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Sample records for oligodendroglial component gbm-o

  1. Quantitative chromatin pattern description in Feulgen-stained nuclei as a diagnostic tool to characterize the oligodendroglial and astroglial components in mixed oligo-astrocytomas.

    PubMed

    Decaestecker, C; Lopes, B S; Gordower, L; Camby, I; Cras, P; Martin, J J; Kiss, R; VandenBerg, S R; Salmon, I

    1997-04-01

    The oligoastrocytoma, as a mixed glioma, represents a nosologic dilemma with respect to precisely defining the oligodendroglial and astroglial phenotypes that constitute the neoplastic cell lineages of these tumors. In this study, cell image analysis with Feulgen-stained nuclei was used to distinguish between oligodendroglial and astrocytic phenotypes in oligodendrogliomas and astrocytomas and then applied to mixed oligoastrocytomas. Quantitative features with respect to chromatin pattern (30 variables) and DNA ploidy (8 variables) were evaluated on Feulgen-stained nuclei in a series of 71 gliomas using computer-assisted microscopy. These included 32 oligodendrogliomas (OLG group: 24 grade II and 8 grade III tumors according to the WHO classification), 32 astrocytomas (AST group: 13 grade II and 19 grade III tumors), and 7 oligoastrocytomas (OLGAST group). Initially, image analysis with multivariate statistical analyses (Discriminant Analysis) could identify each glial tumor group. Highly significant statistical differences were obtained distinguishing the morphonuclear features of oligodendrogliomas from those of astrocytomas, regardless of their histological grade. When compared with the 7 mixed oligoastrocytomas under study, 5 exhibited DNA ploidy and chromatin pattern characteristics similar to grade II oligodendrogliomas, I to grade III oligodendrogliomas, and I to grade II astrocytomas. Using multifactorial statistical analyses (Discriminant Analysis combined with Principal Component Analysis). It was possible to quantify the proportion of "typical" glial cell phenotypes that compose grade II and III oligodendrogliomas and grade II and III astrocytomas in each mixed glioma. Cytometric image analysis may be an important adjunct to routine histopathology for the reproducible identification of neoplasms containing a mixture of oligodendroglial and astrocytic phenotypes.

  2. Oligodendroglial degeneration in distemper: apoptosis or necrosis?

    PubMed

    Schobesberger, M; Zurbriggen, A; Summerfield, A; Vandevelde, M; Griot, C

    1999-03-01

    Canine distemper virus (CDV) causes a multifocal demyelinating disease in dogs. It was previously shown that the initial demyelinating lesions are directly virus induced since a correlation between the occurrence of demyelination and CDV replication in white matter cells was observed. During the course of infection oligodendrocytes undergo distinct morphological alterations, partly due to a restricted CDV infection of these cells, and eventually disappear from the lesions. This phenomenon has been described in vivo as well as in vitro. However, the reason for the morphological alterations and the following oligodendroglial depletion remained unclear. Since virus infection can induce cell death, it was investigated whether apoptosis or necrosis plays a role in the pathogenesis of demyelination in canine distemper. In brain tissue sections from dogs with acute distemper apoptotic cells were not detected within the demyelinating lesions using morphological and biochemical cell death criteria. In chronic distemper, apoptotic cells - presumably inflammatory cells - were seen within the perivascular cuffs. These in vivo findings were correlated to the in vitro situation using CDV-infected primary dog brain cell cultures as well as Vero cells. Infection with culture-adapted CDV lead to massive necrosis but not to apoptosis. After infection with virulent CDV neither apoptosis nor necrosis was a predominant feature in either culture system. These findings suggest that virus-induced demyelination in canine distemper is not the direct consequence of apoptosis or necrosis. It is speculated that another mechanism must be responsible for the observed morphological alterations of oligodendrocytes, ultimately leading to demyelination.

  3. Not all 1p/19q non-codeleted oligodendroglial tumors are astrocytic

    PubMed Central

    Aibaidula, Abudumijiti; Chen, Hong; Tang, Qisheng; Li, Kay Ka-Wai; Chung, Nellie Yuk-Fei; Chan, Danny Tat-Ming; Poon, Wai Sang; Mao, Ying; Wu, Jinsong; Zhou, Liangfu; Chan, Aden Ka-yin; Ng, Ho-Keung

    2016-01-01

    Although 1p/19q codeletion is the genetic hallmark defining oligodendrogliomas, approximately 30-40% of oligodendroglial tumors have intact 1p/19q in the literature and they demonstrate a worse prognosis. This group of 1p/19q intact oligodendroglial tumors is frequently suggested to be astrocytic in nature with TP53 and ATRX mutations but actually remains under-investigated. In the present study, we provided evidence that not all 1p/19q intact oligodendroglial tumors are astrocytic through histologic and molecular approaches. We examined 1p/19q status by FISH in a large cohort of 337 oligodendroglial tumors and identified 39.8% lacking 1p/19q codeletion which was independently associated with poor prognosis. Among this 1p/19q intact oligodendroglial tumor cohort, 58 cases demonstrated classic oligodendroglial histology which showed older patient age, better prognosis, association with grade III histology, PDGFRA expression, TERTp mutation, as well as frequent IDH mutation. More than half of the 1p/19q intact oligodendroglial tumors showed lack of astrocytic defining markers, p53 expression and ATRX loss. TP53 mutational analysis was additionally conducted in 45 cases of the 1p/19q intact oligodendroglial tumors. Wild-type TP53 was detected in 71.1% of cases which was associated with classic oligodendroglial histology. Importantly, IDH and TERTp co-occurred in 75% of 1p/19q intact, TP53 wild-type oligodendrogliomas, highlighting the potential of the co-mutations in assisting diagnosis of oligodendrogliomas in tumors with clear cell morphology and non-codeleted 1p/19q status. In summary, our study demonstrated that not all 1p/19q intact oligodendroglial tumors are astrocytic and co-evaluation of IDH and TERTp mutation could potentially serve as an adjunct for diagnosing 1p/19q intact oligodendrogliomas. PMID:27556304

  4. Oligodendroglial MCT1 and Metabolic Support of Axons in Multiple Sclerosis

    DTIC Science & Technology

    2015-10-01

    AWARD NUMBER: W81XWH-14-1-0524 TITLE:Oligodendroglial MCT1 and Metabolic Support of Axons in Multiple Sclerosis PRINCIPAL INVESTIGATOR: Jeffrey D...29 Sep 2015 4. TITLE AND SUBTITLE Oligodendroglial MCT1 and Metabolic Support of Axons in Multiple Sclerosis 5a. CONTRACT NUMBER W81XWH-14-1-0524...MCT1 in injured oligodendroglia of multiple sclerosis patients contributes to axon neurodegeneration and that increasing MCT1 will be protective in the

  5. Bcl-2-related protein family gene expression during oligodendroglial differentiation.

    PubMed

    Itoh, Takayuki; Itoh, Aki; Pleasure, David

    2003-06-01

    Oligodendroglial lineage cells (OLC) vary in susceptibility to both necrosis and apoptosis depending on their developmental stages, which might be regulated by differential expression of Bcl-2-related genes. As an initial step to test this hypothesis, we examined the expression of 19 Bcl-2-related genes in purified cultures of rat oligodendroglial progenitors, immature and mature oligodendrocytes. All 'multidomain' anti-apoptotic members (Bcl-x, Bcl-2, Mcl-1, Bcl-w and Bcl2l10/Diva/Boo) except Bcl2a1/A1 are expressed in OLC. Semiquantitative and real-time RT-PCR revealed that Bcl-xL and Mcl-1 mRNAs are the dominant anti-apoptotic members and increase four- and twofold, respectively, with maturation. Bcl-2 mRNA is less abundant than Bcl-xL mRNA in progenitors and falls an additional 10-fold during differentiation. Bcl-w mRNA also increases, with significant changes in its splicing pattern, as OLC mature. Transfection studies demonstrated that Bcl-xL overexpression protects against kainate-induced excitotoxicity, whereas Bcl-2 overexpression does not. As for 'multidomain' pro-apoptotic members (Bax, Bad and Bok/Mtd), Bax and Bak are highly expressed throughout differentiation. Among 'BH3 domain-only' members examined (Bim, Biklk, DP5/Hrk, Bad, Bid, Noxa, Puma/Bbc3, Bmf, BNip3 and BNip3L), BNip3 and Bmf mRNAs increase markedly during differentiation. These results provide basic information to guide further studies on the roles for Bcl-2-related family proteins in OLC death.

  6. Polysomy of chromosomes 1 and 19: an underestimated prognostic factor in oligodendroglial tumors.

    PubMed

    Jiang, Haihui; Ren, Xiaohui; Zhang, Zhe; Zeng, Wei; Wang, Junmei; Lin, Song

    2014-10-01

    The clinical significance of chromosomes 1 and 19 deletion was well established in oligodendroglial tumors (ODGs). This study was designed to evaluate the prognostic implication of chromosomes 1 and 19 polysomy in gliomas. 584 patients with histological diagnosis of primary gliomas enrolled in the study. Chromosomes 1 and 19 status was detected with fluorescence in situ hybridization (FISH). Of the 584 cases, the frequency of 1q and 19p polysomy in mixed gliomas was significantly higher than ODGs or astrocytic tumors (1q P = 0.032 and P = 0.044; 19p P = 0.024 and P = 0.027); the frequency of 1q and 19p polysomy in low-grade gliomas (WHO II) was relatively lower compared with WHO III or WHO IV (1q P = 0.097 and P = 0.026; 19p P = 0.04 and P = 0.002). 1q, 19p and co-polysomy were confirmed as risk factors conveyed unfavorable outcomes, which has been further validated in both anaplastic oligodendroglial tumors (AOGs) (P = 0.07, P = 0.028 and P = 0.054 for PFS; P = 0.007, P = 0.001 and P = 0.002 for OS, respectively) and glioblastomas with oligodendroglioma component (GBMOs) (P = 0.005, P < 0.001 and P < 0.001 for PFS; P = 0.136, P = 0.006 and P = 0.051 for OS, respectively). Based on chromosomes 1/19 co-deletion and co-polysomy, AOGs and GBMOs could be divided into three subgroups which harbored distinct prognosis (AOGs P < 0.001 for PFS and P < 0.001 for OS; GBMOs P < 0.001 for PFS and P = 0.012 for OS). Chromosomes 1/19 polysomy are potential prognostic factors which confer unfavorable outcomes. The molecular prognostic grouping model based on chromosomes 1/19 co-polysomy and co-deletion better predicts prognosis and provides a more reliable information for treatment decision-making.

  7. Prodegenerative IκBα expression in oligodendroglial α-synuclein models of multiple system atrophy

    PubMed Central

    Kragh, Christine L.; Gysbers, Amanda M.; Rockenstein, Edward; Murphy, Karen; Halliday, Glenda M.; Masliah, Eliezer; Jensen, Poul Henning

    2016-01-01

    Multiple system atrophy is a progressive, neurodegenerative disease characterized by parkinsonism, ataxia, autonomic dysfunction, and accumulation of α-synuclein in oligodendrocytes. To understand how α-synuclein aggregates impact oligodendroglial homeostasis, we investigated an oligodendroglial cell model of α-synuclein dependent degeneration and identified responses linked to the NF-κB transcription factor stress system. Coexpression of human α-synuclein and the oligodendroglial protein p25α increased the expression of IκBα mRNA and protein early during the degenerative process and this was dependent on both aggregation and Ser129 phosphorylation of α-synuclein. This response was prodegenerative because blocking IκBα expression by siRNA rescued the cells. IκBα is an inhibitor of NF-κB and acts by binding and retaining NF-κB p65 in the cytoplasm. The protection obtained by silencing IκBα was accompanied by a strong increase in nuclear p65 translocation indicating that NF-κB activation protects against α-synuclein aggregate stress. In the cellular model, two different phenotypes were observed; degenerating cells retracting their microtubules and resilient cells tolerating the coexpression of α-synuclein and p25α. The resilient cells displayed a significant higher nuclear translocation of p65 and activation of the NF-κB system relied on stress elicited by aggregated and Ser129 phosphorylated α-synuclein. To validate the relationship between oligodendroglial α-synuclein expression and IκBα, we analyzed two different lines of transgenic mice expressing human α-synuclein under the control of the oligodendrocytic MBP promotor (intermediate-expresser line 1 and high-expresser line 29). IκBα mRNA expression was increased in both lines and immunofluorescence microscopy and in situ hybridization revealed that IκBα mRNA and protein is expressed in oligodendrocytes. IκBα mRNA expression was demonstrated prior to activation of microglia and

  8. Oligodendroglial cell proliferation arising in an ovarian mature cystic teratoma. Clinicopathological, inmunohistochemical, and ultrastructural study of a case that may represent an oligodendroglioma.

    PubMed

    Serrano-Arévalo, Mónica Lizzette; Lino-Silva, Leonardo Saúl; Domínguez Malagón, Hugo Ricardo

    2017-01-01

    Ovarian mature cystic teratoma (OMCT) is an ovarian benign neoplasm with excellent prognosis presenting components of the three germinal layers. However, transformation into a malignant neoplasm is a rare event (so-called somatic transformation). In most of the cases, the malignant component expresses as epidermoid carcinoma, but occasionally central nervous system tumors occur. Some of the previously reported tumors are astrocytoma, glioblastoma, and ependymoma. Somatic transformation of OMCT into an oligodendroglioma is exceptional. We report a 19-year-old female with a left OMCT with an area of oligonedroglial cells proliferation characterized by immunohistochemical studies with positivity for GFAP and S100, with a low Ki67 index (5%). Additionally, electron microscopy revealed oligodendrocytes with parallel bundles of cytoplasmic intermediate filaments, confirming the oligodendroglial nature of the proliferation. The patient was treated only with left oophorectomy, and three and half years after surgery, there is no evidence of disease.

  9. Disseminated oligodendroglial-like leptomeningeal tumor with anaplastic progression and presumed extraneural disease: case report.

    PubMed

    Kessler, Brice A; Bookhout, Christine; Jaikumar, Sivakumar; Hipps, John; Lee, Yueh Z

    2015-01-01

    We report the neuroimaging and histopathologic findings of a 12-year-old female patient with a disseminated oligodendroglial-like leptomeningeal tumor with anaplastic progression and presumed extraneural metastatic disease. These tumors may represent distinct pathology primarily seen in pediatric patients. Neuroimaging demonstrates diffuse, progressive enhancement of the leptomeninges often with interval development of intraparenchymal lesions on follow-up. Disease is typically confined to the central nervous system, though diffuse peritoneal disease was seen in our case, possibly through metastatic seeding of the abdomen via ventriculoperitoneal shunt.

  10. Antioxidant enzymes in oligodendroglial brain tumors: association with proliferation, apoptotic activity and survival.

    PubMed

    Järvelä, Sally; Sally, Järvelä; Bragge, Helena; Helena, Bragge; Paunu, Niina; Niina, Paunu; Järvelä, Timo; Timo, Järvelä; Paljärvi, Leo; Leo, Paljärvi; Kalimo, Hannu; Hannu, Kalimo; Helén, Pauli; Pauli, Helén; Kinnula, Vuokko; Vuokko, Kinnula; Soini, Ylermi; Ylermi, Soini; Haapasalo, Hannu; Hannu, Haapasalo

    2006-04-01

    Purpose of the study was to investigate the relationship between antioxidant enzyme expression and clinicopathological features in oligodendroglial tumors. The expression of antioxidant enzymes and related proteins (AOEs), manganese superoxide dismutase (MnSOD), thioredoxin (Trx), thioredoxin reductase (TrxR) and gammaglutamylcysteine synthetase catalytic and regulatory subunits (GLCL-C and GLCL-R), was studied in 85 oligodendroglial tumors. The material included 71 primary (43 grade II and 28 grade III) and 14 recurrent (6 grade II and 8 grade III) tumors. Fifty-seven cases were pure oligodendrogliomas and 28 were mixed oligoastrocytomas. Immunoreactivity for MnSOD was found in 89%, Trx in 29%, TrxR in 76%, GLCL-C in 70% and GLCL-R in 68% of cases. Increased Trx expression was associated with higher tumor grade, cell proliferation and apoptosis (P=0.006, P=0.001 and P=0.003, Mann-Whitney test). Pure oligodendrogliomas showed more intense staining than oligoastrocytomas, especially for MnSOD (P=0.002, Mann-Whitney test). In the total series Trx was associated with poor prognosis in univariate survival analysis (P=0.0343, log-rank test) and furthermore in Cox multivariate analysis (P=0.009) along with age (P=0.002). The results suggest that the expression of Trx has a correlation to patient outcome and that there may be some association between AOEs, like MnSOD and Trx, and clinicopathological features of oligodendrogliomas.

  11. Characterization of Oligodendroglial Populations in Mouse Demyelinating Disease Using Flow Cytometry: Clues for MS Pathogenesis

    PubMed Central

    Goings, Gwendolyn E.; Miller, Stephen D.

    2014-01-01

    Characterizing and enumerating cells of the oligodendrocyte lineage (OLCs) is crucial for understanding demyelination and therapeutic benefit in models of demyelinating disease in the central nervous system. Here we describe a novel method for the rapid, unbiased analysis of mouse OLCs using flow cytometry. The assay was optimized to maximize viable yield of OLCs and maintain OLC antigen integrity. Panels of antibodies were assembled for simultaneous analysis of seven antigens on individual cells allowing for characterization of oligodendroglial cells throughout the lineage. We verified the utility of the assay with cultured OLCs and through a time course of developmental myelination. Next we employed the assay to characterize OLC populations in two well-characterized models of demyelination: cuprizone-induced demyelination and experimental autoimmune encephalomyelitis (EAE). In EAE we observed a dramatic loss of mature oligodendrocytes coincident with a dramatic expansion of oligodendrocyte progenitors cells (OPCs) at the onset of disease suggesting an attempt of the host to repair myelin. This expanded OPC pool was maintained through remission and relapse suggesting an arrest in differentiation in the face of the chronic autoimmune T cell-mediated inflammatory response. These robust, reproducible changes in OLCs through disease provide a rapid quantitative global analysis of myelin-producing cells in the adult mouse brain and important information regarding effects of disease on oligodendroglial proliferation/differentiation which is useful for defining the pathogenesis and therapy of MS. PMID:25247590

  12. Oligodendroglial maldevelopment in the cerebellum after postnatal hyperoxia and its prevention by minocycline

    PubMed Central

    Scheuer, Till; Brockmöller, Vivien; Knowlton, Marissa Blanco; Weitkamp, Jörn-Hendrik; Ruhwedel, Torben; Mueller, Susanne; Endesfelder, Stefanie; Bührer, Christoph; Schmitz, Thomas

    2015-01-01

    According to recent research, brain injury after premature birth often includes impaired growth of the cerebellum. However, causes of cerebellar injury in this population are poorly understood. In this study, we analyzed whether postnatal hyperoxia perturbs white matter development of the cerebellum, and whether cerebellar glial damage can be prevented by minocycline. We used a hyperoxia model in neonatal rats providing 24h exposure to 4-fold increased oxygen concentration (80% O2) from P6 to P7, followed by recovery in room air until P9, P11, P15, P30. Injections with minocycline were performed at the beginning and 12h into hyperoxia exposure. Hyperoxia induced oxidative stress in the cerebellum at P7 as evidenced by increased nitrotyrosine concentrations. Numbers of proliferating, NG2+Ki67+ oligodendroglial precursor cells were decreased at P7 after hyperoxia and at P11 following recovery in room air. Numbers of mature, CC1+ oligodendrocytes were diminished in recovering hyperoxia rats, and MBP expression was still decreased at P30. Electron microscopy analysis of myelinated fibers at P30 revealed thinner myelin sheath after hyperoxia. Long-term injury of the cerebellum by neonatal hyperoxia was confirmed by reduced volumes in MRI measurements at P30. In response to 80% O2, expression of PDGF-A was largely reduced in cerebellar tissue and also in cultured cerebellar astrocytes. Treatment with minocycline during hyperoxia prevented oxidative stress, attenuated oligodendroglial injury, and improved astroglial PDGF-A levels. In conclusion, early hyperoxia causes white matter damage in the cerebellum with astroglial dysfunction being involved, and both can be prevented by treatment with minocycline. PMID:25964099

  13. Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy

    PubMed Central

    2012-01-01

    Background The intracellular deposition of misfolded proteins is a common neuropathological hallmark of most neurodegenerative disorders. Increasing evidence suggests that these pathogenic proteins may spread to neighboring cells and induce the propagation of neurodegeneration. Results In this study, we have demonstrated that α-synuclein (αSYN), a major constituent of intracellular inclusions in synucleinopathies, was taken up by neuronal and oligodendroglial cells in both a time- and concentration-dependent manner. Once incorporated, the extracellular αSYN was immediately assembled into high-molecular-weight oligomers and subsequently formed cytoplasmic inclusion bodies. Furthermore, αSYN uptake by neurons and cells of the oligodendroglial lineage was markedly decreased by the genetic suppression and pharmacological inhibition of the dynamin GTPases, suggesting the involvement of the endocytic pathway in this process. Conclusions Our findings shed light on the mode of αSYN uptake by neuronal and oligodendroglial cells and identify therapeutic strategies aimed at reducing the propagation of protein misfolding. PMID:22892036

  14. Revisiting adult neurogenesis and the role of erythropoietin for neuronal and oligodendroglial differentiation in the hippocampus.

    PubMed

    Hassouna, I; Ott, C; Wüstefeld, L; Offen, N; Neher, R A; Mitkovski, M; Winkler, D; Sperling, S; Fries, L; Goebbels, S; Vreja, I C; Hagemeyer, N; Dittrich, M; Rossetti, M F; Kröhnert, K; Hannke, K; Boretius, S; Zeug, A; Höschen, C; Dandekar, T; Dere, E; Neher, E; Rizzoli, S O; Nave, K-A; Sirén, A-L; Ehrenreich, H

    2016-12-01

    Recombinant human erythropoietin (EPO) improves cognitive performance in neuropsychiatric diseases ranging from schizophrenia and multiple sclerosis to major depression and bipolar disease. This consistent EPO effect on cognition is independent of its role in hematopoiesis. The cellular mechanisms of action in brain, however, have remained unclear. Here we studied healthy young mice and observed that 3-week EPO administration was associated with an increased number of pyramidal neurons and oligodendrocytes in the hippocampus of ~20%. Under constant cognitive challenge, neuron numbers remained elevated until >6 months of age. Surprisingly, this increase occurred in absence of altered cell proliferation or apoptosis. After feeding a (15)N-leucine diet, we used nanoscopic secondary ion mass spectrometry, and found that in EPO-treated mice, an equivalent number of neurons was defined by elevated (15)N-leucine incorporation. In EPO-treated NG2-Cre-ERT2 mice, we confirmed enhanced differentiation of preexisting oligodendrocyte precursors in the absence of elevated DNA synthesis. A corresponding analysis of the neuronal lineage awaits the identification of suitable neuronal markers. In cultured neurospheres, EPO reduced Sox9 and stimulated miR124, associated with advanced neuronal differentiation. We are discussing a resulting working model in which EPO drives the differentiation of non-dividing precursors in both (NG2+) oligodendroglial and neuronal lineages. As endogenous EPO expression is induced by brain injury, such a mechanism of adult neurogenesis may be relevant for central nervous system regeneration.

  15. Transcriptomic regulations in oligodendroglial and microglial cells related to brain damage following fetal growth restriction.

    PubMed

    Rideau Batista Novais, Aline; Pham, Hoa; Van de Looij, Yohan; Bernal, Miguel; Mairesse, Jerome; Zana-Taieb, Elodie; Colella, Marina; Jarreau, Pierre-Henri; Pansiot, Julien; Dumont, Florent; Sizonenko, Stéphane; Gressens, Pierre; Charriaut-Marlangue, Christiane; Tanter, Mickael; Demene, Charlie; Vaiman, Daniel; Baud, Olivier

    2016-12-01

    Fetal growth restriction (FGR) is a major complication of human pregnancy, frequently resulting from placental vascular diseases and prenatal malnutrition, and is associated with adverse neurocognitive outcomes throughout life. However, the mechanisms linking poor fetal growth and neurocognitive impairment are unclear. Here, we aimed to correlate changes in gene expression induced by FGR in rats and abnormal cerebral white matter maturation, brain microstructure, and cortical connectivity in vivo. We investigated a model of FGR induced by low-protein-diet malnutrition between embryonic day 0 and birth using an interdisciplinary approach combining advanced brain imaging, in vivo connectivity, microarray analysis of sorted oligodendroglial and microglial cells and histology. We show that myelination and brain function are both significantly altered in our model of FGR. These alterations, detected first in the white matter on magnetic resonance imaging significantly reduced cortical connectivity as assessed by ultrafast ultrasound imaging. Fetal growth retardation was found associated with white matter dysmaturation as shown by the immunohistochemical profiles and microarrays analyses. Strikingly, transcriptomic and gene network analyses reveal not only a myelination deficit in growth-restricted pups, but also the extensive deregulation of genes controlling neuroinflammation and the cell cycle in both oligodendrocytes and microglia. Our findings shed new light on the cellular and gene regulatory mechanisms mediating brain structural and functional defects in malnutrition-induced FGR, and suggest, for the first time, a neuroinflammatory basis for the poor neurocognitive outcome observed in growth-restricted human infants. GLIA 2016;64:2306-2320.

  16. Immunomodulation by Transplanted Human Embryonic Stem Cell-Derived Oligodendroglial Progenitors in Experimental Autoimmune Encephalomyelitis

    PubMed Central

    Kim, Heechul; Walczak, Piotr; Kerr, Candace; Galpoththawela, Chulani; Gilad, Assaf A.; Muja, Naser; Bulte, Jeff W.M.

    2013-01-01

    Transplantation of embryonic stem cells and their neural derivatives can lead to amelioration of the disease symptoms of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis (MS). Oligodendroglial progenitors (OPs), derived from human embryonic stem cells (hESC, HES-1), were labeled with superparamagnetic iron oxide and transduced with luciferase. At 7 days following induction of EAE in C57/BL6 mice, 1 × 106 cells were transplanted in the ventricles of C57/BL6 mice and noninvasively monitored by magnetic resonance and bioluminescence imaging. Cells were found to remain within the cerebroventricular system and did not survive for more than 10 days. However, EAE mice that received hESC-OPs showed a significant improvement in neurological disability scores (0.9 ± 0.2; n = 12) compared to that of control animals (3.3 ± 0.4; n = 12) at day 15 post-transplantation. Histopathologically, transplanted hESC-OPs generated TREM2-positive CD45 cells, increased TIMP-1 expression, confined inflammatory cells within the subarachnoid space, and gave rise to higher numbers of Foxp3-positive regulatory T cells in the spinal cord and spleen. Our results suggest that transplantation of hESC-OPs can alter the pathogenesis of EAE through immunomodulation, potentially providing new avenues for stem cell-based treatment of MS. PMID:22949039

  17. Oxygen impairs oligodendroglial development via oxidative stress and reduced expression of HIF-1α

    PubMed Central

    Brill, Christina; Scheuer, Till; Bührer, Christoph; Endesfelder, Stefanie; Schmitz, Thomas

    2017-01-01

    The premature increase of oxygen tension may contribute to oligodendroglial precursor cell (OPC) damage in preterm infants. Fetal OPCs are exposed to low oxygen tissue tensions not matched when cells are cultured in room air. Maturation (A2B5, O4, O1, MBP, CNP, arborization), oxidative stress (nitrotyrosine Western blot, NRF2 and SOD2 expression), apoptosis (TUNEL), proliferation (Ki67), and expression of transcription factors regulated by Hypoxia-Inducible-Factor-1-alpha (Hif-1α) expressed in OPCs (Olig1, Olig2, Sox9, Sox10) were assessed in rat OPCs and OLN93 cells cultured at 5% O2 and 21% O2. Influences of Hif-1α were investigated by Hif-1α luciferase reporter assays and Hif-1α-knockdown experiments. At 21% O2, cell proliferation was decreased and process arborization of OPCs was reduced. Expression of MBP, CNP, Olig1, Sox9 and Sox10 was lower at 21% O2, while Nrf2, SOD2, nitrotyrosine were increased. Apoptosis was unchanged. Luciferease reporter assay in OLN93 cells indicated increased Hif-1α activity at 5% O2. In OLN93 cells at 5% O2, Hif-1α knockdown decreased the expression of MBP and CNP, similar to that observed at 21% O2. These data indicate that culturing OPCs at 21% O2 negatively affects development and maturation. Both enhanced oxidative stress and reduced expression of Hif-1α-regulated genes contribute to these hyperoxia-induced changes. PMID:28230075

  18. Revisiting adult neurogenesis and the role of erythropoietin for neuronal and oligodendroglial differentiation in the hippocampus

    PubMed Central

    Hassouna, I; Ott, C; Wüstefeld, L; Offen, N; Neher, R A; Mitkovski, M; Winkler, D; Sperling, S; Fries, L; Goebbels, S; Vreja, I C; Hagemeyer, N; Dittrich, M; Rossetti, M F; Kröhnert, K; Hannke, K; Boretius, S; Zeug, A; Höschen, C; Dandekar, T; Dere, E; Neher, E; Rizzoli, S O; Nave, K-A; Sirén, A-L; Ehrenreich, H

    2016-01-01

    Recombinant human erythropoietin (EPO) improves cognitive performance in neuropsychiatric diseases ranging from schizophrenia and multiple sclerosis to major depression and bipolar disease. This consistent EPO effect on cognition is independent of its role in hematopoiesis. The cellular mechanisms of action in brain, however, have remained unclear. Here we studied healthy young mice and observed that 3-week EPO administration was associated with an increased number of pyramidal neurons and oligodendrocytes in the hippocampus of ~20%. Under constant cognitive challenge, neuron numbers remained elevated until >6 months of age. Surprisingly, this increase occurred in absence of altered cell proliferation or apoptosis. After feeding a 15N-leucine diet, we used nanoscopic secondary ion mass spectrometry, and found that in EPO-treated mice, an equivalent number of neurons was defined by elevated 15N-leucine incorporation. In EPO-treated NG2-Cre-ERT2 mice, we confirmed enhanced differentiation of preexisting oligodendrocyte precursors in the absence of elevated DNA synthesis. A corresponding analysis of the neuronal lineage awaits the identification of suitable neuronal markers. In cultured neurospheres, EPO reduced Sox9 and stimulated miR124, associated with advanced neuronal differentiation. We are discussing a resulting working model in which EPO drives the differentiation of non-dividing precursors in both (NG2+) oligodendroglial and neuronal lineages. As endogenous EPO expression is induced by brain injury, such a mechanism of adult neurogenesis may be relevant for central nervous system regeneration. PMID:26809838

  19. Oligodendroglial alpha-synucleinopathy and MSA-like cardiovascular autonomic failure: experimental evidence.

    PubMed

    Kuzdas, Daniela; Stemberger, Sylvia; Gaburro, Stefano; Stefanova, Nadia; Singewald, Nicolas; Wenning, Gregor K

    2013-09-01

    Multiple system atrophy (MSA) is a fatal, rapidly progressive neurodegenerative disease with limited symptomatic treatment options. Discrimination of MSA from other degenerative disorders crucially depends on the presence of early and severe cardiovascular autonomic failure (CAF). We have previously shown that neuropathologic lesions in the central autonomic nuclei similar to the human disease are present in transgenic MSA mice generated by targeted oligodendroglial overexpression of α-syn using the PLP promoter. We here explore whether such lesions result in abnormalities of heart rate variability (HRV) and circadian rhythmicity which are typically impaired in MSA patients. HRV analysis was performed in five month old transgenic PLP-α-syn (tg) MSA mice and age-matched wild type controls. Decreased HRV and alterations in the circadian rhythmicity were detected in the tg MSA group. The number of choline-acetyltransferase-immunoreactive neurons in the nucleus ambiguus was significantly decreased in the tg group, whereas the levels of arginine-vasopressin neurons in the suprachiasmatic and paraventricular nucleus were not affected. Our finding of impaired HRV and circadian rhythmicity in tg MSA mice associated with degeneration of the nucleus ambiguus suggests that a cardinal non-motor feature of human MSA can be reproduced in the mouse model strengthening its role as a valuable testbed for studying selective vulnerability and assessing translational therapies.

  20. Automated Analysis of 1p/19q Status by FISH in Oligodendroglial Tumors: Rationale and Proposal of an Algorithm

    PubMed Central

    Duval, Céline; de Tayrac, Marie; Michaud, Karine; Cabillic, Florian; Paquet, Claudie; Gould, Peter Vincent; Saikali, Stéphan

    2015-01-01

    Objective To propose a new algorithm facilitating automated analysis of 1p and 19q status by FISH technique in oligodendroglial tumors with software packages available in the majority of institutions using this technique. Methods We documented all green/red (G/R) probe signal combinations in a retrospective series of 53 oligodendroglial tumors according to literature guidelines (Algorithm 1) and selected only the most significant combinations for a new algorithm (Algorithm 2). This second algorithm was then validated on a prospective internal series of 45 oligodendroglial tumors and on an external series of 36 gliomas. Results Algorithm 2 utilizes 24 G/R combinations which represent less than 40% of combinations observed with Algorithm 1. The new algorithm excludes some common G/R combinations (1/1, 3/2) and redefines the place of others (defining 1/2 as compatible with normal and 3/3, 4/4 and 5/5 as compatible with imbalanced chromosomal status). The new algorithm uses the combination + ratio method of signal probe analysis to give the best concordance between manual and automated analysis on samples of 100 tumor cells (91% concordance for 1p and 89% concordance for 19q) and full concordance on samples of 200 tumor cells. This highlights the value of automated analysis as a means to identify cases in which a larger number of tumor cells should be studied by manual analysis. Validation of this algorithm on a second series from another institution showed a satisfactory concordance (89%, κ = 0.8). Conclusion Our algorithm can be easily implemented on all existing FISH analysis software platforms and should facilitate multicentric evaluation and standardization of 1p/19q assessment in gliomas with reduction of the professional and technical time required. PMID:26135922

  1. Oligodendroglial Alterations and the Role of Microglia in White Matter Injury: Relevance to Schizophrenia

    PubMed Central

    Chew, Li-Jin; Fusar-Poli, Paolo; Schmitz, Thomas

    2015-01-01

    , recapitulating structural and functional characteristics observed in schizophrenia. In addition, elevated expression of inflammation-related genes in brain tissue and increased production of cytokines by blood cells from patients with schizophrenia indicate immunological dysfunction and abnormal inflammatory responses, which are also important underlying features in experimental models. Microglia, resident immune defenders of the central nervous system, play important roles in the development and protection of neural cells, but can contribute to injury under pathological conditions. This article discusses oligodendroglial changes in schizophrenia and focuses on microglial activity in the context of the disease, in neonatal brain injury and in various experimental models of white matter damage. These include disorders associated with premature birth, and animal models of perinatal bacterial and viral infection, oxygen deprivation (hypoxia) and excess (hyperoxia), and elevated systemic proinflammatory cytokine levels. We briefly review the effects of treatment with antipsychotic and anti-inflammatory agents in models of perinatal brain injury, and comment on the therapeutic potential of these strategies. By understanding the neurobiological basis of oligodendroglial abnormalities in schizophrenia, it is hoped that patients will benefit from the availability of targeted and more efficacious treatment options. PMID:23446060

  2. International retrospective study of over 1000 adults with anaplastic oligodendroglial tumors.

    PubMed

    Lassman, Andrew B; Iwamoto, Fabio M; Cloughesy, Timothy F; Aldape, Kenneth D; Rivera, Andreana L; Eichler, April F; Louis, David N; Paleologos, Nina A; Fisher, Barbara J; Ashby, Lynn S; Cairncross, J Gregory; Roldán, Gloria B; Wen, Patrick Y; Ligon, Keith L; Schiff, David; Robins, H Ian; Rocque, Brandon G; Chamberlain, Marc C; Mason, Warren P; Weaver, Susan A; Green, Richard M; Kamar, Francois G; Abrey, Lauren E; DeAngelis, Lisa M; Jhanwar, Suresh C; Rosenblum, Marc K; Panageas, Katherine S

    2011-06-01

    Treatment for newly diagnosed anaplastic oligodendroglial tumors is controversial. Radiotherapy (RT) alone and in combination with chemotherapy (CT) are the most well studied strategies. However, CT alone is often advocated, especially in cases with 1p19q codeletion. We retrospectively identified 1013 adults diagnosed from 1981-2007 treated initially with RT alone (n = 200), CT + RT (n = 528), CT alone (n = 201), or other strategies (n = 84). Median overall survival (OS) was 6.3 years and time to progression (TTP) was 3.1 years. 1p19q codeletion correlated with longer OS and TTP than no 1p or 19q deletion. In codeleted cases, median TTP was longer following CT + RT (7.2 y) than following CT (3.9 y, P = .003) or RT (2.5 y, P < .001) alone but without improved OS; median TTP was longer following treatment with PCV alone than temozolomide alone (7.6 vs. 3.3 y, P = .019). In cases with no deletion, median TTP was longer following CT + RT (3.1 y) than CT (0.9 y, P = .0124) or RT (1.1 y, P < .0001) alone; OS also favored CT + RT (median 5.0 y) over CT (2.2 y, P = .02) or RT (1.9 y, P < .0001) alone. In codeleted cases, CT alone did not appear to shorten OS in comparison with CT + RT, and PCV appeared to offer longer disease control than temozolomide but without a clear survival advantage. Combined CT + RT led to longer disease control and survival than did CT or RT alone in cases with no 1p19q deletion. Ongoing trials will address these issues prospectively.

  3. Topographical effects on fiber-mediated microRNA delivery to control oligodendroglial precursor cells development.

    PubMed

    Diao, Hua Jia; Low, Wei Ching; Lu, Q Richard; Chew, Sing Yian

    2015-11-01

    Effective remyelination in the central nervous system (CNS) facilitates the reversal of disability in patients with demyelinating diseases such as multiple sclerosis. Unfortunately until now, effective strategies of controlling oligodendrocyte (OL) differentiation and maturation remain limited. It is well known that topographical and biochemical signals play crucial roles in modulating cell fate commitment. Therefore, in this study, we explored the combined effects of scaffold topography and sustained gene silencing on oligodendroglial precursor cell (OPC) development. Specifically, microRNAs (miRs) were incorporated onto electrospun polycaprolactone (PCL) fiber scaffolds with different fiber diameters and orientations. Regardless of fiber diameter and orientation, efficient knockdown of differentiation inhibitory factors were achieved by either topography alone (up to 70%) or fibers integrated with miR-219 and miR-338 (up to 80%, p < 0.05). Small fiber promoted OPC differentiation by inducing more RIP(+) cells (p < 0.05) while large fiber promoted OL maturation by inducing more MBP(+) cells (p < 0.05). Random fiber enhanced more RIP(+) cells than aligned fibers (p < 0.05), regardless of fiber diameter. Upon miR-219/miR-338 incorporation, 2 μm aligned fibers supported the most MBP(+) cells (∼17%). These findings indicated that the coupling of substrate topographic cues with efficient gene silencing by sustained microRNA delivery is a promising way for directing OPC maturation in neural tissue engineering and controlling remyelination in the CNS.

  4. Cerebral ischemia or intrauterine inflammation promotes differentiation of oligodendroglial precursors in preterm ovine fetuses: possible cellular basis for white matter injury.

    PubMed

    Kitanishi, Ryuta; Matsuda, Tadashi; Watanabe, Shinpei; Saito, Masatoshi; Hanita, Takushi; Watanabe, Tatsuya; Kobayashi, Yoshiyasu

    2014-01-01

    White matter injury in premature infants is known to be major cause of long-term neurocognitive disability, but the pathogenic mechanism remains unclear, hampering our ability to develop preventions. Periventricular leukomalacia is a severe form of white matter injury. In the present study, we explored the effects of cerebral ischemia and/or intrauterine inflammation on the development of oligodendroglia in the cerebral white matter using chronically instrumented fetal sheep. Each fetus received one of three insults: hemorrhage, inflammation and their combination. In the hemorrhage group, 40% of the fetoplacental blood volume was acutely withdrawn, and 24 hours after removal, the blood was returned to the fetus. The inflammation group received intravenous granulocyte-colony stimulating factor and intra-amniotic endotoxin and thus suffered from necrotizing funisitis and chorioamnionitis. The inflammatory hemorrhage group underwent acute hemorrhage under the inflammatory state. The sham group received no insults. Importantly, periventricular leukomalacia was not detected in the sham and the inflammation groups. Differentiating oligodendroglia at various developmental stages were identified by immunohistochemical analysis with specific antibodies. No difference in the density of oligodendroglial progenitors was detected among the four groups, whereas oligodendroglial precursors were significantly reduced in the three insult groups, compared to sham control. Moreover, the density of immature oligodendroglia was higher in the inflammation group and the inflammatory hemorrhage group, while the density of mature oligodendroglia was highest in the hemorrhage group. We propose that cerebral ischemia or intrauterine inflammation induces the differentiation of oligodendroglial precursors in preterm fetuses, eventually resulting in their exhaustion.

  5. MiR-125a-3p timely inhibits oligodendroglial maturation and is pathologically up-regulated in human multiple sclerosis

    PubMed Central

    Lecca, Davide; Marangon, Davide; Coppolino, Giusy T.; Méndez, Aida Menéndez; Finardi, Annamaria; Costa, Gloria Dalla; Martinelli, Vittorio; Furlan, Roberto; Abbracchio, Maria P.

    2016-01-01

    In the mature central nervous system (CNS), oligodendrocytes provide support and insulation to axons thanks to the production of a myelin sheath. During their maturation to myelinating cells, oligodendroglial precursors (OPCs) follow a very precise differentiation program, which is finely orchestrated by transcription factors, epigenetic factors and microRNAs (miRNAs), a class of small non-coding RNAs involved in post-transcriptional regulation. Any alterations in this program can potentially contribute to dysregulated myelination, impaired remyelination and neurodegenerative conditions, as it happens in multiple sclerosis (MS). Here, we identify miR-125a-3p, a developmentally regulated miRNA, as a new actor of oligodendroglial maturation, that, in the mammalian CNS regulates the expression of myelin genes by simultaneously acting on several of its already validated targets. In cultured OPCs, over-expression of miR-125a-3p by mimic treatment impairs while its inhibition with an antago-miR stimulates oligodendroglial maturation. Moreover, we show that miR-125a-3p levels are abnormally high in the cerebrospinal fluid of MS patients bearing active demyelinating lesions, suggesting that its pathological upregulation may contribute to MS development, at least in part by blockade of OPC differentiation leading to impaired repair of demyelinated lesions. PMID:27698367

  6. NCAM1 is the Target of miRNA-572: Validation in the Human Oligodendroglial Cell Line.

    PubMed

    Mancuso, Roberta; Agostini, Simone; Marventano, Ivana; Hernis, Ambra; Saresella, Marina; Clerici, Mario

    2017-03-22

    The neural cell adhesion molecule 1 (NCAM1) is a fundamental protein in cell-cell interaction and in cellular developmental processes, and its dysregulation is involved in a number of diseases including multiple sclerosis. Studies in rats suggest that the modulation of NCAM1 expression is regulated by miRNA-572, but no data are available confirming such interaction in the human system. We analyzed whether this is the case using a human oligodendroglial cell line (MO3.13). MO3.13 cells were transfected with miRNA-572 mimic and inhibitor separately; NCAM1 mRNA and protein expression levels were analyzed at different time points after transfection. Results indicated that NCAM1 expression is increased after transfection with miRNA-572 inhibitor, whereas it is decreased after transfection with the mimic (p < 0.005). The interaction between NCAM1 and miRNA-572 was subsequently confirmed in a Vero cell line that does not express NCAM1, by luciferase assay after transfection with NCAM1. These results confirm that miRNA-572 regulates NCAM1 and for the first time demonstrate that this interaction regulates NCAM1 expression in human cells. Data herein also support the hypothesis that miRNA-572 is involved in diseases associated with NCAM1 deregulation, suggesting its possible use as a biomarker in these diseases.

  7. Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival.

    PubMed

    Jaillard, C; Harrison, S; Stankoff, B; Aigrot, M S; Calver, A R; Duddy, G; Walsh, F S; Pangalos, M N; Arimura, N; Kaibuchi, K; Zalc, B; Lubetzki, C

    2005-02-09

    Endothelial differentiation gene (Edg) proteins are G-protein-coupled receptors activated by lysophospholipid mediators: sphingosine-1-phosphate (S1P) or lysophosphatidic acid. We show that in the CNS, expression of Edg8/S1P5, a high-affinity S1P receptor, is restricted to oligodendrocytes and expressed throughout development from the immature stages to the mature myelin-forming cell. S1P activation of Edg8/S1P5 on O4-positive pre-oligodendrocytes induced process retraction via a Rho kinase/collapsin response-mediated protein signaling pathway, whereas no retraction was elicited by S1P on these cells derived from Edg8/S1P5-deficient mice. Edg8/S1P5-mediated process retraction was restricted to immature cells and was no longer observed at later developmental stages. In contrast, S1P activation promoted the survival of mature oligodendrocytes but not of pre-oligodendrocytes. The S1P-induced survival of mature oligodendrocytes was mediated through a pertussis toxin-sensitive, Akt-dependent pathway. Our data demonstrate that Edg8/S1P5 activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival and that these effects depend on the developmental stage of the cell.

  8. Differential expression of L- and S-MAG upon cAMP stimulated differentiation in oligodendroglial cells.

    PubMed

    Erb, M; Steck, A J; Nave, K A; Schaeren-Wiemers, N

    2003-02-01

    Myelin-associated glycoprotein (MAG), an immunoglobulin-like cell signaling protein involved in axon-glial interactions, displays two intracellular C-termini as a result of alternative mRNA splicing. During brain development, the two MAG mRNAs that encode L-MAG and S-MAG differ in their relative abundance. We have investigated the differential expression of L- and S-MAG upon cAMP treatment in the oligodendroglial cell line Oli-neu, a cell line able to differentiate in vitro. We have engineered GFP and VSVG fusions by small insertions into the alternatively spliced exons of the cloned MAG gene and reintroduced them into Oli-neu cells. The individually tagged MAG isoforms were expressed under the control of the MAG promoter and regulatory region. In this system, L-MAG was the predominant isoform before the stimulation of cells with cAMP, whereas upon cAMP treatment the S-MAG isoform was predominantly expressed in cells with a high degree of morphological differentiation. We suggest that the regulation of the MAG alternative splicing and the morphological differentiation in oligodendrocytes are controlled both by the same cAMP-responsive differentiation step.

  9. Disseminated oligodendroglial-like leptomeningeal tumors: preliminary diagnostic and therapeutic results for a novel tumor entity [corrected].

    PubMed

    Preuss, Matthias; Christiansen, Holger; Merkenschlager, Andreas; Hirsch, Franz Wolfgang; Kiess, Wieland; Müller, Wolf; Kästner, Stefanie; Henssler, Andreas; Pekrun, Arnulf; Hauch, Holger; Nathrath, Michaela; Meixensberger, Jürgen; Pietsch, Torsten; Kuchelmeister, Klaus

    2015-08-01

    Pediatric tumors of the central nervous system composed of oligoid tumor cells showing diffuse leptomeningeal spread without a primary mass lesion seem to represent a novel tumor entity. The terms "diffuse leptomeningeal glioneural tumor" or-preferably-"disseminated oligodendroglial-like leptomeningeal tumor of childhood" (DOGLT) were proposed. Four patients were identified with clinico-neuropathologic findings compatible with DOGLT and a mean follow-up time of 54 months was determined. Seven different biopsies obtained from the four patients were histologically evaluated. Clinical course, diagnostic measures, histopathologic and radiologic features and treatment suggestions were recorded, on the basis of which diagnostic and therapeutic algorithm was proposed. Patients with DOGLT presented with hydrocephalus as first symptom, requiring neurosurgical therapy. Open arachnoid biopsy was necessary to confirm diagnosis. The oligoid cells in a desmoplastic or focally myxoid matrix showed OLIG2-, MAP2-, S-100 and rare HuC/HuD protein-immunopositivity. IDH1 (R132H)- and CD99-immunohistochemistry was negative in all patients. None of the evaluable biopsies of three patients showed chromosome 1p/19q deletion, neither as isolated nor combined allelic loss. Chemotherapy according to the SIOP-LGG 2004 standard induction and consolidation protocol resulted in complete response and partial response, respectively, in 50 % of the patients. However, after discontinuation of chemotherapy, two patients experienced tumor progression and one of them succumbed to the disease after 19 months. Radiological criteria as well as preliminary treatment results are presented after observation of four clinical cases. Prognosis and long-term clinical courses remain to be observed.

  10. Codeletion of 1p and 19q determines distinct gene methylation and expression profiles in IDH-mutated oligodendroglial tumors.

    PubMed

    Mur, Pilar; Mollejo, Manuela; Ruano, Yolanda; de Lope, Ángel Rodríguez; Fiaño, Concepción; García, Juan Fernando; Castresana, Javier S; Hernández-Laín, Aurelio; Rey, Juan A; Meléndez, Bárbara

    2013-08-01

    Oligodendroglial tumors (OTs) are primary brain tumors that show variable clinical and biological behavior. The 1p/19q codeletion is frequent in these tumors, indicating a better prognosis and/or treatment response. Recently, the prognostically favorable CpG island methylator phenotype (CIMP) in gliomas (G-CIMP+) was associated with mutations in the isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 (IDH) genes, as opposed to G-CIMP- tumors, highlighting the relevance of epigenetic mechanisms. We performed a whole-genome methylation study in 46 OTs, and a gene expression study of 25 tumors, correlating the methylation and transcriptomic profiles with molecular and clinical variables. Here, we identified two different epigenetic patterns within the previously described main G-CIMP+ profile. Both IDH mutation-associated methylation profiles featured one group of OTs with 1p/19q loss (CD-CIMP+), most of which were pure oligodendrogliomas, and a second group with intact 1p/19q and frequent TP53 mutation (CIMP+), most of which exhibited a mixed histopathology. A third group of OTs lacking the CIMP profile (CIMP-), and with a wild-type IDH and an intact 1p/19q, similar to the G-CIMP- subgroup, was also observed. The three CIMP groups presented a significantly better (CD-CIMP+), intermediate (CIMP+) or worse (CIMP-) prognosis. Furthermore, transcriptomic analyses revealed CIMP-specific gene expression signatures, indicating the impact of genetic status (IDH mutation, 1p/19q codeletion, TP53 mutation) on gene expression, and pointing to candidate biomarkers. Therefore, the CIMP profiles contributed to the identification of subgroups of OTs characterized by different prognoses, histopathologies, molecular features and gene expression signatures, which may help in the classification of OTs.

  11. Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis.

    PubMed

    Höftberger, Romana; Fink, Stephanie; Aboul-Enein, Fahmy; Botond, Gergö; Olah, Judit; Berki, Timea; Ovadi, Judit; Lassmann, Hans; Budka, Herbert; Kovacs, Gabor G

    2010-11-15

    Multiple sclerosis (MS) is an idiopathic chronic inflammatory demyelinating disease of the central nervous system with variable extent of remyelination. Remyelination originates from oligodendrocyte (OG) precursor cells, which migrate and differentiate into mature OG. Tubulin polymerization promoting protein (TPPP/p25) is located in mature OG and aggregates in oligodendroglial cytoplasmic inclusions in multiple system atrophy. We developed a novel monoclonal anti-TPPP/p25 antibody to quantify OG in different subtypes and disease stages of MS, and possible degenerative changes in OG. We evaluated autopsy material from 25 MS cases, including acute, primary progressive, secondary progressive, relapsing remitting MS, and five controls. Demyelinated lesions revealed loss of TPPP/p25-positive OG within the plaques. In remyelination, TPPP/p25 was first expressed in OG cytoplasms and later became positive in myelin sheaths. We observed increased numbers of TPPP/p25 immunoreactive OG in the normal appearing white matter (NAWM) in MS patients. In MS cases, the cytoplasmic area of TPPP/p25 immunoreactivity in the OG was higher in the periplaque area when compared with NAWM and the plaque, and TPPP/p25 immunoreactive OG cytoplasmic area inversely correlated with the disease duration. There was a lack of phospho-TDP-43, phospho-tau, α-synuclein, and ubiquitin immunoreactivity in OG with enlarged cytoplasm. Our data suggest impaired differentiation, migration, and activation capacity of OG in later disease stages of MS. Upregulation of TPPP/p25 in the periplaque white matter OG without evidence for inclusion body formation might reflect an activation state. Distinct and increased expression of TPPP/p25 in MS renders it a potential prognostic and diagnostic marker of MS.

  12. Tumor necrosis factor-α impairs oligodendroglial differentiation through a mitochondria-dependent process

    PubMed Central

    Bonora, M; De Marchi, E; Patergnani, S; Suski, J M; Celsi, F; Bononi, A; Giorgi, C; Marchi, S; Rimessi, A; Duszyński, J; Pozzan, T; Wieckowski, M R; Pinton, P

    2014-01-01

    Mitochondrial defects, affecting parameters such as mitochondrial number and shape, levels of respiratory chain complex components and markers of oxidative stress, have been associated with the appearance and progression of multiple sclerosis. Nevertheless, mitochondrial physiology has never been monitored during oligodendrocyte progenitor cell (OPC) differentiation, especially in OPCs challenged with proinflammatory cytokines. Here, we show that tumor necrosis factor alpha (TNF-α) inhibits OPC differentiation, accompanied by altered mitochondrial calcium uptake, mitochondrial membrane potential, and respiratory complex I activity as well as increased reactive oxygen species production. Treatment with a mitochondrial uncoupler (FCCP) to mimic mitochondrial impairment also causes cells to accumulate at the progenitor stage. Interestingly, AMP-activated protein kinase (AMPK) levels increase during TNF-α exposure and inhibit OPC differentiation. Overall, our data indicate that TNF-α induces metabolic changes, driven by mitochondrial impairment and AMPK activation, leading to the inhibition of OPC differentiation. PMID:24658399

  13. Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination

    PubMed Central

    Madsen, Pernille M.; Motti, Dario; Karmally, Shaffiat; Szymkowski, David E.; Lambertsen, Kate Lykke; Bethea, John R.

    2016-01-01

    Tumor necrosis factor (TNF) is associated with the pathophysiology of various neurological disorders, including multiple sclerosis. It exists as a transmembrane form tmTNF, signaling via TNF receptor 2 (TNFR2) and TNFR1, and a soluble form, solTNF, signaling via TNFR1. Multiple sclerosis is associated with the detrimental effects of solTNF acting through TNFR1, while tmTNF promotes repair and remyelination. Here we demonstrate that oligodendroglial TNFR2 is a key mediator of tmTNF-dependent protection in experimental autoimmune encephalomyelitis (EAE). CNP-cre:TNFR2fl/fl mice with TNFR2 ablation in oligodendrocytes show exacerbation of the disease with increased axon and myelin pathology, reduced remyelination, and increased loss of oligodendrocyte precursor cells and mature oligodendrocytes. The clinical course of EAE is not improved by the solTNF inhibitor XPro1595 in CNP-cre:TNFR2fl/fl mice, indicating that for tmTNF to promote recovery TNFR2 in oligodendrocytes is required. We show that TNFR2 drives differentiation of oligodendrocyte precursor cells, but not proliferation or survival. TNFR2 ablation leads to dysregulated expression of microRNAs, among which are regulators of oligodendrocyte differentiation and inflammation, including miR-7a. Our data provide the first direct in vivo evidence that TNFR2 in oligodendrocytes is important for oligodendrocyte differentiation, thereby sustaining tmTNF-dependent repair in neuroimmune disease. Our studies identify TNFR2 in the CNS as a molecular target for the development of remyelinating agents, addressing the most pressing need in multiple sclerosis therapy nowadays. SIGNIFICANCE STATEMENT Our study, using novel TNF receptor 2 (TNFR2) conditional KO mice with selective TNFR2 ablation in oligodendrocytes, provides the first direct evidence that TNFR2 is an important signal for oligodendrocyte differentiation. Following activation by transmembrane TNF, TNFR2 initiates pathways that drive oligodendrocytes into a

  14. Contribution of 1p, 19q, 9p and 10q Automated Analysis by FISH to the Diagnosis and Prognosis of Oligodendroglial Tumors According to WHO 2016 Guidelines

    PubMed Central

    Michaud, Karine; de Tayrac, Marie; D’Astous, Myreille; Duval, Céline; Paquet, Claudie; Samassekou, Oumar; Gould, Peter Vincent; Saikali, Stéphan

    2016-01-01

    Objective To study the feasibility and the diagnostic and prognostic interest of automated analysis of 1p, 19q, 9p and 10q status by FISH technique in oligodendroglial tumors. Methods We analyzed a retrospective series of 33 consecutive gliomas with oligodendroglial histology (originally diagnosed as 24 oligodendrogliomas and 9 oligoastrocytomas). For all cases, automated FISH analysis of 1p, 19q, 9p and 10q status were performed and compared to clinical and histological data, ATRX, IDH1R132H and alpha-internexin status (studied by immunohistochemistry) and overall survival (OS). Manual analysis of 9p and 10q status were also performed and compared to automated analysis to verify the concordance of the two methods. Results The 33 gliomas were reclassified into 13 low-grade oligodendrogliomas (OII), 10 anaplastic oligodendrogliomas (OIII), 3 diffuse astrocytomas (AII), 3 anaplastic astrocytomas (AIII) and 4 glioblastomas (GBM) according to the WHO 2016 histological criteria. The 1p and/or 19q imbalanced status were restricted to astrocytomas with no correlation to their grade or their OS. Chromosome 9p deletion was restricted to OIII (70%) and GBM (100%) and was correlated with a shorter OS in the total cohort (p = 0.0007), the oligodendroglioma cohort (p = 0.03) and the astrocytoma cohort (p = 0.001). Concordance between 9p manual and automated analysis was satisfactory (81%, κ = 0.69). Chromosome 10q deletion was restricted to GBMs (50%) and was correlated with a poor OS in both the total cohort (p = 0.003) and the astrocytoma (AS) cohort (p = 0.04). Concordance between manual and automated analysis was satisfactory (79%, κ = 0.62). Conclusion Automated analysis of 1p, 19q, 9p and 10q status by FISH is a reliable technique which allows for refined classification of oligodendroglial tumors. 1p and/or 19q imbalanced status is evidence of astrocytic differentiation. 9p deletion is found in high grade oligodendrogliomas and astrocytomas with a poor OS. 10q is

  15. Effects of iron chelators, iron salts, and iron oxide nanoparticles on the proliferation and the iron content of oligodendroglial OLN-93 cells.

    PubMed

    Hohnholt, Michaela; Geppert, Mark; Dringen, Ralf

    2010-08-01

    The oligodendroglial cell line OLN-93 was used as model system to investigate the consequences of iron deprivation or iron excess on cell proliferation. Presence of ferric or ferrous iron chelators inhibited the proliferation of OLN-93 cells in a time and concentration dependent manner, while the application of a molar excess of ferric ammonium citrate (FAC) prevented the inhibition of proliferation by the chelator deferoxamine. Proliferation of OLN-93 cells was not affected by incubation with 300 microM iron that was applied in the form of FAC, FeCl(2), ferrous ammonium sulfate or iron oxide nanoparticles, although the cells efficiently accumulated iron during exposure to each of these iron sources. The highest specific iron content was observed for cells that were exposed to the nanoparticles. These data demonstrate that the proliferation of OLN-93 cells depends strongly on the availability of iron and that these cells efficiently accumulate iron from various extracellular iron sources.

  16. Inhibition of UCH-L1 in oligodendroglial cells results in microtubule stabilization and prevents α-synuclein aggregate formation by activating the autophagic pathway: implications for multiple system atrophy

    PubMed Central

    Pukaß, Katharina; Richter-Landsberg, Christiane

    2015-01-01

    α-Synuclein (α-syn) positive glial cytoplasmic inclusions (GCI) originating in oligodendrocytes (ODC) are a characteristic hallmark in multiple system atrophy (MSA). Their occurrence may be linked to a failure of the ubiquitin proteasome system (UPS) or the autophagic pathway. For proteasomal degradation, proteins need to be covalently modified by ubiquitin, and deubiquitinated by deubiquitinating enzymes (DUBs) before proteolytic degradation is performed. The DUB ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) is a component of the UPS, it is abundantly expressed in neuronal brain cells and has been connected to Parkinson’s disease (PD). It interacts with α-syn and tubulin. The present study was undertaken to investigate whether UCH-L1 is a constituent of ODC, the myelin forming cells of the CNS, and is associated with GCIs in MSA. Furthermore, LDN-57444 (LDN), a specific UCH-L1 inhibitor, was used to analyze its effects on cell morphology, microtubule (MT) organization and the proteolytic degradation system. Towards this an oligodendroglial cell line (OLN cells), stably transfected with α-syn or with α-syn and GFP-LC3, to monitor the autophagic flux, was used. The data show that UCH-L1 is expressed in ODC derived from the brains of newborn rats and colocalizes with α-syn in GCIs of MSA brain sections. LDN treatment had a direct impact on the MT network by affecting tubulin posttranslational modifications, i.e., acetylation and tyrosination. An increase in α-tubulin detyrosination was observed and detyrosinated MT were abundantly recruited to the cellular extensions. Furthermore, small α-syn aggregates, which are constitutively expressed in OLN cells overexpressing α-syn, were abolished, and LDN caused the upregulation of the autophagic pathway. Our data add to the knowledge that the UPS and the autophagy-lysosomal pathway are tightly balanced, and that UCH-L1 and its regulation may play a role in neurodegenerative diseases with oligodendroglia

  17. Iron-dependent formation of reactive oxygen species and glutathione depletion after accumulation of magnetic iron oxide nanoparticles by oligodendroglial cells

    NASA Astrophysics Data System (ADS)

    Hohnholt, Michaela C.; Dringen, Ralf

    2011-12-01

    Magnetic iron oxide nanoparticles (IONP) are currently used for various neurobiological applications. To investigate the consequences of a treatment of brain cells with such particles, we have applied dimercaptosuccinate (DMSA)-coated IONP that had an average hydrodynamic diameter of 60 nm to oligodendroglial OLN-93 cells. After exposure to 4 mM iron applied as DMSA-IONP, these cells increased their total specific iron content within 8 h 600-fold from 7 to 4,200 nmol/mg cellular protein. The strong iron accumulation was accompanied by a change in cell morphology, although the cell viability was not compromized. DMSA-IONP treatment caused a concentration-dependent increase in the iron-dependent formation of reactive oxygen species and a decrease in the specific content of the cellular antioxidative tripeptide glutathione. During a 16 h recovery phase in IONP-free culture medium following exposure to DMSA-IONP, OLN-93 cells maintained their high iron content and replenished their cellular glutathione content. These data demonstrate that viable OLN-93 cells have a remarkable potential to deal successfully with the consequences of an accumulation of large amounts of iron after exposure to DMSA-IONP.

  18. Deferred radiotherapy and upfront procarbazine–ACNU–vincristine administration for 1p19q codeleted oligodendroglial tumors are associated with favorable outcome without compromising patient performance, regardless of WHO grade

    PubMed Central

    Hata, Nobuhiro; Yoshimoto, Koji; Hatae, Ryusuke; Kuga, Daisuke; Akagi, Yojiro; Suzuki, Satoshi O; Iwaki, Toru; Shono, Tadahisa; Mizoguchi, Masahiro; Iihara, Koji

    2016-01-01

    Recently updated phase III trials revealed the favorable effect of add-on procarbazine-lomustine-vincristine chemotherapy (CT) to radiotherapy (RT) in treating anaplastic oligodendrogliomas with 1p19q codeletion (codel). However, the underlying rationality of deferring RT and upfront CT administration for these tumors is yet to be elucidated. Here, we retrospectively analyzed the long-term outcome of our case series with oligodendroglial tumors treated with deferred RT and upfront procarbazine+nimustine+vincristine (PAV) in the introduction administration. We enrolled 36 patients with newly diagnosed oligodendroglial tumors (17, grade II and 19, grade III) treated during 1999–2012 and followed up for a median period of 69.0 months. Their clinical and genetic prognostic factors were analyzed, and progression-free survival, overall survival (OS), and deterioration-free survival (DFS) were evaluated. Regardless of the WHO grade, the 25 patients with 1p19q codel tumors never received RT initially, and of these 25, 23 received PAV treatment upfront. The 75% OS of patients with 1p19q codel tumor was 135.3 months (did not reach the median OS), indicating a favorable outcome. Multivariate analysis revealed that IDH mutation and 1p19q, not WHO grade, are independent prognostic factors; furthermore, IDH and 1p19q status stratified the cohort into 3 groups with significantly different OS. The DFS explained the prolonged survival without declining performance in patients with both grade II and III 1p19q codel tumors. Deferred RT and upfront PAV treatment for 1p19q codel oligodendrogliomas were associated with favorable outcomes without compromising performance status, regardless of WHO grade. PMID:27895504

  19. Brain components

    MedlinePlus Videos and Cool Tools

    The brain is composed of more than a thousand billion neurons. Specific groups of them, working in concert, provide ... of information. The 3 major components of the brain are the cerebrum, cerebellum, and brain stem. The ...

  20. Battery component

    SciTech Connect

    Goebel, F.; Batson, D.C.; Miserendino, A.J.; Boyle, G.

    1988-03-15

    A mechanical component for reserve type electrochemical batteries having cylindrical porous members is described comprising a disc having: (i) circular grooves in one flat side for accepting the porous members; and (ii) at least one radial channel in the opposite flat side in fluid communication with the grooves.

  1. Robotic component preparation

    SciTech Connect

    Dokos, J.R.

    1986-04-01

    This report provides information on the preparation of robotic components. Component preparation includes pretinning or solder dipping, preforming, and pretrimming of component leads. Since about 70% of all components are axial-leaded resistor-type components, it was decided to begin with them and then later develop capabilities to handle other types. The first workcell is the first phase of an overall system to pretin, preform, and pretrim all components and to feed them to an automatic insertion system. Before use of the robot, a Unimation PUMA Modal 260, pretinning and preforming was done by first hand with a shield and vented booth.

  2. Software component quality evaluation

    NASA Technical Reports Server (NTRS)

    Clough, A. J.

    1991-01-01

    The paper describes a software inspection process that can be used to evaluate the quality of software components. Quality criteria, process application, independent testing of the process and proposed associated tool support are covered. Early results indicate that this technique is well suited for assessing software component quality in a standardized fashion. With automated machine assistance to facilitate both the evaluation and selection of software components, such a technique should promote effective reuse of software components.

  3. Reactor component automatic grapple

    DOEpatents

    Greenaway, Paul R.

    1982-01-01

    A grapple for handling nuclear reactor components in a medium such as liquid sodium which, upon proper seating and alignment of the grapple with the component as sensed by a mechanical logic integral to the grapple, automatically seizes the component. The mechanical logic system also precludes seizure in the absence of proper seating and alignment.

  4. Psychological Component of Infertility

    MedlinePlus

    ... Home FAQs Frequently Asked Questions Quick Facts About Infertility FAQs About Infertility FAQs About the Psychological Component of Infertility FAQs About Cloning and Stem Cell Research SART's ...

  5. Generalized Structured Component Analysis

    ERIC Educational Resources Information Center

    Hwang, Heungsun; Takane, Yoshio

    2004-01-01

    We propose an alternative method to partial least squares for path analysis with components, called generalized structured component analysis. The proposed method replaces factors by exact linear combinations of observed variables. It employs a well-defined least squares criterion to estimate model parameters. As a result, the proposed method…

  6. The elusive third component

    NASA Astrophysics Data System (ADS)

    Meyers, J. F.

    The historical development of techniques for measuring three velocity components using laser velocimetry is presented. The techniques are described and their relative merits presented. Many of the approaches currently in use based on the fringe laser velocimeter have yielded inaccurate measurements of turbulence intensity in the on-axis component. A possible explanation for these inaccuracies is presented along with simulation results.

  7. The Elusive Third Component

    NASA Technical Reports Server (NTRS)

    Meyers, James F.

    2004-01-01

    The historical development of techniques for measuring three velocity components using laser velocimetry is presented. The techniques are described and their relative merits presented. Many of the approaches currently in use based on the fringe laser velocimeter have yielded inaccurate measurements of turbulence intensity in the on-axis component. A possible explanation for these inaccuracies is presented along with simulation results.

  8. Design of Critical Components

    NASA Technical Reports Server (NTRS)

    Hendricks, Robert C.; Zaretsky, Erwin V.

    2001-01-01

    Critical component design is based on minimizing product failures that results in loss of life. Potential catastrophic failures are reduced to secondary failures where components removed for cause or operating time in the system. Issues of liability and cost of component removal become of paramount importance. Deterministic design with factors of safety and probabilistic design address but lack the essential characteristics for the design of critical components. In deterministic design and fabrication there are heuristic rules and safety factors developed over time for large sets of structural/material components. These factors did not come without cost. Many designs failed and many rules (codes) have standing committees to oversee their proper usage and enforcement. In probabilistic design, not only are failures a given, the failures are calculated; an element of risk is assumed based on empirical failure data for large classes of component operations. Failure of a class of components can be predicted, yet one can not predict when a specific component will fail. The analogy is to the life insurance industry where very careful statistics are book-kept on classes of individuals. For a specific class, life span can be predicted within statistical limits, yet life-span of a specific element of that class can not be predicted.

  9. GCS component development cycle

    NASA Astrophysics Data System (ADS)

    Rodríguez, Jose A.; Macias, Rosa; Molgo, Jordi; Guerra, Dailos; Pi, Marti

    2012-09-01

    The GTC1 is an optical-infrared 10-meter segmented mirror telescope at the ORM observatory in Canary Islands (Spain). First light was at 13/07/2007 and since them it is in the operation phase. The GTC control system (GCS) is a distributed object & component oriented system based on RT-CORBA8 and it is responsible for the management and operation of the telescope, including its instrumentation. GCS has used the Rational Unified process (RUP9) in its development. RUP is an iterative software development process framework. After analysing (use cases) and designing (UML10) any of GCS subsystems, an initial component description of its interface is obtained and from that information a component specification is written. In order to improve the code productivity, GCS has adopted the code generation to transform this component specification into the skeleton of component classes based on a software framework, called Device Component Framework. Using the GCS development tools, based on javadoc and gcc, in only one step, the component is generated, compiled and deployed to be tested for the first time through our GUI inspector. The main advantages of this approach are the following: It reduces the learning curve of new developers and the development error rate, allows a systematic use of design patterns in the development and software reuse, speeds up the deliverables of the software product and massively increase the timescale, design consistency and design quality, and eliminates the future refactoring process required for the code.

  10. Scientific Software Component Technology

    SciTech Connect

    Kohn, S.; Dykman, N.; Kumfert, G.; Smolinski, B.

    2000-02-16

    We are developing new software component technology for high-performance parallel scientific computing to address issues of complexity, re-use, and interoperability for laboratory software. Component technology enables cross-project code re-use, reduces software development costs, and provides additional simulation capabilities for massively parallel laboratory application codes. The success of our approach will be measured by its impact on DOE mathematical and scientific software efforts. Thus, we are collaborating closely with library developers and application scientists in the Common Component Architecture forum, the Equation Solver Interface forum, and other DOE mathematical software groups to gather requirements, write and adopt a variety of design specifications, and develop demonstration projects to validate our approach. Numerical simulation is essential to the science mission at the laboratory. However, it is becoming increasingly difficult to manage the complexity of modern simulation software. Computational scientists develop complex, three-dimensional, massively parallel, full-physics simulations that require the integration of diverse software packages written by outside development teams. Currently, the integration of a new software package, such as a new linear solver library, can require several months of effort. Current industry component technologies such as CORBA, JavaBeans, and COM have all been used successfully in the business domain to reduce software development costs and increase software quality. However, these existing industry component infrastructures will not scale to support massively parallel applications in science and engineering. In particular, they do not address issues related to high-performance parallel computing on ASCI-class machines, such as fast in-process connections between components, language interoperability for scientific languages such as Fortran, parallel data redistribution between components, and massively

  11. Component-specific modeling

    NASA Technical Reports Server (NTRS)

    Mcknight, R. L.

    1985-01-01

    Accomplishments are described for the second year effort of a 3-year program to develop methodology for component specific modeling of aircraft engine hot section components (turbine blades, turbine vanes, and burner liners). These accomplishments include: (1) engine thermodynamic and mission models; (2) geometry model generators; (3) remeshing; (4) specialty 3-D inelastic stuctural analysis; (5) computationally efficient solvers, (6) adaptive solution strategies; (7) engine performance parameters/component response variables decomposition and synthesis; (8) integrated software architecture and development, and (9) validation cases for software developed.

  12. Ceramic component for electrodes

    DOEpatents

    Marchant, David D.

    1979-01-01

    A ceramic component suitable for preparing MHD generator electrodes consists of HfO.sub.2 and sufficient Tb.sub.4 O.sub.7 to stabilize at least 60 volume percent of the HfO.sub.2 into the cubic structure. The ceramic component may also contain a small amount of PrO.sub.2, Yb.sub.2 O.sub.3 or a mixture of both to improve stability and electronic conductivity of the electrode. The component is highly resistant to corrosion by molten potassium seed and molten coal slag in the MHD fluid and exhibits both ionic and electronic conductivity.

  13. Evaluating Performance of Components

    NASA Technical Reports Server (NTRS)

    Katz, Daniel; Tisdale, Edwin; Norton, Charles

    2004-01-01

    Parallel Component Performance Benchmarks is a computer program developed to aid the evaluation of the Common Component Architecture (CCA) - a software architecture, based on a component model, that was conceived to foster high-performance computing, including parallel computing. More specifically, this program compares the performances (principally by measuring computing times) of componentized versus conventional versions of the Parallel Pyramid 2D Adaptive Mesh Refinement library - a software library that is used to generate computational meshes for solving physical problems and that is typical of software libraries in use at NASA s Jet Propulsion Laboratory.

  14. Structural materials and components

    NASA Technical Reports Server (NTRS)

    Gagliani, John (Inventor); Lee, Raymond (Inventor)

    1982-01-01

    High density structural (blocking) materials composed of a polyimide filled with glass microballoons. Structural components such as panels which have integral edgings and/or other parts made of the high density materials.

  15. Structural materials and components

    NASA Technical Reports Server (NTRS)

    Gagliani, John (Inventor); Lee, Raymond (Inventor)

    1982-01-01

    High density structural (blocking) materials composed of a polyimide filled with glass microballoons and methods for making such materials. Structural components such as panels which have integral edgings and/or other parts made of the high density materials.

  16. Structural materials and components

    NASA Technical Reports Server (NTRS)

    Gagliani, John (Inventor); Lee, Raymond (Inventor)

    1983-01-01

    High density structural (blocking) materials composed of a polyimide filled with glass microballoons. Structural components such as panels which have integral edgings and/or other parts made of the high density materials.

  17. Component Fixturing Method

    NASA Technical Reports Server (NTRS)

    Kling, Daniel (Inventor)

    2014-01-01

    An end-configuration of components to be moved or positioned is first obtained. This end-configuration determines the relative positioning and orientation of the components with respect to each other when in a final, desired configuration. A folding pattern is then obtained that is formed by interior vertices defining corresponding tessellation facets. The folding pattern can be induced to transition from a first folded configuration to a second folded configuration. When in the second folded configuration mounting facets, which are a subset of the tessellation facets, are arranged by the geometry of the folding pattern into positions and orientations with respect to each other that correspond to the end-configuration of the components. A foldable structure is then obtained that folds in accordance with the folding pattern, and the components are affixed to their respective mounting facets.

  18. Develop a Model Component

    NASA Technical Reports Server (NTRS)

    Ensey, Tyler S.

    2013-01-01

    During my internship at NASA, I was a model developer for Ground Support Equipment (GSE). The purpose of a model developer is to develop and unit test model component libraries (fluid, electrical, gas, etc.). The models are designed to simulate software for GSE (Ground Special Power, Crew Access Arm, Cryo, Fire and Leak Detection System, Environmental Control System (ECS), etc. .) before they are implemented into hardware. These models support verifying local control and remote software for End-Item Software Under Test (SUT). The model simulates the physical behavior (function, state, limits and 110) of each end-item and it's dependencies as defined in the Subsystem Interface Table, Software Requirements & Design Specification (SRDS), Ground Integrated Schematic (GIS), and System Mechanical Schematic.(SMS). The software of each specific model component is simulated through MATLAB's Simulink program. The intensiv model development life cycle is a.s follows: Identify source documents; identify model scope; update schedule; preliminary design review; develop model requirements; update model.. scope; update schedule; detailed design review; create/modify library component; implement library components reference; implement subsystem components; develop a test script; run the test script; develop users guide; send model out for peer review; the model is sent out for verifictionlvalidation; if there is empirical data, a validation data package is generated; if there is not empirical data, a verification package is generated; the test results are then reviewed; and finally, the user. requests accreditation, and a statement of accreditation is prepared. Once each component model is reviewed and approved, they are intertwined together into one integrated model. This integrated model is then tested itself, through a test script and autotest, so that it can be concluded that all models work conjointly, for a single purpose. The component I was assigned, specifically, was a

  19. Encyclopedia of software components

    NASA Technical Reports Server (NTRS)

    Vanwarren, Lloyd (Inventor); Beckman, Brian C. (Inventor)

    1991-01-01

    Intelligent browsing through a collection of reusable software components is facilitated with a computer having a video monitor and a user input interface such as a keyboard or a mouse for transmitting user selections, by presenting a picture of encyclopedia volumes with respective visible labels referring to types of software, in accordance with a metaphor in which each volume includes a page having a list of general topics under the software type of the volume and pages having lists of software components for each one of the generic topics, altering the picture to open one of the volumes in response to an initial user selection specifying the one volume to display on the monitor a picture of the page thereof having the list of general topics and altering the picture to display the page thereof having a list of software components under one of the general topics in response to a next user selection specifying the one general topic, and then presenting a picture of a set of different informative plates depicting different types of information about one of the software components in response to a further user selection specifying the one component.

  20. Encyclopedia of Software Components

    NASA Technical Reports Server (NTRS)

    Warren, Lloyd V. (Inventor); Beckman, Brian C. (Inventor)

    1997-01-01

    Intelligent browsing through a collection of reusable software components is facilitated with a computer having a video monitor and a user input interface such as a keyboard or a mouse for transmitting user selections, by presenting a picture of encyclopedia volumes with respective visible labels referring to types of software, in accordance with a metaphor in which each volume includes a page having a list of general topics under the software type of the volume and pages having lists of software components for each one of the generic topics, altering the picture to open one of the volumes in response to an initial user selection specifying the one volume to display on the monitor a picture of the page thereof having the list of general topics and altering the picture to display the page thereof having a list of software components under one of the general topics in response to a next user selection specifying the one general topic, and then presenting a picture of a set of different informative plates depicting different types of information about one of the software components in response to a further user selection specifying the one component.

  1. Scientific Component Technology Initiative

    SciTech Connect

    Kohn, S; Bosl, B; Dahlgren, T; Kumfert, G; Smith, S

    2003-02-07

    The laboratory has invested a significant amount of resources towards the development of high-performance scientific simulation software, including numerical libraries, visualization, steering, software frameworks, and physics packages. Unfortunately, because this software was not designed for interoperability and re-use, it is often difficult to share these sophisticated software packages among applications due to differences in implementation language, programming style, or calling interfaces. This LDRD Strategic Initiative investigated and developed software component technology for high-performance parallel scientific computing to address problems of complexity, re-use, and interoperability for laboratory software. Component technology is an extension of scripting and object-oriented software development techniques that specifically focuses on the needs of software interoperability. Component approaches based on CORBA, COM, and Java technologies are widely used in industry; however, they do not support massively parallel applications in science and engineering. Our research focused on the unique requirements of scientific computing on ASCI-class machines, such as fast in-process connections among components, language interoperability for scientific languages, and data distribution support for massively parallel SPMD components.

  2. Ceramic component for electrodes

    DOEpatents

    Marchant, David D.; Bates, J. Lambert

    1980-01-01

    A ceramic component suitable for preparing MHD generator electrodes having the compositional formula: Y.sub.x (Mg.sub.y Cr.sub.z).sub.w Al.sub.(1-w) O.sub.3 where x=0.9 to 1.05, y=0.02 to 0.2, z=0.8 to 1.05 and w=1.0 to 0.5. The component is resistant to the formation of hydration products in an MHD environment, has good electrical conductivity and exhibits a lower electrochemical corrosion rate than do comparable compositions of lanthanum chromite.

  3. Component-specific modeling

    NASA Technical Reports Server (NTRS)

    Mcknight, R. L.

    1985-01-01

    A series of interdisciplinary modeling and analysis techniques that were specialized to address three specific hot section components are presented. These techniques will incorporate data as well as theoretical methods from many diverse areas including cycle and performance analysis, heat transfer analysis, linear and nonlinear stress analysis, and mission analysis. Building on the proven techniques already available in these fields, the new methods developed will be integrated into computer codes to provide an accurate, and unified approach to analyzing combustor burner liners, hollow air cooled turbine blades, and air cooled turbine vanes. For these components, the methods developed will predict temperature, deformation, stress and strain histories throughout a complete flight mission.

  4. Blood Component Therapy

    PubMed Central

    Kelton, J. G.

    1984-01-01

    Human blood has been transfused for about 60-70 years. Over this time, the practice of blood transfusion has changed dramatically. One major change is the separation of blood into its various components. As a result, the patient can receive only the blood component in which he is deficient. In this way, the risk of side effects—particularly hepatitis—is lessened. This article briefly reviews the various blood products, the indications for their use, and some associated risks. These products include oxygen-carrying products, plasma products, blood products used to correct hemostatic defects, and immune globulin. PMID:21279096

  5. Oligodendroglial proliferation in presymptomatic Huntington`s disease

    SciTech Connect

    Myers, R.H.; Friend, J.C.; Cupples, L.A.

    1994-09-01

    Morphometric studies of the tail of the caudate nucleus were performed on fourteen brain specimens collected from individuals at risk for inheriting HD. Medical records and information obtained from immediate family members indicated that all had died without symptoms of HD. Five of the 14 individuals had 37 or more CAG repeats, as determined by PCR quantification, and were designated HD gene carriers. Nine were determined to be non-carriers. Cell counts of the tail of the caudate nucleus revealed an increased density of oligodendrocytes among the presymptomatic HD gene carriers (carrier mean=41.5, non-carrier mean=20.7; age, sex, repeated measure adjusted F=8.36, p<0.02). While modest proliferation of oligodendrocytes had been reported in response to neurodegeneration, the doubling in density found here is not consistent with that noted in neurodegeneration. Furthermore, the numbers of neurons among the HD gene carriers was not reduced (mean neuron density: carriers = 16.0; non-carriers = 16.2) suggesting that there has been no appreciable neurodegeneration. No astrocyte (mean density: carriers = 25.0; non-carriers = 21.2; p=0.58) or microglial (mean density; carriers = 8.6; non-carriers = 6.1; p=0.21) differences were found. The area of cross-section of the tail of the caudate nucleus for four of the nine non-carriers was such that ten microscope fields could not be accommodated, whereas all of the HD gene carrier specimens could accommodate ten fields in cross-section. Thus the increased density was not a consequence of atrophy of the caudate nucleus among the gene carriers. Altered densitites may reflect developmental effects in HD gene carriers.

  6. TSC Regulates Oligodendroglial Differentiation and Myelination in the CNS

    DTIC Science & Technology

    2011-09-01

    10/1/05- present Professor and Rena Warshow Chair in Multiple Sclerosis , Department of Neurology and Neurosciences, New Jersey Medical School, UMDNJ...Receptor Function in Mammary Development, 09/30/07-07/31/12 National Multiple Sclerosis Society RG 4015A2/2 (Wood) The mTOR Pathway: A Master...MS PPO558 National Multiple Sclerosis Society Pilot Grant (Wood) CNTF Regulation of Peptide Growth Factors in Oligodendrocytes, 8/1/97-7/31/98

  7. Designing Cool Components

    NASA Technical Reports Server (NTRS)

    2000-01-01

    A NASA SBIR contract served as the beginning for the development of Daat Research Corporation's Coolit software. Coolit is a unique computational fluid dynamics (CFD) application aimed at thermal and cooling design problems. Coolit can generate 3-D representations of the thermofluid environment and "sketch" the component on the computer. The software modeling reduces time and effort in prototype building and testing.

  8. Component School Construction Program.

    ERIC Educational Resources Information Center

    New Brunswick Dept. of Economic Growth, Fredericton.

    In 1968, the Province of New Brunswick initiated a three-phase program to provide for elementary school facilities, employing a component systems approach to their construction. This booklet describes briefly the planning and construction of these schools, and provides graphic and photographic records of the construction in progress as well as of…

  9. Liquid rocket valve components

    NASA Technical Reports Server (NTRS)

    1973-01-01

    A monograph on valves for use with liquid rocket propellant engines is presented. The configurations of the various types of valves are described and illustrated. Design criteria and recommended practices for the various valves are explained. Tables of data are included to show the chief features of valve components in use on operational vehicles.

  10. Informed Test Component Weighting.

    ERIC Educational Resources Information Center

    Rudner, Lawrence M.

    2001-01-01

    Identifies and evaluates alternative methods for weighting tests. Presents formulas for composite reliability and validity as a function of component weights and suggests a rational process that identifies and considers trade-offs in determining weights. Discusses drawbacks to implicit weighting and explicit weighting and the difficulty of…

  11. Molecular Models Candy Components

    ERIC Educational Resources Information Center

    Coleman, William F.

    2007-01-01

    An explanation of various principles of chemistry in a paper by Fanny Ennever by the use of candy is described. The paper explains components of sucrose and the invert sugar that results from the hydrolysis of sucrose and will help students in determining whether the products are indeed hydrates of carbon.

  12. Revealing Optical Components

    NASA Technical Reports Server (NTRS)

    2002-01-01

    The Optical Vector Analyzer (OVA) 1550 significantly reduces the time and cost of testing sophisticated optical components. The technology grew from the research Luna Technologies' Dr. Mark Froggatt conducted on optical fiber strain measurement while working at Langley Research Center. Dr. Froggatt originally developed the technology for non- destructive evaluation testing at Langley. The new technique can provide 10,000 independent strain measurements while adding less than 10 grams to the weight of the vehicle. The OVA is capable of complete linear characterization of single-mode optical components used in high- bit-rate applications. The device can test most components over their full range in less than 30 seconds, compared to the more than 20 minutes required by other testing methods. The dramatically shortened measurement time results in increased efficiency in final acceptance tests of optical devices, and the comprehensive data produced by the instrument adds considerable value for component consumers. The device eliminates manufacturing bottlenecks, while reducing labor costs and wasted materials during production.

  13. Developing a Model Component

    NASA Technical Reports Server (NTRS)

    Fields, Christina M.

    2013-01-01

    The Spaceport Command and Control System (SCCS) Simulation Computer Software Configuration Item (CSCI) is responsible for providing simulations to support test and verification of SCCS hardware and software. The Universal Coolant Transporter System (UCTS) was a Space Shuttle Orbiter support piece of the Ground Servicing Equipment (GSE). The initial purpose of the UCTS was to provide two support services to the Space Shuttle Orbiter immediately after landing at the Shuttle Landing Facility. The UCTS is designed with the capability of servicing future space vehicles; including all Space Station Requirements necessary for the MPLM Modules. The Simulation uses GSE Models to stand in for the actual systems to support testing of SCCS systems during their development. As an intern at Kennedy Space Center (KSC), my assignment was to develop a model component for the UCTS. I was given a fluid component (dryer) to model in Simulink. I completed training for UNIX and Simulink. The dryer is a Catch All replaceable core type filter-dryer. The filter-dryer provides maximum protection for the thermostatic expansion valve and solenoid valve from dirt that may be in the system. The filter-dryer also protects the valves from freezing up. I researched fluid dynamics to understand the function of my component. The filter-dryer was modeled by determining affects it has on the pressure and velocity of the system. I used Bernoulli's Equation to calculate the pressure and velocity differential through the dryer. I created my filter-dryer model in Simulink and wrote the test script to test the component. I completed component testing and captured test data. The finalized model was sent for peer review for any improvements. I participated in Simulation meetings and was involved in the subsystem design process and team collaborations. I gained valuable work experience and insight into a career path as an engineer.

  14. Developing a Model Component

    NASA Technical Reports Server (NTRS)

    Fields, Christina M.

    2013-01-01

    The Spaceport Command and Control System (SCCS) Simulation Computer Software Configuration Item (CSCI) is,. responsible for providing simulations to support test and verification of SCCS hardware and software. The Universal Coolant Transporter System (UCTS) is a Space Shuttle Orbiter support piece of the Ground Servicing Equipment (GSE). The purpose of the UCTS is to provide two support services to the Space Shuttle Orbiter immediately after landing at the Shuttle Landing Facility. The Simulation uses GSE Models to stand in for the actual systems to support testing of SCCS systems s:luring their development. As an intern at KSC, my assignment was to develop a model component for the UCTS. I was given a fluid component (drier) to model in Matlab. The drier was a Catch All replaceable core type filter-drier. The filter-drier provides maximum protection for the thermostatic expansion valve and solenoid valve from dirt that may be in the system. The filter-drier also protects the valves from freezing up. I researched fluid dynamics to understand the function of my component. I completed training for UNIX and Simulink to help aid in my assignment. The filter-drier was modeled by determining affects it has on the pressure, velocity and temperature of the system. I used Bernoulli's Equation to calculate the pressure and velocity differential through the dryer. I created my model filter-drier in Simulink and wrote the test script to test the component. I completed component testing and captured test data. The finalized model was sent for peer review for any improvements.

  15. Component-specific modeling

    NASA Technical Reports Server (NTRS)

    Mcknight, R. L.

    1984-01-01

    A series of interdisciplinary modeling and analysis techniques that were specialized to address three specific hot section components are presented. These techniques will incorporate data as well as theoretical methods from many diverse areas including cycle and performance analysis, heat transfer analysis, linear and nonlinear stress analysis, and mission analysis. Building on the proven techniques already available in these fields, the new methods developed will be integrated into computer codes to provide an accurate, efficient and unified approach to analyzing combustor burner liners, hollow air-cooled turbine blades and air-cooled turbine vanes. For these components, the methods developed will predict temperature, deformation, stress and strain histories throughout a complete flight mission.

  16. Component specific modeling

    NASA Technical Reports Server (NTRS)

    Maffeo, R. J.; Mcknight, R. L.; Tipton, M. T.; Weber, G.

    1986-01-01

    The overall objective of this program is to develop and verify a series of interdisciplinary modeling and analysis techniques that were specialized to address three specific hot section components. These techniques incorporate data as well as theoretical methods from many diverse areas including cycle and performance analysis, heat transfer analysis, linear and nonlinear stress analysis, and mission analysis. Building on the proven techniques already available in these fields, the new methods developed are integrated to provide an accurate, efficient, and unified approach to analyzing combustor burner liners, hollow air-cooled turbine blades, and air-cooled turbine vanes. For these components, the methods developed predict temperature, deformation, stress, and strain histories throughout a complete flight mission.

  17. MEA Component Durability

    SciTech Connect

    Frisk, J. W.; Hicks, M.T.; Atanasoski, R. T.; Boand, W. M.; Schmoeckel, A. K.; Kurkowski, M. J.

    2004-11-01

    Membrane electrode assembly (MEA) lifetime of greater than 40,000 hours remains a goal of the fuel cell industry. However, there is a lack of fundamental understanding of the mechanisms of MEA degradation. Specifically, the relationship between component physical property changes and MEA performance decay has not been established. We report preliminary data relating changes in gas diffusion layer (GDL) physical properties to fuel cell performance decay.

  18. Components of laboratory accreditation.

    PubMed

    Royal, P D

    1995-12-01

    Accreditation or certification is a recognition given to an operation or product that has been evaluated against a standard; be it regulatory or voluntary. The purpose of accreditation is to provide the consumer with a level of confidence in the quality of operation (process) and the product of an organization. Environmental Protection Agency/OCM has proposed the development of an accreditation program under National Environmental Laboratory Accreditation Program for Good Laboratory Practice (GLP) laboratories as a supplement to the current program. This proposal was the result of the Inspector General Office reports that identified weaknesses in the current operation. Several accreditation programs can be evaluated and common components identified when proposing a structure for accrediting a GLP system. An understanding of these components is useful in building that structure. Internationally accepted accreditation programs provide a template for building a U.S. GLP accreditation program. This presentation will discuss the traditional structure of accreditation as presented in the Organization of Economic Cooperative Development/GLP program, ISO-9000 Accreditation and ISO/IEC Guide 25 Standard, and the Canadian Association for Environmental Analytical Laboratories, which has a biological component. Most accreditation programs are managed by a recognized third party, either privately or with government oversight. Common components often include a formal review of required credentials to evaluate organizational structure, a site visit to evaluate the facility, and a performance evaluation to assess technical competence. Laboratory performance is measured against written standards and scored. A formal report is then sent to the laboratory indicating accreditation status. Usually, there is a scheduled reevaluation built into the program. Fee structures vary considerably and will need to be examined closely when building a GLP program.

  19. Solid state lighting component

    SciTech Connect

    Yuan, Thomas; Keller, Bernd; Ibbetson, James; Tarsa, Eric; Negley, Gerald

    2010-10-26

    An LED component comprising an array of LED chips mounted on a planar surface of a submount with the LED chips capable of emitting light in response to an electrical signal. The LED chips comprise respective groups emitting at different colors of light, with each of the groups interconnected in a series circuit. A lens is included over the LED chips. Other embodiments can comprise thermal spreading structures included integral to the submount and arranged to dissipate heat from the LED chips.

  20. Solid state lighting component

    SciTech Connect

    Keller, Bernd; Ibbetson, James; Tarsa, Eric; Negley, Gerald; Yuan, Thomas

    2012-07-10

    An LED component comprising an array of LED chips mounted on a planar surface of a submount with the LED chips capable of emitting light in response to an electrical signal. The LED chips comprise respective groups emitting at different colors of light, with each of the groups interconnected in a series circuit. A lens is included over the LED chips. Other embodiments can comprise thermal spreading structures included integral to the submount and arranged to dissipate heat from the LED chips.

  1. Component for thermoelectric generator

    DOEpatents

    Purdy, David L.

    1977-01-01

    In a thermoelectric generator, a component comprises a ceramic insulator, having over limited areas thereof, each area corresponding to a terminal end of thermoelectric wires, a coating of a first metal which adheres to the insulator, and an electrical thermoelectric junction including a second metal which wets said first metal and adheres to said terminal ends but does not wet said insulator, and a cloth composed of electrically insulating threads interlaced with thermoelectric wires.

  2. Diffusion bonding aeroengine components

    NASA Astrophysics Data System (ADS)

    Fitzpatrick, G. A.; Broughton, T.

    1988-10-01

    The use of diffusion bonding processes at Rolls-Royce for the manufacture of titanium-alloy aircraft engine components and structures is described. A liquid-phase diffusion bonding process called activated diffusion bonding has been developed for the manufacture of the hollow titanium wide chord fan blade. In addition, solid-state diffusion bonding is being used in the manufacture of hollow vane/blade airfoil constructions mainly in conjunction with superplastic forming and hot forming techniques.

  3. Injection molded component

    SciTech Connect

    James, Allister W; Arrell, Douglas J

    2014-09-30

    An intermediate component includes a first wall member, a leachable material layer, and a precursor wall member. The first wall member has an outer surface and first connecting structure. The leachable material layer is provided on the first wall member outer surface. The precursor wall member is formed adjacent to the leachable material layer from a metal powder mixed with a binder material, and includes second connecting structure.

  4. Optimized Kernel Entropy Components.

    PubMed

    Izquierdo-Verdiguier, Emma; Laparra, Valero; Jenssen, Robert; Gomez-Chova, Luis; Camps-Valls, Gustau

    2016-02-25

    This brief addresses two main issues of the standard kernel entropy component analysis (KECA) algorithm: the optimization of the kernel decomposition and the optimization of the Gaussian kernel parameter. KECA roughly reduces to a sorting of the importance of kernel eigenvectors by entropy instead of variance, as in the kernel principal components analysis. In this brief, we propose an extension of the KECA method, named optimized KECA (OKECA), that directly extracts the optimal features retaining most of the data entropy by means of compacting the information in very few features (often in just one or two). The proposed method produces features which have higher expressive power. In particular, it is based on the independent component analysis framework, and introduces an extra rotation to the eigen decomposition, which is optimized via gradient-ascent search. This maximum entropy preservation suggests that OKECA features are more efficient than KECA features for density estimation. In addition, a critical issue in both the methods is the selection of the kernel parameter, since it critically affects the resulting performance. Here, we analyze the most common kernel length-scale selection criteria. The results of both the methods are illustrated in different synthetic and real problems. Results show that OKECA returns projections with more expressive power than KECA, the most successful rule for estimating the kernel parameter is based on maximum likelihood, and OKECA is more robust to the selection of the length-scale parameter in kernel density estimation.

  5. Artificial polarization components

    NASA Astrophysics Data System (ADS)

    Cescato, L.; Gluch, Ekkehard; Stork, Wilhelm; Streibl, Norbert

    1990-07-01

    High frequency surface relief structures are optically anisotropic and show interesting polarisation properties 1 . These properties can be used to produce polarizations components such as wave plates polarizers. polarizing beamsplitters etc. Our experimental results show that even gratings with relatively low spatial frequency ( periods A ) exhibit a strong phase retardation and can be used as quarter-wave plates. k INTRODUC11ON The artificial birefringence exhibited by ultrahigh frequency gratings of dielectric materials can be used to produce various polarization components2 . Such components have applications in integrated optics as well as in free space optics. In order to produce the high spatial frequencies complex processes such as electron-beam lithography and reactive ion etching are needed. We show in this paper that sinusoidal holographic gratings in photoresist exhibit also a strong phase ret even at relatively long periods. L EXPERIMENTAL MEASUREMENTS To obtain the phase retardation of a lower frequency ( period A ) grating a simple setup as used by Enger and 2 can be applied. In our case however there are three measurements necessary to obtain the phase retardation because transmission of the two perpendicularly polarized beams is different from each other. I GRATING PRODUCTION grating 2 3 4 5 6 7 8 9 period (pmj 0. 74 0. 74 0. 61 0. 54 0. 46 0. 32 0. 54 0. 54 0. 54 ne (sec) 60

  6. Surface mount component jig

    DOEpatents

    Kronberg, James W.

    1990-08-07

    A device for bending and trimming the pins of a dual-inline-package component and the like for surface mounting rather than through mounting to a circuit board comprises, in a first part, in pin cutter astride a holder having a recess for holding the component, a first spring therebetween, and, in a second part, two flat members pivotally interconnected by a hinge and urged to an upward peaked position from a downward peaked position by a second spring. As a downward force is applied to the pin cutter it urges the holder downward, assisted by the first spring and a pair of ridges riding on shoulders of the holder, to carry the component against the upward peaked flat members which guide the pins outwardly. As the holder continues downwardly, the flat members pivot to the downward peaked position bending the pins upwardly against the sides of the holder. When the downward movement is met with sufficient resistance, the ridges of the pin cutter ride over the holder's shoulders to continue downward to cut any excess length of pin.

  7. Energetic component treatability study

    SciTech Connect

    Gildea, P.D.; Brandon, S.L.; Brown, B.G.

    1997-11-01

    The effectiveness of three environmentally sound processes for small energetic component disposal was examined experimentally in this study. The three destruction methods, batch reactor supercritical water oxidation, sodium hydroxide base hydrolysis and calcium carbonate cookoff were selected based on their potential for producing a clean solid residue and minimum release of toxic gases after component detonation. The explosive hazard was destroyed by all three processes. Batch supercritical water oxidation destroyed both the energetics and organics. Further development is desired to optimize process parameters. Sodium hydroxide base hydrolysis and calcium carbonate cookoff results indicated the potential for scrubbing gaseous detonation products. Further study and testing are needed to quantify the effectiveness of these later two processes for full-scale munition destruction. The preliminary experiments completed in this study have demonstrated the promise of these three processes as environmentally sound technologies for energetic component destruction. Continuation of these experimental programs is strongly recommended to optimize batch supercritical water oxidation processing, and to fully develop the sodium hydroxide base hydrolysis and calcium carbonate cookoff technologies.

  8. Inkjet deposited circuit components

    NASA Astrophysics Data System (ADS)

    Bidoki, S. M.; Nouri, J.; Heidari, A. A.

    2010-05-01

    All-printed electronics as a means of achieving ultra-low-cost electronic circuits has attracted great interest in recent years. Inkjet printing is one of the most promising techniques by which the circuit components can be ultimately drawn (i.e. printed) onto the substrate in one step. Here, the inkjet printing technique was used to chemically deposit silver nanoparticles (10-200 nm) simply by ejection of silver nitrate and reducing solutions onto different substrates such as paper, PET plastic film and textile fabrics. The silver patterns were tested for their functionality to work as circuit components like conductor, resistor, capacitor and inductor. Different levels of conductivity were achieved simply by changing the printing sequence, inks ratio and concentration. The highest level of conductivity achieved by an office thermal inkjet printer (300 dpi) was 5.54 × 105 S m-1 on paper. Inkjet deposited capacitors could exhibit a capacitance of more than 1.5 nF (parallel plate 45 × 45 mm2) and induction coils displayed an inductance of around 400 µH (planar coil 10 cm in diameter). Comparison of electronic performance of inkjet deposited components to the performance of conventionally etched items makes the technique highly promising for fabricating different printed electronic devices.

  9. Recursive principal components analysis.

    PubMed

    Voegtlin, Thomas

    2005-10-01

    A recurrent linear network can be trained with Oja's constrained Hebbian learning rule. As a result, the network learns to represent the temporal context associated to its input sequence. The operation performed by the network is a generalization of Principal Components Analysis (PCA) to time-series, called Recursive PCA. The representations learned by the network are adapted to the temporal statistics of the input. Moreover, sequences stored in the network may be retrieved explicitly, in the reverse order of presentation, thus providing a straight-forward neural implementation of a logical stack.

  10. Analysis Components Investigation Report

    DTIC Science & Technology

    2014-10-01

    rebuildin in the vicin the school. ation of N t allow the ment of In est" can be med intere nts from a , this comp ervices wh ion of NLP rest (as w cify...releva ch as possi ecialize in ion of NLP ranking) on uses Alfre t allows m will be used e that offer sis compon the terms i rns the te ument Freq...order in ponent con nts in orde ASSIFIED December 2 LOSED TO ANY P onent performed is process sis task per ts, or a sele e Solution document ion of NLP t

  11. Components of Verbal Intelligence.

    DTIC Science & Technology

    1985-12-30

    is permitted for any purpose of the United States Government. 9 This research Was sponsored by the Personnel and Training Research Programs...FUNDING NUMBERS PROGRAM PROJECT TASK UNit ELEMENT NO NO NO IACCESSION NO 11. TITLE (Irclude Secu, l Olassfication) NR154-505 "Components of Verbal...a_ _ A , , . Z I l-l S"" -- ’s= -:s~ l - + 6 ’ E =:,. E cEIP d -= 5.,. ’-E ; Ea ,3 8.9.1 -=,o pr ,,v c+ -- + + - , ? + -+ + a; 0 1;- I " ’N Ev E.~4

  12. Advanced Power Electronics Components

    NASA Technical Reports Server (NTRS)

    Schwarze, Gene E.

    2004-01-01

    This paper will give a description and status of the Advanced Power Electronics Materials and Components Technology program being conducted by the NASA Glenn Research Center for future aerospace power applications. The focus of this research program is on the following: 1) New and/or significantly improved dielectric materials for the development of power capacitors with increased volumetric efficiency, energy density, and operating temperature. Materials being investigated include nanocrystalline and composite ceramic dielectrics and diamond-like carbon films; 2) New and/or significantly improved high frequency, high temperature, low loss soft magnetic materials for the development of transformers/inductors with increased power/energy density, electrical efficiency, and operating temperature. Materials being investigated include nanocrystalline and nanocomposite soft magnetic materials; 3) Packaged high temperature, high power density, high voltage, and low loss SiC diodes and switches. Development of high quality 4H- and 6H- SiC atomically smooth substrates to significantly improve device performance is a major emphasis of the SiC materials program; 4) Demonstration of high temperature (> 200 C) circuits using the components developed above.

  13. Laser generating metallic components

    NASA Astrophysics Data System (ADS)

    McLean, Marc A.; Shannon, G. J.; Steen, William M.

    1997-04-01

    Recent developments in rapid prototyping have led to the concept of laser generating, the first additive manufacturing technology. This paper presents an innovative process of depositing multi-layer tracks, by fusing successive powder tracks, to generate three dimensional components, thereby offering an alternative to casting for small metal component manufacture. A coaxial nozzle assembly has been designed and manufactured enabling consistent omni-directional multi-layer deposition. In conjunction with this the software route from a CAD drawing to machine code generation has been established. The part is manufactured on a six axes machining center incorporating a 1.8 kW carbon-dioxide laser, providing an integrated opto-mechanical workstation. The part build-up program is controlled by a P150 host computer, linked directly to the DNC machining center. The direct manufacturing route is shown, including initial examples of simple objects (primitives -- cube, cylinder, cone) leading to more complex turbine blade generation, incorporating build-up techniques and the associated mechanical properties.

  14. One-component nanomedicine.

    PubMed

    Su, Hao; Koo, Jin Mo; Cui, Honggang

    2015-12-10

    One-component nanomedicine (OCN) represents an emerging class of therapeutic nanostructures that contain only one type of chemical substance. This one-component feature allows for fine-tuning and optimization of the drug loading and physicochemical properties of nanomedicine in a precise manner through molecular engineering of the underlying building blocks. Using a precipitation procedure or effective molecular assembly strategies, molecularly crafted therapeutic agents (e.g. polymer-drug conjugates, small molecule prodrugs, or drug amphiphiles) could involuntarily aggregate, or self-assemble into nanoscale objects of well-defined sizes and shapes. Unlike traditional carrier-based nanomedicines that are inherently multicomponent systems, an OCN does not require the use of additional carriers and could itself possess desired physicochemical features for preferential accumulation at target sites. We review here recent progress in the molecular design, conjugation methods, and fabrication strategies of OCN, and analyze the opportunities that this emerging platform could open for the new and improved treatment of devastating diseases such as cancer.

  15. Lifing of Engine Components

    NASA Technical Reports Server (NTRS)

    2005-01-01

    The successful development of advanced aerospace engines depends greatly on the capabilities of high performance materials and structures. Advanced materials, such as nickel based single crystal alloys, metal foam, advanced copper alloys, and ceramics matrix composites, have been engineered to provide higher engine temperature and stress capabilities. Thermal barrier coatings have been developed to improve component durability and fuel efficiency, by reducing the substrate hot wall metal temperature and protecting against oxidation and blanching. However, these coatings are prone to oxidation and delamination failures. In order to implement the use of these materials in advanced engines, it is necessary to understand and model the evolution of damage of the metal substrate as well as the coating under actual engine conditions. The models and the understanding of material behavior are utilized in the development of a life prediction methodology for hot section components. The research activities were focused on determining the stress and strain fields in an engine environment under combined thermo-mechanical loads to develop life prediction methodologies consistent with the observed damage formation of the coating and the substrates.

  16. Prognostics for Microgrid Components

    NASA Technical Reports Server (NTRS)

    Saxena, Abhinav

    2012-01-01

    Prognostics is the science of predicting future performance and potential failures based on targeted condition monitoring. Moving away from the traditional reliability centric view, prognostics aims at detecting and quantifying the time to impending failures. This advance warning provides the opportunity to take actions that can preserve uptime, reduce cost of damage, or extend the life of the component. The talk will focus on the concepts and basics of prognostics from the viewpoint of condition-based systems health management. Differences with other techniques used in systems health management and philosophies of prognostics used in other domains will be shown. Examples relevant to micro grid systems and subsystems will be used to illustrate various types of prediction scenarios and the resources it take to set up a desired prognostic system. Specifically, the implementation results for power storage and power semiconductor components will demonstrate specific solution approaches of prognostics. The role of constituent elements of prognostics, such as model, prediction algorithms, failure threshold, run-to-failure data, requirements and specifications, and post-prognostic reasoning will be explained. A discussion on performance evaluation and performance metrics will conclude the technical discussion followed by general comments on open research problems and challenges in prognostics.

  17. Component failure data handbook

    SciTech Connect

    Gentillon, C.D.

    1991-04-01

    This report presents generic component failure rates that are used in reliability and risk studies of commercial nuclear power plants. The rates are computed using plant-specific data from published probabilistic risk assessments supplemented by selected other sources. Each data source is described. For rates with four or more separate estimates among the sources, plots show the data that are combined. The method for combining data from different sources is presented. The resulting aggregated rates are listed with upper bounds that reflect the variability observed in each rate across the nuclear power plant industry. Thus, the rates are generic. Both per hour and per demand rates are included. They may be used for screening in risk assessments or for forming distributions to be updated with plant-specific data.

  18. Hyaluronan: A Matrix Component

    NASA Astrophysics Data System (ADS)

    Rügheimer, Louise

    2008-09-01

    The glucosaminoglycan hyaluronan is a key component of the extracellular matrix. It is a large, negatively charged molecule that can act as an ion exchange reservoir for positive ions. Hyaluronan is involved in renomedullary water handling through its water-binding capacity. In the renal medulla, the main source for hyaluronan production is the renomedullary interstitial cells. Hyaluronan synthases are found in the inner part of the plasma membrane and polymerize hyaluronan chains which are extruded into the extracellular space. Hyaluronidases are a family of enzymes involved in the degradation of hyaluronan. They have a wide range of properties, including differences in size, inhibitor sensitivities, catalytic mechanisms, substrate specificities and pH optima.

  19. Sprayed skin turbine component

    DOEpatents

    Allen, David B

    2013-06-04

    Fabricating a turbine component (50) by casting a core structure (30), forming an array of pits (24) in an outer surface (32) of the core structure, depositing a transient liquid phase (TLP) material (40) on the outer surface of the core structure, the TLP containing a melting-point depressant, depositing a skin (42) on the outer surface of the core structure over the TLP material, and heating the assembly, thus forming both a diffusion bond and a mechanical interlock between the skin and the core structure. The heating diffuses the melting-point depressant away from the interface. Subsurface cooling channels (35) may be formed by forming grooves (34) in the outer surface of the core structure, filling the grooves with a fugitive filler (36), depositing and bonding the skin (42), then removing the fugitive material.

  20. Precision Cleaning Titanium Components

    SciTech Connect

    Hand, T.E.; Bohnert, G.W.

    2000-02-02

    Clean bond surfaces are critical to the operation of diffusion bonded titanium engine components. These components can be contaminated with machining coolant, shop dirt, and fingerprints during normal processing and handling. These contaminants must be removed to achieve acceptable bond quality. As environmental concerns become more important in manufacturing, elimination of the use of hazardous materials is desired. For this reason, another process (not using nitric-hydrofluoric acid solution) to clean titanium parts before bonding was sought. Initial cleaning trials were conducted at Honeywell to screen potential cleaning techniques and chemistries. During the initial cleaning process screening phase, Pratt and Whitney provided Honeywell with machined 3 inch x 3 inch x 1 inch titanium test blocks. These test blocks were machined with a water-based machining coolant and exposed to a normal shop environment and handling. (Honeywell sectioned one of these blocks into smaller samples to be used for additional cleanliness verification analyses.) The sample test blocks were ultrasonically cleaned in alkaline solutions and AUGER analysis was used by Honeywell FM and T to validate their cleanliness. This information enabled selection of final cleaning techniques and solutions to be used for the bonding trials. To validate Honeywell's AUGER data and to verify the cleaning processes in actual situations, additional sample blocks were cleaned (using the chosen processes) and then bonded. The bond quality of the test blocks was analyzed according to Pratt and Whitney's requirements. The Charpy impact testing was performed according to ASTM procedure {number_sign}E-23. Bond quality was determined by examining metallographic samples of the bonded test blocks for porosity along the bondline.

  1. Optical communication components

    NASA Astrophysics Data System (ADS)

    Eldada, Louay

    2004-03-01

    We review and contrast key technologies developed to address the optical components market for communication applications. We first review the component requirements from a network perspective. We then look at different material systems, compare their properties, and describe the functions achieved to date in each of them. The material systems reviewed include silica fiber, silica on silicon, silicon on insulator, silicon oxynitride, sol-gels, polymers, thin-film dielectrics, lithium niobate, indium phosphide, gallium arsenide, magneto-optic materials, and birefringent crystals. We then describe the most commonly used classes of optical device technology and present their pros and cons as well as the functions achieved to date in each of them. The technologies reviewed include passive, actuation, and active technologies. The passive technologies described include fused fibers, dispersion-compensating fiber, beam steering, Bragg gratings, diffraction gratings, holographic elements, thin-film filters, photonic crystals, microrings, and birefringent elements. The actuation technologies include thermo-optics, electro-optics, acousto-optics, magneto-optics, electroabsorption, liquid crystals, total internal reflection technologies, and mechanical actuation. The active technologies include heterostructures, quantum wells, rare-earth doping, dye doping, Raman amplification, and semiconductor amplification. We also investigate the use of different material systems and device technologies to achieve building-block functions, including lasers, amplifiers, detectors, modulators, polarization controllers, couplers, filters, switches, attenuators, isolators, circulators, wavelength converters, chromatic dispersion compensators, and polarization mode dispersion compensators. Some of the technologies presented are well established in the industry and in some cases have reached the commodity stage, others have recently become ready for commercial introduction, while some others

  2. CO Component Estimation Based on the Independent Component Analysis

    NASA Astrophysics Data System (ADS)

    Ichiki, Kiyotomo; Kaji, Ryohei; Yamamoto, Hiroaki; Takeuchi, Tsutomu T.; Fukui, Yasuo

    2014-01-01

    Fast Independent Component Analysis (FastICA) is a component separation algorithm based on the levels of non-Gaussianity. Here we apply FastICA to the component separation problem of the microwave background, including carbon monoxide (CO) line emissions that are found to contaminate the PLANCK High Frequency Instrument (HFI) data. Specifically, we prepare 100 GHz, 143 GHz, and 217 GHz mock microwave sky maps, which include galactic thermal dust, NANTEN CO line, and the cosmic microwave background (CMB) emissions, and then estimate the independent components based on the kurtosis. We find that FastICA can successfully estimate the CO component as the first independent component in our deflection algorithm because its distribution has the largest degree of non-Gaussianity among the components. Thus, FastICA can be a promising technique to extract CO-like components without prior assumptions about their distributions and frequency dependences.

  3. CO component estimation based on the independent component analysis

    SciTech Connect

    Ichiki, Kiyotomo; Kaji, Ryohei; Yamamoto, Hiroaki; Takeuchi, Tsutomu T.; Fukui, Yasuo

    2014-01-01

    Fast Independent Component Analysis (FastICA) is a component separation algorithm based on the levels of non-Gaussianity. Here we apply FastICA to the component separation problem of the microwave background, including carbon monoxide (CO) line emissions that are found to contaminate the PLANCK High Frequency Instrument (HFI) data. Specifically, we prepare 100 GHz, 143 GHz, and 217 GHz mock microwave sky maps, which include galactic thermal dust, NANTEN CO line, and the cosmic microwave background (CMB) emissions, and then estimate the independent components based on the kurtosis. We find that FastICA can successfully estimate the CO component as the first independent component in our deflection algorithm because its distribution has the largest degree of non-Gaussianity among the components. Thus, FastICA can be a promising technique to extract CO-like components without prior assumptions about their distributions and frequency dependences.

  4. Filter Component Assessment

    SciTech Connect

    Alvin, M.A.; Lippert, T.E.; Diaz, E.S.; Smeltzer, E.E.

    1996-12-31

    Advanced particulate filtration systems are currently being developed at Westinghouse for use in both coal-fired Integrated Gasification Combined Cycle (IGCC) and Pressurized Fluidized Bed Combustion (PFBC) systems. To date, Westinghouse has demonstrated 5855 hours of successful operation of first generation monolithic filter elements in PFBC applications when ash bridging or process thermal transient excursions are avoided. Alternate advanced monolithic and second generation fiber reinforced, filament wound and vacuum infiltrated filters are also being developed which are considered to have enhanced high temperature creep resistance, improved fracture toughness, or enhanced thermal shock characteristics, respectively. Mechanical and component fabrication improvements, as well as degradation mechanisms for each filter element have been identified by Westinghouse during exposure to simulated PFBC operating conditions and alkali-containing steam/air environments. Additional effort is currently being focused on determining the stability of the advanced monolithic high temperature creep resistant clay bonded silicon carbide (SiC) materials, alumina/mullite, and chemically vapor infiltrated (CVI) SiC materials during operation in the Westinghouse Advanced Particulate Filtration (W-APF) system at Foster Wheeler`s pressurized circulating fluidized-bed combustion (PCFBC) test facility in Karhula, Finland. Select advanced filter materials are being defined for additional long-term exposure in integrated gasification combined cycle (IGCC) gas streams. The results of these efforts are summarized in this paper. 6 refs., 7 figs., 11 tabs.

  5. Initial Ada components evaluation

    NASA Technical Reports Server (NTRS)

    Moebes, Travis

    1989-01-01

    The SAIC has the responsibility for independent test and validation of the SSE. They have been using a mathematical functions library package implemented in Ada to test the SSE IV and V process. The library package consists of elementary mathematical functions and is both machine and accuracy independent. The SSE Ada components evaluation includes code complexity metrics based on Halstead's software science metrics and McCabe's measure of cyclomatic complexity. Halstead's metrics are based on the number of operators and operands on a logical unit of code and are compiled from the number of distinct operators, distinct operands, and total number of occurrences of operators and operands. These metrics give an indication of the physical size of a program in terms of operators and operands and are used diagnostically to point to potential problems. McCabe's Cyclomatic Complexity Metrics (CCM) are compiled from flow charts transformed to equivalent directed graphs. The CCM is a measure of the total number of linearly independent paths through the code's control structure. These metrics were computed for the Ada mathematical functions library using Software Automated Verification and Validation (SAVVAS), the SSE IV and V tool. A table with selected results was shown, indicating that most of these routines are of good quality. Thresholds for the Halstead measures indicate poor quality if the length metric exceeds 260 or difficulty is greater than 190. The McCabe CCM indicated a high quality of software products.

  6. Notch Signaling Components

    PubMed Central

    Liu, Zhi-Yan; Wu, Tao; Li, Qing; Wang, Min-Cong; Jing, Li; Ruan, Zhi-Ping; Yao, Yu; Nan, Ke-Jun; Guo, Hui

    2016-01-01

    Abstract Non-small-cell lung cancer (NSCLC) is a lethal and aggressive malignancy. Currently, the identities of prognostic and predictive makers of NSCLC have not been fully established. Dysregulated Notch signaling has been implicated in many human malignancies, including NSCLC. However, the prognostic value of measuring Notch signaling and the utility of developing Notch-targeted therapies in NSCLC remain inconclusive. The present study investigated the association of individual Notch receptor and ligand levels with lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) prognosis using the Kaplan-Meier plotte database. This online database encompasses 2437 lung cancer samples. Hazard ratios with 95% confidence intervals were calculated. The results showed that higher Notch1, Notch2, JAG1, and DLL1 mRNA expression predicted better overall survival (OS) in lung ADC, but showed no significance in SCC patients. Elevated Notch3, JAG2, and DLL3 mRNA expression was associated with poor OS of ADC patients, but not in SCC patients. There was no association between Notch4 and OS in either lung ADC or SCC patients. In conclusion, the set of Notch1, Notch2, JAG1, DLL1 and that of Notch3, JAG2, DLL3 played opposing prognostic roles in lung ADC patients. Neither set of Notch receptors and ligands was indicative of lung SCC prognosis. Notch signaling could serve as promising marker to predict outcomes in lung ADC patients. The distinct features of lung cancer subtypes and Notch components should be considered when developing future Notch-targeted therapies. PMID:27196489

  7. GOATS - Orbitology Component

    NASA Technical Reports Server (NTRS)

    Haber, Benjamin M.; Green, Joseph J.

    2010-01-01

    The GOATS Orbitology Component software was developed to specifically address the concerns presented by orbit analysis tools that are often written as stand-alone applications. These applications do not easily interface with standard JPL first-principles analysis tools, and have a steep learning curve due to their complicated nature. This toolset is written as a series of MATLAB functions, allowing seamless integration into existing JPL optical systems engineering modeling and analysis modules. The functions are completely open, and allow for advanced users to delve into and modify the underlying physics being modeled. Additionally, this software module fills an analysis gap, allowing for quick, high-level mission analysis trades without the need for detailed and complicated orbit analysis using commercial stand-alone tools. This software consists of a series of MATLAB functions to provide for geometric orbit-related analysis. This includes propagation of orbits to varying levels of generalization. In the simplest case, geosynchronous orbits can be modeled by specifying a subset of three orbit elements. The next case is a circular orbit, which can be specified by a subset of four orbit elements. The most general case is an arbitrary elliptical orbit specified by all six orbit elements. These orbits are all solved geometrically, under the basic problem of an object in circular (or elliptical) orbit around a rotating spheroid. The orbit functions output time series ground tracks, which serve as the basis for more detailed orbit analysis. This software module also includes functions to track the positions of the Sun, Moon, and arbitrary celestial bodies specified by right ascension and declination. Also included are functions to calculate line-of-sight geometries to ground-based targets, angular rotations and decompositions, and other line-of-site calculations. The toolset allows for the rapid execution of orbit trade studies at the level of detail required for the

  8. Cooling system for electronic components

    DOEpatents

    Anderl, William James; Colgan, Evan George; Gerken, James Dorance; Marroquin, Christopher Michael; Tian, Shurong

    2016-05-17

    Embodiments of the present invention provide for non interruptive fluid cooling of an electronic enclosure. One or more electronic component packages may be removable from a circuit card having a fluid flow system. When installed, the electronic component packages are coincident to and in a thermal relationship with the fluid flow system. If a particular electronic component package becomes non-functional, it may be removed from the electronic enclosure without affecting either the fluid flow system or other neighboring electronic component packages.

  9. Cooling system for electronic components

    SciTech Connect

    Anderl, William James; Colgan, Evan George; Gerken, James Dorance; Marroquin, Christopher Michael; Tian, Shurong

    2015-12-15

    Embodiments of the present invention provide for non interruptive fluid cooling of an electronic enclosure. One or more electronic component packages may be removable from a circuit card having a fluid flow system. When installed, the electronic component packages are coincident to and in a thermal relationship with the fluid flow system. If a particular electronic component package becomes non-functional, it may be removed from the electronic enclosure without affecting either the fluid flow system or other neighboring electronic component packages.

  10. Component-specific modeling. [jet engine hot section components

    NASA Technical Reports Server (NTRS)

    Mcknight, R. L.; Maffeo, R. J.; Tipton, M. T.; Weber, G.

    1992-01-01

    Accomplishments are described for a 3 year program to develop methodology for component-specific modeling of aircraft hot section components (turbine blades, turbine vanes, and burner liners). These accomplishments include: (1) engine thermodynamic and mission models, (2) geometry model generators, (3) remeshing, (4) specialty three-dimensional inelastic structural analysis, (5) computationally efficient solvers, (6) adaptive solution strategies, (7) engine performance parameters/component response variables decomposition and synthesis, (8) integrated software architecture and development, and (9) validation cases for software developed.

  11. Multi-component assembly casting

    DOEpatents

    James, Allister W.

    2015-10-13

    Multi-component vane segment and method for forming the same. Assembly includes: positioning a pre-formed airfoil component (12) and a preformed shroud heat resistant material (18) in a mold, wherein the airfoil component (12) and the shroud heat resistant material (18) each comprises an interlocking feature (24); preheating the mold; introducing molten structural material (46) into the mold; and solidifying the molten structural material such that it interlocks the pre-formed airfoil component (12) with respect to the preformed shroud heat resistant material (18) and is effective to provide structural support for the shroud heat resistant material (18). Surfaces between the airfoil component (12) and the structural material (46), between the airfoil component (12) and the shroud heat resistant material (18), and between the shroud heat resistant material (18) and the structural material (46) are free of metallurgical bonds.

  12. Semantic Annotation of Computational Components

    NASA Technical Reports Server (NTRS)

    Vanderbilt, Peter; Mehrotra, Piyush

    2004-01-01

    This paper describes a methodology to specify machine-processable semantic descriptions of computational components to enable them to be shared and reused. A particular focus of this scheme is to enable automatic compositon of such components into simple work-flows.

  13. Nickel-hydrogen component development

    NASA Technical Reports Server (NTRS)

    Charleston, J. A.

    1983-01-01

    Light weight energy storage systems for future space missions are investigated. One of the systems being studied is the nickel hydrogen battery. This battery is designed to achieve longer life, improve performance, and higher energy densities for space applications. The nickel hydrogen component development is discussed. Test data from polarization measurements of the hydrogen electrode component is presented.

  14. Regularized Generalized Structured Component Analysis

    ERIC Educational Resources Information Center

    Hwang, Heungsun

    2009-01-01

    Generalized structured component analysis (GSCA) has been proposed as a component-based approach to structural equation modeling. In practice, GSCA may suffer from multi-collinearity, i.e., high correlations among exogenous variables. GSCA has yet no remedy for this problem. Thus, a regularized extension of GSCA is proposed that integrates a ridge…

  15. Multi-Velocity Component LDV

    NASA Technical Reports Server (NTRS)

    Johnson, Dennis A. (Inventor)

    1996-01-01

    A laser doppler velocimeter uses frequency shifting of a laser beam to provide signal information for each velocity component. A composite electrical signal generated by a light detector is digitized and a processor produces a discrete Fourier transform based on the digitized electrical signal. The transform includes two peak frequencies corresponding to the two velocity components.

  16. RTI Essential Components Integrity Rubric

    ERIC Educational Resources Information Center

    National Center on Response to Intervention, 2011

    2011-01-01

    The Response to Intervention (RTI) Essential Components Integrity Rubric is for use by individuals who are responsible for monitoring school-level fidelity of RTI implementation. The rubric is aligned with "Essential Components of RTI: A Closer Look at Response to Intervention" (National Center on Response to Intervention, 2010).…

  17. Heat treating of manufactured components

    DOEpatents

    Ripley, Edward B [Knoxville, TN

    2012-05-22

    An apparatus for heat treating manufactured components using microwave energy and microwave susceptor material is disclosed. The system typically includes an insulating vessel placed within a microwave applicator chamber. A moderating material is positioned inside the insulating vessel so that a substantial portion of the exterior surface of each component for heat treating is in contact with the moderating material.

  18. Components of Successful Magnet Schools.

    ERIC Educational Resources Information Center

    Bryant, Faye B.

    This paper identifies and discusses components of successful magnet programs. It is based on a review of existing research literature and information gathered directly from school districts. First, the paper discusses separately the following elements, which are considered "core components": (1) leadership; (2) organizational structure; (3)…

  19. RTI Essential Components Integrity Worksheet

    ERIC Educational Resources Information Center

    National Center on Response to Intervention, 2011

    2011-01-01

    The Response to Intervention (RTI) Essential Components Integrity Rubric and the RTI Essential Components Integrity Worksheet are for use by individuals responsible for monitoring the school-level fidelity of Response to Intervention (RTI) implementation. They may also be used by schools for self-appraisal; however, they were not designed for…

  20. Multi-Component Dark Matter

    SciTech Connect

    Zurek, Kathryn M.

    2008-11-01

    We explore multi-component dark matter models where the dark sector consists of multiple stable states with different mass scales, and dark forces coupling these states further enrich the dynamics. The multi-component nature of the dark matter naturally arises in supersymmetric models, where both R parity and an additional symmetry, such as a Z{sub 2}, is preserved. We focus on a particular model where the heavier component of dark matter carries lepton number and annihilates mostly to leptons. The heavier component, which is essentially a sterile neutrino, naturally explains the PAMELA, ATIC and synchrotron signals, without an excess in antiprotons which typically mars other models of weak scale dark matter. The lighter component, which may have a mass from a GeV to a TeV, may explain the DAMA signal, and may be visible in low threshold runs of CDMS and XENON, which search for light dark matter.

  1. Pantaloon Hernia: Obstructed Indirect Component and Direct Component with Cryptorchidism.

    PubMed

    Kariappa, Mohan Kumar; Harihar, Vivek; Kothudum, Ashwini Rajareddy; Hiremath, Vivekanand Kedarlingayya

    2016-01-01

    Cryptorchidism is a condition in which one or both testes have not passed down into the scrotal sac. It is categorized as true undescended testis in which testes are present in the normal path of descent, and as ectopic testis, in which testes are present at abnormal site. Common complications of cryptorchidism are testicular torsion, subfertility, inguinal hernia, and testicular cancer. Here we present a rare case of pantaloon hernia of obstructed indirect component and direct component with cryptorchidism.

  2. Pantaloon Hernia: Obstructed Indirect Component and Direct Component with Cryptorchidism

    PubMed Central

    Kariappa, Mohan Kumar; Hiremath, Vivekanand Kedarlingayya

    2016-01-01

    Cryptorchidism is a condition in which one or both testes have not passed down into the scrotal sac. It is categorized as true undescended testis in which testes are present in the normal path of descent, and as ectopic testis, in which testes are present at abnormal site. Common complications of cryptorchidism are testicular torsion, subfertility, inguinal hernia, and testicular cancer. Here we present a rare case of pantaloon hernia of obstructed indirect component and direct component with cryptorchidism. PMID:27579208

  3. Vacuum Brazing of Accelerator Components

    NASA Astrophysics Data System (ADS)

    Singh, Rajvir; Pant, K. K.; Lal, Shankar; Yadav, D. P.; Garg, S. R.; Raghuvanshi, V. K.; Mundra, G.

    2012-11-01

    Commonly used materials for accelerator components are those which are vacuum compatible and thermally conductive. Stainless steel, aluminum and copper are common among them. Stainless steel is a poor heat conductor and not very common in use where good thermal conductivity is required. Aluminum and copper and their alloys meet the above requirements and are frequently used for the above purpose. The accelerator components made of aluminum and its alloys using welding process have become a common practice now a days. It is mandatory to use copper and its other grades in RF devices required for accelerators. Beam line and Front End components of the accelerators are fabricated from stainless steel and OFHC copper. Fabrication of components made of copper using welding process is very difficult and in most of the cases it is impossible. Fabrication and joining in such cases is possible using brazing process especially under vacuum and inert gas atmosphere. Several accelerator components have been vacuum brazed for Indus projects at Raja Ramanna Centre for Advanced Technology (RRCAT), Indore using vacuum brazing facility available at RRCAT, Indore. This paper presents details regarding development of the above mentioned high value and strategic components/assemblies. It will include basics required for vacuum brazing, details of vacuum brazing facility, joint design, fixturing of the jobs, selection of filler alloys, optimization of brazing parameters so as to obtain high quality brazed joints, brief description of vacuum brazed accelerator components etc.

  4. Apparatus for remotely handling components

    DOEpatents

    Szkrybalo, Gregory A.; Griffin, Donald L.

    1994-01-01

    The inventive apparatus for remotely handling bar-like components which define a longitudinal direction includes a gripper mechanism for gripping the component including first and second gripper members longitudinally fixedly spaced from each other and oriented parallel to each other in planes transverse to the longitudinal direction. Each gripper member includes a jaw having at least one V-groove with opposing surfaces intersecting at a base and extending radially relative to the longitudinal direction for receiving the component in an open end between the opposing surfaces. The V-grooves on the jaw plate of the first and second gripper members are aligned in the longitudinal direction to support the component in the first and second gripper members. A jaw is rotatably mounted on and a part of each of the first and second gripper members for selectively assuming a retracted mode in which the open end of the V-groove is unobstructed and active mode in which the jaw spans the open end of the V-groove in the first and second gripper members. The jaw has a locking surface for contacting the component in the active mode to secure the component between the locking surface of the jaw and the opposing surfaces of the V-groove. The locking surface has a plurality of stepped portions, each defining a progressively decreasing radial distance between the base of the V-groove and the stepped portion opposing the base to accommodate varying sizes of components.

  5. Component Fragility Research Program: Phase 1 component prioritization

    SciTech Connect

    Holman, G.S.; Chou, C.K.

    1987-06-01

    Current probabilistic risk assessment (PRA) methods for nuclear power plants utilize seismic ''fragilities'' - probabilities of failure conditioned on the severity of seismic input motion - that are based largely on limited test data and on engineering judgment. Under the NRC Component Fragility Research Program (CFRP), the Lawrence Livermore National Laboratory (LLNL) has developed and demonstrated procedures for using test data to derive probabilistic fragility descriptions for mechanical and electrical components. As part of its CFRP activities, LLNL systematically identified and categorized components influencing plant safety in order to identify ''candidate'' components for future NRC testing. Plant systems relevant to safety were first identified; within each system components were then ranked according to their importance to overall system function and their anticipated seismic capacity. Highest priority for future testing was assigned to those ''very important'' components having ''low'' seismic capacity. This report describes the LLNL prioritization effort, which also included application of ''high-level'' qualification data as an alternate means of developing probabilistic fragility descriptions for PRA applications.

  6. Ceramic component for MHD electrode

    DOEpatents

    Marchant, David D.; Bates, Junior L.

    1981-01-01

    A ceramic component which exhibits electrical conductivity down to near room temperatures has the formula: Hf.sub.x In.sub.y A.sub.z O.sub.2 where x=0.1 to 0.4, y=0.3 to 0.6, z=0.1 to 0.4 and A is a lanthanide rare earth or yttrium. The component is suitable for use in the fabrication of MHD electrodes or as the current leadout portion of a composite electrode with other ceramic components.

  7. Ceramic components for MHD electrode

    DOEpatents

    Marchant, D.D.

    A ceramic component which exhibits electrical conductivity down to near room temperatures has the formula: Hf/sub x/In/sub y/A/sub z/O/sub 2/ where x = 0.1 to 0.4, y = 0.3 to 0.6, z = 0.1 to 0.4 and A is a lanthanide rare earth or yttrium. The component is suitable for use in the fabrication of MHD electrodes or as the current leadout portion of a composite electrode with other ceramic components.

  8. Component Based Electronic Voting Systems

    NASA Astrophysics Data System (ADS)

    Lundin, David

    An electronic voting system may be said to be composed of a number of components, each of which has a number of properties. One of the most attractive effects of this way of thinking is that each component may have an attached in-depth threat analysis and verification strategy. Furthermore, the need to include the full system when making changes to a component is minimised and a model at this level can be turned into a lower-level implementation model where changes can cascade to as few parts of the implementation as possible.

  9. Three-component homeostasis control

    NASA Astrophysics Data System (ADS)

    Xu, Jin; Hong, Hyunsuk; Jo, Junghyo

    2014-03-01

    Two reciprocal components seem to be sufficient to maintain a control variable constant. However, pancreatic islets adapt three components to control glucose homeostasis. They are α (secreting glucagon), β (insulin), and δ (somatostatin) cells. Glucagon and insulin are the reciprocal hormones for increasing and decreasing blood glucose levels, while the role of somatostatin is unknown. However, it has been known how each hormone affects other cell types. Based on the pulsatile hormone secretion and the cellular interactions, this system can be described as coupled oscillators. In particular, we used the Landau-Stuart model to consider both amplitudes and phases of hormone oscillations. We found that the presence of the third component, δ cell, was effective to resist under glucose perturbations, and to quickly return to the normal glucose level once perturbed. Our analysis suggested that three components are necessary for advanced homeostasis control.

  10. Optimizing connected component labeling algorithms

    NASA Astrophysics Data System (ADS)

    Wu, Kesheng; Otoo, Ekow; Shoshani, Arie

    2005-04-01

    This paper presents two new strategies that can be used to greatly improve the speed of connected component labeling algorithms. To assign a label to a new object, most connected component labeling algorithms use a scanning step that examines some of its neighbors. The first strategy exploits the dependencies among them to reduce the number of neighbors examined. When considering 8-connected components in a 2D image, this can reduce the number of neighbors examined from four to one in many cases. The second strategy uses an array to store the equivalence information among the labels. This replaces the pointer based rooted trees used to store the same equivalence information. It reduces the memory required and also produces consecutive final labels. Using an array instead of the pointer based rooted trees speeds up the connected component labeling algorithms by a factor of 5 ~ 100 in our tests on random binary images.

  11. Laser marking of component parts

    SciTech Connect

    Gress, A.V. Jr.

    1983-01-01

    Permanent identification of components and subassemblies for traceability and historical purposes is essential for assemblies subject to long term storage. Marketing requirements run the gamut from simple functional alphanumerics for terminal or wire numbers to complex component identification involving program nomenclature, part number, manufacturer's code, serial number, data code, and lot or batch number. The wide range of opaque materials marked includes both ferrous and nonferrous materials, plastics, composites, and ceramics.

  12. Open Component Portability Infrastructure (OPENCPI)

    DTIC Science & Technology

    2013-03-01

    OPEN COMPONENT PORTABILITY INFRASTRUCTURE (OPENCPI) MERCURY FEDERAL SYSTEMS, INC. MARCH 2013 FINAL TECHNICAL REPORT...NUMBER OC 5f. WORK UNIT NUMBER PI 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Mercury Federal Systems, Inc. 1901 South Bell Street, Suite...Component Portability Infrastructure (OPENCPI) ,” AFRL-RI-RS-TR- 2009-257, Mercury Federal Systems, Inc., Arlington, VA, Nov 2009. 2. Kulp, J., “OpenCPI

  13. Blood component collection by apheresis.

    PubMed

    Burgstaler, Edwin A

    2006-07-01

    Apheresis component collection is a rapidly growing area in the blood collection field. Several instruments with varying capabilities are available. This is a brief review of the equipment available for granulocyte and apheresis component collection and indications for their use. In the United States, granulocytes are collected with the Fenwal CS3000, Fenwal CS3000 Plus, COBE (Gambro) Spectra, Haemonetics LN9000, and Fresenius AS 104. The use of hetastarch for sedimenting agent and stimulation with G-CSF and G-CSF plus dexamethasone have substantially increased granulocyte yields. Plateletapheresis is performed in the United States on the Fenwal CS3000, Fenwal CS3000 Plus, Fenwal Amicus, COBE (Gambro) Spectra, Gambro Trima Version 4, Gambro Trima Accel (Version 5), and Haemonetics LN9000. Automated red blood cell (RBC) collections are performed with the Haemonetics MCS+LN8150, Gambro Trima Version 4, Gambro Trima Accel (Version 5), Amicus, and Baxter Alyx. The RBC can be collected concurrently (with other components) in some instruments or separately in others. Plasma is collected concurrently on several instruments. Plasmapheresis for plasma only is performed on the Fenwal Autopheresis C and Haemonetics PCS2. Granulocyte yields range from 0.46 x 10(10) to 1.0 x 10(10) for unstimulated donors and 2.1 x 10(10) to 2.6 x 10(10) for donors stimulated with dexamethasone or prednisone. The use of G-CSF and G-CSF with dexamethasone has substantially increased granulocyte yields with yields of 4.1 x 10(10) to 10.8 x 10(10) reported. Platelet collection rates of 0.045-0.115 x 10(11) plt/min have been reported. Collection efficiencies of 46-85.7% have been reported. Automated (apheresis) component collection has the advantages of controlled volumes or doses of component, efficient use of the donor, multiple components from the same donor, better inventory control, and better quality control due to less manipulation of the individual components. Disadvantages of automated

  14. Components of vestibular cortical function.

    PubMed

    Klingner, Carsten M; Volk, Gerd F; Flatz, Claudia; Brodoehl, Stefan; Dieterich, Marianne; Witte, Otto W; Guntinas-Lichius, Orlando

    2013-01-01

    It is known that the functional response (e.g., nystagmus) to caloric vestibular stimulation is delayed and prolonged compared with the stimulus-response timing of other sensory systems. Imaging studies have used different models to predict cortical responses and to determine the areas of the brain that are involved. These studies have revealed a widespread network of vestibular brain regions. However, there is some disagreement regarding the brain areas involved, which may partly be caused by differences in the models used. This disagreement indicates the possible existence of multiple cortical components with different temporal characteristics that underlie cortical vestibular processing. However, data-driven methods have yet to be used to analyze the underlying hemodynamic components during and after vestibular stimulation. We performed functional magnetic resonance imaging (fMRI) on 12 healthy subjects during caloric stimulation and analyzed these data using a model-free analysis method (ICA). We found seven independent stimulus-induced components that outline a robust pattern of cortical activation and deactivation. These independent components demonstrated significant differences in their time courses. No single-modeled response function was able to cover the entire range of these independent components. The response functions determined in the present study should improve model-based studies investigating vestibular cortical processing.

  15. Subsystems component definitions summary program

    NASA Technical Reports Server (NTRS)

    Scott, A. Don; Thomas, Carolyn C.; Simonsen, Lisa C.; Hall, John B., Jr.

    1991-01-01

    A computer program, the Subsystems Component Definitions Summary (SUBCOMDEF), was developed to provide a quick and efficient means of summarizing large quantities of subsystems component data in terms of weight, volume, resupply, and power. The program was validated using Space Station Freedom Program Definition Requirements Document data for the internal and external thermal control subsystem. Once all component descriptions, unit weights and volumes, resupply, and power data are input, the user may obtain a summary report of user-specified portions of the subsystem or of the entire subsystem as a whole. Any combination or all of the parameters of wet and dry weight, wet and dry volume, resupply weight and volume, and power may be displayed. The user may vary the resupply period according to individual mission requirements, as well as the number of hours per day power consuming components operate. Uses of this program are not limited only to subsystem component summaries. Any applications that require quick, efficient, and accurate weight, volume, resupply, or power summaries would be well suited to take advantage of SUBCOMDEF's capabilities.

  16. Failure Analysis of Ceramic Components

    SciTech Connect

    B.W. Morris

    2000-06-29

    Ceramics are being considered for a wide range of structural applications due to their low density and their ability to retain strength at high temperatures. The inherent brittleness of monolithic ceramics requires a departure from the deterministic design philosophy utilized to analyze metallic structural components. The design program ''Ceramic Analysis and Reliability Evaluation of Structures Life'' (CARES/LIFE) developed by NASA Lewis Research Center uses a probabilistic approach to predict the reliability of monolithic components under operational loading. The objective of this study was to develop an understanding of the theories used by CARES/LIFE to predict the reliability of ceramic components and to assess the ability of CARES/LIFE to accurately predict the fast fracture behavior of monolithic ceramic components. A finite element analysis was performed to determine the temperature and stress distribution of a silicon carbide O-ring under diametral compression. The results of the finite element analysis were supplied as input into CARES/LIFE to determine the fast fracture reliability of the O-ring. Statistical material strength parameters were calculated from four-point flexure bar test data. The predicted reliability showed excellent correlation with O-ring compression test data indicating that the CARES/LIFE program can be used to predict the reliability of ceramic components subjected to complicated stress states using material properties determined from simple uniaxial tensile tests.

  17. Towards Prognostics for Electronics Components

    NASA Technical Reports Server (NTRS)

    Saha, Bhaskar; Celaya, Jose R.; Wysocki, Philip F.; Goebel, Kai F.

    2013-01-01

    Electronics components have an increasingly critical role in avionics systems and in the development of future aircraft systems. Prognostics of such components is becoming a very important research field as a result of the need to provide aircraft systems with system level health management information. This paper focuses on a prognostics application for electronics components within avionics systems, and in particular its application to an Isolated Gate Bipolar Transistor (IGBT). This application utilizes the remaining useful life prediction, accomplished by employing the particle filter framework, leveraging data from accelerated aging tests on IGBTs. These tests induced thermal-electrical overstresses by applying thermal cycling to the IGBT devices. In-situ state monitoring, including measurements of steady-state voltages and currents, electrical transients, and thermal transients are recorded and used as potential precursors of failure.

  18. Automated cleaning of electronic components

    SciTech Connect

    Drotning, W.; Meirans, L.; Wapman, W.; Hwang, Y.; Koenig, L.; Petterson, B.

    1994-07-01

    Environmental and operator safety concerns are leading to the elimination of trichloroethylene and chlorofluorocarbon solvents in cleaning processes that remove rosin flux, organic and inorganic contamination, and particulates from electronic components. Present processes depend heavily on these solvents for manual spray cleaning of small components and subassemblies. Use of alternative solvent systems can lead to longer processing times and reduced quality. Automated spray cleaning can improve the quality of the cleaning process, thus enabling the productive use of environmentally conscious materials, while minimizing personnel exposure to hazardous materials. We describe the development of a prototype robotic system for cleaning electronic components in a spray cleaning workcell. An important feature of the prototype system is the capability to generate the robot paths and motions automatically from the CAD models of the part to be cleaned, and to embed cleaning process knowledge into the automatically programmed operations.

  19. Additive manufacturing of optical components

    NASA Astrophysics Data System (ADS)

    Heinrich, Andreas; Rank, Manuel; Maillard, Philippe; Suckow, Anne; Bauckhage, Yannick; Rößler, Patrick; Lang, Johannes; Shariff, Fatin; Pekrul, Sven

    2016-08-01

    The development of additive manufacturing methods has enlarged rapidly in recent years. Thereby, the work mainly focuses on the realization of mechanical components, but the additive manufacturing technology offers a high potential in the field of optics as well. Owing to new design possibilities, completely new solutions are possible. This article briefly reviews and compares the most important additive manufacturing methods for polymer optics. Additionally, it points out the characteristics of additive manufactured polymer optics. Thereby, surface quality is of crucial importance. In order to improve it, appropriate post-processing steps are necessary (e.g. robot polishing or coating), which will be discussed. An essential part of this paper deals with various additive manufactured optical components and their use, especially in optical systems for shape metrology (e.g. borehole sensor, tilt sensor, freeform surface sensor, fisheye lens). The examples should demonstrate the potentials and limitations of optical components produced by additive manufacturing.

  20. Transducer for downhole drilling components

    DOEpatents

    Hall, David R; Fox, Joe R

    2006-05-30

    A robust transmission element for transmitting information between downhole tools, such as sections of drill pipe, in the presence of hostile environmental conditions, such as heat, dirt, rocks, mud, fluids, lubricants, and the like. The transmission element maintains reliable connectivity between transmission elements, thereby providing an uninterrupted flow of information between drill string components. A transmission element is mounted within a recess proximate a mating surface of a downhole drilling component, such as a section of drill pipe. The transmission element may include an annular housing forming a trough, an electrical conductor disposed within the trough, and an MCEI material disposed between the annular housing and the electrical conductor.

  1. Independent Component Analysis of Textures

    NASA Technical Reports Server (NTRS)

    Manduchi, Roberto; Portilla, Javier

    2000-01-01

    A common method for texture representation is to use the marginal probability densities over the outputs of a set of multi-orientation, multi-scale filters as a description of the texture. We propose a technique, based on Independent Components Analysis, for choosing the set of filters that yield the most informative marginals, meaning that the product over the marginals most closely approximates the joint probability density function of the filter outputs. The algorithm is implemented using a steerable filter space. Experiments involving both texture classification and synthesis show that compared to Principal Components Analysis, ICA provides superior performance for modeling of natural and synthetic textures.

  2. SLC nomenclature for beamline components

    SciTech Connect

    Paterson, J.; Silva, J.

    1984-07-12

    The purpose of this report is to document the SLC nomenclature conventions for beamline components. Included are recent enhancements which should lead to a more consistant usage of the ''unit number'' part of beamline device names. The attached pages are divided into three sections. The first section is a brief summary for the general user. The second section is a more amplified description for those who need more detailed interpretations of device names. The third section contains a few notes for those who must generate device names for new components.

  3. LSST control software component design

    NASA Astrophysics Data System (ADS)

    Lotz, Paul J.; Dubois-Felsmann, Gregory P.; Lim, Kian-Tat; Johnson, Tony; Chandrasekharan, Srinivasan; Mills, David; Daly, Philip; Schumacher, Germán.; Delgado, Francisco; Pietrowicz, Steve; Selvy, Brian; Sebag, Jacques; Marshall, Stuart; Sundararaman, Harini; Contaxis, Christopher; Bovill, Robert; Jenness, Tim

    2016-08-01

    Construction of the Large Synoptic Survey Telescope system involves several different organizations, a situation that poses many challenges at the time of the software integration of the components. To ensure commonality for the purposes of usability, maintainability, and robustness, the LSST software teams have agreed to the following for system software components: a summary state machine, a manner of managing settings, a flexible solution to specify controller/controllee relationships reliably as needed, and a paradigm for responding to and communicating alarms. This paper describes these agreed solutions and the factors that motivated these.

  4. Sampling Errors of Variance Components.

    ERIC Educational Resources Information Center

    Sanders, Piet F.

    A study on sampling errors of variance components was conducted within the framework of generalizability theory by P. L. Smith (1978). The study used an intuitive approach for solving the problem of how to allocate the number of conditions to different facets in order to produce the most stable estimate of the universe score variance. Optimization…

  5. Components in interstellar molecular hydrogen

    NASA Technical Reports Server (NTRS)

    Spitzer, L., Jr.; Morton, W. A.

    1976-01-01

    Results are reported for precise spectrophotometric measurements of the profiles of selected Lyman absorption lines produced by hydrogen molecules in various rotational levels along the line of sight to 13 stars which have shown some evidence for an increase in line width with increasing rotational quantum number (J). The line profiles were measured by multiple scans with the Copernicus satellite telescope. Based on analysis of the radial velocities, derivations of the column densities, and line-profile fitting, the following conclusions are made: (1) the increase in interstellar H2 line width with increasing J results from the presence of the most shortward component, which is relatively weak at low J but becomes more important at higher J; (2) the relative column densities found for the different J levels in each component may be fitted by a theoretical model in which rotational excitation is due to absorption of UV photons followed by radiative quadrupole spontaneous transitions or collisionally induced downward transitions between different J levels; (3) the atomic hydrogen density is between 300 and 1000 per cu cm in the most shortward component for each of three stars; (4) the approaching gas which produces each shortward component must be in the form of thin sheets; and (5) the sheets are the compressed gas behind a shock front moving through the interstellar medium.

  6. Factor Analysis via Components Analysis

    ERIC Educational Resources Information Center

    Bentler, Peter M.; de Leeuw, Jan

    2011-01-01

    When the factor analysis model holds, component loadings are linear combinations of factor loadings, and vice versa. This interrelation permits us to define new optimization criteria and estimation methods for exploratory factor analysis. Although this article is primarily conceptual in nature, an illustrative example and a small simulation show…

  7. Large Component Removal/Disposal

    SciTech Connect

    Wheeler, D. M.

    2002-02-27

    This paper describes the removal and disposal of the large components from Maine Yankee Atomic Power Plant. The large components discussed include the three steam generators, pressurizer, and reactor pressure vessel. Two separate Exemption Requests, which included radiological characterizations, shielding evaluations, structural evaluations and transportation plans, were prepared and issued to the DOT for approval to ship these components; the first was for the three steam generators and one pressurizer, the second was for the reactor pressure vessel. Both Exemption Requests were submitted to the DOT in November 1999. The DOT approved the Exemption Requests in May and July of 2000, respectively. The steam generators and pressurizer have been removed from Maine Yankee and shipped to the processing facility. They were removed from Maine Yankee's Containment Building, loaded onto specially designed skid assemblies, transported onto two separate barges, tied down to the barges, th en shipped 2750 miles to Memphis, Tennessee for processing. The Reactor Pressure Vessel Removal Project is currently under way and scheduled to be completed by Fall of 2002. The planning, preparation and removal of these large components has required extensive efforts in planning and implementation on the part of all parties involved.

  8. MCFC component development at ANL.

    SciTech Connect

    Bloom, I.

    1998-09-15

    Argonne National Laboratory is developing advanced cathode and electrolyte components for the molten carbonate fuel cell (MCFC). Working in support of the MCFC developers, the goal of this effort is to extend the life of the MCFC cell and to improve its performance.

  9. Environmental Forces - Some Esthetic Components.

    ERIC Educational Resources Information Center

    Severino, D. Alexander

    Although our system of mass culture has raised our civilization to an extremely high level of material success and affluence, the fact remains that this system has the inherent flaw of not fully recognizing the esthetic needs of man. To overcome this weakness we need to re-introduce into the system a sizable component of first-hand experience…

  10. Components of dynamic digital maps

    NASA Astrophysics Data System (ADS)

    Condit, Christopher D.

    1999-05-01

    The core of a dynamic digital map (DDM) is a program created to display a digital geologic map and its associated data set as a single integrated package. This DDM program core is authored using a high-level object oriented graphical programming environment, SuperCard, a Macintosh `xTalk' language. Some of the major philosophical underpinnings relevant to the job of creating DDMs in this programming environment include taking advantage of specific object's attributes, how to organize data structure effectively for this job and keeping applicable code as transportable (generalized) as possible between objects. The core components of DDMs are parts of a SuperCard `template' or map display `container' into which the various externally created digital pieces (e.g. CAD produced geologic maps, spread sheet data, digital images, text files, movies) can be inserted for integrated display and digital publication. Components of DDMs consist of windows, cards within these windows, card fields (text and data containers) and a menu structure. The paper discusses each of these major components and how they fit into a DDM and gives examples of each topic in programs whose components demonstrate the concept. These programs are available from Web (see Appendix A); readers can refer to them as they examine these examples.

  11. Fabrication of plastic microfluidic components

    NASA Astrophysics Data System (ADS)

    Martin, Peter M.; Matson, Dean W.; Bennett, Wendy D.; Hammerstrom, D. J.

    1998-09-01

    Plastic components have many advantages, including ease of fabrication, low cost, chemical inertness, lightweight, and disposability. We report on the fabrication of three plastics-based microfluidic components: a motherboard, a dialysis unit, and a metal sensor. Microchannels, headers, and interconnects were produced in thin sheets (>=50 microns) of polyimide, PMMA, polyethylene, and polycarbonate using a direct-write excimer laser micromachining system. Machined sheets were laminated by thermal and adhesive bonding to form leak-tight microfluidic components. The microfluidic motherboard borrowed the `functionality on a chip' concept from the electronics industry and was the heart of a complex microfluidic analytical device. The motherboard platform was designed to be tightly integrated and self-contained (i.e., liquid flows are all confined within machined microchannels), reducing the need for tubing with fluid distribution and connectivity. This concept greatly facilitated system integration and miniaturization. As fabricated, the motherboard consisted of three fluid reservoirs connected to micropumps by microchannels. The fluids could either be pumped independently or mixed in microchannels prior to being directed to exterior analytical components via outlet ports. The microdialysis device was intended to separate electrolytic solutes from low volume samples prior to mass spectrometric analysis. The device consisted of a dialysis membrane laminated between opposed serpentine microchannels containing the sample fluid and a buffer solution. The laminated metal sensor consisted of fluid reservoirs, micro-flow channels, micropumps, mixing channels, reaction channels, and detector circuitry.

  12. Early Components to Childhood Literacy.

    ERIC Educational Resources Information Center

    Crown, Sid

    Within the fundamental context of "how children learn to read," attention is drawn towards an understanding of the "components" that are necessary for the child to move from oral language to early literacy. Looking at this transition requires the educator to consider whether literacy can develop as naturally for the child as speaking, or if not,…

  13. Nuclear component horizontal seismic restraint

    DOEpatents

    Snyder, Glenn J.

    1988-01-01

    A nuclear component horizontal seismic restraint. Small gaps limit horizontal displacement of components during a seismic occurrence and therefore reduce dynamic loadings on the free lower end. The reactor vessel and reactor guard vessel use thicker section roll-forged rings welded between the vessel straight shell sections and the bottom hemispherical head sections. The inside of the reactor guard vessel ring forging contains local vertical dovetail slots and upper ledge pockets to mount and retain field fitted and installed blocks. As an option, the horizontal displacement of the reactor vessel core support cone can be limited by including shop fitted/installed local blocks in opposing alignment with the reactor vessel forged ring. Beams embedded in the wall of the reactor building protrude into apertures in the thermal insulation shell adjacent the reactor guard vessel ring and have motion limit blocks attached thereto to provide to a predetermined clearance between the blocks and reactor guard vessel ring.

  14. Component characterization and development 2

    NASA Astrophysics Data System (ADS)

    Smith, Jacqueline D.

    1993-09-01

    The effort entitled, 'Component Characterization and Development II' was established in the Rome Lab Photonics Center Analog & Lightwave Photonics Branch as part of the overall in-house program plan to advanced the state-of-the-art in optics and electrooptics. The objective of the effort is to specify, acquire, and/or develop components for Air Force Command, Control, Communications, and Intelligence (C3I) applications. The source of prototype devices was designated to include academia, industry, and government organizations. Actual performance data was measured for both electro-optic and fiber-optic based devices that were of interest to communications, spatial laser control, and optical beamforming applications. Additionally, several novel approaches to device fabrication were investigated through a BAA contract with Syracuse University.

  15. Composite components on commercial aircraft

    NASA Technical Reports Server (NTRS)

    Dexter, H. B.

    1980-01-01

    Commercial aircraft manufacturers are making production commitments to composite structure for future aircraft and modifications to current production aircraft. Flight service programs with advanced composites sponsored by NASA during the past 10 years are described. Approximately 2.5 million total composite component flight hours have been accumulated since 1970 on both commercial transports and helicopters. Design concepts with significant mass savings were developed, appropriate inspection and maintenance procedures were established, and satisfactory service was achieved for the various composite components. A major NASA/U.S. industry technology program to reduce fuel consumption of commercial transport aircraft through the use of advanced composites was undertaken. Ground and flight environmental effects on the composite materials used in the flight service programs supplement the flight service evaluation.

  16. HG ion thruster component testing

    NASA Technical Reports Server (NTRS)

    Mantenieks, M. A.

    1979-01-01

    Cathodes, isolators, and vaporizers are critical components in determining the performance and lifetime of mercury ion thrusters. The results of life tests of several of these components are reported. A 30-cm thruster CIV test in a bell jar has successfully accumulated over 26,000 hours. The cathode has undergone 65 restarts during the life test without requiring any appreciable increases in starting power. Recently, all restarts have been achieved with only the 44 volt keeper supply with no change required in the starting power. Another ongoing 30-cm Hg thruster cathode test has successfully passed the 10,000 hour mark. A solid-insert, 8-cm thruster cathode has accumulated over 4,000 hours of thruster operation. All starts have been achieved without the use of a high voltage ignitor. The results of this test indicate that the solid impregnated insert is a viable neutralizer cathode for the 8-cm thruster.

  17. Centrifugal slip casting of components

    SciTech Connect

    Steinlage, G.A.; Roeder, R.K.; Trumble, K.P.; Bowman, K.J.

    1996-05-01

    Research in layered and functionally gradient materials has emerged because of the increasing demand for high-performance engineering materials. Many techniques have been used to produce layered and functionally gradient components. Common examples include thermal spray processing, powder processing, chemical and physical vapor deposition, high-temperature or combustion synthesis, diffusion treatments, microwave processing and infiltration. Of these techniques, powder processing routes offer excellent microstructural control and product quality, and they are capable of producing large components. Centrifugal slip casting is a powder-processing technique combining the effects of slip casting and centrifugation. In slip casting, consolidation takes place as fluid is removed by the porous mold. Particles within the slip move with the suspending fluid until reaching the mold wall, at which point they are consolidated. In centrifugation, particles within the slip move through the fluid at a rate dependent upon the gravitational force and particle drag.

  18. Mechanical component screening for scanner

    NASA Technical Reports Server (NTRS)

    Olson, J. L.; Quinn, W. J.

    1972-01-01

    The critical mechanical components of the scan mirror mechanism are described and their evaluation and screening procedures are discussed. A bumper/damper unit is used in the design to reverse motion of the mirror and effect scan and retrace cycles. A wear evaluation was conducted on the bumper impact surfaces that established nylon 6-10 as an acceptable material. The elastomeric dampers were subjected to thermal vacuum tests for condensables and outgassing as well as parametric life tests. The flexure pivots that support the mirror were tested to establish a curve of stress plotted as a function of cycles to failure for rotational operation. The pivots met the life requirement of 150,000,000 cycles at a + or - 2.9 deg amplitude during fatigue testing. Screening procedures were established for dampers and flexure pivots to obtain flight quality components.

  19. Three-component gyrotropic metamaterial

    NASA Astrophysics Data System (ADS)

    Tralle, Igor; ZiÈ©ba, Paweł; Paśko, Wioletta

    2014-06-01

    All of the proposed ever since designs of metamaterials are characterized by ever-increasing sophistication of fabrication methods. Here, a comparatively simple recipe for the fabrication of a metamaterial, which is both gyrotropic and of the simultaneously negative permittivity and permeability, is proposed. The idea is to make a mixture of three ingredients, where one of them would be responsible for the negativity of μ, while the other two would be responsible for the negativity of ɛ. The first component of the mixture is the "swarm" of single-domain ferromagnetic nano-particles, immersed in a mixture of other two, silver and mercury cadmium telluride. By carrying out the computer simulations, the domains of gyromagnetic metamaterial exist, relative to all parameters characterizing the model, that is, the temperature, external magnetic field, parameters of nano-particles, and the fraction of cadmium in Hg1-xCdxTe-compound as well as relative concentrations of the mixture components are established.

  20. Quasar redshifts: the intrinsic component

    NASA Astrophysics Data System (ADS)

    Hansen, Peter M.

    2016-09-01

    The large observed redshift of quasars has suggested large cosmological distances and a corresponding enormous energy output to explain the brightness or luminosity as seen at earth. Alternative or complementary sources of redshift have not been identified by the astronomical community. This study examines one possible source of additional redshift: an intrinsic component based on the plasma characteristics of high temperature and high electron density which are believed to be present.

  1. Driven one-component plasmas

    SciTech Connect

    Rizzato, Felipe B.; Pakter, Renato; Levin, Yan

    2009-08-15

    A statistical theory is presented that allows the calculation of the stationary state achieved by a driven one-component plasma after a process of collisionless relaxation. The stationary Vlasov equation with appropriate boundary conditions is reduced to an ordinary differential equation, which is then solved numerically. The solution is then compared with the molecular-dynamics simulation. A perfect agreement is found between the theory and the simulations. The full current-voltage phase diagram is constructed.

  2. Safe administration of blood components.

    PubMed

    Hurrell, Katy

    The transfusion process has many stages, each involving different members of staff in different locations. This gives rise to a significant potential for errors. Nurses are involved in many of these stages and therefore require knowledge, skills and competence in the process to ensure the safety of patients. This third article in our five-part series on blood transfusion discusses the safe administration of blood components and the key principles to which nurses must adhere.

  3. Hg ion thruster component testing

    NASA Technical Reports Server (NTRS)

    Mantenieks, M. A.

    1979-01-01

    Electron bombardment thrusters, under development to provide both auxiliary and primary propulsion functions for a large variety of space missions are tested. Thruster design verification which requires life tests of durations of the order of the time anticipated in space applications, are discussed. The life time and reliability of an electron bombardment thruster is dependent upon the performance of several critical components including cathodes, vaporizers, and isolators. The performances of the cathode, vaporizer, and propellant isolaters during fatigue analyses are examined.

  4. Design for pressure regulating components

    NASA Technical Reports Server (NTRS)

    Wichmann, H.

    1973-01-01

    The design development for Pressure Regulating Components included a regulator component trade-off study with analog computer performance verification to arrive at a final optimized regulator configuration for the Space Storable Propulsion Module, under development for a Jupiter Orbiter mission. This application requires the pressure regulator to be capable of long-term fluorine exposure. In addition, individual but basically identical (for purposes of commonality) units are required for separate oxidizer and fuel pressurization. The need for dual units requires improvement in the regulation accuracy over present designs. An advanced regulator concept was prepared featuring redundant bellows, all metallic/ceramic construction, friction-free guidance of moving parts, gas damping, and the elimination of coil springs normally used for reference forces. The activities included testing of actual size seat/poppet components to determine actual discharge coefficients and flow forces. The resulting data was inserted into the computer model of the regulator. Computer simulation of the propulsion module performance over two mission profiles indicated satisfactory minimization of propellant residual requirements imposed by regulator performance uncertainties.

  5. Automated cleaning of electronic components

    SciTech Connect

    Drotning, W.

    1994-03-01

    Environmental and operator safety concerns are leading to the elimination of trichloroethylene (TCE) and chlorofluorocarbon (CFC) solvents in electronic component cleaning processes that remove rosin flux, organic and inorganic contamination, and particulates. Present processes depend heavily on these solvents for manual spray cleaning of small components and subassemblies. Use of alternative solvent systems can lead to longer processing times and reduced quality. Automated spray cleaning can improve the quality of the cleaning process, thus enabling the productive use of environmentally conscious materials, while minimizing personnel exposure to hazardous materials. In addition, the use of robotic and automated systems can reduce the manual handling of parts that necessitates additional cleaning. We describe the development of a prototype robotic system for cleaning electronic components in a spray cleaning workcell. An important feature of the prototype system is the capability to generate the robot paths and motions automatically from the CAD models of the part to be cleaned, and to embed cleaning process knowledge into the automatically programmed operations.

  6. Component-Based Visualization System

    NASA Technical Reports Server (NTRS)

    Delgado, Francisco

    2005-01-01

    A software system has been developed that gives engineers and operations personnel with no "formal" programming expertise, but who are familiar with the Microsoft Windows operating system, the ability to create visualization displays to monitor the health and performance of aircraft/spacecraft. This software system is currently supporting the X38 V201 spacecraft component/system testing and is intended to give users the ability to create, test, deploy, and certify their subsystem displays in a fraction of the time that it would take to do so using previous software and programming methods. Within the visualization system there are three major components: the developer, the deployer, and the widget set. The developer is a blank canvas with widget menu items that give users the ability to easily create displays. The deployer is an application that allows for the deployment of the displays created using the developer application. The deployer has additional functionality that the developer does not have, such as printing of displays, screen captures to files, windowing of displays, and also serves as the interface into the documentation archive and help system. The third major component is the widget set. The widgets are the visual representation of the items that will make up the display (i.e., meters, dials, buttons, numerical indicators, string indicators, and the like). This software was developed using Visual C++ and uses COTS (commercial off-the-shelf) software where possible.

  7. Laser ultrasonic multi-component imaging

    DOEpatents

    Williams, Thomas K [Federal Way, WA; Telschow, Kenneth [Des Moines, WA

    2011-01-25

    Techniques for ultrasonic determination of the interfacial relationship of multi-component systems are discussed. In implementations, a laser energy source may be used to excite a multi-component system including a first component and a second component at least in partial contact with the first component. Vibrations resulting from the excitation may be detected for correlation with a resonance pattern indicating if discontinuity exists at the interface of the first and second components.

  8. Optimal Arrangement of Components Via Pairwise Rearrangements.

    DTIC Science & Technology

    1987-10-01

    reliability function under component pairwise rearrangement. They use this property to find the optimal component arrangement. Worked examples illustrate the methods proposed. Keywords: Optimization; Permutations; Nodes.

  9. Component Control System for a Vehicle

    NASA Technical Reports Server (NTRS)

    Fraser-Chanpong, Nathan (Inventor); Spain, Ivan (Inventor); Dawson, Andrew D. (Inventor); Bluethmann, William J. (Inventor); Lee, Chunhao J. (Inventor); Vitale, Robert L. (Inventor); Guo, Raymond (Inventor); Waligora, Thomas M. (Inventor); Akinyode, Akinjide Akinniyi (Inventor); Reed, Ryan M. (Inventor)

    2016-01-01

    A vehicle includes a chassis, a modular component, and a central operating system. The modular component is supported by the chassis. The central operating system includes a component control system, a primary master controller, and a secondary master controller. The component control system is configured for controlling the modular component. The primary and secondary master controllers are in operative communication with the component control system. The primary and secondary master controllers are configured to simultaneously transmit commands to the component control system. The component control system is configured to accept commands from the secondary master controller only when a fault occurs in the primary master controller.

  10. Inductive robust principal component analysis.

    PubMed

    Bao, Bing-Kun; Liu, Guangcan; Xu, Changsheng; Yan, Shuicheng

    2012-08-01

    In this paper we address the error correction problem that is to uncover the low-dimensional subspace structure from high-dimensional observations, which are possibly corrupted by errors. When the errors are of Gaussian distribution, Principal Component Analysis (PCA) can find the optimal (in terms of least-square-error) low-rank approximation to highdimensional data. However, the canonical PCA method is known to be extremely fragile to the presence of gross corruptions. Recently, Wright et al. established a so-called Robust Principal Component Analysis (RPCA) method, which can well handle grossly corrupted data [14]. However, RPCA is a transductive method and does not handle well the new samples which are not involved in the training procedure. Given a new datum, RPCA essentially needs to recalculate over all the data, resulting in high computational cost. So, RPCA is inappropriate for the applications that require fast online computation. To overcome this limitation, in this paper we propose an Inductive Robust Principal Component Analysis (IRPCA) method. Given a set of training data, unlike RPCA that targets on recovering the original data matrix, IRPCA aims at learning the underlying projection matrix, which can be used to efficiently remove the possible corruptions in any datum. The learning is done by solving a nuclear norm regularized minimization problem, which is convex and can be solved in polynomial time. Extensive experiments on a benchmark human face dataset and two video surveillance datasets show that IRPCA can not only be robust to gross corruptions, but also handle well the new data in an efficient way.

  11. TFTR CAMAC systems and components

    SciTech Connect

    Rauch, W.A.; Bergin, W.; Sichta, P.

    1987-08-01

    Princeton's tokamak fusion test reactor (TFTR) utilizes Computer Automated Measurement and Control (CAMAC) to provide instrumentation for real and quasi real time control, monitoring, and data acquisition systems. This paper describes and discusses the complement of CAMAC hardware systems and components that comprise the interface for tokamak control and measurement instrumentation, and communication with the central instrumentation control and data acquisition (CICADA) system. It also discusses CAMAC reliability and calibration, types of modules used, a summary of data acquisition and control points, and various diagnostic maintenance tools used to support and troubleshoot typical CAMAC systems on TFTR.

  12. Parallel Assembly of LIGA Components

    SciTech Connect

    Christenson, T.R.; Feddema, J.T.

    1999-03-04

    In this paper, a prototype robotic workcell for the parallel assembly of LIGA components is described. A Cartesian robot is used to press 386 and 485 micron diameter pins into a LIGA substrate and then place a 3-inch diameter wafer with LIGA gears onto the pins. Upward and downward looking microscopes are used to locate holes in the LIGA substrate, pins to be pressed in the holes, and gears to be placed on the pins. This vision system can locate parts within 3 microns, while the Cartesian manipulator can place the parts within 0.4 microns.

  13. Modeling Systems of Dependent Components

    DTIC Science & Technology

    2014-09-17

    Ross Sheldon Ross , Babak Haji 611102 c. THIS PAGE The public reporting burden for this collection of information is estimated to average 1 hour per...08/18/2011 Received Paper 3.00 6.00 7.00 5.00 4.00 1.00 2.00 Sheldon Ross . Simulation Analysis of System Life when Component Lives are Determined by...Stochastic Model , Annals of Operations Research (02 2012) Sheldon Ross . A Markov Chai Choice Problem , Probability in the Engineering and

  14. Photonic crystals as optical components

    NASA Astrophysics Data System (ADS)

    Halevi, P.; Krokhin, A. A.; Arriaga, J.

    1999-11-01

    Photonic crystals (PCs) have already found numerous applications associated with the photonic band gap. We point out that PCs could be also employed as custom-made optical components in the linear region well below the photonic gap. As an example, we discuss a birefringent PC lens that acts as a polarizing beam splitter. This idea is supported by a precise method of calculation of the optical constants of a transparent two-dimensional (2D) PC. Such a process of homogenization is performed for hexagonal arrays of polymer-based PCs and also for the mammalian cornea. Finally, 2D PCs are classified as optically uniaxial or biaxial.

  15. Rotor component displacement measurement system

    DOEpatents

    Mercer, Gary D.; Li, Ming C.; Baum, Charles R.

    2003-05-27

    A measuring system for measuring axial displacement of a tube relative to an axially stationary component in a rotating rotor assembly includes at least one displacement sensor adapted to be located normal to a longitudinal axis of the tube; an insulated cable system adapted for passage through the rotor assembly; a rotatable proximitor module located axially beyond the rotor assembly to which the cables are connected; and a telemetry system operatively connected to the proximitor module for sampling signals from the proximitor module and forwarding data to a ground station.

  16. Enhancing Reserve Component Unit Training

    DTIC Science & Technology

    1987-05-01

    Training Guidance, 4 Dec 85. 10TH MTN DIV, FT DRUM, NY 10 MTN DIV REG 350-1 (Draft), Undtd, Training. 10 MTN DIV CIR 350-8, 21 Mar 86, Officer...Professionalism Program. 10 MTN DIV CIR 350-2, 25 Oct 85, Training School Guidance. 10 MTN DIV CIR 350-1, 15 Sep 85, Procedures for (OPFOR) Weapons...Army War College. Pelton, John Dew , Colonel, US Army, "Reserve Component Combat Readiness in 192 Hours Per Year?," Oct 75, U.S. Army War College

  17. Principal components analysis competitive learning.

    PubMed

    López-Rubio, Ezequiel; Ortiz-de-Lazcano-Lobato, Juan Miguel; Muñoz-Pérez, José; Gómez-Ruiz, José Antonio

    2004-11-01

    We present a new neural model that extends the classical competitive learning by performing a principal components analysis (PCA) at each neuron. This model represents an improvement with respect to known local PCA methods, because it is not needed to present the entire data set to the network on each computing step. This allows a fast execution while retaining the dimensionality-reduction properties of the PCA. Furthermore, every neuron is able to modify its behavior to adapt to the local dimensionality of the input distribution. Hence, our model has a dimensionality estimation capability. The experimental results we present show the dimensionality-reduction capabilities of the model with multisensor images.

  18. Open Component Portability Infrastructure (OPENCPI)

    DTIC Science & Technology

    2009-11-01

    AFRL-RI-RS-TR-2009-257 Final Technical Report November 2009 OPEN COMPONENT PORTABILITY INFRASTRUCTURE (OPENCPI) Mercury ...ORGANIZATION NAME(S) AND ADDRESS(ES) Mercury Federal Systems, Inc. 1901 South Bell Street, Suite 402 Arlington, VA 22202-4511 8. PERFORMING ORGANIZATION...APPLICATIONS  30  6.0  REFERENCES  31  7.0  LIST OF ABBRVIATIONS AND ACRONYMS  32  APPENDIX A: ADDITIONAL REFERENCES  34  APPENDIX B:  MERCURY  CPI ITAR

  19. Components of Adenovirus Genome Packaging

    PubMed Central

    Ahi, Yadvinder S.; Mittal, Suresh K.

    2016-01-01

    Adenoviruses (AdVs) are icosahedral viruses with double-stranded DNA (dsDNA) genomes. Genome packaging in AdV is thought to be similar to that seen in dsDNA containing icosahedral bacteriophages and herpesviruses. Specific recognition of the AdV genome is mediated by a packaging domain located close to the left end of the viral genome and is mediated by the viral packaging machinery. Our understanding of the role of various components of the viral packaging machinery in AdV genome packaging has greatly advanced in recent years. Characterization of empty capsids assembled in the absence of one or more components involved in packaging, identification of the unique vertex, and demonstration of the role of IVa2, the putative packaging ATPase, in genome packaging have provided compelling evidence that AdVs follow a sequential assembly pathway. This review provides a detailed discussion on the functions of the various viral and cellular factors involved in AdV genome packaging. We conclude by briefly discussing the roles of the empty capsids, assembly intermediates, scaffolding proteins, portal vertex and DNA encapsidating enzymes in AdV assembly and packaging. PMID:27721809

  20. Three-component gyrotropic metamaterial

    SciTech Connect

    Tralle, Igor Ziȩba, Paweł; Paśko, Wioletta

    2014-06-21

    All of the proposed ever since designs of metamaterials are characterized by ever-increasing sophistication of fabrication methods. Here, a comparatively simple recipe for the fabrication of a metamaterial, which is both gyrotropic and of the simultaneously negative permittivity and permeability, is proposed. The idea is to make a mixture of three ingredients, where one of them would be responsible for the negativity of μ, while the other two would be responsible for the negativity of ε. The first component of the mixture is the “swarm” of single-domain ferromagnetic nano-particles, immersed in a mixture of other two, silver and mercury cadmium telluride. By carrying out the computer simulations, the domains of gyromagnetic metamaterial exist, relative to all parameters characterizing the model, that is, the temperature, external magnetic field, parameters of nano-particles, and the fraction of cadmium in Hg{sub 1−x}Cd{sub x}Te-compound as well as relative concentrations of the mixture components are established.

  1. Structural Studies of Ciliary Components

    PubMed Central

    Mizuno, Naoko; Taschner, Michael; Engel, Benjamin D.; Lorentzen, Esben

    2012-01-01

    Cilia are organelles found on most eukaryotic cells, where they serve important functions in motility, sensory reception, and signaling. Recent advances in electron tomography have facilitated a number of ultrastructural studies of ciliary components that have significantly improved our knowledge of cilium architecture. These studies have produced nanometer‐resolution structures of axonemal dynein complexes, microtubule doublets and triplets, basal bodies, radial spokes, and nexin complexes. In addition to these electron tomography studies, several recently published crystal structures provide insights into the architecture and mechanism of dynein as well as the centriolar protein SAS-6, important for establishing the 9-fold symmetry of centrioles. Ciliary assembly requires intraflagellar transport (IFT), a process that moves macromolecules between the tip of the cilium and the cell body. IFT relies on a large 20-subunit protein complex that is thought to mediate the contacts between ciliary motor and cargo proteins. Structural investigations of IFT complexes are starting to emerge, including the first three‐dimensional models of IFT material in situ, revealing how IFT particles organize into larger train-like arrays, and the high-resolution structure of the IFT25/27 subcomplex. In this review, we cover recent advances in the structural and mechanistic understanding of ciliary components and IFT complexes. PMID:22683354

  2. Bioactive Components in Fish Venoms

    PubMed Central

    Ziegman, Rebekah; Alewood, Paul

    2015-01-01

    Animal venoms are widely recognized excellent resources for the discovery of novel drug leads and physiological tools. Most are comprised of a large number of components, of which the enzymes, small peptides, and proteins are studied for their important bioactivities. However, in spite of there being over 2000 venomous fish species, piscine venoms have been relatively underrepresented in the literature thus far. Most studies have explored whole or partially fractioned venom, revealing broad pharmacology, which includes cardiovascular, neuromuscular, cytotoxic, inflammatory, and nociceptive activities. Several large proteinaceous toxins, such as stonustoxin, verrucotoxin, and Sp-CTx, have been isolated from scorpaenoid fish. These form pores in cell membranes, resulting in cell death and creating a cascade of reactions that result in many, but not all, of the physiological symptoms observed from envenomation. Additionally, Natterins, a novel family of toxins possessing kininogenase activity have been found in toadfish venom. A variety of smaller protein toxins, as well as a small number of peptides, enzymes, and non-proteinaceous molecules have also been isolated from a range of fish venoms, but most remain poorly characterized. Many other bioactive fish venom components remain to be discovered and investigated. These represent an untapped treasure of potentially useful molecules. PMID:25941767

  3. Bayesian robust principal component analysis.

    PubMed

    Ding, Xinghao; He, Lihan; Carin, Lawrence

    2011-12-01

    A hierarchical Bayesian model is considered for decomposing a matrix into low-rank and sparse components, assuming the observed matrix is a superposition of the two. The matrix is assumed noisy, with unknown and possibly non-stationary noise statistics. The Bayesian framework infers an approximate representation for the noise statistics while simultaneously inferring the low-rank and sparse-outlier contributions; the model is robust to a broad range of noise levels, without having to change model hyperparameter settings. In addition, the Bayesian framework allows exploitation of additional structure in the matrix. For example, in video applications each row (or column) corresponds to a video frame, and we introduce a Markov dependency between consecutive rows in the matrix (corresponding to consecutive frames in the video). The properties of this Markov process are also inferred based on the observed matrix, while simultaneously denoising and recovering the low-rank and sparse components. We compare the Bayesian model to a state-of-the-art optimization-based implementation of robust PCA; considering several examples, we demonstrate competitive performance of the proposed model.

  4. GMES Space Component: Programme overview

    NASA Astrophysics Data System (ADS)

    Aschbacher, J.; Milagro-Perez, M. P.

    2012-04-01

    The European Union (EU) and the European Space Agency (ESA) have developed the Global Monitoring for Environment and Security (GMES) programme as Europe's answer to the vital need for joined-up data about our climate, environment and security. Through a unique combination of satellite, atmospheric and Earth-based monitoring systems, the initiative will provide new insight into the state of the land, sea and air, providing policymakers, scientists, businesses and the public with accurate and timely information. GMES capabilities include monitoring and forecasting of climatic change, flood risks, soil and coastal erosion, crop and fish resources, air pollution, greenhouse gases, iceberg distribution and snow cover, among others. To accomplish this, GMES has been divided into three main components: Space, In-situ and Services. The Space Component, led by ESA, comprises five types of new satellites called Sentinels that are being developed by ESA specifically to meet the needs of GMES, the first of which to be launched in 2013. These missions carry a range of technologies, such as radar and multi-spectral imaging instruments for land, ocean and atmospheric monitoring. In addition, access to data from the so-called Contributing Missions guarantees that European space infrastructure is fully used for GMES. An integrated Ground Segment ensures access to Sentinels and Contributing Missions data. The in-situ component, under the coordination of the European Environment Agency (EEA), is composed of atmospheric and Earth based monitoring systems, and based on established networks and programmes at European and international levels. The European Commission is in charge of implementing the services component of GMES and of leading GMES overall. GMES services, fed with data from the Space and In-situ components, will provide essential information in five main domains, atmosphere, ocean and land monitoring as well as emergency response and security. Climate change has been added

  5. Shock absorbing mount for electrical components

    NASA Technical Reports Server (NTRS)

    Dillon, R. F., Jr.; Mayne, R. C. (Inventor)

    1975-01-01

    A shock mount for installing electrical components on circuit boards is described. The shock absorber is made of viscoelastic material which interconnects the electrical components. With this system, shocks imposed on one component of the circuit are not transmitted to other components. A diagram of a typical circuit is provided.

  6. Method for vacuum pressing electrochemical cell components

    NASA Technical Reports Server (NTRS)

    Andrews, Craig C. (Inventor); Murphy, Oliver J. (Inventor)

    2004-01-01

    Assembling electrochemical cell components using a bonding agent comprising aligning components of the electrochemical cell, applying a bonding agent between the components to bond the components together, placing the components within a container that is essentially a pliable bag, and drawing a vacuum within the bag, wherein the bag conforms to the shape of the components from the pressure outside the bag, thereby holding the components securely in place. The vacuum is passively maintained until the adhesive has cured and the components are securely bonded. The bonding agent used to bond the components of the electrochemical cell may be distributed to the bonding surface from distribution channels in the components. To prevent contamination with bonding agent, some areas may be treated to produce regions of preferred adhesive distribution and protected regions. Treatments may include polishing, etching, coating and providing protective grooves between the bonding surfaces and the protected regions.

  7. Heavy Water Components Test Reactor Decommissioning - Major Component Removal

    SciTech Connect

    Austin, W.; Brinkley, D.

    2010-05-05

    The Heavy Water Components Test Reactor (HWCTR) facility (Figure 1) was built in 1961, operated from 1962 to 1964, and is located in the northwest quadrant of the Savannah River Site (SRS) approximately three miles from the site boundary. The HWCTR facility is on high, well-drained ground, about 30 meters above the water table. The HWCTR was a pressurized heavy water test reactor used to develop candidate fuel designs for heavy water power reactors. It was not a defense-related facility like the materials production reactors at SRS. The reactor was moderated with heavy water and was rated at 50 megawatts thermal power. In December of 1964, operations were terminated and the facility was placed in a standby condition as a result of the decision by the U.S. Atomic Energy Commission to redirect research and development work on heavy water power reactors to reactors cooled with organic materials. For about one year, site personnel maintained the facility in a standby status, and then retired the reactor in place. In 1965, fuel assemblies were removed, systems that contained heavy water were drained, fluid piping systems were drained, deenergized and disconnected and the spent fuel basin was drained and dried. The doors of the reactor facility were shut and it wasn't until 10 years later that decommissioning plans were considered and ultimately postponed due to budget constraints. In the early 1990s, DOE began planning to decommission HWCTR again. Yet, in the face of new budget constraints, DOE deferred dismantlement and placed HWCTR in an extended surveillance and maintenance mode. The doors of the reactor facility were welded shut to protect workers and discourage intruders. The $1.6 billion allocation from the American Recovery and Reinvestment Act to SRS for site clean up at SRS has opened the doors to the HWCTR again - this time for final decommissioning. During the lifetime of HWCTR, 36 different fuel assemblies were tested in the facility. Ten of these

  8. Functional Generalized Structured Component Analysis.

    PubMed

    Suk, Hye Won; Hwang, Heungsun

    2016-12-01

    An extension of Generalized Structured Component Analysis (GSCA), called Functional GSCA, is proposed to analyze functional data that are considered to arise from an underlying smooth curve varying over time or other continua. GSCA has been geared for the analysis of multivariate data. Accordingly, it cannot deal with functional data that often involve different measurement occasions across participants and a large number of measurement occasions that exceed the number of participants. Functional GSCA addresses these issues by integrating GSCA with spline basis function expansions that represent infinite-dimensional curves onto a finite-dimensional space. For parameter estimation, functional GSCA minimizes a penalized least squares criterion by using an alternating penalized least squares estimation algorithm. The usefulness of functional GSCA is illustrated with gait data.

  9. Rosin components identified in diapers.

    PubMed

    Karlberg, A T; Magnusson, K

    1996-03-01

    As part of the investigation of sources of exposure to rosin allergens, disposable diapers (napkins) common on the Swedish market were analyzed, using gas chromatography, to detect the main rosin compounds. Rosin components were detected in all diapers, the highest amounts in those from the 2 major producers. In these diapers, more rosin was found in the top layer, which is in close contact with the skin than in the fluff. Despite the possibly minimal risk of induction of sensitization to rosin allergens in diapers, there is a real risk of elicitation of dermatitis in sensitive individuals, especially since penetration is enhanced by occlusion and irritation. Such material is not only used for infant diapers, but also for adult incontinence products and feminine hygiene products.

  10. Fast Steerable Principal Component Analysis

    PubMed Central

    Zhao, Zhizhen; Shkolnisky, Yoel; Singer, Amit

    2016-01-01

    Cryo-electron microscopy nowadays often requires the analysis of hundreds of thousands of 2-D images as large as a few hundred pixels in each direction. Here, we introduce an algorithm that efficiently and accurately performs principal component analysis (PCA) for a large set of 2-D images, and, for each image, the set of its uniform rotations in the plane and their reflections. For a dataset consisting of n images of size L × L pixels, the computational complexity of our algorithm is O(nL3 + L4), while existing algorithms take O(nL4). The new algorithm computes the expansion coefficients of the images in a Fourier–Bessel basis efficiently using the nonuniform fast Fourier transform. We compare the accuracy and efficiency of the new algorithm with traditional PCA and existing algorithms for steerable PCA. PMID:27570801

  11. Inelastic behavior of structural components

    NASA Technical Reports Server (NTRS)

    Hussain, N.; Khozeimeh, K.; Toridis, T. G.

    1980-01-01

    A more accurate procedure was developed for the determination of the inelastic behavior of structural components. The actual stress-strain curve for the mathematical of the structure was utilized to generate the force-deformation relationships for the structural elements, rather than using simplified models such as elastic-plastic, bilinear and trilinear approximations. relationships were generated for beam elements with various types of cross sections. In the generational of these curves, stress or load reversals, kinematic hardening and hysteretic behavior were taken into account. Intersections between loading and unloading branches were determined through an iterative process. Using the inelastic properties obtained, the plastic static response of some simple structural systems composed of beam elements was computed. Results were compared with known solutions, indicating a considerable improvement over response predictions obtained by means of simplified approximations used in previous investigations.

  12. Parallel supercomputing with commodity components

    SciTech Connect

    Warren, M.S.; Goda, M.P.; Becker, D.J.

    1997-09-01

    We have implemented a parallel computer architecture based entirely upon commodity personal computer components. Using 16 Intel Pentium Pro microprocessors and switched fast ethernet as a communication fabric, we have obtained sustained performance on scientific applications in excess of one Gigaflop. During one production astrophysics treecode simulation, we performed 1.2 x 10{sup 15} floating point operations (1.2 Petaflops) over a three week period, with one phase of that simulation running continuously for two weeks without interruption. We report on a variety of disk, memory and network benchmarks. We also present results from the NAS parallel benchmark suite, which indicate that this architecture is competitive with current commercial architectures. In addition, we describe some software written to support efficient message passing, as well as a Linux device driver interface to the Pentium hardware performance monitoring registers.

  13. Multi-tipped optical component

    DOEpatents

    D'urso, Brian R; Simpson, John T

    2010-04-13

    An optical component includes a support structure having a first composition including a recessive phase material and a second composition including protrusive phase material, the protrusive phase material defining a plurality of spaced apart surface features, each of the surface features comprising a distal end opposite the support structure, integrated with the support structure, and protruding distally from a surface of the support structure, each of the surface features reducing in cross sectional area distally from the support structure to provide a lowest cross sectional area at the distal end, the recessive phase material supporting and separating the surface features and defining a contiguous recessed surface area between the surface features, at least two of the protrusive features being characterized as optical waveguides.

  14. Fast Steerable Principal Component Analysis.

    PubMed

    Zhao, Zhizhen; Shkolnisky, Yoel; Singer, Amit

    2016-03-01

    Cryo-electron microscopy nowadays often requires the analysis of hundreds of thousands of 2-D images as large as a few hundred pixels in each direction. Here, we introduce an algorithm that efficiently and accurately performs principal component analysis (PCA) for a large set of 2-D images, and, for each image, the set of its uniform rotations in the plane and their reflections. For a dataset consisting of n images of size L × L pixels, the computational complexity of our algorithm is O(nL(3) + L(4)), while existing algorithms take O(nL(4)). The new algorithm computes the expansion coefficients of the images in a Fourier-Bessel basis efficiently using the nonuniform fast Fourier transform. We compare the accuracy and efficiency of the new algorithm with traditional PCA and existing algorithms for steerable PCA.

  15. Components of the Goeckerman regimen.

    PubMed

    Le Vine, M J; White, H A; Parrish, J A

    1979-08-01

    Although application of tar products and subsequent exposure to ultraviolet radiation (the Goeckerman regimen) has repeatedly been demonstrated to be effective therapy for psoriasis, the therapeutic role of each component has remained uncertain. Utilizing the bilateral comparison technique in 30 hospitalized patients with chronic stable plaque-type psoriasis vulgaris, we closely monitored the clinical responses to ultraviolet radiation (Westinghouse fluorescent FS40 bulbs, 290--400 nm) and a variety of tar preparations and lubricant vehicles in combination and separately. We found that: 1) 4 weeks of maximally-aggressive exposure to ultraviolet radiation alone will markedly improve, but not completely clear, psoriasis unless combined with a tar preparation or lubricating base; 2) 5% crude coal tar plus ultraviolet radiation offers no clear advantage or benefit over lubricating base plus ultraviolet radiation; and 3) none of the tar preparations tested offered any consistent advantage over any other preparation.

  16. Parallel supercomputing with commodity components

    NASA Technical Reports Server (NTRS)

    Warren, M. S.; Goda, M. P.; Becker, D. J.

    1997-01-01

    We have implemented a parallel computer architecture based entirely upon commodity personal computer components. Using 16 Intel Pentium Pro microprocessors and switched fast ethernet as a communication fabric, we have obtained sustained performance on scientific applications in excess of one Gigaflop. During one production astrophysics treecode simulation, we performed 1.2 x 10(sup 15) floating point operations (1.2 Petaflops) over a three week period, with one phase of that simulation running continuously for two weeks without interruption. We report on a variety of disk, memory and network benchmarks. We also present results from the NAS parallel benchmark suite, which indicate that this architecture is competitive with current commercial architectures. In addition, we describe some software written to support efficient message passing, as well as a Linux device driver interface to the Pentium hardware performance monitoring registers.

  17. NEXT Thruster Component Verification Testing

    NASA Technical Reports Server (NTRS)

    Pinero, Luis R.; Sovey, James S.

    2007-01-01

    Component testing is a critical part of thruster life validation activities under NASA s Evolutionary Xenon Thruster (NEXT) project testing. The high voltage propellant isolators were selected for design verification testing. Even though they are based on a heritage design, design changes were made because the isolators will be operated under different environmental conditions including temperature, voltage, and pressure. The life test of two NEXT isolators was therefore initiated and has accumulated more than 10,000 hr of operation. Measurements to date indicate only a negligibly small increase in leakage current. The cathode heaters were also selected for verification testing. The technology to fabricate these heaters, developed for the International Space Station plasma contactor hollow cathode assembly, was transferred to Aerojet for the fabrication of the NEXT prototype model ion thrusters. Testing the contractor-fabricated heaters is necessary to validate fabrication processes for high reliability heaters. This paper documents the status of the propellant isolator and cathode heater tests.

  18. Rebound: A Framework for Automated Component Adaptation

    NASA Technical Reports Server (NTRS)

    Penix, John; Lau, Sonie (Technical Monitor)

    1998-01-01

    The REBOUND adaptation framework organizes a collection of adaptation tactics in a way that they can be selected based on the components available for adaptation. Adaptation tactics are specified formally in terms of the relationship between the component to be adapted and the resulting adapted component. The tactic specifications are used as matching conditions for specification-based component retrieval, creating a 'retrieval for adaptation' scenario. The results of specification matching are used to guide component adaptation. Several examples illustrate how the framework guides component and tactic selection and how basic tactics are composed to form more powerful tactics.

  19. Molecular Components of Catalytic Selectivity

    SciTech Connect

    Somorjai, Gabor A.; Park, Jeong Y.

    2008-07-02

    Selectivity, that is, to produce one molecule out of many other thermodynamically feasible product molecules, is the key concept to develop 'clean manufacturing' processes that do not produce byproducts (green chemistry). Small differences in potential energy barriers for elementary reaction steps control which reaction channel is more likely to yield the desired product molecule (selectivity), instead of the overall activation energy for the reaction that controls turnover rates (activity). Recent studies have demonstrated the atomic- or molecular-level tailoring of parameters such as the surface structures of active sites that give rise to nanoparticle size and shape dependence of turnover rates and reaction selectivities. Here, we highlight seven molecular components that influence reaction selectivities. These include: surface structure, adsorbate-induced restructuring, adsorbate mobility, reaction intermediates, surface composition, charge transport, and oxidation states for model metal single crystal and colloid nanoparticle catalysts. We show examples of their functioning and describe in-situ instruments that permit us to investigate their roles in surface reactions.

  20. Precision fiducialization of transport components

    SciTech Connect

    Fischer, G.E.; Bressler, V.E.; Cobb, J.K.; Jensen, D.R.; Ruland, R.E.; Walz, H.V.; Williams, S.H.

    1992-03-01

    The Final Focus Test Beam (FFTB) is a transport line designed to test both concept and advanced technology for application to future linear colliders. It is currently under construction at SLAC in the central beam line. Most of the quadrupoles of the FFTB have ab initio alignment tolerances of less than 30 microns, if the planned for beam based alignment tuning procedure is to converge. For such placement tolerances to have any meaning requires that the coordinates of the effective centers, seen by the beam particles, be tansferred to tooling (that can be reached by mechanical or optical alignment methods) located on the outside of the components to comparable or better values. We have constructed an apparatus that simultaneously locates to micron tolerances, the effective magnetic center of fussing lenses, as well as the electrical center of beam position monitors (BPM) imbedded therein, and once located, for transferring these coordinates to specially mounted tooling frames that supported the external retroreflectors used in a laser tracker based alignment of the beam line. Details of construction as well as experimental results from the method are presented.

  1. High temperature two component explosive

    DOEpatents

    Mars, James E.; Poole, Donald R.; Schmidt, Eckart W.; Wang, Charles

    1981-01-01

    A two component, high temperature, thermally stable explosive composition comprises a liquid or low melting oxidizer and a liquid or low melting organic fuel. The oxidizer and fuel in admixture are incapable of substantial spontaneous exothermic reaction at temperatures on the order of 475.degree. K. At temperatures on the order of 475.degree. K., the oxidizer and fuel in admixture have an activation energy of at least about 40 kcal/mol. As a result of the high activation energy, the preferred explosive compositions are nondetonable as solids at ambient temperature, and become detonable only when heated beyond the melting point. Preferable oxidizers are selected from alkali or alkaline earth metal nitrates, nitrites, perchlorates, and/or mixtures thereof. Preferred fuels are organic compounds having polar hydrophilic groups. The most preferred fuels are guanidinium nitrate, acetamide and mixtures of the two. Most preferred oxidizers are eutectic mixtures of lithium nitrate, potassium nitrate and sodium nitrate, of sodium nitrite, sodium nitrate and potassium nitrate, and of potassium nitrate, calcium nitrate and sodium nitrate.

  2. Fluidics: Basic components and applications

    NASA Astrophysics Data System (ADS)

    Joyce, J. W.

    1983-08-01

    Since its discovery at Harry Diamond Lab. in 1959, fluidics has gradually been developed into a viable technology. This report describes fluidic components and systems now in use or ready for use in many applications. The fluidic technology provides sensing, computing, and controlling functions with fluid power through interaction of fluid streams. Since fluidics can perform these functions without mechanical moving parts that will wear out, it has the advantages of simplicity and reliability. Other advantages are the low cost, environmental insensitivity, and safety of fluidic systems. Commercial applications of fluidics in the aerospace industry, include medicine, and personal-use items. The first aerospace application in production in the United States was for the thrust-reverser control for a DC-10 airplane. In industry, fluidics has been applied to air-conditioning controls, machine controls, process controls, and production-line controls. One of the first commercial applications of fluidics was for life-support medical equipment. For military use, fluidics has been successfully applied to a fluidic generator to convert pneumatic energy into electrical energy, a fluidic stability augmentation system for helicopters, and a pressure-regulating system for aircraft. Under development are rate sensing circuits for roll rate control of cannon-launched guided projectiles and missiles, and a fluidic capillary pyrometer for continuous temperature measurements in high-temperature process control.

  3. Bioactive Egg Components and Inflammation

    PubMed Central

    Andersen, Catherine J.

    2015-01-01

    Inflammation is a normal acute response of the immune system to pathogens and tissue injury. However, chronic inflammation is known to play a significant role in the pathophysiology of numerous chronic diseases, such as cardiovascular disease, type 2 diabetes mellitus, and cancer. Thus, the impact of dietary factors on inflammation may provide key insight into mitigating chronic disease risk. Eggs are recognized as a functional food that contain a variety of bioactive compounds that can influence pro- and anti-inflammatory pathways. Interestingly, the effects of egg consumption on inflammation varies across different populations, including those that are classified as healthy, overweight, metabolic syndrome, and type 2 diabetic. The following review will discuss the pro- and anti-inflammatory properties of egg components, with a focus on egg phospholipids, cholesterol, the carotenoids lutein and zeaxanthin, and bioactive proteins. The effects of egg consumption of inflammation across human populations will additionally be presented. Together, these findings have implications for population-specific dietary recommendations and chronic disease risk. PMID:26389951

  4. Electric vehicle drive train components

    SciTech Connect

    Silver, F.

    1994-12-31

    Power Control Systems has developed a family of electric vehicle drive systems that range from 65 horsepower through 300 horse power. These propulsion systems support vehicle applications ranging from light cars and pickups to buses and trucks weighing as much as 40,000 lbs (18,400 kg). These robust systems are designed specifically for automotive applications including safety, electromagnetic emissions, and environment ruggedness. Dolphin Drive Systems are very flexible. Their inverter controllers are programmable and can be provided as stand alone components matched to customer specified motors. A selection of pre-calibrated systems including motor and inverter/controller can be provided. Accessory tools are also available for customer self programming. Dolphin Drive Systems provide precision control of AC induction motors providing excellent torque-speed performance usually eliminating the need for multistage transmissions. In addition, they are very efficient over a wide speed/torque range. This provides for excellent power management over a variety of continuous speed and stop and go applications.

  5. Battery components employing a silicate binder

    DOEpatents

    Delnick, Frank M.; Reinhardt, Frederick W.; Odinek, Judy G.

    2011-05-24

    A battery component structure employing inorganic-silicate binders. In some embodiments, casting or coating of components may be performed using aqueous slurries of silicates and electrode materials or separator materials.

  6. Design of microstrip components by computer

    NASA Technical Reports Server (NTRS)

    Cisco, T. C.

    1972-01-01

    Development of computer programs for component analysis and design aids used in production of microstrip components is discussed. System includes designs for couplers, filters, circulators, transformers, power splitters, diode switches, and attenuators.

  7. 42 CFR 84.251 - Required components.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Required components. (a) Each vinyl chloride respirator described in § 84.250 shall, where its design...) Breathing tube. (b) The components of each vinyl chloride respirator shall meet the minimum...

  8. [Blood components and good practices in transfusion].

    PubMed

    Andreu, Georges

    2015-02-01

    Each year, more than three millions of blood components are transfused to more than five hundred thousand patients in France. The optimal use of blood components requires that physicians prescribing blood components master the clinical indications of red blood cells concentrates, platelet concentrates and fresh frozen plasma. In addition, physicians in charge of blood component prescription should provide adequate pre- and post-transfusion information to their patients. Compliance of blood components administration in patients with safety guidelines contributes as well to their optimal use. In addition, for each blood component transfused, a proper evaluation of its safety and its efficacy should be done. Finally, a regular evaluation of transfusion practice in hospital services were blood components are used, through audits made in cooperation with their blood component provider, either blood transfusion centre or the hospital blood bank, enables to appreciate the level of compliance with safety and clinical guidelines, and more globally how the transfusion process is mastered.

  9. Attitude Control Propulsion Components, Volume 2

    NASA Technical Reports Server (NTRS)

    1974-01-01

    Attitude control propulsion components are described, including hydrazine thrusters, hydrazine thruster and cold gas jet valves, and pressure and temperature transducers. Component-ordered data are presented in tabular form; the manufacturer and specific space program are included.

  10. Additive Manufacturing of Aerospace Propulsion Components

    NASA Technical Reports Server (NTRS)

    Misra, Ajay K.; Grady, Joseph E.; Carter, Robert

    2015-01-01

    The presentation will provide an overview of ongoing activities on additive manufacturing of aerospace propulsion components, which included rocket propulsion and gas turbine engines. Future opportunities on additive manufacturing of hybrid electric propulsion components will be discussed.

  11. Nonlinear principal component analysis of climate data

    SciTech Connect

    Boyle, J.; Sengupta, S.

    1995-06-01

    This paper presents the details of the nonlinear principal component analysis of climate data. Topic discussed include: connection with principal component analysis; network architecture; analysis of the standard routine (PRINC); and results.

  12. Explosive components facility certification tests

    SciTech Connect

    Dorrell, L.; Johnson, D.

    1995-08-01

    Sandia National Laboratories has recently completed construction of a new Explosive Components Facility (ECF) that will be used for the research and development of advanced explosives technology. The ECF includes nine indoor firing pads for detonating explosives and monitoring the detonations. Department of Energy requirements for certification of this facility include detonation of explosive levels up to 125 percent of the rated firing pad capacity with no visual structural degradation resulting from the explosion. The Explosives Projects and Diagnostics Department at Sandia decided to expand this certification process to include vibration and acoustic monitoring at various locations throughout the building during these explosive events. This information could then be used to help determine the best locations for noise and vibration sensitive equipment (e.g. scanning electron microscopes) used for analysis throughout the building. This facility has many unique isolation features built into the explosive chamber and laboratory areas of the building that allow normal operation of other building activities during explosive tests. This paper discusses the design of this facility and the various types of explosive testing performed by the Explosives Projects and Diagnostics Department at Sandia. However, the primary focus of the paper is directed at the vibration and acoustic data acquired during the certification process. This includes the vibration test setup and data acquisition parameters, as well as analysis methods used for generating peak acceleration levels and spectral information. Concerns over instrumentation issues such as the choice of transducers (appropriate ranges, resonant frequencies, etc.) and measurements with long cable lengths (500 feet) are also discussed.

  13. Indexing Mount For Rotation Of Optical Component

    NASA Technical Reports Server (NTRS)

    Reichle, Donald J., Jr.; Barnes, Norman P.

    1993-01-01

    Indexing mount for polarizer, wave plate, birefringent plate, or other optical component facilitates rotation of component to one or more preset angles. Includes hexagonal nut holding polarizer or other optical component. Ball bearing loaded by screw engages notch on cylindrical extension of nut engaging bracket. Time-consuming and tedious angular adjustment unnecessary: component turned quickly and easily, by hand or by use of wrench, to preset angular positions maintained by simple ball-detent mechanism.

  14. 42 CFR 93.209 - Funding component.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Funding component. 93.209 Section 93.209 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH... MISCONDUCT Definitions § 93.209 Funding component. Funding component means any organizational unit of the...

  15. 42 CFR 93.209 - Funding component.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Funding component. 93.209 Section 93.209 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH... MISCONDUCT Definitions § 93.209 Funding component. Funding component means any organizational unit of the...

  16. 42 CFR 93.209 - Funding component.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Funding component. 93.209 Section 93.209 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH... MISCONDUCT Definitions § 93.209 Funding component. Funding component means any organizational unit of the...

  17. 42 CFR 93.209 - Funding component.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Funding component. 93.209 Section 93.209 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH... MISCONDUCT Definitions § 93.209 Funding component. Funding component means any organizational unit of the...

  18. 6 CFR 7.11 - Components' responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Components' responsibilities. 7.11 Section 7.11 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION Administration § 7.11 Components' responsibilities. Each DHS component shall appoint a...

  19. Manufacturing complex silica aerogel target components

    SciTech Connect

    Defriend Obrey, Kimberly Ann; Day, Robert D; Espinoza, Brent F; Hatch, Doug; Patterson, Brian M; Feng, Shihai

    2008-01-01

    Aerogel is a material used in numerous components in High Energy Density Physics targets. In the past these components were molded into the proper shapes. Artifacts left in the parts from the molding process, such as contour irregularities from shrinkage and density gradients caused by the skin, have caused LANL to pursue machining as a way to make the components.

  20. Component separation of oceanic helium

    NASA Astrophysics Data System (ADS)

    Roether, Wolfgang; Well, Roland; Putzka, Alfred; Rüth, Christine

    1998-11-01

    A new procedure to quantify the components of oceanic helium ("terrigenic" 3He and 4He released from the ocean floor and "tritiugenic" 3He from tritium decay) is described. Terrigenic He and nonatmospheric 3He (i.e., terrigenic and tritiugenic combined) are obtained in terms of measured concentrations of the He isotopes and also of neon (Ne) (which improves the separation considerably), assuming terrigenic He to vanish in the mixed layer. For the subsequent separation of terrigenic and tritiugenic 3He, additional information is required and 3He due to natural tritium represents a complication. The procedure is applied to data from a hydrographic section in the South Atlantic (19°S, 1991) and one in the Eastern Mediterranean (1987). The 1σ data precisions and a systematic error accounting for uncertainties in mixed-layer He are approximately 0.3%. Sections of the new representations of oceanic He and 3He and comparisons to the nearest classical quantities (i.e., 3He, He) are presented. In the South Atlantic the 3He distribution reflects the hydrographic structure. East of 20°W the average 3He/4He ratio of terrigenic He below 800 m is 4.5±0.8 times the atmospheric ratio, which implies a substantial contribution of crustal He. In the upper waters, tritiugenic 3He (0.5 tritium units, ±20%) is separated from terrigenic 3He. In the Eastern Mediterranean, tritiugenic 3He is quantified throughout the water column in the presence of substantial levels of terrigenic He; the release rate of terrigenic He from the sea floor is found to be 3.1±1.2 1010 atoms m-2 s-1, similar to the rate for continental crust, with a mantle He contribution of 5±1.2% only. Recommendations for future work are to reduce the mentioned systematic error and the uncertainty margins of the He and Ne solubilities and of 3He due to natural tritium.

  1. Clean Diesel Component Improvement Program

    SciTech Connect

    2005-06-30

    The research conducted in this program significantly increased the knowledge and understanding in the fields of plasma physics and chemistry in diesel exhaust, the performance and characteristics of multifunctional catalysts in diesel exhaust, and the complexities of controlling a combination of such systems to remove NOx. Initially this program was designed to use an in-line plasma system (know as a plasma assisted catalyst system or PAC) to convert NO {yields} NO{sub 2}, a more catalytically active form of nitrogen oxides, and to crack hydrocarbons (diesel fuel in particular) into active species. The NO{sub 2} and the cracked hydrocarbons were then flowed over an in-line ceramic NOx catalyst that removed NO{sub 2} from the diesel exhaust. Even though the PAC system performed well technically and was able to remove over 95% of NOx from diesel exhaust the plasma component proved not to be practical or commercially feasible. The lack of practical and commercial viability was due to high unit costs and lack of robustness. The plasma system and its function was replaced in the NOx removal process by a cracking reforming catalyst that converted diesel fuel to a highly active reductant for NOx over a downstream ceramic NOx catalyst. This system was designated the ceramic catalyst system (CCS). It was also determined that NO conversion to NO{sub 2} was not required to achieve high levels of NOx reduction over ceramic NOx catalyst if that catalyst was properly formulated and the cracking reforming produced a reductant optimized for that NOx catalyst formulation. This system has demonstrated 92% NOx reduction in a diesel exhaust slipstream and 65% NOx reduction from the full exhaust of a 165 hp diesel engine using the FTP cycle. Although this system needs additional development to be commercial, it is simple, cost effective (does not use precious metals), sulfur tolerant, operates at high space velocities, does not require a second fluid be supplied as a reductant, has low

  2. Method of using infrared radiation for assembling a first component with a second component

    DOEpatents

    Sikka, Vinod K.; Whitson, Barry G.; Blue, Craig A.

    1999-01-01

    A method of assembling a first component for assembly with a second component involves a heating device which includes an enclosure having a cavity for inserting a first component. An array of infrared energy generators is disposed within the enclosure. At least a portion of the first component is inserted into the cavity, exposed to infrared energy and thereby heated to a temperature wherein the portion of the first component is sufficiently softened and/or expanded for assembly with a second component.

  3. Processing, testing and selecting blood components.

    PubMed

    Jones, Alister; Heyes, Jennifer

    Transfusion of blood components can be an essential and lifesaving treatment for many patients. However, components must comply with a number of national requirements to ensure they are safe and fit for use. Transfusion of incorrect blood components can lead to mortality and morbidity in patients, which is why patient testing and blood selection are important. This second article in our five-part series on blood transfusion outlines the requirements for different blood components, the importance of the ABO and RhD blood group systems and the processes that ensure the correct blood component is issued to each patient.

  4. Component Technology for Laser Plasma Simulation

    SciTech Connect

    Bosl, W J; Smith, S G; Dahlgren, T; Epperley, T; Kohn, S; Kumfert, G

    2002-06-17

    This paper will discuss the application of high performance component software technology developed for a complex physics simulation development effort. The primary tool used to build software components is called Babel and is used to create language-independent libraries for high performance computers. Components were constructed from legacy code and wrapped with a thin Python layer to enable run-time scripting. Low-level components in Fortran, C++, and Python were composed directly as Babel components and invoked interactively from a parallel Python script.

  5. Expandable Metal Liner For Downhole Components

    DOEpatents

    Hall, David R.; Fox, Joe R.

    2004-10-05

    A liner for an annular downhole component is comprised of an expandable metal tube having indentations along its surface. The indentations are formed in the wall of the tube either by drawing the tube through a die, by hydroforming, by stamping, or roll forming and may extend axially, radially, or spirally along its wall. The indentations accommodate radial and axial expansion of the tube within the downhole component. The tube is inserted into the annular component and deformed to match an inside surface of the component. The tube may be expanded using a hydroforming process or by drawing a mandrel through the tube. The tube may be expanded in such a manner so as to place it in compression against the inside wall of the component. The tube is useful for improving component hydraulics, shielding components from contamination, inhibiting corrosion, and preventing wear to the downhole component during use. It may also be useful for positioning conduit and insulated conductors within the component. An insulating material may be disposed between the tube and the component in order to prevent galvanic corrosion of the downhole component.

  6. Optical components damage parameters database system

    NASA Astrophysics Data System (ADS)

    Tao, Yizheng; Li, Xinglan; Jin, Yuquan; Xie, Dongmei; Tang, Dingyong

    2012-10-01

    Optical component is the key to large-scale laser device developed by one of its load capacity is directly related to the device output capacity indicators, load capacity depends on many factors. Through the optical components will damage parameters database load capacity factors of various digital, information technology, for the load capacity of optical components to provide a scientific basis for data support; use of business processes and model-driven approach, the establishment of component damage parameter information model and database systems, system application results that meet the injury test optical components business processes and data management requirements of damage parameters, component parameters of flexible, configurable system is simple, easy to use, improve the efficiency of the optical component damage test.

  7. Multiple-component covalent organic frameworks

    NASA Astrophysics Data System (ADS)

    Huang, Ning; Zhai, Lipeng; Coupry, Damien E.; Addicoat, Matthew A.; Okushita, Keiko; Nishimura, Katsuyuki; Heine, Thomas; Jiang, Donglin

    2016-07-01

    Covalent organic frameworks are a class of crystalline porous polymers that integrate molecular building blocks into periodic structures and are usually synthesized using two-component [1+1] condensation systems comprised of one knot and one linker. Here we report a general strategy based on multiple-component [1+2] and [1+3] condensation systems that enable the use of one knot and two or three linker units for the synthesis of hexagonal and tetragonal multiple-component covalent organic frameworks. Unlike two-component systems, multiple-component covalent organic frameworks feature asymmetric tiling of organic units into anisotropic skeletons and unusually shaped pores. This strategy not only expands the structural complexity of skeletons and pores but also greatly enhances their structural diversity. This synthetic platform is also widely applicable to multiple-component electron donor-acceptor systems, which lead to electronic properties that are not simply linear summations of those of the conventional [1+1] counterparts.

  8. Cold worked ferritic alloys and components

    DOEpatents

    Korenko, Michael K.

    1984-01-01

    This invention relates to liquid metal fast breeder reactor and steam generator precipitation hardening fully ferritic alloy components which have a microstructure substantially free of the primary precipitation hardening phase while having cells or arrays of dislocations of varying population densities. It also relates to the process by which these components are produced, which entails solution treating the alloy followed by a final cold working step. In this condition, the first significant precipitation hardening of the component occurs during high temperature use.

  9. NAC Aftermarket Brake Components Project (Secondary Items)

    DTIC Science & Technology

    2006-09-25

    NAC Aftermarket Brake Components Project (Secondary Items) SAE Paper #2006-01-3192 25 September 2006, Grapevine Version R4 (Final) Report...REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE NAC Aftermarket Brake Components Project (Secondary Items) 5a. CONTRACT NUMBER 5b...PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 NAC Aftermarket Brake Components Project By: Leo Miller, USA

  10. Monitoring Integrity Of Composite Aircraft Components

    NASA Technical Reports Server (NTRS)

    Tang, Shu Shing; Chen, Kuan-Luen; Kuo, An-Yu; Riccardella, Peter C.; Mucciardi, Anthony N.; Andrews, Robert J.; Grady, Joseph

    1994-01-01

    System developed that monitors integrity of composite-material structural components of aircraft in service. Includes strain gauges and accelerometers installed permanently in components to monitor vibrations, microprocessor-based data-acquisition system to process outputs of these vibration sensors, and desktop computer to analyze acquired data. By automating significant part of inspection process, system reduces amount of time needed for inspection and cost of inspection equipment. Contributes to safety by giving timely warning of hidden flaws that necessitate early, detailed inspection of critical components to determine whether components should be replaced immediately.

  11. Bocca : A development environment for HPC components.

    SciTech Connect

    Elwasif, W.; Norris, B.; Allan, B.; Armstrong, R.; Mathematics and Computer Science; ORNL; SNL

    2007-01-01

    In high-performance scientific software development, the emphasis is often on short time to first solution. Even when the development of new components mostly reuses existing components or libraries and only small amounts of new code must be created, dealing with component glue code to obtain complete applications is still tedious and error prone. Component-based software meant to reduce complexity at the application level increases complexity with the attendant glue code. To address these needs, we introduce Bocca, the first tool to enable application developers to perform rapid component prototyping while maintaining robust software engineering practices suitable to HPC environments. Bocca provides project management and a comprehensive build environment for creating and managing applications composed of Common Component Architecture components. Of critical importance for HPC applications, Bocca is designed to operate in a language-agnostic way, simultaneously handling components written in any of the common HPC workstation languages: C, C++, Fortran, Fortran77, Python, and Java. Bocca automates the tasks related to the component glue code, freeing the user to focus on the scientific aspects of the application. Bocca embraces the philosophy pioneered by Ruby Rails for web applications: Start with something that works and evolve it to the user's purpose.

  12. OCSEGen: Open Components and Systems Environment Generator

    NASA Technical Reports Server (NTRS)

    Tkachuk, Oksana

    2014-01-01

    To analyze a large system, one often needs to break it into smaller components.To analyze a component or unit under analysis, one needs to model its context of execution, called environment, which represents the components with which the unit interacts. Environment generation is a challenging problem, because the environment needs to be general enough to uncover unit errors, yet precise enough to make the analysis tractable. In this paper, we present a tool for automated environment generation for open components and systems. The tool, called OCSEGen, is implemented on top of the Soot framework. We present the tool's current support and discuss its possible future extensions.

  13. Bocca: A Development Environment for HPC Components

    SciTech Connect

    Elwasif, Wael R; Norris, Boyana; Benjamin, Allan A.; Armstrong, Robert C.

    2007-01-01

    In high-performance scientific software development, the emphasis is often on short time to first solution. Even when the development of new components mostly reuses existing components or libraries and only small amounts of new code must be created, dealing with the component glue code and software build processes to obtain complete applications is still tedious and error-prone. Component-based soft ware meant to reduce complexity at the application level increases complexity with the attendant glue code. To address these needs, we introduce Bocca, the first tool to enable application developers to perform rapid component prototyping while maintaining robust software-engineering practices suitable to HPC environments. Bocca provides project management and a comprehensive build environment for creating and managing applications composed of Common Component Architecture components. Of critical importance for HPC applications, Bocca is designed to operate in a language-agnostic way, simultaneously handling components written in any of the languages commonly used in scientific applications: C, C++, Fortran, Fortran77, Python, and Java. Bocca automates the tasks related to the component glue code, freeing the user to focus on the scientific aspects of the application. Bocca embraces the philosophy pioneered by Ruby Rails for web applications: Start with something that works and evolve it to the user's purpose.

  14. Effects of component length and of the transitions among components in multiple schedules1

    PubMed Central

    Hinson, John M.; Malone, John C.; McNally, Kathleen A.; Rowe, David W.

    1978-01-01

    Pigeons received equal variable-interval reinforcement during presentations of two line-orientation stimuli while five other orientations appeared in extinction. Component duration was 30 seconds for all orientations and the sequence was arranged so that each orientation preceded itself and each other orientation equally often. The duration of one component (0°) was shortened to 10 seconds and the other (90°) was lengthened to 50 seconds. All animals showed large increases in response rate in the shortened component and this increase was recoverable after an interpolated condition in which all components were again 30 seconds in duration. This effect was replicated in a second experiment in which component duration was changed from 150 seconds to 50 seconds and 250 seconds. An examination of local contrast effects during the first experiment showed that the shortened component produced local contrast during subsequent presentations of the lengthened component, just as would a component associated with more frequent reinforcement. When the presentation sequence was changed so that the lengthened component was always followed by the shortened component, response rates generally increased during the lengthened component. When the sequence was arranged so that the shortened component always preceded the longer component, response rate decreased in the former. These effects, as well as the increases in response rate following change in component length, seem not to be the product of local contrast effects among components. PMID:16812037

  15. Tweaking the Four-Component Model

    ERIC Educational Resources Information Center

    Curzer, Howard J.

    2014-01-01

    By maintaining that moral functioning depends upon four components (sensitivity, judgment, motivation, and character), the Neo-Kohlbergian account of moral functioning allows for uneven moral development within individuals. However, I argue that the four-component model does not go far enough. I offer a more accurate account of moral functioning…

  16. Densified edge seals for fuel cell components

    DOEpatents

    DeCasperis, Anthony J.; Roethlein, Richard J.; Breault, Richard D.

    1982-01-01

    A porous fuel cell component, such as an electrode substrate, has a densified edge which forms an improved gas seal during operation when soaked with electrolyte. The edges are made from the same composition as the rest of the component and are made by compressing an increased thickness of this material along the edges during the fabrication process.

  17. 21 CFR 890.5350 - Exercise component.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Exercise component. 890.5350 Section 890.5350 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Therapeutic Devices § 890.5350 Exercise component....

  18. 21 CFR 890.5350 - Exercise component.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Exercise component. 890.5350 Section 890.5350 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Therapeutic Devices § 890.5350 Exercise component....

  19. 21 CFR 890.5350 - Exercise component.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Exercise component. 890.5350 Section 890.5350 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Therapeutic Devices § 890.5350 Exercise component....

  20. Laser Velocimetry: The Elusive Third Component

    NASA Technical Reports Server (NTRS)

    Meyers, James F.

    1985-01-01

    The historical development of techniques for measuring three velocity components using laser velocimetry is presented. The techniques are described and their relative merits presented. Many of the approaches currently in use based on the fringe laser velocimeter have yielded inaccurate measurements of turbulence intensity in the on-axis component. A possible explanation for these inaccuracies is presented along with simulation results.

  1. Component Cost Analysis of Large Scale Systems

    NASA Technical Reports Server (NTRS)

    Skelton, R. E.; Yousuff, A.

    1982-01-01

    The ideas of cost decomposition is summarized to aid in the determination of the relative cost (or 'price') of each component of a linear dynamic system using quadratic performance criteria. In addition to the insights into system behavior that are afforded by such a component cost analysis CCA, these CCA ideas naturally lead to a theory for cost-equivalent realizations.

  2. Pedagogical Support Components of Students' Social Adaptation

    ERIC Educational Resources Information Center

    Vlasova, Vera K.; Simonova, Galina I.; Soleymani, Nassim

    2016-01-01

    The urgency of the problem stated in the article is caused by the need of pedagogical support of students' social adaptation on the basis of systematicity, which is achieved if we correctly define the components of the process. The aim of the article is to determine the pedagogical support components of students' social adaptation. The leading…

  3. The Components of Microbiological Risk Analysis.

    PubMed

    Liuzzo, Gaetano; Bentley, Stefano; Giacometti, Federica; Serraino, Andrea

    2015-02-03

    The paper describes the process of risk analysis in a food safety perspective. The steps of risk analysis defined as a process consisting of three interconnected components (risk assessment, risk management, and risk communication) are analysed. The different components of the risk assessment, risk management and risk communication are further described.

  4. Hybrid solar lighting systems and components

    DOEpatents

    Muhs, Jeffrey D.; Earl, Dennis D.; Beshears, David L.; Maxey, Lonnie C.; Jordan, John K.; Lind, Randall F.

    2007-06-12

    A hybrid solar lighting system and components having at least one hybrid solar concentrator, at least one fiber receiver, at least one hybrid luminaire, and a light distribution system operably connected to each hybrid solar concentrator and each hybrid luminaire. A controller operates each component.

  5. Hybrid solar lighting distribution systems and components

    DOEpatents

    Muhs, Jeffrey D.; Earl, Dennis D.; Beshears, David L.; Maxey, Lonnie C.; Jordan, John K.; Lind, Randall F.

    2011-07-05

    A hybrid solar lighting distribution system and components having at least one hybrid solar concentrator, at least one fiber receiver, at least one hybrid luminaire, and a light distribution system operably connected to each hybrid solar concentrator and each hybrid luminaire. A controller operates all components.

  6. 21 CFR 890.5350 - Exercise component.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Exercise component. 890.5350 Section 890.5350 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Therapeutic Devices § 890.5350 Exercise component....

  7. 21 CFR 890.5350 - Exercise component.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Exercise component. 890.5350 Section 890.5350 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Therapeutic Devices § 890.5350 Exercise component....

  8. Cognitive Components of Developmental Writing Skill

    ERIC Educational Resources Information Center

    Decker, Scott L.; Roberts, Alycia M.; Roberts, Kristin L.; Stafford, Allison L.; Eckert, Mark A.

    2016-01-01

    A significant number of studies have examined the cognitive components of basic academic skills, which has led to major changes in both teaching and early identification assessment practices. However, the majority of previous research has focused solely on reading. This study examines the cognitive components of academic writing skills across…

  9. Generalized Structured Component Analysis with Latent Interactions

    ERIC Educational Resources Information Center

    Hwang, Heungsun; Ho, Moon-Ho Ringo; Lee, Jonathan

    2010-01-01

    Generalized structured component analysis (GSCA) is a component-based approach to structural equation modeling. In practice, researchers may often be interested in examining the interaction effects of latent variables. However, GSCA has been geared only for the specification and testing of the main effects of variables. Thus, an extension of GSCA…

  10. 21 CFR 225.42 - Components.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Components. 225.42 Section 225.42 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Product Quality Control § 225.42 Components. (a)...

  11. Tribology and Mechanical Components Branch Overview

    NASA Technical Reports Server (NTRS)

    Handschuh, Robert F.

    2010-01-01

    An overview of NASA Glenn Research Center's Tribology & Mechanical Components Branch is provided. Work in space mechanisms, seals, oil-free turbomachinery, and mechanical components is presented. An overview of current research for these technology areas is contained in this overview.

  12. Nonlinear Principal Components Analysis: Introduction and Application

    ERIC Educational Resources Information Center

    Linting, Marielle; Meulman, Jacqueline J.; Groenen, Patrick J. F.; van der Koojj, Anita J.

    2007-01-01

    The authors provide a didactic treatment of nonlinear (categorical) principal components analysis (PCA). This method is the nonlinear equivalent of standard PCA and reduces the observed variables to a number of uncorrelated principal components. The most important advantages of nonlinear over linear PCA are that it incorporates nominal and ordinal…

  13. Bacteriostatic conformal coating for electronic components

    NASA Technical Reports Server (NTRS)

    Bland, C.; Le Doux, F. N.

    1967-01-01

    Coating for electronic components used in space applications has bacteriostatic qualities capable of hindering bacterial reproduction, both vegetative and sporulative viable microorganisms. It exhibits high electrical resistivity, a low outgassing rate, and is capable of restraining electronic components when subjected to mechanical vibrations.

  14. 32 CFR 651.34 - EA components.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 4 2014-07-01 2013-07-01 true EA components. 651.34 Section 651.34 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) ENVIRONMENTAL QUALITY ENVIRONMENTAL ANALYSIS OF ARMY ACTIONS (AR 200-2) Environmental Assessment § 651.34 EA components. EAs should...

  15. 32 CFR 651.34 - EA components.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 4 2012-07-01 2011-07-01 true EA components. 651.34 Section 651.34 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) ENVIRONMENTAL QUALITY ENVIRONMENTAL ANALYSIS OF ARMY ACTIONS (AR 200-2) Environmental Assessment § 651.34 EA components. EAs should...

  16. 32 CFR 651.34 - EA components.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false EA components. 651.34 Section 651.34 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) ENVIRONMENTAL QUALITY ENVIRONMENTAL ANALYSIS OF ARMY ACTIONS (AR 200-2) Environmental Assessment § 651.34 EA components. EAs should...

  17. 32 CFR 651.34 - EA components.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 4 2013-07-01 2013-07-01 false EA components. 651.34 Section 651.34 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) ENVIRONMENTAL QUALITY ENVIRONMENTAL ANALYSIS OF ARMY ACTIONS (AR 200-2) Environmental Assessment § 651.34 EA components. EAs should...

  18. Automated reuseable components system study results

    NASA Technical Reports Server (NTRS)

    Gilroy, Kathy

    1989-01-01

    The Automated Reusable Components System (ARCS) was developed under a Phase 1 Small Business Innovative Research (SBIR) contract for the U.S. Army CECOM. The objectives of the ARCS program were: (1) to investigate issues associated with automated reuse of software components, identify alternative approaches, and select promising technologies, and (2) to develop tools that support component classification and retrieval. The approach followed was to research emerging techniques and experimental applications associated with reusable software libraries, to investigate the more mature information retrieval technologies for applicability, and to investigate the applicability of specialized technologies to improve the effectiveness of a reusable component library. Various classification schemes and retrieval techniques were identified and evaluated for potential application in an automated library system for reusable components. Strategies for library organization and management, component submittal and storage, and component search and retrieval were developed. A prototype ARCS was built to demonstrate the feasibility of automating the reuse process. The prototype was created using a subset of the classification and retrieval techniques that were investigated. The demonstration system was exercised and evaluated using reusable Ada components selected from the public domain. A requirements specification for a production-quality ARCS was also developed.

  19. Statistical modeling of electrical components: Final report

    SciTech Connect

    Jolly, R.L.

    1988-07-01

    A method of forecasting production yields based on SPICE (University of California at Berkeley) circuit simulation and Monte Carlo techniques was evaluated. This method involved calculating functionally accurate component models using statistical techniques and using these component models in a SPICE electrical circuit simulation program. The results of the simulation program allow production yields to be calculated using standard statistical techniques.

  20. Reserve Component Programs, Fiscal Year 1988.

    DTIC Science & Technology

    1988-01-01

    factors for the Arm,’ reserve components and the Marine Corps Reserve is lack of military occupational -. specialty qualification. This problem is...components informed the Board of -what they perceive to be their most serious limiting factors to readiness in FY 1988. One of the most critical limiting

  1. Working Memory Components and Intelligence in Children

    ERIC Educational Resources Information Center

    Tillman, Carin M.; Nyberg, Lilianne; Bohlin, Gunilla

    2008-01-01

    This study investigated, in children aged 6-13 years, how different components of the working memory (WM) system (short-term storage and executive processes), within both verbal and visuospatial domains, relate to fluid intelligence. We also examined the degree of domain-specificity of the WM components as well as the differentiation of storage…

  2. Sandia_HighTemperatureComponentEvaluation_2015

    SciTech Connect

    Cashion, Avery T.

    2015-03-01

    The objective of this project is to perform independent evaluation of high temperature components to determine their suitability for use in high temperature geothermal tools. Development of high temperature components has been increasing rapidly due to demand from the high temperature oil and gas exploration and aerospace industries. Many of these new components are at the late prototype or first production stage of development and could benefit from third party evaluation of functionality and lifetime at elevated temperatures. In addition to independent testing of new components, this project recognizes that there is a paucity of commercial-off-the-shelf COTS components rated for geothermal temperatures. As such, high-temperature circuit designers often must dedicate considerable time and resources to determine if a component exists that they may be able to knead performance out of to meet their requirements. This project aids tool developers by characterization of select COTS component performances beyond published temperature specifications. The process for selecting components includes public announcements of project intent (e.g., FedBizOps), direct discussions with candidate manufacturers,and coordination with other DOE funded programs.

  3. The Components of Microbiological Risk Analysis

    PubMed Central

    Bentley, Stefano; Giacometti, Federica; Serraino, Andrea

    2015-01-01

    The paper describes the process of risk analysis in a food safety perspective. The steps of risk analysis defined as a process consisting of three interconnected components (risk assessment, risk management, and risk communication) are analysed. The different components of the risk assessment, risk management and risk communication are further described. PMID:27800384

  4. Flight service evaluation of composite helicopter components

    NASA Technical Reports Server (NTRS)

    Rich, M. J.; Lowry, D. W.

    1985-01-01

    An assessment of composite helicopter structures, exposed to environmental effects, after four years of commercial service is presented. This assessment is supported by test results of helicopter components and test panels which have been exposed to environmental effects since late 1979. Full scale static and fatigue tests are being conducted on composite components obtained from S-76 helicopters in commercial operations in the Gulf Coast region of Louisiana. Small scale tests are being conducted on coupons obtained from panels being exposed to outdoor conditions in Stratford, Connecticut and West Palm Beach, Florida. The panel layups represent S-76 components. Moisture evaluations and strength tests are being conducted, on the S-76 components and panels, over a period of eight years. Results are discussed for components and panels with up to four years of exposure.

  5. Assessing Component Effects in Formulation Systems

    SciTech Connect

    Snee, Ronald D.; Piepel, Gregory F.

    2012-12-17

    The purpose of Snee (2011) was to discuss and illustrate how using Six Sigma concepts and approaches can lead to a better understanding of formulation systems. Central to the recommended approach is estimating and interpreting the effects of the components in the formulation on the response variable. Knowledge of components that have no effect, small or large effects (positive or negative), and similar effects is very helpful in understanding how the formulation system works. This understanding helps one decide 1) which components having large effects should be increased or decreased, and 2) what to do about components with no effects or similar effects. Correspondence between the authors following Snee (2011), along with further review of the literature, have pointed out that the approaches discussed in Snee (2011), and the interpretation of component effects in general, need further clarification. That is the focus of this article.

  6. Hot gas path component cooling system

    DOEpatents

    Lacy, Benjamin Paul; Bunker, Ronald Scott; Itzel, Gary Michael

    2014-02-18

    A cooling system for a hot gas path component is disclosed. The cooling system may include a component layer and a cover layer. The component layer may include a first inner surface and a second outer surface. The second outer surface may define a plurality of channels. The component layer may further define a plurality of passages extending generally between the first inner surface and the second outer surface. Each of the plurality of channels may be fluidly connected to at least one of the plurality of passages. The cover layer may be situated adjacent the second outer surface of the component layer. The plurality of passages may be configured to flow a cooling medium to the plurality of channels and provide impingement cooling to the cover layer. The plurality of channels may be configured to flow cooling medium therethrough, cooling the cover layer.

  7. Emotional stability components of human performance problems

    SciTech Connect

    Wexler, R.H.

    1987-01-01

    Over half of all significant events that occur in nuclear plants involve human performance problems. There is increasing worldwide recognition that human performance problems have a significant impact on the safety, cost, and efficiency of nuclear plant operations. Emotional stability components have an important direct and indirect impact on human performance problems. This paper examines emotional stability components that are currently incorporated into human performance evaluation systems (HPES) in nuclear plants. It describes HPES programs being developed around the world, the emotional stability components that are currently referred to in these programs, and suggestions for improving HPES programs through a greater understanding of emotion stability components. A review of emotional stability components that may hinder or promote a plant environment that encourages the voluntary reporting and correction of human error is also presented.

  8. Child Disaster Mental Health Interventions: Therapy Components

    PubMed Central

    Pfefferbaum, Betty; Sweeton, Jennifer L.; Nitiéma, Pascal; Noffsinger, Mary A.; Varma, Vandana; Nelson, Summer D.; Newman, Elana

    2015-01-01

    Children face innumerable challenges following exposure to disasters. To address trauma sequelae, researchers and clinicians have developed a variety of mental health interventions. While the overall effectiveness of multiple interventions has been examined, few studies have focused on the individual components of these interventions. As a preliminary step to advancing intervention development and research, this literature review identifies and describes nine common components that comprise child disaster mental health interventions. This review concluded that future research should clearly define the constituent components included in available interventions. This will require that future studies dismantle interventions to examine the effectiveness of specific components and identify common therapeutic elements. Issues related to populations studied (eg, disaster exposure, demographic and cultural influences) and to intervention delivery (eg, timing and optimal sequencing of components) also warrant attention. PMID:25225954

  9. The "Yin" and "Yang" of Cell Cycle Progression and Differentiation in the Oligodendroglial Lineage

    ERIC Educational Resources Information Center

    Nguyen, Laurent; Borgs, Laurence; Vandenbosch, Renaud; Mangin, Jean-Marie; Beukelaers, Pierre; Moonen, Gustave; Gallo, Vittorio; Malgrange, Brigitte; Belachew, Shibeshih

    2006-01-01

    In white matter disorders such as leukodystrophies (LD), periventricular leucomalacia (PVL), or multiple sclerosis (MS), the hypomyelination or the remyelination failure by oligodendrocyte progenitor cells involves errors in the sequence of events that normally occur during development when progenitors proliferate, migrate through the white…

  10. FK506 treatment inhibits caspase-3 activation and promotes oligodendroglial survival following traumatic spinal cord injury.

    PubMed

    Nottingham, Stephanie; Knapp, Pamela; Springer, Joe

    2002-09-01

    The focus of this study is to examine the ability of FK506, an immunosuppressant that inhibits calcineurin activation, to limit caspase-3 activation in oligodendroglia following spinal cord injury (SCI). To better establish a role for calcineurin and caspase-3 activation in oligodendroglia following SCI, rats received a contusion injury to the spinal cord followed by treatment with FK506 or rapamycin (another immunosuppressant with no detectable inhibitory action on calcineurin activation). Animals were then sacrificed at 8 days postinjury and spinal cord tissue was processed using immunofluorescence histochemistry to examine cellular caspase-3 activation in ventral and dorsal white matter. In all treatment groups, numerous oligodendroglia were found to express the activated form of caspase-3 in regions proximal and distal to the injury epicenter. However, our findings suggest that treatment with FK506, but not rapamycin reduces the number of oligodendroglia expressing activated caspase-3 and increases the number of surviving oligodendroglia in dorsal white matter. These results provide initial evidence that agents that reduce the actions of calcineurin and subsequent caspase-3 activation may prove beneficial in the treatment of traumatic SCI.

  11. The role of chemotherapy for pure and mixed anaplastic oligodendroglial tumors.

    PubMed

    Dunbar, Erin M

    2009-08-01

    Pure and mixed anaplastic oligodendrogliomas (AO/mixed-AOs) remain terminal primary brain tumors, without a defined optimal initial therapy, and without sufficiently active and tolerable therapies at recurrence/progression (R/P). Very heterogeneous international therapy recommendations remain. Historical advances have resulted in only modest improvements in outcome. AO/mixed-AOs with 1p/19q co-deletion are prognostically favorable, regardless of therapy, and must be identified as early as possible. Following resection, outcome data on initial therapy with radiation (RT) remain the most mature, although controversies regarding its true toxicities and optimal timing continue. Recently, the landmark RTOG 9402 and EORTC 26951 trials showed that the addition of Procarbazine, CCNU, Vincristine chemotherapy to RT, at anytime during initial therapy, prolongs progression-free survival, but not survival, and not without moderate toxicity. Despite a lack of definitive evidence, this strategy has commonly been extrapolated to Temozolomide. Chemo-sensitivity of AO/mixed-AOs provides the rationale for the chemotherapy-only strategies being explored. In the setting of recurrence/progression (R/P), chemotherapy, small molecule (targeted), biologic, and other strategies have been relatively disappointing, toxic, and cumbersome. Partly secondary to biases regarding the relative toxicities of tumor burden vs. treatment effect, therapy remains highly individualized. Future international research must prospectively evaluate health-related quality of life, toxicity, and molecular genetic markers.

  12. Finding degrees of separation: Experimental approaches for astroglial and oligodendroglial cell isolation and genetic targeting

    PubMed Central

    Chew, Li-Jin; DeBoy, Cynthia A.; Senatorov, Vladimir V

    2014-01-01

    The study of CNS glial cell function requires experimental methods to detect, purify, and manipulate each cell population with fidelity and specificity. With the identification and cloning of cell- and stage-specific markers, glial cell analysis techniques have grown beyond physical methods of tissue dissociation and cell culture, and become highly specific with immunoselection of cell cultures in vitro and genetic targeting in vivo. The unique plasticity of glial cells offers the potential for cell replacement therapies in neurological disease that utilize neural cells derived from transplanted neural stem and progenitor cells. In this mini-review, we outline general physical and genetic approaches for macroglial cell generation. We summarize cell culture methods to obtain astrocytes and oligodendrocytes and their precursors, from developing and adult tissue, as well as approaches to obtain human neural progenitor cells through the establishment of stem cells. We discuss popular targeting rodent strains designed for cell-specific detection, selection and manipulation of neuroglial cell progenitors and their committed progeny. Based on shared markers between astrocytes and stem cells, we discuss genetically modified mouse strains with overlapping expression, and highlight SOX-expressing strains available for targeting of stem and progenitor cell populations. We also include recently established mouse strains for detection, and tag-assisted RNA and miRNA analysis. This discussion aims to provide a brief overview of the rapidly expanding collection of experimental approaches and genetic resources for the isolation and targeting of macroglial cells, their sources, progeny and gene products to facilitate our understanding of their properties and potential application in pathology. PMID:25169049

  13. The neuroprotective effect exerted by oligodendroglial progenitors on ischemically impaired hippocampal cells.

    PubMed

    Sypecka, Joanna; Sarnowska, Anna

    2014-04-01

    Oligodendrocyte progenitor cells (OPCs) are the focus of intense research for the purpose of cell replacement therapies in acquired or inherited neurodegenerative disorders, accompanied by ongoing hypo/demyelination. Recently, it has been postulated that these glia-committed cells exhibit certain properties of neural stem cells. Advances in stem cell biology have shown that their therapeutic effect could be attributed to their ability to secret numerous active compounds which modify the local microenvironment making it more susceptible to restorative processes. To verify this hypothesis, we set up an ex vivo co-culture system of OPCs isolated from neonatal rat brain with organotypic hippocampal slices (OHC) injured by oxygen-glucose deprivation (OGD). The presence of OPCs in such co-cultures resulted in a significant neuroprotective effect manifesting itself as a decrease in cell death rate and as an extension of newly formed cells in ischemically impaired hippocampal slices. A microarray analysis of broad spectrum of trophic factors and cytokines expressed by OPCs was performed for the purpose of finding the factor(s) contributing to the observed effect. Three of them-BDNF, IL-10 and SCF-were selected for the subsequent functional assays. Our data revealed that BDNF released by OPCs is the potent factor that stimulates cell proliferation and survival in OHC subjected to OGD injury. At the same time, it was observed that IL-10 attenuates inflammatory processes by promoting the formation of the cells associated with the immunological response. Those neuroprotective qualities of oligodendroglia-biased progenitors significantly contribute to anticipating a successful cell replacement therapy.

  14. Finding degrees of separation: experimental approaches for astroglial and oligodendroglial cell isolation and genetic targeting.

    PubMed

    Chew, Li-Jin; DeBoy, Cynthia A; Senatorov, Vladimir V

    2014-10-30

    The study of CNS glial cell function requires experimental methods to detect, purify, and manipulate each cell population with fidelity and specificity. With the identification and cloning of cell- and stage-specific markers, glial cell analysis techniques have grown beyond physical methods of tissue dissociation and cell culture, and become highly specific with immunoselection of cell cultures in vitro and genetic targeting in vivo. The unique plasticity of glial cells offers the potential for cell replacement therapies in neurological disease that utilize neural cells derived from transplanted neural stem and progenitor cells. In this mini-review, we outline general physical and genetic approaches for macroglial cell generation. We summarize cell culture methods to obtain astrocytes and oligodendrocytes and their precursors, from developing and adult tissue, as well as approaches to obtain human neural progenitor cells through the establishment of stem cells. We discuss popular targeting rodent strains designed for cell-specific detection, selection and manipulation of neuroglial cell progenitors and their committed progeny. Based on shared markers between astrocytes and stem cells, we discuss genetically modified mouse strains with overlapping expression, and highlight SOX-expressing strains available for targeting of stem and progenitor cell populations. We also include recently established mouse strains for detection, and tag-assisted RNA and miRNA analysis. This discussion aims to provide a brief overview of the rapidly expanding collection of experimental approaches and genetic resources for the isolation and targeting of macroglial cells, their sources, progeny and gene products to facilitate our understanding of their properties and potential application in pathology.

  15. Oligodendroglial response to ionizing radiation: Dose and dose-rate response

    SciTech Connect

    Levy, R.P.

    1991-12-01

    An in vitro system using neuroglia from neonatal rat brain was developed to examine the morphologic, immunocytochemical and biochemical response of oligodendroglia to ionizing radiation. Following acute {gamma}-irradiation at day-in-culture (DIC) 8, oligodendrocyte counts at DIC 14 were 55% to 65% of control values after 2 Gy, and 29% to 36% after 5 Gy. Counts increased to near-normal levels at DIC 21 in the 2 Gy group and to 75% of normal in the 5 Gy group. Myelin basic protein levels (MBP) at DIC 14 were 60% of control values after 2 Gy, and 40% after 5 Gy. At DIC 21, MBP after 2 Gy was 45% greater than that observed at DIC 14, but MBP, as a fraction of age-matched control values, dropped from 60% to 50%. Following 5 Gy, absolute MBP changed little between DIC 14 and DIC 21, but decreased from 40% to 25% of control cultures. The response to split-dose irradiation indicated that nearly all sublethal damage in the oligodendrocyte population (and its precursors) was repaired within 3 h to 4 h. A new compartmental cell model for radiation response in vitro of the oligodendrocyte population is proposed and examined in relation to the potential reaction to radiation injury in the brain.

  16. Mechanical properties determination of AM components

    NASA Astrophysics Data System (ADS)

    Dzugan, J.; Sibr, M.; Konopík, P.; Procházka, R.; Rund, M.

    2017-02-01

    Characterisation of engineering materials and components is a crucial part for design and save service life utilization. Due to components processing technologies and exploitation conditions local properties can significantly vary from location to location over larger components as well as over small material volumes with gradual material changes such as welds, coatings or additively manufactured parts. The current paper is dealing with local properties characterisation for additively manufacture (AM) components by micro tensile test (M-TT). Components produced by additive manufacturing techniques yield properties variation in dependence of the considered location within the component regarding to direction in relation to deposition process. Properties vary over the thickness, length, angle or contacts with the supporting structures necessary for a successful components production by additive manufacturing techniques. The properties differences are mainly related to varying heating/reheating and cooling conditions at various locations of usually very complex parts produced mainly by these technologies. The standard testing procedures fail to characterize such local properties of complex shaped objects due to large size requirements on specimens. Therefore, new techniques have to be established for such detailed local characterizations. Results of miniaturized tensile tests application for local properties and orientations are shown here.

  17. Component Database for the APS Upgrade

    SciTech Connect

    Veseli, S.; Arnold, N. D.; Jarosz, D. P.; Carwardine, J.; Decker, G.; Schwarz, N.

    2016-01-01

    The Advanced Photon Source Upgrade (APS-U) project will replace the existing APS storage ring with a multi-bend achromat (MBA) lattice to provide extreme transverse coherence and extreme brightness x-rays to its users. As the time to replace the existing storage ring accelerator is of critical concern, an aggressive one-year removal/installation/testing period is being planned. To aid in the management of the thousands of components to be installed in such a short time, the Component Database (CDB) application is being developed with the purpose to identify, document, track, locate, and organize components in a central database. Three major domains are being addressed: Component definitions (which together make up an exhaustive "Component Catalog"), Designs (groupings of components to create subsystems), and Component Instances (“Inventory”). Relationships between the major domains offer additional "system knowledge" to be captured that will be leveraged with future tools and applications. It is imperative to provide sub-system engineers with a functional application early in the machine design cycle. Topics discussed in this paper include the initial design and deployment of CDB, as well as future development plans.

  18. Symbiotic two-component gap solitons.

    PubMed

    Roeksabutr, Athikom; Mayteevarunyoo, Thawatchai; Malomed, Boris A

    2012-10-22

    We consider a two-component one-dimensional model of gap solitons (GSs), which is based on two nonlinear Schrödinger equations, coupled by repulsive XPM (cross-phase-modulation) terms, in the absence of the SPM (self-phase-modulation) nonlinearity. The equations include a periodic potential acting on both components, thus giving rise to GSs of the "symbiotic" type, which exist solely due to the repulsive interaction between the two components. The model may be implemented for "holographic solitons" in optics, and in binary bosonic or fermionic gases trapped in the optical lattice. Fundamental symbiotic GSs are constructed, and their stability is investigated, in the first two finite bandgaps of the underlying spectrum. Symmetric solitons are destabilized, including their entire family in the second bandgap, by symmetry-breaking perturbations above a critical value of the total power. Asymmetric solitons of intra-gap and inter-gap types are studied too, with the propagation constants of the two components falling into the same or different bandgaps, respectively. The increase of the asymmetry between the components leads to shrinkage of the stability areas of the GSs. Inter-gap GSs are stable only in a strongly asymmetric form, in which the first-bandgap component is a dominating one. Intra-gap solitons are unstable in the second bandgap. Unstable two-component GSs are transformed into persistent breathers. In addition to systematic numerical considerations, analytical results are obtained by means of an extended ("tailed") Thomas-Fermi approximation (TFA).

  19. Advanced Electrical Materials and Components Being Developed

    NASA Technical Reports Server (NTRS)

    Schwarze, Gene E.

    2004-01-01

    All aerospace systems require power management and distribution (PMAD) between the energy and power source and the loads. The PMAD subsystem can be broadly described as the conditioning and control of unregulated power from the energy source and its transmission to a power bus for distribution to the intended loads. All power and control circuits for PMAD require electrical components for switching, energy storage, voltage-to-current transformation, filtering, regulation, protection, and isolation. Advanced electrical materials and component development technology is a key technology to increasing the power density, efficiency, reliability, and operating temperature of the PMAD. The primary means to develop advanced electrical components is to develop new and/or significantly improved electronic materials for capacitors, magnetic components, and semiconductor switches and diodes. The next important step is to develop the processing techniques to fabricate electrical and electronic components that exceed the specifications of presently available state-of-the-art components. The NASA Glenn Research Center's advanced electrical materials and component development technology task is focused on the following three areas: 1) New and/or improved dielectric materials for the development of power capacitors with increased capacitance volumetric efficiency, energy density, and operating temperature; 2) New and/or improved high-frequency, high-temperature soft magnetic materials for the development of transformers and inductors with increased power density, energy density, electrical efficiency, and operating temperature; 3) Packaged high-temperature, high-power density, high-voltage, and low-loss SiC diodes and switches.

  20. The Component-Based Application for GAMESS

    SciTech Connect

    Peng, Fang

    2007-01-01

    GAMESS, a quantum chetnistry program for electronic structure calculations, has been freely shared by high-performance application scientists for over twenty years. It provides a rich set of functionalities and can be run on a variety of parallel platforms through a distributed data interface. While a chemistry computation is sophisticated and hard to develop, the resource sharing among different chemistry packages will accelerate the development of new computations and encourage the cooperation of scientists from universities and laboratories. Common Component Architecture (CCA) offers an enviromnent that allows scientific packages to dynamically interact with each other through components, which enable dynamic coupling of GAMESS with other chetnistry packages, such as MPQC and NWChem. Conceptually, a cotnputation can be constructed with "plug-and-play" components from scientific packages and require more than componentizing functions/subroutines of interest, especially for large-scale scientific packages with a long development history. In this research, we present our efforts to construct cotnponents for GAMESS that conform to the CCA specification. The goal is to enable the fine-grained interoperability between three quantum chemistry programs, GAMESS, MPQC and NWChem, via components. We focus on one of the three packages, GAMESS; delineate the structure of GAMESS computations, followed by our approaches to its component development. Then we use GAMESS as the driver to interoperate integral components from the other tw"o packages, arid show the solutions for interoperability problems along with preliminary results. To justify the versatility of the design, the Tuning and Analysis Utility (TAU) components have been coupled with GAMESS and its components, so that the performance of GAMESS and its components may be analyzed for a wide range of systetn parameters.

  1. Composing simulations using persistent software components

    SciTech Connect

    Holland, J.V.; Michelsen, R.E.; Powell, D.R.; Upton, S.C.; Thompson, D.R.

    1999-03-01

    The traditional process for developing large-scale simulations is cumbersome, time consuming, costly, and in some cases, inadequate. The topics of software components and component-based software engineering are being explored by software professionals in academic and industrial settings. A component is a well-delineated, relatively independent, and replaceable part of a software system that performs a specific function. Many researchers have addressed the potential to derive a component-based approach to simulations in general, and a few have focused on military simulations in particular. In a component-based approach, functional or logical blocks of the simulation entities are represented as coherent collections of components satisfying explicitly defined interface requirements. A simulation is a top-level aggregate comprised of a collection of components that interact with each other in the context of a simulated environment. A component may represent a simulation artifact, an agent, or any entity that can generated events affecting itself, other simulated entities, or the state of the system. The component-based approach promotes code reuse, contributes to reducing time spent validating or verifying models, and promises to reduce the cost of development while still delivering tailored simulations specific to analysis questions. The Integrated Virtual Environment for Simulation (IVES) is a composition-centered framework to achieve this potential. IVES is a Java implementation of simulation composition concepts developed at Los Alamos National Laboratory for use in several application domains. In this paper, its use in the military domain is demonstrated via the simulation of dismounted infantry in an urban environment.

  2. Interpreting principal components in biomechanics: representative extremes and single component reconstruction.

    PubMed

    Brandon, Scott C E; Graham, Ryan B; Almosnino, Sivan; Sadler, Erin M; Stevenson, Joan M; Deluzio, Kevin J

    2013-12-01

    Principal component analysis is a powerful tool in biomechanics for reducing complex multivariate datasets to a subset of important parameters. However, interpreting the biomechanical meaning of these parameters can be a subjective process. Biomechanical interpretations that are based on visual inspection of extreme 5th and 95th percentile waveforms may be confounded when extreme waveforms express more than one biomechanical feature. This study compares interpretation of principal components using representative extremes with a recently developed method, called single component reconstruction, which provides an uncontaminated visualization of each individual biomechanical feature. Example datasets from knee joint moments, lateral gastrocnemius EMG, and lumbar spine kinematics are used to demonstrate that the representative extremes method and single component reconstruction can yield equivalent interpretations of principal components. However, single component reconstruction interpretation cannot be contaminated by other components, which may enhance the use and understanding of principal component analysis within the biomechanics community.

  3. NHI Component Technical Readiness Evaluation System

    SciTech Connect

    Steven R. Sherman; Dane F. Wilson; Steven J. Pawel

    2007-09-01

    A decision process for evaluating the technical readiness or maturity of components (i.e., heat exchangers, chemical reactors, valves, etc.) for use by the U.S. DOE Nuclear Hydrogen Initiative is described. This system is used by the DOE NHI to assess individual components in relation to their readiness for pilot-scale and larger-scale deployment and to drive the research and development work needed to attain technical maturity. A description of the evaluation system is provided, and examples are given to illustrate how it is used to assist in component R&D decisions.

  4. Description of the RDCDS Meteorological Component

    SciTech Connect

    Pekour, Mikhail S.; Berg, Larry K.

    2007-10-01

    This report provides a detailed description of the Rapidly Deployable Chemical Defense System (RDCDS) Meteorological Component. The Meteorological Component includes four surface meteorological stations, miniSODAR, laptop computers, and communications equipment. This report describes the equipment that is used, explains the operation of the network, and gives instructions for setting up the Component and replacing defective parts. A detailed description of operation and use of the individual sensors, including the data loggers is not covered in the current document, and the interested reader should refer to the manufacturer’s documentation.

  5. A Linguistic Model in Component Oriented Programming

    NASA Astrophysics Data System (ADS)

    Crăciunean, Daniel Cristian; Crăciunean, Vasile

    2016-12-01

    It is a fact that the component-oriented programming, well organized, can bring a large increase in efficiency in the development of large software systems. This paper proposes a model for building software systems by assembling components that can operate independently of each other. The model is based on a computing environment that runs parallel and distributed applications. This paper introduces concepts as: abstract aggregation scheme and aggregation application. Basically, an aggregation application is an application that is obtained by combining corresponding components. In our model an aggregation application is a word in a language.

  6. Downhole component with a pressure equalization passageway

    DOEpatents

    Hall, David R.; Pixton, David S.; Dahlgren, Scott; Reynolds, Jay T.; Breihan, James W.; Briscoe, Michael A.

    2006-08-22

    The present invention includes a downhole component adapted for transmitting downhole data. The downhole component includes a threaded end on a downhole component. The threaded end furthermore includes an interior region, and exterior region, and a mating surface wherein a cavity is formed. A data transmission element is disposed in the cavity and displaces a volume of the cavity. At least one passageway is formed in the threaded region between interior and exterior regions. The passageway is in fluid communication with both the interior and exterior regions and thereby relieves pressure build up of thread lubricant upon tool joint make up.

  7. LDEF active optical system components experiment

    NASA Technical Reports Server (NTRS)

    Blue, M. D.

    1991-01-01

    A preliminary report on the Active Optical System Components Experiment is presented. This experiment contained 136 components in a six-inch deep tray including lasers, infrared detectors and arrays, ultraviolet light detectors, light-emitting diodes, a light modulator, flash lamps, optical filters, glasses, and samples of surface finishes. The experimental results for those component characteristics appear as much related to the passage of time as to the effects of the space environment, but organic materials and extreme-infrared reflectivity of black paints show unexpected changes.

  8. LDEF active optical system components experiment

    NASA Technical Reports Server (NTRS)

    Blue, M. D.

    1992-01-01

    A preliminary report on the Active Optical System Components Experiment is presented. This experiment contained 136 components in a six inch deep tray including lasers, infrared detectors and arrays, ultraviolet light detectors, light-emitting diodes, a light modulator, flash lamps, optical filters, glasses, and samples of surface finishes. Thermal, mechanical, and structural considerations leading to the design of the tray hardware are discussed. In general, changes in the retested component characteristics appear as much related to the passage of time as to the effects of the space environment, but organic materials, multilayer optical interference filters, and extreme-infrared reflectivity of black paints show unexpected changes.

  9. Attitude Control Propulsion Components, Volume 1

    NASA Technical Reports Server (NTRS)

    1974-01-01

    Effort was made to include as much engineering information on each component as possible, consistent with usefulness and catalog size limitations. The contents of this catalog contain components which were qualified for use with spacecraft monopropellant hydrazine and inert gas attitude control systems. Thrust ranges up to 44.5 N (10.0 lbf) for hydrazine and inert gas sytems were considered. Additionally, some components qualified for uses other than spacecraft attitude control are included because they are suitable for use in attitude controls systems.

  10. Perceptual-components architecture for digital video

    NASA Technical Reports Server (NTRS)

    Watson, Andrew B.

    1990-01-01

    A perceptual-components architecture for digital video partitions the image stream into signal components in a manner analogous to that used in the human visual system. These components consist of achromatic and opponent color channels, divided into static and motion channels, further divided into bands of particular spatial frequency and orientation. Bits are allocated to an individual band in accord with visual sensitivity to that band and in accord with the properties of visual masking. This architecture is argued to have desirable features such as efficiency, error tolerance, scalability, device independence, and extensibility.

  11. Advanced Electrical Materials and Component Development

    NASA Technical Reports Server (NTRS)

    Schwarze, Gene E.

    2003-01-01

    The primary means to develop advanced electrical components is to develop new and improved materials for magnetic components (transformers, inductors, etc.), capacitors, and semiconductor switches and diodes. This paper will give a description and status of the internal and external research sponsored by NASA Glenn Research Center on soft magnetic materials, dielectric materials and capacitors, and high quality silicon carbide (SiC) atomically smooth substrates. The rationale for and the benefits of developing advanced electrical materials and components for the PMAD subsystem and also for the total power system will be briefly discussed.

  12. Flight service evaluation of composite helicopter components

    NASA Technical Reports Server (NTRS)

    Mardoian, G. H.; Ezzo, M. B.

    1986-01-01

    This report presents an assessment of composite helicopter tail rotor spars and horizontal stabilizers, exposed to the effects of the environment, after up to five and a half years of commercial service. This evaluation is supported by test results of helicopter components and panels which have been exposed to outdoor environmental effects since September 1979. Full scale static and fatigue tests have been conducted on graphite/epoxy and Kevlar/epoxy composite components obtained from Sikorsky Model S-76 helicopters in commercial operations in the Gulf Coast region of Louisiana. Small scale static and fatigue tests are being conducted on coupons obtained from panels under exposure to outdoor conditions in Stratford, Connecticut and West Palm, Florida. The panel layups are representative of the S-76 components. Additionally, this report discusses the results of moisture absorption evaluations and strength tests on the S-76 components and composite panels with up to five years of outdoor exposure.

  13. Crystallization in two-component Coulomb systems.

    PubMed

    Bonitz, M; Filinov, V S; Fortov, V E; Levashov, P R; Fehske, H

    2005-12-02

    The analysis of Coulomb crystallization is extended from one-component to two-component plasmas. Critical parameters for the existence of Coulomb crystals are derived for both classical and quantum crystals. In the latter case, a critical mass ratio of the two charged components is found, which is of the order of 80. Thus, holes in semiconductors with sufficiently flat valence bands are predicted to spontaneously order into a regular lattice. Such hole crystals are intimately related to ion Coulomb crystals in white dwarf and neutron stars as well as to ion crystals produced in the laboratory. A unified phase diagram of two-component Coulomb crystals is presented and is verified by first-principles computer simulations.

  14. Genetics Home Reference: complement component 8 deficiency

    MedlinePlus

    ... the membranes surrounding the brain and spinal cord (meningitis). Although meningitis can be life-threatening, individuals with complement component ... leaves affected individuals prone to recurrent episodes of meningitis. Learn more about the genes associated with complement ...

  15. Data transmission element for downhole drilling components

    DOEpatents

    Hall, David R.; Hall, Jr., H. Tracy; Pixton, David S.; Dahlgren, Scott; Fox, Joe; Sneddon, Cameron; Briscoe, Michael

    2006-01-31

    A robust data transmission element for transmitting information between downhole components, such as sections of drill pipe, in the presence of hostile environmental conditions, such as heat, dirt, rocks, mud, fluids, lubricants, and the like. The data transmission element components include a generally U-shaped annular housing, a generally U-shaped magnetically conductive, electrically insulating element such as ferrite, and an insulated conductor. Features on the magnetically conducting, electrically insulating element and the annular housing create a pocket when assembled. The data transmission element is filled with a polymer to retain the components within the annular housing by filling the pocket with the polymer. The polymer can bond with the annular housing and the insulated conductor but preferably not the magnetically conductive, electrically insulating element. A data transmission element is mounted within a recess proximate a mating surface of a downhole drilling component, such as a section of drill pipe.

  16. CHEMICAL ANALYSIS METHODS FOR ATMOSPHERIC AEROSOL COMPONENTS

    EPA Science Inventory

    This chapter surveys the analytical techniques used to determine the concentrations of aerosol mass and its chemical components. The techniques surveyed include mass, major ions (sulfate, nitrate, ammonium), organic carbon, elemental carbon, and trace elements. As reported in...

  17. Silicon Micromachining for Terahertz Component Development

    NASA Technical Reports Server (NTRS)

    Chattopadhyay, Goutam; Reck, Theodore J.; Jung-Kubiak, Cecile; Siles, Jose V.; Lee, Choonsup; Lin, Robert; Mehdi, Imran

    2013-01-01

    Waveguide component technology at terahertz frequencies has come of age in recent years. Essential components such as ortho-mode transducers (OMT), quadrature hybrids, filters, and others for high performance system development were either impossible to build or too difficult to fabricate with traditional machining techniques. With micromachining of silicon wafers coated with sputtered gold it is now possible to fabricate and test these waveguide components. Using a highly optimized Deep Reactive Ion Etching (DRIE) process, we are now able to fabricate silicon micromachined waveguide structures working beyond 1 THz. In this paper, we describe in detail our approach of design, fabrication, and measurement of silicon micromachined waveguide components and report the results of a 1 THz canonical E-plane filter.

  18. Photovoltaics: Basic Design Principles and Components

    SciTech Connect

    1997-03-01

    This publication will introduce you to the basic design principles and components of PV systems. It will also help you discuss these systems knowledgeably with an equipment supplier or system installer.

  19. Remembering Components of Food in Drosophila

    PubMed Central

    Das, Gaurav; Lin, Suewei; Waddell, Scott

    2016-01-01

    Remembering features of past feeding experience can refine foraging and food choice. Insects can learn to associate sensory cues with components of food, such as sugars, amino acids, water, salt, alcohol, toxins and pathogens. In the fruit fly Drosophila some food components activate unique subsets of dopaminergic neurons (DANs) that innervate distinct functional zones on the mushroom bodies (MBs). This architecture suggests that the overall dopaminergic neuron population could provide a potential cellular substrate through which the fly might learn to value a variety of food components. In addition, such an arrangement predicts that individual component memories reside in unique locations. DANs are also critical for food memory consolidation and deprivation-state dependent motivational control of the expression of food-relevant memories. Here, we review our current knowledge of how nutrient-specific memories are formed, consolidated and specifically retrieved in insects, with a particular emphasis on Drosophila. PMID:26924969

  20. High power, high frequency component test facility

    NASA Technical Reports Server (NTRS)

    Roth, Mary Ellen; Krawczonek, Walter

    1990-01-01

    The NASA Lewis Research Center has available a high frequency, high power laboratory facility for testing various components of aerospace and/or terrestrial power systems. This facility is described here. All of its capabilities and potential applications are detailed.

  1. Chiral Chlordane Components in Environmental Matrices

    EPA Science Inventory

    Chlordane, a persistent, bioaccumulative and toxic organochlorine pesticide, has been studied for many years. Since the advent of chiral analysis for environmental samples, over 2,400 measurements have been made of various chiral chlordane components. Chlordane enantiomer fractio...

  2. Analysis of failed nuclear plant components

    SciTech Connect

    Diercks, D.R.

    1992-07-01

    Argonne National Laboratory has conducted analyses of failed components from nuclear power generating stations since 1974. The considerations involved in working with and analyzing radioactive components are reviewed here, and the decontamination of these components is discussed. Analyses of four failed components from nuclear plants are then described to illustrate the kinds of failures seen in service. The failures discussed are (a) intergranular stress corrosion cracking of core spray injection piping in a boiling water reactor, (b) failure of canopy seal welds in adapter tube assemblies in the control rod drive head of a pressure water reactor, (c) thermal fatigue of a recirculation pump shaft in a boiling water reactor, and (d) failure of pump seal wear rings by nickel leaching in a boiling water reactor.

  3. Thermochemical nanolithography components, systems, and methods

    DOEpatents

    Riedo, Elisa; Marder, Seth R.; de Heer, Walt A.; Szoskiewicz, Robert J.; Kodali, Vamsi K.; Jones, Simon C.; Okada, Takashi; Wang, Debin; Curtis, Jennifer E.; Henderson, Clifford L.; Hua, Yueming

    2013-06-18

    Improved nanolithography components, systems, and methods are described herein. The systems and methods generally employ a resistively heated atomic force microscope tip to thermally induce a chemical change in a surface. In addition, certain polymeric compositions are also disclosed.

  4. Hydrodynamic design of generic pump components

    NASA Technical Reports Server (NTRS)

    Eastland, A. H. J.; Dodson, H. C.

    1991-01-01

    Inducer and impellar base geometries were defined for a fuel pump for a generic generator cycle. Blade surface data and inlet flowfield definition are available in sufficient detail to allow computational fluid dynamic analysis of the two components.

  5. Middleware for dynamic adaptation of component applications.

    SciTech Connect

    Norris, B.; Bhowmick, S.; Kaushik, D.; McInnes, L. C.

    2007-01-01

    Component- and service-based software engineering approaches have been gaining popularity in high-performance scientific computing, facilitating the creation and management of large multidisciplinary, multideveloper applications, and providing opportunities for improved performance and numerical accuracy. These software engineering approaches enable the development of middleware infrastructure for computational quality of service (CQoS), which provides performance optimizations through dynamic algorithm selection and configuration in a mostly automated fashion. The factors that affect performance are closely tied to a component's parallel implementation, its management of parallel communication and memory, the algorithms executed, the algorithmic parameters employed, and other operational characteristics. We present the design of a component middleware CQoS architecture for automated composition and adaptation of high-performance component- or service-based applications. We describe its initial implementation and corresponding experimental results for parallel simulations involving time-dependent nonlinear partial differential equations.

  6. Systems and methods for measuring component matching

    NASA Technical Reports Server (NTRS)

    Courter, Kelly J. (Inventor); Slenk, Joel E. (Inventor)

    2006-01-01

    Systems and methods for measuring a contour match between adjacent components are disclosed. In one embodiment, at least two pressure sensors are located between adjacent components. Each pressure sensor is adapted to obtain a pressure measurement at a location a predetermined distance away from the other pressure sensors, and to output a pressure measurement for each sensor location. An output device is adapted to receive the pressure measurements from at least two pressure sensors and display the pressure measurements. In one aspect, the pressure sensors include flexible thin film pressure sensors. In accordance with other aspects of the invention, a method is provided for measuring a contour match between two interfacing components including measuring at least one pressure applied to at least one sensor between the interfacing components.

  7. Decontamination of large components-test case

    SciTech Connect

    Mancini, A.; Bosco, B.

    1996-12-31

    The rising per-cubic-foot burial costs, together with the trend toward standardized above-ground burial sites, provides the basis for seeking an alternative to direct burial of large components. Large contaminated components such as steam generators can be safely dismantled and decontaminated for free release, metals recycle, and volume reduction. This grand-scale disposal technology will prove to be an economical and ecological alternative to direct burial or interim storage. Yankee Atomic Electric Company (YAEC) in Bolton, operators and decommissioners of the Yankee Nuclear Power Station in Rowe, Massachusetts, has teamed with Frank W Hake Associates in Memphis, TN, to decontaminate a large component as a test case. The large component is YAEC`s reactor pressure vessel head (RPVH). The 79 100 lb RPVH is surface contaminated with 0.7 Ci (1500 mR/h contact) resulting from 32 yr of operating in a 2000 psi, 530{degrees}F pressurized water reactor environment.

  8. Stationary turbine component with laminated skin

    DOEpatents

    James, Allister W [Orlando, FL

    2012-08-14

    A stationary turbine engine component, such as a turbine vane, includes a internal spar and an external skin. The internal spar is made of a plurality of spar laminates, and the external skin is made of a plurality of skin laminates. The plurality of skin laminates interlockingly engage the plurality of spar laminates such that the external skin is located and held in place. This arrangement allows alternative high temperature materials to be used on turbine engine components in areas where their properties are needed without having to make the entire component out of such material. Thus, the manufacturing difficulties associated with making an entire component of such a material and the attendant high costs are avoided. The skin laminates can be made of advanced generation single crystal superalloys, intermetallics and refractory alloys.

  9. Estimating the PNF of Internal Satellite Components

    NASA Astrophysics Data System (ADS)

    Evans, Leanne; Winterboer, Arne

    2013-08-01

    As a consequence of the debris environment and its growing severity, the quantification of the risk posed to a satellite and its mission is becoming more desired not only from space agencies but also from satellite manufacturers. This paper looks into the use of ESABASE and how it can be used to assess the probability of no penetration (PNP) of a satellite's internal components, providing a more representative probability of no failure (PNF) of the entire satellite and the actual risk imposed on the mission. This improved modelling and analysis methodology increases the knowledge of which areas are the most vulnerable by considering component failures and not just the number of impacts or perforations of the structure walls. This information can then be used for assessing different mitigation measures, whether it is relocating the component, thickening the component walls or implementing additional shielding.

  10. Fast deterministic algorithm for EEE components classification

    NASA Astrophysics Data System (ADS)

    Kazakovtsev, L. A.; Antamoshkin, A. N.; Masich, I. S.

    2015-10-01

    Authors consider the problem of automatic classification of the electronic, electrical and electromechanical (EEE) components based on results of the test control. Electronic components of the same type used in a high- quality unit must be produced as a single production batch from a single batch of the raw materials. Data of the test control are used for splitting a shipped lot of the components into several classes representing the production batches. Methods such as k-means++ clustering or evolutionary algorithms combine local search and random search heuristics. The proposed fast algorithm returns a unique result for each data set. The result is comparatively precise. If the data processing is performed by the customer of the EEE components, this feature of the algorithm allows easy checking of the results by a producer or supplier.

  11. Compression Strength of Composite Primary Structural Components

    NASA Technical Reports Server (NTRS)

    Johnson, Eric R.; Starnes, James H., Jr. (Technical Monitor)

    2000-01-01

    The focus of research activities under NASA Grant NAG-1-2035 was the response and failure of thin-walled structural components. The research is applicable to the primary load carrying structure of flight vehicles, with particular emphasis on fuselage and wing'structure. Analyses and tests were performed that are applicable to the following structural components an aft pressure bulkhead, or a composite pressure dome, pressure cabin damage containment, and fuselage frames subject to crash-type loads.

  12. Optical components and subsystems: opportunities and challenges

    NASA Astrophysics Data System (ADS)

    Hong, J.; Lee, P.; Zhu, T.; Lee, G.; Xu, K.; Wang, R.

    2006-02-01

    This paper presents a brief review and discussion on the opportunities and challenges facing the optical components and sub-systems vendors. Specifically, this paper discusses some of the current components and sub-system development on the low loss CWDM filters, wavelength blockers, PLC switch arrays, wavelength selective switches, optical protection switching sub-systems, tunable filters and DCMs, and in addition, the fiber-coupled short-wavelength diode-lasers for medical applications.

  13. SA3654 Component characterization. Final report

    SciTech Connect

    Meir, G.W.

    1996-06-01

    AlliedSignal Inc., Federal Manufacturing & Technologies (FM&T), was provided with production capability assurance program (PCAP) funding to develop, characterize, and qualify purchased product components for use on the PRESS-A program. The SA3654, N-Channel, Power MOSFET was identified as a component needing such activity to support PRESS-A. This report presents the characterization activities and results for the SA3654.

  14. Mechanical Components Branch Test Facilities and Capabilities

    NASA Technical Reports Server (NTRS)

    Oswald, Fred B.

    2004-01-01

    The Mechanical Components Branch at NASA Glenn Research Center formulates, conducts, and manages research focused on propulsion systems for both present and advanced aeronautical and space vehicles. The branch is comprised of research teams that perform basic research in three areas: mechanical drives, aerospace seals, and space mechanisms. Each team has unique facilities for testing aerospace hardware and concepts. This report presents an overview of the Mechanical Components Branch test facilities.

  15. Component research for future propulsion systems

    NASA Technical Reports Server (NTRS)

    Walker, C. L.; Weden, G. J.; Zuk, J.

    1981-01-01

    A review of factors related to the acquisition and life-cycle cost, and mission reliability of helicopters is given. The potential for advanced vehicle configurations with improvements in energy efficiency, operating economics, and characteristics to satisfy the demands of the future market are identified. Special attention is given to advanced propulsion systems and related component technologies, and system requirements, powerplants and component thrusts, compressor designs, combustion systems, turbine efficiency, blade tip treatment concepts and shaft dynamics are discussed in detail.

  16. Metamaterials for Miniaturization of Optical Components

    DTIC Science & Technology

    2014-09-24

    AFRL-OSR-VA-TR-2014-0226 METAMATERIALS FOR MINIATURIZATION OF OPTICAL COMPONENTS Aleksandr Figotin UNIVERSITY OF CALIFORNIA IRVINE Final Report 09/24...8-98) v Prescribed by ANSI Std. Z39.18 10/09/2014 Final 30/06/2011-30/06/2014 METAMATERIALS FOR MINIATURIZATION OF OPTICAL COMPONENTS FA9550-11-1...relativistic and spinorial aspects of our neoclassical electromagnetic theory. Metamaterials , fundamentals of electromagnetic theory, dissipation, magnetic

  17. NAC Aftermarket Brake Components Project (Secondary Items)

    DTIC Science & Technology

    2007-02-06

    Supporting the Objective Force – NAC Aftermarket Brake Components Project Version: 06 February 2007 Final UNCLAS: Dist A. Approved for public...release NAC Aftermarket Brake Components Project (Secondary Items) Version: 06 February 2007 Final UNCLAS: Dist A. Approved for public release Leo Miller...Technology Insertion Project Officer (TIPO) US Army National Automotive Center ( NAC ) Warren, MI Report Documentation Page Form ApprovedOMB No. 0704

  18. Electrochemical components employing polysiloxane-derived binders

    DOEpatents

    Delnick, Frank M.

    2013-06-11

    A processed polysiloxane resin binder for use in electrochemical components and the method for fabricating components with the binder. The binder comprises processed polysiloxane resin that is partially oxidized and retains some of its methyl groups following partial oxidation. The binder is suitable for use in electrodes of various types, separators in electrochemical devices, primary lithium batteries, electrolytic capacitors, electrochemical capacitors, fuel cells and sensors.

  19. Method and apparatus for monitoring aircraft components

    DOEpatents

    Dickens, Larry M.; Haynes, Howard D.; Ayers, Curtis W.

    1996-01-01

    Operability of aircraft mechanical components is monitored by analyzing the voltage output of an electrical generator of the aircraft. Alternative generators, for a turbine-driven rotor aircraft, include the gas producer turbine tachometer generator, the power turbine tachometer generator, and the aircraft systems power producing starter/generator. Changes in the peak amplitudes of the fundamental frequency and its harmonics are correlated to changes in condition of the mechanical components.

  20. RDCDS Meteorologoical Component Quick Installation Guide

    SciTech Connect

    Berg, Larry K.; Pekour, Mikhail S.

    2007-11-20

    This guide provides step-by-step instructions for the deployment of one of the Rapidly Deployable Chemical Defense System (RDCDS) weather stations and central control system. Instructions for the deployment and operation of the Atmospheric Systems Corporation miniSODAR™ (SOnic Detection and Ranging) can be found in accompanying manuals developed by Atmospheric Systems Corporation. A detailed description of the system and its components can be found in the manual entitled Description of the RDCDS Meteorological Component.

  1. Method and apparatus for monitoring aircraft components

    DOEpatents

    Dickens, L.M.; Haynes, H.D.; Ayers, C.W.

    1996-01-16

    Operability of aircraft mechanical components is monitored by analyzing the voltage output of an electrical generator of the aircraft. Alternative generators, for a turbine-driven rotor aircraft, include the gas producer turbine tachometer generator, the power turbine tachometer generator, and the aircraft systems power producing starter/generator. Changes in the peak amplitudes of the fundamental frequency and its harmonics are correlated to changes in condition of the mechanical components. 14 figs.

  2. Two-component Abelian sandpile models.

    PubMed

    Alcaraz, F C; Pyatov, P; Rittenberg, V

    2009-04-01

    In one-component Abelian sandpile models, the toppling probabilities are independent quantities. This is not the case in multicomponent models. The condition of associativity of the underlying Abelian algebras imposes nonlinear relations among the toppling probabilities. These relations are derived for the case of two-component quadratic Abelian algebras. We show that Abelian sandpile models with two conservation laws have only trivial avalanches.

  3. Fragrance components of Platanthera bifolia subsp. osca.

    PubMed

    D'Auria, Maurizio; Lorenz, Richard; Racioppi, Rocco; Romano, Vito Antonio

    2017-02-10

    SPME-GC-MS analysis of the scent of Platanthera bifolia subsp. osca collected during the night showed as main components lilac alcohols B, C and D and lilac aldehydes A, B and C. Other significant chemical components were linalool and caryophyllene. Some differences were found in comparison with previously reported analyses of the scent of P. bifolia and Platanthera chlorantha. The most important difference found was in the composition of the ester fraction.

  4. Micro-fabrication Techniques for Target Components

    SciTech Connect

    Miles, R; Hamilton, J; Crawford, J; Ratti, S; Trevino, J; Graff, T; Stockton, C; Harvey, C

    2008-06-10

    Micro-fabrication techniques, derived from the semi-conductor industry, can be used to make a variety of useful mechanical components for targets. A selection of these components including supporting cooling arms for prototype cryogenic inertial confinement fusion targets, stepped and graded density targets for materials dynamics experiments are described. Micro-fabrication enables cost-effective, simultaneous fabrication of multiple high-precision components with complex geometries. Micro-fabrication techniques such as thin-film deposition, photo-lithographic patterning and etch processes normally used in the semi-conductor manufacture industry, can be exploited to make useful mechanical target components. Micro-fabrication processes have in recent years been used to create a number of micro-electro-mechanical systems (MEMS) components such as pressure sensors, accelerometers, ink jet printer heads, microfluidics platforms and the like. These techniques consist primarily of deposition of thin films of material, photo-lithographic patterning and etching processes performed sequentially to produce three dimensional structures using essentially planar processes. While the planar technology can be limiting in terms of the possible geometries of the final product, advantages of using these techniques include the ability to make multiple complex structures simultaneously and cost-effectively. Target components fabricated using these techniques include the supporting cooling arms for cryogenic prototype fusion ignition targets, stepped targets for equation-of-state experiments, and graded density reservoirs for material strength experiments.

  5. PROJECTED PRINCIPAL COMPONENT ANALYSIS IN FACTOR MODELS

    PubMed Central

    Fan, Jianqing; Liao, Yuan; Wang, Weichen

    2016-01-01

    This paper introduces a Projected Principal Component Analysis (Projected-PCA), which employees principal component analysis to the projected (smoothed) data matrix onto a given linear space spanned by covariates. When it applies to high-dimensional factor analysis, the projection removes noise components. We show that the unobserved latent factors can be more accurately estimated than the conventional PCA if the projection is genuine, or more precisely, when the factor loading matrices are related to the projected linear space. When the dimensionality is large, the factors can be estimated accurately even when the sample size is finite. We propose a flexible semi-parametric factor model, which decomposes the factor loading matrix into the component that can be explained by subject-specific covariates and the orthogonal residual component. The covariates’ effects on the factor loadings are further modeled by the additive model via sieve approximations. By using the newly proposed Projected-PCA, the rates of convergence of the smooth factor loading matrices are obtained, which are much faster than those of the conventional factor analysis. The convergence is achieved even when the sample size is finite and is particularly appealing in the high-dimension-low-sample-size situation. This leads us to developing nonparametric tests on whether observed covariates have explaining powers on the loadings and whether they fully explain the loadings. The proposed method is illustrated by both simulated data and the returns of the components of the S&P 500 index. PMID:26783374

  6. Components of Comprehensive and Effective Transitional Care.

    PubMed

    Naylor, Mary D; Shaid, Elizabeth C; Carpenter, Deborah; Gass, Brianna; Levine, Carol; Li, Jing; Malley, Ann; McCauley, Kathleen; Nguyen, Huong Q; Watson, Heather; Brock, Jane; Mittman, Brian; Jack, Brian; Mitchell, Suzanne; Callicoatte, Becky; Schall, John; Williams, Mark V

    2017-04-03

    Transitional care (TC) has received widespread attention from researchers, health system leaders, clinicians, and policy makers as they attempt to improve health outcomes and reduce preventable hospital readmissions, yet little is known about the critical elements of effective TC and how they relate to patients' and caregivers' needs and experiences. To address this gap, the Patient-Centered Outcomes Research Institute (PCORI) funded a national study, Achieving patient-centered Care and optimized Health In care transitions by Evaluating the Value of Evidence (Project ACHIEVE). A primary aim of the study is the identification of TC components that yield desired patient and caregiver outcomes. Project ACHIEVE established a multistakeholder workgroup to recommend essential TC components for vulnerable Medicare beneficiaries. Guided by a review of published evidence, the workgroup identified and defined a preliminary set of components and then analyzed how well the set aligned with real-world patients' and caregivers' experiences. Through this process, the workgroup identified eight TC components: patient engagement, caregiver engagement, complexity and medication management, patient education, caregiver education, patients' and caregivers' well-being, care continuity, and accountability. Although the degree of attention given to each component will vary based on the specific needs of patients and caregivers, workgroup members agree that health systems need to address all components to ensure optimal TC for all Medicare beneficiaries.

  7. Multiple-component covalent organic frameworks

    PubMed Central

    Huang, Ning; Zhai, Lipeng; Coupry, Damien E.; Addicoat, Matthew A.; Okushita, Keiko; Nishimura, Katsuyuki; Heine, Thomas; Jiang, Donglin

    2016-01-01

    Covalent organic frameworks are a class of crystalline porous polymers that integrate molecular building blocks into periodic structures and are usually synthesized using two-component [1+1] condensation systems comprised of one knot and one linker. Here we report a general strategy based on multiple-component [1+2] and [1+3] condensation systems that enable the use of one knot and two or three linker units for the synthesis of hexagonal and tetragonal multiple-component covalent organic frameworks. Unlike two-component systems, multiple-component covalent organic frameworks feature asymmetric tiling of organic units into anisotropic skeletons and unusually shaped pores. This strategy not only expands the structural complexity of skeletons and pores but also greatly enhances their structural diversity. This synthetic platform is also widely applicable to multiple-component electron donor–acceptor systems, which lead to electronic properties that are not simply linear summations of those of the conventional [1+1] counterparts. PMID:27460607

  8. Component Repair Times Obtained from MSPI Data

    SciTech Connect

    Eide, Steven A.

    2015-05-01

    Information concerning times to repair or restore equipment to service given a failure is valuable to probabilistic risk assessments (PRAs). Examples of such uses in modern PRAs include estimation of the probability of failing to restore a failed component within a specified time period (typically tied to recovering a mitigating system before core damage occurs at nuclear power plants) and the determination of mission times for support system initiating event (SSIE) fault tree models. Information on equipment repair or restoration times applicable to PRA modeling is limited and dated for U.S. commercial nuclear power plants. However, the Mitigating Systems Performance Index (MSPI) program covering all U.S. commercial nuclear power plants provides up-to-date information on restoration times for a limited set of component types. This paper describes the MSPI program data available and analyzes the data to obtain median and mean component restoration times as well as non-restoration cumulative probability curves. The MSPI program provides guidance for monitoring both planned and unplanned outages of trains of selected mitigating systems deemed important to safety. For systems included within the MSPI program, plants monitor both train UA and component unreliability (UR) against baseline values. If the combined system UA and UR increases sufficiently above established baseline results (converted to an estimated change in core damage frequency or CDF), a “white” (or worse) indicator is generated for that system. That in turn results in increased oversight by the US Nuclear Regulatory Commission (NRC) and can impact a plant’s insurance rating. Therefore, there is pressure to return MSPI program components to service as soon as possible after a failure occurs. Three sets of unplanned outages might be used to determine the component repair durations desired in this article: all unplanned outages for the train type that includes the component of interest, only

  9. Performance Engineering Technology for Scientific Component Software

    SciTech Connect

    Malony, Allen D.

    2007-05-08

    Large-scale, complex scientific applications are beginning to benefit from the use of component software design methodology and technology for software development. Integral to the success of component-based applications is the ability to achieve high-performing code solutions through the use of performance engineering tools for both intra-component and inter-component analysis and optimization. Our work on this project aimed to develop performance engineering technology for scientific component software in association with the DOE CCTTSS SciDAC project (active during the contract period) and the broader Common Component Architecture (CCA) community. Our specific implementation objectives were to extend the TAU performance system and Program Database Toolkit (PDT) to support performance instrumentation, measurement, and analysis of CCA components and frameworks, and to develop performance measurement and monitoring infrastructure that could be integrated in CCA applications. These objectives have been met in the completion of all project milestones and in the transfer of the technology into the continuing CCA activities as part of the DOE TASCS SciDAC2 effort. In addition to these achievements, over the past three years, we have been an active member of the CCA Forum, attending all meetings and serving in several working groups, such as the CCA Toolkit working group, the CQoS working group, and the Tutorial working group. We have contributed significantly to CCA tutorials since SC'04, hosted two CCA meetings, participated in the annual ACTS workshops, and were co-authors on the recent CCA journal paper [24]. There are four main areas where our project has delivered results: component performance instrumentation and measurement, component performance modeling and optimization, performance database and data mining, and online performance monitoring. This final report outlines the achievements in these areas for the entire project period. The submitted progress

  10. Supersymmetric component actions via coset approach

    NASA Astrophysics Data System (ADS)

    Bellucci, S.; Krivonos, S.; Sutulin, A.

    2013-10-01

    We propose a method to construct the on-shell component actions for the theories with 1/2 partial breaking of global supersymmetry within the nonlinear realization (coset) approach. In contrast with the standard superfield approach in which unbroken supersymmetry plays the leading role, we have shifted the attention to the spontaneously broken supersymmetry. It turns out that in the theories in which half of supersymmetries is spontaneously broken, all physical fermions are just the fermions of the nonlinear realization. Moreover, the transformation properties of these fermions with respect to the broken supersymmetry are the same as in the famous Volkov-Akulov model. Just this fact completely fixed all possible appearances of the fermions in the component action: they can enter the action through the determinant of the vielbein (to compensate the transformation of the volume form) and the covariant derivatives, only. It is very important that in our parametrization of the coset the rest of physical components, i.e. all bosonic components, transform as “matter fields” with respect to the broken supersymmetry. Clearly, in such a situation the component action acquires the form of the Volkov-Akulov action for these “matter fields”. The complete form of the action can be further fixed by two additional requirements: (a) to reproduce the bosonic limit, which is explicitly known in many interesting cases, and (b) to have a proper linearized form, which has to be invariant with respect to the linearized unbroken supersymmetry. We supply the general consideration by a detailed example of the component action of N=1 supermembrane in D=4 constructed within our procedure. In this case we provide the exact proof of the invariance of the constructed component action with respect to both, broken and unbroken supersymmetries.

  11. Component evolution in general random intersection graphs

    SciTech Connect

    Bradonjic, Milan; Hagberg, Aric; Hengartner, Nick; Percus, Allon G

    2010-01-01

    We analyze component evolution in general random intersection graphs (RIGs) and give conditions on existence and uniqueness of the giant component. Our techniques generalize the existing methods for analysis on component evolution in RIGs. That is, we analyze survival and extinction properties of a dependent, inhomogeneous Galton-Watson branching process on general RIGs. Our analysis relies on bounding the branching processes and inherits the fundamental concepts from the study on component evolution in Erdos-Renyi graphs. The main challenge becomes from the underlying structure of RIGs, when the number of offsprings follows a binomial distribution with a different number of nodes and different rate at each step during the evolution. RIGs can be interpreted as a model for large randomly formed non-metric data sets. Besides the mathematical analysis on component evolution, which we provide in this work, we perceive RIGs as an important random structure which has already found applications in social networks, epidemic networks, blog readership, or wireless sensor networks.

  12. Overview of blood components and their preparation

    PubMed Central

    Basu, Debdatta; Kulkarni, Rajendra

    2014-01-01

    The whole blood which is a mixture of cells, colloids and crystalloids can be separated into different blood components namely packed red blood cell (PRBC) concentrate, platelet concentrate, fresh frozen plasma and cryoprecipitate. Each blood component is used for a different indication; thus the component separation has maximized the utility of one whole blood unit. Different components need different storage conditions and temperature requirements for therapeutic efficacy. A variety of equipments to maintain suitable ambient conditions during storage and transportation are in vogue. The blood components being foreign to a patient may produce adverse effects that may range from mild allergic manifestations to fatal reactions. Such reactions are usually caused by plasma proteins, leucocytes, red cell antigens, plasma and other pathogens. To avoid and reduce such complications, blood products are modified as leukoreduced products, irradiated products, volume reduced products, saline washed products and pathogen inactivated products. The maintenance of blood inventory forms a major concern of blood banking particularly of rare blood groups routinely and common blood groups during disasters. PRBCs can be stored for years using cryopreservation techniques. New researches in red cell cultures and blood substitutes herald new era in blood banking. PMID:25535413

  13. Flight service evaluation of composite helicopter components

    NASA Technical Reports Server (NTRS)

    Mardoian, George H.; Ezzo, Maureen B.

    1990-01-01

    An assessment is presented of ten composite tail rotor spars and four horizontal stabilizers exposed to the effects of in-flight commercial service for up to nine years to establish realistic environmental factors for use in future designs. This evaluation is supported by test results of helicopter components and panels which have been exposed to outdoor environmental effects since 1979. Full scale static and fatigue tests were conducted on graphite/epoxy and Kevlar/epoxy composite components removed from Sikorsky Model S-76 helicopters in commercial operations off the Gulf Coast of Louisiana. Small scale static and fatigue tests were conducted on coupons obtained from panels exposed to outdoor conditions in Stratford, CT and West Palm Beach, Florida. The panel materials and ply configurations were representative of the S-76 components. The results are discussed of moisture analyses and strength tests on both the S-76 components and composite panels after up to nine years of outdoor exposure. Full scale tests performed on the helicopter components did not disclose any significant reductions from the baseline strengths. The results increased confidence in the long term durability of advanced composite materials in helicopter structural applications.

  14. Overview of blood components and their preparation.

    PubMed

    Basu, Debdatta; Kulkarni, Rajendra

    2014-09-01

    The whole blood which is a mixture of cells, colloids and crystalloids can be separated into different blood components namely packed red blood cell (PRBC) concentrate, platelet concentrate, fresh frozen plasma and cryoprecipitate. Each blood component is used for a different indication; thus the component separation has maximized the utility of one whole blood unit. Different components need different storage conditions and temperature requirements for therapeutic efficacy. A variety of equipments to maintain suitable ambient conditions during storage and transportation are in vogue. The blood components being foreign to a patient may produce adverse effects that may range from mild allergic manifestations to fatal reactions. Such reactions are usually caused by plasma proteins, leucocytes, red cell antigens, plasma and other pathogens. To avoid and reduce such complications, blood products are modified as leukoreduced products, irradiated products, volume reduced products, saline washed products and pathogen inactivated products. The maintenance of blood inventory forms a major concern of blood banking particularly of rare blood groups routinely and common blood groups during disasters. PRBCs can be stored for years using cryopreservation techniques. New researches in red cell cultures and blood substitutes herald new era in blood banking.

  15. Domain Adaptation with Conditional Transferable Components

    PubMed Central

    Gong, Mingming; Zhang, Kun; Liu, Tongliang; Tao, Dacheng; Glymour, Clark; Schölkopf, Bernhard

    2017-01-01

    Domain adaptation arises in supervised learning when the training (source domain) and test (target domain) data have different distributions. Let X and Y denote the features and target, respectively, previous work on domain adaptation mainly considers the covariate shift situation where the distribution of the features P(X) changes across domains while the conditional distribution P(Y∣X) stays the same. To reduce domain discrepancy, recent methods try to find invariant components T(X) that have similar P(T(X)) on different domains by explicitly minimizing a distribution discrepancy measure. However, it is not clear if P(Y∣T(X)) in different domains is also similar when P(Y∣X) changes. Furthermore, transferable components do not necessarily have to be invariant. If the change in some components is identifiable, we can make use of such components for prediction in the target domain. In this paper, we focus on the case where P(X∣Y) and P(Y) both change in a causal system in which Y is the cause for X. Under appropriate assumptions, we aim to extract conditional transferable components whose conditional distribution P(T(X)∣Y) is invariant after proper location-scale (LS) transformations, and identify how P(Y) changes between domains simultaneously. We provide theoretical analysis and empirical evaluation on both synthetic and real-world data to show the effectiveness of our method. PMID:28239433

  16. Domain Adaptation with Conditional Transferable Components.

    PubMed

    Gong, Mingming; Zhang, Kun; Liu, Tongliang; Tao, Dacheng; Glymour, Clark; Schölkopf, Bernhard

    2016-06-01

    Domain adaptation arises in supervised learning when the training (source domain) and test (target domain) data have different distributions. Let X and Y denote the features and target, respectively, previous work on domain adaptation mainly considers the covariate shift situation where the distribution of the features P(X) changes across domains while the conditional distribution P(Y∣X) stays the same. To reduce domain discrepancy, recent methods try to find invariant components [Formula: see text] that have similar [Formula: see text] on different domains by explicitly minimizing a distribution discrepancy measure. However, it is not clear if [Formula: see text] in different domains is also similar when P(Y∣X) changes. Furthermore, transferable components do not necessarily have to be invariant. If the change in some components is identifiable, we can make use of such components for prediction in the target domain. In this paper, we focus on the case where P(X∣Y) and P(Y) both change in a causal system in which Y is the cause for X. Under appropriate assumptions, we aim to extract conditional transferable components whose conditional distribution [Formula: see text] is invariant after proper location-scale (LS) transformations, and identify how P(Y) changes between domains simultaneously. We provide theoretical analysis and empirical evaluation on both synthetic and real-world data to show the effectiveness of our method.

  17. Flight service evaluation of composite helicopter components

    NASA Technical Reports Server (NTRS)

    Mardoian, George H.; Ezzo, Maureen B.

    1994-01-01

    This paper presents the results of a NASA funded contract and Sikorsky research and development programs to evaluate structural composite components in flight service on Sikorsky Model S-76 helicopters. Selected components were removed and tested at prescribed intervals over a nine year time frame. Four horizontal stabilizers and thirteen tail rotor spars were returned from commercial service in West Palm Beach, Florida and in the Gulf Coast region of Louisiana to determine the long term effects of operations in hot and humid climates on component performance. Concurrent with the flight component evaluation, panels of materials used in their fabrication were exposed to the environment in ground racks. Selected panels were tested annually to determine the effects of exposure on physical and mechanical properties. The results of 55,741 component flight hours and 911 months of field exposure are reported and compared with initial Federal Aviation Administration (FAA) certification data. The findings of this program have provided increased confidence in the long term durability of advanced composite materials used in helicopter structural applications.

  18. Spectral Components Analysis of Diffuse Emission Processes

    SciTech Connect

    Malyshev, Dmitry; /KIPAC, Menlo Park

    2012-09-14

    We develop a novel method to separate the components of a diffuse emission process based on an association with the energy spectra. Most of the existing methods use some information about the spatial distribution of components, e.g., closeness to an external template, independence of components etc., in order to separate them. In this paper we propose a method where one puts conditions on the spectra only. The advantages of our method are: 1) it is internal: the maps of the components are constructed as combinations of data in different energy bins, 2) the components may be correlated among each other, 3) the method is semi-blind: in many cases, it is sufficient to assume a functional form of the spectra and determine the parameters from a maximization of a likelihood function. As an example, we derive the CMB map and the foreground maps for seven yeas of WMAP data. In an Appendix, we present a generalization of the method, where one can also add a number of external templates.

  19. PACS component testing: beta and acceptance testing

    NASA Astrophysics Data System (ADS)

    Honeyman-Buck, Janice C.; Frost, Meryll M.; Staab, Edward V.

    1997-05-01

    The functionality and performance expectations of all PACS components must be specified at the time of purchase and tested completely upon delivery to assure customer satisfaction and successful adoption of the new technology. This process may be more elaborate if the customer agrees to serve as a Beta test site for a new component or a new revision of an existing component.A carefully designed test plan will save time at installation, will allow the customer and vendor to agree on expectations, and will assure that the installation will proceed as planned. This paper describes the test procedure used at the University of Florida to accept each PACS component, either a commercial product, or one developed in house. A set of documents contain descriptions of the pre-installation environment, sets of studies to be used in the test, installation checklist, functional usage reports, subjective evaluations, and problem reporting forms. Training and user documentation is also reviewed and 'help lists' are created to help users perform the most common functions. Although details in the documents are changed to match the type of component being tested, the general form of the test remains the same. A formal procedure for testing the functionality and performance of new equipment can save time for both the vendor and the customer and, if specified at the time of purchase, can serve to document the expectations of the customer. Following these procedures will assure a successful installation and improve customer satisfaction.

  20. Progress in photovoltaic system and component improvements

    SciTech Connect

    Thomas, H.P.; Kroposki, B.; McNutt, P.; Witt, C.E.; Bower, W.; Bonn, R.; Hund, T.D.

    1998-07-01

    The Photovoltaic Manufacturing Technology (PVMaT) project is a partnership between the US government (through the US Department of Energy [DOE]) and the PV industry. Part of its purpose is to conduct manufacturing technology research and development to address the issues and opportunities identified by industry to advance photovoltaic (PV) systems and components. The project was initiated in 1990 and has been conducted in several phases to support the evolution of PV industrial manufacturing technology. Early phases of the project stressed PV module manufacturing. Starting with Phase 4A and continuing in Phase 5A, the goals were broadened to include improvement of component efficiency, energy storage and manufacturing and system or component integration to bring together all elements for a PV product. This paper summarizes PV manufacturers` accomplishments in components, system integration, and alternative manufacturing methods. Their approaches have resulted in improved hardware and PV system performance, better system compatibility, and new system capabilities. Results include new products such as Underwriters Laboratories (UL)-listed AC PV modules, modular inverters, and advanced inverter designs that use readily available and standard components. Work planned in Phase 5A1 includes integrated residential and commercial roof-top systems, PV systems with energy storage, and 300-Wac to 4-kWac inverters.

  1. Component technology for Stirling power converters

    SciTech Connect

    Thieme, L.G.

    1994-09-01

    NASA Lewis Research Center has organized a component technology program as part of the efforts to develop Stirling converter technology for space power applications. The Stirling space power program is part of the NASA High Capacity Power Project of the Civil Space Technology Initiative (CSTI). NASA Lewis is also providing technical management for a DOE/Sandia program to develop Stirling converters for solar terrestrial power producing electricity for the utility grid. The primary contractors for the space power and solar terrestrial programs develop component technologies directly related to their program goals. This Lewis component technology effort, while coordinated with the main programs, aims at longer term issues, advanced technologies, and independent assessments. This paper will present an overview of work on linear alternators, engine/alternator/load interactions and controls, heat exchangers, materials, life and reliability, and bearings.

  2. Laser Micromachining Fabrication of THz Components

    NASA Technical Reports Server (NTRS)

    DrouetdAubigny, C.; Walker, C.; Jones, B.; Groppi, C.; Papapolymerou, J.; Tavenier, C.

    2001-01-01

    Laser micromachining techniques can be used to fabricate high-quality waveguide structures and quasi-optical components to micrometer accuracies. Successful GHz designs can be directly scaled to THz frequencies. We expect this promising technology to allow the construction of the first fully integrated THz heterodyne imaging arrays. At the University of Arizona, construction of the first laser micromachining system designed for THz waveguide components fabrication has been completed. Once tested and characterized our system will be used to construct prototype THz lx4 focal plane mixer arrays, magic tees, AR coated silicon lenses, local oscillator source phase gratings, filters and more. Our system can micro-machine structures down to a few microns accuracy and up to 6 inches across in a short time. This paper discusses the design and performance of our micromachining system, and illustrates the type, range and performance of components this exciting new technology will make accessible to the THz community.

  3. Component technology for stirling power converters

    NASA Technical Reports Server (NTRS)

    Thieme, Lanny G.

    1991-01-01

    NASA Lewis Research Center has organized a component technology program as part of the efforts to develop Stirling converter technology for space power applications. The Stirling Space Power Program is part of the NASA High Capacity Power Project of the Civil Space Technology Initiative (CSTI). NASA Lewis is also providing technical management for the DOE/Sandia program to develop Stirling converters for solar terrestrial power producing electricity for the utility grid. The primary contractors for the space power and solar terrestrial programs develop component technologies directly related to their goals. This Lewis component technology effort, while coordinated with the main programs, aims at longer term issues, advanced technologies, and independent assessments. An overview of work on linear alternators, engine/alternator/load interactions and controls, heat exchangers, materials, life and reliability, and bearings is presented.

  4. Loaded transducer for downhole drilling components

    DOEpatents

    Hall, David R.; Fox, Joe; Daly, Jeffery E.

    2009-05-05

    A system for transmitting information between downhole components has a first downhole component with a first mating surface and a second downhole component having a second mating surface configured to substantially mate with the first mating surface. The system also has a first transmission element with a first communicating surface and is mounted within a recess in the first mating surface. The first transmission element also has an angled surface. The recess has a side with multiple slopes for interacting with the angled surface, each slope exerting a different spring force on the first transmission element. A second transmission element has a second communicating surface mounted proximate the second mating surface and adapted to communicate with the first communicating surface.

  5. Flight service evaluation of composite helicopter components

    NASA Technical Reports Server (NTRS)

    Rich, M. J.; Lowry, D. W.

    1982-01-01

    This first interim report presents the technical background for including environmental effects in the design of helicopter composite structures, and test results after approximately two year field exposure of components and panels. Composite structural components were removed from Sikorsky S-76 helicopters commercially operated in the Gulf Coast region of Louisiana. Fatigue tests were conducted for a graphite/epoxy tail rotor spar and static test for a graphite/epoxy and Kevlar/epoxy stabilizer. Graphite/epoxy and Kevlar/epoxy panels are being exposed to the outdoor environment in Stratford, Connecticut and West Palm Beach, Florida. For this reporting period the two year panels were returned, moisture measurements taken, and strength tests conducted. Results are compared with initial type certificate strengths for components and with initial laboratory coupon tests for the exposed panels. Comparisons are also presented with predicted and measured moisture contents.

  6. Evaluation of beryllium for space shuttle components

    NASA Technical Reports Server (NTRS)

    Trapp, A. E.

    1972-01-01

    Application of beryllium to specific full-scale space shuttle structural components and assemblies was studied. Material evaluations were conducted to check the mechanical properties of as-received material to gain design information on characteristics needed for the material in the space shuttle environment, and to obtain data needed for evaluating component and panel tests. Four beryllium structural assemblies were analyzed and designed. Selected components of these assemblies, representing areas of critical loading or design/process uncertainty, were designed and tested, and two panel assemblies were fabricated. Trends in cost and weight factors were determined by progressive estimation at key points of preliminary design, final design, and fabrication to aid in a cost/weight evaluation of the use of beryllium.

  7. Protection of lithographic components from particle contamination

    DOEpatents

    Klebanoff, Leonard E.; Rader, Daniel J.

    2000-01-01

    A system that employs thermophoresis to protect lithographic surfaces from particle deposition and operates in an environment where the pressure is substantially constant and can be sub-atmospheric. The system (thermophoretic pellicle) comprises an enclosure that surrounds a lithographic component whose surface is being protected from particle deposition. The enclosure is provided with means for introducing a flow of gas into the chamber and at least one aperture that provides for access to the lithographic surface for the entry and exit of a beam of radiation, for example, and further controls gas flow into a surrounding low pressure environment such that a higher pressure is maintained within the enclosure and over the surface being protected. The lithographic component can be heated or, alternatively the walls of the enclosure can be cooled to establish a temperature gradient between the surface of the lithographic component and the walls of the enclosure, thereby enabling the thermophoretic force that resists particle deposition.

  8. PCA: Principal Component Analysis for spectra modeling

    NASA Astrophysics Data System (ADS)

    Hurley, Peter D.; Oliver, Seb; Farrah, Duncan; Wang, Lingyu; Efstathiou, Andreas

    2012-07-01

    The mid-infrared spectra of ultraluminous infrared galaxies (ULIRGs) contain a variety of spectral features that can be used as diagnostics to characterize the spectra. However, such diagnostics are biased by our prior prejudices on the origin of the features. Moreover, by using only part of the spectrum they do not utilize the full information content of the spectra. Blind statistical techniques such as principal component analysis (PCA) consider the whole spectrum, find correlated features and separate them out into distinct components. This code, written in IDL, classifies principal components of IRS spectra to define a new classification scheme using 5D Gaussian mixtures modelling. The five PCs and average spectra for the four classifications to classify objects are made available with the code.

  9. Prognostics for Electronics Components of Avionics Systems

    NASA Technical Reports Server (NTRS)

    Celaya, Jose R.; Saha, Bhaskar; Wysocki, Philip F.; Goebel, Kai F.

    2009-01-01

    Electronics components have and increasingly critical role in avionics systems and for the development of future aircraft systems. Prognostics of such components is becoming a very important research filed as a result of the need to provide aircraft systems with system level health management. This paper reports on a prognostics application for electronics components of avionics systems, in particular, its application to the Isolated Gate Bipolar Transistor (IGBT). The remaining useful life prediction for the IGBT is based on the particle filter framework, leveraging data from an accelerated aging tests on IGBTs. The accelerated aging test provided thermal-electrical overstress by applying thermal cycling to the device. In-situ state monitoring, including measurements of the steady-state voltages and currents, electrical transients, and thermal transients are recorded and used as potential precursors of failure.

  10. Comparison of Tritium Component Failure Rate Data

    SciTech Connect

    Lee C. Cadwallader

    2004-09-01

    Published failure rate values from the US Tritium Systems Test Assembly, the Japanese Tritium Process Laboratory, the German Tritium Laboratory Karlsruhe, and the Joint European Torus Active Gas Handling System have been compared. This comparison is on a limited set of components, but there is a good variety of data sets in the comparison. The data compared reasonably well. The most reasonable failure rate values are recommended for use on next generation tritium handling system components, such as those in the tritium plant systems for the International Thermonuclear Experimental Reactor and the tritium fuel systems of inertial fusion facilities, such as the US National Ignition Facility. These data and the comparison results are also shared with the International Energy Agency cooperative task on fusion component failure rate data.

  11. Implementation of nurse authorisation of blood components.

    PubMed

    Pirie, Elizabeth S; Sinclair, Charles

    A collaborative project between the Better Blood Transfusion teams in the Scottish National Blood Transfusion Service (SNBTS) and NHS Blood and Transplant (NHSBT) explored the feasibility of nurses prescribing blood components, and clarified that blood components are not considered medicinal products, so the term prescription does not apply. No legal barriers to trained, competent nurses and midwives undertaking this role were identified and nurse authorisation of blood components was seen as having the potential to improve patients' experiences. A number of NHS Scotland boards showed interest in implementing this but there are challenges to ensuring that a robust governance structure is in place to support role development . Progress has been made with support from the Scottish Government Health Department and using a governance framework that was developed to support nurses who wish to undertake this role.

  12. Coating for components requiring hydrogen peroxide compatibility

    NASA Technical Reports Server (NTRS)

    Yousefiani, Ali (Inventor)

    2010-01-01

    The present invention provides a heretofore-unknown use for zirconium nitride as a hydrogen peroxide compatible protective coating that was discovered to be useful to protect components that catalyze the decomposition of hydrogen peroxide or corrode when exposed to hydrogen peroxide. A zirconium nitride coating of the invention may be applied to a variety of substrates (e.g., metals) using art-recognized techniques, such as plasma vapor deposition. The present invention further provides components and articles of manufacture having hydrogen peroxide compatibility, particularly components for use in aerospace and industrial manufacturing applications. The zirconium nitride barrier coating of the invention provides protection from corrosion by reaction with hydrogen peroxide, as well as prevention of hydrogen peroxide decomposition.

  13. Seafood Consumption and Components for Health

    PubMed Central

    Hosomi, Ryota; Yoshida, Munehiro; Fukunaga, Kenji

    2012-01-01

    In recent years, in developed countries and around the world, lifestyle-related diseases have become a serious problem. Numerous epidemiological studies and clinical trials have demonstrated that diet is one of the major factors that influence susceptibility to lifestyle-related diseases, especially the middle-senile state. Studies examining dietary habits have revealed the health benefits of seafood consumption. Seafood contains functional components that are not present in terrestrial organisms. These components include n-3-polyunsaturated fatty acids, such as eicosapentaenoic acid and docosahexsaenoic acid, which aid in the prevention of arteriosclerotic and thrombotic disease. In addition, seafood is a superior source of various nutrients, such as protein, amino acids, fiber, vitamins, and minerals. This review focuses on the components derived from seafood and examines the significant role they play in the maintenance and promotion of health. PMID:22980234

  14. Nonintrusive temperature measurements on advanced turbomachinery components

    SciTech Connect

    Noel, B.W.; Turley, W.D.; Lewis, W.

    1992-12-31

    A nonintrusive, noncontacting method we developed for temperature measurements in hostile environments is well-suited for measurements on advanced turbine components. The method is not only superior to thermocouples in sufficiently difficult environments, but also is the only known method for making measurements in situations where no form of pyrometry works. We demonstrated the method, which uses laser-induced fluorescence of thermographic phosphors bonded to the component surfaces, on turbine blades and vanes in developmental turbine engines. The method is extendable to the much-higher temperatures expected inside advanced turbomachinery. Of particular note is the adaptability of the method to surface-temperature measurements on ceramics operating at high temperatures. In this temperature range, the ceramics become translucent, and surface emissivity becomes meaningless. We shall discuss the method, its advantages and limitations, recent test results on operating turbine engines, and the extension to ceramic components.

  15. Component technology for Stirling power converters

    NASA Technical Reports Server (NTRS)

    Thieme, Lanny G.

    1991-01-01

    NASA Lewis Research Center has organized a component technology program as part of the efforts to develop Stirling converter technology for space power applications. The Stirling Space Power Program is part of the NASA High Capacity Power Project of the Civil Space Technology Initiative (CSTI). NASA Lewis is also providing technical management for the DOE/Sandia program to develop Stirling converters for solar terrestrial power producing electricity for the utility grid. The primary contractors for the space power and solar terrestrial programs develop component technologies directly related to their goals. This Lewis component technology effort, while coordinated with the main programs, aims at longer term issues, advanced technologies, and independent assessments. An overview of work on linear alternators, engine/alternator/load interactions and controls, heat exchangers, materials, life and reliability, and bearings is presented.

  16. Optimization of acetabular component orientation using DOE

    NASA Astrophysics Data System (ADS)

    Krepelka, Mircea; Toth-Taşcǎu, Mirela

    2012-09-01

    Stress shielding is increasingly recognized as an important cause of acetabular component failure. Several studies have been focused on improving the acetabular component placement to reduce the risk of dislocation, impingement and range of motion but little is known of its influence on implant-bone interface pressures. This study employs experimental design, 3D reconstruction and FE simulation to identify the most significant factors for acetabular component behavior and predict the best configuration of acetabular spatial orientation angles within the constraints of the Lewinnek's safe zone in order to minimize peak contact pressures. Data analysis by response surface method revealed that the magnitude of periacetabular pressures was significantly reduced by the anteversion angle at its lowest value as well as the abduction angle located at the central point value, which corresponded to a 40° abduction and 5° anteversion of cup orientation.

  17. Radiation heating in selected NERVA engine components

    NASA Technical Reports Server (NTRS)

    Courtney, J. C.; Hertelendy, N. A.; Lindsey, B. A.

    1972-01-01

    The role of heating from nuclear radiation in design of the NERVA engine is treated. Some components are subjected to very high gamma heating rates in excess of 0.5 Btu/cubic inch/sec in steel in the primary nozzle or 0.25 Btu/cubic inch/sec in aluminum in the pressure vessel. These components must be cooled by a fraction of the liquid hydrogen propellant before it is passed through the core, heated, and expanded out the nozzle as a gas. Other components that are subjected to lower heating rates such as the thrust structure and the disk shield are designed so that they would not require liquid hydrogen cooling. Typical gamma and neutron heating rates, resulting temperatures, and their design consequences are discussed. Calculational techniques used in the nuclear and thermal analyses of the NERVA engine are briefly treated.

  18. Intrinsic superstatistical components of financial time series

    NASA Astrophysics Data System (ADS)

    Vamoş, Călin; Crăciun, Maria

    2014-12-01

    Time series generated by a complex hierarchical system exhibit various types of dynamics at different time scales. A financial time series is an example of such a multiscale structure with time scales ranging from minutes to several years. In this paper we decompose the volatility of financial indices into five intrinsic components and we show that it has a heterogeneous scale structure. The small-scale components have a stochastic nature and they are independent 99% of the time, becoming synchronized during financial crashes and enhancing the heavy tails of the volatility distribution. The deterministic behavior of the large-scale components is related to the nonstationarity of the financial markets evolution. Our decomposition of the financial volatility is a superstatistical model more complex than those usually limited to a superposition of two independent statistics at well-separated time scales.

  19. Irradiation properties of T0 chopper components

    NASA Astrophysics Data System (ADS)

    Itoh, Shinichi; Ueno, Kenji; Ohkubo, Ryuji; Sagehashi, Hidenori; Funahashi, Yoshisato; Yokoo, Tetsuya

    2011-10-01

    We investigated the irradiation properties of the components of a T0 chopper. The organic materials in the rotor bearing grease, the magnetic fluids in seals, and the rubber in the timing belt, as well as the semiconductor materials in the rotation sensor and motor encoder, were all irradiated with high-energy γ-rays up to 100 kGy. No significant damage that shortens the lifetime of a T0 chopper was observed for the mechanical components. However, the semiconductor components were damaged by the irradiation. For the rotation sensor system detecting the rotor phase, the signal from a marker on the rotor shaft was transmitted outside the shielding by an optical fiber with radiation-proofing and the electrical circuits were removed from the beamline shielding. The lifetime of the motor encoder possibly meets the requirement for the maintenance period of the T0 chopper.

  20. Component evaluation testing and analysis algorithms.

    SciTech Connect

    Hart, Darren M.; Merchant, Bion John

    2011-10-01

    The Ground-Based Monitoring R&E Component Evaluation project performs testing on the hardware components that make up Seismic and Infrasound monitoring systems. The majority of the testing is focused on the Digital Waveform Recorder (DWR), Seismic Sensor, and Infrasound Sensor. In order to guarantee consistency, traceability, and visibility into the results of the testing process, it is necessary to document the test and analysis procedures that are in place. Other reports document the testing procedures that are in place (Kromer, 2007). This document serves to provide a comprehensive overview of the analysis and the algorithms that are applied to the Component Evaluation testing. A brief summary of each test is included to provide the context for the analysis that is to be performed.

  1. Independent component analysis in spiking neurons.

    PubMed

    Savin, Cristina; Joshi, Prashant; Triesch, Jochen

    2010-04-22

    Although models based on independent component analysis (ICA) have been successful in explaining various properties of sensory coding in the cortex, it remains unclear how networks of spiking neurons using realistic plasticity rules can realize such computation. Here, we propose a biologically plausible mechanism for ICA-like learning with spiking neurons. Our model combines spike-timing dependent plasticity and synaptic scaling with an intrinsic plasticity rule that regulates neuronal excitability to maximize information transmission. We show that a stochastically spiking neuron learns one independent component for inputs encoded either as rates or using spike-spike correlations. Furthermore, different independent components can be recovered, when the activity of different neurons is decorrelated by adaptive lateral inhibition.

  2. Advanced laser microfabrication of photonic components

    NASA Astrophysics Data System (ADS)

    Herman, Peter R.; Chen, Kevin P.; Corkum, Paul B.; Naumov, Andrei; Ng, Sandy; Zhang, Jie

    2000-11-01

    The powerful transition from electronic to photonic systems in today's Internet-driven communication industry is driving the development of processes to miniaturize and integrate optical components. New processing and packaging technologies are now required that can precisely shape and assemble transparent optical components to sub-wavelength accuracy. Laser microfabrication technology is beginning to play a role here. Our groups are exploring two extremes in laser technology- ultrafast lasers and very short wavelength F2 lasers- to microstructure optical surfaces and to profile refractive-index structures inside transparent glasses. In this paper, we compare photosensitivity responses, spatial resolution, and processing windows for the deep-ultraviolet and ultrafast laser approaches, and discuss prospects for laser printing and trimming of optical waveguide components and circuits.

  3. Stochastic convex sparse principal component analysis.

    PubMed

    Baytas, Inci M; Lin, Kaixiang; Wang, Fei; Jain, Anil K; Zhou, Jiayu

    2016-12-01

    Principal component analysis (PCA) is a dimensionality reduction and data analysis tool commonly used in many areas. The main idea of PCA is to represent high-dimensional data with a few representative components that capture most of the variance present in the data. However, there is an obvious disadvantage of traditional PCA when it is applied to analyze data where interpretability is important. In applications, where the features have some physical meanings, we lose the ability to interpret the principal components extracted by conventional PCA because each principal component is a linear combination of all the original features. For this reason, sparse PCA has been proposed to improve the interpretability of traditional PCA by introducing sparsity to the loading vectors of principal components. The sparse PCA can be formulated as an ℓ1 regularized optimization problem, which can be solved by proximal gradient methods. However, these methods do not scale well because computation of the exact gradient is generally required at each iteration. Stochastic gradient framework addresses this challenge by computing an expected gradient at each iteration. Nevertheless, stochastic approaches typically have low convergence rates due to the high variance. In this paper, we propose a convex sparse principal component analysis (Cvx-SPCA), which leverages a proximal variance reduced stochastic scheme to achieve a geometric convergence rate. We further show that the convergence analysis can be significantly simplified by using a weak condition which allows a broader class of objectives to be applied. The efficiency and effectiveness of the proposed method are demonstrated on a large-scale electronic medical record cohort.

  4. Two-component Bose gases under rotation

    SciTech Connect

    Bargi, S.; Kaerkkaeinen, K.; Christensson, J.; Reimann, S. M.; Kavoulakis, G. M.; Manninen, M.

    2008-04-04

    We examine the formation of vortices in a one- and two-component gas of bosonic atoms in a harmonic trap that is set rotating. Both the mean-field Gross-Pitaevskii approach, and the numerical diagonalization method are employed. For a two-component Bose gas, we show that beside the well-known coreless vortices of single quantization, the interatomic interactions between the two species may lead to coreless vortices of multiple quantization. We furthermore comment on the geometries of the interlaced vortex patterns. In the limit of weak interactions, we finally demonstrate a number of exact results.

  5. Loaded Transducer Fpr Downhole Drilling Component

    DOEpatents

    Hall, David R.; Hall, H. Tracy; Pixton, David; Dahlgren, Scott; Sneddon, Cameron; Briscoe, Michael; Fox, Joe

    2005-07-05

    A robust transmission element for transmitting information between downhole tools, such as sections of drill pipe, in the presence of hostile environmental conditions, such as heat, dirt, rocks, mud, fluids, lubricants, and the like. The transmission element maintains reliable connectivity between transmission elements, thereby providing an uninterrupted flow of information between drill string components. A transmission element is mounted within a recess proximate a mating surface of a downhole drilling component, such as a section of drill pipe. To close gaps present between transmission elements, transmission elements may be biased with a "spring force," urging them closer together.

  6. Loaded transducer for downhole drilling components

    DOEpatents

    Hall, David R.; Hall, Jr., H. Tracy; Pixton, David S.; Briscoe, Michael A.; Dahlgren, Scott Steven; Fox, Joe; Sneddon, Cameron

    2006-02-21

    A robust transmission element for transmitting information between downhole tools, such as sections of drill pipe, in the presence of hostile environmental conditions, such as heat, dirt, rocks, mud, fluids, lubricants, and the like. The transmission element maintains reliable connectivity between transmission elements, thereby providing an uninterrupted flow of information between drill string components. A transmission element is mounted within a recess proximate a mating surface of a downhole drilling component, such as a section of drill pipe. To close gaps present between transmission elements, transmission elements may be biased with a "spring force, urging them closer together."

  7. Effects of nutritional components on aging

    PubMed Central

    Lee, Dongyeop; Hwang, Wooseon; Artan, Murat; Jeong, Dae-Eun; Lee, Seung-Jae

    2015-01-01

    Nutrients including carbohydrates, proteins, lipids, vitamins, and minerals regulate various physiological processes and are essential for the survival of organisms. Reduced overall caloric intake delays aging in various organisms. However, the role of each nutritional component in the regulation of lifespan is not well established. In this review, we describe recent studies focused on the regulatory role of each type of nutrient in aging. Moreover, we will discuss how the amount or composition of each nutritional component may influence longevity or health in humans. PMID:25339542

  8. Component research for future propulsion systems

    NASA Technical Reports Server (NTRS)

    Walker, C. L.; Weden, G. J.; Zuk, J.

    1981-01-01

    Factors affecting the helicopter market are reviewed. The trade-offs involving acquisition cost, mission reliability, and life cycle cost are reviewed, including civil and military aspects. The potential for advanced vehicle configurations with substantial improvements in energy efficiency, operating economics, and characteristics to satisfy the demands of the future market are identified. Advanced propulsion systems required to support these vehicle configurations are discussed, as well as the component technology for the engine systems. Considerations for selection of components in areas of economics and efficiency are presented.

  9. Parameterizable Library Components for SAW Devices

    NASA Technical Reports Server (NTRS)

    Wilson, William C.; Atkinson, Gary M.

    2006-01-01

    To facilitate quick fabrication of Surface Acoustic Wave (SAW) sensors we have found it necessary to develop a library of parameterizable components. This library is the first module in our strategy towards a design tool that is integrated into existing Electronic Design Automation (EDA) tools. This library is similar to the standard cell libraries found in digital design packages. The library cells allow the user to input the design parameters which automatically generate a detailed layout of the SAW component. This paper presents the results of our development of parameterizable cells for an InterDigitated Transducer (IDT), reflector, SAW delay line, and both one and two port resonators.

  10. Investigations into High Temperature Components and Packaging

    SciTech Connect

    Marlino, L.D.; Seiber, L.E.; Scudiere, M.B.; M.S. Chinthavali, M.S.; McCluskey, F.P.

    2007-12-31

    The purpose of this report is to document the work that was performed at the Oak Ridge National Laboratory (ORNL) in support of the development of high temperature power electronics and components with monies remaining from the Semikron High Temperature Inverter Project managed by the National Energy Technology Laboratory (NETL). High temperature electronic components are needed to allow inverters to operate in more extreme operating conditions as required in advanced traction drive applications. The trend to try to eliminate secondary cooling loops and utilize the internal combustion (IC) cooling system, which operates with approximately 105 C water/ethylene glycol coolant at the output of the radiator, is necessary to further reduce vehicle costs and weight. The activity documented in this report includes development and testing of high temperature components, activities in support of high temperature testing, an assessment of several component packaging methods, and how elevated operating temperatures would impact their reliability. This report is organized with testing of new high temperature capacitors in Section 2 and testing of new 150 C junction temperature trench insulated gate bipolar transistor (IGBTs) in Section 3. Section 4 addresses some operational OPAL-GT information, which was necessary for developing module level tests. Section 5 summarizes calibration of equipment needed for the high temperature testing. Section 6 details some additional work that was funded on silicon carbide (SiC) device testing for high temperature use, and Section 7 is the complete text of a report funded from this effort summarizing packaging methods and their reliability issues for use in high temperature power electronics. Components were tested to evaluate the performance characteristics of the component at different operating temperatures. The temperature of the component is determined by the ambient temperature (i.e., temperature surrounding the device) plus the

  11. Principal Component Analysis of Brown Dwarfs

    NASA Astrophysics Data System (ADS)

    Cleary, Colleen; Rodriguez, David

    2017-01-01

    Principal component analysis is a technique for reducing variables and emphasizing patterns in a data set. In this study, the data set consisted of the attributes of 174 brown dwarfs. The PCA was performed on several photometric measurements in near-infrared wavelengths and colors in order to determine if these variables showed a correlation with the physical parameters. This research resulted in two separate models that predict luminosity and temperature. The application of principal component analysis on the near-infrared photometric measurements and colors of brown dwarfs, along with models, provides alternate methods for predicting the luminosity and temperature of brown dwarfs using only photometric measurements.

  12. Multi-Component Reactions in Heterocyclic Chemistry

    NASA Astrophysics Data System (ADS)

    Müller, Thomas J. J.; Orru, Romano V. A.; Chebanov, Valentin A.; Sakhno, Yana I.; Saraev, Vyacheslav E.; Muravyova, Elena A.; Andrushchenko, Anastasia Yu.; Desenko, Sergey M.; Akhmetova, V. R.; Khabibullina, G. R.; Rakhimova, E. B.; Vagapov, R. A.; Khairullina, R. R.; Niatshina, Z. T.; Murzakova, N. N.; Maslivets, Andrey N.; Voskressensky, Leonid G.; Danagulyan, Gevorg G.; Murtchyan, Armen D.; Tumanyan, Araksya K.; Banfi, Luca; Basso, Andrea; de Moliner, Fabio; Guanti, Giuseppe; Petricci, Elena; Riva, Renata; Taddei, Maurizio; Naimi-Jamal, M. Reza; Mashkouri, Sara; Sharifi, Ali; Przhevalski, Nikolai M.; Rozhkova, Elena N.; Tokmakov, Gennadii P.; Magedov, Igor V.; Armisheva, M. N.; Rassudihina, N. A.; Vahrin, M. I.; Gein, V. L.; Shaabani, Ahmad; Rezayan, Ali Hossein; Sarvary, Afshin; Heidary, Marjan; Ng, Seik Weng; Beliaev, Nikolai A.; Mokrushin, Vladimir S.; Paramonov, Igor V.; Ilyin, Alexey; Garkushenko, Anna K.; Dushek, Maria A.; Sagitullina, Galina P.; Sagitullin, Reva S.; Kysil, Volodymyr; Khvat, Alexander; Tsirulnikov, Sergey; Tkachenko, Sergey; Ivachtchenko, Alexandre; Gein, Vladimir L.; Panova, Olga S.; Ilyn, Alexey P.; Kravchenko, Dmitri V.; Potapov, Victor V.; Ivachtchenko, Alexandre V.; Vichegjanina, V. N.; Levandovskaya, E. B.; Gein, V. L.; Vahrin, M. I.; Vladimirov, I. N.; Zorina, A. A.; Nosova, N. V.; Gein, V. L.; Fedorova, O. V.; Vahrin, M. I.

    Multi-component and domino reactions are efficient and effective methods in the sustainable and diversity-oriented synthesis of heterocycles. In particular, transition metal-catalyzed multi-component sequences have recently gained considerable interest. Based upon the Sonogashira entry to alkynones, alkenones, and intermediate allenes, we have opened new avenues to the one-pot synthesis of numerous classes of heterocyclic frameworks in an MCR fashion. This methodological approach has now found various applications in one-pot syntheses of functional chromophores, pharmaceutically active compounds, and marine alkaloids and derivatives.

  13. Three-component laser anemometer measurement systems

    NASA Technical Reports Server (NTRS)

    Goldman, Louis J.

    1991-01-01

    A brief overview of the different laser anemometer (LA) optical designs available is presented. Then, the LA techniques that can be used to design a three-component measurement system for annular geometries are described. Some of the facility design considerations unique to these LA systems are also addressed. Following this, the facilities and the LA systems that were used to successfully measure the three components of velocity in the blading of annular-flow machines are reviewed. Finally, possible LA system enhancements and future research directions are presented.

  14. Improved components for engine fuel savings

    NASA Technical Reports Server (NTRS)

    Antl, R. J.; Mcaulay, J. E.

    1980-01-01

    NASA programs for developing fuel saving technology include the Engine Component Improvement Project for short term improvements in existing air engines. The Performance Improvement section is to define component technologies for improving fuel efficiency for CF6, JT9D and JT8D turbofan engines. Sixteen concepts were developed and nine were tested while four are already in use by airlines. If all sixteen concepts are successfully introduced the gain will be fuel savings of more than 6 billion gallons over the lifetime of the engines. The improvements include modifications in fans, mounts, exhaust nozzles, turbine clearance and turbine blades.

  15. Damage Tolerance Concepts for Critical Engine Components.

    DTIC Science & Technology

    1985-10-01

    18 (1984), 1235-1240. 21. James M.N. and Knott J.F., An assessment of crack closure and the extent of the short crack regime in QIN ( HY80 ) steel ...STRUCTURAL COMPONENTS OF A IEDIUM CARBON STEEL AND A MEDIUM-STRENGTH AL-Mg ALLOY by C.M.Branco 7 MANUFACTURINGTECHNOLOGY FOR NONDESTRUCTIVE EVALUATION-(NDE...ACCEPTANCE METHODS IN STRUCTURAL L COMPONENTS OF A MEDIUM CARBON STEEL AND A MEDIUM STRENGTH AL-Mg ALLOY "’" by %" C.M.Branco Professor UNIVERSITY OF MINHO

  16. Software Management Environment (SME): Components and algorithms

    NASA Technical Reports Server (NTRS)

    Hendrick, Robert; Kistler, David; Valett, Jon

    1994-01-01

    This document presents the components and algorithms of the Software Management Environment (SME), a management tool developed for the Software Engineering Branch (Code 552) of the Flight Dynamics Division (FDD) of the Goddard Space Flight Center (GSFC). The SME provides an integrated set of visually oriented experienced-based tools that can assist software development managers in managing and planning software development projects. This document describes and illustrates the analysis functions that underlie the SME's project monitoring, estimation, and planning tools. 'SME Components and Algorithms' is a companion reference to 'SME Concepts and Architecture' and 'Software Engineering Laboratory (SEL) Relationships, Models, and Management Rules.'

  17. Advanced NDE Technologies for Powder Metal Components

    SciTech Connect

    Martin, P; Haskins, J; Thomas, G; Dolan, K

    2003-05-01

    Nondestructive evaluation encompasses numerous technologies that assess materials and determine important properties. This paper demonstrates the applicability of several of these technologies to the field of powder metallurgy. The usual application of nondestructive evaluation is to detect and quantify defects in fully sintered product. But probably its most appealing role is to sense problems earlier in the manufacturing process to avoid making defects at all. Also nondestructive evaluation can be incorporated into the manufacturing processes to monitor important parameters and control the processes to produce defect free product. Nondestructive evaluation can characterize powders, evaluate components in the green state, monitor the sintering process, and inspect the final component.

  18. Complex principal components for robust motion estimation.

    PubMed

    Mauldin, F William; Viola, Francesco; Walker, William F

    2010-11-01

    Bias and variance errors in motion estimation result from electronic noise, decorrelation, aliasing, and inherent algorithm limitations. Unlike most error sources, decorrelation is coherent over time and has the same power spectrum as the signal. Thus, reducing decorrelation is impossible through frequency domain filtering or simple averaging and must be achieved through other methods. In this paper, we present a novel motion estimator, termed the principal component displacement estimator (PCDE), which takes advantage of the signal separation capabilities of principal component analysis (PCA) to reject decorrelation and noise. Furthermore, PCDE only requires the computation of a single principal component, enabling computational speed that is on the same order of magnitude or faster than the commonly used Loupas algorithm. Unlike prior PCA strategies, PCDE uses complex data to generate motion estimates using only a single principal component. The use of complex echo data is critical because it allows for separation of signal components based on motion, which is revealed through phase changes of the complex principal components. PCDE operates on the assumption that the signal component of interest is also the most energetic component in an ensemble of echo data. This assumption holds in most clinical ultrasound environments. However, in environments where electronic noise SNR is less than 0 dB or in blood flow data for which the wall signal dominates the signal from blood flow, the calculation of more than one PC is required to obtain the signal of interest. We simulated synthetic ultrasound data to assess the performance of PCDE over a wide range of imaging conditions and in the presence of decorrelation and additive noise. Under typical ultrasonic elasticity imaging conditions (0.98 signal correlation, 25 dB SNR, 1 sample shift), PCDE decreased estimation bias by more than 10% and standard deviation by more than 30% compared with the Loupas method and normalized

  19. Volatile components from selected Tahitian liverworts.

    PubMed

    Ludwiczuk, Agnieszka; Komala, Ismiarni; Pham, André; Bianchini, Jean-Pierre; Raharivelomanana, Phila; Asakawa, Yoshinori

    2009-10-01

    Six Tahitian liverworts, Trichocolea pluma, Chandonanthus hirtellus, Mastigophora diclados, Jungermannia sp., Plagiochila sp. and Cyathodium foetidissimum were chemically investigated. All of these liverworts produce their own characteristic compounds. Vanillic acid methyl ester was isolated for the first time from T. pluma. Skatol is responsible for the very intense unpleasant odor of C. foetidissimum. Herbertane-type sesquiterpenoids are peculiar components of M. diclados, and fusicoccane-type diterpenoids were identified in Pagiochila sp. Cembranes and ent-verticillanes were isolated from C. hirtellus and also detected in Jungermannia species. C. hirtellus also biosynthesizes algal components and such results may suggest that some liverworts originate from algae.

  20. Building Reusable Software Components for Automated Retrieval

    DTIC Science & Technology

    1992-09-01

    Audtor: William C. Hoppe --Date: 7 November 1991 --Revised: --Course: CS4530 -System: SUN -3 UNIX --Compiler: Verdix Ada, VADS, Ver 6.0 --Description...USE simple...expression ; recordj~epresentation-clause FOR IDENTIF1ER USE RECORD aligment clauses component-clauses EN RCRD; alignmeriLclauses

  1. Haitian Component Bibliography. Migrant Heritage Studies Kit.

    ERIC Educational Resources Information Center

    Roark-Calnek, Sue, Comp.

    This 587-item annotated bibliography, designed as a supplement to the Haitian Component of the Migrant Heritage Studies Kit, provides access to additional information, including audiovisual materials, on resources on Haiti and Haitian immigrants, published between 1877 and 1984. Part I is a "General Bibliography" which includes 313…

  2. Oxygen Compatibility Assessment of Components and Systems

    NASA Technical Reports Server (NTRS)

    Stoltzfus, Joel; Sparks, Kyle

    2010-01-01

    Fire hazards are inherent in oxygen systems and a storied history of fires in rocket engine propulsion components exists. To detect and mitigate these fire hazards requires careful, detailed, and thorough analyses applied during the design process. The oxygen compatibility assessment (OCA) process designed by NASA Johnson Space Center (JSC) White Sands Test Facility (WSTF) can be used to determine the presence of fire hazards in oxygen systems and the likelihood of a fire. This process may be used as both a design guide and during the approval process to ensure proper design features and material selection. The procedure for performing an OCA is a structured step-by-step process to determine the most severe operating conditions; assess the flammability of the system materials at the use conditions; evaluate the presence and efficacy of ignition mechanisms; assess the potential for a fire to breach the system; and determine the reaction effect (the potential loss of life, mission, and system functionality as the result of a fire). This process should be performed for each component in a system. The results of each component assessment, and the overall system assessment, should be recorded in a report that can be used in the short term to communicate hazards and their mitigation and to aid in system/component development and, in the long term, to solve anomalies that occur during engine testing and operation.

  3. Balancing rations to optimize milk components

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Mammalian milk contains a multitude of components that are important in providing the nutritional requirements of the developing offspring. Whereas the primary selective pressure for the vast majority of mammalian milk composition comes from the ability to meet the nutritional requirements for healt...

  4. 49 CFR 228.203 - Program components.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... QUARTERS Electronic Recordkeeping § 228.203 Program components. (a) System security. The integrity of the program and database must be protected by a security system that utilizes an employee identification... subcontractor to a railroad, may allow its recordkeeping system to pre-populate fields of the hours of...

  5. 49 CFR 228.203 - Program components.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... QUARTERS Electronic Recordkeeping § 228.203 Program components. (a) System security. The integrity of the program and database must be protected by a security system that utilizes an employee identification... subcontractor to a railroad, may allow its recordkeeping system to pre-populate fields of the hours of...

  6. Software Component Technologies and Space Applications

    NASA Technical Reports Server (NTRS)

    Batory, Don

    1995-01-01

    In the near future, software systems will be more reconfigurable than hardware. This will be possible through the advent of software component technologies which have been prototyped in universities and research labs. In this paper, we outline the foundations for those technologies and suggest how they might impact software for space applications.

  7. Monitoring femoral component installation using vibration testing.

    PubMed

    Giardini, Seana; Cornwell, Phillip; Meneghini, R Michael

    2005-01-01

    With emerging minimally invasive surgical techniques in total hip arthroplasty, there has been anecdotal evidence of an increase in fractures associated with the insertion of the prosthesis into the femur. The diminished visibility associated with minimally invasive surgical techniques necessitates a greater emphasis on the surgeon's tactile and auditory senses. These senses are used to ascertain the femoral component position of maximum stability and interference fit, as well as to prevent further component impaction and subsequent fracture of the femur. The work described herein attempts to identify a means to supplement the surgeon's tactile and auditory senses by using damage identification techniques normally used in civil and mechanical structures to monitor the insertion process of the prosthesis. It is hypothesized that vibration characteristics of the impact process may be used intraoperatively to determine at what position the femoral component has reached appropriate interference fit and stability in the femur. Such information may be used to prevent further impaction of the femoral component past a threshold that could result in a periprosthetic fracture. A piezoelectric accelerometer and impact hammer will be used to monitor the impact process. The acceleration time history data were analyzed by using low and high pass filters to allow frequency analysis of the time history signals. This paper will summarize features derived from the measured data that will be used to develop an insertion process termination indicator.

  8. [Studies on chemical components of Cirsium segestum].

    PubMed

    Zhou, Qing; Chen, Lin; Liu, Zhi-peng; Deng, Qin-ying

    2007-01-01

    Six chemical components were got from the alcohol extract of Cirsium segestum, their structures were identified by UV, IR, NMR, MS and EA. They were 5,7-dihydroxyflavone, baicalin, oleanolic acid, cholesterol, methyl ursolate and rutin. The first to the fifth of which were got from Cirsium segestum for the first time.

  9. Coal feed component testing for CDIF

    NASA Technical Reports Server (NTRS)

    Pearson, C. V.; Snyder, B. K.; Fornek, T. E.

    1977-01-01

    Investigations conducted during the conceptual design of the Montana MHD Component Development and Integration Facility (CDIF) identified commercially available processing and feeding equipment potentially suitable for use in a reference design. Tests on sub-scale units of this equipment indicated that they would perform as intended.

  10. New propulsion components for electric vehicles

    NASA Technical Reports Server (NTRS)

    Secunde, R. R.

    1982-01-01

    Improved component technology is described. This includes electronically commutated permanent magnet motors of both drum and disk configurations, an unconventional brush commutated motor, ac induction motors, various controllers, transmissions and complete systems. One or more of these approaches to electric vehicle propulsion may eventually displace presently used controllers and brush commutated dc motors.

  11. Circuit bridging of components by smoke

    SciTech Connect

    Tanaka, T.J.; Nowlen, S.P.; Anderson, D.J.

    1996-10-01

    Smoke can adversely affect digital electronics; in the short term, it can lead to circuit bridging and in the long term to corrosion of metal parts. This report is a summary of the work to date and component-level tests by Sandia National Laboratories for the Nuclear Regulatory Commission to determine the impact of smoke on digital instrumentation and control equipment. The component tests focused on short-term effects such as circuit bridging in typical components and the factors that can influence how much the smoke will affect them. These factors include the component technology and packaging, physical board protection, and environmental conditions such as the amount of smoke, temperature of burn, and humidity level. The likelihood of circuit bridging was tested by measuring leakage currents and converting those currents to resistance in ohms. Hermetically sealed ceramic packages were more resistant to smoke than plastic packages. Coating the boards with an acrylic spray provided some protection against circuit bridging. The smoke generation factors that affect the resistance the most are humidity, fuel level, and burn temperature. The use of CO{sub 2} as a fire suppressant, the presence of galvanic metal, and the presence of PVC did not significantly affect the outcome of these results.

  12. Low distortion laser welding of cylindrical components

    NASA Astrophysics Data System (ADS)

    Kittel, Sonja

    2011-02-01

    Automotive components are for the most part cylindrical and thus the weld seams are of radial shape. Radial weld seams are usually produced by starting at a point on the component's surface rotating the component resulting in an overlap zone at the start/end of the weld. In this research, it is shown that the component's distortion strongly depends on the overlap of weld start and end. A correlation between overlap zone and distortion is verified by an experimental study. In order to reduce distortion generated by the overlap zone a special optics is used which allows shaping the laser beam into a ring shape which is then focused on the cylindrical surface and produces a radial ring weld seam simultaneously by one laser pulse. In doing this, the overlap zone is eliminated and distortion can be reduced. Radial weld seams are applied on precision samples and distortion is measured after welding. The distortion of the precision samples is measured by a tactile measuring method and a comparison of the results of welding with the ring optics to reference welds is done.

  13. Low distortion laser welding of cylindrical components

    NASA Astrophysics Data System (ADS)

    Kittel, Sonja

    2010-09-01

    Automotive components are for the most part cylindrical and thus the weld seams are of radial shape. Radial weld seams are usually produced by starting at a point on the component's surface rotating the component resulting in an overlap zone at the start/end of the weld. In this research, it is shown that the component's distortion strongly depends on the overlap of weld start and end. A correlation between overlap zone and distortion is verified by an experimental study. In order to reduce distortion generated by the overlap zone a special optics is used which allows shaping the laser beam into a ring shape which is then focused on the cylindrical surface and produces a radial ring weld seam simultaneously by one laser pulse. In doing this, the overlap zone is eliminated and distortion can be reduced. Radial weld seams are applied on precision samples and distortion is measured after welding. The distortion of the precision samples is measured by a tactile measuring method and a comparison of the results of welding with the ring optics to reference welds is done.

  14. 21 CFR 890.3920 - Wheelchair component.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Wheelchair component. 890.3920 Section 890.3920 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3920...

  15. 21 CFR 890.3920 - Wheelchair component.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Wheelchair component. 890.3920 Section 890.3920 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3920...

  16. 21 CFR 890.3920 - Wheelchair component.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Wheelchair component. 890.3920 Section 890.3920 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3920...

  17. 24 CFR 585.3 - Program components.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT COMMUNITY FACILITIES YOUTHBUILD PROGRAM General § 585.3 Program components. A Youthbuild...; (4) Job development and placement activities and post-graduation follow-up assistance; and (5)...

  18. 24 CFR 585.3 - Program components.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT COMMUNITY FACILITIES YOUTHBUILD PROGRAM General § 585.3 Program components. A Youthbuild...; (4) Job development and placement activities and post-graduation follow-up assistance; and (5)...

  19. Principal component analysis of phenolic acid spectra

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Phenolic acids are common plant metabolites that exhibit bioactive properties and have applications in functional food and animal feed formulations. The ultraviolet (UV) and infrared (IR) spectra of four closely related phenolic acid structures were evaluated by principal component analysis (PCA) to...

  20. Low-Temperature Electronic Components Being Developed

    NASA Technical Reports Server (NTRS)

    Patterson, Richard L.; Hammond, Ahmad

    1999-01-01

    In many future NASA missions, such as deep space planetary exploration and the Next Generation Space Telescope, electrical components and systems must operate reliably and efficiently in extremely low temperature environments. Most modern electronic components cannot operate below moderately low operating temperatures (-40 to -55 C). The low-temperature electronics program at the NASA Lewis Research Center is focusing on the development and characterization of low-temperature components and the integration of the developed devices into demonstrable very low-temperature (-200 C) power systems such as dc-dc converters. Such low-temperature electronics will not only tolerate hostile environments but also will reduce system size and weight by eliminating radioisotope heating units, thereby reducing launch cost, improving reliability and lifetime, and increasing energy densities. Low-temperature electronic components will also have a great influence on terrestrial applications such as medical instrumentation, magnetic levitation transportation systems, and arctic and antarctic exploration. Lewis researchers are now performing extensive evaluations of commercially available as well as custom-made devices. These include various types of energy storage and signal capacitors, power switching devices, magnetic and superconducting materials, and primary lithium batteries, to name a few.

  1. Qualifying drillstring components for deep drilling

    SciTech Connect

    Hill, T.H.; Money, R.C.; Palmer, C.R.

    1984-04-01

    Deep, hard or directional drilling imposes extraordinary stresses on drill string components. Because of the additional economic risks of deep drilling, the use of drill string components should be based upon their compliance with API or user acceptance standards. Inspection procedures which provide the highest probability of finding and eliminating unacceptable components should also be employed. Often, too much reliance is placed on a ''report'' or ''certification'' that the drill string components have been ''inspected''. The operator assumes that because the material has been inspected, it is suitable for the intended service. This report addresses three areas in which the above approach leads to trouble: Widespread, established practices have resulted in many applicable API guidelines being unintentionally ignored by users and inspection companies. API standards for used drill pipe do not address some items which should concern operators engaged in deep or critical drilling. Inspection companies frequently do not follow simple quality control steps that can markedly improve the results of their work. Examples of shortcomings in present industry practices are given. Corrective actions which have been implemented by several companies in the last 12-18 months are also given. A hand held calculator program which will aid in evaluating the wear limits on rotary shouldered connections is provided in the appendix to this paper.

  2. The Underlying Components of Clinical Teaching.

    ERIC Educational Resources Information Center

    Romberg, Elaine; Metzger, Cheryl

    Student ratings of dental hygiene clinical instruction were analyzed to determine dimensions of clinical instruction and the effect of the faculty's teaching philosophy on the underlying components of teaching. A 31-item student evaluation instrument was developed to reflect the teaching philosophy of the Department of Dental Hygiene, University…

  3. 42 CFR 93.209 - Funding component.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Funding component. 93.209 Section 93.209 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON...

  4. Instructional Components of Mediational Dynamic Assessment.

    ERIC Educational Resources Information Center

    Symons, Sonya E.; Vye, Nancy J.

    The instructional components of mediation, a teaching technique used in dynamic assessment, were evaluated with 100 four-year-old children attending daycare or preschools in London, Ontario. The effects of familiarization with task materials, task-specific rule teaching, and elaborated feedback were assessed using a pretest-posttest design.…

  5. 21 CFR 890.3920 - Wheelchair component.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Wheelchair component. 890.3920 Section 890.3920 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3920...

  6. 21 CFR 890.3920 - Wheelchair component.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Wheelchair component. 890.3920 Section 890.3920 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3920...

  7. 49 CFR 228.203 - Program components.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Program components. 228.203 Section 228.203 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HOURS OF SERVICE OF RAILROAD EMPLOYEES; RECORDKEEPING AND REPORTING;...

  8. Integration of Media Components for Successful Teleconferencing.

    ERIC Educational Resources Information Center

    Hancock, Burton W.; And Others

    For a teleconference to be successful, presentations need to be both interesting and educational. The integration of media components such as slide, overhead transparencies, videotapes, or handouts in an audio teleconference expands a single-channel presentation into a multi-sensory channel presentation. The selection and utilization of such media…

  9. Shape optimization of tibial prosthesis components

    NASA Technical Reports Server (NTRS)

    Saravanos, D. A.; Mraz, P. J.; Davy, D. T.

    1993-01-01

    NASA technology and optimal design methodologies originally developed for the optimization of composite structures (engine blades) are adapted and applied to the optimization of orthopaedic knee implants. A method is developed enabling the shape tailoring of the tibial components of a total knee replacement implant for optimal interaction within the environment of the tibia. The shape of the implant components are optimized such that the stresses in the bone are favorably controlled to minimize bone degradation, to improve the mechanical integrity of the implant/interface/bone system, and to prevent failures of the implant components. A pilot tailoring system is developed and the feasibility of the concept is demonstrated and evaluated. The methodology and evolution of the existing aerospace technology from which this pilot optimization code was developed is also presented and discussed. Both symmetric and unsymmetric in-plane loading conditions are investigated. The results of the optimization process indicate a trend toward wider and tapered posts as well as thicker backing trays. Unique component geometries were obtained for the different load cases.

  10. New propulsion components for electric vehicles

    NASA Technical Reports Server (NTRS)

    Secunde, R. R.

    1983-01-01

    Improved component technology is described. This includes electronically commutated permanent magnet motors of both drum and disk configurations, an unconventional brush commutated motor, ac induction motors, various controllers, transmissions and complete systems. One or more of these approaches to electric vehicle propulsion may eventually displace presently used controllers and brush commutated dc motors. Previously announced in STAR as N83-25982

  11. Time Components of the Left Ventricle.

    ERIC Educational Resources Information Center

    Franks, B. Don

    The purpose of this study was to examine the relationship of the time components of the left ventricle. Since one of the ways to investigate cardiac function is to analyze the time intervals between particular events of the cardiac cycle, various time intervals of systole and diastole of the left ventricle were measured from simultaneous…

  12. Carbohydrates as enantioinduction components in stereoselective catalysis

    PubMed Central

    Henderson, Alexander S.

    2016-01-01

    Carbohydrate derivatives are readily available chiral molecules, yet they are infrequently employed as enantioinduction components in stereoselective catalysis. In this review, synthetic approaches to carbohydrate-based ligands and catalysts are outlined, along with example applications in enantioselective catalysis. A wide range of carbohydrate-based functionality is covered, and key trends and future opportunities are identified. PMID:27064817

  13. Advanced Placement: Model Policy Components. Policy Analysis

    ERIC Educational Resources Information Center

    Zinth, Jennifer

    2016-01-01

    Advanced Placement (AP), launched in 1955 by the College Board as a program to offer gifted high school students the opportunity to complete entry-level college coursework, has since expanded to encourage a broader array of students to tackle challenging content. This Education Commission of the State's Policy Analysis identifies key components of…

  14. Flow Forming of Aircraft Engine Components

    DTIC Science & Technology

    2006-05-01

    Canada 1000 Marie Victorin, Longueuil Québec J4G 1A1 CANADA jean.Savoie@pwc.ca ABSTRACT Aircraft engine components are often an assembly of...1000 Marie Victorin, Longueuil Québec J4G 1A1 CANADA 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES

  15. 21 CFR 226.42 - Components.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Components. 226.42 Section 226.42 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR TYPE A MEDICATED ARTICLES Product Quality Control §...

  16. 21 CFR 225.142 - Components.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Components. 225.142 Section 225.142 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Product Quality Assurance § 225.142...

  17. A new component of the Fraser complex.

    PubMed

    Hiroyasu, Sho; Jones, Jonathan C R

    2014-05-01

    In embryos, the Fraser complex (FC) mediates epithelial-connective tissue interactions. Loss of expression of FC components leads to Fraser syndrome (FS), in which cohesion of epithelial tissues and stroma is perturbed. Using zebrafish, Richardson et al. (this issue) identified the protein AMACO in the FC. We discuss the utility of zebrafish in determining FC functions and identifying FS targets.

  18. New engine and advanced component design

    SciTech Connect

    Not Available

    1990-01-01

    This book contains the proceedings on new engine and advance component design. Topics covered include: development of low emission high performance four valve engines, the effect of engine build options on powerplant inertias, silicon nitride turbocharger rotor for high performance automotive engines and development of Toyota reflex Burn (TRB) system in DI diesel.

  19. Functional Color Components Used in Reading Instruction.

    ERIC Educational Resources Information Center

    Sassenrath, Julius M.; And Others

    1979-01-01

    A group of 190 third through sixth graders were given either 6, 16, or 26 months of reading instruction with functional color components (FCC) of parts of words. Another 160 children in the same schools did not recieve FCC instruction. FCC brought about improvement in reading scores. Nondisability children showed greater improvement. (Author)

  20. Confinement of reaction components at electrode surface

    DOEpatents

    Luca, Oana R.; Weitekamp, Raymond; Grubbs, Robert H.; Atwater, Harry A.; Mitrovic, Slobodan

    2017-03-14

    A CO.sub.2 reduction electrode includes an active layer on an electrode base. The active layer includes a polymer that includes one or more reaction components selected from a group consisting of a CO.sub.2 reduction catalyst and an activator that bonds CO.sub.2 so as to form a CO.sub.2 reduction intermediate.

  1. Component Latent Trait Models for Test Design.

    ERIC Educational Resources Information Center

    Embretson, Susan Whitely

    Latent trait models are presented that can be used for test design in the context of a theory about the variables that underlie task performance. Examples of methods for decomposing and testing hypotheses about the theoretical variables in task performance are given. The methods can be used to determine the processing components that are involved…

  2. Microwave heat treating of manufactured components

    DOEpatents

    Ripley, Edward B.

    2007-01-09

    An apparatus for heat treating manufactured components using microwave energy and microwave susceptor material. Heat treating medium such as eutectic salts may be employed. A fluidized bed introduces process gases which may include carburizing or nitriding gases. The process may be operated in a batch mode or continuous process mode. A microwave heating probe may be used to restart a frozen eutectic salt bath.

  3. Ion beam figuring of small optical components

    NASA Astrophysics Data System (ADS)

    Drueding, Thomas W.; Fawcett, Steven C.; Wilson, Scott R.; Bifano, Thomas G.

    1995-12-01

    Ion beam figuring provides a highly deterministic method for the final precision figuring of optical components with advantages over conventional methods. The process involves bombarding a component with a stable beam of accelerated particles that selectively removes material from the surface. Figure corrections are achieved by rastering the fixed-current beam across the workplace at appropriate, time-varying velocities. Unlike conventional methods, ion figuring is a noncontact technique and thus avoids such problems as edge rolloff effects, tool wear, and force loading of the workpiece. This work is directed toward the development of the precision ion machining system at NASA's Marshall Space Flight Center. This system is designed for processing small (approximately equals 10-cm diam) optical components. Initial experiments were successful in figuring 8-cm-diam fused silica and chemical-vapor-deposited SiC samples. The experiments, procedures, and results of figuring the sample workpieces to shallow spherical, parabolic (concave and convex), and non-axially-symmetric shapes are discussed. Several difficulties and limitations encountered with the current system are discussed. The use of a 1-cm aperture for making finer corrections on optical components is also reported.

  4. 21 CFR 225.42 - Components.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... inventory control for all such drugs to aid in assuring their identity, strength, quality, and purity when incorporated into products. (b) The receipt, storage, and inventory of drugs, including undiluted drug... CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Product Quality Control § 225.42 Components. (a)...

  5. Overview of Glenn Mechanical Components Branch Research

    NASA Astrophysics Data System (ADS)

    Zakrajsek, James

    2002-09-01

    Mr. James Zakrajsek, chief of the Mechanical Components Branch, gave an overview of research conducted by the branch. Branch members perform basic research on mechanical components and systems, including gears and bearings, turbine seals, structural and thermal barrier seals, and space mechanisms. The research is focused on propulsion systems for present and advanced aerospace vehicles. For rotorcraft and conventional aircraft, we conduct research to develop technology needed to enable the design of low noise, ultra safe geared drive systems. We develop and validate analytical models for gear crack propagation, gear dynamics and noise, gear diagnostics, bearing dynamics, and thermal analyses of gear systems using experimental data from various component test rigs. In seal research we develop and test advanced turbine seal concepts to increase efficiency and durability of turbine engines. We perform experimental and analytical research to develop advanced thermal barrier seals and structural seals for current and next generation space vehicles. Our space mechanisms research involves fundamental investigation of lubricants, materials, components and mechanisms for deep space and planetary environments.

  6. Agile Objects: Component-Based Inherent Survivability

    DTIC Science & Technology

    2003-12-01

    We design, implement, and develop a component middleware system which enables online application reconfiguration to enhance application...Objects project has accomplished a basic proof of concept of the key project ideas showing working systems that embody location independence and online ...migration, open real-time structures and pre-allocation of resources to enable rapid migration, online interface mutation for elusive interfaces, and

  7. The solvent component of macromolecular crystals

    SciTech Connect

    Weichenberger, Christian X.; Kantardjieff, Katherine; Rupp, Bernhard

    2015-04-30

    On average, the mother liquor or solvent and its constituents occupy about 50% of a macromolecular crystal. Ordered as well as disordered solvent components need to be accurately accounted for in modelling and refinement, often with considerable complexity. The mother liquor from which a biomolecular crystal is grown will contain water, buffer molecules, native ligands and cofactors, crystallization precipitants and additives, various metal ions, and often small-molecule ligands or inhibitors. On average, about half the volume of a biomolecular crystal consists of this mother liquor, whose components form the disordered bulk solvent. Its scattering contributions can be exploited in initial phasing and must be included in crystal structure refinement as a bulk-solvent model. Concomitantly, distinct electron density originating from ordered solvent components must be correctly identified and represented as part of the atomic crystal structure model. Herein, are reviewed (i) probabilistic bulk-solvent content estimates, (ii) the use of bulk-solvent density modification in phase improvement, (iii) bulk-solvent models and refinement of bulk-solvent contributions and (iv) modelling and validation of ordered solvent constituents. A brief summary is provided of current tools for bulk-solvent analysis and refinement, as well as of modelling, refinement and analysis of ordered solvent components, including small-molecule ligands.

  8. Metal binding components in human amniotic fluid

    SciTech Connect

    Paterson, P.G.; Zlotkin, S.H.; Sarkar, B. )

    1990-02-26

    Amniotic fluid is a potential source of both nutritionally essential and toxic metals for the fetus. As the binding pattern of these metals in amniotic fluid may be one of the determining factors in their availability to the fetus, the objective of this study was to investigate metal binding in vitro. The binding of six trace metals, Mn(II), Ni(II), Zn(II), Cu(II), Cd(II), and Fe(III), to components of human amniotic fluid was studied by Sephadex G-100 gel filtration at physiological pH, using radioisotopes as tracers and 50 mM TRIS/HCl as the elution buffer. The amniotic fluid was collected at 16-16.5 weeks gestation by amniocentesis and pooled for analysis. Extensive amounts of Fe, Cu, Zn, and Cd and small amounts of Mn and Ni were bound to high molecular weight proteins with elution patterns similar to those seen for the binding of these metals in serum. In addition, large amounts of Fe, Mn, Ni and Cd and small amounts of Zn and Cu were associated with low molecular weight component(s). The identity of these latter components is unknown, but they play an important biological role in amniotic fluid.

  9. Compression Strength of Composite Primary Structural Components

    NASA Technical Reports Server (NTRS)

    Johnson, Eric R.

    1998-01-01

    Research conducted under NASA Grant NAG-1-537 focussed on the response and failure of advanced composite material structures for application to aircraft. Both experimental and analytical methods were utilized to study the fundamental mechanics of the response and failure of selected structural components subjected to quasi-static loads. Most of the structural components studied were thin-walled elements subject to compression, such that they exhibited buckling and postbuckling responses prior to catastrophic failure. Consequently, the analyses were geometrically nonlinear. Structural components studied were dropped-ply laminated plates, stiffener crippling, pressure pillowing of orthogonally stiffened cylindrical shells, axisymmetric response of pressure domes, and the static crush of semi-circular frames. Failure of these components motivated analytical studies on an interlaminar stress postprocessor for plate and shell finite element computer codes, and global/local modeling strategies in finite element modeling. These activities are summarized in the following section. References to literature published under the grant are listed on pages 5 to 10 by a letter followed by a number under the categories of journal publications, conference publications, presentations, and reports. These references are indicated in the text by their letter and number as a superscript.

  10. Complexities of One-Component Phase Diagrams

    ERIC Educational Resources Information Center

    Ciccioli, Andrea; Glasser, Leslie

    2011-01-01

    For most materials, the solid at and near the triple-point temperature is denser than the liquid with which it is in equilibrium. However, for water and certain other materials, the densities of the phases are reversed, with the solid being less dense. The profound consequences for the appearance of the "pVT" diagram of one-component materials…

  11. Liquid rocket metal tanks and tank components

    NASA Technical Reports Server (NTRS)

    Wagner, W. A.; Keller, R. B. (Editor)

    1974-01-01

    Significant guidelines are presented for the successful design of aerospace tanks and tank components, such as expulsion devices, standpipes, and baffles. The state of the art is reviewed, and the design criteria are presented along with recommended practices. Design monographs are listed.

  12. Critical Propulsion Components. Volume 2; Combustor

    NASA Technical Reports Server (NTRS)

    2005-01-01

    Several studies have concluded that a supersonic aircraft, if environmentally acceptable and economically viable, could successfully compete in the 21st century marketplace. However, before industry can commit to what is estimated as a 15 to 20 billion dollar investment, several barrier issues must be resolved. In an effort to address these barrier issues, NASA and Industry teamed to form the High-Speed Research (HSR) program. As part of this program, the Critical Propulsion Components (CPC) element was created and assigned the task of developing those propulsion component technologies necessary to: (1) reduce cruise emissions by a factor of 10 and (2) meet the ever-increasing airport noise restrictions with an economically viable propulsion system. The CPC-identified critical components were ultra-low emission combustors, low-noise/high-performance exhaust nozzles, low-noise fans, and stable/high-performance inlets. Propulsion cycle studies (coordinated with NASA Langley Research Center sponsored airplane studies) were conducted throughout this CPC program to help evaluate candidate components and select the best concepts for the more complex and larger scale research efforts. The propulsion cycle and components ultimately selected were a mixed-flow turbofan (MFTF) engine employing a lean, premixed, prevaporized (LPP) combustor coupled to a two-dimensional mixed compression inlet and a two-dimensional mixer/ejector nozzle. Due to the large amount of material presented in this report, it was prepared in four volumes; Volume 1: Summary, Introduction, and Team. Propulsion System Studies, Volume 2: Combustor, Volume 3: Exhaust Nozzle, and Volume 4: Inlet and Fan/Inlet Acoustic Team.

  13. Critical Propulsion Components. Volume 3; Exhaust Nozzle

    NASA Technical Reports Server (NTRS)

    2005-01-01

    Several studies have concluded that a supersonic aircraft, if environmentally acceptable and economically viable, could successfully compete in the 21st century marketplace. However, before industry can commit to what is estimated as a 15 to 20 billion dollar investment, several barrier issues must be resolved. In an effort to address these barrier issues, NASA and Industry teamed to form the High-Speed Research (HSR) program. As part of this program, the Critical Propulsion Components (CPC) element was created and assigned the task of developing those propulsion component technologies necessary to: (1) reduce cruise emissions by a factor of 10 and (2) meet the ever-increasing airport noise restrictions with an economically viable propulsion system. The CPC-identified critical components were ultra-low emission combustors, low-noise/high-performance exhaust nozzles, low-noise fans, and stable/high-performance inlets. Propulsion cycle studies (coordinated with NASA Langley Research Center sponsored airplane studies) were conducted throughout this CPC program to help evaluate candidate components and select the best concepts for the more complex and larger scale research efforts. The propulsion cycle and components ultimately selected were a mixed-flow turbofan (MFTF) engine employing a lean, premixed, prevaporized (LPP) combustor coupled to a two-dimensional mixed compression inlet and a two-dimensional mixer/ejector nozzle. Due to the large amount of material presented in this report, it was prepared in four volumes; Volume 1: Summary, Introduction, and Propulsion System Studies, Volume 2: Combustor, Volume 3: Exhaust Nozzle, and Volume 4: Inlet and Fan/Inlet Acoustic Team.

  14. Chemical separation of disc components using RAVE

    NASA Astrophysics Data System (ADS)

    Wojno, Jennifer; Kordopatis, Georges; Steinmetz, Matthias; McMillan, Paul; Matijevič, Gal; Binney, James; Wyse, Rosemary F. G.; Boeche, Corrado; Just, Andreas; Grebel, Eva K.; Siebert, Arnaud; Bienaymé, Olivier; Gibson, Brad K.; Zwitter, Tomaž; Bland-Hawthorn, Joss; Navarro, Julio F.; Parker, Quentin A.; Reid, Warren; Seabroke, George; Watson, Fred

    2016-10-01

    We present evidence from the RAdial Velocity Experiment (RAVE) survey of chemically separated, kinematically distinct disc components in the solar neighbourhood. We apply probabilistic chemical selection criteria to separate our sample into α-low (`thin disc') and α-high (`thick disc') sequences. Using newly derived distances, which will be utilized in the upcoming RAVE DR5, we explore the kinematic trends as a function of metallicity for each of the disc components. For our α-low disc, we find a negative trend in the mean rotational velocity (Vφ) as a function of iron abundance ([Fe/H]). We measure a positive gradient ∂Vφ/∂[Fe/H] for the α-high disc, consistent with results from high-resolution surveys. We also find differences between the α-low and α-high discs in all three components of velocity dispersion. We discuss the implications of an α-low, metal-rich population originating from the inner Galaxy, where the orbits of these stars have been significantly altered by radial mixing mechanisms in order to bring them into the solar neighbourhood. The probabilistic separation we propose can be extended to other data sets for which the accuracy in [α/Fe] is not sufficient to disentangle the chemical disc components a priori. For such data sets which will also have significant overlap with Gaia DR1, we can therefore make full use of the improved parallax and proper motion data as it becomes available to investigate kinematic trends in these chemical disc components.

  15. Public opinions on disclosure of tobacco components

    PubMed Central

    Yun, E Hwa; Park, Young-Ok; Lim, Min Kyung; Oh, Jin-Kyoung; Park, Eun Young; Jeong, Bo Yoon; Hong, Soon-Yeol; Lee, Do-Hoon

    2016-01-01

    Abstract This study aimed to explore public views on disclosure of tobacco components in an effort to develop a comprehensive regulatory system facilitating implementation of the Framework Convention on Tobacco Control (FCTC) Articles 9 and 10 in Korea. In all, 1200 representative Koreans 19 years old or older were enrolled and information on their general characteristics, smoking status, awareness of the effects of smoking on health, and views on the public disclosure of tobacco components was collected by telephone using a structured questionnaire. Factors associated with acceptance of the need for public disclosure of tobacco components were identified via multivariate analysis. Most participants considered it necessary to publicly disclose tobacco components (95.9%) and were aware of the risk to health posed by smoking (76.0%). The prevalent view was that tobacco companies should be legally required to publicly disclose details of the components of cigarettes, their levels per cigarette, and their effects on health. The most effective means of disclosure were considered to be the mass media, printed materials, and labels on cigarette packs. Females and never-smokers (odds ratio [OR]: 4.39, 95% confidence interval [95% CI]: 1.76–10.94) more readily accepted the need for public disclosure, whereas those of lower educational level and/or who were less aware of the harm to health posed by smoking (OR: 0.05, 95% CI: 0.01–0.18) were less likely to be accepting. The attitude of the general population ensures that FCTC Articles 9 and 10 will be successfully implemented in Korea. Further public consultation on the details of disclosure would be useful for the development of a comprehensive regulatory system. PMID:27399063

  16. Behavioral contrast for key pecking as a function of component duration when only one component varies

    PubMed Central

    McSweeney, Frances K.; Melville, Cam L.

    1993-01-01

    Pigeons pecked keys for food reinforcers delivered by multiple variable-interval 2-min variable-interval 2-min schedules. Positive behavioral contrast was created by changing one component to extinction; negative contrast was achieved by changing one component to a variable-interval 15-s schedule. The duration of each component was varied independently of the other from 5 to 960 s. The size of positive contrast was greatest when the extinction component was 30 or 60 s long. It did not change significantly with changes in the duration of the variable-interval 2-min component. The absolute size of negative contrast decreased with increases in the duration of the variable-interval 2-min component. It did not change significantly with changes in the duration of the variable-interval 15-s component. These results show that the size of contrast is determined primarily by the duration of the component that provides the less favorable conditions of reinforcement. These results are not predicted by current theories. PMID:16812701

  17. Enabling Technologies for Ceramic Hot Section Components

    SciTech Connect

    Venkat Vedula; Tania Bhatia

    2009-04-30

    Silicon-based ceramics are attractive materials for use in gas turbine engine hot sections due to their high temperature mechanical and physical properties as well as lower density than metals. The advantages of utilizing ceramic hot section components include weight reduction, and improved efficiency as well as enhanced power output and lower emissions as a result of reducing or eliminating cooling. Potential gas turbine ceramic components for industrial, commercial and/or military high temperature turbine applications include combustor liners, vanes, rotors, and shrouds. These components require materials that can withstand high temperatures and pressures for long duration under steam-rich environments. For Navy applications, ceramic hot section components have the potential to increase the operation range. The amount of weight reduced by utilizing a lighter gas turbine can be used to increase fuel storage capacity while a more efficient gas turbine consumes less fuel. Both improvements enable a longer operation range for Navy ships and aircraft. Ceramic hot section components will also be beneficial to the Navy's Growth Joint Strike Fighter (JSF) and VAATE (Versatile Affordable Advanced Turbine Engines) initiatives in terms of reduced weight, cooling air savings, and capability/cost index (CCI). For DOE applications, ceramic hot section components provide an avenue to achieve low emissions while improving efficiency. Combustors made of ceramic material can withstand higher wall temperatures and require less cooling air. Ability of the ceramics to withstand high temperatures enables novel combustor designs that have reduced NO{sub x}, smoke and CO levels. In the turbine section, ceramic vanes and blades do not require sophisticated cooling schemes currently used for metal components. The saved cooling air could be used to further improve efficiency and power output. The objectives of this contract were to develop technologies critical for ceramic hot section

  18. How Pure Components Control Polymer Blend Miscibility

    NASA Astrophysics Data System (ADS)

    White, Ronald; Lipson, Jane; Higgins, Julia

    2012-02-01

    We present insight into some intriguing relationships revealed by our recent studies of polymer mixture miscibility. Applying our simple lattice-based equation of state, we discuss some of the patterns observed over a sample of experimental blends. We focus on the question of how much key information can one determine from a knowledge of just the pure components only, and further, on the role of separate enthalpic and entropic contributions to the miscibility behavior. One interesting correlation connects the value of the difference in pure component energetic parameters with that of the mixed segment interactions, suggesting new possibilities for predictive modeling. We also show how in some cases these two parameter groupings act as separate controls determining the entropy and enthalpy of mixing. Also discussed are the different patterns exhibited for UCST-type and LCST-type blends, these being revealed in some cases by simple examination of the underlying microscopic parameters.

  19. Human reliability program: Components and effects

    SciTech Connect

    Baley-Downes, S.

    1986-01-01

    The term ''Human Reliability Program'' (HRP) is defined as a series of selective controls which are implemented and integrated to identify the ''insider threat'' from current and prospective employees who are dishonest, disloyal and unreliable. The HRP, although not a prediction of human behaviour, is an excellent tool for decision making and should compliment security and improve employee quality. The HRP consists of several component applications such as management evaluation; appropriate background investigative requirements; occupational health examination and laboratory testing; drug/alcohol screening; psychological testing and interviews; polygraph examination; job related aberrant behaviour recognition; on-going education and training; document control; drug/alcohol rehabilitation; periodic HRP audit; and implementation of an onsite central clearing house. The components and effects of HRP are discussed in further detail in this paper.

  20. Machine condition monitoring using principal component representations

    NASA Astrophysics Data System (ADS)

    He, Qingbo; Yan, Ruqiang; Kong, Fanrang; Du, Ruxu

    2009-02-01

    The purpose of this paper is to find the low-dimensional principal component (PC) representations from the statistical features of the measured signals to characterize and hence, monitor machine conditions. The PC representations can be automatically extracted using the principal component analysis (PCA) technique from the time- and frequency-domains statistical features of the measured signals. First, a mean correlation rule is proposed to evaluate the capability of each of the PCs in characterizing machine conditions and to select the most representative PCs to classify machine fault patterns. Then a procedure that uses the low-dimensional PC representations for machine condition monitoring is proposed. The experimental results from an internal-combustion engine sound analysis and an automobile gearbox vibration analysis show that the proposed method is effective for machine condition monitoring.

  1. Use of quadratic components for buckling calculations

    SciTech Connect

    Dohrmann, C.R.; Segalman, D.J.

    1996-12-31

    A buckling calculation procedure based on the method of quadratic components is presented. Recently developed for simulating the motion of rotating flexible structures, the method of quadratic components is shown to be applicable to buckling problems with either conservative or nonconservative loads. For conservative loads, stability follows from the positive definiteness of the system`s stiffness matrix. For nonconservative loads, stability is determined by solving a nonsymmetric eigenvalue problem, which depends on both the stiffness and mass distribution of the system. Buckling calculations presented for a cantilevered beam are shown to compare favorably with classical results. Although the example problem is fairly simple and well-understood, the procedure can be used in conjunction with a general-purpose finite element code for buckling calculations of more complex systems.

  2. Three component vibrational time reversal communication

    SciTech Connect

    Anderson, Brian E.; Ulrich, Timothy J.; Ten Cate, James A.

    2015-01-01

    Time reversal provides an optimal prefilter matched signal to apply to a communication signal before signal transmission. Time reversal allows compensation for wave speed dispersion and can function well in reverberant environments. Time reversal can be used to focus elastic energy to each of the three components of motion independently. A pipe encased in concrete was used to demonstrate the ability to conduct communications of information using three component time reversal. Furthermore, the ability of time reversal to compensate for multi-path distortion (overcoming reverberation) will be demonstrated and the rate of signal communication will be presented. [The U.S. Department of Energy, through the LANL/LDRD Program, is gratefully acknowledged for supporting this work.

  3. Structural reliability analysis of laminated CMC components

    NASA Technical Reports Server (NTRS)

    Duffy, Stephen F.; Palko, Joseph L.; Gyekenyesi, John P.

    1991-01-01

    For laminated ceramic matrix composite (CMC) materials to realize their full potential in aerospace applications, design methods and protocols are a necessity. The time independent failure response of these materials is focussed on and a reliability analysis is presented associated with the initiation of matrix cracking. A public domain computer algorithm is highlighted that was coupled with the laminate analysis of a finite element code and which serves as a design aid to analyze structural components made from laminated CMC materials. Issues relevant to the effect of the size of the component are discussed, and a parameter estimation procedure is presented. The estimation procedure allows three parameters to be calculated from a failure population that has an underlying Weibull distribution.

  4. Thyroid Hormones, Metabolic Syndrome and Its Components.

    PubMed

    Delitala, Alessandro P; Fanciulli, Giuseppe; Pes, Giovanni M; Maioli, Margherita; Delitala, Giuseppe

    2017-03-20

    Metabolic syndrome is a clustering of various metabolic parameters, which included diabetes, low high-density lipoprotein cholesterol, elevated triglycerides, abdominal obesity, and hypertension. It has merged as a worldwide epidemic and a major public health care concern. However, due to the different criteria used for the assessment, the frequency of metabolic syndrome in the general population is variable but it more common in the older people. Metabolic syndrome is closely linked to cardiovascular risk and increases cardiovascular outcomes and all-cause mortality. Recent evidences showed that alterations of the thyroid function could have an impact on the components of the metabolic syndrome, suggesting that thyroid hormones have a variety of effects on energy homeostasis, lipid and glucose metabolism, and blood pressure. In this review we summarize available data on the action of thyroid hormone on the components of metabolic syndrome.

  5. Oxidation of vehicle components by photoproduced holes.

    NASA Technical Reports Server (NTRS)

    Sancier, K. M.; Morrison, S. R.

    1972-01-01

    The oxidation by ZnO holes of vehicle components in thermal control coatings has been examined to develop experimental methods to study such reactions and to identify what components to avoid because of their instability when in the presence of u.v.-produced holes. Two methods were used that show consistent results. An electrochemical technique with a single crystal ZnO anode was used for quantitative comparisons, and electron spin resonance was used to study more practical powder/vehicle systems. Alcohols and dioxane were shown to be readily oxidized by ZnO holes, whereas acetonitrile, neopentane, and ethyl acetate were oxidation resistant. Some resistance to the photooxidation was provided by recombination centers.

  6. Degradation of optical components in space

    NASA Technical Reports Server (NTRS)

    Blue, M. D.

    1993-01-01

    This report concerns two types of optical components: multilayer filters and mirrors, and self-scanned imaging arrays using charge coupled device (CCD) readouts. For the filters and mirrors, contamination produces a strong reduction in transmittance in the ultraviolet spectral region, but has little or no effect in the visible and infrared spectral regions. Soft substrates containing halides are unsatisfactory as windows or substrates. Materials choice for dielectric layers should also reflect such considerations. Best performance is also found for the harder materials. Compaction of the layers and interlayer diffusion causes a blue shift in center wavelength and loss of throughput. For sensors using CCD's, shifts in gate voltage and reductions in transfer efficiency occur. Such effects in CCD's are in accord with expectations of the effects of the radiation dose on the device. Except for optical fiber, degradation of CCD's represents the only ionizing-radiation induced effect on the Long Duration Exposure Facility (LDEF) optical systems components that has been observed.

  7. Translator for Optimizing Fluid-Handling Components

    NASA Technical Reports Server (NTRS)

    Landon, Mark; Perry, Ernest

    2007-01-01

    A software interface has been devised to facilitate optimization of the shapes of valves, elbows, fittings, and other components used to handle fluids under extreme conditions. This software interface translates data files generated by PLOT3D (a NASA grid-based plotting-and- data-display program) and by computational fluid dynamics (CFD) software into a format in which the files can be read by Sculptor, which is a shape-deformation- and-optimization program. Sculptor enables the user to interactively, smoothly, and arbitrarily deform the surfaces and volumes in two- and three-dimensional CFD models. Sculptor also includes design-optimization algorithms that can be used in conjunction with the arbitrary-shape-deformation components to perform automatic shape optimization. In the optimization process, the output of the CFD software is used as feedback while the optimizer strives to satisfy design criteria that could include, for example, improved values of pressure loss, velocity, flow quality, mass flow, etc.

  8. High rate fabrication of compression molded components

    DOEpatents

    Matsen, Marc R.; Negley, Mark A.; Dykstra, William C.; Smith, Glen L.; Miller, Robert J.

    2016-04-19

    A method for fabricating a thermoplastic composite component comprises inductively heating a thermoplastic pre-form with a first induction coil by inducing current to flow in susceptor wires disposed throughout the pre-form, inductively heating smart susceptors in a molding tool to a leveling temperature with a second induction coil by applying a high-strength magnetic field having a magnetic flux that passes through surfaces of the smart susceptors, shaping the magnetic flux that passes through surfaces of the smart susceptors to flow substantially parallel to a molding surface of the smart susceptors, placing the heated pre-form between the heated smart susceptors; and applying molding pressure to the pre-form to form the composite component.

  9. The extinction properties of forest components

    NASA Technical Reports Server (NTRS)

    Karam, M. A.; Fung, A. K.; Blanchard, A. J.; Nance, C. E.

    1988-01-01

    The effect of each forest component on the extinction of electromagnetic waves is investigated by modeling the branches with finite cylinders, deciduous leaves with elliptic disks, and coniferous leaves with needles. The inner field is estimated by the field inside an infinitely long cylinder of similar properties for the branches, and by the Shifrin approximation for the leaves. For each forest component analytic expressions were derived for the extinction cross section via the forward scattering theorem and for ohmic and scattered losses. For branches, the variation of the extinction cross section obtained via the forward scattering theorem is illustrated numerically as a function of the branch radius and the imaginery part of its dielectric constant. It is compared with the measurements from a single branch. For the leaves, the forward scattering theorem gives value for the extinction cross section equal to the ohmic cross section.

  10. The secretion, components, and properties of saliva.

    PubMed

    Carpenter, Guy H

    2013-01-01

    Saliva has one of the most difficult roles to perform in the body. It must facilitate the taste and detection of foods nutritious to the body but also defend the mucosa from infection by the ever-present microbiota present in the mouth. It achieves these roles by having a complex composition and versatile physical properties. The protein and ion components make a solution that is 99% water into a viscoelastic solution capable of many roles, such as acting as a lubricant and an antimicrobial, preventing the dissolution of teeth, aiding digestion, and facilitating taste. This review describes the neural regulation of salivary secretion in terms of fluid, protein, and ion secretion. It then describes some of the components and physical properties of saliva and attempts to relate them to the functions that saliva must perform.

  11. Optical components in harsh space environment

    NASA Astrophysics Data System (ADS)

    Pelizzo, Maria G.; Corso, Alain Jody; Tessarolo, Enrico; Zuppella, P.; Böttger, Roman; Huebner, Rene; Della Corte, Vincenzo; Palumbo, Pasquale; Taglioni, G.; Preti, G.; Foggetta, Luca; Valente, Paolo; Rancoita, Piergiorgio; Martucci, Alessandro; Napolitani, Enrico

    2016-09-01

    Space exploration is linked to the development of increasingly innovative instrumentation, able to withstand the operation environment, rich in ion particles and characterized by high temperatures. Future space missions such as JUICE and SOLAR ORBITER will operate in a very harsh and extreme environment-. Electrons and ions are considered among the causes of potential damage of the optical instrumentation and components. Development of hard coatings capable to preserve their optical properties is pivotal. Different coating materials have been exposed to ion irradiation in particle accelerators. Change in optical performances has been observed in the extreme ultraviolet and visible spectral region and structural properties have been analyzed by different techniques. The knowledge of the damage mechanisms and thresholds allows the selection of more promising candidate materials to realize the optical components for the new frontiers space missions.

  12. Damping characteristics of damaged fiber composite components

    NASA Technical Reports Server (NTRS)

    Eberle, K.

    1986-01-01

    Defects in fiber composite components produce changes with respect to the vibrational characteristics of the material. These changes can be recognized in the form of a frequency shift or an alteration of the damping process. The present investigation is concerned with questions regarding the possibility of a utilization of the changes in suitable defect-detecting inspection procedures. A description is given of a method for measuring the damping characteristics of a specimen. This method provides a spectrum of the damping coefficients of the sample as a basis for a comprehensive evaluation of the damping behavior. The correlation between defects and change in the damping characteristics is demonstrated with the aid of results obtained in measurements involving specimens of carbon-fiber composites and a component consisting of glass-fiber-reinforced plastics.

  13. Three component vibrational time reversal communication

    DOE PAGES

    Anderson, Brian E.; Ulrich, Timothy J.; Ten Cate, James A.

    2015-01-01

    Time reversal provides an optimal prefilter matched signal to apply to a communication signal before signal transmission. Time reversal allows compensation for wave speed dispersion and can function well in reverberant environments. Time reversal can be used to focus elastic energy to each of the three components of motion independently. A pipe encased in concrete was used to demonstrate the ability to conduct communications of information using three component time reversal. Furthermore, the ability of time reversal to compensate for multi-path distortion (overcoming reverberation) will be demonstrated and the rate of signal communication will be presented. [The U.S. Department ofmore » Energy, through the LANL/LDRD Program, is gratefully acknowledged for supporting this work.]« less

  14. System for inspecting large size structural components

    DOEpatents

    Birks, Albert S.; Skorpik, James R.

    1990-01-01

    The present invention relates to a system for inspecting large scale structural components such as concrete walls or the like. The system includes a mobile gamma radiation source and a mobile gamma radiation detector. The source and detector are constructed and arranged for simultaneous movement along parallel paths in alignment with one another on opposite sides of a structural component being inspected. A control system provides signals which coordinate the movements of the source and detector and receives and records the radiation level data developed by the detector as a function of source and detector positions. The radiation level data is then analyzed to identify areas containing defects corresponding to unexpected variations in the radiation levels detected.

  15. Chemical characterization of components in fingerprints

    SciTech Connect

    Jarboe, S.G.; Asano, K.G.; Buchanan, M.V.; Bohanan, A.

    1997-12-31

    Investigations into the chemical composition of fingerprints were initiated after it was observed that the latent fingerprints of children disappear more rapidly from surfaces than those of adults. Initial work included the use of GUMS for the identification of compounds present in fingerprints. The relative concentrations of fatty acids and alkyl esters in children and adults appear to contribute to the higher rate of disappearance of prints from the younger subjects. The presence of alkyl esters is linked to sebaceous excretions originating from the face, which increase markedly after puberty. This work has been expanded to include characterization of other classes of components, including amino acids and triacylglycerols. This research is part of an ongoing project to identify various components of fingerprints and explore possible clinical and forensic applications. Through large sampling pools, trends that can indicate personal characteristics (i.e., gender, age), habits (smoking, drug use), and health-related issues (diabetes) are being investigated.

  16. Integration of Passive Components for Spacecraft Avionics

    NASA Technical Reports Server (NTRS)

    Brandon, E. J.; Wesseling, E.; White, V.; Lieneweg, U.; Mojarradi, M.; Ulrich, R.; Wasef, M.; Mantooth, A.

    2001-01-01

    The NASA roadmap outlining future deep space missions to Europa and other outer planetary destinations calls for continued reductions in the mass and volume of the spacecraft avionics. Spacecraft power electronics, including the power switches and converters, remain difficult to miniaturize due to the need for large numbers of discrete passive components such as resistors, capacitors, inductors and transformers. As part of the System-on-a-chip program at the Center for Integrated Space Microsystems and at the University of Arkansas, we are working to develop integrated or embedded passive components geared specifically for use in power management and distribution (PMAD) in future avionics over the next five to ten years. This will not only enable a scaling down of the power subsystems, but will make possible new architectures such as "distributed" PMAD. Additional information is contained in the original extended abstract.

  17. Thermal spray manual for machinery components

    SciTech Connect

    Travis, R.; Ginther, C.; Herbstritt, M.; Herbstritt, J.

    1995-12-31

    The Thermal Spray Manual For Machinery Components is a National Shipbuilding Research (SP-7) Project. This Manual is being developed by Puget Sound Naval Shipyard with the help of other government thermal spray facilities and SP-7 panel members. The purpose of the manual is to provide marine repair facilities with a ``how to do`` document that will be ``user friendly`` and known to be technically sound through production experience. The manual`s intent is to give marine repair facilities the ability to maximize the thermal spray process as a repair method for machinery components and to give these facilities guidelines on how to become qualified to receive certification that they meet the requirements of Military Standard 1687A.

  18. Profiling refined hydrocarbon fuels using polar components

    USGS Publications Warehouse

    Rostad, C.E.; Hostettler, F.D.

    2007-01-01

    Identification of a fuel released into the environment can be difficult due to biodegradation or weathering. Negative electrospray ionization/mass spectrometry was used to screen for unique polar components in a wide variety of commercial hydrocarbon products and mixtures. These fuels produced unique and relatively simple spectra. When applied to hydrocarbon samples from a large, long-term fuel spill in a relatively cool climate in which the alkane, isoprenoid, and alkylcyclohexane portions had begun to biodegrade or weather, the polar components in these samples had changed little over time. This technique provided rapid fuel identification on hydrocarbons released into the environment, without sample preparation, fractionation, or chromatography. Copyright ?? Taylor & Francis Group, LLC.

  19. FILTER COMPONENT ASSESSMENT--CERAMIC CANDLES--

    SciTech Connect

    M.A. Alvin

    2004-04-23

    Efforts at Siemens Westinghouse Power Corporation (SWPC) have been focused on development of hot gas filter systems as an enabling technology for advanced coal and biomass-based gas turbine power generation applications. SWPC has been actively involved in the development of advanced filter materials and component configuration, has participated in numerous surveillance programs characterizing the material properties and microstructure of field tested filter elements, and has undertaken extended, accelerated filter life testing programs. This report summarizes the results of SWPC's filter component assessment efforts, identifying the performance and stability of porous monolithic, fiber reinforced, and filament wound ceramic hot gas candle filters, potentially for {ge}3 years of viable pressurized fluidized-bed combustion (PFBC) service operating life.

  20. Titin: major myofibrillar components of striated muscle.

    PubMed Central

    Wang, K; McClure, J; Tu, A

    1979-01-01

    Electrophoretic analyses of protein components of striated muscle myofibril purified from various vertebrate and invertebrate species revealed that proteins much larger than myosin heavy chain are present in significant amounts. To define possible roles of these heretofore unidentified proteins, we purified a combination of two uncommonly large proteins, designated as titin, from chicken breast myofibrils. Chemical and immunological studies indicated that titin is distinct from myosin, actin, and filamin. Specific titin anti body crossreacts with similar protein in both skeletal and cardiac myofibrils of many vertebrate and invertebrate species. Immunofluorescent staining of glycerinated chicken breast myofibrils indicated that titin is present in M lines, Z lines, the junctions of A and I bands, and perhaps throughout the entire A bands. Similar staining studies of myofibrils from other species suggest that titinlike proteins may be organized in all myofibrils according to a common architectural plan. We conclude that titin is a structurally conserved myofibrillar component of vertebrate and invertebrate striated muscles. Images PMID:291034

  1. Photopic ERG components in retinitis pigmentosa.

    PubMed

    Anastasi, M; Lauricella, M; Ponte, F

    1992-04-01

    The persistence of a residual flicker electroretinogram 20 Hz response in many cases of retinitis pigmentosa, when the Oscillatory Potentials (OPs) were no longer recordable, led the authors to an investigation by Fourier analysis. The study was carried out in 33 patients affected by different hereditary forms of retinitis pigmentosa revealing recordable 20 Hz flash ERG responses. We applied the Fourier analysis to this ERG response and compared the weight percentage of the first two components to the OP added amplitude. The analysis showed that the 20 Hz flash ERG response contains only the first harmonic in patients with no recordable OPs and both harmonics in patients with recordable OPs. This relationship between OPs and 20 Hz second component, that is possibly related to the activity of inner retina as well as the OPs, can demonstrate an alteration of the inner retina which evolves with distinct electrophysiological features from the ERG photoreceptor impairment.

  2. Principal components analysis of Jupiter VIMS spectra

    USGS Publications Warehouse

    Bellucci, G.; Formisano, V.; D'Aversa, E.; Brown, R.H.; Baines, K.H.; Bibring, J.-P.; Buratti, B.J.; Capaccioni, F.; Cerroni, P.; Clark, R.N.; Coradini, A.; Cruikshank, D.P.; Drossart, P.; Jaumann, R.; Langevin, Y.; Matson, D.L.; McCord, T.B.; Mennella, V.; Nelson, R.M.; Nicholson, P.D.; Sicardy, B.; Sotin, C.; Chamberlain, M.C.; Hansen, G.; Hibbits, K.; Showalter, M.; Filacchione, G.

    2004-01-01

    During Cassini - Jupiter flyby occurred in December 2000, Visual-Infrared mapping spectrometer (VIMS) instrument took several image cubes of Jupiter at different phase angles and distances. We have analysed the spectral images acquired by the VIMS visual channel by means of a principal component analysis technique (PCA). The original data set consists of 96 spectral images in the 0.35-1.05 ??m wavelength range. The product of the analysis are new PC bands, which contain all the spectral variance of the original data. These new components have been used to produce a map of Jupiter made of seven coherent spectral classes. The map confirms previously published work done on the Great Red Spot by using NIMS data. Some other new findings, presently under investigation, are presented. ?? 2004 Published by Elsevier Ltd on behalf of COSPAR.

  3. Selecting reusable components using algebraic specifications

    NASA Technical Reports Server (NTRS)

    Eichmann, David A.

    1992-01-01

    A significant hurdle confronts the software reuser attempting to select candidate components from a software repository - discriminating between those components without resorting to inspection of the implementation(s). We outline a mixed classification/axiomatic approach to this problem based upon our lattice-based faceted classification technique and Guttag and Horning's algebraic specification techniques. This approach selects candidates by natural language-derived classification, by their interfaces, using signatures, and by their behavior, using axioms. We briefly outline our problem domain and related work. Lattice-based faceted classifications are described; the reader is referred to surveys of the extensive literature for algebraic specification techniques. Behavioral support for reuse queries is presented, followed by the conclusions.

  4. Advanced Rotorcraft Transmission (ART) - Component test results

    NASA Astrophysics Data System (ADS)

    Henry, Z. S.

    1992-07-01

    The preliminary design of the ART and some of the component test results are presented. The goals for the future rotorcraft transmissions include a 25-percent weight reduction in comparison with current state-of-the-art transmissions, a 10-dB reduction in the transmitted noise level, and a system reliability of 5,000 hr mean-time-between-removal for the transmission. The ART tests completed to date support the attainment of the three major goals of the program.

  5. IC and Component Selection for Space Systems

    NASA Technical Reports Server (NTRS)

    Label, Kenneth A.; Cohn, Lewis M.

    2007-01-01

    This viewgraph presentation reviews the integrated circuit (IC) and selections of the IC components for space systems. Included in the discussion are a overview of semiconductors and the evolution of integrated circuit. It also reviews the three different viewpoints of the IC selection: technical, programmatic, and risk. From a radiation perspective there are four criteria for selecting ICs for space systems: guaranteed hardness, historical ground-based data, historical flight usage, and unknown assurance.

  6. Experimental system and component performance analysis

    SciTech Connect

    Peterman, K.

    1984-10-01

    A prototype dye laser flow loop was constructed to flow test large power amplifiers in Building 169. The flow loop is designed to operate at supply pressures up to 900 psig and flow rates up to 250 GPM. During the initial startup of the flow loop experimental measurements were made to evaluate component and system performance. Three candidate dye flow loop pumps and three different pulsation dampeners were tested.

  7. WebDB Component Builder - Lessons Learned

    SciTech Connect

    Macedo, C.

    2000-02-15

    Oracle WebDB is the easiest way to produce web enabled lightweight and enterprise-centric applications. This concept from Oracle has tantalized our taste for simplistic web development by using a purely web based tool that lives nowhere else but in the database. The use of online wizards, templates, and query builders, which produces PL/SQL behind the curtains, can be used straight ''out of the box'' by both novice and seasoned developers. The topic of this presentation will introduce lessons learned by developing and deploying applications built using the WebDB Component Builder in conjunction with custom PL/SQL code to empower a hybrid application. There are two kinds of WebDB components: those that display data to end users via reporting, and those that let end users update data in the database via entry forms. The presentation will also discuss various methods within the Component Builder to enhance the applications pushed to the desktop. The demonstrated example is an application entitled HOME (Helping Other's More Effectively) that was built to manage a yearly United Way Campaign effort. Our task was to build an end to end application which could manage approximately 900 non-profit agencies, an average of 4,100 individual contributions, and $1.2 million dollars. Using WebDB, the shell of the application was put together in a matter of a few weeks. However, we did encounter some hurdles that WebDB, in it's stage of infancy (v2.0), could not solve for us directly. Together with custom PL/SQL, WebDB's Component Builder became a powerful tool that enabled us to produce a very flexible hybrid application.

  8. Greenstone belts: Their components and structure

    NASA Technical Reports Server (NTRS)

    Vearncombe, J. R.; Barton, J. M., Jr.; Vanreenen, D. D.; Phillips, G. N.; Wilson, A. H.

    1986-01-01

    Greenstone sucessions are defined as the nongranitoid component of granitoid-greenstone terrain and are linear to irregular in shape and where linear are termed belts. The chemical composition of greenstones is described. Also discussed are the continental environments of greenstone successions. The effects of contact with granitoids, geophysical properties, recumbent folds and late formation structures upon greenstones are examined. Large stratigraphy thicknesses are explained.

  9. Compact Vapor Chamber Cools Critical Components

    NASA Technical Reports Server (NTRS)

    2015-01-01

    Advancements in the production of proton exchange membrane fuel cells have NASA considering their use as a power source for spacecraft and robots in future space missions. With SBIR funding from Glenn Research Center, Lancaster, Pennsylvania-based Thermacore Inc. developed strong, lightweight titanium vapor chambers to keep the fuel cells operating at optimum temperatures. The company is now selling the technology for cooling electronic components.

  10. Nomenclature of SLC Arc beamline components

    SciTech Connect

    Silva, J.; Weng, W.T.

    1986-04-10

    This note defines I and C formal names for beamline components in the Arc as specified in the TRANSPORT decks ARCN FINAL and ARCS FINAL of June 5, 1985. The formal name consists of three fields: the primary name, the zone and the unit number. The general principles and guidelines are explained in Reference 1. The rationale and the final resolutions of the naming conventions for the Arc are explained.

  11. Chemical Blistering: Cellular and Macromolecular Components

    DTIC Science & Technology

    1985-12-15

    animals and appears to be a reaction primarily seen in humans in vhom it may arise as a component cf various cutaneous diseases and as a result of...calls appeared at the surface. Characteristic desmosomal attachment plaques were seen scattered throughout the cell layers. In older lifted cultures...resembling the cornified cells of the normal epidermis had formed. Several epidermal morphological markers were observed, e.g., desmosomes , keratohyalin

  12. Cold Spray for Repair of Magnesium Components

    DTIC Science & Technology

    2011-11-01

    treated to the T-6 condition . Advancing the technology to the point where structural repair of gearboxes and other components is possible should be...increased annual recurring costs associated with health monitoring , record-keeping, etc. On February 28, 2006, the final rule was promulgated at 5 μg/m3...flight testing be conducted under tight monitoring conditions with regular inspection intervals in order to evaluate issues with corrosion. A

  13. Polymer blends with biodegradable components and reinforcements

    NASA Astrophysics Data System (ADS)

    Sartore, Luciana; Di Landro, Luca

    2014-05-01

    Polymeric blends based on ethylene vinyl acetate rubbers filled with high mol. wt. carboxymethyl cellulose were investigated in view of possible employment as biodegradable materials. The effect of vinyl acetate content and of addition of transesterification agent to increase interaction between EVA and cellulosic components was considered. Blends reinforced with cellulose microfibers in different amounts were also characterized in their mechanical, rheological and thermal behavior.

  14. Primordial quark bubbles with leptonic component

    SciTech Connect

    Orsaria, Milva; Duarte, S.B.; Goncalves, H.R.

    2004-12-02

    We introduce the leptonic component to discuss macroscopic bulk properties of primordial bubble quark matter which survived the confinement phase transition in the universe at high temperature. Considering quark matter in equilibrium with the weak interactions, we analyze the boundaries in the {mu} - {mu}e plane for which betha equilibrium and charge neutrality can be valid, being {mu} and {mu}e the chemical potential associated to the baryonic density and the electrons, respectively.

  15. Columbia River Component Data Evaluation Summary Report

    SciTech Connect

    C.S. Cearlock

    2006-08-02

    The purpose of the Columbia River Component Data Compilation and Evaluation task was to compile, review, and evaluate existing information for constituents that may have been released to the Columbia River due to Hanford Site operations. Through this effort an extensive compilation of information pertaining to Hanford Site-related contaminants released to the Columbia River has been completed for almost 965 km of the river.

  16. Cheaper Fabrication Of Tube-Wall Components

    NASA Technical Reports Server (NTRS)

    Bales, Daniel A.; Joyce, James R.

    1993-01-01

    Relatively inexpensive method of forming metal tubes into wall component devised. One initially selects ordinary, imprecisely dimensioned tubes having passed both pressure test and inspections for wall thickness and surface imperfections, and tubes bonded to each other in shorter, simpler procedure. Eliminates need for progressive die forming and attendant inspections after forming steps. Also applicable in fabrication of heat exchangers and other unitary assemblies of tubes.

  17. Dynamic leaching test of personal computer components.

    PubMed

    Li, Yadong; Richardson, Jay B; Niu, Xiaojun; Jackson, Ollie J; Laster, Jeremy D; Walker, Aaron K

    2009-11-15

    A dynamic leaching test (DLT) was developed and used to evaluate the leaching of toxic substances for electronic waste in the environment. The major components in personal computers (PCs) including motherboards, hard disc drives, floppy disc drives, and compact disc drives were tested. The tests lasted for 2 years for motherboards and 1.5 year for the disc drives. The extraction fluids for the standard toxicity characteristic leaching procedure (TCLP) and synthetic precipitation leaching procedure (SPLP) were used as the DLT leaching solutions. A total of 18 elements including Ag, Al, As, Au, Ba, Be, Cd, Cr, Cu, Fe, Ga, Ni, Pd, Pb, Sb, Se, Sn, and Zn were analyzed in the DLT leachates. Only Al, Cu, Fe, Ni, Pb, and Zn were commonly found in the DLT leachates of the PC components. Their leaching levels were much higher in TCLP extraction fluid than in SPLP extraction fluid. The toxic heavy metal Pb was found to continuously leach out of the components over the entire test periods. The cumulative amounts of Pb leached out of the motherboards in TCLP extraction fluid reached 2.0 g per motherboard over the 2-year test period, and that in SPLP extraction fluid were 75-90% less. The leaching rates or levels of Pb were largely affected by the content of galvanized steel in the PC components. The higher was the steel content, the lower the Pb leaching rate would be. The findings suggest that the obsolete PCs disposed of in landfills or discarded in the environment continuously release Pb for years when subjected to landfill leachate or rains.

  18. Mechanical Cutting of Irradiated Reactor Internal Components

    SciTech Connect

    Anderson, M.G.; Fennema, J.A.

    2007-07-01

    This paper discusses the use of mechanical cutting methods to volume reduce and package irradiated reactor internal components. The recent completion of the removal of the Reactor Vessel Internals (RVI) from within the Sacramento Municipal Utility District's (SMUD) Rancho Seco Nuclear Power Plant demonstrates that unlike previous methods used for similar projects, mechanical cutting minimizes exposure to workers, costly water cleanup, and excessive secondary waste generation. (authors)

  19. Dynamic competitive probabilistic principal components analysis.

    PubMed

    López-Rubio, Ezequiel; Ortiz-DE-Lazcano-Lobato, Juan Miguel

    2009-04-01

    We present a new neural model which extends the classical competitive learning (CL) by performing a Probabilistic Principal Components Analysis (PPCA) at each neuron. The model also has the ability to learn the number of basis vectors required to represent the principal directions of each cluster, so it overcomes a drawback of most local PCA models, where the dimensionality of a cluster must be fixed a priori. Experimental results are presented to show the performance of the network with multispectral image data.

  20. Component Verification and Certification in NASA Missions

    NASA Technical Reports Server (NTRS)

    Giannakopoulou, Dimitra; Penix, John; Norvig, Peter (Technical Monitor)

    2001-01-01

    Software development for NASA missions is a particularly challenging task. Missions are extremely ambitious scientifically, have very strict time frames, and must be accomplished with a maximum degree of reliability. Verification technologies must therefore be pushed far beyond their current capabilities. Moreover, reuse and adaptation of software architectures and components must be incorporated in software development within and across missions. This paper discusses NASA applications that we are currently investigating from these perspectives.

  1. Real-Time Principal-Component Analysis

    NASA Technical Reports Server (NTRS)

    Duong, Vu; Duong, Tuan

    2005-01-01

    A recently written computer program implements dominant-element-based gradient descent and dynamic initial learning rate (DOGEDYN), which was described in Method of Real-Time Principal-Component Analysis (NPO-40034) NASA Tech Briefs, Vol. 29, No. 1 (January 2005), page 59. To recapitulate: DOGEDYN is a method of sequential principal-component analysis (PCA) suitable for such applications as data compression and extraction of features from sets of data. In DOGEDYN, input data are represented as a sequence of vectors acquired at sampling times. The learning algorithm in DOGEDYN involves sequential extraction of principal vectors by means of a gradient descent in which only the dominant element is used at each iteration. Each iteration includes updating of elements of a weight matrix by amounts proportional to a dynamic initial learning rate chosen to increase the rate of convergence by compensating for the energy lost through the previous extraction of principal components. In comparison with a prior method of gradient-descent-based sequential PCA, DOGEDYN involves less computation and offers a greater rate of learning convergence. The sequential DOGEDYN computations require less memory than would parallel computations for the same purpose. The DOGEDYN software can be executed on a personal computer.

  2. Cryogenic Applications of Commercial Electronic Components

    NASA Technical Reports Server (NTRS)

    Buchanan, Ernest D.; Benford, Dominic J.; Forgione, Joshua B.; Moseley, S. Harvey; Wollack, Edward J.

    2012-01-01

    We have developed a range of techniques useful for constructing analog and digital circuits for operation in a liquid Helium environment (4.2K), using commercially available low power components. The challenges encountered in designing cryogenic electronics include finding components that can function usefully in the cold and possess low enough power dissipation so as not to heat the systems they are designed to measure. From design, test, and integration perspectives it is useful for components to operate similarly at room and cryogenic temperatures; however this is not a necessity. Some of the circuits presented here have been used successfully in the MUSTANG and in the GISMO camera to build a complete digital to analog multiplexer (which will be referred to as the Cryogenic Address Driver board). Many of the circuit elements described are of a more general nature rather than specific to the Cryogenic Address Driver board, and were studied as a part of a more comprehensive approach to addressing a larger set of cryogenic electronic needs.

  3. Multilevel sparse functional principal component analysis.

    PubMed

    Di, Chongzhi; Crainiceanu, Ciprian M; Jank, Wolfgang S

    2014-01-29

    We consider analysis of sparsely sampled multilevel functional data, where the basic observational unit is a function and data have a natural hierarchy of basic units. An example is when functions are recorded at multiple visits for each subject. Multilevel functional principal component analysis (MFPCA; Di et al. 2009) was proposed for such data when functions are densely recorded. Here we consider the case when functions are sparsely sampled and may contain only a few observations per function. We exploit the multilevel structure of covariance operators and achieve data reduction by principal component decompositions at both between and within subject levels. We address inherent methodological differences in the sparse sampling context to: 1) estimate the covariance operators; 2) estimate the functional principal component scores; 3) predict the underlying curves. Through simulations the proposed method is able to discover dominating modes of variations and reconstruct underlying curves well even in sparse settings. Our approach is illustrated by two applications, the Sleep Heart Health Study and eBay auctions.

  4. Ab initio two-component Ehrenfest dynamics

    SciTech Connect

    Ding, Feizhi; Goings, Joshua J.; Liu, Hongbin; Lingerfelt, David B.; Li, Xiaosong

    2015-09-21

    We present an ab initio two-component Ehrenfest-based mixed quantum/classical molecular dynamics method to describe the effect of nuclear motion on the electron spin dynamics (and vice versa) in molecular systems. The two-component time-dependent non-collinear density functional theory is used for the propagation of spin-polarized electrons while the nuclei are treated classically. We use a three-time-step algorithm for the numerical integration of the coupled equations of motion, namely, the velocity Verlet for nuclear motion, the nuclear-position-dependent midpoint Fock update, and the modified midpoint and unitary transformation method for electronic propagation. As a test case, the method is applied to the dissociation of H{sub 2} and O{sub 2}. In contrast to conventional Ehrenfest dynamics, this two-component approach provides a first principles description of the dynamics of non-collinear (e.g., spin-frustrated) magnetic materials, as well as the proper description of spin-state crossover, spin-rotation, and spin-flip dynamics by relaxing the constraint on spin configuration. This method also holds potential for applications to spin transport in molecular or even nanoscale magnetic devices.

  5. Multimode siloxane polymer components for optical interconnects

    NASA Astrophysics Data System (ADS)

    Bamiedakis, Nikolaos; Beals, Joseph, IV; Penty, Richard V.; White, Ian H.; DeGroot, Jon v., Jr.; Clapp, Terry V.; De Shazer, David

    2009-02-01

    This paper presents an overview of multimode waveguides and waveguide components formed from siloxane polymer materials which are suitable for use in optical interconnection applications. The components can be cost-effectively integrated onto conventional PCBs and offer increased functionality in optical transmission. The multimode waveguides exhibit low loss (0.04 dB/cm at 850 nm) and low crosstalk (< -30 dB) performance, large alignment tolerances and negligible mode mixing for short waveguide lengths. Error-free data transmission at 10 Gb/s over 1.4 m long waveguides has been successfully demonstrated. Waveguide crossings exhibit very low excess losses, below 0.01 dB/crossing, and excellent crosstalk performance. Low loss is obtained for waveguide bends with radii of curvature larger than 8 mm and 6 mm for 90° and S-shaped bends respectively. High-uniformity splitting is achieved with multimode Y-splitters even in the presence of input misalignments. Y-combiners are shown to benefit from the multimode nature of the waveguides allowing low loss combining (4 dB for an 8×1 device). A large range of power splitting ratios between 30% and 75% is achieved with multimode coupler devices. Examples of system applications benefiting from the use of these components are briefly presented including a terabit capacity optical backplane, a radio-over-fibre multicasting system and a SCM passive optical network.

  6. Lignin: Characterization of a Multifaceted Crop Component

    PubMed Central

    2013-01-01

    Lignin is a plant component with important implications for various agricultural disciplines. It confers rigidity to cell walls, and is therefore associated with tolerance to abiotic and biotic stresses and the mechanical stability of plants. In animal nutrition, lignin is considered an antinutritive component of forages as it cannot be readily fermented by rumen microbes. In terms of energy yield from biomass, the role of lignin depends on the conversion process. It contains more gross energy than other cell wall components and therefore confers enhanced heat value in thermochemical processes such as direct combustion. Conversely, it negatively affects biological energy conversion processes such as bioethanol or biogas production, as it inhibits microbial fermentation of the cell wall. Lignin from crop residues plays an important role in the soil organic carbon cycling, as it constitutes a recalcitrant carbon pool affecting nutrient mineralization and carbon sequestration. Due to the significance of lignin in several agricultural disciplines, the modification of lignin content and composition by breeding is becoming increasingly important. Both mapping of quantitative trait loci and transgenic approaches have been adopted to modify lignin in crops. However, breeding goals must be defined considering the conflicting role of lignin in different agricultural disciplines. PMID:24348159

  7. Principle component analysis for radiotracer signal separation.

    PubMed

    Kasban, H; Arafa, H; Elaraby, S M S

    2016-06-01

    Radiotracers can be used in several industrial applications by injecting the radiotracer into the industrial system and monitoring the radiation using radiation detectors for obtaining signals. These signals are analyzed to obtain indications about what is happening within the system or to determine the problems that may be present in the system. For multi-phase system analysis, more than one radiotracer is used and the result is a mixture of radiotracers signals. The problem is in such cases is how to separate these signals from each other. The paper presents a proposed method based on Principle Component Analysis (PCA) for separating mixed two radiotracer signals from each other. Two different radiotracers (Technetium-99m (Tc(99m)) and Barium-137m (Ba(137m))) were injected into a physical model for simulation of chemical reactor (PMSCR-MK2) for obtaining the radiotracer signals using radiation detectors and Data Acquisition System (DAS). The radiotracer signals are mixed and signal processing steps are performed include background correction and signal de-noising, then applying the signal separation algorithms. Three separation algorithms have been carried out; time domain based separation algorithm, Independent Component Analysis (ICA) based separation algorithm, and Principal Components Analysis (PCA) based separation algorithm. The results proved the superiority of the PCA based separation algorithm to the other based separation algorithm, and PCA based separation algorithm and the signal processing steps gives a considerable improvement of the separation process.

  8. Vibration detection of component health and operability

    NASA Technical Reports Server (NTRS)

    Baird, B. C.

    1975-01-01

    In order to prevent catastrophic failure and eliminate unnecessary periodic maintenance in the shuttle orbiter program environmental control system components, some means of detecting incipient failure in these components is required. The utilization was investigated of vibrational/acoustic phenomena as one of the principal physical parameters on which to base the design of this instrumentation. Baseline vibration/acoustic data was collected from three aircraft type fans and two aircraft type pumps over a frequency range from a few hertz to greater than 3000 kHz. The baseline data included spectrum analysis of the baseband vibration signal, spectrum analysis of the detected high frequency bandpass acoustic signal, and amplitude distribution of the high frequency bandpass acoustic signal. A total of eight bearing defects and two unbalancings was introduced into the five test items. All defects were detected by at least one of a set of vibration/acoustic parameters with a margin of at least 2:1 over the worst case baseline. The design of a portable instrument using this set of vibration/acoustic parameters for detecting incipient failures in environmental control system components is described.

  9. Data Transmission System For A Downhole Component

    DOEpatents

    Hall, David R.; Hall, Jr., H. Tracy; Pixton, David; Dahlgren, Scott; Sneddon, Cameron; Fox, Joe; Briscoe, Michael

    2005-01-18

    The invention is a system for transmitting data through a string of downhole components. In accordance with one aspect of the invention, the system includes a plurality of downhole components, such as sections of pipe in a drill string. Each component has a first and second end, with a first communication element located at the first end and a second communication element located at the second end. Each communication element includes a first contact and a second contact. The system also includes a coaxial cable running between the first and second communication elements, the coaxial cable having a conductive tube and a conductive core within it. The system also includes a first and second connector for connecting the first and second communication elements respectively to the coaxial cable. Each connector includes a conductive sleeve, lying concentrically within the conductive tube, which fits around and makes electrical contact with the conductive core. The conductive sleeve is electrically isolated from the conductive tube. The conductive sleeve of the first connector is in electrical contact with the first contact of the first communication element, the conductive sleeve of the second connector is in electrical contact with the first contact of the second communication element, and the conductive tube is in electrical contact with both the second contact of the first communication element and the second contact of the second communication element.

  10. Data transmission system for a downhole component

    DOEpatents

    Hall, David R.; Hall, Jr., Tracy H.; Pixton, David S.; Dahlgren, Scott Steven; Fox, Joe; Sneddon, Cameron; Briscoe, Michael A.

    2006-05-09

    The invention is a system for transmitting data through a string of downhole components. In accordance with one aspect of the invention, the system includes a plurality of downhole components, such as sections of pipe in a drill string. Each component has a first and second end, with a first communication element located at the first end and a second communication element located at the second end. Each communication element includes a first contact and a second contact. The system also includes a coaxial cable running between the first and second communication elements, the coaxial cable having a conductive tube and a conductive core within it. The system also includes a first and second connector for connecting the first and second communication elements respectively to the coaxial cable. Each connector includes a conductive sleeve, lying concentrically within the conductive tube, which fits around and makes electrical contact with the conductive core. The conductive sleeve is electrically isolated from the conductive tube. The conductive sleeve of the first connector is in electrical contact with the first contact of the first communication element, the conductive sleeve of the second connector is in electrical contact with the first contact of the second communication element, and the conductive tube is in electrical contact with both the second contact of the first communication element and the second contact of the second communication element.

  11. Cryogenic applications of commercial electronic components

    NASA Astrophysics Data System (ADS)

    Buchanan, Ernest D.; Benford, Dominic J.; Forgione, Joshua B.; Harvey Moseley, S.; Wollack, Edward J.

    2012-10-01

    We have developed a range of techniques useful for constructing analog and digital circuits for operation in a liquid Helium environment (4.2 K), using commercially available low power components. The challenges encountered in designing cryogenic electronics include finding components that can function usefully in the cold and possess low enough power dissipation so as not to heat the systems they are designed to measure. From design, test, and integration perspectives it is useful for components to operate similarly at room and cryogenic temperatures; however this is not a necessity. Some of the circuits presented here have been used successfully in the MUSTANG [1] and in the GISMO [2] camera to build a complete digital to analog multiplexer (which will be referred to as the Cryogenic Address Driver board). Many of the circuit elements described are of a more general nature rather than specific to the Cryogenic Address Driver board, and were studied as a part of a more comprehensive approach to addressing a larger set of cryogenic electronic needs.

  12. Component Labeling Algorithm For Video Rate Processing

    NASA Astrophysics Data System (ADS)

    Gotoh, Toshiyuki; Ohta, Yoshiyuki; Yoshida, Masumi; Shirai, Yoshio

    1987-10-01

    In this paper, we propose a raster scanning algorithm for component labeling, which enables processing under pipeline architecture. In the raster scanning algorithm, labels are provisionally assigned to each pixel of components and, at the same time, the connectivities of labels are detected at first scan. Those labels are classified into groups based on the connectivities. Finally provisional labels are updated using the result of classification and a unique label is assigned to each pixel of components. However, in the conventional algorithm, the classification process needs a vast number of operations. This prevents realizing pipeline processing. We have developed a method of preprocessing to reduce the number of provisional labels, which limits the number of label connectivities. We have also developed a new classification method whose operation is proportionate to only the number of label connectivities itself. We have made experiments with computer simulation to verify this algorithm. The experimental results show that we can process 512 x 512 x 8 bit images at video rate(1/30 sec. per 1 image) when this algorithm is implemented on hardware.

  13. Bi-Component Droplet Combustion Experiment Designed

    NASA Technical Reports Server (NTRS)

    Dietrich, Daniel L.

    2002-01-01

    The combustion of liquid fuels is a major source of energy in the world today, and the majority of these fuels are burned in the form of a spray. The research at the NASA Glenn Research Center in droplet combustion has the overall goal of providing a better understanding of spray combustion by studying the smallest element in a spray, the single droplet. The Bi-Component Droplet Combustion Experiment (BCDCE) extends the work at Glenn from pure, or single-component, fuels to an idealized liquid fuel composed of two completely miscible components. The project is a collaborative effort between Glenn and Prof. B.D. Shaw of the University of California, Davis. The BCDCE project is planned to fly onboard the International Space Station in the Multi-User Droplet Combustion Apparatus. The unique feature of this experiment is that it will be the first droplet combustion experiment to perform a detailed characterization of the flow inside a liquid fuel droplet. The experiment will use a relatively new technique called Digital Particle Imaging Velocimetry (DPIV) to characterize the liquid flow. In this technique, very small (approx. 5-mm diameter) particles are dispersed throughout a liquid droplet. These particles are illuminated by a thin laser sheet. Images of the particle motion are recorded on a computer, which then tracks the motion of the particles to determine the flow characteristics.

  14. Superplastic forming of stainless steel automotive components

    SciTech Connect

    Bridges, B.; Elmer, J.; Carol, L.

    1997-02-06

    Exhaust emission standards are governmentally controlled standards, which are increasingly stringent, forcing alternate strategies to meet these standards. One approach to improve the efficiency of the exhaust emission equipment is to decrease the time required to get the catalytic converter to optimum operating temperature. To accomplish this, automotive manufacturers are using double wall stainless steel exhaust manifolds to reduce heat loss of the exhaust gases to the converter. The current method to manufacture double wall stainless steel exhaust components is to use a low-cost alloy with good forming properties and extensively form, cut, assemble, and weld the pieces. Superplastic forming (SPF) technology along with alloy improvements has potential at making this process more cost effective. Lockheed Martin Energy Systems (LMES), Lawrence Livermore National Laboratory (LLNL) and USCAR Low Emission Partnership (LEP) worked under a Cooperative Research And Development Agreement (CRADA) to evaluate material properties, SPF behavior, and welding behavior of duplex stainless steel alloy for automotive component manufacturing. Battelle Pacific Northwest National Laboratory (PNNL) has a separate CRADA with the LEP to use SPF technology to manufacture a double wall stainless steel exhaust component. As a team these CRADAs developed and demonstrated a technical plan to accomplish making double wall stainless steel exhaust manifolds.

  15. Component engineering for an implantable system.

    PubMed

    Wang, Qingtian; Yambe, Tomoyuki; Shiraishi, Yasuyuki; Esashi, Masayoshi; Haga, Youichi; Yoshizawa, Makoto; Sato, Fumihiro; Matsuki, Hidetoshi; Imachi, Kou; Abe, Yusuke; Sasada, Hiroshi; Nitta, Shin-Ichi

    2004-10-01

    Component engineering is important for the development of implantable-type rotary blood pumps (RP). The authors are conducting elementary development of an implantable artificial heart. A sensor system detects information in the living body. An automatic control system performs the drive control. Energy is provided by a transcutaneous energy transmission system (TETS). Various artificial hearts are being created. Miniaturization resulting from an increase in operating frequency is planned. A vibrating flow pump (VFP) has a reduced size of pumping chamber because of the high-speed reciprocating movement. Undulation pump ventricular assist devices (UPVAD) are small, lightweight rotary pumps. VFPs are useful in the medical treatment of multiple organ failure (MOF). UPVADs are planned to be permanent-use RPs. The purposes of these two artificial hearts differ, although they have a common component. The authors are developing TETS by using amorphous fibers, making efficient power transmission possible. Control information input from a micro or nano sensor is realized. A control algorithm has been developed and baroreflex control has been successful. Artificial heart development, fully exploiting component engineering, continues.

  16. Mechanical cutting of irradiated reactor internal components

    SciTech Connect

    Anderson, Michael G.

    2008-01-15

    Mechanical cutting methods to volume reduce and package reactor internal components are now a viable solution for stakeholders challenged with the retirement of first generation nuclear facilities. The recent completion of the removal of the Reactor Vessel Internals (RVI) from within the Sacramento Municipal Utility District's (SMUD) Rancho Seco Nuclear Power Plant demonstrates that unlike previous methods, inclusive of plasma arc and abrasive water-jet cutting, mechanical cutting minimizes exposure to workers, costly water cleanup, and excessive secondary waste generation. Reactor internal components were segmented, packaged, and removed from the reactor building for shipment or storage, allowing the reactor cavity to be drained and follow-on reactor segmentation activities to proceed in the dry state. Area exposure rates at the work positions during the segmentation process were generally 1 mR per hr. Radiological exposure documented for the underwater segmentation processes totaled 13 person rem. The reactor internals weighing 343,000 pounds were segmented into over 200 pieces for maximum shipping package efficiency and produced 5,600 lb of stainless steel chips and shavings which were packaged in void spaces of existing disposal containers, therefore creating no additional disposal volume. Because no secondary waste was driven into suspension in the reactor cavity water, the water was free released after one pass through a charcoal bed and ion exchange filter system. Mechanical cutting techniques are capable of underwater segmentation of highly radioactive components on a large scale. This method minimized radiological exposure and costly water cleanup while creating no secondary waste.

  17. The diffuse component of erythemal ultraviolet radiation.

    PubMed

    Silva, Abel A

    2015-11-01

    The diffuse (Dif) component of ultraviolet radiation (UVR) plays an important role in the daily exposure of humans to solar radiation. This study proposes a semi-empirical method to obtain the Dif component of the erythemal dose rate, or the erythemally weighted irradiance, (EDRDif) calculated from synchronized measurements of the Dif component of UVR (UVDif) and the global (G) irradiances of both UVR (UVG) and the erythemal dose rate (EDRG). Since the study was conducted in the tropics, results involve a wide range of solar zenith angles to which EDRDif is seasonally dependent. Clouds are the main atmospheric agent affecting Dif radiation. The ratio between Dif and G (Dif/G) showed a quadratic dependence on cloud cover with a coefficient of determination r(2) = 0.79. The maxima of EDRDif were mainly above the moderate range (>137.5 mW m(-2)) of the UV-Index and reached the extreme range (>262.5 mW m(-2)) for the spring-summer period. The fraction of the global daily erythemal dose (daily EDG) corresponding to Dif radiation (daily EDDif) ranged from 936 J m(-2) to 5053 J m(-2) and averaged 2673 J m(-2). Daily EDDif corresponded to at least 48% of daily EDG for a practically cloudless sky. Therefore, Dif radiation is a real threat. Lighter skin people (types I and II) can get sunburnt in a couple of minutes under such an incidence of radiation. Moreover, accumulative harm can affect all skin types.

  18. The solvent component of macromolecular crystals

    PubMed Central

    Weichenberger, Christian X.; Afonine, Pavel V.; Kantardjieff, Katherine; Rupp, Bernhard

    2015-01-01

    The mother liquor from which a biomolecular crystal is grown will contain water, buffer molecules, native ligands and cofactors, crystallization precipitants and additives, various metal ions, and often small-molecule ligands or inhibitors. On average, about half the volume of a biomolecular crystal consists of this mother liquor, whose components form the disordered bulk solvent. Its scattering contributions can be exploited in initial phasing and must be included in crystal structure refinement as a bulk-solvent model. Concomitantly, distinct electron density originating from ordered solvent components must be correctly identified and represented as part of the atomic crystal structure model. Herein, are reviewed (i) probabilistic bulk-solvent content estimates, (ii) the use of bulk-solvent density modification in phase improvement, (iii) bulk-solvent models and refinement of bulk-solvent contributions and (iv) modelling and validation of ordered solvent constituents. A brief summary is provided of current tools for bulk-solvent analysis and refinement, as well as of modelling, refinement and analysis of ordered solvent components, including small-molecule ligands. PMID:25945568

  19. Methods for integrating a functional component into a microfluidic device

    DOEpatents

    Simmons, Blake; Domeier, Linda; Woo, Noble; Shepodd, Timothy; Renzi, Ronald F.

    2014-08-19

    Injection molding is used to form microfluidic devices with integrated functional components. One or more functional components are placed in a mold cavity, which is then closed. Molten thermoplastic resin is injected into the mold and then cooled, thereby forming a solid substrate including the functional component(s). The solid substrate including the functional component(s) is then bonded to a second substrate, which may include microchannels or other features.

  20. Effective one-component description of two-component Bose-Einstein condensate dynamics

    SciTech Connect

    Dutton, Zachary; Clark, Charles W.

    2005-06-15

    We investigate dynamics in two-component Bose-Einstein condensates in the context of coupled Gross-Pitaevskii equations and derive results for the evolution of the total density fluctuations. Using these results, we show how, in many cases of interest, the dynamics can be accurately described with an effective one-component Gross-Pitaevskii equation for one of the components, with the trap and interaction coefficients determined by the relative differences in the scattering lengths. We discuss the model in various regimes, where it predicts breathing excitations, and the formation of vector solitons. An effective nonlinear evolution is predicted for some cases of current experimental interest. We then apply the model to construct quasistationary states of two-component condensates.