers, regulators, and advocates. Cancer research has transformed cancer care in the past forty years, and this year's Clinical Cancer Advances illustrates how far we have come in the past year alone. We now have a tremendous opportunity to use today's knowledge and collaborate across all facets of cancer care to conquer this deadly disease. Michael P. Link, MD President American Society of Clinical Oncology.

Clinical Cancer Advances 2018: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology.

PubMed

Heymach, John; Krilov, Lada; Alberg, Anthony; Baxter, Nancy; Chang, Susan Marina; Corcoran, Ryan; Dale, William; DeMichele, Angela; Magid Diefenbach, Catherine S; Dreicer, Robert; Epstein, Andrew S; Gillison, Maura L; Graham, David L; Jones, Joshua; Ko, Andrew H; Lopez, Ana Maria; Maki, Robert G; Rodriguez-Galindo, Carlos; Schilsky, Richard L; Sznol, Mario; Westin, Shannon Neville; Burstein, Harold

2018-04-01

A MESSAGE FROM ASCO'S PRESIDENT I remember when ASCO first conceived of publishing an annual report on the most transformative research occurring in cancer care. Thirteen reports later, the progress we have chronicled is remarkable, and this year is no different. The research featured in ASCO's Clinical Cancer Advances 2018 report underscores the impressive gains in our understanding of cancer and in our ability to tailor treatments to tumors' genetic makeup. The ASCO 2018 Advance of the Year, adoptive cell immunotherapy, allows clinicians to genetically reprogram patients' own immune cells to find and attack cancer cells throughout the body. Chimeric antigen receptor (CAR) T-cell therapy-a type of adoptive cell immunotherapy-has led to remarkable results in young patients with acute lymphoblastic leukemia (ALL) and in adults with lymphoma and multiple myeloma. Researchers are also exploring this approach in other types of cancer. This advance would not be possible without robust federal investment in cancer research. The first clinical trial of CAR T-cell therapy in children with ALL was funded, in part, by grants from the National Cancer Institute (NCI), and researchers at the NCI Center for Cancer Research were the first to report on possible CAR T-cell therapy for multiple myeloma. These discoveries follow decades of prior research on immunology and cancer biology, much of which was supported by federal dollars. In fact, many advances that are highlighted in the 2018 Clinical Cancer Advances report were made possible thanks to our nation's support for biomedical research. Funding from the US National Institutes of Health and the NCI helps researchers pursue critical patient care questions and addresses vital, unmet needs that private industry has little incentive to take on. Federally supported cancer research generates the biomedical innovations that fuel the development and availability of new and improved treatments for patients. We need sustained federal research investment to accelerate the discovery of the next generation of cancer treatments. Another major trend in this year's report is progress in precision medicine approaches to treat cancer. Although precision medicine offers promise to people with cancer and their families, that promise is only as good as our ability to make these treatments available to all patients. My presidential theme, "Delivering Discoveries: Expanding the Reach of Precision Medicine," focuses on tackling this formidable challenge so that new targeted therapies are accessible to anyone who faces a cancer diagnosis. By improving access to high-quality care, harnessing big data on patient outcomes from across the globe, and pursuing innovative clinical trials, I am optimistic that we will speed the delivery of these most promising treatments to more patients. Sincerely, Bruce E. Johnson, FASCO ASCO President, 2017 to 2018.

Electronic nicotine delivery systems: a policy statement from the American Association for Cancer Research and the American Society of Clinical Oncology.

PubMed

Brandon, Thomas H; Goniewicz, Maciej L; Hanna, Nasser H; Hatsukami, Dorothy K; Herbst, Roy S; Hobin, Jennifer A; Ostroff, Jamie S; Shields, Peter G; Toll, Benjamin A; Tyne, Courtney A; Viswanath, Kasisomayajula; Warren, Graham W

2015-03-10

Combustible tobacco use remains the number-one preventable cause of disease, disability, and death in the United States. Electronic nicotine delivery systems (ENDS), which include electronic cigarettes, are devices capable of delivering nicotine in an aerosolized form. ENDS use by both adults and youth has increased rapidly, and some have advocated these products could serve as harm-reduction devices and smoking cessation aids. ENDS may be beneficial if they reduce smoking rates or prevent or reduce the known adverse health effects of smoking. However, ENDS may also be harmful, particularly to youth, if they increase the likelihood that nonsmokers or former smokers will use combustible tobacco products or if they discourage smokers from quitting. The American Association for Cancer Research (AACR) and the American Society of Clinical Oncology (ASCO) recognize the potential ENDS have to alter patterns of tobacco use and affect the health of the public; however, definitive data are lacking. The AACR and ASCO recommend additional research on these devices, including assessing the health impacts of ENDS, understanding patterns of ENDS use, and determining what role ENDS have in cessation. Key policy recommendations include supporting federal, state, and local regulation of ENDS; requiring manufacturers to register with the US Food and Drug Administration and report all product ingredients, requiring childproof caps on ENDS liquids, and including warning labels on products and their advertisements; prohibiting youth-oriented marketing and sales; prohibiting child-friendly ENDS flavors; and prohibiting ENDS use in places where cigarette smoking is prohibited. This policy statement was developed by a joint writing group composed of members from the Tobacco and Cancer Subcommittee of the American Association for Cancer Research (AACR) Science Policy and Government Affairs (SPGA) Committee and American Society of Clinical Oncology (ASCO) Tobacco Cessation and Control Subcommittee of the Cancer Prevention Committee (CaPC). The statement was reviewed by both parent committees (ie, the AACR SPGA Committee and the ASCO CaPC) and was approved by the AACR Boards of Directors on August 6, 2014, and the ASCO Executive Committee on September 18, 2014. This policy statement was published jointly by invitation and consent in both Clinical Cancer Research and Journal of Clinical Oncology. Copyright 2015 American Association for Cancer Research and American Society of Clinical Oncology. All rights reserved. No part of this document may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or storage in any information storage and retrieval system, without written permission by the American Association for Cancer Research and the American Society of Clinical Oncology. © 2015 by American Association for Cancer Research and American Society of Clinical Oncology.

Familial Adenomatous Polyposis

MedlinePlus

... these screening recommendations at the Journal of Clinical Oncology . Please note this link takes you to another ... and caregivers, from the American Society of Clinical Oncology (ASCO), the voice of the world’s cancer physicians ...

When your child's treatment stops working

MedlinePlus

... animals your child loves. Alternative Names End of life care - children; Palliative care - children; Advance care planning - children References American Society of Clinical Oncology (ASCO). Caring for a Terminally Ill Child: A ...

Management and Care of Women With Invasive Cervical Cancer: American Society of Clinical Oncology Resource-Stratified Clinical Practice Guideline

PubMed Central

Chuang, Linus T.; Temin, Sarah; Camacho, Rolando; Dueñas-Gonzalez, Alfonso; Feldman, Sarah; Gultekin, Murat; Gupta, Vandana; Horton, Susan; Jacob, Graciela; Kidd, Elizabeth A.; Lishimpi, Kennedy; Nakisige, Carolyn; Nam, Joo-Hyun; Ngan, Hextan Yuen Sheung; Small, William; Thomas, Gillian; Berek, Jonathan S.

2016-01-01

Purpose To provide evidence-based, resource-stratified global recommendations to clinicians and policymakers on the management and palliative care of women diagnosed with invasive cervical cancer. Methods ASCO convened a multidisciplinary, multinational panel of cancer control, medical and radiation oncology, health economic, obstetric and gynecologic, and palliative care experts to produce recommendations reflecting resource-tiered settings. A systematic review of literature from 1966 to 2015 failed to yield sufficiently strong quality evidence to support basic- and limited-resource setting recommendations; a formal consensus-based process was used to develop recommendations. A modified ADAPTE process was also used to adapt recommendations from existing guidelines. Results Five existing sets of guidelines were identified and reviewed, and adapted recommendations form the evidence base. Eight systematic reviews, along with cost-effectiveness analyses, provided indirect evidence to inform the consensus process, which resulted in agreement of 75% or greater. Recommendations Clinicians and planners should strive to provide access to the most effective evidence-based antitumor and palliative care interventions. If a woman cannot access these within her own or neighboring country or region, she may need to be treated with lower-tier modalities, depending on capacity and resources for surgery, chemotherapy, radiation therapy, and supportive and palliative care. For women with early-stage cervical cancer in basic settings, cone biopsy or extrafascial hysterectomy may be performed. Fertility-sparing procedures or modified radical or radical hysterectomy may be additional options in nonbasic settings. Combinations of surgery, chemotherapy, and radiation therapy (including brachytherapy) should be used for women with stage IB to IVA disease, depending on available resources. Pain control is a vital component of palliative care. Additional information is available at www.asco.org/rs-cervical-cancer-treatment-guideline and www.asco.org/guidelineswiki. It is the view of ASCO that health care providers and health care system decision makers should be guided by the recommendations for the highest stratum of resources available. The guideline is intended to complement but not replace local guidelines. PMID:28717717

Ethics in oncology: consulting for the investment industry.

PubMed

Berlin, Jordan; Bruinooge, Suanna S; Tannock, Ian F

2007-02-01

As Ethics Committee Chair, I am pleased to introduce the first in an ongoing series of ethics vignettes. These columns, which are based on true-to-life situations that arise in oncology research and practice, are intended to identify and explore important ethical issues and provide commentary that is specific to oncology. Please look for them periodically in both the Journal of Clinical Oncology and the Journal of Oncology Practice. The idea for publishing vignettes evolved through the joint efforts of the Ethics Committee and the Board of Directors. Rather than adopt a single set of ethical principles that applies vaguely to any situation and well to none, the Committee and the Board preferred to tackle ethical dilemmas individually, specifically, and directly. Because the Ethics Committee thought the ethical and legal implications of physician interactions with the investment industry were so important and timely, it chose to address this topic in both a position article, which was previously published in the January 20, 2007, issue of the Journal of Clinical Oncology (J Clin Oncol 25:338-340, 2007) and in its first vignette column. The Ethics Committee hopes this column will be the first of several that ASCO members will find helpful as they grapple with the many ethical issues that arise in daily practice in the field of oncology. Because these columns are intended to address the concerns of ASCO members, the Committee welcomes suggestions for future topics at vignettes@asco.org. Martin D. Abeloff, MD, Chair, Ethics Committee.

Integrated Information Systems for Electronic Chemotherapy Medication Administration

PubMed Central

Levy, Mia A.; Giuse, Dario A.; Eck, Carol; Holder, Gwen; Lippard, Giles; Cartwright, Julia; Rudge, Nancy K.

2011-01-01

Introduction: Chemotherapy administration is a highly complex and distributed task in both the inpatient and outpatient infusion center settings. The American Society of Clinical Oncology and the Oncology Nursing Society (ASCO/ONS) have developed standards that specify procedures and documentation requirements for safe chemotherapy administration. Yet paper-based approaches to medication administration have several disadvantages and do not provide any decision support for patient safety checks. Electronic medication administration that includes bar coding technology may provide additional safety checks, enable consistent documentation structure, and have additional downstream benefits. Methods: We describe the specialized configuration of clinical informatics systems for electronic chemotherapy medication administration. The system integrates the patient registration system, the inpatient order entry system, the pharmacy information system, the nursing documentation system, and the electronic health record. Results: We describe the process of deploying this infrastructure in the adult and pediatric inpatient oncology, hematology, and bone marrow transplant wards at Vanderbilt University Medical Center. We have successfully adapted the system for the oncology-specific documentation requirements detailed in the ASCO/ONS guidelines for chemotherapy administration. However, several limitations remain with regard to recording the day of treatment and dose number. Conclusion: Overall, the configured systems facilitate compliance with the ASCO/ONS guidelines and improve the consistency of documentation and multidisciplinary team communication. Our success has prompted us to deploy this infrastructure in our outpatient chemotherapy infusion centers, a process that is currently underway and that will require a few unique considerations. PMID:22043185

Chemo Before Surgery May Help Stomach Cancer

Cancer.gov

Chemotherapy given before surgery for cancer of the lower esophagus and stomach increased the number of patients surviving for five years compared to surgery alone, according to findings presented at the 2007 ASCO meeting in Chicago.

Epoetin and Darbepoetin Treatment for Adults with Cancer

MedlinePlus

... best possible care, the American Society of Clinical Oncology (ASCO) and the American Society of Hematology (ASH) ... to the rapid flow of scientific information in oncology, new evidence may have emerged since the time ...

77 FR 64755 - Medicare and Medicaid Programs; Electronic Health Record Incentive Program-Stage 2; Corrections

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-23

... EHR PQRS, ACO, Group Clinical Process/ Blood Pressure. Contact Information: Reporting PQRS, UDS... of hypertension and whose blood pressure was adequately controlled ( www.asco.org ;. cancer who are...

New Therapies Offer Valuable Options for Patients with Melanoma

Cancer.gov

Two phase III clinical trials of new therapies for patients with metastatic melanoma presented in June at the 2011 ASCO conference confirmed that vemurafenib and ipilimumab (Yervoy™) offer valuable new options for the disease.

One Decade Later: Trends and Disparities in the Application of Post-Mastectomy Radiotherapy Since the Release of the American Society of Clinical Oncology Clinical Practice Guidelines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dragun, Anthony E., E-mail: aedrag01@louisville.edu; Huang, Bin; Divison of Cancer Biostatistics, College of Public Health, University of Kentucky, Lexington, KY

2012-08-01

Purpose: In 2001 ASCO published practice guidelines for post mastectomy radiotherapy (PMRT). We analyzed factors that influence the receipt of radiotherapy therapy and trends over time. Methods and Materials: We analyzed 8889 women who underwent mastectomy as primary surgical treatment for stage II or III breast cancer between 1995 and 2008 using data from the Kentucky Cancer Registry. We categorized patients according to ASCO group: group 1, PMRT not routinely recommended (T2, N0); group 2, PMRT controversial/evidence insufficient (T1-2, N1); group 3, PMRT recommended or suggested (T3-4 or N2-3). Probability of receiving PMRT was assessed using logistic regression. Results: Overall,more » 24.0% of women received PMRT over the study period. The rates of PMRT for group 1, 2, and 3 were 7.5%, 19.5%, and 47.3%, respectively. Since 2001, there was an increase in the use of PMRT (from 21.1%-26.5%, P<.0001), which occurred mainly among group 3 members (from 40.8%-51.2%, P<.0001). The average rate remained constant in group 1 (from 7.1%-7.4%, P=.266) and decreased in group 2 (from 20.0%-18.1%, P<.0001). On multivariate analysis, the rate of PMRT was significantly lower for women aged >70 years (vs. younger), rural Appalachia (vs. non-Appalachia) populations, and Medicaid (vs. privately insured) patients. Conclusions: ASCO guidelines have influenced practice in an underserved state; however PMRT remains underused, even for highest-risk patients. Barriers exist for elderly, rural and poor patients, which independently predict for lack of adequate care. Updated guidelines are needed to clarify the use of PMRT for patients with T1-2, N1 disease.« less

Breast and gastrointestinal cancer updates from ASCO 2015.

PubMed

Dawood, Shaheenah

2015-01-01

This review focuses on the updates presented at the ASCO 2015 symposium in breast and gastrointestinal malignancies. Some were practice changing while others gave us an exciting glimpse into what's to come in the very near future. Immunotherapy was the buzz word this year with data presented on every tumor site. Data on the efficacy of anti PD-1 agents in colorectal, hepatocellular and gastric cancer were presented. In breast cancer we saw data on a new and exciting therapeutic target in the form of androgen receptor among triple receptor negative breast tumors presented. Positive results of the PALOMA 3 trial were presented that has given women with hormone receptor positive metastatic breast cancer another therapeutic option. Furthermore data on strategies to further improve anti her2 therapy, optimizing of chemotherapy in the early and advanced stage and various strategies to improve endocrine therapy among patients with breast cancer were presented.

[Using Twitter in oncology. Research, continuing education, and advocacy].

PubMed

De Fiore, Luciano; Ascierto, Paolo

2015-01-01

Traditional mass media coverage has been enhanced by Twitter, an interactive, real-time media, useful in health care, and particularly in oncology. Social media such as Twitter are gaining increasing acceptance as tools for instantaneous scientific dialogue. Professional medical societies such as ASCO and ESMO are using microblogging to expand the reach of scientific communications at and around their scientific meetings. To widen the message and maximize the potential for word-of-mouth marketing using Twitter, organizations (such as AIOM, ASCO or ESMO) and industries need a strategic communications plan to ensure on-going social media conversations. Twitter is a very powerful tool indeed that amplifies the results of scientific meetings, and conference organisers should put in place strategies to capitalise on this. This review demonstrates that cancer patients also share information more and more via Twitter about their disease, including diagnosis, symptoms, and treatments. This information could prove useful to health care providers.

Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline Focused Update

PubMed Central

Krop, Ian; Ismaila, Nofisat; Andre, Fabrice; Bast, Robert C.; Barlow, William; Collyar, Deborah E.; Hammond, M. Elizabeth; Kuderer, Nicole M.; Liu, Minetta C.; Mennel, Robert G.; Van Poznak, Catherine; Wolff, Antonio C.; Stearns, Vered

2018-01-01

Purpose This focused update addresses the use of MammaPrint (Agendia, Irvine, CA) to guide decisions on the use of adjuvant systemic therapy. Methods ASCO uses a signals approach to facilitate guideline updates. For this focused update, the publication of the phase III randomized MINDACT (Microarray in Node-Negative and 1 to 3 Positive Lymph Node Disease May Avoid Chemotherapy) study to evaluate the MammaPrint assay in 6,693 women with early-stage breast cancer provided a signal. An expert panel reviewed the results of the MINDACT study along with other published literature on the MammaPrint assay to assess for evidence of clinical utility. Recommendations If a patient has hormone receptor–positive, human epidermal growth factor receptor 2 (HER2)–negative, node-negative breast cancer, the MammaPrint assay may be used in those with high clinical risk to inform decisions on withholding adjuvant systemic chemotherapy due to its ability to identify a good-prognosis population with potentially limited chemotherapy benefit. Women in the low clinical risk category did not benefit from chemotherapy regardless of genomic MammaPrint risk group. Therefore, the MammaPrint assay does not have clinical utility in such patients. If a patient has hormone receptor–positive, HER2-negative, node-positive breast cancer, the MammaPrint assay may be used in patients with one to three positive nodes and a high clinical risk to inform decisions on withholding adjuvant systemic chemotherapy. However, such patients should be informed that a benefit from chemotherapy cannot be excluded, particularly in patients with greater than one involved lymph node. The clinician should not use the MammaPrint assay to guide decisions on adjuvant systemic therapy in patients with hormone receptor–positive, HER2-negative, node-positive breast cancer at low clinical risk, nor any patient with HER2-positive or triple-negative breast cancer, because of the lack of definitive data in these populations. Additional information can be found at www.asco.org/breast-cancer-guidelines and www.asco.org/guidelineswiki. PMID:28692382

Selection of Optimal Adjuvant Chemotherapy and Targeted Therapy for Early Breast Cancer: ASCO Clinical Practice Guideline Focused Update.

PubMed

Denduluri, Neelima; Chavez-MacGregor, Mariana; Telli, Melinda L; Eisen, Andrea; Graff, Stephanie L; Hassett, Michael J; Holloway, Jamie N; Hurria, Arti; King, Tari A; Lyman, Gary H; Partridge, Ann H; Somerfield, Mark R; Trudeau, Maureen E; Wolff, Antonio C; Giordano, Sharon H

2018-05-22

Purpose To update key recommendations of the ASCO guideline adaptation of the Cancer Care Ontario guideline on the selection of optimal adjuvant chemotherapy regimens for early breast cancer and adjuvant targeted therapy for breast cancer. Methods An Expert Panel conducted targeted systematic literature reviews guided by a signals approach to identify new, potentially practice-changing data that might translate to revised practice recommendations. Results The Expert Panel reviewed phase III trials that evaluated adjuvant capecitabine after completion of standard preoperative anthracycline- and taxane-based combination chemotherapy by patients with early-stage breast cancer HER2-negative breast cancer with residual invasive disease at surgery; the addition of 1 year of adjuvant pertuzumab to combination chemotherapy and trastuzumab for patients with early-stage, HER2-positive breast cancer; and the use of neratinib as extended adjuvant therapy for patients after combination chemotherapy and trastuzumab-based adjuvant therapy with early-stage, HER2-positive breast cancer. Recommendations Patients with early-stage HER2-negative breast cancer with pathologic, invasive residual disease at surgery following standard anthracycline- and taxane-based preoperative therapy may be offered up to six to eight cycles of adjuvant capecitabine. Clinicians may add 1 year of adjuvant pertuzumab to trastuzumab-based combination chemotherapy in patients with high-risk, early-stage, HER2-positive breast cancer. Clinicians may use extended adjuvant therapy with neratinib to follow trastuzumab in patients with early-stage, HER2-positive breast cancer. Neratinib causes substantial diarrhea, and diarrhea prophylaxis must be used. Additional information can be found at www.asco.org/breast-cancer-guidelines .

Enhancing the American Society of Clinical Oncology workforce information system with geographic distribution of oncologists and comparison of data sources for the number of practicing oncologists.

PubMed

Kirkwood, M Kelsey; Bruinooge, Suanna S; Goldstein, Michael A; Bajorin, Dean F; Kosty, Michael P

2014-01-01

The American Society of Clinical Oncology (ASCO) 2007 workforce report projected US oncologist shortages by 2020. Intervening years have witnessed shifting trends in both supply and demand, demonstrating the need to capture data in a dynamic manner. The ASCO Workforce Information System (WIS) provides an infrastructure to update annually emerging characteristics of US oncologists (medical oncologists, hematologist/oncologists, and hematologists). Several possible data sources exist to capture the number of oncologists in the United States. The WIS primarily uses the American Medical Association Physician Masterfile database because it provides detailed demographics. This analysis also compares total counts of oncologists from American Board of Internal Medicine (ABIM) certification reports, the National Provider Identifier (NPI) database, and Medicare Physician Compare data. The analysis also examines geographic distribution of oncologists by age and US population data. For each of the data sources, we pulled 2013 data. The Masterfile identified 13,409 oncologists. ABIM reported 13,757 oncologists. NPI listed 11,664 oncologists. Physician Compare identified 11,343 oncologists. Mapping of these data identifies distinct areas (primarily in central United States, Alaska, and Hawaii) that seem to lack ready access to oncologists. Efforts to survey oncologists about practice patterns will help determine if productivity and service delivery will change significantly. ASCO is committed to tracking oncologist supply and demand, as well as to providing timely analysis of strategies that will help address any shortages that may occur in specific regions or practice settings.

Exemestane Reduces Breast Cancer Risk in High-Risk Postmenopausal Women

Cancer.gov

Clinical trial results presented at the 2011 ASCO annual meeting showed that the aromatase inhibitor exemestane—used to treat early and advanced breast cancer—substantially reduced the risk of invasive breast cancer in high-risk postmenopausal women.

Leukemia - B-Cell Prolymphocytic Leukemia and Hairy Cell Leukemia

MedlinePlus

... a 1-page fact sheet that offers an introduction to CLL. This fact sheet is available as a PDF, so it is easy to print out. Cancer.Net Patient Education Video: View a short video led by an ASCO expert in leukemia ...

TAILORx finds no chemotherapy benefit for most early breast cancers

Cancer.gov

Findings from the TAILORx clinical trial show chemotherapy does not benefit most women with early breast cancer. The new data, released at the 2018 ASCO annual meeting, will help inform treatment decisions for many women with early-stage breast cancer.

Follow-up care, surveillance protocol, and secondary prevention measures for survivors of colorectal cancer: American Society of Clinical Oncology clinical practice guideline endorsement.

PubMed

Meyerhardt, Jeffrey A; Mangu, Pamela B; Flynn, Patrick J; Korde, Larissa; Loprinzi, Charles L; Minsky, Bruce D; Petrelli, Nicholas J; Ryan, Kim; Schrag, Deborah H; Wong, Sandra L; Benson, Al B

2013-12-10

The American Society of Clinical Oncology (ASCO) has a policy and set of procedures for endorsing recent clinical practice guidelines that have been developed by other professional organizations. The Cancer Care Ontario (CCO) Guideline on Follow-up Care, Surveillance Protocol, and Secondary Prevention Measures for Survivors of Colorectal Cancer was reviewed by ASCO for methodologic rigor and considered for endorsement. The ASCO Panel concurred with the CCO recommendations and recommended endorsement, with the addition of several qualifying statements. Surveillance should be guided by presumed risk of recurrence and functional status of the patient (important within the first 2 to 4 years). Medical history, physical examination, and carcinoembryonic antigen testing should be performed every 3 to 6 months for 5 years. Patients at higher risk of recurrence should be considered for testing in the more frequent end of the range. A computed tomography scan (abdominal and chest) is recommended annually for 3 years, in most cases. Positron emission tomography scans should not be used for surveillance outside of a clinical trial. A surveillance colonoscopy should be performed 1 year after the initial surgery and then every 5 years, dictated by the findings of the previous one. If a colonoscopy was not preformed before diagnosis, it should be done after completion of adjuvant therapy (before 1 year). Secondary prevention (maintaining a healthy body weight and active lifestyle) is recommended. If a patient is not a candidate for surgery or systemic therapy because of severe comorbid conditions, surveillance tests should not be performed. A treatment plan from the specialist should have clear directions on appropriate follow-up by a nonspecialist.

Screening, Assessment, and Care of Anxiety and Depressive Symptoms in Adults With Cancer: An American Society of Clinical Oncology Guideline Adaptation

PubMed Central

Andersen, Barbara L.; DeRubeis, Robert J.; Berman, Barry S.; Gruman, Jessie; Champion, Victoria L.; Massie, Mary Jane; Holland, Jimmie C.; Partridge, Ann H.; Bak, Kate; Somerfield, Mark R.; Rowland, Julia H.

2014-01-01

Purpose A Pan-Canadian Practice Guideline on Screening, Assessment, and Care of Psychosocial Distress (Depression, Anxiety) in Adults With Cancer was identified for adaptation. Methods American Society of Clinical Oncology (ASCO) has a policy and set of procedures for adapting clinical practice guidelines developed by other organizations. The guideline was reviewed for developmental rigor and content applicability. Results On the basis of content review of the pan-Canadian guideline, the ASCO panel agreed that, in general, the recommendations were clear, thorough, based on the most relevant scientific evidence, and presented options that will be acceptable to patients. However, for some topics addressed in the pan-Canadian guideline, the ASCO panel formulated a set of adapted recommendations based on local context and practice beliefs of the ad hoc panel members. It is recommended that all patients with cancer be evaluated for symptoms of depression and anxiety at periodic times across the trajectory of care. Assessment should be performed using validated, published measures and procedures. Depending on levels of symptoms and supplementary information, differing treatment pathways are recommended. Failure to identify and treat anxiety and depression increases the risk for poor quality of life and potential disease-related morbidity and mortality. This guideline adaptation is part of a larger survivorship guideline series. Conclusion Although clinicians may not be able to prevent some of the chronic or late medical effects of cancer, they have a vital role in mitigating the negative emotional and behavioral sequelae. Recognizing and treating effectively those who manifest symptoms of anxiety or depression will reduce the human cost of cancer. PMID:24733793

Identifying Health Information Technology Needs of Oncologists to Facilitate the Adoption of Genomic Medicine: Recommendations From the 2016 American Society of Clinical Oncology Omics and Precision Oncology Workshop.

PubMed

Hughes, Kevin S; Ambinder, Edward P; Hess, Gregory P; Yu, Peter Paul; Bernstam, Elmer V; Routbort, Mark J; Clemenceau, Jean Rene; Hamm, John T; Febbo, Phillip G; Domchek, Susan M; Chen, James L; Warner, Jeremy L

2017-09-20

At the ASCO Data Standards and Interoperability Summit held in May 2016, it was unanimously decided that four areas of current oncology clinical practice have serious, unmet health information technology needs. The following areas of need were identified: 1) omics and precision oncology, 2) advancing interoperability, 3) patient engagement, and 4) value-based oncology. To begin to address these issues, ASCO convened two complementary workshops: the Omics and Precision Oncology Workshop in October 2016 and the Advancing Interoperability Workshop in December 2016. A common goal was to address the complexity, enormity, and rapidly changing nature of genomic information, which existing electronic health records are ill equipped to manage. The subject matter experts invited to the Omics and Precision Oncology Workgroup were tasked with the responsibility of determining a specific, limited need that could be addressed by a software application (app) in the short-term future, using currently available genomic knowledge bases. Hence, the scope of this workshop was to determine the basic functionality of one app that could serve as a test case for app development. The goal of the second workshop, described separately, was to identify the specifications for such an app. This approach was chosen both to facilitate the development of a useful app and to help ASCO and oncologists better understand the mechanics, difficulties, and gaps in genomic clinical decision support tool development. In this article, we discuss the key challenges and recommendations identified by the workshop participants. Our hope is to narrow the gap between the practicing oncologist and ongoing national efforts to provide precision oncology and value-based care to cancer patients.

WITHDRAWN: Molecular classification of colorectal cancer: Current perspectives and controversies.

PubMed

Mohammed, Amrallah A; El-Tanni, Hani; El-Khatib, Hani M; Mirza, Ahmad A; El-Kashif, Amr T

2016-01-02

This article has been withdrawn at the request of the editor. The authors have plagiarized part of a paper that had already appeared in ASCO EDUCATIONAL BOOK (2014), 91-99 (http://meetinglibrary.asco.org/content/114000091-144). One of the conditions of submission of a paper for publication is that authors declare explicitly that their work is original and has not appeared in a publication elsewhere. Re-use of any data should be appropriately cited. As such this article represents an abuse of the scientific publishing system. The scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). Copyright © 2015 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

[Immune checkpoints inhibitors: Recent data from ASCO's meeting 2017 and perspectives].

PubMed

Kfoury, Maria; Disdero, Valentine; Vicier, Cécilé; Le Saux, Olivia; Gougis, Paul; Sajous, Christophe; Vignot, Stéphane

2018-06-19

Immune checkpoint inhibitors anti-PD-1, anti-PD-L1 and anti-CTLA-4 have been in development in several indications and have changed the face of cancer patients' management. Cancer immunotherapy was central in ASCO's meeting 2017. The identification of patients who could benefit most from immune checkpoint inhibitors is essential. The predictive value of PD-L1 status remains insufficient to select patients who could respond to immunotherapy. An extended search for new biomarkers predictive of response (INF-γ, mutational load) is ongoing, in order to better select responders. Immune checkpoint inhibitors have mainly been developed as monotherapy. However, the low response rate, between 10 and 30%, and the occurrence of resistance, contributes to the increment of new therapeutic strategies. This review summarizes the results of combination trials of two immune checkpoint inhibitors, combination of immunotherapy with conventional chemotherapy, radiotherapy or targeted therapies active on the oncogenic addiction pathway. Copyright © 2018 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

ASCO 2016: highlights in breast cancer.

PubMed

Bartsch, Rupert; Bergen, Elisabeth

2016-01-01

At the 2016 ASCO Annual Meeting, several pertinent studies in the field of breast cancer were presented. MA17.R was the first randomized phase III trial to evaluate the prolongation of adjuvant aromatase-inhibitor (AI) therapy from 5 to 10 years; while a significant reduction of disease-free survival events was observed in the extended treatment group, the absolute difference was relatively small and longer endocrine therapy resulted in a higher fracture rate. A combined analysis of three North American trials emphasized the superiority of anthracycline containing adjuvant chemotherapy regimens compared with docetaxel/cyclophosphamide (TC), while the PANTHER trial investigated dose-dense tailored adjuvant treatment. In metastatic breast cancer, the main interest was on cyclin-dependent kinase (CDK) 4/6 inhibitors. In PALOMA-2, the addition of palbociclib to letrozole prolonged progression-free survival (PFS) from 14.5 to 24.8 months resulting in the longest PFS data ever reported in the first-line setting. A subgroup analysis of premenopausal patients accrued to PALOMA-3 indicated that in this patient subset, ovarian function suppression plus fulvestrant and palbociclib yielded results comparable to the postmenopausal population. ESR1 mutations were another focus of interest as these activating mutations in the gene coding for the estrogen receptor alpha apparently evolve under the selection pressure of AI therapy.

Clinical cancer advances 2006: major research advances in cancer treatment, prevention, and screening--a report from the American Society of Clinical Oncology.

PubMed

Ozols, Robert F; Herbst, Roy S; Colson, Yolonda L; Gralow, Julie; Bonner, James; Curran, Walter J; Eisenberg, Burton L; Ganz, Patricia A; Kramer, Barnett S; Kris, Mark G; Markman, Maurie; Mayer, Robert J; Raghavan, Derek; Reaman, Gregory H; Sawaya, Raymond; Schilsky, Richard L; Schuchter, Lynn M; Sweetenham, John W; Vahdat, Linda T; Winn, Rodger J

2007-01-01

A MESSAGE FROM ASCO's PRESIDENT For the second consecutive year, the American Society of Clinical Oncology (ASCO) is publishing Clinical Cancer Advances: Major Research Advances in Cancer Treatment, Prevention, and Screening, an annual review of the most significant cancer research presented or published over the past year. ASCO developed this report to demonstrate the enormous progress being made on the front lines of cancer research today. The report is intended to give all those with an interest in cancer care-the general public, cancer patients and physicians, policymakers, oncologists, and other medical professionals-an accessible summary of the year's most important cancer research advances. These pages report on new targeted therapies that are improving survival and response rates in hard-to-treat cancers such as kidney cancer, HER-2-positive breast cancer, head and neck cancer, and chronic myelogenous leukemia; the FDA's approval of the world's first preventive vaccine for human papillomavirus (HPV), which has the potential to dramatically reduce the global burden of cervical cancer; and advances in the fast-growing field of personalized medicine, including a new lung cancer test that could help physicians better target treatments and predict prognosis. These advances are only part of the landscape. Survival rates are on the rise, the number of cancer deaths in the United States began declining for the first time since 1930, and new research is showing that the rates of certain common cancers, such as those of the breast and colon, have stabilized, and may have even begun to decline. However, cancer research still faces a number of major obstacles. At a time of extraordinary scientific potential, declining federal funding of cancer research threatens to stall or even reverse recent progress. Such funding cuts have already led to fewer clinical trials, fewer talented young physicians entering the field, and a growing bottleneck of basic science discoveries waiting to be "translated" into useful therapies and diagnostics. In addition to highlighting the major research advances over the past year, this report also identifies key barriers to accelerating the pace of cancer research and outlines ASCO's recommendations for overcoming them. Despite these and other challenges, there is much good news on the front lines of cancer research. This report demonstrates the essential role of clinical cancer research in finding new and better ways to treat, diagnose, and prevent a group of diseases that strike half of men and one-third of women in the United States.

[Pembrolizumab for the treatment of melanoma: updates and perspectives.

PubMed

Chiarion Sileni, Vanna; Mandalà, Mario; Queirolo, Paola

2017-12-01

Checkpoint inhibitors immunotherapy was a breakthrough in anti-tumor treatments. Anti-PD-1 monoclonal antibodies are now a standard of treatment for advanced melanoma patients, with a 3-year overall survival of over 50% and a low rate (<20%) of severe toxicities in the phase 3 studies. The aim of this review was to report the most important updates on anti-PD-1 drug pembrolizumab from ASCO (American Society of Clinical Oncology) and ESMO (European Society for Medical Oncology) 2017 Annual Meetings.

Oncologist Support for Consolidated Payments for Cancer Care Management in the United States.

PubMed

Narayanan, Siva; Hautamaki, Emily

2016-07-01

The cost of cancer care in the United States continues to rise, with pressure on oncologists to provide high-quality, cost-effective care while maintaining the financial stability of their practice. Existing payment models do not typically reward care coordination or quality of care. In May 2014, the American Society of Clinical Oncology (ASCO) released a payment reform proposal (revised in May 2015) that includes a new payment structure for quality-of-care performance metrics. To assess US oncologists' perspectives on and support for ASCO's payment reform proposal, and to determine use of quality-of-care metrics, factors influencing their perception of value of new cancer drugs, the influence of cost on treatment decisions, and the perceptions of the reimbursement climate in the country. Physicians and medical directors specializing in oncology in the United States practicing for at least 2 years and managing at least 20 patients with cancer were randomly invited, from an online physician panel, to participate in an anonymous, cross-sectional, 15-minute online survey conducted between July and November 2014. The survey assessed physicians' level of support for the payment reform, use of quality-of-care metrics, factors influencing their perception of the value of a new cancer drug, the impact of cost on treatment decision-making, and their perceptions of the overall reimbursement climate. Descriptive statistics (chi-square tests and t-tests for discrete and continuous variables, respectively) were used to analyze the data. Logistic regression models were constructed to evaluate the main payment models described in the payment reform proposal. Of the 231 physicians and medical directors who participated in this study, approximately 50% strongly or somewhat supported the proposed payment reform. Stronger support was seen among survey respondents who were male, who rated the overall reimbursement climate as excellent/good, who have a contract with a commercial payer that reimburses for dispensed oral cancer drugs, or who practice in a hospital setting. The use of at least 1 quality-of-care metric was more common among respondents participating in an accountable care organization (ACO) than among those not participating in an ACO (92.6% vs 83.2%, respectively; P = .0380). The most common metric used by the physicians in their practice setting was patient satisfaction scores (60.1%). Accountability for delivering high-quality care was supported by 74.9% of respondents; those who practice in a hospital setting were twice as likely as those in private practice to support accountability for quality of care (81.3% vs 67.6%; odds ratio, 2.1; P = .0176). Support for ASCO's payment reform proposal is mixed among oncology physicians and medical directors, underscoring the importance of continuous and broader engagement of practicing physicians around the country via outreach and dialogue on topics that impact their clinical practices, as well as providing education or awareness activities by ASCO to its membership.

Cloud and boundary layer interactions over the Arctic sea-ice in late summer

NASA Astrophysics Data System (ADS)

Shupe, M. D.; Persson, P. O. G.; Brooks, I. M.; Tjernström, M.; Sedlar, J.; Mauritsen, T.; Sjogren, S.; Leck, C.

2013-05-01

Observations from the Arctic Summer Cloud Ocean Study (ASCOS), in the central Arctic sea-ice pack in late summer 2008, provide a detailed view of cloud-atmosphere-surface interactions and vertical mixing processes over the sea-ice environment. Measurements from a suite of ground-based remote sensors, near surface meteorological and aerosol instruments, and profiles from radiosondes and a helicopter are combined to characterize a week-long period dominated by low-level, mixed-phase, stratocumulus clouds. Detailed case studies and statistical analyses are used to develop a conceptual model for the cloud and atmosphere structure and their interactions in this environment. Clouds were persistent during the period of study, having qualities that suggest they were sustained through a combination of advective influences and in-cloud processes, with little contribution from the surface. Radiative cooling near cloud top produced buoyancy-driven, turbulent eddies that contributed to cloud formation and created a cloud-driven mixed layer. The depth of this mixed layer was related to the amount of turbulence and condensed cloud water. Coupling of this cloud-driven mixed layer to the surface boundary layer was primarily determined by proximity. For 75% of the period of study, the primary stratocumulus cloud-driven mixed layer was decoupled from the surface and typically at a warmer potential temperature. Since the near-surface temperature was constrained by the ocean-ice mixture, warm temperatures aloft suggest that these air masses had not significantly interacted with the sea-ice surface. Instead, back trajectory analyses suggest that these warm airmasses advected into the central Arctic Basin from lower latitudes. Moisture and aerosol particles likely accompanied these airmasses, providing necessary support for cloud formation. On the occasions when cloud-surface coupling did occur, back trajectories indicated that these air masses advected at low levels, while mixing processes kept the mixed layer in equilibrium with the near-surface environment. Rather than contributing buoyancy forcing for the mixed-layer dynamics, the surface instead simply appeared to respond to the mixed-layer processes aloft. Clouds in these cases often contained slightly higher condensed water amounts, potentially due to additional moisture sources from below.

Cloud and boundary layer interactions over the Arctic sea ice in late summer

NASA Astrophysics Data System (ADS)

Shupe, M. D.; Persson, P. O. G.; Brooks, I. M.; Tjernström, M.; Sedlar, J.; Mauritsen, T.; Sjogren, S.; Leck, C.

2013-09-01

Observations from the Arctic Summer Cloud Ocean Study (ASCOS), in the central Arctic sea-ice pack in late summer 2008, provide a detailed view of cloud-atmosphere-surface interactions and vertical mixing processes over the sea-ice environment. Measurements from a suite of ground-based remote sensors, near-surface meteorological and aerosol instruments, and profiles from radiosondes and a helicopter are combined to characterize a week-long period dominated by low-level, mixed-phase, stratocumulus clouds. Detailed case studies and statistical analyses are used to develop a conceptual model for the cloud and atmosphere structure and their interactions in this environment. Clouds were persistent during the period of study, having qualities that suggest they were sustained through a combination of advective influences and in-cloud processes, with little contribution from the surface. Radiative cooling near cloud top produced buoyancy-driven, turbulent eddies that contributed to cloud formation and created a cloud-driven mixed layer. The depth of this mixed layer was related to the amount of turbulence and condensed cloud water. Coupling of this cloud-driven mixed layer to the surface boundary layer was primarily determined by proximity. For 75% of the period of study, the primary stratocumulus cloud-driven mixed layer was decoupled from the surface and typically at a warmer potential temperature. Since the near-surface temperature was constrained by the ocean-ice mixture, warm temperatures aloft suggest that these air masses had not significantly interacted with the sea-ice surface. Instead, back-trajectory analyses suggest that these warm air masses advected into the central Arctic Basin from lower latitudes. Moisture and aerosol particles likely accompanied these air masses, providing necessary support for cloud formation. On the occasions when cloud-surface coupling did occur, back trajectories indicated that these air masses advected at low levels, while mixing processes kept the mixed layer in equilibrium with the near-surface environment. Rather than contributing buoyancy forcing for the mixed-layer dynamics, the surface instead simply appeared to respond to the mixed-layer processes aloft. Clouds in these cases often contained slightly higher condensed water amounts, potentially due to additional moisture sources from below.

Treatment Extends Survival for Women with Cervical Cancer

Cancer.gov

Patients with locally advanced cervical cancer who received gemcitabine (Gemzar®) both as part of initial treatment and as part of therapy following primary treatment had improved survival compared with patients whose treatment did not include gemcitabine, according to findings presented at the 2009 ASCO meeting in Orlando.

Assessment of Erysiphe necator ascospore release models for use in the Mediterranean climate of western Oregon

USDA-ARS?s Scientific Manuscript database

Predictive models have been developed in several major grape growing regions to correlate environmental conditions to Erysiphe necator ascospore release; however, these models may not accurately predict ascospore release in other viticulture regions with differing climatic conditions. To assess asco...

The birth of the subspecialty of medical oncology and examples of its early scientific foundations.

PubMed

Band, Pierre R

2010-08-01

"Passion is not accepting defeat."--Emil Frei III. In the early 1950s, an experimental and clinical program characterized by unique cross-fertilization was developed. The clinical importance of experimental animal models in drug screening and in establishing key chemotherapy concepts and the role of the pioneers of medical oncology in the design of the various phases of drug trials, using childhood acute leukemia and breast cancer as models, are discussed. Over a short time and with only a few drugs, principles of chemotherapy were laid out, which led to cures in such diseases as childhood acute leukemia and Hodgkin's disease and to improved disease-free survival in breast cancer. It is these and other achievements that paved the way to medical oncology. At the instigation of the American Society of Clinical Oncology (ASCO), the American Board of Internal Medicine made inquiries about a subspecialty in oncology. ASCO and B. J. Kennedy, MD, played key roles in the events leading to the official recognition of medical oncology as a new subspecialty of internal medicine in 1972.

Electronic health records (EHRs): supporting ASCO's vision of cancer care.

PubMed

Yu, Peter; Artz, David; Warner, Jeremy

2014-01-01

ASCO's vision for cancer care in 2030 is built on the expanding importance of panomics and big data, and envisions enabling better health for patients with cancer by the rapid transformation of systems biology knowledge into cancer care advances. This vision will be heavily dependent on the use of health information technology for computational biology and clinical decision support systems (CDSS). Computational biology will allow us to construct models of cancer biology that encompass the complexity of cancer panomics data and provide us with better understanding of the mechanisms governing cancer behavior. The Agency for Healthcare Research and Quality promotes CDSS based on clinical practice guidelines, which are knowledge bases that grow too slowly to match the rate of panomic-derived knowledge. CDSS that are based on systems biology models will be more easily adaptable to rapid advancements and translational medicine. We describe the characteristics of health data representation, a model for representing molecular data that supports data extraction and use for panomic-based clinical research, and argue for CDSS that are based on systems biology and are algorithm-based.

Assessing the New American Society of Clinical Oncology/College of American Pathologists Guidelines for HER2 Testing by Fluorescence In Situ Hybridization: Experience of an Academic Consultation Practice.

PubMed

Press, Michael F; Villalobos, Ivonne; Santiago, Angela; Guzman, Roberta; Cervantes, Monica; Gasparyan, Armen; Campeau, Anaamika; Ma, Yanling; Tsao-Wei, Denice D; Groshen, Susan

2016-04-15

Context .- Evaluation of HER2 gene amplification by fluorescence in situ hybridization (FISH) was changed by recent American Society of Clinical Oncology/College of American Pathologists (ASCO-CAP) guidelines. Objective . -To determine frequencies and assess patterns of HER2 protein expression for each ASCO-CAP guideline FISH category among 7526 breast cancers accrued to our consultation practice. Design .- We retrospectively reevaluated the HER2 FISH status of breast cancers in our consultation practice according to ASCO-CAP FISH guidelines, and documented HER2 protein levels in each category. Results . -According to new guidelines, 17.7% of our consultation breast cancers were "ISH-positive" with HER2:CEP17 FISH ratios ≥2.0 and average HER2 gene copies per cell ≥4.0 (group 1); 0.4% were "ISH-positive" with ratios ≥2.0 and average copies <4.0 (group 2); 0.6% were "ISH-positive" with ratios <2.0 and average copies ≥6.0 (group 3); 4.6% were "ISH-equivocal" with ratios <2.0 and average copies ≥4.0 and <6.0 (group 4); and 76.7% were "ISH-negative" with ratios <2.0 and average copies <4.0 (group 5). However, only groups 1 (HER2 amplified) and 5 (HER2 not amplified) agreed with our previously reported status, and only these groups demonstrated the expected immunohistochemistry status, overexpression and low expression, respectively. Groups 2 and 4 breast cancers lacked overexpression, whereas group 3 was not significantly associated with either increased or decreased HER2 expression. Conclusions .- Although the status of approximately 95% of our cases (groups 1 and 5) is not affected by the new guidelines, those of the other 5% (groups 2-4) conflict with previous HER2 gene amplification status and with HER2 status by immunohistochemistry.

Cloud condensation nuclei closure study on summer arctic aerosol

NASA Astrophysics Data System (ADS)

Martin, M.; Chang, R. Y.-W.; Sierau, B.; Sjogren, S.; Swietlicki, E.; Abbatt, J. P. D.; Leck, C.; Lohmann, U.

2011-03-01

We present an aerosol - cloud condensation nuclei CCN) closure study on summer high Arctic aerosol based on measurements that were carried out in summer 2008 during the Arctic Summer Cloud Ocean Study (ASCOS) on board the Swedish ice breaker Oden. The data presented here were collected during a three-week time period in the pack ice (>85° N) when the icebreaker Oden was moored to an ice floe and drifted passively during the most biological active period into autumn freeze up conditions. CCN number concentrations were obtained using two CCN counters measuring at different supersaturations. The directly measured CCN number concentration is then compared with a CCN number concentration calculated using both bulk aerosol mass composition data from an aerosol mass spectrometer and aerosol number size distributions obtained from a differential mobility particle sizer, assuming κ-Köhler theory and an internally mixed aerosol. For the two highest measured supersaturations, 0.73 and 0.41%, closure could not be achieved with the investigated settings concerning hygroscopicity and density. The calculated CCN number concentration was always higher than the measured one. One possible explanation is that the smaller particles that activate at these supersaturations have a relative larger insoluble organic mass fraction and thus are less good CCN than the larger particles. At 0.20, 0.15 and 0.10% supersaturation, the measured CCN number can be represented with different parameters for the hygroscopicity and density of the particles. For the best agreement of the calculated CCNnumber concentration with the measured one the organic fraction of the aerosol needs to be nearly insoluble (қorg=0.02). However, this is not unambigious and қorg=0.2 is found as an upper limit at 0.1% supersaturation.

Estrogen receptor and progesterone receptor status of breast cancer patients of eastern India: A multi-institutional study.

PubMed

Chatterjee, Koushik; Bhaumik, Gautam; Chattopadhyay, Bhargab

2018-01-01

There is a paucity of any significant data on the estrogen receptor (ER) and progesterone receptor (PR) status of breast cancer patients from the eastern part of India. This study aims to document the ER and PR status of breast cancer patients in the eastern Indian population, as catered by two premier tertiary care hospitals in Kolkata. All breast cancer patients registered between January 1, 2013 and December 31, 2015, in the Departments of Oncology, of IPGMER and SSKM Hospitals and R. G. Kar Medical College and Hospital, Kolkata, who had at least undergone a core biopsy or surgery, were analyzed retrospectively for documentation of their ER and PR status, using the 2010 American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) interpretation guidelines. Over a period of 3 years, a total of 927 patients were included for the study. A total of 825 (89%) patients had their ER and PR data available for evaluation. ER and PR positive was seen in 312 (37.82%) patients, ER and PR negative in 399 (48.36%) patients, ER positive and PR negative in 71 (8.6%) patients, and ER negative and PR positive results was found in 43 (5.21%) patients. This is the first multi-institutional documentation of ER and PR status from eastern India, having a modest number of patients and one of the earliest documentations using the latest ASCO/CAP interpretation guidelines. These findings resemble the data from the south and also reiterate the fact that majority of the Indian breast cancer patients are still ER and PR negative in spite of the changes in the interpretation guidelines.

Targeting the VEGF pathway: antiangiogenic strategies in the treatment of non-small cell lung cancer.

PubMed

Aita, Marianna; Fasola, Gianpiero; Defferrari, Carlotta; Brianti, Annalisa; Bello, Maria Giovanna Dal; Follador, Alessandro; Sinaccio, Graziella; Pronzato, Paolo; Grossi, Francesco

2008-12-01

The management of advanced non-small cell lung cancer (NSCLC) has evolved considerably in recent years, due to a progressive understanding of tumour biology and the identification of promising molecular targets. Several agents have been developed so far inhibiting vascular endothelial growth factor (VEGF) - a key protein in tumour neoangiogenesis, growth and dissemination - or its receptor signalling system. The finding in study E4599 of a survival benefit for carboplatin-paclitaxel plus bevacizumab - a humanised anti-VEGF monoclonal antibody - over chemotherapy (CT) alone led the U.S. Food and Drug Administration (FDA) to approve the novel combination for first-line treatment of patients with unresectable, locally advanced, recurrent or metastatic non-squamous NSCLC. In a randomised phase III trial presented at the American Society of Clinical Oncology (ASCO) 2007 Annual Meeting, patients receiving cisplatin-gemcitabine plus bevacizumab experienced a significantly longer progression-free survival (PFS) compared to the standard arm. Based on these data, the European Medicines Agency (EMEA) has granted marketing authorisation for bevacizumab in addition to any platinum-based CT for first-line treatment of advanced NSCLC other than predominantly squamous histology. Aim of this report is to provide an overview on bevacizumab in NSCLC, with special emphasis on clinical results presented at ASCO last meeting. Multitargeted tyrosine kinase inhibitors (TKIs), sharing a focus on both the angiogenesis process and additional cell-surface receptors, and VEGF Trap, a novel fusion protein with markedly higher affinity for VEGF than bevacizumab, will be briefly discussed as well.

Genetic heterogeneity in HER2 testing may influence therapy eligibility.

PubMed

Bernasconi, Barbara; Chiaravalli, Anna Maria; Finzi, Giovanna; Milani, Katia; Tibiletti, Maria Grazia

2012-05-01

Prospective studies have demonstrated that approximately 20% of HER2 testing may be inaccurate. When carefully validated testing is conducted, available data do not clearly demonstrate the superiority of either IHC or fluorescence in situ hybridization (FISH) as a predictor of benefit from anti-HER2 therapy. In addition, the interpretation of the findings of HER2 tests according to international guidelines is not uniform. The American Society of Clinical Oncology (ASCO) and the College of American Pathologists (CAP) recently published practice guidelines for a definition of HER2 amplification heterogeneity that can give rise to discrepant results between IHC and FISH assays for HER2. In this article, we compare the HER2 status of 291 non consecutive breast cancers. The status is determined by both IHC and FISH approaches, using a specific FISH strategy to investigate genetic heterogeneity. Our data demonstrate that HER2 amplified cells may be found as diffuse, clustered in a specific area or section, intermingled with non-amplified cells or confined to metastatic nodules. The correct evaluation of ratio value in the presence of genetic heterogeneity and of polysomy contributes to the accurate assessment of HER2 status and potentially affects the selection of appropriate anti-HER2 therapy. By taking into account the presence of different genetic cell populations, the immunotherapy eligibility criteria for HER2 FISH scoring proposed in the CAP (2009) and SIGU guidelines identify an additional subset of cases for trastuzumab or lapatinib therapy compared to the ASCO/CAP (2007) guidelines.

American Society of Clinical Oncology Summit on Addressing Obesity Through Multidisciplinary Provider Collaboration: Key Findings and Recommendations for Action.

PubMed

Ligibel, Jennifer A; Alfano, Catherine M; Hershman, Dawn L; Merrill, Janette K; Basen-Engquist, Karen; Bloomgarden, Zachary T; Demark-Wahnefried, Wendy; Dixon, Suzanne; Hassink, Sandra G; Jakicic, John M; Morton, John Magaña; Okwuosa, Tochi M; Powell-Wiley, Tiffany M; Rothberg, Amy E; Stephens, Mark; Streett, Sarah E; Wild, Robert A; Westman, Eric A; Williams, Ronald J; Wollins, Dana S; Hudis, Clifford A

2017-11-01

Given the increasing evidence that obesity increases the risk of developing and dying from malignancy, the American Society of Clinical Oncology (ASCO) launched an Obesity Initiative in 2013 that was designed to increase awareness among oncology providers and the general public of the relationship between obesity and cancer and to promote research in this area. Recognizing that the type of societal change required to impact the obesity epidemic will require a broad-based effort, ASCO hosted the "Summit on Addressing Obesity through Multidisciplinary Collaboration" in 2016. This meeting was held to review current challenges in addressing obesity within the respective health care provider communities and to identify priorities that would most benefit from a collective and cross-disciplinary approach. Efforts focused on four key areas: provider education and training; public education and activation; research; and policy and advocacy. Summit attendees discussed current challenges in addressing obesity within their provider communities and identified priorities that would most benefit from multidisciplinary collaboration. A synopsis of recommendations to facilitate future collaboration, as well as examples of ongoing cooperative efforts, provides a blueprint for multidisciplinary provider collaboration focused on obesity prevention and treatment. © 2017 The Obesity Society.

National survey of perspectives of palliative radiation therapy: role, barriers, and needs.

PubMed

McCloskey, Susan A; Tao, May Lin; Rose, Christopher M; Fink, Arlene; Amadeo, Alessandra M

2007-01-01

Despite growth of palliative care programs and evidence on the effectiveness of radiotherapy in palliating cancer symptoms, radiotherapy is probably underused in this setting. Radiation and medical oncologists and palliative medicine specialists were surveyed regarding the perceived role of palliative radiotherapy and barriers to its use. The survey was sent electronically to all physician members of the American Society for Therapeutic Radiology and Oncology (ASTRO) and the American Academy of Hospice and Palliative Medicine (AAHPM) and a random sample of American Society of Clinical Oncology (ASCO) members, with known e-mail addresses. Response rates were 27%, 14% and 26% for ASTRO, ASCO, and AAHPM respondents, respectively. Although most felt radiotherapy is an effective and important option for palliation of some common cancer symptoms, referrals for such therapy may be declining. Most agreed that radiation oncologists should be more involved in palliative care; however, multiple barriers were identified, such as poor reimbursement, emotional burden of care, insufficient training/knowledge, and the sense of unwillingness of others to share delivery of such services. Although multiple barriers limit optimal integration, most agree that there should be greater national and professional society efforts to promote the advancement of radiation oncology in the area of palliative care.

Genomics in personalized cancer medicine and its impact on early drug development in China: report from the 6th Annual Meeting of the US Chinese Anti-Cancer Association (USCACA) at the 50th ASCO Annual Meeting.

PubMed

Zhang, Wei; Cheng, Shi-Yuan; Hou, Li-Fang; Yan, Li; Tong, Yun-Guang

2014-08-01

The 6th Annual Meeting of the United States Chinese Anti-Cancer Association (USCACA) was held in conjunction with the 50th Annual Meeting of American Society of Clinical Oncology (ASCO) on May 30, 2014 in Chicago, Illinois, the United States of America. With a focus on personalized medicine, the conference featured novel approaches to investigate genomic aberrations in cancer cells and innovative clinical trial designs to expedite cancer drug development in biomarker-defined patient populations. A panel discussion further provided in-depth advice on advancing development of personalized cancer medicines in China. The conference also summarized USCACA key initiatives and accomplishments, including two awards designated to recognize young investigators from China for their achievements and to support their training in the United States. As an effort to promote international collaboration, USCACA will team up with Chinese Society of Clinical Oncology (CSCO) to host a joint session on "Breakthrough Cancer Medicines" at the upcoming CSCO Annual Meeting on September 20th, 2014 in Xiamen, China.

Clinical cancer advances 2007: major research advances in cancer treatment, prevention, and screening--a report from the American Society of Clinical Oncology.

PubMed

Gralow, Julie; Ozols, Robert F; Bajorin, Dean F; Cheson, Bruce D; Sandler, Howard M; Winer, Eric P; Bonner, James; Demetri, George D; Curran, Walter; Ganz, Patricia A; Kramer, Barnett S; Kris, Mark G; Markman, Maurie; Mayer, Robert J; Raghavan, Derek; Ramsey, Scott; Reaman, Gregory H; Sawaya, Raymond; Schuchter, Lynn M; Sweetenham, John W; Vahdat, Linda T; Davidson, Nancy E; Schilsky, Richard L; Lichter, Allen S

2008-01-10

A MESSAGE FROM ASCO'S PRESIDENT: For the third year, the American Society of Clinical Oncology (ASCO) is publishing Clinical Cancer Advances: Major Research Advances in Cancer Treatment, Prevention, and Screening, an annual review of the most significant cancer research presented or published over the past year. ASCO publishes this report to demonstrate the important progress being made on the front lines of clinical cancer research today. The report is intended to give all those with an interest in cancer care-the general public, cancer patients and organizations, policymakers, oncologists, and other medical professionals-an accessible summary of the year's most important cancer research advances. These pages report on the use of magnetic resonance imaging for breast cancer screening, the association between hormone replacement therapy and breast cancer incidence, the link between human papillomavirus and head and neck cancers, and the use of radiation therapy to prevent lung cancer from spreading. They also report on effective new targeted therapies for cancers that have been historically difficult to treat, such as liver cancer and kidney cancer, among many others. A total of 24 advances are featured in this year's report. These advances and many more over the past several years show that the nation's long-term investment in cancer research is paying off. But there are disturbing signs that progress could slow. We are now in the midst of the longest sustained period of flat government funding for cancer research in history. The budgets for the National Institutes of Health and the National Cancer Institute (NCI) have been unchanged for four years. When adjusted for inflation, cancer research funding has actually declined 12% since 2004. These budget constraints limit the NCI's ability to fund promising cancer research. In the past several years the number of grants that the NCI has been able to fund has significantly decreased; this year, in response to just the threat of a 10% budget cut, the nation's Clinical Trials Cooperative Groups reduced the number of patients participating in clinical trials by almost 2,000 and senior researchers report that many of the brightest young minds no longer see the promise of a career in science, choosing other careers instead. It's time to renew the nation's commitment to cancer research. Without additional support, the opportunity to build on the extraordinary progress to date will be lost or delayed. This report demonstrates the essential role that clinical cancer research plays in finding new and better ways to care for the more than 1.4 million people expected to be diagnosed with cancer this year. I want to thank the Editorial Board members, the Specialty Editors, and the ASCO Cancer Communications Committee for their dedicated work to develop this report. I hope you find it useful. Sincerely, Nancy E. Davidson, MD President American Society of Clinical Oncology.

Global Practice and Efficiency of Multidisciplinary Tumor Boards: Results of an American Society of Clinical Oncology International Survey

PubMed Central

Charara, Raghid N.; Kreidieh, Firas Y.; Eaton, Vanessa; Litvin, Kate; Farhat, Rania A.; Khoury, Katia E.; Breidy, Juliana; Tamim, Hani; Eid, Toufic A.

2015-01-01

Purpose Multidisciplinary tumor boards (MDTBs) are universally recommended, but recent literature has challenged their efficiency. Methods The American Society of Clinical Oncology (ASCO) conducted a survey of a randomly selected cohort of international ASCO members. The survey was built on SurveyMonkey and was sent via e-mail to a sample of 5,357 members. Results In all, 501 ASCO members practicing outside the United States responded, and 86% of them participated in MDTBs at their own institutions. Those who attended represented a variety of disciplines in 70% to 86% of all MDTBs. The majority of MDTBs held weekly specialty and/or general meetings. Eighty-nine percent of 409 respondents attended for advice on treatment decisions. Survey respondents reported changes of 1% to 25% in treatment plans for 44% to 49% of patients with breast cancer and in 47% to 50% of patients with colorectal cancer. They reported 25% to 50% changes in surgery type and/or treatment plans for 14% to 21% of patients with breast cancer and 12% to 18% of patients with colorectal cancer. Of the 430 respondents 96% said overall benefit to patients was worth the time and effort spent at MDTBs, and 96% said that MDTBs have teaching value. Mini tumor boards held with whatever types of specialists were available were considered valid. In all, 94.8% (425 of 448) said that MDTBs should be required in institutions in which patients with cancer are treated. Conclusion MDTBs are commonplace worldwide. A majority of respondents attend them to obtain recommendations, and they report changes in patient management. Change occurred more frequently with nonmedical oncologists and with physicians who had less than 15 years in practice. MDTBs helped practitioners make management decisions. Mini tumor boards may improve time efficiency and are favored when the full team is not available. Suggestions for improving MDTBs included making them more efficient, better selection and preparation of cases, choosing an effective team leader, and improving how time is used, but more research is needed on ways to improve the efficiency of MDTBs. PMID:28804774

Systemic Therapy for Stage IV Non-Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update.

PubMed

Hanna, Nasser; Johnson, David; Temin, Sarah; Baker, Sherman; Brahmer, Julie; Ellis, Peter M; Giaccone, Giuseppe; Hesketh, Paul J; Jaiyesimi, Ishmael; Leighl, Natasha B; Riely, Gregory J; Schiller, Joan H; Schneider, Bryan J; Smith, Thomas J; Tashbar, Joan; Biermann, William A; Masters, Gregory

2017-10-20

Purpose Provide evidence-based recommendations updating the 2015 ASCO guideline on systemic therapy for patients with stage IV non-small-cell lung cancer (NSCLC). Methods The ASCO NSCLC Expert Panel made recommendations based on a systematic review of randomized controlled trials from February 2014 to December 2016 plus the Cancer Care Ontario Program in Evidence-Based Care's update of a previous ASCO search. Results This guideline update reflects changes in evidence since the previous guideline update. Fourteen randomized controlled trials provide the evidence base; earlier phase trials also informed recommendation development. Recommendations New or revised recommendations include the following. Regarding first-line treatment for patients with non-squamous cell carcinoma or squamous cell carcinoma (without positive markers, eg, EGFR/ALK /ROS1), if the patient has high programmed death ligand 1 (PD-L1) expression, pembrolizumab should be used alone; if the patient has low PD-L1 expression, clinicians should offer standard chemotherapy. All other clinical scenarios follow 2015 recommendations. Regarding second-line treatment in patients who received first-line chemotherapy, without prior immune checkpoint therapy, if NSCLC tumor is positive for PD-L1 expression, clinicians should use single-agent nivolumab, pembrolizumab, or atezolizumab; if tumor has negative or unknown PD-L1 expression, clinicians should use nivolumab or atezolizumab. All immune checkpoint therapy is recommended alone plus in the absence of contraindications. For patients who received a prior first-line immune checkpoint inhibitor, clinicians should offer standard chemotherapy. For patients who cannot receive immune checkpoint inhibitor after chemotherapy, docetaxel is recommended; in patients with nonsquamous NSCLC, pemetrexed is recommended. In patients with a sensitizing EGFR mutation, disease progression after first-line epidermal growth factor receptor tyrosine kinase inhibitor therapy, and T790M mutation, osimertinib is recommended; if NSCLC lacks the T790M mutation, then chemotherapy is recommended. Patients with ROS1 gene rearrangement without prior crizotinib may be offered crizotinib, or if they previously received crizotinib, they may be offered chemotherapy.

Role of Angiogenesis in the Etiology and Prevention of Ovarian Cancer

DTIC Science & Technology

2004-10-01

sequences of peptides were confirmed by N-terminal sequencing and viewer ( Molecular Simulations , Inc.) and were analyzed using X-PLOR mass spectrometry...clinical benefit seen in trials using Avastin (anti-VEGF humanized antibody) and chemotherapy. We are currently pursuing the molecular mechanism involved in...and ovarian cancer. Invited speaker. ASCO Molecular Therapeutics symposium. Nov. 8-10, 2002, San Diego, CA. 13. I. V. Subramanian, R. Ghebre, Y

Expanding Public-Private Collaborations to Enhance Cancer Drug Development: A Report of the Institute of Medicine’s Workshop Series, “Implementing a National Cancer Clinical Trials System for the 21st Century”

PubMed Central

Canetta, Renzo; Nass, Sharyl J.

2014-01-01

Since their inception in the 1950s, the National Cancer Institute-funded cancer cooperative groups have been important contributors to cancer clinical and translational research. In 2010, a committee appointed by the Institute of Medicine (IOM) of the National Academy of Sciences completed a consensus review on the status of the U.S. publicly funded cancer clinical trials system. This report identified a need to reinvigorate the cooperative groups and provided recommendations for improving their effectiveness. Follow-up workshops to monitor progress were conducted by the IOM’s National Cancer Policy Forum and the American Society of Clinical Oncology (ASCO) in 2011 and 2013. One of the key recommendations of the IOM report was a call for greater collaboration among stakeholders in cancer research. In particular, more active engagement and better alignment of incentives among the cooperative groups, the National Cancer Institute, the U.S. Food and Drug Administration, and the biopharmaceutical industry were identified as essential to achieving the promise of oncology drug development. This review, based on presentations and discussion during the IOM-ASCO workshops, outlines the progress and remaining challenges of these collaborations. PMID:25326161

Expanding public-private collaborations to enhance cancer drug development: a report of the Institute of Medicine's workshop series, "Implementing a National Cancer Clinical Trials System for the 21st Century".

PubMed

Bertagnolli, Monica M; Canetta, Renzo; Nass, Sharyl J

2014-11-01

Since their inception in the 1950s, the National Cancer Institute-funded cancer cooperative groups have been important contributors to cancer clinical and translational research. In 2010, a committee appointed by the Institute of Medicine (IOM) of the National Academy of Sciences completed a consensus review on the status of the U.S. publicly funded cancer clinical trials system. This report identified a need to reinvigorate the cooperative groups and provided recommendations for improving their effectiveness. Follow-up workshops to monitor progress were conducted by the IOM's National Cancer Policy Forum and the American Society of Clinical Oncology (ASCO) in 2011 and 2013. One of the key recommendations of the IOM report was a call for greater collaboration among stakeholders in cancer research. In particular, more active engagement and better alignment of incentives among the cooperative groups, the National Cancer Institute, the U.S. Food and Drug Administration, and the biopharmaceutical industry were identified as essential to achieving the promise of oncology drug development. This review, based on presentations and discussion during the IOM-ASCO workshops, outlines the progress and remaining challenges of these collaborations. ©AlphaMed Press.

The Role of Congress in the Strategic Posture of the United States, 1980-1990: Force Modernization and SDI

DTIC Science & Technology

2010-02-01

for the program was a fiction. The senator “salute[ d ] the Commission for shooting down essentially the ‘window of vulnerability’ bugaboo that has...Bill Hostyn (ASCO) 2. TYPE OF MATERIAL: [8) PAPER D PRESENTATION D ABSTRACT D OTHER SUSPENSE: DATE: DATE: DATE: 3. OVERALL CLASSIFICATION: [8...Authority § Proprietary Information Test and Evaluation Software Documentation Critical Technology Defense Threat Reduction Agency D C

American Society of Clinical Oncology 2006 update of the breast cancer follow-up and management guidelines in the adjuvant setting.

PubMed

Khatcheressian, James L; Wolff, Antonio C; Smith, Thomas J; Grunfeld, Eva; Muss, Hyman B; Vogel, Victor G; Halberg, Francine; Somerfield, Mark R; Davidson, Nancy E

2006-11-01

To update the 1999 American Society of Clinical Oncology (ASCO) guideline on breast cancer follow-up and management in the adjuvant setting. An ASCO Expert Panel reviewed pertinent information from the literature through March 2006. More weight was given to studies that tested a hypothesis directly relating testing to one of the primary outcomes in a randomized design. The evidence supports regular history, physical examination, and mammography as the cornerstone of appropriate breast cancer follow-up. All patients should have a careful history and physical examination performed by a physician experienced in the surveillance of cancer patients and in breast examination. Examinations should be performed every 3 to 6 months for the first 3 years, every 6 to 12 months for years 4 and 5, and annually thereafter. For those who have undergone breast-conserving surgery, a post-treatment mammogram should be obtained 1 year after the initial mammogram and at least 6 months after completion of radiation therapy. Thereafter, unless otherwise indicated, a yearly mammographic evaluation should be performed. Patients at high risk for familial breast cancer syndromes should be referred for genetic counseling. The use of CBCs, chemistry panels, bone scans, chest radiographs, liver ultrasounds, computed tomography scans, [18F]fluorodeoxyglucose-positron emission tomography scanning, magnetic resonance imaging, or tumor markers (carcinoembryonic antigen, CA 15-3, and CA 27.29) is not recommended for routine breast cancer follow-up in an otherwise asymptomatic patient with no specific findings on clinical examination. Careful history taking, physical examination, and regular mammography are recommended for appropriate detection of breast cancer recurrence.

ASCO 2017 meeting summary: updates to practice-changing studies in untreated non-Hodgkin lymphoma

PubMed Central

Laneuville, P.; Larouche, J.F.; Tosikyan, A.; Christofides, A.

2017-01-01

The 2017 annual meeting of the American Society of Clinical Oncology took place in Chicago, Illinois, 2–6 June. At the meeting, results from key studies in the first-line treatment of indolent non-Hodgkin lymphoma (inhl) were presented. Of those studies, two were selected for oral presentations: 9-year follow-up data from the stil nhl1 trial, which compared the efficacy and safety of bendamustine plus rituximab (br) with those of rituximab plus cyclophosphamide–vincristine–prednisone–doxorubicin (r-chop); and 5-year follow-up data from the bright study, which compared br with r-chop and r-cvp (rituximab plus cyclophosphamide–vincristine–prednisone) combined. Our meeting report describes the foregoing studies and includes interviews with key investigators, plus commentaries from three Quebec hematologists on the potential effects for Canadian practice.

Advanced Technology Acquisition Strategies of the People’s Republic of China

DTIC Science & Technology

2010-09-01

identify, plan, and persuasively communicate what is needed in the near-term to achieve the longer-term goals inherent in the Agency’s mission. ASCO...Over several decades, Chinese leaders have pursued C DEFENSE THREAT REDUCTION AGENGY – ADVANCED SYSTEMS AND CONCEPTS OFFICE 2 what has...mathematics, astronomy , manufacturing, and many other facets of economic and cultural development. The “four great inventions” (sì dà fā míng) of

Current status of 5α-reductase inhibitors in prostate disease management.

PubMed

Kang, Dong Il; Chung, Jae Il

2013-04-01

The key enzyme in the androgen synthesis and androgen receptor pathways is 5α-reductase (5-AR), which occurs as three isoenzymes. Types I and II 5-ARs the most important clinically, and two different 5-AR inhibitors (5-ARIs), finasteride and dutasteride, have been developed. Several urology associations have recommended and upgraded the use of 5-ARIs for an enlarged prostate with lower urinary tract symptoms. In the Prostate Cancer Prevention Trial and the Reduction by Dutasteride of Prostate Cancer Events Trial, 5-ARIs reduced the incidence of low-grade prostate cancer. However, despite the documented reductions in the overall incidence of prostate cancer, 5-ARIs are at the center of a dispute. The American Society of Clinical Oncology (ASCO) and the American Urology Association (AUA) presented clinical guidelines for the use of 5-ARIs for chemoprevention of prostate cancer in 2008. However, ASCO/AUA has eliminated these from the main "Clinical Guidelines" in 2012, because the U.S. Food and Drug Administration denied a supplemental New Drug Application for the use of dutasteride for prostate cancer chemoprevention. The 5-ARIs can also be used to manage hemospermia and prostatic hematuria, and to prevent intraoperative bleeding, although there is insufficient evidence for a standard strategy. This review summarizes the current use of 5-ARIs for prostate disease, including benign prostate hyperplasia, prostate cancer, prostate-related bleeding, and hemospermia.

Assessment of Risk Evaluation and Mitigation Strategies in Oncology: Summary of the Oncology Risk Evaluation and Mitigation Strategies Workshop

PubMed Central

Frame, James N.; Jacobson, Joseph O.; Vogel, Wendy H.; Griffith, Niesha; Wariabharaj, Darshan; Garg, Rekha; Zon, Robin; Stephens, Cyntha L.; Bialecki, Alison M.; Bruinooge, Suanna S.; Allen, Steven L.

2013-01-01

To address oncology community stakeholder concerns regarding implementation of the Risk Evaluation and Mitigation Strategies (REMS) program, ASCO sponsored a workshop to gather REMS experiences from representatives of professional societies, patient organizations, pharmaceutical companies, and the US Food and Drug Administration (FDA). Stakeholder presentations and topical panel discussions addressed REMS program development, implementation processes, and practice experiences, as well as oncology drug safety processes. A draft REMS decision tool prepared by the ASCO REMS Steering Committee was presented for group discussion with facilitated, goal-oriented feedback. The workshop identified several unintended consequences resulting from current oncology REMS: (1) the release of personal health information to drug sponsors as a condition for gaining access to a needed drug; (2) risk information that is not tailored—and therefore not accessible—to all literacy levels; (3) exclusive focus on drug risk, thereby affecting patient-provider treatment discussion; (4) REMS elements that do not consider existing, widely practiced oncology safety standards, professional training, and experience; and (5) administrative burdens that divert the health care team from direct patient care activities and, in some cases, could limit patient access to important therapies. Increased provider and professional society participation should form the basis of ongoing and future REMS standardization discussions with the FDA to work toward overall improvement of risk communication. PMID:23814522

American Society of Clinical Oncology policy statement: oversight of clinical research.

PubMed

2003-06-15

Well-publicized lapses in the review or implementation of clinical research studies have raised public questions about the integrity of the clinical research process. Public trust in the integrity of research is critical not only for funding and participation in clinical trials but also for confidence in the treatments that result from the trials. The questions raised by these unfortunate cases pose an important opportunity to reassess the clinical trials oversight system to ensure the integrity of clinical research and the safety of those who enroll in clinical trials. Since its inception, the American Society of Clinical Oncology (ASCO) has worked for the advancement of cancer treatments through clinical research and to help patients gain prompt access to scientifically excellent and ethically unimpeachable clinical trials. As an extension of its mission, ASCO is affirming with this policy statement the critical importance of a robust review and oversight system to ensure that clinical trials participants give fully informed consent and that their safety is a top priority. Ensuring the integrity of research cannot be stressed enough because of its seminal connection to the advancement of clinical cancer treatment. The overall goal of this policy is to enhance public trust in the cancer clinical trials process. To achieve this, the following elements are essential: 1. Ensure safety precautions for clinical trial participants and their fully informed consent. 2. Ensure the validity and integrity of scientific research. 3. Enhance the educational training of clinical scientists and research staff to ensure the highest standards of research conduct. 4. Promote accountability and responsibility among all those involved in clinical research (not just those serving on institutional review boards [IRBs], but also institutional officials, researchers, sponsors, and participants) and ensure support for an effective oversight process. 5. Enhance the professional and public understanding of clinical research oversight. 6. Enhance the efficiency and cost-effectiveness of the clinical research oversight system. This policy statement makes recommendations in several areas that serve as principles to support an improved system of oversight for clinical research. ASCO will work with all parties involved in the clinical research system to develop the steps necessary to implement these recommendations. Centralized Trial Review: A large percentage of oncology clinical trials are coordinated through the National Cancer Institute's (NCI) system of cooperative groups, which already incorporates centralized scientific review. As such, there is a tremendous opportunity to employ a centralized mechanism to provide ethical review by highly trained IRB members, allowing local IRBs to take advantage of the financial and time efficiencies that central review provides. Centralized review boards (CRBs) would also contribute consistency and efficiency to the process. Once successfully completed, the review would represent an approval to open the protocol at all of the institutions that have subscribed to the centralized review system. Local IRBs would be able to devote time usually spent on initial review to ongoing monitoring of the trial taking place at their institution. Considering the enormous size and complexity of the clinical research enterprise, ASCO envisions multiple CRBs, which could be distributed as regional review boards. Central review will use a single protocol and consent form, and monitor and evaluate adverse events (AEs) on a global basis, eliminating many of the time-consuming steps for the local IRB. Global monitoring and assessment of AEs has real potential to enhance trial participants' safety by giving local institutions more information on the overall trial and enabling them to devote more time to ongoing review of the trial onsite. Use of a CRB also has real potential to reduce the costs of clinical trial oversight by allowing local IRBs to eliminate the costs of initial review. These efficiencies will likely lead to institutions redirecting funds toward monitoring ongoing trials. Although a CRB has potential to improve the efficiency of the process, a CRB could also have tremendous ability to delay valuable trials. Checks and balances must be included in the newly devised system to ensure timely review and appeals of CRB actions. ASCO proposes the advent of a new pilot program for centralizing review of clinical trials. It requires clear engagement of all stakeholders in planning the experiment, clear articulation of the goals, and assurance of federal regulatory protection for institutions choosing to participate. If successful, this CRB pilot project could be expanded to include multi-institutional industry-sponsored research. Education and Training:Education and training are critical to the ultimate success of an improved oversight system. All members of the research team should receive comprehensive education on conducting scientifically and ethically valid clinical research. The curriculum should also include information on the prevailing local and federal regulations that pertain to the clinical trials process. IRB members should also receive ongoing education and training in the review of clinical research protocols. IRB training should pay particular attention to nonscientific members to give them the tools necessary to speak on behalf of research participants. ASCO should develop a curriculum that focuses on the proper conduct of human research and emphasize ethically sound clinical research in the context of its Annual Meeting. Informed Consent: Investigators and review boards have specific roles to play in ensuring the education of trial participants through the informed consent process, both when they are considering trial enrollment and as they participate in the trial. Review boards and investigators should focus primarily on the informed consent process, rather than the informed consent documents. Federal Oversight: The federal government has an important role to play in the oversight of clinical research. This role should be expanded to cover all research, not just that which is funded by the federal government or conducted with the oversight of the Food and Drug Administration (FDA). The Department of Health and Human Services (HHS) Office for Human Research Protections (OHRP) and the FDA should provide clear regulatory support and guidance for local institutions that choose to employ a CRB. In the case of the pilot CRB discussed in this policy statement, it should serve as the preferred option for the cancer cooperative group clinical trials. Ideally, the federal government should unify and streamline its regulations for the oversight of clinical research. Resources Supporting Clinical Research Infrastructure:An effective oversight process demands the highest quality scientific and ethical review and onsite monitoring of the safety of trial participants. This can only be accomplished by the involvement of an experienced IRB that receives funding, resources, and institutional support enabling it to fulfill its mandate. Critical to the integrity of research is the absence of bias in the process. ASCO strongly recommends the adoption of standards for the identification, management, and, where appropriate, elimination of conflicts of interests, whether they are actual, potential, or apparent.

The Impact of 2013 Updated ASCO/CAP HER2 Guidelines on the Diagnosis and Management of Invasive Breast Cancer: A Single-Center Study of 1739 Cases.

PubMed

Zhang, Xiaofei; Bleiweiss, Ira; Jaffer, Shabnam; Nayak, Anupma

2017-10-01

The purpose of this study was to determine the impact of revised ASCO/CAP 2013 HER2 guidelines on the clinical practice of pathologists and oncologists. Retrospective analysis of 1739 patients with invasive breast carcinoma who underwent reflex HER2 (fluorescence in situ hybridization [FISH]) testing, using both 2007 and 2013 guidelines (2007-2014). Using 2013 guidelines, 255 (15%; 95% confidence interval [CI], 13%-16%) cases were classified as HER2 + as opposed to 186 (11%; 95% CI, 9%-12%) by 2007 guidelines (odds ratio [OR] 1.4; 95% CI, 1.2-1.8; P = .0005). Sixty-nine cases equivocal by 2007 guidelines (12% of all equivocal cases) were converted to HER2 + by 2013 guidelines. Sixty-two of these 69 cases shifted from HER2 equivocal to positive due to change in FISH ratio cutoff from 2.2 to 2.0. Six cases had FISH ratio < 2.0 but immunohistochemistry (IHC) score 3+ in 10% to 30% of tumor cells. One case had FISH ratio of 2.0 and IHC score 3+ in 10% to 30% of tumor cells. FISH and IHC test results were discordant in 5% (95% CI, 4%-6%) of cases using 2013 guidelines. No increase in HER2 FISH equivocal cases was observed. Reflex FISH testing of all IHC 1+ cases at our institution additionally detected 58 patients (5%; 95% CI, 4%-6%) with HER2 amplification. The 2013 guidelines increase the detection of HER2 + cases, without introducing significant difference in discordance rate of the IHC and FISH assays. Inclusion of HER2 copy number criterion does not increase the number of FISH equivocal cases in our cohort. We recommend IHC 1+ cases should be offered reflex FISH testing because failure to test them will miss a small number (5%) of potentially treatable cases. Copyright © 2017 Elsevier Inc. All rights reserved.

A Randomized Phase 2 Trial of 177Lu Radiolabeled Anti-PSMA Biochemically Monoclonal Antibody J591 in Patients with High-Risk Castrate, Biochemically Relapsed Prostate Cancer

DTIC Science & Technology

2010-09-01

relapsed prostate cancer (PC) after local therapy. J Clin Oncol 28: 15s, 2010 (suppl; Abstr TPS248) Presentation: Poster presentation, 2010 ASCO...Annual Meeting V. Conclusions Biochemical relapse is common after local therapy for prostate cancer. Based on the physical properties of 177Lu...ketoconazole in patients (pts) with high-risk castrate biochemically relapsed prostate cancer (PC) after local therapy. S. T. Tagawa, J. Osborne, P. J

Translational challenges from the 2014 Gastrointestinal Cancers Symposium: toward a true tailored therapy through effective research.

PubMed

Aprile, Giuseppe; Giuliani, Francesco; Cordio, Stefano; Sartore-Bianchi, Andrea; Bencardino, Katia; Ongaro, Elena; Martines, Concetta; Giampieri, Riccardo; Bordonaro, Roberto; Siena, Salvatore; Cascinu, Stefano; Scartozzi, Mario

2014-05-01

Gastrointestinal Cancers Symposium 2014, San Francisco, CA, USA, 16-18 January 2014. The Gastrointestinal Cancers Symposium represents an indisputable occasion for sharing results and research opportunities for investigators around the globe. Across the years along with clinical trials presentations the meeting increasingly acquired a distinct role as a scientific arena for translational research. Also, this year the need for predictive markers for first-generation targeted agents and research about novel biologically driven therapeutic options characterized most of the studies presented. We focus here on reports from the 2014 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium indicating an opportunity for biological selection of either the pharmacological target or the patient population in order to enhance clinical outcome.

Human epidermal growth factor receptor 2 assessment in a case-control study: comparison of fluorescence in situ hybridization and quantitative reverse transcription polymerase chain reaction performed by central laboratories.

PubMed

Baehner, Frederick L; Achacoso, Ninah; Maddala, Tara; Shak, Steve; Quesenberry, Charles P; Goldstein, Lynn C; Gown, Allen M; Habel, Laurel A

2010-10-01

The optimal method to assess human epidermal growth factor receptor 2 (HER2) status remains highly controversial. Before reporting patient HER2 results, American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines mandate that laboratories demonstrate ≥ 95% concordance to another approved laboratory or methodology. Here, we compare central laboratory HER2 assessed by fluorescence in situ hybridization (FISH) and quantitative reverse transcriptase polymerase chain reaction (RT-PCR) using Oncotype DX in lymph node-negative, chemotherapy-untreated patients from a large Kaiser Permanente case-control study. Breast cancer specimens from the Kaiser-Genomic Health study were examined. Central FISH assessment of HER2 amplification and polysomy 17 was conducted by PhenoPath Laboratories (ratios > 2.2, 1.8 to 2.2, and < 1.8 define HER2 positive, HER2 equivocal, and HER2 negative, respectively). HER2 expression by RT-PCR was conducted using Oncotype DX by Genomic Health (normalized expression units ≥ 11.5, 10.7 to < 11.5, and < 10.7 define HER2 positive, HER2 equivocal, and HER2 negative, respectively). Concordance analyses followed ASCO/CAP guidelines. HER2 concordance by central FISH and central RT-PCR was 97% (95% CI, 96% to 99%). Twelve percent (67 of 568 patients) and 11% (60 of 568 patients) of patients were HER2 positive by RT-PCR and FISH, respectively. HER2-positive patients had increased odds of dying from breast cancer compared with HER2-negative patients. Polysomy 17 was demonstrated in 12.5% of all patients and 33% of FISH-positive patients. Nineteen of 20 FISH-positive patients with polysomy 17 were also RT-PCR HER2 positive. Although not statistically significantly different, HER2-positive/polysomy 17 patients tended to have the worst prognosis, followed by HER2-positive/eusomic, HER2-negative/polysomy 17, and HER2-negative/eusomic patients. There is a high degree of concordance between central FISH and quantitative RT-PCR using Oncotype DX for HER2 status, and the assay warrants additional study in a trastuzumab-treated population.

Breast cancer: a global perspective.

PubMed

Collyar, D E

2001-09-15

The 2001 American Society of Clinical Oncology (ASCO) International Symposium, Breast Cancer: A Global Perspective, was conducted by members of the ASCO International Committee and additional speakers from around the world. An interactive format was chosen to: (1) learn how patterns of incidence, epidemiology, and causal biology relate to breast cancer around the world; (2) discuss the challenges in screening, diagnosis, and treatment of breast cancer, as well as its socioeconomic impact in various regions; (3) describe international differences in approach to and management of advanced breast cancer; and (4) discuss treatment in terms of hormone response, clinical research, and drug metabolism. After a brief introduction, each speaker gave an overview of breast cancer challenges and issues in their country, and discussed how the following case might be diagnosed and treated: A 44-year-old mother who presents with a finding of a painless breast lump and no prior history of breast masses, trauma, or surgery. Comments from a patient perspective were then presented, followed by a panel discussion and closing remarks. Co-chairs of this Symposium included Deborah Collyar (President, PAIR-Patient Advocates in Research) and Elizabeth Eisenhauer, MD (Director, Investigational New Drug Program, National Cancer Institute of Canada Clinical Trials Group). Speakers included Gilberto Schwartsmann, MD (South America), Monica Morrow, MD (North America), Daniel Vorobiof, MD (South Africa), Rakesh Chopra, MD (India), Klaus Hoeffken, MD (Eastern Europe), Russell Basser, MD (Australia), Susan Matsuko Shinigawa (patient perspective), and Larry Norton, MD (closing remarks).

Antiemetics: American Society of Clinical Oncology Clinical Practice Guideline Update

PubMed Central

Basch, Ethan; Prestrud, Ann Alexis; Hesketh, Paul J.; Kris, Mark G.; Feyer, Petra C.; Somerfield, Mark R.; Chesney, Maurice; Clark-Snow, Rebecca Anne; Flaherty, Anne Marie; Freundlich, Barbara; Morrow, Gary; Rao, Kamakshi V.; Schwartz,, Rowena N.; Lyman, Gary H.

2011-01-01

Purpose To update the American Society of Clinical Oncology (ASCO) guideline for antiemetics in oncology. Methods A systematic review of the medical literature was completed to inform this update. MEDLINE, the Cochrane Collaboration Library, and meeting materials from ASCO and the Multinational Association for Supportive Care in Cancer were all searched. Primary outcomes of interest were complete response and rates of any vomiting or nausea. Results Thirty-seven trials met prespecified inclusion and exclusion criteria for this systematic review. Two systematic reviews from the Cochrane Collaboration were identified; one surveyed the pediatric literature. The other compared the relative efficacy of the 5-hydroxytryptamine-3 (5-HT3) receptor antagonists. Recommendations Combined anthracycline and cyclophosphamide regimens were reclassified as highly emetic. Patients who receive this combination or any highly emetic agents should receive a 5-HT3 receptor antagonist, dexamethasone, and a neurokinin 1 (NK1) receptor antagonist. A large trial validated the equivalency of fosaprepitant, a single-day intravenous formulation, with aprepitant; either therapy is appropriate. Preferential use of palonosetron is recommended for moderate emetic risk regimens, combined with dexamethasone. For low-risk agents, patients can be offered dexamethasone before the first dose of chemotherapy. Patients undergoing high emetic risk radiation therapy should receive a 5-HT3 receptor antagonist before each fraction and for 24 hours after treatment and may receive a 5-day course of dexamethasone during fractions 1 to 5. The Update Committee noted the importance of continued symptom monitoring throughout therapy. Clinicians underestimate the incidence of nausea, which is not as well controlled as emesis. PMID:21947834

Breast cancer follow-up and management after primary treatment: American Society of Clinical Oncology clinical practice guideline update.

PubMed

Khatcheressian, James L; Hurley, Patricia; Bantug, Elissa; Esserman, Laura J; Grunfeld, Eva; Halberg, Francine; Hantel, Alexander; Henry, N Lynn; Muss, Hyman B; Smith, Thomas J; Vogel, Victor G; Wolff, Antonio C; Somerfield, Mark R; Davidson, Nancy E

2013-03-01

To provide recommendations on the follow-up and management of patients with breast cancer who have completed primary therapy with curative intent. To update the 2006 guideline of the American Society of Clinical Oncology (ASCO), a systematic review of the literature published from March 2006 through March 2012 was completed using MEDLINE and the Cochrane Collaboration Library. An Update Committee reviewed the evidence to determine whether the recommendations were in need of updating. There were 14 new publications that met inclusion criteria: nine systematic reviews (three included meta-analyses) and five randomized controlled trials. After its review and analysis of the evidence, the Update Committee concluded that no revisions to the existing ASCO recommendations were warranted. Regular history, physical examination, and mammography are recommended for breast cancer follow-up. Physical examinations should be performed every 3 to 6 months for the first 3 years, every 6 to 12 months for years 4 and 5, and annually thereafter. For women who have undergone breast-conserving surgery, a post-treatment mammogram should be obtained 1 year after the initial mammogram and at least 6 months after completion of radiation therapy. Thereafter, unless otherwise indicated, a yearly mammographic evaluation should be performed. The use of complete blood counts, chemistry panels, bone scans, chest radiographs, liver ultrasounds, pelvic ultrasounds, computed tomography scans, [(18)F]fluorodeoxyglucose-positron emission tomography scans, magnetic resonance imaging, and/or tumor markers (carcinoembryonic antigen, CA 15-3, and CA 27.29) is not recommended for routine follow-up in an otherwise asymptomatic patient with no specific findings on clinical examination.

Electronic nicotine delivery systems: a policy statement from the American Association for Cancer Research and the American Society of Clinical Oncology.

PubMed

Brandon, Thomas H; Goniewicz, Maciej L; Hanna, Nasser H; Hatsukami, Dorothy K; Herbst, Roy S; Hobin, Jennifer A; Ostroff, Jamie S; Shields, Peter G; Toll, Benjamin A; Tyne, Courtney A; Viswanath, Kasisomayajula; Warren, Graham W

2015-02-01

Combustible tobacco use remains the number one preventable cause of disease, disability, and death in the United States. Electronic nicotine delivery systems (ENDS), which include e-cigarettes, are devices capable of delivering nicotine in an aerosolized form. ENDS use by both adults and youth has increased rapidly, and some have advocated these products could serve as harm-reduction devices and smoking cessation aids. ENDS may be beneficial if they reduce smoking rates or prevent or reduce the known adverse health effects of smoking. However, ENDS may also be harmful, particularly to youth, if they increase the likelihood that nonsmokers or formers smokers will use combustible tobacco products or if they discourage smokers from quitting. The American Association for Cancer Research (AACR) and the American Society of Clinical Oncology (ASCO) recognize the potential ENDS have to alter patterns of tobacco use and affect the public's health; however, definitive data are lacking. AACR and ASCO recommend additional research on these devices, including assessing the health impacts of ENDS, understanding patterns of ENDS use, and determining what role ENDS have in cessation. Key policy recommendations include supporting federal, state, and local regulation of ENDS; requiring manufacturers to register with the FDA and report all product ingredients, requiring childproof caps on ENDS liquids, and including warning labels on products and their advertisements; prohibiting youth-oriented marketing and sales; prohibiting child-friendly ENDS flavors; and prohibiting ENDS use in places where cigarette smoking is prohibited. ©2015 American Association for Cancer Research and American Society of Clinical Oncology.

Feasibility of a Centralized Clinical Trials Coverage Analysis: A Joint Initiative of the American Society of Clinical Oncology and the National Cancer Institute.

PubMed

Szczepanek, Connie M; Hurley, Patricia; Good, Marjorie J; Denicoff, Andrea; Willenberg, Kelly; Dawson, Casey; Kurbegov, Dax

2017-06-01

Clinical trial billing compliance is a challenge that is faced by overburdened clinical trials sites. The requirements place institutions and research sites at increased potential for financial risk. To reduce their risk, sites develop a coverage analysis (CA) before opening each trial. For multisite trials, this translates into system-wide redundancies, inconsistencies, trial delays, and potential costs to sites and patients. These factors exacerbate low accrual rates to cancer clinical trials. ASCO and the National Cancer Institute (NCI) collaborated to address this problem. An ASCO Research Community Forum working group proposed the concept of providing centrally developed CAs to research sites at protocol startup. The group collaborated with NCI and billing compliance experts to hold a symposium for key stakeholders to share knowledge, build skills, provide tools to conduct centralized CAs, and strategize about the next steps. Forty-eight attendees, who represented a range of stakeholders, participated in the symposium. As a result of this initiative, NCI directed the Cancer Trials Support Unit to convene a working group with NCI's National Clinical Trials Network (NCTN) and Community Oncology Research Program (NCORP) to develop tools and processes for generating CAs for their trials. A CA template with core elements was developed and is being adapted in a pilot project across NCTN Group and NCORP Research Bases. Centralized CAs for multisite trials-using standardized tools and templates-are feasible. They have the potential to reduce risk for patients and sites, forecast budget needs, and help decrease trial startup times that impede patient access and accrual to clinical trials.

Clinical practice guidelines in breast cancer

PubMed Central

Tyagi, N. Kumar; Dhesy-Thind, S.

2018-01-01

Background A number of clinical practice guidelines (cpgs) concerning breast cancer (bca) screening and management are available. Here, we review the strengths and weaknesses of cpgs from various professional organizations and consensus groups with respect to their methodologic quality, recommendations, and implementability. Methods Guidelines from four groups were reviewed with respect to two clinical scenarios: adjuvant ovarian function suppression (ofs) in premenopausal women with early-stage estrogen receptor–positive bca, and use of sentinel lymph node biopsy (slnb) after neoadjuvant chemotherapy (nac) for locally advanced bca. Guidelines from the American Society of Clinical Oncology (asco); Cancer Care Ontario’s Program in Evidence Based Care (cco’s pebc); the U.S. National Comprehensive Cancer Network (nccn); and the St. Gallen International Breast Cancer Consensus Conference were reviewed by two independent assessors. Guideline methodology and applicability were evaluated using the agree ii tool. Results The quality of the cpgs was greatest for the guidelines developed by asco and cco’s pebc. The nccn and St. Gallen guidelines were found to have lower scores for methodologic rigour. All guidelines scored poorly for applicability. The recommendations for ofs were similar in three guidelines. Recommendations by the various organizations for the use of slnb after nac were contradictory. Conclusions Our review demonstrated that cpgs can be heterogeneous in methodologic quality. Low-quality cpg implementation strategies contribute to low uptake of, and adherence to, bca cpgs. Further research examining the barriers to recommendations—such as intrinsic guideline characteristics and the needs of end users—is required. The use of bca cpgs can improve the knowledge-to-practice gap and patient outcomes.

American Society of Clinical Oncology Policy Statement: The Role of the Oncologist in Cancer Prevention and Risk Assessment

PubMed Central

Zon, Robin T.; Goss, Elizabeth; Vogel, Victor G.; Chlebowski, Rowan T.; Jatoi, Ismail; Robson, Mark E.; Wollins, Dana S.; Garber, Judy E.; Brown, Powel; Kramer, Barnett S.

2009-01-01

Oncologists have a critical opportunity to utilize risk assessment and cancer prevention strategies to interrupt the initiation or progression of cancer in cancer survivors and individuals at high risk of developing cancer. Expanding knowledge about the natural history and prognosis of cancers positions oncologists to advise patients regarding the risk of second malignancies and treatment-related cancers. In addition, as recognized experts in the full spectrum of cancer care, oncologists are afforded opportunities for involvement in community-based cancer prevention activities. Although oncologists are currently providing many cancer prevention and risk assessment services to their patients, economic barriers exist, including inadequate or lack of insurance, that may compromise uniform patient access to these services. Additionally, insufficient reimbursement for existing and developing interventions may discourage patient access to these services. The American Society of Clinical Oncology (ASCO), the medical society representing cancer specialists involved in patient care and clinical research, is committed to supporting oncologists in their wide-ranging involvement in cancer prevention. This statement on risk assessment and prevention counseling, although not intended to be a comprehensive overview of cancer prevention describes the current role of oncologists in risk assessment and prevention; provides examples of risk assessment and prevention activities that should be offered by oncologists; identifies potential opportunities for coordination between oncologists and primary care physicians in prevention education and coordination of care for cancer survivors; describes ASCO's involvement in education and training of oncologists regarding prevention; and proposes improvement in the payment environment to encourage patient access to these services. PMID:19075281

American Society of Clinical Oncology National Census of Oncology Practices: Preliminary Report

PubMed Central

Forte, Gaetano J.; Hanley, Amy; Hagerty, Karen; Kurup, Anupama; Neuss, Michael N.; Mulvey, Therese M.

2013-01-01

In response to reports of increasing financial and administrative burdens on oncology practices and a lack of systematic information related to these issues, American Society of Clinical Oncology (ASCO) leadership started an effort to collect key practice-level data from all oncology practices in the United States. The result of the effort is the ASCO National Census of Oncology Practices (Census) launched in June 2012. The initial Census work involved compiling an inventory of oncology practices from existing lists of oncology physicians in the United States. A comprehensive, online data collection instrument was developed, which covered a number of areas, including practice characteristics (staffing configuration, organizational structure, patient mix and volume, types of services offered); organizational, staffing, and service changes over the past 12 months; and an assessment of the likelihood that the practice would experience organizational, staffing, and service changes in the next 12 months. More than 600 practices participated in the Census by providing information. In this article, we present preliminary highlights from the data gathered to date. We found that practice size was related to having experienced practice mergers, hiring additional staff, and increasing staff pay in the past 12 months, that geographic location was related to having experienced hiring additional staff, and that practices in metropolitan areas were more likely to have experienced practice mergers in the past 12 months than those in nonmetropolitan areas. We also found that practice size and geographic location were related to higher likelihoods of anticipating practice mergers, sales, and purchases in the future. PMID:23633966

Rat optic nerve head anatomy within 3D histomorphometric reconstructions of normal control eyes.

PubMed

Pazos, Marta; Yang, Hongli; Gardiner, Stuart K; Cepurna, William O; Johnson, Elaine C; Morrison, John C; Burgoyne, Claude F

2015-10-01

The purpose of this study is to three-dimensionally (3D) characterize the principal macroscopic and microscopic relationships within the rat optic nerve head (ONH) and quantify them in normal control eyes. Perfusion-fixed, trephinated ONH from 8 normal control eyes of 8 Brown Norway Rats were 3D histomorphometrically reconstructed, visualized, delineated and parameterized. The rat ONH consists of 2 scleral openings, (a superior neurovascular and inferior arterial) separated by a thin connective tissue strip we have termed the "scleral sling". Within the superior opening, the nerve abuts a prominent extension of Bruch's Membrane (BM) superiorly and is surrounded by a vascular plexus, as it passes through the sclera, that is a continuous from the choroid into and through the dural sheath and contains the central retinal vein (CRV), (inferiorly). The inferior scleral opening contains the central retinal artery and three long posterior ciliary arteries which obliquely pass through the sclera to obtain the choroid. Bruch's Membrane Opening (BMO) is irregular and vertically elongated, enclosing the nerve (superiorly) and CRV and CRA (inferiorly). Overall mean BMO Depth, BMO Area, Choroidal Thickness and peripapillary Scleral Thickness were 29 μm, 56.5 × 10(3) μm(2), 57 μm and 104 μm respectively. Mean anterior scleral canal opening (ASCO) and posterior scleral canal opening (PSCO) radii were 201 ± 15 μm and 204 ± 16 μm, respectively. Mean optic nerve area at the ASCO and PSCO were 46.3 × 10(3)±4.4 × 10(3) μm(2) and 44.1 × 10(3)±4.5 × 10(3) μm(2) respectively. In conclusion, the 3D complexity of the rat ONH and the extent to which it differs from the primate have been under-appreciated within previous 2D studies. Properly understood, these anatomic differences may provide new insights into the relative susceptibilities of the rat and primate ONH to elevated intraocular pressure. Copyright © 2015 Elsevier Ltd. All rights reserved.

On the chemical dynamics of extracellular polysaccharides in the high Arctic surface microlayer

NASA Astrophysics Data System (ADS)

Gao, Q.; Leck, C.; Rauschenberg, C.; Matrai, P. A.

2012-07-01

The surface microlayer (SML) represents a unique system of which the physicochemical characteristics may differ from those of the underlying subsurface seawater (SSW). Within the Arctic pack ice area, the SML has been characterized as enriched in small colloids of biological origin, resulting from extracellular polymeric secretions (EPS). During the Arctic Summer Cloud Ocean Study (ASCOS) in August 2008, particulate organic matter (POM, with size range > 0.22 μm) and dissolved organic matter (DOM, < 0.22 μm, obtained after filtration) samples were collected and chemically characterized from the SML and the corresponding SSW at an open lead centered at 87.5° N and 5° E. Total organic carbon was persistently enriched in the SML with a mean enrichment factor (EF) of 1.45 ± 0.41, whereas sporadic depletions of dissolved carbohydrates and amino acids were observed. Monosaccharide compositional analysis reveals that EPS in the Arctic lead was formed mainly of distinctive heteropolysaccharides, enriched in xylose, fucose and glucose. The mean concentrations of total hydrolysable neutral sugars in SSW were 94.9 ± 37.5 nM in high molecular weight (HMW) DOM (> 5 kDa) and 64.4 ± 14.5 nM in POM. The enrichment of polysaccharides in the SML appeared to be a common feature, with EFs ranging from 1.7 to 7.0 for particulate polysaccharides and 3.5 to 12.1 for polysaccharides in the HMW DOM fraction. A calculated monosaccharide yield suggests that polymers in the HMW DOM fraction were scavenged, without substantial degradation, into the SML. Bubble scavenging experiments showed that newly aggregated particles could be formed abiotically by coagulation of low molecular weight nanometer-sized gels. Aerosol particles, artificially generated by bubbling experiments, were enriched in polysaccharides by factors of 22-70, relative to the source seawater. We propose that bubble scavenging of surface-active polysaccharides could be one of the possible mechanisms for the enrichment of polysaccharides in the high Arctic open lead SML.

On the chemical dynamics of extracellular polysaccharides in the high Arctic surface microlayer

NASA Astrophysics Data System (ADS)

Gao, Q.; Leck, C.; Rauschenberg, C.; Matrai, P. A.

2012-01-01

The surface microlayer (SML) represents a unique system of which the physicochemical characteristics may differ from those of the underlying subsurface seawater (SSW). Within the Arctic pack ice area, the SML has been characterized as enriched in small colloids of biological origin, resulting from extracellular polymeric secretions (EPS). During the Arctic Summer Cloud-Ocean Study (ASCOS) in August 2008, particulate and dissolved organic matter (POM, DOM) samples were collected and chemically characterized from the SML and the corresponding SSW at an open lead centered at 87.5° N and 5° E. Total organic carbon was persistently enriched in the SML with a mean enrichment factor (EF) of 1.45 ± 0.41, whereas sporadic depletions of dissolved carbohydrates and amino acids were observed. Monosaccharide compositional analysis reveals that EPS in the Arctic lead was formed mainly of distinctive heteropolysaccharides, enriched in xylose, fucose and glucose. The mean concentrations of total hydrolysable neutral sugars in SSW were 94.9 ± 37.5 nM in high molecular weight (HMW) DOM and 64.4 ± 14.5 nM in POM. The enrichment of polysaccharides in the SML appeared to be a common feature, with EFs ranging from 1.7 to 7.0 for particulate polysaccharides and 3.5 to 12.1 for polysaccharides in the HMW DOM fraction. A calculated monosaccharide yield suggests that polymers in the HMW DOM fraction were scavenged, without substantial degradation, into the SML. Bubble scavenging experiments showed that newly aggregated particles could be formed abiotically by coagulation of low molecular weight nanometer-sized gels. Experimentally-generated aerosol particles were enriched in polysaccharides by factors of 22-70, relative to the source seawater. We propose that bubble scavenging of surface-active polysaccharides was one of the possible mechanisms for the enrichment of polysaccharides in the SML.

American Society of Clinical Oncology 2012 Annual Meeting: highlights from the gynecologic oncology track.

PubMed

Tewari, Krishnansu S

2012-11-01

The 2012 Annual Meeting of the American Society of Clinical Oncology (ASCO) was held in Chicago, June 1-5, 2011, and brought together more than 25,000 oncology professionals from a broad range of specialties to explore the theme, "Collaborating to Conquer Cancer". The Gynecologic Oncology Track had a strong international presence, with important clinical trials being presented from Japan, Germany, Norway, the United States, and others. This meeting report will highlight several phase 3 and phase 2 clinical trials as well as notable translational research endeavors and other selected abstracts.

American Society of Clinical Oncology guidance statement: the cost of cancer care.

PubMed

Meropol, Neal J; Schrag, Deborah; Smith, Thomas J; Mulvey, Therese M; Langdon, Robert M; Blum, Diane; Ubel, Peter A; Schnipper, Lowell E

2009-08-10

Advances in early detection, prevention, and treatment have resulted in consistently falling cancer death rates in the United States. In parallel with these advances have come significant increases in the cost of cancer care. It is well established that the cost of health care (including cancer care) in the United States is growing more rapidly than the overall economy. In part, this is a result of the prices and rapid uptake of new agents and other technologies, including advances in imaging and therapeutic radiology. Conventional understanding suggests that high prices may reflect the costs and risks associated with the development, production, and marketing of new drugs and technologies, many of which are valued highly by physicians, patients, and payers. The increasing cost of cancer care impacts many stakeholders who play a role in a complex health care system. Our patients are the most vulnerable because they often experience uneven insurance coverage, leading to financial strain or even ruin. Other key groups include pharmaceutical manufacturers that pass along research, development, and marketing costs to the consumer; providers of cancer care who dispense increasingly expensive drugs and technologies; and the insurance industry, which ultimately passes costs to consumers. Increasingly, the economic burden of health care in general, and high-quality cancer care in particular, will be less and less affordable for an increasing number of Americans unless steps are taken to curb current trends. The American Society of Clinical Oncology (ASCO) is committed to improving cancer prevention, diagnosis, and treatment and eliminating disparities in cancer care through support of evidence-based and cost-effective practices. To address this goal, ASCO established a Cost of Care Task Force, which has developed this Guidance Statement on the Cost of Cancer Care. This Guidance Statement provides a concise overview of the economic issues facing stakeholders in the cancer community. It also recommends that the following steps be taken to address immediate needs: recognition that patient-physician discussions regarding the cost of care are an important component of high-quality care; the design of educational and support tools for oncology providers to promote effective communication about costs with patients; and the development of resources to help educate patients about the high cost of cancer care to help guide their decision making regarding treatment options. Looking to the future, this Guidance Statement also recommends that ASCO develop policy positions to address the underlying factors contributing to the increased cost of cancer care. Doing so will require a clear understanding of the factors that drive these costs, as well as potential modifications to the current cancer care system to ensure that all Americans have access to high-quality, cost-effective care.

Tobacco control: reducing cancer incidence and saving lives. American Society of Clinical Oncology.

PubMed

1996-06-01

The American Society of Clinical Oncology (ASCO) supports the elimination of tobacco products. Toward that goal, ASCO urges the adoption of national policy that strengthens regulation of the sale, promotion, and distribution of such products. To reduce cancer mortality, our regulatory policies must recognize that the nicotine within tobacco is an addictive substance, the use of which leads to 30% of all cancer deaths and a total of 419,000 deaths each year. Tobacco-related advertising and promotion should be banned. At a minimum, national policies should: ban billboards; limit advertising to black and white text only; prohibit the sale or giveaway of products that contain tobacco brand names or logos; prohibit brand name sponsorship of sporting or entertainment events; and require stronger and more prominent warning labels on all tobacco products. Despite existing state laws prohibiting sale of tobacco products to minors, children are able to buy such products easily. National regulation of the sale and distribution of tobacco products is necessary to eliminate children's access to tobacco. Where sales are permitted, they should be limited to face-to-face purchases by individuals 18 and older. Vending machines and other means of distributing tobacco without a face-to-face purchase should be outlawed. To the extent tobacco sales are allowed to continue, the federal government should mandate that the tobacco industry contribute substantial funds for a national public education campaign to prevent young people from smoking and other tobacco use. ASCO has long advocated a substantial increase (in the range of $2) in the federal excise tax on cigarettes and other tobacco products- a measure known to decrease consumption, particularly among children. Revenue from a tax on tobacco products should be used to support retraining for tobacco farmers, biomedical research, health care delivery, and antitobacco education. United State trade policies should discourage the export of tobacco products and manufacturing to foreign markets. At a minimum, United States tobacco companies selling or manufacturing tobacco products in foreign markets that have not developed comparable health warning labels should be required to retain United States warning labels. Physicians, nurses, and other health care professionals-especially those in primary care disciplines-have the opportunity and responsibility to assist patients' efforts to quit tobacco use and to ensure that nonsmokers continue to avoid the addiction. Oncology specialists should discuss the causal relationship between tobacco use and cancer as well as a variety of other chronic diseases and assist, as required, the patient and family members to end tobacco dependency. In addition, health care professionals must advocate that public and private insurers be required to provide health care coverage for medically necessary interventions, such as counseling and nicotine transdermal systems.

Radiotherapy induced xerostomia: mechanisms, diagnostics, prevention and treatment--evidence based up to 2013.

PubMed

Kałużny, Jarosław; Wierzbicka, Małgorzata; Nogala, Hanna; Milecki, Piotr; Kopeć, Tomasz

2014-01-01

Definition and prevalence of xerostomia were shortly presented. Radiosensitivity of the salivary glands, mechanism, diagnostics, and possible prediction methods of the intensity of xerostomia in the pre-radiotherapy period are widely discussed. Prevention of xerostomia: salivary gland sparing radiotherapy, cytoprotective agents, preservation by stimulation with cholinergic muscarinic agonists, surgical transfer of submandibular glands according to ASCO Management Guidelines and Quality of Life Recommendations were cited. Oral Care Study Group (2010) therapeutic approaches for relieving xerostomia are referred. Current therapies, restricted to symptom relief such as oral hygiene with fluoride agents, antimicrobials to prevent dental caries, saliva substitutes to relieve symptoms, and sialogenic agents to stimulate saliva were also discussed. Copyright © 2013 Polish Otorhinolaryngology - Head and Neck Surgery Society. Published by Elsevier Urban & Partner Sp. z.o.o. All rights reserved.

Multidisciplinary Optimization of Oral Chemotherapy Delivery at the University of Wisconsin Carbone Cancer Center.

PubMed

Mulkerin, Daniel L; Bergsbaken, Jason J; Fischer, Jessica A; Mulkerin, Mary J; Bohler, Aaron M; Mably, Mary S

2016-10-01

Use of oral chemotherapy is expanding and offers advantages while posing unique safety challenges. ASCO and the Oncology Nursing Society jointly published safety standards for administering chemotherapy that offer a framework for improving oral chemotherapy practice at the University of Wisconsin Carbone Cancer Center. With the goal of improving safety, quality, and uniformity within our oral chemotherapy practice, we conducted a gap analysis comparing our practice against ASCO/Oncology Nursing Society guidelines. Areas for improvement were addressed by multidisciplinary workgroups that focused on education, workflows, and information technology. Recommendations and process changes included defining chemotherapy, standardizing patient and caregiver education, mandating the use of comprehensive electronic order sets, and standardizing documentation for dose modification. Revised processes allow pharmacists to review all orders for oral chemotherapy, and they support monitoring adherence and toxicity by using a library of scripted materials. Between August 2015 and January 2016, revised processes were implemented across the University of Wisconsin Carbone Cancer Center clinics. The following are key performance indicators: 92.5% of oral chemotherapy orders (n = 1,216) were initiated within comprehensive electronic order sets (N = 1,315), 89.2% compliance with informed consent was achieved, 14.7% of orders (n = 193) required an average of 4.4 minutes review time by the pharmacist, and 100% compliance with first-cycle monitoring of adherence and toxicity was achieved. We closed significant gaps between institutional practice and published standards for our oral chemotherapy practice and experienced steady improvement and sustainable performance in key metrics. We created an electronic definition of oral chemotherapies that allowed us to leverage our electronic health records. We believe our tools are broadly applicable.

Multidisciplinary Optimization of Oral Chemotherapy Delivery at the University of Wisconsin Carbone Cancer Center

PubMed Central

Bergsbaken, Jason J.; Fischer, Jessica A.; Mulkerin, Mary J.; Bohler, Aaron M.; Mably, Mary S.

2016-01-01

Purpose: Use of oral chemotherapy is expanding and offers advantages while posing unique safety challenges. ASCO and the Oncology Nursing Society jointly published safety standards for administering chemotherapy that offer a framework for improving oral chemotherapy practice at the University of Wisconsin Carbone Cancer Center. Methods: With the goal of improving safety, quality, and uniformity within our oral chemotherapy practice, we conducted a gap analysis comparing our practice against ASCO/Oncology Nursing Society guidelines. Areas for improvement were addressed by multidisciplinary workgroups that focused on education, workflows, and information technology. Recommendations and process changes included defining chemotherapy, standardizing patient and caregiver education, mandating the use of comprehensive electronic order sets, and standardizing documentation for dose modification. Revised processes allow pharmacists to review all orders for oral chemotherapy, and they support monitoring adherence and toxicity by using a library of scripted materials. Results: Between August 2015 and January 2016, revised processes were implemented across the University of Wisconsin Carbone Cancer Center clinics. The following are key performance indicators: 92.5% of oral chemotherapy orders (n = 1,216) were initiated within comprehensive electronic order sets (N = 1,315), 89.2% compliance with informed consent was achieved, 14.7% of orders (n = 193) required an average of 4.4 minutes review time by the pharmacist, and 100% compliance with first-cycle monitoring of adherence and toxicity was achieved. Conclusion: We closed significant gaps between institutional practice and published standards for our oral chemotherapy practice and experienced steady improvement and sustainable performance in key metrics. We created an electronic definition of oral chemotherapies that allowed us to leverage our electronic health records. We believe our tools are broadly applicable. PMID:27858570

Correlation between financial relationships with commercial interests and research prominence at an oncology meeting.

PubMed

Moy, Beverly; Bradbury, Angela R; Helft, Paul R; Egleston, Brian L; Sheikh-Salah, Moktar; Peppercorn, Jeffrey

2013-07-20

Little is known about the effects of financial relationships between biomedical researchers and industry (financial conflicts of interest [FCOIs]) on research prominence. We examined the prevalence of FCOIs in oncology and associations between FCOIs and research prominence among abstracts presented at American Society of Clinical Oncology (ASCO) annual meetings. We analyzed 20,718 abstracts presented at ASCO meetings in 2006 and 2008 to 2011. Measures included the following: financial relationships, peer review score (PRS), and meeting placement prominence (descending order of prominence: plenary session, clinical science symposium, oral presentation, poster discussion, general posters, and publish only). Of 20,718 abstracts, 36% reported at least one author with an FCOI. The proportion of abstracts with any FCOI increased from 33% in 2006 to 38% in 2011 (P < .001). Abstracts with FCOIs had significantly higher meeting prominence compared with publish only and general poster abstracts. The odds ratios compared with general posters were 7.3 for plenary session, 2.2 for clinical science symposium, 1.9 for oral presentation, and 1.7 for poster discussion (P < .001). Abstracts with FCOIs had significantly better PRSs compared with those without FCOIs. For all abstracts, PRS was 2.76 (95% CI, 2.75 to 2.77) with FCOIs compared with 3.01 (95% CI, 3.001 to 3.02) without FCOIs (P < .001). Omitting publish-only abstracts, PRS was 2.62 (95% CI, 2.61 to 2.63) with FCOIs compared with 2.73 without FCOIs (95% CI, 2.71 to 2.73). Abstracts with FCOIs had more prominent meeting placement and better PRSs. FCOIs were reported more frequently by year, suggesting an increasing influence of industry on cancer research, greater disclosure, or both.

Guidelines for human epidermal growth factor receptor 2 testing: biologic and methodologic considerations.

PubMed

Sauter, Guido; Lee, James; Bartlett, John M S; Slamon, Dennis J; Press, Michael F

2009-03-10

The goal of this review is to systematically address a number of issues raised in the American Society of Clinical Oncology-College of American Pathologists (ASCO-CAP) guidelines on testing for the human epidermal growth factor receptor 2 (HER-2) alteration. A group of investigators who are experienced in the conduct and interpretation of HER-2 assay methods reviewed the ASCO-CAP guidelines and address several areas of the HER-2 testing guidelines with a particular emphasis on biologic and methodologic considerations. Although HER-2 status determined by immunohistochemistry (IHC) and the status determined by fluorescent in situ hybridization (FISH) are significantly correlated, we feel that standard considerations of laboratory testing, including test accuracy, reproducibility, and precision, as well as the current data favor FISH over IHC assay methods for determining HER-2 status. These considerations are clearly important in clinical practice because HER2 amplification is directly linked to protein expression levels in breast cancer. However, this protein is not consistently analyzed in formalin-fixed tissues as a result of variability in fixation methods and times and the impact of fixation on HER-2 protein antigenicity. Conversely, gene amplification and FISH are significantly less dependent on tissue fixation methods, making this assay more reproducible between central and peripheral laboratories than IHC. Moreover, review of the existing data demonstrate that FISH is more strongly correlated with responsiveness to either trastuzumab or lapatinib treatment. Until other methods achieve similar test accuracy, reproducibility, and predictive value, we suggest FISH as the primary HER-2 testing modality for women with breast cancer who are candidates for HER-2-targeted therapies.

Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer

PubMed Central

Wolff, Antonio C.; Hammond, M. Elizabeth H.; Hicks, David G.; Dowsett, Mitch; McShane, Lisa M.; Allison, Kimberly H.; Allred, Donald C.; Bartlett, John M.S.; Bilous, Michael; Fitzgibbons, Patrick; Hanna, Wedad; Jenkins, Robert B.; Mangu, Pamela B.; Paik, Soonmyung; Perez, Edith A.; Press, Michael F.; Spears, Patricia A.; Vance, Gail H.; Viale, Giuseppe; Hayes, Daniel F.

2014-01-01

Purpose To update the American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guideline recommendations for human epidermal growth factor receptor 2 (HER2) testing in breast cancer to improve the accuracy of HER2 testing and its utility as a predictive marker in invasive breast cancer. Methods ASCO/CAP convened an Update Committee that included coauthors of the 2007 guideline to conduct a systematic literature review and update recommendations for optimal HER2 testing. Results The Update Committee identified criteria and areas requiring clarification to improve the accuracy of HER2 testing by immunohistochemistry (IHC) or in situ hybridization (ISH). The guideline was reviewed and approved by both organizations. Recommendations The Update Committee recommends that HER2 status (HER2 negative or positive) be determined in all patients with invasive (early stage or recurrence) breast cancer on the basis of one or more HER2 test results (negative, equivocal, or positive). Testing criteria define HER2-positive status when (on observing within an area of tumor that amounts to >10% of contiguous and homogeneous tumor cells) there is evidence of protein overexpression (IHC) or gene amplification (HER2 copy number or HER2/CEP17 ratio by ISH based on counting at least 20 cells within the area). If results are equivocal (revised criteria), reflex testing should be performed using an alternative assay (IHC or ISH). Repeat testing should be considered if results seem discordant with other histopathologic findings. Laboratories should demonstrate high concordance with a validated HER2 test on a sufficiently large and representative set of specimens. Testing must be performed in a laboratory accredited by CAP or another accrediting entity. The Update Committee urges providers and health systems to cooperate to ensure the highest quality testing. PMID:24099077

Highlights from the 37th Annual Meeting of the American Society of Clinical Oncology, San Francisco, USA, 12–15 May 2001

PubMed Central

Lohrisch, Caroline

2001-01-01

Key issues discussed at the breast cancer sessions of the 37th American Society of Clinical Oncology (ASCO) meeting, 2001, included the following: breast cancer in the elderly; toxicity; updates on HER2 and use of trastuzumab (anti-HER2) in metastatic disease; and several early reports on novel therapeutic strategies. As was stated by numerous speakers both at this and other meetings, and as demonstrated by several abstracts, the use of predictive factors appears to be the most effective way to enhance the efficacy of numerous therapies, both target specific and nonspecific.

Value Frameworks in Oncology: Comparative Analysis and Implications to the Pharmaceutical Industry.

PubMed

Slomiany, Mark; Madhavan, Priya; Kuehn, Michael; Richardson, Sasha

2017-07-01

As the cost of oncology care continues to rise, composite value models that variably capture the diverse concerns of patients, physicians, payers, policymakers, and the pharmaceutical industry have begun to take shape. To review the capabilities and limitations of 5 of the most notable value frameworks in oncology that have emerged in recent years and to compare their relative value and application among the intended stakeholders. We compared the methodology of the American Society of Clinical Oncology (ASCO) Value Framework (version 2.0), the National Comprehensive Cancer Network Evidence Blocks, Memorial Sloan Kettering Cancer Center DrugAbacus, the Institute for Clinical and Economic Review Value Assessment Framework, and the European Society for Medical Oncology Magnitude of Clinical Benefit Scale, using a side-by-side comparative approach in terms of the input, scoring methodology, and output of each framework. In addition, we gleaned stakeholder insights about these frameworks and their potential real-world applications through dialogues with physicians and payers, as well as through secondary research and an aggregate analysis of previously published survey results. The analysis identified several framework-specific themes in their respective focus on clinical trial elements, breadth of evidence, evidence weighting, scoring methodology, and value to stakeholders. Our dialogues with physicians and our aggregate analysis of previous surveys revealed a varying level of awareness of, and use of, each of the value frameworks in clinical practice. For example, although the ASCO Value Framework appears nascent in clinical practice, physicians believe that the frameworks will be more useful in practice in the future as they become more established and as their outputs are more widely accepted. Along with patients and payers, who bear the burden of treatment costs, physicians and policymakers have waded into the discussion of defining value in oncology care, as well as pharmaceutical companies that seek to understand the impact of these value frameworks on each stakeholder, as they model the value and financial threshold of innovative, high-cost drugs.

Cancer log-kill revisited.

PubMed

Norton, Larry

2014-01-01

At the root of science lie basic rules, if we can discover or deduce them. This is not an abstract project but practical; if we can understand the why then perhaps we can rationally intervene. One of the unifying unsolved problems in physics is the hypothetical "Theory of Everything." In a similar vein, we can ask whether our own field contains such hidden fundamental truths and, if so, how we can use them to develop better therapies and outcomes for our patients. Modern oncology has developed as drugs and translational science have matured over the 50 years since ASCO's founding, but almost from that beginning tumor modeling has been a key tool. Through this general approach Norton and Simon changed our understanding of cancer biology and response to therapy when they described the fit of Gompertzian curves to both clinical and animal observations of tumor growth. The practical relevance of these insights has only grown with the development of DNA sequencing promising a raft of new targets (and drugs). In that regard, Larry Norton's contribution to this year's Educational Book reminds us to always think creatively about the fundamental problems of tumor growth and metastases as well as therapeutic response. Demonstrating the creativity and thoughtfulness that have marked his remarkable career, he now incorporates a newer concept of self-seeding to further explain why Gompertzian growth occurs and, in the process, provides a novel potential therapeutic target. As you read his elegantly presented discussion, consider how this understanding, wisely applied to the modern era of targeted therapies, might speed the availability of better treatments. But even more instructive is his personal model-not only the Norton-Simon Hypothesis-of how to live and approach science, biology, patients and their families, as well as the broader community. He shows that with energy, enthusiasm, optimism, intellect, and hard work we can make the world better. Clifford A. Hudis, MD, FACP, 2013-2014 ASCO President.

Barriers to a Career Focus in Cancer Prevention: A Report and Initial Recommendations From the American Society of Clinical Oncology Cancer Prevention Workforce Pipeline Work Group

PubMed Central

Meyskens, Frank L.; Bajorin, Dean F.; George, Thomas J.; Jeter, Joanne M.; Khan, Shakila; Tyne, Courtney A.; William, William N.

2016-01-01

Purpose To assist in determining barriers to an oncology career incorporating cancer prevention, the American Society of Clinical Oncology (ASCO) Cancer Prevention Workforce Pipeline Work Group sponsored surveys of training program directors and oncology fellows. Methods Separate surveys with parallel questions were administered to training program directors at their fall 2013 retreat and to oncology fellows as part of their February 2014 in-training examination survey. Forty-seven (67%) of 70 training directors and 1,306 (80%) of 1,634 oncology fellows taking the in-training examination survey answered questions. Results Training directors estimated that ≤ 10% of fellows starting an academic career or entering private practice would have a career focus in cancer prevention. Only 15% of fellows indicated they would likely be interested in cancer prevention as a career focus, although only 12% thought prevention was unimportant relative to treatment. Top fellow-listed barriers to an academic career were difficulty in obtaining funding and lower compensation. Additional barriers to an academic career with a prevention focus included unclear career model, lack of clinical mentors, lack of clinical training opportunities, and concerns about reimbursement. Conclusion Reluctance to incorporate cancer prevention into an oncology career seems to stem from lack of mentors and exposure during training, unclear career path, and uncertainty regarding reimbursement. Suggested approaches to begin to remedy this problem include: 1) more ASCO-led and other prevention educational resources for fellows, training directors, and practicing oncologists; 2) an increase in funded training and clinical research opportunities, including reintroduction of the R25T award; 3) an increase in the prevention content of accrediting examinations for clinical oncologists; and 4) interaction with policymakers to broaden the scope and depth of reimbursement for prevention counseling and intervention services. PMID:26527778

Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline.

PubMed

Brahmer, Julie R; Lacchetti, Christina; Schneider, Bryan J; Atkins, Michael B; Brassil, Kelly J; Caterino, Jeffrey M; Chau, Ian; Ernstoff, Marc S; Gardner, Jennifer M; Ginex, Pamela; Hallmeyer, Sigrun; Holter Chakrabarty, Jennifer; Leighl, Natasha B; Mammen, Jennifer S; McDermott, David F; Naing, Aung; Nastoupil, Loretta J; Phillips, Tanyanika; Porter, Laura D; Puzanov, Igor; Reichner, Cristina A; Santomasso, Bianca D; Seigel, Carole; Spira, Alexander; Suarez-Almazor, Maria E; Wang, Yinghong; Weber, Jeffrey S; Wolchok, Jedd D; Thompson, John A

2018-06-10

Purpose To increase awareness, outline strategies, and offer guidance on the recommended management of immune-related adverse events in patients treated with immune checkpoint inhibitor (ICPi) therapy. Methods A multidisciplinary, multi-organizational panel of experts in medical oncology, dermatology, gastroenterology, rheumatology, pulmonology, endocrinology, urology, neurology, hematology, emergency medicine, nursing, trialist, and advocacy was convened to develop the clinical practice guideline. Guideline development involved a systematic review of the literature and an informal consensus process. The systematic review focused on guidelines, systematic reviews and meta-analyses, randomized controlled trials, and case series published from 2000 through 2017. Results The systematic review identified 204 eligible publications. Much of the evidence consisted of systematic reviews of observational data, consensus guidelines, case series, and case reports. Due to the paucity of high-quality evidence on management of immune-related adverse events, recommendations are based on expert consensus. Recommendations Recommendations for specific organ system-based toxicity diagnosis and management are presented. While management varies according to organ system affected, in general, ICPi therapy should be continued with close monitoring for grade 1 toxicities, with the exception of some neurologic, hematologic, and cardiac toxicities. ICPi therapy may be suspended for most grade 2 toxicities, with consideration of resuming when symptoms revert to grade 1 or less. Corticosteroids may be administered. Grade 3 toxicities generally warrant suspension of ICPis and the initiation of high-dose corticosteroids (prednisone 1 to 2 mg/kg/d or methylprednisolone 1 to 2 mg/kg/d). Corticosteroids should be tapered over the course of at least 4 to 6 weeks. Some refractory cases may require infliximab or other immunosuppressive therapy. In general, permanent discontinuation of ICPis is recommended with grade 4 toxicities, with the exception of endocrinopathies that have been controlled by hormone replacement. Additional information is available at www.asco.org/supportive-care-guidelines and www.asco.org/guidelineswiki .

Chemotherapy and targeted therapy in advanced biliary tract carcinoma: a pooled analysis of clinical trials.

PubMed

Eckel, Florian; Schmid, Roland M

2014-01-01

In biliary tract cancer, gemcitabine platinum (GP) doublet palliative chemotherapy is the current standard treatment. The aim of this study was to analyze recent trials, even those small and nonrandomized, and identify superior new regimens. Trials published in English between January 2000 and January 2014 were analyzed, as well as ASCO abstracts from 2010 to 2013. In total, 161 trials comprising 6,337 patients were analyzed. The pooled results of standard therapy GP (no fluoropyrimidine, F, or other drug) were as follows: the median response rate (RR), tumor control rate (TCR), time to tumor progression (TTP) and overall survival (OS) were 25.9 and 63.5%, and 5.3 and 9.5 months, respectively. GFP triplets as well as G-based chemotherapy plus targeted therapy were significantly superior to GP concerning tumor control (TCR, TTP) and OS, with no difference in RR. Triplet combinations of GFP as well as G-based chemotherapy with (predominantly EGFR) targeted therapy are most effective concerning tumor control and survival.

[Anticancer drugs: Which prices for therapeutic innovations?].

PubMed

Gonçalves, Anthony; Maraninchi, Dominique; Marino, Patricia

2016-04-01

The expanding knowledge of the biological mechanisms underlying tumor development made it possible the recent emergence of new therapeutic approaches that are considered as undoubtedly innovative. Yet, to define and to evaluate the magnitude of a drug innovation require an examination of its intrinsic drug properties, medical utility as well as its mode of emergence. Recently, international academic societies, such as ESMO and ASCO, have proposed practical tools that may help quantifying the medical value of a given innovation. Currently, the sustained flux of therapeutic innovations in oncology is associated with an unprecedented growth of costs, the actual determinants of which remain under debate, but raising the critical issue of drugs pricing, and their potential individual or societal "financial toxicity". Copyright © 2016. Published by Elsevier Masson SAS.

ABP 980: promising trastuzumab biosimilar for HER2-positive breast cancer.

PubMed

Paplomata, Elisavet; Nahta, Rita

2018-03-01

Approval of the HER2-targeted antibody trastuzumab dramatically improved outcomes for patients with HER2-positive breast cancer. Multiple trastuzumab biosimilars, including ABP 980, are in clinical development. Biosimilars are not identical to the reference biologic, but exhibit equivalence and safety in analytical and clinical studies. Areas covered: A brief introduction to trastuzumab, overview of trastuzumab biosimilars, and detailed review of ABP 980 preclinical and clinical studies are included. We searched PubMed and 2016-2017 ASCO and ESMO conference proceedings for 'ABP 980' or 'trastuzumab biosimilar'. 'ABP 980 and breast cancer' or 'trastuzumab biosimilar and breast cancer' were used to search clinicaltrials.gov for phase III trials. Analytical studies of ABP 980 pharmacokinetics (PK) or pharmacodynamics (PD), phase I studies of ABP 980 safety and PK/PD, and phase III studies of clinical efficacy vs trastuzumab are included. Expert opinion: Questions remain regarding long-term impact of biosimilars on overall healthcare costs, insurance coverage of multiple approved biosimilars, and extensive clinical safety and efficacy follow-up. By producing a competitive market, trastuzumab biosimilars are anticipated to improve access to standard of care therapies, although real-world evidence remains to be obtained. Increased global access to HER2-targeted therapy may eventually alter the landscape of breast cancer and survival rates.

Systemic Therapy for Stage IV Non–Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update

PubMed Central

Masters, Gregory A.; Temin, Sarah; Azzoli, Christopher G.; Giaccone, Giuseppe; Baker, Sherman; Brahmer, Julie R.; Ellis, Peter M.; Gajra, Ajeet; Rackear, Nancy; Schiller, Joan H.; Smith, Thomas J.; Strawn, John R.; Trent, David; Johnson, David H.

2015-01-01

Purpose To provide evidence-based recommendations to update the American Society of Clinical Oncology guideline on systemic therapy for stage IV non–small-cell lung cancer (NSCLC). Methods An Update Committee of the American Society of Clinical Oncology NSCLC Expert Panel based recommendations on a systematic review of randomized controlled trials from January 2007 to February 2014. Results This guideline update reflects changes in evidence since the previous guideline. Recommendations There is no cure for patients with stage IV NSCLC. For patients with performance status (PS) 0 to 1 (and appropriate patient cases with PS 2) and without an EGFR-sensitizing mutation or ALK gene rearrangement, combination cytotoxic chemotherapy is recommended, guided by histology, with early concurrent palliative care. Recommendations for patients in the first-line setting include platinum-doublet therapy for those with PS 0 to 1 (bevacizumab may be added to carboplatin plus paclitaxel if no contraindications); combination or single-agent chemotherapy or palliative care alone for those with PS 2; afatinib, erlotinib, or gefitinib for those with sensitizing EGFR mutations; crizotinib for those with ALK or ROS1 gene rearrangement; and following first-line recommendations or using platinum plus etoposide for those with large-cell neuroendocrine carcinoma. Maintenance therapy includes pemetrexed continuation for patients with stable disease or response to first-line pemetrexed-containing regimens, alternative chemotherapy, or a chemotherapy break. In the second-line setting, recommendations include docetaxel, erlotinib, gefitinib, or pemetrexed for patients with nonsquamous cell carcinoma; docetaxel, erlotinib, or gefitinib for those with squamous cell carcinoma; and chemotherapy or ceritinib for those with ALK rearrangement who experience progression after crizotinib. In the third-line setting, for patients who have not received erlotinib or gefitinib, treatment with erlotinib is recommended. There are insufficient data to recommend routine third-line cytotoxic therapy. Decisions regarding systemic therapy should not be made based on age alone. Additional information can be found at http://www.asco.org/guidelines/nsclc and http://www.asco.org/guidelineswiki. PMID:26324367

Clinical benefit, price and approval characteristics of FDA-approved new drugs for treating advanced solid cancer, 2000-2015.

PubMed

Vivot, A; Jacot, J; Zeitoun, J-D; Ravaud, P; Crequit, P; Porcher, R

2017-05-01

Prices of anti-cancer drugs are skyrocking. We aimed to assess the clinical benefit of new drugs for treating advanced solid tumors at the time of their approval by the US Food and Drug Administration (FDA) and to search for a relation between price and clinical benefit of drugs. We included all new molecular entities and new biologics for treating advanced solid cancer that were approved by the FDA between 2000 and 2015. The clinical benefit of drugs was graded based on FDA medical review of pivotal clinical trials using the 2016-updated of the American Society of Clinical Oncology Value Framework (ASCO-VF) and the European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS). Characteristics of drugs and approvals were obtained from publicly available FDA documents and price was evaluated according to US Medicare, US Veterans Health Administration and United Kingdom market systems. The FDA approved 51 new drugs for advanced solid cancer from 2000 to 2015; we could evaluate the value of 37 drugs (73%). By the ESMO-MCBS, five drugs (14%) were grade one (the lowest), nine (24%) grade two, 10 (27%) grade three, 11 (30%) grade four and two (5%) grade five (the highest). Thus, 13 drugs (35%) showed a meaningful clinical benefit (scale levels 4 and 5). By the ASCO-VF which had a range of 3.4-67, the median drug value was 37 (interquartile range 20-52). We found no relationship between clinical benefit and drug price (P = 0.9). No characteristic of drugs and of approval was significantly associated with clinical benefit. Many recently FDA-approved new cancer drugs did not have high clinical benefit as measured by current scales. We found no relation between the price of drugs and benefit to society and patients. © The Author 2017. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Cloud condensation nuclei closure study on summer arctic aerosol

NASA Astrophysics Data System (ADS)

Martin, M.; Chang, R. Y.-W.; Sierau, B.; Sjogren, S.; Swietlicki, E.; Abbatt, J. P. D.; Leck, C.; Lohmann, U.

2011-11-01

We present an aerosol - cloud condensation nuclei (CCN) closure study on summer high Arctic aerosol based on measurements that were carried out in 2008 during the Arctic Summer Cloud Ocean Study (ASCOS) on board the Swedish ice breaker Oden. The data presented here were collected during a three-week time period in the pack ice (>85° N) when the icebreaker Oden was moored to an ice floe and drifted passively during the most biological active period into autumn freeze up conditions. CCN number concentrations were obtained using two CCN counters measuring at different supersaturations. The directly measured CCN number concentration was then compared with a CCN number concentration calculated using both bulk aerosol mass composition data from an aerosol mass spectrometer (AMS) and aerosol number size distributions obtained from a differential mobility particle sizer, assuming κ-Köhler theory, surface tension of water and an internally mixed aerosol. The last assumption was supported by measurements made with a hygroscopic tandem differential mobility analyzer (HTDMA) for particles >70 nm. For the two highest measured supersaturations, 0.73 and 0.41%, closure could not be achieved with the investigated settings concerning hygroscopicity and density. The calculated CCN number concentration was always higher than the measured one for those two supersaturations. This might be caused by a relative larger insoluble organic mass fraction of the smaller particles that activate at these supersaturations, which are thus less good CCN than the larger particles. On average, 36% of the mass measured with the AMS was organic mass. At 0.20, 0.15 and 0.10% supersaturation, closure could be achieved with different combinations of hygroscopic parameters and densities within the uncertainty range of the fit. The best agreement of the calculated CCN number concentration with the observed one was achieved when the organic fraction of the aerosol was treated as nearly water insoluble (κorg=0.02), leading to a mean total κ, κtot, of 0.33 ± 0.13. However, several settings led to closure and κorg=0.2 is found to be an upper limit at 0.1% supersaturation. κorg≤0.2 leads to a κtot range of 0.33 ± 013 to 0.50 ± 0.11. Thus, the organic material ranges from being sparingly soluble to effectively insoluble. These results suggest that an increase in organic mass fraction in particles of a certain size would lead to a suppression of the Arctic CCN activity.

Perspectives on the Use of Clinical Pathways in Oncology Care.

PubMed

Chiang, Anne C; Ellis, Peter; Zon, Robin

2017-01-01

Pathways and guidelines are valuable tools to provide evidence-based care in oncology. Pathways may be more restrictive than guidelines because they attempt (where possible) to reduce cost, add efficiency, and remove unwarranted variability. Pathways offer an opportunity to measure, report, and improve quality of care; they can drive to evidence-based targeted therapy where appropriate; they can enhance efficiency through standardization; and, finally, they can be a vehicle to enhance participation in clinical trials. Pathway implementation requires understanding and commitment on the part of the physician and leadership as they may initially disrupt workflow, but ultimately have the ability to enhance patient care. ASCO criteria have been published for the development and implementation of high-quality oncology pathway programs. Future challenges for pathways include incorporation of molecular testing and appropriate targeted care in a real-time precision oncology approach.

Why the Quality Oncology Practice Initiative Matters: It's Not Just About Cost.

PubMed

Chiang, Anne C

2016-01-01

The nature and cost of cancer care is evolving, affecting more patients and often involving expensive treatment options. The upward cost trends also coincide with a national landscape of increasing regulatory mandates that may demand improved outcomes and value, but that often require significant up-front investment in infrastructure to achieve safety and quality. Oncology practices participating in the American Society of Clinical Oncology (ASCO) Institute for Quality's Quality Oncology Practice Initiative (QOPI) and the QOPI Certification Program (QCP) continue to grow in number and reflect changing demographics of the provision of cancer care. QOPI and QCP benchmarking can be used to achieve quality improvement and to build collaborative quality communities. These programs may be useful tools for oncology practices to comply with new legislation such as the Medicare Access and CHIP Reauthorization Act (MACRA).

DOE Office of Scientific and Technical Information (OSTI.GOV)

De Blas, Alfredo; Tapia, Carlos; Riego, Albert

pGamma is a code developed by the NERG group of the Technical University of Catalonia - Barcelona Tech for the analysis of gamma spectra generated by the Equipment for the Continuous Measurement and Identification of Gamma Radioactivity on Aerosols with Paper Filter developed for our group and Raditel Servies company. Nowadays the code is in the process of adaptation for the monitors of the Environmental Radiological Surveillance Network of the Local Government of Catalonia (Generalitat of Catalonia), Spain. The code is a Spectrum Analysis System, it identifies the gamma emitters on the spectrum, determines its Concentration of Activity, generates alarmsmore » depending on the Activity of the emitters and generates a report. The Spectrum Analysis System includes a library with emitters of interest, NORM and artificial. The code is being used on the three stations with the aerosol monitor of the Network (Asco and Vandellos, near both Nuclear Power Plants and Barcelona). (authors)« less

American Society of Clinical Oncology Position Statement: Strategies for Reducing Cancer Health Disparities Among Sexual and Gender Minority Populations.

PubMed

Griggs, Jennifer; Maingi, Shail; Blinder, Victoria; Denduluri, Neelima; Khorana, Alok A; Norton, Larry; Francisco, Michael; Wollins, Dana S; Rowland, Julia H

2017-07-01

ASCO is committed to addressing the needs of sexual and gender minority (SGM) populations as a diverse group at risk for receiving disparate care and having suboptimal experiences, including discrimination, throughout the cancer care continuum. This position statement outlines five areas of recommendations to address the needs of both SGM populations affected by cancer and members of the oncology workforce who identify as SGM: (1) patient education and support; (2) workforce development and diversity; (3) quality improvement strategies; (4) policy solutions; and (5) research strategies. In making these recommendations, the Society calls for increased outreach and educational support for SGM patients; increased SGM cultural competency training for providers; improvement of quality-of-care metrics that include sexual orientation and gender information variables; and increased data collection to inform future work addressing the needs of SGM communities.

Real-World Conundrums and Biases in the Use of White Cell Growth Factors.

PubMed

Smith, Thomas J; Hillner, Bruce E

2016-01-01

We present the 2015 American Society of Clinical Oncology (ASCO) white cell growth factors, or colony-stimulating factor (CSF), guidelines, updated from 2006. One new indication has been added-dose-intense chemotherapy for bladder cancer-to accompany the existing use for dose-dense breast cancer chemotherapy. Colony-stimulating factors remain appropriate for any regimen where the risk of febrile neutropenia is about 20% per cycle and dose reduction is not appropriate. Based on new evidence from multiple trials, CSF use is no longer indicated in treatment of lymphoma unless there are special risk factors. The United States accounts for 78% of the sales of CSF. The panel approved the use of all biosimilars, but the cost savings will be small as the price is about 80% of the branded CSFs. More biosimilars at lower cost are awaited. Methods to reduce use without harm to patients, by requiring justification according to accepted guidelines, are ongoing.

Molecular assays in detecting EGFR gene aberrations: an updated HER2-dependent algorithm for interpreting gene signals; a short technical report.

PubMed

Tsiambas, Evangelos; Ragos, Vasileios; Lefas, Alicia Y; Georgiannos, Stavros N; Rigopoulos, Dimitrios N; Georgakopoulos, Georgios; Stamatelopoulos, Athanasios; Grapsa, Dimitra; Syrigos, Konstantinos

2016-01-01

Purpose: Among oncogenes that have already been identified and cloned, Epidermal Growth Factor Receptor (EGFR) remains one of the most significant. Understanding its deregulation mechanisms improves critically patients' selection for personalized therapies based on modern molecular biology and oncology guidelines. Anti-EGFR targeted therapeutic strategies have been developed based on specific genetic profiles and applied in subgroups of patients suffering by solid cancers of different histogenetic origin. Detection of specific EGFR somatic mutations leads to tyrosine kinase inhibitors (TKIs) application in subsets of them. Concerning EGFR gene numerical imbalances, identification of pure gene amplification is critical for targeting the molecule via monoclonal antibodies (mAbs). In the current technical paper we demonstrate the main molecular methods applied in EGFR analyses focused also on new data in interpreting numerical imbalances based on ASCO/ACAP guidelines for HER2 in situ hybridization (ISH) clarifications.

Assessing the Eventual Publication of Clinical Trial Abstracts Submitted to a Large Annual Oncology Meeting

PubMed Central

Wang, Ruibin; Prasad, Vinay; Bates, Susan E.; Fojo, Tito

2016-01-01

Background. Despite the ethical imperative to publish clinical trials when human subjects are involved, such data frequently remain unpublished. The objectives were to tabulate the rate and ascertain factors associated with eventual publication of clinical trial results reported as abstracts in the Proceedings of the American Society of Clinical Oncology (American Society of Clinical Oncology). Materials and Methods. Abstracts describing clinical trials for patients with breast, lung, colorectal, ovarian, and prostate cancer from 2009 to 2011 were identified by using a comprehensive online database (http://meetinglibrary.asco.org/abstracts). Abstracts included reported results of a treatment or intervention assessed in a discrete, prospective clinical trial. Publication status at 4−6 years was determined by using a standardized search of PubMed. Primary outcomes were the rate of publication for abstracts of randomized and nonrandomized clinical trials. Secondary outcomes included factors influencing the publication of results. Results. A total of 1,075 abstracts describing 378 randomized and 697 nonrandomized clinical trials were evaluated. Across all years, 75% of randomized and 54% of nonrandomized trials were published, with an overall publication rate of 61%. Sample size was a statistically significant predictor of publication for both randomized and nonrandomized trials (odds ratio [OR] per increase of 100 participants = 1.23 [1.11–1.36], p < .001; and 1.64 [1.15–2.34], p = .006, respectively). Among randomized studies, an industry coauthor or involvement of a cooperative group increased the likelihood of publication (OR 2.37, p = .013; and 2.21, p = .01, respectively). Among nonrandomized studies, phase II trials were more likely to be published than phase I (p < .001). Use of an experimental agent was not a predictor of publication in randomized (OR 0.76 [0.38–1.52]; p = .441) or nonrandomized trials (OR 0.89 [0.61–1.29]; p = .532). Conclusion. This is the largest reported study examining why oncology trials are not published. The data show that 4−6 years after appearing as abstracts, 39% of oncology clinical trials remain unpublished. Larger sample size and advanced trial phase were associated with eventual publication; among randomized trials, an industry-affiliated author or a cooperative group increased likelihood of publication. Unfortunately, we found that, despite widespread recognition of the problem and the creation of central data repositories, timely publishing of oncology clinical trials results remains unsatisfactory. Implications for Practice: The Declaration of Helsinki Ethical Principles for Medical Research Involving Human Subjects notes the ethical obligation to report clinical trial data, whether positive or negative. This obligation is listed alongside requirements for risk minimization, access, confidentiality, and informed consent, all bedrocks of the clinical trial system, yet clinical trials are often not published, particularly if negative or difficult to complete. This study found that among American Society for Clinical Oncology (ASCO) Annual Meeting abstracts, 2009–2011, only 61% were published 4–6 years later: 75% of randomized trials and 54% of nonrandomized trials. Clinicians need to insist that every study in which they participate is published. PMID:26888691

Enzalutamide for the treatment of prostate cancer

PubMed Central

Pal, Sumanta K.; Stein, Cy A.; Sartor, Oliver

2013-01-01

Introduction The FDA approval of docetaxel for metastatic castration-resistant prostate cancer (mCRPC) in 2005 marked a major milestone – as it was the first approved agent for this disease that demonstrated a survival advantage in phase III assessment in this disease. Since 2009, several other agents have been FDA approved, including sipuleucel-T, abiraterone, cabazitaxel and enzalutamide. Enzalutamide, a potent antiandrogen that blocks nuclear translocation of the androgen receptor (AR) is the most recently approved of these agents. Areas Covered The clinical development of enzalutamide is discussed, with attention given as to how this agent will most appropriately be used among a growing list of agents for mCRPC. A MEDLINE search was conducted to identify all relevant published datasets pertaining to the drug. In addition, relevant ASCO and ESMO abstracts were searched. Expert Opinion The current role and sequencing of enzalutamide may change drastically based on studies such as PREVAIL (a phase III pre-chemotherapy assessment of enzalutamide) and planned studies to assess relevant combinations (i.e., enzalutamide with abiraterone). Outside of clinical efficacy, issues such as drug cost may ultimately dictate our utilization of agents such as enzalutamide for mCPRC. Although the development of biomarkers to guide therapy for mCRPC is ideal, there are inherent challenges in establishing biomarker-driven treatment. PMID:23441761

The NCI Community Oncology Research Program: what every clinician needs to know.

PubMed

McCaskill-Stevens, Worta; Lyss, Alan P; Good, Marge; Marsland, Thomas; Lilenbaum, Rogerio

2013-01-01

Research in the community setting is essential for the translation of advances in cancer research into practice and improving cancer care for all populations. The National Cancer Institute is proposing a new community-based program, NCI Community Oncology Research Program (NCORP), which is the alignment of two existing programs, the Community Clinical Oncology Program, Minority-Based Community Clinical Oncology Program, and their Research Bases, and the National Cancer Institute's Community Cancer Centers Program. NCROP will support cancer control, prevention, treatment, and screening clinical trials and expand its research scope to include cancer care delivery research. Cancer disparities research will be integrated into studies across the continuum of NCORP research. Input from current NCI-funded community investigators provides critical insight into the challenges faced by oncology practices within various organizational structures. Furthermore, these investigators identify the resources, both administrative and clinical, that will be required in the community setting to support cancer care delivery research and to meet the requirements for a new generation of clinical research. The American Society for Clinical Oncology (ASCO) has initiated a forum to focus on the conduct of clinical research in the community setting. Resources are being developed to help practices in managing cancer care in community settings.

Future Supply and Demand for Oncologists : Challenges to Assuring Access to Oncology Services

PubMed Central

Erikson, Clese; Salsberg, Edward; Forte, Gaetano; Bruinooge, Suanna; Goldstein, Michael

2007-01-01

Purpose To conduct a comprehensive analysis of supply of and demand for oncology services through 2020. This study was commissioned by the Board of Directors of ASCO. Methods New data on physician supply gathered from surveys of practicing oncologists, oncology fellows, and fellowship program directors were analyzed, along with 2005 American Medical Association Masterfile data on practicing medical oncologists, hematologists/oncologists, and gynecologic oncologists, to determine the baseline capacity and to forecast visit capacity through 2020. Demand for visits was calculated by applying age-, sex-, and time-from-diagnosis-visit rate data from the National Cancer Institute's analysis of the 1998 to 2002 Surveillance, Epidemiology and End Results (SEER) database to the National Cancer Institute's cancer incidence and prevalence projections. The cancer incidence and prevalence projections were calculated by applying a 3-year average (2000–2002) of age- and sex-specific cancer rates from SEER to the US Census Bureau population projections released on March 2004. The baseline supply and demand forecasts assume no change in cancer care delivery and physician practice patterns. Alternate scenarios were constructed by changing assumptions in the baseline models. Results Demand for oncology services is expected to rise rapidly, driven by the aging and growth of the population and improvements in cancer survival rates, at the same time the oncology workforce is aging and retiring in increasing numbers. Demand is expected to rise 48% between 2005 and 2020. The supply of services provided by oncologists during this time is expected to grow more slowly, approximately 14%, based on the current age distribution and practice patterns of oncologists and the number of oncology fellowship positions. This translates into a shortage of 9.4 to 15.0 million visits, or 2,550 to 4,080 oncologists—roughly one-quarter to one-third of the 2005 supply. The baseline projections do not include any alterations based on changes in practice patterns, service use, or cancer treatments. Various alternate scenarios were also developed to show how supply and demand might change under different assumptions. Conclusions ASCO, policy makers, and the public have major challenges ahead of them to forestall likely shortages in the capacity to meet future demand for oncology services. A multifaceted strategy will be needed to ensure that Americans have access to oncology services in 2020, as no single action will fill the likely gap between supply and demand. Among the options to consider are increasing the number of oncology fellowship positions, increasing use of nonphysician clinicians, increasing the role of primary care physicians in the care of patients in remission, and redesigning service delivery. PMID:20859376

Incidence and relative risk of peripheral neuropathy in cancer patients treated with eribulin: a meta-analysis.

PubMed

Peng, Ling; Hong, Yun; Ye, Xianghua; Shi, Peng; Zhang, Junyan; Wang, Yina; Zhao, Qiong

2017-12-19

Eribulin is a microtubule inhibitor, which is approved for the treatment of breast cancer. Peripheral neuropathy has been reported in the studies of eribulin, but the incidence and relative risk (RR) of eribulin-associated peripheral neuropathy varied greatly in cancer patients. The purpose of this meta-analysis was to determine the overall incidence and RR of eribulin-associated peripheral neuropathy in cancer patients. Pubmed database and Embase and abstracts presented at the American Society of Clinical Oncology (ASCO) meetings were systematically reviewed for primary studies. Eligible studies included prospective clinical trials and expanded access programs of cancer patients treated with eribulin. Statistical analyses were performed to calculate the incidences, RRs, and 95% confidence intervals (CIs). Altogether, 4,849 patients from 19 clinical trials were selected for this meta-analysis. The incidences of all-grade and high-grade peripheral neuropathy were 27.5% (95% CI: 23.3-32.4%) and 4.7% (95% CI: 3.6-6.2%), respectively. The relative risks of peripheral neuropathy of eribulin compared to control were increased for all-grade (RR = 1.89, 95% CI: 1.10-3.25) but not statistically significant for high-grade (RR = 2.98, 95% CI: 0.71-12.42). The use of eribulin is associated with an increased incidence of peripheral neuropathy. The RR is increased for all-grade peripheral neuropathy.

Ocean heat budget analysis on sea surface temperature anomaly in western Indian Ocean during strong-weak Asian summer monsoon

NASA Astrophysics Data System (ADS)

Fathrio, Ibnu; Manda, Atsuyoshi; Iizuka, Satoshi; Kodama, Yasu-Masa; Ishida, Sachinobu

2018-05-01

This study presents ocean heat budget analysis on seas surface temperature (SST) anomalies during strong-weak Asian summer monsoon (southwest monsoon). As discussed by previous studies, there was close relationship between variations of Asian summer monsoon and SST anomaly in western Indian Ocean. In this study we utilized ocean heat budget analysis to elucidate the dominant mechanism that is responsible for generating SST anomaly during weak-strong boreal summer monsoon. Our results showed ocean advection plays more important role to initate SST anomaly than the atmospheric prcess (surface heat flux). Scatterplot analysis showed that vertical advection initiated SST anomaly in western Arabian Sea and southwestern Indian Ocean, while zonal advection initiated SST anomaly in western equatorial Indian Ocean.

Spaceborne Studies Of Ocean Circulation

NASA Astrophysics Data System (ADS)

Patzert, William C.

1984-08-01

The global view of the oceans seen by Seasat during its 1978 flight demonstrated the feasibility of ocean remote sensing. These first-ever global data sets of sea surface topography (altimeter) and marine winds (scatterometer) laid the foundation for two satellite missions planned for the late 1980's. The future missions are the next generation of altimeter and scatterometer to be flown aboard TOPEX (Topography Experiment) and NROSS (Navy Remote Ocean Sensing System), respectively. The data from these satellites will be coordinated with measurements made at sea to determine the driving forces of ocean circulation and to study the oceans role in climate variability. Sea surface winds (calculated from scatterometer measurements) are the fundamental driving force for ocean waves and currents (estimated from altimeter measurements). On a global scale, the winds and currents are approximately equal partners in redistributing the excess heat gained in the tropics from solar radiation to the cooler polar regions. Small perturbations in this system can dramatically alter global weather, such as the El Niho event of 1982-83. During an El Ni?io event, global wind patterns and ocean currents are perturbed causing unusual ocean warming in the tropical Pacfic Ocean. These ocean events are coupled to complex fluctuations in global weather. Only with satellites will we be able to collect the global data sets needed to study events such as El Ni?o. When TOPEX and NROSS fly, oceanographers will have the equivalent of meteorological high and low pressure charts of ocean topography as well as the surface winds to study ocean "weather." This ability to measure ocean circulation and its driving forces is a critical element in understanding the influence of oceans on society. Climatic changes, fisheries, commerce, waste disposal, and national defense are all involved.

Major clinical research advances in gynecologic cancer in 2014.

PubMed

Suh, Dong Hoon; Lee, Kyung Hun; Kim, Kidong; Kang, Sokbom; Kim, Jae Weon

2015-04-01

In 2014, 9 topics were selected as major advances in clinical research for gynecologic oncology: 2 each in cervical and corpus cancer, 4 in ovarian cancer, and 1 in breast cancer. For cervical cancer, several therapeutic agents showed viable antitumor clinical response in recurrent and metastatic disease: bevacizumab, cediranib, and immunotherapies including human papillomavirus (HPV)-tumor infiltrating lymphocytes and Z-100. The HPV test received FDA approval as the primary screening tool of cervical cancer in women aged 25 and older, based on the results of the ATHENA trial, which suggested that the HPV test was a more sensitive and efficient strategy for cervical cancer screening than methods based solely on cytology. For corpus cancers, results of a phase III Gynecologic Oncology Group (GOG) 249 study of early-stage endometrial cancer with high-intermediate risk factors are followed by the controversial topic of uterine power morcellation in minimally invasive gynecologic surgery. Promising results of phase II studies regarding the effectiveness of olaparib in various ovarian cancer settings are summarized. After a brief review of results from a phase III study on pazopanib maintenance therapy in advanced ovarian cancer, 2 outstanding 2014 ASCO presentations cover the topic of using molecular subtypes in predicting response to bevacizumab. A review of the use of opportunistic bilateral salpingectomy as an ovarian cancer preventive strategy in the general population is presented. Two remarkable studies that discussed the effectiveness of adjuvant ovarian suppression in premenopausal early breast cancer have been selected as the last topics covered in this review.

DOE Office of Scientific and Technical Information (OSTI.GOV)

De Blas, Alfredo; Tapia, Carlos; Riego, Albert

Presentation the Equipment for the Continuous Measurement and Identification of Gamma Radioactivity on Aerosols developed by the Nuclear Engineering Research Group (NERG) from the Technical University of Catalonia (UPC) and the Raditel Company. The device is based on a fixed filter of glass fiber (100% borosilicate), this allows determine the concentration of activity of gamma emitters on aerosols in air. A specifically developed Spectrometry Analysis System has been developed. The analysis of the spectra allows the identification of the emitters and determine the concentration of activity. Nowadays four Stations with this equipment are operating on the Environmental Radiological Surveillance Networkmore » of the Catalonian Generalitat (Spain): two near the Asco and Vandellos Nuclear Power Plants in the province of Tarragona and one in the city of Barcelona. Soon a fourth monitor will be incorporated at Roses (province of Girona) and a fifth in Puigcerda (province of Barcelona). We present measurements and analysis of the evolution of the emitters identified on different stations of the Network. (authors)« less

[Multidisciplinary oncopalliative meeting: Aims and pratical recommendations].

PubMed

Goldwasser, François; Nisenbaum, Nathalie; Vinant, Pascale; Balladur, Elisabeth; Dauchy, Sarah; Farota-Romejko, Idriss; Colombet, Isabelle; Alby, Marie-Laure; Giroux, Julie; Larrouy, Anne; Destaintot, Elisabeth; Garcon, Luc; Legrand, Danièle; Marin, Isabelle

2018-05-01

Progress leads to increase life duration at the metastatic stage but metastatic disease is most often lethal. Decision-making is necessary for an increasing period of care, beyond evidence-based medicine, dealing with complexity and uncertain benefit/risk ratio. This requires to inform the patient realistically, to discuss prognostication, to develop anticipated written preferences. These changes mean to pass from a medicine based on informed consent to medicine based on respect of the patient wishes even if it can be complex to determine. A new multidisciplinarity is needed, centered on the meaning of the care, the proportionality of the care, the anticipated patient trajectory. The ASCO has published recommendations on early palliative care. The timing and the quality of the discussion between palliative care specialists and oncologists is crucial. We propose 10 steps to organize a multidisciplinary onco-palliative meeting, as it appears the key for the organization of care in non-curable disease. Copyright © 2018 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

Current treatment options for recurrent/metastatic head and neck cancer: a post-ASCO 2011 update and review of last year's literature.

PubMed

Kurzweg, T; Möckelmann, N; Laban, S; Knecht, R

2012-10-01

The majority of patients with a squamous cell carcinoma of the head and neck present with locally advanced tumors. The first-line treatment of locally advanced tumor stages consists of a combined modality management. Despite these aggressive protocols, many patients develop locoregional recurrences or metastasis and place particularly high demands on the interdisciplinary treatment team. Treatment with a curative intent must be differentiated from a palliative one. In addition to prior treatment, resectability, age and performance status, patient wishes must be taken into consideration in treatment planning, especially considering that most therapies offer little to no overall survival benefit. Salvage surgery, chemo- and target therapies, and reirradiation are head and neck surgeon's and radiooncologist's weapons in the fight against these strong opponents. This review focuses on publications and meeting news from last year and reviews the current status of the clinical application of each treatment modality in recurrent or metastatic head and neck cancer.

[Recent advances in patient-related outcome in gynaecological cancer].

PubMed

Brachet, Pierre Emmanuel; Joly, Florence

2014-01-01

The evaluation of quality of life has become essential in gynecological oncology. Recent guidelines have been published to improve the collection, analysis and publication of the data quality of life that will make them more reliable, reproducible and integrate them into the final treatment decision. This year at ASCO, in breast cancer, the benefit of sentinel lymph node dissection compared to the quality of life has been demonstrated. New data on cognitive function in patients treated for breast cancer show the importance of the evaluation of these disorders especially among elderly patients who are at-risk populations. Medical strategies including targeted therapies can improve survival without impairing the quality of life, also with improved gastrointestinal symptoms in case of combination chemotherapy with bevacizumab in patients with ovarian cancer in a situation early recurrence. Similarly, the addition of a pathway inhibitor M- Tor (everolimus) with hormonal therapy does not induce degradation of the quality of life in women with metastatic breast cancer.

The Impacts of Daily Surface Forcing in the Upper Ocean over Tropical Pacific: A Numerical Study

NASA Technical Reports Server (NTRS)

Sui, C.-H.; Rienecker, Michele M.; Li, Xiaofan; Lau, William K.-M.; Laszlo, Istvan; Pinker, Rachel T.

2001-01-01

Tropical Pacific Ocean is an important region that affects global climate. How the ocean responds to the atmospheric surface forcing (surface radiative, heat and momentum fluxes) is a major topic in oceanographic research community. The ocean becomes warm when more heat flux puts into the ocean. The monthly mean forcing has been used in the past years since daily forcing was unavailable due to the lack of observations. The daily forcing is now available from the satellite measurements. This study investigates the response of the upper ocean over tropical Pacific to the daily atmospheric surface forcing. The ocean surface heat budgets are calculated to determine the important processes for the oceanic response. The differences of oceanic responses between the eastern and western Pacific are intensively discussed.

ENRICH: A promising oncology nurse training program to implement ASCO clinical practice guidelines on fertility for AYA cancer patients.

PubMed

Vadaparampil, Susan T; Gwede, Clement K; Meade, Cathy; Kelvin, Joanne; Reich, Richard R; Reinecke, Joyce; Bowman, Meghan; Sehovic, Ivana; Quinn, Gwendolyn P

2016-11-01

We describe the impact of ENRICH (Educating Nurses about Reproductive Issues in Cancer Healthcare), a web-based communication-skill-building curriculum for oncology nurses regarding AYA fertility and other reproductive health issues. Participants completed an 8-week course that incorporated didactic content, case studies, and interactive learning. Each learner completed a pre- and post-test assessing knowledge and a 6-month follow-up survey assessing learner behaviors and institutional changes. Out of 77 participants, the majority (72%) scored higher on the post-test. Fifty-four participants completed the follow-up survey: 41% reviewed current institutional practices, 20% formed a committee, and 37% gathered patient materials or financial resources (22%). Participants also reported new policies (30%), in-service education (37%), new patient education materials (26%), a patient navigator role (28%), and workplace collaborations with reproductive specialists (46%). ENRICH improved nurses' knowledge and involvement in activities addressing fertility needs of oncology patients. Our study provides a readily accessible model to prepare oncology nurses to integrate American Society of Clinical Oncology guidelines and improve Quality Oncology Practice Initiative measures related to fertility. Nurses will be better prepared to discuss important survivorship issues related to fertility and reproductive health, leading to improved quality of life outcomes for AYAs. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

[Cytokines in cancer chemotherapy: present state and problems in use of G- and GM-CSF for solid tumors in Japan].

PubMed

Ogawara, M

1998-01-01

The present state and the problems of G and GM-CSF in cancer chemotherapy, especially for solid tumors in Japan, were reviewed. One of the problems is that adaptation is restricted to several tumors, and the other that recommended doses are about half or one-fourth as much as in North America or Europe. With G-CSF after dose-intensive chemotherapy in small-cell lung cancer, three studies showed G-CSF shortened the duration of neutropenia, and reduced the incidence of neutropenic fever, use of antibiotics and hospitalization, while they showed no advantages in terms of response rate and the incidence of infection-related death. Moreover, the effect on survival has not been proved. In afebrile neutropenic patients, G-CSF could accelerate recovery from neutropenia, but did not reduce the incidence of neutropenic fever. In febrile neutropenic patients with antibiotics, it could also accelerate recovery from neutropenia, but did not reduce neutropenic fever compared with no CSF except in some subsets. Our retrospective study showed the effects of G-CSF in grade 4 neutropenia were comparable with grade 3 neutropenia. The functions of neutrophils with G-CSF after chemotherapy were reported to be increased or maintained. Clinical benefits were only obtained in certain dose-intensive chemotherapy or in limited subsets. Additional clinical trials and a guideline like ASCO's should be planned.

Is heterostyly rare on oceanic islands?

PubMed Central

Watanabe, Kenta; Sugawara, Takashi

2015-01-01

Heterostyly has been considered rare or absent on oceanic islands. However, there has been no comprehensive review on this issue. Is heterostyly truly rare on oceanic islands? What makes heterostyly rare on such islands? To answer these questions, we review the reproductive studies on heterostyly on oceanic islands, with special emphasis on the heterostylous genus Psychotria in the Pacific Ocean as a model system. Overall, not many reproductive studies have been performed on heterostylous species on oceanic islands. In Hawaiian Psychotria, all 11 species are thought to have evolved dioecy from distyly. In the West Pacific, three species on the oceanic Bonin and Lanyu Islands are distylous (Psychotria homalosperma, P. boninensis and P. cephalophora), whereas three species on the continental Ryukyu Islands show various breeding systems, such as distyly (P. serpens), dioecy (P. rubra) and monoecy (P. manillensis). On some other Pacific oceanic islands, possibilities of monomorphy have been reported. For many Psychotria species, breeding systems are unknown, although recent studies indicate that heterostylous species may occur on some oceanic islands. A shift from heterostyly to other sexual systems may occur on some oceanic islands. This tendency may also contribute to the rarity of heterostyly, in addition to the difficulty in colonization/autochthonous evolution of heterostylous species on oceanic islands. Further investigation of reproductive systems of Psychotria on oceanic islands using robust phylogenetic frameworks would provide new insights into plant reproduction on oceanic islands. PMID:26199401

Measuring Ocean Literacy: What teens understand about the ocean using the Survey of Ocean Literacy and Engagement (SOLE)

NASA Astrophysics Data System (ADS)

Greely, T. M.; Lodge, A.

2009-12-01

Ocean issues with conceptual ties to science and global society have captured the attention, imagination, and concern of an international audience. Climate change, over fishing, marine pollution, freshwater shortages and alternative energy sources are a few ocean issues highlighted in our media and casual conversations. The ocean plays a role in our life in some way everyday, however, disconnect exists between what scientists know and the public understands about the ocean as revealed by numerous ocean and coastal literacy surveys. While the public exhibits emotive responses through care, concern and connection with the ocean, there remains a critical need for a baseline of ocean knowledge. However, knowledge about the ocean must be balanced with understanding about how to apply ocean information to daily decisions and actions. The present study analyzed underlying factors and patterns contributing to ocean literacy and reasoning within the context of an ocean education program, the Oceanography Camp for Girls. The OCG is designed to advance ocean conceptual understanding and decision making by engagement in a series of experiential learning and stewardship activities from authentic research settings in the field and lab. The present study measured a) what understanding teens currently hold about the ocean (content), b) how teens feel toward the ocean environment (environmental attitudes and morality), and c) how understanding and feelings are organized when reasoning about ocean socioscientific issues (e.g. climate change, over fishing, energy). The Survey of Ocean Literacy and Engagement (SOLE), was used to measure teens understanding about the ocean. SOLE is a 57-item survey instrument aligned with the Essential Principles and Fundamental Concepts of Ocean Literacy (NGS, 2007). Rasch analysis was used to refine and validate SOLE as a reasonable measure of ocean content knowledge (reliability, 0.91). Results revealed that content knowledge and environmental attitudes significantly contributed to ocean literacy. Teens demonstrated a 2-32% increase in content knowledge following the OCG learning experience. The most significant content gains correlated with ocean literacy Essential Principles 1, 2 and 5. Analysis of environmental reasoning patterns revealed that biocentric reasoning (71%) was most important to teens in solving ocean dilemmas. Further, teens reasoning about challenging ocean dilemmas were capable of supporting a position, counter-argument, rebuttal, and accurately use scientific information. Findings provide empirical evidence that connects field studies with ocean literacy. Current guidelines for ocean literacy address cognitive understanding but lack multimodality. The need for ocean literacy that goes beyond content to include reasoning and actions is relevant towards preparing students, teachers and citizens to regularly contribute to decisions about ocean issues and undertake actions as consumer, citizen or steward. This research supports the use of socioscientific issues and stewardship to advance ‘functional’ ocean literacy.

Ocean Opportunities. A Guide to What the Oceans Have to Offer.

ERIC Educational Resources Information Center

Burtis, William S.

High school students interested in ocean-related careers will find their imagination piqued by "Ocean Opportunities." As the ocean's resources are recognized more and more as extremely important economically, yet very fragile, study of those resources is burgeoning. This multi-color booklet describes the exciting opportunities which ocean research…

The predictive role of skin rash with cetuximab and panitumumab in colorectal cancer patients: a systematic review and meta-analysis of published trials.

PubMed

Petrelli, F; Borgonovo, K; Barni, S

2013-09-01

Skin rash is an early and frequent phenomenon during treatment with anti-epidermal growth factor receptor monoclonal antibodies. The objective of this review is to assess the predictive value of skin rash in patients with advanced colorectal cancer treated with cetuximab and panitumumab. We searched PubMed and ASCO Meetings for publications reporting the correlation of skin rash with survival and/or response rate. Hazard ratios (HRs) with 95% confidence intervals for progression and/or survival, and/or risk ratios (RRs) for response rate in patients with rash were obtained from publications and pooled in a meta-analysis. Fourteen publications (for a total of 3,833 patients) were included in this meta-analysis. The occurrence of skin toxicity represents a predictive factor for survival (HR 0.51; p<0.00001) and progression (HR 0.58; p<0.00001). Similarly, patients who developed moderate or severe rash had an increased chance of response (35 vs 13%; RR 2.23, p<0.00001). The occurrence of skin rash during treatment with cetuximab and panitumumab represents a significant predictor of the efficacy of these drugs. The hypothesis that, in patients who lack substantial skin toxicity, this treatment is not beneficial and requires early discontinuation deserves further study.

The Edges of the Ocean: An Introduction.

ERIC Educational Resources Information Center

Burke, Kevin

1979-01-01

Introduces a series of related articles on the study of ocean/continent boundaries (margins) within the framework of plate tectonics. Topics discussed include: early attempts to interpret ocean/continent boundaries, Atlantic-type margins, Pacific-type margins, the edges of ancient oceans, and future challenges in the study of continental margins.…

The Importance of Economic Perspective and Quantitative Approaches in Oncology Value Frameworks of Drug Selection and Shared Decision Making.

PubMed

Waldeck, A Reginald; Botteman, Marc F; White, Richard E; van Hout, Ben A

2017-06-01

The debate around value in oncology drug selection has been prominent in recent years, and several professional bodies have furthered this debate by advocating for so-called value frameworks. Herein, we provide a viewpoint on these value frameworks, emphasizing the need to consider 4 key aspects: (1) the economic underpinnings of value; (2) the importance of the perspective adopted in the valuation; (3) the importance of the difference between absolute and relative measures of risk and measuring patient preferences; and (4) the recognition of multiple quality-of-life (QoL) domains, and the aggregation and valuation of those domains, through utilities within a multicriteria decision analysis, may allow prioritization of QoL above the tallying of safety events, particularly in a value framework focusing on the individual patient. While several frameworks exist, they incorporate different attributes and-importantly-assess value from alternative perspectives, including those of patients, regulators, payers, and society. The various perspectives necessarily lead to potentially different, if not sometimes divergent, conclusions about the valuation. We show that the perspective of the valuation affects the framing of the risk/benefit question and the methodology to measure the individual patient choice, or preference, as opposed to the collective, or population, choice. We focus specifically on the American Society of Clinical Oncology (ASCO) Value Framework. We argue that its laudable intent to assist in shared clinician-patient decision making can be augmented by more formally adopting methodology underpinned by micro- and health economic concepts, as well as application of formal quantitative approaches. Our recommendations for value frameworks focusing on the individual patient, such as the ASCO Value Framework, are 3-fold: (1) ensure that stakeholders understand the importance of the adopted (economic) perspective; (2) consider using exclusively absolute measures of risk and formal patient-preference methodology; and (3) consider foregoing safety parameters for higher-order utility considerations. No funding was received for conceptualizing, writing, and/or editing this manuscript. Waldeck and White are employees of, and received stock option grants from, Celldex Therapeutics. Van Hout and Botteman are employees and shareholders of Pharmerit International. Pharmerit International is a research contractor for Celldex. All authors have retained editorial control of the content of the manuscript. Conceptualization of this viewpoint article was contributed primarily by Waldeck, along with Botteman, White, and van Hout. Data analysis and revision of the manuscript was contributed equally by all the authors. The manuscript was written by Waldeck, Botteman, van Hout, and White.

Importance of ocean salinity for climate and habitability

PubMed Central

Cullum, Jodie; Stevens, David P.; Joshi, Manoj M.

2016-01-01

Modeling studies of terrestrial extrasolar planetary climates are now including the effects of ocean circulation due to a recognition of the importance of oceans for climate; indeed, the peak equator-pole ocean heat transport on Earth peaks at almost half that of the atmosphere. However, such studies have made the assumption that fundamental oceanic properties, such as salinity, temperature, and depth, are similar to Earth. This assumption results in Earth-like circulations: a meridional overturning with warm water moving poleward at the surface, being cooled, sinking at high latitudes, and traveling equatorward at depth. Here it is shown that an exoplanetary ocean with a different salinity can circulate in the opposite direction: an equatorward flow of polar water at the surface, sinking in the tropics, and filling the deep ocean with warm water. This alternative flow regime results in a dramatic warming in the polar regions, demonstrated here using both a conceptual model and an ocean general circulation model. These results highlight the importance of ocean salinity for exoplanetary climate and consequent habitability and the need for its consideration in future studies. PMID:27044090

Importance of ocean salinity for climate and habitability.

PubMed

Cullum, Jodie; Stevens, David P; Joshi, Manoj M

2016-04-19

Modeling studies of terrestrial extrasolar planetary climates are now including the effects of ocean circulation due to a recognition of the importance of oceans for climate; indeed, the peak equator-pole ocean heat transport on Earth peaks at almost half that of the atmosphere. However, such studies have made the assumption that fundamental oceanic properties, such as salinity, temperature, and depth, are similar to Earth. This assumption results in Earth-like circulations: a meridional overturning with warm water moving poleward at the surface, being cooled, sinking at high latitudes, and traveling equatorward at depth. Here it is shown that an exoplanetary ocean with a different salinity can circulate in the opposite direction: an equatorward flow of polar water at the surface, sinking in the tropics, and filling the deep ocean with warm water. This alternative flow regime results in a dramatic warming in the polar regions, demonstrated here using both a conceptual model and an ocean general circulation model. These results highlight the importance of ocean salinity for exoplanetary climate and consequent habitability and the need for its consideration in future studies.

Incidence and relative risk of peripheral neuropathy in cancer patients treated with eribulin: a meta-analysis

PubMed Central

Peng, Ling; Hong, Yun; Ye, Xianghua; Shi, Peng; Zhang, Junyan; Wang, Yina; Zhao, Qiong

2017-01-01

Background Eribulin is a microtubule inhibitor, which is approved for the treatment of breast cancer. Peripheral neuropathy has been reported in the studies of eribulin, but the incidence and relative risk (RR) of eribulin-associated peripheral neuropathy varied greatly in cancer patients. The purpose of this meta-analysis was to determine the overall incidence and RR of eribulin-associated peripheral neuropathy in cancer patients. Materials and Methods Pubmed database and Embase and abstracts presented at the American Society of Clinical Oncology (ASCO) meetings were systematically reviewed for primary studies. Eligible studies included prospective clinical trials and expanded access programs of cancer patients treated with eribulin. Statistical analyses were performed to calculate the incidences, RRs, and 95% confidence intervals (CIs). Results Altogether, 4,849 patients from 19 clinical trials were selected for this meta-analysis. The incidences of all-grade and high-grade peripheral neuropathy were 27.5% (95% CI: 23.3–32.4%) and 4.7% (95% CI: 3.6–6.2%), respectively. The relative risks of peripheral neuropathy of eribulin compared to control were increased for all-grade (RR = 1.89, 95% CI: 1.10–3.25) but not statistically significant for high-grade (RR = 2.98, 95% CI: 0.71–12.42). Conclusions The use of eribulin is associated with an increased incidence of peripheral neuropathy. The RR is increased for all-grade peripheral neuropathy. PMID:29340112

Surveillance and monitoring in breast cancer survivors: maximizing benefit and minimizing harm.

PubMed

Jochelson, Maxine; Hayes, Daniel F; Ganz, Patricia A

2013-01-01

Although the incidence of breast cancer has increased, breast cancer mortality has decreased, likely as a result of both breast cancer screening and improved treatment. There are well over two million breast cancer survivors in the United States for whom appropriate surveillance continues to be a subject of controversy. The guidelines from the American Society of Clinical Oncology (ASCO) and the American College of Physicians are clear: only performance of yearly screening mammography is supported by evidence. Although advanced imaging technologies and sophisticated circulating tumor biomarker studies are exquisitely sensitive for the detection of recurrent breast cancer, there is no proof that earlier detection of metastases will improve outcome. A lack of specificity may lead to more tests and patient anxiety. Many breast cancer survivors are not followed by oncologists, and their doctors may not be familiar with these recommendations. Oncologists also disregard the data. A plethora of both blood tests and nonmammographic imaging tests are frequently performed in asymptomatic women. The blood tests, marker studies, and advanced imaging techniques are expensive and, with limited health care funds, may prevent funding for more appropriate aspects of patient care. Abnormal marker studies lead to additional imaging procedures. Repeated CT scans and radionuclide imaging may induce a second cancer because of the radiation dose, and invasive procedures performed as a result of these examinations also add risk to patients without clear benefits. Improved adherence to the current guidelines can cut costs, reduce risks, and improve patient quality of life without adversely affecting outcome.

Prospective multi-center study for quantification of chemotherapies and CTX-related direct medication costs avoided by use of biomarkers uPA and PAI-1 in primary breast cancer.

PubMed

Jacobs, Volker R; Augustin, Doris; Wischnik, Arthur; Kiechle, Marion; Höss, Cornelia; Steinkohl, Oliver; Rack, Brigitte; Kapitza, Thomas; Krase, Peter

2013-08-01

Biomarkers uPA/PAI-1 as recommended by ASCO and AGO are used in primary breast cancer to avoid unnecessary CTX in medium risk-recurrence patients. This study verified how many CTX cycles and CTX-related direct medication costs can be avoided by uPA/PAI-1 testing. A prospective, non-interventional, multi-center study was performed among six Certified Breast Centers to analyze application of uPA/PAI-1 and consecutive decision-making. CTX avoided were identified and direct costs for CTX, CTX-related concomitant medication and febrile neutropenia (FN) prophylaxis with G-CSF calculated. In n = 93 breast cancers n = 35 CTX (37.6%) with 210 CTX cycles were avoided according to uPA/PAI-1 test result. uPA/PAI-1 testing saved direct medication costs for CTX of 177,453 €, CTX-related concomitant medication of 27,482 € and FN prophylaxis of 20,599 €, overall 225,534 €. At test costs at 287.50 € uPA/PAI-1 testing resulted in additional costs of 26,737.50 €. uPA/PAI-1 has proven to be cost-effective at a return-on-investment ratio of 8.4:1. Indirect cost savings further increase this ROI. These results support decision-making for cost-effective diagnostics and therapy in breast cancer. Copyright © 2013 Elsevier Ltd. All rights reserved.

The Need for a Southern Branch Campus of Ocean County College.

ERIC Educational Resources Information Center

Ocean County Coll., Toms River, NJ. Office of Institutional Research.

In 1989, a study was conducted at Ocean County College (OCC) to determine the feasibility of establishing a branch campus in southern Ocean County, New Jersey. Specific factors examined in the study included Ocean County's demographic characteristics (e.g., land area and dispersion, population trends, public transportation, and economic trends);…

Light fields in the ocean

NASA Technical Reports Server (NTRS)

Pelevin, V. N.; Kozlyaninov, M. V.

1981-01-01

The problem of light fields in the ocean is in basic ocean optics. Twenty-six separate studies discuss: (1) the field of solar radiation in the ocean; (2) stationary and nonstationary light fields created in the sea by artificial sources; and (3) the use of optical methods to study biological and hydrodynamic characteristics of the sea.

Method and application of ocean environmental awareness measurement: Lessons learnt from university students of China.

PubMed

Umuhire, Marie Louise; Fang, Qinhua

2016-01-30

Different studies have proved that enhancing public Ocean Environmental Awareness (OEA) will lead to increased public support for ocean environmental protection. Our study develops a questionnaire to investigate current levels of students' OEA from three aspects including ocean environmental concerns, ocean environment knowledge and willingness to participate in ocean related activities. This questionnaire was applied to students from Xiamen University to understand the OEA of university students in China, of which there are few studies. Using data gathered from a random purposive sample, the OEA level of students in Xiamen University was investigated and then the influencing factors (education, geographical situation, age and gender etc.) were further analyzed. Findings suggest that most students are concerned about the ocean environment but their knowledge is not enough that makes the willingness to participate in ocean related actions limited as well. The results show there is an urgent need to improve students' OEA. Copyright © 2015 Elsevier Ltd. All rights reserved.

NSF final project report planning and implementation of the U.S. Joint Global Ocean Flux Study (U.S. JGOFS)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Livingston, Hugh D.

1996-07-01

Conducted planning and implementation of ocean carbon dioxide hydrographic surveys ocean process studies, time-series studies of Bermuda and Hawaii, and sponsored scientific workshops for those activities.

The dynamic tidal response of a subsurface ocean on Titan and the associated dissipative heat generated

NASA Astrophysics Data System (ADS)

Tyler, Robert

2012-04-01

The tidal flow response and associated dissipative heat generated in a satellite ocean depends strongly on the ocean configuration parameters as these parameters control the form and frequencies of the ocean's natural modes of oscillation; if there is a near match between the form and frequency of one of these natural modes and that of one of the available tidal forcing constituents, the ocean can be resonantly excited, producing strong tidal flow and appreciable dissipative heat. Of primary interest in this study are the ocean parameters that can be expected to evolve (notably, the ocean depth in an ocean attempting to freeze, and the stratification in an ocean attempting to cool) because this evolution can cause an ocean to be pushed into a resonant configuration where the increased dissipative heat of the resonant response halts further evolution and a liquid ocean can be maintained by ocean tidal heat. In this case the resonant ocean tidal response is not only allowed but may be inevitable. Previous work on this topic is extended to describe the resonant configurations in both unstratified and stratified cases for an assumed global ocean on Titan subject to both obliquity and eccentricity tidal forces. Results indicate first that the assumption of an equilibrium tidal response is not justified and the correct dynamical response must be considered. Second, the ocean tidal dissipation will be appreciable if the ocean configuration is near that producing a resonant state. The parameters values required for this resonance are provided in this study, and examples/movies of calculated ocean tidal flow are also presented.

Priorities in Ocean Science Study

ERIC Educational Resources Information Center

Awkerman, Gary L.; And Others

1974-01-01

Reports on a national survey conducted to determine priorities in ocean science study as identified by oceanographers. The priority determinations gave equal weight to relevance and academic importance of ocean problems. (Author/GS)

The association of BMI and outcomes in metastatic melanoma: A retrospective, multicohort analysis of patients treated with targeted therapy, immunotherapy, or chemotherapy

PubMed Central

McQuade, Jennifer L.; Daniel, Carrie R.; Hess, Kenneth R.; Mak, Carmen; Wang, Daniel Y.; Rai, Rajat R.; Park, John J.; Haydu, Lauren E.; Spencer, Christine; Wongchenko, Matthew; Lane, Stephen; Lee, Dung-Yang; Kaper, Mathilde; McKean, Meredith; Beckermann, Kathryn E; Rubinstein, Samuel M.; Rooney, Isabelle; Musib, Luna; Budha, Nageshwar; Hsu, Jessie; Nowicki, Theodore S.; Avila, Alexandre; Haas, Tomas; Puligandla, Maneka; Lee, Sandra; Fang, Shenying; Wargo, Jennifer A.; Gershenwald, Jeffrey E; Lee, Jeffrey E.; Hwu, Patrick; Chapman, Paul B.; Sosman, Jeffrey A.; Schadendorf, Dirk; Grob, Jean-Jacques; Flaherty, Keith T.; Walker, Dana; Yan, Yibing; McKenna, Edward; Legos, Jeffrey J.; Carlino, Matteo S.; Ribas, Antoni; Kirkwood, John M.; Long, Georgina V.; Johnson, Douglas B.; Menzies, Alexander M; Davies, Michael A.

2018-01-01

Background Obesity has been linked to increased mortality in several cancer types; however, the relationship between obesity and survival in metastatic melanoma is unknown. The aim of this study was to examine the association between BMI, progression-free survival (PFS), and overall survival (OS) in metastatic melanoma. Methods This study included 6 independent cohorts for a total of 1918 metastatic melanoma patients. These included two targeted therapy cohorts [randomized control trials (RCTs) of dabrafenib and trametinib (n=599) and vemurafenib and cobimetinib (n=240)], two immunotherapy cohorts [RCT of ipilimumab + dacarbazine (DTIC) (n=207) and a retrospective cohort treated with anti-PD-1/PDL-1 (n=331)], and two chemotherapy cohorts [RCT DTIC cohorts (n=320 and n=221)]. BMI was classified as normal (BMI 18 to <25; n=694 of 1918, 36.1%) overweight (BMI 25-29.9; n=711, 37.1%) or obese (BMI≥30; n=513, 26.7%). The primary outcomes were the association between BMI, PFS, and OS, stratified by treatment type and sex. These exploratory analyses were based on previously reported intention-to-treat data from the RCTs. The effect of BMI on PFS and OS was assessed by multivariable-adjusted Cox models in independent cohorts. In order to provide a more precise estimate of the association between BMI and outcomes, as well as the interaction between BMI, sex, and therapy type, adjusted hazard ratios were combined in mixed-effects meta-analyses and heterogeneity was explored with meta-regression analyses. Findings In the pooled analysis, obesity, as compared to normal BMI, was associated with improved survival in patients with metastatic melanoma [average adjusted hazard ratio (HR) and 95% CI: 0.77 (0.66-0.90) and 0.74 (0.58-0.95) for PFS and OS, respectively]. The survival benefit associated with obesity was restricted to patients treated with targeted therapy [0.72 (0.57-0.91) and 0.60 (0.45-0.79) for PFS and OS, respectively] and immunotherapy [0.75 (0.56-1.00) and 0.64 (0.47-0.86)]. No associations were observed with chemotherapy [0.87 (0.65-1.17) and 1.03 (0.80-1.34); treatment p for interaction = 0.61 and 0.01, for PFS and OS, respectively]. The prognostic effect of BMI with targeted and immune therapies differed by sex with pronounced inverse associations in males [PFS 0.67 (0.53-0.84) and OS 0.53 (0.40-0.70)], but not females [PFS 0.92 (0.70-1.23) and OS 0.85 (0.61-1.18), sex p for interaction= 0.08 and 0.03, for PFS and OS, respectively] Interpretation Obesity is associated with improved PFS and OS in metastatic melanoma, driven by strong associations observed in males treated with targeted or immune therapy. The magnitude of the benefit detected supports the need for investigation into the underlying mechanism of these unexpected observations Funding ASCO/CCF Young Investigator Award and ASCO/CCF Career Development Award to JLM PMID:29449192

A study on atmospheric and oceanic processes in the north Indian Ocean

NASA Astrophysics Data System (ADS)

Felton, Clifford S.

Studies on oceanic and atmospheric processes in the Indian Ocean are an active and important area of scientific research. Understanding how intraseasonal and interannual variations impact both the ocean and atmosphere will aid in delineating potential feedback mechanisms and global teleconnections. Thanks to recent efforts focused on expanding observational capabilities and developing models for this region, researchers have been able to begin investigating atmospheric and oceanic processes in the Indian Ocean. This study focuses on the impact of the El Nino Southern Oscillation (ENSO) on tropical cyclone activity over the Bay of Bengal (BoB) and on developing a method for estimating the barrier layer thickness (BLT) in the Indian Ocean from satellite observations. National Center for Environmental Prediction (NCEP-2) and Simple Ocean Data Assimilation (SODA) reanalysis data are used to investigate the alterations in atmospheric and oceanic conditions that impact tropical cyclones during ENSO events over a 33-year time frame (1979-2011). Atmospheric conditions are shown to be more favorable for tropical cyclone development during La Nina over the BoB due to the favorable alteration of large-scale wind, moisture, and vorticity distributions. By combining multiple satellite observations, including the recently launched Soil Moisture and Ocean Salinity (SMOS) and Aquarius SAC-D salinity missions, BLT estimates for the Indian Ocean are generated with the use of a multilinear regression model (MRM). The performance of the MRM is evaluated for the Southeast Arabian Sea (SEAS), Bay of Bengal (BoB), and Eastern Equatorial Indian Ocean (EEIO) where barrier layer formation is most rigorous. Results from the MRM suggest that salinity measurements obtained from Aquarius and SMOS can be useful for tracking and predicting the BLT in the Indian Ocean.

NASA Oceanic Processes Program, fiscal year 1983

NASA Technical Reports Server (NTRS)

Nelson, R. M. (Editor); Pieri, D. C. (Editor)

1984-01-01

Accomplishments, activities, and plans are highlighted for studies of ocean circulation, air sea interaction, ocean productivity, and sea ice. Flight projects discussed include TOPEX, the ocean color imager, the advanced RF tracking system, the NASA scatterometer, and the pilot ocean data system. Over 200 papers generated by the program are listed.

Anomalous intraseasonal events in the thermocline ridge region of Southern Tropical Indian Ocean and their regional impacts

NASA Astrophysics Data System (ADS)

Jayakumar, A.; Gnanaseelan, C.

2012-03-01

The present study explores the mechanisms responsible for the strong intraseasonal cooling events in the Thermocline Ridge region of the southwestern Indian Ocean. Air sea interface and oceanic processes associated with Madden Julian Oscillation are studied using an Ocean General Circulation Model and satellite observations. Sensitivity experiments are designed to understand the ocean response to intraseasonal forcing with a special emphasis on 2002 cooling events, which recorded the strongest intraseasonal perturbations during the last well-observed decade. This event is characterized by anomalous Walker circulation over the tropical Indian Ocean and persistent intraseasonal heat flux anomaly for a longer duration than is typical for similar events (but without any favorable preconditioning of ocean basic state at the interannual timescale). The model heat budget analysis during 1996 to 2007 revealed an in-phase relationship between atmospheric fluxes associated with Madden Julian Oscillation and the subsurface oceanic processes during the intense cooling events of 2002. The strong convection, reduced shortwave radiation and increased evaporation have contributed to the upper ocean heat loss in addition to the slower propagation of active phase of convection, which supported the integration of longer duration of forcing. The sensitivity experiments revealed that dynamic response of ocean through entrainment at the intraseasonal timescale primarily controls the biological response during the event, with oceanic interannual variability playing a secondary role. This study further speculates the role of oceanic intraseasonal variability in the 2002 droughts over Indian subcontinent.

PubMed Central

Lux, Michael P.; Janni, Wolfgang; Hartkopf, Andreas D.; Nabieva, Naiba; Taran, Florin-Andrei; Overkamp, Friedrich; Kolberg, Hans-Christian; Hadji, Peyman; Tesch, Hans; Ettl, Johannes; Huober, Jens B.; Lüftner, Diana; Wallwiener, Markus; Müller, Volkmar; Beckmann, Matthias W.; Belleville, Erik; Fehm, Tanja N.; Wallwiener, Diethelm; Brucker, Sara Y.; Schneeweiss, Andreas; Fasching, Peter A.

2017-01-01

In recent years, numerous new therapy options for patients with breast cancer have been developed in clinical studies, with some options already approved for routine treatment. As the speed at which innovations are introduced increases, the importance of conferences also increases, as conferences are where the data underpinning new therapies are usually presented for the first time. This review looks at publications of the ASCO (American Society of Clinical Oncology) and ESMO (European Society of Medical Oncology) conferences in 2017, summarizes them and evaluates them in the context of existing data. The focus is on new insights for neoadjuvant therapy and new treatment options in the metastatic setting, such as the use of CDK4/6 inhibitors or PARP inhibitors. The first results of treatments with checkpoint inhibitors are presented. With the patent expiry of trastuzumab, a number of study results for trastuzumab biosimilars have also been published. The digitization of patient care provides the first results on quality of life and prognosis of patients with advanced cancer. Digital communications between patients and physicians are being evaluated in several studies in Germany. As the discussion about patient-relevant endpoints for patients in the metastatic setting continues, overall survival rates from studies of big endocrine-based therapies are urgently needed. Preliminary analyses of small study cohorts offer initial insights. In the context of improving patient care, in the coming years, questions will center on which patients particularly benefit from certain therapies and which patients need particular protection from specific side effects. Questions about these predictors are raised in many scientific projects as attention increasingly focuses on this topic. PMID:29269955

Magma oceanography. I - Thermal evolution. [of lunar surface

NASA Technical Reports Server (NTRS)

Solomon, S. C.; Longhi, J.

1977-01-01

Fractional crystallization and flotation of cumulate plagioclase in a cooling 'magma ocean' provides the simplest explanation for early emplacement of a thick feldspar-rich lunar crust. The complementary mafic cumulates resulting from the differentiation of such a magma ocean have been identified as the ultimate source of mare basalt liquids on the basis or rare-earth abundance patterns and experimental petrology studies. A study is conducted concerning the thermal evolution of the early differentiation processes. A range of models of increasing sophistication are considered. The models developed contain the essence of the energetics and the time scale for magma ocean differentiation. Attention is given to constraints on a magma ocean, modeling procedures, single-component magma oceans, fractionating magma oceans, and evolving magma oceans.

Connecting Ocean Heat Transport Changes from the Midlatitudes to the Arctic Ocean

NASA Astrophysics Data System (ADS)

Hezel, P.; Nummelin, A.; Li, C.

2017-12-01

Under greenhouse warming, climate models simulate a weakening of the Atlantic Meridional Overturning Circulation and the associated ocean heat transport at midlatitudes but an increase in the ocean heat transport to the Arctic Ocean. These opposing trends lead to what could appear to be a discrepancy in the reported ocean contribution to Arctic amplification. This study clarifies how ocean heat transport affects Arctic climate under strong greenhouse warming using a set of the 21st century simulations performed within the Coupled Model Intercomparison Project. The results suggest that a future reduction in subpolar ocean heat loss enhances ocean heat transport to the Arctic Ocean, driving an increase in Arctic Ocean heat content and contributing to the intermodel spread in Arctic amplification. The results caution against extrapolating the forced oceanic signal from the midlatitudes to the Arctic.

SPURS: Salinity Processes in the Upper-Ocean Regional Study: THE NORTH ATLANTIC EXPERIMENT

NASA Technical Reports Server (NTRS)

Lindstrom, Eric; Bryan, Frank; Schmitt, Ray

2015-01-01

In this special issue of Oceanography, we explore the results of SPURS-1, the first part of the ocean process study Salinity Processes in the Upper-ocean Regional Study (SPURS). The experiment was conducted between August 2012 and October 2013 in the subtropical North Atlantic and was the first of two experiments (SPURS come in pairs!). SPURS-2 is planned for 20162017 in the tropical eastern Pacific Ocean.

Mission to Planet Earth. The living ocean: Observing ocean color from space

NASA Technical Reports Server (NTRS)

1994-01-01

Measurements of ocean color are part of NASA's Mission to Planet Earth, which will assess how the global environment is changing. Using the unique perspective available from space, NASA will observe, monitor, and study large-scale environmental processes, focusing on quantifying climate change. NASA will distribute the results of these studies to researchers worldwide to furnish a basis for informed decisions on environmental protection and economic policy. This information packet includes discussion on the reasons for measuring ocean color, the carbon cycle and ocean color, priorities for global climate research, and SeWiFS (sea-viewing wide field-of-view sensor) global ocean color measurements.

Maximum Drawdown of Atmospheric CO2 due to Biological Uptake in the Ocean and the Ocean Temperature Effect

NASA Astrophysics Data System (ADS)

Odalen, M.; Nycander, J.; Oliver, K. I. C.; Nilsson, J.; Brodeau, L.; Ridgwell, A.

2016-02-01

During glacials, atmospheric CO2 is significantly lowered; the decrease is about 1/3 or 90 ppm during the last four glacial cycles. Since the ocean reservoir of carbon, and hence the ocean capacity for storing carbon, is substantially larger than the atmospheric and terrestrial counterparts, it is likely that this lowering was caused by ocean processes, drawing the CO2 into the deep ocean. The Southern Ocean circulation and biological efficiency are widely accepted as having played an important part in this CO2 drawdown. However, the relative effects of different processes contributing to this oceanic uptake have not yet been well constrained. In this work, we focus on better constraining two of these processes; 1) the effect of increased efficiency of the biological carbon uptake, and 2) the effect of changes in global mean ocean temperature on the abiotic ocean-atmosphere CO2 equilibrium. By performing ensemble runs using an Earth System Model of Intermediate Complexity (EMIC) we examine the changes in atmospheric pCO2 achieved by 100% nutrient utilization efficiency of biology. The simulations display different ocean circulation patterns and hence different global ocean mean temperatures. By restoring the atmospheric pCO2 to a target value during the spin-up phase, the total carbon content differs between each of the ensemble members. The difference is due to circulation having direct effects on biology, but also on global ocean mean temperature, changing the solubility of CO2. This study reveals the relative importance of of the processes 1 and 2 (mentioned above) for atmospheric pCO2 in a changed climate. The results of this study also show that a difference in carbon content after spin-up can have a significant effect on the drawdown potential of a maximised biological efficiency. Thus, the choice of spin-up characteristics in a model study of climate change CO2 dynamics may significantly affect the outcome of the study.

Role of cooperative groups and funding source in clinical trials supporting guidelines for systemic therapy of breast cancer.

PubMed

Tibau, Ariadna; Anguera, Geòrgia; Andrés-Pretel, Fernando; Templeton, Arnoud J; Seruga, Bostjan; Barnadas, Agustí; Amir, Eitan; Ocana, Alberto

2018-03-13

Clinical research is conducted by academia, cooperative groups (CGs) or pharmaceutical industry. Here, we evaluate the role of CGs and funding sources in the development of guidelines for breast cancer therapies. We identified 94 studies. CGs were involved in 28 (30%) studies while industry either partially or fully sponsored 64 (68%) studies. The number of industry funded studies increased over time (from 0% in 1976 to 100% in 2014; p for trend = 0.048). Only 10 (11%) government or academic studies were identified. Studies conducted by GCs included a greater number of subjects (median 448 vs. 284; p = 0.015), were more common in the neo/adjuvant setting ( p < 0.0001), and were more often randomized ( p = 0.018) phase III ( p < 0.0001) trials. Phase III trial remained significant predictor for CG-sponsored trials (OR 7.1 p = 0.004) in a multivariable analysis. Industry funding was associated with higher likelihood of positive outcomes favoring the sponsored experimental arm ( p = 0.013) but this relationship was not seen for CG-sponsored trials ( p = 0.53). ASCO, ESMO, and NCCN guidelines were searched to identify systemic anti-cancer therapies for early-stage and metastatic breast cancer. Trial characteristics and outcomes were collected. We identified sponsors and/or the funding source(s) and determined whether CGs, industry, or government or academic institutions were involved. Chi-square tests were used for comparison between studies. Industry funding is present in the majority of studies providing the basis for which recommendations about treatment of breast cancer are made. Industry funding, but not CG-based funding, was associated with higher likelihood of positive outcomes in clinical studies supporting guidelines for systemic therapy.

Activity Book: Ocean Ecology.

ERIC Educational Resources Information Center

Learning, 1992

1992-01-01

Presents a collection of activities to help elementary students study ocean ecology. The activities have students investigate ocean inhabitants, analyze animal adaptations, examine how temperature and saltiness affect ocean creatures, and learn about safeguarding the sea. Student pages offer reproducible learning sheets. (SM)

Ocean transport and variability studies of the South Pacific, Southern, and Indian Oceans

NASA Technical Reports Server (NTRS)

Church, John A.; Cresswell, G. R.; Nilsson, C. S.; Mcdougall, T. J.; Coleman, R.; Rizos, C.; Penrose, J.; Hunter, J. R.; Lynch, M. J.

1991-01-01

The objectives of this study are to analyze ocean dynamics in the western South Pacific and the adjacent Southern Ocean and the eastern Indian Ocean. Specifically, our objectives for these three regions are, for the South Pacific Ocean: (1) To estimate the volume transport of the east Australian Current (EAC) along the Australian coast and in the Tasman Front, and to estimate the time variability (on seasonal and interannual time scales) of this transport. (2) To contribute to estimating the meridional heat and freshwater fluxes (and their variability) at about 30 deg S. Good estimates of the transport in the western boundary current are essential for accurate estimates of these fluxes. (3) To determine how the EAC transport (and its extension, the Tasman Front and the East Auckland Current) closes the subtropical gyre of the South Pacific and to better determine the structure at the confluence of this current and the Antarctic Circumpolar Current. (4) To examine the structure and time variability of the circulation in the western South Pacific and the adjacent Southern Ocean, particularly at the Tasman Front. For the Indian Ocean: (5) To study the seasonal interannual variations in the strength of the Leeuwin Current. (6) To monitor the Pacific-Indian Ocean throughflow and the South Equatorial and the South Java Currents between northwest Australia and Indonesia. (7) To study the processes that form the water of the permanent oceanic thermocline and, in particular, the way in which new thermocline water enters the permanent thermocline in late winter and early spring as the mixed layer restratifies. For the Southern Ocean: (8) To study the mesoscale and meridional structure of the Southern Ocean between 150 deg E and 170 deg E; in particular, to describe the Antarctic frontal system south of Tasmania and determine its interannual variability; to estimate the exchanges of heat, salt, and other properties between the Indian and Pacific Oceans; and to investigate the annual ventilation of the Antarctic Intermediate Water and Subantarctic Mode Water Masses.

Spaceborne studies of ocean circulation

NASA Technical Reports Server (NTRS)

Patzert, W. C.

1984-01-01

The history and near-term future of ocean remote sensing to study ocean circulation are examined. Seasat provided the first-ever global data sets of sea surface topography (altimeter) and marine winds (scatterometer) and laid the foundation for the next generation of satellite missions planned for the late 1980s. The future missions are the next generation of altimeter and scatterometer to be flown aboard TOPEX (TOPography EXperiment) and NROSS (Navy Remote Sensing System), respectively. The data from these satellites will be coordinated with measurements made at sea to determine the driving forces of ocean circulation and to study the oceans' role in climate variability. The significance of such studies to such matters as climatic changes, fisheries, commerce, waste disposal, and national defense is noted.

Upper ocean response to Hurricane Gonzalo (2014): Salinity effects revealed by targeted and sustained underwater glider observations

NASA Astrophysics Data System (ADS)

Domingues, Ricardo; Goni, Gustavo; Bringas, Francis; Lee, Sang-Ki; Kim, Hyun-Sook; Halliwell, George; Dong, Jili; Morell, Julio; Pomales, Luis

2015-09-01

During October 2014, Hurricane Gonzalo traveled within 85 km from the location of an underwater glider situated north of Puerto Rico. Observations collected before, during, and after the passage of this hurricane were analyzed to improve our understanding of the upper ocean response to hurricane winds. The main finding in this study is that salinity potentially played an important role on changes observed in the upper ocean; a near-surface barrier layer likely suppressed the hurricane-induced upper ocean cooling, leading to smaller than expected temperature changes. Poststorm observations also revealed a partial recovery of the ocean to prestorm conditions 11 days after the hurricane. Comparison with a coupled ocean-atmosphere hurricane model indicates that model-observations discrepancies are largely linked to salinity effects described. Results presented in this study emphasize the value of underwater glider observations for improving our knowledge of how the ocean responds to tropical cyclone winds and for tropical cyclone intensification studies and forecasts.

The Influence of Ice-Ocean Interactions on Europa's Overturning Circulation

NASA Astrophysics Data System (ADS)

Zhu, P.; Manucharyan, G. E.; Thompson, A. F.; Goodman, J. C.; Vance, S.

2016-12-01

Jupiter's moon Europa appears to have a global liquid ocean, which is located beneath an ice shell that covers the moon's entire surface. Linking ocean dynamics and ice-ocean interactions is crucial to understanding observed surface features on Europa as well as other satellite measurements. Ocean properties and circulation may also provide clues as to whether the moon has the potential to support extraterrestrial life through chemical transport governed by ice-ocean interactions. Previous studies have identified a Hadley cell-like overturning circulation extending from the equator to mid latitudes. However, these model simulations do not consider ice-ocean interactions. In this study, our goal is to investigate how the ocean circulation may be affected by ice. We study two ice-related processes by building idealized models. One process is horizontal convection driven by an equator-to-pole buoyancy difference due to latitudinal ice transport at the ocean surface, which is found to be much weaker than the convective overturning circulation. The second process we consider is the freshwater layer formed by ice melting at the equator. A strong buoyancy contrast between the freshwater layer and the underlying water suppresses convection and turbulent mixing, which may modify the surface heat flux from the ocean to the bottom of the ice. We find that the salinity of the ocean below the freshwater layer tends to be homogeneous both vertically and horizontally with the presence of an overturning circulation. Critical values of circulation strength constrain the freshwater layer depth, and this relationship is sensitive to the average salinity of the ocean. Further coupling of temperature and salinity of the ice and the ocean that includes mutual influences between the surface heat flux and the freshwater layer may provide additional insights into the ice-ocean feedback, and its influence on the latitudinal difference of heat transport.

Effects of Earth's rotation on the early differentiation of a terrestrial magma ocean

NASA Astrophysics Data System (ADS)

Maas, Christian; Hansen, Ulrich

2015-11-01

Similar to other terrestrial planets like Moon and Mars, Earth experienced a magma ocean period about 4.5 billion years ago. On Earth differentiation processes in the magma ocean set the initial conditions for core formation and mantle evolution. During the magma ocean period Earth was rotating significantly faster than today. Further, the viscosity of the magma was low, thus that planetary rotation potentially played an important role for differentiation. However, nearly all previous studies neglect rotational effects. All in all, our results suggest that planetary rotation plays an important role for magma ocean crystallization. We employ a 3-D numerical model to study crystal settling in a rotating and vigorously convecting early magma ocean. We show that crystal settling in a terrestrial magma ocean is crucially affected by latitude as well as by rotational strength and crystal density. Due to rotation an inhomogeneous accumulation of crystals during magma ocean solidification with a distinct crystal settling between pole and equator could occur. One could speculate that this may have potentially strong effects on the magma ocean solidification time and the early mantle composition. It could support the development of a basal magma ocean and the formation of anomalies at the core-mantle boundary in the equatorial region, reaching back to the time of magma ocean solidification.

Recent Ocean Literacy Research in United States Public Schools: Results and Implications

ERIC Educational Resources Information Center

Plankis, Brian J.; Marrero, Meghan E.

2010-01-01

Recent research conducted on adults in the United States indicates low ocean literacy (Ocean Project, 2009b, 1999), but there is a dearth of peer-reviewed research on K-12 students' ocean literacy. This paper presents two research studies that examined the ocean and environmental literacy of 464 K-12 students in five states. Like the majority of…

NASA Simulation Shows Ocean Turbulence in the North Atlantic

NASA Image and Video Library

2018-02-21

This image shows a simulated snapshot of ocean turbulence in the North Atlantic Ocean in March 2012, from a groundbreaking super-high-resolution global ocean simulation (approximately 1.2 miles, or 2 kilometers, horizontal resolution) developed at JPL (http://wwwcvs.mitgcm.org/viewvc/MITgcm/MITgcm_contrib/llc_hires/llc_4320/). The colors represent the magnitude of surface relative vorticity, a measure of the spin of fluid parcels. The image emphasizes fast-rotating, small-scale (defined here as 6.2 to 31-mile, or 10 to 50 kilometer, range) turbulence, especially during the winter. High levels of relative vorticity caused by small-scale turbulence are believed to strongly transport heat and carbon vertically in the ocean. The image appears in a study (Su et al. 2018), entitled "Ocean submesoscales as a key component of the global heat budget," published recently in Nature Communications. The study suggests that upper-ocean small-scale turbulence transports heat upward in the ocean at a level five times larger than larger-scale heat transport by ocean eddies, significantly affecting the exchange of heat between the ocean interior and atmosphere. Such interactions have a crucial impact on the Earth's climate. A movie is available at https://photojournal.jpl.nasa.gov/catalog/PIA22256

The importance of planetary rotation period for ocean heat transport.

PubMed

Cullum, J; Stevens, D; Joshi, M

2014-08-01

The climate and, hence, potential habitability of a planet crucially depends on how its atmospheric and ocean circulation transports heat from warmer to cooler regions. However, previous studies of planetary climate have concentrated on modeling the dynamics of atmospheres, while dramatically simplifying the treatment of oceans, which neglects or misrepresents the effect of the ocean in the total heat transport. Even the majority of studies with a dynamic ocean have used a simple so-called aquaplanet that has no continental barriers, which is a configuration that dramatically changes the ocean dynamics. Here, the significance of the response of poleward ocean heat transport to planetary rotation period is shown with a simple meridional barrier--the simplest representation of any continental configuration. The poleward ocean heat transport increases significantly as the planetary rotation period is increased. The peak heat transport more than doubles when the rotation period is increased by a factor of ten. There are also significant changes to ocean temperature at depth, with implications for the carbon cycle. There is strong agreement between the model results and a scale analysis of the governing equations. This result highlights the importance of both planetary rotation period and the ocean circulation when considering planetary habitability.

SEASAT economic assessment. Volume 8: Ocean fishing case study. [economic benefits of SEASAT satellites to ocean fishing industries in the United States and Canada

NASA Technical Reports Server (NTRS)

1975-01-01

The potential application of SEASAT data with regard to ocean fisheries is discussed. Tracking fish populations, indirect assistance in forecasting expected populations and assistance to fishing fleets in avoiding costs incurred due to adverse weather through improved ocean conditions forecasts were investigated. Case studies on fisheries in the United States and Canada are cited.

Promoting Ocean Literacy through American Meteorological Society Programs

NASA Astrophysics Data System (ADS)

Passow, Michael; Abshire, Wendy; Weinbeck, Robert; Geer, Ira; Mills, Elizabeth

2017-04-01

American Meteorological Society Education Programs provide course materials, online and physical resources, educator instruction, and specialized training in ocean, weather, and climate sciences (https://www.ametsoc.org/ams/index.cfm/education-careers/education-program/k-12-teachers/). Ocean Science literacy efforts are supported through the Maury Project, DataStreme Ocean, and AMS Ocean Studies. The Maury Project is a summer professional development program held at the US Naval Academy designed to enhance effective teaching of the science, technology, engineering, and mathematics of oceanography. DataStreme Ocean is a semester-long course offered twice a year to participants nationwide. Created and sustained with major support from NOAA, DS Ocean explores key concepts in marine geology, physical and chemical oceanography, marine biology, and climate change. It utilizes electronically-transmitted text readings, investigations and current environmental data. AMS Ocean Studies provides complete packages for undergraduate courses. These include online textbooks, investigations manuals, RealTime Ocean Portal (course website), and course management system-compatible files. It can be offered in traditional lecture/laboratory, completely online, and hybrid learning environments. Assistance from AMS staff and other course users is available.

A Note on the Relationship of Temperature and Water Vapor over Oceans, as well as the Sea Surface Temperature Impact

NASA Technical Reports Server (NTRS)

Shie, C.-L.; Tao, W.-K.; Simpson, J.

2005-01-01

This note follows up on a recent study by Shie et al. (2005) and extends the investigation of the domain-averaged moisture-temperature (Q-T) relationship from the Tropics (i.e., the previous study) to the tropical Pacific, Atlantic and Indian Oceans. The Q and T data examined in this study are obtained from the GEOS-3 [Goddard Earth Observing System Version-3] global re-analysis monthly products. Similar to what was found earlier in the Tropics, Q is also found to increase with T over the entire oceanic region; however, Q increases faster with T over oceans than over the Tropics. The Q-T distribution for the Tropics is in a quasi-linear relationship, which is embedded in a global Q-T distribution that is, however, in a more complex curvilinear relationship. The Q-T distribution over the oceanic regions seems to fall within the lower bound (ie., the relatively colder and driver regime) of the tropical Q-T distribution. T over oceans is also found increasing with SST (sea surface temperature), which seemingly implies that an air mass might have gained heat more readily from a warmer ocean as compared to a colder ocean. Q is also found to increase with SST in a manner that quantitatively resembles an earlier finding by Stevens (1990). We also found that relative humidity exhibits similar behaviors for oceanic and tropical regions, respectively, i.e., it increases with both SST and T over oceans and increases with T in the Tropics (Shie et al. 2005). All these similar features found between oceanic and tropical regions seem to inform us that oceans occupy most of the Tropics and so play a key role in determining what have happened in the Tropics.

Contrasting Indian Ocean SST Variability With and Without ENSO Influence: A Coupled Atmosphere-Ocean GCM Study

NASA Technical Reports Server (NTRS)

Yu, Jin-Yi; Lau, K. M.

2004-01-01

In this study, we perform experiments with a coupled atmosphere-ocean general circulation model (CGCM) to examine ENSO's influence on the interannual sea surface temperature (SST) variability of the tropical Indian Ocean. The control experiment includes both the Indian and Pacific Oceans in the ocean model component of the CGCM (the Indo-Pacific Run). The anomaly experiment excludes ENSOs influence by including only the Indian Ocean while prescribing monthly-varying climatological SSTs for the Pacific Ocean (the Indian-Ocean Run). In the Indo-Pacific Run, an oscillatory mode of the Indian Ocean SST variability is identified by a multi-channel singular spectral analysis (MSSA). The oscillatory mode comprises two patterns that can be identified with the Indian Ocean Zonal Mode (IOZM) and a basin-wide warming/cooling mode respectively. In the model, the IOZM peaks about 3-5 months after ENSO reaches its maximum intensity. The basin mode peaks 8 months after the IOZM. The timing and associated SST patterns suggests that the IOZM is related to ENSO, and the basin- wide warming/cooling develops as a result of the decay of the IOZM spreading SST anomalies from western Indian Ocean to the eastern Indian Ocean. In contrast, in the Indian-Ocean Run, no oscillatory modes can be identified by the MSSA, even though the Indian Ocean SST variability is characterized by east-west SST contrast patterns similar to the IOZM. In both control and anomaly runs, IOZM-like SST variability appears to be associated with forcings from fluctuations of the Indian monsoon. Our modeling results suggest that the oscillatory feature of the IOZM is primarily forced by ENSO.

Correlation of cetuximab-induced skin rash and outcomes of solid tumor patients treated with cetuximab: a systematic review and meta-analysis.

PubMed

Abdel-Rahman, Omar; Fouad, Mona

2015-02-01

We performed a systematic review and meta-analysis of the correlation between cetuximab-induced skin rash and outcomes of solid tumor patients treated with cetuximab. Eligible studies included phase I, II and III trials of patients with solid tumors on cetuximab; describing events of skin rash and correlating skin rash with overall survival (OS), progression free survival (PFS) and/or overall response rate (ORR). Our search strategy yielded 409 potentially relevant citations on CETUXIMAB from Pubmed/Medline, CENTRAL Cochrane registry and ASCO meeting library. After exclusion of ineligible studies, a total of 13 clinical trials were considered eligible for the meta-analysis, including 4 phase III trials, 8 phase II trials and one phase I trial. The occurrence of cetuximab-induced rash in patients was highly associated with improvements in PFS (HR=0.74; 95% CI: 0.63-0.86, P<0.0002), OS (HR=0.60; 95% CI: 0.47-0.76, P<0.0001), and ORR (RR=1.51, 95% CI: 1.26-1.81, P<0.00001), as compared to patients without rash. Exploratory subgroup analysis showed no effect of tumor types on the RR of ORR. Our meta-analysis has demonstrated that cetuximab-induced rash is associated with a significantly improved OS, PFS and ORR. Cetuximab-induced skin rash may represent a prognostic factor in patients with advanced solid tumors. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

The National Cancer Institute-American Society of Clinical Oncology Cancer Trial Accrual Symposium: summary and recommendations.

PubMed

Denicoff, Andrea M; McCaskill-Stevens, Worta; Grubbs, Stephen S; Bruinooge, Suanna S; Comis, Robert L; Devine, Peggy; Dilts, David M; Duff, Michelle E; Ford, Jean G; Joffe, Steven; Schapira, Lidia; Weinfurt, Kevin P; Michaels, Margo; Raghavan, Derek; Richmond, Ellen S; Zon, Robin; Albrecht, Terrance L; Bookman, Michael A; Dowlati, Afshin; Enos, Rebecca A; Fouad, Mona N; Good, Marjorie; Hicks, William J; Loehrer, Patrick J; Lyss, Alan P; Wolff, Steven N; Wujcik, Debra M; Meropol, Neal J

2013-11-01

Many challenges to clinical trial accrual exist, resulting in studies with inadequate enrollment and potentially delaying answers to important scientific and clinical questions. The National Cancer Institute (NCI) and the American Society of Clinical Oncology (ASCO) cosponsored the Cancer Trial Accrual Symposium: Science and Solutions on April 29-30, 2010 to examine the state of accrual science related to patient/community, physician/provider, and site/organizational influences, and identify new interventions to facilitate clinical trial enrollment. The symposium featured breakout sessions, plenary sessions, and a poster session including 100 abstracts. Among the 358 attendees were clinical investigators, researchers of accrual strategies, research administrators, nurses, research coordinators, patient advocates, and educators. A bibliography of the accrual literature in these three major areas was provided to participants in advance of the meeting. After the symposium, the literature in these areas was revisited to determine if the symposium recommendations remained relevant within the context of the current literature. Few rigorously conducted studies have tested interventions to address challenges to clinical trials accrual. Attendees developed recommendations for improving accrual and identified priority areas for future accrual research at the patient/community, physician/provider, and site/organizational levels. Current literature continues to support the symposium recommendations. A combination of approaches addressing both the multifactorial nature of accrual challenges and the characteristics of the target population may be needed to improve accrual to cancer clinical trials. Recommendations for best practices and for future research developed from the symposium are provided.

The Living Ocean. SeaWiFS: Studying Ocean Color from Space. Teacher's Guide with Activities

NASA Technical Reports Server (NTRS)

1994-01-01

This educational document, designed for grades 9 to 10, discusses the observation of oceans from space. Topics covered include ocean color, the role of phytoplankton, the carbon cycle, and the greenhouse effect. Activities and discussion questions are presented.

Methods of testing parameterizations: Vertical ocean mixing

NASA Technical Reports Server (NTRS)

Tziperman, Eli

1992-01-01

The ocean's velocity field is characterized by an exceptional variety of scales. While the small-scale oceanic turbulence responsible for the vertical mixing in the ocean is of scales a few centimeters and smaller, the oceanic general circulation is characterized by horizontal scales of thousands of kilometers. In oceanic general circulation models that are typically run today, the vertical structure of the ocean is represented by a few tens of discrete grid points. Such models cannot explicitly model the small-scale mixing processes, and must, therefore, find ways to parameterize them in terms of the larger-scale fields. Finding a parameterization that is both reliable and plausible to use in ocean models is not a simple task. Vertical mixing in the ocean is the combined result of many complex processes, and, in fact, mixing is one of the less known and less understood aspects of the oceanic circulation. In present models of the oceanic circulation, the many complex processes responsible for vertical mixing are often parameterized in an oversimplified manner. Yet, finding an adequate parameterization of vertical ocean mixing is crucial to the successful application of ocean models to climate studies. The results of general circulation models for quantities that are of particular interest to climate studies, such as the meridional heat flux carried by the ocean, are quite sensitive to the strength of the vertical mixing. We try to examine the difficulties in choosing an appropriate vertical mixing parameterization, and the methods that are available for validating different parameterizations by comparing model results to oceanographic data. First, some of the physical processes responsible for vertically mixing the ocean are briefly mentioned, and some possible approaches to the parameterization of these processes in oceanographic general circulation models are described in the following section. We then discuss the role of the vertical mixing in the physics of the large-scale ocean circulation, and examine methods of validating mixing parameterizations using large-scale ocean models.

National Ocean Sciences Bowl in 2014: A National Competition for High School Ocean Science Education

DTIC Science & Technology

2015-03-31

the 2014 National Finals Competition. The Finals were held May 1-4, 2014 in Seattle, WA with a theme of ocean acidification . A longitudinal study and...Washington (UW) in Seattle, WA on May 1-4, 2014. The theme for the 2014 Finals Competition was ocean acidification , exploring the progressive increase in...and environmental and societal effects of ocean acidification . They became more aware of ocean acidification’s potential to disrupt ecosystems in a

Satellite altimetric measurements of the ocean. Report of the TOPEX Science Working Group

NASA Technical Reports Server (NTRS)

Stewart, R.

1981-01-01

The scientific usefulness of satellite measurements of ocean topography for the study of ocean circulation was investigated. The following topics were studied: (1) scientific problems which use altimetric measurements of ocean topography; (2) the extent in which in situ measurements are complementary or required; (3) accuracy, precision, and spatial and temporal resolutions which are required of the topographic measurements; (4) errors associated with measurement techniques; and (5) influences of these errors on scientific problems. An operational system for measuring ocean topography, was defined and the cost of conducting such a topographic experiment, was estimated.

Measuring Ocean Literacy in Pre-Service Teachers: Psychometric Properties of the Greek Version of the Survey of Ocean Literacy and Experience (SOLE)

ERIC Educational Resources Information Center

Markos, Angelos; Boubonari, Theodora; Mogias, Athanasios; Kevrekidis, Theodoros

2017-01-01

The aim of the present study was to respond to the increasing demand for comprehensive tools for the measurement of ocean literacy, by investigating the psychometric characteristics of a Greek version of the Survey of Ocean Literacy and Experience (SOLE), an instrument that assesses conceptual understanding of general ocean sciences content,…

Oceanography in the formal and informal classroom

NASA Technical Reports Server (NTRS)

Richardson, A.; Jasnow, M.; Srinivasan, M.; Rosmorduc, V.; Blanc, F.

2002-01-01

The TOPEX/Poseidon and Jason-1 ocean altimeter missions offer the educator in the middle school or informal education venue a unique opportunity for reinforcing ocean science studies. An educational poster from NASA's Jet Propulsion Laboratory and France's Centre National d'Etudes Spatiales provide teachers and students a tool to examine topics such as the dynamics of ocean circulation, ocean research, and the oceans' role in climate.

Depth of origin of ocean-circulation-induced magnetic signals

NASA Astrophysics Data System (ADS)

Irrgang, Christopher; Saynisch-Wagner, Jan; Thomas, Maik

2018-01-01

As the world ocean moves through the ambient geomagnetic core field, electric currents are generated in the entire ocean basin. These oceanic electric currents induce weak magnetic signals that are principally observable outside of the ocean and allow inferences about large-scale oceanic transports of water, heat, and salinity. The ocean-induced magnetic field is an integral quantity and, to first order, it is proportional to depth-integrated and conductivity-weighted ocean currents. However, the specific contribution of oceanic transports at different depths to the motional induction process remains unclear and is examined in this study. We show that large-scale motional induction due to the general ocean circulation is dominantly generated by ocean currents in the upper 2000 m of the ocean basin. In particular, our findings allow relating regional patterns of the oceanic magnetic field to corresponding oceanic transports at different depths. Ocean currents below 3000 m, in contrast, only contribute a small fraction to the ocean-induced magnetic signal strength with values up to 0.2 nT at sea surface and less than 0.1 nT at the Swarm satellite altitude. Thereby, potential satellite observations of ocean-circulation-induced magnetic signals are found to be likely insensitive to deep ocean currents. Furthermore, it is shown that annual temporal variations of the ocean-induced magnetic field in the region of the Antarctic Circumpolar Current contain information about sub-surface ocean currents below 1000 m with intra-annual periods. Specifically, ocean currents with sub-monthly periods dominate the annual temporal variability of the ocean-induced magnetic field.

Recent changes in the summer monsoon circulation and their impact on dynamics and thermodynamics of the Arabian Sea

NASA Astrophysics Data System (ADS)

Pratik, Kad; Parekh, Anant; Karmakar, Ananya; Chowdary, Jasti S.; Gnanaseelan, C.

2018-05-01

The present study examines changes in the low-level summer monsoon circulation over the Arabian Sea and their impact on the ocean dynamics using reanalysis data. The study confirms intensification and northward migration of low-level jet during 1979 to 2015. Further during the study period, an increase in the Arabian Sea upper ocean heat content is found in spite of a decreasing trend in the net surface heat flux, indicating the possible role of ocean dynamics in the upper ocean warming. Increase in the anti-cyclonic wind stress curl associated with the change in the monsoon circulation induces downwelling over the central Arabian Sea, favoring upper ocean warming. The decreasing trend of southward Ekman transport, a mechanism transporting heat from the land-locked north Indian Ocean to southern latitudes, also supports increasing trend of the upper ocean heat content. To reinstate and quantify the role of changing monsoon circulation in increasing the heat content over the Arabian Sea, sensitivity experiment is carried out using ocean general circulation model. In this experiment, the model is forced by inter-annual momentum forcing while rest of the forcing is climatological. Experiment reveals that the changing monsoon circulation increases the upper ocean heat content, effectively by enhancing downwelling processes and reducing southward heat transport, which strongly endorses our hypothesis that changing ocean dynamics associated with low-level monsoon circulation is causing the increasing trend in the heat content of the Arabian Sea.

Excerpt from a Forthcoming Book. The Ocean Book: Dive In--The Beginning of Your Ocean Study.

ERIC Educational Resources Information Center

Science Activities, 1989

1989-01-01

Six activities complete with reproducible worksheets are presented. Materials and procedures for each are listed. Answers to the quiz and crossword puzzle are included. Topics include the water cycle, the world's oceans, the ocean floor, and fish. (CW)

A New Desalination Pump Helps Define the pH of Ocean Worlds

NASA Astrophysics Data System (ADS)

Levi, A.; Sasselov, D.

2018-04-01

We study ocean exoplanets, for which the global surface ocean is separated from the rocky interior by a high-pressure ice mantle. We describe a mechanism that can pump salts out of the ocean, resulting in oceans of very low salinity. Here we focus on the H2O–NaCl system, though we discuss the application of this pump to other salts as well. We find our ocean worlds to be acidic, with a pH in the range of 2–4. We discuss and compare between the conditions found within our studied oceans and the conditions in which polyextremophiles were discovered. This work focuses on exoplanets in the super-Earth mass range (∼2 M ⊕), with water composing at least a few percent of their mass. However, the principle of the desalination pump might extend beyond this mass range.

Investigating Undergraduate Science Students’ Conceptions and Misconceptions of Ocean Acidification

PubMed Central

Danielson, Kathryn I.; Tanner, Kimberly D.

2015-01-01

Scientific research exploring ocean acidification has grown significantly in past decades. However, little science education research has investigated the extent to which undergraduate science students understand this topic. Of all undergraduate students, one might predict science students to be best able to understand ocean acidification. What conceptions and misconceptions of ocean acidification do these students hold? How does their awareness and knowledge compare across disciplines? Undergraduate biology, chemistry/biochemistry, and environmental studies students, and science faculty for comparison, were assessed on their awareness and understanding. Results revealed low awareness and understanding of ocean acidification among students compared with faculty. Compared with biology or chemistry/biochemistry students, more environmental studies students demonstrated awareness of ocean acidification and identified the key role of carbon dioxide. Novel misconceptions were also identified. These findings raise the question of whether undergraduate science students are prepared to navigate socioenvironmental issues such as ocean acidification. PMID:26163563

Global Health Initiatives of the International Oncology Community.

PubMed

Al-Sukhun, Sana; de Lima Lopes, Gilberto; Gospodarowicz, Mary; Ginsburg, Ophira; Yu, Peter Paul

2017-01-01

Cancer has become one of the leading causes of morbidity and mortality in low- and middle-income countries (LMICs), where 60% of the world's total new cases are diagnosed. The challenge for effective control of cancer is multifaceted. It mandates integration of effective cancer prevention, encouraging early detection, and utilization of resource-adapted therapeutic and supportive interventions. In the resource-constrained setting, it becomes challenging to deliver each service optimally, and efficient allocation of resources is the best way to improve the outcome. This concept was translated into action through development of resource-stratified guidelines, pioneered by the Breast Health Global Initiative (BHGI), and later adopted by most oncology societies in an attempt to help physicians deliver the best possible care in a limited-resource setting. Improving outcome entails collaboration between key stakeholders, including the pharmaceutical industry, local and national health authorities, the World Health Organization (WHO), and other nonprofit, patient-oriented organizations. Therefore, we started to observe global health initiatives-led by ASCO, the Union for International Cancer Control (UICC), and the WHO-to address these challenges at the international level. This article discusses some of these initiatives.

Re-excision rates after breast conserving surgery following the 2014 SSO-ASTRO guidelines.

PubMed

Heelan Gladden, Alicia A; Sams, Sharon; Gleisner, Ana; Finlayson, Christina; Kounalakis, Nicole; Hosokawa, Patrick; Brown, Regina; Chong, Tae; Mathes, David; Murphy, Colleen

2017-12-01

In 2014, SSO-ASTRO published guidelines which recommended "no ink on tumor" as adequate margins for patients undergoing breast conservation for invasive breast cancer. In 2016, new SSO-ASTRO-ASCO guidelines recommended 2 mm margins for DCIS. We evaluated whether these guidelines affected re-excision rates at our institution. Patients treated with breast conservation surgery from January 1, 2010-March 1, 2016 were identified. Re-excision rates, tumor characteristics, and presence of residual disease were recorded. The 2016 guidelines were retrospectively applied to the same cohort and expected re-excision rates calculated. Re-excision rates did not significantly decline before and after 2014 guideline adoption (11.9% before, 10.9% after; p = 0.65) or when the 2016 guidelines were retrospectively applied (8.4%; p = 0.10). The 2014 and 2016 guidelines had minimal impact on our re-excision rates, as most re-excisions were done for DCIS and 2016 guidelines supported our prior institutional practices of 2 mm margins for these patients. Copyright © 2017 Elsevier Inc. All rights reserved.

Opportunities for Breakthroughs in Large-Scale Computational Simulation and Design

NASA Technical Reports Server (NTRS)

Alexandrov, Natalia; Alter, Stephen J.; Atkins, Harold L.; Bey, Kim S.; Bibb, Karen L.; Biedron, Robert T.; Carpenter, Mark H.; Cheatwood, F. McNeil; Drummond, Philip J.; Gnoffo, Peter A.

2002-01-01

Opportunities for breakthroughs in the large-scale computational simulation and design of aerospace vehicles are presented. Computational fluid dynamics tools to be used within multidisciplinary analysis and design methods are emphasized. The opportunities stem from speedups and robustness improvements in the underlying unit operations associated with simulation (geometry modeling, grid generation, physical modeling, analysis, etc.). Further, an improved programming environment can synergistically integrate these unit operations to leverage the gains. The speedups result from reducing the problem setup time through geometry modeling and grid generation operations, and reducing the solution time through the operation counts associated with solving the discretized equations to a sufficient accuracy. The opportunities are addressed only at a general level here, but an extensive list of references containing further details is included. The opportunities discussed are being addressed through the Fast Adaptive Aerospace Tools (FAAST) element of the Advanced Systems Concept to Test (ASCoT) and the third Generation Reusable Launch Vehicles (RLV) projects at NASA Langley Research Center. The overall goal is to enable greater inroads into the design process with large-scale simulations.

Heavy metal contamination in the Western Indian Ocean (a review)

NASA Astrophysics Data System (ADS)

Mamboya, F. A.; Pratap, H. B.; Björk, M.

2003-05-01

Western Indian Ocean Coast has many potential marine ecosystems such as mangrove, seagrass meadows, macroalgae, and coral reefs. It is largely unspoiled environment however, tourism and population growth in coastal urban centres, industrialization, are presenting a risk of pollutants input to the marine environment of the Western Indian Ocean. Mining, shipping and agricultural activities also input contaminants into the marine environment via runoff, vessel operations and accidental spillage. Heavy metals are among the pollutants that are expected to increase in the marine environment of the Western Indian Ocean. The increase in heavy metal pollution can pose a serious health problem to marine organism and human through food chain. This paper reviews studies on heavy metal contamination in the Western Indian Ocean. It covers heavy metal studies in the sediments, biota, particulates and seawater collected in different sites. In comparison to other regions, only few studies have been conducted in the Western Indian Ocean and are localized in some certain areas. Most of these studies were conducted in Kenyan and Tanzanian coasts while few of them were conducted in Mauritius, Somalia and Reunion. No standard or common method has been reported for the analysis or monitoring of heavy metals in the Western Indian Ocean.

Ocean Science for Decision-Making: Current Activities of the National Research Council's Ocean Studies Board

NASA Astrophysics Data System (ADS)

Roberts, S.; Glickson, D.; Mengelt, C.; Forrest, S.; Waddell, K.

2012-12-01

The National Research Council is a private, nonprofit organization chartered by Congress in 1916 as an expansion of the U.S. National Academy of Sciences. Its mission is to improve the use of science in government decision making and public policy, increase public understanding, and promote the acquisition and dissemination of knowledge in matters involving science, engineering, technology, and health. Within the National Research Council, the Ocean Studies Board (OSB) mission is to explore the science, policies, and infrastructure needed to understand, manage, and conserve coastal and marine environments and resources. OSB undertakes studies and workshops on emerging scientific and policy issues at the request of federal agencies, Congress, and others; provides program reviews and guidance; and facilitates communication on oceanographic issues among different sectors. OSB also serves as the U.S. National Committee to the international, nongovernmental Scientific Committee on Oceanic Research (SCOR). OSB has produced reports on a wide range of topics of interest to researchers and educators, the federal government, the non-profit sector, and industry. Recent reports have focused on ecosystem services in the Gulf of Mexico after the Deepwater Horizon oil spill, sea level rise on the U.S. west coast, scientific ocean drilling needs and accomplishments, requirements for sustained ocean color measurements, critical infrastructure for ocean research, tsunami warning and preparedness, ocean acidification, and marine and hydrokinetic power resource assessments. Studies that are currently underway include responding to oil spills in the Arctic, evaluating the effectiveness of fishery stock rebuilding plans, and reviewing the National Ocean Acidification Research Plan. OSB plays an important role in helping create policy decisions and disseminating important information regarding various aspects of ocean science.

Pelagic ecology of the South West Indian Ocean Ridge seamounts: Introduction and overview

NASA Astrophysics Data System (ADS)

Rogers, A. D.

2017-02-01

The Indian Ocean was described by Behrman (1981) as the "Forlorn Ocean", a region neglected by science up to the late-1950s. For example, the Challenger Expedition from 1872 to 1876 largely avoided the Indian Ocean, sailing from Cape Town into Antarctic waters sampling around the Prince Edward Islands, Kerguelen Island and Crozet Islands before heading to Melbourne. From 1876 to the 1950s there were expeditions on several vessels including the Valdivia, Gauss and Planet (Germany), the Snellius (Netherlands), Discovery II, MahaBiss (United Kingdom), Albatross (Sweden), Dana and Galathea (Denmark; Behrman, 1981). There was no coordination between these efforts and overall the Indian Ocean, especially the deep sea remained perhaps the most poorly explored of the world's oceans. This situation was largely behind the multilateral effort represented by the International Indian Ocean Expedition (IIEO), which was coordinated by the Scientific Committee for Ocean Research (SCOR), and which ran from 1959-1965. Work during this expedition focused on the Arabian Sea, the area to the northwest of Australia and the waters over the continental shelves and slopes of coastal states in the region. Subsequently several large-scale international oceanographic programmes have included significant components in the Indian Ocean, including the Joint Global Ocean Flux Study (JGOFS) and the World Ocean Circulation Experiment (WOCE). These studies were focused on physical oceanographic measurements and biogeochemistry and whilst the Indian Ocean is still less understood than other large oceans it is now integrated into the major ocean observation systems (Talley et al., 2011). This cannot be said for many aspects of the biology of the region, despite the fact that the Indian Ocean is one of the places where exploitation of marine living resources is still growing (FAO, 2016). The biology of the deep Indian Ocean outside of the Arabian Sea is particularly poorly understood given the presence of globally significant areas of seamounts, submarine plateaus, continental and island slopes.

Examining the effects of technology-infused issue investigations on high school students' environmental and ocean literacies

NASA Astrophysics Data System (ADS)

Plankis, Brian J.

The purpose of the study was to examine the effects of technology-infused issue investigations on high school students' environmental and ocean literacies. This study explored the effects of a new educational enrichment program termed Connecting the Ocean, Reefs, Aquariums, Literacy, and Stewardship (CORALS) on high school science students. The study utilized a mixed methods approach combining a quantitative quasi-experimental pre-post test design with qualitative case studies. The CORALS program is a new educational program that combines materials based on the Investigating and Evaluating Environmental Issues and Actions (IEEIA) curriculum program with the digital storytelling process. Over an 18-week period four high school science teachers and their approximately 169 students investigated environmental issues impacting coral reefs through the IEEIA framework. An additional approximately 224 students, taught by the same teachers, were the control group exposed to standard curriculum. Students' environmental literacy was measured through the Secondary School Environmental Literacy Instrument (SSELI) and students' ocean literacy was measured through the Students' Ocean Literacy Viewpoints and Engagement (SOLVE) instrument. Two classrooms were selected as case studies and examined through classroom observations and student and teacher interviews. The results indicated the CORALS program increased the knowledge of ecological principles, knowledge of environmental problems/issues, and environmental attitudes components of environmental literacy for the experimental group students. For ocean literacy, the experimental group students' scores increased for knowledge of ocean literacy principles, ability to identify oceanic environmental problems, and attitudes concerning the ocean. The SSELI measure of Responsible Environmental Behaviors (REB) was found to be significant for the interaction of teacher and class type (experimental or control). The students for Teachers A and B reported a statistically significant increase in the self-reported REB subscales of ecomanagement and consumer/economic action. This indicates the students reported an increase in the REBs they could change within their lifestyles. This study provides baseline data in an area where few quality studies exist to date. Recommendations for practice and administration of the research study instruments are explored. Recommendations for further research include CORALS program modifications, revising the instruments utilized, and what areas of students' environmental and ocean literacies warrant further exploration.

Studying ocean acidification in the Arctic Ocean

USGS Publications Warehouse

Robbins, Lisa

2012-01-01

The U.S. Geological Survey (USGS) partnership with the U.S. Coast Guard Ice Breaker Healey and its United Nations Convention Law of the Sea (UNCLOS) cruises has produced new synoptic data from samples collected in the Arctic Ocean and insights into the patterns and extent of ocean acidification. This framework of foundational geochemical information will help inform our understanding of potential risks to Arctic resources due to ocean acidification.

Ocean tides

NASA Technical Reports Server (NTRS)

Hendershott, M. C.

1975-01-01

A review of recent developments in the study of ocean tides and related phenomena is presented. Topics briefly discussed include: the mechanism by which tidal dissipation occurs; continental shelf, marginal sea, and baroclinic tides; estimation of the amount of energy stored in the tide; the distribution of energy over the ocean; the resonant frequencies and Q factors of oceanic normal modes; the relationship of earth tides and ocean tides; and numerical global tidal models.

The Importance of Planetary Rotation Period for Ocean Heat Transport

PubMed Central

Stevens, D.; Joshi, M.

2014-01-01

Abstract The climate and, hence, potential habitability of a planet crucially depends on how its atmospheric and ocean circulation transports heat from warmer to cooler regions. However, previous studies of planetary climate have concentrated on modeling the dynamics of atmospheres, while dramatically simplifying the treatment of oceans, which neglects or misrepresents the effect of the ocean in the total heat transport. Even the majority of studies with a dynamic ocean have used a simple so-called aquaplanet that has no continental barriers, which is a configuration that dramatically changes the ocean dynamics. Here, the significance of the response of poleward ocean heat transport to planetary rotation period is shown with a simple meridional barrier—the simplest representation of any continental configuration. The poleward ocean heat transport increases significantly as the planetary rotation period is increased. The peak heat transport more than doubles when the rotation period is increased by a factor of ten. There are also significant changes to ocean temperature at depth, with implications for the carbon cycle. There is strong agreement between the model results and a scale analysis of the governing equations. This result highlights the importance of both planetary rotation period and the ocean circulation when considering planetary habitability. Key Words: Exoplanet—Oceans—Rotation—Climate—Habitability. Astrobiology 14, 645–650. PMID:25041658

[Review of estimation on oceanic primary productivity by using remote sensing methods.

PubMed

Xu, Hong Yun; Zhou, Wei Feng; Ji, Shi Jian

2016-09-01

Accuracy estimation of oceanic primary productivity is of great significance in the assessment and management of fisheries resources, marine ecology systems, global change and other fields. The traditional measurement and estimation of oceanic primary productivity has to rely on in situ sample data by vessels. Satellite remote sensing has advantages of providing dynamic and eco-environmental parameters of ocean surface at large scale in real time. Thus, satellite remote sensing has increasingly become an important means for oceanic primary productivity estimation on large spatio-temporal scale. Combining with the development of ocean color sensors, the models to estimate the oceanic primary productivity by satellite remote sensing have been developed that could be mainly summarized as chlorophyll-based, carbon-based and phytoplankton absorption-based approach. The flexibility and complexity of the three kinds of models were presented in the paper. On this basis, the current research status for global estimation of oceanic primary productivity was analyzed and evaluated. In view of these, four research fields needed to be strengthened in further stu-dy: 1) Global oceanic primary productivity estimation should be segmented and studied, 2) to dee-pen the research on absorption coefficient of phytoplankton, 3) to enhance the technology of ocea-nic remote sensing, 4) to improve the in situ measurement of primary productivity.

How will ocean acidification affect Baltic sea ecosystems? an assessment of plausible impacts on key functional groups.

PubMed

Havenhand, Jonathan N

2012-09-01

Increasing partial pressure of atmospheric CO₂ is causing ocean pH to fall-a process known as 'ocean acidification'. Scenario modeling suggests that ocean acidification in the Baltic Sea may cause a ≤ 3 times increase in acidity (reduction of 0.2-0.4 pH units) by the year 2100. The responses of most Baltic Sea organisms to ocean acidification are poorly understood. Available data suggest that most species and ecologically important groups in the Baltic Sea food web (phytoplankton, zooplankton, macrozoobenthos, cod and sprat) will be robust to the expected changes in pH. These conclusions come from (mostly) single-species and single-factor studies. Determining the emergent effects of ocean acidification on the ecosystem from such studies is problematic, yet very few studies have used multiple stressors and/or multiple trophic levels. There is an urgent need for more data from Baltic Sea populations, particularly from environmentally diverse regions and from controlled mesocosm experiments. In the absence of such information it is difficult to envision the likely effects of future ocean acidification on Baltic Sea species and ecosystems.

Lipotoxicity Mediated Cell Dysfunction and Death Involves Lysosomal Membrane Permeabilization and Cathepsin L Activity

PubMed Central

Almaguel, Frankis G.; Liu, Jo-Wen; Pacheco, Fabio J.; De Leon, Daisy; Casiano, Carlos A.; De Leon, Marino

2010-01-01

Lipotoxicity, which is triggered when cells are exposed to elevated levels of free fatty acids, involves cell dysfunction and apoptosis and is emerging as an underlying factor contributing to various pathological conditions including disorders of the central nervous system and diabetes. We have shown that palmitic acid (PA)-induced lipotoxicity (PA-LTx) in nerve growth factor-differentiated PC12 (NGFDPC12) cells is linked to an augmented state of cellular oxidative stress (ASCOS) and apoptosis, and that these events are inhibited by docosahexanoic acid (DHA). The mechanisms of PA-LTx in nerve cells are not well understood, but our previous findings indicate that it involves ROS generation, mitochondrial membrane permeabilization (MMP), and caspase activation. The present study used nerve growth factor differentiated PC12 cells (NGFDPC12 cells) and found that lysosomal membrane permeabilization (LMP) is an early event during PA-induced lipotoxicity that precedes MMP and apoptosis. Cathepsin L, but not cathepsin B, is an important contributor in this process since its pharmacological inhibition significantly attenuated LMP, MMP, and apoptosis. In addition, co-treatment of NGFDPC12 cells undergoing lipotoxicity with DHA significantly reduced LMP, suggesting that DHA acts by antagonizing upstream signals leading to lysosomal dysfunction. These results suggest that LMP is a key early mediator of lipotoxicity, and underscore the value of interventions targeting upstream signals leading to LMP for the treatment of pathological conditions associated with lipotoxicity. PMID:20043885

Ocean, Land and Meteorology Studies Using Space-Based Lidar Measurements

NASA Technical Reports Server (NTRS)

Hu,Yongxiang

2009-01-01

CALIPSO's main mission objective is studying the climate impact of clouds and aerosols in the atmosphere. CALIPSO also collects information about other components of the Earth's ecosystem, such as oceans and land. This paper introduces the physics concepts and presents preliminary results for the valueadded CALIPSO Earth system science products. These include ocean surface wind speeds, column atmospheric optical depths, ocean subsurface backscatter, land surface elevations, atmospheric temperature profiles, and A-train data fusion products.

Advances in Understanding Decadal Climate Variability

NASA Technical Reports Server (NTRS)

Busalaacchi, Antonio J.

1998-01-01

Recently, a joint Brazil-France-U.S. program, known as PIRATA (Pilot Research moored Array in the Tropical Atlantic), was proposed to begin the deployment of moored measurement platforms in the tropical Atlantic in order to enhance the existing observational data base and subsequent understanding of the processes by which the ocean and atmosphere couple in key regions of the tropical Atlantic Ocean. Empirical studies have suggested that there are strong relationships between tropical Atlantic upper ocean variability, SST, ocean-atmosphere coupling and regional climate variability. During the early 1980's a coordinated set of surface wind, subsurface thermal structure, and subsurface current observations were obtained as part of the U.S.-France SEQUAL- FOCAL process experiment designed to observe the seasonal response of the tropical Atlantic Ocean to surface forcing. Since that time, however, the observational data base for the tropical Atlantic Ocean has disintegrated to a few shiptracks measuring ocean temperatures and a small collection of tide gauge stations measuring sea level. A more comprehensive set of observations, modeling and empirical studies is now in order to make progress on understanding the regional climate variability. The proposed PIRATA program will use mooring platforms similar to the tropical Pacific Ocean TAO array to measure surface fluxes of momentum and heat and the corresponding changes in the upper ocean thermal structure. It is anticipated that the oceanic data from this monitoring array will also be used in a predictive mode for initialization studies of regional coupled climate models. Of particular interest are zonal and meridional modes of ocean-atmosphere variability within the tropical Atlantic basin that have significant impacts on the regional climate of the bordering continents.

Southern Ocean vertical iron fluxes; the ocean model effect

NASA Astrophysics Data System (ADS)

Schourup-Kristensen, V.; Haucke, J.; Losch, M. J.; Wolf-Gladrow, D.; Voelker, C. D.

2016-02-01

The Southern Ocean plays a key role in the climate system, but commonly used large-scale ocean general circulation biogeochemical models give different estimates of current and future Southern Ocean net primary and export production. The representation of the Southern Ocean iron sources plays an important role for the modeled biogeochemistry. Studies of the iron supply to the surface mixed layer have traditionally focused on the aeolian and sediment contributions, but recent work has highlighted the importance of the vertical supply from below. We have performed a model study in which the biogeochemical model REcoM2 was coupled to two different ocean models, the Finite Element Sea-ice Ocean Model (FESOM) and the MIT general circulation model (MITgcm) and analyzed the magnitude of the iron sources to the surface mixed layer from below in the two models. Our results revealed a remarkable difference in terms of mechanism and magnitude of transport. The mean iron supply from below in the Southern Ocean was on average four times higher in MITgcm than in FESOM and the dominant pathway was entrainment in MITgcm, whereas diffusion dominated in FESOM. Differences in the depth and seasonal amplitude of the mixed layer between the models affect on the vertical iron profile, the relative position of the base of the mixed layer and ferricline and thereby also on the iron fluxes. These differences contribute to differences in the phytoplankton composition in the two models, as well as in the timing of the onset of the spring bloom. The study shows that the choice of ocean model has a significant impact on the iron supply to the Southern Ocean mixed layer and thus on the modeled carbon cycle, with possible implications for model runs predicting the future carbon uptake in the region.

Advances in Understanding Decadal Climate Variability

NASA Technical Reports Server (NTRS)

Busalacchi, Antonio J.

1999-01-01

Recently, a joint Brazil-France-U.S. program, known as PIRATA (Pilot Research moored Array in the Tropical Atlantic), was proposed to begin the deployment of moored measurement platforms in the tropical Atlantic in order to enhance the existing observational data base and subsequent understanding of the processes by which the ocean and atmosphere couple in key regions of the tropical Atlantic Ocean. Empirical studies have suggested that there are strong relationships between tropical Atlantic upper ocean variability, SST, ocean-atmosphere coupling and regional climate variability. During the early 1980's a coordinated set of surface wind, subsurface thermal structure, and subsurface current observations were obtained as part of the U.S.-France SEQUAL-FOCAL process experiment designed to observe the seasonal response of the tropical Atlantic Ocean to surface forcing. Since that time, however, the observational data base for the tropical Atlantic Ocean has disintegrated to a few ship-tracks measuring ocean temperatures and a small collection of tide gauge stations measuring sea level. A more comprehensive set of observations, modeling and empirical studies is now in order to make progress on understanding the regional climate variability. The proposed PIRATA program will use mooring platforms similar to the tropical Pacific Ocean TAO array to measure surface fluxes of momentum and heat and the corresponding changes in the upper ocean thermal structure. It is anticipated that the oceanic data from this monitoring array will also be used in a predictive mode for initialization studies of regional coupled climate models. Of particular interest are zonal and meridional modes of ocean-atmosphere variability within the tropical Atlantic basin that have significant impacts on the regional climate of the bordering continents.

Slow and Steady: Ocean Circulation. The Influence of Sea Surface Height on Ocean Currents

NASA Technical Reports Server (NTRS)

Haekkinen, Sirpa

2000-01-01

The study of ocean circulation is vital to understanding how our climate works. The movement of the ocean is closely linked to the progression of atmospheric motion. Winds close to sea level add momentum to ocean surface currents. At the same time, heat that is stored and transported by the ocean warms the atmosphere above and alters air pressure distribution. Therefore, any attempt to model climate variation accurately must include reliable calculations of ocean circulation. Unlike movement of the atmosphere, movement of the ocean's waters takes place mostly near the surface. The major patterns of surface circulation form gigantic circular cells known as gyres. They are categorized according to their general location-equatorial, subtropical, subpolar, and polar-and may run across an entire ocean. The smaller-scale cell of ocean circulation is known' as an eddy. Eddies are much more common than gyres and much more difficult to track in computer simulations of ocean currents.

Impetus and barriers to teaching ocean literacy: A perspective from landlocked middle school science teachers

NASA Astrophysics Data System (ADS)

Gillan, Amy Larrison

The demand for a more ocean literate citizenry is growing rapidly in response to an ocean increasingly in peril. Discovering how to include students far removed from the ocean in our teaching about the ocean is imperative to meeting that charge. The purpose of the present study was to investigate the extent to which middle school science teachers in landlocked states addressed important ocean literacy concepts and what they perceived to be barriers and motivators to their doing so. This descriptive study was based on a nation-wide survey of middle school science teachers and content analyses of their most commonly used science textbooks and their state science standards. Data was analyzed quantitatively. Results indicated that landlocked and coastal teachers are similar in terms of their infrequency of teaching about the ocean, yet a number of their perceptions of barriers and motivators to do so vary. The barrier most often mentioned was middle school state science standards, which characteristically ignore the ocean sciences. The results are discussed in terms of their impact on ocean literacy professional development providers, science textbook publishers, and state science standards revision committees.

Application of Satellite Altimetry to Ocean Circulation Studies: 1987-1994

NASA Technical Reports Server (NTRS)

Fu, L. -L.; Cheney, R. E.

1994-01-01

Altimetric measurement of the height of the sea surface from space provides global observation of the world's oceans. The last eight years have witnessed a rapid growth in the use of altimetry data from the study of the ocean circulations, thanks to the multiyear data from the Geosat Mission.

Dynamic relationship between ocean bottom pressure and bathymetry around northern part of Hikurangi

NASA Astrophysics Data System (ADS)

Muramoto, T.; Inazu, D.; Ito, Y.; Hino, R.; Suzuki, S.

2017-12-01

In recent years, observation using ocean bottom pressure recorders for the purpose of the evaluation of sea floor crustal deformation is in great vogue. The observation network set up for the observation of sea floor is densely spaced compared with the instrument network for the observation of ocean. Therefore, it has the characteristic that it can observe phenomena on a local scale. In this study, by using these in situ data, we discuss ocean phenomena on a local scale. In this study, we use a high-resolution ocean model (Inazu Ocean Model) driven by surface air pressure and surface wind vector published by the Japan Meteorological Agency. We perform a hindcast experiment for ocean bottom pressure anomaly from April 2013 to June 2017. Then, we compare these results with in situ data. In this study, we use observed pressure records which were recorded by autonomous type instrument spanning a period from April 2013 to June 2017 off the coast of North Island in New Zealand. Consequently, we found this model can simulate not only the amplitude but also phase of non-tidal oceanic variation of East Cape Current (ECC) off the coast of North Island of New Zealand. Then, we calculate cross-correlation coefficient between the data at the OBP sites. We revealed that the ocean bottom pressure shows different behavior on the west side from the east side of edge of the continental shelf. This result implies that the submarine slope induces a dynamic effect and contributes to the seasonal variation of ocean bottom pressure. In addition, we calculate the velocity of the surface current in this area using our model, and consider the relationship between it and ocean bottom pressure variation. Taken together, we can say that the barotropic flow in the direction of south-west extends to the bottom of the sea in this area. Therefore, the existence of local cross-isobath currents is suggested. Our result indicates bathymetry has dynamic effect to ocean circulation on local scale and at the same time the surface ocean circulation contributes to ocean bottom pressure considerably.

Skipjack tuna as a bioindicator of contamination by perfluorinated compounds in the oceans.

PubMed

Hart, Kimberly; Kannan, Kurunthachalam; Tao, Lin; Takahashi, Shin; Tanabe, Shinsuke

2008-09-15

Perfluorinated chemicals (PFCs) have emerged as global environmental contaminants. Studies have reported the widespread occurrence of PFCs in biota from marine coastal waters and in remote polar regions. However, few studies have reported the distribution of PFCs in biota from offshore waters and open oceans. In this study, concentrations of nine PFCs were determined in the livers of 60 skipjack tuna (Katsuwonus pelamis) collected from offshore waters and the open ocean along the Pacific Rim, including the Sea of Japan, the East China Sea, the Indian Ocean, and the Western North Pacific Ocean, during 1997-1999. At least one of the nine PFCs was found in every tuna sample analyzed. Overall, perfluorooctanesulfonate (PFOS) and perfluoroundecanoic acid (PFUnDA) were the predominant compounds found in livers of tuna at concentrations of <1-58.9 and <1-31.6 ng/g, wet wt, respectively. Long-chain perfluorocarboxylates such as perfluorodecanoic acid (PFDA) and perfluorododecanoic acid (PFDoDA) were common in the tuna livers. In livers of tuna from several offshore and open-ocean locations, concentrations of PFUnDA were greater than the concentrations of PFOS. The profiles and concentrations of PFCs in tuna livers suggest that the sources in East Asia are dominated by long-chain perfluorocarboxylates, especially PFUnDA. High concentrations of PFUnDA in tuna may indicate a shift in sources of PFCs in East Asia. The spatial distribution of PFOS in skipjack tuna reflected the concentrations previously reported in seawater samples from the Pacific and Indian Oceans, suggesting that tuna are good bioindicators of pollution by PFOS. Despite its predominance in ocean waters, PFOA was rarely found in tuna livers, indicative of the low bioaccumulation potential of this compound. Our study establishes baseline concentrations of PFCs in skipjack tuna from the oceans of the Asia-Pacific region, enabling future temporal trend studies of PFCs in oceans.

Institutional Change through Assessment: Contrasting Case Studies

ERIC Educational Resources Information Center

Deess, E. Pierre; Elliot, Norbert

2009-01-01

The framework for understanding the management difference is neatly captured by the "red ocean" and "blue ocean" strategies described by W. Chan Kim and Renee Mauborgne in "Blue Ocean Strategy" (Kim & Mauborgne, 2004). In the original, the terms refer to alternative market strategies. Red ocean means competition in a market defined by a zero sum…

Remotely sensed and laboratory spectral signatures of an ocean-dumped acid waste

NASA Technical Reports Server (NTRS)

Lewis, B. W.; Collins, V. G.

1977-01-01

An ocean-dumped acid waste plume was studied by using a rapid scanning spectrometer to remotely measure ocean radiance from a helicopter. The results of these studies are presented and compared with results from sea truth samples and laboratory experiments. An ocean spectral reflectance signature and a laboratory spectral transmission signature were established for the iron-acid waste pollutant. The spectrally and chemically significant component of the acid waste pollutant was determined to be ferric iron.

Impact of atmospheric and terrestrial CO2 feedbacks on fertilization-induced marine carbon uptake

NASA Astrophysics Data System (ADS)

Oschlies, A.

2009-04-01

The sensitivity of oceanic CO2 uptake to alterations in the marine biological carbon pump, such as brought about by natural or purposeful ocean fertilization, has repeatedly been investigated by studies employing numerical biogeochemical ocean models. It is shown here that the results of such ocean-centered studies are very sensitive to the assumption made about the response of the carbon reservoirs on the atmospheric side of the sea surface. Assumptions made include prescribed atmospheric pCO2, an interactive atmospheric CO2 pool exchanging carbon with the ocean but not with the terrestrial biosphere, and an interactive atmosphere that exchanges carbon with both oceanic and terrestrial carbon pools. The impact of these assumptions on simulated annual to millennial oceanic carbon uptake is investigated for a hypothetical increase in the C:N ratio of the biological pump and for an idealized enhancement of phytoplankton growth. Compared to simulations with interactive atmosphere, using prescribed atmospheric pCO2 overestimates the sensitivity of the oceanic CO2 uptake to changes in the biological pump, by about 2%, 25%, 100%, and >500% on annual, decadal, centennial, and millennial timescales, respectively. Adding an interactive terrestrial carbon pool to the atmosphere-ocean model system has a small effect on annual timescales, but increases the simulated fertilization-induced oceanic carbon uptake by about 4%, 50%, and 100% on decadal, centennial, and millennial timescales, respectively. On longer than decadal timescales, a substantial fraction of oceanic carbon uptake induced by natural or purposeful ocean fertilization may not come from the atmosphere but from the terrestrial biosphere.

Oceanic sources of predictability for MJO propagation across the Maritime Continent in a subset of S2S forecast models

NASA Astrophysics Data System (ADS)

DeMott, C. A.; Klingaman, N. P.

2017-12-01

Skillful prediction of the Madden-Julian oscillation (MJO) passage across the Maritime Continent (MC) has important implications for global forecasts of high-impact weather events, such as atmospheric rivers and heat waves. The North American teleconnection response to the MJO is strongest when MJO convection is located in the western Pacific Ocean, but many climate and forecast models are deficient in their simulation of MC-crossing MJO events. Compared to atmosphere-only general circulation models (AGCMs), MJO simulation skill generally improves with the addition of ocean feedbacks in coupled GCMs (CGCMs). Using observations, previous studies have noted that the degree of ocean coupling may vary considerably from one MJO event to the next. The coupling mechanisms may be linked to the presence of ocean Equatorial Rossby waves, the sign and amplitude of Equatorial surface currents, and the upper ocean temperature and salinity profiles. In this study, we assess the role of ocean feedbacks to MJO prediction skill using a subset of CGCMs participating in the Subseasonal-to-Seasonal (S2S) Project database. Oceanic observational and reanalysis datasets are used to characterize the upper ocean background state for observed MJO events that do and do not propagate beyond the MC. The ability of forecast models to capture the oceanic influence on the MJO is first assessed by quantifying SST forecast skill. Next, a set of previously developed air-sea interaction diagnostics is applied to model output to measure the role of SST perturbations on the forecast MJO. The "SST effect" in forecast MJO events is compared to that obtained from reanalysis data. Leveraging all ensemble members of a given forecast helps disentangle oceanic model biases from atmospheric model biases, both of which can influence the expression of ocean feedbacks in coupled forecast systems. Results of this study will help identify areas of needed model improvement for improved MJO forecasts.

NOAA's Ocean Acidification Program - Funding Studies of Species' Responses to Ocean Acidification Since 2012

NASA Astrophysics Data System (ADS)

Ombres, E. H.

2016-02-01

NOAA's Ocean Acidification Program (OAP) was created as a mandate of the 2009 Federal Ocean Acidification Research and Monitoring (FOARAM) Act and has been directly funding species response research since 2012. Although OA species response is a relatively young field of science, this program built on research already underway across NOAA. That research platform included experimental facilities in the Fishery Sciences Centers of the National Marine Fishery Service (NMFS), `wet' labs of Oceanic and Atmospheric Research (OAR), and the coral reef monitoring studies within the National Ocean Service (NOS). The diversity of research across NOAA allows the program to make interdisciplinary connections among chemists, biologists and oceanographers and creates a more comprehensive and robust approach to understanding species response to this change in the carbon cycle. To date, the program has studied a range of taxa including phytoplankton, molluscs, crustaceans, and fish. This poster describes representative results from the collection of OAP-funded species at nationwide NOAA facilities.

Impact of a Cosmic Body into Earth's Ocean and the Generation of Large Tsunami Waves: Insight from Numerical Modeling

NASA Astrophysics Data System (ADS)

Wünnemann, K.; Collins, G. S.; Weiss, R.

2010-12-01

The strike of a cosmic body into a marine environment differs in several respects from impact on land. Oceans cover approximately 70% of the Earth's surface, implying not only that oceanic impact is a very likely scenario for future impacts but also that most impacts in Earth's history must have happened in marine environments. Therefore, the study of oceanic impact is imperative in two respects: (1) to quantify the hazard posed by future oceanic impacts, including the potential threat of large impact-generated tsunami-like waves, and (2) to reconstruct Earth's impact record by accounting for the large number of potentially undiscovered crater structures in the ocean crust. Reconstruction of the impact record is of crucial importance both for assessing the frequency of collision events in the past and for better predicting the probability of future impact. We summarize the advances in the study of oceanic impact over the last decades and focus in particular on how numerical models have improved our understanding of cratering in the oceanic environment and the generation of waves by impact. We focus on insight gleaned from numerical modeling studies into the deceleration of the projectile by the water, cratering of the ocean floor, the late stage modification of the crater due to gravitational collapse, and water resurge. Furthermore, we discuss the generation and propagation of large tsunami-like waves as a result of a strike of a cosmic body in marine environments.

Eddies in the Southern Ocean

NASA Image and Video Library

2015-04-08

The cloud cover over the Southern Ocean occasionally parts as it did on January 1, 2015 just west of the Drake Passage where the VIIRS instrument on the Suomi NPP satellite glimpsed the above collection of ocean-color delineated eddies which have diameters ranging from a couple of kilometers to a couple of hundred kilometers. Recent studies indicate that eddy activity has been increasing in the Southern Ocean with possible implications for climate change. Credit: NASA's OceanColor/Suomi NPP/VIIRS

Ocean Optics Protocols for Satellite Ocean Color Sensor Validation. Volume 6; Special Topics in Ocean Optics Protocols and Appendices; Revised

NASA Technical Reports Server (NTRS)

Mueller, J. L. (Editor); Fargion, Giulietta S. (Editor); McClain, Charles R. (Editor)

2003-01-01

This document stipulates protocols for measuring bio-optical and radiometric data for the Sensor Intercomparison and Merger for Biological and Interdisciplinary Oceanic Studies (SIMBIOS) Project activities and algorithm development. The document is organized into 6 separate volumes as Ocean Optics Protocols for Satellite Ocean Color Sensor Validation, Revision 4. Volume I: Introduction, Background and Conventions; Volume II: Instrument Specifications, Characterization and Calibration; Volume III: Radiometric Measurements and Data Analysis Methods; Volume IV: Inherent Optical Properties: Instruments, Characterization, Field Measurements and Data Analysis Protocols; Volume V: Biogeochemical and Bio-Optical Measurements and Data Analysis Methods; Volume VI: Special Topics in Ocean Optics Protocols and Appendices. The earlier version of Ocean Optics Protocols for Satellite Ocean Color Sensor Validation, Revision 3 (Mueller and Fargion 2002, Volumes 1 and 2) is entirely superseded by the six volumes of Revision 4 listed above.

Design and implementation of a 3D ocean virtual reality and visualization engine

NASA Astrophysics Data System (ADS)

Chen, Ge; Li, Bo; Tian, Fenglin; Ji, Pengbo; Li, Wenqing

2012-12-01

In this study, a 3D virtual reality and visualization engine for rendering the ocean, named VV-Ocean, is designed for marine applications. The design goals of VV-Ocean aim at high fidelity simulation of ocean environment, visualization of massive and multidimensional marine data, and imitation of marine lives. VV-Ocean is composed of five modules, i.e. memory management module, resources management module, scene management module, rendering process management module and interaction management module. There are three core functions in VV-Ocean: reconstructing vivid virtual ocean scenes, visualizing real data dynamically in real time, imitating and simulating marine lives intuitively. Based on VV-Ocean, we establish a sea-land integration platform which can reproduce drifting and diffusion processes of oil spilling from sea bottom to surface. Environment factors such as ocean current and wind field have been considered in this simulation. On this platform oil spilling process can be abstracted as movements of abundant oil particles. The result shows that oil particles blend with water well and the platform meets the requirement for real-time and interactive rendering. VV-Ocean can be widely used in ocean applications such as demonstrating marine operations, facilitating maritime communications, developing ocean games, reducing marine hazards, forecasting the weather over oceans, serving marine tourism, and so on. Finally, further technological improvements of VV-Ocean are discussed.

Simultaneous LC-MS-MS determination of cyclosporine A, tacrolimus, and sirolimus in whole blood as well as mycophenolic acid in plasma using common pretreatment procedure.

PubMed

Bogusz, Maciej J; Enazi, Eid Al; Hassan, Huda; Abdel-Jawaad, Jamil; Ruwaily, Jamal Al; Tufail, Mohammed Al

2007-05-01

The purpose of the study was to develop rapid and simple procedure for simultaneous determination of cyclosporine A (CsA), tacrolimus (TCR), and sirolimus (SIR) in whole blood and mycophenolic acid (MPA) in plasma. Ascomycin (ASCO), cyclosporine D (CsD), and desmethoxysirolimus (DMSIR) were used as internal standards (IS) for TCR, CsA and MPA, and SIR, respectively. In the method development, six-level blood calibrators were used for CsA (range 47-1725 ng/ml), TCR (range 2.1-38.8 ng/ml), and SIR (range 2.4-39.6 ng/ml). Four-level calibrators were used for MPA (range 0.15-5.48 microg/ml). Four levels of quality control (QC) standards were used for blood samples, together with two levels of QC standards in plasma. All QC standards and calibrators were obtained from commercial sources. Sample preparation based on precipitation of 50 microl of sample in zinc sulfate-methanol-acetonitrile mixture containing IS, followed by centrifugation. HPLC was performed on ChromSpher pi column, 30 mm x 3 mm, in ballistic gradient of ammonium formate buffer-methanol at 0.8 ml flow rate. Following gradient elution profile was applied: 0-1.2 min at 30% methanol (divert valve to waste), 1.21-3.1 min 97% methanol (divert valve to detector), 3.11-3.7 min 30% methanol (divert valve to waste). ESI-MS-MS (MRM) was done on TSQ Quantum instrument with ESI source in positive ion mode. Ammoniated adducts of protonated molecules were used as precursor ions for all analytes but MPA. For this compound sodium adduct was used. Following transitions were monitored: for CsA m/z 1220-1203; for CsD 1234-1217; for SIR 931.6-864.5 and 882.6; for DMSIR 902-834.5; for TCR 821.5-768.5 and 785.5; for ASCO 809.5-756; for MPA 343-211.6; for MPA-glucuronide 514-306 and 211.6. The limits of quantitation were: 1 ng/ml for TCR and SIR, 20 ng/ml for CsA, and 0.1 microg/ml for MPA. Post-column infusion experiments showed that no positive or negative peaks appeared after injection of matrix in the elution range of target compounds. General signal suppression caused by matrix ranged from 20-40%, and was caused mainly by zinc sulfate present in deproteinizing solution. Extracted samples were stable for 2 days at 4 degrees C and for at least 20 days at -20 degrees C. MPA was fully separated from its glucuronide, which was eluted at around 0.7-0.8 min and directed to the waste. Some mutual cross-contribution of CsD and CsA was observed (below 1%), other IS did not contribute to target compounds and vice versa. Observations of chromatograms from patients taken single therapy demonstrated that possible metabolites of CsA, TCR, or SIR did not interfere with target compounds or IS.

Clinical Cancer Advances 2013: Annual Report on Progress Against Cancer from the American Society of Clinical Oncology.

PubMed

Patel, Jyoti D; Krilov, Lada; Adams, Sylvia; Aghajanian, Carol; Basch, Ethan; Brose, Marcia S; Carroll, William L; de Lima, Marcos; Gilbert, Mark R; Kris, Mark G; Marshall, John L; Masters, Gregory A; O'Day, Steven J; Polite, Blasé; Schwartz, Gary K; Sharma, Sunil; Thompson, Ian; Vogelzang, Nicholas J; Roth, Bruce J

2014-01-10

Since its founding in 1964, the American Society of Clinical Oncology (ASCO) has been committed to improving cancer outcomes through research and the delivery of quality care. Research is the bedrock of discovering better treatments--providing hope to the millions of individuals who face a cancer diagnosis each year. The studies featured in "Clinical Cancer Advances 2013: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology" represent the invaluable contributions of thousands of patients who participate in clinical trials and the scientists who conduct basic and clinical research. The insights described in this report, such as how cancers hide from the immune system and why cancers may become resistant to targeted drugs, enable us to envision a future in which cancer will be even more controllable and preventable. The scientific process is thoughtful, deliberate, and sometimes slow, but each advance, while helping patients, now also points toward new research questions and unexplored opportunities. Both dramatic and subtle breakthroughs occur so that progress against cancer typically builds over many years. Success requires vision, persistence, and a long-term commitment to supporting cancer research and training. Our nation's longstanding investment in federally funded cancer research has contributed significantly to a growing array of effective new treatments and a much deeper understanding of the drivers of cancer. But despite this progress, our position as a world leader in advancing medical knowledge and our ability to attract the most promising and talented investigators are now threatened by an acute problem: Federal funding for cancer research has steadily eroded over the past decade, and only 15% of the ever-shrinking budget is actually spent on clinical trials. This dismal reality threatens the pace of progress against cancer and undermines our ability to address the continuing needs of our patients. Despite this extremely challenging economic environment, we continue to make progress. Maintaining and accelerating that progress require that we keep our eyes on the future and pursue a path that builds on the stunning successes of the past. We must continue to show our policymakers the successes in cancer survival and quality of life (QOL) they have enabled, emphasizing the need to sustain our national investment in the remarkably productive US cancer research enterprise. We must also look to innovative methods for transforming how we care for-and learn from-patients with cancer. Consider, for example, that fewer than 5% of adult patients with cancer currently participate in clinical trials. What if we were able to draw lessons from the other 95%? This possibility led ASCO this year to launch CancerLinQ, a groundbreaking health information technology initiative that will provide physicians with access to vast quantities of clinical data about real-world patients and help achieve higher quality, higher value cancer care. As you read the following pages, I hope our collective progress against cancer over the past year inspires you. More importantly, I hope the pride you feel motivates you to help us accelerate the pace of scientific advancement. Clifford A. Hudis, MD, FACP President American Society of Clinical Oncology.

The Market as an Institution for Zoning the Ocean

NASA Astrophysics Data System (ADS)

Clinton, J. E.; Hoagland, P.

2008-12-01

In recent years, spatial conflicts among ocean users have increased significantly, particularly in the coastal ocean. Ocean zoning has been proposed as a promising solution to these conflicts. Strikingly, most ocean zoning proponents focus on a centralized approach, involving government oversight, planning, and spatial allocations. We hypothesize that a market may be more efficient for allocating ocean space, because it tends to put ocean space in the hands of the highest valued uses, and it does not require public decision-makers to compile and analyze large amounts of information. Importantly, where external costs arise, a market in ocean space may need government oversight or regulation. We develop four case studies demonstrating that private allocations of ocean space are taking place already. This evidence suggests that a regulated market in ocean space may perform well as an allocative institution. We find that the proper functioning of a market in ocean space depends positively upon the strength of legal property rights and supportive public policies and negatively upon the number of users and the size of transaction costs.

Buffered versus non-buffered ocean carbon reservoir variations: Application to the sensitivity of atmospheric pCO2 to ocean circulation changes

NASA Astrophysics Data System (ADS)

d'Orgeville, M.; England, M. H.; Sijp, W. P.

2011-12-01

Changes in the ocean circulation on millenial timescales can impact the atmospheric CO2 concentration by two distinct mechanisms: either by modifying the non-buffered ocean carbon storage (through changes in the physical and biological oceanic pumps) or by directly varying the surface mean oceanic partial pressure of pCO2 (through changes in mean surface alkalinity, temperature or salinity). The equal importance of the two mechanisms is illustrated here by introducing a diagnostic buffered carbon budget on the results of simulations performed with an Earth System Climate Model. For all the circulation changes considered in this study (due to a freshening of the North Atlantic, or a change in the Southern Hemisphere Westerly winds), the sign of the atmospheric CO2 response is opposite to the sign of the non-buffered ocean carbon storage change, indicating a transfer of carbon between ocean and atmosphere reservoirs. However the concomitant changes in the buffered ocean carbon reservoir can either greatly enhance or almost inhibit the atmospheric response depending on its sign. This study also demonstrates the utility of the buffered carbon budget approach in diagnosing the transient response of the global carbon cycle to climatic variations.

The National Ocean Sciences Bowl: An Effective Model for Engaging High School Students in Ocean Science

NASA Astrophysics Data System (ADS)

Holloway, A. E.

2016-02-01

The National Ocean Sciences Bowl (NOSB) is an informal high school education program that engages students in ocean and environmental science and exposes them to the breadth of ocean-related careers. The NOSB strives to train the next generation of interdisciplinary capable scientists and build a STEM-literate society that harnesses the power of ocean and climate science to address environmental, economic, and societal issues. Through the NOSB, students not only learn scientific principles, but also apply them to compelling real-world problems. The NOSB provides a richer STEM education and exposes students to ocean science topics they may not otherwise study through classroom curriculum. A longitudinal study that began in 2007 has shown that NOSB participants have an enhanced interest in ocean-related hobbies and environmental stewardship and an increasing number of these students have remained in the STEM pipeline and workforce.While the NOSB is primarily an academic competition, it has evolved since its creation in 1998 to include a variety of practical and professional development components. One of the program enhancements, the Scientific Expert Briefing (SEB), gives students the opportunity to apply what they have studied and think critically about current and ongoing ocean science challenges. The SEB helps students connect their knowledge of ocean science with current and proposed policy initiatives. Students gain significant research, writing, and presentation skills, while enhancing their ability for collaboration and consensus building, all vital workforce skills. Ultimately, the SEB teaches students how to communicate complex scientific research into digestible information for decision-makers and the general public.This poster will examine the impact of the NOSB and its role in strengthening the workforce pipeline through a combination of independent learning, competition, and opportunities for communication skills development.

Determination of Acoustic Effects on Marine Mammals and Sea Turtles for the Hawaii-Southern California Training and Testing Environmental Impact Statement/Overseas Environmental Impact Statement

DTIC Science & Technology

2012-03-12

Acoustic Simulation System/Gaussian Ray Bundle (CASS/GRAB), Range-Dependent Acoustic Model (RAM), or Reflection and Refraction Multilayered Ocean / Ocean ...Multilayered Ocean / Ocean Bottoms with Shear Wave Effects RES Relative Environmental Suitability SEL Sound exposure level SOCAL Southern California SPL...the Office of Naval Research. The HSTT Study Area is comprised of established operating and warning areas across the north-central Pacific Ocean

Air-Sea Enthalpy and Momentum Exchange at Major Hurricane Wind Speeds Observed during CBLAST

DTIC Science & Technology

2012-11-01

Oceanic and Atmospheric Administration, and ONR for organizing the CBLAST experiment and collecting the data used for this study. Thanks also go to...Atmos. Oceanic Technol., 21, 457–469. Gill, A., 1982: Atmosphere – Ocean Dynamics. Academic Press, 662 pp. Haus, B. K., D. Jeong,M.A.Donelan, J. A...Open ocean momentum flux measurements in moderate to strong winds. J. Phys. Ocean - ogr., 11, 324–336. Lindzen, R., 1990: Dynamics in Atmospheric

Ocean images in music compositions and folksongs

NASA Astrophysics Data System (ADS)

Liu, C. M.

2017-12-01

In general, ocean study usually ranges from physical oceanography, chemical oceanography, marine biology, marine geology, and other related fields. In addition to pure scientific fields, ocean phenomenon influence not only human mood but also the shaping of local cultures. In this paper, we present some ocean images and concepts appeared in music compositions and folksongs to show the mixing, influence and interaction between them. This may give a novel way not for science teachers but also music teachers to deliver the knowledge of ocean science in classes.

The role stratification on Indian ocean mixing under global warming

NASA Astrophysics Data System (ADS)

Praveen, V.; Valsala, V.; Ravindran, A. M.

2017-12-01

The impact of changes in Indian ocean stratification on mixing under global warming is examined. Previous studies on global warming and associated weakening of winds reported to increase the stratification of the world ocean leading to a reduction in mixing, increased acidity, reduced oxygen and there by a reduction in productivity. However this processes is not uniform and are also modulated by changes in wind pattern of the future. Our study evaluate the role of stratification and surface fluxes on mixing focusing northern Indian ocean. A dynamical downscaling study using Regional ocean Modelling system (ROMS) forced with stratification and surface fluxes from selected CMIP5 models are presented. Results from an extensive set of historical and Representative Concentration Pathways 8.5 (rcp8.5) scenario simulations are used to quantify the distinctive role of stratification on mixing.

Satellite Sea-surface Salinity Retrieval Dependencies

NASA Astrophysics Data System (ADS)

Bayler, E. J.; Ren, L.

2016-02-01

Comparing satellite sea-surface salinity (SSS) measurements and in situ observations reveals large-scale differences. What causes these differences? In this study, five boxes, sampling various oceanic regimes of the global ocean, provide insights on the relative performance of satellite SSS retrievals with respect to the influences of SST, precipitation and wind speed. The regions sampled are: the Inter-tropical Convergence Zone (ITCZ), the South Pacific Convergence Zone (SPCZ), NASA's Salinity Processes of the Upper-ocean Regional Study (SPURS) area, the North Pacific subarctic region, and the southern Indian Ocean. This study examines satellite SSS data from NASA's Aquarius Mission and ESA's Soil Moisture - Ocean Salinity (SMOS) mission, specifically: Aquarius official Aquarius Data Processing System (ADPS) Level-2 data, experimental Aquarius Combined Active-Passive (CAP) Level-2 SSS data developed by NASA's Jet Propulsion Laboratory (JPL), and SMOS Level-2 data.

Seismic velocity structure of the incoming Pacific Plate subducting into the central part of the Japan Trench revealed by traveltime tomography using OBS data

NASA Astrophysics Data System (ADS)

Obana, K.; Fujie, G.; Kodaira, S.; Takahashi, T.; Yamamoto, Y.; Miura, S.; Shinohara, M.

2016-12-01

Subduction of oceanic plates plays an important role in the water transportation from the earth surface into the deep mantle. Recent active seismic survey studies succeed to image that the seismic velocities within the oceanic crust and the uppermost mantle in the outer rise region decreases toward the trench axis. These velocity changes are considered as an indication of the hydration and alteration of the incoming oceanic plates prior to the subduction. However, the area with sufficient resolution of the active seismic studies is often limited at depths corresponding to the oceanic crust and several km beneath the oceanic Moho. In this study, we have examined the seismic velocity structure of the incoming/subducting Pacific Plate beneath the trench axis and outer trench-slope of the central part of the Japan Trench. The seismicity in the Pacific Plate, including several M7-class intra-plate earthquakes, has been active since the 2011 Tohoku-Oki earthquake in the study area. These activities were observed by the ocean bottom seismographs (OBS) deployed repeatedly. The data obtained from these OBS observations allow us to resolve the seismic velocity structures at greater depths compared to the active seismic surveys. We conducted 3-D traveltime tomography by using double-difference tomography method (Zhang and Thurber, 2003). The results show that the seismic velocities within the oceanic mantle decreased toward the trench axis. The velocity reduction begins at about 80 km seaward of the trench axis and extended to a depth of at least 30 km beneath the trench axis area. If the observed P-wave velocity reduction from 8.4 km/s to 7.7 km/s at a depth of 15 km below the oceanic Moho is caused by the serpentinization of the oceanic mantle (Carlson and Miller, 2003), roughly 2.5 weight per cent of water is expected in the low velocity anomalies in the oceanic mantle.

Measuring Ocean Surface Waves using Signal Reflections from Geostationary Satellites

NASA Astrophysics Data System (ADS)

Ouellette, J. D.; Dowgiallo, D. J.; Hwang, P. A.; Toporkov, J. V.

2017-12-01

The delay-Doppler response of communications signals (such as GNSS) reflected off the ocean surface is well-known to have properties which strongly correlate with surface wind conditions and ocean surface roughness. This study extends reflectometry techniques currently applied to the GNSS constellation to include geostationary communications satellites such as XM Radio. In this study, ocean wind conditions and significant wave height will be characterized using the delay-Doppler response of XM Radio signals reflected off of ocean surface waves. Using geostationary satellites for reflectometry-based remote sensing of oceans presents two primary advantages. First, longer coherent integration times can be achieved, which boosts signal processing gain and allows for finer Doppler resolution. Second, being designed for wide-area broadcast communications, the ground-received power of these geostationary satellite signals tends to be many orders of magnitude stronger than e.g. GNSS signals. Reflections of such signals from the ocean are strong enough to be received well outside of the specular region. This flexibility of viewing geometry allows signal processing to be performed on data received from multiple incidence/reception angles, which can provide a more complete characterization of ocean surface roughness and surface wind vectors. This work will include studies of simulated and measured delay-Doppler behavior of XM Radio signals reflected from dynamic ocean surfaces. Simulation studies will include inter-comparison between a number of hydrodynamic and electromagnetic models. Results from simulations will be presented as delay-Doppler plots and will be compared with delay-Doppler behavior observed in measured data. Measured data will include field campaign results from early- to mid-2017 in which the US Naval Research Laboratory's in-house XM reflectometer-receiver was deployed near the coasts of Virginia and North Carolina to observe reflections from wind-driven ocean waves. Preliminary results from a significant wave height retrieval algorithm will also be presented.

An Overview of Ocean Lidar Studies At NRL Stennis, NOAA ESRL and NASA LaRC (Invited)

NASA Astrophysics Data System (ADS)

Hu, Y.; Arnone, R. A.; Churnside, J. H.

2009-12-01

(Author List: Robert A Arnone, James H Churnside, Yongxiang Hu) Naval interests in ocean LIDAR systems has several areas which include the use of LIDAR for bathymetry mapping, underwater imaging systems and characterizing the vertical bio-optical scattering layers. Ocean LIDAR provides a new capability of extending surface bio-optical properties retrieved form ocean color imagery into the subsurface. The relationships between bio-optical scattering layers and physical properties such as mixed layer depth are being developed and LIDAR profiles can provide a significant contribution. These techniques for combining the vertical bio-optical structure with physical models and satellite ocean color using data assimilation are providing new capability in characterize the 3d ocean volume. The LIDAR capability in resolving the vertical ocean structure can provide the next generation remote sensing information for ocean characterization. Over the last ten years, NOAA has been developing and testing lidar for aerial surveys of fish schools and plankton aggregations. We have flown the lidar on numerous aircraft, ranging in size from a four-seat Cessna to a Casa twin-engine cargo plane. Surveys have covered both inland and offshore waters on both coasts of North America and the Atlantic waters of Europe. The species of interest have generally been near surface schooling fishes like sardines, anchovies, herring, mackerel, and menhaden. Plankton studies have included both zooplankton and phytoplankton. There are several general conclusions that can be drawn from the results of this work. The penetration depth of the lidar varies from about 15 m in very turbid inland waters to over 50 m in blue offshore waters. Reliable detection of fish schools and plankton layers requires filtering and application of a threshold to remove background scattering levels. The correlation between the results of a lidar survey and traditional acoustic or net surveys generally depends on the time delay between the two surveys. With no time delay the correlation is well above 0.9, and the correlation is essentially zero after about four days. The ocean lidar studies at NASA Langley Research Center started from the launch of the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) satellite. The lidar, designed for cloud and aerosol observation, also provides information about (1) ocean subsurface particulate backscatter, and (2) high resolution ocean surface wind speeds / mean square wave slopes. More than three years of global ocean measurements from CALIPSO are analyzed and available to the community. Ocean and atmospheric seasonal and inter-annual variations are studied using the CALIPSO observations combined with measurements from other A-train satellites. Future studies at NASA Langley Research Center includes: (1) Improvement of CALIPSO ocean product; (2) Theoretical radiative transfer modeling, such as lidar multiple scatter and coupled ocean-atmospheric Stokes vector, and new retrieval concepts with combined lidar and multi-angle, multi-spectral polarimeter; (3) Aircraft based measurements of next generation lidar, polarimeter and hyperspectral measurements.

Ocean circulation studies

NASA Technical Reports Server (NTRS)

Koblinsky, C. J.

1984-01-01

Remotely sensed signatures of ocean surface characteristics from active and passive satellite-borne radiometers in conjunction with in situ data were utilized to examine the large scale, low frequency circulation of the world's oceans. Studies of the California Current, the Gulf of California, and the Kuroshio Extension Current in the western North Pacific were reviewed briefly. The importance of satellite oceanographic tools was emphasized.

Ocean-Atmosphere Interactions Modulate Irrigation's Climate Impacts

NASA Technical Reports Server (NTRS)

Krakauer, Nir Y.; Puma, Michael J.; Cook, Benjamin I.; Gentine, Pierre; Nazarenko, Larissa

2016-01-01

Numerous studies have focused on the local and regional climate effects of irrigated agriculture and other land cover and land use change (LCLUC) phenomena, but there are few studies on the role of ocean- atmosphere interaction in modulating irrigation climate impacts. Here, we compare simulations with and without interactive sea surface temperatures of the equilibrium effect on climate of contemporary (year 2000) irrigation geographic extent and intensity. We find that ocean-atmosphere interaction does impact the magnitude of global-mean and spatially varying climate impacts, greatly increasing their global reach. Local climate effects in the irrigated regions remain broadly similar, while non-local effects, particularly over the oceans, tend to be larger. The interaction amplifies irrigation-driven standing wave patterns in the tropics and mid-latitudes in our simulations, approximately doubling the global-mean amplitude of surface temperature changes due to irrigation. The fractions of global area experiencing significant annual-mean surface air temperature and precipitation change also approximately double with ocean-atmosphere interaction. Subject to confirmation with other models, these findings imply that LCLUC is an important contributor to climate change even in remote areas such as the Southern Ocean, and that attribution studies should include interactive oceans and need to consider LCLUC, including irrigation, as a truly global forcing that affects climate and the water cycle over ocean as well as land areas.

Coastal processes study at Ocean Beach, San Francisco, CA: summary of data collection 2004-2006

USGS Publications Warehouse

Barnard, Patrick L.; Eshleman, Jodi; Erikson, Li H.; Hanes, Daniel M.

2007-01-01

Ocean Beach in San Francisco, California, contains a persistent erosional section in the shadow of the San Francisco ebb tidal delta and south of Sloat Boulevard that threatens valuable public infrastructure as well as the safe recreational use of the beach. Coastal managers have been discussing potential mediation measures for over a decade, with little scientific research available to aid in decision making. The United States Geological Survey (USGS) initiated the Ocean Beach Coastal Processes Study in April 2004 to provide the scientific knowledge necessary for coastal managers to make informed management decisions. This study integrates a wide range of field data collection and numerical modeling techniques to document nearshore sediment transport processes at the mouth of San Francisco Bay, with emphasis on how these processes relate to erosion at Ocean Beach. The Ocean Beach Coastal Processes Study is the first comprehensive study of coastal processes at the mouth of San Francisco Bay.

Arctic Ice-Ocean Coupling and Gyre Equilibration Observed With Remote Sensing

NASA Astrophysics Data System (ADS)

Dewey, Sarah; Morison, James; Kwok, Ronald; Dickinson, Suzanne; Morison, David; Andersen, Roger

2018-02-01

Model and observational evidence has shown that ocean current speeds in the Beaufort Gyre have increased and recently stabilized. Because these currents rival ice drift speeds, we examine the potential for the Beaufort Gyre's shift from a system in which the wind drives the ice and the ice drives a passive ocean to one in which the ocean often, in the absence of high winds, drives the ice. The resultant stress exerted on the ocean by the ice and the resultant Ekman pumping are reversed, without any change in average wind stress curl. Through these curl reversals, the ice-ocean stress provides a key feedback in Beaufort Gyre stabilization. This manuscript constitutes one of the first observational studies of ice-ocean stress inclusive of geostrophic ocean currents, by making use of recently available remote sensing data.

Maritime Aerosol Network as a Component of AERONET - First Results and Comparison with Global Aerosol Models and Satellite Retrievals

NASA Technical Reports Server (NTRS)

Smirnov, A.; Holben, B. N.; Giles, D. M.; Slutsker, I.; O'Neill, N. T.; Eck, T. F.; Macke, A.; Croot, P.; Courcoux, Y.; Sakerin, S. M.;

The reinvigoration of the Southern Ocean carbon sink.

PubMed

Landschützer, Peter; Gruber, Nicolas; Haumann, F Alexander; Rödenbeck, Christian; Bakker, Dorothee C E; van Heuven, Steven; Hoppema, Mario; Metzl, Nicolas; Sweeney, Colm; Takahashi, Taro; Tilbrook, Bronte; Wanninkhof, Rik

2015-09-11

Several studies have suggested that the carbon sink in the Southern Ocean-the ocean's strongest region for the uptake of anthropogenic CO2 -has weakened in recent decades. We demonstrated, on the basis of multidecadal analyses of surface ocean CO2 observations, that this weakening trend stopped around 2002, and by 2012, the Southern Ocean had regained its expected strength based on the growth of atmospheric CO2. All three Southern Ocean sectors have contributed to this reinvigoration of the carbon sink, yet differences in the processes between sectors exist, related to a tendency toward a zonally more asymmetric atmospheric circulation. The large decadal variations in the Southern Ocean carbon sink suggest a rather dynamic ocean carbon cycle that varies more in time than previously recognized. Copyright © 2015, American Association for the Advancement of Science.

Maritime Aerosol Network as a component of AERONET - first results and comparison with global aerosol models and satellite retrievals

NASA Astrophysics Data System (ADS)

Smirnov, A.; Holben, B. N.; Giles, D. M.; Slutsker, I.; O'Neill, N. T.; Eck, T. F.; Macke, A.; Croot, P.; Courcoux, Y.; Sakerin, S. M.; Smyth, T. J.; Zielinski, T.; Zibordi, G.; Goes, J. I.; Harvey, M. J.; Quinn, P. K.; Nelson, N. B.; Radionov, V. F.; Duarte, C. M.; Losno, R.; Sciare, J.; Voss, K. J.; Kinne, S.; Nalli, N. R.; Joseph, E.; Krishna Moorthy, K.; Covert, D. S.; Gulev, S. K.; Milinevsky, G.; Larouche, P.; Belanger, S.; Horne, E.; Chin, M.; Remer, L. A.; Kahn, R. A.; Reid, J. S.; Schulz, M.; Heald, C. L.; Zhang, J.; Lapina, K.; Kleidman, R. G.; Griesfeller, J.; Gaitley, B. J.; Tan, Q.; Diehl, T. L.

2011-01-01

The Maritime Aerosol Network (MAN) has been collecting data over the oceans since November 2006. Over 80 cruises were completed through early 2010 with deployments continuing. Measurements areas included various parts of the Atlantic Ocean, the Northern and Southern Pacific Ocean, the South Indian Ocean, the Southern Ocean, the Arctic Ocean and inland seas. MAN deploys Microtops hand-held sunphotometers and utilizes a calibration procedure and data processing traceable to AERONET. Data collection included areas that previously had no aerosol optical depth (AOD) coverage at all, particularly vast areas of the Southern Ocean. The MAN data archive provides a valuable resource for aerosol studies in maritime environments. In the current paper we present results of AOD measurements over the oceans, and make a comparison with satellite AOD retrievals and model simulations.

Maritime aerosol network as a component of AERONET - first results and comparison with global aerosol models and satellite retrievals

NASA Astrophysics Data System (ADS)

Smirnov, A.; Holben, B. N.; Giles, D. M.; Slutsker, I.; O'Neill, N. T.; Eck, T. F.; Macke, A.; Croot, P.; Courcoux, Y.; Sakerin, S. M.; Smyth, T. J.; Zielinski, T.; Zibordi, G.; Goes, J. I.; Harvey, M. J.; Quinn, P. K.; Nelson, N. B.; Radionov, V. F.; Duarte, C. M.; Losno, R.; Sciare, J.; Voss, K. J.; Kinne, S.; Nalli, N. R.; Joseph, E.; Krishna Moorthy, K.; Covert, D. S.; Gulev, S. K.; Milinevsky, G.; Larouche, P.; Belanger, S.; Horne, E.; Chin, M.; Remer, L. A.; Kahn, R. A.; Reid, J. S.; Schulz, M.; Heald, C. L.; Zhang, J.; Lapina, K.; Kleidman, R. G.; Griesfeller, J.; Gaitley, B. J.; Tan, Q.; Diehl, T. L.

2011-03-01

The Maritime Aerosol Network (MAN) has been collecting data over the oceans since November 2006. Over 80 cruises were completed through early 2010 with deployments continuing. Measurement areas included various parts of the Atlantic Ocean, the Northern and Southern Pacific Ocean, the South Indian Ocean, the Southern Ocean, the Arctic Ocean and inland seas. MAN deploys Microtops hand-held sunphotometers and utilizes a calibration procedure and data processing traceable to AERONET. Data collection included areas that previously had no aerosol optical depth (AOD) coverage at all, particularly vast areas of the Southern Ocean. The MAN data archive provides a valuable resource for aerosol studies in maritime environments. In the current paper we present results of AOD measurements over the oceans, and make a comparison with satellite AOD retrievals and model simulations.

Deep-ocean basalts: inert gas content and uncertainties in age dating.

PubMed

Noble, C S; Naughton, J J

1968-10-11

The radiogenic argon and helium contents of three basalts erupted into the deep ocean from an active volcano (Kilauea) have been measured. Ages calculated from these measurements increase with sample depth up to 22 million years for lavas deduced to be recent. Caution is urged in applying dates from deep-ocean basalts in studies on ocean-floor spreading.

Neural Networks Technique for Filling Gaps in Satellite Measurements: Application to Ocean Color Observations.

PubMed

Krasnopolsky, Vladimir; Nadiga, Sudhir; Mehra, Avichal; Bayler, Eric; Behringer, David

2016-01-01

A neural network (NN) technique to fill gaps in satellite data is introduced, linking satellite-derived fields of interest with other satellites and in situ physical observations. Satellite-derived "ocean color" (OC) data are used in this study because OC variability is primarily driven by biological processes related and correlated in complex, nonlinear relationships with the physical processes of the upper ocean. Specifically, ocean color chlorophyll-a fields from NOAA's operational Visible Imaging Infrared Radiometer Suite (VIIRS) are used, as well as NOAA and NASA ocean surface and upper-ocean observations employed--signatures of upper-ocean dynamics. An NN transfer function is trained, using global data for two years (2012 and 2013), and tested on independent data for 2014. To reduce the impact of noise in the data and to calculate a stable NN Jacobian for sensitivity studies, an ensemble of NNs with different weights is constructed and compared with a single NN. The impact of the NN training period on the NN's generalization ability is evaluated. The NN technique provides an accurate and computationally cheap method for filling in gaps in satellite ocean color observation fields and time series.

Neural Networks Technique for Filling Gaps in Satellite Measurements: Application to Ocean Color Observations

PubMed Central

Nadiga, Sudhir; Mehra, Avichal; Bayler, Eric; Behringer, David

2016-01-01

A neural network (NN) technique to fill gaps in satellite data is introduced, linking satellite-derived fields of interest with other satellites and in situ physical observations. Satellite-derived “ocean color” (OC) data are used in this study because OC variability is primarily driven by biological processes related and correlated in complex, nonlinear relationships with the physical processes of the upper ocean. Specifically, ocean color chlorophyll-a fields from NOAA's operational Visible Imaging Infrared Radiometer Suite (VIIRS) are used, as well as NOAA and NASA ocean surface and upper-ocean observations employed—signatures of upper-ocean dynamics. An NN transfer function is trained, using global data for two years (2012 and 2013), and tested on independent data for 2014. To reduce the impact of noise in the data and to calculate a stable NN Jacobian for sensitivity studies, an ensemble of NNs with different weights is constructed and compared with a single NN. The impact of the NN training period on the NN's generalization ability is evaluated. The NN technique provides an accurate and computationally cheap method for filling in gaps in satellite ocean color observation fields and time series. PMID:26819586

Coastal Jets, Oceanic Upwelling, Mesoscale Eddies, and Clouds in the Southeast Pacific

NASA Astrophysics Data System (ADS)

Hong, X.; Wang, S.; Jiang, Q.; O'Neill, L. W.; Hodur, R.; Chen, S.; Martin, P.; Cummings, J. A.

2009-12-01

Coastal jets, oceanic upwelling, mesoscale eddies, and clouds in the Southeast Pacific (SEP) are studied using the two-way-coupled COAMPS/NCOM system with the NCODA for the ocean data assimilation. The coupled system was run for the period of the VAMOS Ocean-Cloud-Atmosphere-Land Study (VOCALS) field campaign from 20 October to 30 November, 2008. The investigation of the feedback between the atmosphere and the ocean is focused on the periods of the strong and the weak coastal jets. During the strong coastal jet period, colder and drier air along the coast results in larger surface heat fluxes and increased boundary layer height. More extensive and organized clouds are generated in the strongly unstable conditions in the atmospheric boundary layer. The oceanic upwelling is stronger and the upwelled cold water extends further offshore. During the weak coastal jet period, the cyclonic and anti-cyclonic oceanic eddies propagate westward more significantly. The inertial oscillations induced by the variations of the wind stress also increase in strength with stronger phase shifts between the oscillations in the upper and the lower layers of the ocean. In addition, the model results from the coupled system were evaluated with available observations from the VOCALS field campaign.

Recommendations for Obesity Clinical Trials in Cancer Survivors: American Society of Clinical Oncology Statement.

PubMed

Ligibel, Jennifer A; Alfano, Catherine M; Hershman, Dawn; Ballard, Rachel M; Bruinooge, Suanna S; Courneya, Kerry S; Daniels, Elvan C; Demark-Wahnefried, Wendy; Frank, Elizabeth S; Goodwin, Pamela J; Irwin, Melinda L; Levit, Laura A; McCaskill-Stevens, Worta; Minasian, Lori M; O'Rourke, Mark A; Pierce, John P; Stein, Kevin D; Thomson, Cynthia A; Hudis, Clifford A

2015-11-20

Observational evidence has established a relationship between obesity and cancer risk and outcomes. Interventional studies have demonstrated the feasibility and benefits of lifestyle change after cancer diagnosis, and guidelines recommend weight management and regular physical activity in cancer survivors; however, lifestyle interventions are not a routine part of cancer care. The ASCO Research Summit on Advancing Obesity Clinical Trials in Cancer Survivors sought to identify the knowledge gaps that clinical trials addressing energy balance factors in cancer survivors have not answered and to develop a roadmap for the design and implementation of studies with the potential to generate data that could lead to the evidence-based incorporation of weight management and physical activity programs into standard oncology practice. Recommendations highlight the need for large-scale trials evaluating the impact of energy balance interventions on cancer outcomes, as well as the concurrent conduct of studies focused on dissemination and implementation of interventions in diverse populations of cancer survivors, including answering critical questions about the degree of benefit in key subgroups of survivors. Other considerations include the importance of incorporating economic metrics into energy balance intervention trials, the need to establish intermediate biomarkers, and the importance of integrating traditional and nontraditional funding sources. Establishing lifestyle change after cancer diagnosis as a routine part of cancer care will require a multipronged effort to overcome barriers related to study development, funding, and stakeholder engagement. Given the prevalence of obesity and inactivity in cancer survivors in the United States and elsewhere, energy balance interventions hold the potential to reduce cancer morbidity and mortality in millions of patients, and it is essential that we move forward in determining their role in cancer care with the same care and precision used to test pharmacologic and other interventions.

Clinical Practices and Outcomes on Chemotherapy-Induced Nausea and Vomiting Management in South Korea: Comparison with Asia-Pacific Data of the Pan Australasian Chemotherapy Induced Emesis Burden of Illness Study

PubMed Central

Lee, Myung Ah; Cho, Eun Kyung; Oh, Sung Yong; Ahn, Joong Bae; Lee, Ji Yun; Thomas, Burke; Jung, Hun; Kim, Jong Gwang

2016-01-01

Purpose This study reported patient outcomes of chemotherapy-induced nausea and vomiting (CINV) prophylaxis for highly emetogenic chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC) regimens and evaluated its adherence to acute-phase CINV prophylaxis in the Korean population subset of the Pan Australasian Chemotherapy Induced Emesis burden of illness (PrACTICE) study. Materials and Methods This subgroup analysis evaluated 158 Korean patients receiving HEC or MEC and compared the data (wherever possible) with that of 648 patients from the Asia-Pacific (AP) region. Study endpoints included evaluation of primary CINV prophylaxis and adherence to acute-phase CINV prophylaxis in cycle 1 (American Society of Clinical Oncology [ASCO] Quality Oncology Practice Initiative [QOPI]). Results In South Korea and the AP, a 5-hydroxytryptamine-3 receptor antagonist (5HT3-RA) prophylaxis for the acute phase was administered to 79/80 patients (98.8%) for HEC and 70/71 patients (98.6%) for MEC regimens (QOPI-1). Triple regimen (corticosteroid–5HT3-RA–neurokinin 1-RA) was initiated in 46/80 patients (57.5%) for prophylaxis of acute CINV in cycle 1 of HEC (QOPI-3). Double regimen (corticosteroid–5HT3-RA, with or within NK1-RA) was initiated in 61/71 patients (83.1%) for control of acute CINV in cycle 1 of MEC a(QOPI-2). Conclusion Active management of CINV is necessary in cycle 1 of HEC in South Korea, despite higher rates than the AP region. Adherence to the international guidelines for CINV prophylaxis requires attention in the acute phase in cycle 1 of the HEC regimen. PMID:26875197

Remote sensing tools to study ocean biogeochemistry: state of the art

NASA Technical Reports Server (NTRS)

Carr, M. E.

2001-01-01

Remote sensing of the world ocean presently provides measurements of sea-surface temperature, sea surface height, wind speed and direction, and ocean color, from which chlorophyll concentration and aerosol optical thickness are obtained.

Ocean state estimation for climate studies

NASA Technical Reports Server (NTRS)

Lee, T.

2002-01-01

Climate variabilities, which are of interest to CLIVAR, involve a broad range of spatial and temporal scales. Ocean state estimation (often referred to as ocean data assimilation), by optimally combining observations and models, becomes an important element of CLIVAR.

Spaceborne Lidar in the Study of Marine Systems.

PubMed

Hostetler, Chris A; Behrenfeld, Michael J; Hu, Yongxiang; Hair, Johnathan W; Schulien, Jennifer A

2018-01-03

Satellite passive ocean color instruments have provided an unbroken ∼20-year record of global ocean plankton properties, but this measurement approach has inherent limitations in terms of spatial-temporal sampling and ability to resolve vertical structure within the water column. These limitations can be addressed by coupling ocean color data with measurements from a spaceborne lidar. Airborne lidars have been used for decades to study ocean subsurface properties, but recent breakthroughs have now demonstrated that plankton properties can be measured with a satellite lidar. The satellite lidar era in oceanography has arrived. Here, we present a review of the lidar technique, its applications in marine systems, a perspective on what can be accomplished in the near future with an ocean- and atmosphere-optimized satellite lidar, and a vision for a multiplatform virtual constellation of observational assets that would enable a three-dimensional reconstruction of global ocean ecosystems.

Individual and population-level responses to ocean acidification.

PubMed

Harvey, Ben P; McKeown, Niall J; Rastrick, Samuel P S; Bertolini, Camilla; Foggo, Andy; Graham, Helen; Hall-Spencer, Jason M; Milazzo, Marco; Shaw, Paul W; Small, Daniel P; Moore, Pippa J

2016-01-29

Ocean acidification is predicted to have detrimental effects on many marine organisms and ecological processes. Despite growing evidence for direct impacts on specific species, few studies have simultaneously considered the effects of ocean acidification on individuals (e.g. consequences for energy budgets and resource partitioning) and population level demographic processes. Here we show that ocean acidification increases energetic demands on gastropods resulting in altered energy allocation, i.e. reduced shell size but increased body mass. When scaled up to the population level, long-term exposure to ocean acidification altered population demography, with evidence of a reduction in the proportion of females in the population and genetic signatures of increased variance in reproductive success among individuals. Such increased variance enhances levels of short-term genetic drift which is predicted to inhibit adaptation. Our study indicates that even against a background of high gene flow, ocean acidification is driving individual- and population-level changes that will impact eco-evolutionary trajectories.

Spaceborne Lidar in the Study of Marine Systems

NASA Astrophysics Data System (ADS)

Hostetler, Chris A.; Behrenfeld, Michael J.; Hu, Yongxiang; Hair, Johnathan W.; Schulien, Jennifer A.

2018-01-01

Satellite passive ocean color instruments have provided an unbroken ˜20-year record of global ocean plankton properties, but this measurement approach has inherent limitations in terms of spatial-temporal sampling and ability to resolve vertical structure within the water column. These limitations can be addressed by coupling ocean color data with measurements from a spaceborne lidar. Airborne lidars have been used for decades to study ocean subsurface properties, but recent breakthroughs have now demonstrated that plankton properties can be measured with a satellite lidar. The satellite lidar era in oceanography has arrived. Here, we present a review of the lidar technique, its applications in marine systems, a perspective on what can be accomplished in the near future with an ocean- and atmosphere-optimized satellite lidar, and a vision for a multiplatform virtual constellation of observational assets that would enable a three-dimensional reconstruction of global ocean ecosystems.

Estimation of Surface Seawater Fugacity of Carbon Dioxide Using Satellite Data and Machine Learning

NASA Astrophysics Data System (ADS)

Jang, E.; Im, J.; Park, G.; Park, Y.

2016-12-01

The ocean controls the climate of Earth by absorbing and releasing CO2 through the carbon cycle. The amount of CO2 in the ocean has increased since the industrial revolution. High CO2 concentration in the ocean has a negative influence to marine organisms and reduces the ability of absorbing CO2 in the ocean. This study estimated surface seawater fugacity of CO2 (fCO2) in the East Sea of Korea using Geostationary Ocean Color Imager (GOCI) and Moderate Resolution Imaging Spectroradiometer (MODIS) satellite data, and Hybrid Coordinate Ocean Model (HYCOM) reanalysis data. GOCI is the world first geostationary ocean color observation satellite sensor, and it provides 8 images with 8 bands hourly per day from 9 am to 4 pm at 500m resolution. Two machine learning approaches (i.e., random forest and support vector regression) were used to model fCO2 in this study. While most of the existing studies used multiple linear regression to estimate the pressure of CO2 in the ocean, machine learning may handle more complex relationship between surface seawater fCO2 and ocean parameters in a dynamic spatiotemporal environment. Five ocean related parameters, colored dissolved organic matter (CDOM), chlorophyll-a (chla), sea surface temperature (SST), sea surface salinity (SSS), and mixed layer depth (MLD), were used as input variables. This study examined two schemes, one with GOCI-derived products and the other with MODIS-derived ones. Results show that random forest performed better than support vector regression regardless of satellite data used. The accuracy of GOCI-based estimation was higher than MODIS-based one, possibly thanks to the better spatiotemporal resolution of GOCI data. MLD was identified the most contributing parameter in estimating surface seawater fCO2 among the five ocean related parameters, which might be related with an active deep convection in the East Sea. The surface seawater fCO2 in summer was higher in general with some spatial variation than the other seasons because of higher SST.

Determining the Ocean's Role on the Variable Gravity Field on Earth Rotation

NASA Technical Reports Server (NTRS)

Ponte, Rui M.

1999-01-01

A number of ocean models of different complexity have been used to study changes in the oceanic mass field and angular momentum and their relation to the variable Earth rotation and gravity field. Time scales examined range from seasonal to a few days. Results point to the importance of oceanic signals in driving polar motion, in particular the Chandler and annual wobbles. Results also show that oceanic signals have a measurable impact on length-of-day variations. Various circulation features and associated mass signals, including the North Pacific subtropical gyre, the equatorial currents, and the Antarctic Circumpolar Current play a significant role in oceanic angular momentum variability.

The influence of the ocean circulation state on ocean carbon storage and CO2 drawdown potential in an Earth system model

NASA Astrophysics Data System (ADS)

Ödalen, Malin; Nycander, Jonas; Oliver, Kevin I. C.; Brodeau, Laurent; Ridgwell, Andy

2018-03-01

During the four most recent glacial cycles, atmospheric CO2 during glacial maxima has been lowered by about 90-100 ppm with respect to interglacials. There is widespread consensus that most of this carbon was partitioned in the ocean. It is, however, still debated which processes were dominant in achieving this increased carbon storage. In this paper, we use an Earth system model of intermediate complexity to explore the sensitivity of ocean carbon storage to ocean circulation state. We carry out a set of simulations in which we run the model to pre-industrial equilibrium, but in which we achieve different states of ocean circulation by changing forcing parameters such as wind stress, ocean diffusivity and atmospheric heat diffusivity. As a consequence, the ensemble members also have different ocean carbon reservoirs, global ocean average temperatures, biological pump efficiencies and conditions for air-sea CO2 disequilibrium. We analyse changes in total ocean carbon storage and separate it into contributions by the solubility pump, the biological pump and the CO2 disequilibrium component. We also relate these contributions to differences in the strength of the ocean overturning circulation. Depending on which ocean forcing parameter is tuned, the origin of the change in carbon storage is different. When wind stress or ocean diapycnal diffusivity is changed, the response of the biological pump gives the most important effect on ocean carbon storage, whereas when atmospheric heat diffusivity or ocean isopycnal diffusivity is changed, the solubility pump and the disequilibrium component are also important and sometimes dominant. Despite this complexity, we obtain a negative linear relationship between total ocean carbon and the combined strength of the northern and southern overturning cells. This relationship is robust to different reservoirs dominating the response to different forcing mechanisms. Finally, we conduct a drawdown experiment in which we investigate the capacity for increased carbon storage by artificially maximising the efficiency of the biological pump in our ensemble members. We conclude that different initial states for an ocean model result in different capacities for ocean carbon storage due to differences in the ocean circulation state and the origin of the carbon in the initial ocean carbon reservoir. This could explain why it is difficult to achieve comparable responses of the ocean carbon pumps in model inter-comparison studies in which the initial states vary between models. We show that this effect of the initial state is quantifiable. The drawdown experiment highlights the importance of the strength of the biological pump in the control state for model studies of increased biological efficiency.

Rayleigh Wave Phase Velocity in the Upper Mantle Beneath the Indian Ocean

NASA Astrophysics Data System (ADS)

Godfrey, K. E.; Dalton, C. A.; Ritsema, J.

2016-12-01

Most of what is currently understood about the seismic properties of oceanic upper mantle is based on either global studies or regional studies of the upper mantle beneath the Pacific Ocean. However, global seismic models and geochemical studies of mid-ocean ridge basalts indicate differences in the properties of the upper mantle beneath the Pacific, Atlantic, and Indian oceans. Though the Indian Ocean is not as well studied seismically, it is host to a number of geologically interesting features including 16,000 km of mid-ocean ridge with a range of spreading rates from 14 mm/yr along the Southwest Indian Ridge to 55-75 mm/yr along the Southeast Indian Ridge. The Indian Ocean also contains multiple volcanic hotspots, the Australian-Antarctic Discordance, and a low geoid anomaly south of India, and it overlies a portion of a large low-shear-velocity province. We are using Rayleigh waves to construct a high-resolution seismic velocity model of the Indian Ocean upper mantle. We utilize a global dataset of phase delays measured at 20 periods, between 37 and 375 seconds; the dataset includes between 700 and 20,000 that traverse our study region exclusively, with a larger number of paths at shorter periods. We explore variations in phase velocity using two separate approaches. One, we allow phase velocity to vary only as a function of seafloor age. Two, we perform a damped least-squares inversion to solve for 2-D phase velocity maps at each period. Preliminary results indicate low velocities along the Southeast Indian Ridge and Central Indian Ridge, but the expected low velocities are less apparent along the slow-spreading Southwest Indian Ridge. We observe a region of fast velocities extending from Antarctica northward between the Kerguelen and Crozet hotspots, and lower than expected velocities beneath the Reunion hotspot. Additionally, we find low velocities associated with a region of extinct seafloor spreading in the Wharton basin.

Exploring the Inner Edge of the Habitable Zone with Fully Coupled Oceans

NASA Technical Reports Server (NTRS)

Way, M.J; Del Genio, A.D.; Kelley, M.; Aleinov, I.; Clune, T.

2015-01-01

The role of rotation in planetary atmospheres plays an important role in regulating atmospheric and oceanic heat flow, cloud formation and precipitation. Using the Goddard Institute for Space Studies (GISS) three dimension General Circulation Model (3D-GCM) we demonstrate how varying rotation rate and increasing the incident solar flux on a planet are related to each other and may allow the inner edge of the habitable zone to be much closer than many previous habitable zone studies have indicated. This is shown in particular for fully coupled ocean runs -- some of the first that have been utilized in this context. Results with a 100m mixed layer depth and our fully coupled ocean runs are compared with those of Yang et al. 2014, which demonstrates consistency across models. However, there are clear differences for rotations rates of 1-16x present earth day lengths between the mixed layer and fully couple ocean models, which points to the necessity of using fully coupled oceans whenever possible. The latter was recently demonstrated quite clearly by Hu & Yang 2014 in their aquaworld study with a fully coupled ocean when compared with similar mixed layer ocean studies and by Cullum et al. 2014. Atmospheric constituent amounts were also varied alongside adjustments to cloud parameterizations (results not shown here). While the latter have an effect on what a planet's global mean temperature is once the oceans reach equilibrium they do not qualitatively change the overall relationship between the globally averaged surface temperature and incident solar flux for rotation rates ranging from 1 to 256 times the present Earth day length. At the same time this study demonstrates that given the lack of knowledge about the atmospheric constituents and clouds on exoplanets there is still a large uncertainty as to where a planet will sit in a given star's habitable zone.

Modeling mid-ocean ridge hydrothermal response to earthquakes, tides, and ocean currents: a case study at the Grotto mound, Endeavour Segment, Juan de Fuca Ridge

NASA Astrophysics Data System (ADS)

Xu, G.; Bemis, K. G.

2014-12-01

Seafloor hydrothermal systems feature intricate interconnections among oceanic, geological, hydrothermal, and biological processes. The advent of the NEPTUNE observatory operated by Ocean Networks Canada at the Endeavour Segment, Juan de Fuca Ridge enables scientists to study these interconnections through multidisciplinary, continuous, real-time observations. The multidisciplinary observatory instruments deployed at the Grotto Mound, a major study site of the NEPTUNE observatory, makes it a perfect place to study the response of a seafloor hydrothermal system to geological and oceanic processes. In this study, we use the multidisciplinary datasets recorded by the NEPTUNE Observatory instruments as observational tools to demonstrate two different aspects of the response of hydrothermal activity at the Grotto Mound to geological and oceanic processes. First, we investigate a recent increase in venting temperature and heat flux at Grotto observed by the Benthic and Resistivity Sensors (BARS) and the Cabled Observatory Vent Imaging Sonar (COVIS) respectively. This event started in Mar 2014 and is still evolving by the time of writing this abstract. An initial interpretation in light of the seismic data recorded by a neighboring ocean bottom seismometer on the NEPTUNE observatory suggests the temperature and heat flux increase is probably triggered by local seismic activities. Comparison of the observations with the results of a 1-D mathematical model simulation of hydrothermal sub-seafloor circulation elucidates the potential mechanisms underlying hydrothermal response to local earthquakes. Second, we observe significant tidal oscillations in the venting temperature time series recorded by BARS and the acoustic imaging of hydrothermal plumes by COVIS, which is evidence for hydrothermal response to ocean tides and currents. We interpret the tidal oscillations of venting temperature as a result of tidal loading on a poroelastic medium. We then invoke poroelastic theories to estimate the crustal permeability, a fundamental property of subsurface hydrothermal circulation, from the phase shift of the tidal oscillations of venting temperature relative to ambient ocean tides. These results together shed light on the influences of seismic and oceanic processes on a seafloor hydrothermal system.

The Ocean Carbon States Database: a proof-of-concept application of cluster analysis in the ocean carbon cycle

NASA Astrophysics Data System (ADS)

Latto, Rebecca; Romanou, Anastasia

2018-03-01

In this paper, we present a database of the basic regimes of the carbon cycle in the ocean, the ocean carbon states, as obtained using a data mining/pattern recognition technique in observation-based as well as model data. The goal of this study is to establish a new data analysis methodology, test it and assess its utility in providing more insights into the regional and temporal variability of the marine carbon cycle. This is important as advanced data mining techniques are becoming widely used in climate and Earth sciences and in particular in studies of the global carbon cycle, where the interaction of physical and biogeochemical drivers confounds our ability to accurately describe, understand, and predict CO2 concentrations and their changes in the major planetary carbon reservoirs. In this proof-of-concept study, we focus on using well-understood data that are based on observations, as well as model results from the NASA Goddard Institute for Space Studies (GISS) climate model. Our analysis shows that ocean carbon states are associated with the subtropical-subpolar gyre during the colder months of the year and the tropics during the warmer season in the North Atlantic basin. Conversely, in the Southern Ocean, the ocean carbon states can be associated with the subtropical and Antarctic convergence zones in the warmer season and the coastal Antarctic divergence zone in the colder season. With respect to model evaluation, we find that the GISS model reproduces the cold and warm season regimes more skillfully in the North Atlantic than in the Southern Ocean and matches the observed seasonality better than the spatial distribution of the regimes. Finally, the ocean carbon states provide useful information in the model error attribution. Model air-sea CO2 flux biases in the North Atlantic stem from wind speed and salinity biases in the subpolar region and nutrient and wind speed biases in the subtropics and tropics. Nutrient biases are shown to be most important in the Southern Ocean flux bias. All data and analysis scripts are available at https://data.giss.nasa.gov/oceans/carbonstates/ (DOI: https://doi.org/10.5281/zenodo.996891).

Analysis of Atmosphere-Ocean Surface Flux Feedbacks in Recent Satellite and Model Reanalysis Products

NASA Technical Reports Server (NTRS)

Roberts, J. Brent; Robertson, F. R.; Clayson, C. A.

2010-01-01

Recent investigations have examined observations in an attempt to determine when and how the ocean forces the atmosphere, and vice versa. These studies focus primarily on relationships between sea surface temperature anomalies and the turbulent and radiative surface heat fluxes. It has been found that both positive and negative feedbacks, which enhance or reduce sea surface temperature anomaly amplitudes, can be generated through changes in the surface boundary layer. Consequent changes in sea surface temperature act to change boundary layer characteristics through changes in static stability or turbulent fluxes. Previous studies over the global oceans have used coarse-resolution observational and model products such as ICOADS and the NCEP Reanalysis. This study focuses on documenting the atmosphere ocean feedbacks that exist in recently produced higher resolution products, namely the SeaFlux v1.0 product and the NASA Modern Era Retrospective-Analysis for Research and Applications (MERRA). It has been noted in recent studies that evidence of oceanic forcing of the atmosphere exists on smaller scales than the usually more dominant atmospheric forcing of the ocean, particularly in higher latitudes. It is expected that use of these higher resolution products will allow for a more comprehensive description of these small-scale ocean-atmosphere feedbacks. The SeaFlux intercomparisons have revealed large scatter between various surface flux climatologies. This study also investigates the uncertainty in surface flux feedbacks based on several of these recent satellite based climatologies

Surface properties of ocean fronts

NASA Technical Reports Server (NTRS)

Wolff, P. M.; Hubert, W. E.

1976-01-01

Background information on oceanic fronts is presented and the results of several models which were developed to study the dynamics of oceanic fronts and their effects on various surface properties are described. The details of the four numerical models used in these studies are given in separate appendices which contain all of the physical equations, program documentation and running instructions for the models.

Impact of atmospheric and terrestrial CO2 feedbacks on fertilization-induced marine carbon uptake

NASA Astrophysics Data System (ADS)

Oschlies, A.

2009-08-01

The sensitivity of oceanic CO2 uptake to alterations in the marine biological carbon pump, such as brought about by natural or purposeful ocean fertilization, has repeatedly been investigated by studies employing numerical biogeochemical ocean models. It is shown here that the results of such ocean-centered studies are very sensitive to the assumption made about the response of the carbon reservoirs on the atmospheric side of the sea surface. Assumptions made include prescribed atmospheric pCO2, an interactive atmospheric CO2 pool exchanging carbon with the ocean but not with the terrestrial biosphere, and an interactive atmosphere that exchanges carbon with both oceanic and terrestrial carbon pools. The impact of these assumptions on simulated annual to millennial oceanic carbon uptake is investigated for a hypothetical increase in the C:N ratio of the biological pump and for an idealized enhancement of phytoplankton growth. Compared to simulations with interactive atmosphere, using prescribed atmospheric pCO2 overestimates the sensitivity of the oceanic CO2 uptake to changes in the biological pump, by about 2%, 25%, 100%, and >500% on annual, decadal, centennial, and millennial timescales, respectively. The smaller efficiency of the oceanic carbon uptake under an interactive atmosphere is due to the back flux of CO2 that occurs when atmospheric CO2 is reduced. Adding an interactive terrestrial carbon pool to the atmosphere-ocean model system has a small effect on annual timescales, but increases the simulated fertilization-induced oceanic carbon uptake by about 4%, 50%, and 100% on decadal, centennial, and millennial timescales, respectively, for pCO2 sensitivities of the terrestrial carbon storage in the middle range of the C4MIP models (Friedlingstein et al., 2006). For such sensitivities, a substantial fraction of oceanic carbon uptake induced by natural or purposeful ocean fertilization originates, on timescales longer than decades, not from the atmosphere but from the terrestrial biosphere.

Community input requested

NASA Astrophysics Data System (ADS)

Fine, Rana A.; Walker, Dan

In June 1996, the National Research Council (NRC) formed the Committee on Major U.S. Oceanographic Research Programs to foster coordination among the large programs (e.g., World Ocean Circulation Experiment, Ocean Drilling Program, Ridge Interdisciplinary Global Experiment, and others) and examine their role in ocean research. In particular, the committee is charged with (1) enhancing information sharing and the coordinated implementation of the research plans of the major ongoing and future programs; (2) assisting the federal agencies and ocean sciences community in identifying gaps, as well as appropriate followon activities to existing programs; (3) making recommendations on how future major ocean programs should be planned, structured and organized; and (4) evaluating the impact of major ocean programs on the understanding of the oceans, development of research facilities, education, and collegiality in the academic community. The activity was initiated at the request of the National Science Foundation (NSF) Division of Ocean Sciences, is overseen by the NRC's Ocean Studies Board (OSB), and is funded by both NSF and the Office of Naval Research.

Impact of oceanic-scale interactions on the seasonal modulation of ocean dynamics by the atmosphere.

PubMed

Sasaki, Hideharu; Klein, Patrice; Qiu, Bo; Sasai, Yoshikazu

2014-12-15

Ocean eddies (with a size of 100-300 km), ubiquitous in satellite observations, are known to represent about 80% of the total ocean kinetic energy. Recent studies have pointed out the unexpected role of smaller oceanic structures (with 1-50 km scales) in generating and sustaining these eddies. The interpretation proposed so far invokes the internal instability resulting from the large-scale interaction between upper and interior oceanic layers. Here we show, using a new high-resolution simulation of the realistic North Pacific Ocean, that ocean eddies are instead sustained by a different process that involves small-scale mixed-layer instabilities set up by large-scale atmospheric forcing in winter. This leads to a seasonal evolution of the eddy kinetic energy in a very large part of this ocean, with an amplitude varying by a factor almost equal to 2. Perspectives in terms of the impacts on climate dynamics and future satellite observational systems are briefly discussed.

Impact of oceanic-scale interactions on the seasonal modulation of ocean dynamics by the atmosphere

PubMed Central

Sasaki, Hideharu; Klein, Patrice; Qiu, Bo; Sasai, Yoshikazu

2014-01-01

Ocean eddies (with a size of 100–300 km), ubiquitous in satellite observations, are known to represent about 80% of the total ocean kinetic energy. Recent studies have pointed out the unexpected role of smaller oceanic structures (with 1–50 km scales) in generating and sustaining these eddies. The interpretation proposed so far invokes the internal instability resulting from the large-scale interaction between upper and interior oceanic layers. Here we show, using a new high-resolution simulation of the realistic North Pacific Ocean, that ocean eddies are instead sustained by a different process that involves small-scale mixed-layer instabilities set up by large-scale atmospheric forcing in winter. This leads to a seasonal evolution of the eddy kinetic energy in a very large part of this ocean, with an amplitude varying by a factor almost equal to 2. Perspectives in terms of the impacts on climate dynamics and future satellite observational systems are briefly discussed. PMID:25501039

Ocean acoustic reverberation tomography.

PubMed

Dunn, Robert A

2015-12-01

Seismic wide-angle imaging using ship-towed acoustic sources and networks of ocean bottom seismographs is a common technique for exploring earth structure beneath the oceans. In these studies, the recorded data are dominated by acoustic waves propagating as reverberations in the water column. For surveys with a small receiver spacing (e.g., <10 km), the acoustic wave field densely samples properties of the water column over the width of the receiver array. A method, referred to as ocean acoustic reverberation tomography, is developed that uses the travel times of direct and reflected waves to image ocean acoustic structure. Reverberation tomography offers an alternative approach for determining the structure of the oceans and advancing the understanding of ocean heat content and mixing processes. The technique has the potential for revealing small-scale ocean thermal structure over the entire vertical height of the water column and along long survey profiles or across three-dimensional volumes of the ocean. For realistic experimental geometries and data noise levels, the method can produce images of ocean sound speed on a smaller scale than traditional acoustic tomography.

Deep Ocean Warming Assessed from Altimeters, GRACE, 3 In-situ Measurements, and a Non-Boussinesq OGCM

NASA Technical Reports Server (NTRS)

Song, Y. Tony; Colberg, Frank

2011-01-01

Observational surveys have shown significant oceanic bottom water warming, but they are too spatially and temporally sporadic to quantify the deep ocean contribution to the present-day sea level rise (SLR). In this study, altimetry sea surface height (SSH), Gravity Recovery and Climate Experiment (GRACE) ocean mass, and in situ upper ocean (0-700 m) steric height have been assessed for their seasonal variability and trend maps. It is shown that neither the global mean nor the regional trends of altimetry SLR can be explained by the upper ocean steric height plus the GRACE ocean mass. A non-Boussinesq ocean general circulation model (OGCM), allowing the sea level to rise as a direct response to the heat added into the ocean, is then used to diagnose the deep ocean steric height. Constrained by sea surface temperature data and the top of atmosphere (TOA) radiation measurements, the model reproduces the observed upper ocean heat content well. Combining the modeled deep ocean steric height with observational upper ocean data gives the full depth steric height. Adding a GRACE-estimated mass trend, the data-model combination explains not only the altimetry global mean SLR but also its regional trends fairly well. The deep ocean warming is mostly prevalent in the Atlantic and Indian oceans, and along the Antarctic Circumpolar Current, suggesting a strong relation to the oceanic circulation and dynamics. Its comparison with available bottom water measurements shows reasonably good agreement, indicating that deep ocean warming below 700 m might have contributed 1.1 mm/yr to the global mean SLR or one-third of the altimeter-observed rate of 3.11 +/- 0.6 mm/yr over 1993-2008.

Mapping Global Ocean Surface Albedo from Satellite Observations: Models, Algorithms, and Datasets

NASA Astrophysics Data System (ADS)

Li, X.; Fan, X.; Yan, H.; Li, A.; Wang, M.; Qu, Y.

2018-04-01

Ocean surface albedo (OSA) is one of the important parameters in surface radiation budget (SRB). It is usually considered as a controlling factor of the heat exchange among the atmosphere and ocean. The temporal and spatial dynamics of OSA determine the energy absorption of upper level ocean water, and have influences on the oceanic currents, atmospheric circulations, and transportation of material and energy of hydrosphere. Therefore, various parameterizations and models have been developed for describing the dynamics of OSA. However, it has been demonstrated that the currently available OSA datasets cannot full fill the requirement of global climate change studies. In this study, we present a literature review on mapping global OSA from satellite observations. The models (parameterizations, the coupled ocean-atmosphere radiative transfer (COART), and the three component ocean water albedo (TCOWA)), algorithms (the estimation method based on reanalysis data, and the direct-estimation algorithm), and datasets (the cloud, albedo and radiation (CLARA) surface albedo product, dataset derived by the TCOWA model, and the global land surface satellite (GLASS) phase-2 surface broadband albedo product) of OSA have been discussed, separately.

Ocean Optics Protocols for Satellite Ocean Color Sensor Validation. Volume 4; Inherent Optical Properties: Instruments, Characterizations, Field Measurements and Data Analysis Protocols; Revised

NASA Technical Reports Server (NTRS)

Mueller, J. L. (Editor); Fargion, Giuletta S. (Editor); McClain, Charles R. (Editor); Pegau, Scott; Zaneveld, J. Ronald V.; Mitchell, B. Gregg; Kahru, Mati; Wieland, John; Stramska, Malgorzat

2003-01-01

This document stipulates protocols for measuring bio-optical and radiometric data for the Sensor Intercomparison and Merger for Biological and Interdisciplinary Oceanic Studies (SIMBIOS) Project activities and algorithm development. The document is organized into 6 separate volumes as Ocean Optics Protocols for Satellite Ocean Color Sensor Validation, Revision 4. Volume I: Introduction, Background and Conventions; Volume II: Instrument Specifications, Characterization and Calibration; Volume III: Radiometric Measurements and Data Analysis Methods; Volume IV: Inherent Optical Properties: Instruments, Characterization, Field Measurements and Data Analysis Protocols; Volume V: Biogeochemical and Bio-Optical Measurements and Data Analysis Methods; Volume VI: Special Topics in Ocean Optics Protocols and Appendices. The earlier version of Ocean Optics Protocols for Satellite Ocean Color Sensor Validation, Revision 3 (Mueller and Fargion 2002, Volumes 1 and 2) is entirely superseded by the six volumes of Revision 4 listed above.

Remote sensing of chlorophyll in an atmosphere-ocean environment: a theoretical study.

PubMed

Kattawar, G W; Humphreys, T J

1976-01-01

A Monte Carlo program was written to compute the effect of chlorophyll on the ratio of upwelling to down-welling radiance and irradiance as a function of wavelength, height above the ocean, and depth within the ocean. This program simulates the actual physical situation, since a real atmospheric model was used, i.e., one that contained both aerosol and Rayleigh scattering as well as ozone absorption. The complete interaction of the radiation field with the ocean was also taken into account. The chlorophyll was assumed to be uniformly mixed in the ocean and was also assumed to act only as an absorbing agent. For the ocean model both scattering and absorption by hydrosols was included. Results have been obtained for both a very clear ocean and a medium turbid ocean. Recommendations are made for optimum techniques for remotely sensing chlorophyll both in situ and in vitro.

Effects of surface wave breaking on the oceanic boundary layer

NASA Astrophysics Data System (ADS)

He, Hailun; Chen, Dake

2011-04-01

Existing laboratory studies suggest that surface wave breaking may exert a significant impact on the formation and evolution of oceanic surface boundary layer, which plays an important role in the ocean-atmosphere coupled system. However, present climate models either neglect the effects of wave breaking or treat them implicitly through some crude parameterization. Here we use a one-dimensional ocean model (General Ocean Turbulence Model, GOTM) to investigate the effects of wave breaking on the oceanic boundary layer on diurnal to seasonal time scales. First a set of idealized experiments are carried out to demonstrate the basic physics and the necessity to include wave breaking. Then the model is applied to simulating observations at the northern North Sea and the Ocean Weather Station Papa, which shows that properly accounting for wave breaking effects can improve model performance and help it to successfully capture the observed upper ocean variability.

Ocean Optics Protocols for Satellite Ocean Color Sensor Validation, Revision 4, Volume IV: Inherent Optical Properties: Instruments, Characterizations, Field Measurements and Data Analysis Protocols

NASA Technical Reports Server (NTRS)

Mueller, J. L.; Fargion, G. S.; McClain, C. R. (Editor); Pegau, S.; Zanefeld, J. R. V.; Mitchell, B. G.; Kahru, M.; Wieland, J.; Stramska, M.

2003-01-01

This document stipulates protocols for measuring bio-optical and radiometric data for the Sensor Intercomparision and Merger for Biological and Interdisciplinary Oceanic Studies (SIMBIOS) Project activities and algorithm development. The document is organized into 6 separate volumes as Ocean Optics Protocols for Satellite Ocean Color Sensor Validation, Revision 4. Volume I: Introduction, Background, and Conventions; Volume II: Instrument Specifications, Characterization and Calibration; Volume III: Radiometric Measurements and Data Analysis Methods; Volume IV: Inherent Optical Properties: Instruments, Characterization, Field Measurements and Data Analysis Protocols; Volume V: Biogeochemical and Bio-Optical Measurements and Data Analysis Methods; Volume VI: Special Topics in Ocean Optics Protocols and Appendices. The earlier version of Ocean Optics Protocols for Satellite Ocean Color Sensor Validation, Revision 3 is entirely superseded by the six volumes of Revision 4 listed above.

Reassessing the Ancient Martian Ocean Hypothesis using Global Distribution of Valley Networks

NASA Astrophysics Data System (ADS)

Chan, Ngai-Ham; Perron, J. Taylor; Mitrovica, Jerry X.

2016-04-01

We re-examine the connection between true polar wander and the Martian ocean hypothesis. Previous studies have investigated the plausibility of an ancient ocean on Mars by examining the ancient putative sea-level markers on the planet's surface. One such study has argued that topographic benches, or contacts, are ancient shorelines, and that these contacts display long-wavelength topographic variations consistent with post-depositional true polar wander (Perron et al., Nature, 2007). In contrast, a second study has argued that the topography of ancient deltaic deposits associated with an ocean on early Mars are not consistent with the true polar wander scenario (Achille & Hynek, Nature Geosci., 2010). We revisit this issue by examining another marker of ancient shorelines --- the fluvial valley networks observed on the surface of Mars. Our results provide further evidence that a true polar wander event drove significant post-depositional deflection of surface features related to an ancient Martian ocean.

Reassessing the Ancient Martian Ocean Hypothesis using Global Distribution of Valley Networks

NASA Astrophysics Data System (ADS)

Chan, N. H.; Perron, J. T.; Mitrovica, J. X.

2015-12-01

We re-examine the connection between true polar wander and the Martian ocean hypothesis. Previous studies have investigated the plausibility of an ancient ocean on Mars by examining the topography of ancient putative sea-level markers on the planet's surface. A previous study has argued that topographic benches, or contacts, are ancient shorelines, and that these contacts display long-wavelength topographic variations consistent with post-depositional true polar wander (Perron et al., Nature, 2007). In contrast, a second study has argued that the topography of ancient deltaic deposits associated with an ocean on early Mars are not consistent with the true polar wander scenario (Achille & Hynek, Nature Geosci., 2010). We revisit this issue by examining another marker of ancient shorelines --- the fluvial valley networks observed on the surface of Mars. Our results provide further evidence that a true polar wander event drove significant post-depositional deflection of surface features related to an ancient Martian ocean.

Weak overturning circulation and increased iron fertilization maximized carbon storage in the glacial ocean

NASA Astrophysics Data System (ADS)

Muglia, J.; Skinner, L.; Schmittner, A.

2017-12-01

Circulation changes have been suggested to play an important role in the sequestration of atmospheric CO2 in the glacial ocean. However, previous studies have resulted in contradictory results regarding the strength of the Atlantic Meridional Overturning Circulation (AMOC) and three-dimensional, quantitative reconstructions of the glacial ocean constrained by multiple proxies remain lacking. Here we simulate the modern and glacial ocean using a coupled, global, three-dimensional, physical-biogeochemical model constrained simultaneously by d13C, radiocarbon, and d15N to explore the effects of AMOC differences and Southern Ocean iron fertilization on the distributions of these isotopes and ocean carbon storage. We show that d13C and radiocarbon data sparsely sampled at the locations of existing glacial sediment cores can be used to reconstruct the modern AMOC accurately. Applying this method to the glacial ocean we find that a surprisingly weak (6-9 Sv or about half of today's) and shallow AMOC maximizes carbon storage and best reproduces the sediment data. Increasing the atmospheric soluble iron flux in the model's Southern Ocean intensifies export production, carbon storage, and improves agreement with d13C and d15N reconstructions. Our best fitting model is a significant improvement compared with previous studies. It suggests that a weak and shallow AMOC and enhanced iron fertilization conspired to maximize carbon storage in the glacial ocean.

Idealised modelling of ocean circulation driven by conductive and hydrothermal fluxes at the seabed

NASA Astrophysics Data System (ADS)

Barnes, Jowan M.; Morales Maqueda, Miguel A.; Polton, Jeff A.; Megann, Alex P.

2018-02-01

Geothermal heating is increasingly recognised as an important factor affecting ocean circulation, with modelling studies suggesting that this heat source could lead to first-order changes in the formation rate of Antarctic Bottom Water, as well as a significant warming effect in the abyssal ocean. Where it has been represented in numerical models, however, the geothermal heat flux into the ocean is generally treated as an entirely conductive flux, despite an estimated one third of the global geothermal flux being introduced to the ocean via hydrothermal sources. A modelling study is presented which investigates the sensitivity of the geothermally forced circulation to the way heat is supplied to the abyssal ocean. An analytical two-dimensional model of the circulation is described, which demonstrates the effects of a volume flux through the ocean bed. A simulation using the NEMO numerical general circulation model in an idealised domain is then used to partition a heat flux between conductive and hydrothermal sources and explicitly test the sensitivity of the circulation to the formulation of the abyssal heat flux. Our simulations suggest that representing the hydrothermal flux as a mass exchange indeed changes the heat distribution in the abyssal ocean, increasing the advective heat transport from the abyss by up to 35% compared to conductive heat sources. Consequently, we suggest that the inclusion of hydrothermal fluxes can be an important addition to course-resolution ocean models.

The frequency response of a coupled ice sheet-ice shelf-ocean system to climate forcing variability

NASA Astrophysics Data System (ADS)

Goldberg, D.; Snow, K.; Jordan, J. R.; Holland, P.; Arthern, R. J.

2017-12-01

Changes at the West Antarctic ice-ocean boundary in recent decades has triggered significant increases in the regions contribution to global sea-level rise, coincident with large scale, and in some cases potentially unstable, grounding line retreat. Much of the induced change is thought to be driven by fluctuations in the oceanic heat available at the ice-ocean boundary, transported on-shelf via warm Circumpolar Deep Water (CDW). However, the processes in which ocean heat drives ice-sheet loss remains poorly understood, with observational studies routinely hindered by the extreme environment notorious to the Antarctic region. In this study we apply a novel synchronous coupled ice-ocean model, developed within the MITgcm, and are thus able to provide detailed insight into the impacts of short time scale (interannual to decadal) climate variability and feedbacks within the ice-ocean system. Feedbacks and response are assessed in an idealised ice-sheet/ocean-cavity configuration in which the far field ocean condition is adjusted to emulate periodic climate variability patterns. We reveal a non-linear response of the ice-sheet to periodic variations in thermocline depth. These non-linearities illustrate the heightened sensitivity of fast flowing ice-shelves to periodic perturbations in heat fluxes occurring at interannual and decadal time scales. The results thus highlight how small perturbations in variable climate forcing, like that of ENSO, may trigger large changes in ice-sheet response.

Seeking a Role for the Ocean and Ocean Scientists in the Future of International Climate Negotiations

NASA Astrophysics Data System (ADS)

Gallo, N.; Eddebbar, Y.; Le, J. T.; Netburn, A. N.; Niles, J. O.; Sato, K.; Wilson, S.; Levin, L. A.

2016-02-01

The oceans cover 71% of the world and are essential to the climate regulation of the planet, but they are severely underrepresented in international climate negotiations. While marine ecosystems were mentioned in the preamble to the United Nations Framework Convention on Climate Change (UNFCCC), they have since been left out of the text of the Kyoto Protocol and the Paris Treaty, and ocean-focused events are lacking at UNFCCC meetings. However, marine ecosystems sustain severe impacts from climate change including warming, acidification, and deoxygenation, and these changes have economic implications for ocean-dependent nations including on tourism, fisheries sustainability, shoreline protection, and human livelihood. Ocean scientists from the Scripps Institution of Oceanography and members of Ocean Scientists for Informed Policy have partnered with the newly-formed Ocean and Climate Platform to raise ocean issues at the UNFCCC meeting in Paris through both official side event presentations within the meeting venue and offsite events for the public. This study focuses on how the role and recognition of the ocean in the UNFCCC negotiations has evolved from COP19 (2013) to COP21 (2015), what may be expected for the role of the ocean in international climate negotiations beyond the Paris Agreement, and addresses what role ocean scientists can play in this conversation.

Seeking a Role for the Ocean and Ocean Scientists in the Future of International Climate Negotiations

NASA Astrophysics Data System (ADS)

Gallo, N.; Eddebbar, Y.; Le, J. T.; Netburn, A. N.; Niles, J. O.; Sato, K.; Wilson, S.; Levin, L. A.

2016-12-01

The oceans cover 71% of the world and are essential to the climate regulation of the planet, but they are severely underrepresented in international climate negotiations. While marine ecosystems were mentioned in the preamble to the United Nations Framework Convention on Climate Change (UNFCCC), they have since been left out of the text of the Kyoto Protocol and the Paris Treaty, and ocean-focused events are lacking at UNFCCC meetings. However, marine ecosystems sustain severe impacts from climate change including warming, acidification, and deoxygenation, and these changes have economic implications for ocean-dependent nations including on tourism, fisheries sustainability, shoreline protection, and human livelihood. Ocean scientists from the Scripps Institution of Oceanography and members of Ocean Scientists for Informed Policy have partnered with the newly-formed Ocean and Climate Platform to raise ocean issues at the UNFCCC meeting in Paris through both official side event presentations within the meeting venue and offsite events for the public. This study focuses on how the role and recognition of the ocean in the UNFCCC negotiations has evolved from COP19 (2013) to COP21 (2015), what may be expected for the role of the ocean in international climate negotiations beyond the Paris Agreement, and addresses what role ocean scientists can play in this conversation.

Primary discussion of a carbon sink in the oceans

NASA Astrophysics Data System (ADS)

Ma, Caihua; You, Kui; Ji, Dechun; Ma, Weiwei; Li, Fengqi

2015-04-01

As a consequence of global warming and rising sea levels, the oceans are becoming a matter of concern for more and more people because these changes will impact the growth of living organisms as well as people's living standards. In particular, it is extremely important that the oceans absorb massive amounts of carbon dioxide. This paper takes a pragmatic approach to analyzing the oceans with respect to the causes of discontinuities in oceanic variables of carbon dioxide sinks. We report on an application of chemical, physical and biological methods to analyze the changes of carbon dioxide in oceans. Based on the relationships among the oceans, land, atmosphere and sediment with respect to carbon dioxide, the foundation of carbon dioxide in shell-building and ocean acidification, the changes in carbon dioxide in the oceans and their impact on climate change, and so on, a vital conclusion can be drawn from this study. Specifically, under the condition that the oceans are not disturbed by external forces, the oceans are a large carbon dioxide sink. The result can also be inferred by the formula: C=A-B and G=E+F when the marine ecosystem can keep a natural balance and the amount of carbon dioxide emission is limited within the carrying capacity of the oceans.

Seafarer citizen scientist ocean transparency data as a resource for phytoplankton and climate research.

PubMed

Seafarers, Secchi Disk; Lavender, Samantha; Beaugrand, Gregory; Outram, Nicholas; Barlow, Nigel; Crotty, David; Evans, Jake; Kirby, Richard

2017-01-01

The oceans' phytoplankton that underpin the marine food chain appear to be changing in abundance due to global climate change. Here, we compare the first four years of data from a citizen science ocean transparency study, conducted by seafarers using home-made Secchi Disks and a free Smartphone application called Secchi, with contemporaneous satellite ocean colour measurements. Our results show seafarers collect useful Secchi Disk measurements of ocean transparency that could help future assessments of climate-induced changes in the phytoplankton when used to extend historical Secchi Disk data.

Use of Multiangle Satellite Observations to Retrieve Aerosol Properties and Ocean Color

NASA Technical Reports Server (NTRS)

Martonchik, John V.; Diner, David; Khan, Ralph

2005-01-01

A new technique is described for retrieving aerosol over ocean water and the associated ocean color using multiangle satellite observations. Unlike current satellite aerosol retrieval algorithms which only utilize observations at red wavelengths and longer, with the assumption that these wavelengths have a negligible ocean (water-leaving radiance), this new algorithm uses all available spectral bands and simultaneously retrieves both aerosol properties and the spectral ocean color. We show some results of case studies using MISR data, performed over different water conditions (coastal water, blooms, and open water).

Oceanic Loading and Local Distortions at the Baksan, Russia, and Gran Sasso, Italy, Strain Stations

NASA Astrophysics Data System (ADS)

Milyukov, V. K.; Amoruso, A.; Crescentini, L.; Mironov, A. P.; Myasnikov, A. V.; Lagutkina, A. V.

2018-03-01

Reliable use of strain data in geophysical studies requires their preliminary correction for ocean loading and various local distortions. These effects, in turn, can be estimated from the tidal records which are contributed by solid and oceanic loading. In this work, we estimate the oceanic tidal loading at two European strain stations (Baksan, Russia, and Gran Sasso, Italy) by analyzing the results obtained with the different Earth and ocean models. The influence of local distortions on the strain measurements at the two stations is estimated.

Oceanic oxygenation events in the anoxic Ediacaran ocean.

PubMed

Sahoo, S K; Planavsky, N J; Jiang, G; Kendall, B; Owens, J D; Wang, X; Shi, X; Anbar, A D; Lyons, T W

2016-09-01

The ocean-atmosphere system is typically envisioned to have gone through a unidirectional oxygenation with significant oxygen increases in the earliest (ca. 635 Ma), middle (ca. 580 Ma), or late (ca. 560 Ma) Ediacaran Period. However, temporally discontinuous geochemical data and the patchy metazoan fossil record have been inadequate to chart the details of Ediacaran ocean oxygenation, raising fundamental debates about the timing of ocean oxygenation, its purported unidirectional rise, and its causal relationship, if any, with the evolution of early animal life. To better understand the Ediacaran ocean redox evolution, we have conducted a multi-proxy paleoredox study of a relatively continuous, deep-water section in South China that was paleogeographically connected with the open ocean. Iron speciation and pyrite morphology indicate locally euxinic (anoxic and sulfidic) environments throughout the Ediacaran in this section. In the same rocks, redox sensitive element enrichments and sulfur isotope data provide evidence for multiple oceanic oxygenation events (OOEs) in a predominantly anoxic global Ediacaran-early Cambrian ocean. This dynamic redox landscape contrasts with a recent view of a redox-static Ediacaran ocean without significant change in oxygen content. The duration of the Ediacaran OOEs may be comparable to those of the oceanic anoxic events (OAEs) in otherwise well-oxygenated Phanerozoic oceans. Anoxic events caused mass extinctions followed by fast recovery in biologically diversified Phanerozoic oceans. In contrast, oxygenation events in otherwise ecologically monotonous anoxic Ediacaran-early Cambrian oceans may have stimulated biotic innovations followed by prolonged evolutionary stasis. © 2016 John Wiley & Sons Ltd.

The National Cancer Institute–American Society of Clinical Oncology Cancer Trial Accrual Symposium: Summary and Recommendations

PubMed Central

Denicoff, Andrea M.; McCaskill-Stevens, Worta; Grubbs, Stephen S.; Bruinooge, Suanna S.; Comis, Robert L.; Devine, Peggy; Dilts, David M.; Duff, Michelle E.; Ford, Jean G.; Joffe, Steven; Schapira, Lidia; Weinfurt, Kevin P.; Michaels, Margo; Raghavan, Derek; Richmond, Ellen S.; Zon, Robin; Albrecht, Terrance L.; Bookman, Michael A.; Dowlati, Afshin; Enos, Rebecca A.; Fouad, Mona N.; Good, Marjorie; Hicks, William J.; Loehrer, Patrick J.; Lyss, Alan P.; Wolff, Steven N.; Wujcik, Debra M.; Meropol, Neal J.

2013-01-01

Introduction: Many challenges to clinical trial accrual exist, resulting in studies with inadequate enrollment and potentially delaying answers to important scientific and clinical questions. Methods: The National Cancer Institute (NCI) and the American Society of Clinical Oncology (ASCO) cosponsored the Cancer Trial Accrual Symposium: Science and Solutions on April 29-30, 2010 to examine the state of accrual science related to patient/community, physician/provider, and site/organizational influences, and identify new interventions to facilitate clinical trial enrollment. The symposium featured breakout sessions, plenary sessions, and a poster session including 100 abstracts. Among the 358 attendees were clinical investigators, researchers of accrual strategies, research administrators, nurses, research coordinators, patient advocates, and educators. A bibliography of the accrual literature in these three major areas was provided to participants in advance of the meeting. After the symposium, the literature in these areas was revisited to determine if the symposium recommendations remained relevant within the context of the current literature. Results: Few rigorously conducted studies have tested interventions to address challenges to clinical trials accrual. Attendees developed recommendations for improving accrual and identified priority areas for future accrual research at the patient/community, physician/provider, and site/organizational levels. Current literature continues to support the symposium recommendations. Conclusions: A combination of approaches addressing both the multifactorial nature of accrual challenges and the characteristics of the target population may be needed to improve accrual to cancer clinical trials. Recommendations for best practices and for future research developed from the symposium are provided. PMID:24130252

Understanding the role of physician assistants in oncology.

PubMed

Ross, Alicia C; Polansky, Maura N; Parker, Patricia A; Palmer, J Lynn

2010-01-01

To understand the deployment of physician assistants (PAs) in oncology. A recent analysis of the oncology workforce in the United States commissioned by ASCO predicted a significant shortage of providers by 2020. A descriptive study was undertaken using a Web-based questionnaire survey. Invited participants, including all PAs listed in the national PA database (n = 855) and all PAs at The University of Texas M. D. Anderson Cancer Center (Houston, TX; n = 159), were mailed letters directing them to the Web-based survey. The study produced a 30% response rate. A total of 186 PAs worked in medical oncology (the population of interest). Of the respondents, 80% were women, mean age was 36 years, average time employed as a PA was 9.5 years (6.5 years in oncology), 55% had obtained a master's degree, four had completed a postgraduate oncology program, 91% reported that direct mentorship by a supervising physician was very important in obtaining oncology-based knowledge, and 61% reported that becoming fully competent in the practice of oncology required 1 to 2 years. The majority of PAs (78.5%) worked 33 to 50 hours per week, and 56% of those reported working 41 to 50 hours per week. Three fourths (77%) wrote chemotherapy orders, most requiring physician co-signature, and 69% prescribed schedule III to V controlled substances. Additional data were gathered regarding clinical duties, research, and teaching. Oncology PAs are used in multiple medical settings, and many assume high-level responsibilities. Future research addressing function and factors that limit use of PAs may allow for improved organizational efficiency and enhancement in the delivery of health care.

Strategies to overcome clinical, regulatory, and financial challenges in the implementation of personalized medicine.

PubMed

Tsimberidou, Apostolia M; Ringborg, Ulrik; Schilsky, Richard L

2013-01-01

This article highlights major developments over the last decade in personalized medicine in cancer. Emerging data from clinical studies demonstrate that the use of targeted agents in patients with targetable molecular aberrations improves clinical outcomes. Despite a surge of studies, however, significant gaps in knowledge remain, especially in identifying driver molecular aberrations in patients with multiple aberrations, understanding molecular networks that control carcinogenesis and metastasis, and most importantly, discovering effective targeted agents. Implementation of personalized medicine requires continued scientific and technological breakthroughs; standardization of tumor tissue acquisition and molecular testing; changes in oncology practice and regulatory standards for drug and device access and approval; modification of reimbursement policies by health care payers; and innovative ways to collect and analyze electronic patient information that are linked to prospective clinical registries and rapid learning systems. Informatics systems that integrate clinical, laboratory, radiologic, molecular, and economic data will improve clinical care and will provide infrastructure to enable clinical research. The initiative of the EurocanPlatform aims to overcome the challenges of implementing personalized medicine in Europe by sharing patients, biologic materials, and technological resources across borders. The EurocanPlatform establishes a complete translational cancer research program covering the drug development process and strengthening collaborations among academic centers, pharmaceutical companies, regulatory authorities, health technology assessment organizations, and health care systems. The CancerLinQ rapid learning system being developed by ASCO has the potential to revolutionize how all stakeholders in the cancer community assemble and use information obtained from patients treated in real-world settings to guide clinical practice, regulatory decisions, and health care payment policy.

Insights into the crustal structure of the transition between Nares Strait and Baffin Bay

NASA Astrophysics Data System (ADS)

Altenbernd, Tabea; Jokat, Wilfried; Heyde, Ingo; Damm, Volkmar

2016-11-01

The crustal structure and continental margin between southern Nares Strait and northern Baffin Bay were studied based on seismic refraction and gravity data acquired in 2010. We present the resulting P wave velocity, density and geological models of the crustal structure of a profile, which extends from the Greenlandic margin of the Nares Strait into the deep basin of central northern Baffin Bay. For the first time, the crustal structure of the continent-ocean transition of the very northern part of Baffin Bay could be imaged. We divide the profile into three parts: continental, thin oceanic, and transitional crust. On top of the three-layered continental crust, a low-velocity zone characterizes the lowermost layer of the three-layered Thule Supergroup underneath Steensby Basin. The 4.3-6.3 km thick oceanic crust in the southern part of the profile can be divided into a northern and southern section, more or less separated by a fracture zone. The oceanic crust adjacent to the continent-ocean transition is composed of 3 layers and characterized by oceanic layer 3 velocities of 6.7-7.3 km/s. Toward the south only two oceanic crustal layers are necessary to model the travel time curves. Here, the lower oceanic crust has lower seismic velocities (6.4-6.8 km/s) than in the north. Rather low velocities of 7.7 km/s characterize the upper mantle underneath the oceanic crust, which we interpret as an indication for the presence of upper mantle serpentinization. In the continent-ocean transition zone, the velocities are lower than in the adjacent continental and oceanic crustal units. There are no signs for massive magmatism or the existence of a transform margin in our study area.

Salinity Processes in the Upper Ocean Regional Study (SPURS)

NASA Image and Video Library

2012-09-05

A sensor-laden buoy is lifted onboard the Woods Hole Oceanographic Institution's research vessel Knorr on wednesday, Sept. 5, 2012, in Woods Hole, Mass. The buoy will be deployed in the Atlantic Ocean as part of the Salinity Processes in the Upper Ocean Regional Study (SPURS) which is set to sail on Sept. 6. The NASA-sponsored expedition will sail to the North Atlantic's saltiest spot to get a detailed, 3-D picture of how salt content fluctuates in the ocean's upper layers and how these variations are related to shifts in rainfall patterns around the planet. Photo Credit: (NASA/Bill Ingalls)

New perspectives in ocean acidification research: editor's introduction to the special feature on ocean acidification.

PubMed

Munday, Philip L

2017-09-01

Ocean acidification, caused by the uptake of additional carbon dioxide (CO 2 ) from the atmosphere, will have far-reaching impacts on marine ecosystems (Gattuso & Hansson 2011 Ocean acidification Oxford University Press). The predicted changes in ocean chemistry will affect whole biological communities and will occur within the context of global warming and other anthropogenic stressors; yet much of the biological research conducted to date has tested the short-term responses of single species to ocean acidification conditions alone. While an important starting point, these studies may have limited predictive power because they do not account for possible interactive effects of multiple climate change drivers or for ecological interactions with other species. Furthermore, few studies have considered variation in responses among populations or the evolutionary potential within populations. Therefore, our knowledge about the potential for marine organisms to adapt to ocean acidification is extremely limited. In 2015, two of the pioneers in the field, Ulf Riebesell and Jean-Pierre Gattuso, noted that to move forward as a field of study, future research needed to address critical knowledge gaps in three major areas: (i) multiple environmental drivers, (ii) ecological interactions and (iii) acclimation and adaptation (Riebesell and Gattuso 2015 Nat. Clim. Change 5 , 12-14 (doi:10.1038/nclimate2456)). In May 2016, more than 350 researchers, students and stakeholders met at the 4th International Symposium on the Ocean in a High-CO 2 World in Hobart, Tasmania, to discuss the latest advances in understanding ocean acidification and its biological consequences. Many of the papers presented at the symposium reflected this shift in focus from short-term, single species and single stressor experiments towards multi-stressor and multispecies experiments that address knowledge gaps about the ecological impacts of ocean acidification on marine communities. The nine papers in this Special Feature are from authors who attended the symposium and address cutting-edge questions and emerging topics in ocean acidification research, across the taxonomic spectrum from plankton to top predators. They cover the three streams of research identified as crucial to understanding the biological impacts of ocean acidification: (i) the relationship with other environmental drivers, (ii) the effects on ecological process and species interactions, and (iii) the role that individual variation, phenotypic plasticity and adaptation will have in shaping the impacts of ocean acidification and warming on marine ecosystems. © 2017 The Author(s).

Multimillennium changes in dissolved oxygen under global warming: results from an AOGCM and offline ocean biogeochemical model

NASA Astrophysics Data System (ADS)

Yamamoto, A.; Abe-Ouchi, A.; Shigemitsu, M.; Oka, A.; Takahashi, K.; Ohgaito, R.; Yamanaka, Y.

2016-12-01

Long-term oceanic oxygen change due to global warming is still unclear; most future projections (such as CMIP5) are only performed until 2100. Indeed, few previous studies using conceptual models project oxygen change in the next thousands of years, showing persistent global oxygen reduction by about 30% in the next 2000 years, even after atmospheric carbon dioxide stops rising. Yet, these models cannot sufficiently represent the ocean circulation change: the key driver of oxygen change. Moreover, considering serious effect oxygen reduction has on marine life and biogeochemical cycling, long-term oxygen change should be projected for higher validity. Therefore, we used a coupled atmosphere-ocean general circulation model (AOGCM) and an offline ocean biogeochemical model, investigating realistic long-term changes in oceanic oxygen concentration and ocean circulation. We integrated these models for 2000 years under atmospheric CO2 doubling and quadrupling. After global oxygen reduction in the first 500 years, oxygen concentration in deep ocean globally recovers and overshoots, despite surface oxygen decrease and weaker Atlantic Meridional Overturning Circulation. Deep ocean convection in the Weddell Sea recovers and overshoots, after initial cessation. Thus, enhanced deep convection and associated Antarctic Bottom Water supply oxygen-rich surface waters to deep ocean, resulting global deep ocean oxygenation. We conclude that the change in ocean circulation in the Southern Ocean potentially drives millennial-scale oxygenation in the deep ocean; contrary to past reported long-term oxygen reduction and general expectation. In presentation, we will discuss the mechanism of response of deep ocean convection in the Weddell Sea and show the volume changes of hypoxic waters.

The Living Ocean.

ERIC Educational Resources Information Center

National Aeronautics and Space Administration, Washington, DC.

This teaching guide contains information, activities, and discussion questions and answers about oceans for grades nine and ten. The information section covers the following topics: studying global ocean color from space, what can be seen from space, phytoplankton, carbon dioxide, and the greenhouse effect of the earth. (MKR)

Disciplinary reporting affects the interpretation of climate change impacts in global oceans.

PubMed

Hauser, Donna D W; Tobin, Elizabeth D; Feifel, Kirsten M; Shah, Vega; Pietri, Diana M

2016-01-01

Climate change is affecting marine ecosystems, but different investigative approaches in physical, chemical, and biological disciplines may influence interpretations of climate-driven changes in the ocean. Here, we review the ocean change literature from 2007 to 2012 based on 461 of the most highly cited studies in physical and chemical oceanography and three biological subdisciplines. Using highly cited studies, we focus on research that has shaped recent discourse on climate-driven ocean change. Our review identified significant differences in spatial and temporal scales of investigation among disciplines. Physical/chemical studies had a median duration of 29 years (n = 150) and covered the greatest study areas (median 1.41 × 10(7) km(2) , n = 148). Few biological studies were conducted over similar spatial and temporal scales (median 8 years, n = 215; median 302 km(2) , n = 196), suggesting a more limited ability to separate climate-related responses from natural variability. We linked physical/chemical and biological disciplines by tracking studies examining biological responses to changing ocean conditions. Of the 545 biological responses recorded, a single physical or chemical stressor was usually implicated as the cause (59%), with temperature as the most common primary stressor (44%). The most frequently studied biological responses were changes in physiology (31%) and population abundance (30%). Differences in disciplinary studies, as identified in this review, can ultimately influence how researchers interpret climate-related impacts in marine systems. We identified research gaps and the need for more discourse in (1) the Indian and other Southern Hemisphere ocean basins; (2) research themes such as archaea, bacteria, viruses, mangroves, turtles, and ocean acidification; (3) physical and chemical stressors such as dissolved oxygen, salinity, and upwelling; and (4) adaptive responses of marine organisms to climate-driven ocean change. Our findings reveal that highly cited biological studies are rarely conducted on scales that match those of physical and chemical studies. Rather, we suggest a need for measuring responses at biologically relevant scales. © 2015 The Authors. Global Change Biology Published by John Wiley & Sons Ltd.

Overview of the Frontal Air-Sea Interaction Experiment (FASINEX) - A study of air-sea interaction in a region of strong oceanic gradients

NASA Technical Reports Server (NTRS)

Weller, Robert A.

1991-01-01

From 1984 to 1986 the cooperative Frontal Air-Sea Interaction Experiment (FASINEX) was conducted in the subtropical convergence zone southwest of Bermuda. The overall objective of the experiment was to study air-sea interaction on 1- to 100-km horizontal scales in a region of the open ocean characterized by strong horizontal gradients in upper ocean and sea surface properties. Ocean fronts provided both large spatial gradients in sea surface temperature and strong jetlike flows in the upper ocean. The motivation for and detailed objectives of FASINEX are reviewed. Then the components of the field program are summarized. Finally, selected results are presented in order to provide an overview of the outcome of FASINEX.

Ocean studies board has new chairman

NASA Astrophysics Data System (ADS)

Katsouros, Mary Hope

John Sclater of the University of Texas at Austin has succeeded Walter Munk as chairman of the National Research Council's Ocean Studies Board. His term runs to June 30, 1991. The 17 members of OSB represent major disciplines in oceanography. The board advises the academic community and agencies of the federal government responsible for funding basic and applied research in oceanography and for maintaining the wellbeing of the oceans.

What Is Physical Oceanography? A Learning Experience for Coastal and Oceanic Awareness Studies, No. 217. [Project COAST].

ERIC Educational Resources Information Center

Delaware Univ., Newark. Coll. of Education.

This unit is concerned with an overview of physical oceanography - the study of currents, tides, waves, and particle movements. The activities are designed for use by junior high school age students. Included in the unit are activities related to properties of sea water, physical phenomena of the ocean, and physical features of the ocean.…

Accelerated Prediction of the Polar Ice and Global Ocean (APPIGO)

DTIC Science & Technology

2014-09-30

APPIGO) Eric Chassignet Center for Ocean-Atmosphere Prediction Studies (COAPS) Florida State University PO Box 3062840 Tallahassee, FL 32306...PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Florida Atlantic University,Center for Ocean-Atmosphere Prediction Studies (COAPS),PO Box 3062840...Cavalieri, D. J., C. I. Parkinson , P. Gloersen, and H. J. Zwally. 1997. Arctic and Antarctic Sea Ice Concentrations from Multichannel Passive-Microwave

World Ocean Database and the Global Temperature and Salinity Profile Program Database: Synthesis of historical and near real-time ocean profile data

NASA Astrophysics Data System (ADS)

Boyer, T.; Sun, L.; Locarnini, R. A.; Mishonov, A. V.; Hall, N.; Ouellet, M.

2016-02-01

The World Ocean Database (WOD) contains systematically quality controlled historical and recent ocean profile data (temperature, salinity, oxygen, nutrients, carbon cycle variables, biological variables) ranging from Captain Cooks second voyage (1773) to this year's Argo floats. The US National Centers for Environmental Information (NCEI) also hosts the Global Temperature and Salinity Profile Program (GTSPP) Continuously Managed Database (CMD) which provides quality controlled near-real time ocean profile data and higher level quality controlled temperature and salinity profiles from 1990 to present. Both databases are used extensively for ocean and climate studies. Synchronization of these two databases will allow easier access and use of comprehensive regional and global ocean profile data sets for ocean and climate studies. Synchronizing consists of two distinct phases: 1) a retrospective comparison of data in WOD and GTSPP to ensure that the most comprehensive and highest quality data set is available to researchers without the need to individually combine and contrast the two datasets and 2) web services to allow the constantly accruing near-real time data in the GTSPP CMD and the continuous addition and quality control of historical data in WOD to be made available to researchers together, seamlessly.

Comparative Analysis of Lipid Content and Fatty Acid Composition of Commercially Important Fish and Shellfish from Sri Lanka and Japan.

PubMed

Devadason, Chandravathany; Jayasinghe, Chamila; Sivakanesan, Ramiah; Senarath, Samanthika; Beppu, Fumiaki; Gotoh, Naohiro

2016-01-01

Sri Lanka is surrounded by the Indian Ocean, allowing plenty of fishes to be caught. Moreover, these fishes represent one of the undocumented fish resources in the world and their detailed lipid profiles have not been previously examined. In this study, the lipid content and fatty acid composition of 50 commercially important fishes from the Indian Ocean (Sri Lanka) and the Pacific Ocean (Japan) were compared. The total lipid content and fatty acid composition, including eicosapentaenoic acid (C20:5n-3, EPA) and docosahexaenoic acid (C22:6n-3, DHA), differed significantly among species. Fish from the Pacific Ocean had higher proportions of fatty acids, including EPA and DHA. Herrings and mackerels from both oceanic areas demonstrated high levels of EPA and DHA, and n-3/n-6 ratio. Brackish and freshwater fishes from both groups showed low levels of PUFAs. Fish from the Indian Ocean were high in n-6 fatty acids. Monounsaturated fatty acid levels were high in omnivorous fish from the Pacific Ocean, and saturated fatty acid levels were high in fish from the Indian Ocean. The results of this study will be of value in determining the dietary usefulness of fish caught in Sri Lanka.

Transient rheology of the oceanic asthenosphere following the 2012 Indian Ocean Earthquake inferred from geodetic data

NASA Astrophysics Data System (ADS)

Pratama, Cecep; Ito, Takeo; Sasajima, Ryohei; Tabei, Takao; Kimata, Fumiaki; Gunawan, Endra; Ohta, Yusaku; Yamashina, Tadashi; Ismail, Nazli; Nurdin, Irwandi; Sugiyanto, Didik; Muksin, Umar; Meilano, Irwan

2017-10-01

Postseismic motion in the middle-field (100-500 km from the epicenter) geodetic data resulting from the 2012 Indian Ocean earthquake exhibited rapid change during the two months following the rupture. This pattern probably indicates multiple postseismic deformation mechanisms and might have been controlled by transient rheology. Therefore, the relative contribution of transient rheology in the oceanic asthenosphere and afterslip in the oceanic lithosphere should be incorporated to explain short- and long-term transitional features of postseismic signals. In this study, using two years of post-earthquake geodetic data from northern Sumatra, a three-dimensional spherical-earth finite-element model was constructed based on a heterogeneous structure and incorporating transient rheology. A rheology model combined with stress-driven afterslip was estimated. Our best-fit model suggests an oceanic lithosphere thickness of 75 km with oceanic asthenosphere viscosity values of 1 × 1017 Pa s and 2 × 1018 Pa s for the Kelvin and Maxwell viscosity models, respectively. The model results indicate that horizontal landward motion and vertical uplift in northern Sumatra require viscoelastic relaxation of the oceanic asthenosphere coupled with afterslip in the lithosphere. The present study demonstrates that transient rheology is essential for reproducing the rapidly changing motion of postseismic deformation in the middle-field area.

Autonomous Observational Platforms for Ocean Studies: Operation, Advantages of Sensor Technology and Data Management

NASA Astrophysics Data System (ADS)

Atamanchuk, D.; Lai, J.; Vining, M.; Kehoe, D.; Siddall, G.; Send, U.; Wallace, D.

2016-02-01

Ocean Science and Technology research group (CERC.OCEAN) at Dalhousie University focuses on new approaches in design and development of autonomous platforms to study biogeochemical and ecological changes in the world's oceans. The principal research regions included the Labrador Sea, the Northwest Atlantic between Halifax and Bermuda, and the coastal areas of Atlantic Canada. The need for improved constraints on the ocean's present and future carbon cycle is of high relevance for the Northwest Atlantic, which is recognized as a largest sink of carbon dioxide(CO2) through air-sea exchange and subsequent transport to deeper layers of the global ocean. With the use of novel sensor technology integrated into the designed platforms we are achieving a superior spatial and temporal resolution of observations. SeaCycler - a surface piercing mooring - was designed to endure year-long measurements in harsh conditions of the open ocean, like Labrador Sea, while making daily profiles of the upper 150m of the water column. Significant research efforts within CERC.OCEAN are dedicated for improving sensors' data outcome. This includes testing, calibration of the sensors, QC and postprocessing to assure reliable and trustworthy measurements. Examples and implication of the data from SeaCycler, and other platforms including buoys, and automonous Volunteer Observing Ship (VOS) flow-through system will be presented.

SEASAT economic assessment. Volume 4: Ocean mining case study and generalization. [economic benefits of SEASAT satellites for mineral exploration

NASA Technical Reports Server (NTRS)

1975-01-01

The results of a study of the weather sensitive features of near shore and deep water ocean mining industries are described. Problems with the evaluation of economic benefits for the deep water ocean mining industry are attributed to the relative immaturity and highly proprietary nature of the industry. Case studies on the gold industry, diamond industry, tin industry and sand and gravel industry are cited.

Warming and surface ocean acidification over the last deglaciation: implications for foraminiferal assemblages

NASA Astrophysics Data System (ADS)

Dyez, K. A.; Hoenisch, B.; deMenocal, P. B.

2017-12-01

Although plankton drift with ocean currents, their presence and relative abundance varies across latitudes and environmental seawater conditions (e.g. temperature, pH, salinity). While earlier studies have focused on temperature as the primary factor for determining the regional species composition of planktic foraminiferal communities, evidence has recently been presented that foraminiferal shell thickness varies with ocean pH, and it remains unclear whether ongoing ocean acidification will cause ecological shifts within this plankton group. The transition from the last glacial maximum (LGM; 19,000-23,000 years B.P.) to the late Holocene (0-5,000 years B.P.) was characterized by both warming and acidification of the surface ocean, and thus provides an opportunity to study ecosystem shifts in response to these environmental changes. Here we provide new δ11B, Mg/Ca, and δ18O measurements from a suite of global sediment cores spanning this time range. We use these geochemical data to reconstruct ocean temperature, pH and salinity and pair the new data with previously published analyses of planktic foraminifera assemblages to study the respective effects of ocean warming and acidification on the foraminiferal habitat. At most open-ocean sample locations, our proxies indicate warming and acidification similar to previously published estimates, but in some marginal seas and coastal locations pH changes little between over the glacial termination. At face value, these observations suggest that warming is generally more important for ecosystem changes than acidification, at least over the slow rates of warming and ocean acidification in this time period. While geochemical data collection is being completed, we aim to include these data in an ecological model of foraminiferal habitat preferences.

Ocean-Atmosphere Coupled Model Simulations of Precipitation in the Central Andes

NASA Technical Reports Server (NTRS)

Nicholls, Stephen D.; Mohr, Karen I.

2015-01-01

The meridional extent and complex orography of the South American continent contributes to a wide diversity of climate regimes ranging from hyper-arid deserts to tropical rainforests to sub-polar highland regions. In addition, South American meteorology and climate are also made further complicated by ENSO, a powerful coupled ocean-atmosphere phenomenon. Modelling studies in this region have typically resorted to either atmospheric mesoscale or atmosphere-ocean coupled global climate models. The latter offers full physics and high spatial resolution, but it is computationally inefficient typically lack an interactive ocean, whereas the former offers high computational efficiency and ocean-atmosphere coupling, but it lacks adequate spatial and temporal resolution to adequate resolve the complex orography and explicitly simulate precipitation. Explicit simulation of precipitation is vital in the Central Andes where rainfall rates are light (0.5-5 mm hr-1), there is strong seasonality, and most precipitation is associated with weak mesoscale-organized convection. Recent increases in both computational power and model development have led to the advent of coupled ocean-atmosphere mesoscale models for both weather and climate study applications. These modelling systems, while computationally expensive, include two-way ocean-atmosphere coupling, high resolution, and explicit simulation of precipitation. In this study, we use the Coupled Ocean-Atmosphere-Wave-Sediment Transport (COAWST), a fully-coupled mesoscale atmosphere-ocean modeling system. Previous work has shown COAWST to reasonably simulate the entire 2003-2004 wet season (Dec-Feb) as validated against both satellite and model analysis data when ECMWF interim analysis data were used for boundary conditions on a 27-9-km grid configuration (Outer grid extent: 60.4S to 17.7N and 118.6W to 17.4W).

Ocean Model Impact Study for Coupled Hurricane Forecasting: An HFIP Initiative

NASA Astrophysics Data System (ADS)

Kim, H. S. S.; Halliwell, G. R., Jr.; Tallapragada, V.; Black, P. G.; Bond, N.; Chen, S.; Cione, J.; Cronin, M. F.; Ginis, I.; Liu, B.; Miller, L.; Jayne, S. R.; Sanabia, E.; Shay, L. K.; Uhlhorn, E.; Zhu, L.

2016-02-01

Established in 2009, the NOAA Hurricane Forecast Improvement Project (HFIP) is a ten-year project to promote accelerated improvements hurricane track and intensity forecasts (Gall et al. 2013). The Ocean Model Impact Tiger Team (OMITT) consisting of model developers and research scientists was formed as one of HFIP working groups in December 2014, to evaluate the impact of ocean coupling in tropical cyclone (TC) forecasts. The team investigated the ocean model impact in real cases for Category 3 Hurricane Edouard in 2014, using simulations and observations that were collected for different stages of the hurricane. Two Eastern North Pacific Hurricanes in 2015, Blanca and Dolores, are also of special interest. These two powerful Category 4 storms followed a similar track, however, they produced dramatically different ocean cooling, about 7.2oC for Hurricane Blanca but only about 2.7oC for Hurricane Dolores, and the corresponding intensity changes were negative 40 ms-1 and 20 ms-1, respectively. Two versions of operational HWRF and COAMPS-TC coupled prediction systems are employed in the study. These systems are configured to have 1D and 3D ocean dynamics coupled to the atmosphere. The ocean components are initialized separately with climatology, analysis and nowcast products to evaluate the impact of ocean initialization on hurricane forecasts. Real storm forecast experiments are being designed and performed with different levels of the ocean model complexity and various model configurations to study model sensitivity. In this talk, we report the OMITT activities conducted during the past year, present preliminary results of on-going investigation of air-sea interactions in the simulations, and discuss future plans toward improving coupled TC predictions. Gall, R., J. Franklin, F. Marks, E.N. Rappaport, and F. Toepfer, 2013: THE HURRICANE FORECAST IMPROVEMENT PROJECT. Bull. Amer. Meteor. Soc., 329-343.

Interaction between Coastal and Oceanic Ecosystems of the Western and Central Pacific Ocean through Predator-Prey Relationship Studies

PubMed Central

Allain, Valerie; Fernandez, Emilie; Hoyle, Simon D.; Caillot, Sylvain; Jurado-Molina, Jesus; Andréfouët, Serge; Nicol, Simon J.

2012-01-01

The Western and Central Pacific Ocean sustains the highest tuna production in the world. This province is also characterized by many islands and a complex bathymetry that induces specific current circulation patterns with the potential to create a high degree of interaction between coastal and oceanic ecosystems. Based on a large dataset of oceanic predator stomach contents, our study used generalized linear models to explore the coastal-oceanic system interaction by analyzing predator-prey relationship. We show that reef organisms are a frequent prey of oceanic predators. Predator species such as albacore (Thunnus alalunga) and yellowfin tuna (Thunnus albacares) frequently consume reef prey with higher probability of consumption closer to land and in the western part of the Pacific Ocean. For surface-caught-predators consuming reef prey, this prey type represents about one third of the diet of predators smaller than 50 cm. The proportion decreases with increasing fish size. For predators caught at depth and consuming reef prey, the proportion varies with predator species but generally represents less than 10%. The annual consumption of reef prey by the yellowfin tuna population was estimated at 0.8±0.40CV million tonnes or 2.17×1012±0.40CV individuals. This represents 6.1%±0.17CV in weight of their diet. Our analyses identify some of the patterns of coastal-oceanic ecosystem interactions at a large scale and provides an estimate of annual consumption of reef prey by oceanic predators. PMID:22615796

Air-Sea Momentum and Enthalpy Exchange in Coupled Atmosphere-Wave-Ocean Modeling of Tropical Cyclones

NASA Astrophysics Data System (ADS)

Curcic, M.; Chen, S. S.

2016-02-01

The atmosphere and ocean are coupled through momentum, enthalpy, and mass fluxes. Accurate representation of these fluxes in a wide range of weather and climate conditions is one of major challenges in prediction models. Their current parameterizations are based on sparse observations in low-to-moderate winds and are not suited for high wind conditions such as tropical cyclones (TCs) and winter storms. In this study, we use the Unified Wave INterface - Coupled Model (UWIN-CM), a high resolution, fully-coupled atmosphere-wave-ocean model, to better understand the role of ocean surface waves in mediating air-sea momentum and enthalpy exchange in TCs. In particular, we focus on the explicit treatment of wave growth and dissipation for calculating atmospheric and oceanic stress, and its role in upper ocean mixing and surface cooling in the wake of the storm. Wind-wave misalignment and local wave disequilibrium result in difference between atmospheric and oceanic stress being largest on the left side of the storm. We find that explicit wave calculation in the coupled model reduces momentum transfer into the ocean by more than 10% on average, resulting in reduced cooling in TC's wake and subsequent weakening of the storm. We also investigate the impacts of sea surface temperature and upper ocean parameterization on air-sea enthalpy fluxes in the fully coupled model. High-resolution UWIN-CM simulations of TCs with various intensities and structure are conducted in this study to better understand the complex TC-ocean interaction and improve the representation of air-sea coupling processes in coupled prediction models.

Assimilation of TOPEX/POSEIDON Altimeter Data into a Global Ocean Circulation Model: Are the Results Any Good?

NASA Technical Reports Server (NTRS)

Fukumori, I.; Fu, L. L.; Chao, Y.

1998-01-01

The feasibility of assimilating satellite altimetry data into a global ocean general ocean general circulation model is studied. Three years of TOPEX/POSEIDON data is analyzed using a global, three-dimensional, nonlinear primitive equation model.

Environmental programs for ocean thermal energy conversion (OTEC)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilde, P.

1981-07-01

The environmental research effort in support of the US Department of Energy's Ocean Thermal Energy Conversion (OTEC) program has the goal of providing documented information on the effect of proposed operations on the ocean and the effect of oceanic conditions on the plant. The associated environment program consists of archival studies in potential areas serial oceanographic cruises to sites or regions of interest, studies from various fixed platforms at sites, and compilation of such information for appropriate legal compliance and permit requirements and for use in progressive design of OTEC plants. Site/regions investigated are south of Mobile and west ofmore » Tampa, Gulf of Mexico; Punta Tuna, Puerto Rico; St. Croix, Virgin Islands; Kahe Point, Oahu and Keahole Point, Hawaii, Hawaiian Islands; and off the Brazilian south Equatorial Coast. Four classes of environmental concerns identified are: redistribution of oceanic properties (ocean water mixing, impingement/entrainment etc.); chemical pollution (biocides, working fluid leaks, etc.); structural effects (artificial reef, aggregation, nesting/migration, etc.); socio-legal-economic (worker safety, enviromaritime law, etc.).« less

Relation of laboratory and remotely sensed spectral signatures of ocean-dumped acid waste

NASA Technical Reports Server (NTRS)

Lewis, B. W.

1978-01-01

Results of laboratory transmission and remotely sensed ocean upwelled spectral signatures of acid waste ocean water solutions are presented. The studies were performed to establish ocean-dumped acid waste spectral signatures and to relate them to chemical and physical interactions occurring in the dump plume. The remotely sensed field measurements and the laboratory measurements were made using the same rapid-scanning spectrometer viewing a dump plume and with actual acid waste and ocean water samples, respectively. Laboratory studies showed that the signatures were produced by soluble ferric iron being precipitated in situ as ferric hydroxide upon dilution with ocean water. Sea-truth water samples were taken and analyzed for pertinent major components of the acid waste. Relationships were developed between the field and laboratory data both for spectral signatures and color changes with concentration. The relationships allow for the estimation of concentration of the indicator iron from remotely sensed spectral data and the laboratory transmission concentration data without sea-truth samples.

Strategies for reducing ocean plastic debris should be diverse and guided by science

NASA Astrophysics Data System (ADS)

Rochman, Chelsea M.

2016-04-01

Studies suggest that trillions of microplastic particles are floating on the surface of the global oceans and that the total amount of plastic waste entering the ocean will increase by an order of magnitude by 2025. As such, this ever-increasing problem demands immediate mitigation and reduction. Diverse solutions have been proposed, ranging from source reduction to ocean-based cleanup. These solutions are most effective when guided by scientific evidence. A study published in Environmental Research Letters (Sherman and van Sebille 2016 Environ. Res. Lett. 11 014006) took a closer look at the potential effectiveness of ocean-based cleanup. They conclude that it will be most cost-effective and ecologically beneficial if clean-up efforts focus on the flux of microplastics from the coasts rather than in the center of the oceans where plastic accumulates in so called ‘garbage patches’. If followed, this example may become one of a series of examples where science has informed a solution to the complex problem of plastic pollution.

Review and status of sonic boom penetration into the ocean.

PubMed

Sparrow, Victor W

2002-01-01

Since the 1970 Sonic Boom Symposium, held at the ASA's 80th meeting in Houston, TX, substantial progress has been made in understanding the penetration of sonic booms into the ocean. The state of the art at that time was documented by J. C. Cook, T. Goforth, and R. K. Cook [J. Acoust. Soc. Am. 51, 729-741 (1972)]. Since then, additional experiments have been performed which corroborate Cook's and Sawyers' theory for sonic boom penetration into a flat ocean surface. In addition, computational simulations have validated that theory and extended the work to include arbitrarily shaped waveforms penetrating flat ocean surfaces. Further numerical studies have investigated realistic ocean surfaces including large-scale ocean swell. Research has also been performed on the effects of ocean inhomogeneities due to bubble plumes. This paper provides a brief overview of these developments.

Dust and Ocean Plants

NASA Technical Reports Server (NTRS)

2002-01-01

Adding iron to the diet of marine plant life has been shown in shipboard experiments to boost the amount of carbon-absorbing phytoplankton in certain parts of the world's oceans. A new study promises to give scientists their first global picture of the extent of these unique 'iron-limited' ocean regions, an important step in understanding how the ocean's biology controls the flow of carbon between the atmosphere and the ocean. The new study by researchers at NASA's Goddard Space Flight Center and the Department of Energy's Oak Ridge National Laboratory was presented at the American Geophysical Union's annual meeting in San Francisco on Friday, Dec. 15, 2000. Oceanic phytoplankton remove nearly as much carbon from the atmosphere each year as all land-based plants. Identifying the location and size of nutrient-limited areas in the open ocean has challenged oceanographers for nearly a century. The study pinpointed iron-limited regions by seeing which phytoplankton-rich areas of the world's oceans were also areas that received iron from wind-blown dust. In this map, areas with high levels of chlorophyll from phytoplankton and high levels of dust deposition (high correlation coefficients) are indicated in dark brown. Dust deposition was calculated by a 3-year modelled climatology for the years 1996-1998. The chlorophyll measurements are from 1998 observations from the SeaWiFS (Sea-viewing Wide Field-of-view Sensor) instrument on the OrbView-2 satellite. 'Global, satellite-based analyses such as this gives us insight into where iron deposition may be limiting ocean biological activity,' says lead author David Erickson of Oak Ridge National Laboratory's Computer Science and Mathematics Division. 'With this information we will be able to infer how the ocean productivity/iron deposition relationship might shift in response to climate change.' Map Source: David Erickson, Oak Ridge National Laboratory's Computer Science and Mathematics Division

Understanding the recent changes in the Southern Ocean carbon cycle: A multidisciplinary approach

NASA Astrophysics Data System (ADS)

Manizza, M.; Kahru, M.; Menemenlis, D.; Nevison, C. D.; Mitchell, B. G.; Keeling, R. F.

2016-12-01

The Southern Ocean represents a key area of the global ocean for the uptake of the CO2 originating from fossil fuels emissions. In these waters, cold temperatures combined with high rates of biological production drive the carbon uptake that accounts for about one-third of the global ocean uptake.Recent studies showed that changes in the Southern Annular Mode (SAM) index, mainly a proxy of the intensity of westerly winds, had a significant impact on the temporal variability of the CO2 uptake in the Southern Ocean. In order to shed light on this problem we propose to use both satellite-derived estimates of ocean productivity and carbon export in combinations of ocean physical and biogeochemical state estimates focusing on the 2006-2013 period. While the estimates of carbon fixation and export based on remote sensing will provide key information on the spatial and temporal variations of the biological carbon pump, the ocean state estimates will provide additional information on physical and carbon cycle processes, including the air-sea CO2 fluxes of the Southern Ocean in the 2006-2013 period where model solutions have been optimized.These physical estimates will be used to force an ocean biogeochemical model (ECCO2-Darwin) that will compute the CO2 uptake for each year. The physical model, forced with optimized atmospheric forcing, aims to realistically simulate interannual ocean climate variability that drives changes in both physical and biogeochemical processes ultimately impacting the carbon uptake of the Southern Ocean, and potentially responding to the SAM index variations.Although in this study great emphasis is given to the role of physical climate variations at driving the CO2 uptake of these polar waters, we will integrate model results with estimates from remote sensing techniques to better understand role of the biological carbon pump and its variability potentially responding to the SAM index changes.

The Ocean Carbon States Database: A Proof-of-Concept Application of Cluster Analysis in the Ocean Carbon Cycle

NASA Technical Reports Server (NTRS)

Latto, Rebecca; Romanou, Anastasia

2018-01-01

In this paper, we present a database of the basic regimes of the carbon cycle in the ocean, the 'ocean carbon states', as obtained using a data mining/pattern recognition technique in observation-based as well as model data. The goal of this study is to establish a new data analysis methodology, test it and assess its utility in providing more insights into the regional and temporal variability of the marine carbon cycle. This is important as advanced data mining techniques are becoming widely used in climate and Earth sciences and in particular in studies of the global carbon cycle, where the interaction of physical and biogeochemical drivers confounds our ability to accurately describe, understand, and predict CO2 concentrations and their changes in the major planetary carbon reservoirs. In this proof-of-concept study, we focus on using well-understood data that are based on observations, as well as model results from the NASA Goddard Institute for Space Studies (GISS) climate model. Our analysis shows that ocean carbon states are associated with the subtropical-subpolar gyre during the colder months of the year and the tropics during the warmer season in the North Atlantic basin. Conversely, in the Southern Ocean, the ocean carbon states can be associated with the subtropical and Antarctic convergence zones in the warmer season and the coastal Antarctic divergence zone in the colder season. With respect to model evaluation, we find that the GISS model reproduces the cold and warm season regimes more skillfully in the North Atlantic than in the Southern Ocean and matches the observed seasonality better than the spatial distribution of the regimes. Finally, the ocean carbon states provide useful information in the model error attribution. Model air-sea CO2 flux biases in the North Atlantic stem from wind speed and salinity biases in the subpolar region and nutrient and wind speed biases in the subtropics and tropics. Nutrient biases are shown to be most important in the Southern Ocean flux bias.

Impacts of Atmosphere-Ocean Coupling on Southern Hemisphere Climate Change

NASA Technical Reports Server (NTRS)

Li, Feng; Newman, Paul; Pawson, Steven

2013-01-01

Climate in the Southern Hemisphere (SH) has undergone significant changes in recent decades. These changes are closely linked to the shift of the Southern Annular Mode (SAM) towards its positive polarity, which is driven primarily by Antarctic ozone depletion. There is growing evidence that Antarctic ozone depletion has significant impacts on Southern Ocean circulation change. However, it is poorly understood whether and how ocean feedback might impact the SAM and climate change in the SH atmosphere. This outstanding science question is investigated using the Goddard Earth Observing System Coupled Atmosphere-Ocean-Chemistry Climate Model(GEOS-AOCCM).We perform ensemble simulations of the recent past (1960-2010) with and without the interactive ocean. For simulations without the interactive ocean, we use sea surface temperatures and sea ice concentrations produced by the interactive ocean simulations. The differences between these two ensemble simulations quantify the effects of atmosphere-ocean coupling. We will investigate the impacts of atmosphere-ocean coupling on stratospheric processes such as Antarctic ozone depletion and Antarctic polar vortex breakup. We will address whether ocean feedback affects Rossby wave generation in the troposphere and wave propagation into the stratosphere. Another focuson this study is to assess how ocean feedback might affect the tropospheric SAM response to Antarctic ozone depletion

Do Patients and Oncologists Discuss the Cost of Cancer Treatment? An Observational Study of Clinical Interactions Between African American Patients and Their Oncologists.

PubMed

Hamel, Lauren M; Penner, Louis A; Eggly, Susan; Chapman, Robert; Klamerus, Justin F; Simon, Michael S; Stanton, Sarah C E; Albrecht, Terrance L

2017-03-01

Financial toxicity negatively affects patients with cancer, especially racial/ethnic minorities. Patient-oncologist discussions about treatment-related costs may reduce financial toxicity by factoring costs into treatment decisions. This study investigated the frequency and nature of cost discussions during clinical interactions between African American patients and oncologists and examined whether cost discussions were affected by patient sociodemographic characteristics and social support, a known buffer to perceived financial stress. Methods Video recorded patient-oncologist clinical interactions (n = 103) from outpatient clinics of two urban cancer hospitals (including a National Cancer Institute-designated comprehensive cancer center) were analyzed. Coders studied the videos for the presence and duration of cost discussions and then determined the initiator, topic, oncologist response to the patient's concerns, and the patient's reaction to the oncologist's response. Cost discussions occurred in 45% of clinical interactions. Patients initiated 63% of discussions; oncologists initiated 36%. The most frequent topics were concern about time off from work for treatment (initiated by patients) and insurance (initiated by oncologists). Younger patients and patients with more perceived social support satisfaction were more likely to discuss cost. Patient age interacted with amount of social support to affect frequency of cost discussions within interactions. Younger patients with more social support had more cost discussions; older patients with more social support had fewer cost discussions. Cost discussions occurred in fewer than one half of the interactions and most commonly focused on the impact of the diagnosis on patients' opportunity costs rather than treatment costs. Implications for ASCO's Value Framework and design of interventions to improve cost discussions are discussed.

Modeling High-Resolution Coastal Ocean Dynamics with COAMPS: System Overview, Applications and Future Directions

NASA Astrophysics Data System (ADS)

Allard, R. A.; Campbell, T. J.; Edwards, K. L.; Smith, T.; Martin, P.; Hebert, D. A.; Rogers, W.; Dykes, J. D.; Jacobs, G. A.; Spence, P. L.; Bartels, B.

2014-12-01

The Coupled Ocean Atmosphere Mesoscale Prediction System (COAMPS®) is an atmosphere-ocean-wave modeling system developed by the Naval Research Laboratory which can be configured to cycle regional forecasts/analysis models in single-model (atmosphere, ocean, and wave) or coupled-model (atmosphere-ocean, ocean-wave, and atmosphere-ocean-wave) modes. The model coupling is performed using the Earth System Modeling Framework (ESMF). The ocean component is the Navy Coastal Ocean Model (NCOM), and the wave components include Simulating WAves Nearshore (SWAN) and WaveWatch-III. NCOM has been modified to include wetting and drying, the effects of Stokes drift current, wave radiation stresses due to horizontal gradients of the momentum flux of surface waves, enhancement of bottom drag in shallow water, and enhanced vertical mixing due to Langmuir turbulence. An overview of the modeling system including ocean data assimilation and specification of boundary conditions will be presented. Results from a high-resolution (10-250m) modeling study from the Surfzone Coastal Oil Pathways Experiment (SCOPE) near Ft. Walton Beach, Florida in December 2013 will be presented. ®COAMPS is a registered trademark of the Naval Research Laboratory

Sensitivity of the Arctic Ocean gas hydrate to climate changes in the period of 1948-2015

NASA Astrophysics Data System (ADS)

Malakhova, Valentina V.; Golubeva, Elena N.; Iakshina, Dina F.

2017-11-01

The objective of the present study is to analyze the interactions between a methane hydrates stability zone and the ocean temperature variations and to define the hydrate sensitivity to the contemporary warming in the Arctic Ocean. To obtain the spatial-temporary variability of the ocean bottom temperature we employ the ICMMG regional Arctic-North Atlantic ocean model that has been developed in the Institute of Computational Mathematics and Mathematical Geophysics. With the ice-ocean model the Arctic bottom water temperatures were analyzed. The resulting warming ocean bottom water is spatially inhomogeneous, with a strong impact by the Atlantic inflow on shallow regions of 200-500 m depth. Results of the mathematical modeling of the dynamics of methane hydrate stability zone in the Arctic Ocean sediment are reported. We find that the reduction of the methane hydrate stability zone occurs in the Arctic Ocean between 250 and 400 m water depths within the upper 100 m of sediment in the area influenced by the Atlantic inflow. We have identified the areas of the Arctic Ocean where an increase in methane release is probable to occur at the present time.

Effect of Atmospheric Organics on Bioavailable Fe Lifetime in the Oceans

NASA Technical Reports Server (NTRS)

Meskhidze, Nicholas; Hurley, David; Royalty, Taylor Michael; Johnson, Matthew S.

2016-01-01

The deposition of atmospheric aerosols is an important supply pathway of soluble iron (sol-Fe) to the global oceans influencing marine ecosystem processes and climate. Previous studies have shown that natural and anthropogenic acidic trace gases, when mixed with mineral dust, can lead to production of sol-Fe, leading to considerable increase in dust-Fe solubility. Recent studies have further highlighted the importance of atmospheric organic compounds/ligands in the production of sol-Fe during atmospheric transport and transformation of mineral aerosols. However, the actual scope of this aerosol sol-Fe for stimulating the primary productivity in the oceans is determined by both: the total atmospheric fluxes of sol-Fe and the lifetime of sol-Fe after its deposition to the ocean. In this study several atmospheric organic ligands were investigated for their effect on the lifetime of sol-Fe after mixing with seawater. Organic ligands were selected based on their abundance in the marine boundary layer and rainwater and their ability to form bidentate complexes with Fe. The results reveal that the tested organics had minor influence on Fe(II) lifetime in seawater. However, results also show that some organic acid considerably extended the lifetime of colloidal and aqueous Fe(III). Using these results we simulate aerosol sol-Fe lifetime in the ocean for different mineral dust deposition events in the presence and the absence of atmospheric organic ligands. The calculations suggest that when a large dust plume is assumed to contain Fe(II) alone, less than 15% of aerosol sol-Fe gets complexed with marine organic ligands. However, this fraction increases to over 90% when atmospheric Fe is allowed to bond with atmospheric organic acids prior to deposition to the oceans. Calculations also show that for the conditions when seawater organic ligands get titrated by Fe released from dust aerosol particles, retention of sol-Fe in the ocean depends on surface ocean mixing, i.e., replenishing rates for Fe-bonding ligands from below. This study suggests that in future ocean biogeochemistry models more attention should be devoted to better quantification of the role of atmospheric organic acids in the lifetime of aerosol sol-Fe after its deposition to the ocean and the improvements of upper ocean turbulence parameterizations.

Seasonal dynamics of surface chlorophyll concentration and sea surface temperature, as indicator of hydrological structure of the ocean (by satellite data)

NASA Astrophysics Data System (ADS)

Shevyrnogov, Anatoly; Vysotskaya, Galina

Continuous monitoring of phytopigment concentrations and sea surface temperature in the ocean by space-borne methods makes possible to estimate ecological condition of biocenoses in critical areas. Unlike land vegetation, hydrological processes largely determine phytoplank-ton dynamics, which may be either recurrent or random. The types of chlorophyll concentration dynamics and sea surface temperature can manifest as zones quasistationary by seasonal dynamics, quasistationary areas (QSA). In the papers of the authors (A. Shevyrnogov, G. Vysotskaya, E. Shevyrnogov, A study of the stationary and the anomalous in the ocean surface chlorophyll distribution by satellite data. International Journal of Remote Sensing, Vol. 25, No.7-8, pp. 1383-1387, April 2004 & A. P. Shevyrnogov, G. S. Vysotskaya, J. I. Gitelson, Quasistationary areas of chlorophyll concentra-tion in the world ocean as observed satellite data Advances in Space Research, Volume 18, Issue 7, Pages 129-132, 1996) existence of zones, which are quasi-stationary with similar seasonal dynamics of chlorophyll concentration at surface layer of ocean, was shown. Results were obtained on the base of processing of time series of satellite images SeaWiFS. It was shown that fronts and frontal zones coincide with dividing lines between quasi-stationary are-as, especially in areas of large oceanic streams. To study the dynamics of the ocean for the period from 1985 through 2012 we used data on the temperature of the surface layer of the ocean and chlorophyll concentration (AVHRR, SeaWiFS and MODIS). Biota of surface oceanic layer is more stable in comparison with quickly changing surface tem-perature. It gives a possibility to circumvent influence of high-frequency component (for exam-ple, a diurnal cycle) in investigation of dynamics of spatial distribution of surface streams. In addition, an analyses of nonstable ocean productivity phenomena, stood out time series of satellite images, showed existence of areas with different types of instability in the all Global ocean. They are observed as adjacent nonstationary zones of different size, which are associ-ated by different ways with known oceanic phenomena. It is evident that dynamics of a spatial distribution of biological productivity can give an additional knowledge of complicated picture of surface oceanic layer hydrology. In this study we demonstrate different origin of appearance of quasistationary zones in the ocean. We can see that the border between quasi¬stationary zones is an indicator of the front between the Labrador Current and Gulfstream, other example of revealed pheno¬menon is a qua-sistationary area around of the British Isles that correlates with the relief of the oceanic bottom. Considering that the QSA maps are calculated almost for all surface of the Global ocean, not all QSA can be explained especially of small size. Although some small QSA are interesting. Also local QSA near estuaries of large rivers and large industrial centers, that can be result of a human impact. In sum satellite data is a powerful instrument for investigation of dynamic oceanic processes, their stability and unstability. The result of such study can be used for monitoring of long-term changes and their correlation of with climate dynamics.

Geostrophic Turbulence in the Frequency-Wavenumber Domain: Eddy-Driven Low-Frequency Variability

DTIC Science & Technology

2014-01-01

in ASFMRS. Previous studies of oceanic frequency– wavenumber spectra include Wunsch and Stammer (1995), Chelton and Schlax (1996), Farrar (2008...ASFMRS. However, the realistic eddying ocean model utilized here is the Hy- brid Coordinate Ocean Model (HYCOM; Chassignet et al. 2007 ), in place of...the Naval Research Laboratory (NRL) Layered Ocean Model (NLOM; Hurlburt and AUGUST 2014 ARB I C ET AL . 2051 Thompson 1980; Shriver et al. 2007 ) used

Estimating Advective Near-surface Currents from Ocean Color Satellite Images

DTIC Science & Technology

2015-01-01

of surface current information. The present study uses the sequential ocean color products provided by the Geostationary Ocean Color Imager (GOCI) and...on the SuomiNational Polar-Orbiting Partner- ship (S-NPP) satellite. The GOCI is the world’s first geostationary orbit satellite sensor over the...used to extract the near-surface currents by the MCC algorithm. We not only demonstrate the retrieval of currents from the geostationary satellite ocean

Development of improved space sampling strategies for ocean chemical properties: Total carbon dioxide and dissolved nitrate

NASA Technical Reports Server (NTRS)

Goyet, Catherine; Davis, Daniel; Peltzer, Edward T.; Brewer, Peter G.

1995-01-01

Large-scale ocean observing programs such as the Joint Global Ocean Flux Study (JGOFS) and the World Ocean Circulation Experiment (WOCE) today, must face the problem of designing an adequate sampling strategy. For ocean chemical variables, the goals and observing technologies are quite different from ocean physical variables (temperature, salinity, pressure). We have recently acquired data on the ocean CO2 properties on WOCE cruises P16c and P17c that are sufficiently dense to test for sampling redundancy. We use linear and quadratic interpolation methods on the sampled field to investigate what is the minimum number of samples required to define the deep ocean total inorganic carbon (TCO2) field within the limits of experimental accuracy (+/- 4 micromol/kg). Within the limits of current measurements, these lines were oversampled in the deep ocean. Should the precision of the measurement be improved, then a denser sampling pattern may be desirable in the future. This approach rationalizes the efficient use of resources for field work and for estimating gridded (TCO2) fields needed to constrain geochemical models.

The positive Indian Ocean Dipole-like response in the tropical Indian Ocean to global warming

DOE Office of Scientific and Technical Information (OSTI.GOV)

Luo, Yiyong; Lu, Jian; Liu, Fukai

Climate models project a positive Indian Ocean Dipole (pIOD)-like SST response in the tropical Indian Ocean to global warming. By employing the Community Earth System Model (CESM) and applying an overriding technique to its ocean component Parallel Ocean Program version 2 (POP2), this study investigates the similarity and difference of the formation mechanisms for the changes in the tropical Indian Ocean during the pIOD versus global warming. Results show that their formation processes and related seasonality are quite similar; in particular, the Bjerknes feedback is the leading mechanism in producing the anomalous cooling over the eastern tropics in both cases.more » Some differences are also found, including that the cooling effect of the vertical advection over the eastern tropical Indian Ocean is dominated by the anomalous vertical velocity during the pIOD while it is dominated by the anomalous upper-ocean stratification under global warming. Lastly, these findings above are further examined with an analysis of the mixed layer heat budget.« less

The positive Indian Ocean Dipole-like response in the tropical Indian Ocean to global warming

DOE PAGES

Luo, Yiyong; Lu, Jian; Liu, Fukai; ...

2016-02-04

Climate models project a positive Indian Ocean Dipole (pIOD)-like SST response in the tropical Indian Ocean to global warming. By employing the Community Earth System Model (CESM) and applying an overriding technique to its ocean component Parallel Ocean Program version 2 (POP2), this study investigates the similarity and difference of the formation mechanisms for the changes in the tropical Indian Ocean during the pIOD versus global warming. Results show that their formation processes and related seasonality are quite similar; in particular, the Bjerknes feedback is the leading mechanism in producing the anomalous cooling over the eastern tropics in both cases.more » Some differences are also found, including that the cooling effect of the vertical advection over the eastern tropical Indian Ocean is dominated by the anomalous vertical velocity during the pIOD while it is dominated by the anomalous upper-ocean stratification under global warming. Lastly, these findings above are further examined with an analysis of the mixed layer heat budget.« less

Retrieval of Ocean Subsurface Particulate Backscattering Coefficient from Space-Borne CALIOP Lidar Measurement

NASA Technical Reports Server (NTRS)

Lu, Xiaomei; Hu, Yongxiang; Pelon, Jacques; Trepte, Chip; Liu, Katie; Rodier, Sharon; Zeng, Shan; Luckher, Patricia; Verhappen, Ron; Wilson, Jamie;

A study of the dynamics of the Intertropical Convergence Zone (ITCZ) in a symmetric atmosphere-ocean model

NASA Technical Reports Server (NTRS)

Charney, J. G.; Kalnay, E.; Schneider, E.; Shukla, J.

1988-01-01

A numerical model of the circulation of a coupled axisymmetric atmosphere-ocean system was constructed to investigate the physical factors governing the location and intensity of the Intertropical Convergence Zone (ITCZ) over oceans and over land. The results of several numerical integrations are presented to illustrate the interaction of the individual atmospheric and oceanic circulations. It is shown that the ITCA cannot be located at the equator because the atmosphere-ocean system is unstable for lateral displacements of the ITCA from an equilibrium position at the equator.

Sensitivity of Ocean Chemistry and Oxygen Change to the Uncertainty in Climate Change

NASA Astrophysics Data System (ADS)

Cao, L.; Wang, S.; Zheng, M.; Zhang, H.

2014-12-01

With increasing atmospheric CO2 and climate change, global ocean is undergoing substantial physical and biogeochemical changes. In particular, changes in ocean oxygen and carbonate chemistry have great implication for marine biota. There is considerable uncertainty in the projections of future climate change, and it is unclear how the uncertainty in climate change would affect the projection of ocean oxygen and carbonate chemistry. To examine the effect of climate change on ocean oxygen and carbonate chemistry, we used an Earth system model of intermediate complexity to perform simulations that are driven by atmospheric CO2 concentration pathway of RCP 8.5 with climate sensitivity varying from 0.0°C to 4.5 °C. Climate change affects carbonate chemistry and oxygen mainly through its impact on ocean temperature, ocean ventilation, and concentration of dissolved inorganic carbon and alkalinity. Our simulations show that climate change mitigates the decrease of carbonate ions at the ocean surface but has negligible effect on surface ocean pH. Averaged over the whole ocean, climate change acts to decrease oxygen concentration but mitigates the CO2-induced reduction of carbonate ion and pH. In our simulations, by year 2500, every degree increase of climate sensitivity warms the ocean by 0.8 °C and reduces ocean-mean dissolved oxygen concentration by 5.0%. Meanwhile, every degree increase of climate sensitivity buffers CO2-induced reduction in ocean-mean carbonate ion concentration and pH by 3.4% and 0.02 units, respectively. Our study demonstrates different sensitivities of ocean temperature, carbonate chemistry, and oxygen, in terms of both the sign and magnitude, to the amount of climate change, which have great implications for understanding the response of ocean biota to climate change.

Consensuses and discrepancies of basin-scale ocean heat content changes in different ocean analyses

NASA Astrophysics Data System (ADS)

Wang, Gongjie; Cheng, Lijing; Abraham, John; Li, Chongyin

2018-04-01

Inconsistent global/basin ocean heat content (OHC) changes were found in different ocean subsurface temperature analyses, especially in recent studies related to the slowdown in global surface temperature rise. This finding challenges the reliability of the ocean subsurface temperature analyses and motivates a more comprehensive inter-comparison between the analyses. Here we compare the OHC changes in three ocean analyses (Ishii, EN4 and IAP) to investigate the uncertainty in OHC in four major ocean basins from decadal to multi-decadal scales. First, all products show an increase of OHC since 1970 in each ocean basin revealing a robust warming, although the warming rates are not identical. The geographical patterns, the key modes and the vertical structure of OHC changes are consistent among the three datasets, implying that the main OHC variabilities can be robustly represented. However, large discrepancies are found in the percentage of basinal ocean heating related to the global ocean, with the largest differences in the Pacific and Southern Ocean. Meanwhile, we find a large discrepancy of ocean heat storage in different layers, especially within 300-700 m in the Pacific and Southern Oceans. Furthermore, the near surface analysis of Ishii and IAP are consistent with sea surface temperature (SST) products, but EN4 is found to underestimate the long-term trend. Compared with ocean heat storage derived from the atmospheric budget equation, all products show consistent seasonal cycles of OHC in the upper 1500 m especially during 2008 to 2012. Overall, our analyses further the understanding of the observed OHC variations, and we recommend a careful quantification of errors in the ocean analyses.

Asian dust transportation and fertilizing the coastal and open ocean in the Northern Pacific (Invited)

NASA Astrophysics Data System (ADS)

Gao, H.; Xiaohong Yao, Jinhui Shi, Jianhua Qi

2010-12-01

Dust storm carries a large amount of aerosol particles, sweeps continents and exports to oceans. When these aerosol particles deposit in ocean, which provides abundant nutrients such as nitrogen and iron for ocean ecosystem, increases the primary production and induces algae bloom. Asian dust storm generates at a high latitude and a high elevation and is obvious a hemispheric scale phenomenon. Dust sources in East Asia are one of the major dust sources on the earth which contribute to 5%-40% of the global dust release. The regions affected by the Asian dust storm include not only China and Mongolia but also the downwind Korea, Japan, the Pacific Ocean, the west coast of America, even the subarctic region and Europe. The Asian dust storm is obviously a hemispheric scale phenomenon, which has more important impact on the ecosystem in the western Pacific. Asian dust is unique not only in morphology, soil texture, and dust storm activities, but also mixing and capturing anthropogenic air pollutants on the transport pathway. Deposition of Asian dust substantially affects surface biological productivity. To improve understandings of Asian dust and its effect on ocean ecosystem from the coastal sea to open ocean, ADOES (Asian Dust and Ocean EcoSystem) was proposed under the frame of international SOLAS (Surface Ocean-Lower Atmosphere Study). A series of studies were performed in high- nutrient low-chlorophyll (HNLC), low-nutrient low-chlorophyll (LNLC) and eutrophication coastal regions of the Pacific Ocean. These studies provided evidence of biotic response to natural iron fertilization caused by Asian dust particles in the subarctic North Pacific and showed that dust storm episodes were significant in the initiation of spring blooms in the East China Sea. On-board incubations on the cruise in a LNLC region of the western Pacific at the southeast of Japan showed different responses of ocean ecosystem to nitrogen and dust fertilization. Correlation of the Asian dust storms with chlorophyll, primary productivity and algae blooms in the coastal seas of China from 1998 to 2008 were also illustrated.

Biogeochemical Reactions Under Simulated Europa Ocean Conditions

NASA Astrophysics Data System (ADS)

Amashukeli, X.; Connon, S. A.; Gleeson, D. F.; Kowalczyk, R. S.; Pappalardo, R. T.

2007-12-01

Galileo data have demonstrated the probable presence of a liquid water ocean on Europa, and existence of salts and carbon dioxide in the satellite's surface ice (e.g., Carr et al., 1998; McCord et al., 1999, Pappalardo et al., 1999; Kivelson et al., 2000). Subsequently, the discovery of chemical signatures of extinct or extant life in Europa's ocean and on its surface became a distinct possibility. Moreover, understanding of Europa's potential habitability is now one of the major goals of the Europa Orbiter Flagship mission. It is likely, that in the early stages of Europa's ocean formation, moderately alkaline oceanic sulfate-carbonate species and a magnetite-silicate mantel could have participated in low-temperature biogeochemical sulfur, iron and carbon cycles facilitated by primitive organisms (Zolotov and Shock, 2004). If periodic supplies of fresh rock and sulfate-carbonate ions are available in Europa's ocean, then an exciting prospect exists that life may be present in Europa's ocean today. In our laboratory, we began the study of the plausible biogeochemical reactions under conditions appropriate to Europa's ocean using barophilic psychrophilic organisms that thrive under anaerobic conditions. In the near absence of abiotic synthetic pathways due to low Europa's temperatures, the biotic synthesis may present a viable opportunity for the formation of the organic and inorganic compounds under these extreme conditions. This work is independent of assumptions regarding hydrothermal vents at Europa's ocean floor or surface-derived oxidant sources. For our studies, we have fabricated a high-pressure (5,000 psi) reaction vessel that simulates aqueous conditions on Europa. We were also successful at reviving barophilic psychrophilic strains of Shewanella bacterium, which serve as test organisms in this investigation. Currently, facultative barophilic psychrophilic stains of Shewanella are grown in the presence of ferric food source; the strains exhibiting iron reduction capability will be later selected and used to facilitate biogeochemical reduction of iron under simulated temperature and pressure of Europa's ocean. The results of this work will enable us to ascertain whether Europa's cold, high-pressure ocean is capable of supporting life. In addition, the data from this study will help in generating a list of organic and inorganic target molecules for future remote sensing and in situ exploration missions.

Communicating Ocean Acidification

ERIC Educational Resources Information Center

Pope, Aaron; Selna, Elizabeth

2013-01-01

Participation in a study circle through the National Network of Ocean and Climate Change Interpretation (NNOCCI) project enabled staff at the California Academy of Sciences to effectively engage visitors on climate change and ocean acidification topics. Strategic framing tactics were used as staff revised the scripted Coral Reef Dive program,…

Under the sea: microbial life in volcanic oceanic crust.

PubMed

Edwards, Katrina J; Wheat, C Geoffrey; Sylvan, Jason B

2011-09-06

Exploration of the microbiology in igneous, 'hard rock' oceanic crust represents a major scientific frontier. The igneous crust harbours the largest aquifer system on Earth, most of which is hydrologically active, resulting in a substantial exchange of fluids, chemicals and microorganisms between oceanic basins and crustal reservoirs. Study of the deep-subsurface biosphere in the igneous crust is technically challenging. However, technologies have improved over the past decade, providing exciting new opportunities for the study of deep-seated marine life, including in situ and cross-disciplinary experimentation in microbiology, geochemistry and hydrogeology. In this Progress article, we describe the recent advances, available technology and remaining challenges in the study of the marine intraterrestrial microbial life that is harboured in igneous oceanic crust.

Ups and Downs in the Ocean: Effects of Biofouling on Vertical Transport of Microplastics.

PubMed

Kooi, Merel; Nes, Egbert H van; Scheffer, Marten; Koelmans, Albert A

2017-07-18

Recent studies suggest size-selective removal of small plastic particles from the ocean surface, an observation that remains unexplained. We studied one of the hypotheses regarding this size-selective removal: the formation of a biofilm on the microplastics (biofouling). We developed the first theoretical model that is capable of simulating the effect of biofouling on the fate of microplastic. The model is based on settling, biofilm growth, and ocean depth profiles for light, water density, temperature, salinity, and viscosity. Using realistic parameters, the model simulates the vertical transport of small microplastic particles over time, and predicts that the particles either float, sink to the ocean floor, or oscillate vertically, depending on the size and density of the particle. The predicted size-dependent vertical movement of microplastic particles results in a maximum concentration at intermediate depths. Consequently, relatively low abundances of small particles are predicted at the ocean surface, while at the same time these small particles may never reach the ocean floor. Our results hint at the fate of "lost" plastic in the ocean, and provide a start for predicting risks of exposure to microplastics for potentially vulnerable species living at these depths.

Shift in tuna catches due to ocean warming.

PubMed

Monllor-Hurtado, Alberto; Pennino, Maria Grazia; Sanchez-Lizaso, José Luis

2017-01-01

Ocean warming is already affecting global fisheries with an increasing dominance of catches of warmer water species at higher latitudes and lower catches of tropical and subtropical species in the tropics. Tuna distributions are highly conditioned by sea temperature, for this reason and their worldwide distribution, their populations may be a good indicator of the effect of climate change on global fisheries. This study shows the shift of tuna catches in subtropical latitudes on a global scale. From 1965 to 2011, the percentage of tropical tuna in longliner catches exhibited a significantly increasing trend in a study area that included subtropical regions of the Atlantic and western Pacific Oceans and partially the Indian Ocean. This may indicate a movement of tropical tuna populations toward the poles in response to ocean warming. Such an increase in the proportion of tropical tuna in the catches does not seem to be due to a shift of the target species, since the trends in Atlantic and Indian Oceans of tropical tuna catches are decreasing. Our results indicate that as populations shift towards higher latitudes the catches of these tropical species did not increase. Thus, at least in the Atlantic and Indian Oceans, tropical tuna catches have reduced in tropical areas.

The pathways of Marine Plastic into the Ocean Garbage Patches

NASA Astrophysics Data System (ADS)

van Sebille, E.; England, M. H.; Froyland, G.

2013-12-01

Much of the plastic debris in the near-surface ocean collects in so-called garbage patches where, due to convergence of the surface flow, the debris is trapped for decades to millennia. Here, we use observational data from the Global Drifter Program in a particle-trajectory tracer approach to study the fate of marine debris in the open ocean from coastal regions around the world on interannual to centennial time scales. We find that garbage patches emerge in each of the five subtropical basins. The evolution of each of the five patches is markedly different, however. With the exception of the North Pacific, all patches are much more dispersive than expected from linear ocean circulation theory, suggesting that on centennial time scales the different basins are much better connected than previously thought and that inter-ocean exchanges play a large role in the spreading of marine debris. In order to increase public awareness on this issue of sustainability in the ocean, we have used the methods and data of this study to create a public website at www.adrift.org.au where all interested can investigate the spread of tracer from any and all points on the ocean surface.

A reanalysis dataset of the South China Sea.

PubMed

Zeng, Xuezhi; Peng, Shiqiu; Li, Zhijin; Qi, Yiquan; Chen, Rongyu

2014-01-01

Ocean reanalysis provides a temporally continuous and spatially gridded four-dimensional estimate of the ocean state for a better understanding of the ocean dynamics and its spatial/temporal variability. Here we present a 19-year (1992-2010) high-resolution ocean reanalysis dataset of the upper ocean in the South China Sea (SCS) produced from an ocean data assimilation system. A wide variety of observations, including in-situ temperature/salinity profiles, ship-measured and satellite-derived sea surface temperatures, and sea surface height anomalies from satellite altimetry, are assimilated into the outputs of an ocean general circulation model using a multi-scale incremental three-dimensional variational data assimilation scheme, yielding a daily high-resolution reanalysis dataset of the SCS. Comparisons between the reanalysis and independent observations support the reliability of the dataset. The presented dataset provides the research community of the SCS an important data source for studying the thermodynamic processes of the ocean circulation and meso-scale features in the SCS, including their spatial and temporal variability.

A reanalysis dataset of the South China Sea

PubMed Central

Zeng, Xuezhi; Peng, Shiqiu; Li, Zhijin; Qi, Yiquan; Chen, Rongyu

2014-01-01

Ocean reanalysis provides a temporally continuous and spatially gridded four-dimensional estimate of the ocean state for a better understanding of the ocean dynamics and its spatial/temporal variability. Here we present a 19-year (1992–2010) high-resolution ocean reanalysis dataset of the upper ocean in the South China Sea (SCS) produced from an ocean data assimilation system. A wide variety of observations, including in-situ temperature/salinity profiles, ship-measured and satellite-derived sea surface temperatures, and sea surface height anomalies from satellite altimetry, are assimilated into the outputs of an ocean general circulation model using a multi-scale incremental three-dimensional variational data assimilation scheme, yielding a daily high-resolution reanalysis dataset of the SCS. Comparisons between the reanalysis and independent observations support the reliability of the dataset. The presented dataset provides the research community of the SCS an important data source for studying the thermodynamic processes of the ocean circulation and meso-scale features in the SCS, including their spatial and temporal variability. PMID:25977803

Restricted regions of enhanced growth of Antarctic krill in the circumpolar Southern Ocean.

PubMed

Murphy, Eugene J; Thorpe, Sally E; Tarling, Geraint A; Watkins, Jonathan L; Fielding, Sophie; Underwood, Philip

2017-07-31

Food webs in high-latitude oceans are dominated by relatively few species. Future ocean and sea-ice changes affecting the distribution of such species will impact the structure and functioning of whole ecosystems. Antarctic krill (Euphausia superba) is a key species in Southern Ocean food webs, but there is little understanding of the factors influencing its success throughout much of the ocean. The capacity of a habitat to maintain growth will be crucial and here we use an empirical relationship of growth rate to assess seasonal spatial variability. Over much of the ocean, potential for growth is limited, with three restricted oceanic regions where seasonal conditions permit high growth rates, and only a few areas around the Scotia Sea and Antarctic Peninsula suitable for growth of the largest krill (>60 mm). Our study demonstrates that projections of impacts of future change need to account for spatial and seasonal variability of key ecological processes within ocean ecosystems.

Introduction to Special Section on Oceanic Responses and Feedbacks to Tropical Cyclones

NASA Astrophysics Data System (ADS)

Zhou, Lei; Chen, Dake; Karnauskas, Kristopher B.; Wang, Chunzai; Lei, Xiaotu; Wang, Wei; Wang, Guihua; Han, Guijun

2018-02-01

Tropical cyclones (TCs) are among the most destructive natural hazards on Earth. The ocean can have dramatic responses to TCs and further imposes significant feedbacks to the atmosphere. A comprehensive understanding of the ocean-TC interaction is a challenging hindrance for improving the simulation and prediction of TCs and therefore avoidance of human and economic losses. A special section of JGR-Oceans was thus organized, in order to have a broad summary of latest progress in ocean-TC interactions. This introduction presents a brief overview of the contributions found in this collection. We hope it can also shed light on recent advance and future challenges in the studies on the oceanic responses and feedbacks to TCs.

Ocean acidification postcards

USGS Publications Warehouse

Schreppel, Heather A.; Cimitile, Matthew J.

2011-01-01

The U.S. Geological Survey (USGS) is conducting research on ocean acidification in polar, temperate, subtropical, and tropical regions including the Arctic, West Florida Shelf, and the Caribbean. Project activities include field assessment, experimental laboratory studies, and evaluation of existing data. The USGS is participating in international and interagency working groups to develop research strategies to increase understanding of the global implications of ocean acidification. Research strategies include new approaches for seawater chemistry observation and modeling, assessment of physiological effects on organisms, changes in marine ecosystem structure, new technologies, and information resources. These postcards highlight ongoing USGS research efforts in ocean acidification and carbon cycling in marine and coastal ecosystems in three different regions: polar, temperate, and tropical. To learn more about ocean acidification visit: http://coastal.er.usgs.gov/ocean-acidification/.

Ocean acidification: Linking science to management solutions using the Great Barrier Reef as a case study.

PubMed

Albright, Rebecca; Anthony, Kenneth R N; Baird, Mark; Beeden, Roger; Byrne, Maria; Collier, Catherine; Dove, Sophie; Fabricius, Katharina; Hoegh-Guldberg, Ove; Kelly, Ryan P; Lough, Janice; Mongin, Mathieu; Munday, Philip L; Pears, Rachel J; Russell, Bayden D; Tilbrook, Bronte; Abal, Eva

2016-11-01

Coral reefs are one of the most vulnerable ecosystems to ocean acidification. While our understanding of the potential impacts of ocean acidification on coral reef ecosystems is growing, gaps remain that limit our ability to translate scientific knowledge into management action. To guide solution-based research, we review the current knowledge of ocean acidification impacts on coral reefs alongside management needs and priorities. We use the world's largest continuous reef system, Australia's Great Barrier Reef (GBR), as a case study. We integrate scientific knowledge gained from a variety of approaches (e.g., laboratory studies, field observations, and ecosystem modelling) and scales (e.g., cell, organism, ecosystem) that underpin a systems-level understanding of how ocean acidification is likely to impact the GBR and associated goods and services. We then discuss local and regional management options that may be effective to help mitigate the effects of ocean acidification on the GBR, with likely application to other coral reef systems. We develop a research framework for linking solution-based ocean acidification research to practical management options. The framework assists in identifying effective and cost-efficient options for supporting ecosystem resilience. The framework enables on-the-ground OA management to be the focus, while not losing sight of CO2 mitigation as the ultimate solution. Copyright © 2016 Elsevier Ltd. All rights reserved.

Food web changes under ocean acidification promote herring larvae survival.

PubMed

Sswat, Michael; Stiasny, Martina H; Taucher, Jan; Algueró-Muñiz, Maria; Bach, Lennart T; Jutfelt, Fredrik; Riebesell, Ulf; Clemmesen, Catriona

2018-05-01

Ocean acidification-the decrease in seawater pH due to rising CO 2 concentrations-has been shown to lower survival in early life stages of fish and, as a consequence, the recruitment of populations including commercially important species. To date, ocean-acidification studies with fish larvae have focused on the direct physiological impacts of elevated CO 2 , but largely ignored the potential effects of ocean acidification on food web interactions. In an in situ mesocosm study on Atlantic herring (Clupea harengus) larvae as top predators in a pelagic food web, we account for indirect CO 2 effects on larval survival mediated by changes in food availability. The community was exposed to projected end-of-the-century CO 2 conditions (~760 µatm pCO 2 ) over a period of 113 days. In contrast with laboratory studies that reported a decrease in fish survival, the survival of the herring larvae in situ was significantly enhanced by 19 ± 2%. Analysis of the plankton community dynamics suggested that the herring larvae benefitted from a CO 2 -stimulated increase in primary production. Such indirect effects may counteract the possible direct negative effects of ocean acidification on the survival of fish early life stages. These findings emphasize the need to assess the food web effects of ocean acidification on fish larvae before we can predict even the sign of change in fish recruitment in a high-CO 2 ocean.

Prevalence of the Chloroflexi-Related SAR202 Bacterioplankton Cluster throughout the Mesopelagic Zone and Deep Ocean†

PubMed Central

Morris, R. M.; Rappé, M. S.; Urbach, E.; Connon, S. A.; Giovannoni, S. J.

2004-01-01

Since their initial discovery in samples from the north Atlantic Ocean, 16S rRNA genes related to the environmental gene clone cluster known as SAR202 have been recovered from pelagic freshwater, marine sediment, soil, and deep subsurface terrestrial environments. Together, these clones form a major, monophyletic subgroup of the phylum Chloroflexi. While members of this diverse group are consistently identified in the marine environment, there are currently no cultured representatives, and very little is known about their distribution or abundance in the world's oceans. In this study, published and newly identified SAR202-related 16S rRNA gene sequences were used to further resolve the phylogeny of this cluster and to design taxon-specific oligonucleotide probes for fluorescence in situ hybridization. Direct cell counts from the Bermuda Atlantic time series study site in the north Atlantic Ocean, the Hawaii ocean time series site in the central Pacific Ocean, and along the Newport hydroline in eastern Pacific coastal waters showed that SAR202 cluster cells were most abundant below the deep chlorophyll maximum and that they persisted to 3,600 m in the Atlantic Ocean and to 4,000 m in the Pacific Ocean, the deepest samples used in this study. On average, members of the SAR202 group accounted for 10.2% (±5.7%) of all DNA-containing bacterioplankton between 500 and 4,000 m. PMID:15128540

Pharmacogenetics in neuroendocrine tumors of the pancreas.

PubMed

Rizvi, Syed Mujtaba; Wong, Joyce; Saif, Muhammad Wasif; Jia, Yuxia

2014-07-28

Neuroendocrine tumors (NETs) arise from cells distributed throughout the endocrine system. Although, NETs are heterogeneous in their behavior, they tend to be more aggressive when arising in the pancreas. Pancreatic NET (panNET) represents three percent of all primary pancreatic neoplasms. Symptomatic and progressive panNETs are generally treated with cytotoxic chemotherapy, whereas molecular targeted therapy is used for nonfunctional tumors without aggressive features. Pharmacogenetics has increasingly been used recently to better identify potential targets for therapy and help select patient-specific therapy. In this review, we discuss two abstracts (Abstracts #4113 and #e15169) presented at the ASCO Annual Meeting in Chicago this year, outlining the potential role of tumor gene and gene product profiling in disease management. We describe what is known about the pathogenesis of these tumors, role of decreased gene product expression (MGMT, RRM1, MET) and its application in cytotoxic therapy selection, as well as genetic mutations that can be used for molecular targeted therapy. With an overall shift towards personalized medicine, it has become ever more important to identify the molecular signature of a tumor as it appears to dictate the clinical behavior and response to therapy.

Novel VEGF signalling inhibitors: how helpful are biomarkers in their early development?

PubMed

Wood, Joanna; Scott, Edwina; Thomas, Anne L

2009-11-01

The development of vascular endothelial growth factor (VEGF) inhibitors of tumour angiogenesis can only be described as prolific. It is therefore interesting to speculate which will reach the clinic. Of course, the most effective agents will succeed, but how is effectiveness measured? When presented with a summary of competitive compounds, it can be difficult to discriminate between their potency on target, toxicity and response rates. A comparison was undertaken between new small-molecule tyrosine kinase inhibitors with vascular endothelial growth factor receptor as one of their targets. Factors considered included mode of action (targets), toxicity and usefulness of biomarker data. We carried out a systematic review using PubMed, MEDLINE and American Society of Clinical Oncologist (ASCO) databases for articles (including abstracts) presented in 2007 - 2009. Search terms included 'angiogenesis inhibitors', 'tyrosine kinase inhibitors', 'VEGF' and 'biomarkers'. Nine compounds were selected for detailed comparison. The toxicity profiles of the compounds were similar. Many exposure biomarkers have been identified that have informed the dose and scheduling of these compounds in clinical trials. Progress has also been made in identifying potential efficacy and predictive biomarkers for these new agents; however, these are yet to be validated.

Vemurafenib: an evidence-based review of its clinical utility in the treatment of metastatic melanoma.

PubMed

Swaika, Abhisek; Crozier, Jennifer A; Joseph, Richard W

2014-01-01

The discovery of BRAF mutations in the majority of patients with metastatic melanoma combined with the identification of highly selective BRAF inhibitors have revolutionized the treatment of patients with metastatic melanoma. The first highly specific BRAF inhibitor, vemurafenib, began clinical testing in 2008 and moved towards a rapid approval in 2011. Vemurafenib induced responses in ~50% of patients with metastatic BRAF-mutant melanoma and demonstrated improved overall survival in a randomized Phase III trial. Furthermore, vemurafenib is well-tolerated with a low toxicity profile and rapid onset of action. Finally, vemurafenib is active even in patients with widely metastatic disease. Despite the success of vemurafenib in treating patients with BRAF-mutant metastatic melanoma, most, if not all, patients ultimately develop resistance resulting in disease progression at a median time of ~6 months. Multiple mechanisms of resistance have been described and rationale strategies are underway to combat resistance. This review highlights the development, clinical utility, resistance mechanisms, and future use of vemurafenib both in melanoma and other malignancies. We consulted PubMed, Scopus, MEDLINE, ASCO annual symposium abstracts, and http://clinicaltrials.gov/ for the purpose of this review.

Vemurafenib: an evidence-based review of its clinical utility in the treatment of metastatic melanoma

PubMed Central

Swaika, Abhisek; Crozier, Jennifer A; Joseph, Richard W

2014-01-01

The discovery of BRAF mutations in the majority of patients with metastatic melanoma combined with the identification of highly selective BRAF inhibitors have revolutionized the treatment of patients with metastatic melanoma. The first highly specific BRAF inhibitor, vemurafenib, began clinical testing in 2008 and moved towards a rapid approval in 2011. Vemurafenib induced responses in ~50% of patients with metastatic BRAF-mutant melanoma and demonstrated improved overall survival in a randomized Phase III trial. Furthermore, vemurafenib is well-tolerated with a low toxicity profile and rapid onset of action. Finally, vemurafenib is active even in patients with widely metastatic disease. Despite the success of vemurafenib in treating patients with BRAF-mutant metastatic melanoma, most, if not all, patients ultimately develop resistance resulting in disease progression at a median time of ~6 months. Multiple mechanisms of resistance have been described and rationale strategies are underway to combat resistance. This review highlights the development, clinical utility, resistance mechanisms, and future use of vemurafenib both in melanoma and other malignancies. We consulted PubMed, Scopus, MEDLINE, ASCO annual symposium abstracts, and http://clinicaltrials.gov/ for the purpose of this review. PMID:24966667

Salinity Processes in the Upper Ocean Regional Study (SPURS)

NASA Image and Video Library

2012-09-04

A full suite of instruments are seen onboard the the Woods Hole Oceanographic Institution research vessel Knorr on Tuesday, Sept. 4, 2012, in Woods Hole, Mass. The various instruments will be deployed in the Atlantic Ocean as part of the Salinity Processes in the Upper Ocean Regional Study (SPURS) which is set to sail on Sept. 6. The NASA-sponsored expedition will sail to the North Atlantic's saltiest spot to get a detailed, 3-D picture of how salt content fluctuates in the ocean's upper layers and how these variations are related to shifts in rainfall patterns around the planet. Photo Credit: (NASA/Bill Ingalls)

Salinity Processes in the Upper Ocean Regional Study (SPURS)

NASA Image and Video Library

2012-09-04

Autonomous wave gliders are seen onboard the the Woods Hole Oceanographic Institution research vessel Knorr on Tuesday, Sept. 4, 2012, in Woods Hole, Mass. The autonomous gliders will be deployed in the Atlantic Ocean as part of the Salinity Processes in the Upper Ocean Regional Study (SPURS) which is set to sail on Sept. 6. The NASA-sponsored expedition will sail to the North Atlantic's saltiest spot to get a detailed, 3-D picture of how salt content fluctuates in the ocean's upper layers and how these variations are related to shifts in rainfall patterns around the planet. Photo Credit: (NASA/Bill Ingalls)

Salinity Processes in the Upper Ocean Regional Study (SPURS)

NASA Image and Video Library

2012-09-04

University of Washington Graduate Student Jesse Anderson settles into her cabin onboard the Woods Hole Oceanographic Institution research vessel Knorr on Tuesday, Sept. 4, 2012, in Woods Hole, Mass. Anderson will work with the Argo Floats instruments in the Atlantic Ocean as part of the Salinity Processes in the Upper Ocean Regional Study (SPURS) which is set to sail on Sept. 6. The NASA-sponsored expedition will sail to the North Atlantic's saltiest spot to get a detailed, 3-D picture of how salt content fluctuates in the ocean's upper layers and how these variations are related to shifts in rainfall patterns around the planet. Photo Credit: (NASA/Bill Ingalls)

Salinity Processes in the Upper Ocean Regional Study (SPURS)

NASA Image and Video Library

2012-09-04

CTD instruments used to measure Conductivity, Temperature, and Depth, are seen onboard the Woods Hole Oceanographic Institution's research vessel Knorr on Tuesday, Sept. 4, 2012, in Woods Hole, Mass. The CTDs will be deployed in the Atlantic Ocean as part of the Salinity Processes in the Upper Ocean Regional Study (SPURS) which is set to sail on Sept. 6. The NASA-sponsored expedition will sail to the North Atlantic's saltiest spot to get a detailed, 3-D picture of how salt content fluctuates in the ocean's upper layers and how these variations are related to shifts in rainfall patterns around the planet. Photo Credit: (NASA/Bill Ingalls)

Salinity Processes in the Upper Ocean Regional Study (SPURS)

NASA Image and Video Library

2012-09-04

Autonomous wave gliders, right, are seen onboard the the Woods Hole Oceanographic Institution research vessel Knorr on Tuesday, Sept. 4, 2012, in Woods Hole, Mass. The autonomous gliders will be deployed in the Atlantic Ocean as part of the Salinity Processes in the Upper Ocean Regional Study (SPURS) which is set to sail on Sept. 6. The NASA-sponsored expedition will sail to the North Atlantic's saltiest spot to get a detailed, 3-D picture of how salt content fluctuates in the ocean's upper layers and how these variations are related to shifts in rainfall patterns around the planet. Photo Credit: (NASA/Bill Ingalls)

Salinity Processes in the Upper Ocean Regional Study (SPURS)

NASA Image and Video Library

2012-09-04

A sensor-laden buoy is seen prior to being loaded onboard the Woods Hole Oceanographic Institution's vessel Knorr on Tuesday, Sept. 4, 2012, in Woods Hole, Mass. The buoy will be deployed in the Atlantic Ocean as part of the Salinity Processes in the Upper Ocean Regional Study (SPURS) which is set to sail on Sept. 6. The NASA-sponsored expedition will sail to the North Atlantic's saltiest spot to get a detailed, 3-D picture of how salt content fluctuates in the ocean's upper layers and how these variations are related to shifts in rainfall patterns around the planet. Photo Credit: (NASA/Bill Ingalls)

Salinity Processes in the Upper Ocean Regional Study (SPURS)

NASA Image and Video Library

2012-09-04

Ken Decoteau, left, and Chip Beniot, both of the Woods Hole Oceanographic Institution, move scientific instruments to the research vessel Knorr on Tuesday, Sept. 4, 2012, in Woods Hole, Mass. The instruments will be deployed in the Atlantic Ocean as part of the Salinity Processes in the Upper Ocean Regional Study (SPURS) which is set to sail on Sept. 6. The NASA-sponsored expedition will sail to the North Atlantic's saltiest spot to get a detailed, 3-D picture of how salt content fluctuates in the ocean's upper layers and how these variations are related to shifts in rainfall patterns around the planet. Photo Credit: (NASA/Bill Ingalls)

Salinity Processes in the Upper Ocean Regional Study (SPURS)

NASA Image and Video Library

2012-09-04

Chip Beniot, left, and Ken Decoteau, both of the Woods Hole Oceanographic Institution, move scientific instruments to the research vessel Knorr on Tuesday, Sept. 4, 2012, in Woods Hole, Mass. The instruments will be deployed in the Atlantic Ocean as part of the Salinity Processes in the Upper Ocean Regional Study (SPURS) which is set to sail on Sept. 6. The NASA-sponsored expedition will sail to the North Atlantic's saltiest spot to get a detailed, 3-D picture of how salt content fluctuates in the ocean's upper layers and how these variations are related to shifts in rainfall patterns around the planet. Photo Credit: (NASA/Bill Ingalls)

Salinity Processes in the Upper Ocean Regional Study (SPURS)

NASA Image and Video Library

2012-09-04

NASA Physical Oceanography Program Scientist Eric Lindstrom talks about the instruments onboard the Woods Hole Oceanographic Institution research vessel Knorr on Tuesday, Sept. 4, 2012, in Woods Hole, Mass. Various scientific instruments will be deployed in the Atlantic Ocean as part of the Salinity Processes in the Upper Ocean Regional Study (SPURS) which is set to sail on Sept. 6. The NASA-sponsored expedition will sail to the North Atlantic's saltiest spot to get a detailed, 3-D picture of how salt content fluctuates in the ocean's upper layers and how these variations are related to shifts in rainfall patterns around the planet. Photo Credit: (NASA/Bill Ingalls)

Salinity Processes in the Upper Ocean Regional Study (SPURS)

NASA Image and Video Library

2012-09-04

NASA Physical Oceanography Program Scientist Eric Lindstrom inspects an autonomous wave glider onboard the Woods Hole Oceanographic Institution research vessel Knorr on Tuesday, Sept. 4, 2012, in Woods Hole, Mass. The autonomous gliders will be deployed in the Atlantic Ocean as part of the Salinity Processes in the Upper Ocean Regional Study (SPURS) which is set to sail on Sept. 6. The NASA-sponsored expedition will sail to the North Atlantic's saltiest spot to get a detailed, 3-D picture of how salt content fluctuates in the ocean's upper layers and how these variations are related to shifts in rainfall patterns around the planet. Photo Credit: (NASA/Bill Ingalls)

The Ocean Sampling Day Consortium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kopf, Anna; Bicak, Mesude; Kottmann, Renzo

In this study, Ocean Sampling Day was initiated by the EU-funded Micro B3 (Marine Microbial Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine microbial biodiversity and function of the world’s oceans. It is a simultaneous global mega-sequencing campaign aiming to generate the largest standardized microbial data set in a single day. This will be achievable only through the coordinated efforts of an Ocean Sampling Day Consortium, supportive partnerships and networks between sites. This commentary outlines the establishment, function and aims of the Consortium and describes our vision for a sustainable study of marine microbial communities and theirmore » embedded functional traits.« less

Salinity Processes in the Upper Ocean Regional Study (SPURS)

NASA Image and Video Library

2012-09-04

Woods Hole Oceanographic Institution Scientist Dave Fratantoni works on the EcoMapper AUVs (autonomous underwater vehicles) onboard the Institute's research vessel Knorr, Tuesday, Sept. 4, 2012, in Woods Hole, Mass. The EcoMappers will be deployed in the Atlantic Ocean as part of the Salinity Processes in the Upper Ocean Regional Study (SPURS) which is set to sail on Sept. 6. The NASA-sponsored expedition will sail to the North Atlantic's saltiest spot to get a detailed, 3-D picture of how salt content fluctuates in the ocean's upper layers and how these variations are related to shifts in rainfall patterns around the planet. Photo Credit: (NASA/Bill Ingalls)

Salinity Processes in the Upper Ocean Regional Study (SPURS)

NASA Image and Video Library

2012-09-04

Two EcoMapper AUVs (autonomous underwater vehicles) are seen onboard the the Woods Hole Oceanographic Institution research vessel Knorr on Tuesday, Sept. 4, 2012, in Woods Hole, Mass. The EcoMappers will be deployed in the Atlantic Ocean as part of the Salinity Processes in the Upper Ocean Regional Study (SPURS) which is set to sail on Sept. 6. The NASA-sponsored expedition will sail to the North Atlantic's saltiest spot to get a detailed, 3-D picture of how salt content fluctuates in the ocean's upper layers and how these variations are related to shifts in rainfall patterns around the planet. Photo Credit: (NASA/Bill Ingalls)

The Ocean Sampling Day Consortium

DOE PAGES

Kopf, Anna; Bicak, Mesude; Kottmann, Renzo; ...

2015-06-19

In this study, Ocean Sampling Day was initiated by the EU-funded Micro B3 (Marine Microbial Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine microbial biodiversity and function of the world’s oceans. It is a simultaneous global mega-sequencing campaign aiming to generate the largest standardized microbial data set in a single day. This will be achievable only through the coordinated efforts of an Ocean Sampling Day Consortium, supportive partnerships and networks between sites. This commentary outlines the establishment, function and aims of the Consortium and describes our vision for a sustainable study of marine microbial communities and theirmore » embedded functional traits.« less

Assessing preferences of beach users for certain aspects of weather and ocean conditions: case studies from Australia

NASA Astrophysics Data System (ADS)

Zhang, Fan; Wang, Xiao Hua

2013-05-01

Three well-known Australian beaches, Surfers Paradise Beach (Gold Coast), Narrowneck Beach (Gold Coast) and Bondi Beach (Sydney), were selected for analysis of beach user preferences for certain weather and ocean conditions. Regression methods were used to determine how the numbers of visitors to these beaches are affected by these conditions. Actual visitor numbers were counted at three times during the day over several months at each beach with the aid of web cameras. The corresponding weather and ocean conditions were obtained from the Australian Bureau of Meteorology and local government agencies. Weekly and seasonal factors were also considered. The conditions preferred by beach users, as found in this study, are: no precipitation, higher temperatures, light-to-moderate wind speed (less than 30 km/h) and low wave height (up to 1.25 m). This study, the first to provide an analysis of beach user preferences for both weather and ocean conditions, shows that ocean conditions play a significant role in explaining the demand for beach recreation in Australia. It is therefore necessary for tourism management authorities or local governments to provide accurate and timely weather and ocean information to local, domestic and international beach users.

Assessing preferences of beach users for certain aspects of weather and ocean conditions: case studies from Australia.

PubMed

Zhang, Fan; Wang, Xiao Hua

2013-05-01

Three well-known Australian beaches, Surfers Paradise Beach (Gold Coast), Narrowneck Beach (Gold Coast) and Bondi Beach (Sydney), were selected for analysis of beach user preferences for certain weather and ocean conditions. Regression methods were used to determine how the numbers of visitors to these beaches are affected by these conditions. Actual visitor numbers were counted at three times during the day over several months at each beach with the aid of web cameras. The corresponding weather and ocean conditions were obtained from the Australian Bureau of Meteorology and local government agencies. Weekly and seasonal factors were also considered. The conditions preferred by beach users, as found in this study, are: no precipitation, higher temperatures, light-to-moderate wind speed (less than 30 km/h) and low wave height (up to 1.25 m). This study, the first to provide an analysis of beach user preferences for both weather and ocean conditions, shows that ocean conditions play a significant role in explaining the demand for beach recreation in Australia. It is therefore necessary for tourism management authorities or local governments to provide accurate and timely weather and ocean information to local, domestic and international beach users.

An overview of the South Atlantic Ocean climate variability and air-sea interaction processes

NASA Astrophysics Data System (ADS)

Pezzi, L. P.; Parise, C. K.; Souza, R.; Gherardi, D. F.; Camargo, R.; Soares, H. C.; Silveira, I.

2013-05-01

The Ocean Modeling Group at the National Institute of Space Research (INPE) in Brazil has been developing several studies to understand the role of the Atlantic ocean on the South America climate. Studies include simulating the dynamics of the Tropical South-Atlantic Ocean and Southern Ocean. This is part of an ongoing international cooperation, in which Brazil participates with in situ observations, numerical modeling and statistical analyses. We have focused on the understanding of the impacts of extreme weather events over the Tropical South Atlantic Ocean and their prediction on different time-scales. One such study is aimed at analyzing the climate signal generated by imposing an extreme condition on the Antarctic sea ice and considering different complexities of the sea ice model. The influence of the Brazil-Malvinas Confluence (BMC) region on the marine atmospheric boundary layer (MABL) is also investigated through in situ data analysis of different cruises and numerical experiments with a regional numerical model. There is also an ongoing investigation that revealed basin-scale interannual climate variation with impacts on the Brazilian Large Marine Ecosystems (LMEs), which are strongly correlated with climate indices such as ENSO, AAO and PDO.

Real world ocean rogue waves explained without the modulational instability.

PubMed

Fedele, Francesco; Brennan, Joseph; Ponce de León, Sonia; Dudley, John; Dias, Frédéric

2016-06-21

Since the 1990s, the modulational instability has commonly been used to explain the occurrence of rogue waves that appear from nowhere in the open ocean. However, the importance of this instability in the context of ocean waves is not well established. This mechanism has been successfully studied in laboratory experiments and in mathematical studies, but there is no consensus on what actually takes place in the ocean. In this work, we question the oceanic relevance of this paradigm. In particular, we analyze several sets of field data in various European locations with various tools, and find that the main generation mechanism for rogue waves is the constructive interference of elementary waves enhanced by second-order bound nonlinearities and not the modulational instability. This implies that rogue waves are likely to be rare occurrences of weakly nonlinear random seas.

Real world ocean rogue waves explained without the modulational instability

PubMed Central

Fedele, Francesco; Brennan, Joseph; Ponce de León, Sonia; Dudley, John; Dias, Frédéric

2016-01-01

Since the 1990s, the modulational instability has commonly been used to explain the occurrence of rogue waves that appear from nowhere in the open ocean. However, the importance of this instability in the context of ocean waves is not well established. This mechanism has been successfully studied in laboratory experiments and in mathematical studies, but there is no consensus on what actually takes place in the ocean. In this work, we question the oceanic relevance of this paradigm. In particular, we analyze several sets of field data in various European locations with various tools, and find that the main generation mechanism for rogue waves is the constructive interference of elementary waves enhanced by second-order bound nonlinearities and not the modulational instability. This implies that rogue waves are likely to be rare occurrences of weakly nonlinear random seas. PMID:27323897

Studies of oceanic tectonics based on GEOS-3 satellite altimetry

NASA Technical Reports Server (NTRS)

Poehls, K. A.; Kaula, W. M.; Schubert, G.; Sandwell, D.

1979-01-01

Using statistical analysis, geoidal admittance (the relationship between the ocean geoid and seafloor topography) obtained from GEOS-3 altimetry was compared to various model admittances. Analysis of several altimetry tracks in the Pacific Ocean demonstrated a low coherence between altimetry and seafloor topography except where the track crosses active or recent tectonic features. However, global statistical studies using the much larger data base of all available gravimetry showed a positive correlation of oceanic gravity with topography. The oceanic lithosphere was modeled by simultaneously inverting surface wave dispersion, topography, and gravity data. Efforts to incorporate geoid data into the inversion showed that the base of the subchannel can be better resolved with geoid rather than gravity data. Thermomechanical models of seafloor spreading taking into account differing plate velocities, heat source distributions, and rock rheologies were discussed.

Identification of pixels with stray light and cloud shadow contaminations in the satellite ocean color data processing.

PubMed

Jiang, Lide; Wang, Menghua

2013-09-20

A new flag/masking scheme has been developed for identifying stray light and cloud shadow pixels that significantly impact the quality of satellite-derived ocean color products. Various case studies have been carried out to evaluate the performance of the new cloud contamination flag/masking scheme on ocean color products derived from the Visible Infrared Imaging Radiometer Suite (VIIRS) onboard the Suomi National Polar-orbiting Partnership (SNPP). These include direct visual assessments, detailed quantitative case studies, objective statistic analyses, and global image examinations and comparisons. The National Oceanic and Atmospheric Administration (NOAA) Multisensor Level-1 to Level-2 (NOAA-MSL12) ocean color data processing system has been used in the study. The new stray light and cloud shadow identification method has been shown to outperform the current stray light flag in both valid data coverage and data quality of satellite-derived ocean color products. In addition, some cloud-related flags from the official VIIRS-SNPP data processing software, i.e., the Interface Data Processing System (IDPS), have been assessed. Although the data quality with the IDPS flags is comparable to that of the new flag implemented in the NOAA-MSL12 ocean color data processing system, the valid data coverage from the IDPS is significantly less than that from the NOAA-MSL12 using the new stray light and cloud shadow flag method. Thus, the IDPS flag/masking algorithms need to be refined and modified to reduce the pixel loss, e.g., the proposed new cloud contamination flag/masking can be implemented in IDPS VIIRS ocean color data processing.

Customizing Process to Align with Purpose and Program: The 2003 MS PHD'S in Ocean Sciences Program Evaluative Case Study

NASA Astrophysics Data System (ADS)

Williamson, V. A.; Pyrtle, A. J.

2004-12-01

How did the 2003 Minorities Striving and Pursuing Higher Degrees of Success (MS PHD'S) in Ocean Sciences Program customize evaluative methodology and instruments to align with program goals and processes? How is data captured to document cognitive and affective impact? How are words and numbers utilized to accurately illustrate programmatic outcomes? How is compliance with implicit and explicit funding regulations demonstrated? The 2003 MS PHD'S in Ocean Sciences Program case study provides insightful responses to each of these questions. MS PHD'S was developed by and for underrepresented minorities to facilitate increased and sustained participation in Earth system science. Key components of this initiative include development of a community of scholars sustained by face-to-face and virtual mentoring partnerships; establishment of networking activities between and among undergraduate, graduate, postgraduate students, scientists, faculty, professional organization representatives, and federal program officers; and provision of forums to address real world issues as identified by each constituent group. The evaluative case study of the 2003 MS PHD'S in Ocean Sciences Program consists of an analysis of four data sets. Each data set was aligned to document progress in the achievement of the following program goals: Goal 1: The MS PHD'S Ocean Sciences Program will successfully market, recruit, select, and engage underrepresented student and non-student participants with interest/ involvement in Ocean Sciences; Goal 2: The MS PHD'S Ocean Sciences Program will provide meaningful engagement for participants as determined by quantitative analysis of user-feedback; Goal 3: The MS PHD'S Ocean Sciences Program will provide meaningful engagement for participants as determined by qualitative analysis of user-feedback, and; Goal 4: The MS PHD'S Ocean Sciences Program will develop a constituent base adequate to demonstrate evidence of interest, value, need and sustainability in its vision, mission, goals and activities. In addition to the documentation of evaluative process, the case study also provides insight on the establishment of mutually supportive principal investigator and evaluator partnerships as necessary foundations for building effective teams. The study addresses frequently asked questions (FAQ's) on the formation and sustenance of partnerships among visionaries and evaluators and the impact of this partnership on the achievement of program outcomes.

Evolution of Planetary Ice-Ocean Systems: Effects of Salinity

NASA Astrophysics Data System (ADS)

Allu Peddinti, D.; McNamara, A. K.

2015-12-01

Planetary oceanography is enjoying renewed attention thanks to not only the detection of several exoplanetary ocean worlds but also due to the expanding family of ocean worlds within our own star system. Our solar system is now believed to host about nine ocean worlds including Earth, some dwarf planets and few moons of Jupiter and Saturn. Amongst them, Europa, like Earth is thought to have an ice Ih-liquid water system. However, the thickness of the Europan ice-ocean system is much larger than that of the Earth. The evolution of this system would determine the individual thicknesses of the ice shell and the ocean. In turn, these thicknesses can alter the course of evolution of the system. In a pure H2O system, the thickness of the ice shell would govern if heat loss occurs entirely by conduction or if the shell begins to convect as it attains a threshold thickness. This switch between conduction-convection regimes could determine the longevity of the subsurface ocean and hence define the astrobiological potential of the planetary body at any given time. In reality, however, the system is not pure water ice. The detected induced magnetic field infers a saline ocean layer. Salts are expected to act as an anti-freeze allowing a subsurface ocean to persist over long periods but the amount of salts would determine the extent of that effect. In our current study, we use geodynamic models to examine the effect of salinity on the evolution of ice-ocean system. An initial ocean with different salinities is allowed to evolve. The effect of salinity on thickness of the two layers at any time is examined. We also track how salinity controls the switch between conductive-convective modes. The study shows that for a given time period, larger salinities can maintain a thick vigorously convecting ocean while the smaller salinities behave similar to a pure H2O system leading to a thick convecting ice-shell. A range of salinities identified can potentially predict the current state and possibly the intermediate states of the ice-ocean system as it evolved over time. This could help constrain the endogenic contribution of salts to the surface chemistry.

Upper-ocean Response to Hurricane Gonzalo (2014): Salinity Effects Revealed by Targeted and Sustained Underwater Glider Observation

NASA Astrophysics Data System (ADS)

Domingues, R. M.; Goni, G. J.; Bringas, F.; Lee, S. K.; Kim, H. S. S.; Halliwell, G. R., Jr.; Dong, J.; Morell, J. M.; Pomales, L.

2016-02-01

In July 2014, two underwater gliders were deployed off Puerto Rico as part of a multi-institutional effort lead by NOAA/AOML funded by the Disaster Appropriations Relief Act of 2013 known as Sandy Supplemental. The goal of this work is to collect ocean observations to: (1) investigate the response of the ocean to tropical cyclone (TC) wind conditions; (2) improve understanding on the role that the ocean plays in the intensification of TCs; and (3) help improve TC seasonal and intensity forecasts. The two gliders were piloted along predetermined tracks in the Caribbean Sea and in the North Atlantic Ocean (Figure 1), where TCs very often travel and intensify. On October 12, 2014, TC Gonzalo developed in the tropical North Atlantic, reaching the status of Category 3 hurricane on October 14 as it travelled 85 km northeast of the location of the glider (site B, Figure 1). The sampling strategy adopted during the passage of Hurricane Gonzalo consisted of carrying out observations: along a repeat section three times between sites A and B, one before and two after the passage of the hurricane; and at a fixed location at site B during the passage of the hurricane. Observations collected before, during, and after the passage of this hurricane were analyzed to improve our understanding of the upper-ocean response to hurricane winds. The main finding in this study is that salinity played an important role on the upper-ocean response to Hurricane Gonzalo; where a near-surface barrier-layer has likely suppressed the hurricane-induced upper-ocean cooling, leading to smaller than expected temperature changes of -0.4°C. Post-storm observations also revealed a partial recovery of the ocean to pre-storm conditions 11 days after the hurricane. Glider observations were further compared with outputs from a numerical coupled atmospheric-ocean model used for hurricane prediction to evaluate the model performance in simulating the upper-ocean response during Hurricane Gonzalo. The comparison revealed that model-observations discrepancies were largely linked to salinity effects. Results presented in this study emphasize the value of underwater glider observations for improving our knowledge of how the ocean responds to tropical cyclone winds and for tropical cyclone intensification studies and forecasts.

Optical Measurements and Modeling to Estimate Concentrations and Fluxes of Organic Matter in the Southern Ocean

NASA Technical Reports Server (NTRS)

Stramski, Dariusz; Mitchell, B. Greg; Marra, John W. (Technical Monitor)

2001-01-01

This project was a collaboration between two Principal Investigators, Dr. Dariusz Stramski and Dr. Greg Mitchell of Scripps Institution of Oceanography, University of California San Diego. Our overall goal was to conduct optical measurements and modeling to estimate concentrations of organic matter in the Southern Ocean in support of the U.S. JGOFS Process Study in this region. Key variables and processes of high relevance to accomplish the JGOFS goals include time and space resolution of phytoplankton pigments, particulate organic carbon, and the formation and export of organic carbon. Our project focused on establishing the fundamental relationships for parameterization of these variables and processes in terms of the optical properties of seawater, and developing understanding of why the Southern Ocean differs from other low-latitude systems, or has differentiation within. Our approach builds upon historical observations that optical properties provide a useful proxy for key reservoirs of organic matter such as chlorophyll alpha (Chl) and particulate organic carbon (POC) concentrations, which are of relevance to the JGOFS objectives. We carried out detailed studies of in situ and water sample optical properties including spectral reflectance, absorption, beam attenuation, scattering, and backscattering coefficients. We evaluated the ability to estimate Chl from the spectral reflectance (ocean color) in the Southern Ocean. We examined relationships between the ocean optical properties and particulate organic carbon. We developed, for the first time, an algorithm for estimating particulate organic carbon concentration in the surface ocean from satellite imagery of ocean color. With this algorithm, we obtained maps of POC distribution in the Southern Ocean showing the seasonal progression of POC in the austral spring-summer season. We also developed a semianalytical reflectance model for the investigated polar waters based on our field measurements of absorption and backscattering coefficients and Chl-dependent parameterizations of these coefficients. With this model, libraries of expected reflectance spectra for various chlorophyll concentrations can be generated with high spectral resolution for specific oceanic regions. In addition, our semianalytical reflectance model provided insight into the mechanisms which drive the empirical relationships between the ocean color and chlorophyll concentration. Our optical approach to the study of pigment and carbon concentrations will be directly relevant to development of system models and long-term monitoring of the Southern Ocean.

Anomalous Variation in GPS TEC, Land and Ocean Parameters Prior to 3 Earthquakes

NASA Astrophysics Data System (ADS)

Yadav, Kunvar; Karia, Sheetal P.; Pathak, Kamlesh N.

2016-02-01

The present study reports the analysis of GPS TEC prior to 3 earthquakes ( M > 6.0). The earthquakes are: (1) Loyalty Island (22°36'S, 170°54'E) on 19 January 2009 ( M = 6.6), (2) Samoa Island (15°29'S, 172°5'W) on 30 August 2009 ( M = 6.6), and (3) Tohoku (38°19'N, 142°22'E) on 11 March 2011 ( M = 9.0). In an effort to search for a precursory signature we analysed the land and ocean parameters prior to the earthquakes, namely SLHF (Land) and SST (Ocean). The GPS TEC data indicate an anomalous behaviour from 1-13 days prior to earthquakes. The main purpose of this study was to explore and demonstrate the possibility of any changes in TEC, SST, and SLHF before, during and after the earthquakes which occurred near or beneath an ocean. This study may lead to better understanding of response of land, ocean, and ionosphere parameters prior to seismic activities.

An Auto-Photographic Study of Undergraduate Students' Conceptions of Ocean Sustainability

ERIC Educational Resources Information Center

Lin, Chi-I; Li, Yuh-Yuh

2017-01-01

Purpose: The purpose of this paper is to investigate students' understandings of ocean sustainability and the pedagogical influence of higher education on those conceptions. Design/methodology/approach: The conceptions of ocean sustainability of 54 university students of various academic disciplines enrolled in the 2014/2015 semester course…

Evaluation of High Resolution IMERG Satellite Precipitation over the Global Oceans using OceanRAIN

NASA Astrophysics Data System (ADS)

Kucera, P. A.; Klepp, C.

2017-12-01

Precipitation is a key parameter of the essential climate variables in the Earth System that is a key variable in the global water cycle. Observations of precipitation over oceans is relatively sparse. Satellite observations over oceans is the only viable means of measuring the spatially distribution of precipitation. In an effort to improve global precipitation observations, the research community has developed a state of the art precipitation dataset as part of the NASA/JAXA Global Precipitation Measurement (GPM) program. The satellite gridded product that has been developed is called Integrated Multi-satelliE Retrievals for GPM (IMERG), which has a maximum spatial resolution of 0.1º x 0.1º and temporal 30 minute. Even with the advancements in retrievals, there is a need to quantify uncertainty of IMERG precipitation estimates especially over oceans. To address this need, the OceanRAIN dataset has been used to create a comprehensive database to compare IMERG products. The OceanRAIN dataset was created using observations from the ODM-470 optical disdrometer that has been deployed on 12 research vessels worldwide with 6 long-term installations operating in all climatic regions, seasons and ocean basins. More than 6 million data samples have been collected on the OceanRAIN program. These data were matched to IMERG grids for the study period of 15 March 2014-01 April 2017. This evaluation produced over 1500 matched IMERG-OceanRAIN pairs of precipitation observed at the surface. These matched pairs were used to evaluate the performance of IMERG stratified by different latitudinal bands and precipitation regimes. The presentation will provide an overview of the study and summary of evaluation results.

The Bidirectional Reflectance Distribution Function (BRDF) of the Ocean: Effects of Wave Representation

NASA Astrophysics Data System (ADS)

Eide, H.; Stamnes, K.; Ottaviani, M.

2004-12-01

The specular reflection of the Sun off the ocean, or sun glint, is of major concern for ocean remote sensing. Typically, data from in and around the sunglint region are discarded because of the unknown contribution to the measured radiances or because of sensor saturation. On the other hand, accurate knowledge of the sunglint properties enables retrievals of atmospheric parameters. The challenge of the ocean retrieval problem is to get the ``water leaving radiance'', Lw, by subtracting the Rayleigh scattering, aerosol scattering, water vapor, ozone, and sun glint from the measured radiances at the top of the atmosphere (TOA). Thus, the task is to correct for both the atmospheric contribution and for surface effects. Two simplifying assumptions that are frequently employed in ocean remote sensing are that the ocean BRDF is isotropic and that one can de-couple the radiative properties of the atmosphere from those of the surface. Our previous studies have shown that neglecting the inherit coupling between the atmosphere and surface can lead to large errors in the retrievals. In order to do retrievals over bright, as well as darker surfaces, it is necessary to account for this coupling between the surface and the atmosphere. In the present study we use models for the reflection of light off the ocean surface to calculate the ocean BRDF. The differences between the various models are investigated as is the effect of using different types of wave statistics (e.g. Cox Munk). We present results from calculations where we vary the wind speed and direction as well as other parameters affecting the ocean surface. The error introduced in ocean retrievals by assuming an isotropic BRDF is assessed, and methods for improved treatment of sunglint are suggested.

Constraining global air-sea gas exchange for CO2 with recent bomb 14C measurements

NASA Astrophysics Data System (ADS)

Sweeney, Colm; Gloor, Emanuel; Jacobson, Andrew R.; Key, Robert M.; McKinley, Galen; Sarmiento, Jorge L.; Wanninkhof, Rik

2007-06-01

The 14CO2 released into the stratosphere during bomb testing in the early 1960s provides a global constraint on air-sea gas exchange of soluble atmospheric gases like CO2. Using the most complete database of dissolved inorganic radiocarbon, DI14C, available to date and a suite of ocean general circulation models in an inverse mode we recalculate the ocean inventory of bomb-produced DI14C in the global ocean and confirm that there is a 25% decrease from previous estimates using older DI14C data sets. Additionally, we find a 33% lower globally averaged gas transfer velocity for CO2 compared to previous estimates (Wanninkhof, 1992) using the NCEP/NCAR Reanalysis 1 1954-2000 where the global mean winds are 6.9 m s-1. Unlike some earlier ocean radiocarbon studies, the implied gas transfer velocity finally closes the gap between small-scale deliberate tracer studies and global-scale estimates. Additionally, the total inventory of bomb-produced radiocarbon in the ocean is now in agreement with global budgets based on radiocarbon measurements made in the stratosphere and troposphere. Using the implied relationship between wind speed and gas transfer velocity ks = 0.27(Sc/660)-0.5 and standard partial pressure difference climatology of CO2 we obtain an net air-sea flux estimate of 1.3 ± 0.5 PgCyr-1 for 1995. After accounting for the carbon transferred from rivers to the deep ocean, our estimate of oceanic uptake (1.8 ± 0.5 PgCyr-1) compares well with estimates based on ocean inventories, ocean transport inversions using ocean concentration data, and model simulations.

Evaluation of radiative fluxes over the north Indian Ocean

NASA Astrophysics Data System (ADS)

Ramesh Kumar, M. R.; Pinker, Rachel T.; Mathew, Simi; Venkatesan, R.; Chen, W.

2018-05-01

Radiative fluxes are a key component of the surface heat budget of the oceans. Yet, observations over oceanic region are sparse due to the complexity of radiation measurements; moreover, certain oceanic regions are substantially under-sampled, such as the north Indian Ocean. The National Institute of Ocean Technology, Chennai, India, under its Ocean Observation Program has deployed an Ocean Moored Network for the Northern Indian Ocean (OMNI) both in the Arabian Sea and the Bay of Bengal. These buoys are equipped with sensors to measure radiation and rainfall, in addition to other basic meteorological parameters. They are also equipped with sensors to measure sub-surface currents, temperature, and conductivity from the surface up to a depth of 500 m. Observations from the Moderate Resolution Imaging Spectroradiometer (MODIS) sensor onboard the National Aeronautics and Space Administration (NASA) AQUA and TERRA satellites have been used to infer surface radiation over the north Indian Ocean. In this study, we focus only on the shortwave (SW↓) fluxes. The evaluations of the MODIS-based SW↓ fluxes against the RAMA observing network have shown a very good agreement between them, and therefore, we use the MODIS-derived fluxes as a reference for the evaluation of the OMNI observations. In an early deployment of the OMNI buoys, the radiation sensors were placed at 2 m above the sea surface; subsequently, the height of the sensors was raised to 3 m. In this study, we show that there was a substantial improvement in the agreement between the buoy observations and the satellite estimates, once the sensors were raised to higher levels. The correlation coefficient increased from 0.87 to 0.93, and both the bias and standard deviations decreased substantially.

Intraseasonal variability of upper-ocean currents and photosynthetic primary production along the U.S. west coast associated with the Madden-Julian Oscillation

NASA Astrophysics Data System (ADS)

Barrett, B.; Davies, A. R.; Steppe, C. N.; Hackbarth, C.

2017-12-01

In the first part of this study, time-lagged composites of upper-ocean currents from February to May of 1993-2016 were binned by active phase of the leading atmospheric mode of intraseasonal variability, the Madden-Julian Oscillation (MJO). Seven days after the convectively active phase of the MJO enters the tropical Indian Ocean, anomalously strong south-southeastward upper-ocean currents are observed along the majority of U.S. west coast. Seven days after the convectively active phase enters the tropical western Pacific Ocean, upper-ocean current anomalies reverse along the U.S. west coast, with weaker southward flow. A physical pathway to the ocean was found for both of these: (a) tropical MJO convection modulates upper-tropospheric heights and circulation over the Pacific Ocean; (b) those anomalous atmospheric heights adjust the strength and position of the Aleutian Low and Hawaiian High; (c) surface winds change in response to the adjusted atmospheric pressure patterns; and (d) those surface winds project onto upper-ocean currents. In the second part of this study, we investigated if the MJO modulated intraseasonal variability of surface wind forcing and upper-ocean currents projected onto phytoplankton abundance along the U.S. west coast. Following a similar methodology, time-lagged, level 3 chlorophyll-a satellite products (a proxy for photosynthetic primary production) were binned by active MJO phase and analyzed for statistical significance using the Student's t test. Results suggest that intraseasonal variability of biological production along the U.S. west coast may be linked to the MJO, particularly since the time scale of the life cycle of phytoplankton is similar to the time scale of the MJO.

Deep ocean communities impacted by changing climate over 24 y in the abyssal northeast Pacific Ocean.

PubMed

Smith, Kenneth L; Ruhl, Henry A; Kahru, Mati; Huffard, Christine L; Sherman, Alana D

2013-12-03

The deep ocean, covering a vast expanse of the globe, relies almost exclusively on a food supply originating from primary production in surface waters. With well-documented warming of oceanic surface waters and conflicting reports of increasing and decreasing primary production trends, questions persist about how such changes impact deep ocean communities. A 24-y time-series study of sinking particulate organic carbon (food) supply and its utilization by the benthic community was conducted in the abyssal northeast Pacific (~4,000-m depth). Here we show that previous findings of food deficits are now punctuated by large episodic surpluses of particulate organic carbon reaching the sea floor, which meet utilization. Changing surface ocean conditions are translated to the deep ocean, where decadal peaks in supply, remineralization, and sequestration of organic carbon have broad implications for global carbon budget projections.

Does Southern Ocean Surface Forcing Shape the Global Ocean Overturning Circulation?

NASA Astrophysics Data System (ADS)

Sun, Shantong; Eisenman, Ian; Stewart, Andrew L.

2018-03-01

Paleoclimate proxy data suggest that the Atlantic Meridional Overturning Circulation (AMOC) was shallower at the Last Glacial Maximum (LGM) than its preindustrial (PI) depth. Previous studies have suggested that this shoaling necessarily accompanies Antarctic sea ice expansion at the LGM. Here the influence of Southern Ocean surface forcing on the AMOC depth is investigated using ocean-only simulations from a state-of-the-art climate model with surface forcing specified from the output of previous coupled PI and LGM simulations. In contrast to previous expectations, we find that applying LGM surface forcing in the Southern Ocean and PI surface forcing elsewhere causes the AMOC to shoal only about half as much as when LGM surface forcing is applied globally. We show that this occurs because diapycnal mixing renders the Southern Ocean overturning circulation more diabatic than previously assumed, which diminishes the influence of Southern Ocean surface buoyancy forcing on the depth of the AMOC.

A new simple concept for ocean colour remote sensing using parallel polarisation radiance

PubMed Central

He, Xianqiang; Pan, Delu; Bai, Yan; Wang, Difeng; Hao, Zengzhou

2014-01-01

Ocean colour remote sensing has supported research on subjects ranging from marine ecosystems to climate change for almost 35 years. However, as the framework for ocean colour remote sensing is based on the radiation intensity at the top-of-atmosphere (TOA), the polarisation of the radiation, which contains additional information on atmospheric and water optical properties, has largely been neglected. In this study, we propose a new simple concept to ocean colour remote sensing that uses parallel polarisation radiance (PPR) instead of the traditional radiation intensity. We use vector radiative transfer simulation and polarimetric satellite sensing data to demonstrate that using PPR has two significant advantages in that it effectively diminishes the sun glint contamination and enhances the ocean colour signal at the TOA. This concept may open new doors for ocean colour remote sensing. We suggest that the next generation of ocean colour sensors should measure PPR to enhance observational capability. PMID:24434904

Deep ocean communities impacted by changing climate over 24 y in the abyssal northeast Pacific Ocean

PubMed Central

Smith, Kenneth L.; Ruhl, Henry A.; Kahru, Mati; Huffard, Christine L.; Sherman, Alana D.

2013-01-01

The deep ocean, covering a vast expanse of the globe, relies almost exclusively on a food supply originating from primary production in surface waters. With well-documented warming of oceanic surface waters and conflicting reports of increasing and decreasing primary production trends, questions persist about how such changes impact deep ocean communities. A 24-y time-series study of sinking particulate organic carbon (food) supply and its utilization by the benthic community was conducted in the abyssal northeast Pacific (∼4,000-m depth). Here we show that previous findings of food deficits are now punctuated by large episodic surpluses of particulate organic carbon reaching the sea floor, which meet utilization. Changing surface ocean conditions are translated to the deep ocean, where decadal peaks in supply, remineralization, and sequestration of organic carbon have broad implications for global carbon budget projections. PMID:24218565

Trace elements in ocean ridge basalts

NASA Technical Reports Server (NTRS)

Kay, R. W.; Hubbard, N. J.

1978-01-01

A study is made of the trace elements found in ocean ridge basalts. General assumptions regarding melting behavior, trace element fractionation, and alteration effects are presented. Data on the trace elements are grouped according to refractory lithophile elements, refractory siderophile elements, and volatile metals. Variations in ocean ridge basalt chemistry are noted both for regional and temporal characteristics. Ocean ridge basalts are compared to other terrestrial basalts, such as those having La/Yb ratios greater than those of chondrites, and those having La/Yb ratios less than those of chondrites. It is found that (1) as compared to solar or chondrite ratios, ocean ridge basalts have low ratios of large, highly-charged elements to smaller less highly-charged elements, (2) ocean ridge basalts exhibit low ratios of volatile to nonvolatile elements, and (3) the transition metals Cr through Zn in ocean ridge basalts are not fractionated more than a factor of 2 or 3 from the chondritic abundance ratios.

Benzo[a]pyrene exposure under future ocean acidification scenarios weakens the immune responses of blood clam, Tegillarca granosa.

PubMed

Su, Wenhao; Zha, Shanjie; Wang, Yichen; Shi, Wei; Xiao, Guoqiang; Chai, Xueliang; Wu, Hongxi; Liu, Guangxu

2017-04-01

Persistent organic pollutants (POPs) are known to converge into the ocean and accumulate in the sediment, posing great threats to marine organisms such as the sessile bottom burrowing bivalves. However, the immune toxicity of POPs, such as B[a]P, under future ocean acidification scenarios remains poorly understood to date. Therefore, in the present study, the impacts of B[a]P exposure on the immune responses of a bivalve species, Tegillarca granosa, under present and future ocean acidification scenarios were investigated. Results obtained revealed an increased immune toxicity of B[a]P under future ocean acidification scenarios in terms of reduced THC, altered haemocyte composition, and hampered phagocytosis, which may attribute to the synergetic effects of B[a]P and ocean acidification. In addition, the gene expressions of pathogen pattern recognition receptors (TLR1, TLR2, TLR4, TLR6), pathway mediators (TRAF6, TAK1, TAB2, IKKα and Myd88), and effectors (NF-ĸB) of the important immune related pathways were significantly down-regulated upon exposure to B[a]P under future ocean acidification scenarios. Results of the present study suggested an increased immune toxicity of B[a]P under future ocean acidification scenarios, which will significantly hamper the immune responses of T. granosa and subsequently render individuals more susceptible to pathogens challenges. Copyright © 2017 Elsevier Ltd. All rights reserved.

Jason 1 Investigation: Altimetric Studies of Ocean Tidal Dynamics

NASA Technical Reports Server (NTRS)

Egbert, Gary D.

2004-01-01

Two papers on tidal dissipation were completed and published. The first of these extended our earlier work, which focused on the dominant M2 constituent, to include 7 additional constituents. In addition to confirming a total deep water dissipation total very close to 1 TW, this study demonstrated significant differences in the distribution of dissipation between diurnal and semi-diurnal constituents. The second paper involved an extensive modeling study of tides in the present day and the last glacial maximum. In this study we showed that accuracy of tidal solutions for the present day Ocean were significantly improved by including a parameterization of internal tide drag over rough topography in the deep ocean. It was also demonstrated that a complete self-consistent treatment of Ocean self attraction and tidal loading was required for accurate solutions.

Interannual to Decadal SST Variability in the Tropical Indian Ocean

NASA Astrophysics Data System (ADS)

Wang, G.; Newman, M.; Han, W.

2017-12-01

The Indian Ocean has received increasing attention in recent years for its large impacts on regional and global climate. However, due mainly to the close interdependence of the climate variation within the Tropical Pacific and the Indian Ocean, the internal sea surface temperature (SST) variability within the Indian Ocean has not been studied extensively on longer time scales. In this presentation we will show analysis of the interannual to decadal SST variability in the Tropical Indian Ocean in observations and Linear Inverse Model (LIM) results. We also compare the decoupled Indian Ocean SST variability from the Pacific against fully coupled one based on LIM integrations, to test the factors influence the features of the leading SST modes in the Indian Ocean. The result shows the Indian Ocean Basin (IOB) mode, which is strongly related to global averaged SST variability, passively responses to the Pacific variation. Without tropical Indo-Pacific coupling interaction, the intensity of IOB significantly decreases by 80%. The Indian Ocean Dipole (IOD) mode demonstrates its independence from the Pacific SST variability since the IOD does not change its long-term characteristics at all without inter-basin interactions. The overall SSTA variance decreases significantly in the Tropical Indian Ocean in the coupling restricted LIM runs, especially when the one-way impact from the Pacific to the Indian Ocean is turned off, suggesting that most of the variability in the Indian Ocean comes from the Pacific influence. On the other hand, the Indian Ocean could also transport anomalies to the Pacific, making the interaction a complete two-way process.

Decline in global oceanic oxygen content during the past five decades.

PubMed

Schmidtko, Sunke; Stramma, Lothar; Visbeck, Martin

2017-02-15

Ocean models predict a decline in the dissolved oxygen inventory of the global ocean of one to seven per cent by the year 2100, caused by a combination of a warming-induced decline in oxygen solubility and reduced ventilation of the deep ocean. It is thought that such a decline in the oceanic oxygen content could affect ocean nutrient cycles and the marine habitat, with potentially detrimental consequences for fisheries and coastal economies. Regional observational data indicate a continuous decrease in oceanic dissolved oxygen concentrations in most regions of the global ocean, with an increase reported in a few limited areas, varying by study. Prior work attempting to resolve variations in dissolved oxygen concentrations at the global scale reported a global oxygen loss of 550 ± 130 teramoles (10 12  mol) per decade between 100 and 1,000 metres depth based on a comparison of data from the 1970s and 1990s. Here we provide a quantitative assessment of the entire ocean oxygen inventory by analysing dissolved oxygen and supporting data for the complete oceanic water column over the past 50 years. We find that the global oceanic oxygen content of 227.4 ± 1.1 petamoles (10 15  mol) has decreased by more than two per cent (4.8 ± 2.1 petamoles) since 1960, with large variations in oxygen loss in different ocean basins and at different depths. We suggest that changes in the upper water column are mostly due to a warming-induced decrease in solubility and biological consumption. Changes in the deeper ocean may have their origin in basin-scale multi-decadal variability, oceanic overturning slow-down and a potential increase in biological consumption.

Evaluating the Impact of Changes in Oceanic Dissolved Oxygen on Marine Nitrous Oxide

NASA Astrophysics Data System (ADS)

Suntharalingam, Parvadha; Buitenhuis, Erik; Schmidtko, Sunke; Andrews, Oliver; LeQuere, Corinne

2013-04-01

Emissions of the greenhouse gas nitrous-oxide (N2O) from oceanic oxygen minimum zones (OMZs) in the Equatorial Pacific and Northwest Indian Ocean are believed to provide a significant portion of the global oceanic flux to the atmosphere. Mechanisms of marine N2O production and consumption in these regions display significant sensitivity to ambient oxygen, with high yields at low oxygen levels (O2 < 50 micromol/L), and N2O depletion via denitrification in anoxic zones. These OMZ regions display large gradients in sub-surface N2O, and high rates of N2O turnover that far exceed those observed in the open ocean. Recent studies have suggested that possible expansion of oceanic OMZs in a warming climate, could lead to significant changes in N2O emissions from these zones. In this analysis we employ a global ocean biogeochemistry model (NEMO-PlankTOM), which includes representation of the marine N2O cycle, to explore the impact of changes in dissolved oxygen on the ocean-atmosphere N2O flux. We focus on the period 1960-2000, and evaluate the impact of estimated changes in ocean oxygen from two alternative sources : (a) the observationally-based upper-ocean oxygen distributions and trends of Stramma et al. [2012]; (b) simulated oxygen distributions and temporal variations from a set of CMIP5 Earth System models. We will inter-compare the oceanic N2O estimates derived from these alternative scenarios of ocean de-oxygenation. We will also discuss the implications of our results for the ability to reliably predict changes in N2O emissions under potential expansion of oceanic OMZs, particularly in view of the recently noted discrepancies between observed and modeled trends in oceanic oxygen by Stramma et al. [2012].

Oceanic dispersion of Fukushima-derived Cs-137 in the coastal, offshore, and open oceans simulated by multiple oceanic general circulation models

NASA Astrophysics Data System (ADS)

Kawamura, H.; Furuno, A.; Kobayashi, T.; In, T.; Nakayama, T.; Ishikawa, Y.; Miyazawa, Y.; Usui, N.

2017-12-01

To understand the concentration and amount of Fukushima-derived Cs-137 in the ocean, this study simulates the oceanic dispersion of Cs-137 by an oceanic dispersion model SEA-GEARN-FDM developed at Japan Atomic Energy Agency (JAEA) and multiple oceanic general circulation models. The Cs-137 deposition amounts at the sea surface were used as the source term in oceanic dispersion simulations, which were estimated by atmospheric dispersion simulations with a Worldwide version of System for Prediction of Environmental Emergency Dose Information version II (WSPEEDI-II) developed at JAEA. The direct release from the Fukushima Daiichi Nuclear Power Plant into the ocean based on in situ Cs-137 measurements was used as the other source term in oceanic dispersion simulations. The simulated air Cs-137 concentrations qualitatively replicated those measured around the North Pacific. The accumulated Cs-137 ground deposition amount in the eastern Japanese Islands was consistent with that estimated by aircraft measurements. The oceanic dispersion simulations relatively well reproduced the measured Cs-137 concentrations in the coastal and offshore oceans during the first few months after the Fukushima disaster, and in the open ocean during the first year post-disaster. It was suggested that Cs-137 dispersed along the coast in the north-south direction during the first few months post-disaster, and were subsequently dispersed offshore by the Kuroshio Current and Kuroshio Extension. Mesoscale eddies accompanied by the Kuroshio Current and Kuroshio Extension played an important role in dilution of Cs-137. The Cs-137 amounts were quantified in the coastal, offshore, and open oceans during the first year post-disaster. It was demonstrated that Cs-137 actively dispersed from the coastal and offshore oceans to the open ocean, and from the surface layer to the deeper layer in the North Pacific.

Comparison of Oceanic and Continental Lithosphere, Asthenosphere, and the LAB Through Shear Velocity Inversion of Rayleigh Wave Data from the ALBACORE Amphibious Array in Southern California

NASA Astrophysics Data System (ADS)

Amodeo, K.; Rathnayaka, S.; Weeraratne, D. S.; Kohler, M. D.

2016-12-01

Continental and oceanic lithosphere, which form in different tectonic environments, are studied in a single amphibious seismic array across the Southern California continental margin. This provides a unique opportunity to directly compare oceanic and continental lithosphere, asthenosphere, and the LAB (Lithosphere-Asthenosphere Boundary) in a single data set. The complex history of the region, including spreading center subduction, block rotation, and Borderland extension, allows us to study limits in the rigidity and strength of the lithosphere. We study Rayleigh wave phase velocities obtained from the ALBACORE (Asthenospheric and Lithospheric Broadband Architecture from the California Offshore Region Experiment) offshore seismic array project and invert for shear wave velocity structure as a function of depth. We divide the study area into several regions: continent, inner Borderland, outer Borderland, and oceanic seafloor categorized by age. A unique starting Vs model is used for each case including layer thicknesses, densities, and P and S velocities which predicts Rayleigh phase velocities and are compared to observed phase velocities in each region. We solve for shear wave velocities with the best fit between observed and predicted phase velocity data in a least square sense. Preliminary results indicate that lithospheric velocities in the oceanic mantle are higher than the continental region by at least 2%. The LAB is observed at 50 ± 20 km beneath 15-35 Ma oceanic seafloor. Asthenospheric low velocities reach a minimum of 4.2 km/s in all regions, but have a steeper positive velocity gradient at the base of the oceanic asthenosphere compared to the continent. Seismic tomography images in two and three dimensions will be presented from each study region.

Effects of seawater acidification on gene expression: resolving broader-scale trends in sea urchins.

PubMed

Evans, Tyler G; Watson-Wynn, Priscilla

2014-06-01

Sea urchins are ecologically and economically important calcifying organisms threatened by acidification of the global ocean caused by anthropogenic CO2 emissions. Propelled by the sequencing of the purple sea urchin (Strongylocentrotus purpuratus) genome, profiling changes in gene expression during exposure to high pCO2 seawater has emerged as a powerful and increasingly common method to infer the response of urchins to ocean change. However, analyses of gene expression are sensitive to experimental methodology, and comparisons between studies of genes regulated by ocean acidification are most often made in the context of major caveats. Here we perform meta-analyses as a means of minimizing experimental discrepancies and resolving broader-scale trends regarding the effects of ocean acidification on gene expression in urchins. Analyses across eight studies and four urchin species largely support prevailing hypotheses about the impact of ocean acidification on marine calcifiers. The predominant expression pattern involved the down-regulation of genes within energy-producing pathways, a clear indication of metabolic depression. Genes with functions in ion transport were significantly over-represented and are most plausibly contributing to intracellular pH regulation. Expression profiles provided extensive evidence for an impact on biomineralization, epitomized by the down-regulation of seven spicule matrix proteins. In contrast, expression profiles provided limited evidence for CO2-mediated developmental delay or induction of a cellular stress response. Congruence between studies of gene expression and the ocean acidification literature in general validates the accuracy of gene expression in predicting the consequences of ocean change and justifies its continued use in future studies. © 2014 Marine Biological Laboratory.

Investigation of land ice-ocean interaction with a fully coupled ice-ocean model: 1. Model description and behavior

NASA Astrophysics Data System (ADS)

Goldberg, D. N.; Little, C. M.; Sergienko, O. V.; Gnanadesikan, A.; Hallberg, R.; Oppenheimer, M.

2012-06-01

Antarctic ice shelves interact closely with the ocean cavities beneath them, with ice shelf geometry influencing ocean cavity circulation, and heat from the ocean driving changes in the ice shelves, as well as the grounded ice streams that feed them. We present a new coupled model of an ice stream-ice shelf-ocean system that is used to study this interaction. The model is capable of representing a moving grounding line and dynamically responding ocean circulation within the ice shelf cavity. Idealized experiments designed to investigate the response of the coupled system to instantaneous increases in ocean temperature show ice-ocean system responses on multiple timescales. Melt rates and ice shelf basal slopes near the grounding line adjust in 1-2 years, and downstream advection of the resulting ice shelf thinning takes place on decadal timescales. Retreat of the grounding line and adjustment of grounded ice takes place on a much longer timescale, and the system takes several centuries to reach a new steady state. During this slow retreat, and in the absence of either an upward-or downward-sloping bed or long-term trends in ocean heat content, the ice shelf and melt rates maintain a characteristic pattern relative to the grounding line.

Microbial Ecology of the Dark Ocean above, at, and below the Seafloor†

PubMed Central

Orcutt, Beth N.; Sylvan, Jason B.; Knab, Nina J.; Edwards, Katrina J.

2011-01-01

Summary: The majority of life on Earth—notably, microbial life—occurs in places that do not receive sunlight, with the habitats of the oceans being the largest of these reservoirs. Sunlight penetrates only a few tens to hundreds of meters into the ocean, resulting in large-scale microbial ecosystems that function in the dark. Our knowledge of microbial processes in the dark ocean—the aphotic pelagic ocean, sediments, oceanic crust, hydrothermal vents, etc.—has increased substantially in recent decades. Studies that try to decipher the activity of microorganisms in the dark ocean, where we cannot easily observe them, are yielding paradigm-shifting discoveries that are fundamentally changing our understanding of the role of the dark ocean in the global Earth system and its biogeochemical cycles. New generations of researchers and experimental tools have emerged, in the last decade in particular, owing to dedicated research programs to explore the dark ocean biosphere. This review focuses on our current understanding of microbiology in the dark ocean, outlining salient features of various habitats and discussing known and still unexplored types of microbial metabolism and their consequences in global biogeochemical cycling. We also focus on patterns of microbial diversity in the dark ocean and on processes and communities that are characteristic of the different habitats. PMID:21646433

Exploring the functional side of the Ocean Sampling Day metagenomes

NASA Astrophysics Data System (ADS)

Antonio, F. G.; Kottmann, R.; Wallom, D.; Glöckner, F. O.

2016-02-01

The Ocean Sampling Day (OSD) is a simultaneous, collaborative, standardized, and global mega-sequencing campaign to analyze marine microbial community composition and functional traits. 150 metagenomes were sequenced from the first OSD in June 2014 including a rich set of environmental and oceanographic measurements. Unlike other ocean mega-surveys such as Global Ocean Sampling (GOS) or the TARA expedition that mostly sampled open ocean waters most of the OSD samples are from coastal sampling sites, an area not previously well studied in this regard. The result is that OSD adds more than three million new genes to the recently published Ocean Microbial-Reference Gene Catalog (Sunawaga et al., 2015). This allows us to significantly increase our knowledge of the ocean microbiome, identify hot-spots of novelty in terms of function and investigate the impact of human activities on oceans coastal areas where there is the largest interaction between dense human populations and the marine world. Additionally, these cumulative samples, related in time, space and environmental parameters, are providing insights into fundamental rules describing microbial diversity and function and contribute to the blue economy through the identification of novel ocean-derived biotechnologies. References: Sunagawa, Coelho, Chaffron, et al. (2015, May). Structure and function of the global ocean microbiome. Science, 348(6237), 126135.

North Atlantic Ocean OSSE system development: Nature Run evaluation and application to hurricane interaction with the Gulf Stream

NASA Astrophysics Data System (ADS)

Kourafalou, Vassiliki H.; Androulidakis, Yannis S.; Halliwell, George R.; Kang, HeeSook; Mehari, Michael M.; Le Hénaff, Matthieu; Atlas, Robert; Lumpkin, Rick

2016-11-01

A high resolution, free-running model has been developed for the hurricane region of the North Atlantic Ocean. The model is evaluated with a variety of observations to ensure that it adequately represents both the ocean climatology and variability over this region, with a focus on processes relevant to hurricane-ocean interactions. As such, it can be used as the "Nature Run" (NR) model within the framework of Observing System Simulation Experiments (OSSEs), designed specifically to improve the ocean component of coupled ocean-atmosphere hurricane forecast models. The OSSE methodology provides quantitative assessment of the impact of specific observations on the skill of forecast models and enables the comprehensive design of future observational platforms and the optimization of existing ones. Ocean OSSEs require a state-of-the-art, high-resolution free-running model simulation that represents the true ocean (the NR). This study concentrates on the development and data based evaluation of the NR model component, which leads to a reliable model simulation that has a dual purpose: (a) to provide the basis for future hurricane related OSSEs; (b) to explore process oriented studies of hurricane-ocean interactions. A specific example is presented, where the impact of Hurricane Bill (2009) on the eastward extension and transport of the Gulf Stream is analyzed. The hurricane induced cold wake is shown in both NR simulation and observations. Interaction of storm-forced currents with the Gulf Stream produced a temporary large reduction in eastward transport downstream from Cape Hatteras and had a marked influence on frontal displacement in the upper ocean. The kinetic energy due to ageostrophic currents showed a significant increase as the storm passed, and then decreased to pre-storm levels within 8 days after the hurricane advanced further north. This is a unique result of direct hurricane impact on a western boundary current, with possible implications on the ocean feedback on hurricane evolution.

Quantitative Analysis of the Distribution of cis-Eicosenoic Acid Positional Isomers in Marine Fishes from the Indian Ocean.

PubMed

Senarath, Samanthika; Yoshinaga, Kazuaki; Nagai, Toshiharu; Yoshida, Akihiko; Beppu, Fumiaki; Jayasinghe, Chamila; Devadawson, Chandravathany; Gotoh, Naohiro

2017-02-01

This study investigated the occurrence and distribution of cis-eicosenoic acid (c-20:1) positional isomers in fishes from the Indian Ocean and compared to those from the Pacific and Atlantic Ocean. Lipids were extracted from the edible part of the fish and then methylated. The eicosenoic acid methyl ester fraction was separated from total fatty acid methyl esters by reversed-phase HPLC and quantitatively analyzed using a GC-FID fitted with the SLB-IL111 highly polar GC column. c14-20:1 was used as an internal standard. The results indicated that the highest levels of c-20:1 positional isomers were found in fishes from the Pacific Ocean (saury, 166.95±12.4 mg/g of oil), followed by the Atlantic Ocean (capelin, 162.7±3.5 mg/g of oil), and lastly in fishes from the Indian Ocean (goatfish, 34.39 mg/g of oil). With only a few exceptions, the most abundant 20:1 positional isomer found in fishes of the Indian and Atlantic Ocean was the c11-20:1 isomer (>50%) followed by the c13-20:1 isomer (<25%). Unusually, the c7-20:1 isomer was predominantly found in a few fishes such as the tooth ponyfish, longface emperor, and commerson's sole. The c9, c5, and c15-20:1 isomers were the least occurring in fishes from the Indian and Atlantic Ocean. In contrast, the c9-20:1 isomer was the principal isomer identified in fishes from the Pacific Ocean. The results revealed that the content and distribution of c-20:1 positional isomers varied among fishes in different oceans. The data presented in the current study are the first to report on the distribution of c-20:1 positional isomers in fishes from the Indian Ocean.

Climate, carbon cycling, and deep-ocean ecosystems.

PubMed

Smith, K L; Ruhl, H A; Bett, B J; Billett, D S M; Lampitt, R S; Kaufmann, R S

2009-11-17

Climate variation affects surface ocean processes and the production of organic carbon, which ultimately comprises the primary food supply to the deep-sea ecosystems that occupy approximately 60% of the Earth's surface. Warming trends in atmospheric and upper ocean temperatures, attributed to anthropogenic influence, have occurred over the past four decades. Changes in upper ocean temperature influence stratification and can affect the availability of nutrients for phytoplankton production. Global warming has been predicted to intensify stratification and reduce vertical mixing. Research also suggests that such reduced mixing will enhance variability in primary production and carbon export flux to the deep sea. The dependence of deep-sea communities on surface water production has raised important questions about how climate change will affect carbon cycling and deep-ocean ecosystem function. Recently, unprecedented time-series studies conducted over the past two decades in the North Pacific and the North Atlantic at >4,000-m depth have revealed unexpectedly large changes in deep-ocean ecosystems significantly correlated to climate-driven changes in the surface ocean that can impact the global carbon cycle. Climate-driven variation affects oceanic communities from surface waters to the much-overlooked deep sea and will have impacts on the global carbon cycle. Data from these two widely separated areas of the deep ocean provide compelling evidence that changes in climate can readily influence deep-sea processes. However, the limited geographic coverage of these existing time-series studies stresses the importance of developing a more global effort to monitor deep-sea ecosystems under modern conditions of rapidly changing climate.

Ocean acidification research in the 'post-genomic' era: Roadmaps from the purple sea urchin Strongylocentrotus purpuratus.

PubMed

Evans, Tyler G; Padilla-Gamiño, Jacqueline L; Kelly, Morgan W; Pespeni, Melissa H; Chan, Francis; Menge, Bruce A; Gaylord, Brian; Hill, Tessa M; Russell, Ann D; Palumbi, Stephen R; Sanford, Eric; Hofmann, Gretchen E

2015-07-01

Advances in nucleic acid sequencing technology are removing obstacles that historically prevented use of genomics within ocean change biology. As one of the first marine calcifiers to have its genome sequenced, purple sea urchins (Strongylocentrotus purpuratus) have been the subject of early research exploring genomic responses to ocean acidification, work that points to future experiments and illustrates the value of expanding genomic resources to other marine organisms in this new 'post-genomic' era. This review presents case studies of S. purpuratus demonstrating the ability of genomic experiments to address major knowledge gaps within ocean acidification. Ocean acidification research has focused largely on species vulnerability, and studies exploring mechanistic bases of tolerance toward low pH seawater are comparatively few. Transcriptomic responses to high pCO₂ seawater in a population of urchins already encountering low pH conditions have cast light on traits required for success in future oceans. Secondly, there is relatively little information on whether marine organisms possess the capacity to adapt to oceans progressively decreasing in pH. Genomics offers powerful methods to investigate evolutionary responses to ocean acidification and recent work in S. purpuratus has identified genes under selection in acidified seawater. Finally, relatively few ocean acidification experiments investigate how shifts in seawater pH combine with other environmental factors to influence organism performance. In S. purpuratus, transcriptomics has provided insight into physiological responses of urchins exposed simultaneously to warmer and more acidic seawater. Collectively, these data support that similar breakthroughs will occur as genomic resources are developed for other marine species. Copyright © 2015 Elsevier Inc. All rights reserved.

Fiber-coupling efficiency of Gaussian-Schell model beams through an ocean to fiber optical communication link

NASA Astrophysics Data System (ADS)

Hu, Beibei; Shi, Haifeng; Zhang, Yixin

2018-06-01

We theoretically study the fiber-coupling efficiency of Gaussian-Schell model beams propagating through oceanic turbulence. The expression of the fiber-coupling efficiency is derived based on the spatial power spectrum of oceanic turbulence and the cross-spectral density function. Our work shows that the salinity fluctuation has a greater impact on the fiber-coupling efficiency than temperature fluctuation does. We can select longer λ in the "ocean window" and higher spatial coherence of light source to improve the fiber-coupling efficiency of the communication link. We also can achieve the maximum fiber-coupling efficiency by choosing design parameter according specific oceanic turbulence condition. Our results are able to help the design of optical communication link for oceanic turbulence to fiber sensor.

Genetic algorithm for investigating flight MH370 in Indian Ocean using remotely sensed data

NASA Astrophysics Data System (ADS)

Marghany, Maged; Mansor, Shattri; Shariff, Abdul Rashid Bin Mohamed

2016-06-01

This study utilized Genetic algorithm (GA) for automatic detection and simulation trajectory movements of flight MH370 debris. In doing so, the Ocean Surface Topography Mission(OSTM) on the Jason- 2 satellite have been used within 1 and half year covers data to simulate the pattern of Flight MH370 debris movements across the southern Indian Ocean. Further, multi-objectives evolutionary algorithm also used to discriminate uncertainty of flight MH370 imagined and detection. The study shows that the ocean surface current speed is 0.5 m/s. This current patterns have developed a large anticlockwise gyre over a water depth of 8,000 m. The multi-objectives evolutionary algorithm suggested that objects are existed on satellite data are not flight MH370 debris. In addition, multiobjectives evolutionary algorithm suggested that the difficulties to acquire the exact location of flight MH370 due to complicated hydrodynamic movements across the southern Indian Ocean.

Trace elements in oceanic pelagic communities in the western Indian Ocean.

PubMed

Bodin, Nathalie; Lesperance, Dora; Albert, Rona; Hollanda, Stephanie; Michaud, Philippe; Degroote, Maxime; Churlaud, Carine; Bustamante, Paco

2017-05-01

The mineral composition of target and non-target pelagic fish caught by purse-seiners and longliners in the western-central Indian Ocean was determined. From the 10 essential elements analysed, selenium and zinc showed the highest concentrations in swordfish and blue marlin while Indian mackerel appeared as a good source of copper, iron and chrome. All catch had levels of lead and cadmium, two toxic elements, below the maximum sanitary limits. Although some concerns were raised regarding mercury concentrations in the largest species (wahoo, swordfish and blue marlin), molar ratios of mercury and selenium indicate that all oceanic pelagic fish from the western-central Indian Ocean are safe for human consumption. This study also gives insights on the relationships between the levels of essential and toxic elements in fish muscle and the size, trophic position and diet sources of the studied pelagic species. Copyright © 2017 Elsevier Ltd. All rights reserved.

Ocean N2O Emissions : Recent Global Estimates and Anthropogenically Influenced Changes

NASA Astrophysics Data System (ADS)

Suntharalingam, P.; Buithenuis, E.; Andrews, O.; Le Quere, C.

2016-12-01

Oceanic N2O is produced by microbial activity during organic matter cycling in the subsurface ocean; its production mechanisms display sensitivity to ambient oxygen level. In the oxic ocean, N2O is produced as a byproduct during the oxidation of ammonia to nitrate, mediated by ammonia oxidizing bacteria and archea. N2O is also produced and consumed in sub-oxic and anoxic waters through the action of marine denitrifiers during the multi-step reduction of nitrate to gaseous nitrogen. The oceanic N2O distribution therefore displays significant heterogeneity with background levels of 10-20 nmol/l in the well-oxygenated ocean basins, high concentrations (> 40 nmol/l) in hypoxic waters, and N2O depletion in the core of ocean oxygen minimum zones (OMZs). Oceanic N2O emissions are estimated to account for up to a third of the pre-industrial N2O fluxes to the atmosphere, however the natural cycle of ocean N2O has been perturbed in recent decades by inputs of anthropogenically derived nutrient, and by the impacts of climate change. Anthropogenic nitrogen inputs (e.g., NOx and NHy from fossil fuel combustion and agricultural fertilizer) enter the ocean via atmospheric deposition and riverine fluxes, influencing oceanic N2O production via their impact on the marine organic matter cycle. In addition, climate variations associated with surface ocean warming affect oceanic circulation and nutrient transport pathways, influencing marine productivity and the ventilation of oxygen minimum zones. Recent studies have suggested that possible expansion of oceanic OMZs in a warming climate could lead to significant changes in N2O production and fluxes from these regions. We will summarise the current state of knowledge on the ocean N2O budget and net flux to the atmosphere. Recently reported estimates have been based on (i) empirical relationships derived from ocean tracer data (e.g., involving excess N2O and Apparent Oxygen Utilization (AOU) correlations), (ii) ocean biogeochemical models, and (iii) air-sea flux calculations which combine surface ocean N2O measurements with gas-exchange relationships. We will also present results from ongoing ocean biogeochemistry model analyses evaluating the separate influences of climate variation and anthropogenic nutrient inputs on ocean N2O emissions for recent decades.

Focus: knowing the ocean: a role for the history of science.

PubMed

Rozwadowski, Helen M

2014-06-01

While most historians have treated the sea as a surface or a void, the history of science is well positioned to draw the ocean itself into history. The contributors to this Focus section build on the modest existing tradition of history of oceanography and extend that tradition to demonstrate both the insights to be gained by studying oceans historically and the critical role that the history of science should play in future environmental history of the ocean.

Mid-Bay Islands Hydrodynamics and Sedimentation Modeling Study, Chesapeake Bay

DTIC Science & Technology

2006-08-01

largest estuary in the United States, extending more than 150 miles from its seaward end at the Atlantic Ocean to the bayward end at the entrance to...water enters the bay from more than 150 major rivers and streams at approximately 80,000 cu ft/sec. Ocean tides enter the bay through the Atlantic ...Ocean entrance and C&D Canal. The mean range of tides in the bay varies from approximately 1 ft on the western shore to 3 ft at the Atlantic Ocean

Tidal Response of Europa's Subsurface Ocean

NASA Astrophysics Data System (ADS)

Karatekin, O.; Comblen, R.; Deleersnijder, E.; Dehant, V. M.

2010-12-01

Time-variable tides in the subsurface oceans of icy satellites cause large periodic surface displacements and tidal dissipation can become a major energy source that can affect long-term orbital and internal evolution. In the present study, we investigate the response of the subsurface ocean of Europa to a time-varibale tidal potential. Two-dimensional nonlinear shallow water equations are solved on a sphere by means of a finite element code. The resulting ocean tidal flow velocities,dissipation and surface displacements will be presented.

Decoupling of Iron and Phosphate in the Global Ocean

NASA Technical Reports Server (NTRS)

Parekh, Payal

2003-01-01

Iron is an essential micronutrient for marine phytoplankton, limiting their growth in high nutrient, low chlorophyll regions of the ocean. I use a hierarchy of ocean circulation and biogeochemistry models to understand controls on global iron distribution. I formulate a mechanistic model of iron cycling which includes scavenging onto sinking particles and complexation with an organic ligand. The iron cycle is coupled to a phosphorus cycling model. Iron's aeolian source is prescribed. In the context of a highly idealized multi-box model scheme, the model can be brought into consistency with the relatively sparse ocean observations of iron in the oceans. This biogeochemical scheme is also implemented in a coarse resolution ocean general circulation model. This model also successfully reproduces the broad regional patterns of iron and phosphorus. In particular, the high macronutrient concentrations of the Southern Ocean result from iron limitation in the model. Due to the potential ability of iron to change the efficiency of the carbon pump in the remote Southern Ocean, I study Southern Ocean surface phosphate response to increased aeolian dust flux. My box model and GCM results suggest that a global ten fold increase in dust flux can support a phosphate drawdown of 0.25-0.5 micromolar.

Inside the Black Box

ERIC Educational Resources Information Center

Kao, Yvonne S.; Cina, Anthony; Gimm, J. Aura

2006-01-01

Scientists often have to observe and study surfaces that are impossible or impractical to see directly, such as the ocean floor or the atomic surfaces of objects. Early in the history of oceanography scientists dropped weighted cables to the bottom of the ocean. By moving across the ocean at regular intervals and keeping track of how deep the…

Skills Conversion Project: Chapter 10, Ocean Engineering and Oceanography. Final Report.

ERIC Educational Resources Information Center

National Society of Professional Engineers, Washington, DC.

In order to determine the potential utilization of displaced aerospace and defense technical professionals in oceanography and ocean engineering, a study of ocean-oriented industry in Florida and Southern California was conducted by The National Society of Professional Engineers for the U.S. Department of Labor. After recent consolidation, this…

Calcification in Caribbean reef-building corals at high pCO2 levels in a recirculating ocean acidification exposure system

EPA Science Inventory

Projected increases in ocean pCO2 levels are anticipated to affect calcifying organisms more rapidly and to a greater extent than other marine organisms. The effects of ocean acidification (OA) have been documented in numerous species of corals in laboratory studies, largely test...

Remote sensing of rain over the ocean

NASA Technical Reports Server (NTRS)

1978-01-01

Computer models of the microwave emission from the earth's atmosphere were used to study the problem of retrieving meteorological information from the SMMR instrument that will be flown on NIMBUS-G. Methods for retrieving rain rate, wind speed, cloud height, and ocean temperature are described for the case when the satellite is over the ocean.

Coastal Residents Ocean Literacy about Seawater Desalination and its Impacts on Marine Ecosystems in the Monterey Bay

NASA Astrophysics Data System (ADS)

Faraola, S.; Heck, N.; Mirza Ordshahi, B.; Paytan, A.; Petersen, K. L.; Haddad, B.; Potts, D. C.

2016-12-01

The current lack of available freshwater in California has brought about the consideration of utilizing seawater desalination to provide a consistent drinking water source for local residents of coastal areas. Public literacy about this technology and its impacts on the ocean is vital to making informed policy decisions about marine resources and ecosystems, which may empower local communities to become more involved stewards of the ocean. Our study evaluates public literacy about seawater desalination and its impacts on the ocean. Data was collected using a questionnaire-based survey from a randomly selected sample of residents and marine stakeholders in coastal communities around Monterey Bay. The study explored (1) self-assessed and accurate knowledge about marine impacts from seawater desalination and (2) what shapes public literacy concerning pertinent ocean issues in communities near a National Marine Sanctuary. Our findings show to what extent the public is prepared to engage in meaningful discussions about marine issues and seawater desalination and if an understanding of the ocean shapes perceptions on saltwater desalination.

Simultaneous generation and scattering of internal tides by ocean floor topography

NASA Astrophysics Data System (ADS)

Mathur, Manikandan

2015-11-01

Internal waves play a significant role in the global energy budget of the ocean, with internal tides potentially contributing to the conversion of a large amount of mechanical energy into heat in the deep ocean. Several studies in the past decade have investigated internal tide generation and internal tide scattering by ocean floor topography, but by treating them as two separate, independent processes. In this talk, we use the recently developed Green function model (Mathur et al., J. Geophys. Res. Oceans, 119, 2165-2182, 2014), sans the WKB approximation, to quantify the extent to which internal tide generation (scattering) that results from barotropic (baroclinic) forcing on small- and large-scale topography in uniform and nonuniform stratifications is modified by the presence of a background baroclinic (barotropic) tide. Results on idealized topography, stratification and forcing will first be presented, followed by a discussion on the relevance of our studies in the real ocean scenario. The author thanks the Ministry of Earth Sciences, Government of India for financial support under the Monsoon Mission Grant MM/2014/IND-002.

Investigating the Relationship between Ocean Surface Currents and Seasonal Precipitation in the Western United States

NASA Astrophysics Data System (ADS)

Chiang, F.; AghaKouchak, A.

2017-12-01

While many studies have explored the predictive capabilities of teleconnections associated with North American climate, currently established teleconnections offer limited predictability for rainfall in the Western United States. A recent example was the 2015-16 California drought in which a strong ENSO signal did not lead to above average precipitation as was expected. From an exploration of climate and ocean variables available from satellite data, we hypothesize that ocean currents can provide additional information to explain precipitation variability and improve seasonal predictability on the West Coast. Since ocean currents are influenced by surface wind and temperatures, characterizing connections between currents and precipitation patterns has the potential to further our understanding of coastal weather patterns. For the study, we generated gridded point correlation maps to identify ocean areas with high correlation to precipitation time series corresponding to climate regions in the West Coast region. We also used other statistical measures to evaluate ocean `hot spot' regions with significant correlation to West Coast precipitation. Preliminary results show that strong correlations can be found in the tropical regions of the globe.

Salinity Processes in the Upper Ocean Regional Study (SPURS)

NASA Image and Video Library

2012-09-04

University of Washington Graduate Student Jesse Anderson tries to find her cabin onboard the Woods Hole Oceanographic Institution research vessel Knorr on Tuesday, Sept. 4, 2012, in Woods Hole, Mass. Anderson will work with the Argo Floats instruments in the Atlantic Ocean as part of the Salinity Processes in the Upper Ocean Regional Study (SPURS) which is set to sail on Sept. 6. The NASA-sponsored expedition will sail to the North Atlantic's saltiest spot to get a detailed, 3-D picture of how salt content fluctuates in the ocean's upper layers and how these variations are related to shifts in rainfall patterns around the planet. Photo Credit: (NASA/Bill Ingalls)

Salinity Processes in the Upper Ocean Regional Study (SPURS)

NASA Image and Video Library

2012-09-04

Woods Hole Oceanographic Institution Senior Engineer Steve Faluotico works on the SPURS buoy prior to it being loaded onto the Institute's research vessel Knorr, Tuesday, Sept. 4, 2012, in Woods Hole, Mass. The SPURS buoy will be deployed in the Atlantic Ocean as part of the Salinity Processes in the Upper Ocean Regional Study (SPURS) which is set to sail on Sept. 6. The NASA-sponsored expedition will sail to the North Atlantic's saltiest spot to get a detailed, 3-D picture of how salt content fluctuates in the ocean's upper layers and how these variations are related to shifts in rainfall patterns around the planet. Photo Credit: (NASA/Bill Ingalls)

Salinity Processes in the Upper Ocean Regional Study (SPURS)

NASA Image and Video Library

2012-09-05

An worker prepares to attached a crane hook onto a sensor-laden buoy so that it may be loaded onboard the Woods Hole Oceanographic Institution's research vessel Knorr on wednesday, Sept. 5, 2012, in Woods Hole, Mass. The buoy will be deployed in the Atlantic Ocean as part of the Salinity Processes in the Upper Ocean Regional Study (SPURS) which is set to sail on Sept. 6. The NASA-sponsored expedition will sail to the North Atlantic's saltiest spot to get a detailed, 3-D picture of how salt content fluctuates in the ocean's upper layers and how these variations are related to shifts in rainfall patterns around the planet. Photo Credit: (NASA/Bill Ingalls)

Salinity Processes in the Upper Ocean Regional Study (SPURS)

NASA Image and Video Library

2012-09-04

Sean Whelan, a Marine Technician for the Woods Hole Oceanographic Institution, prepares CTD instruments used to measure Conductivity, Temperature, and Depth, onboard the Institute's research vessel Knorr on Tuesday, Sept. 4, 2012, in Woods Hole, Mass. The CTDs will be deployed in the Atlantic Ocean as part of the Salinity Processes in the Upper Ocean Regional Study (SPURS) which is set to sail on Sept. 6. The NASA-sponsored expedition will sail to the North Atlantic's saltiest spot to get a detailed, 3-D picture of how salt content fluctuates in the ocean's upper layers and how these variations are related to shifts in rainfall patterns around the planet. Photo Credit: (NASA/Bill Ingalls)

Salinity Processes in the Upper Ocean Regional Study (SPURS)

NASA Image and Video Library

2012-09-04

NASA Physical Oceanography Program Scientist Eric Lindstrom inspects a sensor-laden buoy prior to it being loaded onboard the Woods Hole Oceanographic Institution's vessel Knorr on Tuesday, Sept. 4, 2012, in Woods Hole, Mass. The buoy will be deployed in the Atlantic Ocean as part of the Salinity Processes in the Upper Ocean Regional Study (SPURS) which is set to sail on Sept. 6. The NASA-sponsored expedition will sail to the North Atlantic's saltiest spot to get a detailed, 3-D picture of how salt content fluctuates in the ocean's upper layers and how these variations are related to shifts in rainfall patterns around the planet. Photo Credit: (NASA/Bill Ingalls)

USSR and Eastern Europe Scientific Abstracts, Geophysics, Astronomy and Space, Number 403

DTIC Science & Technology

1977-08-17

34Akademik Kurchatov" Departs for " Polimode " Ocean Experiment.... 11 Scientists Perform Oceanic Studies Near Wrangel Island 11 Abstracts of...stratosphere. [198] 10 III. OCEANOGRAPHY News "AKADEMIK KURCHATOV" DEPARTS FOR " POLIMODE " OCEAN EXPERIMENT Moscow PRAVDA in Russian 30 Jun 77 p 6 [Article...studies under the POLIMODE program. The head of the expedition, Professor V. Kort, commented on the pur- poses and tasks of the experiment: "Several

Worldwide Emerging Environmental Issues Affecting the U.S. Military. February 2010

DTIC Science & Technology

2010-02-01

claims study http://www.independent.co.uk/environment/nature/ oceans -acidity-rate-is-soaring-claims-study-1899536.html World’s coral reefs could...GDP is linked to coastal natural resources. Already, 40% of coral reefs and 50% of mangrove swamps have been lost. Coral reefs generate an estimated...Geoscience, the current rate of ocean acidification is up to 10 times faster than 55 million years ago—the last time deep oceans were so acidic. The

Ocean-ice interaction in the marginal ice zone

NASA Technical Reports Server (NTRS)

Liu, Antony K.; Peng, Chich Y.

1994-01-01

Ocean ice interaction processes in the Marginal Ice Zone (MIZ) by wind, waves, and mesoscale features, such as upwelling and eddies, are studied using ERS-1 Synthetic Aperture Radar (SAR) images and ocean ice interaction model. A sequence of SAR images of the Chukchi Sea MIZ with three days interval are studied for ice edge advance/retreat. Simultaneous current measurements from the northeast Chukchi Sea as well as the Barrow wind record are used to interpret the MIZ dynamics.

Some General Laws of Chemical Elements Composition Dynamics in the Hydrosphere

NASA Astrophysics Data System (ADS)

Korzh, V.

2012-12-01

The biophysical oceanic composition is a result of substance migration and transformation on river-sea and ocean- atmosphere boundaries. Chemical composition of oceanic water is a fundamental multi-dimensional constant for our planet. Detailed studies revealed three types of chemical element distribution in the ocean: 1) Conservative: concentration normalized to salinity is constant in space and time; 2) Nutrient-type: element concentration in the surface waters decreases due to the biosphere consumption; and 3) Litho-generative: complex character of distribution of elements, which enter the ocean with the river runoff and interred almost entirely in sediments (Fig. 1). The correlation between the chemical compositions of the river and oceanic water is high (r = 0.94). We conclude that biogeochemical features of each element are determined by the relationship between its average concentration in the ocean and the intensity of its migration through hydrosphere boundary zones. In Fig.1 we show intensities of global migration and average concentrations in the ocean in the coordinates lgC - lg τ, where C is an average element concentration and τ is its residual time in the ocean. Fig. 1 shows a relationship between three main geochemical parameters of the dissolved forms of chemical elements in the hydrosphere: 1) average concentration in the ocean, 2) average concentration in the river runoff and 3) the type of distribution in oceanic water. Using knowledge of two of these parameters, it allows gaining theoretical knowledge of the third. The System covers all chemical elements for the entire range of observed concentrations. It even allows to predict the values of the annual river transport of dissolved Be, C, N, Ge, Tl, Re, to refine such estimates for P, V, Zn, Br, I, and to determine the character of distribution in the ocean for Au and U. Furthermore, the System allowed to estimate natural (unaffected by anthropogenic influence) mean concentrations of elements in the river runoff and use them as ecological reference data. Finally, due to the long response time of the ocean, the mean concentrations of elements and patterns of their distribution in the ocean can be used to determine pre-technogenic concentrations of elements in the river runoff. An example of such studies for the Northern Eurasia Arctic Rivers will be presented at the conference. References Korzh 1974: J. de Recher. Atmos, 8, 653-660. Korzh 2008: J. Ecol., 15, 13-21. Korzh 2012: Water: Chem. & Ecol., No. 1, 56-62; Fig.1. The System of chemical elements distribution in the hydrosphere. Types of distribution in the ocean: 1) conservative; 2) nutrient-type; 3) litho-generative.

Application synergies between the NASA Pre- Aerosol Cloud and ocean Ecosystem (PACE) and Hyperspectral Infrared Imager (HyspIRI) missions

NASA Astrophysics Data System (ADS)

Lee, C. M.; Omar, A. H.; Hook, S. J.; Tzortziou, M.; Luvall, J. C.; Turner, W. W.

2016-02-01

Observations from the Pre-Aerosol Cloud and ocean Ecosystem (PACE) and Hyperspectral InfraRed Imager (HyspIRI) satellite missions are highly complementary and have the potential to significantly advance understanding of various science and applications challenges in the ocean sciences and water quality communities. Scheduled for launch in the 2022 timeframe, PACE is designed to make climate-quality global measurements essential for understanding ocean biology, biogeochemistry and ecology, and determining the role of the ocean in global biogeochemical cycling and ocean ecology, and how it affects and is affected by climate change. PACE will provide high signal-to-noise, hyperspectral observations over an extended spectral range (UV to SWIR) and will have global coverage every 1-2 days, at approximately 1 km spatial resolution; furthermore, PACE is currently designed to include a polarimeter, which will vastly improve atmospheric correction algorithms over water bodies. The PACE mission will enable advances in applications across a range of areas, including oceans, climate, water resources, ecological forecasting, disasters, human health and air quality. HyspIRI, with contiguous measurements in VSWIR, and multispectral measurements in TIR, will be able to provide detailed spectral observations and higher spatial resolution (30 to 60-m) over aquatic systems, but at a temporal resolution that is approximately 5-16 days. HyspIRI would enable improved, detailed studies of aquatic ecosystems, including benthic communities, algal blooms, coral reefs, and wetland species distribution as well as studies of water quality indicators or pollutants such as oil spills, suspended sediment, and colored dissolved organic matter. Together, PACE and HyspIRI will be able to address numerous applications and science priorities, including improving and extending climate data records, and studies of inland, coastal and ocean environments.

Constraints on Southern Ocean CO2 Fluxes and Seasonality from Atmospheric Vertical Gradients Observed on Multiple Airborne Campaigns

NASA Astrophysics Data System (ADS)

McKain, K.; Sweeney, C.; Stephens, B. B.; Long, M. C.; Jacobson, A. R.; Basu, S.; Chatterjee, A.; Weir, B.; Wofsy, S. C.; Atlas, E. L.; Blake, D. R.; Montzka, S. A.; Stern, R.

2017-12-01

The Southern Ocean plays an important role in the global carbon cycle and climate system, but net CO2 flux into the Southern Ocean is difficult to measure and model because it results from large opposing and seasonally-varying fluxes due to thermal forcing, biological uptake, and deep-water mixing. We present an analysis to constrain the seasonal cycle of net CO2 exchange with the Southern Ocean, and the magnitude of summer uptake, using the vertical gradients in atmospheric CO2 observed during three aircraft campaigns in the southern polar region. The O2/N2 Ratio and CO2 Airborne Southern Ocean Study (ORCAS) was an airborne campaign that intensively sampled the atmosphere at 0-13 km altitude and 45-75 degrees south latitude in the austral summer (January-February) of 2016. The global airborne campaigns, the HIAPER Pole-to-Pole Observations (HIPPO) study and the Atmospheric Tomography Mission (ATom), provide additional measurements over the Southern Ocean from other seasons and multiple years (2009-2011, 2016-2017). Derivation of fluxes from measured vertical gradients requires robust estimates of the residence time of air in the polar tropospheric domain, and of the contribution of long-range transport from northern latitudes outside the domain to the CO2 gradient. We use diverse independent approaches to estimate both terms, including simulations using multiple transport and flux models, and observed gradients of shorter-lived tracers with specific sources regions and well-known loss processes. This study demonstrates the utility of aircraft profile measurements for constraining large-scale air-sea fluxes for the Southern Ocean, in contrast to those derived from the extrapolation of sparse ocean and atmospheric measurements and uncertain flux parameterizations.

The Southern Ocean biogeochemical divide.

PubMed

Marinov, I; Gnanadesikan, A; Toggweiler, J R; Sarmiento, J L

2006-06-22

Modelling studies have demonstrated that the nutrient and carbon cycles in the Southern Ocean play a central role in setting the air-sea balance of CO(2) and global biological production. Box model studies first pointed out that an increase in nutrient utilization in the high latitudes results in a strong decrease in the atmospheric carbon dioxide partial pressure (pCO2). This early research led to two important ideas: high latitude regions are more important in determining atmospheric pCO2 than low latitudes, despite their much smaller area, and nutrient utilization and atmospheric pCO2 are tightly linked. Subsequent general circulation model simulations show that the Southern Ocean is the most important high latitude region in controlling pre-industrial atmospheric CO(2) because it serves as a lid to a larger volume of the deep ocean. Other studies point out the crucial role of the Southern Ocean in the uptake and storage of anthropogenic carbon dioxide and in controlling global biological production. Here we probe the system to determine whether certain regions of the Southern Ocean are more critical than others for air-sea CO(2) balance and the biological export production, by increasing surface nutrient drawdown in an ocean general circulation model. We demonstrate that atmospheric CO(2) and global biological export production are controlled by different regions of the Southern Ocean. The air-sea balance of carbon dioxide is controlled mainly by the biological pump and circulation in the Antarctic deep-water formation region, whereas global export production is controlled mainly by the biological pump and circulation in the Subantarctic intermediate and mode water formation region. The existence of this biogeochemical divide separating the Antarctic from the Subantarctic suggests that it may be possible for climate change or human intervention to modify one of these without greatly altering the other.

An update to the Surface Ocean CO2 Atlas (SOCAT version 2)

NASA Astrophysics Data System (ADS)

Bakker, D. C. E.; Pfeil, B.; Smith, K.; Hankin, S.; Olsen, A.; Alin, S. R.; Cosca, C.; Harasawa, S.; Kozyr, A.; Nojiri, Y.; O'Brien, K. M.; Schuster, U.; Telszewski, M.; Tilbrook, B.; Wada, C.; Akl, J.; Barbero, L.; Bates, N.; Boutin, J.; Cai, W.-J.; Castle, R. D.; Chavez, F. P.; Chen, L.; Chierici, M.; Currie, K.; de Baar, H. J. W.; Evans, W.; Feely, R. A.; Fransson, A.; Gao, Z.; Hales, B.; Hardman-Mountford, N.; Hoppema, M.; Huang, W.-J.; Hunt, C. W.; Huss, B.; Ichikawa, T.; Johannessen, T.; Jones, E. M.; Jones, S. D.; Jutterström, S.; Kitidis, V.; Körtzinger, A.; Landschtzer, P.; Lauvset, S. K.; Lefèvre, N.; Manke, A. B.; Mathis, J. T.; Merlivat, L.; Metzl, N.; Murata, A.; Newberger, T.; Ono, T.; Park, G.-H.; Paterson, K.; Pierrot, D.; Ríos, A. F.; Sabine, C. L.; Saito, S.; Salisbury, J.; Sarma, V. V. S. S.; Schlitzer, R.; Sieger, R.; Skjelvan, I.; Steinhoff, T.; Sullivan, K.; Sun, H.; Sutton, A. J.; Suzuki, T.; Sweeney, C.; Takahashi, T.; Tjiputra, J.; Tsurushima, N.; van Heuven, S. M. A. C.; Vandemark, D.; Vlahos, P.; Wallace, D. W. R.; Wanninkhof, R.; Watson, A. J.

2013-08-01

The Surface Ocean CO2 Atlas (SOCAT) is an effort by the international marine carbon research community. It aims to improve access to carbon dioxide measurements in the surface oceans by regular releases of quality controlled and fully documented synthesis and gridded fCO2 (fugacity of carbon dioxide) products. SOCAT version 2 presented here extends the data set for the global oceans and coastal seas by four years and has 10.1 million surface water fCO2 values from 2660 cruises between 1968 and 2011. The procedures for creating version 2 have been comparable to those for version 1. The SOCAT website (http://www.socat.info/) provides access to the individual cruise data files, as well as to the synthesis and gridded data products. Interactive online tools allow visitors to explore the richness of the data. Scientific users can also retrieve the data as downloadable files or via Ocean Data View. Version 2 enables carbon specialists to expand their studies until 2011. Applications of SOCAT include process studies, quantification of the ocean carbon sink and its spatial, seasonal, year-to-year and longer-term variation, as well as initialisation or validation of ocean carbon models and coupled-climate carbon models.

Characteristics of the oceanic MCC, continental MCC, and coastal MCC over the Indonesian maritime continent

NASA Astrophysics Data System (ADS)

Trismidianto

2018-05-01

This study explains the comparison of mesoscale convective complexes (MCC) characteristics in the oceans, land and in the coast over Indonesian maritime continent (IMC). MCCs were identified and tracked during 15-years (2001-2015) over IMC by infrared satellite imagery using an algorithm that combines criteria of cloud coverage, eccentricity, and cloud lifetime. Infrared satellite imagery was obtained from Himawari generation satellite data. This study showed most of the continental MCC found near the mountains and the high elevation areas. The frequency of MCC occurrences was larger over the land than over the ocean. The oceanic MCCs, which lasted for more than 12 hours, were longer-lived than the continental MCCs. The MCCs with small size most frequently occurred in the continent, in contrast, the MCC with the medium and large size were most concentrated over the ocean. Generally, the continental and coastal MCC initiation occurs in the late afternoon and reach maximum size around midnight before decaying the next morning. In contrast, the oceanic MCC dominantly develops in midnight, and reach maximum size in the morning and then MCC decayed and dissipated from noon until afternoon. The evolution of MCC development in the ocean, land, and in the coast has almost the same stages and ways.

Coral Carbonic Anhydrases: Regulation by Ocean Acidification.

PubMed

Zoccola, Didier; Innocenti, Alessio; Bertucci, Anthony; Tambutté, Eric; Supuran, Claudiu T; Tambutté, Sylvie

2016-06-03

Global change is a major threat to the oceans, as it implies temperature increase and acidification. Ocean acidification (OA) involving decreasing pH and changes in seawater carbonate chemistry challenges the capacity of corals to form their skeletons. Despite the large number of studies that have investigated how rates of calcification respond to ocean acidification scenarios, comparatively few studies tackle how ocean acidification impacts the physiological mechanisms that drive calcification itself. The aim of our paper was to determine how the carbonic anhydrases, which play a major role in calcification, are potentially regulated by ocean acidification. For this we measured the effect of pH on enzyme activity of two carbonic anhydrase isoforms that have been previously characterized in the scleractinian coral Stylophora pistillata. In addition we looked at gene expression of these enzymes in vivo. For both isoforms, our results show (1) a change in gene expression under OA (2) an effect of OA and temperature on carbonic anhydrase activity. We suggest that temperature increase could counterbalance the effect of OA on enzyme activity. Finally we point out that caution must, thus, be taken when interpreting transcriptomic data on carbonic anhydrases in ocean acidification and temperature stress experiments, as the effect of these stressors on the physiological function of CA will depend both on gene expression and enzyme activity.

Investigating Undergraduate Science Students' Conceptions and Misconceptions of Ocean Acidification.

PubMed

Danielson, Kathryn I; Tanner, Kimberly D

2015-01-01

Scientific research exploring ocean acidification has grown significantly in past decades. However, little science education research has investigated the extent to which undergraduate science students understand this topic. Of all undergraduate students, one might predict science students to be best able to understand ocean acidification. What conceptions and misconceptions of ocean acidification do these students hold? How does their awareness and knowledge compare across disciplines? Undergraduate biology, chemistry/biochemistry, and environmental studies students, and science faculty for comparison, were assessed on their awareness and understanding. Results revealed low awareness and understanding of ocean acidification among students compared with faculty. Compared with biology or chemistry/biochemistry students, more environmental studies students demonstrated awareness of ocean acidification and identified the key role of carbon dioxide. Novel misconceptions were also identified. These findings raise the question of whether undergraduate science students are prepared to navigate socioenvironmental issues such as ocean acidification. © 2015 K. I. Danielson and K. D. Tanner. CBE—Life Sciences Education © 2015 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Response of Ocean Circulation to Different Wind Forcing in Puerto Rico and US Virgin Islands

NASA Astrophysics Data System (ADS)

Solano, Miguel; Garcia, Edgardo; Leonardi, Stafano; Canals, Miguel; Capella, Jorge

2013-11-01

The response of the ocean circulation to various wind forcing products has been studied using the Regional Ocean Modeling System. The computational domain includes the main islands of Puerto Rico, Saint John and Saint Thomas, located on the continental shelf dividing the Caribbean Sea and the Atlantic Ocean. Data for wind forcing is provided by an anemometer located in a moored buoy, the Coupled Ocean-Atmosphere Mesoscale Prediction System (COAMPS) model and the National Digital Forecast Database (NDFD). Hindcast simulations have been validated using hydrographic data at different locations in the area of study. Three cases are compared to quantify the impact of high resolution wind forcing on the ocean circulation and the vertical structure of salinity, temperature and velocity. In the first case a constant wind velocity field is used to force the model as measured by an anemometer on top of a buoy. In the second case, a forcing field provided by the Navy's COAMPS model is used and in the third case, winds are taken from NDFD in collaboration with the National Centers for Environmental Prediction. Validated results of ocean currents against data from Acoustic Doppler Current Profilers at different locations show better agreement using high resolution wind data as expected. Thanks to CariCOOS and NOAA.

Assimilation of Satellite Sea Surface Salinity Fields: Validating Ocean Analyses and Identifying Errors in Surface Buoyancy Fluxes

NASA Astrophysics Data System (ADS)

Mehra, A.; Nadiga, S.; Bayler, E. J.; Behringer, D.

2014-12-01

Recently available satellite sea-surface salinity (SSS) fields provide an important new global data stream for assimilation into ocean forecast systems. In this study, we present results from assimilating satellite SSS fields from NASA's Aquarius mission into the National Oceanic and Atmospheric Administration's (NOAA) operational Modular Ocean Model version 4 (MOM4), the oceanic component of NOAA's operational seasonal-interannual Climate Forecast System (CFS). Experiments on the sensitivity of the ocean's overall state to different relaxation time periods were run to evaluate the importance of assimilating high-frequency (daily to mesoscale) and low-frequency (seasonal) SSS variability. Aquarius SSS data (Aquarius Data Processing System (ADPS) version 3.0), mapped daily fields at 1-degree spatial resolution, were used. Four model simulations were started from the same initial ocean condition and forced with NOAA's daily Climate Forecast System Reanalysis (CFSR) fluxes, using a relaxation technique to assimilate daily satellite sea surface temperature (SST) fields and selected SSS fields, where, except as noted, a 30-day relaxation period is used. The simulations are: (1) WOAMC, the reference case and similar to the operational setup, assimilating monthly climatological SSS from the 2009 NOAA World Ocean Atlas; (2) AQ_D, assimilating daily Aquarius SSS; (3) AQ_M, assimilating monthly Aquarius SSS; and (4) AQ_D10, assimilating daily Aquarius SSS, but using a 10-day relaxation period. The analysis focuses on the tropical Pacific Ocean, where the salinity dynamics are intense and dominated by El Niño interannual variability in the cold tongue region and by high-frequency precipitation events in the western Pacific warm pool region. To assess the robustness of results and conclusions, we also examine the results for the tropical Atlantic and Indian Oceans. Preliminary validation studies are conducted using observations, such as satellite sea-surface height (SSH) fields and in situ Argo buoy vertical profiles of temperature and salinity, to demonstrate that SSS data assimilation improves ocean state representation of the following variables: ocean heat content (0-300m), dynamic height (0-1000m), mixed-layer depth, sea surface heigh, and surface buoyancy fluxes.

On the Use of Satellite Altimetry to Detect Ocean Circulation's Magnetic Signals

NASA Astrophysics Data System (ADS)

Saynisch, J.; Irrgang, C.; Thomas, M.

2018-03-01

Oceanic magnetic signals are sensitive to ocean velocity, salinity, and heat content. The detection of respective signals with global satellite magnetometers would pose a very valuable source of information. While tidal magnetic fields are already detected, electromagnetic signals of the ocean circulation still remain unobserved from space. We propose to use satellite altimetry to construct proxy magnetic signals of the ocean circulation. These proxy time series could subsequently be fitted to satellite magnetometer data. The fitted data could be removed from the observations or the fitting constants could be analyzed for physical properties of the ocean, e.g., the heat budget. To test and evaluate this approach, synthetic true and proxy magnetic signals are derived from a global circulation model of the ocean. Both data sets are compared in dependence of location and time scale. We study and report when and where the proxy data describe the true signal sufficiently well. Correlations above 0.6 and explained variances of above 80% can be reported for large parts of the Antarctic ocean, thus explaining the major part of the global, subseasonal magnetic signal.