Loss model for off-design performance analysis of radial turbines with pivoting-vane, variable-area stators

NASA Technical Reports Server (NTRS)

Meitner, P. L.; Glassman, A. J.

1980-01-01

An off-design performance loss model for a radial turbine with pivoting, variable-area stators is developed through a combination of analytical modeling and experimental data analysis. A viscous loss model is used for the variation in stator loss with setting angle, and stator vane end-clearance leakage effects are predicted by a clearance flow model. The variation of rotor loss coefficient with stator setting angle is obtained by means of an analytical matching of experimental data for a rotor that was tested with six stators, having throat areas from 20 to 144% of the design area. An incidence loss model is selected to obtain best agreement with experimental data. The stator vane end-clearance leakage model predicts increasing mass flow and decreasing efficiency as a result of end-clearances, with changes becoming significantly larger with decreasing stator area.

Computational Assessment of the Aerodynamic Performance of a Variable-Speed Power Turbine for Large Civil Tilt-Rotor Application

NASA Technical Reports Server (NTRS)

Welch, Gerard E.

2011-01-01

The main rotors of the NASA Large Civil Tilt-Rotor notional vehicle operate over a wide speed-range, from 100% at take-off to 54% at cruise. The variable-speed power turbine offers one approach by which to effect this speed variation. Key aero-challenges include high work factors at cruise and wide (40 to 60 deg.) incidence variations in blade and vane rows over the speed range. The turbine design approach must optimize cruise efficiency and minimize off-design penalties at take-off. The accuracy of the off-design incidence loss model is therefore critical to the turbine design. In this effort, 3-D computational analyses are used to assess the variation of turbine efficiency with speed change. The conceptual design of a 4-stage variable-speed power turbine for the Large Civil Tilt-Rotor application is first established at the meanline level. The design of 2-D airfoil sections and resulting 3-D blade and vane rows is documented. Three-dimensional Reynolds Averaged Navier-Stokes computations are used to assess the design and off-design performance of an embedded 1.5-stage portion-Rotor 1, Stator 2, and Rotor 2-of the turbine. The 3-D computational results yield the same efficiency versus speed trends predicted by meanline analyses, supporting the design choice to execute the turbine design at the cruise operating speed.

Model predictive control design for polytopic uncertain systems by synthesising multi-step prediction scenarios

NASA Astrophysics Data System (ADS)

Lu, Jianbo; Xi, Yugeng; Li, Dewei; Xu, Yuli; Gan, Zhongxue

2018-01-01

A common objective of model predictive control (MPC) design is the large initial feasible region, low online computational burden as well as satisfactory control performance of the resulting algorithm. It is well known that interpolation-based MPC can achieve a favourable trade-off among these different aspects. However, the existing results are usually based on fixed prediction scenarios, which inevitably limits the performance of the obtained algorithms. So by replacing the fixed prediction scenarios with the time-varying multi-step prediction scenarios, this paper provides a new insight into improvement of the existing MPC designs. The adopted control law is a combination of predetermined multi-step feedback control laws, based on which two MPC algorithms with guaranteed recursive feasibility and asymptotic stability are presented. The efficacy of the proposed algorithms is illustrated by a numerical example.

An Experimental and Theoretical Study on Cavitating Propellers.

DTIC Science & Technology

1982-10-01

34 And Identfyp eV &to" nMeeJ cascade flow theoretical supercavitating flow performance prediction method partially cavitating flow supercavitating ...the present work was to develop an analytical tool for predicting the off-design performance of supercavitating propellers over a wide range of...operating conditions. Due to the complex nature of the flow phenomena, a lifting line theory sirply combined with the two-dimensional supercavitating

SEASAT economic assessment. Volume 2: The SEASAT system description and performance. [performance prediction and systems analysis for seasat satellites

NASA Technical Reports Server (NTRS)

1975-01-01

Results are presented of preliminary trade-off studies of operational SEASAT systems. The trade-off studies were used as the basis for the estimation of costs and net benefits of the operational SEASAT system. Also presented are the preliminary results of simulation studies that were designed to lead to a measure of the impact of SEASAT data through the use of numerical weather forecast models.

Off-design performance loss model for radial turbines with pivoting, variable-area stators

NASA Technical Reports Server (NTRS)

Meitner, P. L.; Glassman, A. J.

1980-01-01

An off-design performance loss model was developed for variable stator (pivoted vane), radial turbines through analytical modeling and experimental data analysis. Stator loss is determined by a viscous loss model; stator vane end-clearance leakage effects are determined by a clearance flow model. Rotor loss coefficient were obtained by analyzing the experimental data from a turbine rotor previously tested with six stators having throat areas from 20 to 144 percent of design area and were correlated with stator-to-rotor throat area ratio. An incidence loss model was selected to obtain best agreement with experimental results. Predicted turbine performance is compared with experimental results for the design rotor as well as with results for extended and cutback versions of the rotor. Sample calculations were made to show the effects of stator vane end-clearance leakage.

An evaluation of 1D loss model collections for the off-design performance prediction of automotive turbocharger compressors

NASA Astrophysics Data System (ADS)

Harley, P.; Spence, S.; Early, J.; Filsinger, D.; Dietrich, M.

2013-12-01

Single-zone modelling is used to assess different collections of impeller 1D loss models. Three collections of loss models have been identified in literature, and the background to each of these collections is discussed. Each collection is evaluated using three modern automotive turbocharger style centrifugal compressors; comparisons of performance for each of the collections are made. An empirical data set taken from standard hot gas stand tests for each turbocharger is used as a baseline for comparison. Compressor range is predicted in this study; impeller diffusion ratio is shown to be a useful method of predicting compressor surge in 1D, and choke is predicted using basic compressible flow theory. The compressor designer can use this as a guide to identify the most compatible collection of losses for turbocharger compressor design applications. The analysis indicates the most appropriate collection for the design of automotive turbocharger centrifugal compressors.

The Impeller Exit Flow Coefficient As a Performance Map Variable for Predicting Centrifugal Compressor Off-Design Operation Applied to a Supercritical CO 2 Working Fluid

DOE PAGES

Liese, Eric; Zitney, Stephen E.

2017-06-26

A multi-stage centrifugal compressor model is presented with emphasis on analyzing use of an exit flow coefficient vs. an inlet flow coefficient performance parameter to predict off-design conditions in the critical region of a supercritical carbon dioxide (CO 2) power cycle. A description of the performance parameters is given along with their implementation in a design model (number of stages, basic sizing, etc.) and a dynamic model (for use in transient studies). A design case is shown for two compressors, a bypass compressor and a main compressor, as defined in a process simulation of a 10 megawatt (MW) supercritical COmore » 2 recompression Brayton cycle. Simulation results are presented for a simple open cycle and closed cycle process with changes to the inlet temperature of the main compressor which operates near the CO 2 critical point. Results showed some difference in results using the exit vs. inlet flow coefficient correction, however, it was not significant for the range of conditions examined. Here, this paper also serves as a reference for future works, including a full process simulation of the 10 MW recompression Brayton cycle.« less

The Impeller Exit Flow Coefficient As a Performance Map Variable for Predicting Centrifugal Compressor Off-Design Operation Applied to a Supercritical CO 2 Working Fluid

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liese, Eric; Zitney, Stephen E.

A multi-stage centrifugal compressor model is presented with emphasis on analyzing use of an exit flow coefficient vs. an inlet flow coefficient performance parameter to predict off-design conditions in the critical region of a supercritical carbon dioxide (CO 2) power cycle. A description of the performance parameters is given along with their implementation in a design model (number of stages, basic sizing, etc.) and a dynamic model (for use in transient studies). A design case is shown for two compressors, a bypass compressor and a main compressor, as defined in a process simulation of a 10 megawatt (MW) supercritical COmore » 2 recompression Brayton cycle. Simulation results are presented for a simple open cycle and closed cycle process with changes to the inlet temperature of the main compressor which operates near the CO 2 critical point. Results showed some difference in results using the exit vs. inlet flow coefficient correction, however, it was not significant for the range of conditions examined. Here, this paper also serves as a reference for future works, including a full process simulation of the 10 MW recompression Brayton cycle.« less

HabEx Optical Telescope Concepts: Design and Performance Analysis

NASA Astrophysics Data System (ADS)

Stahl, H. Philip; NASA MSFC HabEx Telescope Design Team

2018-01-01

The Habitable-Exoplanet Imaging Mission (HabEx) engineering study team has been tasked by NASA with developing a compelling and feasible exoplanet direct imaging concept as part of the 2020 Decadal Survey. This paper summarizes design concepts for two off-axis unobscured telescope concepts: a 4-meter monolithic aperture and a 6-meter segmented aperutre. HabEx telescopes are designed for launch vehicle accommodation. Analysis includes prediction of on-orbit dynamic structural and thermal optical performance.

New technology in turbine aerodynamics.

NASA Technical Reports Server (NTRS)

Glassman, A. J.; Moffitt, T. P.

1972-01-01

Cursory review of some recent work that has been done in turbine aerodynamic research. Topics discussed include the aerodynamic effect of turbine coolant, high work-factor (ratio of stage work to square of blade speed) turbines, and computer methods for turbine design and performance prediction. Experimental cooled-turbine aerodynamics programs using two-dimensional cascades, full annular cascades, and cold rotating turbine stage tests are discussed with some typical results presented. Analytically predicted results for cooled blade performance are compared to experimental results. The problems and some of the current programs associated with the use of very high work factors for fan-drive turbines of high-bypass-ratio engines are discussed. Computer programs have been developed for turbine design-point performance, off-design performance, supersonic blade profile design, and the calculation of channel velocities for subsonic and transonic flowfields. The use of these programs for the design and analysis of axial and radial turbines is discussed.

Atomic defects in monolayer WSe2 tunneling FETs studied by systematic ab initio calculations

NASA Astrophysics Data System (ADS)

Wu, Jixuan; Fan, Zhiqiang; Chen, Jiezhi; Jiang, Xiangwei

2018-05-01

Atomic defects in monolayer WSe2 tunneling FETs (TFETs) are studied through systematic ab initio calculations aiming at performance predictions and enhancements. The effects of various defect positions and different passivation atoms are characterized in WSe2 TFETs by rigorous ab initio quantum transport simulations. It is suggested that the Se vacancy (VSe) defect located in the gate-controlled channel region tends to increase the OFF current (I off), whereas it can be well suppressed by oxygen passivation. It is demonstrated that chlorine (Cl) passivation at the source-side tunneling region can largely suppress I off, leading to an impressively improved on–off ratio (I on/I off) compared with that without any defect. However, it is also observed that randomly positioned atomic defects tend to induce significant fluctuation of the TFET output. Further discussions are made with focus on the performance-variability trade-off for robust circuit design.

Predicting Pilot Performance in Off-Nominal Conditions: A Meta-Analysis and Model Validation

NASA Technical Reports Server (NTRS)

Wickens, C.D.; Hooey, B.L.; Gore, B.F.; Sebok, A.; Koenecke, C.; Salud, E.

2009-01-01

Pilot response to off-nominal (very rare) events represents a critical component to understanding the safety of next generation airspace technology and procedures. We describe a meta-analysis designed to integrate the existing data regarding pilot accuracy of detecting rare, unexpected events such as runway incursions in realistic flight simulations. Thirty-five studies were identified and pilot responses were categorized by expectancy, event location, and whether the pilot was flying with a highway-in-the-sky display. All three dichotomies produced large, significant effects on event miss rate. A model of human attention and noticing, N-SEEV, was then used to predict event noticing performance as a function of event salience and expectancy, and retinal eccentricity. Eccentricity is predicted from steady state scanning by the SEEV model of attention allocation. The model was used to predict miss rates for the expectancy, location and highway-in-the-sky (HITS) effects identified in the meta-analysis. The correlation between model-predicted results and data from the meta-analysis was 0.72.

Large-Scale Off-Target Identification Using Fast and Accurate Dual Regularized One-Class Collaborative Filtering and Its Application to Drug Repurposing.

PubMed

Lim, Hansaim; Poleksic, Aleksandar; Yao, Yuan; Tong, Hanghang; He, Di; Zhuang, Luke; Meng, Patrick; Xie, Lei

2016-10-01

Target-based screening is one of the major approaches in drug discovery. Besides the intended target, unexpected drug off-target interactions often occur, and many of them have not been recognized and characterized. The off-target interactions can be responsible for either therapeutic or side effects. Thus, identifying the genome-wide off-targets of lead compounds or existing drugs will be critical for designing effective and safe drugs, and providing new opportunities for drug repurposing. Although many computational methods have been developed to predict drug-target interactions, they are either less accurate than the one that we are proposing here or computationally too intensive, thereby limiting their capability for large-scale off-target identification. In addition, the performances of most machine learning based algorithms have been mainly evaluated to predict off-target interactions in the same gene family for hundreds of chemicals. It is not clear how these algorithms perform in terms of detecting off-targets across gene families on a proteome scale. Here, we are presenting a fast and accurate off-target prediction method, REMAP, which is based on a dual regularized one-class collaborative filtering algorithm, to explore continuous chemical space, protein space, and their interactome on a large scale. When tested in a reliable, extensive, and cross-gene family benchmark, REMAP outperforms the state-of-the-art methods. Furthermore, REMAP is highly scalable. It can screen a dataset of 200 thousands chemicals against 20 thousands proteins within 2 hours. Using the reconstructed genome-wide target profile as the fingerprint of a chemical compound, we predicted that seven FDA-approved drugs can be repurposed as novel anti-cancer therapies. The anti-cancer activity of six of them is supported by experimental evidences. Thus, REMAP is a valuable addition to the existing in silico toolbox for drug target identification, drug repurposing, phenotypic screening, and side effect prediction. The software and benchmark are available at https://github.com/hansaimlim/REMAP.

Large-Scale Off-Target Identification Using Fast and Accurate Dual Regularized One-Class Collaborative Filtering and Its Application to Drug Repurposing

PubMed Central

Poleksic, Aleksandar; Yao, Yuan; Tong, Hanghang; Meng, Patrick; Xie, Lei

2016-01-01

Target-based screening is one of the major approaches in drug discovery. Besides the intended target, unexpected drug off-target interactions often occur, and many of them have not been recognized and characterized. The off-target interactions can be responsible for either therapeutic or side effects. Thus, identifying the genome-wide off-targets of lead compounds or existing drugs will be critical for designing effective and safe drugs, and providing new opportunities for drug repurposing. Although many computational methods have been developed to predict drug-target interactions, they are either less accurate than the one that we are proposing here or computationally too intensive, thereby limiting their capability for large-scale off-target identification. In addition, the performances of most machine learning based algorithms have been mainly evaluated to predict off-target interactions in the same gene family for hundreds of chemicals. It is not clear how these algorithms perform in terms of detecting off-targets across gene families on a proteome scale. Here, we are presenting a fast and accurate off-target prediction method, REMAP, which is based on a dual regularized one-class collaborative filtering algorithm, to explore continuous chemical space, protein space, and their interactome on a large scale. When tested in a reliable, extensive, and cross-gene family benchmark, REMAP outperforms the state-of-the-art methods. Furthermore, REMAP is highly scalable. It can screen a dataset of 200 thousands chemicals against 20 thousands proteins within 2 hours. Using the reconstructed genome-wide target profile as the fingerprint of a chemical compound, we predicted that seven FDA-approved drugs can be repurposed as novel anti-cancer therapies. The anti-cancer activity of six of them is supported by experimental evidences. Thus, REMAP is a valuable addition to the existing in silico toolbox for drug target identification, drug repurposing, phenotypic screening, and side effect prediction. The software and benchmark are available at https://github.com/hansaimlim/REMAP. PMID:27716836

A numerical study on the thermal initiation of a confined explosive in 2-D geometry.

PubMed

Aydemir, Erdoğan; Ulas, Abdullah

2011-02-15

Insensitive munitions design against thermal stimuli like slow or fast cook-off has become a significant requirement for today's munitions. In order to achieve insensitive munitions characteristics, the response of the energetic material needs to be predicted against heating stimuli. In this study, a 2D numerical code was developed to simulate the slow and fast cook-off heating conditions of confined munitions and to obtain the response of the energetic materials. Computations were performed in order to predict the transient temperature distribution, the ignition time, and the location of ignition in the munitions. These predictions enable the designers to have an idea of when and at which location the energetic material ignites under certain adverse surrounding conditions. In the paper, the development of the code is explained and the numerical results are compared with available experimental and numerical data in the literature. Additionally, a parametric study was performed showing the effect of dimensional scaling of munitions and the heating rate on the ignition characteristics. Copyright © 2010 Elsevier B.V. All rights reserved.

FORTRAN program for predicting off-design performance of radial-inflow turbines

NASA Technical Reports Server (NTRS)

Wasserbauer, C. A.; Glassman, A. J.

1975-01-01

The FORTRAN IV program uses a one-dimensional solution of flow conditions through the turbine along the mean streamline. The program inputs needed are the design-point requirements and turbine geometry. The output includes performance and velocity-diagram parameters over a range of speed and pressure ratio. Computed performance is compared with the experimental data from two radial-inflow turbines and with the performance calculated by a previous computer program. The flow equations, program listing, and input and output for a sample problem are given.

Comparison of a quasi-3D analysis and experimental performance for three compact radial turbines

NASA Technical Reports Server (NTRS)

Simonyi, P. S.; Boyle, R. J.

1991-01-01

An experimental aerodynamic evaluation of three compact radial turbine builds was performed. Two rotors which were 40-50 percent shorter in axial length than conventional state-of-the-art radial rotors were tested. A single nozzle design was used. One rotor was tested with the nozzle at two stagger angle settings. A second rotor was tested with the nozzle in only the closed down setting. Experimental results were compared to predicted results from a quasi-3D inviscid and boundary layer analysis, called MTSB (Meridl/Tsonic/Blayer). This analysis was used to predict turbine performance. It has previously been calibrated only for axial, not radial, turbomachinery. The predicted and measured efficiencies were compared at the design point for the three turbines. At the design points the analysis overpredicted the efficiency by less than 1.7 points. Comparisons were also made at off-design operating points. The results of these comparisons showed the importance of an accurate clearance model for efficiency predictions and also that there are deficiencies in the incidence loss model used.

Comparison of a quasi-3D analysis and experimental performance for three compact radial turbines

NASA Technical Reports Server (NTRS)

Simonyi, P. S.; Boyle, R. J.

1991-01-01

An experimental aerodynamic evaluation of three compact radial turbine builds was performed. Two rotors which were 40 to 50 percent shorter in axial length than conventional state of the art radial rotors were tested. A single nozzle design was used. One rotor was tested with the nozzle at two stagger angle settings. A second rotor was tested with the nozzle in only the closed down setting. Experimental results were compared to predict results from a quasi-3D inviscid and boundary layer analysis, called Meridl/Tsonic/Blayer (MTSB). This analysis was used to predict turbine performance. It has previously been calibrated only for axial, not radial, turbomachinery. The predicted and measured efficiencies were compared at the design point for the three turbines. At the design points the analysis overpredicted the efficiency by less than 1.7 points. Comparisons were also made at off-design operating points. The results of these comparisons showed the importance of an accurate clearance model for efficiency predictions and also that there are deficiencies in the incidence loss model used.

Planetary Suit Hip Bearing Model for Predicting Design vs. Performance

NASA Technical Reports Server (NTRS)

Cowley, Matthew S.; Margerum, Sarah; Harvil, Lauren; Rajulu, Sudhakar

2011-01-01

Designing a planetary suit is very complex and often requires difficult trade-offs between performance, cost, mass, and system complexity. In order to verifying that new suit designs meet requirements, full prototypes must eventually be built and tested with human subjects. Using computer models early in the design phase of new hardware development can be advantageous, allowing virtual prototyping to take place. Having easily modifiable models of the suit hard sections may reduce the time it takes to make changes to the hardware designs and then to understand their impact on suit and human performance. A virtual design environment gives designers the ability to think outside the box and exhaust design possibilities before building and testing physical prototypes with human subjects. Reductions in prototyping and testing may eventually reduce development costs. This study is an attempt to develop computer models of the hard components of the suit with known physical characteristics, supplemented with human subject performance data. Objectives: The primary objective was to develop an articulating solid model of the Mark III hip bearings to be used for evaluating suit design performance of the hip joint. Methods: Solid models of a planetary prototype (Mark III) suit s hip bearings and brief section were reverse-engineered from the prototype. The performance of the models was then compared by evaluating the mobility performance differences between the nominal hardware configuration and hardware modifications. This was accomplished by gathering data from specific suited tasks. Subjects performed maximum flexion and abduction tasks while in a nominal suit bearing configuration and in three off-nominal configurations. Performance data for the hip were recorded using state-of-the-art motion capture technology. Results: The results demonstrate that solid models of planetary suit hard segments for use as a performance design tool is feasible. From a general trend perspective, the suited performance trends were comparable between the model and the suited subjects. With the three off-nominal bearing configurations compared to the nominal bearing configurations, human subjects showed decreases in hip flexion of 64%, 6%, and 13% and in hip abduction of 59%, 2%, and 20%. Likewise the solid model showed decreases in hip flexion of 58%, 1%, and 25% and in hip abduction of 56%, 0%, and 30%, under the same condition changes from the nominal configuration. Differences seen between the model predictions and the human subject performance data could be attributed to the model lacking dynamic elements and performing kinematic analysis only, the level of fit of the subjects with the suit, the levels of the subject s suit experience.

Off-design performance analysis of MHD generator channels

NASA Technical Reports Server (NTRS)

Wilson, D. R.; Williams, T. S.

1980-01-01

A computer code for performing parametric design point calculations, and evaluating the off-design performance of MHD generators has been developed. The program is capable of analyzing Faraday, Hall, and DCW channels, including the effect of electrical shorting in the gas boundary layers and coal slag layers. Direct integration of the electrode voltage drops is included. The program can be run in either the design or off-design mode. Details of the computer code, together with results of a study of the design and off-design performance of the proposed ETF MHD generator are presented. Design point variations of pre-heat and stoichiometry were analyzed. The off-design study included variations in mass flow rate and oxygen enrichment.

One way Doppler extractor. Volume 1: Vernier technique

NASA Technical Reports Server (NTRS)

Blasco, R. W.; Klein, S.; Nossen, E. J.; Starner, E. R.; Yanosov, J. A.

1974-01-01

A feasibility analysis, trade-offs, and implementation for a One Way Doppler Extraction system are discussed. A Doppler error analysis shows that quantization error is a primary source of Doppler measurement error. Several competing extraction techniques are compared and a Vernier technique is developed which obtains high Doppler resolution with low speed logic. Parameter trade-offs and sensitivities for the Vernier technique are analyzed, leading to a hardware design configuration. A detailed design, operation, and performance evaluation of the resulting breadboard model is presented which verifies the theoretical performance predictions. Performance tests have verified that the breadboard is capable of extracting Doppler, on an S-band signal, to an accuracy of less than 0.02 Hertz for a one second averaging period. This corresponds to a range rate error of no more than 3 millimeters per second.

Grayscale/resolution trade-off for text: Model predictions and psychophysical results for letter confusion and letter discrimination

NASA Technical Reports Server (NTRS)

Gille, Jennifer; Martin, Russel; Lubin, Jeffrey; Larimer, James

1995-01-01

In a series of papers presented in 1994, we examined the grayscale/resolution trade-off for natural images displayed on devices with discrete pixellation, such as AMLCD's. In the present paper we extend this study by examining the grayscale/resolution trade-off for text images on discrete-pixel displays. Halftoning in printing is an example of the grayscale/resolution trade-off. In printing, spatial resolution is sacrificed to produce grayscale. Another example of this trade-off is the inherent low-pass spatial filter of a CRT, caused by the point-spread function of the electron beam in the phosphor layer. On a CRT, sharp image edges are blurred by this inherent low-pass filtering, and the block noise created by spatial quantization is greatly reduced. A third example of this trade-off is text anti-aliasing, where grayscale is used to improve letter shape, size and location when rendered at a low spatial resolution. There are additional implications for display system design from the grayscale/resolution trade-off. For example, reduced grayscale can reduce system costs by requiring less complexity in the framestore, allowing the use of lower cost drivers, potentially increasing data transfer rates in the image subsystem, and simplifying the manufacturing processes that are used to construct the active matrix for AMLCD (active-matrix liquid-crystal display) or AMTFEL (active-matrix thin-film electroluminescent) devices. Therefore, the study of these trade-offs is important for display designers and manufacturing and systems engineers who wish to create the highest performance, lowest cost device possible. Our strategy for investigating this trade-off is to generate a set of simple test images, manipulate grayscale and resolution, predict discrimination performance using the ViDEOS(Sarnoff) Human Vision Model, conduct an empirical study of discrimination using psychophysical procedures, and verify the computational results using the psychophysical results.

Cryogenic and thermal design for the Superfluid Helium On-Orbit Transfer (SHOOT) experiment

NASA Technical Reports Server (NTRS)

Lee, J. H.; Maa, S.; Brooks, W. F.; Ng, Y. S.

1988-01-01

The analysis and trade-offs of the external thermal design of the two 200-liter dewars required in the SHOOT experiment to extend space mission life by superfluid helium replenishment are discussed. Also considered are the support electronics and the optimization and prediction of the performance of the dewar and cryostat assemblies. Particular attention is given to the ground-hold and standby performance of the dewars, along with the temperature of the helium bath during high-flow-rate helium transfers.

A model for prediction of STOVL ejector dynamics

NASA Technical Reports Server (NTRS)

Drummond, Colin K.

1989-01-01

A semi-empirical control-volume approach to ejector modeling for transient performance prediction is presented. This new approach is motivated by the need for a predictive real-time ejector sub-system simulation for Short Take-Off Verticle Landing (STOVL) integrated flight and propulsion controls design applications. Emphasis is placed on discussion of the approximate characterization of the mixing process central to thrust augmenting ejector operation. The proposed ejector model suggests transient flow predictions are possible with a model based on steady-flow data. A practical test case is presented to illustrate model calibration.

Dynamic/Jitter Assessment of Multiple Potential HabEx Structural Designs

NASA Technical Reports Server (NTRS)

Knight, J. Brent; Stahl, H. Philip; Singleton, Andy; Hunt, Ron; Therrell, Melissa; Caldwell, Kate; Garcia, Jay; Baysinger, Mike

2017-01-01

One of the driving structural requirements of the Habitable Exo-Planet (HabEx) telescope is to maintain Line Of Sight (LOS) stability between the Primary Mirror (PM) and Secondary Mirror (SM) of = 5 mas. Dynamic analyses of two configurations of a proposed (HabEx) 4 meter off-axis telescope structure were performed to predict effects of jitter on primary/secondary mirror alignment. The dynamic disturbance used as the forcing function was the James Webb Space Telescope reaction wheel assembly vibration emission specification level. The objective of these analyses was to predict "order-of-magnitude" performance for various structural configurations which will roll into efforts to define the HabEx structural design's global architecture. Two variations of the basic architectural design were analyzed. Relative motion between the PM and the SM for each design configuration are reported.

Dynamic/jitter assessment of multiple potential HabEx structural designs

NASA Astrophysics Data System (ADS)

Knight, J. Brent; Stahl, H. Philip; Singleton, Andy; Hunt, Ron; Therrell, Melissa; Caldwell, Kate; Garcia, Jay; Baysinger, Mike

2017-09-01

One of the driving structural requirements of the Habitable Exo-Planet (HabEx) telescope is to maintain Line Of Sight (LOS) stability between the Primary Mirror (PM) and Secondary Mirror (SM) of <= 5 milli-arc seconds (mas). Dynamic analyses of two configurations of a proposed HabEx 4 meter off-axis telescope structure were performed to predict effects of a vibration input on primary/secondary mirror alignment. The dynamic disturbance used as the forcing function was the James Webb Space Telescope reaction wheel assembly vibration emission specification level. The objective of these analyses was to predict "order-of-magnitude" performance for various structural configurations which contribute to efforts in defining the HabEx structural design's global architecture. Two variations of the basic architectural design were analyzed. Relative motion between the PM and the SM for each design configuration are reported.

New technology in turbine aerodynamics

NASA Technical Reports Server (NTRS)

Glassman, A. J.; Moffitt, T. P.

1972-01-01

A cursory review is presented of some of the recent work that has been done in turbine aerodynamic research at NASA-Lewis Research Center. Topics discussed include the aerodynamic effect of turbine coolant, high work-factor (ratio of stage work to square of blade speed) turbines, and computer methods for turbine design and performance prediction. An extensive bibliography is included. Experimental cooled-turbine aerodynamics programs using two-dimensional cascades, full annular cascades, and cold rotating turbine stage tests are discussed with some typical results presented. Analytically predicted results for cooled blade performance are compared to experimental results. The problems and some of the current programs associated with the use of very high work factors for fan-drive turbines of high-bypass-ratio engines are discussed. Turbines currently being investigated make use of advanced blading concepts designed to maintain high efficiency under conditions of high aerodynamic loading. Computer programs have been developed for turbine design-point performance, off-design performance, supersonic blade profile design, and the calculation of channel velocities for subsonic and transonic flow fields. The use of these programs for the design and analysis of axial and radial turbines is discussed.

Miscellaneous Topics in Computer-Aided Drug Design: Synthetic Accessibility and GPU Computing, and Other Topics.

PubMed

Fukunishi, Yoshifumi; Mashimo, Tadaaki; Misoo, Kiyotaka; Wakabayashi, Yoshinori; Miyaki, Toshiaki; Ohta, Seiji; Nakamura, Mayu; Ikeda, Kazuyoshi

2016-01-01

Computer-aided drug design is still a state-of-the-art process in medicinal chemistry, and the main topics in this field have been extensively studied and well reviewed. These topics include compound databases, ligand-binding pocket prediction, protein-compound docking, virtual screening, target/off-target prediction, physical property prediction, molecular simulation and pharmacokinetics/pharmacodynamics (PK/PD) prediction. Message and Conclusion: However, there are also a number of secondary or miscellaneous topics that have been less well covered. For example, methods for synthesizing and predicting the synthetic accessibility (SA) of designed compounds are important in practical drug development, and hardware/software resources for performing the computations in computer-aided drug design are crucial. Cloud computing and general purpose graphics processing unit (GPGPU) computing have been used in virtual screening and molecular dynamics simulations. Not surprisingly, there is a growing demand for computer systems which combine these resources. In the present review, we summarize and discuss these various topics of drug design.

Miscellaneous Topics in Computer-Aided Drug Design: Synthetic Accessibility and GPU Computing, and Other Topics

PubMed Central

Fukunishi, Yoshifumi; Mashimo, Tadaaki; Misoo, Kiyotaka; Wakabayashi, Yoshinori; Miyaki, Toshiaki; Ohta, Seiji; Nakamura, Mayu; Ikeda, Kazuyoshi

2016-01-01

Abstract: Background Computer-aided drug design is still a state-of-the-art process in medicinal chemistry, and the main topics in this field have been extensively studied and well reviewed. These topics include compound databases, ligand-binding pocket prediction, protein-compound docking, virtual screening, target/off-target prediction, physical property prediction, molecular simulation and pharmacokinetics/pharmacodynamics (PK/PD) prediction. Message and Conclusion: However, there are also a number of secondary or miscellaneous topics that have been less well covered. For example, methods for synthesizing and predicting the synthetic accessibility (SA) of designed compounds are important in practical drug development, and hardware/software resources for performing the computations in computer-aided drug design are crucial. Cloud computing and general purpose graphics processing unit (GPGPU) computing have been used in virtual screening and molecular dynamics simulations. Not surprisingly, there is a growing demand for computer systems which combine these resources. In the present review, we summarize and discuss these various topics of drug design. PMID:27075578

Design and Test of a Transonic Axial Splittered Rotor

DTIC Science & Technology

2015-06-15

AXIAL SPLITTERED ROTOR A new design procedure was developed that uses commercial-off-the-shelf software (MATLAB, SolidWorks, and ANSYS-CFX) for the...geometric rendering and analysis of a transonic axial compressor rotor with splitter blades. Predictive numerical simulations were conducted and...Compressor, Splittered Rotor REPORT DOCUMENTATION PAGE 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 10. SPONSOR/MONITOR’S ACRONYM(S) ARO 8. PERFORMING

Mean Line Pump Flow Model in Rocket Engine System Simulation

NASA Technical Reports Server (NTRS)

Veres, Joseph P.; Lavelle, Thomas M.

2000-01-01

A mean line pump flow modeling method has been developed to provide a fast capability for modeling turbopumps of rocket engines. Based on this method, a mean line pump flow code PUMPA has been written that can predict the performance of pumps at off-design operating conditions, given the loss of the diffusion system at the design point. The pump code can model axial flow inducers, mixed-flow and centrifugal pumps. The code can model multistage pumps in series. The code features rapid input setup and computer run time, and is an effective analysis and conceptual design tool. The map generation capability of the code provides the map information needed for interfacing with a rocket engine system modeling code. The off-design and multistage modeling capabilities of the code permit parametric design space exploration of candidate pump configurations and provide pump performance data for engine system evaluation. The PUMPA code has been integrated with the Numerical Propulsion System Simulation (NPSS) code and an expander rocket engine system has been simulated. The mean line pump flow code runs as an integral part of the NPSS rocket engine system simulation and provides key pump performance information directly to the system model at all operating conditions.

Investigation of SSME alternate high pressure fuel turbopump lift-off seal fluid and structural dynamic interaction

NASA Technical Reports Server (NTRS)

Elrod, David A.

1989-01-01

The Space Shuttle main engine (SSME) alternate turbopump development program (ATD) high pressure fuel turbopump (HPFTP) design utilizes an innovative lift-off seal (LOS) design that is located in close proximity to the turbine end bearing. Cooling flow exiting the bearing passes through the lift-off seal during steady state operation. The potential for fluid excitation of lift-off seal structural resonances is investigated. No fluid excitation of LOS resonances is predicted. However, if predicted LOS natural frequencies are significantly lowered by the presence of the coolant, pressure oscillations caused by synchronous whirl of the HPFTP rotor may excite a resonance.

Design study and performance analysis of a high-speed multistage variable-geometry fan for a variable cycle engine

NASA Technical Reports Server (NTRS)

Sullivan, T. J.; Parker, D. E.

1979-01-01

A design technology study was performed to identify a high speed, multistage, variable geometry fan configuration capable of achieving wide flow modulation with near optimum efficiency at the important operating condition. A parametric screening study of the front and rear block fans was conducted in which the influence of major fan design features on weight and efficiency was determined. Key design parameters were varied systematically to determine the fan configuration most suited for a double bypass, variable cycle engine. Two and three stage fans were considered for the front block. A single stage, core driven fan was studied for the rear block. Variable geometry concepts were evaluated to provide near optimum off design performance. A detailed aerodynamic design and a preliminary mechanical design were carried out for the selected fan configuration. Performance predictions were made for the front and rear block fans.

A validation study of the simulation software gprMax by varying antenna stand-off height

NASA Astrophysics Data System (ADS)

Wilkinson, Josh; Davidson, Nigel

2018-04-01

The design and subsequent testing of suitable antennas and of complete ground-penetrating radar (GPR) systems can be both time consuming and expensive, with the need to understand the performance of a system in realistic environments of great importance to the end user. Through the use of suitably validated simulations, these costs could be significantly reduced, allowing an economical capability to be built which can accurately predict the performance of novel GPR antennas and existing commercial-off-the-shelf (COTS) systems in a user defined environment. This paper focuses on a preliminary validation of the open source software gprMax1 which features the ability to custom define antennas, targets, clutter objects and realistic heterogeneous soils. As an initial step in the assessment of the software, a comparison of the modelled response of targets buried in sand to experimental data has been undertaken, with the variation in response with antenna stand-off height investigated. This was conducted for both a simple bespoke bow-tie antenna design as well as for a Geophysical Survey Systems, Inc. (GSSI) commercial system,2 building upon previous work3 which explored the fidelity of gprMax in reproducing the S11 of simple antenna designs.

Computer Program for the Design and Off-Design Performance of Turbojet and Turbofan Engine Cycles

NASA Technical Reports Server (NTRS)

Morris, S. J.

1978-01-01

The rapid computer program is designed to be run in a stand-alone mode or operated within a larger program. The computation is based on a simplified one-dimensional gas turbine cycle. Each component in the engine is modeled thermo-dynamically. The component efficiencies used in the thermodynamic modeling are scaled for the off-design conditions from input design point values using empirical trends which are included in the computer code. The engine cycle program is capable of producing reasonable engine performance prediction with a minimum of computer execute time. The current computer execute time on the IBM 360/67 for one Mach number, one altitude, and one power setting is about 0.1 seconds. about 0.1 seconds. The principal assumption used in the calculation is that the compressor is operated along a line of maximum adiabatic efficiency on the compressor map. The fluid properties are computed for the combustion mixture, but dissociation is not included. The procedure included in the program is only for the combustion of JP-4, methane, or hydrogen.

Comparison Between Simulated and Experimentally Measured Performance of a Four Port Wave Rotor

NASA Technical Reports Server (NTRS)

Paxson, Daniel E.; Wilson, Jack; Welch, Gerard E.

2007-01-01

Performance and operability testing has been completed on a laboratory-scale, four-port wave rotor, of the type suitable for use as a topping cycle on a gas turbine engine. Many design aspects, and performance estimates for the wave rotor were determined using a time-accurate, one-dimensional, computational fluid dynamics-based simulation code developed specifically for wave rotors. The code follows a single rotor passage as it moves past the various ports, which in this reference frame become boundary conditions. This paper compares wave rotor performance predicted with the code to that measured during laboratory testing. Both on and off-design operating conditions were examined. Overall, the match between code and rig was found to be quite good. At operating points where there were disparities, the assumption of larger than expected internal leakage rates successfully realigned code predictions and laboratory measurements. Possible mechanisms for such leakage rates are discussed.

An approximate theoretical method for modeling the static thrust performance of non-axisymmetric two-dimensional convergent-divergent nozzles. M.S. Thesis - George Washington Univ.

NASA Technical Reports Server (NTRS)

Hunter, Craig A.

1995-01-01

An analytical/numerical method has been developed to predict the static thrust performance of non-axisymmetric, two-dimensional convergent-divergent exhaust nozzles. Thermodynamic nozzle performance effects due to over- and underexpansion are modeled using one-dimensional compressible flow theory. Boundary layer development and skin friction losses are calculated using an approximate integral momentum method based on the classic karman-Polhausen solution. Angularity effects are included with these two models in a computational Nozzle Performance Analysis Code, NPAC. In four different case studies, results from NPAC are compared to experimental data obtained from subscale nozzle testing to demonstrate the capabilities and limitations of the NPAC method. In several cases, the NPAC prediction matched experimental gross thrust efficiency data to within 0.1 percent at a design NPR, and to within 0.5 percent at off-design conditions.

Off-Ice Anaerobic Power Does Not Predict On-Ice Repeated Shift Performance in Hockey.

PubMed

Peterson, Ben J; Fitzgerald, John S; Dietz, Calvin C; Ziegler, Kevin S; Baker, Sarah E; Snyder, Eric M

2016-09-01

Peterson, BJ, Fitzgerald, JS, Dietz, CC, Ziegler, KS, Baker, SE, and Snyder, EM. Off-ice anaerobic power does not predict on-ice repeated shift performance in hockey. J Strength Cond Res 30(9): 2375-2381, 2016-Anaerobic power is a significant predictor of acceleration and top speed in team sport athletes. Historically, these findings have been applied to ice hockey although recent research has brought their validity for this sport into question. As ice hockey emphasizes the ability to repeatedly produce power, single bout anaerobic power tests should be examined to determine their ability to predict on-ice performance. We tested whether conventional off-ice anaerobic power tests could predict on-ice acceleration, top speed, and repeated shift performance. Forty-five hockey players, aged 18-24 years, completed anthropometric, off-ice, and on-ice tests. Anthropometric and off-ice testing included height, weight, body composition, vertical jump, and Wingate tests. On-ice testing consisted of acceleration, top speed, and repeated shift fatigue tests. Vertical jump (VJ) (r = -0.42; r = -0.58), Wingate relative peak power (WRPP) (r = -0.32; r = -0.43), and relative mean power (WRMP) (r = -0.34; r = -0.48) were significantly correlated (p ≤ 0.05) to on-ice acceleration and top speed, respectively. Conversely, none of the off-ice tests correlated with on-ice repeated shift performance, as measured by first gate, second gate, or total course fatigue; VJ (r = 0.06; r = 0.13; r = 0.09), WRPP (r = 0.06; r = 0.14; r = 0.10), or WRMP (r = -0.10; r = -0.01; r = -0.01). Although conventional off-ice anaerobic power tests predict single bout on-ice acceleration and top speed, they neither predict the repeated shift ability of the player, nor are good markers for performance in ice hockey.

Magnetostrictive direct drive motors

NASA Technical Reports Server (NTRS)

Naik, Dipak; Dehoff, P. H.

1990-01-01

Developing magnetostrictive direct drive research motors to power robot joints is discussed. These type motors are expected to produce extraordinary torque density, to be able to perform microradian incremental steps and to be self-braking and safe with the power off. Several types of motor designs have been attempted using magnetostrictive materials. One of the candidate approaches (the magnetostrictive roller drive) is described. The method in which the design will function is described as is the reason why this approach is inherently superior to the other approaches. Following this, the design will be modelled and its expected performance predicted. This particular candidate design is currently undergoing detailed engineering with prototype construction and testing scheduled for mid 1991.

Greased Lightning (GL-10) Performance Flight Research: Flight Data Report

NASA Technical Reports Server (NTRS)

McSwain, Robert G.; Glaab, Louis J.; Theodore, Colin R.; Rhew, Ray D. (Editor); North, David D. (Editor)

2017-01-01

Modern aircraft design methods have produced acceptable designs for large conventional aircraft performance. With revolutionary electronic propulsion technologies fueled by the growth in the small UAS (Unmanned Aerial Systems) industry, these same prediction models are being applied to new smaller, and experimental design concepts requiring a VTOL (Vertical Take Off and Landing) capability for ODM (On Demand Mobility). A 50% sub-scale GL-10 flight model was built and tested to demonstrate the transition from hover to forward flight utilizing DEP (Distributed Electric Propulsion)[1][2]. In 2016 plans were put in place to conduct performance flight testing on the 50% sub-scale GL-10 flight model to support a NASA project called DELIVER (Design Environment for Novel Vertical Lift Vehicles). DELIVER was investigating the feasibility of including smaller and more experimental aircraft configurations into a NASA design tool called NDARC (NASA Design and Analysis of Rotorcraft)[3]. This report covers the performance flight data collected during flight testing of the GL-10 50% sub-scale flight model conducted at Beaver Dam Airpark, VA. Overall the flight test data provides great insight into how well our existing conceptual design tools predict the performance of small scale experimental DEP concepts. Low fidelity conceptual design tools estimated the (L/D)( sub max)of the GL-10 50% sub-scale flight model to be 16. Experimentally measured (L/D)( sub max) for the GL-10 50% scale flight model was 7.2. The aerodynamic performance predicted versus measured highlights the complexity of wing and nacelle interactions which is not currently accounted for in existing low fidelity tools.

Evaluating Nextgen Closely Spaced Parallel Operations Concepts with Validated Human Performance Models: Flight Deck Guidelines

NASA Technical Reports Server (NTRS)

Hooey, Becky Lee; Gore, Brian Francis; Mahlstedt, Eric; Foyle, David C.

2013-01-01

The objectives of the current research were to develop valid human performance models (HPMs) of approach and land operations; use these models to evaluate the impact of NextGen Closely Spaced Parallel Operations (CSPO) on pilot performance; and draw conclusions regarding flight deck display design and pilot-ATC roles and responsibilities for NextGen CSPO concepts. This document presents guidelines and implications for flight deck display designs and candidate roles and responsibilities. A companion document (Gore, Hooey, Mahlstedt, & Foyle, 2013) provides complete scenario descriptions and results including predictions of pilot workload, visual attention and time to detect off-nominal events.

Optimize the Coverage Probability of Prediction Interval for Anomaly Detection of Sensor-Based Monitoring Series

PubMed Central

Liu, Datong; Peng, Yu; Peng, Xiyuan

2018-01-01

Effective anomaly detection of sensing data is essential for identifying potential system failures. Because they require no prior knowledge or accumulated labels, and provide uncertainty presentation, the probability prediction methods (e.g., Gaussian process regression (GPR) and relevance vector machine (RVM)) are especially adaptable to perform anomaly detection for sensing series. Generally, one key parameter of prediction models is coverage probability (CP), which controls the judging threshold of the testing sample and is generally set to a default value (e.g., 90% or 95%). There are few criteria to determine the optimal CP for anomaly detection. Therefore, this paper designs a graphic indicator of the receiver operating characteristic curve of prediction interval (ROC-PI) based on the definition of the ROC curve which can depict the trade-off between the PI width and PI coverage probability across a series of cut-off points. Furthermore, the Youden index is modified to assess the performance of different CPs, by the minimization of which the optimal CP is derived by the simulated annealing (SA) algorithm. Experiments conducted on two simulation datasets demonstrate the validity of the proposed method. Especially, an actual case study on sensing series from an on-orbit satellite illustrates its significant performance in practical application. PMID:29587372

Wave-Rotor-Enhanced Gas Turbine Engine Demonstrator

NASA Technical Reports Server (NTRS)

Welch, Gerard E.; Paxson, Daniel E.; Wilson, Jack; Synder, Philip H.

1999-01-01

The U.S. Army Research Laboratory, NASA Glenn Research Center, and Rolls-Royce Allison are working collaboratively to demonstrate the benefits and viability of a wave-rotor-topped gas turbine engine. The self-cooled wave rotor is predicted to increase the engine overall pressure ratio and peak temperature by 300% and 25 to 30%. respectively, providing substantial improvements in engine efficiency and specific power. Such performance improvements would significantly reduce engine emissions and the fuel logistics trails of armed forces. Progress towards a planned demonstration of a wave-rotor-topped Rolls-Royce Allison model 250 engine has included completion of the preliminary design and layout of the engine, the aerodynamic design of the wave rotor component and prediction of its aerodynamic performance characteristics in on- and off-design operation and during transients, and the aerodynamic design of transition ducts between the wave rotor and the high pressure turbine. The topping cycle increases the burner entry temperature and poses a design challenge to be met in the development of the demonstrator engine.

Modeling of transient heat pipe operation

NASA Technical Reports Server (NTRS)

Colwell, G. T.; Hartley, J. G.

1986-01-01

Mathematical models and associated solution procedures which can be used to design heat pipe cooled structures for use on hypersonic vehicles are being developed. The models should also have the capability to predict off-design performance for a variety of operating conditions. It is expected that the resulting models can be used to predict startup behavior of liquid metal heat pipes to be used in reentry vehicles, hypersonic aircraft, and space nuclear reactors. Work to date related to numerical solutions of governing differential equations for the outer shell and the combination capillary structure and working fluid is summarized. Finite element numerical equations using both implicit, explicit, and combination methods were examined.

Submillimetre wave imaging and security: imaging performance and prediction

NASA Astrophysics Data System (ADS)

Appleby, R.; Ferguson, S.

2016-10-01

Within the European Commission Seventh Framework Programme (FP7), CONSORTIS (Concealed Object Stand-Off Real-Time Imaging for Security) has designed and is fabricating a stand-off system operating at sub-millimetre wave frequencies for the detection of objects concealed on people. This system scans people as they walk by the sensor. This paper presents the top level system design which brings together both passive and active sensors to provide good performance. The passive system operates in two bands between 100 and 600GHz and is based on a cryogen free cooled focal plane array sensor whilst the active system is a solid-state 340GHz radar. A modified version of OpenFX was used for modelling the passive system. This model was recently modified to include realistic location-specific skin temperature and to accept animated characters wearing up to three layers of clothing that move dynamically, such as those typically found in cinematography. Targets under clothing have been modelled and the performance simulated. The strengths and weaknesses of this modelling approach are discussed.

Design and Performance Analysis of Depletion-Mode InSb Quantum-Well Field-Effect Transistor for Logic Applications

NASA Astrophysics Data System (ADS)

Islam, R.; Uddin, M. M.; Hossain, M. Mofazzal; Matin, M. A.

The design of a 1μm gate length depletion-mode InSb quantum-well field-effect transistor (QWFET) with a 10nm-thick Al2O3 gate dielectric has been optimized using a quantum corrected self-consistent Schrödinger-Poisson (QCSP) and two-dimensional drift-diffusion model. The model predicts a very high electron mobility of 4.42m2V-1s-1 at Vg=0V, a small pinch off gate voltage (Vp) of -0.25V, a maximum extrinsic transconductance (gm) of ˜4.85mS/μm and a drain current density of more than 3.34mA/μm. A short-circuit current-gain cut-off frequency (fT) of 374GHz and a maximum oscillation frequency (fmax) of 645GHz are predicted for the device. These characteristics make the device a potential candidate for low power, high-speed logic electronic device applications.

Performance back-deduction from a loading to flow coefficient map: Application to radial turbine

NASA Astrophysics Data System (ADS)

Carbonneau, Xavier; Binder, Nicolas

2012-12-01

Radial turbine stages are often used for applications requiring off-design operation, as turbocharging for instance. The off-design ability of such stages is commonly analyzed through the traditional turbine map, plotting the reduced mass-flow against the pressure-ratio, for reduced-speed lines. However, some alternatives are possible, such as the flow-coefficient ( Ψ) to loading-coefficient ( φ) diagram where the pressure-ratio lines are actually straight lines, very convenient property to perform prediction. A robust method re-creating this map from a predicted Ψ-φ diagram is needed. Recent work has shown that this back-deduction quality, without the use of any loss models, depends on the knowledge of an intermediate pressure-ratio. A modelization of this parameter is then proposed. The comparison with both experimental and CFD results is presented, with quite good agreement for mass flow rate and rotational speed, and for the intermediate pressure ratio. The last part of the paper is dedicated to the application of the intermediate pressure-ratio knowledge to the improvement of the deduction of the pressure ratio lines in the Ψ-φ diagram. Beside this improvement, the back-deduction method of the classical map is structured, applied and evaluated.

Cold flow testing of the Space Shuttle Main Engine high pressure fuel turbine model

NASA Technical Reports Server (NTRS)

Hudson, Susan T.; Gaddis, Stephen W.; Johnson, P. D.; Boynton, James L.

1991-01-01

In order to experimentally determine the performance of the Space Shuttle Main Engine (SSME) High Pressure Fuel Turbopump (HPFTP) turbine, a 'cold' air flow turbine test program was established at NASA's Marshall Space Flight Center. As part of this test program, a baseline test of Rocketdyne's HPFTP turbine has been completed. The turbine performance and turbine diagnostics such as airfoil surface static pressure distributions, static pressure drops through the turbine, and exit swirl angles were investigated at the turbine design point, over its operating range, and at extreme off-design points. The data was compared to pretest predictions with good results. The test data has been used to improve meanline prediction codes and is now being used to validate various three-dimensional codes. The data will also be scaled to engine conditions and used to improve the SSME steady-state performance model.

Off-Design Performance of Radial-Inflow Turbines

NASA Technical Reports Server (NTRS)

Meitner, P. L.; Glassman, A. J.

1986-01-01

Computer code determines rotor exit flow from hub to tip. RTOD (Radial Turbine Off-Design), computes off-design performance of radial turbine by modeling flow with stator viscous and trailing-edge losses, and with vaneless space loss between stator and rotor, and with rotor incidence, viscous, clearance, trailing-edge, and disk friction losses.

Design optimization of a prescribed vibration system using conjoint value analysis

NASA Astrophysics Data System (ADS)

Malinga, Bongani; Buckner, Gregory D.

2016-12-01

This article details a novel design optimization strategy for a prescribed vibration system (PVS) used to mechanically filter solids from fluids in oil and gas drilling operations. A dynamic model of the PVS is developed, and the effects of disturbance torques are detailed. This model is used to predict the effects of design parameters on system performance and efficiency, as quantified by system attributes. Conjoint value analysis, a statistical technique commonly used in marketing science, is utilized to incorporate designer preferences. This approach effectively quantifies and optimizes preference-based trade-offs in the design process. The effects of designer preferences on system performance and efficiency are simulated. This novel optimization strategy yields improvements in all system attributes across all simulated vibration profiles, and is applicable to other industrial electromechanical systems.

Identification of emergent off-nominal operational requirements during conceptual architecting of the more electric aircraft

NASA Astrophysics Data System (ADS)

Armstrong, Michael James

Increases in power demands and changes in the design practices of overall equipment manufacturers has led to a new paradigm in vehicle systems definition. The development of unique power systems architectures is of increasing importance to overall platform feasibility and must be pursued early in the aircraft design process. Many vehicle systems architecture trades must be conducted concurrent to platform definition. With an increased complexity introduced during conceptual design, accurate predictions of unit level sizing requirements must be made. Architecture specific emergent requirements must be identified which arise due to the complex integrated effect of unit behaviors. Off-nominal operating scenarios present sizing critical requirements to the aircraft vehicle systems. These requirements are architecture specific and emergent. Standard heuristically defined failure mitigation is sufficient for sizing traditional and evolutionary architectures. However, architecture concepts which vary significantly in terms of structure and composition require that unique failure mitigation strategies be defined for accurate estimations of unit level requirements. Identifying of these off-nominal emergent operational requirements require extensions to traditional safety and reliability tools and the systematic identification of optimal performance degradation strategies. Discrete operational constraints posed by traditional Functional Hazard Assessment (FHA) are replaced by continuous relationships between function loss and operational hazard. These relationships pose the objective function for hazard minimization. Load shedding optimization is performed for all statistically significant failures by varying the allocation of functional capability throughout the vehicle systems architecture. Expressing hazards, and thereby, reliability requirements as continuous relationships with the magnitude and duration of functional failure requires augmentations to the traditional means for system safety assessment (SSA). The traditional two state and discrete system reliability assessment proves insufficient. Reliability is, therefore, handled in an analog fashion: as a function of magnitude of failure and failure duration. A series of metrics are introduced which characterize system performance in terms of analog hazard probabilities. These include analog and cumulative system and functional risk, hazard correlation, and extensions to the traditional component importance metrics. Continuous FHA, load shedding optimization, and analog SSA constitute the SONOMA process (Systematic Off-Nominal Requirements Analysis). Analog system safety metrics inform both architecture optimization (changes in unit level capability and reliability) and architecture augmentation (changes in architecture structure and composition). This process was applied for two vehicle systems concepts (conventional and 'more-electric') in terms of loss/hazard relationships with varying degrees of fidelity. Application of this process shows that the traditional assumptions regarding the structure of the function loss vs. hazard relationship apply undue design bias to functions and components during exploratory design. This bias is illustrated in terms of inaccurate estimations of the system and function level risk and unit level importance. It was also shown that off-nominal emergent requirements must be defined specific to each architecture concept. Quantitative comparisons of architecture specific off-nominal performance were obtained which provide evidence to the need for accurate definition of load shedding strategies during architecture exploratory design. Formally expressing performance degradation strategies in terms of the minimization of a continuous hazard space enhances the system architects ability to accurately predict sizing critical emergent requirements concurrent to architecture definition. Furthermore, the methods and frameworks generated here provide a structured and flexible means for eliciting these architecture specific requirements during the performance of architecture trades.

Design and implementation of the flight dynamics system for COMS satellite mission operations

NASA Astrophysics Data System (ADS)

Lee, Byoung-Sun; Hwang, Yoola; Kim, Hae-Yeon; Kim, Jaehoon

2011-04-01

The first Korean multi-mission geostationary Earth orbit satellite, Communications, Ocean, and Meteorological Satellite (COMS) was launched by an Ariane 5 launch vehicle in June 26, 2010. The COMS satellite has three payloads including Ka-band communications, Geostationary Ocean Color Imager, and Meteorological Imager. Although the COMS spacecraft bus is based on the Astrium Eurostar 3000 series, it has only one solar array to the south panel because all of the imaging sensors are located on the north panel. In order to maintain the spacecraft attitude with 5 wheels and 7 thrusters, COMS should perform twice a day wheel off-loading thruster firing operations, which affect on the satellite orbit. COMS flight dynamics system provides the general on-station functions such as orbit determination, orbit prediction, event prediction, station-keeping maneuver planning, station-relocation maneuver planning, and fuel accounting. All orbit related functions in flight dynamics system consider the orbital perturbations due to wheel off-loading operations. There are some specific flight dynamics functions to operate the spacecraft bus such as wheel off-loading management, oscillator updating management, and on-station attitude reacquisition management. In this paper, the design and implementation of the COMS flight dynamics system is presented. An object oriented analysis and design methodology is applied to the flight dynamics system design. Programming language C# within Microsoft .NET framework is used for the implementation of COMS flight dynamics system on Windows based personal computer.

Wave rotor demonstrator engine assessment

NASA Technical Reports Server (NTRS)

Snyder, Philip H.

1996-01-01

The objective of the program was to determine a wave rotor demonstrator engine concept using the Allison 250 series engine. The results of the NASA LERC wave rotor effort were used as a basis for the wave rotor design. A wave rotor topped gas turbine engine was identified which incorporates five basic requirements of a successful demonstrator engine. Predicted performance maps of the wave rotor cycle were used along with maps of existing gas turbine hardware in a design point study. The effects of wave rotor topping on the engine cycle and the subsequent need to rematch compressor and turbine sections in the topped engine were addressed. Comparison of performance of the resulting engine is made on the basis of wave rotor topped engine versus an appropriate baseline engine using common shaft compressor hardware. The topped engine design clearly demonstrates an impressive improvement in shaft horsepower (+11.4%) and SFC (-22%). Off design part power engine performance for the wave rotor topped engine was similarly improved including that at engine idle conditions. Operation of the engine at off design was closely examined with wave rotor operation at less than design burner outlet temperatures and rotor speeds. Challenges identified in the development of a demonstrator engine are discussed. A preliminary design was made of the demonstrator engine including wave rotor to engine transition ducts. Program cost and schedule for a wave rotor demonstrator engine fabrication and test program were developed.

On-off nonlinear active control of floor vibrations

NASA Astrophysics Data System (ADS)

Díaz, Iván M.; Reynolds, Paul

2010-08-01

Human-induced floor vibrations can be mitigated by means of active control via an electromagnetic proof-mass actuator. Previous researchers have developed a system for floor vibration comprising linear velocity feedback control (LVFC) with a command limiter (saturation in the command signal to avoid actuator overloading). The performance of this control is highly dependent on the linear gain utilised, which has to be designed for a particular excitation and might not be optimum for other excitations. This work explores the use of on-off nonlinear velocity feedback control (NLVFC) as the natural evolution of LVFC when high gains and/or significant vibration level are present together with saturation in the control law. Firstly, the describing function tool is employed to analyse the stability properties of: (1) LVFC with saturation, (2) on-off NLVFC with a dead zone and (3) on-off NLVFC with a switching-off function. Particular emphasis is paid to the resulting limit cycle behaviour and the design of appropriate dead zone and switching-off levels to avoid it. Secondly, experimental trials using the three control laws are conducted on a laboratory test floor. The results corroborate the analytical stability predictions. The pros of on-off NLVFC are that no gain has to be chosen and maximum actuator energy is delivered to cancel the vibration. In contrast, the requirement to select a dead zone or switching-off function provides a drawback in its application.

Flow in a centrifugal fan impeller at off-design conditions

NASA Astrophysics Data System (ADS)

Wright, T.; Tzou, K. T. S.; Madhavan, S.

1984-06-01

A fully three-dimensional finite element analysis of inviscid, incompressible blade channel flow is the basis of the present study of both predicted and measured surface velocity and pressure distributions in the internal flow channels of a centrifugal fan impeller, for volume flow rates of 80-125 percent the design flow rate. The experimental results made extensive use of blade and sidewall surface pressure taps installed in a scale model of an airfoil-bladed centrifugal fan impeller. The results obtained illustrate the ability of both flow analyses to predict the dominant features of the impeller flow field, including peak blade surface velocities and adverse gradients at flows far from the design point. Insight is also gained into the limiting channel diffusion values for typical centrifugal cascade performance, together with the influence of viscous effects, as seen in deviations from ideal flow predictions.

Performance (Off-Design) Cycle Analysis for a Turbofan Engine With Interstage Turbine Burner

NASA Technical Reports Server (NTRS)

Liew, K. H.; Urip, E.; Yang, S. L.; Mattingly, J. D.; Marek, C. J.

2005-01-01

This report presents the performance of a steady-state, dual-spool, separate-exhaust turbofan engine, with an interstage turbine burner (ITB) serving as a secondary combustor. The ITB, which is located in the transition duct between the high- and the low-pressure turbines, is a relatively new concept for increasing specific thrust and lowering pollutant emissions in modern jet-engine propulsion. A detailed off-design performance analysis of ITB engines is written in Microsoft(Registered Trademark) Excel (Redmond, Washington) macrocode with Visual Basic Application to calculate engine performances over the entire operating envelope. Several design-point engine cases are pre-selected using a parametric cycle-analysis code developed previously in Microsoft(Registered Trademark) Excel, for off-design analysis. The off-design code calculates engine performances (i.e. thrust and thrust-specific-fuel-consumption) at various flight conditions and throttle settings.

Design of a miniature wind turbine for powering wireless sensors

NASA Astrophysics Data System (ADS)

Xu, F. J.; Yuan, F. G.; Hu, J. Z.; Qiu, Y. P.

2010-04-01

In this paper, a miniature wind turbine (MWT) system composed of commercially available off-the-shelf components was designed and tested for harvesting energy from ambient airflow to power wireless sensors. To make MWT operate at very low air flow rates, a 7.6 cm thorgren plastic Propeller blade was adopted as the wind turbine blade. A sub watt brushless DC motor was used as generator. To predict the performance of the MWT, an equivalent circuit model was employed for analyzing the output power and the net efficiency of the MWT system. In theory, the maximum net efficiency 14.8% of the MWT system was predicted. Experimental output power of the MWT versus resistive loads ranging from 5 ohms to 500 ohms under wind speeds from 3 m/s to 4.5 m/s correlates well with those from the predicted model, which means that the equivalent circuit model provides a guideline for optimizing the performance of the MWT and can be used for fulfilling the design requirements by selecting specific components for powering wireless sensors.

Design and testing of focusing magnets for a compact electron linac

NASA Astrophysics Data System (ADS)

Chen, Qushan; Qin, Bin; Liu, Kaifeng; Liu, Xu; Fu, Qiang; Tan, Ping; Hu, Tongning; Pei, Yuanji

2015-10-01

Solenoid field errors have great influence on electron beam qualities. In this paper, design and testing of high precision solenoids for a compact electron linac is presented. We proposed an efficient and practical method to solve the peak field of the solenoid for relativistic electron beams based on the reduced envelope equation. Beam dynamics involving space charge force were performed to predict the focusing effects. Detailed optimization methods were introduced to achieve an ultra-compact configuration as well as high accuracy, with the help of the POISSON and OPERA packages. Efforts were attempted to restrain system errors in the off-line testing, which showed the short lens and the main solenoid produced a peak field of 0.13 T and 0.21 T respectively. Data analysis involving central and off axes was carried out and demonstrated that the testing results fitted well with the design.

Space station definitions, design, and development. Task 5: Multiple arm telerobot coordination and control: Manipulator design methodology

NASA Technical Reports Server (NTRS)

Stoughton, R. M.

1990-01-01

A proposed methodology applicable to the design of manipulator systems is described. The current design process is especially weak in the preliminary design phase, since there is no accepted measure to be used in trading off different options available for the various subsystems. The design process described uses Cartesian End-Effector Impedance as a measure of performance for the system. Having this measure of performance, it is shown how it may be used to determine the trade-offs necessary to the preliminary design phase. The design process involves three main parts: (1) determination of desired system performance in terms of End-Effector Impedance; (2) trade-off design options to achieve this desired performance; and (3) verification of system performance through laboratory testing. The design process is developed using numerous examples and experiments to demonstrate the feasability of this approach to manipulator design.

Pathological tremor prediction using surface EMG and acceleration: potential use in “ON-OFF” demand driven deep brain stimulator design

PubMed Central

Basu, Ishita; Graupe, Daniel; Tuninetti, Daniela; Shukla, Pitamber; Slavin, Konstantin V.; Metman, Leo Verhagen; Corcos, Daniel M.

2013-01-01

Objective We present a proof of concept for a novel method of predicting the onset of pathological tremor using non-invasively measured surface electromyogram (sEMG) and acceleration from tremor-affected extremities of patients with Parkinson’s disease (PD) and Essential tremor (ET). Approach The tremor prediction algorithm uses a set of spectral (fourier and wavelet) and non-linear time series (entropy and recurrence rate) parameters extracted from the non-invasively recorded sEMG and acceleration signals. Main results The resulting algorithm is shown to successfully predict tremor onset for all 91 trials recorded in 4 PD patients and for all 91 trials recorded in 4 ET patients. The predictor achieves a 100% sensitivity for all trials considered, along with an overall accuracy of 85.7% for all ET trials and 80.2% for all PD trials. By using a Pearson’s chi-square test, the prediction results are shown to significantly differ from a random prediction outcome. Significance The tremor prediction algorithm can be potentially used for designing the next generation of non-invasive closed-loop predictive ON-OFF controllers for deep brain stimulation (DBS), used for suppressing pathological tremor in such patients. Such a system is based on alternating ON and OFF DBS periods, an incoming tremor being predicted during the time intervals when DBS is OFF, so as to turn DBS back ON. The prediction should be a few seconds before tremor re-appears so that the patient is tremor-free for the entire DBS ON-OFF cycle as well as the tremor-free DBS OFF interval should be maximized in order to minimize the current injected in the brain and battery usage. PMID:23658233

Pathological tremor prediction using surface electromyogram and acceleration: potential use in ‘ON-OFF’ demand driven deep brain stimulator design

NASA Astrophysics Data System (ADS)

Basu, Ishita; Graupe, Daniel; Tuninetti, Daniela; Shukla, Pitamber; Slavin, Konstantin V.; Verhagen Metman, Leo; Corcos, Daniel M.

2013-06-01

Objective. We present a proof of concept for a novel method of predicting the onset of pathological tremor using non-invasively measured surface electromyogram (sEMG) and acceleration from tremor-affected extremities of patients with Parkinson’s disease (PD) and essential tremor (ET). Approach. The tremor prediction algorithm uses a set of spectral (Fourier and wavelet) and nonlinear time series (entropy and recurrence rate) parameters extracted from the non-invasively recorded sEMG and acceleration signals. Main results. The resulting algorithm is shown to successfully predict tremor onset for all 91 trials recorded in 4 PD patients and for all 91 trials recorded in 4 ET patients. The predictor achieves a 100% sensitivity for all trials considered, along with an overall accuracy of 85.7% for all ET trials and 80.2% for all PD trials. By using a Pearson’s chi-square test, the prediction results are shown to significantly differ from a random prediction outcome. Significance. The tremor prediction algorithm can be potentially used for designing the next generation of non-invasive closed-loop predictive ON-OFF controllers for deep brain stimulation (DBS), used for suppressing pathological tremor in such patients. Such a system is based on alternating ON and OFF DBS periods, an incoming tremor being predicted during the time intervals when DBS is OFF, so as to turn DBS back ON. The prediction should be a few seconds before tremor re-appears so that the patient is tremor-free for the entire DBS ON-OFF cycle and the tremor-free DBS OFF interval should be maximized in order to minimize the current injected in the brain and battery usage.

Application of active controls technology to aircraft bide smoothing systems

NASA Technical Reports Server (NTRS)

Lapins, M.; Jacobson, I. D.

1975-01-01

A critical review of past efforts in the design and testing of ride smoothing and gust alleviation systems is presented. Design trade offs involving sensor types, choice of feedback loops, human comfort, and aircraft handling-qualities criteria are discussed. Synthesis of a system designed to employ direct-lift and side-force producing surfaces is reported. Two STOL aircraft and an executive transport are considered. Theoretically predicted system performance is compared with hybrid simulation and flight test data. Pilot opinion rating, pilot workload, and passenger comfort rating data for the basic and augmented aircraft are included.

Application of Active Controls Technology to Aircraft Ride Smoothing Systems

NASA Technical Reports Server (NTRS)

Lapins, Maris; Jacobson, Ira D.

1975-01-01

A critical review of past efforts in the design and testing of ride smoothing and gust alleviation systems is presented. Design trade-offs involving sensor types, choice of feedback loops, human comfort and aircraft handling-qualities criteria are discussed. Synthesis of a system designed to employ direct-lift and side-force producing surfaces is reported. Two STOL-class aircraft and an executive transport are considered. Theoretically-predicted system performance is compared with hybrid simulation and flight test data. Pilot opinion rating, pilot workload, and passenger comfort rating data for the basic and augmented aircraft are included.

Performance Evaluation of a High Bandwidth Liquid Fuel Modulation Valve for Active Combustion Control

NASA Technical Reports Server (NTRS)

Saus, Joseph R.; DeLaat, John C.; Chang, Clarence T.; Vrnak, Daniel R.

2012-01-01

At the NASA Glenn Research Center, a characterization rig was designed and constructed for the purpose of evaluating high bandwidth liquid fuel modulation devices to determine their suitability for active combustion control research. Incorporated into the rig s design are features that approximate conditions similar to those that would be encountered by a candidate device if it were installed on an actual combustion research rig. The characterized dynamic performance measures obtained through testing in the rig are planned to be accurate indicators of expected performance in an actual combustion testing environment. To evaluate how well the characterization rig predicts fuel modulator dynamic performance, characterization rig data was compared with performance data for a fuel modulator candidate when the candidate was in operation during combustion testing. Specifically, the nominal and off-nominal performance data for a magnetostrictive-actuated proportional fuel modulation valve is described. Valve performance data were collected with the characterization rig configured to emulate two different combustion rig fuel feed systems. Fuel mass flows and pressures, fuel feed line lengths, and fuel injector orifice size was approximated in the characterization rig. Valve performance data were also collected with the valve modulating the fuel into the two combustor rigs. Comparison of the predicted and actual valve performance data show that when the valve is operated near its design condition the characterization rig can appropriately predict the installed performance of the valve. Improvements to the characterization rig and accompanying modeling activities are underway to more accurately predict performance, especially for the devices under development to modulate fuel into the much smaller fuel injectors anticipated in future lean-burning low-emissions aircraft engine combustors.

Does probability guided hysteroscopy reduce costs in women investigated for postmenopausal bleeding?

PubMed

Breijer, M C; van Hanegem, N; Visser, N C M; Verheijen, R H M; Mol, B W J; Pijnenborg, J M A; Opmeer, B C; Timmermans, A

2015-01-01

To evaluate whether a model to predict a failed endometrial biopsy in women with postmenopausal bleeding (PMB) and a thickened endometrium can reduce costs without compromising diagnostic accuracy. Model based cost-minimization analysis. A decision analytic model was designed to compare two diagnostic strategies for women with PMB: (I) attempting office endometrial biopsy and performing outpatient hysteroscopy after failed biopsy and (II) predicted probability of a failed endometrial biopsy based on patient characteristics to guide the decision for endometrial biopsy or immediate hysteroscopy. Robustness of assumptions regarding costs was evaluated in sensitivity analyses. Costs for the different strategies. At different cut-offs for the predicted probability of failure of an endometrial biopsy, strategy I was generally less expensive than strategy II. The costs for strategy I were always € 460; the costs for strategy II varied between € 457 and € 475. At a 65% cut-off, a possible saving of € 3 per woman could be achieved. Individualizing the decision to perform an endometrial biopsy or immediate hysteroscopy in women presenting with postmenopausal bleeding based on patient characteristics does not increase the efficiency of the diagnostic work-up.

New Stagnation Arc Jet Model Design for Testing ADEPT 3-D Carbon Cloth

NASA Technical Reports Server (NTRS)

Beck, R.; Chen, Y.-K.; Wercinski, P.; Agrawal, P.; Chavez-Garcia, J.

2017-01-01

The ADEPT concept has been considered as an entry, descent and landing system to enable Human Mars class missions. Ground rules for the Mars studies required aerocapture, orbit, and then entry. The design utilizes a 3-D woven carbon cloth fabric as both heatshield and primary structure and design guidelines required 6 layers remaining after all entry events. The peak heating predicted for the ADEPT carbon cloth was 35 Wcm2 and resulting temperatures were predicted to be 1400K. Predictions for carbon mass loss were performed using equilibrium thermochemistry, which is only accurate for T2000K. Carbon oxidation is kinetically controlled at T2000K, and mass loss drops off considerably from equilibrium values. Design of the cloth thickness and mass would be significantly reduced if kinetics were considered. This effort was to design a stagnation test article design that could be used in the AHF with varying levels of oxygen where the results could be used to develop an engineering model to describe the recession rate of the carbon as a function of the partial pressure of monotomic oxygen.

Prediction of multi performance characteristics of wire EDM process using grey ANFIS

NASA Astrophysics Data System (ADS)

Kumanan, Somasundaram; Nair, Anish

2017-09-01

Super alloys are used to fabricate components in ultra-supercritical power plants. These hard to machine materials are processed using non-traditional machining methods like Wire cut electrical discharge machining and needs attention. This paper details about multi performance optimization of wire EDM process using Grey ANFIS. Experiments are designed to establish the performance characteristics of wire EDM such as surface roughness, material removal rate, wire wear rate and geometric tolerances. The control parameters are pulse on time, pulse off time, current, voltage, flushing pressure, wire tension, table feed and wire speed. Grey relational analysis is employed to optimise the multi objectives. Analysis of variance of the grey grades is used to identify the critical parameters. A regression model is developed and used to generate datasets for the training of proposed adaptive neuro fuzzy inference system. The developed prediction model is tested for its prediction ability.

Spatial Resolution, Grayscale, and Error Diffusion Trade-offs: Impact on Display System Design

NASA Technical Reports Server (NTRS)

Gille, Jennifer L. (Principal Investigator)

1996-01-01

We examine technology trade-offs related to grayscale resolution, spatial resolution, and error diffusion for tessellated display systems. We present new empirical results from our psychophysical study of these trade-offs and compare them to the predictions of a model of human vision.

Spiders in motion: demonstrating adaptation, structure-function relationships, and trade-offs in invertebrates.

PubMed

Bowlin, Melissa S; McLeer, Dorothy F; Danielson-Francois, Anne M

2014-03-01

Evolutionary history and structural considerations constrain all aspects of animal physiology. Constraints on invertebrate locomotion are especially straightforward for students to observe and understand. In this exercise, students use spiders to investigate the concepts of adaptation, structure-function relationships, and trade-offs. Students measure burst and endurance performance in several taxonomic families of spiders whose ecological niches have led to different locomotory adaptations. Based on observations of spiders in their natural habitat and prior background information, students make predictions about spider performance. Students then construct their own knowledge by performing a hands-on, inquiry-based scientific experiment where the results are not necessarily known. Depending on the specific families chosen, students can observe that web-dwelling spiders have more difficulty navigating complex terrestrial terrain than ground-dwelling spiders and that there is a trade-off between burst performance and endurance performance in spiders. Our inexpensive runway design allows for countless variations on this basic experiment; for example, we have successfully used runways to show students how the performance of heterothermic ectotherms varies with temperature. High levels of intra- and interindividual variation in performance underscore the importance of using multiple trials and statistical tests. Finally, this laboratory activity can be completely student driven or standardized, depending on the instructor's preference.

Aircraft Conceptual Design and Risk Analysis Using Physics-Based Noise Prediction

NASA Technical Reports Server (NTRS)

Olson, Erik D.; Mavris, Dimitri N.

2006-01-01

An approach was developed which allows for design studies of commercial aircraft using physics-based noise analysis methods while retaining the ability to perform the rapid trade-off and risk analysis studies needed at the conceptual design stage. A prototype integrated analysis process was created for computing the total aircraft EPNL at the Federal Aviation Regulations Part 36 certification measurement locations using physics-based methods for fan rotor-stator interaction tones and jet mixing noise. The methodology was then used in combination with design of experiments to create response surface equations (RSEs) for the engine and aircraft performance metrics, geometric constraints and take-off and landing noise levels. In addition, Monte Carlo analysis was used to assess the expected variability of the metrics under the influence of uncertainty, and to determine how the variability is affected by the choice of engine cycle. Finally, the RSEs were used to conduct a series of proof-of-concept conceptual-level design studies demonstrating the utility of the approach. The study found that a key advantage to using physics-based analysis during conceptual design lies in the ability to assess the benefits of new technologies as a function of the design to which they are applied. The greatest difficulty in implementing physics-based analysis proved to be the generation of design geometry at a sufficient level of detail for high-fidelity analysis.

Study of design constraints on helicopter noise

NASA Technical Reports Server (NTRS)

Sternfeld, H., Jr.; Wiedersum, C. W.

1979-01-01

A means of estimating the noise generated by a helicopter main rotor using information which is generally available during the preliminary design phase of aircraft development is presented. The method utilizes design charts and tables which do not require an understanding of acoustical theory or computational procedures in order to predict the perceived noise level, a weighted sound pressure level, or C weighted sound pressure level of a single hovering rotor. A method for estimating the effective perceived noise level in forward flight is also included. In order to give the designer an assessment of the relative rotor performance, which may be traded off against noise, an additional chart for estimating the percent of available rotor thrust which must be expended in lifting the rotor and drive system, is included as well as approach for comparing the subjective acceptability of various rotors once the absolute sound pressure levels are predicted.

Spanwise morphing trailing edge on a finite wing

NASA Astrophysics Data System (ADS)

Pankonien, Alexander M.; Inman, Daniel J.

2015-04-01

Unmanned Aerial Vehicles are prime targets for morphing implementation as they must adapt to large changes in flight conditions associated with locally varying wind or large changes in mass associated with payload delivery. The Spanwise Morphing Trailing Edge concept locally varies the trailing edge camber of a wing or control surface, functioning as a modular replacement for conventional ailerons without altering the spar box. Utilizing alternating active sections of Macro Fiber Composites (MFCs) driving internal compliant mechanisms and inactive sections of elastomeric honeycombs, the SMTE concept eliminates geometric discontinuities associated with shape change, increasing aerodynamic performance. Previous work investigated a representative section of the SMTE concept and investigated the effect of various skin designs on actuation authority. The current work experimentally evaluates the aerodynamic gains for the SMTE concept for a representative finite wing as compared with a conventional, articulated wing. The comparative performance for both wings is evaluated by measuring the drag penalty associated with achieving a design lift coefficient from an off-design angle of attack. To reduce experimental complexity, optimal control configurations are predicted with lifting line theory and experimentally measured control derivatives. Evaluated over a range of off-design flight conditions, this metric captures the comparative capability of both concepts to adapt or "morph" to changes in flight conditions. Even with this simplistic model, the SMTE concept is shown to reduce the drag penalty due to adaptation up to 20% at off-design conditions, justifying the increase in mass and complexity and motivating concepts capable of larger displacement ranges, higher fidelity modelling, and condition-sensing control.

A Passive Cavity Concept for Improving the Off-Design Performance of Fixed-Geometry Exhaust Nozzles

NASA Technical Reports Server (NTRS)

Asbury, Scott C.; Gunther, Christopher L.; Hunter, Craig A.

1996-01-01

An investigation was conducted in the model preparation area of the Langley 16-Foot Transonic Tunnel to study a passive cavity concept for improving the off-design performance of fixed-geometry exhaust nozzles. Passive cavity ventilation (through a porous surface) was applied to divergent flap surfaces and tested at static conditions in a sub-scale, nonaxisymmetric, convergent-divergent nozzle. As part of a comprehensive investigation, force, moment and pressure measurements were taken and focusing schlieren flow visualization was obtained for a baseline configuration and D passive cavity configurations. All tests were conducted with no external flow and high-pressure air was used to simulate jet-exhaust flow at nozzle pressure ratios from 1.25 to approximately 9.50. Results indicate that baseline nozzle performance was dominated by unstable shock-induced boundary-layer separation at off-design conditions, which came about through the natural tendency of overexpanded exhaust flow to satisfy conservation requirements by detaching from the nozzle divergent flaps. Passive cavity ventilation added the ability to control off-design separation in the nozzle by either alleviating separation or encouraging stable separation of the exhaust flow. Separation alleviation offers potential for installed nozzle performance benefits by reducing drag at forward flight speeds, even though it may reduce off-design static thrust efficiency as much as 3.2 percent. Encouraging stable separation of the exhaust flow offers significant performance improvements at static, low NPR and low Mach number flight conditions by improving off-design static thrust efficiency as much as 2.8 percent. By designing a fixed-geometry nozzle with fully porous divergent flaps, where both cavity location and percent open porosity of the flaps could be varied, passive flow control would make it possible to improve off-design nozzle performance across a wide operating range. In addition, the ability to encourage separation on one flap while alleviating it on the other makes it possible to generate thrust vectoring in the nozzle through passive flow control.

Multiple Off-Ice Performance Variables Predict On-Ice Skating Performance in Male and Female Division III Ice Hockey Players.

PubMed

Janot, Jeffrey M; Beltz, Nicholas M; Dalleck, Lance D

2015-09-01

The purpose of this study was to determine if off-ice performance variables could predict on-ice skating performance in Division III collegiate hockey players. Both men (n = 15) and women (n = 11) hockey players (age = 20.5 ± 1.4 years) participated in the study. The skating tests were agility cornering S-turn, 6.10 m acceleration, 44.80 m speed, modified repeat skate, and 15.20 m full speed. Off-ice variables assessed were years of playing experience, height, weight and percent body fat and off-ice performance variables included vertical jump (VJ), 40-yd dash (36.58m), 1-RM squat, pro-agility, Wingate peak power and peak power percentage drop (% drop), and 1.5 mile (2.4km) run. Results indicated that 40-yd dash (36.58m), VJ, 1.5 mile (2.4km) run, and % drop were significant predictors of skating performance for repeat skate (slowest, fastest, and average time) and 44.80 m speed time, respectively. Four predictive equations were derived from multiple regression analyses: 1) slowest repeat skate time = 2.362 + (1.68 x 40-yd dash time) + (0.005 x 1.5 mile run), 2) fastest repeat skate time = 9.762 - (0.089 x VJ) - (0.998 x 40-yd dash time), 3) average repeat skate time = 7.770 + (1.041 x 40-yd dash time) - (0.63 x VJ) + (0.003 x 1.5 mile time), and 4) 47.85 m speed test = 7.707 - (0.050 x VJ) - (0.01 x % drop). It was concluded that selected off-ice tests could be used to predict on-ice performance regarding speed and recovery ability in Division III male and female hockey players. Key pointsThe 40-yd dash (36.58m) and vertical jump tests are significant predictors of on-ice skating performance specific to speed.In addition to 40-yd dash and vertical jump, the 1.5 mile (2.4km) run for time and percent power drop from the Wingate anaerobic power test were also significant predictors of skating performance that incorporates the aspect of recovery from skating activity.Due to the specificity of selected off-ice variables as predictors of on-ice performance, coaches can elect to assess player performance off-ice and focus on other uses of valuable ice time for their individual teams.

Numerical and In Vitro Experimental Investigation of the Hemolytic Performance at the Off-Design Point of an Axial Ventricular Assist Pump.

PubMed

Liu, Guang-Mao; Jin, Dong-Hai; Jiang, Xi-Hang; Zhou, Jian-Ye; Zhang, Yan; Chen, Hai-Bo; Hu, Sheng-Shou; Gui, Xing-Min

The ventricular assist pumps do not always function at the design point; instead, these pumps may operate at unfavorable off-design points. For example, the axial ventricular assist pump FW-2, in which the design point is 5 L/min flow rate against 100 mm Hg pressure increase at 8,000 rpm, sometimes works at off-design flow rates of 1 to 4 L/min. The hemolytic performance of the FW-2 at both the design point and at off-design points was estimated numerically and tested in vitro. Flow characteristics in the pump were numerically simulated and analyzed with special attention paid to the scalar sheer stress and exposure time. An in vitro hemolysis test was conducted to verify the numerical results. The simulation results showed that the scalar shear stress in the rotor region at the 1 L/min off-design point was 70% greater than at the 5 L/min design point. The hemolysis index at the 1 L/min off-design point was 3.6 times greater than at the 5 L/min design point. The in vitro results showed that the normalized index of hemolysis increased from 0.017 g/100 L at the 5 L/min design point to 0.162 g/100 L at the 1 L/min off-design point. The hemolysis comparison between the different blood pump flow rates will be helpful for future pump design point selection and will guide the usage of ventricular assist pumps. The hemolytic performance of the blood pump at the working point in the clinic should receive more focus.

A Numerical Analysis on the Effects of Self-Excited Tip Flow Unsteadiness and Upstream Blade Row Interactions on the Performance Predictions of a Transonic Compressor

NASA Astrophysics Data System (ADS)

Heberling, Brian

Computational fluid dynamics (CFD) simulations can offer a detailed view of the complex flow fields within an axial compressor and greatly aid the design process. However, the desire for quick turnaround times raises the question of how exact the model must be. At design conditions, steady CFD simulating an isolated blade row can accurately predict the performance of a rotor. However, as a compressor is throttled and mass flow rate decreased, axial flow becomes weaker making the capturing of unsteadiness, wakes, or other flow features more important. The unsteadiness of the tip clearance flow and upstream blade wake can have a significant impact on a rotor. At off-design conditions, time-accurate simulations or modeling multiple blade rows can become necessary in order to receive accurate performance predictions. Unsteady and multi- bladerow simulations are computationally expensive, especially when used in conjunction. It is important to understand which features are important to model in order to accurately capture a compressor's performance. CFD simulations of a transonic axial compressor throttling from the design point to stall are presented. The importance of capturing the unsteadiness of the rotor tip clearance flow versus capturing upstream blade-row interactions is examined through steady and unsteady, single- and multi-bladerow computations. It is shown that there are significant differences at near stall conditions between the different types of simulations.

How merging droplets jump off a superhydrophobic surface: Measurements and model

NASA Astrophysics Data System (ADS)

Mouterde, Timothée; Nguyen, Thanh-Vinh; Takahashi, Hidetoshi; Clanet, Christophe; Shimoyama, Isao; Quéré, David

2017-11-01

We investigate how drops merging on a nonwettable surface jump off this surface, for both symmetric and asymmetric coalescences. For this purpose, we design and build a microelectromechanical system sensor able to quantify forces down to the micro-Newton scale at a high acquisition rate (200 kHz). Using this device, we perform direct force measurements of self-propelled droplets coupled to high-speed imaging. Experimental data show that the total momentum of the drop after coalescence mainly depends on the size of the smaller drop. Exploiting this finding, we quantitatively predict the takeoff speed of jumping drop pairs and show how to correct the usual argument based on energy conservation.

Slow but tenacious: an analysis of running and gripping performance in chameleons.

PubMed

Herrel, Anthony; Tolley, Krystal A; Measey, G John; da Silva, Jessica M; Potgieter, Daniel F; Boller, Elodie; Boistel, Renaud; Vanhooydonck, Bieke

2013-03-15

Chameleons are highly specialized and mostly arboreal lizards characterized by a suite of derived characters. The grasping feet and tail are thought to be related to the arboreal lifestyle of chameleons, yet specializations for grasping are thought to exhibit a trade-off with running ability. Indeed, previous studies have demonstrated a trade-off between running and clinging performance, with faster species being poorer clingers. Here we investigate the presence of trade-offs by measuring running and grasping performance in four species of chameleon belonging to two different clades (Chamaeleo and Bradypodion). Within each clade we selected a largely terrestrial species and a more arboreal species to test whether morphology and performance are related to habitat use. Our results show that habitat drives the evolution of morphology and performance but that some of these effects are specific to each clade. Terrestrial species in both clades show poorer grasping performance than more arboreal species and have smaller hands. Moreover, hand size best predicts gripping performance, suggesting that habitat use drives the evolution of hand morphology through its effects on performance. Arboreal species also had longer tails and better tail gripping performance. No differences in sprint speed were observed between the two Chamaeleo species. Within Bradypodion, differences in sprint speed were significant after correcting for body size, yet the arboreal species were both better sprinters and had greater clinging strength. These results suggest that previously documented trade-offs may have been caused by differences between clades (i.e. a phylogenetic effect) rather than by design conflicts between running and gripping per se.

Design of a thermosyphon-based thermal valve for controlled high-temperature heat extraction

DOE PAGES

Oshman, Christopher; Hardin, Corey; Rea, Jonathan; ...

2017-01-16

Conventional concentrated solar power (CSP) is a reliable alternative energy source that uses the sun’s heat to drive a heat engine to produce electrical power. An advantage of CSP is its ability to store thermal energy for use during off-sun hours which is typically done by storing sensible heat in molten salts. Alternatively, thermal energy may be stored as latent heat in a phase-change material (PCM), which stores large quantities of thermal energy in an isothermal process. On-sun, the PCM melts, storing energy. Off-sun, the latent heat is extracted to produce dispatchable electrical power. Here, this paper presents the designmore » of a thermosyphon-based device with sodium working fluid that is able to extract heat from a source as demand requires. A prototype has been designed to transfer 37 kW of thermal energy from a 600°C molten PCM tank to an array of 9% efficient thermoelectric generators (TEGs) to produce 3 kW of usable electrical energy for 5 h. This “thermal valve” design incorporates a funnel to collect condensate and a central shut-off valve to control condensate gravity return to the evaporator. Three circumferential tubes allow vapour transport up to the condenser. Pressure and a thermal resistance models were developed to predict the performance of the thermal valve. The pressure model predicts that the thermal valve will function as designed. The thermal resistance model predicts a 5500× difference in total thermal resistance between “on” and “off” states. The evaporator and condenser walls comprise 96% of the “on” thermal resistance, while the small parasitic heat transfer in the “off” state is primarily (77%) due to radiation losses. Lastly, this simple and effective technology can have a strong impact on the feasibility, scalability, and dispatchability of CSP latent storage. In addition, other industrial and commercial applications can benefit from this thermal valve concept.« less

Design of a thermosyphon-based thermal valve for controlled high-temperature heat extraction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oshman, Christopher; Hardin, Corey; Rea, Jonathan

Conventional concentrated solar power (CSP) is a reliable alternative energy source that uses the sun’s heat to drive a heat engine to produce electrical power. An advantage of CSP is its ability to store thermal energy for use during off-sun hours which is typically done by storing sensible heat in molten salts. Alternatively, thermal energy may be stored as latent heat in a phase-change material (PCM), which stores large quantities of thermal energy in an isothermal process. On-sun, the PCM melts, storing energy. Off-sun, the latent heat is extracted to produce dispatchable electrical power. Here, this paper presents the designmore » of a thermosyphon-based device with sodium working fluid that is able to extract heat from a source as demand requires. A prototype has been designed to transfer 37 kW of thermal energy from a 600°C molten PCM tank to an array of 9% efficient thermoelectric generators (TEGs) to produce 3 kW of usable electrical energy for 5 h. This “thermal valve” design incorporates a funnel to collect condensate and a central shut-off valve to control condensate gravity return to the evaporator. Three circumferential tubes allow vapour transport up to the condenser. Pressure and a thermal resistance models were developed to predict the performance of the thermal valve. The pressure model predicts that the thermal valve will function as designed. The thermal resistance model predicts a 5500× difference in total thermal resistance between “on” and “off” states. The evaporator and condenser walls comprise 96% of the “on” thermal resistance, while the small parasitic heat transfer in the “off” state is primarily (77%) due to radiation losses. Lastly, this simple and effective technology can have a strong impact on the feasibility, scalability, and dispatchability of CSP latent storage. In addition, other industrial and commercial applications can benefit from this thermal valve concept.« less

Optimum take-off angle in the long jump.

PubMed

Linthorne, Nicholas P; Guzman, Maurice S; Bridgett, Lisa A

2005-07-01

In this study, we found that the optimum take-off angle for a long jumper may be predicted by combining the equation for the range of a projectile in free flight with the measured relations between take-off speed, take-off height and take-off angle for the athlete. The prediction method was evaluated using video measurements of three experienced male long jumpers who performed maximum-effort jumps over a wide range of take-off angles. To produce low take-off angles the athletes used a long and fast run-up, whereas higher take-off angles were produced using a progressively shorter and slower run-up. For all three athletes, the take-off speed decreased and the take-off height increased as the athlete jumped with a higher take-off angle. The calculated optimum take-off angles were in good agreement with the athletes' competition take-off angles.

Pressure Distribution and Performance Impacts of Aerospike Nozzles on Rotating Detonation Engines

DTIC Science & Technology

2017-06-01

design methodology at both on- and off-design conditions anticipated throughout the combustion cycle. Steady-state, non -reacting computational fluid...operation. Therefore, the nozzle contour was designed using a traditional, steady-state design methodology at both on- and off-design conditions...anticipated throughout the combustion cycle. Steady-state, non -reacting computational fluid dynamics (CFD) simulations were performed on various nozzle

Value of high-sensitivity C-reactive protein assays in predicting atrial fibrillation recurrence: a systematic review and meta-analysis

PubMed Central

Yo, Chia-Hung; Lee, Si-Huei; Chang, Shy-Shin; Lee, Matthew Chien-Hung; Lee, Chien-Chang

2014-01-01

Objectives We performed a systematic review and meta-analysis of studies on high-sensitivity C-reactive protein (hs-CRP) assays to see whether these tests are predictive of atrial fibrillation (AF) recurrence after cardioversion. Design Systematic review and meta-analysis. Data sources PubMed, EMBASE and Cochrane databases as well as a hand search of the reference lists in the retrieved articles from inception to December 2013. Study eligibility criteria This review selected observational studies in which the measurements of serum CRP were used to predict AF recurrence. An hs-CRP assay was defined as any CRP test capable of measuring serum CRP to below 0.6 mg/dL. Primary and secondary outcome measures We summarised test performance characteristics with the use of forest plots, hierarchical summary receiver operating characteristic curves and bivariate random effects models. Meta-regression analysis was performed to explore the source of heterogeneity. Results We included nine qualifying studies comprising a total of 347 patients with AF recurrence and 335 controls. A CRP level higher than the optimal cut-off point was an independent predictor of AF recurrence after cardioversion (summary adjusted OR: 3.33; 95% CI 2.10 to 5.28). The estimated pooled sensitivity and specificity for hs-CRP was 71.0% (95% CI 63% to 78%) and 72.0% (61% to 81%), respectively. Most studies used a CRP cut-off point of 1.9 mg/L to predict long-term AF recurrence (77% sensitivity, 65% specificity), and 3 mg/L to predict short-term AF recurrence (73% sensitivity, 71% specificity). Conclusions hs-CRP assays are moderately accurate in predicting AF recurrence after successful cardioversion. PMID:24556243

Using High Resolution Design Spaces for Aerodynamic Shape Optimization Under Uncertainty

NASA Technical Reports Server (NTRS)

Li, Wu; Padula, Sharon

2004-01-01

This paper explains why high resolution design spaces encourage traditional airfoil optimization algorithms to generate noisy shape modifications, which lead to inaccurate linear predictions of aerodynamic coefficients and potential failure of descent methods. By using auxiliary drag constraints for a simultaneous drag reduction at all design points and the least shape distortion to achieve the targeted drag reduction, an improved algorithm generates relatively smooth optimal airfoils with no severe off-design performance degradation over a range of flight conditions, in high resolution design spaces parameterized by cubic B-spline functions. Simulation results using FUN2D in Euler flows are included to show the capability of the robust aerodynamic shape optimization method over a range of flight conditions.

Vestibular Function Research (VFR) experiment. Phase B: Design definition study

NASA Technical Reports Server (NTRS)

1978-01-01

The Vestibular Functions Research (VFR) Experiment was established to investigate the neurosensory and related physiological processes believed to be associated with the space flight nausea syndrome and to develop logical means for its prediction, prevention and treatment. The VFR Project consists of ground and spaceflight experimentation using frogs as specimens. The phase B Preliminary Design Study provided for the preliminary design of the experiment hardware, preparation of performance and hardware specification and a Phase C/D development plan, establishment of STS (Space Transportation System) interfaces and mission operations, and the study of a variety of hardware, experiment and mission options. The study consist of three major tasks: (1) mission mode trade-off; (2) conceptual design; and (3) preliminary design.

TESTING BALANCE AND FALL RISK IN PERSONS WITH PARKINSON DISEASE, AN ARGUMENT FOR ECOLOGICALLY VALID TESTING

PubMed Central

Foreman, K. Bo; Addison, Odessa; Kim, Han S.; Dibble, Leland E.

2010-01-01

Introduction Despite clear deficits in postural control, most clinical examination tools lack accuracy in identifying persons with Parkinson disease (PD) who have fallen or are at risk for falls. We assert that this is in part due to the lack of ecological validity of the testing. Methods To test this assertion, we examined the responsiveness and predictive validity of the Functional Gait Assessment (FGA), the Pull test, and the Timed up and Go (TUG) during clinically defined ON and OFF medication states. To address responsiveness, ON/OFF medication performance was compared. To address predictive validity, areas under the curve (AUC) of receiver operating characteristic (ROC) curves were compared. Comparisons were made using separate non-parametric tests. Results Thirty-six persons (24 male, 12 female) with PD (22 fallers, 14 non-fallers) participated. Only the FGA was able to detect differences between fallers and non-fallers for both ON/OFF medication testing. The predictive validity of the FGA and the TUG for fall identification was higher during OFF medication compared to ON medication testing. The predictive validity of the FGA was higher than the TUG and the Pull test during ON and OFF medication testing. Discussion In order to most accurately identify fallers, clinicians should test persons with PD in ecologically relevant conditions and tasks. In this study, interpretation of the OFF medication performance and use of the FGA provided more accurate prediction of those who would fall. PMID:21215674

Visual Working Memory Cannot Trade Quantity for Quality.

PubMed

Ramaty, Ayelet; Luria, Roy

2018-01-01

Two main models have been proposed to describe how visual working memory (WM) allocates its capacity: the slot-model and the continuous resource-model. The purpose of the current study was to test a direct prediction of the resource model suggesting that WM can trade-off between the quantity and quality of the encoded information. Previous research reported equivocal results, with studies that failed to find such a trade-off and other studies that reported a trade-off. Following the design of previous studies, in Experiment 1 we replicated this trade-off, by presenting the memory array for 1200 ms. Experiment 2 failed to observe a trade-off between quantity and quality using a memory array interval of 300 ms (a standard interval for visual WM). Experiment 3 again failed to find this trade-off, when reinstating the 1200 ms memory array interval but adding an articulatory suppression manipulation. We argue that while participants can trade quantity for quality, this pattern depends on verbal encoding and transfer to long-term memory processes that were possible to perform only during the long retention interval. When these processes were eliminated, the trade-off disappeared. Thus, we didn't find any evidence that the trade-off between quantity for quality can occur within visual WM.

Integrated modeling tool for performance engineering of complex computer systems

NASA Technical Reports Server (NTRS)

Wright, Gary; Ball, Duane; Hoyt, Susan; Steele, Oscar

1989-01-01

This report summarizes Advanced System Technologies' accomplishments on the Phase 2 SBIR contract NAS7-995. The technical objectives of the report are: (1) to develop an evaluation version of a graphical, integrated modeling language according to the specification resulting from the Phase 2 research; and (2) to determine the degree to which the language meets its objectives by evaluating ease of use, utility of two sets of performance predictions, and the power of the language constructs. The technical approach followed to meet these objectives was to design, develop, and test an evaluation prototype of a graphical, performance prediction tool. The utility of the prototype was then evaluated by applying it to a variety of test cases found in the literature and in AST case histories. Numerous models were constructed and successfully tested. The major conclusion of this Phase 2 SBIR research and development effort is that complex, real-time computer systems can be specified in a non-procedural manner using combinations of icons, windows, menus, and dialogs. Such a specification technique provides an interface that system designers and architects find natural and easy to use. In addition, PEDESTAL's multiview approach provides system engineers with the capability to perform the trade-offs necessary to produce a design that meets timing performance requirements. Sample system designs analyzed during the development effort showed that models could be constructed in a fraction of the time required by non-visual system design capture tools.

Multiple Off-Ice Performance Variables Predict On-Ice Skating Performance in Male and Female Division III Ice Hockey Players

PubMed Central

Janot, Jeffrey M.; Beltz, Nicholas M.; Dalleck, Lance D.

2015-01-01

The purpose of this study was to determine if off-ice performance variables could predict on-ice skating performance in Division III collegiate hockey players. Both men (n = 15) and women (n = 11) hockey players (age = 20.5 ± 1.4 years) participated in the study. The skating tests were agility cornering S-turn, 6.10 m acceleration, 44.80 m speed, modified repeat skate, and 15.20 m full speed. Off-ice variables assessed were years of playing experience, height, weight and percent body fat and off-ice performance variables included vertical jump (VJ), 40-yd dash (36.58m), 1-RM squat, pro-agility, Wingate peak power and peak power percentage drop (% drop), and 1.5 mile (2.4km) run. Results indicated that 40-yd dash (36.58m), VJ, 1.5 mile (2.4km) run, and % drop were significant predictors of skating performance for repeat skate (slowest, fastest, and average time) and 44.80 m speed time, respectively. Four predictive equations were derived from multiple regression analyses: 1) slowest repeat skate time = 2.362 + (1.68 x 40-yd dash time) + (0.005 x 1.5 mile run), 2) fastest repeat skate time = 9.762 - (0.089 x VJ) - (0.998 x 40-yd dash time), 3) average repeat skate time = 7.770 + (1.041 x 40-yd dash time) - (0.63 x VJ) + (0.003 x 1.5 mile time), and 4) 47.85 m speed test = 7.707 - (0.050 x VJ) - (0.01 x % drop). It was concluded that selected off-ice tests could be used to predict on-ice performance regarding speed and recovery ability in Division III male and female hockey players. Key points The 40-yd dash (36.58m) and vertical jump tests are significant predictors of on-ice skating performance specific to speed. In addition to 40-yd dash and vertical jump, the 1.5 mile (2.4km) run for time and percent power drop from the Wingate anaerobic power test were also significant predictors of skating performance that incorporates the aspect of recovery from skating activity. Due to the specificity of selected off-ice variables as predictors of on-ice performance, coaches can elect to assess player performance off-ice and focus on other uses of valuable ice time for their individual teams. PMID:26336338

On the Utilization of In-flight Radiation-induced Performance Data and Anomaly Resolution of Commercial Off the Shelf (COTS) Electronics

NASA Technical Reports Server (NTRS)

LeBel, Kenneth A.; Poivey, Christian; Barth, Janet L.

2003-01-01

This viewgraph presentation presents an overview of the use of in-flight science data to review the radiation effects on commercial off the shelf (COTS) electronics used in recent spacecraft missions. The authors review the hazards that the space radiation environment pose for spacecraft electronics. They specifically discuss long term effects such as total ionizing dose (TID) and short term effects like single particle events (SEE). The advantages of using COTS electronics despite not being radiation hardened are mentioned. The reasons cite for tracking in-flight performance of COTS electronics include: anomaly resolution, validate ground tests and environmental predictions and provide lessons for future designers. Sample radiation impacts of science data from the following missions are analyzed: SOHO/LASCO 3 Coronograph, Microwave Anisotrophy Probe, Hubble Space Telescope and Chandra X-Ray Observatory.

A Hot-Spot Motif Characterizes the Interface between a Designed Ankyrin-Repeat Protein and Its Target Ligand

PubMed Central

Cheung, Luthur Siu-Lun; Kanwar, Manu; Ostermeier, Marc; Konstantopoulos, Konstantinos

2012-01-01

Nonantibody scaffolds such as designed ankyrin repeat proteins (DARPins) can be rapidly engineered to detect diverse target proteins with high specificity and offer an attractive alternative to antibodies. Using molecular simulations, we predicted that the binding interface between DARPin off7 and its ligand (maltose binding protein; MBP) is characterized by a hot-spot motif in which binding energy is largely concentrated on a few amino acids. To experimentally test this prediction, we fused MBP to a transmembrane domain to properly orient the protein into a polymer-cushioned lipid bilayer, and characterized its interaction with off7 using force spectroscopy. Using this, to our knowledge, novel technique along with surface plasmon resonance, we validated the simulation predictions and characterized the effects of select mutations on the kinetics of the off7-MBP interaction. Our integrated approach offers scientific insights on how the engineered protein interacts with the target molecule. PMID:22325262

Intelligent Decisions Need Intelligent Choice of Models and Data - a Bayesian Justifiability Analysis for Models with Vastly Different Complexity

NASA Astrophysics Data System (ADS)

Nowak, W.; Schöniger, A.; Wöhling, T.; Illman, W. A.

2016-12-01

Model-based decision support requires justifiable models with good predictive capabilities. This, in turn, calls for a fine adjustment between predictive accuracy (small systematic model bias that can be achieved with rather complex models), and predictive precision (small predictive uncertainties that can be achieved with simpler models with fewer parameters). The implied complexity/simplicity trade-off depends on the availability of informative data for calibration. If not available, additional data collection can be planned through optimal experimental design. We present a model justifiability analysis that can compare models of vastly different complexity. It rests on Bayesian model averaging (BMA) to investigate the complexity/performance trade-off dependent on data availability. Then, we disentangle the complexity component from the performance component. We achieve this by replacing actually observed data by realizations of synthetic data predicted by the models. This results in a "model confusion matrix". Based on this matrix, the modeler can identify the maximum model complexity that can be justified by the available (or planned) amount and type of data. As a side product, the matrix quantifies model (dis-)similarity. We apply this analysis to aquifer characterization via hydraulic tomography, comparing four models with a vastly different number of parameters (from a homogeneous model to geostatistical random fields). As a testing scenario, we consider hydraulic tomography data. Using subsets of these data, we determine model justifiability as a function of data set size. The test case shows that geostatistical parameterization requires a substantial amount of hydraulic tomography data to be justified, while a zonation-based model can be justified with more limited data set sizes. The actual model performance (as opposed to model justifiability), however, depends strongly on the quality of prior geological information.

The WISGSK: A computer code for the prediction of a multistage axial compressor performance with water ingestion

NASA Technical Reports Server (NTRS)

Tsuchiya, T.; Murthy, S. N. B.

1982-01-01

A computer code is presented for the prediction of off-design axial flow compressor performance with water ingestion. Four processes were considered to account for the aero-thermo-mechanical interactions during operation with air-water droplet mixture flow: (1) blade performance change, (2) centrifuging of water droplets, (3) heat and mass transfer process between the gaseous and the liquid phases and (4) droplet size redistribution due to break-up. Stage and compressor performance are obtained by a stage stacking procedure using representative veocity diagrams at a rotor inlet and outlet mean radii. The Code has options for performance estimation with (1) mixtures of gas and (2) gas-water droplet mixtures, and therefore can take into account the humidity present in ambient conditions. A test case illustrates the method of using the Code. The Code follows closely the methodology and architecture of the NASA-STGSTK Code for the estimation of axial-flow compressor performance with air flow.

Interactive-graphic flowpath plotting for turbine engines

NASA Technical Reports Server (NTRS)

Corban, R. R.

1981-01-01

An engine cycle program capable of simulating the design and off-design performance of arbitrary turbine engines, and a computer code which, when used in conjunction with the cycle code, can predict the weight of the engines are described. A graphics subroutine was added to the code to enable the engineer to visualize the designed engine with more clarity by producing an overall view of the designed engine for output on a graphics device using IBM-370 graphics subroutines. In addition, with the engine drawn on a graphics screen, the program allows for the interactive user to make changes to the inputs to the code for the engine to be redrawn and reweighed. These improvements allow better use of the code in conjunction with the engine program.

Analytical modeling of helium turbomachinery using FORTRAN 77

NASA Astrophysics Data System (ADS)

Balaji, Purushotham

Advanced Generation IV modular reactors, including Very High Temperature Reactors (VHTRs), utilize helium as the working fluid, with a potential for high efficiency power production utilizing helium turbomachinery. Helium is chemically inert and nonradioactive which makes the gas ideal for a nuclear power-plant environment where radioactive leaks are a high concern. These properties of helium gas helps to increase the safety features as well as to decrease the aging process of plant components. The lack of sufficient helium turbomachinery data has made it difficult to study the vital role played by the gas turbine components of these VHTR powered cycles. Therefore, this research work focuses on predicting the performance of helium compressors. A FORTRAN77 program is developed to simulate helium compressor operation, including surge line prediction. The resulting design point and off design performance data can be used to develop compressor map files readable by Numerical Propulsion Simulation Software (NPSS). This multi-physics simulation software that was developed for propulsion system analysis has found applications in simulating power-plant cycles.

A Control-Theoretic Approach for the Combined Management of Quality-of-Service and Energy in Service Centers

NASA Astrophysics Data System (ADS)

Poussot-Vassal, Charles; Tanelli, Mara; Lovera, Marco

The complexity of Information Technology (IT) systems is steadily increasing and system complexity has been recognised as the main obstacle to further advancements of IT. This fact has recently raised energy management issues. Control techniques have been proposed and successfully applied to design Autonomic Computing systems, trading-off system performance with energy saving goals. As users behaviour is highly time varying and workload conditions can change substantially within the same business day, the Linear Parametrically Varying (LPV) framework is particularly promising for modeling such systems. In this chapter, a control-theoretic method to investigate the trade-off between Quality of Service (QoS) requirements and energy saving objectives in the case of admission control in Web service systems is proposed, considering as control variables the server CPU frequency and the admission probability. To quantitatively evaluate the trade-off, a dynamic model of the admission control dynamics is estimated via LPV identification techniques. Based on this model, an optimisation problem within the Model Predictive Control (MPC) framework is setup, by means of which it is possible to investigate the optimal trade-off policy to manage QoS and energy saving objectives at design time and taking into explicit account the system dynamics.

Small wind turbine performance evaluation using field test data and a coupled aero-electro-mechanical model

NASA Astrophysics Data System (ADS)

Wallace, Brian D.

A series of field tests and theoretical analyses were performed on various wind turbine rotor designs at two Penn State residential-scale wind-electric facilities. This work involved the prediction and experimental measurement of the electrical and aerodynamic performance of three wind turbines; a 3 kW rated Whisper 175, 2.4 kW rated Skystream 3.7, and the Penn State designed Carolus wind turbine. Both the Skystream and Whisper 175 wind turbines are OEM blades which were originally installed at the facilities. The Carolus rotor is a carbon-fiber composite 2-bladed machine, designed and assembled at Penn State, with the intent of replacing the Whisper 175 rotor at the off-grid system. Rotor aerodynamic performance is modeled using WT_Perf, a National Renewable Energy Laboratory developed Blade Element Momentum theory based performance prediction code. Steady-state power curves are predicted by coupling experimentally determined electrical characteristics with the aerodynamic performance of the rotor simulated with WT_Perf. A dynamometer test stand is used to establish the electromechanical efficiencies of the wind-electric system generator. Through the coupling of WT_Perf and dynamometer test results, an aero-electro-mechanical analysis procedure is developed and provides accurate predictions of wind system performance. The analysis of three different wind turbines gives a comprehensive assessment of the capability of the field test facilities and the accuracy of aero-electro-mechanical analysis procedures. Results from this study show that the Carolus and Whisper 175 rotors are running at higher tip-speed ratios than are optimum for power production. The aero-electro-mechanical analysis predicted the high operating tip-speed ratios of the rotors and was accurate at predicting output power for the systems. It is shown that the wind turbines operate at high tip-speeds because of a miss-match between the aerodynamic drive torque and the operating torque of the wind-system generator. Through the change of load impedance on the wind generator, the research facility has the ability to modify the rotational speed of the wind turbines, allowing the rotors to perform closer to their optimum tip-speed. Comparisons between field test data and performance predictions show that the aero-electro-mechanical analysis was able to predict differences in power production and rotational speed which result from changes in the system load impedance.

Experimental evaluation of expendable supersonic nozzle concepts

NASA Technical Reports Server (NTRS)

Baker, V.; Kwon, O.; Vittal, B.; Berrier, B.; Re, R.

1990-01-01

Exhaust nozzles for expendable supersonic turbojet engine missile propulsion systems are required to be simple, short and compact, in addition to having good broad-range thrust-minus-drag performance. A series of convergent-divergent nozzle scale model configurations were designed and wind tunnel tested for a wide range of free stream Mach numbers and nozzle pressure ratios. The models included fixed geometry and simple variable exit area concepts. The experimental and analytical results show that the fixed geometry configurations tested have inferior off-design thrust-minus-drag performance in the transonic Mach range. A simple variable exit area configuration called the Axi-Quad nozzle, combining features of both axisymmetric and two-dimensional convergent-divergent nozzles, performed well over a broad range of operating conditions. Analytical predictions of the flow pattern as well as overall performance of the nozzles, using a fully viscous, compressible CFD code, compared very well with the test data.

Global Design Optimization for Fluid Machinery Applications

NASA Technical Reports Server (NTRS)

Shyy, Wei; Papila, Nilay; Tucker, Kevin; Vaidyanathan, Raj; Griffin, Lisa

2000-01-01

Recent experiences in utilizing the global optimization methodology, based on polynomial and neural network techniques for fluid machinery design are summarized. Global optimization methods can utilize the information collected from various sources and by different tools. These methods offer multi-criterion optimization, handle the existence of multiple design points and trade-offs via insight into the entire design space can easily perform tasks in parallel, and are often effective in filtering the noise intrinsic to numerical and experimental data. Another advantage is that these methods do not need to calculate the sensitivity of each design variable locally. However, a successful application of the global optimization method needs to address issues related to data requirements with an increase in the number of design variables and methods for predicting the model performance. Examples of applications selected from rocket propulsion components including a supersonic turbine and an injector element and a turbulent flow diffuser are used to illustrate the usefulness of the global optimization method.

Analysis of oil lubricated, fluid film, thrust bearings with allowance for temperature dependent viscosity

NASA Technical Reports Server (NTRS)

Pan, C. H. T.; Malanoski, S. B.

1972-01-01

A preliminary design study was performed to seek a fluid-film thrust bearing design intended to be part of a high-speed, hybrid (rolling element/fluid film) bearing configuration. The base line used is a design previously tested. To improve the accuracy of theoretical predictions of load capacity, flow rate, and friction power loss, an analytical procedure was developed to include curvature effects inherent in thrust bearings and to allow for the temperature rise in the fluid due to viscous heating. Also, a narrow-groove approximation in the treatment of the temperature field was formulated to apply the procedure to the Whipple thrust bearing. A comparative trade-off study was carried out assuming isothermal films; its results showed the shrouded-step design to be superior to the Whipple design for the intended application. An extensive parametric study was performed, employing isoviscous calculations, to determine the optimized design, which was subsequently recalculated allowing for temperature effects.

An iterative synthetic approach to engineer a high-performing PhoB-specific reporter.

PubMed

Stoudenmire, Julie L; Essock-Burns, Tara; Weathers, Erena N; Solaimanpour, Sina; Mrázek, Jan; Stabb, Eric V

2018-05-11

Transcriptional reporters are common tools for analyzing either the transcription of a gene of interest or the activity of a specific transcriptional regulator. Unfortunately, the latter application has the shortcoming that native promoters did not evolve as optimal readouts for the activity of a particular regulator. We sought to synthesize an optimized transcriptional reporter for assessing PhoB activity, aiming for maximal "on" expression when PhoB is active, minimal background in the "off" state, and no control elements for other regulators. We designed specific sequences for promoter elements with appropriately spaced PhoB-binding sites, and at nineteen additional intervening nucleotide positions for which we did not predict sequence-specific effects the bases were randomized. Eighty-three such constructs were screened in Vibrio fischeri , enabling us to identify bases at particular randomized positions that significantly correlated with high "on" or low "off" expression. A second round of promoter design rationally constrained thirteen additional positions, leading to a reporter with high PhoB-dependent expression, essentially no background, and no other known regulatory elements. As expressed reporters, we used both stable and destabilized GFP, the latter with a half-life of eighty-one minutes in V. fischeri In culture, PhoB induced the reporter when phosphate was depleted below 10 μM. During symbiotic colonization of its host squid Euprymna scolopes , the reporter indicated heterogeneous phosphate availability in different light-organ microenvironments. Finally, testing this construct in other Proteobacteria demonstrated its broader utility. The results illustrate how a limited ability to predict synthetic promoter-reporter performance can be overcome through iterative screening and re-engineering. IMPORTANCE Transcriptional reporters can be powerful tools for assessing when a particular regulator is active; however, native promoters may not be ideal for this purpose. Optimal reporters should be specific to the regulator being examined and should maximize the difference between "on" and "off" states; however, these properties are distinct from the selective pressures driving the evolution of natural promoters. Synthetic promoters offer a promising alternative, but our understanding often does not enable fully predictive promoter design, and the large number of alternative sequence possibilities can be intractable. In a synthetic promoter region with over thirty-four billion sequence variants, we identified bases correlated with favorable performance by screening only eighty-three candidates, allowing us to rationally constrain our design. We thereby generated an optimized reporter that is induced by PhoB and used it to explore the low-phosphate response of V. fischeri This promoter-design strategy will facilitate the engineering of other regulator-specific reporters. Copyright © 2018 American Society for Microbiology.

Context influences on TALE–DNA binding revealed by quantitative profiling

PubMed Central

Rogers, Julia M.; Barrera, Luis A.; Reyon, Deepak; Sander, Jeffry D.; Kellis, Manolis; Joung, J Keith; Bulyk, Martha L.

2015-01-01

Transcription activator-like effector (TALE) proteins recognize DNA using a seemingly simple DNA-binding code, which makes them attractive for use in genome engineering technologies that require precise targeting. Although this code is used successfully to design TALEs to target specific sequences, off-target binding has been observed and is difficult to predict. Here we explore TALE–DNA interactions comprehensively by quantitatively assaying the DNA-binding specificities of 21 representative TALEs to ∼5,000–20,000 unique DNA sequences per protein using custom-designed protein-binding microarrays (PBMs). We find that protein context features exert significant influences on binding. Thus, the canonical recognition code does not fully capture the complexity of TALE–DNA binding. We used the PBM data to develop a computational model, Specificity Inference For TAL-Effector Design (SIFTED), to predict the DNA-binding specificity of any TALE. We provide SIFTED as a publicly available web tool that predicts potential genomic off-target sites for improved TALE design. PMID:26067805

Context influences on TALE-DNA binding revealed by quantitative profiling.

PubMed

Rogers, Julia M; Barrera, Luis A; Reyon, Deepak; Sander, Jeffry D; Kellis, Manolis; Joung, J Keith; Bulyk, Martha L

2015-06-11

Transcription activator-like effector (TALE) proteins recognize DNA using a seemingly simple DNA-binding code, which makes them attractive for use in genome engineering technologies that require precise targeting. Although this code is used successfully to design TALEs to target specific sequences, off-target binding has been observed and is difficult to predict. Here we explore TALE-DNA interactions comprehensively by quantitatively assaying the DNA-binding specificities of 21 representative TALEs to ∼5,000-20,000 unique DNA sequences per protein using custom-designed protein-binding microarrays (PBMs). We find that protein context features exert significant influences on binding. Thus, the canonical recognition code does not fully capture the complexity of TALE-DNA binding. We used the PBM data to develop a computational model, Specificity Inference For TAL-Effector Design (SIFTED), to predict the DNA-binding specificity of any TALE. We provide SIFTED as a publicly available web tool that predicts potential genomic off-target sites for improved TALE design.

High-Fidelity Aerostructural Design Optimization of Transport Aircraft with Continuous Morphing Trailing Edge Technology

NASA Astrophysics Data System (ADS)

Burdette, David A., Jr.

Adaptive morphing trailing edge technology offers the potential to decrease the fuel burn of transonic commercial transport aircraft by allowing wings to dynamically adjust to changing flight conditions. Current configurations allow flap and aileron droop; however, this approach provides limited degrees of freedom and increased drag produced by gaps in the wing's surface. Leading members in the aeronautics community including NASA, AFRL, Boeing, and a number of academic institutions have extensively researched morphing technology for its potential to improve aircraft efficiency. With modern computational tools it is possible to accurately and efficiently model aircraft configurations in order to quantify the efficiency improvements offered by mor- phing technology. Coupled high-fidelity aerodynamic and structural solvers provide the capability to model and thoroughly understand the nuanced trade-offs involved in aircraft design. This capability is important for a detailed study of the capabilities of morphing trailing edge technology. Gradient-based multidisciplinary design opti- mization provides the ability to efficiently traverse design spaces and optimize the trade-offs associated with the design. This thesis presents a number of optimization studies comparing optimized config- urations with and without morphing trailing edge devices. The baseline configuration used throughout this work is the NASA Common Research Model. The first opti- mization comparison considers the optimal fuel burn predicted by the Breguet range equation at a single cruise point. This initial singlepoint optimization comparison demonstrated a limited fuel burn savings of less than 1%. Given the effectiveness of the passive aeroelastic tailoring in the optimized non-morphing wing, the singlepoint optimization offered limited potential for morphing technology to provide any bene- fit. To provide a more appropriate comparison, a number of multipoint optimizations were performed. With a 3-point stencil, the morphing wing burned 2.53% less fuel than its optimized non-morphing counterpart. Expanding further to a 7-point stencil, the morphing wing used 5.04% less fuel. Additional studies demonstrate that the size of the morphing device can be reduced without sizable performance reductions, and that as aircraft wings' aspect ratios increase, the effectiveness of morphing trailing edge devices increases. The final set of studies in this thesis consider mission analy- sis, including climb, multi-altitude cruise, and descent. These mission analyses were performed with a number of surrogate models, trained with O(100) optimizations. These optimizations demonstrated fuel burn reductions as large as 5% at off-design conditions. The fuel burn predicted by the mission analysis was up to 2.7% lower for the morphing wing compared to the conventional configuration.

Representative learning design in springboard diving: Is dry-land training representative of a pool dive?

PubMed

Barris, Sian; Davids, Keith; Farrow, Damian

2013-01-01

Two distinctly separate training facilities (dry-land and aquatic) are routinely used in springboard diving and pose an interesting problem for learning, given the inherent differences in landing (head first vs. feet first) imposed by the different task constraints. Although divers may practise the same preparation phase, take-off and initial aerial rotation in both environments, there is no evidence to suggest that the tasks completed in the dry-land training environment are representative of those performed in the aquatic competition environment. The aim of this study was to compare the kinematics of the preparation phase of reverse dives routinely practised in each environment. Despite their high skill level, it was predicted that individual analyses of elite springboard divers would reveal differences in the joint coordination and board-work between take-offs. The two-dimensional kinematic characteristics were recorded during normal training sessions and used for intra-individual analysis. Kinematic characteristics of the preparatory take-off phase revealed differences in board-work (step lengths, jump height, board depression angles) for all participants at key events. However, the presence of scaled global topological characteristics suggested that all participants adopted similar joint coordination patterns in both environments. These findings suggest that the task constraints of wet and dry training environments are not similar, and highlight the need for coaches to consider representative learning designs in high performance diving programmes.

Numerical Assessment of Four-Port Through-Flow Wave Rotor Cycles with Passage Height Variation

NASA Technical Reports Server (NTRS)

Paxson, D. E.; Lindau, Jules W.

1997-01-01

The potential for improved performance of wave rotor cycles through the use of passage height variation is examined. A Quasi-one-dimensional CFD code with experimentally validated loss models is used to determine the flowfield in the wave rotor passages. Results indicate that a carefully chosen passage height profile can produce substantial performance gains. Numerical performance data are presented for a specific profile, in a four-port, through-flow cycle design which yielded a computed 4.6% increase in design point pressure ratio over a comparably sized rotor with constant passage height. In a small gas turbine topping cycle application, this increased pressure ratio would reduce specific fuel consumption to 22% below the un-topped engine; a significant improvement over the already impressive 18% reductions predicted for the constant passage height rotor. The simulation code is briefly described. The method used to obtain rotor passage height profiles with enhanced performance is presented. Design and off-design results are shown using two different computational techniques. The paper concludes with some recommendations for further work.

Cold flow testing of the Space Shuttle Main Engine alternate turbopump development high pressure fuel turbine model

NASA Technical Reports Server (NTRS)

Gaddis, Stephen W.; Hudson, Susan T.; Johnson, P. D.

1992-01-01

NASA's Marshall Space Flight Center has established a cold airflow turbine test program to experimentally determine the performance of liquid rocket engine turbopump drive turbines. Testing of the SSME alternate turbopump development (ATD) fuel turbine was conducted for back-to-back comparisons with the baseline SSME fuel turbine results obtained in the first quarter of 1991. Turbine performance, Reynolds number effects, and turbine diagnostics, such as stage reactions and exit swirl angles, were investigated at the turbine design point and at off-design conditions. The test data showed that the ATD fuel turbine test article was approximately 1.4 percent higher in efficiency and flowed 5.3 percent more than the baseline fuel turbine test article. This paper describes the method and results used to validate the ATD fuel turbine aerodynamic design. The results are being used to determine the ATD high pressure fuel turbopump (HPFTP) turbine performance over its operating range, anchor the SSME ATD steady-state performance model, and validate various prediction and design analyses.

Wicket gate trailing-edge blowing: A method for improving off-design hydroturbine performance by adjusting the runner inlet swirl angle

NASA Astrophysics Data System (ADS)

Lewis, B. J.; Cimbala, J. M.; Wouden, A. M.

2014-03-01

At their best efficiency point (BEP), hydroturbines operate at very high efficiency. However, with the ever-increasing penetration of alternative electricity generation, it has become common to operate hydroturbines at off-design conditions in order to maintain stability in the electric power grid. This paper demonstrates a method for improving hydroturbine performance during off-design operation by injecting water through slots at the trailing edges of the wicket gates. The injected water causes a change in bulk flow direction at the inlet of the runner. This change in flow angle from the wicket gate trailing-edge jets provides the capability of independently varying the flow rate and swirl angle through the runner, which in current designs are both determined by the wicket gate opening angle. When properly tuned, altering the flow angle results in a significant improvement in turbine efficiency during off-design operation.

High-Fidelity Aerodynamic Shape Optimization for Natural Laminar Flow

NASA Astrophysics Data System (ADS)

Rashad, Ramy

To ensure the long-term sustainability of aviation, serious effort is underway to mitigate the escalating economic, environmental, and social concerns of the industry. Significant improvement to the energy efficiency of air transportation is required through the research and development of advanced and unconventional airframe and engine technologies. In the quest to reduce airframe drag, this thesis is concerned with the development and demonstration of an effective design tool for improving the aerodynamic efficiency of subsonic and transonic airfoils. The objective is to advance the state-of-the-art in high-fidelity aerodynamic shape optimization by incorporating and exploiting the phenomenon of laminar-turbulent transition in an efficient manner. A framework for the design and optimization of Natural Laminar Flow (NLF) airfoils is developed and demonstrated with transition prediction capable of accounting for the effects of Reynolds number, freestream turbulence intensity, Mach number, and pressure gradients. First, a two-dimensional Reynolds-averaged Navier-Stokes (RANS) flow solver has been extended to incorporate an iterative laminar-turbulent transition prediction methodology. The natural transition locations due to Tollmien-Schlichting instabilities are predicted using the simplified eN envelope method of Drela and Giles or, alternatively, the compressible form of the Arnal-Habiballah-Delcourt criterion. The boundary-layer properties are obtained directly from the Navier-Stokes flow solution, and the transition to turbulent flow is modeled using an intermittency function in conjunction with the Spalart-Allmaras turbulence model. The RANS solver is subsequently employed in a gradient-based sequential quadratic programming shape optimization framework. The laminar-turbulent transition criteria are tightly coupled into the objective and gradient evaluations. The gradients are obtained using a new augmented discrete-adjoint formulation for non-local transition criteria. Using the eN transition criterion, the proposed framework is applied to the single and multipoint optimization of subsonic and transonic airfoils, leading to robust NLF designs. The aerodynamic design requirements over a range of cruise flight conditions are cast into a multipoint optimization problem through a composite objective defined using a weighted integral of the operating points. To study and quantify off-design performance, a Pareto front is formed using a weighted objective combining free-transition and fully-turbulent operating conditions. Next we examine the sensitivity of NLF design to the freestream disturbance environment, highlighting the on- and off-design performance at different critical N-factors. Finally, we propose and demonstrate a technique to enable the design of airfoils with robust performance over a range of critical N-factors.

GENENG: A program for calculating design and off-design performance for turbojet and turbofan engines

NASA Technical Reports Server (NTRS)

Koenig, R. W.; Fishbach, L. H.

1972-01-01

A computer program entitled GENENG employs component performance maps to perform analytical, steady state, engine cycle calculations. Through a scaling procedure, each of the component maps can be used to represent a family of maps (different design values of pressure ratios, efficiency, weight flow, etc.) Either convergent or convergent-divergent nozzles may be used. Included is a complete FORTRAN 4 listing of the program. Sample results and input explanations are shown for one-spool and two-spool turbojets and two-spool separate- and mixed-flow turbofans operating at design and off-design conditions.

Numerical Modeling of Propellant Boil-Off in a Cryogenic Storage Tank

NASA Technical Reports Server (NTRS)

Majumdar, A. K.; Steadman, T. E.; Maroney, J. L.; Sass, J. P.; Fesmire, J. E.

2007-01-01

A numerical model to predict boil-off of stored propellant in large spherical cryogenic tanks has been developed. Accurate prediction of tank boil-off rates for different thermal insulation systems was the goal of this collaboration effort. The Generalized Fluid System Simulation Program, integrating flow analysis and conjugate heat transfer for solving complex fluid system problems, was used to create the model. Calculation of tank boil-off rate requires simultaneous simulation of heat transfer processes among liquid propellant, vapor ullage space, and tank structure. The reference tank for the boil-off model was the 850,000 gallon liquid hydrogen tank at Launch Complex 39B (LC- 39B) at Kennedy Space Center, which is under study for future infrastructure improvements to support the Constellation program. The methodology employed in the numerical model was validated using a sub-scale model and tank. Experimental test data from a 1/15th scale version of the LC-39B tank using both liquid hydrogen and liquid nitrogen were used to anchor the analytical predictions of the sub-scale model. Favorable correlations between sub-scale model and experimental test data have provided confidence in full-scale tank boil-off predictions. These methods are now being used in the preliminary design for other cases including future launch vehicles

Deviation from goal pace, body temperature and body mass loss as predictors of road race performance.

PubMed

Adams, William M; Hosokawa, Yuri; Belval, Luke N; Huggins, Robert A; Stearns, Rebecca L; Casa, Douglas J

2017-03-01

The purpose of this study was to examine the relationship between pacing, gastrointestinal temperature (T GI ), and percent body mass loss (%BML) on relative race performance during a warm weather 11.3km road race. Observational study of a sample of active runners competing in the 2014 Falmouth Road Race. Participants ingested a T GI pill and donned a GPS enabled watch with heart rate monitoring capabilities prior to the start of the race. Percent off predicted pace (% OFF ) was calculated for seven segments of the race. Separate linear regression analyses were used to assess the relationship between pace, T ​GI , and %BML on relative race performance. One-way ANOVA was used to analyse post race T GI (≥40°C vs <40°C) on pace and % OFF . Larger %BML was associated with faster finish times (R 2 =0.19, p=0.018), faster average pace (R 2 =0.29, p=0.012), and a greater % OFF (R 2 =0.15, p=0.033). % OFF during the first mile (1.61km) significantly predicted overall finish time (R 2 =0.64, p<0.001) while % OFF during the second mile (3.22km) (R 2 change=0.18, p<0.001) further added to the model (R 2 =0.82, p<0.001). Body temperature (pre race T GI and post race T GI ) was not predictive of overall finish time (p>0.05). There was a trend in a slower pace (p=0.055) and greater % OFF (p=0.056) in runners finishing the race with a T GI >40°C. Overall, finish time was influenced by greater variations in pace during the first two miles of the race. In addition, runners who minimized fluid losses and had lower T GI were associated with meeting self-predicted goals. Copyright © 2016 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

Benchmarking CRISPR on-target sgRNA design.

PubMed

Yan, Jifang; Chuai, Guohui; Zhou, Chi; Zhu, Chenyu; Yang, Jing; Zhang, Chao; Gu, Feng; Xu, Han; Wei, Jia; Liu, Qi

2017-02-15

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-based gene editing has been widely implemented in various cell types and organisms. A major challenge in the effective application of the CRISPR system is the need to design highly efficient single-guide RNA (sgRNA) with minimal off-target cleavage. Several tools are available for sgRNA design, while limited tools were compared. In our opinion, benchmarking the performance of the available tools and indicating their applicable scenarios are important issues. Moreover, whether the reported sgRNA design rules are reproducible across different sgRNA libraries, cell types and organisms remains unclear. In our study, a systematic and unbiased benchmark of the sgRNA predicting efficacy was performed on nine representative on-target design tools, based on six benchmark data sets covering five different cell types. The benchmark study presented here provides novel quantitative insights into the available CRISPR tools. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Real-World Application of Robust Design Optimization Assisted by Response Surface Approximation and Visual Data-Mining

NASA Astrophysics Data System (ADS)

Shimoyama, Koji; Jeong, Shinkyu; Obayashi, Shigeru

A new approach for multi-objective robust design optimization was proposed and applied to a real-world design problem with a large number of objective functions. The present approach is assisted by response surface approximation and visual data-mining, and resulted in two major gains regarding computational time and data interpretation. The Kriging model for response surface approximation can markedly reduce the computational time for predictions of robustness. In addition, the use of self-organizing maps as a data-mining technique allows visualization of complicated design information between optimality and robustness in a comprehensible two-dimensional form. Therefore, the extraction and interpretation of trade-off relations between optimality and robustness of design, and also the location of sweet spots in the design space, can be performed in a comprehensive manner.

Predicting performance of axial pump inducer of LOX booster turbo-pump of staged combustion cycle based rocket engine using CFD

NASA Astrophysics Data System (ADS)

Mishra, Arpit; Ghosh, Parthasarathi

2015-12-01

For low cost, high thrust, space missions with high specific impulse and high reliability, inert weight needs to be minimized and thereby increasing the delivered payload. Turbopump feed system for a liquid propellant rocket engine (LPRE) has the highest power to weight ratio. Turbopumps are primarily equipped with an axial flow inducer to achieve the high angular velocity and low suction pressure in combination with increased system reliability. Performance of the turbopump strongly depends on the performance of the inducer. Thus, for designing a LPRE turbopump, demands optimization of the inducer geometry based on the performance of different off-design operating regimes. In this paper, steady-state CFD analysis of the inducer of a liquid oxygen (LOX) axial pump used as a booster pump for an oxygen rich staged combustion cycle rocket engine has been presented using ANSYS® CFX. Attempts have been made to obtain the performance characteristic curves for the LOX pump inducer. The formalism has been used to predict the performance of the inducer for the throttling range varying from 80% to 113% of nominal thrust and for the different rotational velocities from 4500 to 7500 rpm. The results have been analysed to determine the region of cavitation inception for different inlet pressure.

Improved, ACMG-Compliant, in silico prediction of pathogenicity for missense substitutions encoded by TP53 variants.

PubMed

Fortuno, Cristina; James, Paul A; Young, Erin L; Feng, Bing; Olivier, Magali; Pesaran, Tina; Tavtigian, Sean V; Spurdle, Amanda B

2018-05-18

Clinical interpretation of germline missense variants represents a major challenge, including those in the TP53 Li-Fraumeni syndrome gene. Bioinformatic prediction is a key part of variant classification strategies. We aimed to optimize the performance of the Align-GVGD tool used for p53 missense variant prediction, and compare its performance to other bioinformatic tools (SIFT, PolyPhen-2) and ensemble methods (REVEL, BayesDel). Reference sets of assumed pathogenic and assumed benign variants were defined using functional and/or clinical data. Area under the curve and Matthews correlation coefficient (MCC) values were used as objective functions to select an optimized protein multi-sequence alignment with best performance for Align-GVGD. MCC comparison of tools using binary categories showed optimized Align-GVGD (C15 cut-off) combined with BayesDel (0.16 cut-off), or with REVEL (0.5 cut-off), to have the best overall performance. Further, a semi-quantitative approach using multiple tiers of bioinformatic prediction, validated using an independent set of non-functional and functional variants, supported use of Align-GVGD and BayesDel prediction for different strength of evidence levels in ACMG/AMP rules. We provide rationale for bioinformatic tool selection for TP53 variant classification, and have also computed relevant bioinformatic predictions for every possible p53 missense variant to facilitate their use by the scientific and medical community. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

A numerical model for dynamic wave rotor analysis

NASA Technical Reports Server (NTRS)

Paxson, D. E.

1995-01-01

A numerical model has been developed which can predict the dynamic (and steady state) performance of a wave rotor, given the geometry and time dependent boundary conditions. The one-dimensional, perfect gas, CFD based code tracks the gasdynamics in each of the wave rotor passages as they rotate past the various ducts. The model can operate both on and off-design, allowing dynamic behavior to be studied throughout the operating range of the wave rotor. The model accounts for several major loss mechanisms including finite passage opening time, fluid friction, heat transfer to and from the passage walls, and leakage to and from the passage ends. In addition, it can calculate the amount of work transferred to and from the fluid when the flow in the ducts is not aligned with the passages such as occurs in off-design operation. Since it is one-dimensional, the model runs reasonably fast on a typical workstation. This paper will describe the model and present the results of some transient calculations for a conceptual four port wave rotor designed as a topping cycle for a small gas turbine engine.

A predictive wheel-soil interaction model for planetary rovers validated in testbeds and against MER Mars rover performance data

NASA Astrophysics Data System (ADS)

Richter, L.; Ellery, A.; Gao, Y.; Michaud, S.; Schmitz, N.; Weiss, S.

Successful designs of vehicles intended for operations on planetary objects outside the Earth demand, just as for terrestrial off-the-road vehicles, a careful assessment of the terrain relevant for the vehicle mission and predictions of the mobility performance to allow rational trade-off's to be made for the choice of the locomotion concept and sizing. Principal issues driving the chassis design for rovers are the stress-strain properties of the planetary surface soil, the distribution of rocks in the terrain representing potential obstacles to movement, and the gravity level on the celestial object in question. Thus far, planetary rovers have been successfully designed and operated for missions to the Earth's moon and to the planet Mars, including NASA's Mars Exploration Rovers (MER's) `Spirit' and `Opportunity' being in operation on Mars since their landings in January 2004. Here we report on the development of a wheel-soil interaction model with application to wheel sizes and wheel loads relevant to current and near-term robotic planetary rovers, i.e. wheel diameters being between about 200 and 500 mm and vertical quasistatic wheel loads in operation of roughly 100 to 200 N. Such a model clearly is indispensable for sizings of future rovers to analyse the aspect of rover mobility concerned with motion across soils. This work is presently funded by the European Space Agency (ESA) as part of the `Rover Chassis Evaluation Tools' (RCET) effort which has developed a set of S/W-implemented models for predictive mobility analysis of rovers in terms of movement on soils and across obstacles, coupled with dedicated testbeds to validate the wheel-soil models. In this paper, we outline the details of the wheel-soil modelling performed within the RCET work and present comparisons of predictions of wheel performance (motion resistance, torque vs. slip and drawbar pull vs. slip) for specific test cases with the corresponding measurements performed in the RCET single wheel testbed and in the RCET system-level testbed, the latter permitting drawbar pull vs. slip measurements for complete rover development vehicles under controlled and homogeneous soil conditions. Required modifications of the wheel-soil model, in particular related to modelling the effect of wheel slip, are discussed. To strengthen the model validation base, we have run single wheel measurements using a spare MER Mars rover wheel and have performed comparisons with MER actual mobility performance data, available through one of us (LR) who is a member of the MER Athena science team. Corresponding results will be presented. Keywords: rovers, wheel, soil, mobility, vehicle performance, RCET (Rover Chassis Evaluation Tools), MER (Mars Exploration Rover mission) 2

Design Trade-off Between Performance and Fault-Tolerance of Space Onboard Computers

NASA Astrophysics Data System (ADS)

Gorbunov, M. S.; Antonov, A. A.

2017-01-01

It is well known that there is a trade-off between performance and power consumption in onboard computers. The fault-tolerance is another important factor affecting performance, chip area and power consumption. Involving special SRAM cells and error-correcting codes is often too expensive with relation to the performance needed. We discuss the possibility of finding the optimal solutions for modern onboard computer for scientific apparatus focusing on multi-level cache memory design.

A Computer Code for Gas Turbine Engine Weight And Disk Life Estimation

NASA Technical Reports Server (NTRS)

Tong, Michael T.; Ghosn, Louis J.; Halliwell, Ian; Wickenheiser, Tim (Technical Monitor)

2002-01-01

Reliable engine-weight estimation at the conceptual design stage is critical to the development of new aircraft engines. It helps to identify the best engine concept amongst several candidates. In this paper, the major enhancements to NASA's engine-weight estimate computer code (WATE) are described. These enhancements include the incorporation of improved weight-calculation routines for the compressor and turbine disks using the finite-difference technique. Furthermore, the stress distribution for various disk geometries was also incorporated, for a life-prediction module to calculate disk life. A material database, consisting of the material data of most of the commonly-used aerospace materials, has also been incorporated into WATE. Collectively, these enhancements provide a more realistic and systematic way to calculate the engine weight. They also provide additional insight into the design trade-off between engine life and engine weight. To demonstrate the new capabilities, the enhanced WATE code is used to perform an engine weight/life trade-off assessment on a production aircraft engine.

Mathematical Modeling of Electrochemical Flow Capacitors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoyt, NC; Wainright, JS; Savinell, RF

Electrochemical flow capacitors (EFCs) for grid-scale energy storage are a new technology that is beginning to receive interest. Prediction of the expected performance of such systems is important as modeling can be a useful avenue in the search for design improvements. Models based off of circuit analogues exist to predict EFC performance, but these suffer from deficiencies (e.g. a multitude of fitting constants that are required and the ability to analyze only one spatial direction at a time). In this paper mathematical models based off of three-dimensional macroscopic balances (similar to models for porous electrodes) are reported. Unlike existing three-dimensionalmore » porous electrode-based approaches for modeling slurry electrodes, advection (i.e., transport associated with bulk fluid motion) of the overpotential is included in order to account for the surface charge at the interface between flowing particles and the electrolyte. Doing so leads to the presence of overpotential boundary layers that control the performance of EFCs. These models were used to predict the charging behavior of an EFC under both flowing and non-flowing conditions. Agreement with experimental data was good, including proper prediction of the steady-state current that is achieved during charging of a flowing EFC. (C) The Author(s) 2015. Published by ECS. This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives 4.0 License (CC BY-NC-ND, http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is not changed in any way and is properly cited. For permission for commercial reuse, please email: oa@electrochem.org. All rights reserved.« less

Three-Man Solid Electrolyte Carbon Dioxide Electrolysis Breadboard

NASA Technical Reports Server (NTRS)

Isenberg, Arnold O.

1989-01-01

The development of the Three-Man (2.2 lb CO2/man-day) Solid Electrolyte CO2 Electrolysis Breadboard consisted of a Phase 1 and 2 effort. The Phase 1 effort constituted fabrication of three electrolysis cell types and performing parametric testing, off-design testing, and cell life testing. The Phase 2 consisted of the preliminary design, incorporation of palladium (Pd) tubes for hydrogen separation from the electrolyzer cathode feed gases, design support testing, final design, fabrication, and performance testing of the breadboard system. The results of performance tests demonstrated that CO2 electrolysis in an oxygen reclamation system for long duration space-based habitats is feasible. Closure of the oxygen system loop, therefore, can be achieved by CO2 electrolysis. In a two step process the metabolic CO2 and H2O vapor are electrolyzed into O2, H2, and CO. The CO can subsequently be disproportionated into carbon and CO2 in a carbon deposition reactor and the CO2 in turn be recycled and electrolyzed for total O2 recovery. The development effort demonstrated electrolyzer system can be designed and built to operate safely and reliably and the incorporation of Pd tubes for hydrogen diffusion can be integrated safely with predictable performance.

Experimental Investigation of a High Pressure Ratio Aspirated Fan Stage

NASA Technical Reports Server (NTRS)

Merchant, Ali; Kerrebrock, Jack L.; Adamczyk, John J.; Braunscheidel, Edward

2004-01-01

The experimental investigation of an aspirated fan stage designed to achieve a pressure ratio of 3.4:1 at 1500 ft/sec is presented in this paper. The low-energy viscous flow is aspirated from diffusion-limiting locations on the blades and flowpath surfaces of the stage, enabling a very high pressure ratio to be achieved in a single stage. The fan stage performance was mapped at various operating speeds from choke to stall in a compressor facility at fully simulated engine conditions. The experimentally determined stage performance, in terms of pressure ratio and corresponding inlet mass flow rate, was found to be in good agreement with the three-dimensional viscous computational prediction, and in turn close to the design intent. Stage pressure ratios exceeding 3:1 were achieved at design speed, with an aspiration flow fraction of 3.5 percent of the stage inlet mass flow. The experimental performance of the stage at various operating conditions, including detailed flowfield measurements, are presented and discussed in the context of the computational analyses. The sensitivity of the stage performance and operability to reduced aspiration flow rates at design and off design conditions are also discussed.

Development of a solar-powered residential air conditioner: System optimization preliminary specification

NASA Technical Reports Server (NTRS)

Rousseau, J.; Hwang, K. C.

1975-01-01

Investigations aimed at the optimization of a baseline Rankine cycle solar powered air conditioner and the development of a preliminary system specification were conducted. Efforts encompassed the following: (1) investigations of the use of recuperators/regenerators to enhance the performance of the baseline system, (2) development of an off-design computer program for system performance prediction, (3) optimization of the turbocompressor design to cover a broad range of conditions and permit operation at low heat source water temperatures, (4) generation of parametric data describing system performance (COP and capacity), (5) development and evaluation of candidate system augmentation concepts and selection of the optimum approach, (6) generation of auxiliary power requirement data, (7) development of a complete solar collector-thermal storage-air conditioner computer program, (8) evaluation of the baseline Rankine air conditioner over a five day period simulating the NASA solar house operation, and (9) evaluation of the air conditioner as a heat pump.

Performance trade-offs and ageing in the 'world's greatest athletes'.

PubMed

Careau, Vincent; Wilson, Robbie S

2017-08-16

The mechanistic foundations of performance trade-offs are clear: because body size and shape constrains movement, and muscles vary in strength and fibre type, certain physical traits should act in opposition with others (e.g. sprint versus endurance). Yet performance trade-offs are rarely detected, and traits are often positively correlated. A potential resolution to this conundrum is that within -individual performance trade-offs can be masked by among -individual variation in 'quality'. Although there is a current debate on how to unambiguously define and account for quality, no previous studies have partitioned trait correlations at the within- and among-individual levels. Here, we evaluate performance trade-offs among and within 1369 elite athletes that performed in a total of 6418 combined-events competitions (decathlon and heptathlon). Controlling for age, experience and wind conditions, we detected strong trade-offs between groups of functionally similar events (throwing versus jumping versus running) occurring at the among-individual level. We further modelled individual (co)variation in age-related plasticity of performance and found previously unseen trade-offs in throwing versus running performance that manifest through ageing. Our results verify that human performance is limited by fundamental genetic, environmental and ageing constraints that preclude the simultaneous improvement of performance in multiple dimensions. Identifying these constraints is fundamental to understanding performance trade-offs and predicting the ageing of motor function. © 2017 The Author(s).

Improved model for the design and analysis of centrifugal compressor volutes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Van den Braembussche, R.A.; Ayder, E.; Hagelstein, D.

1999-07-01

This paper describes a new model for the analysis of the flow in volutes of centrifugal compressors. It explicitly takes into account the vortical structure of the flow that has been observed during detailed three-dimensional flow measurements. It makes use of an impeller and diffuser response model to predict the nonuniformity of the volute inlet flow due, to the circumferential variation of the pressure at the volute inlet, and is therefore applicable also at off-design operation of the volute. Predicted total pressure loss and static pressure rise coefficients at design and off-design operation have been compared with experimental data formore » different volute geometries but only one test case is presented here. Good agreement in terms of losses and pressure rise is observed at most operating points and confirms the validity of the impeller and diffuser response model.« less

A computational approach for predicting off-target toxicity of antiviral ribonucleoside analogues to mitochondrial RNA polymerase.

PubMed

Freedman, Holly; Winter, Philip; Tuszynski, Jack; Tyrrell, D Lorne; Houghton, Michael

2018-06-22

In the development of antiviral drugs that target viral RNA-dependent RNA polymerases, off-target toxicity caused by the inhibition of the human mitochondrial RNA polymerase (POLRMT) is a major liability. Therefore, it is essential that all new ribonucleoside analogue drugs be accurately screened for POLRMT inhibition. A computational tool that can accurately predict NTP binding to POLRMT could assist in evaluating any potential toxicity and in designing possible salvaging strategies. Using the available crystal structure of POLRMT bound to an RNA transcript, here we created a model of POLRMT with an NTP molecule bound in the active site. Furthermore, we implemented a computational screening procedure that determines the relative binding free energy of an NTP analogue to POLRMT by free energy perturbation (FEP), i.e. a simulation in which the natural NTP molecule is slowly transformed into the analogue and back. In each direction, the transformation was performed over 40 ns of simulation on our IBM Blue Gene Q supercomputer. This procedure was validated across a panel of drugs for which experimental dissociation constants were available, showing that NTP relative binding free energies could be predicted to within 0.97 kcal/mol of the experimental values on average. These results demonstrate for the first time that free-energy simulation can be a useful tool for predicting binding affinities of NTP analogues to a polymerase. We expect that our model, together with similar models of viral polymerases, will be very useful in the screening and future design of NTP inhibitors of viral polymerases that have no mitochondrial toxicity. © 2018 Freedman et al.

ENGINEL: A single rotor turbojet engine cycle match performance program

NASA Technical Reports Server (NTRS)

Lovell, W. A.

1977-01-01

ENGINEL is a computer program which was developed to generate the design and off-design performance of a single rotor turbojet engine with or without afterburning using a cycle match procedure. It is capable of producing engine performance over a wide range of altitudes and Mach numbers. The flexibility, of operating with a variable geometry turbine, for improved off-design fuel consumption or with a fixed geometry turbine as in conventional turbojets, has been incorporated. In addition, the option of generation engine performance with JP4, liquid hydrogen or methane as fuel is provided.

Ares I Scale Model Acoustic Test Lift-Off Acoustics

NASA Technical Reports Server (NTRS)

Counter, Douglas D.; Houston, Janie D.

2011-01-01

The lift-off acoustic (LOA) environment is an important design factor for any launch vehicle. For the Ares I vehicle, the LOA environments were derived by scaling flight data from other launch vehicles. The Ares I LOA predicted environments are compared to the Ares I Scale Model Acoustic Test (ASMAT) preliminary results.

Macroscopic balance model for wave rotors

NASA Technical Reports Server (NTRS)

Welch, Gerard E.

1996-01-01

A mathematical model for multi-port wave rotors is described. The wave processes that effect energy exchange within the rotor passage are modeled using one-dimensional gas dynamics. Macroscopic mass and energy balances relate volume-averaged thermodynamic properties in the rotor passage control volume to the mass, momentum, and energy fluxes at the ports. Loss models account for entropy production in boundary layers and in separating flows caused by blade-blockage, incidence, and gradual opening and closing of rotor passages. The mathematical model provides a basis for predicting design-point wave rotor performance, port timing, and machine size. Model predictions are evaluated through comparisons with CFD calculations and three-port wave rotor experimental data. A four-port wave rotor design example is provided to demonstrate model applicability. The modeling approach is amenable to wave rotor optimization studies and rapid assessment of the trade-offs associated with integrating wave rotors into gas turbine engine systems.

Influence of Wind Model Performance on Wave Forecasts of the Naval Oceanographic Office

NASA Astrophysics Data System (ADS)

Gay, P. S.; Edwards, K. L.

2017-12-01

Significant discrepancies between the Naval Oceanographic Office's significant wave height (SWH) predictions and observations have been noted in some model domains. The goal of this study is to evaluate these discrepancies and identify to what extent inaccuracies in the wind predictions may explain inaccuracies in SWH predictions. A one-year time series of data is evaluated at various locations in Southern California and eastern Florida. Correlations are generally quite good, ranging from 73% at Pendleton to 88% at both Santa Barbara, California, and Cape Canaveral, Florida. Correlations for month-long periods off Southern California drop off significantly in late spring through early autumn - less so off eastern Florida - likely due to weaker local wind seas and generally smaller SWH in addition to the influence of remotely-generated swell, which may not propagate accurately into and through the wave models. The results of this study suggest that it is likely that a change in meteorological and/or oceanographic conditions explains the change in model performance, partially as a result of a seasonal reduction in wind model performance in the summer months.

Experimental Investigation of a Morphing Nacelle Ducted Fan

NASA Technical Reports Server (NTRS)

Kondor, Shayne A.; Moore, Mark

2005-01-01

The application of Circulation Control to the nacelle of a shrouded fan is proposed as a means to enhance off-design performance of the shrouded fan. Typically, a fixed geometry shroud is efficient at a single operating condition. Modifying circulation about the fixed geometry is proposed as a means to virtually morph the shroud without moving surfaces. This approach will enhance off-design-point performance with minimal complexity, weight, and cost. Termed the Morphing Nacelle, this concept provides an attractive propulsion option for Vertical Take-off and Landing (VTOL) aircraft, such conceptual Personal Air Vehicle (PAV) configurations proposed by NASA. An experimental proof of concept investigation of the Morphing Nacelle is detailed in this paper. A powered model shrouded fan model was constructed with Circulation Control (CC) devices integrated in the inlet and exit of the nacelle. Both CC devices consisted of an annular jet slot directing a jet sheet tangent to a curved surface, generally described as a Coanda surface. The model shroud was tailored for axial flight, with a diffusing inlet, but was operated off-design condition as a static lifting fan. Thrust stand experiments were conducted to determine if the CC devices could effectively improve off-design performance of the shrouded fan. Additional tests were conducted to explore the effectiveness of the CC devices a means to reduce peak static pressure on the ground below a lifting fan. Experimental results showed that off-design static thrust performance of the model was improved when the CC devices were employed under certain conditions. The exhaust CC device alone, while effective in diffusing the fan exhaust and improving weight flow into shroud inlet, tended to diminish performance of the fan with increased CC jet momentum. The inlet CC device was effective at reattaching a normally stalled inlet flow condition, proving an effective means of enhancing performance. A more dramatic improvement in static thrust was obtained when the inlet and exit CC devices were operated in unison, but only over a limited range of CC jet momentum. Operating the nacelle inlet and exit CC devices together proved very effective in reducing peak ground plane static pressure, while maintaining static thrust. The Morphing Nacelle concept proved effective at enhancing off-design performance of the model; however, additional investigation is necessary to generalize the results.

A theoretical approach to sound propagation and radiation for ducts with suppressors

NASA Technical Reports Server (NTRS)

Rice, E. J.; Sawdy, D. T.

1981-01-01

The several phenomena involved in theoretical prediction of the far-field sound radiation attenuation from an acoustically lined duct were studied. These include absorption by the suppressor, termination reflections, and far-field radiation. Extensive parametric studies show that the suppressor absorption performance can be correlated with mode cut-off ratio or angle of propagation. The other phenomena can be shown to depend explicitly upon mode cut-off ratio. A complete system can thus be generated which can be used to evaluate aircraft sound suppressors and which can be related to the sound source through the cut-off ratio-acoustic power distribution. Although the method is most fully developed for inlet suppressors, several aft radiated noise phenomena are also discussed. This simplified suppressor design and evaluation method is summarized, the recent improvements in the technique are presented, and areas where further refinement is necessary are discussed. Noise suppressor data from engine experiments are compared with the theoretical calculations.

Information Fusion for High Level Situation Assessment and Prediction

DTIC Science & Technology

2007-03-01

procedure includes deciding a sensor set that achieves the optimal trade -off between its cost and benefit, activating the identified sensors, integrating...and effective decision can be made by dynamic inference based on selecting a subset of sensors with the optimal trade -off between their cost and...first step is achieved by designing a sensor selection criterion that represents the trade -off between the sensor benefit and sensor cost. This is then

Characterization of off-gases from a small-scale, joule-heated ceramic melter for nuclear waste vitrification. [Ru, Cl, F, /sup 137/Cs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Woolsey, G.B.; Wilhite, E.L.

1980-01-01

This paper confirmed with actual nuclear waste the thermodynamic predictions of the fate of some of the semivolatiles in off-gas. Ruthenium behaves erratically and it is postulated that it migrates as a finely divided solid, rather than as a volatile oxide. Provisions for handling these waste off-gasses will be incorporated in the design of facilities for vitrifying SRP waste.

Design and Off-design Performance of 100 Kwe-class Brayton Power Conversion Systems

NASA Technical Reports Server (NTRS)

Johnson, Paul K.; Mason, Lee S.

2005-01-01

The NASA Glenn Research Center in-house computer model Closed Cycle Engine Program (CCEP) was used to explore the design trade space and off-design performance characteristics of 100 kWe-class recuperated Closed Brayton Cycle (CBC) power conversion systems. Input variables for a potential design point included the number of operating units (1, 2, 4), cycle peak pressure (0.5, 1, 2 MPa), and turbo-alternator shaft speed (30, 45, 60 kRPM). The design point analysis assumed a fixed turbine inlet temperature (1150 K), compressor inlet temperature (400 K), working-fluid molecular weight (40 g/mol), compressor pressure ratio (2.0), recuperator effectiveness (0.95), and a Sodium-Potassium (NaK) pumped-loop radiator. The design point options were compared on the basis of thermal input power, radiator area, and mass. For a nominal design point with defined Brayton components and radiator area, off-design cases were examined by reducing turbine inlet temperature (as low as 900 K), reducing shaft speed (as low as 50% of nominal), and circulating a percentage (up to 20%) of the compressor exit flow back to the gas cooler. The off-design examination sought approaches to reduce thermal input power without freezing the radiator.

The performance of Geiger mode avalanche photo-diodes in free space laser communication links

NASA Astrophysics Data System (ADS)

Farrell, Thomas C.

2018-05-01

Geiger mode avalanche photo-diode (APD) arrays, when used as detectors in laser communication (lasercom) receivers, promise better performance at lower signal levels than APDs operated in the linear mode. In this paper, we describe the basic operation of the Geiger mode APD array as a lasercom detector, concentrating on aspects relevant to the link design engineer (rather than, for example, describing the details of the physics of the basic device operation itself). Equations are developed that describe the effects of defocus and hold-off time on the relation between the number of photons detected by the array and the output of photo-electron counts. We show how to incorporate these equations into a link budget. The resulting predictions are validated by comparison against simulation results. Finally, we compare the performance of linear mode APD based receivers and Geiger mode APD array based receivers. Results show the Geiger mode receivers yield better performance, in terms of probability of bit error, at lower signal levels, except on links where there is an exceptionally large amount of background noise. Under those conditions, not surprisingly, the hold-off time degrades performance.

Risk mitigation process for utilization of commercial off-the-shelf (COTS) parts in CCD camera for military applications

NASA Astrophysics Data System (ADS)

Ahmad, Anees; Batcheldor, Scott; Cannon, Steven C.; Roberts, Thomas E.

2002-09-01

This paper presents the lessons learned during the design and development of a high performance cooled CCD camera for military applications utilizing common commercial off the shelf (COTS) parts. Our experience showed that concurrent evaluation and testing of high risk COTS must be performed to assess their performance over the required temperature range and other special product requirements such as fuel vapor compatibility, EMI and shock susceptibility, etc. Technical, cost and schedule risks for COTS parts must also be carefully evaluated. The customer must be involved in the selection and evaluation of such parts so that the performance limitations of the selected parts are clearly understood. It is equally important to check with vendors on the availability and obsolescence of the COTS parts being considered since the electronic components are often replaced by newer, better and cheaper models in a couple of years. In summary, this paper addresses the major benefits and risks associated with using commercial and industrial parts in military products, and suggests a risk mitigation approach to ensure a smooth development phase, and predictable performance from the end product.

Pulse Jet Mixing Tests With Noncohesive Solids

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meyer, Perry A.; Bamberger, Judith A.; Enderlin, Carl W.

2012-02-17

This report summarizes results from pulse jet mixing (PJM) tests with noncohesive solids in Newtonian liquid. The tests were conducted during FY 2007 and 2008 to support the design of mixing systems for the Hanford Waste Treatment and Immobilization Plant (WTP). Tests were conducted at three geometric scales using noncohesive simulants, and the test data were used to develop models predicting two measures of mixing performance for full-scale WTP vessels. The models predict the cloud height (the height to which solids will be lifted by the PJM action) and the critical suspension velocity (the minimum velocity needed to ensure allmore » solids are suspended off the floor, though not fully mixed). From the cloud height, the concentration of solids at the pump inlet can be estimated. The predicted critical suspension velocity for lifting all solids is not precisely the same as the mixing requirement for 'disturbing' a sufficient volume of solids, but the values will be similar and closely related. These predictive models were successfully benchmarked against larger scale tests and compared well with results from computational fluid dynamics simulations. The application of the models to assess mixing in WTP vessels is illustrated in examples for 13 distinct designs and selected operational conditions. The values selected for these examples are not final; thus, the estimates of performance should not be interpreted as final conclusions of design adequacy or inadequacy. However, this work does reveal that several vessels may require adjustments to design, operating features, or waste feed properties to ensure confidence in operation. The models described in this report will prove to be valuable engineering tools to evaluate options as designs are finalized for the WTP. Revision 1 refines data sets used for model development and summarizes models developed since the completion of Revision 0.« less

Advances in traction drive technology

NASA Technical Reports Server (NTRS)

Loewenthal, S. H.; Anderson, N. E.; Rohn, D. A.

1983-01-01

Traction drives are traced from early uses as main transmissions in automobiles at the turn of the century to modern, high-powered traction drives capable of transmitting hundreds of horsepower. Recent advances in technology are described which enable today's traction drive to be a serious candidate for off-highway vehicles and helicopter applications. Improvements in materials, traction fluids, design techniques, power loss and life prediction methods will be highlighted. Performance characteristics of the Nasvytis fixed-ratio drive are given. Promising future drive applications, such as helicopter main transmissions and servo-control positioning mechanisms are also addressed.

A progress report on the development of an augmentor wing jet STOL research aircraft.

NASA Technical Reports Server (NTRS)

Quigley, H. C.; Sinclair, S. R. M.; Nark, T. C., Jr.; O'Keefe, J. V.

1971-01-01

The development of the aircraft has progressed to the point where the design of the modifications to the de Havilland C-8A Buffalo is complete and the engines are being tested. The predicted performance shows that the aircraft will be able to take off and land in less than 1500 ft. Simulation studies indicate that the handling qualities of the aircraft, with stability augmentation, will be acceptable for STOL research missions. Special techniques were required, however, for flight path control and transition from cruise to landing configuration .

Computations in turbulent flows and off-design performance predictions for airframe-integrated scramjets

NASA Technical Reports Server (NTRS)

Goglia, G. L.; Spiegler, E.

1977-01-01

The research activity focused on two main tasks: (1) the further development of the SCRAM program and, in particular, the addition of a procedure for modeling the mechanism of the internal adjustment process of the flow, in response to the imposed thermal load across the combustor and (2) the development of a numerical code for the computation of the variation of concentrations throughout a turbulent field, where finite-rate reactions occur. The code also includes an estimation of the effect of the phenomenon called 'unmixedness'.

Alternative male morphs solve sperm performance/longevity trade-off in opposite directions.

PubMed

Taborsky, Michael; Schütz, Dolores; Goffinet, Olivier; van Doorn, G Sander

2018-05-01

Males pursuing alternative reproductive tactics have been predicted to face a trade-off between maximizing either swimming performance or endurance of their sperm. However, empirical evidence for this trade-off is equivocal, which may be due to simplistic assumptions. In the shell-brooding cichlid fish Lamprologus callipterus , two Mendelian male morphs compete for fertilization by divergent means: Bourgeois nest males ejaculate sperm, on average, about six times farther from the unfertilized ova than do parasitic dwarf males. This asymmetry is opposite to the usual situation, in which bourgeois males typically benefit from superior fertilization opportunities, suggesting that nest males' sperm should persist longer than dwarf male sperm. The assumed trade-off between sperm swimming performance and longevity predicts that, in turn, sperm of dwarf males should outperform that of nest males in swimming efficiency. Measurement of sperm performance and endurance reveals that dwarf male spermatozoa swim straighter initially than those of nest males, but their motility declines earlier and their velocity slows down more abruptly. Nest male sperm survives longer, which relates to a larger sperm head plus midpiece, implying more mitochondria. Thus, the trade-off between sperm performance and endurance is optimized in opposite directions by alternative male morphs. We argue that the relative success of alternative sperm performance strategies can be influenced strongly by environmental factors such as the time window between gamete release and fertilization, and the position of gamete release. This is an important yet little understood aspect of gametic adaptations to sperm competition.

VWPS: A Ventilator Weaning Prediction System with Artificial Intelligence

NASA Astrophysics Data System (ADS)

Chen, Austin H.; Chen, Guan-Ting

How to wean patients efficiently off mechanical ventilation continues to be a challenge for medical professionals. In this paper we have described a novel approach to the study of a ventilator weaning prediction system (VWPS). Firstly, we have developed and written three Artificial Neural Network (ANN) algorithms to predict a weaning successful rate based on the clinical data. Secondly, we have implemented two user-friendly weaning success rate prediction systems; the VWPS system and the BWAP system. Both systems could be used to help doctors objectively and effectively predict whether weaning is appropriate for patients based on the patients' clinical data. Our system utilizes the powerful processing abilities of MatLab. Thirdly, we have calculated the performance through measures such as sensitivity and accuracy for these three algorithms. The results show a very high sensitivity (around 80%) and accuracy (around 70%). To our knowledge, this is the first design approach of its kind to be used in the study of ventilator weaning success rate prediction.

Optimizing the stimulus presentation paradigm design for the P300-based brain-computer interface using performance prediction.

PubMed

Mainsah, B O; Reeves, G; Collins, L M; Throckmorton, C S

2017-08-01

The role of a brain-computer interface (BCI) is to discern a user's intended message or action by extracting and decoding relevant information from brain signals. Stimulus-driven BCIs, such as the P300 speller, rely on detecting event-related potentials (ERPs) in response to a user attending to relevant or target stimulus events. However, this process is error-prone because the ERPs are embedded in noisy electroencephalography (EEG) data, representing a fundamental problem in communication of the uncertainty in the information that is received during noisy transmission. A BCI can be modeled as a noisy communication system and an information-theoretic approach can be exploited to design a stimulus presentation paradigm to maximize the information content that is presented to the user. However, previous methods that focused on designing error-correcting codes failed to provide significant performance improvements due to underestimating the effects of psycho-physiological factors on the P300 ERP elicitation process and a limited ability to predict online performance with their proposed methods. Maximizing the information rate favors the selection of stimulus presentation patterns with increased target presentation frequency, which exacerbates refractory effects and negatively impacts performance within the context of an oddball paradigm. An information-theoretic approach that seeks to understand the fundamental trade-off between information rate and reliability is desirable. We developed a performance-based paradigm (PBP) by tuning specific parameters of the stimulus presentation paradigm to maximize performance while minimizing refractory effects. We used a probabilistic-based performance prediction method as an evaluation criterion to select a final configuration of the PBP. With our PBP, we demonstrate statistically significant improvements in online performance, both in accuracy and spelling rate, compared to the conventional row-column paradigm. By accounting for refractory effects, an information-theoretic approach can be exploited to significantly improve BCI performance across a wide range of performance levels.

Optimizing the stimulus presentation paradigm design for the P300-based brain-computer interface using performance prediction

NASA Astrophysics Data System (ADS)

Mainsah, B. O.; Reeves, G.; Collins, L. M.; Throckmorton, C. S.

2017-08-01

Objective. The role of a brain-computer interface (BCI) is to discern a user’s intended message or action by extracting and decoding relevant information from brain signals. Stimulus-driven BCIs, such as the P300 speller, rely on detecting event-related potentials (ERPs) in response to a user attending to relevant or target stimulus events. However, this process is error-prone because the ERPs are embedded in noisy electroencephalography (EEG) data, representing a fundamental problem in communication of the uncertainty in the information that is received during noisy transmission. A BCI can be modeled as a noisy communication system and an information-theoretic approach can be exploited to design a stimulus presentation paradigm to maximize the information content that is presented to the user. However, previous methods that focused on designing error-correcting codes failed to provide significant performance improvements due to underestimating the effects of psycho-physiological factors on the P300 ERP elicitation process and a limited ability to predict online performance with their proposed methods. Maximizing the information rate favors the selection of stimulus presentation patterns with increased target presentation frequency, which exacerbates refractory effects and negatively impacts performance within the context of an oddball paradigm. An information-theoretic approach that seeks to understand the fundamental trade-off between information rate and reliability is desirable. Approach. We developed a performance-based paradigm (PBP) by tuning specific parameters of the stimulus presentation paradigm to maximize performance while minimizing refractory effects. We used a probabilistic-based performance prediction method as an evaluation criterion to select a final configuration of the PBP. Main results. With our PBP, we demonstrate statistically significant improvements in online performance, both in accuracy and spelling rate, compared to the conventional row-column paradigm. Significance. By accounting for refractory effects, an information-theoretic approach can be exploited to significantly improve BCI performance across a wide range of performance levels.

Prediction of user preference over shared-control paradigms for a robotic wheelchair.

PubMed

Erdogan, Ahmetcan; Argall, Brenna D

2017-07-01

The design of intelligent powered wheelchairs has traditionally focused heavily on providing effective and efficient navigation assistance. Significantly less attention has been given to the end-user's preference between different assistance paradigms. It is possible to include these subjective evaluations in the design process, for example by soliciting feedback in post-experiment questionnaires. However, constantly querying the user for feedback during real-world operation is not practical. In this paper, we present a model that correlates objective performance metrics and subjective evaluations of autonomous wheelchair control paradigms. Using off-the-shelf machine learning techniques, we show that it is possible to build a model that can predict the most preferred shared-control method from task execution metrics such as effort, safety, performance and utilization. We further characterize the relative contributions of each of these metrics to the individual choice of most preferred assistance paradigm. Our evaluation includes Spinal Cord Injured (SCI) and uninjured subject groups. The results show that our proposed correlation model enables the continuous tracking of user preference and offers the possibility of autonomy that is customized to each user.

Engine isolation for structural-borne interior noise reduction in a general aviation aircraft

NASA Technical Reports Server (NTRS)

Unruh, J. F.; Scheidt, D. C.

1981-01-01

Engine vibration isolation for structural-borne interior noise reduction is investigated. A laboratory based test procedure to simulate engine induced structure-borne noise transmission, the testing of a range of candidate isolators for relative performance data, and the development of an analytical model of the transmission phenomena for isolator design evaluation are addressed. The isolator relative performance test data show that the elastomeric isolators do not appear to operate as single degree of freedom systems with respect to noise isolation. Noise isolation beyond 150 Hz levels off and begins to decrease somewhat above 600 Hz. Coupled analytical and empirical models were used to study the structure-borne noise transmission phenomena. Correlation of predicted results with measured data show that (1) the modeling procedures are reasonably accurate for isolator design evaluation, (2) the frequency dependent properties of the isolators must be included in the model if reasonably accurate noise prediction beyond 150 Hz is desired. The experimental and analytical studies were carried out in the frequency range from 10 Hz to 1000 Hz.

The trade-off between morphology and control in the co-optimized design of robots.

PubMed

Rosendo, Andre; von Atzigen, Marco; Iida, Fumiya

2017-01-01

Conventionally, robot morphologies are developed through simulations and calculations, and different control methods are applied afterwards. Assuming that simulations and predictions are simplified representations of our reality, how sure can roboticists be that the chosen morphology is the most adequate for the possible control choices in the real-world? Here we study the influence of the design parameters in the creation of a robot with a Bayesian morphology-control (MC) co-optimization process. A robot autonomously creates child robots from a set of possible design parameters and uses Bayesian Optimization (BO) to infer the best locomotion behavior from real world experiments. Then, we systematically change from an MC co-optimization to a control-only (C) optimization, which better represents the traditional way that robots are developed, to explore the trade-off between these two methods. We show that although C processes can greatly improve the behavior of poor morphologies, such agents are still outperformed by MC co-optimization results with as few as 25 iterations. Our findings, on one hand, suggest that BO should be used in the design process of robots for both morphological and control parameters to reach optimal performance, and on the other hand, point to the downfall of current design methods in face of new search techniques.

The trade-off between morphology and control in the co-optimized design of robots

PubMed Central

Iida, Fumiya

2017-01-01

Conventionally, robot morphologies are developed through simulations and calculations, and different control methods are applied afterwards. Assuming that simulations and predictions are simplified representations of our reality, how sure can roboticists be that the chosen morphology is the most adequate for the possible control choices in the real-world? Here we study the influence of the design parameters in the creation of a robot with a Bayesian morphology-control (MC) co-optimization process. A robot autonomously creates child robots from a set of possible design parameters and uses Bayesian Optimization (BO) to infer the best locomotion behavior from real world experiments. Then, we systematically change from an MC co-optimization to a control-only (C) optimization, which better represents the traditional way that robots are developed, to explore the trade-off between these two methods. We show that although C processes can greatly improve the behavior of poor morphologies, such agents are still outperformed by MC co-optimization results with as few as 25 iterations. Our findings, on one hand, suggest that BO should be used in the design process of robots for both morphological and control parameters to reach optimal performance, and on the other hand, point to the downfall of current design methods in face of new search techniques. PMID:29023482

Accuracy of SOFA score in prediction of 30-day outcome of critically ill patients.

PubMed

Safari, Saeed; Shojaee, Majid; Rahmati, Farhad; Barartloo, Alireza; Hahshemi, Behrooz; Forouzanfar, Mohammad Mehdi; Mohammadi, Elham

2016-12-01

Researchers have attempted to design various scoring systems to determine the severity and predict the outcome of critically ill patients. The present study aimed to evaluate the accuracy of SOFA score in predicting 1-month outcome of these patients in emergency department. The present study is a prospective cross-sectional study of >18 year old non-trauma critically ill patients presented to EDs of 3 hospitals, Tehran, Iran, during October 2014 to October 2015. Baseline characteristics, SOFA score variables, and 1-month outcome of patients were recorded and screening performance characteristics of the score were calculated using STATA 11 software. 140 patients with the mean age of 68.36 ± 18.62 years (18-95) were included (53.5% male). The most common complaints were decrease in level of consciousness (76.43%) and sepsis (60.0%), were the most frequent final diagnoses. Mean SOFA score of the patients was 7.13 ± 2.36 (minimum 2 and maximum 16). 72 (51.43%) patients died during the following 30 days and 16 (11.43%) patients were affected with multiple organ failure. Area under the ROC curve of SOFA score in predicting mortality of studied patients was 0.73 (95%CI: 0.65-0.81) (Fig. 2). Table 2 depicts screening performance characteristics of this scale in prediction of 1-month mortality in the best cut-off point of ≥7. At this cut-off point, sensitivity and specificity of SOFA in predicting 1-month mortality were 75% and 63.23%, respectively. Findings of the present study showed that SOFA scoring system has fair accuracy in predicting 1-month mortality of critically ill patients. However, until a more reliable scoring system is developed, SOFA might be useful for narrative prediction of patient outcome considering its acceptable likelihood ratios.

ATK Launch Vehicle (ALV-X1) Liftoff Acoustic Environments: Prediction vs. Measurement

NASA Technical Reports Server (NTRS)

Houston, J.; Counter, Douglas; Kenny, Jeremy; Murphy, John

2010-01-01

Launched from the Mid-Atlantic Regional Spaceport (MARS) Pad 01B on August 22, 2008, the ATK Launch Vehicle (ALV-X1) provided an opportunity to measure liftoff acoustic noise data. Predicted lift-off acoustic environments were developed by both NASA MSFC and ATK engineers. ATK engineers developed predictions for use in determining vibro-acoustic loads using the method described in the monograph NASA SP-8072. The MSFC ALV-X1 lift-off acoustic prediction was made with the Vehicle Acoustic Environment Prediction Program (VAEPP). The VAEPP and SP-8072 methods predict acoustic pressures of rocket systems generally scaled to existing rocket motor data based upon designed motor or engine characteristics. The predicted acoustic pressures are sound-pressure spectra at specific positions on the vehicle. This paper presents the measured liftoff acoustics on the vehicle and tower. This data is useful for the ALV-X1 in validating the pre-launch environments and loads predictions.

Development of the Second-Generation Oscillating Surge Wave Energy Converter with Variable Geometry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tom, Nathan M; Yu, Yi-Hsiang; Thresher, Robert W

This study investigates the effect of design changes on the hydrodynamics of a novel oscillating surge wave energy converter being developed at the National Renewable Energy Laboratory. The design utilizes controllable geometry features to shed structural loads while maintaining a rated power over a greater number of sea states. The second-generation design will seek to provide a more refined control of performance because the first-generation design demonstrated performance reductions considered too large for smooth power output. Performance is evaluated using frequency domain analysis with consideration of a nonideal power-take-off system, with respect to power absorption, foundation loads, and power-take-off torque.

Numerical simulation and experimental research on wake field of ships under off-design conditions

NASA Astrophysics Data System (ADS)

Guo, Chun-yu; Wu, Tie-cheng; Zhang, Qi; Gong, Jie

2016-10-01

Different operating conditions (e.g. design and off-design) may lead to a significant difference in the hydrodynamics performance of a ship, especially in the total resistance and wake field of ships. This work investigated the hydrodynamic performance of the well-known KRISO 3600 TEU Container Ship (KCS) under three different operating conditions by means of Particle Image Velocimetry (PIV) and Computational Fluid Dynamics (CFD). The comparison results show that the use of PIV to measure a ship's nominal wake field is an important method which has the advantages of being contactless and highly accurate. Acceptable agreements between the results obtained by the two different methods are achieved. Results indicate that the total resistances of the KCS model under two off-design conditions are 23.88% and 13.92% larger than that under the designed condition, respectively.

Video display engineering and optimization system

NASA Technical Reports Server (NTRS)

Larimer, James (Inventor)

1997-01-01

A video display engineering and optimization CAD simulation system for designing a LCD display integrates models of a display device circuit, electro-optics, surface geometry, and physiological optics to model the system performance of a display. This CAD system permits system performance and design trade-offs to be evaluated without constructing a physical prototype of the device. The systems includes a series of modules which permit analysis of design trade-offs in terms of their visual impact on a viewer looking at a display.

Drop-Off Detection with the Long Cane: Effects of Different Cane Techniques on Performance

ERIC Educational Resources Information Center

Kim, Dae Shik; Emerson, Robert Wall; Curtis, Amy

2009-01-01

This study compared the drop-off detection performance with the two-point touch and constant contact cane techniques using a repeated-measures design with a convenience sample of 15 cane users with visual impairments. The constant contact technique was superior to the two-point touch technique in the drop-off detection rate and the 50% detection…

A stochastic optimal feedforward and feedback control methodology for superagility

NASA Technical Reports Server (NTRS)

Halyo, Nesim; Direskeneli, Haldun; Taylor, Deborah B.

1992-01-01

A new control design methodology is developed: Stochastic Optimal Feedforward and Feedback Technology (SOFFT). Traditional design techniques optimize a single cost function (which expresses the design objectives) to obtain both the feedforward and feedback control laws. This approach places conflicting demands on the control law such as fast tracking versus noise atttenuation/disturbance rejection. In the SOFFT approach, two cost functions are defined. The feedforward control law is designed to optimize one cost function, the feedback optimizes the other. By separating the design objectives and decoupling the feedforward and feedback design processes, both objectives can be achieved fully. A new measure of command tracking performance, Z-plots, is also developed. By analyzing these plots at off-nominal conditions, the sensitivity or robustness of the system in tracking commands can be predicted. Z-plots provide an important tool for designing robust control systems. The Variable-Gain SOFFT methodology was used to design a flight control system for the F/A-18 aircraft. It is shown that SOFFT can be used to expand the operating regime and provide greater performance (flying/handling qualities) throughout the extended flight regime. This work was performed under the NASA SBIR program. ICS plans to market the software developed as a new module in its commercial CACSD software package: ACET.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Callahan, J.P.; Canonico, D.A.; Richardson, M.

The thermal cylinder experiment was designed both to provide information for evaluating the capability of analytical methods to predict the time-dependent stress-strain behavior of a /sup 1///sub 6/-scale model of the barrel section of a single-cavity prestressed concrete reactor vessel and to demonstrate the structural behavior under design and off-design thermal conditions. The model was a thick-walled cylinder having a height of 1.22 m, a thickness of 0.46 m, and an outer diameter of 2.06 m. It was prestressed both axially and circumferentially and subjected to 4.83 MPa internal pressure together with a thermal crossfall imposed by heating the innermore » surface to 338.8 K and cooling the outer surface to 297.1 K. The initial 460 days of testing were divided into time periods that simulated prestressing, heatup, reactor operation, and shutdown. At the conclusion of the simulated operating period, the model was repressurized and subjected to localized heating at 505.4 K for 84 days to produce an off-design hot-spot condition. Comparisons of experimental data with calculated values obtained using the SAFE-CRACK finite-element computer program showed that the program was capable of predicting time-dependent behavior in a vessel subjected to normal operating conditions, but that it was unable to accurately predict the behavior during off-design hot-spot heating. Readings made using a neutron and gamma-ray backscattering moisture probe showed little, if any, migration of moisture in the concrete cross section. Destructive examination indicated that the model maintained its basic structural integrity during localized hot-spot heating.« less

Designing Predictive Diagnose Method for Insulation Resistance Degradation of the Electrical Power Cables from Neutral Insulated Power Networks

NASA Astrophysics Data System (ADS)

Dobra, R.; Pasculescu, D.; Risteiu, M.; Buica, G.; Jevremović, V.

2017-06-01

This paper describe some possibilities to minimize voltages switching-off risks from the mining power networks, in case of insulated resistance faults by using a predictive diagnose method. The cables from the neutral insulated power networks (underground mining) are designed to provide a flexible electrical connection between portable or mobile equipment and a point of supply, including main feeder cable for continuous miners, pump cable, and power supply cable. An electronic protection for insulated resistance of mining power cables can be made using this predictive strategy. The main role of electronic relays for insulation resistance degradation of the electrical power cables, from neutral insulated power networks, is to provide a permanent measurement of the insulated resistance between phases and ground, in order to switch-off voltage when the resistance value is below a standard value. The automat system of protection is able to signalize the failure and the human operator will be early informed about the switch-off power and will have time to take proper measures to fix the failure. This logic for fast and automat switch-off voltage without aprioristic announcement is suitable for the electrical installations, realizing so a protection against fires and explosion. It is presented an algorithm and an anticipative relay for insulated resistance control from three-phase low voltage installations with insulated neutral connection.

Adaptive Data-based Predictive Control for Short Take-off and Landing (STOL) Aircraft

NASA Technical Reports Server (NTRS)

Barlow, Jonathan Spencer; Acosta, Diana Michelle; Phan, Minh Q.

2010-01-01

Data-based Predictive Control is an emerging control method that stems from Model Predictive Control (MPC). MPC computes current control action based on a prediction of the system output a number of time steps into the future and is generally derived from a known model of the system. Data-based predictive control has the advantage of deriving predictive models and controller gains from input-output data. Thus, a controller can be designed from the outputs of complex simulation code or a physical system where no explicit model exists. If the output data happens to be corrupted by periodic disturbances, the designed controller will also have the built-in ability to reject these disturbances without the need to know them. When data-based predictive control is implemented online, it becomes a version of adaptive control. The characteristics of adaptive data-based predictive control are particularly appropriate for the control of nonlinear and time-varying systems, such as Short Take-off and Landing (STOL) aircraft. STOL is a capability of interest to NASA because conceptual Cruise Efficient Short Take-off and Landing (CESTOL) transport aircraft offer the ability to reduce congestion in the terminal area by utilizing existing shorter runways at airports, as well as to lower community noise by flying steep approach and climb-out patterns that reduce the noise footprint of the aircraft. In this study, adaptive data-based predictive control is implemented as an integrated flight-propulsion controller for the outer-loop control of a CESTOL-type aircraft. Results show that the controller successfully tracks velocity while attempting to maintain a constant flight path angle, using longitudinal command, thrust and flap setting as the control inputs.

Merlin: Computer-Aided Oligonucleotide Design for Large Scale Genome Engineering with MAGE.

PubMed

Quintin, Michael; Ma, Natalie J; Ahmed, Samir; Bhatia, Swapnil; Lewis, Aaron; Isaacs, Farren J; Densmore, Douglas

2016-06-17

Genome engineering technologies now enable precise manipulation of organism genotype, but can be limited in scalability by their design requirements. Here we describe Merlin ( http://merlincad.org ), an open-source web-based tool to assist biologists in designing experiments using multiplex automated genome engineering (MAGE). Merlin provides methods to generate pools of single-stranded DNA oligonucleotides (oligos) for MAGE experiments by performing free energy calculation and BLAST scoring on a sliding window spanning the targeted site. These oligos are designed not only to improve recombination efficiency, but also to minimize off-target interactions. The application further assists experiment planning by reporting predicted allelic replacement rates after multiple MAGE cycles, and enables rapid result validation by generating primer sequences for multiplexed allele-specific colony PCR. Here we describe the Merlin oligo and primer design procedures and validate their functionality compared to OptMAGE by eliminating seven AvrII restriction sites from the Escherichia coli genome.

Using Mason number to predict MR damper performance from limited test data

NASA Astrophysics Data System (ADS)

Becnel, Andrew C.; Wereley, Norman M.

2017-05-01

The Mason number can be used to produce a single master curve which relates MR fluid stress versus strain rate behavior across a wide range of shear rates, temperatures, and applied magnetic fields. As applications of MR fluid energy absorbers expand to a variety of industries and operating environments, Mason number analysis offers a path to designing devices with desired performance from a minimal set of preliminary test data. Temperature strongly affects the off-state viscosity of the fluid, as the passive viscous force drops considerably at higher temperatures. Yield stress is not similarly affected, and stays relatively constant with changing temperature. In this study, a small model-scale MR fluid rotary energy absorber is used to measure the temperature correction factor of a commercially-available MR fluid from LORD Corporation. This temperature correction factor is identified from shear stress vs. shear rate data collected at four different temperatures. Measurements of the MR fluid yield stress are also obtained and related to a standard empirical formula. From these two MR fluid properties - temperature-dependent viscosity and yield stress - the temperature-corrected Mason number is shown to predict the force vs. velocity performance of a full-scale rotary MR fluid energy absorber. This analysis technique expands the design space of MR devices to high shear rates and allows for comprehensive predictions of overall performance across a wide range of operating conditions from knowledge only of the yield stress vs. applied magnetic field and a temperature-dependent viscosity correction factor.

Modeling Improvements and Users Manual for Axial-flow Turbine Off-design Computer Code AXOD

NASA Technical Reports Server (NTRS)

Glassman, Arthur J.

1994-01-01

An axial-flow turbine off-design performance computer code used for preliminary studies of gas turbine systems was modified and calibrated based on the experimental performance of large aircraft-type turbines. The flow- and loss-model modifications and calibrations are presented in this report. Comparisons are made between computed performances and experimental data for seven turbines over wide ranges of speed and pressure ratio. This report also serves as the users manual for the revised code, which is named AXOD.

Rotorcraft flight control design using quantitative feedback theory and dynamic crossfeeds

NASA Technical Reports Server (NTRS)

Cheng, Rendy P.

1995-01-01

A multi-input, multi-output controls design with robust crossfeeds is presented for a rotorcraft in near-hovering flight using quantitative feedback theory (QFT). Decoupling criteria are developed for dynamic crossfeed design and implementation. Frequency dependent performance metrics focusing on piloted flight are developed and tested on 23 flight configurations. The metrics show that the resulting design is superior to alternative control system designs using conventional fixed-gain crossfeeds and to feedback-only designs which rely on high gains to suppress undesired off-axis responses. The use of dynamic, robust crossfeeds prior to the QFT design reduces the magnitude of required feedback gain and results in performance that meets current handling qualities specifications relative to the decoupling of off-axis responses. The combined effect of the QFT feedback design following the implementation of low-order, dynamic crossfeed compensator successfully decouples ten of twelve off-axis channels. For the other two channels it was not possible to find a single, low-order crossfeed that was effective.

Design and Off-Design Performance of 100 kWe-Class Brayton Power Conversion Systems

NASA Technical Reports Server (NTRS)

Johnson, Paul K.; Mason, Lee S.

2005-01-01

The NASA Glenn Research Center in-house computer model Closed Cycle Engine Program (CCEP) was used to explore the design trade space and off-design performance characteristics of 100 kWe-class recuperated Closed Brayton Cycle (CBC) power conversion systems. Input variables for a potential design point included the number of operating units (1, 2, 4), cycle peak pressure (0.5, 1, 2 MPa), and turbo-alternator shaft speed (30, 45, 60 kRPM). The design point analysis assumed a fixed turbine inlet temperature (1150 K), compressor inlet temperature (400 K), helium-xenon working-fluid molecular weight (40 g/mol), compressor pressure ratio (2.0), recuperator effectiveness (0.95), and a Sodium-Potassium (NaK) pumped-loop radiator. The design point options were compared on the basis of thermal input power, radiator area, and mass. For a nominal design point with defined Brayton components and radiator area, off-design cases were examined by reducing turbine inlet temperature (as low as 900 K), reducing shaft speed (as low as 50 percent of nominal), and circulating a percentage (up to 20 percent) of the compressor exit flow back to the gas cooler. The off-design examination sought approaches to reduce thermal input power without freezing the radiator.

Design and Off-Design Performance of 100 kWe-Class Brayton Power Conversion Systems

NASA Astrophysics Data System (ADS)

Johnson, Paul K.; Mason, Lee S.

2005-02-01

The NASA Glenn Research Center in-house computer model Closed Cycle Engine Program (CCEP) was used to explore the design trade space and off-design performance characteristics of 100 kWe-class recuperated Closed Brayton Cycle (CBC) power conversion systems. Input variables for a potential design point included the number of operating units (1, 2, 4), cycle peak pressure (0.5, 1, 2 MPa), and turbo-alternator shaft speed (30,45, 60 kRPM). The design point analysis assumed a fixed turbine inlet temperature (1150 K), compressor inlet temperature (400 K), helium-xenon working-fluid molecular weight (40 g/mol), compressor pressure ratio (2.0), recuperator effectiveness (0.95), and a Sodium-Potassium (NaK) pumped-loop radiator. The design point options were compared on the basis of thermal input power, radiator area, and mass. For a nominal design point with defined Brayton components and radiator area, off-design cases were examined by reducing turbine inlet temperature (as low as 900 K), reducing shaft speed (as low as 50% of nominal), and circulating a percentage (up to 20%) of the compressor exit flow back to the gas cooler. The off-design examination sought approaches to reduce thermal input power without freezing the radiator.

Application of the Tool for Turbine Engine Closed-Loop Transient Analysis (TTECTrA) for Dynamic Systems Analysis

NASA Technical Reports Server (NTRS)

Csank, Jeffrey T.; Zinnecker, Alicia M.

2014-01-01

The aircraft engine design process seeks to achieve the best overall system-level performance, weight, and cost for a given engine design. This is achieved by a complex process known as systems analysis, where steady-state simulations are used to identify trade-offs that should be balanced to optimize the system. The steady-state simulations and data on which systems analysis relies may not adequately capture the true performance trade-offs that exist during transient operation. Dynamic Systems Analysis provides the capability for assessing these trade-offs at an earlier stage of the engine design process. The concept of dynamic systems analysis and the type of information available from this analysis are presented in this paper. To provide this capability, the Tool for Turbine Engine Closed-loop Transient Analysis (TTECTrA) was developed. This tool aids a user in the design of a power management controller to regulate thrust, and a transient limiter to protect the engine model from surge at a single flight condition (defined by an altitude and Mach number). Results from simulation of the closed-loop system may be used to estimate the dynamic performance of the model. This enables evaluation of the trade-off between performance and operability, or safety, in the engine, which could not be done with steady-state data alone. A design study is presented to compare the dynamic performance of two different engine models integrated with the TTECTrA software.

Off-Design Performance of a Streamline-Traced, External-Compression Supersonic Inlet

NASA Technical Reports Server (NTRS)

Slater, John W.

2017-01-01

A computational study was performed to explore the aerodynamic performance of a streamline-traced, external-compression inlet designed for Mach 1.664 at off-design conditions of freestream Mach number, angle-of-attack, and angle-of-sideslip. Serious degradation of the inlet performance occurred for negative angles-of-attack and angles-of-sideslip greater than 3 degrees. At low subsonic speeds, the swept leading edges of the inlet created a pair of vortices that propagated to the engine face. Increasing the bluntness of the cowl lip showed no real improvement in the inlet performance at the low speeds, but did improve the inlet performance at the design conditions. Reducing the inlet flow rate improved the inlet performance, but at the likely expense of reduced thrust of the propulsion system. Deforming the cowl lip for low-speed operation of the inlet increased the inlet capture area and improved the inlet performance.

Predicting fitness-to-drive following stroke using the Occupational Therapy - Driver Off Road Assessment Battery.

PubMed

Unsworth, Carolyn A; Baker, Anne; Lannin, Natasha; Harries, Priscilla; Strahan, Janene; Browne, Matthew

2018-02-28

It is difficult to determine if, or when, individuals with stroke are ready to undergo on-road fitness-to-drive assessment. The Occupational Therapy - Driver Off Road Assessment Battery was developed to determine client suitability to resume driving. The predictive validity of the Battery needs to be verified for people with stroke. Examine the predictive validity of the Occupational Therapy - Driver Off Road Assessment Battery for on-road performance among people with stroke. Off-road data were collected from 148 people post stroke on the Battery and the outcome of their on-road assessment was recorded as: fit-to-drive or not fit-to-drive. The majority of participants (76%) were able to resume driving. A classification and regression tree (CART) analysis using four subtests (three cognitive and one physical) from the Battery demonstrated an area under the curve (AUC) of 0.8311. Using a threshold of 0.5, the model correctly predicted 98/112 fit-to-drive (87.5%) and 26/36 people not fit-to-drive (72.2%). The three cognitive subtests from the Occupational Therapy - Driver Off Road Assessment Battery and potentially one of the physical tests have good predictive validity for client fitness-to-drive. These tests can be used to screen client suitability for proceeding to an on-road test following stroke. Implications for Rehabilitation: Following stroke, drivers should be counseled (including consideration of local legislation) concerning return to driving. The Occupational Therapy - Driver Off Road Assessment Battery can be used in the clinic to screen people for suitability to undertake on road assessment. Scores on four of the Occupational Therapy - Driver Off Road Assessment Battery subtests are predictive of resumption of driving following stroke.

Predicting Cost/Performance Trade-Offs for Whitney: A Commodity Computing Cluster

NASA Technical Reports Server (NTRS)

Becker, Jeffrey C.; Nitzberg, Bill; VanderWijngaart, Rob F.; Kutler, Paul (Technical Monitor)

1997-01-01

Recent advances in low-end processor and network technology have made it possible to build a "supercomputer" out of commodity components. We develop simple models of the NAS Parallel Benchmarks version 2 (NPB 2) to explore the cost/performance trade-offs involved in building a balanced parallel computer supporting a scientific workload. We develop closed form expressions detailing the number and size of messages sent by each benchmark. Coupling these with measured single processor performance, network latency, and network bandwidth, our models predict benchmark performance to within 30%. A comparison based on total system cost reveals that current commodity technology (200 MHz Pentium Pros with 100baseT Ethernet) is well balanced for the NPBs up to a total system cost of around $1,000,000.

Comparative analysis of anthropometric indices of obesity as correlates and potential predictors of risk for hypertension and prehypertension in a population in Nigeria.

PubMed

Ononamadu, Chimaobi James; Ezekwesili, Chinwe Nonyelum; Onyeukwu, Onyemaechi Faith; Umeoguaju, Uchenna Francis; Ezeigwe, Obiajulu Christian; Ihegboro, Godwin Okwudiri

Obesity is a well-established independent risk factor for hypertension and other cardiometabolic disorders. However, the best anthropometric index of obesity that predicts or associates strongly with hypertension and related conditions remains controversial and inconclusive. This study compared the performance of eight anthropometric indices of obesity: body mass index (BMI), ponderal index (PI), waist circumference (WC), hip circumference (HC), waist-hip ratio (WHR), waist-height ratio (WHtR), body adiposity index (BAI) and conicity index (CI) as correlates and potential predictors of risk of hypertension and prehypertension in a Nigerian population, and also the possible effect of combining two or more indices in that regard. This church-based, cross-sectional study was conducted in Anambra state, south-eastern Nigeria from 2012 to 2013. A total of 912 persons (436 male and 476 female) drawn randomly from three major cities (Awka, Onitsha and Nnewi) in the state participated in the study. Information on demography, medical history and lifestyle were obtained using a well-structured and validated questionnaire. The systolic/diastolic blood pressure and anthropometric measurements were taken by well-trained personnel. The resulting data were analysed using descriptive statistics, logistic regression, Poisson regression and receiver operating characteristic curve analysis. The mean values of all the anthropometric indices studied increased from normotension, through prehypertension to hypertension in both genders. BMI, WC, HC and CI were significantly higher (p < 0.05) in females than males. All the anthropometric indices studied were significantly (p < 0.001 except for CI) correlated with systolic and diastolic blood pressure. BMI, WHtR, WC and PI (with higher correlation coefficients for blood pressure) showed the best potential to predict hypertension and prehypertension in the study: BMI (cut-off = 24.49, AUC = 0.698; cut-off = 23.62, AUC = 0.659), WHtR (cut-off = 0.55, AUC = 0.682; cut-off = 0.5, AUC = 0.636), WC (cut-off = 91.44, AUC = 0.692; cut-off = 82.55, AUC = 0.645), PI (cut-off = 14.45, AUC = 0.670; cut-off = 13.69, AUC = 0.639), in males; and BMI (cut-off = 24.44, AUC = 0.622; cut-off = 28.01, AUC = 0.609), WHtR (cut-off = 0.51, AUC = 0.624; cut-off = 0.6, AUC = 0.572), WC ( cut-off = 96.62, AUC = 0.616; cut-off = 96.52, AUC = 0.584), PI ( cut-off = 16.38, AUC = 0.619; cut-off = 17.65, AUC = 0.599), in females for hypertension and prehypertension, respectively. In predicting hypertension risk, WC and WHtR did not significantly improve the performance of BMI in the models when included using our decision rule. Overall, CI had a very poor discriminatory power for both conditions in this study. BMI, WHtR, WC and PI emerged the best predictors of hypertension risk, and BMI, WC and PI of prehypertension risk in this study. The combination of high-performing anthropometric indices in a model did not improve their performance. Therefore we recommend the simultaneous but independent use of BMI and either WC or WHtR for predicting hypertension, and BMI and WC for prehypertension risk, bearing in mind that both types of index (abdominal and general obesity) account for different forms of obesity.

Comparative analysis of anthropometric indices of obesity as correlates and potential predictors of risk for hypertension and prehypertension in a population in Nigeria

PubMed Central

Ononamadu, Chimaobi James; Ihegboro, Godwin Okwudiri; Ezekwesili, Chinwe Nonyelum; Onyeukwu, Onyemaechi Faith; Umeoguaju,, Uchenna Francis; Ezeigwe, Obiajulu Christian

2017-01-01

Summary Background: Obesity is a well-established independent risk factor for hypertension and other cardiometabolic disorders. However, the best anthropometric index of obesity that predicts or associates strongly with hypertension and related conditions remains controversial and inconclusive. Objective: This study compared the performance of eight anthropometric indices of obesity: body mass index (BMI), ponderal index (PI), waist circumference (WC), hip circumference (HC), waist–hip ratio (WHR), waist–height ratio (WHtR), body adiposity index (BAI) and conicity index (CI) as correlates and potential predictors of risk of hypertension and prehypertension in a Nigerian population, and also the possible effect of combining two or more indices in that regard. Methods: This church-based, cross-sectional study was conducted in Anambra state, south-eastern Nigeria from 2012 to 2013. A total of 912 persons (436 male and 476 female) drawn randomly from three major cities (Awka, Onitsha and Nnewi) in the state participated in the study. Information on demography, medical history and lifestyle were obtained using a well-structured and validated questionnaire. The systolic/diastolic blood pressure and anthropometric measurements were taken by well-trained personnel. The resulting data were analysed using descriptive statistics, logistic regression, Poisson regression and receiver operating characteristic curve analysis. Results: The mean values of all the anthropometric indices studied increased from normotension, through prehypertension to hypertension in both genders. BMI, WC, HC and CI were significantly higher (p < 0.05) in females than males. All the anthropometric indices studied were significantly (p < 0.001 except for CI) correlated with systolic and diastolic blood pressure. BMI, WHtR, WC and PI (with higher correlation coefficients for blood pressure) showed the best potential potential to predict hypertension and prehypertension in the study: BMI (cut-off = 24.49, AUC = 0.698; cut-off = 23.62, AUC = 0.659), WHtR (cut-off = 0.55, AUC = 0.682; cut-off = 0.5, AUC = 0.636), WC (cut-off = 91.44, AUC = 0.692; cut-off = 82.55, AUC = 0.645), PI (cut-off = 14.45, AUC = 0.670; cut-off = 13.69, AUC = 0.639), in males; and BMI (cut-off = 24.44, AUC = 0.622; cut-off = 28.01, AUC = 0.609), WHtR (cut-off = 0.51, AUC = 0.624; cut-off = 0.6, AUC = 0.572), WC (cut-off = 96.62, AUC = 0.616; cut-off = 96.52, AUC = 0.584), PI (cut-off = 16.38, AUC = 0.619; cut-off = 17.65, AUC = 0.599), in females for hypertension and prehypertension, respectively. In predicting hypertension risk, WC and WHtR did not significantly improve the performance of BMI in the models when included using our decision rule. Overall, CI had a very poor discriminatory power for both conditions in this study. Conclusion: BMI, WHtR, WC and PI emerged the best predictors of hypertension risk, and BMI, WC and PI of prehypertension risk in this study. The combination of high-performing anthropometric indices in a model did not improve their performance. Therefore we recommend the simultaneous but independent use of BMI and either WC or WHtR for predicting hypertension, and BMI and WC for prehypertension risk, bearing in mind that both types of index (abdominal and general obesity) account for different forms of obesity. PMID:27701484

Validation of EGSYS Score in Prediction of Cardiogenic Syncope

PubMed Central

Kariman, Hamid; Harati, Sepideh; Safari, Saeed; Baratloo, Alireza; Pishgahi, Mehdi

2015-01-01

Introduction. Evaluation of Guidelines in Syncope Study (EGSYS) is designed to differentiate between cardiac and noncardiac causes of syncope. The present study aimed to evaluate the accuracy of this predictive model. Methods. In this prospective cross-sectional study, screening performance characteristics of EGSYS-U (univariate) and EGSYS-M (multivariate) in prediction of cardiac syncope were calculated for syncope patients who were referred to the emergency department (ED). Results. 198 patients with mean age of 59.26 ± 19.5 years were evaluated (62.3% male). 115 (58.4%) patients were diagnosed with cardiac syncope. Area under the ROC curve was 0.818 (95% CI: 0.75–0.87) for EGSYS-U and 0.805 (CI 95%: 0.74–0.86) for EGSYS-M (p = 0.53). Best cut-off point for both models was ≥3. Sensitivity and specificity were 86.08% (95% CI: 78.09–91.59) and 68.29% (95% CI: 56.97–77.86) for EGSYS-U and 91.30% (95% CI: 84.20–95.52) and 57.32% (95% CI: 45.92–68.02) for EGSYS-M, respectively. Conclusion. The results of this study demonstrated the acceptable accuracy of EGSYS score in predicting cardiogenic causes of syncope at the ≥3 cut-off point. It seems that using this model in daily practice can help physicians select at risk patients and properly triage them. PMID:26649200

Sheet Membrane Spacesuit Water Membrane Evaporator Thermal Test

NASA Technical Reports Server (NTRS)

Trevino, Luis A.; Bue, Grant C.

2009-01-01

For future lunar extravehicular activities (EVA), one method under consideration for rejecting crew and electronics heat involves evaporating water through a hydrophobic, porous Teflon(Registered Trademark) membrane. A Spacesuit Water Membrane Evaporator (SWME) prototype using this membrane was successfully tested by Ungar and Thomas (2001) with predicted performance matching test data well. The above referenced work laid the foundation for the design of a compact sheet membrane SWME development unit for use in the Constellation System Spacesuit Element Portable Life Support System (Vogel and et. al., ICES 2008). Major design objectives included minimizing mass, volume, and manufacturing complexity while rejecting a minimum of 810 watts of heat from water flowing through the SWME at 91 kg/hr with an inlet temperature of 291K. The design meeting these objectives consisted of three concentric cylindrical water channels interlaced with four water vapor channels. Two units were manufactured for the purpose of investigating manufacturing techniques and performing thermal testing. The extensive thermal test measured SWME heat rejection as a function of water inlet temperatures, water flow-rates, water absolute pressures, water impurities, and water vapor back-pressures. This paper presents the test results and subsequent analysis, which includes a comparison of SWME heat rejection measurements to pretest predictions. In addition, test measurements were taken such that an analysis of the commercial-off-the-shelf vapor pressure control valve could be performed.

Development of the Second-Generation Oscillating Surge Wave Energy Converter with Variable Geometry: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tom, Nathan M; Yu, Yi-Hsiang; Thresher, Robert W

This study investigates the effect of design changes on the hydrodynamics of a novel oscillating surge wave energy converter being developed at the National Renewable Energy Laboratory. The design utilizes controllable geometry features to shed structural loads while maintaining a rated power over a greater number of sea states. The second-generation design will seek to provide a more refined control of performance because the first-generation design demonstrated performance reductions considered too large for smooth power output. Performance is evaluated using frequency domain analysis with consideration of a nonideal power-take-off system, with respect to power absorption, foundation loads, and power-take-off torque.

Experimental and Computational Investigation of a Translating-Throat Single-Expansion-Ramp Nozzle

NASA Technical Reports Server (NTRS)

Deere, Karen A.; Asbury, Scott C.

1999-01-01

An experimental and computational study was conducted on a high-speed, single-expansion-ramp nozzle (SERN) concept designed for efficient off-design performance. The translating-throat SERN concept adjusts the axial location of the throat to provide a variable expansion ratio and allow a more optimum jet exhaust expansion at various flight conditions in an effort to maximize nozzle performance. Three design points (throat locations) were investigated to simulate the operation of this concept at subsonic-transonic, low supersonic, and high supersonic flight conditions. The experimental study was conducted in the jet exit test facility at the Langley Research Center. Internal nozzle performance was obtained at nozzle pressure ratios (NPR's) up to 13 for six nozzles with design nozzle pressure ratios near 9, 42, and 102. Two expansion-ramp surfaces, one concave and one convex, were tested for each design point. Paint-oil flow and focusing schlieren flow visualization techniques were utilized to acquire additional flow data at selected NPR'S. The Navier-Stokes code, PAB3D, was used with a two-equation k-e turbulence model for the computational study. Nozzle performance characteristics were predicted at nozzle pressure ratios of 5, 9, and 13 for the concave ramp, low Mach number nozzle and at 10, 13, and 102 for the concave ramp, high Mach number nozzle.

Evaluation of Watershed-Scale Simulations of In-Stream Pesticide Concentrations from Off-Target Spray Drift.

PubMed

Winchell, Michael F; Pai, Naresh; Brayden, Benjamin H; Stone, Chris; Whatling, Paul; Hanzas, John P; Stryker, Jody J

2018-01-01

The estimation of pesticide concentrations in surface water bodies is a critical component of the environmental risk assessment process required by regulatory agencies in North America, the European Union, and elsewhere. Pesticide transport to surface waters via deposition from off-field spray drift can be an important route of potential contamination. The spatial orientation of treated fields relative to receiving water bodies make prediction of off-target pesticide spray drift deposition and resulting aquatic estimated environmental concentrations (EECs) challenging at the watershed scale. The variability in wind conditions further complicates the simulation of the environmental processes leading to pesticide spray drift contributions to surface water. This study investigates the use of the Soil Water Assessment Tool (SWAT) for predicting concentrations of malathion (O,O-deimethyl thiophosphate of diethyl mercaptosuccinate) in a flowing water body when exposure is a result of off-target spray drift, and assesses the model's performance using a parameterization typical of a screening-level regulatory assessment. Six SWAT parameterizations, each including incrementally more site-specific data, are then evaluated to quantify changes in model performance. Results indicate that the SWAT model is an appropriate tool for simulating watershed scale concentrations of pesticides resulting from off-target spray drift deposition. The model predictions are significantly more accurate when the inputs and assumptions accurately reflect application practices and environmental conditions. Inclusion of detailed wind data had the most significant impact on improving model-predicted EECs in comparison to observed concentrations. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

Improving the accuracy of protein stability predictions with multistate design using a variety of backbone ensembles.

PubMed

Davey, James A; Chica, Roberto A

2014-05-01

Multistate computational protein design (MSD) with backbone ensembles approximating conformational flexibility can predict higher quality sequences than single-state design with a single fixed backbone. However, it is currently unclear what characteristics of backbone ensembles are required for the accurate prediction of protein sequence stability. In this study, we aimed to improve the accuracy of protein stability predictions made with MSD by using a variety of backbone ensembles to recapitulate the experimentally measured stability of 85 Streptococcal protein G domain β1 sequences. Ensembles tested here include an NMR ensemble as well as those generated by molecular dynamics (MD) simulations, by Backrub motions, and by PertMin, a new method that we developed involving the perturbation of atomic coordinates followed by energy minimization. MSD with the PertMin ensembles resulted in the most accurate predictions by providing the highest number of stable sequences in the top 25, and by correctly binning sequences as stable or unstable with the highest success rate (≈90%) and the lowest number of false positives. The performance of PertMin ensembles is due to the fact that their members closely resemble the input crystal structure and have low potential energy. Conversely, the NMR ensemble as well as those generated by MD simulations at 500 or 1000 K reduced prediction accuracy due to their low structural similarity to the crystal structure. The ensembles tested herein thus represent on- or off-target models of the native protein fold and could be used in future studies to design for desired properties other than stability. Copyright © 2013 Wiley Periodicals, Inc.

Impact Test and Simulation of Energy Absorbing Concepts for Earth Entry Vehicles

NASA Technical Reports Server (NTRS)

Billings, Marcus D.; Fasanella, Edwin L.; Kellas, Sotiris

2001-01-01

Nonlinear dynamic finite element simulations have been performed to aid in the design of an energy absorbing concept for a highly reliable passive Earth Entry Vehicle (EEV) that will directly impact the Earth without a parachute. EEV's are designed to return materials from asteroids, comets, or planets for laboratory analysis on Earth. The EEV concept uses an energy absorbing cellular structure designed to contain and limit the acceleration of space exploration samples during Earth impact. The spherical shaped cellular structure is composed of solid hexagonal and pentagonal foam-filled cells with hybrid graphite- epoxy/Kevlar cell walls. Space samples fit inside a smaller sphere at the center of the EEV's cellular structure. Comparisons of analytical predictions using MSC,Dytran with test results obtained from impact tests performed at NASA Langley Research Center were made for three impact velocities ranging from 32 to 40 m/s. Acceleration and deformation results compared well with the test results. These finite element models will be useful for parametric studies of off-nominal impact conditions.

A computer simulation of the turbocharged turbo compounded diesel engine system: A description of the thermodynamic and heat transfer models

NASA Technical Reports Server (NTRS)

Assanis, D. N.; Ekchian, J. E.; Frank, R. M.; Heywood, J. B.

1985-01-01

A computer simulation of the turbocharged turbocompounded direct-injection diesel engine system was developed in order to study the performance characteristics of the total system as major design parameters and materials are varied. Quasi-steady flow models of the compressor, turbines, manifolds, intercooler, and ducting are coupled with a multicylinder reciprocator diesel model, where each cylinder undergoes the same thermodynamic cycle. The master cylinder model describes the reciprocator intake, compression, combustion and exhaust processes in sufficient detail to define the mass and energy transfers in each subsystem of the total engine system. Appropriate thermal loading models relate the heat flow through critical system components to material properties and design details. From this information, the simulation predicts the performance gains, and assesses the system design trade-offs which would result from the introduction of selected heat transfer reduction materials in key system components, over a range of operating conditions.

Preliminary Analysis of an Oscillating Surge Wave Energy Converter with Controlled Geometry: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tom, Nathan; Lawson, Michael; Yu, Yi-Hsiang

The aim of this paper is to present a novel wave energy converter device concept that is being developed at the National Renewable Energy Laboratory. The proposed concept combines an oscillating surge wave energy converter with active control surfaces. These active control surfaces allow for the device geometry to be altered, which leads to changes in the hydrodynamic properties. The device geometry will be controlled on a sea state time scale and combined with wave-to-wave power-take-off control to maximize power capture, increase capacity factor, and reduce design loads. The paper begins with a traditional linear frequency domain analysis of themore » device performance. Performance sensitivity to foil pitch angle, the number of activated foils, and foil cross section geometry is presented to illustrate the current design decisions; however, it is understood from previous studies that modeling of current oscillating wave energy converter designs requires the consideration of nonlinear hydrodynamics and viscous drag forces. In response, a nonlinear model is presented that highlights the shortcomings of the linear frequency domain analysis and increases the precision in predicted performance.« less

Supersonic Retropropulsion Flight Test Concepts

NASA Technical Reports Server (NTRS)

Post, Ethan A.; Dupzyk, Ian C.; Korzun, Ashley M.; Dyakonov, Artem A.; Tanimoto, Rebekah L.; Edquist, Karl T.

2011-01-01

NASA's Exploration Technology Development and Demonstration Program has proposed plans for a series of three sub-scale flight tests at Earth for supersonic retropropulsion, a candidate decelerator technology for future, high-mass Mars missions. The first flight test in this series is intended to be a proof-of-concept test, demonstrating successful initiation and operation of supersonic retropropulsion at conditions that replicate the relevant physics of the aerodynamic-propulsive interactions expected in flight. Five sub-scale flight test article concepts, each designed for launch on sounding rockets, have been developed in consideration of this proof-of-concept flight test. Commercial, off-the-shelf components are utilized as much as possible in each concept. The design merits of the concepts are compared along with their predicted performance for a baseline trajectory. The results of a packaging study and performance-based trade studies indicate that a sounding rocket is a viable launch platform for this proof-of-concept test of supersonic retropropulsion.

Comparative performance study of smart structure for thermal microactuators

NASA Astrophysics Data System (ADS)

Yahya, Zulkarnain; Johar, Muhammad Akmal

2017-04-01

Thermal microactuator is one of earliest types of microactuators. Typical thermal actuators are in the form of Bimorph and Chevron structures. A bimorph thermal actuator has a complex movement direction, in arc motion and thus it is not feasible in the most MEMS designs. While Chevron actuator has a tendency to produce an off-plane movement which lead to low precision in lateral movement. A new thermal actuator design in the form of serpentine structures shows promising feature to have better performances in terms of more predictive lateral movement with smaller off-plane displacement. In MEMS chip design, areas play a critical role as it will impact with the cost of the final product. In this study, four different structures of thermal actuator were simulated using ANSYS v15. Three different set of area sizes which are 240 µm x 1000 µm, 240 µm x 1500 µm and 240 µm x 2000 µm have been analyzed. All four structures were named as Serpentine01, Serpentine02, Bimorph and Chevron. The data with regards to temperature produced by the structure and z-axis directional deformation were collected and analyzed. This paper reported the investigation result of comparison between these three types of thermal actuator structures design with a given area. From all of the result obtained, it is shown that the area 240 µm x 1500 µm showed a well balance performance in term of huge deformations and low power consumption. The Serpentine01 structure produced 16.7 µm deformation at 4mA of current. The results shows the potential of Serpentine01 structure as a new candidate for thermal microactuator for MEMS applications.

Wind tunnel tests on two-dimensional air intakes at DRDC Valcartier

DTIC Science & Technology

2009-04-01

systems. Accurate experimental data on the performance parameters of ramjet air intakes at different angles of attack during on- and off- design operation...supersoniques en raison de leurs meilleures performances au point de vue portée et vitesse comparativement à la propulsion avec des propergols solides. RDDC...during on- and off- design operation are required in order to verify the accuracy of numerical models. However, the open literature survey revealed

Hayabusa Re-Entry: Trajectory Analysis and Observation Mission Design

NASA Technical Reports Server (NTRS)

Cassell, Alan M.; Winter, Michael W.; Allen, Gary A.; Grinstead, Jay H.; Antimisiaris, Manny E.; Albers, James; Jenniskens, Peter

2011-01-01

On June 13th, 2010, the Hayabusa sample return capsule successfully re-entered Earth s atmosphere over the Woomera Prohibited Area in southern Australia in its quest to return fragments from the asteroid 1998 SF36 Itokawa . The sample return capsule entered at a super-orbital velocity of 12.04 km/sec (inertial), making it the second fastest human-made object to traverse the atmosphere. The NASA DC-8 airborne observatory was utilized as an instrument platform to record the luminous portion of the sample return capsule re-entry (60 sec) with a variety of on-board spectroscopic imaging instruments. The predicted sample return capsule s entry state information at 200 km altitude was propagated through the atmosphere to generate aerothermodynamic and trajectory data used for initial observation flight path design and planning. The DC- 8 flight path was designed by considering safety, optimal sample return capsule viewing geometry and aircraft capabilities in concert with key aerothermodynamic events along the predicted trajectory. Subsequent entry state vector updates provided by the Deep Space Network team at NASA s Jet Propulsion Laboratory were analyzed after the planned trajectory correction maneuvers to further refine the DC-8 observation flight path. Primary and alternate observation flight paths were generated during the mission planning phase which required coordination with Australian authorities for pre-mission approval. The final observation flight path was chosen based upon trade-offs between optimal viewing requirements, ground based observer locations (to facilitate post-flight trajectory reconstruction), predicted weather in the Woomera Prohibited Area and constraints imposed by flight path filing deadlines. To facilitate sample return capsule tracking by the instrument operators, a series of two racetrack flight path patterns were performed prior to the observation leg so the instruments could be pointed towards the region in the star background where the sample return capsule was expected to become visible. An overview of the design methodologies and trade-offs used in the Hayabusa re-entry observation campaign are presented.

Numerical simulation of hydrodynamics in a pump-turbine at off-design operating conditions in turbine mode

NASA Astrophysics Data System (ADS)

Yan, J. P.; Seidel, U.; Koutnik, J.

2012-11-01

The hydrodynamics of a reduced-scaled model of a radial pump-turbine is investigated under off-design operating conditions, involving runaway and "S-shape" turbine brake curve at low positive discharge. It is a low specific speed pump-turbine machine of Francis type with 9 impeller blades and 20 stay vanes as well as 20 guide vanes. The computational domain includes the entire water passage from the spiral casing inlet to the draft tube outlet. Completely structured hexahedral meshes generated by the commercial software ANSYS-ICEM are employed. The unsteady incompressible simulations are performed using the commercial code ANSYS-CFX13. For turbulence modeling the standard k-ε model is applied. The numerical results at different operating points are compared to the experimental results. The predicted pressure amplitude is in good agreement with the experimental data and the amplitude of normal force on impeller is in reasonable range. The detailed analysis reveals the onset of the flow instabilities when the machine is brought from a regular operating condition to runaway and turbine break mode. Furthermore, the rotating stall phenomena are well captured at runaway condition as well as low discharge operating condition with one stall cell rotating inside and around the impeller with about 70% of its frequency. Moreover, the rotating stall is found to be the effect of rotating flow separations developed in several consecutive impeller channels which lead to their blockage. The reliable simulation of S-curve characteristics in pump-turbines is a basic requirement for design and optimization at off-design operating conditions.

2-D Circulation Control Airfoil Benchmark Experiments Intended for CFD Code Validation

NASA Technical Reports Server (NTRS)

Englar, Robert J.; Jones, Gregory S.; Allan, Brian G.; Lin, Johb C.

2009-01-01

A current NASA Research Announcement (NRA) project being conducted by Georgia Tech Research Institute (GTRI) personnel and NASA collaborators includes the development of Circulation Control (CC) blown airfoils to improve subsonic aircraft high-lift and cruise performance. The emphasis of this program is the development of CC active flow control concepts for both high-lift augmentation, drag control, and cruise efficiency. A collaboration in this project includes work by NASA research engineers, whereas CFD validation and flow physics experimental research are part of NASA s systematic approach to developing design and optimization tools for CC applications to fixed-wing aircraft. The design space for CESTOL type aircraft is focusing on geometries that depend on advanced flow control technologies that include Circulation Control aerodynamics. The ability to consistently predict advanced aircraft performance requires improvements in design tools to include these advanced concepts. Validation of these tools will be based on experimental methods applied to complex flows that go beyond conventional aircraft modeling techniques. This paper focuses on recent/ongoing benchmark high-lift experiments and CFD efforts intended to provide 2-D CFD validation data sets related to NASA s Cruise Efficient Short Take Off and Landing (CESTOL) study. Both the experimental data and related CFD predictions are discussed.

A Nomographic Methodology for Use in Performance Trade-Off Studies of Parabolic Dish Solar Power Modules

NASA Technical Reports Server (NTRS)

Selcuk, M. K.; Fujita, T.

1984-01-01

A simple graphical method was developed to undertake technical design trade-off studies for individual parabolic dish models comprising a two-axis tracking parabolic dish with a cavity receiver and power conversion assembly at the focal point. The results of these technical studies are then used in performing the techno-economic analyses required for determining appropriate subsystem sizing. Selected graphs that characterize the performance of subsystems within the module were arranged in the form of a nomogram that would enable an investigator to carry out several design trade-off studies. Key performance parameters encompassed in the nomogram include receiver losses, intercept factor, engine rating, and engine efficiency. Design and operation parameters such as concentrator size, receiver type (open or windowed aperture), receiver aperture size, operating temperature of the receiver and engine, engine partial load characteristics, concentrator slope error, and the type of reflector surface, are also included in the graphical solution. Cost considerations are not included.

The performance of an online osteoporosis detection system a sensitivity and specificity analysis.

PubMed

Chang, Shu Fang; Hong, Chin Ming; Yang, Rong Sen

2014-07-01

To develop an online system for the detection of osteoporosis risk and to test its accuracy. Osteoporosis is a silent killer; usually, there are no symptoms, such as pain, until bone erosion and fracture occur. The risks of osteoporosis have been underestimated and neglected; as a result, osteoporosis can be as dangerous as heart diseases and cancers that lead to a healthcare crisis. Cross-sectional study. The study participants were individuals presenting for routine health examinations at a medical centre in Taiwan from 2006-2007. Women over 30 years of age who underwent dual-energy X-ray absorptiometry scanning for measurement of bone mineral density were eligible for this study. The system for osteoporosis detection and health risk, which was developed in this study, was analysed. The findings indicated a high sensitivity of 75%, specificity of 75%, positive predictive value of 75% and negative predictive value of 75%. In addition, the online osteoporosis detective system had a higher predictive power (24·2% vs. 11%) and a similar cut-off point (33% vs. 27%) compared with the tool designed by the International Osteoporosis Foundation. The online system for detection of osteoporosis risk had excellent reliability and validity. It performed well in predicting osteoporosis and the cut-off point used for identifying the risk among women at risk of developing osteoporosis. Therefore, it is suitable for the Asian women and can help women achieve the goals of early detection and health promotion. Early detection is the only way to prevent osteoporosis. Professional nurses should apply effective technology to promote health care in community-dwelling people. © 2013 John Wiley & Sons Ltd.

Diagnostic performance and optimal cut-off scores of the Massachusetts youth screening instrument-second version in a sample of Swiss youths in welfare and juvenile justice institutions.

PubMed

Dölitzsch, Claudia; Leenarts, Laura E W; Schmeck, Klaus; Fegert, Jorg M; Grisso, Thomas; Schmid, Marc

2017-02-08

There is a growing consensus about the importance of mental health screening of youths in welfare and juvenile justice institutions. The Massachusetts Youth Screening Instrument-second version (MAYSI-2) was specifically designed, normed and validated to assist juvenile justice facilities in the United States of America (USA), in identifying youths with potential emotional or behavioral problems. However, it is not known if the USA norm-based cut-off scores can be used in Switzerland. Therefore, the primary purpose of the current study was to estimate the diagnostic performance and optimal cut-off scores of the MAYSI-2 in a sample of Swiss youths in welfare and juvenile justice institutions. As the sample was drawn from the French-, German- and Italian-speaking parts of Switzerland, the three languages were represented in the total sample of the current study and consequently we could estimate the diagnostic performance and the optimal cut-off scores of the MAYSI-2 for the language regions separately. The other main purpose of the current study was to identify potential gender differences in the diagnostic performance and optimal cut-off scores. Participants were 297 boys and 149 girls (mean age = 16.2, SD = 2.5) recruited from 64 youth welfare and juvenile justice institutions (drawn from the French-, German- and Italian-speaking parts of Switzerland). The MAYSI-2 was used to screen for mental health or behavioral problems that could require further evaluation. Psychiatric classification was based on the Schedule for Affective Disorders and Schizophrenia for School-Age Children, Present and Lifetime version (K-SADS-PL). The MAYSI-2 scores were submitted into Receiver-Operating Characteristic (ROC) analyses to estimate the diagnostic performance and optimal 'caution' cut-off scores of the MAYSI-2. The ROC analyses revealed that nearly all homotypic mappings of MAYSI-2 scales onto (cluster of) psychiatric disorders revealed above chance level accuracy. The optimal 'caution' cut-off scores derived from the ROC curve for predicting (cluster of) psychiatric disorders were, for several MAYSI-2 scales, comparable to the USA norm-based 'caution' cut-off scores. For some MAYSI-2 scales, however, higher optimal 'caution' cut-off scores were found. With adjusted optimal 'caution' cut-off scores, the MAYSI-2 screens potential emotional or behavioral problems well in a sample of Swiss youths in welfare and juvenile justice institutions. However, as for choosing the optimal 'caution' cut off score for the MAYSI-2, both language as well as gender seems to be of importance. The results of this study point to a compelling need to test the diagnostic performance and optimal 'caution' cut-off scores of the MAYSI-2 more elaborately in larger differentiated language samples in Europe.

Network-based de-noising improves prediction from microarray data.

PubMed

Kato, Tsuyoshi; Murata, Yukio; Miura, Koh; Asai, Kiyoshi; Horton, Paul B; Koji, Tsuda; Fujibuchi, Wataru

2006-03-20

Prediction of human cell response to anti-cancer drugs (compounds) from microarray data is a challenging problem, due to the noise properties of microarrays as well as the high variance of living cell responses to drugs. Hence there is a strong need for more practical and robust methods than standard methods for real-value prediction. We devised an extended version of the off-subspace noise-reduction (de-noising) method to incorporate heterogeneous network data such as sequence similarity or protein-protein interactions into a single framework. Using that method, we first de-noise the gene expression data for training and test data and also the drug-response data for training data. Then we predict the unknown responses of each drug from the de-noised input data. For ascertaining whether de-noising improves prediction or not, we carry out 12-fold cross-validation for assessment of the prediction performance. We use the Pearson's correlation coefficient between the true and predicted response values as the prediction performance. De-noising improves the prediction performance for 65% of drugs. Furthermore, we found that this noise reduction method is robust and effective even when a large amount of artificial noise is added to the input data. We found that our extended off-subspace noise-reduction method combining heterogeneous biological data is successful and quite useful to improve prediction of human cell cancer drug responses from microarray data.

OFF-DESIGN PERFORMANCE OF RADIAL INFLOW TURBINES

NASA Technical Reports Server (NTRS)

Wasserbauer, C. A.

1994-01-01

This program calculates off design performance of radial inflow turbines. The program uses a one dimensional solution of flow conditions through the turbine along the main streamline. The loss model accounts for stator, rotor, incidence, and exit losses. Program features include consideration of stator and rotor trailing edge blockage and computation of performance to limiting load. Stator loss (loss in kinetic energy across the stator) is proportional to the average kinetic energy in the blade row and is represented in the program by an equation which includes a stator loss coefficient determined from design point performance and then assumed to be constant for the off design calculations. Minimum incidence loss does not occur at zero incidence angle with respect to the rotor blade, but at some optimum flow angle. At high pressure ratios the level of rotor inlet velocity seemed to have an excessive influence on the loss. Using the component of velocity in the direction of the optimum flow angle gave better correlations with experimental results. Overall turbine geometry and design point values of efficiency, pressure ratio, and mass flow are needed as input information. The output includes performance and velocity diagram parameters for any number of given speeds over a range of turbine pressure ratio. The program has been implemented on the IBM 7094 and operates in batch mode.

Compliance by Design: Influence of Acceleration Trade-offs on CO2 Emissions and Costs of Fuel Economy and Greenhouse Gas Regulations.

PubMed

Whitefoot, Kate S; Fowlie, Meredith L; Skerlos, Steven J

2017-09-19

The ability of automakers to improve the fuel economy of vehicles using engineering design modifications that compromise other performance attributes, such as acceleration, is not currently considered when setting fuel economy and greenhouse-gas emission standards for passenger cars and light trucks. We examine the role of these design trade-offs by simulating automaker responses to recently reformed vehicle standards with and without the ability to adjust acceleration performance. Results indicate that acceleration trade-offs can be important in two respects: (1) they can reduce the compliance costs of the standards, and (2) they can significantly reduce emissions associated with a particular level of the standards by mitigating incentives to shift sales toward larger vehicles and light trucks relative to passenger cars. We contrast simulation-based results with observed changes in vehicle attributes under the reformed standards. We find evidence that is consistent with firms using acceleration trade-offs to achieve compliance. Taken together, our analysis suggests that acceleration trade-offs play a role in automaker compliance strategies with potentially large implications for both compliance costs and emissions.

Four minutes of in-class high-intensity interval activity improves selective attention in 9- to 11-year olds.

PubMed

Ma, Jasmin K; Le Mare, Lucy; Gurd, Brendon J

2015-03-01

The amount of time allocated to physical activity in schools is declining. Time-efficient physical activity solutions that demonstrate their impact on academic achievement-related outcomes are needed to prioritize physical activity within the school curricula. "FUNtervals" are 4-min, high-intensity interval activities that use whole-body actions to complement a storyline. The purpose of this study was to (i) explore whether FUNtervals can improve selective attention, an executive function posited to be essential for learning and academic success; and (ii) examine whether this relationship is predicted by students' classroom off-task behaviour. Seven grade 3-5 classes (n = 88) were exposed to a single-group, repeated cross-over design where each student's selective attention was compared between no-activity and FUNtervals days. In week 1, students were familiarized with the d2 test of attention and FUNterval activities, and baseline off-task behaviour was observed. In both weeks 2 and 3 students completed the d2 test of attention following either a FUNterval break or a no-activity break. The order of these breaks was randomized and counterbalanced between weeks. Neither motor nor passive off-task behaviour predicted changes in selective attention following FUNtervals; however, a weak relationship was observed for verbal off-task behaviour and improvements in d2 test performance. More importantly, students made fewer errors during the d2 test following FUNtervals. In supporting the priority of physical activity inclusion within schools, FUNtervals, a time efficient and easily implemented physical activity break, can improve selective attention in 9- to 11-year olds.

ExaSAT: An exascale co-design tool for performance modeling

DOE PAGES

Unat, Didem; Chan, Cy; Zhang, Weiqun; ...

2015-02-09

One of the emerging challenges to designing HPC systems is understanding and projecting the requirements of exascale applications. In order to determine the performance consequences of different hardware designs, analytic models are essential because they can provide fast feedback to the co-design centers and chip designers without costly simulations. However, current attempts to analytically model program performance typically rely on the user manually specifying a performance model. Here we introduce the ExaSAT framework that automates the extraction of parameterized performance models directly from source code using compiler analysis. The parameterized analytic model enables quantitative evaluation of a broad range ofmore » hardware design trade-offs and software optimizations on a variety of different performance metrics, with a primary focus on data movement as a metric. Finally, we demonstrate the ExaSAT framework’s ability to perform deep code analysis of a proxy application from the Department of Energy Combustion Co-design Center to illustrate its value to the exascale co-design process. ExaSAT analysis provides insights into the hardware and software trade-offs and lays the groundwork for exploring a more targeted set of design points using cycle-accurate architectural simulators.« less

On the precision of aero-thermal simulations for TMT

NASA Astrophysics Data System (ADS)

Vogiatzis, Konstantinos; Thompson, Hugh

2016-08-01

Environmental effects on the Image Quality (IQ) of the Thirty Meter Telescope (TMT) are estimated by aero-thermal numerical simulations. These simulations utilize Computational Fluid Dynamics (CFD) to estimate, among others, thermal (dome and mirror) seeing as well as wind jitter and blur. As the design matures, guidance obtained from these numerical experiments can influence significant cost-performance trade-offs and even component survivability. The stochastic nature of environmental conditions results in the generation of a large computational solution matrix in order to statistically predict Observatory Performance. Moreover, the relative contribution of selected key subcomponents to IQ increases the parameter space and thus computational cost, while dictating a reduced prediction error bar. The current study presents the strategy followed to minimize prediction time and computational resources, the subsequent physical and numerical limitations and finally the approach to mitigate the issues experienced. In particular, the paper describes a mesh-independence study, the effect of interpolation of CFD results on the TMT IQ metric, and an analysis of the sensitivity of IQ to certain important heat sources and geometric features.

A Low Cost, Self Acting, Liquid Hydrogen Boil-Off Recovery System

NASA Technical Reports Server (NTRS)

Pelfrey, Joy W.; Sharp, Kirk V. (Technical Monitor)

2001-01-01

The purpose of this research was to develop a prototype liquid hydrogen boll-off recovery system. Perform analyses to finalize recovery system cycle, design detail components, fabricate hardware, and conduct sub-component, component, and system level tests leading to the delivery of a prototype system. The design point and off-design analyses identified cycle improvements to increase the robustness of the system by adding a by-pass heat exchanger. Based on the design, analysis, and testing conducted, the recovery system will liquefy 31% of the gaseous boil off from a liquid hydrogen storage tank. All components, including a high speed, miniature turbocompressor, were designed and manufacturing drawings were created. All hardware was fabricated and tests were conducted in air, helium, and hydrogen. Testing validated the design, except for the turbocompressor. A rotor-to-stator clearance issue was discovered as a result of a concentricity tolerance stack-up.

High-Fidelity Multi-Rotor Unmanned Aircraft System Simulation Development for Trajectory Prediction Under Off-Nominal Flight Dynamics

NASA Technical Reports Server (NTRS)

Foster, John V.; Hartman, David C.

2017-01-01

The NASA Unmanned Aircraft System (UAS) Traffic Management (UTM) project is conducting research to enable civilian low-altitude airspace and UAS operations. A goal of this project is to develop probabilistic methods to quantify risk during failures and off nominal flight conditions. An important part of this effort is the reliable prediction of feasible trajectories during off-nominal events such as control failure, atmospheric upsets, or navigation anomalies that can cause large deviations from the intended flight path or extreme vehicle upsets beyond the normal flight envelope. Few examples of high-fidelity modeling and prediction of off-nominal behavior for small UAS (sUAS) vehicles exist, and modeling requirements for accurately predicting flight dynamics for out-of-envelope or failure conditions are essentially undefined. In addition, the broad range of sUAS aircraft configurations already being fielded presents a significant modeling challenge, as these vehicles are often very different from one another and are likely to possess dramatically different flight dynamics and resultant trajectories and may require different modeling approaches to capture off-nominal behavior. NASA has undertaken an extensive research effort to define sUAS flight dynamics modeling requirements and develop preliminary high fidelity six degree-of-freedom (6-DOF) simulations capable of more closely predicting off-nominal flight dynamics and trajectories. This research has included a literature review of existing sUAS modeling and simulation work as well as development of experimental testing methods to measure and model key components of propulsion, airframe and control characteristics. The ultimate objective of these efforts is to develop tools to support UTM risk analyses and for the real-time prediction of off-nominal trajectories for use in the UTM Risk Assessment Framework (URAF). This paper focuses on modeling and simulation efforts for a generic quad-rotor configuration typical of many commercial vehicles in use today. An overview of relevant off-nominal multi-rotor behaviors will be presented to define modeling goals and to identify the prediction capability lacking in simplified models of multi-rotor performance. A description of recent NASA wind tunnel testing of multi-rotor propulsion and airframe components will be presented illustrating important experimental and data acquisition methods, and a description of preliminary propulsion and airframe models will be presented. Lastly, examples of predicted off-nominal flight dynamics and trajectories from the simulation will be presented.

Task-based lens design with application to digital mammography

NASA Astrophysics Data System (ADS)

Chen, Liying; Barrett, Harrison H.

2005-01-01

Recent advances in model observers that predict human perceptual performance now make it possible to optimize medical imaging systems for human task performance. We illustrate the procedure by considering the design of a lens for use in an optically coupled digital mammography system. The channelized Hotelling observer is used to model human performance, and the channels chosen are differences of Gaussians. The task performed by the model observer is detection of a lesion at a random but known location in a clustered lumpy background mimicking breast tissue. The entire system is simulated with a Monte Carlo application according to physics principles, and the main system component under study is the imaging lens that couples a fluorescent screen to a CCD detector. The signal-to-noise ratio (SNR) of the channelized Hotelling observer is used to quantify this detectability of the simulated lesion (signal) on the simulated mammographic background. Plots of channelized Hotelling SNR versus signal location for various lens apertures, various working distances, and various focusing places are presented. These plots thus illustrate the trade-off between coupling efficiency and blur in a task-based manner. In this way, the channelized Hotelling SNR is used as a merit function for lens design.

Task-based lens design, with application to digital mammography

NASA Astrophysics Data System (ADS)

Chen, Liying

Recent advances in model observers that predict human perceptual performance now make it possible to optimize medical imaging systems for human task performance. We illustrate the procedure by considering the design of a lens for use in an optically coupled digital mammography system. The channelized Hotelling observer is used to model human performance, and the channels chosen are differences of Gaussians (DOGs). The task performed by the model observer is detection of a lesion at a random but known location in a clustered lumpy background mimicking breast tissue. The entire system is simulated with a Monte Carlo application according to the physics principles, and the main system component under study is the imaging lens that couples a fluorescent screen to a CCD detector. The SNR of the channelized Hotelling observer is used to quantify the detectability of the simulated lesion (signal) upon the simulated mammographic background. In this work, plots of channelized Hotelling SNR vs. signal location for various lens apertures, various working distances, and various focusing places are shown. These plots thus illustrate the trade-off between coupling efficiency and blur in a task-based manner. In this way, the channelized Hotelling SNR is used as a merit function for lens design.

Evaluation of APRI and FIB-4 for noninvasive assessment of significant fibrosis and cirrhosis in HBeAg-negative CHB patients with ALT ≤ 2 ULN

PubMed Central

Li, Qiang; Ren, Xiaojing; Lu, Chuan; Li, Weixia; Huang, Yuxian; Chen, Liang

2017-01-01

Abstract To evaluate the performance of aspartate transaminase-to-platelet ratio index (APRI) and fibrosis index based on four factors (FIB-4) to predict significant fibrosis and cirrhosis in hepatitis B virus e antigen (HBeAg)-negative chronic hepatitis B (CHB) patients with alanine transaminase (ALT) ≤ twice the upper limit of normal (2 ULN). Histologic and laboratory data of 236 HBeAg-negative CHB patients with ALT ≤ 2 ULN were analyzed. Predicted fibrosis stage, based on established scales and cut-offs for APRI and FIB-4, was compared with METAVIR scores obtained from liver biopsy. In this study, the areas under the receiver operating characteristic curves (AUROCs) of APRI were lower than that of FIB-4 (0.62 vs 0.69; P = 0.019) for diagnosing significant fibrosis; however APRI and FIB-4 were comparable for diagnosing cirrhosis (0.77 vs 0.81; P = 0.374). When the cut-off proposed by WHO HBV guideline for APRI (>2.0) was used, no cirrhotic patients were correctly predicted. For FIB-4, the WHO proposed cut-off of 3.25 correctly identified significant fibrosis 83% of the time; but for APRI, the WHO proposed cut-off of 1.5 identified significant fibrosis 56%. In ruling out significant fibrosis, the WHO proposed APRI cut-off of 0.5 had a predictive value of 39%, and the FIB-4 cut-off of 1.45 correctly identified lack of significant fibrosis in 47% of the patients. In this study, based on ROC analysis, the optimal cut-offs were 0.46 and 0.65 for APRI, and 1.05 and 1.29 for FIB-4, for diagnosing significant fibrosis and cirrhosis, respectively. When the new cut-off of APRI (>0.65) was used, 82% of the cirrhotic patients were correctly predicted. In ruling out significant fibrosis, the new APRI cut-off (<0.46) had a predictive value of 80%, and new FIB-4 cut-off (<1.05) correctly identified lack of significant fibrosis in 84% of the patients. The WHO guidelines proposed cut-offs might be higher for HBeAg-negative CHB patients with ALT ≤2 ULN, and might underestimate the proportion of significant fibrosis and cirrhosis. A new set of cut-offs should be used to predict significant fibrosis and cirrhosis in this specific population. PMID:28328813

Evaluation of APRI and FIB-4 for noninvasive assessment of significant fibrosis and cirrhosis in HBeAg-negative CHB patients with ALT ≤ 2 ULN: A retrospective cohort study.

PubMed

Li, Qiang; Ren, Xiaojing; Lu, Chuan; Li, Weixia; Huang, Yuxian; Chen, Liang

2017-03-01

To evaluate the performance of aspartate transaminase-to-platelet ratio index (APRI) and fibrosis index based on four factors (FIB-4) to predict significant fibrosis and cirrhosis in hepatitis B virus e antigen (HBeAg)-negative chronic hepatitis B (CHB) patients with alanine transaminase (ALT) ≤ twice the upper limit of normal (2 ULN).Histologic and laboratory data of 236 HBeAg-negative CHB patients with ALT ≤ 2 ULN were analyzed. Predicted fibrosis stage, based on established scales and cut-offs for APRI and FIB-4, was compared with METAVIR scores obtained from liver biopsy.In this study, the areas under the receiver operating characteristic curves (AUROCs) of APRI were lower than that of FIB-4 (0.62 vs 0.69; P = 0.019) for diagnosing significant fibrosis; however APRI and FIB-4 were comparable for diagnosing cirrhosis (0.77 vs 0.81; P = 0.374). When the cut-off proposed by WHO HBV guideline for APRI (>2.0) was used, no cirrhotic patients were correctly predicted. For FIB-4, the WHO proposed cut-off of 3.25 correctly identified significant fibrosis 83% of the time; but for APRI, the WHO proposed cut-off of 1.5 identified significant fibrosis 56%. In ruling out significant fibrosis, the WHO proposed APRI cut-off of 0.5 had a predictive value of 39%, and the FIB-4 cut-off of 1.45 correctly identified lack of significant fibrosis in 47% of the patients. In this study, based on ROC analysis, the optimal cut-offs were 0.46 and 0.65 for APRI, and 1.05 and 1.29 for FIB-4, for diagnosing significant fibrosis and cirrhosis, respectively. When the new cut-off of APRI (>0.65) was used, 82% of the cirrhotic patients were correctly predicted. In ruling out significant fibrosis, the new APRI cut-off (<0.46) had a predictive value of 80%, and new FIB-4 cut-off (<1.05) correctly identified lack of significant fibrosis in 84% of the patients.The WHO guidelines proposed cut-offs might be higher for HBeAg-negative CHB patients with ALT ≤2 ULN, and might underestimate the proportion of significant fibrosis and cirrhosis. A new set of cut-offs should be used to predict significant fibrosis and cirrhosis in this specific population.

[Validation of cut points of skeletal muscle mass index for identifying sarcopenia in Chilean older people].

PubMed

Lera, Lydia; Ángel, Bárbara; Sánchez, Hugo; Picrin, Yaisy; Hormazabal, María José; Quiero, Andrea; Albala, Cecilia

2014-09-28

To estimate and validate cut-off points of skeletal muscle mass index (SMI) in Chilean population, for using in an algorithm for a diagnosis of sarcopenia developed by European Working Group on Sarcopenia in Older People (EWGSOP). Secondary analysis of Cross-sectional data in 440 Chilean older subjects to estimate cut-off points of SMI determined by DEXA and predicted by an anthropometric equation. Afterward a cross-sectional validation in a sample of 164 older people was performed. Anthropometric measures, self-reported health status, physical performance tests and DEXA were carried out. Decreased muscle strength was defined as handgrip strength <15 kg in women and <27 kg in male. Cut-off points of SMI were defined as values under 20th percentile for DEXA measures and estimated through ROC curves for the anthropometric model. Biological validity of the algorithm was tested by contrasting the diagnosis with physical performance tests and functionality. Cut-off points of SMI obtained by DEXA were 7.19 kg/m² in men and 5.77 kg/m² in women and 7.45 kg/ m² and 5.88 kg/m², respectively for the predicted by the model. Sensibility and specificity of estimations vs DEXA measures were 80% and 92% in men and 77% and 89% in women. We obtained cut-off points of SMI for DEXA and for a prediction equation for older adults Chilean, with good sensibility and specificity for the measurement by DEXA. It will allow to apply the EWGSOP algorithm to the early diagnosis of sarcopenia and to develop programs for prevention, delay or reversion this syndrome. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

Test and Analysis of Composite Hat Stringer Pull-off Test Specimens

NASA Technical Reports Server (NTRS)

Li, Jian; OBrien, T. Kevin; Rousseau, Carl Q.

1996-01-01

Hat stringer pull-off tests were performed to evaluate the delamination failure mechanisms in the flange region for a rod-reinforced hat stringer section. A special test fixture was used to pull the hat off the stringer while reacting the pull-off load through roller supports at both stringer flanges. Microscopic examinations of the failed specimens revealed that failure occurred at the ply termination in the flange area where the flange of the stiffener is built up by adding 45/-45 tape plies on the top surface. Test results indicated that the as-manufactured microstructure in the flange region has a strong influence on the delamination initiation and the associated pull-off loads. Finite element models were created for each specimen with a detailed mesh based on micrographs of the critical location. A fracture mechanics approach and a mixed mode delamination criterion were used to predict the onset of delamination and the pull-off load. By modeling the critical local details of each specimen from micrographs, the model was able to accurately predict the hat stringer pull-off loads and replicate the variability in the test results.

Measurement and Characterization of Space Shuttle Solid Rocket Motor Plume Acoustics

NASA Technical Reports Server (NTRS)

Kenny, Jeremy; Hobbs, Chris; Plotkin, Ken; Pilkey, Debbie

2009-01-01

Lift-off acoustic environments generated by the future Ares I launch vehicle are assessed by the NASA Marshall Space Flight Center (MSFC) acoustics team using several prediction tools. This acoustic environment is directly caused by the Ares I First Stage booster, powered by the five-segment Reusable Solid Rocket Motor (RSRMV). The RSRMV is a larger-thrust derivative design from the currently used Space Shuttle solid rocket motor, the Reusable Solid Rocket Motor (RSRM). Lift-off acoustics is an integral part of the composite launch vibration environment affecting the Ares launch vehicle and must be assessed to help generate hardware qualification levels and ensure structural integrity of the vehicle during launch and lift-off. Available prediction tools that use free field noise source spectrums as a starting point for generation of lift-off acoustic environments are described in the monograph NASA SP-8072: "Acoustic Loads Generated by the Propulsion System." This monograph uses a reference database for free field noise source spectrums which consist of subscale rocket motor firings, oriented in horizontal static configurations. The phrase "subscale" is appropriate, since the thrust levels of rockets in the reference database are orders of magnitude lower than the current design thrust for the Ares launch family. Thus, extrapolation is needed to extend the various reference curves to match Ares-scale acoustic levels. This extrapolation process yields a subsequent amount of uncertainty added upon the acoustic environment predictions. As the Ares launch vehicle design schedule progresses, it is important to take every opportunity to lower prediction uncertainty and subsequently increase prediction accuracy. Never before in NASA s history has plume acoustics been measured for large scale solid rocket motors. Approximately twice a year, the RSRM prime vendor, ATK Launch Systems, static fires an assembled RSRM motor in a horizontal configuration at their test facility in Utah. The remaining RSRM static firings will take place on elevated terrain, with the nozzle exit plume being mostly undeflected and the landscape allowing placement of microphones within direct line of sight to the exhaust plume. These measurements will help assess the current extrapolation process by direct comparison between subscale and full scale solid rocket motor data.

An Active Broad Area Cooling Model of a Cryogenic Propellant Tank with a Single Stage Reverse Turbo-Brayton Cycle Cryocooler

NASA Technical Reports Server (NTRS)

Guzik, Monica C.; Tomsik, Thomas M.

2011-01-01

As focus shifts towards long-duration space exploration missions, an increased interest in active thermal control of cryogenic propellants to achieve zero boil-off of cryogens has emerged. An active thermal control concept of considerable merit is the integration of a broad area cooling system for a cryogenic propellant tank with a combined cryocooler and circulator system that can be used to reduce or even eliminate liquid cryogen boil-off. One prospective cryocooler and circulator combination is the reverse turbo-Brayton cycle cryocooler. This system is unique in that it has the ability to both cool and circulate the coolant gas efficiently in the same loop as the broad area cooling lines, allowing for a single cooling gas loop, with the primary heat rejection occurring by way of a radiator and/or aftercooler. Currently few modeling tools exist that can size and characterize an integrated reverse turbo-Brayton cycle cryocooler in combination with a broad area cooling design. This paper addresses efforts to create such a tool to assist in gaining a broader understanding of these systems, and investigate their performance in potential space missions. The model uses conventional engineering and thermodynamic relationships to predict the preliminary design parameters, including input power requirements, pressure drops, flow rate, cycle performance, cooling lift, broad area cooler line sizing, and component operating temperatures and pressures given the cooling load operating temperature, heat rejection temperature, compressor inlet pressure, compressor rotational speed, and cryogenic tank geometry. In addition, the model allows for the preliminary design analysis of the broad area cooling tubing, to determine the effect of tube sizing on the reverse turbo-Brayton cycle system performance. At the time this paper was written, the model was verified to match existing theoretical documentation within a reasonable margin. While further experimental data is needed for full validation, this tool has already made significant steps towards giving a clearer understanding of the performance of a reverse turbo-Brayton cycle cryocooler integrated with broad area cooling technology for zero boil-off active thermal control.

Effect of Counterflow Jet on a Supersonic Reentry Capsule

NASA Technical Reports Server (NTRS)

Chang, Chau-Lyan; Venkatachari, Balaji Shankar; Cheng, Gary C.

2006-01-01

Recent NASA initiatives for space exploration have reinvigorated research on Apollo-like capsule vehicles. Aerothermodynamic characteristics of these capsule configurations during reentry play a crucial role in the performance and safety of the planetary entry probes and the crew exploration vehicles. At issue are the forebody thermal shield protection and afterbody aeroheating predictions. Due to the lack of flight or wind tunnel measurements at hypersonic speed, design decisions on such vehicles would rely heavily on computational results. Validation of current computational tools against experimental measurement thus becomes one of the most important tasks for general hypersonic research. This paper is focused on time-accurate numerical computations of hypersonic flows over a set of capsule configurations, which employ a counterflow jet to offset the detached bow shock. The accompanying increased shock stand-off distance and modified heat transfer characteristics associated with the counterflow jet may provide guidance for future design of hypersonic reentry capsules. The newly emerged space-time conservation element solution element (CESE) method is used to perform time-accurate, unstructured mesh Navier-Stokes computations for all cases investigated. The results show good agreement between experimental and numerical Schlieren pictures. Surface heat flux and aerodynamic force predictions of the capsule configurations are discussed in detail.

2B-Alert Web: An Open-Access Tool for Predicting the Effects of Sleep/Wake Schedules and Caffeine Consumption on Neurobehavioral Performance.

PubMed

Reifman, Jaques; Kumar, Kamal; Wesensten, Nancy J; Tountas, Nikolaos A; Balkin, Thomas J; Ramakrishnan, Sridhar

2016-12-01

Computational tools that predict the effects of daily sleep/wake amounts on neurobehavioral performance are critical components of fatigue management systems, allowing for the identification of periods during which individuals are at increased risk for performance errors. However, none of the existing computational tools is publicly available, and the commercially available tools do not account for the beneficial effects of caffeine on performance, limiting their practical utility. Here, we introduce 2B-Alert Web, an open-access tool for predicting neurobehavioral performance, which accounts for the effects of sleep/wake schedules, time of day, and caffeine consumption, while incorporating the latest scientific findings in sleep restriction, sleep extension, and recovery sleep. We combined our validated Unified Model of Performance and our validated caffeine model to form a single, integrated modeling framework instantiated as a Web-enabled tool. 2B-Alert Web allows users to input daily sleep/wake schedules and caffeine consumption (dosage and time) to obtain group-average predictions of neurobehavioral performance based on psychomotor vigilance tasks. 2B-Alert Web is accessible at: https://2b-alert-web.bhsai.org. The 2B-Alert Web tool allows users to obtain predictions for mean response time, mean reciprocal response time, and number of lapses. The graphing tool allows for simultaneous display of up to seven different sleep/wake and caffeine schedules. The schedules and corresponding predicted outputs can be saved as a Microsoft Excel file; the corresponding plots can be saved as an image file. The schedules and predictions are erased when the user logs off, thereby maintaining privacy and confidentiality. The publicly accessible 2B-Alert Web tool is available for operators, schedulers, and neurobehavioral scientists as well as the general public to determine the impact of any given sleep/wake schedule, caffeine consumption, and time of day on performance of a group of individuals. This evidence-based tool can be used as a decision aid to design effective work schedules, guide the design of future sleep restriction and caffeine studies, and increase public awareness of the effects of sleep amounts, time of day, and caffeine on alertness. © 2016 Associated Professional Sleep Societies, LLC.

Current versus future reproduction and longevity: a re-evaluation of predictions and mechanisms.

PubMed

Zhang, Yufeng; Hood, Wendy R

2016-10-15

Oxidative damage is predicted to be a mediator of trade-offs between current reproduction and future reproduction or survival, but most studies fail to support such predictions. We suggest that two factors underlie the equivocal nature of these findings: (1) investigators typically assume a negative linear relationship between current reproduction and future reproduction or survival, even though this is not consistently shown by empirical studies; and (2) studies often fail to target mechanisms that could link interactions between sequential life-history events. Here, we review common patterns of reproduction, focusing on the relationships between reproductive performance, survival and parity in females. Observations in a range of species show that performance between sequential reproductive events can decline, remain consistent or increase. We describe likely bioenergetic consequences of reproduction that could underlie these changes in fitness, including mechanisms that could be responsible for negative effects being ephemeral, persistent or delayed. Finally, we make recommendations for designing future studies. We encourage investigators to carefully consider additional or alternative measures of bioenergetic function in studies of life-history trade-offs. Such measures include reactive oxygen species production, oxidative repair, mitochondrial biogenesis, cell proliferation, mitochondrial DNA mutation and replication error and, importantly, a measure of the respiratory function to determine whether measured differences in bioenergetic state are associated with a change in the energetic capacity of tissues that could feasibly affect future reproduction or lifespan. More careful consideration of the life-history context and bioenergetic variables will improve our understanding of the mechanisms that underlie the life-history patterns of animals. © 2016. Published by The Company of Biologists Ltd.

Current versus future reproduction and longevity: a re-evaluation of predictions and mechanisms

PubMed Central

Zhang, Yufeng

2016-01-01

ABSTRACT Oxidative damage is predicted to be a mediator of trade-offs between current reproduction and future reproduction or survival, but most studies fail to support such predictions. We suggest that two factors underlie the equivocal nature of these findings: (1) investigators typically assume a negative linear relationship between current reproduction and future reproduction or survival, even though this is not consistently shown by empirical studies; and (2) studies often fail to target mechanisms that could link interactions between sequential life-history events. Here, we review common patterns of reproduction, focusing on the relationships between reproductive performance, survival and parity in females. Observations in a range of species show that performance between sequential reproductive events can decline, remain consistent or increase. We describe likely bioenergetic consequences of reproduction that could underlie these changes in fitness, including mechanisms that could be responsible for negative effects being ephemeral, persistent or delayed. Finally, we make recommendations for designing future studies. We encourage investigators to carefully consider additional or alternative measures of bioenergetic function in studies of life-history trade-offs. Such measures include reactive oxygen species production, oxidative repair, mitochondrial biogenesis, cell proliferation, mitochondrial DNA mutation and replication error and, importantly, a measure of the respiratory function to determine whether measured differences in bioenergetic state are associated with a change in the energetic capacity of tissues that could feasibly affect future reproduction or lifespan. More careful consideration of the life-history context and bioenergetic variables will improve our understanding of the mechanisms that underlie the life-history patterns of animals. PMID:27802148

Alternative evaluation metrics for risk adjustment methods.

PubMed

Park, Sungchul; Basu, Anirban

2018-06-01

Risk adjustment is instituted to counter risk selection by accurately equating payments with expected expenditures. Traditional risk-adjustment methods are designed to estimate accurate payments at the group level. However, this generates residual risks at the individual level, especially for high-expenditure individuals, thereby inducing health plans to avoid those with high residual risks. To identify an optimal risk-adjustment method, we perform a comprehensive comparison of prediction accuracies at the group level, at the tail distributions, and at the individual level across 19 estimators: 9 parametric regression, 7 machine learning, and 3 distributional estimators. Using the 2013-2014 MarketScan database, we find that no one estimator performs best in all prediction accuracies. Generally, machine learning and distribution-based estimators achieve higher group-level prediction accuracy than parametric regression estimators. However, parametric regression estimators show higher tail distribution prediction accuracy and individual-level prediction accuracy, especially at the tails of the distribution. This suggests that there is a trade-off in selecting an appropriate risk-adjustment method between estimating accurate payments at the group level and lower residual risks at the individual level. Our results indicate that an optimal method cannot be determined solely on the basis of statistical metrics but rather needs to account for simulating plans' risk selective behaviors. Copyright © 2018 John Wiley & Sons, Ltd.

Shape Optimization by Bayesian-Validated Computer-Simulation Surrogates

NASA Technical Reports Server (NTRS)

Patera, Anthony T.

1997-01-01

A nonparametric-validated, surrogate approach to optimization has been applied to the computational optimization of eddy-promoter heat exchangers and to the experimental optimization of a multielement airfoil. In addition to the baseline surrogate framework, a surrogate-Pareto framework has been applied to the two-criteria, eddy-promoter design problem. The Pareto analysis improves the predictability of the surrogate results, preserves generality, and provides a means to rapidly determine design trade-offs. Significant contributions have been made in the geometric description used for the eddy-promoter inclusions as well as to the surrogate framework itself. A level-set based, geometric description has been developed to define the shape of the eddy-promoter inclusions. The level-set technique allows for topology changes (from single-body,eddy-promoter configurations to two-body configurations) without requiring any additional logic. The continuity of the output responses for input variations that cross the boundary between topologies has been demonstrated. Input-output continuity is required for the straightforward application of surrogate techniques in which simplified, interpolative models are fitted through a construction set of data. The surrogate framework developed previously has been extended in a number of ways. First, the formulation for a general, two-output, two-performance metric problem is presented. Surrogates are constructed and validated for the outputs. The performance metrics can be functions of both outputs, as well as explicitly of the inputs, and serve to characterize the design preferences. By segregating the outputs and the performance metrics, an additional level of flexibility is provided to the designer. The validated outputs can be used in future design studies and the error estimates provided by the output validation step still apply, and require no additional appeals to the expensive analysis. Second, a candidate-based a posteriori error analysis capability has been developed which provides probabilistic error estimates on the true performance for a design randomly selected near the surrogate-predicted optimal design.

Experimental analysis of the flow in a two stage axial compressor at off-design conditions

NASA Astrophysics Data System (ADS)

Massardo, Aristide; Satta, Antonio

1987-05-01

The experimental analysis of the flow that develops in a two-stage axial flow compressor at off-design conditions is presented. The measurements are performed upstream, between, and downstream of the four blade rows of the compressor. The analysis shows the off-design effects on the local conditions of the flow field. Low-energy flow zones are identified, and the development of annulus-boundary-layer, secondary, and tip-clearance flows is shown. The tip-clearance flows are also present in the stator rows with various outlying conditions (stationary or rotating hub).

Low Boom Configuration Analysis with FUN3D Adjoint Simulation Framework

NASA Technical Reports Server (NTRS)

Park, Michael A.

2011-01-01

Off-body pressure, forces, and moments for the Gulfstream Low Boom Model are computed with a Reynolds Averaged Navier Stokes solver coupled with the Spalart-Allmaras (SA) turbulence model. This is the first application of viscous output-based adaptation to reduce estimated discretization errors in off-body pressure for a wing body configuration. The output adaptation approach is compared to an a priori grid adaptation technique designed to resolve the signature on the centerline by stretching and aligning the grid to the freestream Mach angle. The output-based approach produced good predictions of centerline and off-centerline measurements. Eddy viscosity predicted by the SA turbulence model increased significantly with grid adaptation. Computed lift as a function of drag compares well with wind tunnel measurements for positive lift, but predicted lift, drag, and pitching moment as a function of angle of attack has significant differences from the measured data. The sensitivity of longitudinal forces and moment to grid refinement is much smaller than the differences between the computed and measured data.

Off-Nominal Performance of the International Space Station Solar Array Wings Under Orbital Eclipse Lighting Scenarios

NASA Technical Reports Server (NTRS)

Kerslake, Thomas W.; Scheiman, David A.

2005-01-01

This paper documents testing and analyses to quantify International Space Station (ISS) Solar Array Wing (SAW) string electrical performance under highly off-nominal, low-temperature-low-intensity (LILT) operating conditions with nonsolar light sources. This work is relevant for assessing feasibility and risks associated with a Sequential Shunt Unit (SSU) remove and replace (R&R) Extravehicular Activity (EVA). During eclipse, SAW strings can be energized by moonlight, EVA suit helmet lights or video camera lights. To quantify SAW performance under these off-nominal conditions, solar cell performance testing was performed using full moon, solar simulator and Video Camera Luminaire (VCL) light sources. Test conditions included 25 to 110 C temperatures and 1- to 0.0001-Sun illumination intensities. Electrical performance data and calculated eclipse lighting intensities were combined to predict SAW current-voltage output for comparison with electrical hazard thresholds. Worst case predictions show there is no connector pin molten metal hazard but crew shock hazard limits are exceeded due to VCL illumination. Assessment uncertainties and limitations are discussed along with operational solutions to mitigate SAW electrical hazards from VCL illumination. Results from a preliminary assessment of SAW arcing are also discussed. The authors recommend further analyses once SSU, R&R, and EVA procedures are better defined.

Predicting posttraumatic stress disorder in children and parents following accidental child injury: evaluation of the Screening Tool for Early Predictors of Posttraumatic Stress Disorder (STEPP).

PubMed

van Meijel, Els P M; Gigengack, Maj R; Verlinden, Eva; Opmeer, Brent C; Heij, Hugo A; Goslings, J Carel; Bloemers, Frank W; Luitse, Jan S K; Boer, Frits; Grootenhuis, Martha A; Lindauer, Ramón J L

2015-05-12

Children and their parents are at risk of posttraumatic stress disorder (PTSD) following injury due to pediatric accidental trauma. Screening could help predict those at greatest risk and provide an opportunity for monitoring so that early intervention may be provided. The purpose of this study was to evaluate the Screening Tool for Early Predictors of Posttraumatic Stress Disorder (STEPP) in a mixed-trauma sample in a non-English speaking country (the Netherlands). Children aged 8-18 and one of their parents were recruited in two academic level I trauma centers. The STEPP was assessed in 161 children (mean age 13.9 years) and 156 parents within one week of the accident. Three months later, clinical diagnoses and symptoms of PTSD were assessed in 147 children and 135 parents. We used the Anxiety Disorders Interview Schedule for DSM-IV - Child and Parent version, the Children's Revised Impact of Event Scale and the Impact of Event Scale-Revised. Receiver Operating Characteristic analyses were performed to estimate the Areas Under the Curve as a measure of performance and to determine the optimal cut-off score in our sample. Sensitivity, specificity, positive and negative predictive values were calculated. The aim was to maximize both sensitivity and negative predictive values. PTSD was diagnosed in 12% of the children; 10% of their parents scored above the cut-off point for PTSD. At the originally recommended cut-off scores (4 for children, 3 for parents), the sensitivity in our sample was 41% for children and 54% for parents. Negative predictive values were 92% for both groups. Adjusting the cut-off scores to 2 improved sensitivity to 82% for children and 92% for parents, with negative predictive values of 92% and 96%, respectively. With adjusted cut-off scores, the STEPP performed well: 82% of the children and 92% of the parents with a subsequent positive diagnosis were identified correctly. Special attention in the screening procedure is required because of a high rate of false positives. The STEPP appears to be a valid and useful instrument that can be used in the Netherlands as a first screening method in stepped psychotrauma care following accidents.

Bike and run pacing on downhill segments predict Ironman triathlon relative success.

PubMed

Johnson, Evan C; Pryor, J Luke; Casa, Douglas J; Belval, Luke N; Vance, James S; DeMartini, Julie K; Maresh, Carl M; Armstrong, Lawrence E

2015-01-01

Determine if performance and physiological based pacing characteristics over the varied terrain of a triathlon predicted relative bike, run, and/or overall success. Poor self-regulation of intensity during long distance (Full Iron) triathlon can manifest in adverse discontinuities in performance. Observational study of a random sample of Ironman World Championship athletes. High performing and low performing groups were established upon race completion. Participants wore global positioning system and heart rate enabled watches during the race. Percentage difference from pre-race disclosed goal pace (%off) and mean HR were calculated for nine segments of the bike and 11 segments of the run. Normalized graded running pace (accounting for changes in elevation) was computed via analysis software. Step-wise regression analyses identified segments predictive of relative success and HP and LP were compared at these segments to confirm importance. %Off of goal velocity during two downhill segments of the bike (HP: -6.8±3.2%, -14.2±2.6% versus LP: -1.2±4.2%, -5.1±11.5%; p<0.020) and %off from NGP during one downhill segment of the run (HP: 4.8±5.2% versus LP: 33.3±38.7%; p=0.033) significantly predicted relative performance. Also, HP displayed more consistency in mean HR (141±12 to 138±11 bpm) compared to LP (139±17 to 131±16 bpm; p=0.019) over the climb and descent from the turn-around point during the bike component. Athletes who maintained faster relative speeds on downhill segments, and who had smaller changes in HR between consecutive up and downhill segments were more successful relative to their goal times. Copyright © 2013 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

Experimental evolution for generalists and specialists reveals multivariate genetic constraints on thermal reaction norms.

PubMed

Berger, D; Walters, R J; Blanckenhorn, W U

2014-09-01

Theory predicts the emergence of generalists in variable environments and antagonistic pleiotropy to favour specialists in constant environments, but empirical data seldom support such generalist-specialist trade-offs. We selected for generalists and specialists in the dung fly Sepsis punctum (Diptera: Sepsidae) under conditions that we predicted would reveal antagonistic pleiotropy and multivariate trade-offs underlying thermal reaction norms for juvenile development. We performed replicated laboratory evolution using four treatments: adaptation at a hot (31 °C) or a cold (15 °C) temperature, or under regimes fluctuating between these temperatures, either within or between generations. After 20 generations, we assessed parental effects and genetic responses of thermal reaction norms for three correlated life-history traits: size at maturity, juvenile growth rate and juvenile survival. We find evidence for antagonistic pleiotropy for performance at hot and cold temperatures, and a temperature-mediated trade-off between juvenile survival and size at maturity, suggesting that trade-offs associated with environmental tolerance can arise via intensified evolutionary compromises between genetically correlated traits. However, despite this antagonistic pleiotropy, we found no support for the evolution of increased thermal tolerance breadth at the expense of reduced maximal performance, suggesting low genetic variance in the generalist-specialist dimension. © 2014 The Authors. Journal of Evolutionary Biology © 2014 European Society For Evolutionary Biology.

The diagnostic utility of the Rarely Missed Index of the Wechsler Memory Scale-Third Edition in detecting response bias in an adult male incarcerated setting.

PubMed

D'Amato, Christopher P; Denney, Robert L

2008-09-01

The purpose of this study was to utilize a known-group research design to evaluate the diagnostic utility of the Rarely Missed Index (RMI) of the Wechsler Memory Scale-Third Edition [Wechsler, D. (1997). Wechsler Adult Intelligence Test-3rd Edition. San Antonio, TX: The Psychological Corporation] in assessing response bias in an adult male incarcerated setting. Archival data from a sample of 60 adult male inmates who presented for neuropsychological testing were reviewed. Evaluees were assigned to one of two groups; probable malingerers (PM; n=30) and a group of valid test responders (n=30) (1999). Using the recommended cut-off score of 136 or less, the sensitivity of the RMI was extremely low at 33%. Its specificity was 83%. The positive predictive power of the RMI with the published base rate of 22.8 was 38%; with a negative predictive power of 81%. The positive predictive power of the RMI with a published base rate of 70.5 was 82%. The negative predictive power using a base rate of 70.5% was 34%. Results of the receiver operating characteristics (ROC) analysis indicated that the RMI score with a cut-off 136 or less performed only slightly better than chance in delineating probable malingerers from valid responders in this setting. Overall, the findings suggest that the RMI may not be a reliable index for detecting response bias in this setting and perhaps in similar settings.

Computer programs for axial flow compressor design

NASA Technical Reports Server (NTRS)

Carmody, R. H.; Creveling, H. F.

1969-01-01

Four computer programs examine effects of design parameters and indicate areas for research of multistage axial flow compressors. The programs provide information on velocity diagrams and stage-by-stage performance calculation, radial equilibrium of flow, radial distribution of total pressure, and off-design performance calculation.

Financial Distress Prediction Using Discrete-time Hazard Model and Rating Transition Matrix Approach

NASA Astrophysics Data System (ADS)

Tsai, Bi-Huei; Chang, Chih-Huei

2009-08-01

Previous studies used constant cut-off indicator to distinguish distressed firms from non-distressed ones in the one-stage prediction models. However, distressed cut-off indicator must shift according to economic prosperity, rather than remains fixed all the time. This study focuses on Taiwanese listed firms and develops financial distress prediction models based upon the two-stage method. First, this study employs the firm-specific financial ratio and market factors to measure the probability of financial distress based on the discrete-time hazard models. Second, this paper further focuses on macroeconomic factors and applies rating transition matrix approach to determine the distressed cut-off indicator. The prediction models are developed by using the training sample from 1987 to 2004, and their levels of accuracy are compared with the test sample from 2005 to 2007. As for the one-stage prediction model, the model in incorporation with macroeconomic factors does not perform better than that without macroeconomic factors. This suggests that the accuracy is not improved for one-stage models which pool the firm-specific and macroeconomic factors together. In regards to the two stage models, the negative credit cycle index implies the worse economic status during the test period, so the distressed cut-off point is adjusted to increase based on such negative credit cycle index. After the two-stage models employ such adjusted cut-off point to discriminate the distressed firms from non-distressed ones, their error of misclassification becomes lower than that of one-stage ones. The two-stage models presented in this paper have incremental usefulness in predicting financial distress.

Application of historical mobility testing to sensor-based robotic performance

NASA Astrophysics Data System (ADS)

Willoughby, William E.; Jones, Randolph A.; Mason, George L.; Shoop, Sally A.; Lever, James H.

2006-05-01

The USA Engineer Research and Development Center (ERDC) has conducted on-/off-road experimental field testing with full-sized and scale-model military vehicles for more than fifty years. Some 4000 acres of local terrain are available for tailored field evaluations or verification/validation of future robotic designs in a variety of climatic regimes. Field testing and data collection procedures, as well as techniques for quantifying terrain in engineering terms, have been developed and refined into algorithms and models for predicting vehicle-terrain interactions and resulting forces or speeds of military-sized vehicles. Based on recent experiments with Matilda, Talon, and Pacbot, these predictive capabilities appear to be relevant to most robotic systems currently in development. Utilization of current testing capabilities with sensor-based vehicle drivers, or use of the procedures for terrain quantification from sensor data, would immediately apply some fifty years of historical knowledge to the development, refinement, and implementation of future robotic systems. Additionally, translation of sensor-collected terrain data into engineering terms would allow assessment of robotic performance a priori deployment of the actual system and ensure maximum system performance in the theater of operation.

Investigation of the part-load performance of two 1.12 MW regenerative marine gas turbines

NASA Astrophysics Data System (ADS)

Korakianitis, T.; Beier, K. J.

1994-04-01

Regenerative and intercooled-regenerative gas turbine engines with low pressure ratio have significant efficiency advantages over traditional aero-derivative engines of higher pressure ratios, and can compete with modern diesel engines for marine propulsion. Their performance is extremely sensitive to thermodynamic-cycle parameter choices and the type of components. The performances of two 1.12 MW (1500 hp) regenerative gas turbines are predicted with computer simulations. One engine has a single-shaft configuration, and the other has a gas-generator/power-turbine combination. The latter arrangement is essential for wide off-design operating regime. The performance of each engine driving fixed-pitch and controllable-pitch propellers, or an AC electric bus (for electric-motor-driven propellers) is investigated. For commercial applications the controllable-pitch propeller may have efficiency advantages (depending on engine type and shaft arrangements). For military applications the electric drive provides better operational flexibility.

On the performance of a high head Francis turbine at design and off-design conditions

NASA Astrophysics Data System (ADS)

Aakti, B.; Amstutz, O.; Casartelli, E.; Romanelli, G.; Mangani, L.

2015-01-01

In the present paper, fully 360 degrees transient and steady-state simulations of a Francis turbine were performed at three operating conditions, namely at part load (PL), best efficiency point (BEP), and high load (HL), using different numerical approaches for the pressure-velocity coupling. The simulation domain includes the spiral casing with stay and guide vanes, the runner and the draft tube. The main target of the investigations is the numerical prediction of the overall performance of the high head Francis turbine model as well as local and integral quantities of the complete machine in different operating conditions. All results were compared with experimental data published by the workshop organization. All CFD simulations were performed at model scale with a new in-house, 3D, unstructured, object-oriented finite volume code within the framework of the open source OpenFOAM library. The novel fully coupled pressure-based solver is designed to solve the incompressible RANS- Equations and is capable of handling multiple references of frame (MRF). The obtained results show that the overall performance is well captured by the simulations. Regarding the local flow distributions within the inlet section of the draft-tube, the axial velocity is better estimated than the circumferential component.

An ensemble model of QSAR tools for regulatory risk assessment.

PubMed

Pradeep, Prachi; Povinelli, Richard J; White, Shannon; Merrill, Stephen J

2016-01-01

Quantitative structure activity relationships (QSARs) are theoretical models that relate a quantitative measure of chemical structure to a physical property or a biological effect. QSAR predictions can be used for chemical risk assessment for protection of human and environmental health, which makes them interesting to regulators, especially in the absence of experimental data. For compatibility with regulatory use, QSAR models should be transparent, reproducible and optimized to minimize the number of false negatives. In silico QSAR tools are gaining wide acceptance as a faster alternative to otherwise time-consuming clinical and animal testing methods. However, different QSAR tools often make conflicting predictions for a given chemical and may also vary in their predictive performance across different chemical datasets. In a regulatory context, conflicting predictions raise interpretation, validation and adequacy concerns. To address these concerns, ensemble learning techniques in the machine learning paradigm can be used to integrate predictions from multiple tools. By leveraging various underlying QSAR algorithms and training datasets, the resulting consensus prediction should yield better overall predictive ability. We present a novel ensemble QSAR model using Bayesian classification. The model allows for varying a cut-off parameter that allows for a selection in the desirable trade-off between model sensitivity and specificity. The predictive performance of the ensemble model is compared with four in silico tools (Toxtree, Lazar, OECD Toolbox, and Danish QSAR) to predict carcinogenicity for a dataset of air toxins (332 chemicals) and a subset of the gold carcinogenic potency database (480 chemicals). Leave-one-out cross validation results show that the ensemble model achieves the best trade-off between sensitivity and specificity (accuracy: 83.8 % and 80.4 %, and balanced accuracy: 80.6 % and 80.8 %) and highest inter-rater agreement [kappa ( κ ): 0.63 and 0.62] for both the datasets. The ROC curves demonstrate the utility of the cut-off feature in the predictive ability of the ensemble model. This feature provides an additional control to the regulators in grading a chemical based on the severity of the toxic endpoint under study.

An ensemble model of QSAR tools for regulatory risk assessment

DOE PAGES

Pradeep, Prachi; Povinelli, Richard J.; White, Shannon; ...

2016-09-22

Quantitative structure activity relationships (QSARs) are theoretical models that relate a quantitative measure of chemical structure to a physical property or a biological effect. QSAR predictions can be used for chemical risk assessment for protection of human and environmental health, which makes them interesting to regulators, especially in the absence of experimental data. For compatibility with regulatory use, QSAR models should be transparent, reproducible and optimized to minimize the number of false negatives. In silico QSAR tools are gaining wide acceptance as a faster alternative to otherwise time-consuming clinical and animal testing methods. However, different QSAR tools often make conflictingmore » predictions for a given chemical and may also vary in their predictive performance across different chemical datasets. In a regulatory context, conflicting predictions raise interpretation, validation and adequacy concerns. To address these concerns, ensemble learning techniques in the machine learning paradigm can be used to integrate predictions from multiple tools. By leveraging various underlying QSAR algorithms and training datasets, the resulting consensus prediction should yield better overall predictive ability. We present a novel ensemble QSAR model using Bayesian classification. The model allows for varying a cut-off parameter that allows for a selection in the desirable trade-off between model sensitivity and specificity. The predictive performance of the ensemble model is compared with four in silico tools (Toxtree, Lazar, OECD Toolbox, and Danish QSAR) to predict carcinogenicity for a dataset of air toxins (332 chemicals) and a subset of the gold carcinogenic potency database (480 chemicals). Leave-one-out cross validation results show that the ensemble model achieves the best trade-off between sensitivity and specificity (accuracy: 83.8 % and 80.4 %, and balanced accuracy: 80.6 % and 80.8 %) and highest inter-rater agreement [kappa (κ): 0.63 and 0.62] for both the datasets. The ROC curves demonstrate the utility of the cut-off feature in the predictive ability of the ensemble model. In conclusion, this feature provides an additional control to the regulators in grading a chemical based on the severity of the toxic endpoint under study.« less

Optimal platform design using non-dominated sorting genetic algorithm II and technique for order of preference by similarity to ideal solution; application to automotive suspension system

NASA Astrophysics Data System (ADS)

Shojaeefard, Mohammad Hassan; Khalkhali, Abolfazl; Faghihian, Hamed; Dahmardeh, Masoud

2018-03-01

Unlike conventional approaches where optimization is performed on a unique component of a specific product, optimum design of a set of components for employing in a product family can cause significant reduction in costs. Increasing commonality and performance of the product platform simultaneously is a multi-objective optimization problem (MOP). Several optimization methods are reported to solve these MOPs. However, what is less discussed is how to find the trade-off points among the obtained non-dominated optimum points. This article investigates the optimal design of a product family using non-dominated sorting genetic algorithm II (NSGA-II) and proposes the employment of technique for order of preference by similarity to ideal solution (TOPSIS) method to find the trade-off points among the obtained non-dominated results while compromising all objective functions together. A case study for a family of suspension systems is presented, considering performance and commonality. The results indicate the effectiveness of the proposed method to obtain the trade-off points with the best possible performance while maximizing the common parts.

Is waist circumference a better predictor of diabetes than body mass index or waist-to-height ratio in Iranian adults?

PubMed

Hajian-Tilaki, Karimollah; Heidari, Bezad

2015-01-01

Several measures of adiposity have been used for predicting diabetes. The results of studies regarding superiority of waist circumference (WC) to body mass index (BMI) are inconsistent. This study designed to compare the ability of different anthropometric measures in predicting diabetes and to determine their optimal cut-off values. A population-based cross-sectional study was conducted with 1,000 representative sample among adults aged 20-80 years in Babol, the Northern Iran. The demographic data were collected in a household survey, and the anthropometric measures of weight, height, waist, and hip circumference were measured with a standard method. Fasting blood sugar (FBS) ≥126 mg/dl was considered as diabetes. receiver operating characteristic analysis was used to estimate the predictive ability of different anthropometric indexes and their optimal cut-off values for high FBS. The overall prevalence rate of diabetes was 14.0% (14.4% in men vs. 13.5% in women, P = 0.65). The prevalence rate was significantly higher in older age (>60 years), low educated and obese (P = 0.001). The mean of BMI, WC, waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) were significantly higher among diabetic in both sexes (P = 0.001). Among men, WC (area under the ROC curve [AUC] =0.64) and WHtR (AUC = 0.63) have slightly higher accuracy index compared with BMI (AUC = 0.62) or WHR (AUC = 0.60). In contrast, among women, WHtR (AUC = 0.69) and WC (AUC = 0.68) yielded slightly better predictive than BMI (AUC = 0.67). The optimal cut-off values obtained for BMI and WHtR were similar between two sexes (BMI = 24.95 kg/m(2) for men and BMI = 25.2 kg/m(2) for women, WHtR = 0.51 for both sexes) whereas the optimal cut-off value for WC was higher in men than women (98.5 cm men vs. 89.5 cm women). Overall WC and WHtR exhibited a slightly better discriminate performance than BMI for diabetes in both sexes, particularly in women.

ACSYNT inner loop flight control design study

NASA Technical Reports Server (NTRS)

Bortins, Richard; Sorensen, John A.

1993-01-01

The NASA Ames Research Center developed the Aircraft Synthesis (ACSYNT) computer program to synthesize conceptual future aircraft designs and to evaluate critical performance metrics early in the design process before significant resources are committed and cost decisions made. ACSYNT uses steady-state performance metrics, such as aircraft range, payload, and fuel consumption, and static performance metrics, such as the control authority required for the takeoff rotation and for landing with an engine out, to evaluate conceptual aircraft designs. It can also optimize designs with respect to selected criteria and constraints. Many modern aircraft have stability provided by the flight control system rather than by the airframe. This may allow the aircraft designer to increase combat agility, or decrease trim drag, for increased range and payload. This strategy requires concurrent design of the airframe and the flight control system, making trade-offs of performance and dynamics during the earliest stages of design. ACSYNT presently lacks means to implement flight control system designs but research is being done to add methods for predicting rotational degrees of freedom and control effector performance. A software module to compute and analyze the dynamics of the aircraft and to compute feedback gains and analyze closed loop dynamics is required. The data gained from these analyses can then be fed back to the aircraft design process so that the effects of the flight control system and the airframe on aircraft performance can be included as design metrics. This report presents results of a feasibility study and the initial design work to add an inner loop flight control system (ILFCS) design capability to the stability and control module in ACSYNT. The overall objective is to provide a capability for concurrent design of the aircraft and its flight control system, and enable concept designers to improve performance by exploiting the interrelationships between aircraft and flight control system design parameters.

Performance Benefits for Wave Rotor-Topped Gas Turbine Engines

NASA Technical Reports Server (NTRS)

Jones, Scott M.; Welch, Gerard E.

1996-01-01

The benefits of wave rotor-topping in turboshaft engines, subsonic high-bypass turbofan engines, auxiliary power units, and ground power units are evaluated. The thermodynamic cycle performance is modeled using a one-dimensional steady-state code; wave rotor performance is modeled using one-dimensional design/analysis codes. Design and off-design engine performance is calculated for baseline engines and wave rotor-topped engines, where the wave rotor acts as a high pressure spool. The wave rotor-enhanced engines are shown to have benefits in specific power and specific fuel flow over the baseline engines without increasing turbine inlet temperature. The off-design steady-state behavior of a wave rotor-topped engine is shown to be similar to a conventional engine. Mission studies are performed to quantify aircraft performance benefits for various wave rotor cycle and weight parameters. Gas turbine engine cycles most likely to benefit from wave rotor-topping are identified. Issues of practical integration and the corresponding technical challenges with various engine types are discussed.

More complete gene silencing by fewer siRNAs: transparent optimized design and biophysical signature

PubMed Central

Ladunga, Istvan

2007-01-01

Highly accurate knockdown functional analyses based on RNA interference (RNAi) require the possible most complete hydrolysis of the targeted mRNA while avoiding the degradation of untargeted genes (off-target effects). This in turn requires significant improvements to target selection for two reasons. First, the average silencing activity of randomly selected siRNAs is as low as 62%. Second, applying more than five different siRNAs may lead to saturation of the RNA-induced silencing complex (RISC) and to the degradation of untargeted genes. Therefore, selecting a small number of highly active siRNAs is critical for maximizing knockdown and minimizing off-target effects. To satisfy these needs, a publicly available and transparent machine learning tool is presented that ranks all possible siRNAs for each targeted gene. Support vector machines (SVMs) with polynomial kernels and constrained optimization models select and utilize the most predictive effective combinations from 572 sequence, thermodynamic, accessibility and self-hairpin features over 2200 published siRNAs. This tool reaches an accuracy of 92.3% in cross-validation experiments. We fully present the underlying biophysical signature that involves free energy, accessibility and dinucleotide characteristics. We show that while complete silencing is possible at certain structured target sites, accessibility information improves the prediction of the 90% active siRNA target sites. Fast siRNA activity predictions can be performed on our web server at . PMID:17169992

Distortion definition and correction in off-axis systems

NASA Astrophysics Data System (ADS)

Da Deppo, Vania; Simioni, Emanuele; Naletto, Giampiero; Cremonese, Gabriele

2015-09-01

Off-axis optical configurations are becoming more and more used in a variety of applications, in particular they are the most preferred solution for cameras devoted to Solar System planets and small bodies (i.e. asteroids and comets) study. Off-axis designs, being devoid of central obstruction, are able to guarantee better PSF and MTF performance, and thus higher contrast imaging capabilities with respect to classical on-axis designs. In particular they are suitable for observing extended targets with intrinsic low contrast features, or scenes where a high dynamical signal range is present. Classical distortion theory is able to well describe the performance of the on-axis systems, but it has to be adapted for the off-axis case. A proper way to deal with off-axis distortion definition is thus needed together with dedicated techniques to accurately measure and hence remove the distortion effects present in the acquired images. In this paper, a review of the distortion definition for off-axis systems will be given. In particular the method adopted by the authors to deal with the distortion related issues (definition, measure, removal) in some off-axis instruments will be described in detail.

Automatic control design procedures for restructurable aircraft control

NASA Technical Reports Server (NTRS)

Looze, D. P.; Krolewski, S.; Weiss, J.; Barrett, N.; Eterno, J.

1985-01-01

A simple, reliable automatic redesign procedure for restructurable control is discussed. This procedure is based on Linear Quadratic (LQ) design methodologies. It employs a robust control system design for the unfailed aircraft to minimize the effects of failed surfaces and to extend the time available for restructuring the Flight Control System. The procedure uses the LQ design parameters for the unfailed system as a basis for choosing the design parameters of the failed system. This philosophy alloys the engineering trade-offs that were present in the nominal design to the inherited by the restructurable design. In particular, it alloys bandwidth limitations and performance trade-offs to be incorporated in the redesigned system. The procedure also has several other desirable features. It effectively redistributes authority among the available control effectors to maximize the system performance subject to actuator limitations and constraints. It provides a graceful performance degradation as the amount of control authority lessens. When given the parameters of the unfailed aircraft, the automatic redesign procedure reproduces the nominal control system design.

Mechanics of damping for fiber composite laminates including hygro-thermal effects

NASA Technical Reports Server (NTRS)

Saravanos, D. A.; Chamis, C. C.

1989-01-01

An integrated mechanics theory has been developed for the modeling of composite damping from the micromechanics to the laminate level. Simplified, design oriented equations based on hysteretic damping are presented for on-axis plies, off-axis plies, and laminates including the effect of temperature, moisture, and interply hysteretic damping. The temperature rise within vibrating composite laminates resulting from strain energy dissipation is also modeled, and their coupled hygro-thermo-mechanical response is predicted. The method correlates well with reported damping measurements. Application examples illustrate the effect of various ply, laminate, and hygro-thermal parameters on the overall damping performance of composite laminates.

Mechanics of damping for fiber composite laminates including hygro-thermal effects

NASA Technical Reports Server (NTRS)

Saravanos, D. A.; Chamis, Christos C.

1989-01-01

An integrated mechanics theory was developed for the modeling of composite damping from the micromechanics to the laminate level. Simplified, design oriented equations based on hysteretic damping are presented for on-axis plies, off-axis plies, and laminates including the effect of temperature, moisture, and interply hysteretic damping. The temperature rise within vibrating composite laminates resulting from strain energy dissipation is also modeled, and their coupled hygro-thermo-mechanical response is predicted. The method correlates well with reported damping measurements. Application examples illustrate the effect of various ply, laminate, and hygro-thermal parameters on the overall damping performance of composite laminates.

The cut-off values of anthropometric variables for predicting mild cognitive impairment in Malaysian older adults: a large population based cross-sectional study.

PubMed

Won, Huiloo; Abdul, Manaf Zahara; Mat Ludin, Arimi Fitri; Omar, Mohd Azahadi; Razali, Rosdinom; Shahar, Suzana

2017-01-01

Older adults are at risk of mild cognitive impairment (MCI), and simple anthropometric measurements can be used to screen for this condition. Thus, the aim of this study was to explore the cut-off values of body mass index (BMI) and waist circumference (WC) for predicting the risk of MCI in older Malaysian adults. A total of 2,240 Malaysian older adults aged ≥60 years were recruited using multistage random sampling in a population based cross-sectional study. Receiver operating characteristic (ROC) curve was used to determine the cut-off values of BMI and WC with optimum sensitivity and specificity for the detection of MCI. Age, gender, years of education, smoking habit, alcohol consumption, depression, and medical conditions were used as confounding factors in this analysis. A BMI cut-off value of 26 kg/m 2 (area under the receiver operating characteristic curve [AUC] 0.725; sensitivity 90.5%; specificity 38.8%) was appropriate in identifying the risk of getting MCI in both men and women. The optimum WC cut-offs for likelihood of MCI were 90 cm (AUC 0.745; sensitivity 78.0%; specificity 59.8%) for men and 82 cm (AUC 0.714; sensitivity 84.3%; specificity 49.7%) for women. The optimum calf circumference (CC) cut-off values for identifying MCI were 29 cm (AUC 0.731; sensitivity 72.6%; specificity 61.1%) for men and 26 cm (AUC 0.598; sensitivity 79.1%; specificity 45.3%) for women. The cut-off values could be advocated and used as part of the screening of MCI among older Malaysian adults. There is a need to further determine the predictive values of these cut-off points on outcomes through longitudinal study design.

Rear wheel torque vectoring model predictive control with velocity regulation for electric vehicles

NASA Astrophysics Data System (ADS)

Siampis, Efstathios; Velenis, Efstathios; Longo, Stefano

2015-11-01

In this paper we propose a constrained optimal control architecture for combined velocity, yaw and sideslip regulation for stabilisation of the vehicle near the limit of lateral acceleration using the rear axle electric torque vectoring configuration of an electric vehicle. A nonlinear vehicle and tyre model are used to find reference steady-state cornering conditions and design two model predictive control (MPC) strategies of different levels of fidelity: one that uses a linearised version of the full vehicle model with the rear wheels' torques as the input, and another one that neglects the wheel dynamics and uses the rear wheels' slips as the input instead. After analysing the relative trade-offs between performance and computational effort, we compare the two MPC strategies against each other and against an unconstrained optimal control strategy in Simulink and Carsim environment.

Streamflow simulation for continental-scale river basins

NASA Astrophysics Data System (ADS)

Nijssen, Bart; Lettenmaier, Dennis P.; Liang, Xu; Wetzel, Suzanne W.; Wood, Eric F.

1997-04-01

A grid network version of the two-layer variable infiltration capacity (VIC-2L) macroscale hydrologic model is described. VIC-2L is a hydrologically based soil- vegetation-atmosphere transfer scheme designed to represent the land surface in numerical weather prediction and climate models. The grid network scheme allows streamflow to be predicted for large continental rivers. Off-line (observed and estimated surface meteorological and radiative forcings) applications of the model to the Columbia River (1° latitude-longitude spatial resolution) and Delaware River (0.5° resolution) are described. The model performed quite well in both applications, reproducing the seasonal hydrograph and annual flow volumes to within a few percent. Difficulties in reproducing observed streamflow in the arid portion of the Snake River basin are attributed to groundwater-surface water interactions, which are not modeled by VIC-2L.

Development of a Simulation Capability for the Space Station Active Rack Isolation System

NASA Technical Reports Server (NTRS)

Johnson, Terry L.; Tolson, Robert H.

1998-01-01

To realize quality microgravity science on the International Space Station, many microgravity facilities will utilize the Active Rack Isolation System (ARIS). Simulation capabilities for ARIS will be needed to predict the microgravity environment. This paper discusses the development of a simulation model for use in predicting the performance of the ARIS in attenuating disturbances with frequency content between 0.01 Hz and 10 Hz. The derivation of the model utilizes an energy-based approach. The complete simulation includes the dynamic model of the ISPR integrated with the model for the ARIS controller so that the entire closed-loop system is simulated. Preliminary performance predictions are made for the ARIS in attenuating both off-board disturbances as well as disturbances from hardware mounted onboard the microgravity facility. These predictions suggest that the ARIS does eliminate resonant behavior detrimental to microgravity experimentation. A limited comparison is made between the simulation predictions of ARIS attenuation of off-board disturbances and results from the ARIS flight test. These comparisons show promise, but further tuning of the simulation is needed.

Optomechanical stability design of space optical mapping camera

NASA Astrophysics Data System (ADS)

Li, Fuqiang; Cai, Weijun; Zhang, Fengqin; Li, Na; Fan, Junjie

2018-01-01

According to the interior orientation elements and imaging quality requirements of mapping application to mapping camera and combined with off-axis three-mirror anastigmat(TMA) system, high optomechanical stability design of a space optical mapping camera is introduced in this paper. The configuration is a coaxial TMA system used in off-axis situation. Firstly, the overall optical arrangement is described., and an overview of the optomechanical packaging is provided. Zerodurglass, carbon fiber composite and carbon-fiber reinforced silicon carbon (C/SiC) are widely used in the optomechanical structure, because their low coefficient of thermal expansion (CTE) can reduce the thermal sensitivity of the mirrors and focal plane. Flexible and unloading support are used in reflector and camera supporting structure. Epoxy structural adhesives is used for bonding optics to metal structure is also introduced in this paper. The primary mirror is mounted by means of three-point ball joint flexures system, which is attach to the back of the mirror. Then, In order to predict flexural displacements due to gravity, static finite element analysis (FEA) is performed on the primary mirror. The optical performance peak-to-valley (PV) and root-mean-square (RMS) wavefront errors are detected before and after assemble. Also, the dynamic finite element analysis(FEA) of the whole optical arrangement is carried out as to investigate the performance of optomechanical. Finally, in order to evaluate the stability of the design, the thermal vacuum test and vibration test are carried out and the Modulation Transfer Function (MTF) and elements of interior orientation are presented as the evaluation index. Before and after the thermal vacuum test and vibration test, the MTF, focal distance and position of the principal point of optical system are measured and the result is as expected.

Drop-off Detection with the Long Cane: Effects of Different Cane Techniques on Performance

PubMed Central

Kim, Dae Shik; Emerson, Robert Wall; Curtis, Amy

2010-01-01

This study compared the drop-off detection performance with the two-point touch and constant contact cane techniques using a repeated-measures design with a convenience sample of 15 cane users with visual impairments. The constant contact technique was superior to the two-point touch technique in the drop-off detection rate and the 50% detection threshold. The findings may help an orientation and mobility instructor select an appropriate technique for a particular client or training situation. PMID:21209791

Structural analysis of an off-grid tiny house

NASA Astrophysics Data System (ADS)

Calluari, Karina Arias; Alonso-Marroquín, Fernando

2017-06-01

The off-grid technologies and tiny house movement have experimented an unprecedented growth in recent years. Putting both sides together, we are trying to achieve an economic and environmental friendly solution to the higher cost of residential properties. This solution is the construction of off-grid tiny houses. This article presents a design for a small modular off-grid house made by pine timber. A numerical analysis of the proposed tiny house was performed to ensure its structural stability. The results were compared with the suggested serviceability limit state criteria, which are contended in the Australia Guidelines Standards making this design reliable for construction.

Vehicle integration effects on hypersonic waveriders. M.S. Thesis - George Washington Univ.

NASA Technical Reports Server (NTRS)

Cockrell, Charles Edward, Jr.

1994-01-01

The integration of a class of hypersonic high-lift configurations known as waveriders into hypersonic cruise vehicles was evaluated. Waveriders offer advantages in aerodynamic performance and propulsion/airframe integration (PAI) characteristics over conventional hypersonic shapes. A wind-tunnel model was developed which integrates realistic vehicle components with two waverider shapes, referred to as the 'straight-wing' and 'cranked-wing' shapes. Both shapes were conical-flow-derived waveriders at a design Mach number of 4.0. The cranked-wing shape was designed to provide advantages in subsonic performance and directional stability over conventional waveriders. Experimental data and limited computational fluid dynamics (CFD) predictions were obtained over a Mach number range of 2.3 to 4.63 at a Reynolds number of 2.0x10(exp 6) per foot. The CFD predictions and flow visualization data confirmed the shock attachment characteristics of the baseline waverider shapes and illustrated the waverider flow-field properties. Both CFD predictions and experimental data showed that no significant performance degradations occur at off-design Mach numbers for the waverider shapes and the integrated configurations. The experimental data showed that the effects of adding a realistic canopy were minimal. The effects of adding engine components were to increase the drag and thus degrade the aerodynamic performance of the configuration. A significant degradation in aerodynamic performance was observed when 0 degree control surfaces were added to close the blunt base of the waverider to a sharp trailing edge. A comparison of the fully-integrated waverider models to the baseline shapes showed that the performance was significantly degraded when all of the components were added to the waveriders. The fully-integrated configurations studied here do not offer significant performance advantages over conventional hypersonic vehicles, but still offer advantages in air-breathing propulsion integration. Additionally, areas are identified in this study where improvements could be made to enhance the performance. Both fully-integrated configurations are longitudinally unstable over the Mach number range studied for unpowered conditions. The cranked-wing fully-integrated configuration provided significantly better lateral-directional stability characteristics than the straight-wing configuration.

Integration of Off-Track Sonic Boom Analysis in Conceptual Design of Supersonic Aircraft

NASA Technical Reports Server (NTRS)

Ordaz, Irian; Li, Wu

2011-01-01

A highly desired capability for the conceptual design of aircraft is the ability to rapidly and accurately evaluate new concepts to avoid adverse trade decisions that may hinder the development process in the later stages of design. Evaluating the robustness of new low-boom concepts is important for the conceptual design of supersonic aircraft. Here, robustness means that the aircraft configuration has a low-boom ground signature at both under- and off-track locations. An integrated process for off-track boom analysis is developed to facilitate the design of robust low-boom supersonic aircraft. The integrated off-track analysis can also be used to study the sonic boom impact and to plan future flight trajectories where flight conditions and ground elevation might have a significant effect on ground signatures. The key enabler for off-track sonic boom analysis is accurate computational fluid dynamics (CFD) solutions for off-body pressure distributions. To ensure the numerical accuracy of the off-body pressure distributions, a mesh study is performed with Cart3D to determine the mesh requirements for off- body CFD analysis and comparisons are made between the Cart3D and USM3D results. The variations in ground signatures that result from changes in the initial location of the near-field waveform are also examined. Finally, a complete under- and off-track sonic boom analysis is presented for two distinct supersonic concepts to demonstrate the capability of the integrated analysis process.

Water Flow Performance of a Superscale Model of the Fastrac Liquid Oxygen Pump

NASA Technical Reports Server (NTRS)

Skelley, Stephen; Zoladz, Thomas

2001-01-01

As part of the National Aeronautics and Space Administration's ongoing effort to lower the cost of access to space, the Marshall Space Flight Center has developed a rocket engine with 60,000 pounds of thrust for use on the Reusable Launch Vehicle technology demonstrator slated for launch in 2000. This gas generator cycle engine, known as the Fastrac engine, uses liquid oxygen and RP-1 for propellants and includes single stage liquid oxygen and RP-1 pumps and a single stage supersonic turbine on a common shaft. The turbopump design effort included the first use and application of new suction capability prediction codes and three-dimensional blade generation codes in an attempt to reduce the turbomachinery design and certification costs typically associated with rocket engine development. To verify the pump's predicted cavitation performance, a water flow test of a superscale model of the Fastrac liquid oxygen pump was conducted to experimentally evaluate the liquid oxygen pump's performance at and around the design point. The water flow test article replicated the flow path of the Fastrac liquid oxygen pump in a 1.582x scale model, including scaled seal clearances for correct leakage flow at a model operating speed of 5000 revolutions per minute. Flow entered the 3-blade axial-flow inducer, transitioned to a shrouded, 6- blade radial impeller, and discharged into a vaneless radial diffuser and collection volute. The test article included approximately 50 total and static pressure measurement locations as well as flush-mounted, high frequency pressure transducers for complete mapping of the pressure environment. The primary objectives of the water flow test were to measure the steady-state and dynamic pressure environment of the liquid oxygen pump versus flow coefficient, suction specific speed, and back face leakage flow rate. Initial results showed acceptable correlation between the predicted and experimentally measured pump head rise at low suction specific speeds. Likewise, only small circumferential variations in steady-state were observed from 80% to 120% of the design flow coefficient, matching the computational predictions and confirming that the integrated design approach has minimized any exit volute-induced distortions. The test article exhibited suction performance trends typically observed in inducer designs with virtually constant head rise with decreasing inlet pressure until complete pump head breakdown. Unfortunately, the net positive suction head at 3% head fall-off occurred far below that predicted at all tested flow coefficients, resulting in a negative net positive suction head margin at the design point in water. Additional testing to map the unsteady pressure environment was conducted and cavitation-induced flow disturbances at the inducer inlet were observed. Two distinct disturbances were identified, one rotating and one stationary relative to the fixed frame of reference, while the transition from one regime to the next produced significant effects on the steady state pump performance. The impact of the unsteady phenomena and the corresponding energy losses on the unexpectedly poor pump performance is also discussed.

Series-parallel solar-augmented rock-bed heat pump. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sowell, E.F.; Othmer, P.W.

1979-12-31

This report deals with a system representing an alternate arrangement of the components in an air-type, heat pump augmented solar heating system. In this system, referred to as Series-Parallel, the heat pump coils are at opposite ends of the rock bed, allowing heating and cooling of the air entering and leaving the bed. This allows a number of unique modes of operation, some of which allow off-peak use of the necessary utility power. Cooling modes are also available, including off-peak cooling-effect storage, night cooling, and free cooling (economizing). The system finds applications principally in single-family residences. The study examined themore » performance of this system at three locations (Sacramento, Albuquerque, and New York) by means of a simulation model. Seasonal heating and cooling performance factors of about 3 were obtained for Albuquerque for the system integrated into a 200 m/sup 2/ residence. Design integration studies suggest an installed cost of approximately $28,000 above a conventional heat pump system using commercially available components. This high cost is largely due to solar hardware, although system complexity also adds. Availability of low-cost air type collectors may make the system attractive. The study also addresses the general problem of predictive control necessary whenever off-peak storage is employed. An algorithm is presented, along with results.« less

2013 CEF RUN - PHASE 1 DATA ANALYSIS AND MODEL VALIDATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Choi, A.

2014-05-08

Phase 1 of the 2013 Cold cap Evaluation Furnace (CEF) test was completed on June 3, 2013 after a 5-day round-the-clock feeding and pouring operation. The main goal of the test was to characterize the CEF off-gas produced from a nitric-formic acid flowsheet feed and confirm whether the CEF platform is capable of producing scalable off-gas data necessary for the revision of the DWPF melter off-gas flammability model; the revised model will be used to define new safety controls on the key operating parameters for the nitric-glycolic acid flowsheet feeds including total organic carbon (TOC). Whether the CEF off-gas datamore » were scalable for the purpose of predicting the potential flammability of the DWPF melter exhaust was determined by comparing the predicted H{sub 2} and CO concentrations using the current DWPF melter off-gas flammability model to those measured during Phase 1; data were deemed scalable if the calculated fractional conversions of TOC-to-H{sub 2} and TOC-to-CO at varying melter vapor space temperatures were found to trend and further bound the respective measured data with some margin of safety. Being scalable thus means that for a given feed chemistry the instantaneous flow rates of H{sub 2} and CO in the DWPF melter exhaust can be estimated with some degree of conservatism by multiplying those of the respective gases from a pilot-scale melter by the feed rate ratio. This report documents the results of the Phase 1 data analysis and the necessary calculations performed to determine the scalability of the CEF off-gas data. A total of six steady state runs were made during Phase 1 under non-bubbled conditions by varying the CEF vapor space temperature from near 700 to below 300°C, as measured in a thermowell (T{sub tw}). At each steady state temperature, the off-gas composition was monitored continuously for two hours using MS, GC, and FTIR in order to track mainly H{sub 2}, CO, CO{sub 2}, NO{sub x}, and organic gases such as CH{sub 4}. The standard deviation of the average vapor space temperature during each steady state ranged from 2 to 6°C; however, those of the measured off-gas data were much larger due to the inherent cold cap instabilities in the slurry-fed melters. In order to predict the off-gas composition at the sampling location downstream of the film cooler, the measured feed composition was charge-reconciled and input into the DWPF melter off-gas flammability model, which was then run under the conditions for each of the six Phase 1 steady states. In doing so, it was necessary to perform an overall heat/mass balance calculation from the melter to the Off-Gas Condensate Tank (OGCT) in order to estimate the rate of air inleakage as well as the true gas temperature in the CEF vapor space (T{sub gas}) during each steady state by taking into account the effects of thermal radiation on the measured temperature (T{sub tw}). The results of Phase 1 data analysis and subsequent model runs showed that the predicted concentrations of H{sub 2} and CO by the DWPF model correctly trended and further bounded the respective measured data in the CEF off-gas by over predicting the TOC-to-H{sub 2} and TOC-to-CO conversion ratios by a factor of 2 to 5; an exception was the 7X over prediction of the latter at T{sub gas} = 371°C but the impact of CO on the off-gas flammability potential is only minor compared to that of H{sub 2}. More importantly, the seemingly-excessive over prediction of the TOC-to-H{sub 2} conversion by a factor of 4 or higher at T{sub gas} < ~350°C was attributed to the conservative antifoam decomposition scheme added recently to the model and therefore is considered a modeling issue and not a design issue. At T{sub gas} > ~350°C, the predicted TOC-to-H{sub 2} conversions were closer to but still higher than the measured data by a factor of 2, which may be regarded as adequate from the safety margin standpoint. The heat/mass balance calculations also showed that the correlation between T{sub tw} and T{sub gas} in the CEF vapor space was close to that of the ½ scale SGM, whose data were taken as directly applicable to the DWPF melter and thus used to set all the parameters of the original model. Based on these results of the CEF Phase 1 off-gas and thermal data analyses, it is concluded that: (1) The thermal characteristics of the CEF vapor space are prototypic thanks to its prototypic design; and (2) The CEF off-gas data are scalable in terms of predicting the flammability potential of the DWPF melter off-gas. These results also show that the existing DWPF safety controls on the TOC and antifoam as a function of nitrate are conservative by the same order of magnitude shown by the Phase 1 data at T{sub gas} < ~350°C, since they were set at T{sub gas} = 294°C, which falls into the region of excessive conservatism for the current DWPF model in terms of predicting the TOC-to-H{sub 2} conversion. In order to remedy the overly-conservative antifoam decomposition scheme used in the current DWPF model, the data from two recent tests will be analyzed in detail in order to gain additional insights into the antifoam decomposition chemistry in the cold cap. The first test was run in a temperature-programmed furnace using both normal and spiked feeds with fresh antifoam under inert and slightly oxidizing vapor space conditions. Phase 2 of the CEF test was run with the baseline nitric-glycolic acid flowsheet feeds that contained the “processed antifoam” and those spiked with fresh antifoam in order to study the effects of antifoam concentration as well as processing history on its decomposition chemistry under actual melter conditions. The goal is to develop an improved antifoam decomposition model from the analysis of these test data and incorporate it into a new multistage cold cap model to be developed concurrently for the nitric-glycolic acid flowsheet feeds. These activities will be documented in the Phase 2 report. Finally, it is recommended that some of the conservatism in the existing DWPF safety controls be removed by improving the existing measured-vs.-true gas temperature correlation used in the melter vapor space combustion calculations. The basis for this recommendation comes from the fact that the existing correlation was developed by linearly extrapolating the SGM data taken over a relatively narrow temperature range down to the safety basis minimum of 460°C, thereby under predicting the true gas temperature considerably, as documented in this report. Specifically, the task of improving the current temperature correlation will involve; (1) performing a similar heat/mass balance analysis used in this study on actual DWPF data, (2) validating the measured-vs.-true gas temperature correlation for the CEF developed in this study against the DWPF melter heat/mass balance results, and (3) making adjustments to the CEF correlation, if necessary, before incorporating it into the DWPF safety basis calculations. The steps described here can be completed with relatively minimum efforts.« less

Multiport optical circulator by using polarizing beam splitter cubes as spatial walk-off polarizers.

PubMed

Chen, Jing-Heng; Chen, Kun-Huang; Lin, Jiun-You; Hsieh, Hsiang-Yung

2010-03-10

Optical circulators are necessary passive devices applied in optical communication systems. In the design of optical circulators, the implementation of the function of spatial walk-off polarizers is a key technique that significantly influences the performance and cost of a device. This paper proposes a design of a multiport optical circulator by using polarizing beam splitter cubes as spatial walk-off polarizers. To show the feasibility of the design, a prototype of a six-port optical circulator was fabricated. The insertion losses are 0.94-1.49 dB, the isolations are 25-51 dB, and return losses are 27.72 dB.

A comparison of kinematic algorithms to estimate gait events during overground running.

PubMed

Smith, Laura; Preece, Stephen; Mason, Duncan; Bramah, Christopher

2015-01-01

The gait cycle is frequently divided into two distinct phases, stance and swing, which can be accurately determined from ground reaction force data. In the absence of such data, kinematic algorithms can be used to estimate footstrike and toe-off. The performance of previously published algorithms is not consistent between studies. Furthermore, previous algorithms have not been tested at higher running speeds nor used to estimate ground contact times. Therefore the purpose of this study was to both develop a new, custom-designed, event detection algorithm and compare its performance with four previously tested algorithms at higher running speeds. Kinematic and force data were collected on twenty runners during overground running at 5.6m/s. The five algorithms were then implemented and estimated times for footstrike, toe-off and contact time were compared to ground reaction force data. There were large differences in the performance of each algorithm. The custom-designed algorithm provided the most accurate estimation of footstrike (True Error 1.2 ± 17.1 ms) and contact time (True Error 3.5 ± 18.2 ms). Compared to the other tested algorithms, the custom-designed algorithm provided an accurate estimation of footstrike and toe-off across different footstrike patterns. The custom-designed algorithm provides a simple but effective method to accurately estimate footstrike, toe-off and contact time from kinematic data. Copyright © 2014 Elsevier B.V. All rights reserved.

PCR Amplicon Prediction from Multiplex Degenerate Primer and Probe Sets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gardner, S. N.

2013-08-08

Assessing primer specificity and predicting both desired and off-target amplification products is an essential step for robust PCR assay design. Code is described to predict potential polymerase chain reaction (PCR) amplicons in a large sequence database such as NCBI nt from either singleplex or a large multiplexed set of primers, allowing degenerate primer and probe bases, with target mismatch annotates amplicons with gene information automatically downloaded from NCBI, and optionally it can predict whether there are also TaqMan/Luminex probe matches within predicted amplicons.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liese, Eric; Zitney, Stephen E.

A multi-stage centrifugal compressor model is presented with emphasis on analyzing use of an exit flow coefficient vs. an inlet flow coefficient performance parameter to predict off-design conditions in the critical region of a supercritical carbon dioxide (CO 2) power cycle. A description of the performance parameters is given along with their implementation in a design model (number of stages, basic sizing, etc.) and a dynamic model (for use in transient studies). A design case is shown for two compressors, a bypass compressor and a main compressor, as defined in a process simulation of a 10 megawatt (MW) supercritical COmore » 2 recompression Brayton cycle. Simulation results are presented for a simple open cycle and closed cycle process with changes to the inlet temperature of the main compressor which operates near the CO 2 critical point. Results showed some difference in results using the exit vs. inlet flow coefficient correction, however, it was not significant for the range of conditions examined. Here, this paper also serves as a reference for future works, including a full process simulation of the 10 MW recompression Brayton cycle.« less

Computational Study of the Impact of Unsteadiness on the Aerodynamic Performance of a Variable- Speed Power Turbine

NASA Technical Reports Server (NTRS)

Welch, Gerard E.

2012-01-01

The design-point and off-design performance of an embedded 1.5-stage portion of a variable-speed power turbine (VSPT) was assessed using Reynolds-Averaged Navier-Stokes (RANS) analyses with mixing-planes and sector-periodic, unsteady RANS analyses. The VSPT provides one means by which to effect the nearly 50 percent main-rotor speed change required for the NASA Large Civil Tilt-Rotor (LCTR) application. The change in VSPT shaft-speed during the LCTR mission results in blade-row incidence angle changes of as high as 55 . Negative incidence levels of this magnitude at takeoff operation give rise to a vortical flow structure in the pressure-side cove of a high-turn rotor that transports low-momentum flow toward the casing endwall. The intent of the effort was to assess the impact of unsteadiness of blade-row interaction on the time-mean flow and, specifically, to identify potential departure from the predicted trend of efficiency with shaft-speed change of meanline and 3-D RANS/mixing-plane analyses used for design.

Description of CASCOMP Comprehensive Airship Sizing and Performance Computer Program, Volume 2

NASA Technical Reports Server (NTRS)

Davis, J.

1975-01-01

The computer program CASCOMP, which may be used in comparative design studies of lighter than air vehicles by rapidly providing airship size and mission performance data, was prepared and documented. The program can be used to define design requirements such as weight breakdown, required propulsive power, and physical dimensions of airships which are designed to meet specified mission requirements. The program is also useful in sensitivity studies involving both design trade-offs and performance trade-offs. The input to the program primarily consists of a series of single point values such as hull overall fineness ratio, number of engines, airship hull and empennage drag coefficients, description of the mission profile, and weights of fixed equipment, fixed useful load and payload. In order to minimize computation time, the program makes ample use of optional computation paths.

Trade-off Mechanisms Shaping the Diversity of Bacteria.

PubMed

Ferenci, Thomas

2016-03-01

Strain-to-strain variations in bacterial biofilm formation, metabolism, motility, virulence, evolvability, DNA repair and resistance (to phage, antibiotics, or environmental stresses) each contribute to bacterial diversity. Microbiologists should be aware that all of these traits are subject to constraints imposed by trade-offs, so adaptations improving one trait may be at the cost of another. A deeper appreciation of trade-offs is thus crucial for assessing the mechanistic limits on important bacterial characteristics. Studies of the negative correlations between various traits have revealed three molecular mechanisms, namely, trade-offs involving resource allocation, design constraint, and information processing. This review further discusses why these trade-off mechanisms are important in the establishment of models capable of predicting bacterial competition, coexistence, and sources of diversity. Copyright © 2015 Elsevier Ltd. All rights reserved.

Under What Conditions is Off-The-Job Stress a Significant Determinant of Occupational Behavior?

ERIC Educational Resources Information Center

Shostak, Arthur B.

1973-01-01

Through new attention to role expansion, physical environment design, hostility scalebacks, and information enlargement, we can make substantial new gains against off-the-job stresses that depress on-the-job performance. (Author)

Supersonic investigation of two dimensional hypersonic exhaust nozzles

NASA Technical Reports Server (NTRS)

Carboni, Jeanne D.; Shyne, Rickey J.; Leavitt, Laurence D.; Taylor, John G.; Lamb, Milton

1992-01-01

An experimental investigation was conducted in the NASA Lewis 10 x 10 ft supersonic Wind Tunnel to determine the performance characteristics of 2D hypersonic exhaust nozzles/afterbodies at low supersonic conditions. Generally, this type of application requires a single expansion ramp nozzle (SERN) that is highly integrated with the airframe of the hypersonic vehicle. At design conditions (hypersonic speeds), the nozzle generally exhibits acceptable performance. At off-design conditions (transonic to mid-supersonic speeds), nozzle performance of a fixed geometry configuration is generally poor. Various 2-D nozzle configurations were tested at off-design conditions from Mach 2.0 to 3.5. Performance data is presented at nozzle pressure ratios from 1 to 35. Jet exhaust was simulated with high-pressure air. To study performance of different geometries, nozzle configurations were varied by interchanging the following model parts: internal upstream contour, expansion ramp, sidewalls, and cowl.

Exploring NIR technique in rapid prediction of cotton trash components

USDA-ARS?s Scientific Manuscript database

Near infrared (NIR) spectroscopy, a useful technique due to the speed, ease of use, and adaptability to on-line or off-line implementation, has been applied to perform the qualitative classification and quantitative prediction on a number of cotton quality indices, including cotton trash from HVI, S...

The effect of on/off indicator design on state confusion, preference, and response time performance, executive summary

NASA Technical Reports Server (NTRS)

Donner, Kimberly A.; Holden, Kritina L.; Manahan, Meera K.

1991-01-01

Investigated are five designs of software-based ON/OFF indicators in a hypothetical Space Station Power System monitoring task. The hardware equivalent of the indicators used in the present study is the traditional indicator light that illuminates an ON label or an OFF label. Coding methods used to represent the active state were reverse video, color, frame, check, or reverse video with check. Display background color was also varied. Subjects made judgments concerning the state of indicators that resulted in very low error rates and high percentages of agreement across indicator designs. Response time measures for each of the five indicator designs did not differ significantly, although subjects reported that color was the best communicator. The impact of these results on indicator design is discussed.

Trade-off results and preliminary designs of Near-Term Hybrid Vehicles

NASA Technical Reports Server (NTRS)

Sandberg, J. J.

1980-01-01

Phase I of the Near-Term Hybrid Vehicle Program involved the development of preliminary designs of electric/heat engine hybrid passenger vehicles. The preliminary designs were developed on the basis of mission analysis, performance specification, and design trade-off studies conducted independently by four contractors. THe resulting designs involve parallel hybrid (heat engine/electric) propulsion systems with significant variation in component selection, power train layout, and control strategy. Each of the four designs is projected by its developer as having the potential to substitute electrical energy for 40% to 70% of the petroleum fuel consumed annually by its conventional counterpart.

Ti/Al Design/Cost Trade-Off Analysis

DTIC Science & Technology

1978-10-01

evaluate the applV!ati’an of selected titanium aluuinide alloys to both dynamic and static components of aircraft gas turbine engines . Mr. D. 0. Nash...the development of advanced aircraft gas turbine engines , a continuing objective has been to develop lightweight, high-performance designs. A parallel... engines for the design/cost trade-off study are as follows: Dynamic Components "* F1O1 Fourth-Stage Compressor Blade "* JlO1 Low Pressure Turbine Blade

Off-design performance of a chemical looping combustion (CLC) combined cycle: effects of ambient temperature

NASA Astrophysics Data System (ADS)

Chi, Jinling; Wang, Bo; Zhang, Shijie; Xiao, Yunhan

2010-02-01

The present work investigates the influence of ambient temperature on the steady-state off-design thermodynamic performance of a chemical looping combustion (CLC) combined cycle. A sensitivity analysis of the CLC reactor system was conducted, which shows that the parameters that influence the temperatures of the CLC reactors most are the flow rate and temperature of air entering the air reactor. For the ambient temperature variation, three off-design control strategies have been assumed and compared: 1) without any Inlet Guide Vane (IGV) control, 2) IGV control to maintain air reactor temperature and 3) IGV control to maintain constant fuel reactor temperature, aside from fuel flow rate adjusting. Results indicate that, compared with the conventional combined cycle, due to the requirement of pressure balance at outlet of the two CLC reactors, CLC combined cycle shows completely different off-design thermodynamic characteristics regardless of the control strategy adopted. For the first control strategy, temperatures of the two CLC reactors both rise obviously as ambient temperature increases. IGV control adopted by the second and the third strategy has the effect to maintain one of the two reactors' temperatures at design condition when ambient temperature is above design point. Compare with the second strategy, the third would induce more severe decrease of efficiency and output power of the CLC combined cycle.

Nuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome Editing

PubMed Central

Lee, Ciaran M; Cradick, Thomas J; Fine, Eli J; Bao, Gang

2016-01-01

The rapid advancement in targeted genome editing using engineered nucleases such as ZFNs, TALENs, and CRISPR/Cas9 systems has resulted in a suite of powerful methods that allows researchers to target any genomic locus of interest. A complementary set of design tools has been developed to aid researchers with nuclease design, target site selection, and experimental validation. Here, we review the various tools available for target selection in designing engineered nucleases, and for quantifying nuclease activity and specificity, including web-based search tools and experimental methods. We also elucidate challenges in target selection, especially in predicting off-target effects, and discuss future directions in precision genome editing and its applications. PMID:26750397

Prognostic value of preoperative serum CA 242 in Esophageal squamous cell carcinoma cases.

PubMed

Feng, Ji-Feng; Huang, Ying; Chen, Qi-Xun

2013-01-01

Carbohydrate antigen (CA) 242 is inversely related to prognosis in many cancers. However, few data regarding CA 242 in esophageal cancer (EC) are available. The aim of this study was to determine the prognostic value of CA 242 and propose an optimum cut-off point in predicting survival difference in patients with esophageal squamous cell carcinoma (ESCC). A retrospective analysis was conducted of 192 cases. A receiver operating characteristic (ROC) curve for survival prediction was plotted to verify the optimum cuf- off point. Univariate and multivariate analyses were performed to evaluate prognostic parameters for survival. The positive rate for CA 242 was 7.3% (14/192). The ROC curve for survival prediction gave an optimum cut-off of 2.15 (U/ml). Patients with CA 242 ≤ 2.15 U/ml had significantly better 5-year survival than patients with CA 242 >2.15 U/ml (45.4% versus 22.6%; P=0.003). Multivariate analysis showed that differentiation (P=0.033), CA 242 (P=0.017), T grade (P=0.004) and N staging (P<0.001) were independent prognostic factors. Preoperative CA 242 is a predictive factor for long-term survival in ESCC, especially in nodal-negative patients. We conclude that 2.15 U/ml may be the optimum cuf-off point for CA 242 in predicting survival in ESCC.

Calculation methods for steadily loaded, off-set pivot, tilting pad thrust bearings. (Guide to use of computer program A9235.)

NASA Astrophysics Data System (ADS)

1992-12-01

ESDU 92035 provides details of a FORTRAN program that implements the calculation method of ESDU 83004. It allows performance analysis of an existing design, or the design of a bearing dimensions, subject to any space constraint, are recommended. The predicted performance includes the lubricant film thickness under load, its temperature and flow rate, the power loss, and the bearing temperature. Recommendations are also made on surface finish. Warning messages are output in the following cases, for each of which possible remedial actions are suggested: drain or pad temperature too high, churning losses too great, film thickness too small, pad number too high, ratio or inner to outer pad radius too large, flow rate too great, lubricant or pad temperature outside usable range. A lubricant database is provided that may be extended or edited. The program applies to Newtonian lubricants in laminar flow. Worked examples illustrate the use of the program.

Robust spherical direct-drive design for NI

NASA Astrophysics Data System (ADS)

Masse, Laurent; Hurricane, O.; Michel, P.; Nora, R.; Tabak, M.; Lawrence Livermore Natl Lab Team

2016-10-01

Achieving ignition in a direct-drive or indirect-drive cryogenic implosion is a tremendous challenge. Both approaches need to deal with physic and technologic issues. During the past years, the indirect drive effort on the National Ignition Facility (NIF) has revealed unpredicted lost of performances that force to think to more robust designs and to dig into detailed physics aspects. Encouraging results have been obtained using a strong first shock during the implosion of CH ablator ignition capsules. These ``high-foot'' implosion results in a significantly lower ablation Rayleigh-Taylor instability growth than that of the NIC point design capsule. The trade-off with this design is a higher fuel adiabat that limits both fuel compression and theoretical capsule yield. The purpose of designing this capsule is to recover a more ideal one-dimensional implosion that is in closer agreement to simulation predictions. In the same spirit of spending energy on margin, at the coast of decreased performance, we are presenting here a study on ``robust'' spherical direct drive design for NIF. This 2-Shock direct drive pulse shape results in a high adiabat (>3) and low convergence (<17) implosion designed to produce a near 1D-like implosion. We take a particular attention to design a robust implosion with respect to long-wavelength non uniformity seeded by power imbalance and target offset. This work was performed under the auspices of the Lawrence Livermore National Security, LLC, (LLNS) under Contract No. DE-AC52-07NA27344.

Comparison of Computational and Experimental Results for a Transonic Variable-Speed Power-Turbine Blade Operating with Low Inlet Turbulence Levels

NASA Technical Reports Server (NTRS)

Booth, David; Flegel, Ashlie

2015-01-01

A computational assessment of the aerodynamic performance of the midspan section of a variable-speed power-turbine blade is described. The computation comprises a periodic single blade that represents the 2-D Midspan section VSPT blade that was tested in the NASA Glenn Research Center Transonic Turbine Blade Cascade Facility. A commercial, off-the-shelf (COTS) software package, Pointwise and CFD++, was used for the grid generation and RANS and URANS computations. The CFD code, which offers flexibility in terms of turbulence and transition modeling options, was assessed in terms of blade loading, loss, and turning against test data from the transonic tunnel. Simulations were assessed at positive and negative incidence angles that represent the turbine cruise and take-off design conditions. The results indicate that the secondary flow induced at the positive incidence cruise condition results in a highly loaded case and transitional flow on the blade is observed. The negative incidence take-off condition is unloaded and the flow is very two-dimensional. The computational results demonstrate the predictive capability of the gridding technique and COTS software for a linear transonic turbine blade cascade with large incidence angle variation.

Comparison of Computational and Experimental Results for a Transonic Variable-speed Power-Turbine Blade Operating with Low Inlet Turbulence Levels

NASA Technical Reports Server (NTRS)

Booth, David T.; Flegel, Ashlie B.

2015-01-01

A computational assessment of the aerodynamic performance of the midspan section of a variable-speed power-turbine blade is described. The computation comprises a periodic single blade that represents the 2-D Midspan section VSPT blade that was tested in the NASA Glenn Research Center Transonic Turbine Blade Cascade Facility. A commercial, off-the-shelf (COTS) software package, Pointwise and CFD++, was used for the grid generation and RANS and URANS computations. The CFD code, which offers flexibility in terms of turbulence and transition modeling options, was assessed in terms of blade loading, loss, and turning against test data from the transonic tunnel. Simulations were assessed at positive and negative incidence angles that represent the turbine cruise and take-off design conditions. The results indicate that the secondary flow induced at the positive incidence cruise condition results in a highly loaded case and transitional flow on the blade is observed. The negative incidence take-off condition is unloaded and the flow is very two-dimensional. The computational results demonstrate the predictive capability of the gridding technique and COTS software for a linear transonic turbine blade cascade with large incidence angle variation.

Analyzing Reliability and Performance Trade-Offs of HLS-Based Designs in SRAM-Based FPGAs Under Soft Errors

NASA Astrophysics Data System (ADS)

Tambara, Lucas Antunes; Tonfat, Jorge; Santos, André; Kastensmidt, Fernanda Lima; Medina, Nilberto H.; Added, Nemitala; Aguiar, Vitor A. P.; Aguirre, Fernando; Silveira, Marcilei A. G.

2017-02-01

The increasing system complexity of FPGA-based hardware designs and shortening of time-to-market have motivated the adoption of new designing methodologies focused on addressing the current need for high-performance circuits. High-Level Synthesis (HLS) tools can generate Register Transfer Level (RTL) designs from high-level software programming languages. These tools have evolved significantly in recent years, providing optimized RTL designs, which can serve the needs of safety-critical applications that require both high performance and high reliability levels. However, a reliability evaluation of HLS-based designs under soft errors has not yet been presented. In this work, the trade-offs of different HLS-based designs in terms of reliability, resource utilization, and performance are investigated by analyzing their behavior under soft errors and comparing them to a standard processor-based implementation in an SRAM-based FPGA. Results obtained from fault injection campaigns and radiation experiments show that it is possible to increase the performance of a processor-based system up to 5,000 times by changing its architecture with a small impact in the cross section (increasing up to 8 times), and still increasing the Mean Workload Between Failures (MWBF) of the system.

A diagnosis of bipolar spectrum disorder predicts diagnostic conversion from unipolar depression to bipolar disorder: a 5-year retrospective study.

PubMed

Woo, Young Sup; Shim, In Hee; Wang, Hee-Ryung; Song, Hoo Rim; Jun, Tae-Youn; Bahk, Won-Myong

2015-03-15

The major aims of this study were to identify factors that may predict the diagnostic conversion from major depressive disorder (MDD) to bipolar disorder (BP) and to evaluate the predictive performance of the bipolar spectrum disorder (BPSD) diagnostic criteria. The medical records of 250 patients with a diagnosis of MDD for at least 5 years were retrospectively reviewed for this study. The diagnostic conversion from MDD to BP was observed in 18.4% of 250 MDD patients, and the diagnostic criteria for BPSD predicted this conversion with high sensitivity (0.870) and specificity (0.917). A family history of BP, antidepressant-induced mania/hypomania, brief major depressive episodes, early age of onset, antidepressant wear-off, and antidepressant resistance were also independent predictors of this conversion. This study was conducted using a retrospective design and did not include structured diagnostic interviews. The diagnostic criteria for BPSD were highly predictive of the conversion from MDD to BP, and conversion was associated with several clinical features of BPSD. Thus, the BPSD diagnostic criteria may be useful for the prediction of bipolar diathesis in MDD patients. Copyright © 2014 Elsevier B.V. All rights reserved.

Towing tests of models as an aid in the design of seaplanes

NASA Technical Reports Server (NTRS)

Schroder, P

1932-01-01

This report concerns the making and evaluation of a towing test of a seaplane float system. Some of the topics considered are: 1) the influence of the wing cell and power plant on the take-off performance; 2) the determination of the resistance curve for the take-off free to trim; 3) the resistance curves with elevator control (at fixed trims); 4) take-off time and take-off run.

Multiple scattering theory for total skin electron beam design.

PubMed

Antolak, J A; Hogstrom, K R

1998-06-01

The purpose of this manuscript is to describe a method for designing a broad beam of electrons suitable for total skin electron irradiation (TSEI). A theoretical model of a TSEI beam from a linear accelerator with a dual scattering system has been developed. The model uses Fermi-Eyges theory to predict the planar fluence of the electron beam after it has passed through various materials between the source and the treatment plane, which includes scattering foils, monitor chamber, air, and a plastic diffusing plate. Unique to this model is its accounting for removal of the tails of the electron beam profile as it passes through the primary x-ray jaws. A method for calculating the planar fluence profile for an obliquely incident beam is also described. Off-axis beam profiles and percentage depth doses are measured with ion chambers, film, and thermoluminescent dosimeters (TLD). The measured data show that the theoretical model can accurately predict beam energy and planar fluence of the electron beam at normal and oblique incidence. The agreement at oblique angles is not quite as good but is sufficiently accurate to be of predictive value when deciding on the optimal angles for the clinical TSEI beams. The advantage of our calculational approach for designing a TSEI beam is that many different beam configurations can be tested without having to perform time-consuming measurements. Suboptimal configurations can be quickly dismissed, and the predicted optimal solution should be very close to satisfying the clinical specifications.

Can we do better than the grid survey: Optimal synoptic surveys in presence of variable uncertainty and decorrelation scales

NASA Astrophysics Data System (ADS)

Frolov, Sergey; Garau, Bartolame; Bellingham, James

2014-08-01

Regular grid ("lawnmower") survey is a classical strategy for synoptic sampling of the ocean. Is it possible to achieve a more effective use of available resources if one takes into account a priori knowledge about variability in magnitudes of uncertainty and decorrelation scales? In this article, we develop and compare the performance of several path-planning algorithms: optimized "lawnmower," a graph-search algorithm (A*), and a fully nonlinear genetic algorithm. We use the machinery of the best linear unbiased estimator (BLUE) to quantify the ability of a vehicle fleet to synoptically map distribution of phytoplankton off the central California coast. We used satellite and in situ data to specify covariance information required by the BLUE estimator. Computational experiments showed that two types of sampling strategies are possible: a suboptimal space-filling design (produced by the "lawnmower" and the A* algorithms) and an optimal uncertainty-aware design (produced by the genetic algorithm). Unlike the space-filling designs that attempted to cover the entire survey area, the optimal design focused on revisiting areas of high uncertainty. Results of the multivehicle experiments showed that fleet performance predictors, such as cumulative speed or the weight of the fleet, predicted the performance of a homogeneous fleet well; however, these were poor predictors for comparing the performance of different platforms.

Preliminary design trade-offs for a multi-mission stored cryogen cooler

NASA Technical Reports Server (NTRS)

Sherman, A.

1978-01-01

Preliminary design studies were performed for a multi-mission solid cryogen cooler having a wide range of application for both the shuttle sortie and free flyer missions. This multi-mission cooler (MMC) is designed to be utilized with various solid cryogens to meet a wide range of instrument cooling from 10 K (with solid hydrogen) to 90 K. The baseline cooler utilizes two stages of solid cryogen and incorporates an optional, higher temperature third stage which is cooled by either a passive radiator or a thermoelectric cooler. The MMC has an interface which can accommodate a wide variety of instrument configurations. A shrink fit adapter is incorporated which allows a drop-in instrument integration. The baseline design provides cooling of approximately 1 watt over a 60 to 100 K temperature range and about 0.5 watts from 15 to 60 K for a one year lifetime. For low cooling loads and with use of the optional radiator shield, cooling lifetimes as great as 8 years are predicted.

Modelling field scale spatial variation in water run-off, soil moisture, N2O emissions and herbage biomass of a grazed pasture using the SPACSYS model.

PubMed

Liu, Yi; Li, Yuefen; Harris, Paul; Cardenas, Laura M; Dunn, Robert M; Sint, Hadewij; Murray, Phil J; Lee, Michael R F; Wu, Lianhai

2018-04-01

In this study, we evaluated the ability of the SPACSYS model to simulate water run-off, soil moisture, N 2 O fluxes and grass growth using data generated from a field of the North Wyke Farm Platform. The field-scale model is adapted via a linked and grid-based approach (grid-to-grid) to account for not only temporal dynamics but also the within-field spatial variation in these key ecosystem indicators. Spatial variability in nutrient and water presence at the field-scale is a key source of uncertainty when quantifying nutrient cycling and water movement in an agricultural system. Results demonstrated that the new spatially distributed version of SPACSYS provided a worthy improvement in accuracy over the standard (single-point) version for biomass productivity. No difference in model prediction performance was observed for water run-off, reflecting the closed-system nature of this variable. Similarly, no difference in model prediction performance was found for N 2 O fluxes, but here the N 2 O predictions were noticeably poor in both cases. Further developmental work, informed by this study's findings, is proposed to improve model predictions for N 2 O. Soil moisture results with the spatially distributed version appeared promising but this promise could not be objectively verified.

Optical mounts for harsh environments

NASA Astrophysics Data System (ADS)

Mimovich, Mark E.; Griffee, Jonathan C.; Goodding, James C.

2009-08-01

Development and testing of a lightweight-kinematic optical mount with integrated passive vibration-and-shock mitigation technologies and simple / robust optical alignment functionality is presented. Traditionally, optical mounts are designed for use in laboratory environments where the thermal-mechanical environments are carefully controlled to preserve beam path conditions and background disturbances are minimized to facilitate precise optically based measurements. Today's weapon and surveillance systems, however, have optical sensor suites where static and dynamic alignment performance in the presence of harsh operating environments is required to nearly the same precision and where the system cannot afford the mass of laboratory-grade stabilized mounting systems. Jitter and alignment stability is particularly challenging for larger optics operating within moving vehicles and aircraft where high shock and significant temperature excursions occur. The design intent is to have the mount be suitable for integration into existing defense and security optical systems while also targeting new commercial and military components for improved structural dynamic and thermal distortion performance. A mount suitable for moderate-sized optics and an integrated disturbance-optical metrology system are described. The mount design has performance enhancements derived from the integration of proven aerospace mechanical vibration and shock mitigation technologies (i.e. multi-axis passive isolation and integral damping), precision alignment adjustment and lock-out functionality, high dimensional stability materials and design practices which provide benign optical surface figure errors under harsh thermal-mechanical loading. Optical jitter, alignment, and wave-front performance testing of an eight-inch-aperture optical mount based on this design approach are presented to validate predicted performance improvements over an existing commercial off-the-shelf (COTS) design.

Concept and performance study of turbocharged solid propellant ramjet

NASA Astrophysics Data System (ADS)

Li, Jiang; Liu, Kai; Liu, Yang; Liu, Shichang

2018-06-01

This study proposes a turbocharged solid propellant ramjet (TSPR) propulsion system that integrates a turbocharged system consisting of a solid propellant (SP) air turbo rocket (ATR) and the fuel-rich gas generator of a solid propellant ramjet (SPR). First, a suitable propellant scheme was determined for the TSPR. A solid hydrocarbon propellant is used to generate gas for driving the turbine, and a boron-based fuel-rich propellant is used to provide fuel-rich gas to the afterburner. An appropriate TSPR structure was also determined. The TSPR's thermodynamic cycle was analysed to prove its theoretical feasibility. The results showed that the TSPR's specific cycle power was larger than those of SP-ATR and SPR and thermal efficiency was slightly less than that of SP-ATR. Overall, TSPR showed optimal performance in a wide flight envelope. The specific impulses and specific thrusts of TSPR, SP-ATR, and SPR in the flight envelope were calculated and compared. TSPR's flight envelope roughly overlapped that of SP-ATR, its specific impulse was larger than that of SP-ATR, and its specific thrust was larger than those of SP-ATR and SPR. Attempts to improve the TSPR off-design performance prompted our proposal of a control plan for off-design codes in which both the turbocharger corrected speed and combustor excess gas coefficient are kept constant. An off-design performance model was established by analysing the TSPR working process. We concluded that TSPR with a constant corrected speed had wider flight envelope, higher thrust, and higher specific impulse than TSPR with a constant physical speed determined by calculating the performance of off-design TSPR codes under different control plans. The results of this study can provide a reference for further studies on TSPRs.

Designing multi-reservoir system designs via efficient water-energy-food nexus trade-offs - Selecting new hydropower dams for the Blue Nile and Nepal's Koshi Basin

NASA Astrophysics Data System (ADS)

Harou, J. J.; Hurford, A.; Geressu, R. T.

2015-12-01

Many of the world's multi-reservoir water resource systems are being considered for further development of hydropower and irrigation aiming to meet economic, political and ecological goals. Complex river basins serve many needs so how should the different proposed groupings of reservoirs and their operations be evaluated? How should uncertainty about future supply and demand conditions be factored in? What reservoir designs can meet multiple goals and perform robustly in a context of global change? We propose an optimized multi-criteria screening approach to identify best performing designs, i.e., the selection, size and operating rules of new reservoirs within multi-reservoir systems in a context of deeply uncertain change. Reservoir release operating rules and storage sizes are optimized concurrently for each separate infrastructure design under consideration across many scenarios representing plausible future conditions. Outputs reveal system trade-offs using multi-dimensional scatter plots where each point represents an approximately Pareto-optimal design. The method is applied to proposed Blue Nile River reservoirs in Ethiopia, where trade-offs between capital costs, total and firm energy output, aggregate storage and downstream irrigation and energy provision for the best performing designs are evaluated. The impact of filling period for large reservoirs is considered in a context of hydrological uncertainty. The approach is also applied to the Koshi basin in Nepal where combinations of hydropower storage and run-of-river dams are being considered for investment. We show searching for investment portfolios that meet multiple objectives provides stakeholders with a rich view on the trade-offs inherent in the nexus and how different investment bundles perform differently under plausible futures. Both case-studies show how the proposed approach helps explore and understand the implications of investing in new dams in a global change context.

Trade-off study and computer simulation for assessing spacecraft pointing accuracy and stability capabilities

NASA Astrophysics Data System (ADS)

Algrain, Marcelo C.; Powers, Richard M.

1997-05-01

A case study, written in a tutorial manner, is presented where a comprehensive computer simulation is developed to determine the driving factors contributing to spacecraft pointing accuracy and stability. Models for major system components are described. Among them are spacecraft bus, attitude controller, reaction wheel assembly, star-tracker unit, inertial reference unit, and gyro drift estimators (Kalman filter). The predicted spacecraft performance is analyzed for a variety of input commands and system disturbances. The primary deterministic inputs are the desired attitude angles and rate set points. The stochastic inputs include random torque disturbances acting on the spacecraft, random gyro bias noise, gyro random walk, and star-tracker noise. These inputs are varied over a wide range to determine their effects on pointing accuracy and stability. The results are presented in the form of trade- off curves designed to facilitate the proper selection of subsystems so that overall spacecraft pointing accuracy and stability requirements are met.

Pre-PDK block-level PPAC assessment of technology options for sub-7nm high-performance logic

NASA Astrophysics Data System (ADS)

Liebmann, L.; Northrop, G.; Facchini, M.; Riviere Cazaux, L.; Baum, Z.; Nakamoto, N.; Sun, K.; Chanemougame, D.; Han, G.; Gerousis, V.

2018-03-01

This paper describes a rigorous yet flexible standard cell place-and-route flow that is used to quantify block-level power, performance, and area trade-offs driven by two unique cell architectures and their associated design rule differences. The two architectures examined in this paper differ primarily in their use of different power-distribution-networks to achieve the desired circuit performance for high-performance logic designs. The paper shows the importance of incorporating block-level routability experiments in the early phases of design-technology co-optimization by reviewing a series of routing trials that explore different aspects of the technology definition. Since the electrical and physical parameters leading to critical process assumptions and design rules are unique to specific integration schemes and design objectives, it is understood that the goal of this work is not to promote one cell-architecture over another, but rather to convey the importance of exploring critical trade-offs long before the process details of the technology node are finalized to a point where a process design kit can be published.

Analysis of the faster-than-Nyquist optimal linear multicarrier system

NASA Astrophysics Data System (ADS)

Marquet, Alexandre; Siclet, Cyrille; Roque, Damien

2017-02-01

Faster-than-Nyquist signalization enables a better spectral efficiency at the expense of an increased computational complexity. Regarding multicarrier communications, previous work mainly relied on the study of non-linear systems exploiting coding and/or equalization techniques, with no particular optimization of the linear part of the system. In this article, we analyze the performance of the optimal linear multicarrier system when used together with non-linear receiving structures (iterative decoding and direct feedback equalization), or in a standalone fashion. We also investigate the limits of the normality assumption of the interference, used for implementing such non-linear systems. The use of this optimal linear system leads to a closed-form expression of the bit-error probability that can be used to predict the performance and help the design of coded systems. Our work also highlights the great performance/complexity trade-off offered by decision feedback equalization in a faster-than-Nyquist context. xml:lang="fr"

Design trade-off and proof of concept for LOUPE, the Lunar Observatory for Unresolved Polarimetry of Earth.

PubMed

Hoeijmakers, H J; Arts, M L J; Snik, F; Keller, C U; Kuiper, J M

2016-09-19

We provide a proof of the technical feasibility of LOUPE, the first integral-field snapshot spectropolarimeter, designed to monitor the reflected flux and polarization spectrum of Earth. These are to be used as benchmark data for the retrieval of biomarkers and atmospheric and surface characteristics from future direct observations of exoplanets. We perform a design trade-off for an implementation in which LOUPE performs snapshot integral-field spectropolarimetry at visible wavelengths. We used off-the-shelf optics to construct a polarization modulator, in which polarization information is encoded into the spectrum as a wavelength-dependent modulation, while spatial resolution is maintained using a micro-lens array. The performance of this design concept is validated in a laboratory setup. Our proof-of-concept is capable of measuring a grid of 50 × 50 polarization spectra between 610 and 780 nm of a mock target planet - proving the merit of this design. The measurements are affected by systematic noise on the percent level, and we discuss how to mitigate this in future iterations. We conclude that LOUPE can be small and robust while meeting the science goals of this particular space application, and note the many potential applications that may benefit from our concept for doing snapshot integral-field spectropolarimetry.

Serological Tests Do Not Predict Residual Fibrosis in Hepatitis C Cirrhotics with a Sustained Virological Response to Interferon.

PubMed

D'Ambrosio, Roberta; Degasperi, Elisabetta; Aghemo, Alessio; Fraquelli, Mirella; Lampertico, Pietro; Rumi, Maria Grazia; Facchetti, Floriana; Grassi, Eleonora; Casazza, Giovanni; Rosenberg, William; Bedossa, Pierre; Colombo, Massimo

2016-01-01

Liver biopsy (LB) has lost popularity to stage liver fibrosis in the era of highly effective anti-hepatitis C virus (HCV) therapy, yet diagnosis of persistent cirrhosis may have important implications following HCV eradication. As performance of serological non-invasive tests (NITs) to predict residual fibrosis in non-viremic HCV patients is unknown, we investigated accuracy of NITs to predict residual fibrosis in cirrhotics after a sustained virological response (SVR) to interferon (IFN). Thirty-eight patients with a pre-treatment histological diagnosis of cirrhosis and a 48-104 months post-SVR LB were tested with APRI, CDS, FIB-4, FibroQ, Forns Score, GUCI Index, King Score, Lok Index, PLF, ELF. In 23 (61%) patients, cirrhosis had histologically regressed. All NITs values declined after SVR without any significant difference between regressors and non-regressors (AUROC 0.52-0.75). Using viremic cut-offs, PPV ranged from 34% to 100%, with lower NPV (63% - 68%). NITs performance did not improve using derived cut-offs (PPV: 40% - 80%; NPV: 66% - 100%). PLF, which combines several NITs with transient elastography, had the best diagnostic performance (AUROC 0.75, Sn 61%, Sp 90%, PPV 80%, NPV 78%). After treatment, none of the NITs resulted significantly associated with any of the histological features (activity grade, fibrosis stage, area of fibrosis). The diagnostic estimates obtained using both viremic and derived cut-off values of NITs were suboptimal, indicating that none of these tests helps predicting residual fibrosis and that LB remains the gold standard for this purpose.

A two-dimensional matrix correction for off-axis portal dose prediction errors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bailey, Daniel W.; Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263; Kumaraswamy, Lalith

2013-05-15

Purpose: This study presents a follow-up to a modified calibration procedure for portal dosimetry published by Bailey et al. ['An effective correction algorithm for off-axis portal dosimetry errors,' Med. Phys. 36, 4089-4094 (2009)]. A commercial portal dose prediction system exhibits disagreement of up to 15% (calibrated units) between measured and predicted images as off-axis distance increases. The previous modified calibration procedure accounts for these off-axis effects in most regions of the detecting surface, but is limited by the simplistic assumption of radial symmetry. Methods: We find that a two-dimensional (2D) matrix correction, applied to each calibrated image, accounts for off-axismore » prediction errors in all regions of the detecting surface, including those still problematic after the radial correction is performed. The correction matrix is calculated by quantitative comparison of predicted and measured images that span the entire detecting surface. The correction matrix was verified for dose-linearity, and its effectiveness was verified on a number of test fields. The 2D correction was employed to retrospectively examine 22 off-axis, asymmetric electronic-compensation breast fields, five intensity-modulated brain fields (moderate-high modulation) manipulated for far off-axis delivery, and 29 intensity-modulated clinical fields of varying complexity in the central portion of the detecting surface. Results: Employing the matrix correction to the off-axis test fields and clinical fields, predicted vs measured portal dose agreement improves by up to 15%, producing up to 10% better agreement than the radial correction in some areas of the detecting surface. Gamma evaluation analyses (3 mm, 3% global, 10% dose threshold) of predicted vs measured portal dose images demonstrate pass rate improvement of up to 75% with the matrix correction, producing pass rates that are up to 30% higher than those resulting from the radial correction technique alone. As in the 1D correction case, the 2D algorithm leaves the portal dosimetry process virtually unchanged in the central portion of the detector, and thus these correction algorithms are not needed for centrally located fields of moderate size (at least, in the case of 6 MV beam energy).Conclusion: The 2D correction improves the portal dosimetry results for those fields for which the 1D correction proves insufficient, especially in the inplane, off-axis regions of the detector. This 2D correction neglects the relatively smaller discrepancies that may be caused by backscatter from nonuniform machine components downstream from the detecting layer.« less

Plateletpheresis efficiency and mathematical correction of software-derived platelet yield prediction: A linear regression and ROC modeling approach.

PubMed

Jaime-Pérez, José Carlos; Jiménez-Castillo, Raúl Alberto; Vázquez-Hernández, Karina Elizabeth; Salazar-Riojas, Rosario; Méndez-Ramírez, Nereida; Gómez-Almaguer, David

2017-10-01

Advances in automated cell separators have improved the efficiency of plateletpheresis and the possibility of obtaining double products (DP). We assessed cell processor accuracy of predicted platelet (PLT) yields with the goal of a better prediction of DP collections. This retrospective proof-of-concept study included 302 plateletpheresis procedures performed on a Trima Accel v6.0 at the apheresis unit of a hematology department. Donor variables, software predicted yield and actual PLT yield were statistically evaluated. Software prediction was optimized by linear regression analysis and its optimal cut-off to obtain a DP assessed by receiver operating characteristic curve (ROC) modeling. Three hundred and two plateletpheresis procedures were performed; in 271 (89.7%) occasions, donors were men and in 31 (10.3%) women. Pre-donation PLT count had the best direct correlation with actual PLT yield (r = 0.486. P < .001). Means of software machine-derived values differed significantly from actual PLT yield, 4.72 × 10 11 vs.6.12 × 10 11 , respectively, (P < .001). The following equation was developed to adjust these values: actual PLT yield= 0.221 + (1.254 × theoretical platelet yield). ROC curve model showed an optimal apheresis device software prediction cut-off of 4.65 × 10 11 to obtain a DP, with a sensitivity of 82.2%, specificity of 93.3%, and an area under the curve (AUC) of 0.909. Trima Accel v6.0 software consistently underestimated PLT yields. Simple correction derived from linear regression analysis accurately corrected this underestimation and ROC analysis identified a precise cut-off to reliably predict a DP. © 2016 Wiley Periodicals, Inc.

Design trade-offs among shunt current, pumping loss and compactness in the piping system of a multi-stack vanadium flow battery

NASA Astrophysics Data System (ADS)

Ye, Qiang; Hu, Jing; Cheng, Ping; Ma, Zhiqi

2015-11-01

Trade-off between shunt current loss and pumping loss is a major challenge in the design of the electrolyte piping network in a flow battery system. It is generally recognized that longer and thinner ducts are beneficial to reduce shunt current but detrimental to minimize pumping power. Base on the developed analog circuit model and the flow network model, we make case studies of multi-stack vanadium flow battery piping systems and demonstrate that both shunt current and electrolyte flow resistance can be simultaneously minimized by using longer and thicker ducts in the piping network. However, extremely long and/or thick ducts lead to a bulky system and may be prohibited by the stack structure. Accordingly, the intrinsic design trade-off is between system efficiency and compactness. Since multi-stack configurations bring both flexibility and complexity to the design process, we perform systematic comparisons among representative piping system designs to illustrate the complicated trade-offs among numerous parameters including stack number, intra-stack channel resistance and inter-stack pipe resistance. As the final design depends on various technical and economical requirements, this paper aims to provide guidelines rather than solutions for designers to locate the optimal trade-off points according to their specific cases.

Research on the performance of low-lift diving tubular pumping system by CFD and Test

NASA Astrophysics Data System (ADS)

Xia, Chenzhi; Cheng, Li; Liu, Chao; Zhou, Jiren; Tang, Fangping; Jin, Yan

2016-11-01

Post-diving tubular pump is always used in large-discharge & low-head irrigation or storm drainage pumping station, its impeller and motor share the same shaft. Considering diving tubular pump system's excellent hydraulic performance, compact structure, good noise resistance and low operating cost, it is used in Chinese pump stations. To study the hydraulic performance and pressure fluctuation of inlet and outlet passage in diving tubular pump system, both of steady and unsteady full flow fields are numerically simulated at three flow rate conditions by using CFD commercial software. The asymmetry of the longitudinal structure of inlet passage affects the flow pattern on outlet. Especially at small flow rate condition, structural asymmetry will result in the uneven velocity distribution on the outlet of passage inlet. The axial velocity distribution uniformity increases as the flow rate increases on the inlet of passage inlet, and there is a positive correlation between hydraulic loss in the passage inlet and flow rate's quadratic. The axial velocity distribution uniformity on the outlet of passage inlet is 90% at design flow rate condition. The predicted result shows the same trend with test result, and the range of high efficiency area between predicted result and test result is almost identical. The dominant frequency of pressure pulsation is low frequency in inlet passage at design condition. The dominant frequency is high frequency in inlet passage at small and large flow rate condition. At large flow rate condition, the flow pattern is significantly affected by the rotation of impeller in inlet passage. At off-design condition, the pressure pulsation is strong at outlet passage. At design condition, the dominant frequency is 35.57Hz, which is double rotation frequency.

A Methodology to Assess the Capability of Engine Designs to Meet Closed-Loop Performance and Operability Requirements

NASA Technical Reports Server (NTRS)

Zinnecker, Alicia M.; Csank, Jeffrey

2015-01-01

Designing a closed-loop controller for an engine requires balancing trade-offs between performance and operability of the system. One such trade-off is the relationship between the 95 percent response time and minimum high-pressure compressor (HPC) surge margin (SM) attained during acceleration from idle to takeoff power. Assuming a controller has been designed to meet some specification on response time and minimum HPC SM for a mid-life (nominal) engine, there is no guarantee that these limits will not be violated as the engine ages, particularly as it reaches the end of its life. A characterization for the uncertainty in this closed-loop system due to aging is proposed that defines elliptical boundaries to estimate worst-case performance levels for a given control design point. The results of this characterization can be used to identify limiting design points that bound the possible controller designs yielding transient results that do not exceed specified limits in response time or minimum HPC SM. This characterization involves performing Monte Carlo simulation of the closed-loop system with controller constructed for a set of trial design points and developing curve fits to describe the size and orientation of each ellipse; a binary search procedure is then employed that uses these fits to identify the limiting design point. The method is demonstrated through application to a generic turbofan engine model in closed-loop with a simplified controller; it is found that the limit for which each controller was designed was exceeded by less than 4.76 percent. Extension of the characterization to another trade-off, that between the maximum high-pressure turbine (HPT) entrance temperature and minimum HPC SM, showed even better results: the maximum HPT temperature was estimated within 0.76 percent. Because of the accuracy in this estimation, this suggests another limit that may be taken into consideration during design and analysis. It also demonstrates the extension of the characterization to other attributes that contribute to the performance or operability of the engine. Metrics are proposed that, together, provide information on the shape of the trade-off between response time and minimum HPC SM, and how much each varies throughout the life cycle, at the limiting design points. These metrics also facilitate comparison of the expected transient behavior for multiple engine models.

A Methodology to Assess the Capability of Engine Designs to Meet Closed-loop Performance and Operability Requirements

NASA Technical Reports Server (NTRS)

Zinnecker, Alicia M.; Csank, Jeffrey T.

2015-01-01

Designing a closed-loop controller for an engine requires balancing trade-offs between performance and operability of the system. One such trade-off is the relationship between the 95% response time and minimum high-pressure compressor (HPC) surge margin (SM) attained during acceleration from idle to takeoff power. Assuming a controller has been designed to meet some specification on response time and minimum HPC SM for a mid-life (nominal) engine, there is no guarantee that these limits will not be violated as the engine ages, particularly as it reaches the end of its life. A characterization for the uncertainty in this closed-loop system due to aging is proposed that defines elliptical boundaries to estimate worst-case performance levels for a given control design point. The results of this characterization can be used to identify limiting design points that bound the possible con- troller designs yielding transient results that do not exceed specified limits in response time or minimum HPC SM. This characterization involves performing Monte Carlo simulation of the closed-loop system with controller constructed for a set of trial design points and developing curve fits to describe the size and orientation of each ellipse; a binary search procedure is then employed that uses these fits to identify the limiting design point. The method is demonstrated through application to a generic turbofan engine model in closed- loop with a simplified controller; it is found that the limit for which each controller was designed was exceeded by less than 4.76%. Extension of the characterization to another trade-off, that between the maximum high-pressure turbine (HPT) entrance temperature and minimum HPC SM, showed even better results: the maximum HPT temperature was estimated within 0.76%. Because of the accuracy in this estimation, this suggests another limit that may be taken into consideration during design and analysis. It also demonstrates the extension of the characterization to other attributes that contribute to the performance or operability of the engine. Metrics are proposed that, together, provide information on the shape of the trade-off between response time and minimum HPC SM, and how much each varies throughout the life cycle, at the limiting design points. These metrics also facilitate comparison of the expected transient behavior for multiple engine models.

Water Flow Performance of a Superscale Model of the Fastrac Liquid Oxygen Pump

NASA Technical Reports Server (NTRS)

Skelley, Stephen; Zoladz, Thomas

1999-01-01

As part of the National Aeronautics and Space Administration's ongoing effort to lower the cost of access to space, the Marshall Space Flight Center has developed a rocket engine with 60,000 pounds of thrust for use on the Reusable Launch Vehicle technology demonstrator slated for launch in 2000. This gas generator cycle engine, known as the Fastrac engine, uses liquid oxygen and RP-1 for propellants and includes single stage liquid oxygen and RP-1 pumps and a single stage supersonic turbine on a common shaft. The turbopump design effort included the first use and application of new suction capability prediction codes and three-dimensional blade generation codes in an attempt to reduce the turbomachinery design and certification costs typically associated with rocket engine development. To verify the pump's predicted cavitation performance, a water flow test of a superscale model of the Fastrac liquid oxygen pump was conducted to experimentally evaluate the liquid oxygen pump's performance at and around the design point. The water flow test article replicated the flow path of the Fastrac liquid oxygen pump in a 1.582x scale model, including scaled seal clearances for correct leakage flow at a model operating speed of 5000 revolutions per minute. Flow entered the 3-blade axial-flow inducer, transitioned to a shrouded, 6-blade radial impeller, and discharged into a vaneless radial diffuser and collection volute. The test article included approximately 50 total and static pressure measurement locations as well as flush-mounted, high frequency pressure transducers for complete mapping of the pressure environment. The primary objectives of the water flow test were to measure the steady-state and dynamic pressure environment of the liquid oxygen pump versus flow coefficient, suction specific speed, and back face leakage flow rate. Results showed excellent correlation between the predicted and experimentally measured pump head rise at low suction specific speeds. Likewise, only small circumferential variations in steady-state impeller exit and radial diffuser pressure distributions were observed from 80% to 120% of the design flow coefficient, matching the computational predictions and confirming that the integrated design approach has minimized any exit volute-induced distortions. The test article exhibited suction performance trends typically observed in inducer designs with virtually constant head rise with decreasing inlet pressure until complete pump head breakdown. Unfortunately, the net positive suction head at 3% head fall-off occurred far below that predicted at all tested flow coefficients, resulting in a negative net positive suction head margin at the design point in water. Additional testing to map the unsteady pressure environment was conducted and interesting rotating phenomena at the inducer inlet were observed. These rotating phenomena's cell numbers, direction, and speed were correlated with pump operating parameters. The impact of the unsteady phenomena and their corresponding energy losses on the unexpectedly poor pump performance is also discussed.

ANL/RBC: A computer code for the analysis of Rankine bottoming cycles, including system cost evaluation and off-design performance

NASA Technical Reports Server (NTRS)

Mclennan, G. A.

1986-01-01

This report describes, and is a User's Manual for, a computer code (ANL/RBC) which calculates cycle performance for Rankine bottoming cycles extracting heat from a specified source gas stream. The code calculates cycle power and efficiency and the sizes for the heat exchangers, using tabular input of the properties of the cycle working fluid. An option is provided to calculate the costs of system components from user defined input cost functions. These cost functions may be defined in equation form or by numerical tabular data. A variety of functional forms have been included for these functions and they may be combined to create very general cost functions. An optional calculation mode can be used to determine the off-design performance of a system when operated away from the design-point, using the heat exchanger areas calculated for the design-point.

APS-U LATTICE DESIGN FOR OFF-AXIS ACCUMULATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, Yipeng; Borland, M.; Lindberg, R.

2017-06-25

A 67-pm hybrid-seven-bend achromat (H7BA) lattice is being proposed for a future Advanced Photon Source (APS) multi-bend-achromat (MBA) upgrade project. This lattice design pushes for smaller emittance and requires use of a swap-out (on-axis) injection scheme due to limited dynamic acceptance. Alternate lattice design work has also been performed for the APS upgrade to achieve better beam dynamics performance than the nominal APS MBA lattice, in order to allow off-axis accumulation. Two such alternate H7BA lattice designs, which target a still-low emittance of 90 pm, are discussed in detail in this paper. Although the single-particle-dynamics performance is good, simulations ofmore » collective effects indicate that surprising difficulty would be expected accumulating high single-bunch charge in this lattice. The brightness of the 90-pm lattice is also a factor of two lower than the 67-pm H7BA lattice.« less

Competitive assessment of aerospace systems using system dynamics

NASA Astrophysics Data System (ADS)

Pfaender, Jens Holger

Aircraft design has recently experienced a trend away from performance centric design towards a more balanced approach with increased emphasis on engineering an economically successful system. This approach focuses on bringing forward a comprehensive economic and life-cycle cost analysis. Since the success of any system also depends on many external factors outside of the control of the designer, this traditionally has been modeled as noise affecting the uncertainty of the design. However, this approach is currently lacking a strategic treatment of necessary early decisions affecting the probability of success of a given concept in a dynamic environment. This suggests that the introduction of a dynamic method into a life-cycle cost analysis should allow the analysis of the future attractiveness of such a concept in the presence of uncertainty. One way of addressing this is through the use of a competitive market model. However, existing market models do not focus on the dynamics of the market. Instead, they focus on modeling and predicting market share through logit regression models. The resulting models exhibit relatively poor predictive capabilities. The method proposed here focuses on a top-down approach that integrates a competitive model based on work in the field of system dynamics into the aircraft design process. Demonstrating such integration is one of the primary contributions of this work, which previously has not been demonstrated. This integration is achieved through the use of surrogate models, in this case neural networks. This enabled not only the practical integration of analysis techniques, but also reduced the computational requirements so that interactive exploration as envisioned was actually possible. The example demonstration of this integration is built on the competition in the 250 seat large commercial aircraft market exemplified by the Boeing 767-400ER and the Airbus A330-200. Both aircraft models were calibrated to existing performance and certification data and then integrated into the system dynamics market model. The market model was then calibrated with historical market data. This calibration showed a much improved predictive capability as compared to the conventional logit regression models. An additional advantage of this dynamic model is that to realize this improved capability, no additional explanatory variables were required. Furthermore, the resulting market model was then integrated into a prediction profiler environment with a time variant Monte-Carlo analysis resulting in a unique trade-off environment. This environment was shown to allow interactive trade-off between aircraft design decisions and economic considerations while allowing the exploration potential market success in the light of varying external market conditions and scenarios. The resulting method is capable of reduced decision support uncertainty and identification of robust design decisions in future scenarios with a high likelihood of occurrence with special focus on the path dependent nature of future implications of decisions. Furthermore, it was possible to demonstrate the increased importance of design and technology choices on the competitiveness in scenarios with drastic increases in commodity prices during the time period modeled. Another use of the existing outputs of the Monte-Carlo analysis was then realized by showing them on a multivariate scatter plot. This plot was then shown to enable by appropriate grouping of variables to enable the top down definition of an aircraft design, also known as inverse design. In other words this enables the designer to define strategic market and return on investment goals for a number of scenarios, for example the development of fuel prices, and then directly see which specific aircraft designs meet these goals.

Global Design Optimization for Aerodynamics and Rocket Propulsion Components

NASA Technical Reports Server (NTRS)

Shyy, Wei; Papila, Nilay; Vaidyanathan, Rajkumar; Tucker, Kevin; Turner, James E. (Technical Monitor)

2000-01-01

Modern computational and experimental tools for aerodynamics and propulsion applications have matured to a stage where they can provide substantial insight into engineering processes involving fluid flows, and can be fruitfully utilized to help improve the design of practical devices. In particular, rapid and continuous development in aerospace engineering demands that new design concepts be regularly proposed to meet goals for increased performance, robustness and safety while concurrently decreasing cost. To date, the majority of the effort in design optimization of fluid dynamics has relied on gradient-based search algorithms. Global optimization methods can utilize the information collected from various sources and by different tools. These methods offer multi-criterion optimization, handle the existence of multiple design points and trade-offs via insight into the entire design space, can easily perform tasks in parallel, and are often effective in filtering the noise intrinsic to numerical and experimental data. However, a successful application of the global optimization method needs to address issues related to data requirements with an increase in the number of design variables, and methods for predicting the model performance. In this article, we review recent progress made in establishing suitable global optimization techniques employing neural network and polynomial-based response surface methodologies. Issues addressed include techniques for construction of the response surface, design of experiment techniques for supplying information in an economical manner, optimization procedures and multi-level techniques, and assessment of relative performance between polynomials and neural networks. Examples drawn from wing aerodynamics, turbulent diffuser flows, gas-gas injectors, and supersonic turbines are employed to help demonstrate the issues involved in an engineering design context. Both the usefulness of the existing knowledge to aid current design practices and the need for future research are identified.

Identifying optimum performance trade-offs using a cognitively bounded rational analysis model of discretionary task interleaving.

PubMed

Janssen, Christian P; Brumby, Duncan P; Dowell, John; Chater, Nick; Howes, Andrew

2011-01-01

We report the results of a dual-task study in which participants performed a tracking and typing task under various experimental conditions. An objective payoff function was used to provide explicit feedback on how participants should trade off performance between the tasks. Results show that participants' dual-task interleaving strategy was sensitive to changes in the difficulty of the tracking task and resulted in differences in overall task performance. To test the hypothesis that people select strategies that maximize payoff, a Cognitively Bounded Rational Analysis model was developed. This analysis evaluated a variety of dual-task interleaving strategies to identify the optimal strategy for maximizing payoff in each condition. The model predicts that the region of optimum performance is different between experimental conditions. The correspondence between human data and the prediction of the optimal strategy is found to be remarkably high across a number of performance measures. This suggests that participants were honing their behavior to maximize payoff. Limitations are discussed. Copyright © 2011 Cognitive Science Society, Inc.

Specific prognostic factors for secondary pancreatic infection in severe acute pancreatitis.

PubMed

Armengol-Carrasco, M; Oller, B; Escudero, L E; Roca, J; Gener, J; Rodríguez, N; del Moral, P; Moreno, P

1999-01-01

The aim of the present study was to investigate whether there are specific prognostic factors to predict the development of secondary pancreatic infection (SPI) in severe acute pancreatitis in order to perform a computed tomography-fine needle aspiration with bacteriological sampling at the right moment and confirm the diagnosis. Twenty-five clinical and laboratory parameters were determined sequentially in 150 patients with severe acute pancreatitis (SAP) and univariate, and multivariate regression analyses were done looking for correlation with the development of SPI. Only APACHE II score and C-reactive protein levels were related to the development of SPI in the multivariate analysis. A regression equation was designed using these two parameters, and empiric cut-off points defined the subgroup of patients at high risk of developing secondary pancreatic infection. The results showed that it is possible to predict SPI during SAP allowing bacteriological confirmation and early treatment of this severe condition.

Power Take-off System for Marine Renewable Devices, CRADA Number CRD-14-566

DOE Office of Scientific and Technical Information (OSTI.GOV)

Muljadi, Eduard

Ocean Renewable Power Company (ORPC) proposes a project to develop and test innovative second-generation power take-off (PTO) components for the U.S. Department of Energy's 2013 FOA: Marine and Hydrokinetic System Performance Advancement, Topic Area 2 (Project). Innovative PTO components will include new and improved designs for bearings, couplings and a subsea electrical generator. Specific project objectives include the following: (1) Develop components for an advanced PTO suitable for MHK devices; (2) Bench test these components; (3) Assess the component and system performance benefits; (4) Perform a system integration study to integrate these components into an ORPC hydrokinetic turbine. National Renewablemore » Energy Laboratory (NREL) will participate on the ORPC lead team to review design of the generator and will provide guidance on the design. Based on inputs from the project team, NREL will also provide an economic analysis of the impacts of the proposed system performance advancements.« less

Scaling theory for information networks.

PubMed

Moses, Melanie E; Forrest, Stephanie; Davis, Alan L; Lodder, Mike A; Brown, James H

2008-12-06

Networks distribute energy, materials and information to the components of a variety of natural and human-engineered systems, including organisms, brains, the Internet and microprocessors. Distribution networks enable the integrated and coordinated functioning of these systems, and they also constrain their design. The similar hierarchical branching networks observed in organisms and microprocessors are striking, given that the structure of organisms has evolved via natural selection, while microprocessors are designed by engineers. Metabolic scaling theory (MST) shows that the rate at which networks deliver energy to an organism is proportional to its mass raised to the 3/4 power. We show that computational systems are also characterized by nonlinear network scaling and use MST principles to characterize how information networks scale, focusing on how MST predicts properties of clock distribution networks in microprocessors. The MST equations are modified to account for variation in the size and density of transistors and terminal wires in microprocessors. Based on the scaling of the clock distribution network, we predict a set of trade-offs and performance properties that scale with chip size and the number of transistors. However, there are systematic deviations between power requirements on microprocessors and predictions derived directly from MST. These deviations are addressed by augmenting the model to account for decentralized flow in some microprocessor networks (e.g. in logic networks). More generally, we hypothesize a set of constraints between the size, power and performance of networked information systems including transistors on chips, hosts on the Internet and neurons in the brain.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Naulleau, Patrick; Mochi, Iacopo; Goldberg, Kenneth A.

Defect free masks remain one of the most significant challenges facing the commercialization of extreme ultraviolet (EUV) lithography. Progress on this front requires high-performance wavelength-specific metrology of EUV masks, including high-resolution and aerial-image microscopy performed near the 13.5 nm wavelength. Arguably the most cost-effective and rapid path to proliferating this capability is through the development of Fresnel zoneplate-based microscopes. Given the relative obscurity of such systems, however, modeling tools are not necessarily optimized to deal with them and their imaging properties are poorly understood. Here we present a modeling methodology to analyze zoneplate microscopes based on commercially available optical modelingmore » software and use the technique to investigate the imaging performance of an off-axis EUV microscope design. The modeling predicts that superior performance can be achieved by tilting the zoneplate, making it perpendicular to the chief ray at the center of the field, while designing the zoneplate to explicitly work in that tilted plane. Although the examples presented here are in the realm of EUV mask inspection, the methods described and analysis results are broadly applicable to zoneplate microscopes in general, including full-field soft-x-ray microscopes rou tinely used in the synchrotron community.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Naulleau, Patrick P.; Mochi, Iacopo; Goldberg, Kenneth A.

Defect free masks remain one of the most significant challenges facing the commercialization of extreme ultraviolet (EUV) lithography. Progress on this front requires high-performance wavelength-specific metrology of EUV masks, including high-resolution and aerial-image microscopy performed near the 13.5 nm wavelength. Arguably the most cost-effective and rapid path to proliferating this capability is through the development of Fresnel zoneplate-based microscopes. Given the relative obscurity of such systems, however, modeling tools are not necessarily optimized to deal with them and their imaging properties are poorly understood. Here we present a modeling methodology to analyze zoneplate microscopes based on commercially available optical modelingmore » software and use the technique to investigate the imaging performance of an off-axis EUV microscope design. The modeling predicts that superior performance can be achieved by tilting the zoneplate, making it perpendicular to the chief ray at the center of the field, while designing the zoneplate to explicitly work in that tilted plane. Although the examples presented here are in the realm of EUV mask inspection, the methods described and analysis results are broadly applicable to zoneplate microscopes in general, including full-field soft-x-ray microscopes routinely used in the synchrotron community.« less

Investigations of Fluid-Structure-Coupling and Turbulence Model Effects on the DLR Results of the Fifth AIAA CFD Drag Prediction Workshop

NASA Technical Reports Server (NTRS)

Keye, Stefan; Togiti, Vamish; Eisfeld, Bernhard; Brodersen, Olaf P.; Rivers, Melissa B.

2013-01-01

The accurate calculation of aerodynamic forces and moments is of significant importance during the design phase of an aircraft. Reynolds-averaged Navier-Stokes (RANS) based Computational Fluid Dynamics (CFD) has been strongly developed over the last two decades regarding robustness, efficiency, and capabilities for aerodynamically complex configurations. Incremental aerodynamic coefficients of different designs can be calculated with an acceptable reliability at the cruise design point of transonic aircraft for non-separated flows. But regarding absolute values as well as increments at off-design significant challenges still exist to compute aerodynamic data and the underlying flow physics with the accuracy required. In addition to drag, pitching moments are difficult to predict because small deviations of the pressure distributions, e.g. due to neglecting wing bending and twisting caused by the aerodynamic loads can result in large discrepancies compared to experimental data. Flow separations that start to develop at off-design conditions, e.g. in corner-flows, at trailing edges, or shock induced, can have a strong impact on the predictions of aerodynamic coefficients too. Based on these challenges faced by the CFD community a working group of the AIAA Applied Aerodynamics Technical Committee initiated in 2001 the CFD Drag Prediction Workshop (DPW) series resulting in five international workshops. The results of the participants and the committee are summarized in more than 120 papers. The latest, fifth workshop took place in June 2012 in conjunction with the 30th AIAA Applied Aerodynamics Conference. The results in this paper will evaluate the influence of static aeroelastic wing deformations onto pressure distributions and overall aerodynamic coefficients based on the NASA finite element structural model and the common grids.

A Goal Oriented Approach for Modeling and Analyzing Security Trade-Offs

NASA Astrophysics Data System (ADS)

Elahi, Golnaz; Yu, Eric

In designing software systems, security is typically only one design objective among many. It may compete with other objectives such as functionality, usability, and performance. Too often, security mechanisms such as firewalls, access control, or encryption are adopted without explicit recognition of competing design objectives and their origins in stakeholder interests. Recently, there is increasing acknowledgement that security is ultimately about trade-offs. One can only aim for "good enough" security, given the competing demands from many parties. In this paper, we examine how conceptual modeling can provide explicit and systematic support for analyzing security trade-offs. After considering the desirable criteria for conceptual modeling methods, we examine several existing approaches for dealing with security trade-offs. From analyzing the limitations of existing methods, we propose an extension to the i* framework for security trade-off analysis, taking advantage of its multi-agent and goal orientation. The method was applied to several case studies used to exemplify existing approaches.

Optimized design and control of an off grid solar PV/hydrogen fuel cell power system for green buildings

NASA Astrophysics Data System (ADS)

Ghenai, C.; Bettayeb, M.

2017-11-01

Modelling, simulation, optimization and control strategies are used in this study to design a stand-alone solar PV/Fuel Cell/Battery/Generator hybrid power system to serve the electrical load of a commercial building. The main objective is to design an off grid energy system to meet the desired electric load of the commercial building with high renewable fraction, low emissions and low cost of energy. The goal is to manage the energy consumption of the building, reduce the associate cost and to switch from grid-tied fossil fuel power system to an off grid renewable and cleaner power system. Energy audit was performed in this study to determine the energy consumption of the building. Hourly simulations, modelling and optimization were performed to determine the performance and cost of the hybrid power configurations using different control strategies. The results show that the hybrid off grid solar PV/Fuel Cell/Generator/Battery/Inverter power system offers the best performance for the tested system architectures. From the total energy generated from the off grid hybrid power system, 73% is produced from the solar PV, 24% from the fuel cell and 3% from the backup Diesel generator. The produced power is used to meet all the AC load of the building without power shortage (<0.1%). The hybrid power system produces 18.2% excess power that can be used to serve the thermal load of the building. The proposed hybrid power system is sustainable, economically viable and environmentally friendly: High renewable fraction (66.1%), low levelized cost of energy (92 /MWh), and low carbon dioxide emissions (24 kg CO2/MWh) are achieved.

Generating circularly polarized radiation in the extreme ultraviolet spectral range at the free-electron laser FLASH

NASA Astrophysics Data System (ADS)

von Korff Schmising, Clemens; Weder, David; Noll, Tino; Pfau, Bastian; Hennecke, Martin; Strüber, Christian; Radu, Ilie; Schneider, Michael; Staeck, Steffen; Günther, Christian M.; Lüning, Jan; Merhe, Alaa el dine; Buck, Jens; Hartmann, Gregor; Viefhaus, Jens; Treusch, Rolf; Eisebitt, Stefan

2017-05-01

A new device for polarization control at the free electron laser facility FLASH1 at DESY has been commissioned for user operation. The polarizer is based on phase retardation upon reflection off metallic mirrors. Its performance is characterized in three independent measurements and confirms the theoretical predictions of efficient and broadband generation of circularly polarized radiation in the extreme ultraviolet spectral range from 35 eV to 90 eV. The degree of circular polarization reaches up to 90% while maintaining high total transmission values exceeding 30%. The simple design of the device allows straightforward alignment for user operation and rapid switching between left and right circularly polarized radiation.

Space station prototype Sabatier reactor design verification testing

NASA Technical Reports Server (NTRS)

Cusick, R. J.

1974-01-01

A six-man, flight prototype carbon dioxide reduction subsystem for the SSP ETC/LSS (Space Station Prototype Environmental/Thermal Control and Life Support System) was developed and fabricated for the NASA-Johnson Space Center between February 1971 and October 1973. Component design verification testing was conducted on the Sabatier reactor covering design and off-design conditions as part of this development program. The reactor was designed to convert a minimum of 98 per cent hydrogen to water and methane for both six-man and two-man reactant flow conditions. Important design features of the reactor and test conditions are described. Reactor test results are presented that show design goals were achieved and off-design performance was stable.

Airplane takeoff and landing performance monitoring system

NASA Technical Reports Server (NTRS)

Middleton, David B. (Inventor); Srivatsan, Raghavachari (Inventor); Person, Lee H. (Inventor)

1989-01-01

The invention is a real-time takeoff and landing performance monitoring system which provides the pilot with graphic and metric information to assist in decisions related to achieving rotation speed (V sub R) within the safe zone of the runway or stopping the aircraft on the runway after landing or take off abort. The system processes information in two segments: a pretakeoff segment and a real-time segment. One-time inputs of ambient conditions and airplane configuration information are used in the pretakeoff segment to generate scheduled performance data. The real-time segment uses the scheduled performance data, runway length data and transducer measured parameters to monitor the performance of the airplane throughout the takeoff roll. An important feature of this segment is that it updates the estimated runway rolling friction coefficient. Airplane performance predictions also reflect changes in headwind occurring as the takeoff roll progresses. The system displays the position of the airplane on the runway, indicating runway used and runway available, summarizes the critical information into a situation advisory flag, flags engine failures and off-nominal acceleration performance, and indicates where on the runway particular events such as decision speed (V sub 1), rotation speed (V sub R) and expected stop points will occur based on actual or predicted performance. The display also indicates airspeed, wind vector, engine pressure ratios, second segment climb speed, and balanced field length (BFL). The system detects performance deficiencies by comparing the airplane's present performance with a predicted nominal performance based upon the given conditions.

Validity of the Test of Infant Motor Performance for prediction of 6-, 9- and 12-month scores on the Alberta Infant Motor Scale.

PubMed

Campbell, Suzann K; Kolobe, Thubi H A; Wright, Benjamin D; Linacre, John Michael

2002-04-01

The Test of Infant Motor Performance (TIMP) is a test of functional movement in infants from 32 weeks' post-conceptional age to 4 months postterm. The purpose of this study was to assess in 96 infants (44 females, 52 males) with varying risk, the relation between measures on the TIMP at 7, 30, 60, and 90 days after term age and percentile ranks (PR) on the Alberta Infant Motor Scale (AIMS). Correlation between scores on the TIMP and the AIMS was highest for TIMP tests at 90 days and AIMS testing at 6 months (r=0.67, p=0.0001), but all comparisons were statistically significant except those between the TIMP at 7 days and AIMS PR at 9 months. In a multiple regression analysis combining a perinatal risk score and 7-day TIMP measures to predict 12-month AIMS PR, risk, but not TIMP, predicted outcome (21% of variance explained). At older ages TIMP measures made increasing contributions to prediction of 12-month AIMS PR (30% of variance explained by 90-day TIMP). The best TIMP score to maximize specificity and correctly identify 84% of the infants above versus below the 10th PR at 6 months was a cut-off point of 1 SD below the mean. The same cut-off point correctly identified 88% of the infants at 12 months. A cut-off of -0.5 SD, however, maximized sensitivity at 92%. A negative test result, i.e. score above -0.5 SD at 3 months, carried only a 2% probability of a poor 12-month outcome. We conclude that TIMP scores significantly predict AIMS PR 6 to 12 months later, but the TIMP at 3 months of age has the greatest degree of validity for predicting motor performance on the AIMS at 12 months and can be used clinically to identify infants likely to benefit from intervention.

Design, Fabrication, Optical Testing, and Performance of Diamond Machined Aspheric Mirrors for Ground-Based Near-IR Astronomy

NASA Technical Reports Server (NTRS)

Ohl, Raymond G.; Mink, Ronald; Chambers, V. John; Connelly, Joseph A.; Mentzell, J. Eric; Tveekrem, June L.; Howard, Joseph M.; Preuss, Werner; Schroeder, Mechthild; Sohn, Alex;

Dynamic Systems Analysis for Turbine Based Aero Propulsion Systems

NASA Technical Reports Server (NTRS)

Csank, Jeffrey T.

2016-01-01

The aircraft engine design process seeks to optimize the overall system-level performance, weight, and cost for a given concept. Steady-state simulations and data are used to identify trade-offs that should be balanced to optimize the system in a process known as systems analysis. These systems analysis simulations and data may not adequately capture the true performance trade-offs that exist during transient operation. Dynamic systems analysis provides the capability for assessing the dynamic tradeoffs at an earlier stage of the engine design process. The dynamic systems analysis concept, developed tools, and potential benefit are presented in this paper. To provide this capability, the Tool for Turbine Engine Closed-loop Transient Analysis (TTECTrA) was developed to provide the user with an estimate of the closed-loop performance (response time) and operability (high pressure compressor surge margin) for a given engine design and set of control design requirements. TTECTrA along with engine deterioration information, can be used to develop a more generic relationship between performance and operability that can impact the engine design constraints and potentially lead to a more efficient engine.

Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning

PubMed Central

Bacik, John-Paul; Wrenbeck, Emily E.; Michalczyk, Ryszard; Whitehead, Timothy A.

2017-01-01

Proteins are marginally stable, and an understanding of the sequence determinants for improved protein solubility is highly desired. For enzymes, it is well known that many mutations that increase protein solubility decrease catalytic activity. These competing effects frustrate efforts to design and engineer stable, active enzymes without laborious high-throughput activity screens. To address the trade-off between enzyme solubility and activity, we performed deep mutational scanning using two different screens/selections that purport to gauge protein solubility for two full-length enzymes. We assayed a TEM-1 beta-lactamase variant and levoglucosan kinase (LGK) using yeast surface display (YSD) screening and a twin-arginine translocation pathway selection. We then compared these scans with published experimental fitness landscapes. Results from the YSD screen could explain 37% of the variance in the fitness landscapes for one enzyme. Five percent to 10% of all single missense mutations improve solubility, matching theoretical predictions of global protein stability. For a given solubility-enhancing mutation, the probability that it would retain wild-type fitness was correlated with evolutionary conservation and distance to active site, and anticorrelated with contact number. Hybrid classification models were developed that could predict solubility-enhancing mutations that maintain wild-type fitness with an accuracy of 90%. The downside of using such classification models is the removal of rare mutations that improve both fitness and solubility. To reveal the biophysical basis of enhanced protein solubility and function, we determined the crystallographic structure of one such LGK mutant. Beyond fundamental insights into trade-offs between stability and activity, these results have potential biotechnological applications. PMID:28196882

Towards energy-efficient photonic interconnects

NASA Astrophysics Data System (ADS)

Demir, Yigit; Hardavellas, Nikos

2015-03-01

Silicon photonics have emerged as a promising solution to meet the growing demand for high-bandwidth, low-latency, and energy-efficient on-chip and off-chip communication in many-core processors. However, current silicon-photonic interconnect designs for many-core processors waste a significant amount of power because (a) lasers are always on, even during periods of interconnect inactivity, and (b) microring resonators employ heaters which consume a significant amount of power just to overcome thermal variations and maintain communication on the photonic links, especially in a 3D-stacked design. The problem of high laser power consumption is particularly important as lasers typically have very low energy efficiency, and photonic interconnects often remain underutilized both in scientific computing (compute-intensive execution phases underutilize the interconnect), and in server computing (servers in Google-scale datacenters have a typical utilization of less than 30%). We address the high laser power consumption by proposing EcoLaser+, which is a laser control scheme that saves energy by predicting the interconnect activity and opportunistically turning the on-chip laser off when possible, and also by scaling the width of the communication link based on a runtime prediction of the expected message length. Our laser control scheme can save up to 62 - 92% of the laser energy, and improve the energy efficiency of a manycore processor with negligible performance penalty. We address the high trimming (heating) power consumption of the microrings by proposing insulation methods that reduce the impact of localized heating induced by highly-active components on the 3D-stacked logic die.

Optical multiple access techniques for on-board routing

NASA Technical Reports Server (NTRS)

Mendez, Antonio J.; Park, Eugene; Gagliardi, Robert M.

1992-01-01

The purpose of this research contract was to design and analyze an optical multiple access system, based on Code Division Multiple Access (CDMA) techniques, for on board routing applications on a future communication satellite. The optical multiple access system was to effect the functions of a circuit switch under the control of an autonomous network controller and to serve eight (8) concurrent users at a point to point (port to port) data rate of 180 Mb/s. (At the start of this program, the bit error rate requirement (BER) was undefined, so it was treated as a design variable during the contract effort.) CDMA was selected over other multiple access techniques because it lends itself to bursty, asynchronous, concurrent communication and potentially can be implemented with off the shelf, reliable optical transceivers compatible with long term unattended operations. Temporal, temporal/spatial hybrids and single pulse per row (SPR, sometimes termed 'sonar matrices') matrix types of CDMA designs were considered. The design, analysis, and trade offs required by the statement of work selected a temporal/spatial CDMA scheme which has SPR properties as the preferred solution. This selected design can be implemented for feasibility demonstration with off the shelf components (which are identified in the bill of materials of the contract Final Report). The photonic network architecture of the selected design is based on M(8,4,4) matrix codes. The network requires eight multimode laser transmitters with laser pulses of 0.93 ns operating at 180 Mb/s and 9-13 dBm peak power, and 8 PIN diode receivers with sensitivity of -27 dBm for the 0.93 ns pulses. The wavelength is not critical, but 830 nm technology readily meets the requirements. The passive optical components of the photonic network are all multimode and off the shelf. Bit error rate (BER) computations, based on both electronic noise and intercode crosstalk, predict a raw BER of (10 exp -3) when all eight users are communicating concurrently. If better BER performance is required, then error correction codes (ECC) using near term electronic technology can be used. For example, the M(8,4,4) optical code together with Reed-Solomon (54,38,8) encoding provides a BER of better than (10 exp -11). The optical transceiver must then operate at 256 Mb/s with pulses of 0.65 ns because the 'bits' are now channel symbols.

A finite element-based machine learning approach for modeling the mechanical behavior of the breast tissues under compression in real-time.

PubMed

Martínez-Martínez, F; Rupérez-Moreno, M J; Martínez-Sober, M; Solves-Llorens, J A; Lorente, D; Serrano-López, A J; Martínez-Sanchis, S; Monserrat, C; Martín-Guerrero, J D

2017-11-01

This work presents a data-driven method to simulate, in real-time, the biomechanical behavior of the breast tissues in some image-guided interventions such as biopsies or radiotherapy dose delivery as well as to speed up multimodal registration algorithms. Ten real breasts were used for this work. Their deformation due to the displacement of two compression plates was simulated off-line using the finite element (FE) method. Three machine learning models were trained with the data from those simulations. Then, they were used to predict in real-time the deformation of the breast tissues during the compression. The models were a decision tree and two tree-based ensemble methods (extremely randomized trees and random forest). Two different experimental setups were designed to validate and study the performance of these models under different conditions. The mean 3D Euclidean distance between nodes predicted by the models and those extracted from the FE simulations was calculated to assess the performance of the models in the validation set. The experiments proved that extremely randomized trees performed better than the other two models. The mean error committed by the three models in the prediction of the nodal displacements was under 2 mm, a threshold usually set for clinical applications. The time needed for breast compression prediction is sufficiently short to allow its use in real-time (<0.2 s). Copyright © 2017 Elsevier Ltd. All rights reserved.

Factors predicting work outcome in Japanese patients with schizophrenia: role of multiple functioning levels.

PubMed

Sumiyoshi, Chika; Harvey, Philip D; Takaki, Manabu; Okahisa, Yuko; Sato, Taku; Sora, Ichiro; Nuechterlein, Keith H; Subotnik, Kenneth L; Sumiyoshi, Tomiki

2015-09-01

Functional outcomes in individuals with schizophrenia suggest recovery of cognitive, everyday, and social functioning. Specifically improvement of work status is considered to be most important for their independent living and self-efficacy. The main purposes of the present study were 1) to identify which outcome factors predict occupational functioning, quantified as work hours, and 2) to provide cut-offs on the scales for those factors to attain better work status. Forty-five Japanese patients with schizophrenia and 111 healthy controls entered the study. Cognition, capacity for everyday activities, and social functioning were assessed by the Japanese versions of the MATRICS Cognitive Consensus Battery (MCCB), the UCSD Performance-based Skills Assessment-Brief (UPSA-B), and the Social Functioning Scale Individuals' version modified for the MATRICS-PASS (Modified SFS for PASS), respectively. Potential factors for work outcome were estimated by multiple linear regression analyses (predicting work hours directly) and a multiple logistic regression analyses (predicting dichotomized work status based on work hours). ROC curve analyses were performed to determine cut-off points for differentiating between the better- and poor work status. The results showed that a cognitive component, comprising visual/verbal learning and emotional management, and a social functioning component, comprising independent living and vocational functioning, were potential factors for predicting work hours/status. Cut-off points obtained in ROC analyses indicated that 60-70% achievements on the measures of those factors were expected to maintain the better work status. Our findings suggest that improvement on specific aspects of cognitive and social functioning are important for work outcome in patients with schizophrenia.

Pratt and Whitney Overview and Advanced Health Management Program

NASA Technical Reports Server (NTRS)

Inabinett, Calvin

2008-01-01

Hardware Development Activity: Design and Test Custom Multi-layer Circuit Boards for use in the Fault Emulation Unit; Logic design performed using VHDL; Layout power system for lab hardware; Work lab issues with software developers and software testers; Interface with Engine Systems personnel with performance of Engine hardware components; Perform off nominal testing with new engine hardware.

Evaluation of the Predictive Index for Osteoporosis as a Clinical Tool to Identify the Risk of Osteoporosis in Korean Men by Using the Korea National Health and Nutrition Examination Survey Data.

PubMed

Moon, Ji Hyun; Kim, Lee Oh; Kim, Hyeon Ju; Kong, Mi Hee

2016-11-01

We previously proposed the Predictive Index for Osteoporosis as a new index to identify men who require bone mineral density measurement. However, the previous study had limitations such as a single-center design and small sample size. Here, we evaluated the usefulness of the Predictive Index for Osteoporosis using the nationally representative data of the Korea National Health and Nutrition Examination Survey. Participants underwent bone mineral density measurements via dual energy X-ray absorptiometry, and the Predictive Index for Osteoporosis and Osteoporosis Self-Assessment Tool for Asians were assessed. Receiver operating characteristic analysis was used to obtain optimal cut-off points for the Predictive Index for Osteoporosis and Osteoporosis Self-Assessment Tool for Asians, and the predictability of osteoporosis for the 2 indices was compared. Both indices were useful clinical tools for identifying osteoporosis risk in Korean men. The optimal cut-off value for the Predictive Index for Osteoporosis was 1.07 (sensitivity, 67.6%; specificity, 72.7%; area under the curve, 0.743). When using a cut-off point of 0.5 for the Osteoporosis Self-Assessment Tool for Asians, the sensitivity and specificity were 71.9% and 64.0%, respectively, and the area under the curve was 0.737. The Predictive Index for Osteoporosis was as useful as the Osteoporosis Self-Assessment Tool for Asians as a screening index to identify candidates for dual energy X-ray absorptiometry among men aged 50-69 years.

Lactate clearance as the predictor of outcome in pediatric septic shock.

PubMed

Choudhary, Richa; Sitaraman, Sadasivan; Choudhary, Anita

2017-01-01

Septic shock can rapidly evolve into multiple system organ failure and death. In the recent years, hyperlactatemia has been found to be a risk factor for mortality in critically ill adults. To evaluate the predictive value of lactate clearance and to determine the optimal cut-off value for predicting outcome in children with septic shock. A prospective observational study was performed on children with septic shock admitted to pediatric Intensive Care Unit (PICU). Serial lactate levels were measured at PICU admission, 24 and 48 h later. Lactate clearance, percent decrease in lactate level in 24 h, was calculated. The primary outcome measure was survival or nonsurvival at the end of hospital stay. We performed receiver operating characteristic analyses to calculate optimal cut-off values. The mean lactate levels at admission were significantly higher in the nonsurvivors than survivors, 5.12 ± 3.51 versus 3.13 ± 1.71 mmol/L ( P = 0.0001). The cut-off for lactate level at admission for the best prediction of mortality was determined as ≥4 mmol/L (odds ratio 5.4; 95% confidence interval [CI] =2.45-12.09). Mean lactate clearance was significantly higher in survivors than nonsurvivors (17.9 ± 39.9 vs. -23.2 ± 62.7; P < 0.0001). A lactate clearance rate of <10% at 24 h had a sensitivity and specificity of 78.7% and 72.2%, respectively and a positive predictive value of 83.1% for death. Failure to achieve a lactate clearance of more than 10% was associated with greater risk of mortality (likelihood ratio + 2.83; 95% CI = 1.82-4.41). Serial lactate levels can be used to predict outcome in pediatric septic shock. A 24 h lactate clearance cut-off of <10% is a predictor of in-hospital mortality in such patients.

Analysis, testing, and operation of the MAGI thermal control system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yi, Sonny; Hall, Jeffrey L.; Kasper, Brian P.

2014-01-29

The Aerospace Corporation has completed the development of the Mineral and Gas Identifier (MAGI) sensor - an airborne multi-spectral infrared instrument that is designed to discriminate surface composition and to detect gas emissions from the environment. Sensor performance was demonstrated in a series of flights aboard a Twin Otter aircraft in December 2011 as a stepping stone to a future satellite sensor design. To meet sensor performance requirements the thermal control system was designed to operate the HgCdTe focal plane array (FPA) at 50 K with a 1.79 W heat rejection load to a 44.7 K sink and the opticalmore » assembly at 100 K with a 7.5 W heat load to a 82.3 K sink. Two commercial off-theshelf (COTS) Sunpower Stirling cryocoolers were used to meet the instrument’s cooling requirements. A thermal model constructed in Thermal Desktop was used to run parametric studies that guided the mechanical design and sized the two cryocoolers. This paper discusses the development, validation, and operation of the MAGI thermal control system. Detailed energy balances and temperature predictions are presented for various test cases to demonstrate the utility and accuracy of the thermal model. Model inputs included measured values of heat lift as a function of input power and cold tip temperature for the two cryocoolers. These measurements were also used to make predictions of the cool-down behavior from ambient conditions. Advanced heater software was developed to meet unique requirements for both sensor cool-down rate and stability at the set point temperatures.« less

Systems design and analysis of the microwave radiometer spacecraft

NASA Technical Reports Server (NTRS)

Garrett, L. B.

1981-01-01

Systems design and analysis data were generated for microwave radiometer spacecraft concept using the Large Advanced Space Systems (LASS) computer aided design and analysis program. Parametric analyses were conducted for perturbations off the nominal-orbital-altitude/antenna-reflector-size and for control/propulsion system options. Optimized spacecraft mass, structural element design, and on-orbit loading data are presented. Propulsion and rigid-body control systems sensitivities to current and advanced technology are established. Spacecraft-induced and environmental effects on antenna performance (surface accuracy, defocus, and boresight off-set) are quantified and structured material frequencies and modal shapes are defined.

The cut-off values of anthropometric variables for predicting mild cognitive impairment in Malaysian older adults: a large population based cross-sectional study

PubMed Central

Won, Huiloo; Abdul, Manaf Zahara; Mat Ludin, Arimi Fitri; Omar, Mohd Azahadi; Razali, Rosdinom; Shahar, Suzana

2017-01-01

Purpose Older adults are at risk of mild cognitive impairment (MCI), and simple anthropometric measurements can be used to screen for this condition. Thus, the aim of this study was to explore the cut-off values of body mass index (BMI) and waist circumference (WC) for predicting the risk of MCI in older Malaysian adults. Methods A total of 2,240 Malaysian older adults aged ≥60 years were recruited using multistage random sampling in a population based cross-sectional study. Receiver operating characteristic (ROC) curve was used to determine the cut-off values of BMI and WC with optimum sensitivity and specificity for the detection of MCI. Age, gender, years of education, smoking habit, alcohol consumption, depression, and medical conditions were used as confounding factors in this analysis. Results A BMI cut-off value of 26 kg/m2 (area under the receiver operating characteristic curve [AUC] 0.725; sensitivity 90.5%; specificity 38.8%) was appropriate in identifying the risk of getting MCI in both men and women. The optimum WC cut-offs for likelihood of MCI were 90 cm (AUC 0.745; sensitivity 78.0%; specificity 59.8%) for men and 82 cm (AUC 0.714; sensitivity 84.3%; specificity 49.7%) for women. The optimum calf circumference (CC) cut-off values for identifying MCI were 29 cm (AUC 0.731; sensitivity 72.6%; specificity 61.1%) for men and 26 cm (AUC 0.598; sensitivity 79.1%; specificity 45.3%) for women. Conclusion The cut-off values could be advocated and used as part of the screening of MCI among older Malaysian adults. There is a need to further determine the predictive values of these cut-off points on outcomes through longitudinal study design. PMID:28223785

NHLBI-AbDesigner: an online tool for design of peptide-directed antibodies.

PubMed

Pisitkun, Trairak; Hoffert, Jason D; Saeed, Fahad; Knepper, Mark A

2012-01-01

Investigation of physiological mechanisms at a cellular level often requires production of high-quality antibodies, frequently using synthetic peptides as immunogens. Here we describe a new, web-based software tool called NHLBI-AbDesigner that allows the user to visualize the information needed to choose optimal peptide sequences for peptide-directed antibody production (http://helixweb.nih.gov/AbDesigner/). The choice of an immunizing peptide is generally based on a need to optimize immunogenicity, antibody specificity, multispecies conservation, and robustness in the face of posttranslational modifications (PTMs). AbDesigner displays information relevant to these criteria as follows: 1) "Immunogenicity Score," based on hydropathy and secondary structure prediction; 2) "Uniqueness Score," a predictor of specificity of an antibody against all proteins expressed in the same species; 3) "Conservation Score," a predictor of ability of the antibody to recognize orthologs in other animal species; and 4) "Protein Features" that show structural domains, variable regions, and annotated PTMs that may affect antibody performance. AbDesigner displays the information online in an interactive graphical user interface, which allows the user to recognize the trade-offs that exist for alternative synthetic peptide choices and to choose the one that is best for a proposed application. Several examples of the use of AbDesigner for the display of such trade-offs are presented, including production of a new antibody to Slc9a3. We also used the program in large-scale mode to create a database listing the 15-amino acid peptides with the highest Immunogenicity Scores for all known proteins in five animal species, one plant species (Arabidopsis thaliana), and Saccharomyces cerevisiae.

Design trade-offs for homing missiles

NASA Astrophysics Data System (ADS)

Spencer, Allen; Moore, William

1992-05-01

Major design considerations, trade-offs and technology issues for future hypervelocity, anti-missile interceptors are presented in an overview format. Two classes of interceptors are considered: a low altitude interceptor using an active radar seeker for defense against tactical ballistic missiles (TBMs) and a higher altitude interceptor using a passive infra-red seeker for defense against ICBMs. Considerations are presented in the areas of mission requirements, seeker selection, aerodynamic and aerothermal environments, control systems, and guidance performance.

Comparison of anthropometric indices (body mass index, waist circumference, waist to hip ratio and waist to height ratio) in predicting risk of type II diabetes in the population of Yazd, Iran.

PubMed

Mirzaei, Masoud; Khajeh, Mohammad

2018-04-13

The purpose of this study was to determine the best anthropometric index and calculate the cut-off point for each anthropometric index in predicting the risk of type II diabetes in the population of Yazd city in Iran. The present analytical cross-sectional study was performed using the data from Yazd Health Study (YaHS) with a sample size of 9293. All required data including anthropometric indices BMI, WC, WHR, and WHtR were extracted from the YAHS questionnaire. The ROC curve was employed to compare the predictive power of each anthropometric index in the risk of developing the type II diabetes. WHtR in both genders had better predictive power for the risk of type II diabetes (AUC = 0.692 for males and AUC = 0.708 for females), and BMI showed a weaker predictive power (AUC = 0.603 for males and AUC = 0.632 for females), WC and WHR also revealed similar predictive power in the risk of type II diabetes. The cut-off point of BMI for predicting the risk of diabetes was almost identical in both genders (26.2 in males and 25.9 in females), the cut-off point of WC (91 cm), and WHtR (0.56) in males was lower than in the females (96 cm for WC and 0.605 for WHtR). The cut-off point of WHR in males (0.939) was higher than in females (0.892). The WHtR showed the best predictor of diabetes risk compared to other indices, and the BMI was the weakest predictor of the risk for diabetes. Copyright © 2018. Published by Elsevier Ltd.

The Impact of Current and Future Polar Orbiting Satellite Data on Numerical Weather Prediction at NASA/GSFC

NASA Technical Reports Server (NTRS)

Atlas, Robert

2004-01-01

The lack of adequate observational data continues to be recognized as a major factor limiting both atmospheric research and numerical prediction on a variety of temporal and spatial scales. Since the advent of meteorological satellites in the 1960's, a considerable research effort has been directed toward the design of space-borne meteorological sensors, the development of optimal methods for the utilization of these data, (and an assessment of the influence of existing satellite data and the potential influence of future satellite observations on numerical weather prediction. This has included both Observing System Experiments (OSEs) and Observing System Simulation Experiments (OSSEs). OSEs are conducted to evaluate the impact of specific observations or classes of observations on analyses and forecasts. While OSEs are performed with existing data, OSSEs are conducted to evaluate the potential for future observing systems to improve-NWP, as well as to evaluate trade-offs in observing system design, and to develop and test improved methods for data assimilation. At the conference, results from OSEs to evaluate satellite data sets that have recently become available to the global observing system, such as AIRS and Seawinds, and results from OSSEs to determine the potential impact of space-based lidar winds will be presented.

Design and Implementation of a Motor Incremental Shaft Encoder

DTIC Science & Technology

2008-09-01

SDC Student Design Center VHDL Verilog Hardware Description Language VSC Voltage Source Converters ZCE Zero Crossing Event xiii EXECUTIVE...student to make accurate predictions of voltage source converters ( VSC ) behavior via software simulation; these simulated results could also be... VSC ), and several other off-the-shelf components, a circuit board interface between FPGA and the power source, and a desktop computer [1]. Now, the

Optimal allocation of thermodynamic irreversibility for the integrated design of propulsion and thermal management systems

NASA Astrophysics Data System (ADS)

Maser, Adam Charles

More electric aircraft systems, high power avionics, and a reduction in heat sink capacity have placed a larger emphasis on correctly satisfying aircraft thermal management requirements during conceptual design. Thermal management systems must be capable of dealing with these rising heat loads, while simultaneously meeting mission performance. Since all subsystem power and cooling requirements are ultimately traced back to the engine, the growing interactions between the propulsion and thermal management systems are becoming more significant. As a result, it is necessary to consider their integrated performance during the conceptual design of the aircraft gas turbine engine cycle to ensure that thermal requirements are met. This can be accomplished by using thermodynamic subsystem modeling and simulation while conducting the necessary design trades to establish the engine cycle. However, this approach also poses technical challenges associated with the existence of elaborate aircraft subsystem interactions. This research addresses these challenges through the creation of a parsimonious, transparent thermodynamic model of propulsion and thermal management systems performance with a focus on capturing the physics that have the largest impact on propulsion design choices. This modeling environment, known as Cycle Refinement for Aircraft Thermodynamically Optimized Subsystems (CRATOS), is capable of operating in on-design (parametric) and off-design (performance) modes and includes a system-level solver to enforce design constraints. A key aspect of this approach is the incorporation of physics-based formulations involving the concurrent usage of the first and second laws of thermodynamics, which are necessary to achieve a clearer view of the component-level losses across the propulsion and thermal management systems. This is facilitated by the direct prediction of the exergy destruction distribution throughout the system and the resulting quantification of available work losses over the time history of the mission. The characterization of the thermodynamic irreversibility distribution helps give the propulsion systems designer an absolute and consistent view of the tradeoffs associated with the design of the entire integrated system. Consequently, this leads directly to the question of the proper allocation of irreversibility across each of the components. The process of searching for the most favorable allocation of this irreversibility is the central theme of the research and must take into account production cost and vehicle mission performance. The production cost element is accomplished by including an engine component weight and cost prediction capability within the system model. The vehicle mission performance is obtained by directly linking the propulsion and thermal management model to a vehicle performance model and flying it through a mission profile. A canonical propulsion and thermal management systems architecture is then presented to experimentally test each element of the methodology separately: first the integrated modeling and simulation, then the irreversibility, cost, and mission performance considerations, and then finally the proper technique to perform the optimal allocation. A goal of this research is the description of the optimal allocation of system irreversibility to enable an engine cycle design with improved performance and cost at the vehicle-level. To do this, a numerical optimization was first used to minimize system-level production and operating costs by fixing the performance requirements and identifying the best settings for all of the design variables. There are two major drawbacks to this approach: It does not allow the designer to directly trade off the performance requirements and it does not allow the individual component losses to directly factor into the optimization. An irreversibility allocation approach based on the economic concept of resource allocation is then compared to the numerical optimization. By posing the problem in economic terms, exergy destruction is treated as a true common currency to barter for improved efficiency, cost, and performance. This allows the designer to clearly see how changes in the irreversibility distribution impact the overall system. The inverse design is first performed through a filtered Monte Carlo to allow the designer to view the irreversibility design space. The designer can then directly perform the allocation using the exergy destruction, which helps to place the design choices on an even thermodynamic footing. Finally, two use cases are presented to show how the irreversibility allocation approach can assist the designer. The first describes a situation where the designer can better address competing system-level requirements; the second describes a different situation where the designer can choose from a number of options to improve a system in a manner that is more robust to future requirements.

A Biophysical Model of CRISPR/Cas9 Activity for Rational Design of Genome Editing and Gene Regulation

PubMed Central

Farasat, Iman; Salis, Howard M.

2016-01-01

The ability to precisely modify genomes and regulate specific genes will greatly accelerate several medical and engineering applications. The CRISPR/Cas9 (Type II) system binds and cuts DNA using guide RNAs, though the variables that control its on-target and off-target activity remain poorly characterized. Here, we develop and parameterize a system-wide biophysical model of Cas9-based genome editing and gene regulation to predict how changing guide RNA sequences, DNA superhelical densities, Cas9 and crRNA expression levels, organisms and growth conditions, and experimental conditions collectively control the dynamics of dCas9-based binding and Cas9-based cleavage at all DNA sites with both canonical and non-canonical PAMs. We combine statistical thermodynamics and kinetics to model Cas9:crRNA complex formation, diffusion, site selection, reversible R-loop formation, and cleavage, using large amounts of structural, biochemical, expression, and next-generation sequencing data to determine kinetic parameters and develop free energy models. Our results identify DNA supercoiling as a novel mechanism controlling Cas9 binding. Using the model, we predict Cas9 off-target binding frequencies across the lambdaphage and human genomes, and explain why Cas9’s off-target activity can be so high. With this improved understanding, we propose several rules for designing experiments for minimizing off-target activity. We also discuss the implications for engineering dCas9-based genetic circuits. PMID:26824432

Doppler lidar power, aperture diameter, and FFT size trade-off study

NASA Astrophysics Data System (ADS)

Chester, David B.; Budge, Scott E.

2017-05-01

In the design or selection of a Doppler lidar instrument for a spacecraft landing system, it is important to evaluate the balance between performance requirements and cost, weight, and power consumption. Leveraging the capability of LadarSIM, a trade-off study was performed to evaluate the interaction between the laser transmission power, aperture diameter, and FFT size in a Doppler lidar system. For this study the probabilities of detection and false alarm were calculated using LadarSIM to simulate FMCW lidar systems with varying power, aperture diameter, and FFT size. This paper reports the results of this trade-off study.

Does resident ranking during recruitment accurately predict subsequent performance as a surgical resident?

PubMed

Fryer, Jonathan P; Corcoran, Noreen; George, Brian; Wang, Ed; Darosa, Debra

2012-01-01

While the primary goal of ranking applicants for surgical residency training positions is to identify the candidates who will subsequently perform best as surgical residents, the effectiveness of the ranking process has not been adequately studied. We evaluated our general surgery resident recruitment process between 2001 and 2011 inclusive, to determine if our recruitment ranking parameters effectively predicted subsequent resident performance. We identified 3 candidate ranking parameters (United States Medical Licensing Examination [USMLE] Step 1 score, unadjusted ranking score [URS], and final adjusted ranking [FAR]), and 4 resident performance parameters (American Board of Surgery In-Training Examination [ABSITE] score, PGY1 resident evaluation grade [REG], overall REG, and independent faculty rating ranking [IFRR]), and assessed whether the former were predictive of the latter. Analyses utilized Spearman correlation coefficient. We found that the URS, which is based on objective and criterion based parameters, was a better predictor of subsequent performance than the FAR, which is a modification of the URS based on subsequent determinations of the resident selection committee. USMLE score was a reliable predictor of ABSITE scores only. However, when we compared our worst residence performances with the performances of the other residents in this evaluation, the data did not produce convincing evidence that poor resident performances could be reliably predicted by any of the recruitment ranking parameters. Finally, stratifying candidates based on their rank range did not effectively define a ranking cut-off beyond which resident performance would drop off. Based on these findings, we recommend surgery programs may be better served by utilizing a more structured resident ranking process and that subsequent adjustments to the rank list generated by this process should be undertaken with caution. Copyright © 2012 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

Of Uberfleas and Krakens: Detecting Trade-offs Using Mixed Models.

PubMed

Careau, Vincent; Wilson, Robbie S

2017-08-01

All animals experience performance trade-offs as they complete tasks such as capturing prey, defending territories, acquiring mates, and escaping predators. Why then, is it so hard to detect performance trade-offs at the whole-organismal level? Why do we sometimes even obtain positive correlations between two performance traits that are predicted to be negatively associated? Here we explore two plausible explanations. First, most analyses are based on individual maximal values (i.e., personal best), which could introduce a bias in the correlation estimates. Second, phenotypic correlations alone may be poor indicators of a trade-off when contrasting processes occur at the among- versus within-individual levels. One such scenario is the "big houses big cars" model developed in life-history theory to explain the existence of "uberfleas" that are superior in all regards (because they acquire more resources than others). We highlight that the exact opposite scenario might occur for performance trade-offs, where among-individual trade-offs may be masked by within-individual changes in physical condition. One of the best ways to test among these alternative scenarios is to collect repeated pairs of performance traits and analyze them using multivariate mixed models (MMMs). MMMs allow straightforward and simultaneous examination of trait correlations at the among- and within-individual levels. We use a simple simulation tool (SQuID package in R) to create a population of Krakens, a mythical giant squid-like sea creature whose morphology generates a performance trade-off between swimming speed and strength or ability to sink ships. The simulations showed that using individual maximum values introduces a bias that is particularly severe when individuals differ in the number of repeated samples (ntrial). Finally, we show how MMMs can help detect performance (or any other type of) trade-offs and offer additional insights (e.g., help detect plasticity integration). We hope researchers will adopt MMMs when exploring trade-offs in whole-animal performances. © The Author 2017. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

Screening reservoir systems by considering the efficient trade-offs—informing infrastructure investment decisions on the Blue Nile

NASA Astrophysics Data System (ADS)

Geressu, Robel T.; Harou, Julien J.

2015-12-01

Multi-reservoir system planners should consider how new dams impact downstream reservoirs and the potential contribution of each component to coordinated management. We propose an optimized multi-criteria screening approach to identify best performing designs, i.e., the selection, size and operating rules of new reservoirs within multi-reservoir systems. Reservoir release operating rules and storage sizes are optimized concurrently for each separate infrastructure design under consideration. Outputs reveal system trade-offs using multi-dimensional scatter plots where each point represents an approximately Pareto-optimal design. The method is applied to proposed Blue Nile River reservoirs in Ethiopia, where trade-offs between total and firm energy output, aggregate storage and downstream irrigation and energy provision for the best performing designs are evaluated. This proof-of concept study shows that recommended Blue Nile system designs would depend on whether monthly firm energy or annual energy is prioritized. 39 TWh/yr of energy potential is available from the proposed Blue Nile reservoirs. The results show that depending on the amount of energy deemed sufficient, the current maximum capacities of the planned reservoirs could be larger than they need to be. The method can also be used to inform which of the proposed reservoir type and their storage sizes would allow for the highest downstream benefits to Sudan in different objectives of upstream operating objectives (i.e., operated to maximize either average annual energy or firm energy). The proposed approach identifies the most promising system designs, reveals how they imply different trade-offs between metrics of system performance, and helps system planners asses the sensitivity of overall performance to the design parameters of component reservoirs.

An Experimental and Computational Investigation of Oscillating Airfoil Unsteady Aerodynamics at Large Mean Incidence

NASA Technical Reports Server (NTRS)

Capece, Vincent R.; Platzer, Max F.

2003-01-01

A major challenge in the design and development of turbomachine airfoils for gas turbine engines is high cycle fatigue failures due to flutter and aerodynamically induced forced vibrations. In order to predict the aeroelastic response of gas turbine airfoils early in the design phase, accurate unsteady aerodynamic models are required. However, accurate predictions of flutter and forced vibration stress at all operating conditions have remained elusive. The overall objectives of this research program are to develop a transition model suitable for unsteady separated flow and quantify the effects of transition on airfoil steady and unsteady aerodynamics for attached and separated flow using this model. Furthermore, the capability of current state-of-the-art unsteady aerodynamic models to predict the oscillating airfoil response of compressor airfoils over a range of realistic reduced frequencies, Mach numbers, and loading levels will be evaluated through correlation with benchmark data. This comprehensive evaluation will assess the assumptions used in unsteady aerodynamic models. The results of this evaluation can be used to direct improvement of current models and the development of future models. The transition modeling effort will also make strides in improving predictions of steady flow performance of fan and compressor blades at off-design conditions. This report summarizes the progress and results obtained in the first year of this program. These include: installation and verification of the operation of the parallel version of TURBO; the grid generation and initiation of steady flow simulations of the NASA/Pratt&Whitney airfoil at a Mach number of 0.5 and chordal incidence angles of 0 and 10 deg.; and the investigation of the prediction of laminar separation bubbles on a NACA 0012 airfoil.

Predicting ground contact events for a continuum of gait types: An application of targeted machine learning using principal component analysis.

PubMed

Osis, Sean T; Hettinga, Blayne A; Ferber, Reed

2016-05-01

An ongoing challenge in the application of gait analysis to clinical settings is the standardized detection of temporal events, with unobtrusive and cost-effective equipment, for a wide range of gait types. The purpose of the current study was to investigate a targeted machine learning approach for the prediction of timing for foot strike (or initial contact) and toe-off, using only kinematics for walking, forefoot running, and heel-toe running. Data were categorized by gait type and split into a training set (∼30%) and a validation set (∼70%). A principal component analysis was performed, and separate linear models were trained and validated for foot strike and toe-off, using ground reaction force data as a gold-standard for event timing. Results indicate the model predicted both foot strike and toe-off timing to within 20ms of the gold-standard for more than 95% of cases in walking and running gaits. The machine learning approach continues to provide robust timing predictions for clinical use, and may offer a flexible methodology to handle new events and gait types. Copyright © 2016 Elsevier B.V. All rights reserved.

An evaluation of composite propulsion for single-stage-to-orbit vehicles designed for horizontal take-off

NASA Technical Reports Server (NTRS)

Martin, J. A.

1977-01-01

Composite propulsion was analyzed for single-stage-to-orbit vehicles designed for horizontal take-off. Trajectory, geometric, and mass analyses were performed to establish the orbital payload capability of six engines. The results indicated that none of the engines performed adequately to deliver payloads to orbit as analyzed. The single-stage turbine and oxidizer-rich gas generator resulted in a low engine specific impulse, and the performance increment of the ejector subsystem was less than that of a separate rocket system with a high combustion pressure. There was a benefit from incorporating a fan into the engine, and removal of the fan from the airstream during the ramjet mode increased the orbital payload capability.

Second-generation mobile satellite system. A conceptual design and trade-off study

NASA Technical Reports Server (NTRS)

Sue, M. K.; Park, Y. H.

1985-01-01

In recent years, interest has grown in the mobile satellite (MSAT) system, a satellite-based communications system capable of providing integrated voice and data services to a large number of users. To explore the potential of a commercial mobile satellite system (MSS) beyond the horizon of the first generation, using technologies of the 1990's and to assist MSAT-X in directing its efforts, a conceptual design has been performed for a second-generation system to be launched around the mid-1990's. The design goal is to maximize the number of satellite channels and/or minimize the overall life-cycle cost, subject to the constraint of utilizing a commercial satellite bus with minimum modifications. To provide an optimal design, a series of trade-offs are performed, including antenna sizing, feed configurations, and interference analysis. Interference is a serious problem for MSAT and often an overlapping feed design is required to reduce interbeam interference. The trade-off studies will show that a simple non-overlapping feed is sufficient for the second-generation system, thus avoiding the need for the complicated beam-forming network that is associated with the overlapping feed designs. In addition, a system that operates at L-band, an alternative frequency band that is being considered by some for possible MSAT applications, is also presented.

Performance of Optimized Prosthetic Ankle Designs That Are Based on a Hydraulic Variable Displacement Actuator (VDA).

PubMed

Gardiner, James; Bari, Abu Zeeshan; Kenney, Laurence; Twiste, Martin; Moser, David; Zahedi, Saeed; Howard, David

2017-12-01

Current energy storage and return prosthetic feet only marginally reduce the cost of amputee locomotion compared with basic solid ankle cushioned heel feet, possibly due to their lack of push-off at the end of stance. To the best of our knowledge, a prosthetic ankle that utilizes a hydraulic variable displacement actuator (VDA) to improve push-off performance has not previously been proposed. Therefore, here we report a design optimization and simulation feasibility study for a VDA-based prosthetic ankle. The proposed device stores the eccentric ankle work done from heel strike to maximum dorsiflexion in a hydraulic accumulator and then returns the stored energy to power push-off. Optimization was used to establish the best spring characteristic and gear ratio between ankle and VDA. The corresponding simulations show that, in level walking, normal push-off is achieved and, per gait cycle, the energy stored in the accumulator increases by 22% of the requirements for normal push-off. Although the results are promising, there are many unanswered questions and, for this approach to be a success, a new miniature, low-losses, and lightweight VDA would be required that is half the size of the smallest commercially available device.

An Analysis of the Autorotative Performance of a Helicopter Powered by Rotor-Tip Jet Units

NASA Technical Reports Server (NTRS)

Gessow, Alfred

1950-01-01

The autorotative performance of an assumed helicopter was studied to determine the effect of inoperative jet units located at the rotor-blade tip on the helicopter rate of descent. For a representative ramjet design, the effect of the jet drag is to increase the minimum rate of descent of the helicopter from about 1,OO feet per minute to 3,700 feet per minute when the rotor is operating at a tip speed of approximately 600 feet per second. The effect is less if the rotor operates at lower tip speeds, but the rotor kinetic energy and the stall margin available for the landing maneuver are then reduced. Power-off rates of descent of pulse-jet helicopters would be expected to be less than those of ramjet. helicopters because pulse jets of current design appear to have greater ratios of net power-on thrust to power-off, drag than currently designed rain jets. Iii order to obtain greater accuracy in studies of autorotative performance, calculations in'volving high power-off rates of descent should include the weight-supporting effect of the fuselage parasite-drag force and the fact that the rotor thrust does not equal the weight of the helicopter.

Sustained attention failures are primarily due to sustained cognitive load not task monotony.

PubMed

Head, James; Helton, William S

2014-11-01

We conducted two studies using a modified sustained attention to response task (SART) to investigate the developmental process of SART performance and the role of cognitive load on performance when the speed-accuracy trade-off is controlled experimentally. In study 1, 23 participants completed the modified SART (target stimuli location was not predictable) and a subjective thought content questionnaire 4 times over the span of 4 weeks. As predicted, the influence of speed-accuracy trade-off was significantly mitigated on the modified SART by having target stimuli occur in unpredictable locations. In study 2, 21 of the 23 participants completed an abridged version of the modified SART with a verbal free-recall memory task. Participants performed significantly worse when completing the verbal memory task and SART concurrently. Overall, the results support a resource theory perspective with concern to errors being a result of limited mental resources and not simply mindlessness per se. Copyright © 2014. Published by Elsevier B.V.

SU-D-213-05: Design, Evaluation and First Applications of a Off-Site State-Of-The-Art 3D Dosimetry System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malcolm, J; Mein, S; McNiven, A

2015-06-15

Purpose: To design, construct and commission a prototype in-house three dimensional (3D) dose verification system for stereotatic body radiotherapy (SBRT) verification at an off-site partner institution. To investigate the potential of this system to achieve sufficient performance (1mm resolution, 3% noise, within 3% of true dose reading) for SBRT verification. Methods: The system was designed utilizing a parallel ray geometry instigated by precision telecentric lenses and an LED 630nm light source. Using a radiochromic dosimeter, a 3D dosimetric comparison with our gold-standard system and treatment planning software (Eclipse) was done for a four-field box treatment, under gamma passing criteria ofmore » 3%/3mm/10% dose threshold. Post off-site installation, deviations in the system’s dose readout performance was assessed by rescanning the four-field box irradiated dosimeter and using line-profiles to compare on-site and off-site mean and noise levels in four distinct dose regions. As a final step, an end-to-end test of the system was completed at the off-site location, including CT-simulation, irradiation of the dosimeter and a 3D dosimetric comparison of the planned (Pinnacle{sup 3}) to delivered dose for a spinal SBRT treatment(12 Gy per fraction). Results: The noise level in the high and medium dose regions of the four field box treatment was relatively 5% pre and post installation. This reflects the reduction in positional uncertainty through the new design. This At 1mm dose voxels, the gamma pass rates(3%,3mm) for our in-house gold standard system and the off-site system were comparable at 95.8% and 93.2% respectively. Conclusion: This work will describe the end-to-end process and results of designing, installing, and commissioning a state-of-the-art 3D dosimetry system created for verification of advanced radiation treatments including spinal radiosurgery.« less

Development of a Cross-Flow Fan Rotor for Vertical Take-Off and Landing Aircraft

DTIC Science & Technology

2013-06-01

ANSYS CFX , along with the commercial computer-aided design software SolidWorks, was used to model and perform a parametric study on the number of rotor...the results found using ANSYS CFX . The experimental and analytical models were successfully compared at speeds ranging from 4,000 to 7,000 RPM...will make vertical take-off possible. The commercial computational fluid dynamics software ANSYS CFX , along with the commercial computer-aided design

Performance of a Turboprop Engine with Heat Recovery in Off-Design Conditions

NASA Astrophysics Data System (ADS)

Andriani, Roberto; Ghezzi, Umberto; Gamma, Fausto; Ingenito, Antonella; Agresta, Antonio

2013-09-01

The research for fuel consumption and pollution reduction in new generation aero engines has indicated intercooling and regeneration as very effective methods for this purpose. Hence, different countries have joined their efforts in common research programs, to develop new gas turbine engines able to reduce considerably the fuel consumption and the ambient impact by means of these two techniques. To study their effects on the engine performance and characteristics, a thermodynamic numerical program that simulates the behavior of a turboprop engine with intercooling and regeneration in different operating conditions has been developed. After the parametric study, and the definition of the design conditions, the off-design analysis is carried on, comparing the main characteristics of the intercooled-regenerated turboprop with those of a conventional engine. Then, once a particular mission profile was fixed, the engine performance, in particular the equivalent power, the fuel consumption and the heat exchanger weight were discussed.

Transonic Investigation of Two-Dimensional Nozzles Designed for Supersonic Cruise

NASA Technical Reports Server (NTRS)

Capone, Francis J.; Deere, Karen A.

2015-01-01

An experimental and computational investigation has been conducted to determine the off-design uninstalled drag characteristics of a two-dimensional convergent-divergent nozzle designed for a supersonic cruise civil transport. The overall objectives were to: (1) determine the effects of nozzle external flap curvature and sidewall boattail variations on boattail drag; (2) develop an experimental data base for 2D nozzles with long divergent flaps and small boattail angles and (3) provide data for correlating computational fluid dynamic predictions of nozzle boattail drag. The experimental investigation was conducted in the Langley 16-Foot Transonic Tunnel at Mach numbers from 0.80 to 1.20 at nozzle pressure ratios up to 9. Three-dimensional simulations of nozzle performance were obtained with the computational fluid dynamics code PAB3D using turbulence closure and nonlinear Reynolds stress modeling. The results of this investigation indicate that excellent correlation between experimental and predicted results was obtained for the nozzle with a moderate amount of boattail curvature. The nozzle with an external flap having a sharp shoulder (no curvature) had the lowest nozzle pressure drag. At a Mach number of 1.2, sidewall pressure drag doubled as sidewall boattail angle was increased from 4deg to 8deg. Reducing the height of the sidewall caused large decreases in both the sidewall and flap pressure drags. Summary

Computer-aided drug design at Boehringer Ingelheim

NASA Astrophysics Data System (ADS)

Muegge, Ingo; Bergner, Andreas; Kriegl, Jan M.

2017-03-01

Computer-Aided Drug Design (CADD) is an integral part of the drug discovery endeavor at Boehringer Ingelheim (BI). CADD contributes to the evaluation of new therapeutic concepts, identifies small molecule starting points for drug discovery, and develops strategies for optimizing hit and lead compounds. The CADD scientists at BI benefit from the global use and development of both software platforms and computational services. A number of computational techniques developed in-house have significantly changed the way early drug discovery is carried out at BI. In particular, virtual screening in vast chemical spaces, which can be accessed by combinatorial chemistry, has added a new option for the identification of hits in many projects. Recently, a new framework has been implemented allowing fast, interactive predictions of relevant on and off target endpoints and other optimization parameters. In addition to the introduction of this new framework at BI, CADD has been focusing on the enablement of medicinal chemists to independently perform an increasing amount of molecular modeling and design work. This is made possible through the deployment of MOE as a global modeling platform, allowing computational and medicinal chemists to freely share ideas and modeling results. Furthermore, a central communication layer called the computational chemistry framework provides broad access to predictive models and other computational services.

Using a shock control bump to improve the performance of an axial compressor blade section

NASA Astrophysics Data System (ADS)

Mazaheri, K.; Khatibirad, S.

2017-03-01

Here, we use numerical analysis to study the effects of a shock control bump (SCB) on the performance of a transonic axial compressor blade section and to optimize its shape and location to improve the compressor performance. A section of the NASA rotor 67 blade is used for this study. Two Bézier curves, each consisting of seven control points, are used to model the suction and pressure surfaces of the blade section. The SCB is modeled with the Hicks-Henne function and, using five design parameters, is added to the suction side. The total pressure loss through a cascade of blade sections is selected as the cost function. A continuous adjoint optimization method is used along with a RANS solver to find a new blade section shape. A grid independence study is performed, and all optimization and flow solver algorithms are validated. Two single-point optimizations are performed in the design condition and in an off-design condition. It is shown that both optimized shapes have overall better performance for both on-design and off-design conditions. An analysis is given regarding how the SCB has changed the wave structure between blade sections resulting in a more favorable flow pattern.

[Formulation of combined predictive indicators using logistic regression model in predicting sepsis and prognosis].

PubMed

Duan, Liwei; Zhang, Sheng; Lin, Zhaofen

2017-02-01

To explore the method and performance of using multiple indices to diagnose sepsis and to predict the prognosis of severe ill patients. Critically ill patients at first admission to intensive care unit (ICU) of Changzheng Hospital, Second Military Medical University, from January 2014 to September 2015 were enrolled if the following conditions were satisfied: (1) patients were 18-75 years old; (2) the length of ICU stay was more than 24 hours; (3) All records of the patients were available. Data of the patients was collected by searching the electronic medical record system. Logistic regression model was formulated to create the new combined predictive indicator and the receiver operating characteristic (ROC) curve for the new predictive indicator was built. The area under the ROC curve (AUC) for both the new indicator and original ones were compared. The optimal cut-off point was obtained where the Youden index reached the maximum value. Diagnostic parameters such as sensitivity, specificity and predictive accuracy were also calculated for comparison. Finally, individual values were substituted into the equation to test the performance in predicting clinical outcomes. A total of 362 patients (218 males and 144 females) were enrolled in our study and 66 patients died. The average age was (48.3±19.3) years old. (1) For the predictive model only containing categorical covariants [including procalcitonin (PCT), lipopolysaccharide (LPS), infection, white blood cells count (WBC) and fever], increased PCT, increased WBC and fever were demonstrated to be independent risk factors for sepsis in the logistic equation. The AUC for the new combined predictive indicator was higher than that of any other indictor, including PCT, LPS, infection, WBC and fever (0.930 vs. 0.661, 0.503, 0.570, 0.837, 0.800). The optimal cut-off value for the new combined predictive indicator was 0.518. Using the new indicator to diagnose sepsis, the sensitivity, specificity and diagnostic accuracy rate were 78.00%, 93.36% and 87.47%, respectively. One patient was randomly selected, and the clinical data was substituted into the probability equation for prediction. The calculated value was 0.015, which was less than the cut-off value (0.518), indicating that the prognosis was non-sepsis at an accuracy of 87.47%. (2) For the predictive model only containing continuous covariants, the logistic model which combined acute physiology and chronic health evaluation II (APACHE II) score and sequential organ failure assessment (SOFA) score to predict in-hospital death events, both APACHE II score and SOFA score were independent risk factors for death. The AUC for the new predictive indicator was higher than that of APACHE II score and SOFA score (0.834 vs. 0.812, 0.813). The optimal cut-off value for the new combined predictive indicator in predicting in-hospital death events was 0.236, and the corresponding sensitivity, specificity and diagnostic accuracy for the combined predictive indicator were 73.12%, 76.51% and 75.70%, respectively. One patient was randomly selected, and the APACHE II score and SOFA score was substituted into the probability equation for prediction. The calculated value was 0.570, which was higher than the cut-off value (0.236), indicating that the death prognosis at an accuracy of 75.70%. The combined predictive indicator, which is formulated by logistic regression models, is superior to any single indicator in predicting sepsis or in-hospital death events.

Proposal for a New Predictive Model of Short-Term Mortality After Living Donor Liver Transplantation due to Acute Liver Failure.

PubMed

Chung, Hyun Sik; Lee, Yu Jung; Jo, Yun Sung

2017-02-21

BACKGROUND Acute liver failure (ALF) is known to be a rapidly progressive and fatal disease. Various models which could help to estimate the post-transplant outcome for ALF have been developed; however, none of them have been proved to be the definitive predictive model of accuracy. We suggest a new predictive model, and investigated which model has the highest predictive accuracy for the short-term outcome in patients who underwent living donor liver transplantation (LDLT) due to ALF. MATERIAL AND METHODS Data from a total 88 patients were collected retrospectively. King's College Hospital criteria (KCH), Child-Turcotte-Pugh (CTP) classification, and model for end-stage liver disease (MELD) score were calculated. Univariate analysis was performed, and then multivariate statistical adjustment for preoperative variables of ALF prognosis was performed. A new predictive model was developed, called the MELD conjugated serum phosphorus model (MELD-p). The individual diagnostic accuracy and cut-off value of models in predicting 3-month post-transplant mortality were evaluated using the area under the receiver operating characteristic curve (AUC). The difference in AUC between MELD-p and the other models was analyzed. The diagnostic improvement in MELD-p was assessed using the net reclassification improvement (NRI) and integrated discrimination improvement (IDI). RESULTS The MELD-p and MELD scores had high predictive accuracy (AUC >0.9). KCH and serum phosphorus had an acceptable predictive ability (AUC >0.7). The CTP classification failed to show discriminative accuracy in predicting 3-month post-transplant mortality. The difference in AUC between MELD-p and the other models had statistically significant associations with CTP and KCH. The cut-off value of MELD-p was 3.98 for predicting 3-month post-transplant mortality. The NRI was 9.9% and the IDI was 2.9%. CONCLUSIONS MELD-p score can predict 3-month post-transplant mortality better than other scoring systems after LDLT due to ALF. The recommended cut-off value of MELD-p is 3.98.

Novel pump head design for high energy 1064 nm oscillator amplifier system for lidar applications

NASA Astrophysics Data System (ADS)

Willis, Christina C. C.; Witt, Greg; Martin, Nigel; Albert, Michael; Culpepper, Charles; Burnham, Ralph

2017-02-01

Many scientific endeavors are benefitted by the development of increasingly high energy laser sources for lidar applications. Space-based applications for lidar require compact, efficient and high energy sources, and we have designed a novel gain head that is compatible with these requirements. The gain medium for the novel design consists of a composite Nd:YAG/Sm:YAG slab, wherein the Sm:YAG portion absorbs any parasitic 1064 nm oscillations that might occur in the main pump axis. A pump cavity is built around the slab, consisting of angled gold-coated reflectors which allow for five pump passes from each of the four pumping locations around the slab. Pumping is performed with off-axis diode bars, allowing for highly compact conductively cooled design. Optical and thermal modeling of this design was done to verify and predict its performance. In order to ultimately achieve 50 W average power at a repetition rate of 500 Hz, three heads of this design will be used in a MOPA configuration with two stages of amplification. To demonstrate the pump head we built it into a 1064 nm laser cavity and performed initial amplification experiments. Modeling and design of the system is presented along with the initial oscillator and amplifier results. The greatest pulse energy produced from the seeded q-switched linear oscillator was an output of 25 mJ at 500 Hz. With an input of 25 mJ and two planned stages of amplification, we expect to readily reach 100 mJ or more per pulse.

Optics ellipticity performance of an unobscured off-axis space telescope.

PubMed

Zeng, Fei; Zhang, Xin; Zhang, Jianping; Shi, Guangwei; Wu, Hongbo

2014-10-20

With the development of astronomy, more and more attention is paid to the survey of dark matter. Dark matter cannot be seen directly but can be detected by weak gravitational lensing measurement. Ellipticity is an important parameter used to define the shape of a galaxy. Galaxy ellipticity changes with weak gravitational lensing and nonideal optics. With our design of an unobscured off-axis telescope, we implement the simulation and calculation of optics ellipticity. With an accurate model of optics PSF, the characteristic of ellipticity is modeled and analyzed. It is shown that with good optical design, the full field ellipticity can be quite small. The spatial ellipticity change can be modeled by cubic interpolation with very high accuracy. We also modeled the ellipticity variance with time and analyzed the tolerance. It is shown that the unobscured off-axis telescope has good ellipticity performance and fulfills the requirement of dark matter survey.

NASA contributions to radial turbine aerodynamic analyses

NASA Technical Reports Server (NTRS)

Glassman, A. J.

1980-01-01

A brief description of the radial turbine and its analysis needs is followed by discussions of five analytical areas; design geometry and performance, off design performance, blade row flow, scroll flow, and duct flow. The functions of the programs, areas of applicability, and limitations and uncertainties are emphasized. Both past contributions and current activities are discussed.

Design of two-column batch-to-batch recirculation to enhance performance in ion-exchange chromatography.

PubMed

Persson, Oliver; Andersson, Niklas; Nilsson, Bernt

2018-01-05

Preparative liquid chromatography is a separation technique widely used in the manufacturing of fine chemicals and pharmaceuticals. A major drawback of traditional single-column batch chromatography step is the trade-off between product purity and process performance. Recirculation of impure product can be utilized to make the trade-off more favorable. The aim of the present study was to investigate the usage of a two-column batch-to-batch recirculation process step to increase the performance compared to single-column batch chromatography at a high purity requirement. The separation of a ternary protein mixture on ion-exchange chromatography columns was used to evaluate the proposed process. The investigation used modelling and simulation of the process step, experimental validation and optimization of the simulated process. In the presented case the yield increases from 45.4% to 93.6% and the productivity increases 3.4 times compared to the performance of a batch run for a nominal case. A rapid concentration build-up product can be seen during the first cycles, before the process reaches a cyclic steady-state with reoccurring concentration profiles. The optimization of the simulation model predicts that the recirculated salt can be used as a flying start of the elution, which would enhance the process performance. The proposed process is more complex than a batch process, but may improve the separation performance, especially while operating at cyclic steady-state. The recirculation of impure fractions reduces the product losses and ensures separation of product to a high degree of purity. Copyright © 2017 Elsevier B.V. All rights reserved.

"Off-Spotter": very fast and exhaustive enumeration of genomic lookalikes for designing CRISPR/Cas guide RNAs.

PubMed

Pliatsika, Venetia; Rigoutsos, Isidore

2015-01-29

CRISPR/Cas (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated nucleases) is a powerful component of the prokaryotic immune system that has been adapted for targeted genetic engineering in higher organisms. A key element of CRISPR/Cas is the "guide" RNA (gRNA) that is ~20 nucleotides (nts) in length and designed to be complementary to the intended target site. An integral requirement of the CRISPR/Cas system is that the target site be followed by a protospacer adjacent motif (PAM). Care needs to be exercised during gRNA design to avoid unintended ("off-target") interactions. We designed and implemented the Off-Spotter algorithm to assist with the design of optimal gRNAs. When presented with a candidate gRNA sequence and a PAM, Off-Spotter quickly and exhaustively identifies all genomic sites that satisfy the PAM constraint and are identical or nearly-identical to the provided gRNA. Off-Spotter achieves its extreme performance through purely algorithmic means and not through hardware accelerators such as graphical processing units (GPUs). Off-Spotter also allows the user to identify on-the-fly how many and which nucleotides of the gRNA comprise the "seed". Off-Spotter's output includes a histogram showing the number of potential off-targets as a function of the number of mismatches. The output also includes for each potential off-target the site's genomic location, a human genome browser hyperlink to the corresponding location, genomic annotation in the vicinity of the off-target, GC content, etc. Off-Spotter is very fast and flexible and can help in the design of optimal gRNAs by providing several PAM choices, a run-time definition of the seed and of the allowed number of mismatches, and a flexible output interface that allows sorting of the results, optional viewing/hiding of columns, etc. A key element of Off-Spotter is that it does not have a rigid definition of the seed: instead, the user can declare both the seed's location and extent on-the-fly. We expect that this flexibility in combination with Off-Spotter's speed and richly annotated output will enable experimenters to interactively and quickly explore different scenarios and gRNA possibilities.

Data driven CAN node reliability assessment for manufacturing system

NASA Astrophysics Data System (ADS)

Zhang, Leiming; Yuan, Yong; Lei, Yong

2017-01-01

The reliability of the Controller Area Network(CAN) is critical to the performance and safety of the system. However, direct bus-off time assessment tools are lacking in practice due to inaccessibility of the node information and the complexity of the node interactions upon errors. In order to measure the mean time to bus-off(MTTB) of all the nodes, a novel data driven node bus-off time assessment method for CAN network is proposed by directly using network error information. First, the corresponding network error event sequence for each node is constructed using multiple-layer network error information. Then, the generalized zero inflated Poisson process(GZIP) model is established for each node based on the error event sequence. Finally, the stochastic model is constructed to predict the MTTB of the node. The accelerated case studies with different error injection rates are conducted on a laboratory network to demonstrate the proposed method, where the network errors are generated by a computer controlled error injection system. Experiment results show that the MTTB of nodes predicted by the proposed method agree well with observations in the case studies. The proposed data driven node time to bus-off assessment method for CAN networks can successfully predict the MTTB of nodes by directly using network error event data.

Predicting vertical jump height from bar velocity.

PubMed

García-Ramos, Amador; Štirn, Igor; Padial, Paulino; Argüelles-Cienfuegos, Javier; De la Fuente, Blanca; Strojnik, Vojko; Feriche, Belén

2015-06-01

The objective of the study was to assess the use of maximum (Vmax) and final propulsive phase (FPV) bar velocity to predict jump height in the weighted jump squat. FPV was defined as the velocity reached just before bar acceleration was lower than gravity (-9.81 m·s(-2)). Vertical jump height was calculated from the take-off velocity (Vtake-off) provided by a force platform. Thirty swimmers belonging to the National Slovenian swimming team performed a jump squat incremental loading test, lifting 25%, 50%, 75% and 100% of body weight in a Smith machine. Jump performance was simultaneously monitored using an AMTI portable force platform and a linear velocity transducer attached to the barbell. Simple linear regression was used to estimate jump height from the Vmax and FPV recorded by the linear velocity transducer. Vmax (y = 16.577x - 16.384) was able to explain 93% of jump height variance with a standard error of the estimate of 1.47 cm. FPV (y = 12.828x - 6.504) was able to explain 91% of jump height variance with a standard error of the estimate of 1.66 cm. Despite that both variables resulted to be good predictors, heteroscedasticity in the differences between FPV and Vtake-off was observed (r(2) = 0.307), while the differences between Vmax and Vtake-off were homogenously distributed (r(2) = 0.071). These results suggest that Vmax is a valid tool for estimating vertical jump height in a loaded jump squat test performed in a Smith machine. Key pointsVertical jump height in the loaded jump squat can be estimated with acceptable precision from the maximum bar velocity recorded by a linear velocity transducer.The relationship between the point at which bar acceleration is less than -9.81 m·s(-2) and the real take-off is affected by the velocity of movement.Mean propulsive velocity recorded by a linear velocity transducer does not appear to be optimal to monitor ballistic exercise performance.

Predicting Vertical Jump Height from Bar Velocity

PubMed Central

García-Ramos, Amador; Štirn, Igor; Padial, Paulino; Argüelles-Cienfuegos, Javier; De la Fuente, Blanca; Strojnik, Vojko; Feriche, Belén

2015-01-01

The objective of the study was to assess the use of maximum (Vmax) and final propulsive phase (FPV) bar velocity to predict jump height in the weighted jump squat. FPV was defined as the velocity reached just before bar acceleration was lower than gravity (-9.81 m·s-2). Vertical jump height was calculated from the take-off velocity (Vtake-off) provided by a force platform. Thirty swimmers belonging to the National Slovenian swimming team performed a jump squat incremental loading test, lifting 25%, 50%, 75% and 100% of body weight in a Smith machine. Jump performance was simultaneously monitored using an AMTI portable force platform and a linear velocity transducer attached to the barbell. Simple linear regression was used to estimate jump height from the Vmax and FPV recorded by the linear velocity transducer. Vmax (y = 16.577x - 16.384) was able to explain 93% of jump height variance with a standard error of the estimate of 1.47 cm. FPV (y = 12.828x - 6.504) was able to explain 91% of jump height variance with a standard error of the estimate of 1.66 cm. Despite that both variables resulted to be good predictors, heteroscedasticity in the differences between FPV and Vtake-off was observed (r2 = 0.307), while the differences between Vmax and Vtake-off were homogenously distributed (r2 = 0.071). These results suggest that Vmax is a valid tool for estimating vertical jump height in a loaded jump squat test performed in a Smith machine. Key points Vertical jump height in the loaded jump squat can be estimated with acceptable precision from the maximum bar velocity recorded by a linear velocity transducer. The relationship between the point at which bar acceleration is less than -9.81 m·s-2 and the real take-off is affected by the velocity of movement. Mean propulsive velocity recorded by a linear velocity transducer does not appear to be optimal to monitor ballistic exercise performance. PMID:25983572

PNIC - A near infrared camera for testing focal plane arrays

NASA Astrophysics Data System (ADS)

Hereld, Mark; Harper, D. A.; Pernic, R. J.; Rauscher, Bernard J.

1990-07-01

This paper describes the design and the performance of the Astrophysical Research Consortium prototype near-infrared camera (pNIC) designed to test focal plane arrays both on and off the telescope. Special attention is given to the detector in pNIC, the mechanical and optical designs, the electronics, and the instrument interface. Experiments performed to illustrate the most salient aspects of pNIC are described.

Local feedback control of light honeycomb panels.

PubMed

Hong, Chinsuk; Elliott, Stephen J

2007-01-01

This paper summarizes theoretical and experimental work on the feedback control of sound radiation from honeycomb panels using piezoceramic actuators. It is motivated by the problem of sound transmission in aircraft, specifically the active control of trim panels. Trim panels are generally honeycomb structures designed to meet the design requirement of low weight and high stiffness. They are resiliently mounted to the fuselage for the passive reduction of noise transmission. Local coupling of the closely spaced sensor and actuator was observed experimentally and modeled using a single degree of freedom system. The effect of the local coupling was to roll off the response between the actuator and sensor at high frequencies, so that a feedback control system can have high gain margins. Unfortunately, only relatively poor global performance is then achieved because of localization of reduction around the actuator. This localization prompts the investigation of a multichannel active control system. Globalized reduction was predicted using a model of 12-channel direct velocity feedback control. The multichannel system, however, does not appear to yield a significant improvement in the performance because of decreased gain margin.

Exploring symmetry in near-vacuum hohlraums

NASA Astrophysics Data System (ADS)

Berzak Hopkins, L.; Le Pape, S.; Divol, L.; Meezan, N.; MacKinnon, A.; Ho, D. D.; Jones, O.; Khan, S.; Ma, T.; Milovich, J.; Pak, A.; Ross, J. S.; Thomas, C.; Turnbull, D.; Amendt, P.; Wilks, S.; Zylstra, A.; Rinderknecht, H.; Sio, H.; Petrasso, R.

2015-11-01

Recent experiments with near-vacuum hohlraums, which utilize a minimal but non-zero helium fill, have demonstrated performance improvements relative to conventional gas-filled (0.96 - 1.6 mg/cc helium) hohlraums: minimal backscatter, reduced capsule drive degradation, and minimal suprathermal electron generation. Because this is a low laser-plasma interaction platform, implosion symmetry is controlled via pulse-shaping adjustments to laser power balance. Extending this platform to high-yield designs with high-density carbon capsules requires achieving adequate symmetry control throughout the pulse. In simulations, laser propagation is degraded suddenly by hohlraum wall expansion interacting with ablated capsule material. Nominal radiation-hydrodynamics simulations have not yet proven predictive on symmetry of the final hotspot, and experiments show more prolate symmetry than preshot calculations. Recent efforts have focused on understanding the discrepancy between simulated and measured symmetry and on alternate designs for symmetry control through varying cone fraction, trade-offs between laser power and energy, and modifications to case-to-capsule ratio. Work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under contract DE-AC52-07NA27344.

Observing System Forecast Experiments at the DAO

NASA Technical Reports Server (NTRS)

Atlas, Robert

2001-01-01

Since the advent of meteorological satellites in the 1960's, numerous experiments have been conducted in order to evaluate the impact of these and other data on atmospheric analysis and prediction. Such studies have included both OSE'S and OSSE's. The OSE's were conducted to evaluate the impact of specific observations or classes of observations on analyses and forecasts. Such experiments have been performed for selected types of conventional data and for various satellite data sets as they became available. (See for example the 1989 ECMWF/EUMETSAT workshop proceedings on "The use of satellite data in operational numerical weather prediction" and the references contained therein.) The ODYSSEY were conducted to evaluate the potential for future observing systems to improve Numerical Weather Prediction NWP and to plan for the Global Weather Experiment and more recently for EVANS (Atlas et al., 1985a; Arnold and Day, 1986; Hoffman et al., 1990). In addition, OSSE's have been run to evaluate trade-offs in the design of observing systems and observing networks (Atlas and Emmitt, 1991; Rohaly and Krishnamurti, 1993), and to test new methodology for data assimilation (Atlas and Bloom, 1989).

Effects of elevated temperature on the viscoplastic modeling of graphite/polymeric composites

NASA Technical Reports Server (NTRS)

Gates, Thomas S.

1991-01-01

To support the development of new materials for the design of next generation supersonic transports, a research program is underway at NASA to assess the long term durability of advanced polymer matrix composites (PMC's). One of main objectives of the program was to explore the effects of elevated temperature (23 to 200 C) on the constitutive model's material parameters. To achieve this goal, test data on the observed nonlinear, stress-strain behavior of IM7/5260 and IM7/8320 composites under tension and compression loading were collected and correlated against temperature. These tests, conducted under isothermal conditions using variable strain rates, included such phenomena as stress relaxation and short term creep. The second major goal was the verification of the model by comparison of analytical predictions and test results for off axis and angle ply laminates. Correlation between test and predicted behavior was performed for specimens of both material systems over a range of temperatures. Results indicated that the model provided reasonable predictions of material behavior in load or strain controlled tests. Periods of loading, unloading, stress relaxation, and creep were accounted for.

Axial and Centrifugal Compressor Mean Line Flow Analysis Method

NASA Technical Reports Server (NTRS)

Veres, Joseph P.

2009-01-01

This paper describes a method to estimate key aerodynamic parameters of single and multistage axial and centrifugal compressors. This mean-line compressor code COMDES provides the capability of sizing single and multistage compressors quickly during the conceptual design process. Based on the compressible fluid flow equations and the Euler equation, the code can estimate rotor inlet and exit blade angles when run in the design mode. The design point rotor efficiency and stator losses are inputs to the code, and are modeled at off design. When run in the off-design analysis mode, it can be used to generate performance maps based on simple models for losses due to rotor incidence and inlet guide vane reset angle. The code can provide an improved understanding of basic aerodynamic parameters such as diffusion factor, loading levels and incidence, when matching multistage compressor blade rows at design and at part-speed operation. Rotor loading levels and relative velocity ratio are correlated to the onset of compressor surge. NASA Stage 37 and the three-stage NASA 74-A axial compressors were analyzed and the results compared to test data. The code has been used to generate the performance map for the NASA 76-B three-stage axial compressor featuring variable geometry. The compressor stages were aerodynamically matched at off-design speeds by adjusting the variable inlet guide vane and variable stator geometry angles to control the rotor diffusion factor and incidence angles.

Pentraxin 3 predicts complicated course of febrile neutropenia in haematological patients, but the decision level depends on the underlying malignancy.

PubMed

Juutilainen, Auni; Vänskä, Matti; Pulkki, Kari; Hämäläinen, Sari; Nousiainen, Tapio; Jantunen, Esa; Koivula, Irma

2011-11-01

This study aimed at assessing the cut-off levels for pentraxin 3 (PTX3) in predicting complications of neutropenic fever (bacteraemia, septic shock) in haematological patients. A prospective study during 2006-2009 was performed at haematology ward in Kuopio University Hospital. A patient was eligible for the study if having neutropenic fever after intensive therapy for acute myeloid leukaemia (AML) (n = 32) or non-Hodgkin lymphoma (NHL) (n = 35). Blood cultures were taken, and maximal PTX3 and C-reactive protein (CRP) were evaluated during d0 to d3 from the beginning of fever onset. The level of PTX3 was associated with both the underlying malignancy and the presence of complications, with highest level in NHL patients with complicated course of febrile neutropenia and lowest in AML patients with non-complicated course. The cut-off level of PTX3 to predict complications was ten-fold in patients with NHL (115 μg/L) in comparison with patients with AML (11.5 μg/L). In combined analysis based on separate cut-offs, PTX3 predicted complications of febrile neutropenia with sensitivity of 0.86, specificity of 0.83, positive predictive value of 0.57 and negative predictive value of 0.96.   PTX3 was superior to CRP in predicting complicated course of febrile neutropenia, but only when the effect of the underlying malignancy had been taken into account. © 2011 John Wiley & Sons A/S.

The FLIGHT Drosophila RNAi database

PubMed Central

Bursteinas, Borisas; Jain, Ekta; Gao, Qiong; Baum, Buzz; Zvelebil, Marketa

2010-01-01

FLIGHT (http://flight.icr.ac.uk/) is an online resource compiling data from high-throughput Drosophila in vivo and in vitro RNAi screens. FLIGHT includes details of RNAi reagents and their predicted off-target effects, alongside RNAi screen hits, scores and phenotypes, including images from high-content screens. The latest release of FLIGHT is designed to enable users to upload, analyze, integrate and share their own RNAi screens. Users can perform multiple normalizations, view quality control plots, detect and assign screen hits and compare hits from multiple screens using a variety of methods including hierarchical clustering. FLIGHT integrates RNAi screen data with microarray gene expression as well as genomic annotations and genetic/physical interaction datasets to provide a single interface for RNAi screen analysis and datamining in Drosophila. PMID:20855970

Short optical pulse generation at 40 GHz with a bulk electro-absorption modulator packaged device

NASA Astrophysics Data System (ADS)

Langlois, Patrick; Moore, Ronald; Prosyk, Kelvin; O'Keefe, Sean; Oosterom, Jill A.; Betty, Ian; Foster, Robert; Greenspan, Jonathan; Singh, Priti

2003-12-01

Short optical pulse generation at 40GHz and 1540nm wavelength is achieved using fully packaged bulk quaternary electro-absorption modulator modules. Experimental results obtained with broadband and narrowband optimized packaged modules are presented and compared against empirical model predictions. Pulse duty cycle, extinction ratio and chirp are studied as a function of sinusoidal drive voltage and detuning between operating wavelength and modulator absorption band edge. Design rules and performance trade-offs are discussed. Low-chirp pulses with a FWHM of ~12ps and sub-4ps at a rate of 40GHz are demonstrated. Optical time-domain demultiplexing of a 40GHz to a 10GHz pulse train is also demonstrated with better than 20dB extinction ratio.

Rectangular Relief Diffraction Gratings for Coherent Lidar Beam Scanning

NASA Technical Reports Server (NTRS)

Cole, H. J.; Chambers, D. M.; Dixit, S. N.; Britten, J. A.; Shore, B. W.; Kavaya, M. J.

1999-01-01

The application of specialized rectangular relief transmission gratings to coherent lidar beam scanning is presented. Two types of surface relief transmission grating approaches are studied with an eye toward potential insertion of a constant thickness, diffractive scanner where refractive wedges now exist. The first diffractive approach uses vertically oriented relief structure in the surface of an optical flat; illumination of the diffractive scanner is off-normal in nature. The second grating design case describes rectangular relief structure slanted at a prescribed angle with respect to the surface. In this case, illumination is normal to the diffractive scanner. In both cases, performance predictions for 2.0 micron, circularly polarized light at beam deflection angles of 30 or 45 degrees are presented.

Results of an Advanced Fan Stage Operating Over a Wide Range of Speed and Bypass Ratio. Part 2; Comparison of CFD and Experimental Results

NASA Technical Reports Server (NTRS)

Celestina, Mark L.; Suder, Kenneth L.; Kulkarni, Sameer

2010-01-01

NASA and GE teamed to design and build a 57 percent engine scaled fan stage for a Mach 4 variable cycle turbofan/ramjet engine for access to space with multipoint operations. This fan stage was tested in NASA's transonic compressor facility. The objectives of this test were to assess the aerodynamic and aero mechanic performance and operability characteristics of the fan stage over the entire range of engine operation including: 1) sea level static take-off; 2) transition over large swings in fan bypass ratio; 3) transition from turbofan to ramjet; and 4) fan wind-milling operation at high Mach flight conditions. This paper will focus on an assessment of APNASA, a multistage turbomachinery analysis code developed by NASA, to predict the fan stage performance and operability over a wide range of speeds (37 to 100 percent) and bypass ratios.

Speed and stamina trade-off in lacertid lizards.

PubMed

Vanhooydonck, B; Van Damme, R; Aerts, P

2001-05-01

Morphological and physiological considerations suggest that sprinting ability and endurance capacity put conflicting demands on the design of an animal's locomotor apparatus and therefore cannot be maximized simultaneously. To test this hypothesis, we correlated size-corrected maximal sprint speed and stamina of 12 species of lacertid lizards. Phylogenetically independent contrasts of sprint speed and stamina showed a significant negative relationship, giving support to the idea of an evolutionary trade-off between the two performance measures. To test the hypothesis that the trade-off is mediated by a conflict in morphological requirements, we correlated both performance traits with snout-vent length, size-corrected estimates of body mass and limb length, and relative hindlimb length (the residuals of the relationship between hind- and forelimb length). Fast-running species had hindlimbs that were long compared to their forelimbs. None of the other size or shape variables showed a significant relationship with speed or endurance. We conclude that the evolution of sprint capacity may be constrained by the need for endurance capacity and vice versa, but the design conflict underlying this trade-off has yet to be identified.

Stress distribution of the foot during mid-stance to push-off in barefoot gait: a 3-D finite element analysis.

PubMed

Chen, W P; Tang, F T; Ju, C W

2001-08-01

To quantify stress distribution of the foot during mid-stance to push-off in barefoot gait using 3-D finite element analysis. To simulate the foot structure and facilitate later consideration of footwear. Finite element model was generated and loading condition simulating barefoot gait during mid-stance to push-off was used to quantify the stress distributions. A computational model can provide overall stress distributions of the foot subject to various loading conditions. A preliminary 3-D finite element foot model was generated based on the computed tomography data of a male subject and the bone and soft tissue structures were modeled. Analysis was performed for loading condition simulating barefoot gait during mid-stance to push-off. The peak plantar pressure ranged from 374 to 1003 kPa and the peak von Mises stress in the bone ranged from 2.12 to 6.91 MPa at different instants. The plantar pressure patterns were similar to measurement result from previous literature. The present study provides a preliminary computational model that is capable of estimating the overall plantar pressure and bone stress distributions. It can also provide quantitative analysis for normal and pathological foot motion. This model can identify areas of increased pressure and correlate the pressure with foot pathology. Potential applications can be found in the study of foot deformities, footwear, surgical interventions. It may assist pre-treatment planning, design of pedorthotic appliances, and predict the treatment effect of foot orthosis.

A discussion on mobile satellite system and the myths of CDMA and diversity revealed

NASA Technical Reports Server (NTRS)

Hart, Nicholas; Goerke, Thomas; Jahn, Axel

1995-01-01

The paper explores the myths and facts surrounding: link margins and constellation designs; the use of satellite diversity in a mobile satellite channel; trade-offs in multiple access technique. Different satellite constellations are presented, which are comparable with those used by the big LEO proponents, with the associated trade-offs in the system design. Propagation data and results from various narrowband and wideband measurement campaigns are used to illustrate the expected differences in service performance.

A Method of the UMTS-FDD Network Design Based on Universal Load Characteristics

NASA Astrophysics Data System (ADS)

Gajewski, Slawomir

In the paper an original method of the UMTS radio network design was presented. The method is based on simple way of capacity-coverage trade-off estimation for WCDMA/FDD radio interface. This trade-off is estimated by using universal load characteristics and normalized coverage characteristics. The characteristics are useful for any propagation environment as well as for any service performance requirements. The practical applications of these characteristics on radio network planning and maintenance were described.

Predicted effect of landscape position on wildlife habitat value of Conservation Reserve Enhancement Program wetlands in a tile-drained agricultural region

USGS Publications Warehouse

Otis, David L.; Crumpton, William R.; Green, David; Loan-Wilsey, Anna; Cooper, Tom; Johnson, Rex R.

2013-01-01

Justification for investment in restored or constructed wetland projects are often based on presumed net increases in ecosystem services. However, quantitative assessment of performance metrics is often difficult and restricted to a single objective. More comprehensive performance assessments could help inform decision-makers about trade-offs in services provided by alternative restoration program design attributes. The primary goal of the Iowa Conservation Reserve Enhancement Program is to establish wetlands that efficiently remove nitrates from tile-drained agricultural landscapes. A secondary objective is provision of wildlife habitat. We used existing wildlife habitat models to compare relative net change in potential wildlife habitat value for four alternative landscape positions of wetlands within the watershed. Predicted species richness and habitat value for birds, mammals, amphibians, and reptiles generally increased as the wetland position moved lower in the watershed. However, predicted average net increase between pre- and post-project value was dependent on taxonomic group. The increased average wetland area and changes in surrounding upland habitat composition among landscape positions were responsible for these differences. Net change in predicted densities of several grassland bird species at the four landscape positions was variable and species-dependent. Predicted waterfowl breeding activity was greater for lower drainage position wetlands. Although our models are simplistic and provide only a predictive index of potential habitat value, we believe such assessment exercises can provide a tool for coarse-level comparisons of alternative proposed project attributes and a basis for constructing informed hypotheses in auxiliary empirical field studies.

GENENG 2: A program for calculating design and off-design performance of two- and three-spool turbofans with as many as three nozzles

NASA Technical Reports Server (NTRS)

Fishbach, L. H.; Koenig, R. W.

1972-01-01

A computer program which calculates steady-state design and off-design jet engine performance for two- or three-spool turbofans with one, two, or three nozzles is described. Included in the report are complete FORTRAN 4 listings of the program with sample results for nine basic turbofan engines that can be calculated: (1) three-spool, three-stream engine; (2) two-spool, three-stream, boosted-fan engine; (3) two-spool, three-stream, supercharged-compressor engine; (4) three-spool, two-stream engine; (5) two-spool, two-stream engine; (6) three-spool, three-stream, aft-fan engine; (7) two-spool, three-stream, aft-fan engine; (8) two-spool, two-stream, aft-engine; and (9) three-spool, two-stream, aft-fan engine. The simulation of other engines by using logical variables built into the program is also described.

Real-time on-line space research laboratory environment monitoring with off-line trend and prediction analysis

NASA Astrophysics Data System (ADS)

Jules, Kenol; Lin, Paul P.

2007-06-01

With the International Space Station currently operational, a significant amount of acceleration data is being down-linked, processed and analyzed daily on the ground on a continuous basis for the space station reduced gravity environment characterization, the vehicle design requirements verification and science data collection. To help understand the impact of the unique spacecraft environment on the science data, an artificial intelligence monitoring system was developed, which detects in near real time any change in the reduced gravity environment susceptible to affect the on-going experiments. Using a dynamic graphical display, the monitoring system allows science teams, at any time and any location, to see the active vibration disturbances, such as pumps, fans, compressor, crew exercise, re-boost and extra-vehicular activities that might impact the reduced gravity environment the experiments are exposed to. The monitoring system can detect both known and unknown vibratory disturbance activities. It can also perform trend analysis and prediction by analyzing past data over many increments (an increment usually lasts 6 months) collected onboard the station for selected disturbances. This feature can be used to monitor the health of onboard mechanical systems to detect and prevent potential systems failures. The monitoring system has two operating modes: online and offline. Both near real-time on-line vibratory disturbance detection and off-line detection and trend analysis are discussed in this paper.

Anatomic features of the neck as predictive markers of difficult direct laryngoscopy in men and women: A prospective study

PubMed Central

Chara, Liaskou; Eleftherios, Vouzounerakis; Maria, Moirasgenti; Anastasia, Trikoupi; Chryssoula, Staikou

2014-01-01

Background and Aims: Difficult airway assessment is based on various anatomic parameters of upper airway, much of it being concentrated on oral cavity and the pharyngeal structures. The diagnostic value of tests based on neck anatomy in predicting difficult laryngoscopy was assessed in this prospective, open cohort study. Methods: We studied 341 adult patients scheduled to receive general anaesthesia. Thyromental distance (TMD), sternomental distance (STMD), ratio of height to thyromental distance (RHTMD) and neck circumference (NC) were measured pre-operatively. The laryngoscopic view was classified according to the Cormack–Lehane Grade (1-4). Difficult laryngoscopy was defined as Cormack–Lehane Grade 3 or 4. The optimal cut-off points for each variable were identified by using receiver operating characteristic analysis. Sensitivity, specificity and positive predictive value and negative predictive value (NPV) were calculated for each test. Multivariate analysis with logistic regression, including all variables, was used to create a predictive model. Comparisons between genders were also performed. Results: Laryngoscopy was difficult in 12.6% of the patients. The cut-off values were: TMD ≤7 cm, STMD ≤15 cm, RHTMD >18.4 and NC >37.5 cm. The RHTMD had the highest sensitivity (88.4%) and NPV (95.2%), while TMD had the highest specificity (83.9%). The area under curve (AUC) for the TMD, STMD, RHTMD and NC was 0.63, 0.64, 0.62 and 0.54, respectively. The predictive model exhibited a higher and statistically significant diagnostic accuracy (AUC: 0.68, P < 0.001). Gender-specific cut-off points improved the predictive accuracy of NC in women (AUC: 0.65). Conclusions: The TMD, STMD, RHTMD and NC were found to be poor single predictors of difficult laryngoscopy, while a model including all four variables had a significant predictive accuracy. Among the studied tests, gender-specific cut-off points should be used for NC. PMID:24963183

Anatomic features of the neck as predictive markers of difficult direct laryngoscopy in men and women: A prospective study.

PubMed

Liaskou, Chara; Chara, Liaskou; Vouzounerakis, Eleftherios; Eleftherios, Vouzounerakis; Moirasgenti, Maria; Maria, Moirasgenti; Trikoupi, Anastasia; Anastasia, Trikoupi; Staikou, Chryssoula; Chryssoula, Staikou

2014-03-01

Difficult airway assessment is based on various anatomic parameters of upper airway, much of it being concentrated on oral cavity and the pharyngeal structures. The diagnostic value of tests based on neck anatomy in predicting difficult laryngoscopy was assessed in this prospective, open cohort study. We studied 341 adult patients scheduled to receive general anaesthesia. Thyromental distance (TMD), sternomental distance (STMD), ratio of height to thyromental distance (RHTMD) and neck circumference (NC) were measured pre-operatively. The laryngoscopic view was classified according to the Cormack-Lehane Grade (1-4). Difficult laryngoscopy was defined as Cormack-Lehane Grade 3 or 4. The optimal cut-off points for each variable were identified by using receiver operating characteristic analysis. Sensitivity, specificity and positive predictive value and negative predictive value (NPV) were calculated for each test. Multivariate analysis with logistic regression, including all variables, was used to create a predictive model. Comparisons between genders were also performed. Laryngoscopy was difficult in 12.6% of the patients. The cut-off values were: TMD ≤7 cm, STMD ≤15 cm, RHTMD >18.4 and NC >37.5 cm. The RHTMD had the highest sensitivity (88.4%) and NPV (95.2%), while TMD had the highest specificity (83.9%). The area under curve (AUC) for the TMD, STMD, RHTMD and NC was 0.63, 0.64, 0.62 and 0.54, respectively. The predictive model exhibited a higher and statistically significant diagnostic accuracy (AUC: 0.68, P < 0.001). Gender-specific cut-off points improved the predictive accuracy of NC in women (AUC: 0.65). The TMD, STMD, RHTMD and NC were found to be poor single predictors of difficult laryngoscopy, while a model including all four variables had a significant predictive accuracy. Among the studied tests, gender-specific cut-off points should be used for NC.

Experimental validation of a novel stictionless magnetorheological fluid isolator

NASA Astrophysics Data System (ADS)

Kelso, Shawn P.; Denoyer, Keith K.; Blankinship, Ross M.; Potter, Kenneth; Lindler, Jason E.

2003-07-01

Magnetorheological (MR) fluid damper design typically constitutes a piston/dashpot configuration. During reciprocation, the fluid is circulated through the device with the generated pressure providing viscous damping. In addition, the damper is also intended to accommodate off-axis loading; i.e., rotation moments and lateral loads orthogonal to the axis of operation. Typically two sets of seals, one where the piston shaft enters and exits the device and one between the piston and the cylinder wall, maintain alignment of the damper and seal the fluid from leaking. With MR fluid, these seals can act as sources of non-linear friction effects (stiction) and oftentimes possess a shorter lifespan due to the abrasive nature of the ferrous particles suspended in the fluid. Intelligently controlling damping forces must also accommodate the non-linear stiction behavior, which degrades performance. A new, unique MR fluid isolator was designed, fabricated and tested that directly addresses these concerns. The goal of this research was the development of a stiction-free MR isolator whose damping force can be predicted and precisely controlled. This paper presents experimental results for a prototype device and compares those results to model predictions.

Incorporating body-type (apple vs. pear) in STOP-BANG questionnaire improves its validity to detect OSA.

PubMed

Sangkum, Lisa; Klair, Ikrita; Limsuwat, Chok; Bent, Sabrina; Myers, Leann; Thammasitboon, Supat

2017-09-01

The aim of this study is to evaluate whether adding the item of "apple body type" to the STOP-BANG questionnaire enhances diagnostic performance of the questionnaire for detecting obstructive sleep apnea (OSA). Cross-sectional study. Sleep center setting. Two hundred and eight subjects who were referred for an evaluation of possible OSA at Tulane Comprehensive Sleep Center. The exclusion criteria were age<18years old, incomplete or absent questionnaire, incomplete body type identification, polysomnography (PSG) refusal, and pregnant women. STOP-BANG items and body type data were collected on the initial clinic visit. An overnight PSG was performed on every participant. Descriptive analyses of the demographic data and PSG variables were performed. The predictive parameters of STOP and STOP-BANG without and with body type score (STOP-Apple and STOPBANG-Apple) were compared. The STOP questionnaire's sensitivity/specificity/positive likelihood ratio (+LR) (cut-off=2) was 96%/11%/1.1, respectively whereas the STOP-Apple questionnaire (cut-off=3) was 88%/39%/1.5. The STOP-BANG's sensitivity/specificity/+LR (cut-off=3) was 96%/19%/1.2, respectively whereas the STOP-BANG-Apple questionnaire (cut-off=4) was 90%/39%/1.5. The area under the Receiver Operating Characteristic (ROC) curve of STOP-Apple was comparable to the STOP-BANG (P=0.25). The addition of the apple body type item to the STOP-BANG questionnaire in participants with a score≥3 led to increased specificity (67.4%), increased the odds ratio of having OSA of 2.5 (95% CI, 1.2-5.3) and odds ratio of having moderate-severe OSA of 4.7 (95% CI, 2.5-8.7). In the sleep center setting, adding the body type item to the STOP-BANG questionnaire improves not only clinical prediction for PSG confirmed OSA but also predicts moderate to severe of OSA. Published by Elsevier Inc.

Impact of underlap spacer region variation on electrostatic and analog performance of symmetrical high-k SOI FinFET at 20 nm channel length

NASA Astrophysics Data System (ADS)

Jain, Neeraj; Raj, Balwinder

2017-12-01

Continued scaling of CMOS technology to achieve high performance and low power consumption of semiconductor devices in the complex integrated circuits faces the degradation in terms of electrostatic integrity, short channel effects (SCEs), leakage currents, device variability and reliability etc. Nowadays, multigate structure has become the promising candidate to overcome these problems. SOI FinFET is one of the best multigate structures that has gained importance in all electronic design automation (EDA) industries due to its improved short channel effects (SCEs), because of its more effective gate-controlling capabilities. In this paper, our aim is to explore the sensitivity of underlap spacer region variation on the performance of SOI FinFET at 20 nm channel length. Electric field modulation is analyzed with spacer length variation and electrostatic performance is evaluated in terms of performance parameter like electron mobility, electric field, electric potential, sub-threshold slope (SS), ON current (I on), OFF current (I off) and I on/I off ratio. The potential benefits of SOI FinFET at drain-to-source voltage, V DS = 0.05 V and V DS = 0.7 V towards analog and RF design is also evaluated in terms of intrinsic gain (A V), output conductance (g d), trans-conductance (g m), gate capacitance (C gg), and cut-off frequency (f T = g m/2πC gg) with spacer region variations.

Value of high-sensitivity C-reactive protein assays in predicting atrial fibrillation recurrence: a systematic review and meta-analysis.

PubMed

Yo, Chia-Hung; Lee, Si-Huei; Chang, Shy-Shin; Lee, Matthew Chien-Hung; Lee, Chien-Chang

2014-02-20

We performed a systematic review and meta-analysis of studies on high-sensitivity C-reactive protein (hs-CRP) assays to see whether these tests are predictive of atrial fibrillation (AF) recurrence after cardioversion. Systematic review and meta-analysis. PubMed, EMBASE and Cochrane databases as well as a hand search of the reference lists in the retrieved articles from inception to December 2013. This review selected observational studies in which the measurements of serum CRP were used to predict AF recurrence. An hs-CRP assay was defined as any CRP test capable of measuring serum CRP to below 0.6 mg/dL. We summarised test performance characteristics with the use of forest plots, hierarchical summary receiver operating characteristic curves and bivariate random effects models. Meta-regression analysis was performed to explore the source of heterogeneity. We included nine qualifying studies comprising a total of 347 patients with AF recurrence and 335 controls. A CRP level higher than the optimal cut-off point was an independent predictor of AF recurrence after cardioversion (summary adjusted OR: 3.33; 95% CI 2.10 to 5.28). The estimated pooled sensitivity and specificity for hs-CRP was 71.0% (95% CI 63% to 78%) and 72.0% (61% to 81%), respectively. Most studies used a CRP cut-off point of 1.9 mg/L to predict long-term AF recurrence (77% sensitivity, 65% specificity), and 3 mg/L to predict short-term AF recurrence (73% sensitivity, 71% specificity). hs-CRP assays are moderately accurate in predicting AF recurrence after successful cardioversion.

Computational Evaluation of Inlet Distortion on an Ejector Powered Hybrid Wing Body at Takeoff and Landing Conditions

NASA Technical Reports Server (NTRS)

Tompkins, Daniel M.; Sexton, Matthew R.; Mugica, Edward A.; Beyar, Michael D.; Schuh, Michael J.; Stremel, Paul M.; Deere, Karen A.; McMillin, Naomi; Carter, Melissa B.

2016-01-01

Due to the aft, upper surface engine location on the Hybrid Wing Body (HWB) planform, there is potential to shed vorticity and separated wakes into the engine when the vehicle is operated at off-design conditions and corners of the envelope required for engine and airplane certification. CFD simulations were performed of the full-scale reference propulsion system, operating at a range of inlet flow rates, flight speeds, altitudes, angles of attack, and angles of sideslip to identify the conditions which produce the largest distortion and lowest pressure recovery. Pretest CFD was performed by NASA and Boeing, using multiple CFD codes, with various turbulence models. These data were used to make decisions regarding model integration, characterize inlet flow distortion patterns, and help define the wind tunnel test matrix. CFD was also performed post-test; when compared with test data, it was possible to make comparisons between measured model-scale and predicted full-scale distortion levels. This paper summarizes these CFD analyses.

Assessing and predicting drug-induced anticholinergic risks: an integrated computational approach.

PubMed

Xu, Dong; Anderson, Heather D; Tao, Aoxiang; Hannah, Katia L; Linnebur, Sunny A; Valuck, Robert J; Culbertson, Vaughn L

2017-11-01

Anticholinergic (AC) adverse drug events (ADEs) are caused by inhibition of muscarinic receptors as a result of designated or off-target drug-receptor interactions. In practice, AC toxicity is assessed primarily based on clinician experience. The goal of this study was to evaluate a novel concept of integrating big pharmacological and healthcare data to assess clinical AC toxicity risks. AC toxicity scores (ATSs) were computed using drug-receptor inhibitions identified through pharmacological data screening. A longitudinal retrospective cohort study using medical claims data was performed to quantify AC clinical risks. ATS was compared with two previously reported toxicity measures. A quantitative structure-activity relationship (QSAR) model was established for rapid assessment and prediction of AC clinical risks. A total of 25 common medications, and 575,228 exposed and unexposed patients were analyzed. Our data indicated that ATS is more consistent with the trend of AC outcomes than other toxicity methods. Incorporating drug pharmacokinetic parameters to ATS yielded a QSAR model with excellent correlation to AC incident rate ( R 2 = 0.83) and predictive performance (cross validation Q 2 = 0.64). Good correlation and predictive performance ( R 2 = 0.68/ Q 2 = 0.29) were also obtained for an M2 receptor-specific QSAR model and tachycardia, an M2 receptor-specific ADE. Albeit using a small medication sample size, our pilot data demonstrated the potential and feasibility of a new computational AC toxicity scoring approach driven by underlying pharmacology and big data analytics. Follow-up work is under way to further develop the ATS scoring approach and clinical toxicity predictive model using a large number of medications and clinical parameters.

A first principles based methodology for design of axial compressor configurations

NASA Astrophysics Data System (ADS)

Iyengar, Vishwas

Axial compressors are widely used in many aerodynamic applications. The design of an axial compressor configuration presents many challenges. Until recently, compressor design was done using 2-D viscous flow analyses that solve the flow field around cascades or in meridional planes or 3-D inviscid analyses. With the advent of modern computational methods it is now possible to analyze the 3-D viscous flow and accurately predict the performance of 3-D multistage compressors. It is necessary to retool the design methodologies to take advantage of the improved accuracy and physical fidelity of these advanced methods. In this study, a first-principles based multi-objective technique for designing single stage compressors is described. The study accounts for stage aerodynamic characteristics, rotor-stator interactions and blade elastic deformations. A parametric representation of compressor blades that include leading and trailing edge camber line angles, thickness and camber distributions was used in this study. A design of experiment approach is used to reduce the large combinations of design variables into a smaller subset. A response surface method is used to approximately map the output variables as a function of design variables. An optimized configuration is determined as the extremum of all extrema. This method has been applied to a rotor-stator stage similar to NASA Stage 35. The study has two parts: a preliminary study where a limited number of design variables were used to give an understanding of the important design variables for subsequent use, and a comprehensive application of the methodology where a larger, more complete set of design variables are used. The extended methodology also attempts to minimize the acoustic fluctuations at the rotor-stator interface by considering a rotor-wake influence coefficient (RWIC). Results presented include performance map calculations at design and off-design speed along with a detailed visualization of the flow field at design and off-design conditions. The present methodology provides a way to systematically screening through the plethora of design variables. By selecting the most influential design parameters and by optimizing the blade leading edge and trailing edge mean camber line angles, phenomenon's such as tip blockages, blade-to-blade shock structures and other loss mechanisms can be weakened or alleviated. It is found that these changes to the configuration can have a beneficial effect on total pressure ratio and stage adiabatic efficiency, thereby improving the performance of the axial compression system. Aeroacoustic benefits were found by minimizing the noise generating mechanisms associated with rotor wake-stator interactions. The new method presented is reliable, low time cost, and easily applicable to industry daily design optimization of turbomachinery blades.

Numerical Simulation of Complex Turbomachinery Flows

NASA Technical Reports Server (NTRS)

Chernobrovkin, A. A.; Lakshiminarayana, B.

1999-01-01

An unsteady, multiblock, Reynolds Averaged Navier Stokes solver based on Runge-Kutta scheme and Pseudo-time step for turbo-machinery applications was developed. The code was validated and assessed against analytical and experimental data. It was used to study a variety of physical mechanisms of unsteady, three-dimensional, turbulent, transitional, and cooling flows in compressors and turbines. Flow over a cylinder has been used to study effects of numerical aspects on accuracy of prediction of wake decay and transition, and to modify K-epsilon models. The following simulations have been performed: (a) Unsteady flow in a compressor cascade: Three low Reynolds number turbulence models have been assessed and data compared with Euler/boundary layer predictions. Major flow features associated with wake induced transition were predicted and studied; (b) Nozzle wake-rotor interaction in a turbine: Results compared to LDV data in design and off-design conditions, and cause and effect of unsteady flow in turbine rotors were analyzed; (c) Flow in the low-pressure turbine: Assessed capability of the code to predict transitional, attached and separated flows at a wide range of low Reynolds numbers and inlet freestream turbulence intensity. Several turbulence and transition models have been employed and comparisons made to experiments; (d) leading edge film cooling at compound angle: Comparisons were made with experiments, and the flow physics of the associated vortical structures were studied; and (e) Tip leakage flow in a turbine. The physics of the secondary flow in a rotor was studied and sources of loss identified.

Circularly Polarized Microwave Antenna Element with Very Low Off-Axis Cross-Polarization

NASA Technical Reports Server (NTRS)

Greem. David; DuToit, Cornelis

2013-01-01

The goal of this work was to improve off-axis cross-polarization performance and ease of assembly of a circularly polarized microwave antenna element. To ease assembly, the initial design requirement of Hexweb support for the internal circuit part, as well as the radiating disks, was eliminated. There is a need for different plating techniques to improve soldering. It was also desirable to change the design to eliminate soldering as well as the need to use the Hexweb support. Thus, a technique was developed to build the feed without using solder, solving the lathing and soldering issue. Internal parts were strengthened by adding curvature to eliminate Hexweb support, and in the process, the new geometries of the internal parts opened the way for improving the off-axis cross-polarization performance as well. The radiating disks curvatures were increased for increased strength, but it was found that this also improved crosspolarization. Optimization of the curvatures leads to very low off-axis cross-polarization. The feed circuit was curved into a cylinder for improved strength, eliminating Hexweb support. An aperture coupling feed mechanism eliminated the need for feed pins to the disks, which would have required soldering. The aperture coupling technique also improves cross-polarization performance by effectively exciting the radiating disks very close to the antenna s central axis of symmetry. Because of the shape of the parts, it allowed for an all-aluminum design bolted together and assembled with no solder needed. The advantage of a solderless design is that the reliability is higher, with no single-point failure (solder), and no need for special plating techniques in order to solder the unit together. The shapes (curved or round) make for a more robust build without extra support materials, as well as improved offaxis cross-polarization.

3D Protein structure prediction with genetic tabu search algorithm

PubMed Central

2010-01-01

Background Protein structure prediction (PSP) has important applications in different fields, such as drug design, disease prediction, and so on. In protein structure prediction, there are two important issues. The first one is the design of the structure model and the second one is the design of the optimization technology. Because of the complexity of the realistic protein structure, the structure model adopted in this paper is a simplified model, which is called off-lattice AB model. After the structure model is assumed, optimization technology is needed for searching the best conformation of a protein sequence based on the assumed structure model. However, PSP is an NP-hard problem even if the simplest model is assumed. Thus, many algorithms have been developed to solve the global optimization problem. In this paper, a hybrid algorithm, which combines genetic algorithm (GA) and tabu search (TS) algorithm, is developed to complete this task. Results In order to develop an efficient optimization algorithm, several improved strategies are developed for the proposed genetic tabu search algorithm. The combined use of these strategies can improve the efficiency of the algorithm. In these strategies, tabu search introduced into the crossover and mutation operators can improve the local search capability, the adoption of variable population size strategy can maintain the diversity of the population, and the ranking selection strategy can improve the possibility of an individual with low energy value entering into next generation. Experiments are performed with Fibonacci sequences and real protein sequences. Experimental results show that the lowest energy obtained by the proposed GATS algorithm is lower than that obtained by previous methods. Conclusions The hybrid algorithm has the advantages from both genetic algorithm and tabu search algorithm. It makes use of the advantage of multiple search points in genetic algorithm, and can overcome poor hill-climbing capability in the conventional genetic algorithm by using the flexible memory functions of TS. Compared with some previous algorithms, GATS algorithm has better performance in global optimization and can predict 3D protein structure more effectively. PMID:20522256

Prediction of Dementia in Primary Care Patients

PubMed Central

Jessen, Frank; Wiese, Birgitt; Bickel, Horst; Eiffländer-Gorfer, Sandra; Fuchs, Angela; Kaduszkiewicz, Hanna; Köhler, Mirjam; Luck, Tobias; Mösch, Edelgard; Pentzek, Michael; Riedel-Heller, Steffi G.; Wagner, Michael; Weyerer, Siegfried; Maier, Wolfgang; van den Bussche, Hendrik

2011-01-01

Background Current approaches for AD prediction are based on biomarkers, which are however of restricted availability in primary care. AD prediction tools for primary care are therefore needed. We present a prediction score based on information that can be obtained in the primary care setting. Methodology/Principal Findings We performed a longitudinal cohort study in 3.055 non-demented individuals above 75 years recruited via primary care chart registries (Study on Aging, Cognition and Dementia, AgeCoDe). After the baseline investigation we performed three follow-up investigations at 18 months intervals with incident dementia as the primary outcome. The best set of predictors was extracted from the baseline variables in one randomly selected half of the sample. This set included age, subjective memory impairment, performance on delayed verbal recall and verbal fluency, on the Mini-Mental-State-Examination, and on an instrumental activities of daily living scale. These variables were aggregated to a prediction score, which achieved a prediction accuracy of 0.84 for AD. The score was applied to the second half of the sample (test cohort). Here, the prediction accuracy was 0.79. With a cut-off of at least 80% sensitivity in the first cohort, 79.6% sensitivity, 66.4% specificity, 14.7% positive predictive value (PPV) and 97.8% negative predictive value of (NPV) for AD were achieved in the test cohort. At a cut-off for a high risk population (5% of individuals with the highest risk score in the first cohort) the PPV for AD was 39.1% (52% for any dementia) in the test cohort. Conclusions The prediction score has useful prediction accuracy. It can define individuals (1) sensitively for low cost-low risk interventions, or (2) more specific and with increased PPV for measures of prevention with greater costs or risks. As it is independent of technical aids, it may be used within large scale prevention programs. PMID:21364746

Prediction of dementia in primary care patients.

PubMed

Jessen, Frank; Wiese, Birgitt; Bickel, Horst; Eiffländer-Gorfer, Sandra; Fuchs, Angela; Kaduszkiewicz, Hanna; Köhler, Mirjam; Luck, Tobias; Mösch, Edelgard; Pentzek, Michael; Riedel-Heller, Steffi G; Wagner, Michael; Weyerer, Siegfried; Maier, Wolfgang; van den Bussche, Hendrik

2011-02-18

Current approaches for AD prediction are based on biomarkers, which are however of restricted availability in primary care. AD prediction tools for primary care are therefore needed. We present a prediction score based on information that can be obtained in the primary care setting. We performed a longitudinal cohort study in 3.055 non-demented individuals above 75 years recruited via primary care chart registries (Study on Aging, Cognition and Dementia, AgeCoDe). After the baseline investigation we performed three follow-up investigations at 18 months intervals with incident dementia as the primary outcome. The best set of predictors was extracted from the baseline variables in one randomly selected half of the sample. This set included age, subjective memory impairment, performance on delayed verbal recall and verbal fluency, on the Mini-Mental-State-Examination, and on an instrumental activities of daily living scale. These variables were aggregated to a prediction score, which achieved a prediction accuracy of 0.84 for AD. The score was applied to the second half of the sample (test cohort). Here, the prediction accuracy was 0.79. With a cut-off of at least 80% sensitivity in the first cohort, 79.6% sensitivity, 66.4% specificity, 14.7% positive predictive value (PPV) and 97.8% negative predictive value of (NPV) for AD were achieved in the test cohort. At a cut-off for a high risk population (5% of individuals with the highest risk score in the first cohort) the PPV for AD was 39.1% (52% for any dementia) in the test cohort. The prediction score has useful prediction accuracy. It can define individuals (1) sensitively for low cost-low risk interventions, or (2) more specific and with increased PPV for measures of prevention with greater costs or risks. As it is independent of technical aids, it may be used within large scale prevention programs.

Is the whole more than the sum of its parts? Evolutionary trade-offs between burst and sustained locomotion in lacertid lizards.

PubMed

Vanhooydonck, B; James, R S; Tallis, J; Aerts, P; Tadic, Z; Tolley, K A; Measey, G J; Herrel, A

2014-02-22

Trade-offs arise when two functional traits impose conflicting demands on the same design trait. Consequently, excellence in one comes at the cost of performance in the other. One of the most widely studied performance trade-offs is the one between sprint speed and endurance. Although biochemical, physiological and (bio)mechanical correlates of either locomotor trait conflict with each other, results at the whole-organism level are mixed. Here, we test whether burst (speed, acceleration) and sustained locomotion (stamina) trade off at both the isolated muscle and whole-organism level among 17 species of lacertid lizards. In addition, we test for a mechanical link between the organismal and muscular (power output, fatigue resistance) performance traits. We find weak evidence for a trade-off between burst and sustained locomotion at the whole-organism level; however, there is a significant trade-off between muscle power output and fatigue resistance in the isolated muscle level. Variation in whole-animal sprint speed can be convincingly explained by variation in muscular power output. The variation in locomotor stamina at the whole-organism level does not relate to the variation in muscle fatigue resistance, suggesting that whole-organism stamina depends not only on muscle contractile performance but probably also on the performance of the circulatory and respiratory systems.

Is the whole more than the sum of its parts? Evolutionary trade-offs between burst and sustained locomotion in lacertid lizards

PubMed Central

Vanhooydonck, B.; James, R. S.; Tallis, J.; Aerts, P.; Tadic, Z.; Tolley, K. A.; Measey, G. J.; Herrel, A.

2014-01-01

Trade-offs arise when two functional traits impose conflicting demands on the same design trait. Consequently, excellence in one comes at the cost of performance in the other. One of the most widely studied performance trade-offs is the one between sprint speed and endurance. Although biochemical, physiological and (bio)mechanical correlates of either locomotor trait conflict with each other, results at the whole-organism level are mixed. Here, we test whether burst (speed, acceleration) and sustained locomotion (stamina) trade off at both the isolated muscle and whole-organism level among 17 species of lacertid lizards. In addition, we test for a mechanical link between the organismal and muscular (power output, fatigue resistance) performance traits. We find weak evidence for a trade-off between burst and sustained locomotion at the whole-organism level; however, there is a significant trade-off between muscle power output and fatigue resistance in the isolated muscle level. Variation in whole-animal sprint speed can be convincingly explained by variation in muscular power output. The variation in locomotor stamina at the whole-organism level does not relate to the variation in muscle fatigue resistance, suggesting that whole-organism stamina depends not only on muscle contractile performance but probably also on the performance of the circulatory and respiratory systems. PMID:24403334

Boredom begets creativity: A solution to the exploitation-exploration trade-off in predictive coding.

PubMed

Gomez-Ramirez, Jaime; Costa, Tommaso

2017-12-01

Here we investigate whether systems that minimize prediction error e.g. predictive coding, can also show creativity, or on the contrary, prediction error minimization unqualifies for the design of systems that respond in creative ways to non-recurrent problems. We argue that there is a key ingredient that has been overlooked by researchers that needs to be incorporated to understand intelligent behavior in biological and technical systems. This ingredient is boredom. We propose a mathematical model based on the Black-Scholes-Merton equation which provides mechanistic insights into the interplay between boredom and prediction pleasure as the key drivers of behavior. Copyright © 2017 Elsevier B.V. All rights reserved.

Are different cut-off values of liver stiffness assessed by transient elastography according to the etiology of liver cirrhosis for predicting significant esophageal varices?

PubMed

Sporea, Ioan; Raţiu, Iulia; Bota, Simona; Şirli, Roxana; Jurchiş, Ana

2013-06-01

To determine if liver stiffness (LS) measurements by means of Transient Elastography (TE) vary according to the etiology of the underlying liver cirrhosis and to find if there are different TE cut-off values able to predict the presence of significant EV in alcoholic vs. viral etiology of cirrhosis. This retrospective study included patients diagnosed with liver cirrhosis of viral or alcoholic etiology. All patients were evaluated by means of TE (FibroScan) and upper gastrointestinal endoscopy. We performed 10 LS measurements in each patient and a median value expressed in kiloPascals (kPa) was calculated. Only those with a SR >/= 60% and an IQR<30% were considered as reliable MS measurements. According to the presence of EV the patients were divided in two categories: without significant EV and patients with significant EV (at least grade 2). The study included 697 cirrhotic patients with reliable LS measurements. The median LS values assessed by TE were significantly higher in cirrhotic patients with alcoholic etiology as compared with those with viral etiology of liver disease: 41 kPa vs. 21.1 kPa, p<0.0001. In the entire cohort of cirrhotic patients, LS assessed by means of TE for a cut-off value >29.5 kPa, had 77.5% sensitivity and 86.9% specificity for predicting the presence of significant EV (AUROC=0.871). The best LS cut-off value for predicting the presence of significant EV was higher in alcoholic cirrhosis as compared with those with viral etiology of liver cirrhosis: 32.5 kPa (AUROC=0.836) vs. 24.8 kPa (AUROC=0.867). LS cut-off values assessed by TE for predicting significant EV are significantly higher in patients with alcoholic cirrhosis as compared with patients with liver cirrhosis of viral etiology.

Prediction of circulation control performance characteristics for Super STOL and STOL applications

NASA Astrophysics Data System (ADS)

Naqvi, Messam Abbas

The rapid air travel growth during the last three decades, has resulted in runway congestion at major airports. The current airports infrastructure will not be able to support the rapid growth trends expected in the next decade. Changes or upgrades in infrastructure alone would not be able to satisfy the growth requirements, and new airplane concepts such as the NASA proposed Super Short Takeoff and Landing and Extremely Short Takeoff & Landing (ESTOL) are being vigorously pursued. Aircraft noise pollution during Takeoff & Landing is another serious concern and efforts are aimed to reduce the airframe noise produced by Conventional High Lift Devices during Takeoff & Landing. Circulation control technology has the prospect of being a good alternative to resolve both the aforesaid issues. Circulation control airfoils are not only capable of producing very high values of lift (Cl values in excess of 8.0) at zero degree angle of attack, but also eliminate the noise generated by the conventional high lift devices and their associated weight penalty as well as their complex operation and storage. This will ensure not only satisfying the small takeoff and landing distances, but minimal acoustic signature in accordance with FAA requirements. The Circulation Control relies on the tendency of an emanating wall jet to independently control the circulation and lift on an airfoil. Unlike, conventional airfoil where rear stagnation point is located at the sharp trailing edge, circulation control airfoils possess a round trailing edge, therefore the rear stagnation point is free to move. The location of rear stagnation point is controlled by the blown jet momentum. This provides a secondary control in the form of jet momentum with which the lift generated can be controlled rather the only available control of incidence (angle of attack) in case of conventional airfoils. The use of Circulation control despite its promising potential has been limited only to research applications due to the lack of a simple prediction capability. This research effort was focused on the creation of a rapid prediction capability of Circulation Control Aerodynamic Characteristics which could help designers with rapid performance estimates for design space exploration. A morphological matrix was created with the available set of options which could be chosen to create this prediction capability starting with purely analytical physics based modeling to high fidelity CFD codes. Based on the available constraints, and desired accuracy meta-models have been created around the two dimensional circulation control performance results computed using Navier Stokes Equations (Computational Fluid Dynamics). DSS2, a two dimensional RANS code written by Professor Lakshmi Sankar was utilized for circulation control airfoil characteristics. The CFD code was first applied to the NCCR 1510-7607N airfoil to validate the model with available experimental results. It was then applied to compute the results of a fractional factorial design of experiments array. Metamodels were formulated using the neural networks to the results obtained from the Design of Experiments. Additional validation runs were performed to validate the model predictions. Metamodels are not only capable of rapid performance prediction, but also help generate the relation trends of response matrices with control variables and capture the complex interactions between control variables. Quantitative as well as qualitative assessments of results were performed by computation of aerodynamic forces & moments and flow field visualizations. Wing characteristics in three dimensions were obtained by integration over the whole wing using Prandtl's Wing Theory. The baseline Super STOL configuration [3] was then analyzed with the application of circulation control technology. The desired values of lift and drag to achieve the target values of Takeoff & Landing performance were compared with the optimal configurations obtained by the model. The same optimal configurations were then subjected to Super STOL cruise conditions to perform a trade off analysis between Takeoff and Cruise Performance. Supercritical airfoils modified for circulation control were also thoroughly analyzed for Takeoff and Cruise performance and may constitute a viable option for Super STOL & STOL Designs. The prediction capability produced by this research effort can be integrated with the current conceptual aircraft modeling & simulation framework. The prediction tool is applicable within the selected ranges of each variable, but methodology and formulation scheme adopted can be applied to any other design space exploration.

Coordinating the Design and Management of Heterogeneous Datacenter Resources

ERIC Educational Resources Information Center

Guevara, Marisabel

2014-01-01

Heterogeneous design presents an opportunity to improve energy efficiency but raises a challenge in management. Whereas prior work separates the two, we coordinate heterogeneous design and management. We present a market-based resource allocation mechanism that navigates the performance and power trade-offs of heterogeneous architectures. Given…

Concentrating phenolic acids from Lonicera japonica by nanofiltration technology

NASA Astrophysics Data System (ADS)

Li, Cunyu; Ma, Yun; Li, Hongyang; Peng, Guoping

2017-03-01

Response surface analysis methodology was used to optimize the concentrate process of phenolic acids from Lonicera japonica by nanofiltration technique. On the basis of the influences of pressure, temperature and circulating volume, the retention rate of neochlorogenic acid, chlorogenic acid and 4-dicaffeoylquinic acid were selected as index, molecular weight cut-off of nanofiltration membrane, concentration and pH were selected as influencing factors during concentrate process. The experiment mathematical model was arranged according to Box-Behnken central composite experiment design. The optimal concentrate conditions were as following: nanofiltration molecular weight cut-off, 150 Da; solutes concentration, 18.34 µg/mL; pH, 4.26. The predicted value of retention rate was 97.99% under the optimum conditions, and the experimental value was 98.03±0.24%, which was in accordance with the predicted value. These results demonstrate that the combination of Box-Behnken design and response surface analysis can well optimize the concentrate process of Lonicera japonica water-extraction by nanofiltration, and the results provide the basis for nanofiltration concentrate for heat-sensitive traditional Chinese medicine.

Wide-field-of-view millimeter-wave telescope design with ultra-low cross-polarization

NASA Astrophysics Data System (ADS)

Bernacki, Bruce E.; Kelly, James F.; Sheen, David; Hatchell, Brian; Valdez, Patrick; Tedeschi, Jonathan; Hall, Thomas; McMakin, Douglas

2012-06-01

As millimeter-wave arrays become available, off-axis imaging performance of the fore optics increases in importance due to the relatively large physical extent of the arrays. Typically, simple optical telescope designs are adapted to millimeter-wave imaging but single-mirror spherical or classic conic designs cannot deliver adequate image quality except near the optical axis. Since millimeter-wave designs are quasi-optical, optical ray tracing and commercial design software can be used to optimize designs to improve off-axis imaging as well as minimize cross-polarization. Methods that obey the Dragone-Mizuguchi condition for the design of reflective millimeter-wave telescopes with low cross-polarization also provide additional degrees of freedom that offer larger fields of view than possible with single-reflector designs. Dragone's graphical design method does not lend itself readily to computer-based optical design approaches, but subsequent authors expanded on Dragone's geometric design approach with analytic expressions that describe the location, shape, off-axis height and tilt of the telescope elements that satisfy Dragone's design rules and can be used as a first-order design for subsequent computer-based design and optimization. We investigate two design variants that obey the Dragone-Mizuguchi conditions that exhibit ultra-low cross-polarization and a large diffraction-limited field of view well suited to millimeter-wave imaging arrays.

Threshold value of home pulse pressure predicting arterial stiffness in patients with type 2 diabetes: KAMOGAWA-HBP study.

PubMed

Kitagawa, Noriyuki; Ushigome, Emi; Matsumoto, Shinobu; Oyabu, Chikako; Ushigome, Hidetaka; Yokota, Isao; Asano, Mai; Tanaka, Muhei; Yamazaki, Masahiro; Fukui, Michiaki

2018-03-01

This cross-sectional multicenter study was designed to evaluate the threshold value of home pulse pressure (PP) and home systolic blood pressure (SBP) predicting the arterial stiffness in 876 patients with type 2 diabetes. We measured the area under the receiver-operating characteristic curve (AUC) and estimated the ability of home PP to identify arterial stiffness using Youden-Index defined cut-off point. The arterial stiffness was measured using the brachial-ankle pulse wave velocity (baPWV). AUC for arterial stiffness in morning PP was significantly greater than that in morning SBP (P < .001). AUC for arterial stiffness in evening PP was also significantly greater than that in evening SBP (P < .001). The optimal cut-off points for morning PP and evening PP, which predicted arterial stiffness, were 54.6 and 56.9 mm Hg, respectively. Our findings indicate that we should pay more attention to increased home PP in patients with type 2 diabetes. ©2018 Wiley Periodicals, Inc.

From sequence to enzyme mechanism using multi-label machine learning.

PubMed

De Ferrari, Luna; Mitchell, John B O

2014-05-19

In this work we predict enzyme function at the level of chemical mechanism, providing a finer granularity of annotation than traditional Enzyme Commission (EC) classes. Hence we can predict not only whether a putative enzyme in a newly sequenced organism has the potential to perform a certain reaction, but how the reaction is performed, using which cofactors and with susceptibility to which drugs or inhibitors, details with important consequences for drug and enzyme design. Work that predicts enzyme catalytic activity based on 3D protein structure features limits the prediction of mechanism to proteins already having either a solved structure or a close relative suitable for homology modelling. In this study, we evaluate whether sequence identity, InterPro or Catalytic Site Atlas sequence signatures provide enough information for bulk prediction of enzyme mechanism. By splitting MACiE (Mechanism, Annotation and Classification in Enzymes database) mechanism labels to a finer granularity, which includes the role of the protein chain in the overall enzyme complex, the method can predict at 96% accuracy (and 96% micro-averaged precision, 99.9% macro-averaged recall) the MACiE mechanism definitions of 248 proteins available in the MACiE, EzCatDb (Database of Enzyme Catalytic Mechanisms) and SFLD (Structure Function Linkage Database) databases using an off-the-shelf K-Nearest Neighbours multi-label algorithm. We find that InterPro signatures are critical for accurate prediction of enzyme mechanism. We also find that incorporating Catalytic Site Atlas attributes does not seem to provide additional accuracy. The software code (ml2db), data and results are available online at http://sourceforge.net/projects/ml2db/ and as supplementary files.

Development and Applications of a Stage Stacking Procedure

NASA Technical Reports Server (NTRS)

Kulkarni, Sameer; Celestina, Mark L.; Adamczyk, John J.

2012-01-01

The preliminary design of multistage axial compressors in gas turbine engines is typically accomplished with mean-line methods. These methods, which rely on empirical correlations, estimate compressor performance well near the design point, but may become less reliable off-design. For land-based applications of gas turbine engines, off-design performance estimates are becoming increasingly important, as turbine plant operators desire peaking or load-following capabilities and hot-day operability. The current work develops a one-dimensional stage stacking procedure, including a newly defined blockage term, which is used to estimate the off-design performance and operability range of a 13-stage axial compressor used in a power generating gas turbine engine. The new blockage term is defined to give mathematical closure on static pressure, and values of blockage are shown to collapse to curves as a function of stage inlet flow coefficient and corrected shaft speed. In addition to these blockage curves, the stage stacking procedure utilizes stage characteristics of ideal work coefficient and adiabatic efficiency. These curves are constructed using flow information extracted from computational fluid dynamics (CFD) simulations of groups of stages within the compressor. Performance estimates resulting from the stage stacking procedure are shown to match the results of CFD simulations of the entire compressor to within 1.6% in overall total pressure ratio and within 0.3 points in overall adiabatic efficiency. Utility of the stage stacking procedure is demonstrated by estimation of the minimum corrected speed which allows stable operation of the compressor. Further utility of the stage stacking procedure is demonstrated with a bleed sensitivity study, which estimates a bleed schedule to expand the compressors operating range.

Toward better public health reporting using existing off the shelf approaches: The value of medical dictionaries in automated cancer detection using plaintext medical data.

PubMed

Kasthurirathne, Suranga N; Dixon, Brian E; Gichoya, Judy; Xu, Huiping; Xia, Yuni; Mamlin, Burke; Grannis, Shaun J

2017-05-01

Existing approaches to derive decision models from plaintext clinical data frequently depend on medical dictionaries as the sources of potential features. Prior research suggests that decision models developed using non-dictionary based feature sourcing approaches and "off the shelf" tools could predict cancer with performance metrics between 80% and 90%. We sought to compare non-dictionary based models to models built using features derived from medical dictionaries. We evaluated the detection of cancer cases from free text pathology reports using decision models built with combinations of dictionary or non-dictionary based feature sourcing approaches, 4 feature subset sizes, and 5 classification algorithms. Each decision model was evaluated using the following performance metrics: sensitivity, specificity, accuracy, positive predictive value, and area under the receiver operating characteristics (ROC) curve. Decision models parameterized using dictionary and non-dictionary feature sourcing approaches produced performance metrics between 70 and 90%. The source of features and feature subset size had no impact on the performance of a decision model. Our study suggests there is little value in leveraging medical dictionaries for extracting features for decision model building. Decision models built using features extracted from the plaintext reports themselves achieve comparable results to those built using medical dictionaries. Overall, this suggests that existing "off the shelf" approaches can be leveraged to perform accurate cancer detection using less complex Named Entity Recognition (NER) based feature extraction, automated feature selection and modeling approaches. Copyright © 2017 Elsevier Inc. All rights reserved.

Study of the Correlation between the Performances of Lunar Vehicle Wheels Predicted by the Nepean Wheeled Vehicle Performance Model and Test Data

NASA Technical Reports Server (NTRS)

Wong, J. Y.; Asnani, V. M.

2008-01-01

This paper describes the results of a study of the correlation between the performances of wheels for lunar vehicles predicted using the Nepean wheeled vehicle performance model (NWVPM), developed under the auspices of Vehicle Systems Development Corporation, Ottawa, Canada, and the corresponding test data presented in Performance evaluation of wheels for lunar vehicles , Technical Report M-70-2, prepared for George C. Marshall Space Flight Center, National Aeronautics and Space Administration (NASA), USA, by the US Army Engineer Waterways Experiment Station (WES). The NWVPM was originally developed for design and performance evaluation of terrestrial off-road wheeled vehicles. The purpose of this study is to assess the potential of the NWVPM for evaluating wheel candidates for the new generation of extra-terrestrial vehicles. Two versions of a wire-mesh wheel and a hoop-spring wheel, which were considered as candidates for lunar roving vehicles for the NASA Apollo program in the late 1960s, together with a pneumatic wheel were examined in this study. The tractive performances of these wheels and of a 464 test vehicle with the pneumatic wheels on air-dry sand were predicted using the NWVPM and compared with the corresponding test data obtained under Earth s gravity and previously documented in the above-named report. While test data on wheel or vehicle performances obtained under Earth s gravity may not necessarily be representative of those on extra-terrestrial bodies, because of the differences in gravity and in environmental conditions, such as atmospheric pressure, it is still a valid approach to use test data obtained under Earth s gravity to evaluate the predictive capability of the NWVPM and its potential applications to predicting wheel or wheeled rover performances on extra-terrestrial bodies. Results of this study show that, using the ratio (P20/W) of the drawbar pull to normal load at 20 per cent slip as a performance indicator, there is a reasonable correlation between the predictions and experimental data. This indicates that the NWVPM has the potential as an engineering tool for evaluating wheel candidates for a future generation of extra-terrestrial vehicles, provided that appropriate input data are available.

Structural Performance of a Hybrid FRP-Aluminum Modular Triangular Truss System Subjected to Various Loading Conditions

PubMed Central

Zhang, Dongdong; Huang, Yaxin; Zhao, Qilin; Li, Fei; Gao, Yifeng

2014-01-01

A novel hybrid FRP-aluminum truss system has been employed in a two-rut modular bridge superstructure composed of twin inverted triangular trusses. The actual flexural behavior of a one-rut truss has been previously investigated under the on-axis loading test; however, the structural performance of the one-rut truss subjected to an off-axis load is still not fully understood. In this paper, a geometrical linear finite element model is introduced and validated by the on-axis loading test; the structural performance of the one-rut truss subjected to off-axis load was numerically obtained; the dissimilarities of the structural performance between the two different loading cases are investigated in detail. The results indicated that (1) the structural behavior of the off-axis load differs from that of the on-axis load, and the off-axis load is the critical loading condition controlling the structural performance of the triangular truss; (2) under the off-axis load, the FRP trussed members and connectors bear certain out-of-plane bending moments and are subjected to a complicated stress state; and (3) the stress state of these members does not match that of the initial design, and optimization for the redesign of these members is needed, especially for the pretightened teeth connectors. PMID:25254254

Ares I-X Launch Abort System, Crew Module, and Upper Stage Simulator Vibroacoustic Flight Data Evaluation, Comparison to Predictions, and Recommendations for Adjustments to Prediction Methodology and Assumptions

NASA Technical Reports Server (NTRS)

Smith, Andrew; Harrison, Phil

2010-01-01

The National Aeronautics and Space Administration (NASA) Constellation Program (CxP) has identified a series of tests to provide insight into the design and development of the Crew Launch Vehicle (CLV) and Crew Exploration Vehicle (CEV). Ares I-X was selected as the first suborbital development flight test to help meet CxP objectives. The Ares I-X flight test vehicle (FTV) is an early operational model of CLV, with specific emphasis on CLV and ground operation characteristics necessary to meet Ares I-X flight test objectives. The in-flight part of the test includes a trajectory to simulate maximum dynamic pressure during flight and perform a stage separation of the Upper Stage Simulator (USS) from the First Stage (FS). The in-flight test also includes recovery of the FS. The random vibration response from the ARES 1-X flight will be reconstructed for a few specific locations that were instrumented with accelerometers. This recorded data will be helpful in validating and refining vibration prediction tools and methodology. Measured vibroacoustic environments associated with lift off and ascent phases of the Ares I-X mission will be compared with pre-flight vibration predictions. The measured flight data was given as time histories which will be converted into power spectral density plots for comparison with the maximum predicted environments. The maximum predicted environments are documented in the Vibroacoustics and Shock Environment Data Book, AI1-SYS-ACOv4.10 Vibration predictions made using statistical energy analysis (SEA) VAOne computer program will also be incorporated in the comparisons. Ascent and lift off measured acoustics will also be compared to predictions to assess whether any discrepancies between the predicted vibration levels and measured vibration levels are attributable to inaccurate acoustic predictions. These comparisons will also be helpful in assessing whether adjustments to prediction methodologies are needed to improve agreement between the predicted and measured flight data. Future assessment will incorporate hybrid methods in VAOne analysis (i.e., boundary element methods, BEM and finite element methods, FEM). These hybrid methods will enable the ability to import NASTRAN models providing much more detailed modeling of the underlying beams and support structure of the ARES 1-X test vehicle. Measured acoustic data will be incorporated into these analyses to improve correlation for additional post flight analysis.

Clinical tests performed in acute stroke identify the risk of falling during the first year: postural stroke study in Gothenburg (POSTGOT).

PubMed

Persson, Carina U; Hansson, Per-Olof; Sunnerhagen, Katharina S

2011-03-01

To assess the likelihood of clinical tests for postural balance, walking and motor skills, performed during the first week after stroke, identifying the risk of falling. Prospective study. Patients with first stroke. Assessments were carried out during the first week, and the occurrence of falls was recorded 3, 6 and 12 months after stroke onset. The tests used were: 10-Metre Walking Test (10MWT), Timed Up & Go, Swedish Postural Assessment Scale for Stroke Patients, Berg Balance Scale and Modified Motor Assessment Scale. Cut-off levels were obtained by receiver operation characteristic curves, and odds ratios were used to assess cut-off levels for falling. The analyses were based on 96 patients. Forty-eight percent had at least one fall during the first year. All tests were associated with the risk of falling. The highest predictive values were found for the 10MWT (positive predictive value 64%, negative predictive value 76%). Those subjects who were unable to perform the 10MWT had the highest odds ratio, 6.06 (95% confidence interval 2.66-13.84, p<0.001) of falling. Clinical tests used during the first week after stroke onset can, to some extent, identify those patients at risk of falling during the first year after stroke.

Screening of depression in cardiology: A study on 617 cardiovascular patients.

PubMed

Tesio, Valentina; Marra, Sebastiano; Molinaro, Stefania; Torta, Riccardo; Gaita, Fiorenzo; Castelli, Lorys

2017-10-15

Depression screening in the cardiovascular disease (CVD) care setting is under-performed, also because the issue of the optimal screening tools cut-off is still open. We analysed which HADS (Hospital Anxiety and Depression Scale) total score cut-off value shows the best properties in two groups of 357 Acute Coronary Syndrome (ACS) and 260 Chronic Coronary Artery Disease (CAD) hospitalized patients. A Receiver Operating Characteristics (ROC) curve was plotted for both groups using the Montgomery-Asberg Depression Rating Scale (MADRS) as the criterion. Accuracy, positive (PPV) and negative (NPV) predictive values were computed for different cut-off scores. The ROC curves confirmed the excellent/very good accuracy of the HADS in both groups, with an area under the curve of 0.911 for the ACS and 0.893 for the CAD patients. The cut-off of 14 showed the best compromise between high sensitivity and good specificity in both groups, with high negative predicted values (95.5% and 92.4%, respectively). Using a cut-off value of 14, the HADS could be considered a good screening tool to identify hospitalized CAD and ACS patients requiring a more accurate depression assessment, in order to promptly plan the most appropriate treatment strategies and prevent the negative effects of depression in CVD patients. Copyright © 2017 Elsevier B.V. All rights reserved.

Small-for-gestational age and large-for-gestational age thresholds to predict infants at risk of adverse delivery and neonatal outcomes: are current charts adequate? An observational study from the Born in Bradford cohort

PubMed Central

Norris, T; Johnson, W; Farrar, D; Tuffnell, D; Wright, J; Cameron, N

2015-01-01

Objectives Construct an ethnic-specific chart and compare the prediction of adverse outcomes using this chart with the clinically recommended UK-WHO and customised birth weight charts using cut-offs for small-for-gestational age (SGA: birth weight <10th centile) and large-for-gestational age (LGA: birth weight >90th centile). Design Prospective cohort study. Setting Born in Bradford (BiB) study, UK. Participants 3980 White British and 4448 Pakistani infants with complete data for gestational age, birth weight, ethnicity, maternal height, weight and parity. Main outcome measures Prevalence of SGA and LGA, using the three charts and indicators of diagnostic utility (sensitivity, specificity and area under the receiver operating characteristic (AUROC)) of these chart-specific cut-offs to predict delivery and neonatal outcomes and a composite outcome. Results In White British and Pakistani infants, the prevalence of SGA and LGA differed depending on the chart used. Increased risk of SGA was observed when using the UK-WHO and customised charts as opposed to the ethnic-specific chart, while the opposite was apparent when classifying LGA infants. However, the predictive utility of all three charts to identify adverse clinical outcomes was poor, with only the prediction of shoulder dystocia achieving an AUROC>0.62 on all three charts. Conclusions Despite being recommended in national clinical guidelines, the UK-WHO and customised birth weight charts perform poorly at identifying infants at risk of adverse neonatal outcomes. Being small or large may increase the risk of an adverse outcome; however, size alone is not sensitive or specific enough with current detection to be useful. However, a significant amount of missing data for some of the outcomes may have limited the power needed to determine true associations. PMID:25783424

Steady and Unsteady Simulations of the Flow in an Impeller/Diffuser Stage

NASA Technical Reports Server (NTRS)

Canabal, Francisco; Dorney, Daniel J.; Garcia, Roberto; Turner, James E. (Technical Monitor)

2002-01-01

SLI engine designs will require pumps to throttle over a wide flow range while maintaining high performance. Unsteadiness generated by impeller/diffuser interaction is one of the major factors affecting off-design performance. Initial unsteady simulations are completed for impeller/diffuser stage. The Corsair simulations will continue across a wide flow range and for inducer/impeller/diffuser combinations. Results of unsteady simulations are being used to guide and explore new designs.

Design and multifidelity analysis of dual mode scramjet compression system using coupled NPSS and fluent simulation

NASA Astrophysics Data System (ADS)

Vijayakumar, Nandakumar

Hypersonic airbreathing engines mark a potential future development of the aerospace industry and immense efforts have been taken in gaining knowledge in them for the past decades. The physical phenomenon occurring at the hypersonic flow regime makes the design and performance prediction of a scramjet engine hard. Though cutting-edge simulation tools fight their way toward accurate prediction of the environment, the time consumed by the entire process in designing and analyzing a scramjet engine and its component may be exorbitant. A multi-fidelity approach for designing a scramjet with a cruising Mach number of 6 is detailed in this research where high-order simulations are applied according to the physics involved in the component. Two state-of-the-art simulation tools were used to take the aerodynamic and propulsion disciplines into account for realistic prediction of the individual components as well as the entire scramjet. The specific goal of this research is to create a virtual environment to design and analyze a hypersonic, two-dimensional, planar inlet and isolator to check its operability for a dual-mode scramjet engine. The dual mode scramjet engine starts at a Mach number of 3.5 where it operates as a ramjet and accelerates to Mach 6 to be operated as a scramjet engine. The intercomponent interaction between the compression components with the rest of the engine is studied by varying the fidelity of the numerical simulation according to the complexity of the situation. Efforts have been taken to track the transition Mach number as it switches from ramjet to scramjet. A complete scramjet assembly was built using the Numerical Propulsion Simulation System (NPSS) and the performance of the engine was evaluated for various scenarios. Different numerical techniques were opted for varying the fidelity of the analysis with the highest fidelity consisting of 2D RANS CFD simulation. The interaction between the NPSS elements with the CFD solver is governed by the top-level assembly solver of NPSS. The importance of intercomponent interactions are discussed. The methodology used in this research for design and analysis, should add up to provide an efficient way for estimating the design and off-design operating modes of a dual mode scramjet engine.

Sonic boom prediction for the Langley Mach 2 low-boom configuration

NASA Technical Reports Server (NTRS)

Madson, Michael D.

1992-01-01

Sonic boom pressure signatures and aerodynamic force data for the Langley Mach 2 low sonic boom configuration were computed using the TranAir full-potential code. A solution-adaptive Cartesian grid scheme is utilized to compute off-body flow field data. Computations were performed with and without nacelles at several angles of attack. Force and moment data were computed to measure nacelle effects on the aerodynamic characteristics and sonic boom footprints of the model. Pressure signatures were computed both on and off ground-track. Near-field pressure signature computations on ground-track were in good agreement with experimental data. Computed off ground-track signatures showed that maximum pressure peaks were located off ground-track and were significantly higher than the signatures on ground-track. Bow shocks from the nacelle inlets increased lift and drag, and also increased the magnitude of the maximum pressure both on and off ground-track.

Work and excessive sleepiness among Brazilian evening high school students: effects on days off.

PubMed

Teixeira, Liliane; Lowden, Arne; Moreno, Claudia Roberta; Turte, Samantha; Nagai, Roberta; Latorre, Maria Do Rosário; Valente, Daniel; Fischer, Frida Marina

2010-01-01

Previous studies have revealed that students who work and study build up sleep deficits during the workweek, which can trigger a sleep rebound during days off. The objective of this study was to investigate the impact of working/non-working on sleepiness during days off among high school students. The study population, aged 14-21 years, attended evening classes in São Paulo, Brazil. For the study, the students completed questionnaires on living conditions, health, and work; wore actigraphs; and completed the Karolinska Sleepiness Scale (KSS). To predict sleepiness, a logistic regression analysis was performed. Excessive sleepiness was observed on the first day off among working students. Results suggest that working is a significant predictor for sleepiness and that two shifts of daily systematic activities, study and work, might lead to excessive daytime sleepiness on the first day off. Further, this observed excessive sleepiness may reflect the sleep debt accumulated during the workweek.

Real-time Tsunami Inundation Prediction Using High Performance Computers

NASA Astrophysics Data System (ADS)

Oishi, Y.; Imamura, F.; Sugawara, D.

2014-12-01

Recently off-shore tsunami observation stations based on cabled ocean bottom pressure gauges are actively being deployed especially in Japan. These cabled systems are designed to provide real-time tsunami data before tsunamis reach coastlines for disaster mitigation purposes. To receive real benefits of these observations, real-time analysis techniques to make an effective use of these data are necessary. A representative study was made by Tsushima et al. (2009) that proposed a method to provide instant tsunami source prediction based on achieving tsunami waveform data. As time passes, the prediction is improved by using updated waveform data. After a tsunami source is predicted, tsunami waveforms are synthesized from pre-computed tsunami Green functions of linear long wave equations. Tsushima et al. (2014) updated the method by combining the tsunami waveform inversion with an instant inversion of coseismic crustal deformation and improved the prediction accuracy and speed in the early stages. For disaster mitigation purposes, real-time predictions of tsunami inundation are also important. In this study, we discuss the possibility of real-time tsunami inundation predictions, which require faster-than-real-time tsunami inundation simulation in addition to instant tsunami source analysis. Although the computational amount is large to solve non-linear shallow water equations for inundation predictions, it has become executable through the recent developments of high performance computing technologies. We conducted parallel computations of tsunami inundation and achieved 6.0 TFLOPS by using 19,000 CPU cores. We employed a leap-frog finite difference method with nested staggered grids of which resolution range from 405 m to 5 m. The resolution ratio of each nested domain was 1/3. Total number of grid points were 13 million, and the time step was 0.1 seconds. Tsunami sources of 2011 Tohoku-oki earthquake were tested. The inundation prediction up to 2 hours after the earthquake occurs took about 2 minutes, which would be sufficient for a practical tsunami inundation predictions. In the presentation, the computational performance of our faster-than-real-time tsunami inundation model will be shown, and preferable tsunami wave source analysis for an accurate inundation prediction will also be discussed.

Development and Validation of High Precision Thermal, Mechanical, and Optical Models for the Space Interferometry Mission

NASA Technical Reports Server (NTRS)

Lindensmith, Chris A.; Briggs, H. Clark; Beregovski, Yuri; Feria, V. Alfonso; Goullioud, Renaud; Gursel, Yekta; Hahn, Inseob; Kinsella, Gary; Orzewalla, Matthew; Phillips, Charles

2006-01-01

SIM Planetquest (SIM) is a large optical interferometer for making microarcsecond measurements of the positions of stars, and to detect Earth-sized planets around nearby stars. To achieve this precision, SIM requires stability of optical components to tens of picometers per hour. The combination of SIM s large size (9 meter baseline) and the high stability requirement makes it difficult and costly to measure all aspects of system performance on the ground. To reduce risks, costs and to allow for a design with fewer intermediate testing stages, the SIM project is developing an integrated thermal, mechanical and optical modeling process that will allow predictions of the system performance to be made at the required high precision. This modeling process uses commercial, off-the-shelf tools and has been validated against experimental results at the precision of the SIM performance requirements. This paper presents the description of the model development, some of the models, and their validation in the Thermo-Opto-Mechanical (TOM3) testbed which includes full scale brassboard optical components and the metrology to test them at the SIM performance requirement levels.

Free energy landscape for the binding process of Huperzine A to acetylcholinesterase.

PubMed

Bai, Fang; Xu, Yechun; Chen, Jing; Liu, Qiufeng; Gu, Junfeng; Wang, Xicheng; Ma, Jianpeng; Li, Honglin; Onuchic, José N; Jiang, Hualiang

2013-03-12

Drug-target residence time (t = 1/k(off), where k(off) is the dissociation rate constant) has become an important index in discovering better- or best-in-class drugs. However, little effort has been dedicated to developing computational methods that can accurately predict this kinetic parameter or related parameters, k(off) and activation free energy of dissociation (ΔG(off)≠). In this paper, energy landscape theory that has been developed to understand protein folding and function is extended to develop a generally applicable computational framework that is able to construct a complete ligand-target binding free energy landscape. This enables both the binding affinity and the binding kinetics to be accurately estimated. We applied this method to simulate the binding event of the anti-Alzheimer's disease drug (-)-Huperzine A to its target acetylcholinesterase (AChE). The computational results are in excellent agreement with our concurrent experimental measurements. All of the predicted values of binding free energy and activation free energies of association and dissociation deviate from the experimental data only by less than 1 kcal/mol. The method also provides atomic resolution information for the (-)-Huperzine A binding pathway, which may be useful in designing more potent AChE inhibitors. We expect this methodology to be widely applicable to drug discovery and development.

Influence of rainfall and catchment characteristics on urban stormwater quality.

PubMed

Liu, An; Egodawatta, Prasanna; Guan, Yuntao; Goonetilleke, Ashantha

2013-02-01

The accuracy and reliability of urban stormwater quality modelling outcomes are important for stormwater management decision making. The commonly adopted approach where only a limited number of factors are used to predict urban stormwater quality may not adequately represent the complexity of the quality response to a rainfall event or site-to-site differences to support efficient treatment design. This paper discusses an investigation into the influence of rainfall and catchment characteristics on urban stormwater quality in order to investigate the potential areas for errors in current stormwater quality modelling practices. It was found that the influence of rainfall characteristics on pollutant wash-off is step-wise based on specific thresholds. This means that a modelling approach where the wash-off process is predicted as a continuous function of rainfall intensity and duration is not appropriate. Additionally, other than conventional catchment characteristics, namely, land use and impervious surface fraction, other catchment characteristics such as impervious area layout, urban form and site specific characteristics have an important influence on both, pollutant build-up and wash-off processes. Finally, the use of solids as a surrogate to estimate other pollutant species was found to be inappropriate. Individually considering build-up and wash-off processes for each pollutant species should be the preferred option. Copyright © 2012 Elsevier B.V. All rights reserved.

Predicting cardiometabolic disturbances from waist-to-height ratio: findings from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline.

PubMed

Castanheira, Marcelo; Chor, Dóra; Braga, José Uéleres; Cardoso, Letícia de Oliveira; Griep, Rosane Härter; Molina, Maria Del Carmen Bisi; Fonseca, Maria de Jesus Mendes da

2018-04-01

To evaluate the performance of waist-to-height ratio (WHtR) in predicting cardiometabolic outcomes and compare cut-off points for Brazilian adults. Cross-sectional study. WHtR areas under the curve (AUC) were compared with those for BMI, waist circumference (WC) and waist-to-hip ratio (WHR). The outcomes of interest were hypertension, diabetes, hypertriacylglycerolaemia and presence of at least two components of metabolic syndrome (≥2 MetS). Cut-offs for WHtR were compared and validity measures were estimated for each point. Teaching and research institutions in six Brazilian state capitals, 2008-2010. Women (n 5026) and men (n 4238) aged 35-54 years who participated in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) at baseline. WHtR age-adjusted AUC ranged from 0·68 to 0·72 in men and 0·69 to 0·75 in women, with smaller AUC for hypertriacylglycerolaemia and the largest for ≥2 MetS. WHtR performed better than BMI for practically all outcomes; better than WHR for hypertension in both sexes; and displayed larger AUC than WC in predicting diabetes mellitus. It also offered better discriminatory power for ≥2 MetS in men; and was better than WC, but not WHR, in women. Optimal cut-off points of WHtR were 0·55 (women) and 0·54 (men), but they presented high false-negative rate compared with 0·50. We recommend using WHtR (which performed similarly to, or better than, other available indices of adiposity) as an anthropometric index with good discriminatory power for cardiometabolic outcomes in Brazilian adults, indicating the already referenced limit of WHtR≥0·50.

Initial system design method for non-rotationally symmetric systems based on Gaussian brackets and Nodal aberration theory.

PubMed

Zhong, Yi; Gross, Herbert

2017-05-01

Freeform surfaces play important roles in improving the imaging performance of off-axis optical systems. However, for some systems with high requirements in specifications, the structure of the freeform surfaces could be very complicated and the number of freeform surfaces could be large. That brings challenges in fabrication and increases the cost. Therefore, to achieve a good initial system with minimum aberrations and reasonable structure before implementing freeform surfaces is essential for optical designers. The already existing initial system design methods are limited to certain types of systems. A universal tool or method to achieve a good initial system efficiently is very important. In this paper, based on the Nodal aberration theory and the system design method using Gaussian Brackets, the initial system design method is extended from rotationally symmetric systems to general non-rotationally symmetric systems. The design steps are introduced and on this basis, two off-axis three-mirror systems are pre-designed using spherical shape surfaces. The primary aberrations are minimized using the nonlinear least-squares solver. This work provides insight and guidance for initial system design of off-axis mirror systems.

Performance Prediction and Simulation of Gas Turbine Engine Operation (La presision des performances et la simulation du fonctionnement des turbomoteurs)

DTIC Science & Technology

2002-04-01

configuration associated with the HSCT program was analyzed in terms of inlet unstart and the effect of the regurgitated shock wave. Inlet start is a...heavily loaded take off or dog -fight phases of flight. Less critical issues, such as thrust loss during supersonic operations, may also appear. From the

A New Global Regression Analysis Method for the Prediction of Wind Tunnel Model Weight Corrections

NASA Technical Reports Server (NTRS)

Ulbrich, Norbert Manfred; Bridge, Thomas M.; Amaya, Max A.

2014-01-01

A new global regression analysis method is discussed that predicts wind tunnel model weight corrections for strain-gage balance loads during a wind tunnel test. The method determines corrections by combining "wind-on" model attitude measurements with least squares estimates of the model weight and center of gravity coordinates that are obtained from "wind-off" data points. The method treats the least squares fit of the model weight separate from the fit of the center of gravity coordinates. Therefore, it performs two fits of "wind- off" data points and uses the least squares estimator of the model weight as an input for the fit of the center of gravity coordinates. Explicit equations for the least squares estimators of the weight and center of gravity coordinates are derived that simplify the implementation of the method in the data system software of a wind tunnel. In addition, recommendations for sets of "wind-off" data points are made that take typical model support system constraints into account. Explicit equations of the confidence intervals on the model weight and center of gravity coordinates and two different error analyses of the model weight prediction are also discussed in the appendices of the paper.

Object-Oriented Design for Sparse Direct Solvers

NASA Technical Reports Server (NTRS)

Dobrian, Florin; Kumfert, Gary; Pothen, Alex

1999-01-01

We discuss the object-oriented design of a software package for solving sparse, symmetric systems of equations (positive definite and indefinite) by direct methods. At the highest layers, we decouple data structure classes from algorithmic classes for flexibility. We describe the important structural and algorithmic classes in our design, and discuss the trade-offs we made for high performance. The kernels at the lower layers were optimized by hand. Our results show no performance loss from our object-oriented design, while providing flexibility, case of use, and extensibility over solvers using procedural design.

Social dominance explains within-ejaculate variation in sperm design in a passerine bird.

PubMed

Rojas Mora, Alfonso; Meniri, Magali; Ciprietti, Sabrina; Helfenstein, Fabrice

2017-03-04

Comparative studies suggest that sperm competition exerts stabilizing selection towards an optimal sperm design - e.g., the relative size and covariation of different sperm sections or a quantitative measure of sperm shape - that maximizes male fertility, which results in reduced levels of within-male variation in sperm morphology. Yet, these studies also reveal substantial amounts of unexplained within-ejaculate variance, and the factors presiding to the maintenance of such within-male variation in sperm design at the population level still remain to be identified. Sperm competition models predict that males should progressively invest more resources in their germline as their mating costs increase, i.e., the soma/germline allocation trade-off hypothesis. When access to fertile females is determined by social dominance, the soma/germline allocation trade-off hypothesis predicts that dominant males should invest less in the control of spermatogenesis. Hence, dominance should positively correlate with within-male variance in sperm design. In support of this hypothesis, we found that dominant house sparrow males produce ejaculates with higher levels of within-ejaculate variation in sperm design compared to subordinate males. However, after experimentally manipulating male social status, this pattern was not maintained. Our results suggest that males might control variation in sperm design according to their social status to some extent. Yet, it seems that such within-ejaculate variation in sperm design cannot be rapidly adjusted to a new status. While variation in sperm design could result from various non-exclusive sources, we discuss how strategic allocation of resources to the somatic vs. the germline functions could be an important process shaping the relationship between within-male variation in sperm design and social status.

The effects of klapskate hinge position on push-off performance: a simulation study.

PubMed

Houdijk, Han; Bobbert, Maarten F; De Koning, Jos J; De Groot, Gert

2003-12-01

The introduction of the klapskate in speed skating confronts skaters with the question of how to adjust the position of the hinge in order to maximize performance. The purpose of this study was to reveal the constraint that klapskate hinge position imposes on push-off performance in speed skating. For this purpose, a model of the musculoskeletal system was designed to simulate a simplified, two-dimensional skating push off. To capture the essence of a skating push off, this model performed a one-leg vertical jump, from a frictionless surface, while keeping its trunk horizontally. In this model, klapskate hinge position was varied by varying the length of the foot segment between 115 and 300 mm. With each foot length, an optimal control solution was found that resulted in the maximal amount of vertical kinetic and potential energy of the body's center of mass at take off (Weff). Foot length was shown to considerably affect push-off performance. Maximal Weff was obtained with a foot length of 185 mm and decreased by approximately 25% at either foot length of 115 mm and 300 mm. The reason for this decrease was that foot length affected the onset and control of foot rotation. This resulted in a distortion of the pattern of leg segment rotations and affected muscle work (Wmus) and the efficacy ratio (Weff/Wmus) of the entire leg system. Despite its simplicity, the model very well described and explained the effects of klapskate hinge position on push off performance that have been observed in speed-skating experiments. The simplicity of the model, however, does not allow quantitative analyses of optimal klapskate hinge position for speed-skating practice.

Quantifying design trade-offs of beryllium targets on NIF

NASA Astrophysics Data System (ADS)

Yi, S. A.; Zylstra, A. B.; Kline, J. L.; Loomis, E. N.; Kyrala, G. A.; Shah, R. C.; Perry, T. S.; Kanzleiter, R. J.; Batha, S. H.; MacLaren, S. A.; Ralph, J. E.; Masse, L. P.; Salmonson, J. D.; Tipton, R. E.; Callahan, D. A.; Hurricane, O. A.

2017-10-01

An important determinant of target performance is implosion kinetic energy, which scales with the capsule size. The maximum achievable performance for a given laser is thus related to the largest capsule that can be imploded symmetrically, constrained by drive uniformity. A limiting factor for symmetric radiation drive is the ratio of hohlraum to capsule radii, or case-to-capsule ratio (CCR). For a fixed laser energy, a larger hohlraum allows for driving bigger capsules symmetrically at the cost of reduced peak radiation temperature (Tr). Beryllium ablators may thus allow for unique target design trade-offs due to their higher ablation efficiency at lower Tr. By utilizing larger hohlraum sizes than most modern NIF designs, beryllium capsules thus have the potential to operate in unique regions of the target design parameter space. We present design simulations of beryllium targets with a large CCR = 4.3 3.7 . These are scaled surrogates of large hohlraum low Tr beryllium targets, with the goal of quantifying symmetry tunability as a function of CCR. This work performed under the auspices of the U.S. DOE by LANL under contract DE-AC52- 06NA25396, and by LLNL under Contract DE-AC52-07NA27344.

Design of a Kaplan turbine for a wide range of operating head -Curved draft tube design and model test verification-

NASA Astrophysics Data System (ADS)

KO, Pohan; MATSUMOTO, Kiyoshi; OHTAKE, Norio; DING, Hua

2016-11-01

As for turbomachine off-design performance improvement is challenging but critical for maximising the performing area. In this paper, a curved draft tube for a medium head Kaplan type hydro turbine is introduced and discussed for its significant effect on expanding operating head range. Without adding any extra structure and working fluid for swirl destruction and damping, a carefully designed outline shape of draft tube with the selected placement of center-piers successfully supresses the growth of turbulence eddy and the transport of the swirl to the outlet. Also, more kinetic energy is recovered and the head lost is improved. Finally, the model test results are also presented. The obvious performance improvement was found in the lower net head area, where the maximum efficiency improvement was measured up to 20% without compromising the best efficiency point. Additionally, this design results in a new draft tube more compact in size and so leads to better construction and manufacturing cost performance for prototype. The draft tube geometry parameter designing process was concerning the best efficiency point together with the off-design points covering various water net heads and discharges. The hydraulic performance and flow behavior was numerically previewed and visualized by solving Reynolds-Averaged Navier-Stokes equations with Shear Stress Transport turbulence model. The simulation was under the assumption of steady-state incompressible turbulence flow inside the flow passage, and the inlet boundary condition was the carefully simulated flow pattern from the runner outlet. For confirmation, the corresponding turbine efficiency performance of the entire operating area was verified by model test.

Early Detection of Heart Failure Using Electronic Health Records: Practical Implications for Time Before Diagnosis, Data Diversity, Data Quantity, and Data Density.

PubMed

Ng, Kenney; Steinhubl, Steven R; deFilippi, Christopher; Dey, Sanjoy; Stewart, Walter F

2016-11-01

Using electronic health records data to predict events and onset of diseases is increasingly common. Relatively little is known, although, about the tradeoffs between data requirements and model utility. We examined the performance of machine learning models trained to detect prediagnostic heart failure in primary care patients using longitudinal electronic health records data. Model performance was assessed in relation to data requirements defined by the prediction window length (time before clinical diagnosis), the observation window length (duration of observation before prediction window), the number of different data domains (data diversity), the number of patient records in the training data set (data quantity), and the density of patient encounters (data density). A total of 1684 incident heart failure cases and 13 525 sex, age-category, and clinic matched controls were used for modeling. Model performance improved as (1) the prediction window length decreases, especially when <2 years; (2) the observation window length increases but then levels off after 2 years; (3) the training data set size increases but then levels off after 4000 patients; (4) more diverse data types are used, but, in order, the combination of diagnosis, medication order, and hospitalization data was most important; and (5) data were confined to patients who had ≥10 phone or face-to-face encounters in 2 years. These empirical findings suggest possible guidelines for the minimum amount and type of data needed to train effective disease onset predictive models using longitudinal electronic health records data. © 2016 American Heart Association, Inc.

Sparse interferometric millimeter-wave array for centimeter-level 100-m standoff imaging

NASA Astrophysics Data System (ADS)

Suen, Jonathan Y.; Lubin, Philip M.; Solomon, Steven L.; Ginn, Robert P.

2013-05-01

We present work on the development of a long range standoff concealed weapons detection system capable of imaging under very heavy clothing at distances exceeding 100 m with a cm resolution. The system is based off a combination of phased array technologies used in radio astronomy and SAR radar by using a coherent, multi-frequency reconstruction algorithm which can run at up to 1000 Hz frame rates and high SNR with a multi-tone transceiver. We show the flexible design space of our system as well as algorithm development, predicted system performance and impairments, and simulated reconstructed images. The system can be used for a variety of purposes including portal applications, crowd scanning and tactical situations. Additional uses include seeing through dust and fog.

Changes in corticospinal excitability during consolidation predict acute exercise-induced off-line gains in procedural memory.

PubMed

Ostadan, Fatemeh; Centeno, Carla; Daloze, Jean-Felix; Frenn, Mira; Lundbye-Jensen, Jesper; Roig, Marc

2016-12-01

A single bout of cardiovascular exercise performed immediately after practicing a motor task improves the long-term retention of the skill through an optimization of memory consolidation. However, the specific brain mechanisms underlying the effects of acute cardiovascular exercise on procedural memory are poorly understood. We sought to determine if a single bout of exercise modifies corticospinal excitability (CSE) during the early stages of memory consolidation. In addition, we investigated if changes in CSE are associated with exercise-induced off-line gains in procedural memory. Participants practiced a serial reaction time task followed by either a short bout of acute exercise or a similar rest period. To monitor changes in CSE we used transcranial magnetic stimulation applied to the primary motor cortex (M1) at baseline, 15, 35, 65 and 125min after exercise or rest. Participants in the exercise condition showed larger (∼24%) improvements in procedural memory through consolidation although differences between groups did not reach statistical significance. Exercise promoted an increase in CSE, which remained elevated 2h after exercise. More importantly, global increases in CSE following exercise correlated with the magnitude of off-line gains in skill level assessed in a retention test performed 8h after motor practice. A single bout of exercise modulates short-term neuroplasticity mechanisms subserving consolidation processes that predict off-line gains in procedural memory. Copyright © 2016 Elsevier Inc. All rights reserved.

Analysis and design of planar and non-planar wings for induced drag minimization

NASA Technical Reports Server (NTRS)

Mortara, Karl W.; Straussfogel, Dennis M.; Maughmer, Mark D.

1992-01-01

The goal of the work reported herein is to develop and validate computational tools to be used for the design of planar and non-planar wing geometries for minimum induced drag. Because of the iterative nature of the design problem, it is important that, in addition to being sufficiently accurate for the problem at hand, these tools need to be reasonably fast and computationally efficient. Toward this end, a method of predicting induced drag in the presence of a free wake has been coupled with a panel method. The induced drag prediction technique is based on the application of the Kutta-Joukowski law at the trailing edge. Until now, the use of this method has not been fully explored and pressure integration and Trefftz-plane calculations favored. As is shown in this report, however, the Kutta-Joukowski method is able to give better results for a given amount of effort than the more commonly used techniques, particularly when relaxed wakes and non-planar wing geometries are considered. Using these methods, it is demonstrated that a reduction in induced drag can be achieved through non-planar wing geometries. It remains to determine what overall drag reductions are possible when the induced drag reduction is traded-off against increased wetted area. With the design methodology that is described herein, such trade studies can be performed in which the non-linear effects of the free wake are taken into account.

Theoretical Tools and Software for Modeling, Simulation and Control Design of Rocket Test Facilities

NASA Technical Reports Server (NTRS)

Richter, Hanz

2004-01-01

A rocket test stand and associated subsystems are complex devices whose operation requires that certain preparatory calculations be carried out before a test. In addition, real-time control calculations must be performed during the test, and further calculations are carried out after a test is completed. The latter may be required in order to evaluate if a particular test conformed to specifications. These calculations are used to set valve positions, pressure setpoints, control gains and other operating parameters so that a desired system behavior is obtained and the test can be successfully carried out. Currently, calculations are made in an ad-hoc fashion and involve trial-and-error procedures that may involve activating the system with the sole purpose of finding the correct parameter settings. The goals of this project are to develop mathematical models, control methodologies and associated simulation environments to provide a systematic and comprehensive prediction and real-time control capability. The models and controller designs are expected to be useful in two respects: 1) As a design tool, a model is the only way to determine the effects of design choices without building a prototype, which is, in the context of rocket test stands, impracticable; 2) As a prediction and tuning tool, a good model allows to set system parameters off-line, so that the expected system response conforms to specifications. This includes the setting of physical parameters, such as valve positions, and the configuration and tuning of any feedback controllers in the loop.

The performance characteristics of prostate-specific antigen and prostate-specific antigen density in Chinese men.

PubMed

Teoh, Jeremy Yc; Yuen, Steffi Kk; Tsu, James Hl; Wong, Charles Kw; Ho, Brian Sh; Ng, Ada Tl; Ma, Wai-Kit; Ho, Kwan-Lun; Yiu, Ming-Kwong

2017-01-01

We investigated the performance characteristics of prostate-specific antigen (PSA) and PSA density (PSAD) in Chinese men. All Chinese men who underwent transrectal ultrasound-guided prostate biopsy (TRUS-PB) from year 2000 to 2013 were included. The receiver operating characteristic (ROC) curves for both PSA and PSAD were analyzed. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) at different cut-off levels were calculated. A total of 2606 Chinese men were included. For the ROC, the area under curve was 0.770 for PSA (P < 0.001) and 0.823 for PSAD (P < 0.001). PSA of 4.5 ng ml-1 had sensitivity of 94.4%, specificity of 14.1%, PPV of 29.5%, and NPV of 86.9%; PSAD of 0.12 ng ml-1 cc-1 had sensitivity of 94.5%, specificity of 26.6%, PPV of 32.8%, and NPV of 92.7%. On multivariate logistic regression analyses, PSA cut-off at 4.5 ng ml-1 (OR 1.61, 95% CI 1.05-2.45, P= 0.029) and PSAD cut-off at 0.12 ng ml-1 cc-1 (OR 6.22, 95% CI 4.20-9.22, P< 0.001) were significant predictors for prostate cancer detection on TRUS-PB. In conclusion, the performances of PSA and PSAD at different cut-off levels in Chinese men were very different from those in Caucasians. PSA of 4.5 ng ml-1 and PSAD of 0.12 ng ml-1 cc-1 had near 95% sensitivity and were significant predictors of prostate cancer detection in Chinese men.

Optimal BMI Cut-off Points for Prediction of Incident Diabetes in Chinese population.

PubMed

Ma, Hao; Wu, Xiaoyan; Guo, Xiaoyu; Yang, Jianjun; Ma, Xiaohui; Lv, Mengfan; Li, Ying

2018-05-26

The current BMI classifications have been established based on risk of obesity-related conditions, but not specifically on type 2 diabetes mellitus (T2DM). This study aimed to identify the optimal BMI cutoffs for assessing incident T2DM risk in Chinese population. The longitudinal study cohort consisted of 8,735 non-diabetic participants aged 20-74 years at baseline, with a mean follow-up period of 6.0 years. Body mass index (BMI), 2-h glucose of 75-g oral glucose tolerance test, and glycosylated hemoglobin were measured at baseline and follow-up survey. During the follow-up period, 825 participants were diagnosed with T2DM. In multivariable Cox regression analyses, adjusting for covariates, a strong positive association between BMI and incident T2DM was found among whole population, when stratified by age groups (20-39 years, 40-59 years, 60-74 years), the risk associations between BMI and incident T2DM decreased with increasing age-specific groups, and extinguished in the 60-74 age group (P-value of interaction<0.001). The optimal BMI cut-offs (kg/m 2 ) for predicting T2DM risk for men and women were 25.5 and 24.4 in the 20-39 age group, and 23.5 and 23.0 in the 40-59 age group, respectively. But no predictive performance was observed in the 60-74 age group in both sexes. Our results suggested that the performance of BMI in predicting T2DM risk was the best in younger age and decreased with age. Age- and sex-specific BMI cut-offs should be considered for T2DM risk stratification in Chinese population. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Simulating flame lift-off characteristics of diesel and biodiesel fuels using detailed chemical-kinetic mechanisms and LES turbulence model.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Som, S; Longman, D. E.; Luo, Z

2012-01-01

Combustion in direct-injection diesel engines occurs in a lifted, turbulent diffusion flame mode. Numerous studies indicate that the combustion and emissions in such engines are strongly influenced by the lifted flame characteristics, which are in turn determined by fuel and air mixing in the upstream region of the lifted flame, and consequently by the liquid breakup and spray development processes. From a numerical standpoint, these spray combustion processes depend heavily on the choice of underlying spray, combustion, and turbulence models. The present numerical study investigates the influence of different chemical kinetic mechanisms for diesel and biodiesel fuels, as well asmore » Reynolds-averaged Navier-Stokes (RANS) and large eddy simulation (LES) turbulence models on predicting flame lift-off lengths (LOLs) and ignition delays. Specifically, two chemical kinetic mechanisms for n-heptane (NHPT) and three for biodiesel surrogates are investigated. In addition, the RNG k-{epsilon} (RANS) model is compared to the Smagorinsky based LES turbulence model. Using adaptive grid resolution, minimum grid sizes of 250 {micro}m and 125 {micro}m were obtained for the RANS and LES cases respectively. Validations of these models were performed against experimental data from Sandia National Laboratories in a constant volume combustion chamber. Ignition delay and flame lift-off validations were performed at different ambient temperature conditions. The LES model predicts lower ignition delays and qualitatively better flame structures compared to the RNG k-{epsilon} model. The use of realistic chemistry and a ternary surrogate mixture, which consists of methyl decanoate, methyl 9-decenoate, and NHPT, results in better predicted LOLs and ignition delays. For diesel fuel though, only marginal improvements are observed by using larger size mechanisms. However, these improved predictions come at a significant increase in computational cost.« less

Design Characteristics Influence Performance of Clinical Prediction Rules in Validation: A Meta-Epidemiological Study

PubMed Central

Ban, Jong-Wook; Emparanza, José Ignacio; Urreta, Iratxe; Burls, Amanda

2016-01-01

Background Many new clinical prediction rules are derived and validated. But the design and reporting quality of clinical prediction research has been less than optimal. We aimed to assess whether design characteristics of validation studies were associated with the overestimation of clinical prediction rules’ performance. We also aimed to evaluate whether validation studies clearly reported important methodological characteristics. Methods Electronic databases were searched for systematic reviews of clinical prediction rule studies published between 2006 and 2010. Data were extracted from the eligible validation studies included in the systematic reviews. A meta-analytic meta-epidemiological approach was used to assess the influence of design characteristics on predictive performance. From each validation study, it was assessed whether 7 design and 7 reporting characteristics were properly described. Results A total of 287 validation studies of clinical prediction rule were collected from 15 systematic reviews (31 meta-analyses). Validation studies using case-control design produced a summary diagnostic odds ratio (DOR) 2.2 times (95% CI: 1.2–4.3) larger than validation studies using cohort design and unclear design. When differential verification was used, the summary DOR was overestimated by twofold (95% CI: 1.2 -3.1) compared to complete, partial and unclear verification. The summary RDOR of validation studies with inadequate sample size was 1.9 (95% CI: 1.2 -3.1) compared to studies with adequate sample size. Study site, reliability, and clinical prediction rule was adequately described in 10.1%, 9.4%, and 7.0% of validation studies respectively. Conclusion Validation studies with design shortcomings may overestimate the performance of clinical prediction rules. The quality of reporting among studies validating clinical prediction rules needs to be improved. PMID:26730980

Design Characteristics Influence Performance of Clinical Prediction Rules in Validation: A Meta-Epidemiological Study.

PubMed

Ban, Jong-Wook; Emparanza, José Ignacio; Urreta, Iratxe; Burls, Amanda

2016-01-01

Many new clinical prediction rules are derived and validated. But the design and reporting quality of clinical prediction research has been less than optimal. We aimed to assess whether design characteristics of validation studies were associated with the overestimation of clinical prediction rules' performance. We also aimed to evaluate whether validation studies clearly reported important methodological characteristics. Electronic databases were searched for systematic reviews of clinical prediction rule studies published between 2006 and 2010. Data were extracted from the eligible validation studies included in the systematic reviews. A meta-analytic meta-epidemiological approach was used to assess the influence of design characteristics on predictive performance. From each validation study, it was assessed whether 7 design and 7 reporting characteristics were properly described. A total of 287 validation studies of clinical prediction rule were collected from 15 systematic reviews (31 meta-analyses). Validation studies using case-control design produced a summary diagnostic odds ratio (DOR) 2.2 times (95% CI: 1.2-4.3) larger than validation studies using cohort design and unclear design. When differential verification was used, the summary DOR was overestimated by twofold (95% CI: 1.2 -3.1) compared to complete, partial and unclear verification. The summary RDOR of validation studies with inadequate sample size was 1.9 (95% CI: 1.2 -3.1) compared to studies with adequate sample size. Study site, reliability, and clinical prediction rule was adequately described in 10.1%, 9.4%, and 7.0% of validation studies respectively. Validation studies with design shortcomings may overestimate the performance of clinical prediction rules. The quality of reporting among studies validating clinical prediction rules needs to be improved.

Solid rocket booster performance evaluation model. Volume 1: Engineering description

NASA Technical Reports Server (NTRS)

1974-01-01

The space shuttle solid rocket booster performance evaluation model (SRB-II) is made up of analytical and functional simulation techniques linked together so that a single pass through the model will predict the performance of the propulsion elements of a space shuttle solid rocket booster. The available options allow the user to predict static test performance, predict nominal and off nominal flight performance, and reconstruct actual flight and static test performance. Options selected by the user are dependent on the data available. These can include data derived from theoretical analysis, small scale motor test data, large motor test data and motor configuration data. The user has several options for output format that include print, cards, tape and plots. Output includes all major performance parameters (Isp, thrust, flowrate, mass accounting and operating pressures) as a function of time as well as calculated single point performance data. The engineering description of SRB-II discusses the engineering and programming fundamentals used, the function of each module, and the limitations of each module.

Role of pharmacogenetics on deferasirox AUC and efficacy.

PubMed

Cusato, Jessica; Allegra, Sarah; De Francia, Silvia; Massano, Davide; Piga, Antonio; D'Avolio, Antonio

2016-04-01

We evaluated deferasirox pharmacokinetic according to SNPs in genes involved in its metabolism and elimination. Moreover, we defined a plasma area under the curve cut-off value predicting therapy response. Allelic discrimination was performed by real-time PCR. Drug plasma concentrations were measured by a high performance liquid chromatography system coupled with an ultraviolet method. Pharmacokinetic parameters were significantly influenced by UGT1A1 rs887829C>T, UGT1A3 rs1983023C>T and rs3806596A>G SNPs. Area under the curve cut-off values of 360 μg/ml/h for efficacy were here defined and 250 μg/ml/h for nonresponse was reported. UGT1A3 rs3806596GG and ABCG2 rs13120400CC genotypes were factors able to predict efficacy, whereas UGT1A3 rs3806596GG was a nonresponse predictor. These data show how screening patient's genetic profile may help clinicians to optimize iron chelation therapy with deferasirox.

Constant versus variable response signal delays in speed--accuracy trade-offs: effects of advance preparation for processing time.

PubMed

Miller, Jeff; Sproesser, Gudrun; Ulrich, Rolf

2008-07-01

In two experiments, we used response signals (RSs) to control processing time and trace out speed--accuracy trade-off(SAT) functions in a difficult perceptual discrimination task. Each experiment compared performance in blocks of trials with constant and, hence, temporally predictable RS lags against performance in blocks with variable, unpredictable RS lags. In both experiments, essentially equivalent SAT functions were observed with constant and variable RS lags. We conclude that there is little effect of advance preparation for a given processing time, suggesting that the discrimination mechanisms underlying SAT functions are driven solely by bottom-up information processing in perceptual discrimination tasks.

Effect of experimental design on the prediction performance of calibration models based on near-infrared spectroscopy for pharmaceutical applications.

PubMed

Bondi, Robert W; Igne, Benoît; Drennen, James K; Anderson, Carl A

2012-12-01

Near-infrared spectroscopy (NIRS) is a valuable tool in the pharmaceutical industry, presenting opportunities for online analyses to achieve real-time assessment of intermediates and finished dosage forms. The purpose of this work was to investigate the effect of experimental designs on prediction performance of quantitative models based on NIRS using a five-component formulation as a model system. The following experimental designs were evaluated: five-level, full factorial (5-L FF); three-level, full factorial (3-L FF); central composite; I-optimal; and D-optimal. The factors for all designs were acetaminophen content and the ratio of microcrystalline cellulose to lactose monohydrate. Other constituents included croscarmellose sodium and magnesium stearate (content remained constant). Partial least squares-based models were generated using data from individual experimental designs that related acetaminophen content to spectral data. The effect of each experimental design was evaluated by determining the statistical significance of the difference in bias and standard error of the prediction for that model's prediction performance. The calibration model derived from the I-optimal design had similar prediction performance as did the model derived from the 5-L FF design, despite containing 16 fewer design points. It also outperformed all other models estimated from designs with similar or fewer numbers of samples. This suggested that experimental-design selection for calibration-model development is critical, and optimum performance can be achieved with efficient experimental designs (i.e., optimal designs).

Structural Probing of Off-Target G Protein-Coupled Receptor Activities within a Series of Adenosine/Adenine Congeners

PubMed Central

Paoletta, Silvia; Tosh, Dilip K.; Salvemini, Daniela; Jacobson, Kenneth A.

2014-01-01

We studied patterns of off-target receptor interactions, mostly at G protein-coupled receptors (GPCRs) in the µM range, of nucleoside derivatives that are highly engineered for nM interaction with adenosine receptors (ARs). Because of the considerable interest of using AR ligands for treating diseases of the CNS, we used the Psychoactive Drug Screening Program (PDSP) for probing promiscuity of these adenosine/adenine congeners at 41 diverse receptors, channels and a transporter. The step-wise truncation of rigidified, trisubstituted (at N6, C2, and 5′ positions) nucleosides revealed unanticipated interactions mainly with biogenic amine receptors, such as adrenergic receptors and serotonergic receptors, with affinities as high as 61 nM. The unmasking of consistent sets of structure activity relationship (SAR) at novel sites suggested similarities between receptor families in molecular recognition. Extensive molecular modeling of the GPCRs affected suggested binding modes of the ligands that supported the patterns of SAR at individual receptors. In some cases, the ligand docking mode closely resembled AR binding and in other cases the ligand assumed different orientations. The recognition patterns for different GPCRs were clustered according to which substituent groups were tolerated and explained in light of the complementarity with the receptor binding site. Thus, some likely off-target interactions, a concern for secondary drug effects, can be predicted for analogues of this set of substructures, aiding the design of additional structural analogues that either eliminate or accentuate certain off-target activities. Moreover, similar analyses could be performed for unrelated structural families for other GPCRs. PMID:24859150

Structural probing of off-target G protein-coupled receptor activities within a series of adenosine/adenine congeners.

PubMed

Paoletta, Silvia; Tosh, Dilip K; Salvemini, Daniela; Jacobson, Kenneth A

2014-01-01

We studied patterns of off-target receptor interactions, mostly at G protein-coupled receptors (GPCRs) in the µM range, of nucleoside derivatives that are highly engineered for nM interaction with adenosine receptors (ARs). Because of the considerable interest of using AR ligands for treating diseases of the CNS, we used the Psychoactive Drug Screening Program (PDSP) for probing promiscuity of these adenosine/adenine congeners at 41 diverse receptors, channels and a transporter. The step-wise truncation of rigidified, trisubstituted (at N6, C2, and 5' positions) nucleosides revealed unanticipated interactions mainly with biogenic amine receptors, such as adrenergic receptors and serotonergic receptors, with affinities as high as 61 nM. The unmasking of consistent sets of structure activity relationship (SAR) at novel sites suggested similarities between receptor families in molecular recognition. Extensive molecular modeling of the GPCRs affected suggested binding modes of the ligands that supported the patterns of SAR at individual receptors. In some cases, the ligand docking mode closely resembled AR binding and in other cases the ligand assumed different orientations. The recognition patterns for different GPCRs were clustered according to which substituent groups were tolerated and explained in light of the complementarity with the receptor binding site. Thus, some likely off-target interactions, a concern for secondary drug effects, can be predicted for analogues of this set of substructures, aiding the design of additional structural analogues that either eliminate or accentuate certain off-target activities. Moreover, similar analyses could be performed for unrelated structural families for other GPCRs.

Assessing trade-offs in large marine protected areas.

PubMed

Davies, Tammy E; Epstein, Graham; Aguilera, Stacy E; Brooks, Cassandra M; Cox, Michael; Evans, Louisa S; Maxwell, Sara M; Nenadovic, Mateja; Ban, Natalie C

2018-01-01

Large marine protected areas (LMPAs) are increasingly being established and have a high profile in marine conservation. LMPAs are expected to achieve multiple objectives, and because of their size are postulated to avoid trade-offs that are common in smaller MPAs. However, evaluations across multiple outcomes are lacking. We used a systematic approach to code several social and ecological outcomes of 12 LMPAs. We found evidence of three types of trade-offs: trade-offs between different ecological resources (supply trade-offs); trade-offs between ecological resource conditions and the well-being of resource users (supply-demand trade-offs); and trade-offs between the well-being outcomes of different resource users (demand trade-offs). We also found several divergent outcomes that were attributed to influences beyond the scope of the LMPA. We suggest that despite their size, trade-offs can develop in LMPAs and should be considered in planning and design. LMPAs may improve their performance across multiple social and ecological objectives if integrated with larger-scale conservation efforts.

Assessing trade-offs in large marine protected areas

PubMed Central

Aguilera, Stacy E.; Brooks, Cassandra M.; Cox, Michael; Evans, Louisa S.; Maxwell, Sara M.; Nenadovic, Mateja

2018-01-01

Large marine protected areas (LMPAs) are increasingly being established and have a high profile in marine conservation. LMPAs are expected to achieve multiple objectives, and because of their size are postulated to avoid trade-offs that are common in smaller MPAs. However, evaluations across multiple outcomes are lacking. We used a systematic approach to code several social and ecological outcomes of 12 LMPAs. We found evidence of three types of trade-offs: trade-offs between different ecological resources (supply trade-offs); trade-offs between ecological resource conditions and the well-being of resource users (supply-demand trade-offs); and trade-offs between the well-being outcomes of different resource users (demand trade-offs). We also found several divergent outcomes that were attributed to influences beyond the scope of the LMPA. We suggest that despite their size, trade-offs can develop in LMPAs and should be considered in planning and design. LMPAs may improve their performance across multiple social and ecological objectives if integrated with larger-scale conservation efforts. PMID:29668750

A levels and intelligence as predictors of medical careers in UK doctors: 20 year prospective study

PubMed Central

McManus, I C; Smithers, Eleni; Partridge, Philippa; Keeling, A; Fleming, Peter R

2003-01-01

Objective To assess whether A level grades (achievement) and intelligence (ability) predict doctors' careers. Design Prospective cohort study with follow up after 20 years by postal questionnaire. Setting A UK medical school in London. Participants 511 doctors who had entered Westminster Medical School as clinical students between 1975 and 1982 were followed up in January 2002. Main outcome measures Time taken to reach different career grades in hospital or general practice, postgraduate qualifications obtained (membership/fellowships, diplomas, higher academic degrees), number of research publications, and measures of stress and burnout related to A level grades and intelligence (result of AH5 intelligence test) at entry to clinical school. General health questionnaire, Maslach burnout inventory, and questionnaire on satisfaction with career at follow up. Results 47 (9%) doctors were no longer on the Medical Register. They had lower A level grades than those who were still on the register (P < 0.001). A levels also predicted performance in undergraduate training, performance in postregistration house officer posts, and time to achieve membership qualifications (Cox regression, P < 0.001; b=0.376, SE=0.098, exp(b)=1.457). Intelligence did not independently predict dropping off the register, career outcome, or other measures. A levels did not predict diploma or higher academic qualifications, research publications, or stress or burnout. Diplomas, higher academic degrees, and research publications did, however, significantly correlate with personality measures. Conclusions Results of achievement tests, in this case A level grades, which are particularly used for selection of students in the United Kingdom, have long term predictive validity for undergraduate and postgraduate careers. In contrast, a test of ability or aptitude (AH5) was of little predictive validity for subsequent medical careers. PMID:12869457

Integration of preclinical and clinical knowledge to predict intravenous PK in human: bilastine case study.

PubMed

Vozmediano, Valvanera; Ortega, Ignacio; Lukas, John C; Gonzalo, Ana; Rodriguez, Monica; Lucero, Maria Luisa

2014-03-01

Modern pharmacometrics can integrate and leverage all prior proprietary and public knowledge. Such methods can be used to scale across species or comparators, perform clinical trial simulation across alternative designs, confirm hypothesis and potentially reduce development burden, time and costs. Crucial yet typically lacking in integration is the pre-clinical stage. Prediction of PK in man, using in vitro and in vivo studies in different animal species, is increasingly well theorized but could still find wider application in drug development. The aim of the present work was to explore methods for bridging pharmacokinetic knowledge from animal species (i.v. and p.o.) and man (p.o.) into i.v. in man using the antihistamine drug bilastine as example. A model, predictive of i.v. PK in man, was developed on data from two pre-clinical species (rat and dog) and p.o. in man bilastine trials performed earlier. In the knowledge application stage, two different approaches were used to predict human plasma concentration after i.v. of bilastine: allometry (several scaling methods) and a semi-physiological method. Both approaches led to successful predictions of key i.v. PK parameters of bilastine in man. The predictive i.v. PK model was validated using later data from a clinical study of i.v. bilastine. Introduction of such knowledge in development permits proper leveraging of all emergent knowledge as well as quantification-based exploration of PK scenario, e.g. in special populations (pediatrics, renal insufficiency, comedication). In addition, the methods permit reduction or elimination and certainly optimization of learning trials, particularly those concerning alternative off-label administration routes.

Reusability of EMR Data for Applying Cubbin and Jackson Pressure Ulcer Risk Assessment Scale in Critical Care Patients

PubMed Central

Kim, Eunkyung; Lee, JuHee; Kim, Young Ah

2013-01-01

Objectives The purposes of this study were to examine the predictive validity of the Cubbin and Jackson pressure ulcer risk assessment scale for the development of pressure ulcers in intensive care unit (ICU) patients retrospectively and to evaluate the reusability of Electronic Medical Records (EMR) data. Methods A retrospective design was used to examine 829 cases admitted to four ICUs in a tertiary care hospital from May 2010 to April 2011. Patients who were without pressure ulcers at admission to ICU, 18 years or older, and had stayed in ICU for 24 hours or longer were included. Sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve (AUC) were calculated. Results The reported incidence rate of pressure ulcers among the study subjects was 14.2%. At the cut-off score of 24 of the Cubbin and Jackson scale, the sensitivity, specificity, positive predictive value, negative predictive value, and AUC were 72.0%, 68.8%, 27.7%, 93.7%, and 0.76, respectively. Eight items out 10 of the Cubbin and Jackson scale were readily available in the EMR data. Conclusions The Cubbin and Jackson scale performed slightly better than the Braden scale to predict pressure ulcer development. Eight items of the Cubbin and Jackson scale except mobility and hygiene can be extracted from the EMR, which initially demonstrated the reusability of EMR data for pressure ulcer risk assessment. If the Cubbin and Jackson scale is a part of the EMR assessment form, it would help nurses perform tasks to effectively prevent pressure ulcers with an EMR alert for high-risk patients. PMID:24523990

Application of multivariate Gaussian detection theory to known non-Gaussian probability density functions

NASA Astrophysics Data System (ADS)

Schwartz, Craig R.; Thelen, Brian J.; Kenton, Arthur C.

1995-06-01

A statistical parametric multispectral sensor performance model was developed by ERIM to support mine field detection studies, multispectral sensor design/performance trade-off studies, and target detection algorithm development. The model assumes target detection algorithms and their performance models which are based on data assumed to obey multivariate Gaussian probability distribution functions (PDFs). The applicability of these algorithms and performance models can be generalized to data having non-Gaussian PDFs through the use of transforms which convert non-Gaussian data to Gaussian (or near-Gaussian) data. An example of one such transform is the Box-Cox power law transform. In practice, such a transform can be applied to non-Gaussian data prior to the introduction of a detection algorithm that is formally based on the assumption of multivariate Gaussian data. This paper presents an extension of these techniques to the case where the joint multivariate probability density function of the non-Gaussian input data is known, and where the joint estimate of the multivariate Gaussian statistics, under the Box-Cox transform, is desired. The jointly estimated multivariate Gaussian statistics can then be used to predict the performance of a target detection algorithm which has an associated Gaussian performance model.

Cavitating Propeller Performance in Inclined Shaft Conditions with OpenFOAM: PPTC 2015 Test Case

NASA Astrophysics Data System (ADS)

Gaggero, Stefano; Villa, Diego

2018-05-01

In this paper, we present our analysis of the non-cavitating and cavitating unsteady performances of the Potsdam Propeller Test Case (PPTC) in oblique flow. For our calculations, we used the Reynolds-averaged Navier-Stokes equation (RANSE) solver from the open-source OpenFOAM libraries. We selected the homogeneous mixture approach to solve for multiphase flow with phase change, using the volume of fluid (VoF) approach to solve the multiphase flow and modeling the mass transfer between vapor and water with the Schnerr-Sauer model. Comparing the model results with the experimental measurements collected during the Second Workshop on Cavitation and Propeller Performance - SMP'15 enabled our assessment of the reliability of the open-source calculations. Comparisons with the numerical data collected during the workshop enabled further analysis of the reliability of different flow solvers from which we produced an overview of recommended guidelines (mesh arrangements and solver setups) for accurate numerical prediction even in off-design conditions. Lastly, we propose a number of calculations using the boundary element method developed at the University of Genoa for assessing the reliability of this dated but still widely adopted approach for design and optimization in the preliminary stages of very demanding test cases.

Preliminary Opto-Mechanical Design for the X2000 Transceiver

NASA Technical Reports Server (NTRS)

Hemmati, H.; Page, N. A.

2000-01-01

Preliminary optical design and mechanical conceptual design for a 30 cm aperture transceiver are described. A common aperture is used for both transmit and receive. Special attention was given to off-axis and scattered light rejection and isolation of the receive channel from the transmit channel. Requirements, details of the design and preliminary performance analysis of the transceiver are provided.

Topology Design for Directional Range Extension Networks with Antenna Blockage

DTIC Science & Technology

2017-03-19

introduced by pod-based antenna blockages. Using certain modeling approximations, the paper presents a quantitative analysis showing design trade-offs...parameters. Sec- tion IV develops quantitative relationships among key design elements and performance metrics. Section V considers some implications of the...Topology Design for Directional Range Extension Networks with Antenna Blockage Thomas Shake MIT Lincoln Laboratory shake@ll.mit.edu Abstract

Compliant flow designs for optimum lift control of wind turbine rotors

NASA Astrophysics Data System (ADS)

Williams, Theodore J. H.

An optimization approach was formulated to determine geometric designs that are most compliant to flow control devices. Single dielectric barrier discharge (SDBD) plasma actuators are used in the flow control design optimization as they are able to be incorporated into CFD simulations. An adjoint formulation was derived in order to have a numerically efficient way of calculating the shape derivatives on the surface of the geometric design. The design of a wind turbine blade retrofit for the JIMP 25kW wind turbine at Notre Dame is used to motivate analyses that utilize the optimization approach. The CFD simulations of the existing wind turbine blade were validated against wind tunnel testing. A one-parameter optimization was performed in order to design a trailing edge addition for the current wind turbine blade. The trailing edge addition was designed to meet a desired lift target while maximizing the lift-to-drag ratio. This analysis was performed at seven radial locations on the wind turbine blade. The new trailing edge retrofits were able to achieve the lift target for the outboard radial locations. The designed geometry has been fabricated and is currently being validated on a full-scale turbine and it is predicted to have an increase in annual energy production of 4.30%. The design of a trailing edge retrofit that includes the use of a SDBD plasma actuator was performed using a two-parameter optimization. The objective of this analysis was to meet the lift target and maximize the controllability of the design. The controllability is defined as the difference in lift between plasma on and plasma off cases. A trailing edge retrofit with the plasma actuator located on the pressure side was able to achieve the target passive lift increase while using plasma flow control to reduce the lift to below the original design. This design resulted in a highly compliant flow.

Wind and water tunnel testing of a morphing aquatic micro air vehicle.

PubMed

Siddall, Robert; Ortega Ancel, Alejandro; Kovač, Mirko

2017-02-06

Aerial robots capable of locomotion in both air and water would enable novel mission profiles in complex environments, such as water sampling after floods or underwater structural inspections. The design of such a vehicle is challenging because it implies significant propulsive and structural design trade-offs for operation in both fluids. In this paper, we present a unique Aquatic Micro Air Vehicle (AquaMAV), which uses a reconfigurable wing to dive into the water from flight, inspired by the plunge diving strategy of water diving birds in the family Sulidae . The vehicle's performance is investigated in wind and water tunnel experiments, from which we develop a planar trajectory model. This model is used to predict the dive behaviour of the AquaMAV, and investigate the efficacy of passive dives initiated by wing folding as a means of water entry. The paper also includes first field tests of the AquaMAV prototype where the folding wings are used to initiate a plunge dive.

Wind and water tunnel testing of a morphing aquatic micro air vehicle

PubMed Central

Ortega Ancel, Alejandro; Kovač, Mirko

2017-01-01

Aerial robots capable of locomotion in both air and water would enable novel mission profiles in complex environments, such as water sampling after floods or underwater structural inspections. The design of such a vehicle is challenging because it implies significant propulsive and structural design trade-offs for operation in both fluids. In this paper, we present a unique Aquatic Micro Air Vehicle (AquaMAV), which uses a reconfigurable wing to dive into the water from flight, inspired by the plunge diving strategy of water diving birds in the family Sulidae. The vehicle's performance is investigated in wind and water tunnel experiments, from which we develop a planar trajectory model. This model is used to predict the dive behaviour of the AquaMAV, and investigate the efficacy of passive dives initiated by wing folding as a means of water entry. The paper also includes first field tests of the AquaMAV prototype where the folding wings are used to initiate a plunge dive. PMID:28163877

Application of experimental design for the optimization of artificial neural network-based water quality model: a case study of dissolved oxygen prediction.

PubMed

Šiljić Tomić, Aleksandra; Antanasijević, Davor; Ristić, Mirjana; Perić-Grujić, Aleksandra; Pocajt, Viktor

2018-04-01

This paper presents an application of experimental design for the optimization of artificial neural network (ANN) for the prediction of dissolved oxygen (DO) content in the Danube River. The aim of this research was to obtain a more reliable ANN model that uses fewer monitoring records, by simultaneous optimization of the following model parameters: number of monitoring sites, number of historical monitoring data (expressed in years), and number of input water quality parameters used. Box-Behnken three-factor at three levels experimental design was applied for simultaneous spatial, temporal, and input variables optimization of the ANN model. The prediction of DO was performed using a feed-forward back-propagation neural network (BPNN), while the selection of most important inputs was done off-model using multi-filter approach that combines a chi-square ranking in the first step with a correlation-based elimination in the second step. The contour plots of absolute and relative error response surfaces were utilized to determine the optimal values of design factors. From the contour plots, two BPNN models that cover entire Danube flow through Serbia are proposed: an upstream model (BPNN-UP) that covers 8 monitoring sites prior to Belgrade and uses 12 inputs measured in the 7-year period and a downstream model (BPNN-DOWN) which covers 9 monitoring sites and uses 11 input parameters measured in the 6-year period. The main difference between the two models is that BPNN-UP utilizes inputs such as BOD, P, and PO 4 3- , which is in accordance with the fact that this model covers northern part of Serbia (Vojvodina Autonomous Province) which is well-known for agricultural production and extensive use of fertilizers. Both models have shown very good agreement between measured and predicted DO (with R 2  ≥ 0.86) and demonstrated that they can effectively forecast DO content in the Danube River.

The siRNA Non-seed Region and Its Target Sequences Are Auxiliary Determinants of Off-Target Effects.

PubMed

Kamola, Piotr J; Nakano, Yuko; Takahashi, Tomoko; Wilson, Paul A; Ui-Tei, Kumiko

2015-12-01

RNA interference (RNAi) is a powerful tool for post-transcriptional gene silencing. However, the siRNA guide strand may bind unintended off-target transcripts via partial sequence complementarity by a mechanism closely mirroring micro RNA (miRNA) silencing. To better understand these off-target effects, we investigated the correlation between sequence features within various subsections of siRNA guide strands, and its corresponding target sequences, with off-target activities. Our results confirm previous reports that strength of base-pairing in the siRNA seed region is the primary factor determining the efficiency of off-target silencing. However, the degree of downregulation of off-target transcripts with shared seed sequence is not necessarily similar, suggesting that there are additional auxiliary factors that influence the silencing potential. Here, we demonstrate that both the melting temperature (Tm) in a subsection of siRNA non-seed region, and the GC contents of its corresponding target sequences, are negatively correlated with the efficiency of off-target effect. Analysis of experimentally validated miRNA targets demonstrated a similar trend, indicating a putative conserved mechanistic feature of seed region-dependent targeting mechanism. These observations may prove useful as parameters for off-target prediction algorithms and improve siRNA 'specificity' design rules.

Wide-Field-of-View Millimeter-Wave Telescope Design with Ultra-Low Cross-Polarization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bernacki, Bruce E.; Kelly, James F.; Sheen, David M.

2012-05-01

As millimeter-wave arrays become available, off-axis imaging performance of the fore optics increases in importance due to the relatively large physical extent of the arrays. Typically, simple optical telescope designs are adapted to millimeter-wave imaging but single-mirror spherical or classic conic designs cannot deliver adequate image quality except near the optical axis. Since most millimeter-wave designs are quasi-optical, optical ray tracing and commercial design software can be used to optimize designs to improve off-axis imaging as well as minimize cross-polarization. Methods that obey the Dragone-Mizuguchi condition for the design of reflective millimeter-wave telescopes with low cross-polarization also provide additional degreesmore » of freedom that offer larger fields of view than possible with single-reflector designs. Dragone’s graphical design method does not lend itself readily to computer-based optical design approaches, but subsequent authors expanded on Dragone’s geometric design approach with analytic expressions that describe the location, shape, off-axis height and tilt of the telescope elements that satisfy Dragone’s design rules and can be used as a first-order design for subsequent computer-based design and optimization. We investigate two design variants that obey the Dragone-Mizuguchi conditions that exhibit ultra-low polarization crosstalk and a large diffraction-limited field of view well suited to millimeter-wave imaging arrays.« less

Expanding the Natural Laminar Flow Boundary for Supersonic Transports

NASA Technical Reports Server (NTRS)

Lynde, Michelle N.; Campbell, Richard L.

2016-01-01

A computational design and analysis methodology is being developed to design a vehicle that can support significant regions of natural laminar flow (NLF) at supersonic flight conditions. The methodology is built in the CDISC design module to be used in this paper with the flow solvers Cart3D and USM3D, and the transition prediction modules BLSTA3D and LASTRAC. The NLF design technique prescribes a target pressure distribution for an existing geometry based on relationships between modal instability wave growth and pressure gradients. The modal instability wave growths (both on- and off-axes crossflow and Tollmien-Schlichting) are balanced to produce a pressure distribution that will have a theoretical maximum NLF region for a given streamwise wing station. An example application is presented showing the methodology on a generic supersonic transport wingbody configuration. The configuration has been successfully redesigned to support significant regions of NLF (approximately 40% of the wing upper surface by surface area). Computational analysis predicts NLF with transition Reynolds numbers (ReT) as high as 36 million with 72 degrees of leading-edge sweep (?LE), significantly expanding the current boundary of ReT - ?LE combinations for NLF. This NLF geometry provides a total drag savings of 4.3 counts compared to the baseline wing-body configuration (approximately 5% of total drag). Off-design evaluations at near-cruise and low-speed, high-lift conditions are discussed, as well as attachment line contamination/transition concerns. This computational NLF design effort is a part of an ongoing cooperative agreement between NASA and JAXA researchers.

Power and Performance Trade-offs for Space Time Adaptive Processing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gawande, Nitin A.; Manzano Franco, Joseph B.; Tumeo, Antonino

Computational efficiency – performance relative to power or energy – is one of the most important concerns when designing RADAR processing systems. This paper analyzes power and performance trade-offs for a typical Space Time Adaptive Processing (STAP) application. We study STAP implementations for CUDA and OpenMP on two computationally efficient architectures, Intel Haswell Core I7-4770TE and NVIDIA Kayla with a GK208 GPU. We analyze the power and performance of STAP’s computationally intensive kernels across the two hardware testbeds. We also show the impact and trade-offs of GPU optimization techniques. We show that data parallelism can be exploited for efficient implementationmore » on the Haswell CPU architecture. The GPU architecture is able to process large size data sets without increase in power requirement. The use of shared memory has a significant impact on the power requirement for the GPU. A balance between the use of shared memory and main memory access leads to an improved performance in a typical STAP application.« less

Design Trade Study for a 4-Meter Off-Axis Primary Mirror Substrate and Mount for the Habitable-Zone Exoplanet Direct Imaging Mission

NASA Technical Reports Server (NTRS)

Arnold, William R.; Stahl, H. Philip

2017-01-01

An extensive trade study was conducted to evaluate primary mirror substrate design architectures for the HabEx mission baseline 4-meter off-axis telescope. The study’s purpose is not to produce a final design, but rather to established a design methodology for matching the mirror’s properties (mass and stiffness) with the mission’s optical performance specifications (static dynamic wavefront error, WFE). The study systematically compares the effect of proven design elements (closed-back vs. open-back vs. partial-back; meniscus vs. flat back vs. shaped back; etc.), which can be implemented with proven space mirror materials (ULE and Zerodur), on static and dynamic WFE. Additionally, the study compares static and dynamic WFE of each substrate point design integrated onto three and six point mounts.

Design trade study for a 4-meter off-axis primary mirror substrate and mount for the Habitable-zone Exoplanet Direct Imaging Mission

NASA Astrophysics Data System (ADS)

Arnold, William R.; Stahl, H. Philip

2017-09-01

An extensive trade study was conducted to evaluate primary mirror substrate design architectures for the HabEx mission baseline 4-meter off-axis telescope. The study's purpose is not to produce a final design, but rather to established a design methodology for matching the mirror's properties (mass and stiffness) with the mission's optical performance specifications (static dynamic wavefront error, WFE). The study systematically compares the effect of proven design elements (closed-back vs open-back vs partial-back; meniscus vs flat back vs shaped back; etc.), which can be implemented with proven space mirror materials (ULE and Zerodur), on static and dynamic WFE. Additionally, the study compares static and dynamic WFE of each substrate point design integrated onto three and six point mounts.

Thermal control system of the Exoplanet Characterisation Observatory Payload: design and predictions

NASA Astrophysics Data System (ADS)

Morgante, G.; Terenzi, L.; Eccleston, P.; Bradshaw, T.; Crook, M.; Linder, M.; Hunt, T.; Winter, B.; Focardi, M.; Malaguti, G.; Micela, G.; Pace, E.; Tinetti, G.

2015-12-01

The Exoplanet Characterisation Observatory (EChO) is a space mission dedicated to investigate exoplanetary atmospheres by undertaking spectroscopy of transiting planets in a wide spectral region from the visible to the mid-InfraRed (IR). The high sensitivity and the long exposures required by the mission need an extremely stable thermo-mechanical platform. The instrument is passively cooled down to approximately 40 K, together with the telescope assembly, by a V-Groove based design that exploits the L2 orbit favourable thermal conditions. The visible and short-IR wavelength detectors are maintained at the operating temperature of 40 K by a dedicated radiator coupled to the cold space. The mid-IR channels, require a lower operating temperature and are cooled by an active refrigerator: a 28 K Neon Joule-Thomson (JT) cold end, fed by a mechanical compressor. Temperature stability is one of the challenging issues of the whole architecture: periodical perturbations must be controlled before they reach the sensitive units of the instrument. An efficient thermal control system is required: the design is based on a combination of passive and active solutions. In this paper we describe the thermal architecture of the payload with the main cryo-chain stages and their temperature control systems. The requirements that drive the design and the trade-offs needed to enable the EChO exciting science in a technically feasible payload design are discussed. Thermal modelling results and preliminary performance predictions in terms of steady state and transient conditions are also reported. This paper is presented on behalf of the EChO Consortium.

Integrated active and passive control design methodology for the LaRC CSI evolutionary model

NASA Technical Reports Server (NTRS)

Voth, Christopher T.; Richards, Kenneth E., Jr.; Schmitz, Eric; Gehling, Russel N.; Morgenthaler, Daniel R.

1994-01-01

A general design methodology to integrate active control with passive damping was demonstrated on the NASA LaRC CSI Evolutionary Model (CEM), a ground testbed for future large, flexible spacecraft. Vibration suppression controllers designed for Line-of Sight (LOS) minimization were successfully implemented on the CEM. A frequency-shaped H2 methodology was developed, allowing the designer to specify the roll-off of the MIMO compensator. A closed loop bandwidth of 4 Hz, including the six rigid body modes and the first three dominant elastic modes of the CEM was achieved. Good agreement was demonstrated between experimental data and analytical predictions for the closed loop frequency response and random tests. Using the Modal Strain Energy (MSE) method, a passive damping treatment consisting of 60 viscoelastically damped struts was designed, fabricated and implemented on the CEM. Damping levels for the targeted modes were more than an order of magnitude larger than for the undamped structure. Using measured loss and stiffness data for the individual damped struts, analytical predictions of the damping levels were very close to the experimental values in the (1-10) Hz frequency range where the open loop model matched the experimental data. An integrated active/passive controller was successfully implemented on the CEM and was evaluated against an active-only controller. A two-fold increase in the effective control bandwidth and further reductions of 30 percent to 50 percent in the LOS RMS outputs were achieved compared to an active-only controller. Superior performance was also obtained compared to a High-Authority/Low-Authority (HAC/LAC) controller.

Coordination of push-off and collision determine the mechanical work of step-to-step transitions when isolated from human walking.

PubMed

Soo, Caroline H; Donelan, J Maxwell

2012-02-01

In human walking, each transition to a new stance limb requires redirection of the center of mass (COM) velocity from one inverted pendulum arc to the next. While this can be accomplished with either negative collision work by the leading limb, positive push-off work by the trailing limb, or some combination of the two, physics-based models of step-to-step transitions predict that total positive work is minimized when the push-off and collision work are equal in magnitude. Here, we tested the importance of the coordination of push-off and collision work in determining transition work using ankle and knee joint braces to limit the ability of a leg to perform positive work on the body. To isolate transitions from other contributors to walking mechanics, participants were instructed to rock back and forth from one leg to the other, restricting motion to the sagittal plane and eliminating the need to swing the legs. We found that reduced push-off work increased the collision work required to complete the redirection of the COM velocity during each transition. A greater amount of total mechanical work was required when rocking departed from the predicted optimal coordination of step-to-step transitions, in which push-off and collision work are equal in magnitude. Our finding that transition work increases if one or both legs do not push-off with the optimal coordination may help explain the elevated metabolic cost of pathological gait irrespective of etiology. Copyright © 2011 Elsevier B.V. All rights reserved.

Design of an Object-Oriented Turbomachinery Analysis Code: Initial Results

NASA Technical Reports Server (NTRS)

Jones, Scott

2015-01-01

Performance prediction of turbomachines is a significant part of aircraft propulsion design. In the conceptual design stage, there is an important need to quantify compressor and turbine aerodynamic performance and develop initial geometry parameters at the 2-D level prior to more extensive Computational Fluid Dynamics (CFD) analyses. The Object-oriented Turbomachinery Analysis Code (OTAC) is being developed to perform 2-D meridional flowthrough analysis of turbomachines using an implicit formulation of the governing equations to solve for the conditions at the exit of each blade row. OTAC is designed to perform meanline or streamline calculations; for streamline analyses simple radial equilibrium is used as a governing equation to solve for spanwise property variations. While the goal for OTAC is to allow simulation of physical effects and architectural features unavailable in other existing codes, it must first prove capable of performing calculations for conventional turbomachines.OTAC is being developed using the interpreted language features available in the Numerical Propulsion System Simulation (NPSS) code described by Claus et al (1991). Using the NPSS framework came with several distinct advantages, including access to the pre-existing NPSS thermodynamic property packages and the NPSS Newton-Raphson solver. The remaining objects necessary for OTAC were written in the NPSS framework interpreted language. These new objects form the core of OTAC and are the BladeRow, BladeSegment, TransitionSection, Expander, Reducer, and OTACstart Elements. The BladeRow and BladeSegment consumed the initial bulk of the development effort and required determining the equations applicable to flow through turbomachinery blade rows given specific assumptions about the nature of that flow. Once these objects were completed, OTAC was tested and found to agree with existing solutions from other codes; these tests included various meanline and streamline comparisons of axial compressors and turbines at design and off-design conditions.

Design of an Object-Oriented Turbomachinery Analysis Code: Initial Results

NASA Technical Reports Server (NTRS)

Jones, Scott M.

2015-01-01

Performance prediction of turbomachines is a significant part of aircraft propulsion design. In the conceptual design stage, there is an important need to quantify compressor and turbine aerodynamic performance and develop initial geometry parameters at the 2-D level prior to more extensive Computational Fluid Dynamics (CFD) analyses. The Object-oriented Turbomachinery Analysis Code (OTAC) is being developed to perform 2-D meridional flowthrough analysis of turbomachines using an implicit formulation of the governing equations to solve for the conditions at the exit of each blade row. OTAC is designed to perform meanline or streamline calculations; for streamline analyses simple radial equilibrium is used as a governing equation to solve for spanwise property variations. While the goal for OTAC is to allow simulation of physical effects and architectural features unavailable in other existing codes, it must first prove capable of performing calculations for conventional turbomachines. OTAC is being developed using the interpreted language features available in the Numerical Propulsion System Simulation (NPSS) code described by Claus et al (1991). Using the NPSS framework came with several distinct advantages, including access to the pre-existing NPSS thermodynamic property packages and the NPSS Newton-Raphson solver. The remaining objects necessary for OTAC were written in the NPSS framework interpreted language. These new objects form the core of OTAC and are the BladeRow, BladeSegment, TransitionSection, Expander, Reducer, and OTACstart Elements. The BladeRow and BladeSegment consumed the initial bulk of the development effort and required determining the equations applicable to flow through turbomachinery blade rows given specific assumptions about the nature of that flow. Once these objects were completed, OTAC was tested and found to agree with existing solutions from other codes; these tests included various meanline and streamline comparisons of axial compressors and turbines at design and off-design conditions.

The DOE/NASA wind turbine data acquisition system. Part 3: Unattended power performance monitor

NASA Technical Reports Server (NTRS)

Halleyy, A.; Heidkamp, D.; Neustadter, H.; Olson, R.

1983-01-01

Software documentation, operational procedures, and diagnostic instructions for development version of an unattended wind turbine performance monitoring system is provided. Designed to be used for off line intelligent data acquisition in conjunction with the central host computer.

Study on off-axis detection of pulsed laser in atmosphere

NASA Astrophysics Data System (ADS)

Liang, Weiwei

2018-02-01

Laser communication, designation, and ranging are point to point and have a high degree of specificity, current laser detection, such as laser warning receiver system, could detect the scattering laser from the off-axis distance by scattering track on natural aerosols, which is helpful to locate the laser source. However, the intensity of the scattering laser is extremely weak and affected by many factors, in order to evaluate the detection characteristic, a simplified model of off-axis detection for scattering laser in the lower atmosphere based on the Mie scattering theory is presented in this paper, the performances of the off-axis laser detection in different conditions such as off-axis distance, visibility, incidence angle, and delay time are investigated.

First charge breeding results at CARIBU EBIS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kondrashev, S., E-mail: kondrashev@anl.gov; Barcikowski, A., E-mail: kondrashev@anl.gov; Dickerson, C., E-mail: kondrashev@anl.gov

The Electron Beam Ion Source (EBIS) developed to breed CARIBU radioactive beams at ATLAS is currently in the off-line commissioning stage. The beam commissioning is being performed using a low emittance surface ionization source producing singly-charged cesium ions. The primary goal of the off-line commissioning is the demonstration of high-efficiency charge breeding in the pulsed injection mode. An overview of the final design of the CARIBU EBIS charge breeder, the off-line commissioning installation and the first results on charge breeding of stable cesium ions are presented and discussed.

Design and test of a high performance off-axis TMA telescope

NASA Astrophysics Data System (ADS)

Fan, Bin; Cai, Wei-jun; Huang, Ying

2017-11-01

A new complete Optical Demonstration Model (ODM) of high performance off-axis Three Mirror Anastigmatic (TMA) telescope has been successfully developed in BISME. This 1.75-m focal length, 1/9 relative aperture, 6.2°×1.0°field of view visible telescope, which uses the TDICCD detectors of 7μm pixel size, can provide 2.0-m ground sampling distance and 51-km swath from an altitude of 500 km. With some significant efforts, the main goals of the ODM have been reached: a compact lightweight design while realizing high performance and high stability. The optical system and key technologies have been applied in the multispectral camera of ZY-3 Satellite (the first high resolution stereo mapping satellite of China), which was successfully launched on January 9th, 2012. The main technology of ODM was described. The test results and applications were outlined.

A simple method for astigmatic compensation of folded resonator without Brewster window.

PubMed

Qiao, Wen; Xiaojun, Zhang; Yonggang, Wang; Liqun, Sun; Hanben, Niu

2014-02-10

A folded resonator requires an oblique angle of incidence on the folded curved mirror, which introduces astigmatic distortions that limit the performance of the lasers. We present a simple method to compensate the astigmatism of folded resonator without Brewster windows for the first time to the best of our knowledge. Based on the theory of the propagation and transformation of Gaussian beams, the method is both effective and reliable. Theoretical results show that the folded resonator can be compensated astigmatism completely when the following two conditions are fulfilled. Firstly, when the Gaussian beam with a determined size beam waist is obliquely incident on an off-axis concave mirror, two new Gaussian beam respectively in the tangential and sagittal planes are formed. Another off-axis concave mirror is located at another intersection point of the two new Gaussian beams. Secondly, adjusting the incident angle of the second concave mirror or its focal length can make the above two Gaussian beam coincide in the image plane of the second concave mirror, which compensates the astigmatic aberration completely. A side-pumped continues-wave (CW) passively mode locked Nd:YAG laser was taken as an example of the astigmatically compensated folded resonators. The experimental results show good agreement with the theoretical predictions. This method can be used effectively to design astigmatically compensated cavities resonator of high-performance lasers.

Analysis of impact of general-purpose graphics processor units in supersonic flow modeling

NASA Astrophysics Data System (ADS)

Emelyanov, V. N.; Karpenko, A. G.; Kozelkov, A. S.; Teterina, I. V.; Volkov, K. N.; Yalozo, A. V.

2017-06-01

Computational methods are widely used in prediction of complex flowfields associated with off-normal situations in aerospace engineering. Modern graphics processing units (GPU) provide architectures and new programming models that enable to harness their large processing power and to design computational fluid dynamics (CFD) simulations at both high performance and low cost. Possibilities of the use of GPUs for the simulation of external and internal flows on unstructured meshes are discussed. The finite volume method is applied to solve three-dimensional unsteady compressible Euler and Navier-Stokes equations on unstructured meshes with high resolution numerical schemes. CUDA technology is used for programming implementation of parallel computational algorithms. Solutions of some benchmark test cases on GPUs are reported, and the results computed are compared with experimental and computational data. Approaches to optimization of the CFD code related to the use of different types of memory are considered. Speedup of solution on GPUs with respect to the solution on central processor unit (CPU) is compared. Performance measurements show that numerical schemes developed achieve 20-50 speedup on GPU hardware compared to CPU reference implementation. The results obtained provide promising perspective for designing a GPU-based software framework for applications in CFD.

Investigation of non-axisymmetric endwall contouring in a compressor cascade

NASA Astrophysics Data System (ADS)

Liu, Xiwu; Jin, Donghai; Gui, Xingmin

2017-12-01

The current paper presents experimental and computational results to assess the effectiveness of non-axisymmetric endwall contouring in a compressor linear cascade. The endwall was designed by an endwall design optimization platform at 0o incidence (design condition). The optimization method is based on a genetic algorithm. The design objective was to minimize the total pressure losses. The experiments were carried out in a compressor cascade at a low-speed test facility with a Mach number of 0.15. Four nominal inlet flow angles were chosen to test the performance of non-axisymmetric Contoured Endwall (CEW). A five-hole pressure probe with a head diameter of 2 mm was used to traverse the downstream flow fields of the flat-endwall (FEW) and CEW cascades. Both the measured and predicted results indicated that the implementation of CEW results in smaller corner stall, and reduction of total pressure losses. The CEW gets 15.6% total pressure loss coefficient reduction at design condition, and 22.6% at off-design condition (+7o incidence). And the mechanism of the improvement of CEW based on both measured and calculated results is that the adverse pressure gradient (APG) has been reduced through the groove configuration near the leading edge (LE) of the suction surface (SS).

NIR technique in the classification of cotton leaf grade

USDA-ARS?s Scientific Manuscript database

Near infrared (NIR) spectroscopy, a useful technique due to the speed, ease of use, and adaptability to on-line or off-line implementation, has been applied to perform the qualitative classification and quantitative prediction of cotton quality characteristics, including trash index. One term to as...

Maneuver Automation Software

NASA Technical Reports Server (NTRS)

Uffelman, Hal; Goodson, Troy; Pellegrin, Michael; Stavert, Lynn; Burk, Thomas; Beach, David; Signorelli, Joel; Jones, Jeremy; Hahn, Yungsun; Attiyah, Ahlam;

Study of an advanced General Aviation Turbine Engine (GATE)

NASA Technical Reports Server (NTRS)

Gill, J. C.; Short, F. R.; Staton, D. V.; Zolezzi, B. A.; Curry, C. E.; Orelup, M. J.; Vaught, J. M.; Humphrey, J. M.

1979-01-01

The best technology program for a small, economically viable gas turbine engine applicable to the general aviation helicopter and aircraft market for 1985-1990 was studied. Turboshaft and turboprop engines in the 112 to 746 kW (150 to 1000 hp) range and turbofan engines up to 6672 N (1500 lbf) thrust were considered. A good market for new turbine engines was predicted for 1988 providing aircraft are designed to capitalize on the advantages of the turbine engine. Parametric engine families were defined in terms of design and off-design performance, mass, and cost. These were evaluated in aircraft design missions selected to represent important market segments for fixed and rotary-wing applications. Payoff parameters influenced by engine cycle and configuration changes were aircraft gross mass, acquisition cost, total cost of ownership, and cash flow. Significant advantage over a current technology, small gas turbine engines was found especially in cost of ownership and fuel economy for airframes incorporating an air-cooled high-pressure ratio engine. A power class of 373 kW (500 hp) was recommended as the next frontier for technology advance where large improvements in fuel economy and engine mass appear possible through component research and development.

Technical Evaluation Report, Part A - Vortex Flow and High Angle of Attack

NASA Technical Reports Server (NTRS)

Luckring, James M.

2003-01-01

A symposium entitled Vortex Flow and High Angle of Attack was held in Loen, Norway, from May 7 through May 11, 2001. The Applied Vehicle Technology (AVT) panel, under the auspices of the Research and Technology Organization (RTO), sponsored this symposium. Forty-eight papers, organized into nine sessions, addressed computational and experimental studies of vortex flows pertinent to both aircraft and maritime applications. The studies also ranged from fundamental fluids investigations to flight test results, and significant results were contributed from a broad range of countries. The principal emphasis of this symposium was on "the understanding and prediction of separation-induced vortex flows and their effects on military vehicle performance, stability, control, and structural design loads." It was further observed by the program committee that "separation- induced vortex flows are an important part of the design and off-design performance of conventional fighter aircraft and new conventional or unconventional manned or unmanned advanced vehicle designs (UAVs, manned aircraft, missiles, space planes, ground-based vehicles, and ships)." The nine sessions addressed the following topics: vortical flows on wings and bodies, experimental techniques for vortical flows, numerical simulations of vortical flows, vortex stability and breakdown, vortex flows in maritime applications, vortex interactions and control, vortex dynamics, flight testing, and vehicle design. The purpose of this paper is to provide brief reviews of these papers along with some synthesizing perspectives toward future vortex flow research opportunities. The paper includes the symposium program. (15 refs.)

Advanced grid-stiffened composite shells for applications in heavy-lift helicopter rotor blade spars

NASA Astrophysics Data System (ADS)

Narayanan Nampy, Sreenivas

Modern rotor blades are constructed using composite materials to exploit their superior structural performance compared to metals. Helicopter rotor blade spars are conventionally designed as monocoque structures. Blades of the proposed Heavy Lift Helicopter are envisioned to be as heavy as 800 lbs when designed using the monocoque spar design. A new and innovative design is proposed to replace the conventional spar designs with light weight grid-stiffened composite shell. Composite stiffened shells have been known to provide excellent strength to weight ratio and damage tolerance with an excellent potential to reduce weight. Conventional stringer--rib stiffened construction is not suitable for rotor blade spars since they are limited in generating high torsion stiffness that is required for aeroelastic stability of the rotor. As a result, off-axis (helical) stiffeners must be provided. This is a new design space where innovative modeling techniques are needed. The structural behavior of grid-stiffened structures under axial, bending, and torsion loads, typically experienced by rotor blades need to be accurately predicted. The overall objective of the present research is to develop and integrate the necessary design analysis tools to conduct a feasibility study in employing grid-stiffened shells for heavy-lift rotor blade spars. Upon evaluating the limitations in state-of-the-art analytical models in predicting the axial, bending, and torsion stiffness coefficients of grid and grid-stiffened structures, a new analytical model was developed. The new analytical model based on the smeared stiffness approach was developed employing the stiffness matrices of the constituent members of the grid structure such as an arch, helical, or straight beam representing circumferential, helical, and longitudinal stiffeners. This analysis has the capability to model various stiffening configurations such as angle-grid, ortho-grid, and general-grid. Analyses were performed using an existing state-of-the-art and newly developed model to predict the torsion, bending, and axial stiffness of grid and grid-stiffened structures with various stiffening configurations. These predictions were compared to results generated using finite element analysis (FEA) to observe excellent correlation (within 6%) for a range of parameters for grid and grid-stiffened structures such as grid density, stiffener angle, and aspect ratio of the stiffener cross-section. Experimental results from cylindrical grid specimen testing were compared with analytical prediction using the new analysis. The new analysis predicted stiffness coefficients with nearly 7% error compared to FEA results. From the parametric studies conducted, it was observed that the previous state-of-the-art analysis on the other hand exhibited errors of the order of 39% for certain designs. Stability evaluations were also conducted by integrating the new analysis with established stability formulations. A design study was conducted to evaluate the potential weight savings of a simple grid-stiffened rotor blade spar structure compared to a baseline monocoque design. Various design constraints such as stiffness, strength, and stability were imposed. A manual search was conducted for design parameters such as stiffener density, stiffener angle, shell laminate, and stiffener aspect ratio that provide lightweight grid-stiffened designs compared to the baseline. It was found that a weight saving of 9.1% compared to the baseline is possible without violating any of the design constraints.

Performance of serum α-fetoprotein levels in the diagnosis of hepatocellular carcinoma in patients with a hepatic mass

PubMed Central

Chan, Stephen L; Mo, Frankie; Johnson, Philip J; Siu, Deyond Y W; Chan, Michael H M; Lau, Wan Y; Lai, Paul B S; Lam, Christopher W K; Yeo, Winnie; Yu, Simon C H

2014-01-01

Objectives The role of serum α-fetoprotein (AFP) measurements in the diagnosis of hepatocellular carcinoma (HCC) remains controversial. Some guidelines have advised against the use of AFP in the diagnosis of HCC. This study was conducted to evaluate the performance of AFP in the diagnosis of HCC, and to identify the optimal cut-off value of serum AFP in the diagnosis of HCC in patients with a hepatic mass. Methods Patients who presented during the period from May 1997 to March 2003 with hepatic lesions, for whom paired data on serum AFP values at baseline and lesion histology were available, were reviewed. The performance of AFP in the diagnosis of HCC was determined using receiver operating characteristic curve analysis. Results Data for a total of 805 patients were evaluated. The mean AFP value was 26 900 ng/ml (range: 0–1 965 461 ng/ml). The histological diagnosis was HCC in 557 patients. The optimal AFP cut-off value was 10 ng/ml (for sensitivity of 82.6% and specificity of 70.4%). At a cut-off level of 200 ng/ml, sensitivity, specificity, and positive and negative predictive values were 47.7%, 97.1%, 97.5% and 44.4%, respectively. The diagnostic performance of AFP remains similar in patients with chronic hepatitis B virus infection, despite a lower negative predictive value. Common aetiologies of liver lesions associated with elevated AFP include cholangiocarcinoma and neuroendocrine tumours. Conclusions In Asian patients with suspicious liver lesions, the cut-off AFP level of 200 ng/ml is useful to achieve a diagnosis of HCC with high specificity and reasonable sensitivity. The measurement of serum AFP should not be excluded from guidelines for the diagnosis of HCC. PMID:23980880

The evolution of trade-offs under directional and correlational selection.

PubMed

Roff, Derek A; Fairbairn, Daphne J

2012-08-01

Using quantitative genetic theory, we develop predictions for the evolution of trade-offs in response to directional and correlational selection. We predict that directional selection favoring an increase in one trait in a trade-off will result in change in the intercept but not the slope of the trade-off function, with the mean value of the selected trait increasing and that of the correlated trait decreasing. Natural selection will generally favor an increase in some combination of trait values, which can be represented as directional selection on an index value. Such selection induces both directional and correlational selection on the component traits. Theory predicts that selection on an index value will also change the intercept but not the slope of the trade-off function but because of correlational selection, the direction of change in component traits may be in the same or opposite directions. We test these predictions using artificial selection on the well-established trade-off between fecundity and flight capability in the cricket, Gryllus firmus and compare the empirical results with a priori predictions made using genetic parameters from a separate half-sibling experiment. Our results support the predictions and illustrate the complexity of trade-off evolution when component traits are subject to both directional and correlational selection. © 2012 The Author(s). Evolution© 2012 The Society for the Study of Evolution.

Getting off on the right foot: subjective value versus economic value in predicting longitudinal job outcomes from job offer negotiations.

PubMed

Curhan, Jared R; Elfenbein, Hillary Anger; Kilduff, Gavin J

2009-03-01

Although negotiation experiences can affect a negotiator's ensuing attitudes and behavior, little is known about their long-term consequences. Using a longitudinal survey design, the authors tested the degree to which economic and subjective value achieved in job offer negotiations predicts employees' subsequent job attitudes and intentions concerning turnover. Results indicate that subjective value predicts greater compensation satisfaction and job satisfaction and lower turnover intention measured 1 year later. Surprisingly, the economic outcomes that negotiators achieved had no apparent effects on these factors. Implications, limitations, and future directions are discussed. (c) 2009 APA, all rights reserved.

Off-duty deviance: Organizational policies and evidence for two prevention strategies.

PubMed

Lyons, Brian D; Hoffman, Brian J; Bommer, William H; Kennedy, Colby L; Hetrick, Andrea L

2016-04-01

Anecdotal evidence suggests that organizations are increasingly concerned with employee off-duty deviance (ODD), yet management research has rarely investigated this type of deviant behavior. We define ODD as behaviors committed outside the workplace or when off-duty that are deviant by organizational and/or societal standards, jeopardize the employee's status within the organization, and threaten the interests and well-being of the organization and its stakeholders. Three studies are presented to better understand the relevance of ODD to modern organizations and then to understand potential approaches to reduce the incidence of ODD. The first study provides a qualitative review of publicly available ODD policies within the Fortune 500; the results showed that 13.4% of the Fortune 500 had a publicly available ODD policy, with the majority prohibiting criminal forms of ODD to protect the firm's reputation. The next 2 studies examine the efficacy of different approaches to reduce criminal ODD: policy adoption and personnel selection. In the second study, a longitudinal, quasi-experimental design showed a significant-albeit modest-reduction in criminal ODD following the adoption of a conduct policy. In the third and final study, a criterion-related validity design supported the predictive validity of general mental ability and prior deviance in predicting criminal ODD. This compendium of studies provides an initial empirical investigation into ODD and offers implications relevant to the deviance literature, policy development, and personnel selection. (c) 2016 APA, all rights reserved).

Modified Design of Hydroturbine Wicket Gates to Include Liquid Control Jets

NASA Astrophysics Data System (ADS)

Lewis, Bryan; Cimbala, John; Wouden, Alex

2013-11-01

With the ever-increasing penetration of alternative electricity generation, it is becoming more common to operate hydroturbines under off-design conditions in order to maintain stability in the electric power grid. Improving the off-design performance of these turbines is therefore of significant importance. As the runner blades of a Francis hydroturbine pass though the wakes created by the upstream guide vanes (wicket gates and stay vanes), they experience significant changes in the instantaneous values of absolute velocity, flow angle, and pressure. The concept of adding water jets to the trailing edge of the guide vanes is proposed as a method for reducing the dynamic load on the hydroturbine runner blades, as well as modifying the flow angle of the water entering the runner to improve turbine efficiency during off-design operation. In order to add water jets that are capable of turning the flow, a modified beveled trailing edge design is presented. Computational experiments show that a +/-5° change in swirl angle is achievable with the new design, as well as up to 4% improvement in turbine efficiency during off-design operation. This correlates to an overall improvement in machine efficiency of up to 2%, when the losses through the jet channels are taken into account. Funding for this work was provided by the DOD, through the National Defense Science and Engineering Graduate (NDSEG) Fellowship, and the DOE, through the Penn State Hydropower Research Grant.

Receiver operating characteristic analysis of prediction for gastric cancer development using serum pepsinogen and Helicobacter pylori antibody tests.

PubMed

Hamashima, Chisato; Sasazuki, Shizuka; Inoue, Manami; Tsugane, Shoichiro

2017-03-09

Chronic Helicobacter pylori infection plays a central role in the development of gastric cancer as shown by biological and epidemiological studies. The H. pylori antibody and serum pepsinogen (PG) tests have been anticipated to predict gastric cancer development. We determined the predictive sensitivity and specificity of gastric cancer development using these tests. Receiver operating characteristic analysis was performed, and areas under the curve were estimated. The predictive sensitivity and specificity of gastric cancer development were compared among single tests and combined methods using serum pepsinogen and H. pylori antibody tests. From a large-scale population-based cohort of over 100,000 subjects followed between 1990 and 2004, 497 gastric cancer subjects and 497 matched healthy controls were chosen. The predictive sensitivity and specificity were low in all single tests and combination methods. The highest predictive sensitivity and specificity were obtained for the serum PG I/II ratio. The optimal PG I/II cut-off values were 2.5 and 3.0. At a PG I/II cut-off value of 3.0, the sensitivity was 86.9% and the specificity was 39.8%. Even if three biomarkers were combined, the sensitivity was 97.2% and the specificity was 21.1% when the cut-off values were 3.0 for PG I/II, 70 ng/mL for PG I, and 10.0 U/mL for H. pylori antibody. The predictive accuracy of gastric cancer development was low with the serum pepsinogen and H. pylori antibody tests even if these tests were combined. To adopt these biomarkers for gastric cancer screening, a high specificity is required. When these tests are adopted for gastric cancer screening, they should be carefully interpreted with a clear understanding of their limitations.

Aerodynamics for the Mars Phoenix Entry Capsule

NASA Technical Reports Server (NTRS)

Edquist, Karl T.; Desai, Prasun N.; Schoenenberger, Mark

2008-01-01

Pre-flight aerodynamics data for the Mars Phoenix entry capsule are presented. The aerodynamic coefficients were generated as a function of total angle-of-attack and either Knudsen number, velocity, or Mach number, depending on the flight regime. The database was constructed using continuum flowfield computations and data from the Mars Exploration Rover and Viking programs. Hypersonic and supersonic static coefficients were derived from Navier-Stokes solutions on a pre-flight design trajectory. High-altitude data (free-molecular and transitional regimes) and dynamic pitch damping characteristics were taken from Mars Exploration Rover analysis and testing. Transonic static coefficients from Viking wind tunnel tests were used for capsule aerodynamics under the parachute. Static instabilities were predicted at two points along the reference trajectory and were verified by reconstructed flight data. During the hypersonic instability, the capsule was predicted to trim at angles as high as 2.5 deg with an on-axis center-of-gravity. Trim angles were predicted for off-nominal pitching moment (4.2 deg peak) and a 5 mm off-axis center-ofgravity (4.8 deg peak). Finally, hypersonic static coefficient sensitivities to atmospheric density were predicted to be within uncertainty bounds.