Trilinos I/O Support (Trios)

DOE PAGES

Oldfield, Ron A.; Sjaardema, Gregory D.; Lofstead II, Gerald F.; ...

2012-01-01

Trilinos I/O Support (Trios) is a new capability area in Trilinos that serves two important roles: (1) it provides and supports I/O libraries used by in-production scientific codes; (2) it provides a research vehicle for the evaluation and distribution of new techniques to improve I/O on advanced platforms. This paper provides a brief overview of the production-grade I/O libraries in Trios as well as some of the ongoing research efforts that contribute to the experimental libraries in Trios.

Cybersecurity in Artificial Pancreas Experiments.

PubMed

O'Keeffe, Derek T; Maraka, Spyridoula; Basu, Ananda; Keith-Hynes, Patrick; Kudva, Yogish C

2015-09-01

Medical devices have transformed modern health care, and ongoing experimental medical technology trials (such as the artificial pancreas) have the potential to significantly improve the treatment of several chronic conditions, including diabetes mellitus. However, we suggest that, to date, the essential concept of cybersecurity has not been adequately addressed in this field. This article discusses several key issues of cybersecurity in medical devices and proposes some solutions. In addition, it outlines the current requirements and efforts of regulatory agencies to increase awareness of this topic and to improve cybersecurity.

Thermodynamic analysis and subscale modeling of space-based orbit transfer vehicle cryogenic propellant resupply

NASA Technical Reports Server (NTRS)

Defelice, David M.; Aydelott, John C.

1987-01-01

The resupply of the cryogenic propellants is an enabling technology for spacebased orbit transfer vehicles. As part of the NASA Lewis ongoing efforts in microgravity fluid management, thermodynamic analysis and subscale modeling techniques were developed to support an on-orbit test bed for cryogenic fluid management technologies. Analytical results have shown that subscale experimental modeling of liquid resupply can be used to validate analytical models when the appropriate target temperature is selected to relate the model to its prototype system. Further analyses were used to develop a thermodynamic model of the tank chilldown process which is required prior to the no-vent fill operation. These efforts were incorporated into two FORTRAN programs which were used to present preliminary analyticl results.

Exemplar for simulation challenges: Large-deformation micromechanics of Sylgard 184/glass microballoon syntactic foams.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, Judith Alice; Long, Kevin Nicholas

2018-05-01

Sylgard® 184/Glass Microballoon (GMB) potting material is currently used in many NW systems. Analysts need a macroscale constitutive model that can predict material behavior under complex loading and damage evolution. To address this need, ongoing modeling and experimental efforts have focused on study of damage evolution in these materials. Micromechanical finite element simulations that resolve individual GMB and matrix components promote discovery and better understanding of the material behavior. With these simulations, we can study the role of the GMB volume fraction, time-dependent damage, behavior under confined vs. unconfined compression, and the effects of partial damage. These simulations are challengingmore » and push the boundaries of capability even with the high performance computing tools available at Sandia. We summarize the major challenges and the current state of this modeling effort, as an exemplar of micromechanical modeling needs that can motivate advances in future computing efforts.« less

MO-FG-BRC-02: Low-Z Switching Linear Accelerator Targets: New Options for Image Guidance and Dose Enhancement in Radiotherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robar, J.

2016-06-15

Experimental research in medical physics has expanded the limits of our knowledge and provided novel imaging and therapy technologies for patients around the world. However, experimental efforts are challenging due to constraints in funding, space, time and other forms of institutional support. In this joint ESTRO-AAPM symposium, four exciting experimental projects from four different countries are highlighted. Each project is focused on a different aspect of radiation therapy. From the USA, we will hear about a new linear accelerator concept for more compact and efficient therapy devices. From Canada, we will learn about novel linear accelerator target design and themore » implications for imaging and therapy. From France, we will discover a mature translational effort to incorporate theranostic nanoparticles in MR-guided radiation therapy. From Germany, we will find out about a novel in-treatment imaging modality for particle therapy. These examples of high impact, experimental medical physics research are representative of the diversity of such efforts that are on-going around the globe. J. Robar, Research is supported through collaboration with Varian Medical Systems and Brainlab AGD. Westerly, This work is supported by the Department of Radiation Oncology at the University of Colorado School of Medicine. COI: NONEK. Parodi, Part of the presented work is supported by the DFG (German Research Foundation) Cluster of Excellence MAP (Munich-Centre for Advanced Photonics) and has been carried out in collaboration with IBA.« less

MO-FG-BRC-01: MR-Guided Radiation Therapy with Gadolinium Nanoparticles: From Chalkboard to First Clinical Trials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sancey, L.

2016-06-15

Experimental research in medical physics has expanded the limits of our knowledge and provided novel imaging and therapy technologies for patients around the world. However, experimental efforts are challenging due to constraints in funding, space, time and other forms of institutional support. In this joint ESTRO-AAPM symposium, four exciting experimental projects from four different countries are highlighted. Each project is focused on a different aspect of radiation therapy. From the USA, we will hear about a new linear accelerator concept for more compact and efficient therapy devices. From Canada, we will learn about novel linear accelerator target design and themore » implications for imaging and therapy. From France, we will discover a mature translational effort to incorporate theranostic nanoparticles in MR-guided radiation therapy. From Germany, we will find out about a novel in-treatment imaging modality for particle therapy. These examples of high impact, experimental medical physics research are representative of the diversity of such efforts that are on-going around the globe. J. Robar, Research is supported through collaboration with Varian Medical Systems and Brainlab AGD. Westerly, This work is supported by the Department of Radiation Oncology at the University of Colorado School of Medicine. COI: NONEK. Parodi, Part of the presented work is supported by the DFG (German Research Foundation) Cluster of Excellence MAP (Munich-Centre for Advanced Photonics) and has been carried out in collaboration with IBA.« less

Start-Up and Ongoing Practice Expenses of Behavioral Health and Primary Care Integration Interventions in the Advancing Care Together (ACT) Program.

PubMed

Wallace, Neal T; Cohen, Deborah J; Gunn, Rose; Beck, Arne; Melek, Steve; Bechtold, Donald; Green, Larry A

2015-01-01

Provide credible estimates of the start-up and ongoing effort and incremental practice expenses for the Advancing Care Together (ACT) behavioral health and primary care integration interventions. Expenditure data were collected from 10 practice intervention sites using an instrument with a standardized general format that could accommodate the unique elements of each intervention. Average start-up effort expenses were $44,076 and monthly ongoing effort expenses per patient were $40.39. Incremental expenses averaged $20,788 for start-up and $4.58 per patient for monthly ongoing activities. Variations in expenditures across practices reflect the differences in intervention specifics and organizational settings. Differences in effort to incremental expenditures reflect the extensive use of existing resources in implementing the interventions. ACT program incremental expenses suggest that widespread adoption would likely have a relatively modest effect on overall health systems expenditures. Practice effort expenses are not trivial and may pose barriers to adoption. Payers and purchasers interested in attaining widespread adoption of integrated care must consider external support to practices that accounts for both incremental and effort expense levels. Existing knowledge transfer mechanisms should be employed to minimize developmental start-up expenses and payment reform focused toward value-based, Triple Aim-oriented reimbursement and purchasing mechanisms are likely needed. © Copyright 2015 by the American Board of Family Medicine.

Nuclear Cryogenic Propulsion Stage (NCPS) Fuel Element Testing in the Nuclear Thermal Rocket Element Environmental Simulator (NTREES)

NASA Technical Reports Server (NTRS)

Emrich, William J., Jr.

2017-01-01

To support the on-going nuclear thermal propulsion effort, a state-of-the-art non nuclear experimental test setup has been constructed to evaluate the performance characteristics of candidate fuel element materials and geometries in representative environments. The facility to perform this testing is referred to as the Nuclear Thermal Rocket Element Environment Simulator (NTREES). Last year NTREES was successfully used to satisfy a testing milestone for the Nuclear Cryogenic Propulsion Stage (NCPS) project and met or exceeded all required objectives.

Low-cost Large Aperture Telescopes for Optical Communications

NASA Technical Reports Server (NTRS)

Hemmati, Hamid

2006-01-01

Low-cost, large-aperture optical receivers are required to form an affordable optical ground receiver network for laser communications. Among the ground receiver station's multiple subsystems, here, we only discuss the ongoing research activities aimed at reducing the cost of the large-size optics on the receiver. Experimental results of two different approaches for fabricating low-cost mirrors of wavefront quality on the order of 100-200X the diffraction limit are described. Laboratory-level effort are underway to improve the surface figure to better than 20X the diffraction limit.

Cybersecurity in Artificial Pancreas Experiments

PubMed Central

O'Keeffe, Derek T.; Maraka, Spyridoula; Basu, Ananda; Keith-Hynes, Patrick

2015-01-01

Abstract Medical devices have transformed modern health care, and ongoing experimental medical technology trials (such as the artificial pancreas) have the potential to significantly improve the treatment of several chronic conditions, including diabetes mellitus. However, we suggest that, to date, the essential concept of cybersecurity has not been adequately addressed in this field. This article discusses several key issues of cybersecurity in medical devices and proposes some solutions. In addition, it outlines the current requirements and efforts of regulatory agencies to increase awareness of this topic and to improve cybersecurity. PMID:25923544

Merging the Machines of Modern Science

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wolf, Laura; Collins, Jim

Two recent projects have harnessed supercomputing resources at the US Department of Energy’s Argonne National Laboratory in a novel way to support major fusion science and particle collider experiments. Using leadership computing resources, one team ran fine-grid analysis of real-time data to make near-real-time adjustments to an ongoing experiment, while a second team is working to integrate Argonne’s supercomputers into the Large Hadron Collider/ATLAS workflow. Together these efforts represent a new paradigm of the high-performance computing center as a partner in experimental science.

Developing Wide-Field Spatio-Spectral Interferometry for Far-Infrared Space Applications

NASA Technical Reports Server (NTRS)

Leisawitz, David; Bolcar, Matthew R.; Lyon, Richard G.; Maher, Stephen F.; Memarsadeghi, Nargess; Rinehart, Stephen A.; Sinukoff, Evan J.

2012-01-01

Interferometry is an affordable way to bring the benefits of high resolution to space far-IR astrophysics. We summarize an ongoing effort to develop and learn the practical limitations of an interferometric technique that will enable the acquisition of high-resolution far-IR integral field spectroscopic data with a single instrument in a future space-based interferometer. This technique was central to the Space Infrared Interferometric Telescope (SPIRIT) and Submillimeter Probe of the Evolution of Cosmic Structure (SPECS) space mission design concepts, and it will first be used on the Balloon Experimental Twin Telescope for Infrared Interferometry (BETTII). Our experimental approach combines data from a laboratory optical interferometer (the Wide-field Imaging Interferometry Testbed, WIIT), computational optical system modeling, and spatio-spectral synthesis algorithm development. We summarize recent experimental results and future plans.

On the Relationship Between Effort Toward an Ongoing Task and Cue Detection in Event-Based Prospective Memory

ERIC Educational Resources Information Center

Marsh, Richard L.; Hicks, Jason L.; Cook, Gabriel I.

2005-01-01

In recent theories of event-based prospective memory, researchers have debated what degree of resources are necessary to identify a cue as related to a previously established intention. In order to simulate natural variations in attention, the authors manipulated effort toward an ongoing cognitive task in which intention-related cues were embedded…

Petroselinum crispum extract attenuates hepatic steatosis in rats fed with fructose enriched diet.

PubMed

Nair, V Yuneesha; Balakrishanan, N; Antony Santiago, J Victor

2015-01-01

Non alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and ongoing research efforts are focused on understanding the underlying pathophysiology of hepatic steatosis with the anticipation that these efforts will identify novel therapeutic targets. This study investigated the Petroselinum crispum extract in hepatic steatosis in rats fed with fructose enriched diet. Rats were divided into the 4 groups: Group 1 rats received standard pellet diet with corn starch for the entire experimental period of 8 weeks. Group 2 rats received standard pellet diet and 2 gm/kg body weight crude Parsley leaf ethanol extract for the entire experimental period of 8 weeks. Group 3 rats received modified fructose diet. Group 4 rats received modified fructose diet and 2gm/kg crude Parsley leaf ethanol extract. Hepatic function and structure was evaluated in these rats. Modified fructose diet produced dyslipidemia, hepatic steatosis and infiltration of inflammatory cells in the liver and higher plasma hepatic markers. Petroselinum crispum extract reversed metabolic changes such as abnormal crispum extract attenuated chronic changes in modified fructose diet induced NAFLD (Tab. 2, Fig. 3, Ref. 43).

Experimental and analytical studies of flow through a ventral and axial exhaust nozzle system for STOVL aircraft

NASA Technical Reports Server (NTRS)

Esker, Barbara S.; Debonis, James R.

1991-01-01

Flow through a combined ventral and axial exhaust nozzle system was studied experimentally and analytically. The work is part of an ongoing propulsion technology effort at NASA Lewis Research Center for short takeoff, vertical landing (STOVL) aircraft. The experimental investigation was done on the NASA Lewis Powered Lift Facility. The experiment consisted of performance testing over a range of tailpipe pressure ratios from 1 to 3.2 and flow visualization. The analytical investigation consisted of modeling the same configuration and solving for the flow using the PARC3D computational fluid dynamics program. The comparison of experimental and analytical results was very good. The ventral nozzle performance coefficients obtained from both the experimental and analytical studies agreed within 1.2 percent. The net horizontal thrust of the nozzle system contained a significant reverse thrust component created by the flow overturning in the ventral duct. This component resulted in a low net horizontal thrust coefficient. The experimental and analytical studies showed very good agreement in the internal flow patterns.

Low vulnerability explosives (LOVEX) for mass-use warheads

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pruneda, C.; Jessop, E.; McGuire, R.

1990-03-13

There is an ongoing effort at Lawrence Livermore National Laboratory to develop explosives with a significantly lower vulnerability to battlefield environments (bullets, fragments, sympathetic detonation) than current explosives (TNT and Comp B) without sacrificing performance or increasing costs. The approach taken is to develop a composite explosive which is comprised of inexpensive fillers such as RDX, NaNO{sub 3}, Al and a low modulus binder system. The binder system uses nitroglycerin/triacetin as an energetic plasticizer. This paper discusses the experimental results to date in vulnerability, performance and processing. 7 refs., 8 figs., 6 tabs.

Fostering synergy between cell biology and systems biology.

PubMed

Eddy, James A; Funk, Cory C; Price, Nathan D

2015-08-01

In the shared pursuit of elucidating detailed mechanisms of cell function, systems biology presents a natural complement to ongoing efforts in cell biology. Systems biology aims to characterize biological systems through integrated and quantitative modeling of cellular information. The process of model building and analysis provides value through synthesizing and cataloging information about cells and molecules, predicting mechanisms and identifying generalizable themes, generating hypotheses and guiding experimental design, and highlighting knowledge gaps and refining understanding. In turn, incorporating domain expertise and experimental data is crucial for building towards whole cell models. An iterative cycle of interaction between cell and systems biologists advances the goals of both fields and establishes a framework for mechanistic understanding of the genome-to-phenome relationship. Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.

The Need For Ongoing Surveys About Physician Practice Costs.

PubMed

Berk, Marc L

2016-09-01

Physicians continue to be the subject of many survey efforts asking them about a wide range of issues including training, retirement plans, satisfaction with practice, practice organization, and practice costs. The resources dedicated to the collection of different types of data have changed over time. Collection efforts have both expanded and contracted. Here I discuss this phenomenon for several types of physician surveys, with particular focus on the reduction in ongoing survey efforts about physician practice costs. The diminution of efforts to collect information about these costs represents an important challenge since the lack of timely, high-quality data could impair the correct calculation of reimbursement rates. Project HOPE—The People-to-People Health Foundation, Inc.

RELAP-7 Theory Manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berry, Ray Alden; Zou, Ling; Zhao, Haihua

This document summarizes the physical models and mathematical formulations used in the RELAP-7 code. In summary, the MOOSE based RELAP-7 code development is an ongoing effort. The MOOSE framework enables rapid development of the RELAP-7 code. The developmental efforts and results demonstrate that the RELAP-7 project is on a path to success. This theory manual documents the main features implemented into the RELAP-7 code. Because the code is an ongoing development effort, this RELAP-7 Theory Manual will evolve with periodic updates to keep it current with the state of the development, implementation, and model additions/revisions.

Durability of a continuous strand mat polymeric composite for automotive structural applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Corum, J.M.; McCoy, H.E. Jr.; Ruggles, M.B.

1995-12-31

A key unanswered question that must be addressed before polymeric composites will be widely used in automotive structural components is their durability. Major durability issues are the effects of cyclic loadings, creep, automotive environments, and low-energy impacts on dimensional stability, strength, and stiffness. The U.S. Department of Energy is sponsoring a project at Oak Ridge National Laboratory to address these issues and to develop, in cooperation with the Automotive Composites Consortium, experimentally based, durability driven, design guidelines. The initial reference material is an isocyanurate reinforced with a continuous strand, swirl glass mat. This paper describes the basic deformation and failuremore » behavior of the reference material, and it presents test results illustrating the property degradations caused by loading, time, and environmental effects. The importance of characterizing and understanding damage and how it leads to failure is also discussed. The results presented are from the initial phases of an ongoing project. The ongoing effort and plans are briefly described.« less

Sustained inflation during neonatal resuscitation.

PubMed

Keszler, Martin

2015-04-01

Sustained inflation performed shortly after birth to help clear lung fluid and establish functional residual capacity in preterm infants is gaining popularity, but definitive evidence for its effectiveness is lacking. Although there is a sound physiologic basis for this approach, and much preclinical experimental evidence of effectiveness, the results of recent animal studies and clinical trials have been inconsistent. The most recent data from a multicenter randomized trial suggest a modest benefit of sustained inflation in reducing the need for mechanical ventilation in extremely-low-birth-weight infants. However, the impact may be more modest than earlier retrospective cohort comparisons suggested. The trend toward more airleak and a higher rate of intraventricular hemorrhage is worrisome. Sustained inflation may be ineffective unless some spontaneous respiratory effort is present. Several on-going trials should further clarify the putative benefits of sustained inflation. Delivery room sustained inflation is an attractive concept that holds much promise, but widespread clinical application should await definitive evidence from on-going clinical trials.

Integrated microfluidic systems for cell lysis, mixing/pumping and DNA amplification

NASA Astrophysics Data System (ADS)

Lee, Chia-Yen; Lee, Gwo-Bin; Lin, Jr-Lung; Huang, Fu-Chun; Liao, Chia-Sheng

2005-06-01

The present paper reports a fully automated microfluidic system for the DNA amplification process by integrating an electroosmotic pump, an active micromixer and an on-chip temperature control system. In this DNA amplification process, the cell lysis is initially performed in a micro cell lysis reactor. Extracted DNA samples, primers and reagents are then driven electroosmotically into a mixing region where they are mixed by the active micromixer. The homogeneous mixture is then thermally cycled in a micro-PCR (polymerase chain reaction) chamber to perform DNA amplification. Experimental results show that the proposed device can successfully automate the sample pretreatment operation for DNA amplification, thereby delivering significant time and effort savings. The new microfluidic system, which facilitates cell lysis, sample driving/mixing and DNA amplification, could provide a significant contribution to ongoing efforts to miniaturize bio-analysis systems by utilizing a simple fabrication process and cheap materials.

Improving practices in nanomedicine through near real-time pharmacokinetic analysis

NASA Astrophysics Data System (ADS)

Magafia, Isidro B.

More than a decade into the development of gold nanoparticles, with multiple clinical trials underway, ongoing pre-clinical research continues towards better understanding in vivo interactions. The goal is treatment optimization through improved best practices. In an effort to collect information for healthcare providers enabling informed decisions in a relevant time frame, instrumentation for real-time plasma concentration (multi-wavelength photoplethysmography) and protocols for rapid elemental analysis (energy dispersive X-Ray fluorescence) of biopsied tumor tissue have been developed in a murine model. An initial analysis, designed to demonstrate the robust nature and utility of the techniques, revealed that area under the bioavailability curve (AUC) alone does not currently inform tumor accumulation with a high degree of accuracy (R2=0.56), marginally better than injected dose (R2=0.46). This finding suggests that the control of additional experimental and physiological variables (chosen through modeling efforts) may yield more predictable tumor accumulation. Subject core temperature, blood pressure, and tumor perfusion are evaluated relative to particle uptake in a murine tumor model. New research efforts are also focused on adjuvant therapies that are employed to modify circulation parameters, including the AUC, of nanorods and gold nanoshells. Preliminary studies demonstrated a greater than 300% increase in average AUC using a reticuloendothelial blockade agent versus control groups. Given a better understanding of the relative importance of the physiological factors that influence rates of tumor accumulation, a set of experimental best practices is presented. This dissertation outlines the experimental protocols conducted, and discusses the real-world needs discovered and how these needs became specifications of developed protocols.

77 FR 70123 - Retrospective Review Under Executive Order 13579

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-23

... ongoing review of its regulations related to the recent events at the Fukushima Dai-ichi Nuclear Power Plant in Japan; and (5) the NRC's previous and ongoing efforts to update its regulations in a systematic...

Biology and therapy of fibromyalgia. Evidence-based biomarkers for fibromyalgia syndrome

PubMed Central

Dadabhoy, Dina; Crofford, Leslie J; Spaeth, Michael; Russell, I Jon; Clauw, Daniel J

2008-01-01

Researchers studying fibromyalgia strive to identify objective, measurable biomarkers that may identify susceptible individuals, may facilitate diagnosis, or that parallel activity of the disease. Candidate objective measures range from sophisticated functional neuroimaging to office-ready measures of the pressure pain threshold. A systematic literature review was completed to assess highly investigated, objective measures used in fibromyalgia studies. To date, only experimental pain testing has been shown to coincide with improvements in clinical status in a longitudinal study. Concerted efforts to systematically evaluate additional objective measures in research trials will be vital for ongoing progress in outcome research and translation into clinical practice. PMID:18768089

Animal experimentation.

PubMed

Kolar, Roman

2006-01-01

Millions of animals are used every year in often times extremely painful and distressing scientific procedures. Legislation of animal experimentation in modern societies is based on the supposition that this is ethically acceptable when certain more or less defined formal (e.g. logistical, technical) demands and ethical principles are met. The main parameters in this context correspond to the "3Rs" concept as defined by Russel and Burch in 1959, i.e. that all efforts to replace, reduce and refine experiments must be undertaken. The licensing of animal experiments normally requires an ethical evaluation process, often times undertaken by ethics committees. The serious problems in putting this idea into practice include inter alia unclear conditions and standards for ethical decisions, insufficient management of experiments undertaken for specific (e.g. regulatory) purposes, and conflicts of interest of ethics committees' members. There is an ongoing societal debate about ethical issues of animal use in science. Existing EU legislation on animal experimentation for cosmetics testing is an example of both the public will for setting clear limits to animal experiments and the need to further critically examine other fields and aspects of animal experimentation.

Flexible manipulator control experiments and analysis

NASA Technical Reports Server (NTRS)

Yurkovich, S.; Ozguner, U.; Tzes, A.; Kotnik, P. T.

1987-01-01

Modeling and control design for flexible manipulators, both from an experimental and analytical viewpoint, are described. From the application perspective, an ongoing effort within the laboratory environment at the Ohio State University, where experimentation on a single link flexible arm is underway is described. Several unique features of this study are described here. First, the manipulator arm is slewed by a direct drive dc motor and has a rigid counterbalance appendage. Current experimentation is from two viewpoints: (1) rigid body slewing and vibration control via actuation with the hub motor, and (2) vibration suppression through the use of structure-mounted proof-mass actuation at the tip. Such an application to manipulator control is of interest particularly in design of space-based telerobotic control systems, but has received little attention to date. From an analytical viewpoint, parameter estimation techniques within the closed-loop for self-tuning adaptive control approaches are discussed. Also introduced is a control approach based on output feedback and frequency weighting to counteract effects of spillover in reduced-order model design. A model of the flexible manipulator based on experimental measurements is evaluated for such estimation and control approaches.

They See a Rat, We Seek a Cure for Diseases: The Current Status of Animal Experimentation in Medical Practice

PubMed Central

Kehinde, Elijah O.

2013-01-01

The objective of this review article was to examine current and prospective developments in the scientific use of laboratory animals, and to find out whether or not there are still valid scientific benefits of and justification for animal experimentation. The PubMed and Web of Science databases were searched using the following key words: animal models, basic research, pharmaceutical research, toxicity testing, experimental surgery, surgical simulation, ethics, animal welfare, benign, malignant diseases. Important relevant reviews, original articles and references from 1970 to 2012 were reviewed for data on the use of experimental animals in the study of diseases. The use of laboratory animals in scientific research continues to generate intense public debate. Their use can be justified today in the following areas of research: basic scientific research, use of animals as models for human diseases, pharmaceutical research and development, toxicity testing and teaching of new surgical techniques. This is because there are inherent limitations in the use of alternatives such as in vitro studies, human clinical trials or computer simulation. However, there are problems of transferability of results obtained from animal research to humans. Efforts are on-going to find suitable alternatives to animal experimentation like cell and tissue culture and computer simulation. For the foreseeable future, it would appear that to enable scientists to have a more precise understanding of human disease, including its diagnosis, prognosis and therapeutic intervention, there will still be enough grounds to advocate animal experimentation. However, efforts must continue to minimize or eliminate the need for animal testing in scientific research as soon as possible. PMID:24217224

They see a rat, we seek a cure for diseases: the current status of animal experimentation in medical practice.

PubMed

Kehinde, Elijah O

2013-01-01

The objective of this review article was to examine current and prospective developments in the scientific use of laboratory animals, and to find out whether or not there are still valid scientific benefits of and justification for animal experimentation. The PubMed and Web of Science databases were searched using the following key words: animal models, basic research, pharmaceutical research, toxicity testing, experimental surgery, surgical simulation, ethics, animal welfare, benign, malignant diseases. Important relevant reviews, original articles and references from 1970 to 2012 were reviewed for data on the use of experimental animals in the study of diseases. The use of laboratory animals in scientific research continues to generate intense public debate. Their use can be justified today in the following areas of research: basic scientific research, use of animals as models for human diseases, pharmaceutical research and development, toxicity testing and teaching of new surgical techniques. This is because there are inherent limitations in the use of alternatives such as in vitro studies, human clinical trials or computer simulation. However, there are problems of transferability of results obtained from animal research to humans. Efforts are on-going to find suitable alternatives to animal experimentation like cell and tissue culture and computer simulation. For the foreseeable future, it would appear that to enable scientists to have a more precise understanding of human disease, including its diagnosis, prognosis and therapeutic intervention, there will still be enough grounds to advocate animal experimentation. However, efforts must continue to minimize or eliminate the need for animal testing in scientific research as soon as possible. © 2013 S. Karger AG, Basel.

Comparisons of RELAP5-3D Analyses to Experimental Data from the Natural Convection Shutdown Heat Removal Test Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bucknor, Matthew; Hu, Rui; Lisowski, Darius

2016-04-17

The Reactor Cavity Cooling System (RCCS) is an important passive safety system being incorporated into the overall safety strategy for high temperature advanced reactor concepts such as the High Temperature Gas- Cooled Reactors (HTGR). The Natural Convection Shutdown Heat Removal Test Facility (NSTF) at Argonne National Laboratory (Argonne) reflects a 1/2-scale model of the primary features of one conceptual air-cooled RCCS design. The project conducts ex-vessel, passive heat removal experiments in support of Department of Energy Office of Nuclear Energy’s Advanced Reactor Technology (ART) program, while also generating data for code validation purposes. While experiments are being conducted at themore » NSTF to evaluate the feasibility of the passive RCCS, parallel modeling and simulation efforts are ongoing to support the design, fabrication, and operation of these natural convection systems. Both system-level and high fidelity computational fluid dynamics (CFD) analyses were performed to gain a complete understanding of the complex flow and heat transfer phenomena in natural convection systems. This paper provides a summary of the RELAP5-3D NSTF model development efforts and provides comparisons between simulation results and experimental data from the NSTF. Overall, the simulation results compared favorably to the experimental data, however, further analyses need to be conducted to investigate any identified differences.« less

HASP server: a database and structural visualization platform for comparative models of influenza A hemagglutinin proteins.

PubMed

Ambroggio, Xavier I; Dommer, Jennifer; Gopalan, Vivek; Dunham, Eleca J; Taubenberger, Jeffery K; Hurt, Darrell E

2013-06-18

Influenza A viruses possess RNA genomes that mutate frequently in response to immune pressures. The mutations in the hemagglutinin genes are particularly significant, as the hemagglutinin proteins mediate attachment and fusion to host cells, thereby influencing viral pathogenicity and species specificity. Large-scale influenza A genome sequencing efforts have been ongoing to understand past epidemics and pandemics and anticipate future outbreaks. Sequencing efforts thus far have generated nearly 9,000 distinct hemagglutinin amino acid sequences. Comparative models for all publicly available influenza A hemagglutinin protein sequences (8,769 to date) were generated using the Rosetta modeling suite. The C-alpha root mean square deviations between a randomly chosen test set of models and their crystallographic templates were less than 2 Å, suggesting that the modeling protocols yielded high-quality results. The models were compiled into an online resource, the Hemagglutinin Structure Prediction (HASP) server. The HASP server was designed as a scientific tool for researchers to visualize hemagglutinin protein sequences of interest in a three-dimensional context. With a built-in molecular viewer, hemagglutinin models can be compared side-by-side and navigated by a corresponding sequence alignment. The models and alignments can be downloaded for offline use and further analysis. The modeling protocols used in the HASP server scale well for large amounts of sequences and will keep pace with expanded sequencing efforts. The conservative approach to modeling and the intuitive search and visualization interfaces allow researchers to quickly analyze hemagglutinin sequences of interest in the context of the most highly related experimental structures, and allow them to directly compare hemagglutinin sequences to each other simultaneously in their two- and three-dimensional contexts. The models and methodology have shown utility in current research efforts and the ongoing aim of the HASP server is to continue to accelerate influenza A research and have a positive impact on global public health.

Treatment options after sorafenib failure in patients with hepatocellular carcinoma

PubMed Central

Dika, Imane El

2017-01-01

Second line therapy after failure of sorafenib continues to be under study. Prognosis of hepatocellular carcinoma is measured in months, with median overall survival reaching 10.7 months with sorafenib. Because of the modest net benefit sorafenib has contributed, and rising incidence of hepatocellular carcinoma in the world, continued efforts are ongoing to look for efficient upfront, second line, or combination therapies. Herein we review the most relevant to date published literature on treatment options beyond sorafenib, reported studies, ongoing investigational efforts, and possibilities for future studies in advanced hepatocellular carcinoma. PMID:29151326

Halophiles and their enzymes: Negativity put to good use

PubMed Central

DasSarma, Shiladitya; DasSarma, Priya

2015-01-01

Halophilic microorganisms possess stable enzymes that function in very high salinity, an extreme condition that leads to denaturation, aggregation, and precipitation of most other proteins. Genomic and structural analyses have established that the enzymes of halophilic Archaea and many halophilic Bacteria are negatively charged due to an excess of acidic over basic residues, and altered hydrophobicity, which enhance solubility and promote function in low water activity conditions. Here, we provide an update on recent bioinformatic analysis of predicted halophilic proteomes as well as experimental molecular studies on individual halophilic enzymes. On-going efforts on discovery and utilization of halophiles and their enzymes for biotechnology, including biofuel applications are also considered. PMID:26066288

Proliferation: Threat and Response

DTIC Science & Technology

1997-11-01

primary agent, the Defense Technology capabilities also contribute to ongoing efforts to Security Administration ( DTSA ). These efforts are focus and...Special Weapons Agency Organization DTSA Defense Technology Security BW Biological Weapons Administration BWC Biological and Toxin Weapons EPCI Enhanced

Alternative Fuel for Marine Application

DOT National Transportation Integrated Search

2012-02-29

The U.S. Maritime Administration (MARAD) is participating in the U.S. Navy's ongoing efforts to test alternative fuels for marine use by demonstrating their applicability on commercial vessels. In support of this effort, the Navy provided neat hydrot...

The digital revolution in phenotyping

PubMed Central

Oellrich, Anika; Collier, Nigel; Groza, Tudor; Rebholz-Schuhmann, Dietrich; Shah, Nigam; Bodenreider, Olivier; Boland, Mary Regina; Georgiev, Ivo; Liu, Hongfang; Livingston, Kevin; Luna, Augustin; Mallon, Ann-Marie; Manda, Prashanti; Robinson, Peter N.; Rustici, Gabriella; Simon, Michelle; Wang, Liqin; Winnenburg, Rainer; Dumontier, Michel

2016-01-01

Phenotypes have gained increased notoriety in the clinical and biological domain owing to their application in numerous areas such as the discovery of disease genes and drug targets, phylogenetics and pharmacogenomics. Phenotypes, defined as observable characteristics of organisms, can be seen as one of the bridges that lead to a translation of experimental findings into clinical applications and thereby support ‘bench to bedside’ efforts. However, to build this translational bridge, a common and universal understanding of phenotypes is required that goes beyond domain-specific definitions. To achieve this ambitious goal, a digital revolution is ongoing that enables the encoding of data in computer-readable formats and the data storage in specialized repositories, ready for integration, enabling translational research. While phenome research is an ongoing endeavor, the true potential hidden in the currently available data still needs to be unlocked, offering exciting opportunities for the forthcoming years. Here, we provide insights into the state-of-the-art in digital phenotyping, by means of representing, acquiring and analyzing phenotype data. In addition, we provide visions of this field for future research work that could enable better applications of phenotype data. PMID:26420780

Review of the Theoretical and Experimental Status of Dark Matter Identification with Cosmic-Ray Antideuterons

NASA Technical Reports Server (NTRS)

Aramaki, T.; Boggs, S.; Bufalino, S.; Dal, L.; von Doetinchem, P.; Donato, F.; Fornengo, N.; Fuke, H.; Grefe, M.; Hailey, C.;

Review of the theoretical and experimental status of dark matter identification with cosmic-ray antideuterons

DOE PAGES

Aramaki, T.; Boggs, S.; Bufalino, S.; ...

2016-01-27

Recent years have seen increased theoretical and experimental effort towards the first-ever detection of cosmic-ray antideuterons, in particular as an indirect signature of dark matter annihilation or decay. In contrast to indirect dark matter searches using positrons, antiprotons, or γ-rays, which suffer from relatively high and uncertain astrophysical backgrounds, searches with antideuterons benefit from very suppressed conventional backgrounds, offering a potential breakthrough in unexplored phase space for dark matter. This article is based on the first dedicated cosmic-ray antideuteron workshop, which was held at UCLA in June 2014. It reviews broad classes of dark matter candidates that result in detectablemore » cosmic-ray antideuteron fluxes, as well as the status and prospects of current experimental searches. The coalescence model of antideuteron production and the influence of antideuteron measurements at particle colliders are discussed. This is followed by a review of the modeling of antideuteron propagation through the magnetic fields, plasma currents, and molecular material of our Galaxy, the solar system, the Earth’s geomagnetic field, and the atmosphere. Lastly, the three ongoing or planned experiments that are sensitive to cosmic-ray antideuterons, BESS, AMS-02, and GAPS, are detailed. As cosmic-ray antideuteron detection is a rare event search, multiple experiments with orthogonal techniques and backgrounds are essential. Furthermore, the combination of AMS-02 and GAPS antideuteron searches is highly desirable. Many theoretical and experimental groups have contributed to these studies over the last decade, this review aims to provide the first coherent discussion of the relevant dark matter theories that antideuterons probe, the challenges to predictions and interpretations of antideuteron signals, and the experimental efforts toward cosmic antideuteron detection.« less

Stormtime Magnetosphere-Ionosphere-Thermosphere Interactions and Dynamics

DTIC Science & Technology

2013-03-13

1 2. BACKGROUND ... BACKGROUND The studies described in this report were performed in support of ongoing and planned space weather programs in the areas of Space Situational...Ionosphere The purpose of this effort was to initiate on-going analysis of COSMIC -GPS measurements of total electron content (TEC) in the dayside

Exposure Modeling Tools and Databases for Consideration for Relevance to the Amended TSCA (ISES)

EPA Science Inventory

The Agency’s Office of Research and Development (ORD) has a number of ongoing exposure modeling tools and databases. These efforts are anticipated to be useful in supporting ongoing implementation of the amended Toxic Substances Control Act (TSCA). Under ORD’s Chemic...

Progress in European CELSS activities

NASA Technical Reports Server (NTRS)

Skoog, A. I.

1987-01-01

The European Controlled Ecological Life Support System (CELSS) activities started in the late 1970's with system analysis and feasibility studies of Biological Life Support Systems (BLSS). The initiation for CELSS came from the industry side in Europe, but since then planning and hardware feasibility analyses have been initiated also from customer/agency side. Despite this, it is still too early to state that a CELSS program as a concerted effort has been agreed upon in Europe. However, the general CELSS objectives were accepted as planning and possible development goals for the European effort for manned space activities, and as experimental planning topics in the life sciences community for the next decades. It is expected that ecological life support systems can be tested and implemented on a space station towards the end of this century or early in the next. For the European activities a possible scenario can be projected based on ongoing life support system development activities and the present life sciences goals.

Borophene as a prototype for synthetic 2D materials development.

PubMed

Mannix, Andrew J; Zhang, Zhuhua; Guisinger, Nathan P; Yakobson, Boris I; Hersam, Mark C

2018-06-01

The synthesis of 2D materials with no analogous bulk layered allotropes promises a substantial breadth of physical and chemical properties through the diverse structural options afforded by substrate-dependent epitaxy. However, despite the joint theoretical and experimental efforts to guide materials discovery, successful demonstrations of synthetic 2D materials have been rare. The recent synthesis of 2D boron polymorphs (that is, borophene) provides a notable example of such success. In this Perspective, we discuss recent progress and future opportunities for borophene research. Borophene combines unique mechanical properties with anisotropic metallicity, which complements the canon of conventional 2D materials. The multi-centre characteristics of boron-boron bonding lead to the formation of configurationally varied, vacancy-mediated structural motifs, providing unprecedented diversity in a mono-elemental 2D system with potential for electronic applications, chemical functionalization, materials synthesis and complex heterostructures. With its foundations in computationally guided synthesis, borophene can serve as a prototype for ongoing efforts to discover and exploit synthetic 2D materials.

Borophene as a prototype for synthetic 2D materials development

NASA Astrophysics Data System (ADS)

Mannix, Andrew J.; Zhang, Zhuhua; Guisinger, Nathan P.; Yakobson, Boris I.; Hersam, Mark C.

2018-06-01

The synthesis of 2D materials with no analogous bulk layered allotropes promises a substantial breadth of physical and chemical properties through the diverse structural options afforded by substrate-dependent epitaxy. However, despite the joint theoretical and experimental efforts to guide materials discovery, successful demonstrations of synthetic 2D materials have been rare. The recent synthesis of 2D boron polymorphs (that is, borophene) provides a notable example of such success. In this Perspective, we discuss recent progress and future opportunities for borophene research. Borophene combines unique mechanical properties with anisotropic metallicity, which complements the canon of conventional 2D materials. The multi-centre characteristics of boron-boron bonding lead to the formation of configurationally varied, vacancy-mediated structural motifs, providing unprecedented diversity in a mono-elemental 2D system with potential for electronic applications, chemical functionalization, materials synthesis and complex heterostructures. With its foundations in computationally guided synthesis, borophene can serve as a prototype for ongoing efforts to discover and exploit synthetic 2D materials.

DART -- Data acquisition for the next generation of Fermilab fixed target experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oleynik, G.; Anderson, J.; Appleton, L.

1994-02-01

DART is the name of the data acquisition effort for Fermilab experiments taking data in the '94--'95 time frame and beyond. Its charge is to provide a common system of hardware and software, which can be easily configured and extended to meet the wide range of data acquisition requirements of the experiments. Its strategy is to provide incrementally functional data acquisition systems to the experiments at frequent intervals to support the ongoing DA activities of the experiments. DART is a collaborative development effort between the experimenters and the Fermilab Computing Division. Experiments collaborating in DART cover a range of requirementsmore » from 400 Kbytes/sec event readout using a single DA processor, to 200 Mbytes/sec event readout involving 10 parallel readout streams, 10 VME event building planes and greater than 1,000 MIPs of event filter processing. The authors describe the requirements, architecture, and plans for the project and report on its current status.« less

Final Technical Report for Award DE-FG02-98ER41080

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Alan

The prime motivation of the project at McMaster University was to carry out the critical evaluation and compilation of Nuclear Structure and Decay data, and of nuclear astrophysics data with continued participation in the United States Nuclear Data Program (US-NDP). A large body of evaluated and compiled structure data were supplied for databases such as ENSDF, XUNDL, NSR, etc. residing on webpage of National Nuclear Data Center of the Brookhaven National Laboratory, Upton, New York, USA. Thermonuclear reaction rates of importance to stellar explosions, such as novae, x-ray bursts and supernovae, were evaluated as well. This effort was closely coupledmore » to our ongoing experimental effort, which took advantage of radioactive ion beam and stable beam facilities worldwide to study these key reaction rates. This report contains brief descriptions of the various activities together with references to all the publications in peer-reviewed journals which were the result of work carried out with the award DE-FG02-98-ER41080, during 1998-2013.« less

Near-Source Modeling Updates: Building Downwash & Near-Road

EPA Science Inventory

The presentation describes recent research efforts in near-source model development focusing on building downwash and near-road barriers. The building downwash section summarizes a recent wind tunnel study, ongoing computational fluid dynamics simulations and efforts to improve ...

IDENTIFICATION OF CFC AND HCFC SUBSTITUTES FOR BLOWING POLYURETHANE FOAM INSULATION PRODUCTS

EPA Science Inventory

The report gives results of a cooperative effort to identiry chlorofluorocarbons and hydrochlorofluorocarbon substitutes for blowing polyurethane foam insulation products. The substantial ongoing effort is identifying third-generation blowing agets for polyurethane foams to repla...

Development of an inter-atomic potential for the Pd-H binary system.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zimmerman, Jonathan A.; Hoyt, Jeffrey John; Leonard, Francois Leonard

2007-09-01

Ongoing research at Sandia National Laboratories has been in the area of developing models and simulation methods that can be used to uncover and illuminate the material defects created during He bubble growth in aging bulk metal tritides. Previous efforts have used molecular dynamics calculations to examine the physical mechanisms by which growing He bubbles in a Pd metal lattice create material defects. However, these efforts focused only on the growth of He bubbles in pure Pd and not on bubble growth in the material of interest, palladium tritide (PdT), or its non-radioactive isotope palladium hydride (PdH). The reason formore » this is that existing inter-atomic potentials do not adequately describe the thermodynamics of the Pd-H system, which includes a miscibility gap that leads to phase separation of the dilute (alpha) and concentrated (beta) alloys of H in Pd at room temperature. This document will report the results of research to either find or develop inter-atomic potentials for the Pd-H and Pd-T systems, including our efforts to use experimental data and density functional theory calculations to create an inter-atomic potential for this unique metal alloy system.« less

Testing and modeling of PBX-9591 shock initiation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lam, Kim; Foley, Timothy; Novak, Alan

2010-01-01

This paper describes an ongoing effort to develop a detonation sensitivity test for PBX-9501 that is suitable for studying pristine and damaged HE. The approach involves testing and comparing the sensitivities of HE pressed to various densities and those of pre-damaged samples with similar porosities. The ultimate objectives are to understand the response of pre-damaged HE to shock impacts and to develop practical computational models for use in system analysis codes for HE safety studies. Computer simulation with the CTH shock physics code is used to aid the experimental design and analyze the test results. In the calculations, initiation andmore » growth or failure of detonation are modeled with the empirical HVRB model. The historical LANL SSGT and LSGT were reviewed and it was determined that a new, modified gap test be developed to satisfy the current requirements. In the new test, the donor/spacer/acceptor assembly is placed in a holder that is designed to work with fixtures for pre-damaging the acceptor sample. CTH simulations were made of the gap test with PBX-9501 samples pressed to three different densities. The calculated sensitivities were validated by test observations. The agreement between the computed and experimental critical gap thicknesses, ranging from 9 to 21 mm under various test conditions, is well within 1 mm. These results show that the numerical modeling is a valuable complement to the experimental efforts in studying and understanding shock initiation of PBX-9501.« less

Toxicology of chemical mixtures: Experimental approaches, underlying concepts, and some results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, R.S.; Long, H.L.; Boorman, G.A.

1990-07-01

The toxicology of chemical mixtures will be the toxicology of the 1990s and beyond. While this branch of toxicology most closely reflects the actual human exposure situation, as yet there is no standard protocol or consensus methodology for investigating the toxicology of mixtures. Thus, in this emerging science, experimentation is required just to develop a broadly applicable evaluation system. Several examples are discussed to illustrate the different experimental designs and the concepts behind each. These include the health effects studies of Love Canal soil samples, the Lake Ontario Coho salmon, the water samples repurified from secondary sewage in the citymore » of Denver Potable Water Reuse Demonstration Plant, and the National Toxicology Program (NTP) effort on a mixture of 25 frequently detected groundwater contaminants derived from hazardous waste disposal sites. In the last instance, an extensive research program has been ongoing for the last two years at the NTP, encompassing general toxicology, immunotoxicology, developmental and reproductive toxicology, biochemical toxicology, myelotoxicology, genetic toxicology, neurobehavioral toxicology, and hepato- and renal toxicology.« less

Supersonic Retropropulsion Experimental Results from the NASA Langley Unitary Plan Wind Tunnel

NASA Technical Reports Server (NTRS)

Berry, Scott A.; Rhode, Matthew N.; Edquist, Karl T.; Player, Charles J.

2011-01-01

A new supersonic retropropulsion experimental effort, intended to provide code validation data, was recently completed in the Langley Research Center Unitary Plan Wind Tunnel Test Section 2 over the Mach number range from 2.4 to 4.6. The experimental model was designed using insights gained from pre-test computations, which were instrumental for sizing and refining the model to minimize tunnel wall interference and internal flow separation concerns. A 5-in diameter 70-deg sphere-cone forebody with a roughly 10-in long cylindrical aftbody was the baseline configuration selected for this study. The forebody was designed to accommodate up to four 4:1 area ratio supersonic nozzles. Primary measurements for this model were a large number of surface pressures on the forebody and aftbody. Supplemental data included high-speed Schlieren video and internal pressures and temperatures. The run matrix was developed to allow for the quantification of various sources of experimental uncertainty, such as random errors due to run-to-run variations and bias errors due to flow field or model misalignments. Preliminary results and observations from the test are presented, while detailed data and uncertainty analyses are ongoing.

Computerized Planning of Cryosurgery Using Bubble Packing: An Experimental Validation on a Phantom Material

PubMed Central

Rossi, Michael R.; Tanaka, Daigo; Shimada, Kenji; Rabin, Yoed

2009-01-01

The current study focuses on experimentally validating a planning scheme based on the so-called bubble-packing method. This study is a part of an ongoing effort to develop computerized planning tools for cryosurgery, where bubble packing has been previously developed as a means to find an initial, uniform distribution of cryoprobes within a given domain; the so-called force-field analogy was then used to move cryoprobes to their optimum layout. However, due to the high quality of the cryoprobes’ distribution, suggested by bubble packing and its low computational cost, it has been argued that a planning scheme based solely on bubble packing may be more clinically relevant. To test this argument, an experimental validation is performed on a simulated cross-section of the prostate, using gelatin solution as a phantom material, proprietary liquid-nitrogen based cryoprobes, and a cryoheater to simulate urethral warming. Experimental results are compared with numerically simulated temperature histories resulting from planning. Results indicate an average disagreement of 0.8 mm in identifying the freezing front location, which is an acceptable level of uncertainty in the context of prostate cryosurgery imaging. PMID:19885373

Repositioning Science Reform Efforts: Four Practical Recommendations from the Field

ERIC Educational Resources Information Center

Ness, Daniel; Farenga, Stephen J.; Shah, Vishal; Garofalo, Salvatore G.

2016-01-01

Appeals to reform science education by policy makers are not new phenomena. To be sure, while science reform efforts have been ongoing occurrences for nearly six decades, perpetual educational reform efforts as a whole have been evolving and gaining momentum in number for more than a century. The general motivation for continual reform appears to…

40 CFR Appendix W to Part 51 - Guideline on Air Quality Models

Code of Federal Regulations, 2013 CFR

2013-07-01

... in the Guideline. The third activity is the extensive on-going research efforts by EPA and others in... addition, findings from ongoing research programs, new model development, or results from model evaluations... shown that the model is not biased toward underestimates; and v. A protocol on methods and procedures to...

40 CFR Appendix W to Part 51 - Guideline on Air Quality Models

Code of Federal Regulations, 2012 CFR

2012-07-01

... in the Guideline. The third activity is the extensive on-going research efforts by EPA and others in... addition, findings from ongoing research programs, new model development, or results from model evaluations... shown that the model is not biased toward underestimates; and v. A protocol on methods and procedures to...

40 CFR Appendix W to Part 51 - Guideline on Air Quality Models

Code of Federal Regulations, 2014 CFR

2014-07-01

... in the Guideline. The third activity is the extensive on-going research efforts by EPA and others in... addition, findings from ongoing research programs, new model development, or results from model evaluations... shown that the model is not biased toward underestimates; and v. A protocol on methods and procedures to...

Development and Preparation of Lead-Containing Paint Films and Diagnostic Test Materials

EPA Science Inventory

Lead in paint continues to be a threat to children’s health in cities across the United States, which means there is an ongoing need for testing and analysis of paint. This ongoing analytical effort and especially development of new methods continue to drive the need for diagnost...

VBA: A Probabilistic Treatment of Nonlinear Models for Neurobiological and Behavioural Data

PubMed Central

Daunizeau, Jean; Adam, Vincent; Rigoux, Lionel

2014-01-01

This work is in line with an on-going effort tending toward a computational (quantitative and refutable) understanding of human neuro-cognitive processes. Many sophisticated models for behavioural and neurobiological data have flourished during the past decade. Most of these models are partly unspecified (i.e. they have unknown parameters) and nonlinear. This makes them difficult to peer with a formal statistical data analysis framework. In turn, this compromises the reproducibility of model-based empirical studies. This work exposes a software toolbox that provides generic, efficient and robust probabilistic solutions to the three problems of model-based analysis of empirical data: (i) data simulation, (ii) parameter estimation/model selection, and (iii) experimental design optimization. PMID:24465198

Ocean acidification postcards

USGS Publications Warehouse

Schreppel, Heather A.; Cimitile, Matthew J.

2011-01-01

The U.S. Geological Survey (USGS) is conducting research on ocean acidification in polar, temperate, subtropical, and tropical regions including the Arctic, West Florida Shelf, and the Caribbean. Project activities include field assessment, experimental laboratory studies, and evaluation of existing data. The USGS is participating in international and interagency working groups to develop research strategies to increase understanding of the global implications of ocean acidification. Research strategies include new approaches for seawater chemistry observation and modeling, assessment of physiological effects on organisms, changes in marine ecosystem structure, new technologies, and information resources. These postcards highlight ongoing USGS research efforts in ocean acidification and carbon cycling in marine and coastal ecosystems in three different regions: polar, temperate, and tropical. To learn more about ocean acidification visit: http://coastal.er.usgs.gov/ocean-acidification/.

Counterfeit Electronics Detection Using Image Processing and Machine Learning

NASA Astrophysics Data System (ADS)

Asadizanjani, Navid; Tehranipoor, Mark; Forte, Domenic

2017-01-01

Counterfeiting is an increasing concern for businesses and governments as greater numbers of counterfeit integrated circuits (IC) infiltrate the global market. There is an ongoing effort in experimental and national labs inside the United States to detect and prevent such counterfeits in the most efficient time period. However, there is still a missing piece to automatically detect and properly keep record of detected counterfeit ICs. Here, we introduce a web application database that allows users to share previous examples of counterfeits through an online database and to obtain statistics regarding the prevalence of known defects. We also investigate automated techniques based on image processing and machine learning to detect different physical defects and to determine whether or not an IC is counterfeit.

Procedures and Concepts of EPA's Ongoing Sensor Evaluation Efforts

EPA Science Inventory

The purpose of this research effort was to develop an understanding of what technology might prove valuable in conducting the next generation of air monitoring. Upon their discovery, such technologies were obtained in collaboration with inventors and commercial and research orga...

High-Temperature Structures, Adhesives, and Advanced Thermal Protection Materials for Next-Generation Aeroshell Design

NASA Technical Reports Server (NTRS)

Collins, Timothy J.; Congdon, William M.; Smeltzer, Stanley S.; Whitley, Karen S.

2005-01-01

The next generation of planetary exploration vehicles will rely heavily on robust aero-assist technologies, especially those that include aerocapture. This paper provides an overview of an ongoing development program, led by NASA Langley Research Center (LaRC) and aimed at introducing high-temperature structures, adhesives, and advanced thermal protection system (TPS) materials into the aeroshell design process. The purpose of this work is to demonstrate TPS materials that can withstand the higher heating rates of NASA's next generation planetary missions, and to validate high-temperature structures and adhesives that can reduce required TPS thickness and total aeroshell mass, thus allowing for larger science payloads. The effort described consists of parallel work in several advanced aeroshell technology areas. The areas of work include high-temperature adhesives, high-temperature composite materials, advanced ablator (TPS) materials, sub-scale demonstration test articles, and aeroshell modeling and analysis. The status of screening test results for a broad selection of available higher-temperature adhesives is presented. It appears that at least one (and perhaps a few) adhesives have working temperatures ranging from 315-400 C (600-750 F), and are suitable for TPS-to-structure bondline temperatures that are significantly above the traditional allowable of 250 C (482 F). The status of mechanical testing of advanced high-temperature composite materials is also summarized. To date, these tests indicate the potential for good material performance at temperatures of at least 600 F. Application of these materials and adhesives to aeroshell systems that incorporate advanced TPS materials may reduce aeroshell TPS mass by 15% - 30%. A brief outline is given of work scheduled for completion in 2006 that will include fabrication and testing of large panels and subscale aeroshell test articles at the Solar-Tower Test Facility located at Kirtland AFB and operated by Sandia National Laboratories. These tests are designed to validate aeroshell manufacturability using advanced material systems, and to demonstrate the maintenance of bondline integrity at realistically high temperatures and heating rates. Finally, a status is given of ongoing aeroshell modeling and analysis efforts which will be used to correlate with experimental testing, and to provide a reliable means of extrapolating to performance under actual flight conditions. The modeling and analysis effort includes a parallel series of experimental tests to determine TSP thermal expansion and other mechanical properties which are required for input to the analysis models.

Overview of Fluid Dynamics Activities at the Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

Garcia, Roberto; Griffin, Lisa W.; Wang, Ten-See

1999-01-01

Since its inception 40 years ago, Marshall Space Flight Center (MSFC) has had the need to maintain and advance state-of-the-art flow analysis and cold-flow testing capability to support its roles and missions. This overview discusses the recent organizational changes that have occurred at MSFC with emphasis on the resulting three groups that form the core of fluid dynamics expertise at MSFC: the Fluid Physics and Dynamics Group, the Applied Fluid Dynamics Analysis Group, and the Experimental Fluid Dynamics Group. Recently completed activities discussed include the analysis and flow testing in support of the Fastrac engine design, the X-33 vehicle design, and the X34 propulsion system design. Ongoing activities include support of the RLV vehicle design, Liquid Fly Back Booster aerodynamic configuration definition, and RLV focused technologies development. Other ongoing activities discussed are efforts sponsored by the Center Director's Discretionary Fund (CDDF) to develop an advanced incompressible flow code and to develop optimization techniques. Recently initiated programs and their anticipated required fluid dynamics support are discussed. Based on recent experiences and on the anticipated program needs, required analytical and experimental technique improvements are presented. Due to anticipated budgetary constraints, there is a strong need to leverage activities and to pursue teaming arrangements in order to advance the state-of-the-art and to adequately support concept development. Throughout this overview there is discussion of the lessons learned and of the capabilities demonstrated and established in support of the hardware development programs.

Experimental and Numerical Study on Performance of Ducted Hydrokinetic Turbines with Pre-Swirl Stator Blades.

NASA Astrophysics Data System (ADS)

Gish, Andrew

2015-11-01

Ducts (also called shrouds) have been shown to improve performance of hydrokinetic turbines in some situations, bringing the power coefficient (Cp) closer to the Betz limit. Here we investigate optimization of the duct design as well as the addition of stator blades upstream of the turbine rotor to introduce pre-swirl in the flow. A small scale three-bladed turbine was tested in a towing tank. Three cases (bare turbine, with duct, and with duct and stators) were tested over a range of flow speeds. Important parameters include duct cross-sectional shape, blade-duct gap, stator cross-sectional shape, and stator angle. For each test, Cp was evaluated as a function of tip speed ratio (TSR). Experimental results were compared with numerical simulations. Results indicate that ducts and stators can improve performance at slower flow speeds and lower the stall speed compared to a bare turbine, but may degrade performance at higher speeds. Ongoing efforts to optimize duct and stator configurations will be discussed.

Neural Network Based Models for Fusion Applications

NASA Astrophysics Data System (ADS)

Meneghini, Orso; Tema Biwole, Arsene; Luda, Teobaldo; Zywicki, Bailey; Rea, Cristina; Smith, Sterling; Snyder, Phil; Belli, Emily; Staebler, Gary; Canty, Jeff

2017-10-01

Whole device modeling, engineering design, experimental planning and control applications demand models that are simultaneously physically accurate and fast. This poster reports on the ongoing effort towards the development and validation of a series of models that leverage neural-­network (NN) multidimensional regression techniques to accelerate some of the most mission critical first principle models for the fusion community, such as: the EPED workflow for prediction of the H-Mode and Super H-Mode pedestal structure the TGLF and NEO models for the prediction of the turbulent and neoclassical particle, energy and momentum fluxes; and the NEO model for the drift-kinetic solution of the bootstrap current. We also applied NNs on DIII-D experimental data for disruption prediction and quantifying the effect of RMPs on the pedestal and ELMs. All of these projects were supported by the infrastructure provided by the OMFIT integrated modeling framework. Work supported by US DOE under DE-SC0012656, DE-FG02-95ER54309, DE-FC02-04ER54698.

Efforts to Bridge the Gap between Research and Practice in Social Work: Precedents and Prospects: Keynote Address at the Bridging the Gap Symposium

ERIC Educational Resources Information Center

Rubin, Allen

2015-01-01

This keynote address discusses previous and ongoing efforts to reduce the persistent gap between research and practice in social work and offers recommendations for further bridging that gap. Key among those recommendations is the need to conduct descriptive outcome studies of efforts to adapt research-supported interventions in everyday practice…

NASA and The Semantic Web

NASA Technical Reports Server (NTRS)

Ashish, Naveen

2005-01-01

We provide an overview of several ongoing NASA endeavors based on concepts, systems, and technology from the Semantic Web arena. Indeed NASA has been one of the early adopters of Semantic Web Technology and we describe ongoing and completed R&D efforts for several applications ranging from collaborative systems to airspace information management to enterprise search to scientific information gathering and discovery systems at NASA.

Towards Systematic Benchmarking of Climate Model Performance

NASA Astrophysics Data System (ADS)

Gleckler, P. J.

2014-12-01

The process by which climate models are evaluated has evolved substantially over the past decade, with the Coupled Model Intercomparison Project (CMIP) serving as a centralizing activity for coordinating model experimentation and enabling research. Scientists with a broad spectrum of expertise have contributed to the CMIP model evaluation process, resulting in many hundreds of publications that have served as a key resource for the IPCC process. For several reasons, efforts are now underway to further systematize some aspects of the model evaluation process. First, some model evaluation can now be considered routine and should not require "re-inventing the wheel" or a journal publication simply to update results with newer models. Second, the benefit of CMIP research to model development has not been optimal because the publication of results generally takes several years and is usually not reproducible for benchmarking newer model versions. And third, there are now hundreds of model versions and many thousands of simulations, but there is no community-based mechanism for routinely monitoring model performance changes. An important change in the design of CMIP6 can help address these limitations. CMIP6 will include a small set standardized experiments as an ongoing exercise (CMIP "DECK": ongoing Diagnostic, Evaluation and Characterization of Klima), so that modeling groups can submit them at any time and not be overly constrained by deadlines. In this presentation, efforts to establish routine benchmarking of existing and future CMIP simulations will be described. To date, some benchmarking tools have been made available to all CMIP modeling groups to enable them to readily compare with CMIP5 simulations during the model development process. A natural extension of this effort is to make results from all CMIP simulations widely available, including the results from newer models as soon as the simulations become available for research. Making the results from routine performance tests readily accessible will help advance a more transparent model evaluation process.

Factors in Sustaining Professional Learning Community

ERIC Educational Resources Information Center

Kilbane, James F., Jr.

2009-01-01

School change efforts to develop schools as learning communities result in schools that are constantly learning and thus changing. This collective case study of four schools involved in a 4-year reform effort begins to examine the ongoing sustainability of a learning community. The study draws insights about the sustainability of learning…

The use of real-time optical feedback to improve outcomes

NASA Astrophysics Data System (ADS)

Magaña, Isidro B.; Adhikari, Pratik; Yendluri, Raghuvara B.; Goodrich, Glenn P.; Schwartz, Jon A.; O'Neal, D. P.

2014-03-01

More than a decade into the development of gold nanoparticles for cancer therapies, with multiple clinical trials underway, ongoing pre-clinical research continues towards better understanding in vivo interactions with the goal of treatment optimization through improved best practices. In an effort to collect information for healthcare providers, enabling informed decisions in a relevant time frame, instrumentation for real-time plasma concentration (multi-wavelength pulse photometry) and protocols for rapid elemental analysis (energy dispersive X-Ray fluorescence) of biopsied tumor tissue have been developed in a murine model. An initial analysis, designed to demonstrate the robust nature and utility of the techniques, revealed that area under the bioavailability curve (AUC) alone does not currently inform tumor accumulation with a high degree of accuracy (R2=0.32), This finding suggests that the control of additional experimental and physiological variables may yield more predictable tumor accumulation. Subject core temperature are blood pressure were monitored, but did not demonstrate clear trends. An effort to modulate AUC has produced an adjuvant therapy which is employed to enhance circulation parameters, including the AUC, of nanorods and gold nanoshells. Preliminary studies demonstrated a greater than 300% increase in average AUC through the use of a reticuloendothelial blockade agent versus control groups. Given a better understanding of the relative importance of the physiological factors which impact rates of tumor accumulation, a proposed set of experimental best practices is presented.

Hardware Progress Made in the Early Flight Fission Test Facilities (EFF-TF) To Support Near-Term Space Fission Systems

NASA Astrophysics Data System (ADS)

Van Dyke, Melissa; Martin, James

2005-02-01

The NASA Marshall Space Flight Center's Early Flight Fission Test Facility (EFF-TF), provides a facility to experimentally evaluate nuclear reactor related thermal hydraulic issues through the use of non-nuclear testing. This facility provides a cost effective method to evaluate concepts/designs and support mitigation of developmental risk. Electrical resistance thermal simulators can be used to closely mimic the heat deposition of the fission process, providing axial and radial profiles. A number of experimental and design programs were underway in 2004 which include the following. Initial evaluation of the Department of Energy Los Alamos National Laboratory 19 module stainless steel/sodium heat pipe reactor with integral gas heat exchanger was operated at up to 17.5 kW of input power at core temperatures of 1000 K. A stainless steel sodium heat pipe module was placed through repeated freeze/thaw cyclic testing accumulating over 200 restarts to a temperature of 1000 K. Additionally, the design of a 37- pin stainless steel pumped sodium/potassium (NaK) loop was finalized and components procured. Ongoing testing at the EFF-TF is geared towards facilitating both research and development necessary to support future decisions regarding potential use of space nuclear systems for space exploration. All efforts are coordinated with DOE laboratories, industry, universities, and other NASA centers. This paper describes some of the 2004 efforts.

Hardware Progress Made in the Early Flight Fission Test Facilities (EFF-TF) To Support Near-Term Space Fission Systems

NASA Technical Reports Server (NTRS)

VanDyke, Melissa; Martin, James

2005-01-01

The EFF-TF provides a facility to experimentally evaluate thermal hydraulic issues through the use of highly effective non-nuclear testing. These techniques provide a rapid, more cost effective method of evaluating designs and support development risk mitigation when concerns are associated with non-nuclear aspects of space nuclear systems. For many systems, electrical resistance thermal simulators can be used to closely mimic the heat deposition of the fission process, providing axial and radial profiles. A number of experimental and design programs were underway in 2004. Initial evaluation of the SAFE-100a (19 module stainless steel/sodium heat pipe reactor with integral gas neat exchanger) was performed with tests up to 17.5 kW of input power at core temperatures of 1000 K. A stainless steel sodium SAFE-100 heat pipe module was placed through repeated freeze/thaw cyclic testing accumulating over 200 restarts to a temperature of 1000 K. Additionally, the design of a 37-fuel pin stainless steel pumped sodium/potassium (NaK) loop was finalized and components procured. Ongoing testing at the EFF-TF is geared towards facilitating both research and development necessary to field a near term space nuclear system. Efforts are coordinated with DOE laboratories, industry, universities, and other NASA centers. This paper describes some of the 2004 efforts.

Continuum modeling of neuronal cell under blast loading

PubMed Central

Jérusalem, Antoine; Dao, Ming

2012-01-01

Traumatic brain injuries have recently been put under the spotlight as one of the most important causes of accidental brain dysfunctions. Significant experimental and modeling efforts are thus ongoing to study the associated biological, mechanical and physical mechanisms. In the field of cell mechanics, progresses are also being made at the experimental and modeling levels to better characterize many of the cell functions such as differentiation, growth, migration and death, among others. The work presented here aims at bridging both efforts by proposing a continuum model of neuronal cell submitted to blast loading. In this approach, cytoplasm, nucleus and membrane (plus cortex) are differentiated in a representative cell geometry, and different material constitutive models are adequately chosen for each one. The material parameters are calibrated against published experimental work of cell nanoindentation at multiple rates. The final cell model is ultimately subjected to blast loading within a complete fluid-structure interaction computational framework. The results are compared to the nanoindentation simulation and the specific effects of the blast wave on the pressure and shear levels at the interfaces are identified. As a conclusion, the presented model successfully captures some of the intrinsic intracellular phenomena occurring during its deformation under blast loading and potentially leading to cell damage. It suggests more particularly the localization of damage at the nucleus membrane similarly to what has already been observed at the overall cell membrane. This degree of damage is additionally predicted to be worsened by a longer blast positive phase duration. As a conclusion, the proposed model ultimately provides a new three dimensional computational tool to evaluate intracellular damage during blast loading. PMID:22562014

Stochastic Hybrid Systems Modeling and Middleware-enabled DDDAS for Next-generation US Air Force Systems

DTIC Science & Technology

2017-03-30

experimental evaluations for hosting DDDAS-like applications in public cloud infrastructures . Finally, we report on ongoing work towards using the DDDAS...developed and their experimental evaluations for hosting DDDAS-like applications in public cloud infrastructures . Finally, we report on ongoing work towards...Dynamic resource management, model learning, simulation-based optimizations, cloud infrastructures for DDDAS applications. I. INTRODUCTION Critical cyber

Time to finger point or fix? An invitation to join ongoing efforts to promote ethical authorship and other good publication practices.

PubMed

Woolley, Karen L; Gertel, Art; Hamilton, Cindy W; Jacobs, Adam; Snyder, Gene P

2013-01-01

In this commentary, we present evidence that unethical authorship (eg, guest and ghost authoring) and other publication practices are not restricted to the pharmaceutical industry; they also occur in academia. Such practices are not an industry problem--they are a research problem. To enhance trust in industry-sponsored research, companies have made rapid and far-reaching changes to their publication guidelines, policies, and procedures. Professional medical writers have adopted, and continue to implement, these changes. Although evidence indicates that industry practices are improving, there is certainly more to do, both in industry and academia. We invite readers to join ongoing efforts to promote ethical publication practices.

Universality of the logarithmic velocity profile restored

NASA Astrophysics Data System (ADS)

Luchini, Paolo

2017-11-01

The logarithmic velocity profile of wall-bounded turbulent flow, despite its widespread adoption in research and in teaching, exhibits discrepancies with both experiments and numerical simulations that have been repeatedly observed in the literature; serious doubts ensued about its precise form and universality, leading to the formulation of alternate theories and hindering ongoing experimental efforts to measure von Kármán's constant. By comparing different geometries of pipe, plane-channel and plane-Couette flow, here we show that such discrepancies can be physically interpreted, and analytically accounted for, through an equally universal higher-order correction caused by the pressure gradient. Inclusion of this term produces a tenfold increase in the adherence of the predicted profile to existing experiments and numerical simulations in all three geometries. Universality of the logarithmic law then emerges beyond doubt and a satisfactorily simple formulation is established. Among the consequences of this formulation is a strongly increased confidence that the Reynolds number of present-day direct numerical simulations is actually high enough to uncover asymptotic behaviour, but research efforts are still needed in order to increase their accuracy.

Integration of cloud-based storage in BES III computing environment

NASA Astrophysics Data System (ADS)

Wang, L.; Hernandez, F.; Deng, Z.

2014-06-01

We present an on-going work that aims to evaluate the suitability of cloud-based storage as a supplement to the Lustre file system for storing experimental data for the BES III physics experiment and as a backend for storing files belonging to individual members of the collaboration. In particular, we discuss our findings regarding the support of cloud-based storage in the software stack of the experiment. We report on our development work that improves the support of CERN' s ROOT data analysis framework and allows efficient remote access to data through several cloud storage protocols. We also present our efforts providing the experiment with efficient command line tools for navigating and interacting with cloud storage-based data repositories both from interactive sessions and grid jobs.

An Interlaboratory Comparison of Dosimetry for a Multi-institutional Radiobiological

PubMed Central

Seed, TM; Xiao, S; Manley, N; Nikolich-Zugich, J; Pugh, J; van den Brink, M; Hirabayashi, Y; Yasutomo, K; Iwama, A; Koyasu, S; Shterev, I; Sempowski, G; Macchiarini, F; Nakachi, K; Kunugi, KC; Hammer, CG; DeWerd, LA

2016-01-01

Purpose An interlaboratory comparison of radiation dosimetry was conducted to determine the accuracy of doses being used experimentally for animal exposures within a large multi-institutional research project. The background and approach to this effort are described and discussed in terms of basic findings, problems and solutions. Methods Dosimetry tests were carried out utilizing optically stimulated luminescence (OSL) dosimeters embedded midline into mouse carcasses and thermal luminescence dosimeters (TLD) embedded midline into acrylic phantoms. Results The effort demonstrated that the majority (4/7) of the laboratories was able to deliver sufficiently accurate exposures having maximum dosing errors of ≤ 5%. Comparable rates of ‘dosimetric compliance’ were noted between OSL- and TLD-based tests. Data analysis showed a highly linear relationship between ‘measured’ and ‘target’ doses, with errors falling largely between 0–20%. Outliers were most notable for OSL-based tests, while multiple tests by ‘non-compliant’ laboratories using orthovoltage x-rays contributed heavily to the wide variation in dosing errors. Conclusions For the dosimetrically non-compliant laboratories, the relatively high rates of dosing errors were problematic, potentially compromising the quality of ongoing radiobiological research. This dosimetry effort proved to be instructive in establishing rigorous reviews of basic dosimetry protocols ensuring that dosing errors were minimized. PMID:26857121

An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: Observations, problems, solutions and lessons learned.

PubMed

Seed, Thomas M; Xiao, Shiyun; Manley, Nancy; Nikolich-Zugich, Janko; Pugh, Jason; Van den Brink, Marcel; Hirabayashi, Yoko; Yasutomo, Koji; Iwama, Atsushi; Koyasu, Shigeo; Shterev, Ivo; Sempowski, Gregory; Macchiarini, Francesca; Nakachi, Kei; Kunugi, Keith C; Hammer, Clifford G; Dewerd, Lawrence A

2016-01-01

An interlaboratory comparison of radiation dosimetry was conducted to determine the accuracy of doses being used experimentally for animal exposures within a large multi-institutional research project. The background and approach to this effort are described and discussed in terms of basic findings, problems and solutions. Dosimetry tests were carried out utilizing optically stimulated luminescence (OSL) dosimeters embedded midline into mouse carcasses and thermal luminescence dosimeters (TLD) embedded midline into acrylic phantoms. The effort demonstrated that the majority (4/7) of the laboratories was able to deliver sufficiently accurate exposures having maximum dosing errors of ≤5%. Comparable rates of 'dosimetric compliance' were noted between OSL- and TLD-based tests. Data analysis showed a highly linear relationship between 'measured' and 'target' doses, with errors falling largely between 0 and 20%. Outliers were most notable for OSL-based tests, while multiple tests by 'non-compliant' laboratories using orthovoltage X-rays contributed heavily to the wide variation in dosing errors. For the dosimetrically non-compliant laboratories, the relatively high rates of dosing errors were problematic, potentially compromising the quality of ongoing radiobiological research. This dosimetry effort proved to be instructive in establishing rigorous reviews of basic dosimetry protocols ensuring that dosing errors were minimized.

Creating a Statewide Educational Data System for Accountability and Improvement: A Comprehensive Information and Assessment System for Making Evidence-Based Change at School, District, and Policy Levels

ERIC Educational Resources Information Center

Felner, Robert D.; Bolton, Natalie; Seitsinger, Anne M.; Brand, Stephen; Burns, Amy

2008-01-01

This article reports on one ongoing statewide effort to create a high-quality data reporting and utilization system (i.e., High-Performance Learning Community [HiPlaces] Assessment) to inform educational accountability and improvement efforts system. This effort has undergoing refinement for more than a decade. The article describes the features…

Achieving a Prioritized Research and Technology Development Portfolio for the Dust Management Project

NASA Technical Reports Server (NTRS)

Hyatt, Mark J.; Abel, Phillip; Delaune, Paul; Fishman, Julianna; Kohli, Rajiv

2009-01-01

Mission architectures for human exploration of the lunar surface continue to advance as well as the definitions of capability needs, best practices and engineering design to mitigate the impact of lunar dust on exposed systems. The NASA DMP has been established as the agency focal point for dust characterization, technology, and simulant development. As described in this paper, the DMP has defined a process for selecting and justifying its R&T portfolio. The technology prioritization process, which is based on a ranking system according to weighted criteria, has been successfully applied to the current DMP dust mitigation technology portfolio. Several key findings emerged from this assessment. Within the dust removal and cleaning technologies group, there are critical technical challenges that must be overcome for these technologies to be implemented for lunar applications. For example, an in-situ source of CO2 on the moon is essential to the CO2 shower technology. Also, significant development effort is required to achieve technology readiness level TRL 6 for the electrostatic cleaning system for removal of particles smaller than 50 pm. The baseline materials related technologies require considerable development just to achieve TRL 6. It is also a nontrivial effort to integrate the materials in hardware for lunar application. At present, there are no terrestrial applications that are readily adaptable to lunar surface applications nor are there any obvious leading candidates. The unique requirements of dust sealing systems for lunar applications suggest an extensive development effort will be necessary to mature dust sealing systems to TRL 6 and beyond. As discussed here, several alternate materials and technologies have achieved high levels of maturity for terrestrial applications and warrant due diligence in ongoing assessment of the technology portfolio. The present assessment is the initial step in an ongoing effort to continually evaluate the DMP technology portfolio and external non-NASA relevant technology developments efforts to maintain an optimal investment profile. At the same time, there is an ongoing review of agency-wide dust-related R&T activities. The results of these ongoing assessments will be reported in future publications.

Integrating Phosphorus Movement with Soil and Water Loss in the Daily Erosion Project

NASA Astrophysics Data System (ADS)

Sklenar, Tim; Perez-Bidegain, Mario; Cruse, Richard; Gelder, Brian; Herzmann, Daryl

2016-04-01

The Daily Erosion Project (DEP) is an ongoing modelling effort which is now in its second generation. DEP provides comprehensive and dynamic estimates of sediment delivery, soil erosion, and hill slope runoff for agricultural land areas across the Midwestern United States every day for Hydrologic Unit Code 12 (HUC 12) size watersheds. Results are posted every morning on the Internet at dailyerosion.org. Currently DEP covers all of Iowa and portions of Kansas and Minnesota, but expansion of coverage is ongoing. The integration of highly resolute spatial and temporal climate data, soil properties, crop rotation and residue management data affords the opportunity to test the effects of using multiple conservation practices on the transport and fate of water borne nutrients, especially phosphorus, on the Midwestern United States agricultural landscapes. Understanding the interaction of different environmental and land management practices on phosphorus movement will allow data from the DEP to guide conservation efforts as expansion continues into surrounding Midwestern states. The presentation will provide an overview of the DEP technology, including how input data are derived and used to make daily erosion estimates on over 200,000 flowpaths in the modelling area, as well as a discussion of the ongoing phosphorus transport modelling efforts and plans for future expansion (both land area and model functionality).

High Temperature Irradiation-Resistant Thermocouple Performance Improvements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Joshua Daw; Joy Rempe; Darrell Knudson

2009-04-01

Traditional methods for measuring temperature in-pile degrade at temperatures above 1100 ºC. To address this instrumentation need, the Idaho National Laboratory (INL) developed and evaluated the performance of a high temperature irradiation-resistant thermocouple (HTIR-TC) that contains alloys of molybdenum and niobium. Data from high temperature (up to 1500 ºC) long duration (up to 4000 hours) tests and on-going irradiations at INL’s Advanced Test Reactor demonstrate the superiority of these sensors to commercially-available thermocouples. However, several options have been identified that could further enhance their reliability, reduce their production costs, and allow their use in a wider range of operating conditions.more » This paper presents results from on-going Idaho National Laboratory (INL)/University of Idaho (UI) efforts to investigate options to improve HTIR-TC ductility, reliability, and resolution by investigating specially-formulated alloys of molybdenum and niobium and alternate diameter thermoelements (wires). In addition, on-going efforts to evaluate alternate fabrication approaches, such as drawn and loose assembly techniques will be discussed. Efforts to reduce HTIR-TC fabrication costs, such as the use of less expensive extension cable will also be presented. Finally, customized HTIR-TC designs developed for specific customer needs will be summarized to emphasize the varied conditions under which these sensors may be used.« less

Current status and ongoing conservation efforts for the federally endangered species Pityopsis ruthii

USDA-ARS?s Scientific Manuscript database

Pityopsis ruthii is an endangered species endemic to the Hiwassee and Ocoee rivers in Tennessee. Due to limited information regarding biology and genetics of P. ruthii, our research over the past 6 years have focused on conservation and recovery efforts. Using applied and molecular techniques, a bas...

The Need for Large-Scale, Longitudinal Empirical Studies in Middle Level Education Research

ERIC Educational Resources Information Center

Mertens, Steven B.; Caskey, Micki M.; Flowers, Nancy

2016-01-01

This essay describes and discusses the ongoing need for large-scale, longitudinal, empirical research studies focused on middle grades education. After a statement of the problem and concerns, the essay describes and critiques several prior middle grades efforts and research studies. Recommendations for future research efforts to inform policy…

75 FR 82053 - Notification of a New Privacy Act System of Records, Effort to Outcomes-Case Management System...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-29

... to facilitate on-going tracking and management of these services, leading to greater self-sufficiency... Congress. Comments Due Date: January 28, 2011. ADDRESSES: Interested persons are invited to submit comments... SYSTEM NAME: Efforts to Outcome Case Management Tracking System for DHAP-Ike. SYSTEM LOCATION: Baltimore...

Standing for Just and Right Decisions: The Long, Slow Path to School Safety.

ERIC Educational Resources Information Center

LeCompte, Margaret D.

2000-01-01

Describes one high school's 20-year struggle to create a safe school environment following race riots and sexual harassment of young women. Notes that these ongoing efforts set the pattern for the school's current efforts to provide equal protection for gay, lesbian, bisexual, transgendered, and queer/questioning students. (SM)

International Multidisciplinary Learning: An Account of a Collaborative Effort among Three Higher Education Institutions

ERIC Educational Resources Information Center

Poh, Paul S. H.; Soetanto, Robby; Austin, Stephen; Adamu, Zulkifar A.

2014-01-01

Requiring students to complete their course assignments in partnership and in collaboration with students from other institutions is not commonplace teaching pedagogy. Even less so when they transcend disciplines and international borders. This paper presents a brief account of an ongoing collaborative effort between Ryerson University, Coventry…

EVA Communications Avionics and Informatics

NASA Technical Reports Server (NTRS)

Carek, David Andrew

2005-01-01

The Glenn Research Center is investigating and developing technologies for communications, avionics, and information systems that will significantly enhance extra vehicular activity capabilities to support the Vision for Space Exploration. Several of the ongoing research and development efforts are described within this presentation including system requirements formulation, technology development efforts, trade studies, and operational concept demonstrations.

Rapid Release From Listening Effort Resulting From Semantic Context, and Effects of Spectral Degradation and Cochlear Implants

PubMed Central

2016-01-01

People with hearing impairment are thought to rely heavily on context to compensate for reduced audibility. Here, we explore the resulting cost of this compensatory behavior, in terms of effort and the efficiency of ongoing predictive language processing. The listening task featured predictable or unpredictable sentences, and participants included people with cochlear implants as well as people with normal hearing who heard full-spectrum/unprocessed or vocoded speech. The crucial metric was the growth of the pupillary response and the reduction of this response for predictable versus unpredictable sentences, which would suggest reduced cognitive load resulting from predictive processing. Semantic context led to rapid reduction of listening effort for people with normal hearing; the reductions were observed well before the offset of the stimuli. Effort reduction was slightly delayed for people with cochlear implants and considerably more delayed for normal-hearing listeners exposed to spectrally degraded noise-vocoded signals; this pattern of results was maintained even when intelligibility was perfect. Results suggest that speed of sentence processing can still be disrupted, and exertion of effort can be elevated, even when intelligibility remains high. We discuss implications for experimental and clinical assessment of speech recognition, in which good performance can arise because of cognitive processes that occur after a stimulus, during a period of silence. Because silent gaps are not common in continuous flowing speech, the cognitive/linguistic restorative processes observed after sentences in such studies might not be available to listeners in everyday conversations, meaning that speech recognition in conventional tests might overestimate sentence-processing capability. PMID:27698260

Towards the Third Wave of School Effectiveness and Improvement in Hong Kong: Internal, Interface and Future.

ERIC Educational Resources Information Center

Cheng, Yin Cheong

This presentation reports on three waves of reform efforts for school effectiveness and improvement in Hong Kong, and analyzes related challenges and issues with the hope of drawing international implications for ongoing research and reform efforts in different parts of the world. These three waves represent paradigm shifts and different…

A variable-instar climate-driven individual beetle-based phenology model for the invasive Asian longhorned beetle (Coleoptera: Cerambycidae)

Treesearch

R. Talbot Trotter, III; Melody A. Keena

2016-01-01

Efforts to manage and eradicate invasive species can benefit from an improved understanding of the physiology, biology, and behavior of the target species, and ongoing efforts to eradicate the Asian longhorned beetle (Anoplophora glabripennis Motschulsky) highlight the roles this information may play. Here, we present a climate-driven phenology...

Building and Sustaining Talent: Creating Conditions in High-Poverty Schools That Support Effective Teaching and Learning

ERIC Educational Resources Information Center

Almy, Sarah; Tooley, Melissa

2012-01-01

Improving teaching effectiveness is a hot topic for policymakers around the country these days. The gathering movement marks an important step forward in the ongoing effort to strengthen our nation's schools. In many cases, however, these efforts start and stop with improving outdated, inadequate teacher evaluation systems. Such approaches fail to…

USDA Gin Lab Updates

USDA-ARS?s Scientific Manuscript database

This presentation provides an update to ginning industry stakeholders on current research efforts ongoing at the three USDA ARS ginning laboratories in Lubbock, TX, Stoneville, MS, and Mesilla Park, NM....

TMDL Implementation: Lessons Learned

EPA Pesticide Factsheets

Virginia Tech Center for TMDL and Watershed Studies provided state TMDL implementation information and reviewed ongoing TMDL implementation efforts across the country to identify factors that contribute to successful implementation.

Simulation and Optimization of Vacuum Swing Adsorption Units for Spacesuit Carbon Dioxide and Humidity Control

NASA Technical Reports Server (NTRS)

Swickrath, Michael J.; Anderson, Molly; McMillin, Summer; Broerman, Craig

2010-01-01

Controlling carbon dioxide (CO2) and humidity levels in a spacesuit is critical to ensuring both the safety and comfort of an astronaut during extra-vehicular activity (EVA). Traditionally, this has been accomplished utilizing non-regenerative lithium hydroxide (LiOH) or regenerative metal oxide (MetOx) canisters which pose a significant weight burden. Although such technology enables air revitalization, the volume requirements to store the waste canisters as well as the mass to transport multiple units become prohibitive as mission durations increase. Consequently, motivation exists toward developing a fully regenerative technology for environmental control. The application of solid amine materials with vacuum swing adsorption technology has shown the capacity to control CO2 and concomitantly manage humidity levels through a fully regenerative cycle eliminating mission constraints imposed with non-regenerative technologies. Experimental results for full-size and sub-scale test articles have been collected and are described herein. In order to accelerate the developmental efforts, an axially-dispersed plug ow model with an accompanying energy balance has been established and correlated with the experimental data. The experimental and simulation results display good agreement for a variety of ow rates (110-170 SLM), replicated metabolic challenges (100-590 Watts), and atmosphere pressures under consideration for the spacesuit (248 and 760 mm Hg). The relationship between swing adsorption cycles for an outlet criterion of 6.0 mm Hg of CO2 partial pressure has been established for each metabolic challenge. In addition, variable metabolic profiles were imposed on the test articles in order to assess the ability of the technology to transition to new operational constraints. The advent of the model provides the capacity to apply computer-aided engineering practices to support the ongoing efforts to optimize and mature this technology for future application to space exploration.

The Atomic Mass Evaluation (AME2012): Status and Perspectives

NASA Astrophysics Data System (ADS)

Kondev, F. G.; Audi, G.; Wang, M.; Xu, X.; Wapstra, A. H.; MacCormick, M.; Pfeiffer, B.

2013-10-01

The atomic mass is a fundamental property of the nucleus that has wide applications in natural sciences and technology. The new evaluated mass table, AME2012, has been recently published as a collaborative effort between scientists from China, Europe and USA, under the leadership of G. Audi. It represents a significant update of the previous AME2003 evaluation by considering a large number of precise experimental results obtained at existing Penning Trap and Storage Ring facilities, thus expending the region of experimentally known masses towards exotic neutron- and proton-rich nuclei. Since the presence of isomers plays an important role in determining the masses of many nuclei, a complementary database, NUBASE2012, that contains the isomer-level properties for all nuclei was also developed. This presentation will briefly review recent achievements of the collaboration, present on-going activities, and reflect on ideas for future developments and challenges in the field of evaluation of atomic masses. The work at ANL was supported by the U.S. Department of Energy, Office of Nuclear Physics, under Contract No. DE-AC02-06CH11357.

A Dynamic Calibration Method for Experimental and Analytical Hub Load Comparison

NASA Technical Reports Server (NTRS)

Kreshock, Andrew R.; Thornburgh, Robert P.; Wilbur, Matthew L.

2017-01-01

This paper presents the results from an ongoing effort to produce improved correlation between analytical hub force and moment prediction and those measured during wind-tunnel testing on the Aeroelastic Rotor Experimental System (ARES), a conventional rotor testbed commonly used at the Langley Transonic Dynamics Tunnel (TDT). A frequency-dependent transformation between loads at the rotor hub and outputs of the testbed balance is produced from frequency response functions measured during vibration testing of the system. The resulting transformation is used as a dynamic calibration of the balance to transform hub loads predicted by comprehensive analysis into predicted balance outputs. In addition to detailing the transformation process, this paper also presents a set of wind-tunnel test cases, with comparisons between the measured balance outputs and transformed predictions from the comprehensive analysis code CAMRAD II. The modal response of the testbed is discussed and compared to a detailed finite-element model. Results reveal that the modal response of the testbed exhibits a number of characteristics that make accurate dynamic balance predictions challenging, even with the use of the balance transformation.

Global Surrogates for the Upshift of the Critical Threshold in the Gradient for ITG Driven Turbulence

NASA Astrophysics Data System (ADS)

Michoski, Craig; Janhunen, Salomon; Faghihi, Danial; Carey, Varis; Moser, Robert

2017-10-01

The suppression of micro-turbulence and ultimately the inhibition of large-scale instabilities observed in tokamak plasmas is partially characterized by the onset of a global stationary state. This stationary attractor corresponds experimentally to a state of ``marginal stability'' in the plasma. The critical threshold that characterizes the onset in the nonlinear regime is observed both experimentally and numerically to exhibit an upshift relative to the linear theory. That is, the onset in the stationary state is up-shifted from those predicted by the linear theory as a function of the ion temperature gradient R0 /LT . Because the transition to this state with enhanced transport and therefore reduced confinement times is inaccessible to the linear theory, strategies for developing nonlinear reduced physics models to predict the upshift have been ongoing. As a complement to these effort, the principle aim of this work is to establish low-fidelity surrogate models that can be used to predict instability driven loss of confinement using training data from high-fidelity models. DE-SC0008454 and DE-AC02-09CH11466.

Animal models of post-ischemic forced use rehabilitation: methods, considerations, and limitations

PubMed Central

2013-01-01

Many survivors of stroke experience arm impairments, which can severely impact their quality of life. Forcing use of the impaired arm appears to improve functional recovery in post-stroke hemiplegic patients, however the mechanisms underlying improved recovery remain unclear. Animal models of post-stroke rehabilitation could prove critical to investigating such mechanisms, however modeling forced use in animals has proven challenging. Potential problems associated with reported experimental models include variability between stroke methods, rehabilitation paradigms, and reported outcome measures. Herein, we provide an overview of commonly used stroke models, including advantages and disadvantages of each with respect to studying rehabilitation. We then review various forced use rehabilitation paradigms, and highlight potential difficulties and translational problems. Lastly, we discuss the variety of functional outcome measures described by experimental researchers. To conclude, we outline ongoing challenges faced by researchers, and the importance of translational communication. Many stroke patients rely critically on rehabilitation of post-stroke impairments, and continued effort toward progression of rehabilitative techniques is warranted to ensure best possible treatment of the devastating effects of stroke. PMID:23343500

Fiber Lasers and Amplifiers for Space-based Science and Exploration

NASA Technical Reports Server (NTRS)

Yu, Anthony W.; Krainak, Michael A.; Stephen, Mark A.; Chen, Jeffrey R.; Coyle, Barry; Numata, Kenji; Camp, Jordan; Abshire, James B.; Allan, Graham R.; Li, Steven X.;

Internal fluid mechanics research on supercomputers for aerospace propulsion systems

NASA Technical Reports Server (NTRS)

Miller, Brent A.; Anderson, Bernhard H.; Szuch, John R.

1988-01-01

The Internal Fluid Mechanics Division of the NASA Lewis Research Center is combining the key elements of computational fluid dynamics, aerothermodynamic experiments, and advanced computational technology to bring internal computational fluid mechanics (ICFM) to a state of practical application for aerospace propulsion systems. The strategies used to achieve this goal are to: (1) pursue an understanding of flow physics, surface heat transfer, and combustion via analysis and fundamental experiments, (2) incorporate improved understanding of these phenomena into verified 3-D CFD codes, and (3) utilize state-of-the-art computational technology to enhance experimental and CFD research. Presented is an overview of the ICFM program in high-speed propulsion, including work in inlets, turbomachinery, and chemical reacting flows. Ongoing efforts to integrate new computer technologies, such as parallel computing and artificial intelligence, into high-speed aeropropulsion research are described.

Multi-tissue DNA methylation age: Molecular relationships and perspectives for advancing biomarker utility.

PubMed

Nwanaji-Enwerem, Jamaji C; Weisskopf, Marc G; Baccarelli, Andrea A

2018-04-23

The multi-tissue DNA methylation estimator of chronological age (DNAm-age) has been associated with a wide range of exposures and health outcomes. Still, it is unclear how DNAm-age can have such broad relationships and how it can be best utilized as a biomarker. Understanding DNAm-age's molecular relationships is a promising approach to address this critical knowledge gap. In this review, we discuss the existing literature regarding DNAm-age's molecular relationships in six major categories: animal model systems, cancer processes, cellular aging processes, immune system processes, metabolic processes, and nucleic acid processes. We also present perspectives regarding the future of DNAm-age research, including the need to translate a greater number of ongoing research efforts to experimental and animal model systems. Copyright © 2018 Elsevier B.V. All rights reserved.

Three-Photon-Annihilation Contributions to Positronium Energies at Order m α7

NASA Astrophysics Data System (ADS)

Adkins, Gregory S.; Kim, Minji; Parsons, Christian; Fell, Richard N.

2015-12-01

Positronium spectroscopy (n =1 hyperfine splitting, n =2 fine structure, and the 2 S -1 S interval) has reached a precision of order 1 MHz. Vigorous ongoing efforts to improve the experimental results motivate the calculation of the positronium energy levels at order m α7. In this Letter, we present the result for a complete class of such contributions—those involving virtual annihilation of positronium to three photons in an intermediate state. We find an energy shift of 2.6216 (11 )m α7/(n π )3=11.5 /n3 kHz for the spin-triplet S state with principal quantum number n . The corresponding energy shift for true muonium (the μ+μ- bound state) is 2.38 /n3 MHz with an additional -5.33 /n3 MHz coming from electronic vacuum polarization.

Microchannel plate special nuclear materials sensor

NASA Astrophysics Data System (ADS)

Feller, W. B.; White, P. L.; White, P. B.; Siegmund, O. H. W.; Martin, A. P.; Vallerga, J. V.

2011-10-01

Nova Scientific Inc., is developing for the Domestic Nuclear Detection Office (DNDO SBIR #HSHQDC-08-C-00190), a solid-state, high-efficiency neutron detection alternative to 3He gas tubes, using neutron-sensitive microchannel plates (MCPs) containing 10B and/or Gd. This work directly supports DNDO development of technologies designed to detect and interdict nuclear weapons or illicit nuclear materials. Neutron-sensitized MCPs have been shown theoretically and more recently experimentally, to be capable of thermal neutron detection efficiencies equivalent to 3He gas tubes. Although typical solid-state neutron detectors typically have an intrinsic gamma sensitivity orders of magnitude higher than that of 3He gas detectors, we dramatically reduce gamma sensitivity by combining a novel electronic coincidence rejection scheme, employing a separate but enveloping gamma scintillator. This has already resulted in a measured gamma rejection ratio equal to a small 3He tube, without in principle sacrificing neutron detection efficiency. Ongoing improvements to the MCP performance as well as the coincidence counting geometry will be described. Repeated testing and validation with a 252Cf source has been underway throughout the Phase II SBIR program, with ongoing comparisons to a small commercial 3He gas tube. Finally, further component improvements and efforts toward integration maturity are underway, with the goal of establishing functional prototypes for SNM field testing.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rutqvist, Jonny; Blanco Martin, Laura; Mukhopadhyay, Sumit

The modeling efforts in support of the field test planning conducted at LBNL leverage on recent developments of tools for modeling coupled thermal-hydrological-mechanical-chemical (THMC) processes in salt and their effect on brine migration at high temperatures. This work includes development related to, and implementation of, essential capabilities, as well as testing the model against relevant information and published experimental data related to the fate and transport of water. These are modeling capabilities that will be suitable for assisting in the design of field experiment, especially related to multiphase flow processes coupled with mechanical deformations, at high temperature. In this report,more » we first examine previous generic repository modeling results, focusing on the first 20 years to investigate the expected evolution of the different processes that could be monitored in a full-scale heater experiment, and then present new results from ongoing modeling of the Thermal Simulation for Drift Emplacement (TSDE) experiment, a heater experiment on the in-drift emplacement concept at the Asse Mine, Germany, and provide an update on the ongoing model developments for modeling brine migration. LBNL also supported field test planning activities via contributions to and technical review of framework documents and test plans, as well as participation in workshops associated with field test planning.« less

The Quality of Feeling.

ERIC Educational Resources Information Center

Wilkinson, Andrew

1985-01-01

Describes the efforts of the Crediton Project, an ongoing research project in Devon, England, to develop an assessment scheme that accounts for cognitive, affective, moral, and stylistic development in children's writing. (DF)

The Fukushima nuclear disaster is ongoing.

PubMed

Marks, Andrew R

2016-07-01

The 5th anniversary of the Fukushima disaster and the 30th anniversary of the Chernobyl disaster, the two most catastrophic nuclear accidents in history, both occurred recently. Images of Chernobyl are replete with the international sign of radioactive contamination (a circle with three broad spokes radiating outward in a yellow sign). In contrast, ongoing decontamination efforts at Fukushima lack international warnings about radioactivity. Decontamination workers at Fukushima appear to be poorly protected against radiation. It is almost as if the effort is to make the Fukushima problem disappear. A more useful response would be to openly acknowledge the monumental problems inherent in managing a nuclear plant disaster. Lessons from Chernobyl are the best predictors of what the Fukushima region of Japan is coping with in terms of health and environmental problems following a nuclear catastrophe.

Focus on cumulative emissions, global carbon budgets and the implications for climate mitigation targets

NASA Astrophysics Data System (ADS)

Damon Matthews, H.; Zickfeld, Kirsten; Knutti, Reto; Allen, Myles R.

2018-01-01

The Environmental Research Letters focus issue on ‘Cumulative Emissions, Global Carbon Budgets and the Implications for Climate Mitigation Targets’ was launched in 2015 to highlight the emerging science of the climate response to cumulative emissions, and how this can inform efforts to decrease emissions fast enough to avoid dangerous climate impacts. The 22 research articles published represent a fantastic snapshot of the state-or-the-art in this field, covering both the science and policy aspects of cumulative emissions and carbon budget research. In this Review and Synthesis, we summarize the findings published in this focus issue, outline some suggestions for ongoing research needs, and present our assessment of the implications of this research for ongoing efforts to meet the goals of the Paris climate agreement.

Future use of digital remote sensing data

NASA Technical Reports Server (NTRS)

Spann, G. W.; Jones, N. L.

1978-01-01

Users of remote sensing data are increasingly turning to digital processing techniques for the extraction of land resource, environmental, and natural resource information. This paper presents the results of recent and ongoing research efforts sponsored, in part, by NASA/Marshall Space Flight Center on the current uses of and future needs for digital remote sensing data. An ongoing investigation involves a comprehensive survey of capabilities for digital Landsat data use in the Southeastern U.S. Another effort consists of an evaluation of future needs for digital remote sensing data by federal, state, and local governments and the private sector. These needs are projected into the 1980-1985 time frame. Furthermore, the accelerating use of digital remote sensing data is not limited to the U.S. or even to the developed countries of the world.

Usefulness of a Competency-Based Reflective Portfolio for Student Learning on a Masters Health Promotion Programme

ERIC Educational Resources Information Center

McKenna, Verna; Connolly, Claire; Hodgins, Margaret

2011-01-01

Background: Efforts to identify core competencies within health promotion and health education have been on-going for a number of years. These efforts include work carried out by the International Union for Health Promotion and Education (IUHPE) in drawing up a draft list of 11 core competencies which were incorporated into the practice module on…

Organizing principles as tools for bridging the gap between system theory and biological experimentation.

PubMed

Mekios, Constantinos

2016-04-01

Twentieth-century theoretical efforts towards the articulation of general system properties came short of having the significant impact on biological practice that their proponents envisioned. Although the latter did arrive at preliminary mathematical formulations of such properties, they had little success in showing how these could be productively incorporated into the research agenda of biologists. Consequently, the gap that kept system-theoretic principles cut-off from biological experimentation persisted. More recently, however, simple theoretical tools have proved readily applicable within the context of systems biology. In particular, examples reviewed in this paper suggest that rigorous mathematical expressions of design principles, imported primarily from engineering, could produce experimentally confirmable predictions of the regulatory properties of small biological networks. But this is not enough for contemporary systems biologists who adopt the holistic aspirations of early systemologists, seeking high-level organizing principles that could provide insights into problems of biological complexity at the whole-system level. While the presented evidence is not conclusive about whether this strategy could lead to the realization of the lofty goal of a comprehensive explanatory integration, it suggests that the ongoing quest for organizing principles is pragmatically advantageous for systems biologists. The formalisms postulated in the course of this process can serve as bridges between system-theoretic concepts and the results of molecular experimentation: they constitute theoretical tools for generalizing molecular data, thus producing increasingly accurate explanations of system-wide phenomena.

Nuclear Explosion Monitoring Advances and Challenges

NASA Astrophysics Data System (ADS)

Baker, G. E.

2015-12-01

We address the state-of-the-art in areas important to monitoring, current challenges, specific efforts that illustrate approaches addressing shortcomings in capabilities, and additional approaches that might be helpful. The exponential increase in the number of events that must be screened as magnitude thresholds decrease presents one of the greatest challenges. Ongoing efforts to exploit repeat seismic events using waveform correlation, subspace methods, and empirical matched field processing holds as much "game-changing" promise as anything being done, and further efforts to develop and apply such methods efficiently are critical. Greater accuracy of travel time, signal loss, and full waveform predictions are still needed to better locate and discriminate seismic events. Important developments include methods to model velocities using multiple types of data; to model attenuation with better separation of source, path, and site effects; and to model focusing and defocusing of surface waves. Current efforts to model higher frequency full waveforms are likely to improve source characterization while more effective estimation of attenuation from ambient noise holds promise for filling in gaps. Censoring in attenuation modeling is a critical problem to address. Quantifying uncertainty of discriminants is key to their operational use. Efforts to do so for moment tensor (MT) inversion are particularly important, and fundamental progress on the statistics of MT distributions is the most important advance needed in the near term in this area. Source physics is seeing great progress through theoretical, experimental, and simulation studies. The biggest need is to accurately predict the effects of source conditions on seismic generation. Uniqueness is the challenge here. Progress will depend on studies that probe what distinguishes mechanisms, rather than whether one of many possible mechanisms is consistent with some set of observations.

Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges

PubMed Central

Bruni, Anthony; Gala-Lopez, Boris; Pepper, Andrew R; Abualhassan, Nasser S; Shapiro, AM James

2014-01-01

Islet transplantation is a well-established therapeutic treatment for a subset of patients with complicated type I diabetes mellitus. Prior to the Edmonton Protocol, only 9% of the 267 islet transplant recipients since 1999 were insulin independent for >1 year. In 2000, the Edmonton group reported the achievement of insulin independence in seven consecutive patients, which in a collaborative team effort propagated expansion of clinical islet transplantation centers worldwide in an effort to ameliorate the consequences of this disease. To date, clinical islet transplantation has established improved success with insulin independence rates up to 5 years post-transplant with minimal complications. In spite of marked clinical success, donor availability and selection, engraftment, and side effects of immunosuppression remain as existing obstacles to be addressed to further improve this therapy. Clinical trials to improve engraftment, the availability of insulin-producing cell sources, as well as alternative transplant sites are currently under investigation to expand treatment. With ongoing experimental and clinical studies, islet transplantation continues to be an exciting and attractive therapy to treat type I diabetes mellitus with the prospect of shifting from a treatment for some to a cure for all. PMID:25018643

Comparing and contrasting 'innovation platforms' with other forms of professional networks for strengthening primary healthcare systems for Indigenous Australians.

PubMed

Bailie, Jodie; Cunningham, Frances Clare; Bainbridge, Roxanne Gwendalyn; Passey, Megan E; Laycock, Alison Frances; Bailie, Ross Stewart; Larkins, Sarah L; Brands, Jenny S M; Ramanathan, Shanthi; Abimbola, Seye; Peiris, David

2018-01-01

Efforts to strengthen health systems require the engagement of diverse, multidisciplinary stakeholder networks. Networks provide a forum for experimentation and knowledge creation, information exchange and the spread of good ideas and practice. They might be useful in addressing complex issues or 'wicked' problems, the solutions to which go beyond the control and scope of any one agency. Innovation platforms are proposed as a novel type of network because of their diverse stakeholder composition and focus on problem solving within complex systems. Thus, they have potential applicability to health systems strengthening initiatives, even though they have been predominantly applied in the international agricultural development sector. In this paper, we compare and contrast the concept of innovation platforms with other types of networks that can be used in efforts to strengthen primary healthcare systems, such as communities of practice, practice-based research networks and quality improvement collaboratives. We reflect on our ongoing research programme that applies innovation platform concepts to drive large-scale quality improvement in primary healthcare for Aboriginal and Torres Strait Islander Australians and outline our plans for evaluation. Lessons from our experience will find resonance with others working on similar initiatives in global health.

Quantum simulations and many-body physics with light.

PubMed

Noh, Changsuk; Angelakis, Dimitris G

2017-01-01

In this review we discuss the works in the area of quantum simulation and many-body physics with light, from the early proposals on equilibrium models to the more recent works in driven dissipative platforms. We start by describing the founding works on Jaynes-Cummings-Hubbard model and the corresponding photon-blockade induced Mott transitions and continue by discussing the proposals to simulate effective spin models and fractional quantum Hall states in coupled resonator arrays (CRAs). We also analyse the recent efforts to study out-of-equilibrium many-body effects using driven CRAs, including the predictions for photon fermionisation and crystallisation in driven rings of CRAs as well as other dynamical and transient phenomena. We try to summarise some of the relatively recent results predicting exotic phases such as super-solidity and Majorana like modes and then shift our attention to developments involving 1D nonlinear slow light setups. There the simulation of strongly correlated phases characterising Tonks-Girardeau gases, Luttinger liquids, and interacting relativistic fermionic models is described. We review the major theory results and also briefly outline recent developments in ongoing experimental efforts involving different platforms in circuit QED, photonic crystals and nanophotonic fibres interfaced with cold atoms.

Hotel shows health system keys to service excellence.

PubMed

2003-08-01

Ritz-Carlton partnership part of broader program pursuing service excellence. Nearly 600 system leaders will participate in day-long seminars. GE, Harvard serve as strategic partners for ongoing educational efforts.

2-D Circulation Control Airfoil Benchmark Experiments Intended for CFD Code Validation

NASA Technical Reports Server (NTRS)

Englar, Robert J.; Jones, Gregory S.; Allan, Brian G.; Lin, Johb C.

2009-01-01

A current NASA Research Announcement (NRA) project being conducted by Georgia Tech Research Institute (GTRI) personnel and NASA collaborators includes the development of Circulation Control (CC) blown airfoils to improve subsonic aircraft high-lift and cruise performance. The emphasis of this program is the development of CC active flow control concepts for both high-lift augmentation, drag control, and cruise efficiency. A collaboration in this project includes work by NASA research engineers, whereas CFD validation and flow physics experimental research are part of NASA s systematic approach to developing design and optimization tools for CC applications to fixed-wing aircraft. The design space for CESTOL type aircraft is focusing on geometries that depend on advanced flow control technologies that include Circulation Control aerodynamics. The ability to consistently predict advanced aircraft performance requires improvements in design tools to include these advanced concepts. Validation of these tools will be based on experimental methods applied to complex flows that go beyond conventional aircraft modeling techniques. This paper focuses on recent/ongoing benchmark high-lift experiments and CFD efforts intended to provide 2-D CFD validation data sets related to NASA s Cruise Efficient Short Take Off and Landing (CESTOL) study. Both the experimental data and related CFD predictions are discussed.

Experimental realization of gate controlled topological conducting channels in bilayer graphene

NASA Astrophysics Data System (ADS)

Li, J.; McFaul, K. J.; Zern, Z.; Zhu, J.; Wang, K.; Ren, Y. F.; Qiao, Z. H.; Watanabe, K.; Taniguchi, T.

Manipulating the valley degree of freedom in two-dimensional honeycomb lattices can potentially lead to a new type of electronics called valleytronics. In electrically gapped bilayer graphene, the broken inversion symmetry leads to non-zero and asymmetric Berry curvature Ω in the K and K' valleys of the Brillouin zone. Reversing the sign of Ω at the internal line junction of two oppositely gated bilayer graphene is predicted to yield counter-propagating edge modes, the so-called kink states, with quantized conductance of 4e2 / h in the absence of valley mixing. We have overcome fabrication challenges to implement high-quality hBN encapsulated, dual-split-gates structures necessary to observe the kink states. Here I present experimental evidences of the kink states. In the absence of a magnetic field, the kink states have a mean free path of a few hundred nm. Ballistic conductance of 4e2 / h is achieved in a perpendicular magnetic field. We discuss the potential valley-mixing mechanisms and the role of the magnetic field. Experimental results are supported by numerical studies. We will also discuss ongoing efforts in realizing valley-controlled transmission and guiding of the kink states, which is a significant step towards the development of valleytronics.

Experimental Measurements of the Secondary Electron Yield in the Experimental Measurement of the Secondary Electron Yield in the PEP-II Particle Accelerator Beam Line

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pivi, M.T.F.; Collet, G.; King, F.

Beam instability caused by the electron cloud has been observed in positron and proton storage rings and it is expected to be a limiting factor in the performance of the positron Damping Ring (DR) of future Linear Colliders (LC) such as ILC and CLIC. To test a series of promising possible electron cloud mitigation techniques as surface coatings and grooves, in the Positron Low Energy Ring (LER) of the PEP-II accelerator, we have installed several test vacuum chambers including (i) a special chamber to monitor the variation of the secondary electron yield of technical surface materials and coatings under themore » effect of ion, electron and photon conditioning in situ in the beam line; (ii) chambers with grooves in a straight magnetic-free section; and (iii) coated chambers in a dedicated newly installed 4-magnet chicane to study mitigations in a magnetic field region. In this paper, we describe the ongoing R&D effort to mitigate the electron cloud effect for the LC damping ring, focusing on the first experimental area and on results of the reduction of the secondary electron yield due to in situ conditioning.« less

Dynamic Shock Response of an S2 Glass/SC15 Epoxy Woven Fabric Composite Material System

NASA Astrophysics Data System (ADS)

Key, Christopher; Alexander, Scott; Harstad, Eric; Schumacher, Shane

2017-06-01

The use of S2 glass/SC15 epoxy woven fabric composite materials for blast and ballistic protection has been an area of on-going research over the past decade. In order to accurately model this material system within potential applications under extreme loading conditions, a well characterized and well understood anisotropic equation of state (EOS) is needed. This work details both an experimental program and associated analytical modelling efforts which aim to provide better physical understanding of the anisotropic EOS behavior of this material. Experimental testing focused on planar shock impact tests loading the composite to peak pressures of 15 GPa in both the through-thickness and on-fiber orientation. Test results highlighted the anisotropic response of the material and provided a basis by which the associated numeric micromechanical investigation was compared. Results of the combined experimental and numerical modelling investigation provided insights into not only the constituent material influence on the composite response but also the importance of the geometrical configuration of the plain weave microstructure and the stochastic significance of the microstructural configuration. Sandia National Laboratories is a multi-mission laboratory operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin company, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

Adaptive restoration of river terrace vegetation through iterative experiments

USGS Publications Warehouse

Dela Cruz, Michelle P.; Beauchamp, Vanessa B.; Shafroth, Patrick B.; Decker, Cheryl E.; O’Neil, Aviva

2014-01-01

Restoration projects can involve a high degree of uncertainty and risk, which can ultimately result in failure. An adaptive restoration approach can reduce uncertainty through controlled, replicated experiments designed to test specific hypotheses and alternative management approaches. Key components of adaptive restoration include willingness of project managers to accept the risk inherent in experimentation, interest of researchers, availability of funding for experimentation and monitoring, and ability to restore sites as iterative experiments where results from early efforts can inform the design of later phases. This paper highlights an ongoing adaptive restoration project at Zion National Park (ZNP), aimed at reducing the cover of exotic annual Bromus on riparian terraces, and revegetating these areas with native plant species. Rather than using a trial-and-error approach, ZNP staff partnered with academic, government, and private-sector collaborators to conduct small-scale experiments to explicitly address uncertainties concerning biomass removal of annual bromes, herbicide application rates and timing, and effective seeding methods for native species. Adaptive restoration has succeeded at ZNP because managers accept the risk inherent in experimentation and ZNP personnel are committed to continue these projects over a several-year period. Techniques that result in exotic annual Bromus removal and restoration of native plant species at ZNP can be used as a starting point for adaptive restoration projects elsewhere in the region.

Crash Modification Factors Needs Assessment Workshop

DOT National Transportation Integrated Search

2015-03-01

The Federal Highway Administration (FHWA) hosted a Crash Modification Factor (CMF) Stakeholder Meeting to provide a forum for CMF stakeholders to communicate ongoing efforts and identify opportunities for future collaboration. CMF stakeholders repres...

Coast Guard Polar Icebreaker Modernization: Background and Issues for Congress

DTIC Science & Technology

2013-04-25

Accountability Office, Coast Guard[:]Efforts to Identify Arctic Requirements Are Ongoing, but More Communication about Agency Planning Efforts Would...control, and communications capabilities. The flexibility and mobility of polar icebreakers would assist the Coast Guard in closing future mission...Sea to prevent foreign fishing in U.S. waters and overfishing —Capability to conduct search and rescue in Beaufort Sea for cruise line and natural

Coast Guard Polar Icebreaker Modernization: Background and Issues for Congress

DTIC Science & Technology

2014-02-11

Efforts to Identify Arctic Requirements Are Ongoing, but More Communication about Agency Planning Efforts Would Be Beneficial, GAO-10- 870, September...icebreakers also have substantial command, control, and communications capabilities. The flexibility and mobility of polar icebreakers would assist...Fisheries enforcement in Bering Sea to prevent foreign fishing in U.S. waters and overfishing —Capability to conduct search and rescue in Beaufort Sea

Te Reo Maori as a Subject: The Impact of Language Ideology, Language Practice, and Language Management on Secondary School Students' Decision Making

ERIC Educational Resources Information Center

Jeurissen, Maree

2014-01-01

Te reo Maori, the Indigenous language of Aotearoa (New Zealand), remains 'endangered' despite concentrated ongoing efforts to reverse declining numbers of speakers. Most of these efforts have focused on te reo Maori immersion education settings as these were considered the most effective means to ensure the survival of the language (May &…

Transformation and Decolonisation of Mathematics Education for Sustainable Development: A Case Study of Its Learning Trend in Nigeria

ERIC Educational Resources Information Center

Salami, I. A.; Okeke, C. I. O.

2017-01-01

The quest to contextualise education in Africa has been on-going for a while and many countries have been making efforts towards it. During this time of educational review, conscious efforts should be made to identify problematic levels of some subjects that are dreadful to the learners to pave the way for curriculum re-design for context…

Discovery of Emerging Per-and Polyfluoroalkyl Substances

EPA Science Inventory

Legacy perfluorinated compounds exhibit significant environmental persistence and bioaccumulation potential, which has spawned an ongoing effort to introduce replacement compounds with reduced toxicological risk profiles. Many of these emerging chemical species lack validated qua...

University Transportation Center : administration manual.

DOT National Transportation Integrated Search

2013-01-01

University Transportation Centers (UTCs) were established by the U.S. Department of : Transportation (USDOT) in 1987. UTCs are part of an on-going federal government effort to : improve transportation research, transportation education and to stre...

Superfund Program Review

EPA Pesticide Factsheets

This document presents outcomes of implementing a number of the actions described in the November 2013 Superfund Remedial Program Review (SPR) Action Plan . It also describes ongoing Action Plan efforts and projects future outcomes anticipated in FY 2015

Bio-engineering for land stabilization : final report.

DOT National Transportation Integrated Search

2010-06-01

As part of the Ohio Department of Transportations (ODOTs) ongoing effort to solve engineering problems for the Ohio : transportation system through research, The Ohio State University has undertaken a study entitled Bioengineering for : Land...

FY 1998-2002 proposed airport improvement program

DOT National Transportation Integrated Search

1997-05-01

For Fiscal Years 1998 through 2002, the Illinois Department of Transportation's : Airport Improvement Program includes ongoing efforts to resolve the aircraft : congestion problems in both the Chicago and St. Louis metropolitan areas. In : addition, ...

Equality in Healthcare: The Formation and Ongoing Legacy of an LGBT Advisory Council.

PubMed

Rosa, William; Fullerton, Chelsea; Keller, Ronald

2015-12-01

This article provides a broad overview of the literature on lesbian, gay, bisexual, transgender (LGBT) health disparities and workplace discrimination, as well as the context that led to the formation of an institutional LGBT Advisory Council. The Council was developed in order to demonstrate our ongoing commitment to LGBT inclusion and to improve the lived experiences for both LGBT patients and staff. A retrospective approach is utilized to explore the LGBT Advisory Council's journey to spearhead advocacy efforts at our institution. The Council's accomplishments include taking a leadership role in obtaining nationally recognized designations such as the Healthcare Equality Index and the Magnet Exemplar for Cultural Sensitivity, as well as adding sexual orientation, gender identity, and gender expression fields to our institution's electronic medical record system. Additionally, the Council guides and promotes ongoing house-wide cultural sensitivity staff training efforts. Most recently, the Council marched as a contingency in the world's largest Pride March for the first time in institutional history. It is our hope that our Council will become an inspiration and exemplar for similar groups to form at healthcare institutions and organizations across the nation. Allowing LGBT members of each individual healthcare community the agency to determine the direction of advocacy efforts is incredibly important; however, this must be coupled with an organizational commitment on behalf of leadership to follow through on these initiatives and to provide them with the resources they need in order to be successful.

Assessment of the U.S. Department of Defense Efforts to Develop an Effective Medical Logistics System within the Afghan National Security Forces

DTIC Science & Technology

2011-06-14

aggressively to strengthen measures aimed at ensuring a successful ANSF transition. Ongoing actions include: • Working with CURE International and the ANSF...sustainability include the following ongoing actions: • Working with CURE International and the MoD and MoI to complete, promulgate and implement Standards of Care...approximately June-August 2011. In addition, NTM-A/CSTC-A previously awarded an approximately $1.57M contract with the NGO CURE International to

ASRS Reports on Wake Vortex Encounters

NASA Technical Reports Server (NTRS)

Connell, Linda J.; Taube, Elisa Ann; Drew, Charles Robert; Barclay, Tommy Earl

2010-01-01

ASRS is conducting a structured callback research project of wake vortex incidents reported to the ASRS at all US airports, as well as wake encounters in the enroute environment. This study has three objectives: (1) Utilize the established ASRS supplemental data collection methodology and provide ongoing analysis of wake vortex encounter reports; (2) Document event dynamics and contributing factors underlying wake vortex encounter events; and (3) Support ongoing FAA efforts to address pre-emptive wake vortex risk reduction by utilizing ASRS reporting contributions.

The Architecture and Application of RAMSES, a CCSDS and ECSS PUS Compliant Test and Control System

NASA Astrophysics Data System (ADS)

Battelino, Milan; Svard, Christian; Carlsson, Anna; Carlstedt-Duke, Theresa; Tornqvist, Marcus

2010-08-01

SSC, Swedish Space Corporation, has more than 30 years of experience in developing test and control systems for sounding rockets, experimental test modules and satellites. The increasing amount of ongoing projects made SSC to consider developing a test and control system conformant to CCSDS (Consultative Committee for Space Data Systems) and ECSS (European Cooperation for Space Standardization), that with small effort and cost, could be reused between separate projects and products. The foreseen reduction in cost and development time for different future space-related projects made such a reusable control system desirable. This paper will describe the ideas behind the RAMSES (Rocket and Multi-Satellite EMCS Software) system, its architecture and how it has been and is being used in a variety of applications at SSC such as the multi-satellite mission PRISMA and sounding rocket project MAXUS-8.

Breakdown of Universality for Unequal-Mass Fermi Gases with Infinite Scattering Length

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blume, D.; Daily, K. M.

We treat small trapped unequal-mass two-component Fermi gases at unitarity within a nonperturbative microscopic framework and investigate the system properties as functions of the mass ratio {kappa}, and the numbers N{sub 1} and N{sub 2} of heavy and light fermions. While equal-mass Fermi gases with infinitely large interspecies s-wave scattering length a{sub s} are universal, we find that unequal-mass Fermi gases are, for sufficiently large {kappa} and in the regime where Efimov physics is absent, not universal. In particular, the (N{sub 1},N{sub 2})=(2,1) and (3, 1) systems exhibit three-body and four-body resonances at {kappa}=12.314(2) and 10.4(2), respectively, as well asmore » surprisingly large finite-range effects. These findings have profound implications for ongoing experimental efforts and quantum simulation proposals that utilize unequal-mass atomic Fermi gases.« less

Explosive Joining for the Mars Sample Return Mission

NASA Technical Reports Server (NTRS)

Bement, Laurence J.; Sanok, Joseph T.

2000-01-01

A unique, small-scale, ribbon explosive joining process is being developed as an option for closing and sealing a metal canister to allow the return of a pristine sample of the Martian surface and atmosphere to Earth. This joining process is accomplished by an explosively driven, high-velocity, angular collision of the metal, which melts and effaces the oxide films from the surfaces to allow valence electron sharing to bond the interface. Significant progress has been made through more than 100 experimental tests to meet the goals of this ongoing developmental effort. The metal of choice, aluminum alloy 6061, has been joined in multiple interface configurations and in complete cylinders. This process can accommodate dust and debris on the surfaces to be joined. It can both create and sever a joint at its midpoint with one explosive input. Finally, an approach has been demonstrated that can capture the back blast from the explosive.

Fully-Coupled Thermo-Electrical Modeling and Simulation of Transition Metal Oxide Memristors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mamaluy, Denis; Gao, Xujiao; Tierney, Brian David

2016-11-01

Transition metal oxide (TMO) memristors have recently attracted special attention from the semiconductor industry and academia. Memristors are one of the strongest candidates to replace flash memory, and possibly DRAM and SRAM in the near future. Moreover, memristors have a high potential to enable beyond-CMOS technology advances in novel architectures for high performance computing (HPC). The utility of memristors has been demonstrated in reprogrammable logic (cross-bar switches), brain-inspired computing and in non-CMOS complementary logic. Indeed, the potential use of memristors as logic devices is especially important considering the inevitable end of CMOS technology scaling that is anticipated by 2025. Inmore » order to aid the on-going Sandia memristor fabrication effort with a memristor design tool and establish a clear physical picture of resistance switching in TMO memristors, we have created and validated with experimental data a simulation tool we name the Memristor Charge Transport (MCT) Simulator.« less

Investigation of the effects of NaOH dopant level on the physical and mechanical properties of carbon/phenolic composite material

NASA Technical Reports Server (NTRS)

Clinton, R. G., Jr.

1985-01-01

The near-catastrophic erosion of the STS-8A solid rocket booster nozzle was the instigating factor in the recent, and on-going, intensive investigation of carbon/phenolic composite materials. Much of this effort has been focused on the effect of sodium contamination on the carbon fibers. It is known that sodium acts as a catalyst in the oxidation of the fibers at elevated temperatures. A study was undertaken to determine what changes were caused by variation in sodium content. Investigations were conducted in three areas: (1) phenolic resin; (2) carbon/phenolic prepreg; and (3) cured laminates. Due to the exploratory nature of the studies, a variety of tests in addition to those normally run in production facilities were considered. The experimental methodologies and results of these experiments are discussed, and recommendations for improving techniques and extending the research program are presented.

Status of Line identifications in the ChandraLETG Spectrum of Procyon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Desai, P; Beiersdorfer, P; Brickhouse, N S

We report on our ongoing efforts to produce a relatively complete set of X-ray emission lines present in the Low Energy Transmission Grating (LETG) spectra of Procyon. In addition to using recently reprocessed HRC-S/LETG spectra of Procyon, we use LETG spectra of Capella, along with recent Electron Bean Ion Trap (EBIT) laboratory data and new Flexible Atomic Code (FAC) calculations to identify the wealth of weaker lines present in the spectrum. Experimental measurements at the EBIT-I and EBIT-II facilities at Livermore of astrophysically abundant elements (Fe VII-Fe X, Lepson et al. 2002, Ar IX-Ar XVI, Lepson et al 2003, Smore » VII, S XIV, Lepson et al 2004) and new FAC calculations of Mg and Ne (Gu, 2008 in press) provide an opportunity to identify many of the previously unassigned lines in Procyon (Raassen et al, 2002).« less

Solar Thermal Propulsion Optical Figure Measuring and Rocket Engine Testing

NASA Technical Reports Server (NTRS)

Bonometti, Joseph

1997-01-01

Solar thermal propulsion has been an important area of study for four years at the Propulsion Research Center. Significant resources have been devoted to the development of the UAH Solar Thermal Laboratory that provides unique, high temperature, test capabilities. The facility is fully operational and has successfully conducted a series of solar thruster shell experiments. Although presently dedicated to solar thermal propulsion, the facility has application to a variety of material processing, power generation, environmental clean-up, and other fundamental research studies. Additionally, the UAH Physics Department has joined the Center in support of an in-depth experimental investigation on Solar Thermal Upper Stage (STUS) concentrators. Laboratory space has been dedicated to the concentrator evaluation in the UAH Optics Building which includes a vertical light tunnel. Two, on-going, research efforts are being sponsored through NASA MSFC (Shooting Star Flight Experiment) and the McDonnell Douglas Corporation (Solar Thermal Upper Stage Technology Ground Demonstrator).

Mach Probe Measurements in a Large-Scale Helicon Plasma

NASA Astrophysics Data System (ADS)

Hatch, M. W.; Kelly, R. F.; Fisher, D. M.; Gilmore, M.; Dwyer, R. H.

2017-10-01

A new six-tipped Mach probe, that utilizes a fused-quartz insulator, has been developed and initially tested in the HelCat dual-source plasma device at the University of New Mexico. The new design allows for relatively long duration measurements of parallel and perpendicular flows that suffer less from thermal changes in conductivity and surface build-up seen in previous alumina-insulated designs. Mach probe measurement will be presented in comparison with ongoing laser induced fluorescence (LIF) measurements, previous Mach probe measurements, ExB flow estimates derived from Langmuir probes, and fast-frame CCD camera images, in an effort to better understand previous anomalous ion flow in HelCat. Additionally, Mach probe-LIF comparisons will provide an experimentally obtained Mach probe calibration constant, K, to validate sheath-derived estimates for the weakly magnetized case. Supported by U.S. National Science Foundation Award 1500423.

Assessment of Severe Apnoea through Voice Analysis, Automatic Speech, and Speaker Recognition Techniques

NASA Astrophysics Data System (ADS)

Fernández Pozo, Rubén; Blanco Murillo, Jose Luis; Hernández Gómez, Luis; López Gonzalo, Eduardo; Alcázar Ramírez, José; Toledano, Doroteo T.

2009-12-01

This study is part of an ongoing collaborative effort between the medical and the signal processing communities to promote research on applying standard Automatic Speech Recognition (ASR) techniques for the automatic diagnosis of patients with severe obstructive sleep apnoea (OSA). Early detection of severe apnoea cases is important so that patients can receive early treatment. Effective ASR-based detection could dramatically cut medical testing time. Working with a carefully designed speech database of healthy and apnoea subjects, we describe an acoustic search for distinctive apnoea voice characteristics. We also study abnormal nasalization in OSA patients by modelling vowels in nasal and nonnasal phonetic contexts using Gaussian Mixture Model (GMM) pattern recognition on speech spectra. Finally, we present experimental findings regarding the discriminative power of GMMs applied to severe apnoea detection. We have achieved an 81% correct classification rate, which is very promising and underpins the interest in this line of inquiry.

Early Detection of Severe Apnoea through Voice Analysis and Automatic Speaker Recognition Techniques

NASA Astrophysics Data System (ADS)

Fernández, Ruben; Blanco, Jose Luis; Díaz, David; Hernández, Luis A.; López, Eduardo; Alcázar, José

This study is part of an on-going collaborative effort between the medical and the signal processing communities to promote research on applying voice analysis and Automatic Speaker Recognition techniques (ASR) for the automatic diagnosis of patients with severe obstructive sleep apnoea (OSA). Early detection of severe apnoea cases is important so that patients can receive early treatment. Effective ASR-based diagnosis could dramatically cut medical testing time. Working with a carefully designed speech database of healthy and apnoea subjects, we present and discuss the possibilities of using generative Gaussian Mixture Models (GMMs), generally used in ASR systems, to model distinctive apnoea voice characteristics (i.e. abnormal nasalization). Finally, we present experimental findings regarding the discriminative power of speaker recognition techniques applied to severe apnoea detection. We have achieved an 81.25 % correct classification rate, which is very promising and underpins the interest in this line of inquiry.

Nuclear Thermal Rocket Element Environmental Simulator (NTREES) Upgrade Activities

NASA Technical Reports Server (NTRS)

Emrich, William J. Jr.; Moran, Robert P.; Pearson, J. Boise

2012-01-01

To support the on-going nuclear thermal propulsion effort, a state-of-the-art non nuclear experimental test setup has been constructed to evaluate the performance characteristics of candidate fuel element materials and geometries in representative environments. The facility to perform this testing is referred to as the Nuclear Thermal Rocket Element Environment Simulator (NTREES). This device can simulate the environmental conditions (minus the radiation) to which nuclear rocket fuel components will be subjected during reactor operation. Test articles mounted in the simulator are inductively heated in such a manner so as to accurately reproduce the temperatures and heat fluxes which would normally occur as a result of nuclear fission and would be exposed to flowing hydrogen. Initial testing of a somewhat prototypical fuel element has been successfully performed in NTREES and the facility has now been shutdown to allow for an extensive reconfiguration of the facility which will result in a significant upgrade in its capabilities

Fiber lasers and amplifiers for science and exploration at NASA Goddard Space Flight Center

NASA Technical Reports Server (NTRS)

Krainak, Michael A.; Abshire, James; Allan, Graham R.; Stephen Mark

2005-01-01

We discuss present and near-term uses for high-power fiber lasers and amplifiers for NASA- specific applications including planetary topography and atmospheric spectroscopy. Fiber lasers and amplifiers offer numerous advantages for both near-term and future deployment of instruments on exploration and science remote sensing orbiting satellites. Ground-based and airborne systems provide an evolutionary path to space and a means for calibration and verification of space-borne systems. We present experimental progress on both the fiber transmitters and instrument prototypes for ongoing development efforts. These near-infrared instruments are laser sounders and lidars for measuring atmospheric carbon dioxide, oxygen, water vapor and methane and a pseudo-noise (PN) code laser ranging system. The associated fiber transmitters include high-power erbium, ytterbium, neodymium and Raman fiber amplifiers. In addition, we will discuss near-term fiber laser and amplifier requirements and programs for NASA free space optical communications, planetary topography and atmospheric spectroscopy.

Herbivory Network: An international, collaborative effort to study herbivory in Arctic and alpine ecosystems

NASA Astrophysics Data System (ADS)

Barrio, I. C.; Hik, D. S.; Jónsdóttir, I. S.; Bueno, C. G.; Mörsdorf, M. A.; Ravolainen, V. T.

2016-09-01

Plant-herbivore interactions are central to the functioning of tundra ecosystems, but their outcomes vary over space and time. Accurate forecasting of ecosystem responses to ongoing environmental changes requires a better understanding of the processes responsible for this heterogeneity. To effectively address this complexity at a global scale, coordinated research efforts, including multi-site comparisons within and across disciplines, are needed. The Herbivory Network was established as a forum for researchers from Arctic and alpine regions to collaboratively investigate the multifunctional role of herbivores in these changing ecosystems. One of the priorities is to integrate sites, methodologies, and metrics used in previous work, to develop a set of common protocols and design long-term geographically-balanced, coordinated experiments. The implementation of these collaborative research efforts will also improve our understanding of traditional human-managed systems that encompass significant portions of the sub-Arctic and alpine areas worldwide. A deeper understanding of the role of herbivory in these systems under ongoing environmental changes will guide appropriate adaptive strategies to preserve their natural values and related ecosystem services.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Montellano, B.O. de

This report describes later stages of a program to develop culturally relevant science and math programs for Hispanic students. Part of this effort was follow-up with 17 teachers who participated in early stages of the program. Response was not very good. Included with the report is a first draft effort for curriculum materials which could be used as is in such a teaching effort. Several of the participating teachers were invited to a writing workshop, where lesson plans were drafted, and critiqued and following rework are listed in this publication. Further work needs to be completed and is ongoing.

METAL PARTITIONING IN COMBUSTION PROCESSES

EPA Science Inventory

This article summarizes ongoing research efforts at the National Risk Management Research Laboratory of the U.S. Environmental Protection Agency examining [high temperature] metal behavior within combustion environments. The partitioning of non-volatile (Cr and Ni), semi-volatil...

Low-cost, distributed, sensor-based weigh-in-motion systems.

DOT National Transportation Integrated Search

2009-12-01

Monitoring truck weights is essential for traffic operations, roadway design, traffic safety, and regulations. : Traditional roadside static truck weighing stations have many operational shortcomings, and so there have : been ongoing efforts to devel...

Maritime trade & transportation 2007

DOT National Transportation Integrated Search

2005-01-10

This latest edition of Maritime Trade and Transportation follows two prior reports released in 1999 and 2002. These reports refl ect an ongoing effort by the Maritime Data Working Group to provide quality, timely, comprehensive, and relevant maritime...

Continued improvements at one C3RS site

DOT National Transportation Integrated Search

2015-06-01

Human-factors-based solutions, along with process and technology innovations, can make significant contributions to improving safety in the railroad industry. As part of ongoing efforts to address human-factors, FRA implemented the Confidential Close...

PFCA Article Testing

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) has established an ongoing effort to quantify possible changes in levels of perfluorinated chemicals (PFCs) in articles of commerce (AOCs). Temporal trends in the concentrations of selected PFCs, including perfluorooctanoic acid (PFO...

United States Army Medical Materiel Development Activity - 1989

DTIC Science & Technology

1990-01-31

physicians to treat diseases such as Korean Hemorrhagic Fever and Lassa Fever. * J-5 Human Monoclonal Antibody is secreted by cultured hybridomas that were...volunteer studies involving a collaborative effort between WRAIR and the Swiss Serum and Vaccine Institute (SSVI). s Lassa Fever Immune Plasma is an...immune globulin used to treat Lassa fever infections. The collection of human immune plasma in Africa is an ongoing contract effort. USANRIID performs

On solid ground. Revenue gains continue to outpace growth in expenses, allowing U.S. hospitals to enjoy record profit and margin.

PubMed

Evans, Melanie

2007-10-29

Hospitals enjoyed a surge in profits last year, reporting an aggregate profit margin of 6%. Executives at financially strong systems credit long-term efforts to improve performance for the results. Elizabeth Concordia, left, of the University of Pittsburgh Medical Center system, says its efforts stressed ongoing consolidation and integration to wipe out waste and errors.

KENNEDY SPACE CENTER, FLA. - In the RLV Hangar, Adm. Harold Gehman, chairman of the Columbia Investigation Accident Board, points to data on a chart. He and other board members are visiting as part of the ongoing investigation. Recovery efforts as of May 5 included 82,500 pieces of debris weighing 84,800 pounds, almost 40 percent of the total dry weight of the shuttle. About 25,000 personnel took part, utilizing almost 1.5 million total man-hours in the recovery effort and involving more than 130 federal, state and local agencies. The operation was also supported by more than 270 organizations that included businesses and volunteer groups.

NASA Image and Video Library

2003-05-15

KENNEDY SPACE CENTER, FLA. - In the RLV Hangar, Adm. Harold Gehman, chairman of the Columbia Investigation Accident Board, points to data on a chart. He and other board members are visiting as part of the ongoing investigation. Recovery efforts as of May 5 included 82,500 pieces of debris weighing 84,800 pounds, almost 40 percent of the total dry weight of the shuttle. About 25,000 personnel took part, utilizing almost 1.5 million total man-hours in the recovery effort and involving more than 130 federal, state and local agencies. The operation was also supported by more than 270 organizations that included businesses and volunteer groups.

KENNEDY SPACE CENTER, FLA. - Adm. Harold Gehman, far left, chairman of the Columbia Investigation Accident Board, looks at pieces of Columbia debris collected in the KSC RLV Hangar. Other members of the board accompanied him as part of the ongoing investigation. Recovery efforts as of May 5 included 82,500 pieces of debris weighing 84,800 pounds, almost 40 percent of the total dry weight of the shuttle. About 25,000 personnel took part, utilizing almost 1.5 million total man-hours in the recovery effort and involving more than 130 federal, state and local agencies. The operation was also supported by more than 270 organizations that included businesses and volunteer groups.

NASA Image and Video Library

2003-05-15

KENNEDY SPACE CENTER, FLA. - Adm. Harold Gehman, far left, chairman of the Columbia Investigation Accident Board, looks at pieces of Columbia debris collected in the KSC RLV Hangar. Other members of the board accompanied him as part of the ongoing investigation. Recovery efforts as of May 5 included 82,500 pieces of debris weighing 84,800 pounds, almost 40 percent of the total dry weight of the shuttle. About 25,000 personnel took part, utilizing almost 1.5 million total man-hours in the recovery effort and involving more than 130 federal, state and local agencies. The operation was also supported by more than 270 organizations that included businesses and volunteer groups.

Reconstruction and Validation of a Genome-Scale Metabolic Model for the Filamentous Fungus Neurospora crassa Using FARM

PubMed Central

Hood, Heather M.; Ocasio, Linda R.; Sachs, Matthew S.; Galagan, James E.

2013-01-01

The filamentous fungus Neurospora crassa played a central role in the development of twentieth-century genetics, biochemistry and molecular biology, and continues to serve as a model organism for eukaryotic biology. Here, we have reconstructed a genome-scale model of its metabolism. This model consists of 836 metabolic genes, 257 pathways, 6 cellular compartments, and is supported by extensive manual curation of 491 literature citations. To aid our reconstruction, we developed three optimization-based algorithms, which together comprise Fast Automated Reconstruction of Metabolism (FARM). These algorithms are: LInear MEtabolite Dilution Flux Balance Analysis (limed-FBA), which predicts flux while linearly accounting for metabolite dilution; One-step functional Pruning (OnePrune), which removes blocked reactions with a single compact linear program; and Consistent Reproduction Of growth/no-growth Phenotype (CROP), which reconciles differences between in silico and experimental gene essentiality faster than previous approaches. Against an independent test set of more than 300 essential/non-essential genes that were not used to train the model, the model displays 93% sensitivity and specificity. We also used the model to simulate the biochemical genetics experiments originally performed on Neurospora by comprehensively predicting nutrient rescue of essential genes and synthetic lethal interactions, and we provide detailed pathway-based mechanistic explanations of our predictions. Our model provides a reliable computational framework for the integration and interpretation of ongoing experimental efforts in Neurospora, and we anticipate that our methods will substantially reduce the manual effort required to develop high-quality genome-scale metabolic models for other organisms. PMID:23935467

An Overview of the Launch Vehicle Blast Environments Development Efforts

NASA Technical Reports Server (NTRS)

Richardson, Erin; Bangham, Mike; Blackwood, James; Skinner, Troy; Hays, Michael; Jackson, Austin; Richman, Ben

2014-01-01

NASA has been funding an ongoing development program to characterize the explosive environments produced during a catastrophic launch vehicle accident. These studies and small-scale tests are focused on the near field environments that threaten the crew. The results indicate that these environments are unlikely to result in immediate destruction of the crew modules. The effort began as an independent assessment by NASA safety organizations, followed by the Ares program and NASA Engineering and Safety Center and now as a Space Launch Systems (SLS) focused effort. The development effort is using the test and accident data available from public or NASA sources as well as focused scaled tests that are examining the fundamental aspects of uncontained explosions of Hydrogen and air and Hydrogen and Oxygen. The primary risk to the crew appears to be the high-energy fragments and these are being characterized for the SLS. The development efforts will characterize the thermal environment of the explosions as well to ensure that the risk is well understood and to document the overall energy balance of an explosion. The effort is multi-path in that analytical, computational and focused testing is being used to develop the knowledge to understand potential SLS explosions. This is an ongoing program with plans that expand the development from fundamental testing at small-scale levels to large-scale tests that can be used to validate models for commercial programs. The ultimate goal is to develop a knowledge base that can be used by vehicle designers to maximize crew survival in an explosion.

77 FR 66609 - Notice of FERC Staff Attendance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-06

... El Paso Electric Company ER13-91-000 Black Hills Power, Inc., et al......... ER13-96-000 Black Hills... ongoing outreach efforts. The meeting may discuss matters at issue in the above captioned dockets. For...

78 FR 16497 - Notice of FERC Staff Attendance

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-15

... Electric Company ER13-91-000 Black Hills Power, Inc., et al ER13-96-000 Black Hills Colorado Electric... of the Commission's ongoing outreach efforts. The meeting may discuss matters at issue in the above...

77 FR 74844 - Notice of FERC Staff Attendance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-18

............ Docket No. ER13-91-000. Black Hills Power, Inc., et al... Docket No. ER13-96-000. Black Hills Colorado... Commission's ongoing outreach efforts. The meeting may discuss matters at issue in the above captioned...

Climate change : observations on federal efforts to adapt to a changing climate

DOT National Transportation Integrated Search

2009-03-25

Based on preliminary observations from GAOs ongoing adaptation work for the Select Committee on Energy Independence and Global Warming, certain federal, state, local, and international government authorities are beginning to consider and implement...

EPA Office of Research and Development Green Infrastructure Research

EPA Science Inventory

This presentation provides an overview introduction to the USEPA Office of Research and Development (ORD)'s ongoing green infrastructure (GI) research efforts for stormwater management. GI approaches that increase infiltration, evapotranspiration, and rainwater harvesting offer ...

Mouse Sperm Cryopreservation Using Cryoprotectant Containing l-Glutamine.

PubMed

Takeo, Toru; Nakagata, Naomi

2018-06-01

Efforts to advance sperm cryopreservation are ongoing and include modifications in the cryoprotective agents. The addition of l-glutamine maintains post-thaw motility and reduces plasma membrane damage to sperm. © 2018 Cold Spring Harbor Laboratory Press.

Community Update on Site Activities, July 19, 2013

EPA Pesticide Factsheets

In an effort to engage and inform community members interested in the New Bedford Harbor Superfund Site cleanup, EPA will be issuing periodic topic-based fact sheets that will provide background information and updates about ongoing activities.

Drugs and highway safety 1980

DOT National Transportation Integrated Search

1980-05-01

This report presents findings of a study to describe (1) present knowledge about the relationship between drug use by drivers and highway safety, and (2) efforts to detect and prevent drug-impaired driving. Past, ongoing, and planned activities at fe...

Scientific Basis for Biotech Crops

EPA Science Inventory

Efforts to change the genetic makeup of plants have been ongoing since the beginning of agriculture, thousands of years ago. Early plant improvements relied on simply cross-breeding cultivars with desired traits. Advancements in mutation breeding through chemicals and radiation ...

Alternative methods for developing external travel survey data.

DOT National Transportation Integrated Search

2010-10-01

The Texas Department of Transportation (TxDOT) has a comprehensive on-going travel survey : program that supports the travel demand models being developed for transportation planning efforts in urban : areas throughout Texas. One component of the sur...

DOT's Restructuring - Limited Progress in Streamlining Field Office Structure

DOT National Transportation Integrated Search

1998-04-30

The report characterizes two ongoing efforts in the Department involving our : analysis of opportunities to collocate field offices on an intermodal basis, and : FHWA's examination of its regional office structure. Although many aspects of : our effo...

78 FR 2445 - Notice of Intent To Renew the Advisory Committee on Apprenticeship (ACA) Charter

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-11

... and partners for its ongoing operational effectiveness. Apart from the ACA, there is no single..., veterans, women, minorities and other under-utilized and disadvantaged populations; and (5) efforts to...

Placebo effect in clinical trial design for irritable bowel syndrome.

PubMed

Shah, Eric; Pimentel, Mark

2014-04-30

Ongoing efforts to improve clinical trial design in irritable bowel syndrome have been hindered by high placebo response rates and ineffective outcome measures. We assessed established strategies to minimize placebo effect as well as the various ap-proaches to placebo effect which can affect trial design. These include genetic markers such as catechol-O-methyltransferase, opioidergic and dopaminergic neurobiologic theory, pre-cebo effect centered on expectancy theory, and side effect unblinding grounded on conditioning theory. We reviewed endpoints used in the study of IBS over the past decade including adequate relief and subjective global relief, emphasizing their weaknesses in fully evaluating the IBS condition, specifically their motility effects based on functional net value and relative benefit-harm based on dropouts due to adverse events. The focus of this review is to highlight ongoing efforts to improve clinical trial design which can lead to better outcomes in a real-world setting.

Increasing Racial/Ethnic Diversity in Nursing to Reduce Health Disparities and Achieve Health Equity

PubMed Central

Malone, Beverly

2014-01-01

As nursing continues to advance health care in the 21st century, the current shift in demographics, coupled with the ongoing disparities in health care and health outcomes, will warrant our ongoing attention and action. As within all health professions, concerted efforts are needed to diversify the nation's health-care workforce. The nursing profession in particular will be challenged to recruit and retain a culturally diverse workforce that mirrors the nation's change in demographics. This increased need to enhance diversity in nursing is not new to the profession; however, the need to successfully address this issue has never been greater. This article discusses increasing the diversity in nursing and its importance in reducing health disparities. We highlight characteristics of successful recruitment and retention efforts targeting racial/ethnic minority nurses and conclude with recommendations to strengthen the development and evaluation of their contributions to eliminating health disparities. PMID:24385664

Redox chemistry and natural organic matter (NOM): Geochemists' dream, analytical chemists' nightmare

USGS Publications Warehouse

Macalady, Donald L.; Walton-Day, Katherine

2011-01-01

Natural organic matter (NOM) is an inherently complex mixture of polyfunctional organic molecules. Because of their universality and chemical reversibility, oxidation/reductions (redox) reactions of NOM have an especially interesting and important role in geochemistry. Variabilities in NOM composition and chemistry make studies of its redox chemistry particularly challenging, and details of NOM-mediated redox reactions are only partially understood. This is in large part due to the analytical difficulties associated with NOM characterization and the wide range of reagents and experimental systems used to study NOM redox reactions. This chapter provides a summary of the ongoing efforts to provide a coherent comprehension of aqueous redox chemistry involving NOM and of techniques for chemical characterization of NOM. It also describes some attempts to confirm the roles of different structural moieties in redox reactions. In addition, we discuss some of the operational parameters used to describe NOM redox capacities and redox states, and describe nomenclature of NOM redox chemistry. Several relatively facile experimental methods applicable to predictions of the NOM redox activity and redox states of NOM samples are discussed, with special attention to the proposed use of fluorescence spectroscopy to predict relevant redox characteristics of NOM samples.

Kinetic physics in ICF: present understanding and future directions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rinderknecht, Hans G.; Amendt, P. A.; Wilks, S. C.

Kinetic physics has the potential to impact the performance of indirect-drive inertial confinement fusion (ICF) experiments. Systematic anomalies in the National Ignition Facility implosion dataset have been identified in which kinetic physics may play a role, including inferred missing energy in the hohlraum, drive asymmetry in near-vacuum hohlraums, low areal density and high burn-averaged ion temperatures (T i ) compared with mainline simulations, and low ratios of the DD-neutron and DT-neutron yields and inferred T i . Several components of ICF implosions are likely to be influenced or dominated by kinetic physics: laser-plasma interactions in the LEH and hohlraum interior;more » the hohlraum wall blowoff, blowoff/gas and blowoff/ablator interfaces; the ablator and ablator/ice interface; and the DT fuel all present conditions in which kinetic physics can significantly affect the dynamics. This review presents the assembled experimental data and simulation results to date, which indicate that the effects of long mean-free-path plasma phenomena and self-generated electromagnetic fields may have a significant impact in ICF targets. Finally, simulation and experimental efforts are proposed to definitively quantify the importance of these effects at ignition-relevant conditions, including priorities for ongoing study.« less

Kinetic physics in ICF: present understanding and future directions

DOE PAGES

Rinderknecht, Hans G.; Amendt, P. A.; Wilks, S. C.; ...

2018-03-19

Kinetic physics has the potential to impact the performance of indirect-drive inertial confinement fusion (ICF) experiments. Systematic anomalies in the National Ignition Facility implosion dataset have been identified in which kinetic physics may play a role, including inferred missing energy in the hohlraum, drive asymmetry in near-vacuum hohlraums, low areal density and high burn-averaged ion temperatures (T i ) compared with mainline simulations, and low ratios of the DD-neutron and DT-neutron yields and inferred T i . Several components of ICF implosions are likely to be influenced or dominated by kinetic physics: laser-plasma interactions in the LEH and hohlraum interior;more » the hohlraum wall blowoff, blowoff/gas and blowoff/ablator interfaces; the ablator and ablator/ice interface; and the DT fuel all present conditions in which kinetic physics can significantly affect the dynamics. This review presents the assembled experimental data and simulation results to date, which indicate that the effects of long mean-free-path plasma phenomena and self-generated electromagnetic fields may have a significant impact in ICF targets. Finally, simulation and experimental efforts are proposed to definitively quantify the importance of these effects at ignition-relevant conditions, including priorities for ongoing study.« less

Kinetic physics in ICF: present understanding and future directions

NASA Astrophysics Data System (ADS)

Rinderknecht, Hans G.; Amendt, P. A.; Wilks, S. C.; Collins, G.

2018-06-01

Kinetic physics has the potential to impact the performance of indirect-drive inertial confinement fusion (ICF) experiments. Systematic anomalies in the National Ignition Facility implosion dataset have been identified in which kinetic physics may play a role, including inferred missing energy in the hohlraum, drive asymmetry in near-vacuum hohlraums, low areal density and high burn-averaged ion temperatures (〈Ti 〉) compared with mainline simulations, and low ratios of the DD-neutron and DT-neutron yields and inferred 〈Ti 〉. Several components of ICF implosions are likely to be influenced or dominated by kinetic physics: laser-plasma interactions in the LEH and hohlraum interior; the hohlraum wall blowoff, blowoff/gas and blowoff/ablator interfaces; the ablator and ablator/ice interface; and the DT fuel all present conditions in which kinetic physics can significantly affect the dynamics. This review presents the assembled experimental data and simulation results to date, which indicate that the effects of long mean-free-path plasma phenomena and self-generated electromagnetic fields may have a significant impact in ICF targets. Simulation and experimental efforts are proposed to definitively quantify the importance of these effects at ignition-relevant conditions, including priorities for ongoing study.

Benchmark studies of thermal jet mixing in SFRs using a two-jet model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Omotowa, O. A.; Skifton, R.; Tokuhiro, A.

To guide the modeling, simulations and design of Sodium Fast Reactors (SFRs), we explore and compare the predictive capabilities of two numerical solvers COMSOL and OpenFOAM in the thermal jet mixing of two buoyant jets typical of the outlet flow from a SFR tube bundle. This process will help optimize on-going experimental efforts at obtaining high resolution data for V and V of CFD codes as anticipated in next generation nuclear systems. Using the k-{epsilon} turbulence models of both codes as reference, their ability to simulate the turbulence behavior in similar environments was first validated for single jet experimental datamore » reported in literature. This study investigates the thermal mixing of two parallel jets having a temperature difference (hot-to-cold) {Delta}T{sub hc}= 5 deg. C, 10 deg. C and velocity ratios U{sub c}/U{sub h} = 0.5, 1. Results of the computed turbulent quantities due to convective mixing and the variations in flow field along the axial position are presented. In addition, this study also evaluates the effect of spacing ratio between jets in predicting the flow field and jet behavior in near and far fields. (authors)« less

Recent Advances and Future Prospects in Fundamental Symmetries

NASA Astrophysics Data System (ADS)

Plaster, Brad

2017-09-01

A broad program of initiatives in fundamental symmetries seeks answers to several of the most pressing open questions in nuclear physics, ranging from the scale of the neutrino mass, to the particle-antiparticle nature of the neutrino, to the origin of the matter-antimatter asymmetry, to the limits of Standard Model interactions. Although the experimental program is quite broad, with efforts ranging from precision measurements of neutrino properties; to searches for electric dipole moments; to precision measurements of magnetic dipole moments; and to precision measurements of couplings, particle properties, and decays; all of these seemingly disparate initiatives are unified by several common threads. These include the use and exploitation of symmetry principles, novel cross-disciplinary experimental work at the forefront of the precision frontier, and the need for accompanying breakthroughs in development of the theory necessary for an interpretation of the anticipated results from these experiments. This talk will highlight recent accomplishments and advances in fundamental symmetries and point to the extraordinary level of ongoing activity aimed at realizing the development and interpretation of next-generation experiments. This material is based upon work supported by the U.S. Department of Energy, Office of Science, Office of Nuclear Physics, under Award Number DE-SC-0014622.

The role of barrier membranes for guided bone regeneration and restoration of large bone defects: current experimental and clinical evidence

PubMed Central

2012-01-01

Treatment of large bone defects represents a great challenge in orthopedic and craniomaxillofacial surgery. Although there are several methods for bone reconstruction, they all have specific indications and limitations. The concept of using barrier membranes for restoration of bone defects has been developed in an effort to simplify their treatment by offering a sinlge-staged procedure. Research on this field of bone regeneration is ongoing, with evidence being mainly attained from preclinical studies. The purpose of this review is to summarize the current experimental and clinical evidence on the use of barrier membranes for restoration of bone defects in maxillofacial and orthopedic surgery. Although there are a few promising preliminary human studies, before clinical applications can be recommended, future research should aim to establish the 'ideal' barrier membrane and delineate the need for additional bone grafting materials aiming to 'mimic' or even accelerate the normal process of bone formation. Reproducible results and long-term observations with barrier membranes in animal studies, and particularly in large animal models, are required as well as well-designed clinical studies to evaluate their safety, efficacy and cost-effectiveness. PMID:22834465

DEFLECTION OF A HETEROGENEOUS WIDE-BEAM UNDER UNIFORM PRESSURE LOAD

DOE Office of Scientific and Technical Information (OSTI.GOV)

T. V. Holschuh; T. K. Howard; W. R. Marcum

2014-07-01

Oregon State University (OSU) and the Idaho National Laboratory (INL) are currently collaborating on a test program which entails hydro-mechanical testing of a generic plate type fuel element, or generic test plate assembly (GTPA), for the purpose of qualitatively demonstrating mechanical integrity of uranium-molybdenum monolithic plates as compared to that of uranium aluminum dispersion, and aluminum fuel plates onset by hydraulic forces. This test program supports ongoing work conducted for/by the Global Threat Reduction Initiative (GTRI) Fuels Development Program. This study’s focus supports the ongoing collaborative effort by detailing the derivation of an analytic solution for deflection of a heterogeneousmore » plate under a uniform, distributed load in order to predict the deflection of test plates in the GTPA. The resulting analytical solutions for three specific boundary condition sets are then presented against several test cases of a homogeneous plate. In all test cases considered, the results for both homogeneous and heterogeneous plates are numerically identical to one another, demonstrating correct derivation of the heterogeneous solution. Two additional problems are presents herein that provide a representative deflection profile for the plates under consideration within the GTPA. Furthermore, qualitative observations are made about the influence of a more-rigid internal fuel-meat region and its influence on the overall deflection profile of a plate. Present work is being directed to experimentally confirm the analytical solution’s results using select materials.« less

Clinical pharmacology of analgesics assessed with human experimental pain models: bridging basic and clinical research

PubMed Central

Oertel, Bruno Georg; Lötsch, Jörn

2013-01-01

The medical impact of pain is such that much effort is being applied to develop novel analgesic drugs directed towards new targets and to investigate the analgesic efficacy of known drugs. Ongoing research requires cost-saving tools to translate basic science knowledge into clinically effective analgesic compounds. In this review we have re-examined the prediction of clinical analgesia by human experimental pain models as a basis for model selection in phase I studies. The overall prediction of analgesic efficacy or failure of a drug correlated well between experimental and clinical settings. However, correct model selection requires more detailed information about which model predicts a particular clinical pain condition. We hypothesized that if an analgesic drug was effective in an experimental pain model and also a specific clinical pain condition, then that model might be predictive for that particular condition and should be selected for development as an analgesic for that condition. The validity of the prediction increases with an increase in the numbers of analgesic drug classes for which this agreement was shown. From available evidence, only five clinical pain conditions were correctly predicted by seven different pain models for at least three different drugs. Most of these models combine a sensitization method. The analysis also identified several models with low impact with respect to their clinical translation. Thus, the presently identified agreements and non-agreements between analgesic effects on experimental and on clinical pain may serve as a solid basis to identify complex sets of human pain models that bridge basic science with clinical pain research. PMID:23082949

Coast Guard: Efforts to Identify Arctic Requirements Are Ongoing, but More Communication about Agency Planning Efforts Would Be Beneficial

DTIC Science & Technology

2010-09-01

involve Indian tribal governments, such as certain Arctic indigenous communities in Alaska , in decisions that affect them.14 Finally, since the Arctic...primarily as vehicles for distributing land and monetary benefits to Alaska Natives to provide a fair and just settlement of aboriginal land claims in... Alaska Native stakeholders, as well as private or nonprofit organizations representing Arctic interests. These observations are not

Waldenstrom Macroglobulinemia☆

PubMed Central

Leleu, Xavier; Roccaro, Aldo M.; Moreau, Anne-Sophie; Dupire, Sophie; Robu, Daniela; Gay, Julie; Hatjiharissi, Evdoxia; Burwik, Nicholas; Ghobrial, Irene M.

2011-01-01

In the past years, new developments have occurred both in the understanding of the biology of Waldenstrom Macroglobulinemia (WM) and in therapeutic options for WM. WM is a B-cell disorder characterized primarily by bone marrow infiltration with lymphoplasmacytic cells, along with demonstration of an IgM monoclonal gammopathy. Despite advances in therapy, WM remains incurable, with 5–6 years median overall survival of patients in symptomatic WM. Therapy is postponed for asymptomatic patients, and progressive anemia is the most common indication for initiation of treatment. The main therapeutic options include alkylating agents, nucleoside analogues, and rituximab. Studies involving combination chemotherapy are ongoing, and preliminary results are encouraging. No specific agent or regimen has been shown to be superior to another for treatment of WM. As such, novel therapeutic agents are needed for the treatment of WM. In ongoing efforts, we and others have sought to exploit advances made in the understanding of the biology of WM so as to better target therapeutics for this malignancy. These efforts have led to the development of several novel agents including the proteasome inhibitor bortezomib, and several Akt/mTor inhibitors, perifosine and Rad001, and immunomodulatory agents such as thalidomide and lenalidomide. Studies with monoclonal antibodies are ongoing and promising including the use of alemtuzumab, SGN-70, and the APRIL/BLYS blocking protein TACI-Ig atacicept. Other agents currently being tested in clinical trials include the PKC inhibitor enzastaurin, the natural product resveratrol, as well as the statin simvastatin. This report provides an update of the current preclinical studies and clinical efforts for the development of novel agents in the treatment of WM. PMID:18555588

Targeting oncogenic vulnerabilities in triple negative breast cancer: biological bases and ongoing clinical studies

PubMed Central

Ocana, Alberto; Pandiella, Atanasio

2017-01-01

Triple negative breast cancer (TNBC) is still an incurable disease despite the great scientific effort performed during the last years. The huge heterogeneity of this disease has motivated the evaluation of a great number of therapies against different molecular alterations. In this article, we review the biological bases of this entity and how the known molecular evidence supports the current preclinical and clinical development of new therapies. Special attention will be given to ongoing clinical studies and potential options for future drug combinations. PMID:28108739

Advances in HIV-1 Vaccine Development

PubMed Central

Gao, Yong

2018-01-01

An efficacious HIV-1 vaccine is regarded as the best way to halt the ongoing HIV-1 epidemic. However, despite significant efforts to develop a safe and effective vaccine, the modestly protective RV144 trial remains the only efficacy trial to provide some level of protection against HIV-1 acquisition. This review will outline the history of HIV vaccine development, novel technologies being applied to HIV vaccinology and immunogen design, as well as the studies that are ongoing to advance our understanding of vaccine-induced immune correlates of protection. PMID:29614779

Snow removal performance metrics : final report.

DOT National Transportation Integrated Search

2017-05-01

This document is the final report for the Clear Roads project entitled Snow Removal Performance Metrics. The project team was led by researchers at Washington State University on behalf of Clear Roads, an ongoing pooled fund research effort focused o...

Determination of Perfluorinated Compounds in the Upper Mississippi River Basin

EPA Science Inventory

Despite ongoing efforts to develop robust analytical methods for the determination of perfluorinated compounds (PFCs) such as perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA) in surface water, comparatively little has been published on method performance, and the...

FTA National Transit GIS : data standards, guidelines and recommended practices

DOT National Transportation Integrated Search

1996-01-01

The Federal Transit Administration (FTA) National Transit Geographic Information System (GIS) is a representative inventory of the public transit assets of the country. Creation of this national system is an ongoing and collaborative effort on the pa...

NREL Leads Effort to Get Traffic Moving in the Right Direction | News |

Science.gov Websites

fuels. This emerging approach to sustainable transportation augments ongoing work by NREL that is aimed at taking a systems approach to the broader network of travelers, services, and environments in order

Trophic Pathways of the Mid-North Atlantic

EPA Science Inventory

Because deep-sea fisheries are increasing as coastal fisheries decline, fisheries scientists need baseline data on deep-sea ecosystems prior to further development of deep-water fisheries. We present preliminary results and ongoing efforts to characterize the trophic structure a...

SnoVault and encodeD: A novel object-based storage system and applications to ENCODE metadata.

PubMed

Hitz, Benjamin C; Rowe, Laurence D; Podduturi, Nikhil R; Glick, David I; Baymuradov, Ulugbek K; Malladi, Venkat S; Chan, Esther T; Davidson, Jean M; Gabdank, Idan; Narayana, Aditi K; Onate, Kathrina C; Hilton, Jason; Ho, Marcus C; Lee, Brian T; Miyasato, Stuart R; Dreszer, Timothy R; Sloan, Cricket A; Strattan, J Seth; Tanaka, Forrest Y; Hong, Eurie L; Cherry, J Michael

2017-01-01

The Encyclopedia of DNA elements (ENCODE) project is an ongoing collaborative effort to create a comprehensive catalog of functional elements initiated shortly after the completion of the Human Genome Project. The current database exceeds 6500 experiments across more than 450 cell lines and tissues using a wide array of experimental techniques to study the chromatin structure, regulatory and transcriptional landscape of the H. sapiens and M. musculus genomes. All ENCODE experimental data, metadata, and associated computational analyses are submitted to the ENCODE Data Coordination Center (DCC) for validation, tracking, storage, unified processing, and distribution to community resources and the scientific community. As the volume of data increases, the identification and organization of experimental details becomes increasingly intricate and demands careful curation. The ENCODE DCC has created a general purpose software system, known as SnoVault, that supports metadata and file submission, a database used for metadata storage, web pages for displaying the metadata and a robust API for querying the metadata. The software is fully open-source, code and installation instructions can be found at: http://github.com/ENCODE-DCC/snovault/ (for the generic database) and http://github.com/ENCODE-DCC/encoded/ to store genomic data in the manner of ENCODE. The core database engine, SnoVault (which is completely independent of ENCODE, genomic data, or bioinformatic data) has been released as a separate Python package.

SnoVault and encodeD: A novel object-based storage system and applications to ENCODE metadata

PubMed Central

Podduturi, Nikhil R.; Glick, David I.; Baymuradov, Ulugbek K.; Malladi, Venkat S.; Chan, Esther T.; Davidson, Jean M.; Gabdank, Idan; Narayana, Aditi K.; Onate, Kathrina C.; Hilton, Jason; Ho, Marcus C.; Lee, Brian T.; Miyasato, Stuart R.; Dreszer, Timothy R.; Sloan, Cricket A.; Strattan, J. Seth; Tanaka, Forrest Y.; Hong, Eurie L.; Cherry, J. Michael

2017-01-01

The Encyclopedia of DNA elements (ENCODE) project is an ongoing collaborative effort to create a comprehensive catalog of functional elements initiated shortly after the completion of the Human Genome Project. The current database exceeds 6500 experiments across more than 450 cell lines and tissues using a wide array of experimental techniques to study the chromatin structure, regulatory and transcriptional landscape of the H. sapiens and M. musculus genomes. All ENCODE experimental data, metadata, and associated computational analyses are submitted to the ENCODE Data Coordination Center (DCC) for validation, tracking, storage, unified processing, and distribution to community resources and the scientific community. As the volume of data increases, the identification and organization of experimental details becomes increasingly intricate and demands careful curation. The ENCODE DCC has created a general purpose software system, known as SnoVault, that supports metadata and file submission, a database used for metadata storage, web pages for displaying the metadata and a robust API for querying the metadata. The software is fully open-source, code and installation instructions can be found at: http://github.com/ENCODE-DCC/snovault/ (for the generic database) and http://github.com/ENCODE-DCC/encoded/ to store genomic data in the manner of ENCODE. The core database engine, SnoVault (which is completely independent of ENCODE, genomic data, or bioinformatic data) has been released as a separate Python package. PMID:28403240

Mainstreaming Climate Change: Recent and Ongoing Efforts to Understand, Improve, and Expand Consideration of Climate Change in Federal Water Resources Planning

NASA Astrophysics Data System (ADS)

Ferguson, I. M.; McGuire, M.; Broman, D.; Gangopadhyay, S.

2017-12-01

The Bureau of Reclamation is a Federal agency tasked with developing and managing water supply and hydropower projects in the Western U.S. Climate and hydrologic variability and change significantly impact management actions and outcomes across Reclamation's programs and initiatives, including water resource planning and operations, infrastructure design and maintenance, hydropower generation, and ecosystem restoration, among others. Planning, design, and implementation of these programs therefore requires consideration of future climate and hydrologic conditions will impact program objectives. Over the past decade, Reclamation and other Federal agencies have adopted new guidelines, directives, and mandates that require consideration of climate change in water resources planning and decision making. Meanwhile, the scientific community has developed a large number of climate projections, along with an array of models, methods, and tools to facilitate consideration of climate projections in planning and decision making. However, water resources engineers, planners, and decision makers continue to face challenges regarding how best to use the available data and tools to support major decisions, including decisions regarding infrastructure investments and long-term operating criteria. This presentation will discuss recent and ongoing research towards understanding, improving, and expanding consideration of climate projections and related uncertainties in Federal water resources planning and decision making. These research efforts address a variety of challenges, including: How to choose between available climate projection datasets and related methods, models, and tools—many of which are considered experimental or research tools? How to select an appropriate decision framework when design or operating alternatives may differ between climate scenarios? How to effectively communicate results of a climate impacts analysis to decision makers? And, how to improve robustness and resilience of water resources systems in the face of significant uncertainty? Discussion will focus on the intersection between technical challenges and decision making paradigms and the need for improved scientist-decision maker engagement through the lens of this Federal water management agency.

Overview of the OGAP Formative Assessment Project and CPRE's Large-Scale Experimental Study of Implementation and Impacts

ERIC Educational Resources Information Center

Supovitz, Jonathan

2016-01-01

In this presentation discussed in this brief abstracted report, the author presents about an ongoing partnership with the Philadelphia School District (PSD) to implement and research the Ongoing Assessment Project (OGAP). OGAP is a systematic, intentional and iterative formative assessment system grounded in the research on how students learn…

Aftershocks of Chile's Earthquake for an Ongoing, Large-Scale Experimental Evaluation

ERIC Educational Resources Information Center

Moreno, Lorenzo; Trevino, Ernesto; Yoshikawa, Hirokazu; Mendive, Susana; Reyes, Joaquin; Godoy, Felipe; Del Rio, Francisca; Snow, Catherine; Leyva, Diana; Barata, Clara; Arbour, MaryCatherine; Rolla, Andrea

2011-01-01

Evaluation designs for social programs are developed assuming minimal or no disruption from external shocks, such as natural disasters. This is because extremely rare shocks may not make it worthwhile to account for them in the design. Among extreme shocks is the 2010 Chile earthquake. Un Buen Comienzo (UBC), an ongoing early childhood program in…

Harnessing case isolation and ring vaccination to control Ebola.

PubMed

Wells, Chad; Yamin, Dan; Ndeffo-Mbah, Martial L; Wenzel, Natasha; Gaffney, Stephen G; Townsend, Jeffrey P; Meyers, Lauren Ancel; Fallah, Mosoka; Nyenswah, Tolbert G; Altice, Frederick L; Atkins, Katherine E; Galvani, Alison P

2015-05-01

As a devastating Ebola outbreak in West Africa continues, non-pharmaceutical control measures including contact tracing, quarantine, and case isolation are being implemented. In addition, public health agencies are scaling up efforts to test and deploy candidate vaccines. Given the experimental nature and limited initial supplies of vaccines, a mass vaccination campaign might not be feasible. However, ring vaccination of likely case contacts could provide an effective alternative in distributing the vaccine. To evaluate ring vaccination as a strategy for eliminating Ebola, we developed a pair approximation model of Ebola transmission, parameterized by confirmed incidence data from June 2014 to January 2015 in Liberia and Sierra Leone. Our results suggest that if a combined intervention of case isolation and ring vaccination had been initiated in the early fall of 2014, up to an additional 126 cases in Liberia and 560 cases in Sierra Leone could have been averted beyond case isolation alone. The marginal benefit of ring vaccination is predicted to be greatest in settings where there are more contacts per individual, greater clustering among individuals, when contact tracing has low efficacy or vaccination confers post-exposure protection. In such settings, ring vaccination can avert up to an additional 8% of Ebola cases. Accordingly, ring vaccination is predicted to offer a moderately beneficial supplement to ongoing non-pharmaceutical Ebola control efforts.

Plasma Potential and Langmuir Probe Measurements in the Near-field Plume of the NASA 300M Hall Thruster

NASA Technical Reports Server (NTRS)

Herman, Daniel A; Shastry, Rohit; Huang, Wensheng; Soulas, George C.; KamHawi, Hani

2012-01-01

In order to aid in the design of high-power Hall thrusters and provide experimental validation for existing modeling efforts, plasma potential and Langmuir probe measurements were performed in the near-field plume of the NASA 300M Hall thruster. A probe array consisting of a Faraday probe, Langmuir probe, and emissive probe was used to interrogate the plume from approximately 0.1 - 2.0 DT,m downstream of the thruster exit plane at four operating conditions: 300 V, 400 V, and 500 V at 20 kW as well as 300 V at 10 kW. Results show that the acceleration zone and high-temperature region were contained within 0.3 DT,m from the exit plane at all operating conditions. Isothermal lines were shown to strongly follow magnetic field lines in the nearfield, with maximum temperatures ranging from 19 - 27 eV. The electron temperature spatial distribution created large drops in measured floating potentials in front of the magnetic pole surfaces where the plasma density was small, which suggests strong sheaths at these surfaces. The data taken have provided valuable information for future design and modeling validation, and complements ongoing internal measurement efforts on the NASA 300 M.

Contra-Rotating Open Rotor Tone Noise Prediction

NASA Technical Reports Server (NTRS)

Envia, Edmane

2014-01-01

Reliable prediction of contra-rotating open rotor (CROR) noise is an essential element of any strategy for the development of low-noise open rotor propulsion systems that can meet both the community noise regulations and the cabin noise limits. Since CROR noise spectra typically exhibits a preponderance of tones, significant efforts have been directed towards predicting their tone spectra. To that end, there has been an ongoing effort at NASA to assess various in-house open rotor tone noise prediction tools using a benchmark CROR blade set for which significant aerodynamic and acoustic data had been acquired in wind tunnel tests. In the work presented here, the focus is on the near-field noise of the benchmark open rotor blade set at the cruise condition. Using an analytical CROR tone noise model with input from high-fidelity aerodynamic simulations, detailed tone noise spectral predictions have been generated and compared with the experimental data. Comparisons indicate that the theoretical predictions are in good agreement with the data, especially for the dominant CROR tones and their overall sound pressure level. The results also indicate that, whereas individual rotor tones are well predicted by the linear sources (i.e., thickness and loading), for the interaction tones it is essential that the quadrupole sources be included in the analysis.

Contra-Rotating Open Rotor Tone Noise Prediction

NASA Technical Reports Server (NTRS)

Envia, Edmane

2014-01-01

Reliable prediction of contra-rotating open rotor (CROR) noise is an essential element of any strategy for the development of low-noise open rotor propulsion systems that can meet both the community noise regulations and cabin noise limits. Since CROR noise spectra exhibit a preponderance of tones, significant efforts have been directed towards predicting their tone content. To that end, there has been an ongoing effort at NASA to assess various in-house open rotor tone noise prediction tools using a benchmark CROR blade set for which significant aerodynamic and acoustic data have been acquired in wind tunnel tests. In the work presented here, the focus is on the nearfield noise of the benchmark open rotor blade set at the cruise condition. Using an analytical CROR tone noise model with input from high-fidelity aerodynamic simulations, tone noise spectra have been predicted and compared with the experimental data. Comparisons indicate that the theoretical predictions are in good agreement with the data, especially for the dominant tones and for the overall sound pressure level of tones. The results also indicate that, whereas the individual rotor tones are well predicted by the combination of the thickness and loading sources, for the interaction tones it is essential that the quadrupole source is also included in the analysis.

Isolation and characterization of an H9N2 influenza virus isolated in Argentina

PubMed Central

Xu, Kemin; Ferreri, Lucas; Rimondi, Agustina; Olivera, Valeria; Romano, Marcelo; Ferreyra, Hebe; Rago, Virgina; Uhart, Marcela; Chen, Hongjun; Sutton, Troy; Pereda, Ariel; Perez, Daniel R.

2016-01-01

As part of our ongoing efforts on animal influenza surveillance in Argentina, an H9N2 virus was isolated from a wild aquatic bird (Netta peposaca), A/rosy-billed pochard/Argentina/CIP051-559/2007 (H9N2) – herein referred to as 559/H9N2. Due to the important role that H9N2 viruses play in the ecology of influenza in nature, the 559/H9N2 isolate was characterized molecularly and biologically. Phylogenetic analysis of the HA gene revealed that the 559/H9N2 virus maintained an independent evolutionary pathway and shared a sister-group relationship with North American viruses, suggesting a common ancestor. The rest of the genome segments clustered with viruses from South America. Experimental inoculation of the 559/H9N2 in chickens and quail revealed efficient replication and transmission only in quail. Our results add to the notion of the unique evolutionary trend of avian influenza viruses in South America. Our study increases our understanding of H9N2 viruses in nature and emphasizes the importance of expanding animal influenza surveillance efforts to better define the ecology of influenza viruses at a global scale. PMID:22709552

A neuroscience perspective on sexual risk behavior in adolescence and emerging adulthood

PubMed Central

VICTOR, ELIZABETH C.; HARIRI, AHMAD R.

2016-01-01

Late adolescence and emerging adulthood (specifically ages 15–24) represent a period of heightened sexual risk taking resulting in the greatest annual rates of sexually transmitted infections and unplanned pregnancies in the US population. Ongoing efforts to prevent such negative consequences are likely to benefit from a deepening of our understanding of biological mechanisms through which sexual risk taking emerges and biases decision making during this critical window. Here we present a neuroscience framework from which a mechanistic examination of sexual risk taking can be advanced. Specifically, we adapt the neurodevelopmental triadic model, which outlines how motivated behavior is governed by three systems: approach, avoidance, and regulation, to sexual decision making and subsequent risk behavior. We further propose a testable hypothesis of the triadic model, wherein relatively decreased threat-related amygdala reactivity and increased reward-related ventral striatum reactivity leads to sexual risk taking, which is particularly exaggerated during adolescence and young adulthood when there is an overexpression of dopaminergic neurons coupled with immature top-down prefrontal cortex regulation. We conclude by discussing how future research based on our adapted triadic model can inform ongoing efforts to improve intervention and prevention efforts. PMID:26611719

A review of HIV/AIDS system-level interventions

PubMed Central

Bauermeister, José A.; Tross, Susan; Ehrhardt, Anke A.

2010-01-01

The escalating HIV/AIDS epidemic worldwide demands that on-going prevention efforts be strengthened, disseminated, and scaled-up. System-level interventions refer to programs aiming to improve the functioning of an agency as well as the delivery of its services to the community. System-level interventions are a promising approach to HIV/AIDS prevention because they focus on (a) improving the agency’s ability to adopt evidence-based HIV prevention and care programs; (b) develop and establish policies and procedures that maximize the sustainability of on-going prevention and care efforts; and (c) improve decision-making processes such as incorporating the needs of communities into their tailored services. We reviewed studies focusing on system-level interventions by searching multiple electronic abstracting indices, including PsycInfo, PubMed, and ProQuest. Twenty-three studies out of 624 peer-reviewed studies (published from January 1985 to February 2007) met study criteria. Most of the studies focused on strengthening agency infrastructure, while other studies included collaborative partnerships and technical assistance programs. Our findings suggest that system-level interventions are promising in strengthening HIV/AIDS prevention and treatment efforts. Based on our findings, we propose recommendations for future work in developing and evaluating system-level interventions. PMID:18369722

Simulation and Optimization of Vacuum Swing Adsorption Units for Spacesuit Carbon Dioxide and Humidity Control

NASA Technical Reports Server (NTRS)

Swickrath, Michael J.; Anderson, Molly; McMillin, Summer; Broerman, Craig

2011-01-01

Controlling carbon dioxide (CO2) and humidity levels in a spacesuit is critical to ensuring both the safety and comfort of an astronaut during extra-vehicular activity (EVA). Traditionally, this has been accomplished utilizing either non-regenerative lithium hydroxide (LiOH) or regenerative but heavy metal oxide (MetOx) canisters which pose a significant weight burden. Although such technology enables air revitalization, the volume requirements to store the waste canisters as well as the mass to transport multiple units become prohibitive as mission durations increase. Consequently, motivation exists toward developing a fully regenerative technology for spacesuit environmental control. The application of solid amine materials with vacuum swing adsorption technology has shown the capacity to control CO2 while concomitantly managing humidity levels through a fully regenerative cycle eliminating constraints imposed with the traditional technologies. Prototype air revitalization units employing this technology have been fabricated in both a rectangular and cylindrical geometry. Experimental results for these test articles have been collected and are described herein. In order to accelerate the developmental efforts, an axially-dispersed plug flow model with an accompanying energy balance has been established and correlated with the experimental data. The experimental and simulation results display good agreement for a variety of flow rates (110-170 ALM), replicated metabolic challenges (100-590 Watts), and atmosphere pressures under consideration for the spacesuit (248 and 760 mm Hg). The testing and model results lend insight into the operational capabilities of these devices as well as the influence the geometry of the device has on performance. In addition, variable metabolic profiles were imposed on the test articles in order to assess the ability of the technology to transition to new metabolic conditions. The advent of the model provides the capacity to apply computer-aided engineering practices to support the ongoing efforts to optimize and mature this technology for future application to space exploration.

77 FR 66609 - Notice of FERC Staff Attendance; PacifiCorp, et al.

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-06

...-82-000 El Paso Electric Company ER13-91-000 Black Hills Power, Inc., et al......... ER13-96-000 Black... Commission's ongoing outreach efforts. The meeting may discuss matters at issue in the above captioned...

Guidelines for development of the Iowa statewide transportation improvement program (STIP). Revised.

DOT National Transportation Integrated Search

2004-01-01

The Transportation Equity Act for the 21st Century (TEA-21) continues the Intermodal Surface Transportation Efficiency Act of 1991's requirement for an extensive, ongoing cooperative planning effort for programming federal funding. Iowa's STIP is dev...

Clean Water State Revolving Fund (CWSRF) Environmental Benefits Report

EPA Pesticide Factsheets

This report is a snapshot of the CWSRF’s positive role in improving our nation’s waters to support the goals of the CWA. The report also highlights ongoing CWSRF efforts to improve infrastructure resiliency against extreme weather events.

Analysis and recommendation of separation requirements for rotorcraft operation at airports and heliports

DOT National Transportation Integrated Search

1986-09-01

The analysis work presented in this report is part of an ongoing effort by the Federal Aviation Administration (FAA) to develop improved rotorcraft separation standards. The subject of this report, Analysis and Recommendation of Separation Requiremen...

77 FR 1060 - Proposed Information Collection; Comment Request; Survey of the Need for the Improvement of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-09

... ). SUPPLEMENTARY INFORMATION: I. Abstract This is a request for a new information collection. The Sensor Science... ongoing effort, and in response to many inquiries and requests in recent years, NIST plans to survey...

Data: The Common Thread & Tie That Binds Exposure Science

EPA Science Inventory

While a number of ongoing efforts exist aimed at empirically measuring or modeling exposure data, problems persist regarding availability and access to this data. Innovations in managing proprietary data, establishing data quality, standardization of data sets, and sharing of exi...

MODEL HARMONIZATION POTENTIAL AND BENEFITS

EPA Science Inventory

The IPCS Harmonization Project, which is currently ongoing under the auspices of the WHO, in the context of chemical risk assessment or exposure modeling, does not imply global standardization. Instead, harmonization is thought of as an effort to strive for consistency among appr...

Compendium of GAO’s Views on the Cost Saving Proposals of the Grace Commission. Volume 1. Summary of Findings.

DTIC Science & Technology

1985-02-19

effort to develop a govern- ment-wide integrated financial management structure. Such an effort must have a solid base of fundamental concepts to guide ...initiatives address many PPSSCC debt collection concerns The PPSSCC recommendations basically parallel our prior *- recommendations and ongoing OMB...PPSSCC recommended either selling the PMAs’ facilities or adjusting the PMAs’ user fees, ratemaking process, and pricina structure. In total, the PPSSCC

A Critical Examination of the DOD’s Business Management Modernization Program

DTIC Science & Technology

2005-05-01

Program (BMMP) is a key element of the DoD’s ongoing efforts to transform itself. This paper argues that the BMMP needs to be fundamentally reoriented...communication role it plays in the defense- transformation effort. Introduction The core assumption underlying the DoD’s Business Management... government activities. That this is a core assumption for the BMMP is borne out by the fact that the program’s primary objective is to produce

Infusing Software Engineering Technology into Practice at NASA

NASA Technical Reports Server (NTRS)

Pressburger, Thomas; Feather, Martin S.; Hinchey, Michael; Markosia, Lawrence

2006-01-01

We present an ongoing effort of the NASA Software Engineering Initiative to encourage the use of advanced software engineering technology on NASA projects. Technology infusion is in general a difficult process yet this effort seems to have found a modest approach that is successful for some types of technologies. We outline the process and describe the experience of the technology infusions that occurred over a two year period. We also present some lessons from the experiences.

Overview of NASA tire experimental programs

NASA Technical Reports Server (NTRS)

Tanner, J. A.

1983-01-01

Ongoing aircraft tire experimental programs are reported. These programs are designed to measure profile growth due to inflation pressure and vertical loading, contact pressures in the tire footprint, and a number of tire mechanical properties including spring, damping, and relaxation characteristics.

Laboratory Evaluation of Concrete Ties and Fastenings for Transit Use

DOT National Transportation Integrated Search

1979-03-01

This report was prepared as part of an ongoing research effort by the Urban Mass Transportation Administration (UMTA) to develop standard concrete ties for rapid transit use. The overall objective of this contract was to fabricate and evaluate, by la...

Trials advance low-salinity culture of Cobia, Pompano, and other species

USDA-ARS?s Scientific Manuscript database

An ongoing collaborative research effort between scientists of the USDA Agricultural Research Service and aquaculture researchers of the Harbor Branch Oceanographic Institute at Florida Atlantic University to develop technologies for rearing fish in low salinity recirculating aquaculture systems is ...

The silent customers: measuring customer satisfaction in nursing homes.

PubMed

Kleinsorge, I K; Koenig, H F

1991-12-01

Nursing home administrators concerned with customer satisfaction and quality of care need a tool to assess and monitor ongoing satisfaction of nursing home residents and family members. The authors report a preliminary effort to develop such a survey using focus groups.

THE OPEN SOURCING OF EPANET

EPA Science Inventory

A proposal was made at the 2009 EWRI Congress in Kansas City, MO to establish an Open Source Project (OSP) for the widely used EPANET pipe network analysis program. This would be an ongoing collaborative effort among a group of geographically dispersed advisors and developers, wo...

Midwest regional rail system : a transportation network for the 21 century : executive report

DOT National Transportation Integrated Search

2000-02-01

The Midwest Regional Rail Initiative is an ongoing effort to develop an improved and expanded passenger rail system in the Midwest. Since 1996, the Midwest Regional Rail Initiative (MWRRI) advanced from a series of service concepts, including increas...

Workshops and Training | Eliminating Sanitary Sewer ...

EPA Pesticide Factsheets

2017-04-10

EPA New England is working with partners to develop outreach, workshops and tools to assist those working to prevent sewage overflows and improve the management of water/wastewater systems. We have ongoing efforts on CMOM (Capacity, Management, Operation and Maintenance), Asset Management and energy management.

Computer Augmented Video Education.

ERIC Educational Resources Information Center

Sousa, M. B.

1979-01-01

Describes project CAVE (Computer Augmented Video Education), an ongoing effort at the U.S. Naval Academy to present lecture material on videocassette tape, reinforced by drill and practice through an interactive computer system supported by a 12 channel closed circuit television distribution and production facility. (RAO)

Holes: a novel method for promoting vegetation restoration (Macao)

Treesearch

Shao-Lin Peng; Yi-Na Yu; Yu-Ping Hou; Long-Sheng Yu; Bao-Ming Chen

2009-01-01

Restoration Notes have been a distinguishing feature of Ecological Restoration for more than 25 years. This section is geared toward introducing innovative research, tools, technologies, programs, and ideas, as well as providing short-term research results and updates on ongoing efforts.

Reducing the Risk of Tick-Borne Diseases through Smart, Safe and Sustainable Pest Control

EPA Pesticide Factsheets

Each year PestWise programs form new partnerships to address ongoing and emerging issues. Reducing the risk from ticks and tick-borne disease is an issue of importance and EPA is contributing to a larger federal effort.

Oyster School Stands the Test of Time.

ERIC Educational Resources Information Center

Fern, Veronica

1995-01-01

Describes Oyster Elementary School's award-winning two-way bilingual (Spanish-English) program. The school's success has been maintained by strong parent and community support, high academic standards, and ongoing professional development efforts. However, cultural, generational, and socioeconomic differences among staff, students, and parents…

Braille Goes to High School.

ERIC Educational Resources Information Center

Amato, Sheila

2003-01-01

This brief report describes the development and implementation of a unique, full-year, credit-bearing, technology course in literary Braille transcription offered at a Long Island (New York) high school. It describes the program's goals, development, implementation, students, ongoing activities, outreach efforts, and student attitudes. Suggestions…

Data Validation and Sharing in a Large Research Program

EPA Science Inventory

Appropriate data handling practices are important in the support of large research teams with shifting and competing priorities. Determining those best practices is an ongoing effort for the US EPA’s National Aquatic Resource Surveys. We focus on the well understood data ...

Quantifying uncertainty in read-across assessment – an algorithmic approach - (SOT)

EPA Science Inventory

Read-across is a popular data gap filling technique within category and analogue approaches for regulatory purposes. Acceptance of read-across remains an ongoing challenge with several efforts underway for identifying and addressing uncertainties. Here we demonstrate an algorithm...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This program summary describes each of the DOE's Biomass Energy System's projects funded or in existence during fiscal year 1979 and reflects their status as of September 30, 1979. The summary provides an overview of the ongoing research, development, and demonstration efforts of the preceding fiscal year as well. (DMC)

Safety | Argonne National Laboratory

Science.gov Websites

laboratory's ongoing effort to provide a safe and productive environment for employees, users, other site Skip to main content Argonne National Laboratory Toggle Navigation Toggle Search Energy Environment Careers Education Community Diversity Directory Energy Environment National Security User Facilities

HYDRODYNAMIC AND TRANSPORT MODELING STUDY IN A HIGHLY STRATIFIED ESTUARY

EPA Science Inventory

This paper presents the preliminary results of hydrodynamic and salinity predictions and the implications to an ongoing contaminated sediment transport and fate modeling effort in the Lower Duwamish Waterway (LDW), Seattle, Washington. The LDW is highly strati-fied when freshwate...

Validation and application of highway safety manual (part D) in Florida : [summary].

DOT National Transportation Integrated Search

2014-02-01

Ongoing surveillance programs on roads and : highways in the U.S. have produced large amounts : of data on many aspects of transportation. : Crash statistics are among the most important : products of these efforts as they help engineers : pinpoint c...

Reggio Social Capital

ERIC Educational Resources Information Center

Stejzygier, Aneta

2009-01-01

The paper presents the social capital as the essential element of success of the Reggio Emilia preschools known for their unique approach to the early childhood education. The collaborative effort is introduced through examples of the currently ongoing "Reggio Narrates" project of Reggio preschools, the "Dialogue with the…

Engine rotor health monitoring: an experimental approach to fault detection and durability assessment

NASA Astrophysics Data System (ADS)

Abdul-Aziz, Ali; Woike, Mark R.; Clem, Michelle; Baaklini, George

2015-03-01

Efforts to update and improve turbine engine components in meeting flights safety and durability requirements are commitments that engine manufacturers try to continuously fulfill. Most of their concerns and developments energies focus on the rotating components as rotor disks. These components typically undergo rigorous operating conditions and are subject to high centrifugal loadings which subject them to various failure mechanisms. Thus, developing highly advanced health monitoring technology to screen their efficacy and performance is very essential to their prolonged service life and operational success. Nondestructive evaluation techniques are among the many screening methods that presently are being used to pre-detect hidden flaws and mini cracks prior to any appalling events occurrence. Most of these methods or procedures are confined to evaluating material's discontinuities and other defects that have mature to a point where failure is eminent. Hence, development of more robust techniques to pre-predict faults prior to any catastrophic events in these components is highly vital. This paper is focused on presenting research activities covering the ongoing research efforts at NASA Glenn Research Center (GRC) rotor dynamics laboratory in support of developing a fault detection system for key critical turbine engine components. Data obtained from spin test experiments of a rotor disk that relates to investigating behavior of blade tip clearance, tip timing and shaft displacement based on measured data acquired from sensor devices such as eddy current, capacitive and microwave are presented. Additional results linking test data with finite element modeling to characterize the structural durability of a cracked rotor as it relays to the experimental tests and findings is also presented. An obvious difference in the vibration response is shown between the notched and the baseline no notch rotor disk indicating the presence of some type of irregularity.

Systems approach to monitoring and evaluation guides scale up of the Standard Days Method of family planning in Rwanda.

PubMed

Igras, Susan; Sinai, Irit; Mukabatsinda, Marie; Ngabo, Fidele; Jennings, Victoria; Lundgren, Rebecka

2014-05-01

There is no guarantee that a successful pilot program introducing a reproductive health innovation can also be expanded successfully to the national or regional level, because the scaling-up process is complex and multilayered. This article describes how a successful pilot program to integrate the Standard Days Method (SDM) of family planning into existing Ministry of Health services was scaled up nationally in Rwanda. Much of the success of the scale-up effort was due to systematic use of monitoring and evaluation (M&E) data from several sources to make midcourse corrections. Four lessons learned illustrate this crucially important approach. First, ongoing M&E data showed that provider training protocols and client materials that worked in the pilot phase did not work at scale; therefore, we simplified these materials to support integration into the national program. Second, triangulation of ongoing monitoring data with national health facility and population-based surveys revealed serious problems in supply chain mechanisms that affected SDM (and the accompanying CycleBeads client tool) availability and use; new procedures for ordering supplies and monitoring stockouts were instituted at the facility level. Third, supervision reports and special studies revealed that providers were imposing unnecessary medical barriers to SDM use; refresher training and revised supervision protocols improved provider practices. Finally, informal environmental scans, stakeholder interviews, and key events timelines identified shifting political and health policy environments that influenced scale-up outcomes; ongoing advocacy efforts are addressing these issues. The SDM scale-up experience in Rwanda confirms the importance of monitoring and evaluating programmatic efforts continuously, using a variety of data sources, to improve program outcomes.

Systems approach to monitoring and evaluation guides scale up of the Standard Days Method of family planning in Rwanda

PubMed Central

Igras, Susan; Sinai, Irit; Mukabatsinda, Marie; Ngabo, Fidele; Jennings, Victoria; Lundgren, Rebecka

2014-01-01

There is no guarantee that a successful pilot program introducing a reproductive health innovation can also be expanded successfully to the national or regional level, because the scaling-up process is complex and multilayered. This article describes how a successful pilot program to integrate the Standard Days Method (SDM) of family planning into existing Ministry of Health services was scaled up nationally in Rwanda. Much of the success of the scale-up effort was due to systematic use of monitoring and evaluation (M&E) data from several sources to make midcourse corrections. Four lessons learned illustrate this crucially important approach. First, ongoing M&E data showed that provider training protocols and client materials that worked in the pilot phase did not work at scale; therefore, we simplified these materials to support integration into the national program. Second, triangulation of ongoing monitoring data with national health facility and population-based surveys revealed serious problems in supply chain mechanisms that affected SDM (and the accompanying CycleBeads client tool) availability and use; new procedures for ordering supplies and monitoring stockouts were instituted at the facility level. Third, supervision reports and special studies revealed that providers were imposing unnecessary medical barriers to SDM use; refresher training and revised supervision protocols improved provider practices. Finally, informal environmental scans, stakeholder interviews, and key events timelines identified shifting political and health policy environments that influenced scale-up outcomes; ongoing advocacy efforts are addressing these issues. The SDM scale-up experience in Rwanda confirms the importance of monitoring and evaluating programmatic efforts continuously, using a variety of data sources, to improve program outcomes. PMID:25276581

Hydrothermal monitoring in a quiescent volcanic arc: Cascade Range, northwestern United States

USGS Publications Warehouse

Ingebritsen, S.E.; Randolph-Flagg, N. G.; Gelwick, K.D.; Lundstrom, E.A.; Crankshaw, I.M.; Murveit, A.M.; Schmidt, M.E.; Bergfeld, D.; Spicer, K.R.; Tucker, D.S.; Mariner, R.H.; Evans, William C.

2014-01-01

Ongoing (1996–present) volcanic unrest near South Sister, Oregon, is accompanied by a striking set of hydrothermal anomalies, including elevated temperatures, elevated major ion concentrations, and 3He/4He ratios as large as 8.6 RA in slightly thermal springs. These observations prompted the US Geological Survey to begin a systematic hydrothermal-monitoring effort encompassing 25 sites and 10 of the highest-risk volcanoes in the Cascade volcanic arc, from Mount Baker near the Canadian border to Lassen Peak in northern California. A concerted effort was made to develop hourly, multiyear records of temperature and/or hydrothermal solute flux, suitable for retrospective comparison with other continuous geophysical monitoring data. Targets included summit fumarole groups and springs/streams that show clear evidence of magmatic influence in the form of high 3He/4He ratios and/or anomalous fluxes of magmatic CO2 or heat. As of 2009–2012, summit fumarole temperatures in the Cascade Range were generally near or below the local pure water boiling point; the maximum observed superheat was 3 during periods of hourly record. Hydrothermal responses to these small seismic stimuli were generally undetectable or ambiguous. Evaluation of multiyear to multidecadal trends indicates that whereas the hydrothermal system at Mount St. Helens is still fast-evolving in response to the 1980–present eruptive cycle, there is no clear evidence of ongoing long-term trends in hydrothermal activity at other Cascade Range volcanoes that have been active or restless during the past century (Baker, South Sister, and Lassen). Experience gained during the Cascade Range hydrothermal-monitoring experiment informs ongoing efforts to capture entire unrest cycles at more active but generally less accessible volcanoes such as those in the Aleutian arc.

The role of CT in professionalism: accreditation, certification and the welfare of our children.

PubMed

Frush, Donald P

2011-09-01

Defining, measuring and promoting professionalism in medicine, including radiology, has been increasingly emphasized by organizations such as ACGME, the ACR and ABR. It is clear that we as imaging experts have as an ultimate responsibility the welfare of our patients. This is the essence of professionalism, and major societies such as the ACR, ABR and RSNA are embracing professionalism through ongoing safety and training efforts. Some of those efforts in accreditation of equipment and certification of medical professionals will be discussed.

Progress Toward HIV Eradication: Case Reports, Current Efforts, and the Challenges Associated with Cure.

PubMed

Martin, Alyssa R; Siliciano, Robert F

2016-01-01

An estimated 35 million people worldwide are infected with HIV, yet a widely applicable cure strategy remains elusive. Recent case reports have suggested that curing HIV infection is possible, renewing excitement about research efforts. We describe those cases and discuss their relevance to the global HIV epidemic. We also review ongoing cure strategies that are transitioning from the lab to the clinic, and the assays and clinical assessments that can be used to evaluate cure interventions.

Student laboratory reports: an approach to improving feedback and quality

NASA Astrophysics Data System (ADS)

Ellingsen, Pål Gunnar; Støvneng, Jon Andreas

2018-05-01

We present an ongoing effort in improving the quality of laboratory reports written by first and second year physics students. The effort involves a new approach where students are given the opportunity to submit reports at intermediate deadlines, receive feedback, and then resubmit for the final deadline. In combination with a differential grading system, instead of pass/fail, the improved feedback results in higher quality reports. Improvement in the quality of the reports is visible through the grade statistics.

Avionics Architectures for Exploration: Wireless Technologies and Human Spaceflight

NASA Technical Reports Server (NTRS)

Goforth, Montgomery B.; Ratliff, James E.; Barton, Richard J.; Wagner, Raymond S.; Lansdowne, Chatwin

2014-01-01

The authors describe ongoing efforts by the Avionics Architectures for Exploration (AAE) project chartered by NASA's Advanced Exploration Systems (AES) Program to evaluate new avionics architectures and technologies, provide objective comparisons of them, and mature selected technologies for flight and for use by other AES projects. The AAE project team includes members from most NASA centers and from industry. This paper provides an overview of recent AAE efforts, with particular emphasis on the wireless technologies being evaluated under AES to support human spaceflight.

Review and Synopsis of Natural and Human Controls on Fluvial Channel Processes in the Arid West

DTIC Science & Technology

2007-09-01

Parallel to ongoing efforts to revise the U.S. Army Corps of Engineers wetland delineation manual for support of Section 404 under the Clean Water ...Act, the Corps has initiated an effort to develop an Ordinary High Water (OHW) delineation manual. The Arid West region is dominated by watersheds with...features. With a better understanding of the stream dynamics associated with regulated ordinary events, the Corps is now developing OHW functional models

The early Earth Observing System reference handbook: Earth Science and Applications Division missions, 1990-1997

NASA Technical Reports Server (NTRS)

1990-01-01

Prior to the launch of the Earth Observing System (EOS) series, NASA will launch and operate a wide variety of new earth science satellites and instruments, as well as undertake several efforts collecting and using the data from existing and planned satellites from other agencies and nations. These initiatives will augment the knowledge base gained from ongoing Earth Science and Applications Division (ESAD) programs. This volume describes three sets of ESAD activities -- ongoing exploitation of operational satellite data, research missions with upcoming launches between now and the first launch of EOS, and candidate earth probes.

Development of Gene Therapy for Thalassemia

PubMed Central

Nienhuis, Arthur W.; Persons, Derek A.

2012-01-01

Retroviral vector–mediated gene transfer into hematopoietic stem cells provides a potentially curative therapy for severe β-thalassemia. Lentiviral vectors based on human immunodeficiency virus have been developed for this purpose and have been shown to be effective in curing thalassemia in mouse models. One participant in an ongoing clinical trial has achieved transfusion independence after gene transfer into bone marrow stem cells owing, in part, to a genetically modified, dominant clone. Ongoing efforts are focused on improving the efficiency of lentiviral vector–mediated gene transfer into stem cells so that the curative potential of gene transfer can be consistently achieved. PMID:23125203

Vehicle postmortem and data analysis of a passenger rail car collision test

DOT National Transportation Integrated Search

2002-04-23

There is an ongoing research program in the United States to investigate and improve rail equipment crashworthiness. As part of this effort, a series of full-scale rail vehicle crash tests are being performed to investigate the crash response of exis...

Plant distributions along salinity and tidal gradients in Oregon tidal marshes

EPA Science Inventory

Accurately modeling climate change effects on tidal marshes in the Pacific Northwest requires understanding how plant assemblages and species are presently distributed along gradients of salinity and tidal inundation. We outline on-going field efforts by the EPA and USGS to dete...

Leaders in School Social Work: Lela B. Costin.

ERIC Educational Resources Information Center

Anderson, Richard J.

1996-01-01

Profiles the accomplishments of a pioneer in school social work research and education. Tells how she balanced home life with professional life. Highlights her ongoing efforts to subsume school social work as a part of child welfare and the mental health of children. (RJM)

DESIGNING MONITORING AND ASSESSMENT STRATEGIES TO INCLUDE NEARSHORE ECOSYSTEMS OF THE GREAT LAKES

EPA Science Inventory

An expectation for monitoring and assessment of very large aquatic systems is that we can develop a strategy that recognizes and reports on ecologically-important subareas using spatially-stratified, probabilistic sampling designs. Ongoing efforts monitor the main-body, offshore ...

Who asks questions at astronomy meetings?

NASA Astrophysics Data System (ADS)

Schmidt, Sarah J.; Davenport, James R. A.

2017-06-01

Over the last decade, significant attention has been drawn to the gender ratio of speakers at conferences, with ongoing efforts for meetings to better reflect the gender representation in the field. We find that women are significantly under-represented, however, among the astronomers asking questions after talks.

ESP IMPROVEMENTS AT POWER PLANTS

EPA Science Inventory

An on-going ORD and OIA collaborative project in the Newly Independent States (NIS) is designed to upgrade ESPs used in NIS power plants and has laid the foundation for implementing cost-effective ESP modernization efforts at power plants. Thus far, state-of-the-art ESP performan...

Application of ISO 9000 Standards to Education and Training.

ERIC Educational Resources Information Center

Van den Berghe, Wouter

1998-01-01

ISO 9000 certification has the advantages of a measurable framework for quality efforts, continuous improvement, and better customer service. Drawbacks for education and training providers include volume of paperwork, ongoing cost, risk of a growing bureaucracy, and the difficulty of making changes quickly. (SK)

Meta-Evaluation

ERIC Educational Resources Information Center

Stufflebeam, Daniel L.

2011-01-01

Good evaluation requires that evaluation efforts themselves be evaluated. Many things can and often do go wrong in evaluation work. Accordingly, it is necessary to check evaluations for problems such as bias, technical error, administrative difficulties, and misuse. Such checks are needed both to improve ongoing evaluation activities and to assess…

HiRISE Characterization of Thermophysical Units at Acidalia Planitia, Mars

NASA Astrophysics Data System (ADS)

Martinez-Alonso, S.; Mellon, M. T.; Rafkin, S. C. R.; Zurek, R. W.; McEwen, A. S.; Putzig, N. E.; Searls, M. L.; HiRISE Team

2008-03-01

As part of an ongoing effort to characterize with HiRISE data the global thermophysical units in Mars, we report results regarding a region of Acidalia Planitia, which includes the largest outcrop of thermophysical unit F (rocks, bedrock, duricrust) on the planet.

XENOBIOTIC INDUCED ORGAN-SPECIFIC GENE EXPRESSION AND MACRO/MICROARRAY DEVELOPMENT IN MEDAKA (ORYZIAS LATIPES)

EPA Science Inventory

As part of an ongoing effort to understand and address the short and long-term consequences of increasing levels of environmental contaminants, we used suppressive subtractive hydridization (SSH) to develop gene expression profiles from Japanese medaka (Oryzias latipes) exposed ...

76 FR 56128 - Retrospective Review of Existing Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-12

..., welfare, safety, and our environment while promoting economic growth, innovation, competitiveness, and job creation.'' In furtherance of its ongoing efforts to update regulations to reflect market developments and... Commission in considering the development of a plan for the retrospective review of its regulations. DATES...

76 FR 33065 - Adaptation of Regulations to Incorporate Swaps

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-07

... retention period for any communication medium (e.g., oral communications) should be shorter than the... Commission's] ongoing efforts to facilitate the use of electronic technology and media'') \\45\\ applies... on electronic storage media, provided, however, that for electronic records, the storage media must...

Syria: health in a country undergoing tragic transition.

PubMed

Ben Taleb, Ziyad; Bahelah, Raed; Fouad, Fouad M; Coutts, Adam; Wilcox, Meredith; Maziak, Wasim

2015-01-01

To document the ongoing destruction as a result of the tragic events in Syria, to understand the changing health care needs and priorities of Syrians. A directed examination of the scientific literature and reports about Syria before and during the Syrian conflict, in addition to analyzing literature devoted to the relief and rebuilding efforts in crisis situations. The ongoing war has had high direct war casualty, but even higher suffering due to the destruction of health system, displacement, and the breakdown of livelihood and social fabric. Millions of Syrians either became refugees or internally displaced, and about half of the population is in urgent need for help. Access to local and international aid organizations for war-affected populations is an urgent and top priority. Syrians continue to endure one of the biggest human tragedies in modern times. The extent of the crisis has affected all aspects of Syrians' life. Understanding the multi-faceted transition of the Syrian population and how it reflects on their health profile can guide relief and rebuilding efforts' scope and priorities.

Novel Concepts for HIV Vaccine Vector Design.

PubMed

Alayo, Quazim A; Provine, Nicholas M; Penaloza-MacMaster, Pablo

2017-01-01

The unprecedented challenges of developing effective vaccines against intracellular pathogens such as HIV, malaria, and tuberculosis have resulted in more rational approaches to vaccine development. Apart from the recent advances in the design and selection of improved epitopes and adjuvants, there are also ongoing efforts to optimize delivery platforms. Viral vectors are the best-characterized delivery tools because of their intrinsic adjuvant capability, unique cellular tropism, and ability to trigger robust adaptive immune responses. However, a known limitation of viral vectors is preexisting immunity, and ongoing efforts are aimed at developing novel vector platforms with lower seroprevalence. It is also becoming increasingly clear that different vectors, even those derived from phylogenetically similar viruses, can elicit substantially distinct immune responses, in terms of quantity, quality, and location, which can ultimately affect immune protection. This review provides a summary of the status of viral vector development for HIV vaccines, with a particular focus on novel viral vectors and the types of adaptive immune responses that they induce.

MIT research in telerobotics

NASA Technical Reports Server (NTRS)

Sheridan, T. B.

1987-01-01

Ongoing MIT research in telerobotics (vehicles capable of some autonomous sensing and manipulating, having some remote supervisory control by people) and teleoperation (vehicles for sensing and manipulating which are fully controlled remotely by people) is discussed. The current efforts mix human and artificial intelligence/control. The idea of adjustable impedance at either end of pure master-slave teleoperation, and simultaneous coordinated control of teleoperator/telerobotic systems which have more than six degrees of freedom (e.g., a combined vehicle and arm, each with five or six DOF) are discussed. A new cable-controlled parallel link arm which offers many advantages over conventional arms for space is briefly described. Predictor displays to compensate for time delay in teleoperator loops, the use of state estimation to help human control decisions in space, and ongoing research in supervisory command language are covered. Finally, efforts to build a human flyable real-time dynamic computer-graphic telerobot simulator are described. These projects represent most, but not all, of the telerobotics research in our laboratory, supported by JPL, NASA Ames and NOAA.

K-Band Reflectarray Antenna Based on Ferroelectric Thin Films: What Have We Learned so Far

NASA Technical Reports Server (NTRS)

Miranda, Felix A.; Romanofsky, Robert; Mueller, Carl H.; VanKeuls, Fred

2002-01-01

The Applied RF Technology Branch of the NASA Glenn Research Center, Cleveland, Ohio, has an on-going effort in the area of thin film ferroelectric technology for microwave applications. Particular attention has been given to developing ferroelectric phase shifters for the implementation and experimental demonstration of an electronically steerable reflectarray antenna. In the process of optimizing these material to fit the implementation requirements of the aforementioned antenna, we have accumulated a great deal of information and knowledge in areas such as the effect of the composition of the ferroelectric thin films on phase shifter performance, self assembled monolayers (SAMs) in the metallic/ferroelectric interface and their impact on phase shifter performance, correlation between microstructure and microwave properties, and the effect of selective etching on the overall performance of a thin film-ferroelectric based microwave component, amongst others. We will discuss these issues and will provide an up-dade of the current development status of the reflect-array antenna.

Going Beyond QCD in Lattice Gauge Theory

NASA Astrophysics Data System (ADS)

Fleming, G. T.

2011-01-01

Strongly coupled gauge theories (SCGT's) have been studied theoretically for many decades using numerous techniques. The obvious motivation for these efforts stemmed from a desire to understand the source of the strong nuclear force: Quantum Chromo-dynamics (QCD). Guided by experimental results, theorists generally consider QCD to be a well-understood SCGT. Unfortunately, it is not clear how to extend the lessons learned from QCD to other SCGT's. Particularly urgent motivators for new studies of other SCGT's are the ongoing searches for physics beyond the standard model (BSM) at the Large Hadron Collider (LHC) and the Tevatron. Lattice gauge theory (LGT) is a technique for systematically-improvable calculations in many SCGT's. It has become the standard for non-perturbative calculations in QCD and it is widely believed that it may be useful for study of other SCGT's in the realm of BSM physics. We will discuss the prospects and potential pitfalls for these LGT studies, focusing primarily on the flavor dependence of SU(3) gauge theory.

Holographic rugate structures for x-ray optics applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jannson, T.; Savant, Gajendra.; Qiao, Yong.

1988-07-01

XUV Bragg Holographic Optical Elements (HOEs), based on a single-step volume holographic recording, have been proposed by Physical Optic Corporation (POC), as an entirely new approach to x-ray optics. Their theory, as well as the first experimental proof-of-concept, have been demonstrated in Phase 1 of the DOE program. During the first year (exactly, 8-month duration) of the on-going Phase 2, the high-efficiency XUV Lippmann holographic mirrors have been fabricated and their optical, physical, and material properties have been investigated over the entire XUV region (1--100nm). The XUV Bragg HOEs, based on dichromated gelatin (DCG) and on DCG/polymer grafts, have beenmore » recorded in the visible region (using an Innova Argo laser) and reconstructed using twelve XUV wavelengths. In addition, these phase high-resolution holographic materials have been shown to be suitable to direct x-ray laser holographic recording (using Princeton's x-ray laser). The volume x-ray holographic recording will be realized within the second year of the program effort.« less

A novel management of streptococcal pharyngotonsillar infections by laser-activated silver nanoparticles and methylene blue conjugate, in vitro study.

PubMed

Kassab, Ahmed; Dabous, Ola; Morsy, Mona

2017-09-01

Species of Streptococcus are classified based on their hemolytic properties into alpha and beta types. And, since antimicrobial drug resistance is an increasingly problematic issue, the efforts to develop modalities that would overcome this obstacle and avoid antibiotic side effects is an ongoing challenge. 20 patients from both sexes were selected. The isolated organisms were identified according to standard laboratory methods. Bacterial Cultures were subjected to the low-level diode laser (660 nm), methylene blue (MB) as a photosensitizing agent and for silver nanoparticles. All the experimental groups showed statistically lower values of CFU/ml than the positive control group. The photoactivated MB, silver nanoparticles conjugate showed the maximum inhibitory effect on Streptococci, which opens a gate to further investigation of such a promising protocol to establish a safe and efficient method of management for resistant cases of streptococcal tonsillar infections. Copyright © 2017 Elsevier B.V. All rights reserved.

Automated clinical annotation of tissue bank specimens.

PubMed

Gilbertson, John R; Gupta, Rajnish; Nie, Yimin; Patel, Ashokkumar A; Becich, Michael J

2004-01-01

Modern, molecular bio-medicine is driving a growing demand for extensively annotated tissue bank specimens. With careful clinical, pathologic and outcomes annotation, samples can be better matched to the research question at hand and experimental results better understood and verified. However, the difficulty and expense of detailed specimen annotation is well beyond the capability of most banks and has made access to well documented tissue a major limitation in medical re-search. In this context, we have implemented automated annotation of banked tissue by integrating data from three clinical systems--the cancer registry, the pathology LIS and the tissue bank inventory system--through a classical data warehouse environment. The project required modification of clinical systems, development of methods to identify patients between and map data elements across systems and the creation of de-identified data in data marts for use by researchers. The result has been much more extensive and accurate initial tissue annotation with less effort in the tissue bank, as well as dynamic ongoing annotation as the cancer registry follows patients over time.

Modeling and Characterization of Damage Processes in Metallic Materials

NASA Technical Reports Server (NTRS)

Glaessgen, E. H.; Saether, E.; Smith, S. W.; Hochhalter, J. D.; Yamakov, V. I.; Gupta, V.

2011-01-01

This paper describes a broad effort that is aimed at understanding the fundamental mechanisms of crack growth and using that understanding as a basis for designing materials and enabling predictions of fracture in materials and structures that have small characteristic dimensions. This area of research, herein referred to as Damage Science, emphasizes the length scale regimes of the nanoscale and the microscale for which analysis and characterization tools are being developed to predict the formation, propagation, and interaction of fundamental damage mechanisms. Examination of nanoscale processes requires atomistic and discrete dislocation plasticity simulations, while microscale processes can be examined using strain gradient plasticity, crystal plasticity and microstructure modeling methods. Concurrent and sequential multiscale modeling methods are being developed to analytically bridge between these length scales. Experimental methods for characterization and quantification of near-crack tip damage are also being developed. This paper focuses on several new methodologies in these areas and their application to understanding damage processes in polycrystalline metals. On-going and potential applications are also discussed.

A comparison of WEC control strategies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilson, David G.; Bacelli, Giorgio; Coe, Ryan Geoffrey

2016-04-01

The operation of Wave Energy Converter (WEC) devices can pose many challenging problems to the Water Power Community. A key research question is how to significantly improve the performance of these WEC devices through improving the control system design. This report summarizes an effort to analyze and improve the performance of WEC through the design and implementation of control systems. Controllers were selected to span the WEC control design space with the aim of building a more comprehensive understanding of different controller capabilities and requirements. To design and evaluate these control strategies, a model scale test-bed WEC was designed formore » both numerical and experimental testing (see Section 1.1). Seven control strategies have been developed and applied on a numerical model of the selected WEC. This model is capable of performing at a range of levels, spanning from a fully-linear realization to varying levels of nonlinearity. The details of this model and its ongoing development are described in Section 1.2.« less

Nuclear Thermal Rocket Element Environmental Simulator (NTREES) Phase II Upgrade Activities

NASA Technical Reports Server (NTRS)

Emrich, William J.; Moran, Robert P.; Pearson, J. Bose

2013-01-01

To support the on-going nuclear thermal propulsion effort, a state-of-the-art non nuclear experimental test setup has been constructed to evaluate the performance characteristics of candidate fuel element materials and geometries in representative environments. The facility to perform this testing is referred to as the Nuclear Thermal Rocket Element Environment Simulator (NTREES). This device can simulate the environmental conditions (minus the radiation) to which nuclear rocket fuel components will be subjected during reactor operation. Test articles mounted in the simulator are inductively heated in such a manner so as to accurately reproduce the temperatures and heat fluxes which would normally occur as a result of nuclear fission and would be exposed to flowing hydrogen. Initial testing of a somewhat prototypical fuel element has been successfully performed in NTREES and the facility has now been shutdown to allow for an extensive reconfiguration of the facility which will result in a significant upgrade in its capabilities. Keywords: Nuclear Thermal Propulsion, Simulator

Initial Operation and Shakedown of the Nuclear Thermal Rocket Element Environmental Simulator (NTREES)

NASA Technical Reports Server (NTRS)

Emrich, William J., Jr.

2014-01-01

To support the on-going nuclear thermal propulsion effort, a state-of-the-art non nuclear experimental test setup has been constructed to evaluate the performance characteristics of candidate fuel element materials and geometries in representative environments. The facility to perform this testing is referred to as the Nuclear Thermal Rocket Element Environment Simulator (NTREES). This device can simulate the environmental conditions (minus the radiation) to which nuclear rocket fuel components will be subjected during reactor operation. Prototypical fuel elements mounted in the simulator are inductively heated in such a manner so as to accurately reproduce the temperatures and heat fluxes which would normally occur as a result of nuclear fission in addition to being exposed to flowing hydrogen. Recent upgrades to NTREES now allow power levels 24 times greater than those achievable in the previous facility configuration. This higher power operation will allow near prototypical power densities and flows to finally be achieved in most prototypical fuel elements.

Superconducting Magnets for the 12 GeV Upgrade at Jefferson Lab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fair, Ruben J.; Young, Glenn R.

2015-06-01

Jefferson Laboratory is embarked on an energy upgrade to its flagship continuous electron beam accelerator in order to expand the scope of its research capabilities and probe further into the structure of nuclear particles. The 12 GeV upgrade includes the design, manufacture, integration, installation and commissioning of eight different superconducting magnets in three separate experimental halls. The effort involves other national laboratories, universities and industry spanning three countries. This paper will summarize the key characteristics of these magnets, ranging in size from 0.2 to 23 MJ in stored energy, and featuring many different types and configurations. The paper will alsomore » give an overview of the specific technical challenges for each magnet, and a status report on magnet manufacture and expected delivery dates. The 12GeV upgrade at J-Lab represents the largest superconducting magnet fabrication and installation program currently ongoing in the United States and this paper will present the breadth of collaborations supporting it.« less

Parallel Navier-Stokes computations on shared and distributed memory architectures

NASA Technical Reports Server (NTRS)

Hayder, M. Ehtesham; Jayasimha, D. N.; Pillay, Sasi Kumar

1995-01-01

We study a high order finite difference scheme to solve the time accurate flow field of a jet using the compressible Navier-Stokes equations. As part of our ongoing efforts, we have implemented our numerical model on three parallel computing platforms to study the computational, communication, and scalability characteristics. The platforms chosen for this study are a cluster of workstations connected through fast networks (the LACE experimental testbed at NASA Lewis), a shared memory multiprocessor (the Cray YMP), and a distributed memory multiprocessor (the IBM SPI). Our focus in this study is on the LACE testbed. We present some results for the Cray YMP and the IBM SP1 mainly for comparison purposes. On the LACE testbed, we study: (1) the communication characteristics of Ethernet, FDDI, and the ALLNODE networks and (2) the overheads induced by the PVM message passing library used for parallelizing the application. We demonstrate that clustering of workstations is effective and has the potential to be computationally competitive with supercomputers at a fraction of the cost.

Hungry Horse Dam Fisheries Mitigation, 1992-1993 Progress Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

DosSantos, Joe; Vashro, Jim; Lockard, Larry

1994-06-01

In February of 1900, over forty agency representatives and interested citizens began development of the 1991 Mitigation Plan. This effort culminated in the 1993 Implementation Plan for mitigation of fish losses attributable to the construction and operation of Hungry Horse Dam. The primary purpose of this biennial report is to inform the public of the status of ongoing mitigation activities resulting from those planning efforts. A habitat improvement project is underway to benefit bull trout in Big Creek in the North Fork drainage of the Flathead River and work is planned in Hay Creek, another North Fork tributary. Bull troutmore » redd counts have been expanded and experimental programs involving genetic evaluation, outmigrant monitoring, and hatchery studies have been initiated, Cutthroat mitigation efforts have focused on habitat improvements in Elliott Creek and Taylor`s Outflow and improvements have been followed by imprint plants of hatchery fish and/or eyed eggs in those streams. Rogers Lake west of Kalispell and Lion Lake, near Hungry Horse, were chemically rehabilitated. Cool and warm water fish habitat has been improved in Halfmoon Lake and Echo Lake. Public education and public interest is important to the future success of mitigation activities. As part of the mitigation team`s public awareness responsibility we have worked with numerous volunteer groups, public agencies, and private landowners to stimulate interest and awareness of mitigation activities and the aquatic ecosystem. The purpose of this biennial report is to foster public awareness of, and support for, mitigation activities as we move forward in implementing the Hungry Horse Dam Fisheries Mitigation Implementation Plan.« less

Bias in the reporting of sex and age in biomedical research on mouse models

PubMed Central

Flórez-Vargas, Oscar; Brass, Andy; Karystianis, George; Bramhall, Michael; Stevens, Robert; Cruickshank, Sheena; Nenadic, Goran

2016-01-01

In animal-based biomedical research, both the sex and the age of the animals studied affect disease phenotypes by modifying their susceptibility, presentation and response to treatment. The accurate reporting of experimental methods and materials, including the sex and age of animals, is essential so that other researchers can build on the results of such studies. Here we use text mining to study 15,311 research papers in which mice were the focus of the study. We find that the percentage of papers reporting the sex and age of mice has increased over the past two decades: however, only about 50% of the papers published in 2014 reported these two variables. We also compared the quality of reporting in six preclinical research areas and found evidence for different levels of sex-bias in these areas: the strongest male-bias was observed in cardiovascular disease models and the strongest female-bias was found in infectious disease models. These results demonstrate the ability of text mining to contribute to the ongoing debate about the reproducibility of research, and confirm the need to continue efforts to improve the reporting of experimental methods and materials. DOI: http://dx.doi.org/10.7554/eLife.13615.001 PMID:26939790

Scientific Investigations of Elementary School Children

NASA Astrophysics Data System (ADS)

Valanides, Nicos; Papageorgiou, Maria; Angeli, Charoula

2014-02-01

The study provides evidence concerning elementary school children's ability to conduct a scientific investigation. Two hundred and fifty sixth-grade students and 248 fourth-grade students were administered a test, and based on their performance, they were classified into high-ability and low-ability students. The sample of this study was randomly selected and included 80 students, 40 fourth-grade and 40 sixth-grade students of low and high abilities. Students were specifically instructed to investigate the functioning of a device, to think aloud prior and after any experiment with the device, and to keep a record of their experimental results. The results showed that students were inclined to mainly collect evidence from the experimental space and failed to control variables during their investigation. The majority of the students had difficulties with effectively organizing collected data and failed to coordinate hypotheses with evidence. The significant interaction effect that was found between grade level and ability in terms of students' investigation ability indicates that the existing gap between high- and low-ability students becomes bigger as students become older. Undoubtedly, ongoing research efforts for identifying patterns of children's cognitive development will be most valuable as they can have important implications for the design of teaching scenarios and inquiry-based science activities conducive to accelerating students' cognitive growth and scientific investigation abilities.

Computational simulation of probabilistic lifetime strength for aerospace materials subjected to high temperature, mechanical fatigue, creep and thermal fatigue

NASA Technical Reports Server (NTRS)

Boyce, Lola; Bast, Callie C.; Trimble, Greg A.

1992-01-01

This report presents the results of a fourth year effort of a research program, conducted for NASA-LeRC by the University of Texas at San Antonio (UTSA). The research included on-going development of methodology that provides probabilistic lifetime strength of aerospace materials via computational simulation. A probabilistic material strength degradation model, in the form of a randomized multifactor interaction equation, is postulated for strength degradation of structural components of aerospace propulsion systems subject to a number of effects or primitive variables. These primitive variables may include high temperature, fatigue or creep. In most cases, strength is reduced as a result of the action of a variable. This multifactor interaction strength degradation equation has been randomized and is included in the computer program, PROMISS. Also included in the research is the development of methodology to calibrate the above-described constitutive equation using actual experimental materials data together with regression analysis of that data, thereby predicting values for the empirical material constants for each effect or primitive variable. This regression methodology is included in the computer program, PROMISC. Actual experimental materials data were obtained from industry and the open literature for materials typically for applications in aerospace propulsion system components. Material data for Inconel 718 has been analyzed using the developed methodology.

Computational simulation of probabilistic lifetime strength for aerospace materials subjected to high temperature, mechanical fatigue, creep, and thermal fatigue

NASA Technical Reports Server (NTRS)

Boyce, Lola; Bast, Callie C.; Trimble, Greg A.

1992-01-01

The results of a fourth year effort of a research program conducted for NASA-LeRC by The University of Texas at San Antonio (UTSA) are presented. The research included on-going development of methodology that provides probabilistic lifetime strength of aerospace materials via computational simulation. A probabilistic material strength degradation model, in the form of a randomized multifactor interaction equation, is postulated for strength degradation of structural components of aerospace propulsion systems subjected to a number of effects or primitive variables. These primitive variables may include high temperature, fatigue, or creep. In most cases, strength is reduced as a result of the action of a variable. This multifactor interaction strength degradation equation was randomized and is included in the computer program, PROMISC. Also included in the research is the development of methodology to calibrate the above-described constitutive equation using actual experimental materials data together with regression analysis of that data, thereby predicting values for the empirical material constants for each effect or primitive variable. This regression methodology is included in the computer program, PROMISC. Actual experimental materials data were obtained from industry and the open literature for materials typically for applications in aerospace propulsion system components. Material data for Inconel 718 was analyzed using the developed methodology.

Tomorrow Is Today at Silver Ridge.

ERIC Educational Resources Information Center

Wise, B. J.

1994-01-01

Describes a Washington State school's efforts to forego factory-model education for a boldly restructured curriculum dependent on new technologies, such as computer networks, two-year classrooms, ongoing staff development and planning sessions, and an innovative onsite day-care program for staff and students. The school has succeeded in…

Transforming Schools through Total Quality Education.

ERIC Educational Resources Information Center

Schmoker, Mike; Wilson, Richard B.

1993-01-01

Deming's work emphasizes advantages of teamwork, investment in ongoing training for all employees to increase their value to the company, and insistence that research and employee-gathered data guide and inform every decision and improvement effort. The parallel between psychologist Mihaly Csikszenmihalyi's work and Deming's shows that Total…

Determination of fluorotelomer alcohols in selected consumer products and preliminary investigation of their fate in the indoor environment

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) has established an ongoing effort to identify the major perfluorocarboxylic acid (PFCA) sources in nonoccupational indoor environments and characterize their transport and fate. This study determined the concentrations of perfluorote...

Mass balance and swath displacement evaluations from agricultural application field trials

USDA-ARS?s Scientific Manuscript database

Spray drift is on an ongoing concern for any agricultural application and continues to be the focus for new developments and research efforts dealing with drift reduction technologies, best management application practices and the development of new decision support systems for applicators. Typical...

Climate Change Portal - Home Page

Science.gov Websites

impacts on California's economy and environment. California's unique and valuable natural treasures emissions. Local governments are at the forefront of efforts to adapt to the ongoing and anticipated impacts climate change impacts and informing policies to reduce greenhouse gases, adapt to changing environments

The IEEE Software Engineering Standards Process

PubMed Central

Buckley, Fletcher J.

1984-01-01

Software Engineering has emerged as a field in recent years, and those involved increasingly recognize the need for standards. As a result, members of the Institute of Electrical and Electronics Engineers (IEEE) formed a subcommittee to develop these standards. This paper discusses the ongoing standards development, and associated efforts.

Chapter 1: An Introduction to the Saber-Tooth Project.

ERIC Educational Resources Information Center

Ward, Phillip

1999-01-01

Introduces a theme issue on the Saber-Tooth Project, an ongoing reform effort involving a university and school district that collaborate to improve middle school physical education by improving teaching conditions and engaging teachers in professional development emphasizing curriculum improvement. The monograph explains the nature of…

Reproductive and developmental biology of the emerald ash borer parasitoid Spathius galinae (Hymenoptera: Braconidae) as affected by temperature

USDA-ARS?s Scientific Manuscript database

Emerald ash borer Agrilus planipennis Fairmaire (Coleoptera: Buprestidae) is an invasive pest of serious concern in North America. To complement ongoing biological control efforts, Spathius galinae Belokobylskij and Strazenac (Hymenoptera: Braconidae), a recently-described specialist parasitoid of ...

Ozone Layer Educator's Guide.

ERIC Educational Resources Information Center

Environmental Protection Agency, Washington, DC.

This guide has been developed through a collaborative effort involving the U.S. Environmental Protection Agency (EPA), the National Oceanic and Atmospheric Administration (NOAA), and the National Aeronautics and Space Administration (NASA). It is part of an ongoing commitment to ensure that the results of scientific research on ozone depletion are…

GOALS AND CURRENT RESEARCH OF EPA'S STREAM RESTORATION RESEARCH PROGRAM

EPA Science Inventory

The US EPA is involved in ongoing research on stream and riparian restoration. This presentation is designed to discuss current EPA research efforts, identify key issues in the science and practice of stream restoration, and to help frame a future National Research Council study...

News about Newborn Screening

ERIC Educational Resources Information Center

Exceptional Parent, 2007

2007-01-01

For years "Exceptional Parent" ("EP") has been offering educational information and support to those challenged with disabilities and takes an equally pro-active role in disseminating vital information that could potentially prevent disabilities. This is evidenced by its past and ongoing efforts in being a proponent and champion for comprehensive…

Development of a decision support tool to better manage Alabama's rural public transit vehicles

DOT National Transportation Integrated Search

2000-01-01

In an ongoing effort to improve mobility and quality of life for Alabama's citizens, researchers at the University of Alabama in Huntsville are working to improve the state's ability to manage its rural transit fleet. This fleet management consists o...

The First Attempts to Unionize the Faculty

ERIC Educational Resources Information Center

Cain, Timothy Reese

2010-01-01

Background/Context: Faculty unionization is an important topic in modern higher education, but the history of the phenomenon has not yet been fully considered. This article brings together issues of professionalization and unionization and provides needed historical background to ongoing unionization efforts and debates. Purpose/Objective/Research…

State experiences implementing youth sports concussion laws: challenges, successes, and lessons for evaluating impact.

PubMed

Lowrey, Kerri McGowan; Morain, Stephanie R

2014-01-01

While provisions of youth sports concussion laws are very similar, little is known as to how they are being implemented, factors that promote or impede implementation, or the level of compliance in each jurisdiction. We aimed to describe state experiences with implementation in order to inform ongoing efforts to reduce the harm of sports-related traumatic brain injury and to guide future evaluations of the laws' impacts and the development of future public health laws. We conducted key-informant interviews in 35 states with recently enacted concussion legislation. States varied considerably in their readiness and capacity for implementation. Factors facilitating implementation included existing partnerships, procedures, and resources; centralized implementation authority; prior related efforts; and involvement in the policymaking process by those now charged with implementation. Inhibitors included ambiguous statutory language, unclear delegation of authority, and compliance difficulties. Ongoing challenges persist, including primary prevention; determining which providers are qualified to make return-to-play assessments and contents of those assessments; compliance difficulties in rural and under-served areas; and unclear responsibility for enforcement. Despite the similarity of youth sports concussion laws, early evidence suggests there is considerable variation in their implementation. These findings are critical for ongoing empirical investigations to accurately evaluate the laws' provisions and to identify successful legal approaches to protecting young athletes. © 2014 American Society of Law, Medicine & Ethics, Inc.

Recent progress in MEMS technology development for military applications

NASA Astrophysics Data System (ADS)

Ruffin, Paul B.; Burgett, Sherrie J.

2001-08-01

The recent progress of ongoing efforts at the Army Aviation and Missile Command (AMCOM) to develop microelectromechanical systems (MEMS) technology for military applications is discussed in this paper. The current maturity level of low cost, low power, micro devices in industry, which range from simple temperature and pressure sensors to accelerometers in airbags, provides a viable foundation for the development of rugged MEMS devices for dual-use applications. Early MEMS technology development efforts at AMCOM emphasized inertial MEMS sensors. An Army Science and Technology Objective (STO) project was initiated to develop low cost inertial components with moderate angular rate sensor resolution for measuring pitch and yaw of missile attitude and rotational roll rate. Leveraging the Defense Advanced Research Projects Agency and other Government agencies has resulted in the development of breadboard inertial MEMS devices with improved robustness. During the past two years, MEMS research at AMCOM has been expanded to include environmental MEMS sensors for missile health monitoring, RF-MEMS, optical MEMS devices for beam steering, and micro-optic 'benches' for opto-electronics miniaturization. Additionally, MEMS packaging and integration issues have come into focus and are being addressed. Selected ongoing research efforts in these areas are presented, and some horizon MEMS sensors requirements for Army and law enforcement are presented for consideration.

Nevada National Security Site: Site-Directed Research and Development (SDRD) Fiscal Year 2015 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bender, Howard A.

This report presents results of multiple research projects, new and ongoing, funded under the Site-Directed Research and Development Program for the Nevada National Security Site during federal fiscal year 2015. The Site's legacy capabilities in remote sensing combined with new paradigms for emergency response and consequence management help drive the need to develop advanced aerial sensor platforms. Likewise, dynamic materials science is a critical area of scientific research for which basic physics issues are still unresolved. New methods of characterizing materials in extreme states are vitally needed, and these efforts are paving the way with new knowledge. Projects selected inmore » FY 2015 for the Exploratory Research portfolio exhibit a strong balance of NNSS mission relevance. Geoscience, seismology, and techniques for detecting underground nuclear events are still essential focus areas. Many of the project reports in the second major section of this annual report are ongoing continuations in multi-year lifecycles. Diagnostic techniques for stockpile and nuclear security science figured prominently as well, with a few key efforts coming to fruition, such as phase transition detection. In other areas, modeling efforts toward better understanding plasma focus physics has also started to pay dividends for major program needs.« less

On-Going Laboratory Efforts to Quantitatively Address Clay Abundance on Mars

NASA Technical Reports Server (NTRS)

Roush, Ted L.; Bishop, Janice L.; Brown, Adrian J.; Blake, David F.; Bristow, Thomas F.

2012-01-01

Data obtained at visible and near-infrared wavelengths by OMEGA on MarsExpress and CRISM on MRO provide definitive evidence for the presence of phyllosilicates and other hydrated phases on Mars. A diverse range of both Fe/Mg-OH and Al-OH-bearing phyllosilicates were identified including the smectites, nontronite, saponite, and montmorillonite. In order to constrain the abundances of these phyllosilicates spectral analyses of mixtures are needed. We report on our on-going effort to enable the quantitative evaluation of the abundance of hydrated-hydroxylated silicates when they are contained in mixtures. We include two component mixtures of hydrated/hydroxylated silicates with each other and with two analogs for other martian materials; pyroxene (enstatite) and palagonitic soil (an alteration product of basaltic glass). For the hydrated-hydroxylated silicates we include saponite and montmorillonite (Mg- and Al- rich smectites). We prepared three size separates of each end-member for study: 20-45, 63-90, and 125-150 µm. As the second phase of our effort we used scanning electron microscopy imaging and x-ray diffraction to characterize the grain size distribution, and structural nature, respectively, of the mixtures. Visible and near-infrared reflectance spectra of the 63-90 micrometers grain size of the mixture samples are shown in Figure 1. We discuss the results of our measurements of these mixtures.

Rocketdyne PSAM: In-house enhancement/application

NASA Technical Reports Server (NTRS)

Newell, J. F.; Rajagopal, K. R.; Ohara, K.

1991-01-01

The development was initiated of the Probabilistic Design Analysis (PDA) Process for rocket engines. This will enable engineers a quantitative assessment of calculated reliability during the design process. The PDA will help choose better designs, make them more robust, and help decide on critical tests to help demonstrate key reliability issues to aid in improving the confidence of the engine capabilities. Rockedyne's involvement with the Composite Loads Spectra (CLS) and Probabilistic Structural Analysis Methodology (PSAM) contracts started this effort and are key elements in the on-going developments. Internal development efforts and hardware applications complement and extend the CLS and PSAM efforts. The completion of the CLS option work and the follow-on PSAM developments will also be integral parts of this methodology. A brief summary of these efforts is presented.

Bay in Flux: Marine Climate Impacts, Art and Tablet App Design

NASA Astrophysics Data System (ADS)

Kintisch, E. S.

2012-12-01

Bay in Flux is a year-long experimental effort to design and develop interactive tablet computer apps exploring the marine impacts of climate change. The goal is to convey, visualize and enliven scientific ideas around this topic, while engaging a broad audience through the design of interactive content. Pioneering new models of scientist-artist collaborations are a central part of the effort as well. The project begins with an innovative studio class at the Rhode Island School of Design (RISD) called Bay in Flux, taught in the Fall 2012 semester. Its three instructor team includes two artist-designers and one science reporter, with active collaborations from affiliated marine scientists. The subject matter focus is the Narragansett Bay, which has shown physical, chemical and ecological impacts of climate change, along with the ongoing efforts of researchers to explain and characterize it. In exploring this rich story, we intend to innovate pioneering means of handling narrative material on interactive e-books, enable data collection by citizen scientists or devise game-like simulations to enable audiences to explore and understand complex natural systems. The lessons we seek to learn in this project include: how to effectively encourage collaborations between scientists and designers around digital design; how to pioneer new and compelling ways to tell science-based nonfiction stories on tablets; and how art and design students with no scientific training can engage with complex scientific content effectively. The project will also challenge us to think about the tablet computer not only as a data output device -- in which the user reads, watches, or interacts with provided content -- but also as a dynamic and ideal tool for mobile data input, enabling citizen science projects and novel connections between working researchers and the public. The intended audience could include high school students or older audiences who currently eschew science journalism. HTML5 is the likely language of choice, with the iPad being the initial intended platform. Following the fall class, a spring 2013 effort will involve developing a prototype app. Partners in the Bay in Flux project are the Knight Science Journalism program at MIT, RISD and the National Science Foundation's Rhode Island Experimental Program to Stimulate Competitive Research. Ultimately, the goal is to foster new ways for artists and designers to collaborate with scientists in the environmental field while reaching broad audiences.

Quantifying Silica Reactivity in Subsurface Environments: Reaction Affinity and Solute Matrix Controls on Quartz and SiO2 Glass Dissolution Kinetics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patricia M. Dove

2000-12-13

During the three years of this project, Professor Dove's laboratory made tremendous progress in understanding controls on amorphous silica dissolution kinetics in aqueous solutions. Our findings have already received considerable attention. In hydrothermal and low temperature studies, the work focused on determining quantitative and mechanistic controls on the most abundant silica polymorphs in Earth environments--quartz and amorphous silica. Our studies achieved goals set forth in the original proposal to establish a new quantitative understanding of amorphous silica dissolution. This support has resulted in 10 journal, 12 abstracts and 2 thesis publications. The PI and students were also recognized with 6more » awards during this period. The 1998 EMSP conference in Chicago was an important meeting for our project. The symposium, enabled P.I. Dove to establish valuable contacts with ''users'' having specific needs for the findings of our EMSP project related to the urgency of problems in the Tanks Focus Area (TFA). Since that time, our working relations developed as Dove interacted with TFA scientists and engineers on the problems of waste glass properties. These interactions refined our experimental objectives to better meet their needs. Dove presented the results of EMSP research findings to a TFA subgroup at a Product Acceptance Workshop held in Salt Lake City during December 1998. The travel costs to attend this unanticipated opportunity were paid from EMSP project funds. In January 2000, Dove also attended a similar meeting in Atlanta with PNNL, SRL and BNF scientists/engineers to discuss new issues and make another level of decisions on the Product Acceptance goals. Our EMSP-funded research interfaced very well with the ongoing studies of Dr. Pete McGrail and colleagues in the Applied Geochemistry Group at PNNL. The value of our work to ''users'' was further demonstrated when Dove's EMSP-funded Postdoc, Dr. Jonathan Icenhower was hired by the same PNNL group. With the Icenhower move from postdoc in the Dove lab to a senior scientist position at PNNL, we directly facilitated information transfer from the ''university to user'' environment. Icenhower brought experience in silica-water reactivity and the experimental expertise in high-quality methods of mineral-water reaction kinetics to the PNNL waste clean-up effort. In a further interaction, M.S. student Troy Lorier was hired at the Savannah River Laboratory for a staff position with the Bill Holtzcheiter glass group. His research meshed well with on-going efforts at SRL. In short, our EMSP project went well beyond the academic goals of producing high quality scientific knowledge to establish connections with on-site users to solve problems in TFA. This project also produced new talent for the waste immobilization effort. This EMSP project was highly successful and we thank our sponsors for the opportunity to advance scientific knowledge in this important area of research.« less

Overview of Transonic to Hypersonic Stage Separation Tool Development for Multi-Stage-to-Orbit Concepts

NASA Technical Reports Server (NTRS)

Murphy, Kelly J.; Bunning, Pieter G.; Pamadi, Bandu N.; Scallion, William I.; Jones, Kenneth M.

2004-01-01

An overview of research efforts at NASA in support of the stage separation and ascent aerothermodynamics research program is presented. The objective of this work is to develop a synergistic suite of experimental, computational, and engineering tools and methods to apply to vehicle separation across the transonic to hypersonic speed regimes. Proximity testing of a generic bimese wing-body configuration is on-going in the transonic (Mach numbers 0.6, 1.05, and 1.1), supersonic (Mach numbers 2.3, 3.0, and 4.5) and hypersonic (Mach numbers 6 and 10) speed regimes in four wind tunnel facilities at the NASA Langley Research Center. An overset grid, Navier-Stokes flow solver has been enhanced and demonstrated on a matrix of proximity cases and on a dynamic separation simulation of the bimese configuration. Steady-state predictions with this solver were in excellent agreement with wind tunnel data at Mach 3 as were predictions via a Cartesian-grid Euler solver. Experimental and computational data have been used to evaluate multi-body enhancements to the widely-used Aerodynamic Preliminary Analysis System, an engineering methodology, and to develop a new software package, SepSim, for the simulation and visualization of vehicle motions in a stage separation scenario. Web-based software will be used for archiving information generated from this research program into a database accessible to the user community. Thus, a framework has been established to study stage separation problems using coordinated experimental, computational, and engineering tools.

The Horizon Report. 2006 Edition

ERIC Educational Resources Information Center

New Media Consortium, 2006

2006-01-01

This third edition of the New Media Consortium's (NMC) annual "Horizon Report" describes the continuing work of the Horizon Project, a research-oriented effort that seeks to identify and describe emerging technologies likely to have a large impact on teaching, learning, or creative expression within higher education. Drawing on ongoing discussions…

77 FR 33212 - Notice of FERC Staff Attendance at the Entergy Regional State Committee Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-05

... Gulf States, Louisiana, LLC Docket No. ER11-2133 Entergy Gulf States, Louisiana, LLC Docket No. ER11... Entergy Regional State Committee Meeting The Federal Energy Regulatory Commission (Commission) hereby... the Commission's ongoing outreach efforts. Entergy Regional State Committee Meeting June 6, 2012-June...

Smoothing the Path to Learning Success: A Student Perspective

ERIC Educational Resources Information Center

Doucette, Colleen

2005-01-01

The education system invests time and resources in collaborative processes designed to improve its ability to support students as successful learners. Traditionally, it seeks the advice of educators, researchers, ministries and boards of education, parents, and the public at large in an ongoing effort to increase its effectiveness. Less…

Typology for Parents of Abused Children.

ERIC Educational Resources Information Center

Sloan, Michael P.; Meier, John H.

This paper reports an effort to classify parents of abused children according to existing and new typologies derived from parents' psychopathological personality profiles. Several previously reported typologies for abusive parents are reviewed and elaborated. In addition, reference is given to data and insights gained from an ongoing study of 50…

Prediction of Composition and Emission Characteristics of Articles in Support of Exposure Assessment

EPA Science Inventory

The risk to humans from chemicals in consumer products is dependent on both hazard and exposure. The prediction and quantification of near-field (i.e., indoor) chemical exposure from household articles such as furniture and building materials is an ongoing effort. As opposed to (...

The California Basic Skills Initiative

ERIC Educational Resources Information Center

Illowsky, Barbara

2008-01-01

This article describes the evolution and implementation of the California Basic Skills Initiative (CA BSI), a statewide effort to address ongoing basic skills and ESL needs of community college students and of all campus faculty, administrators, and staff who support these students. CA BSI strategies include assisting every college in assessing…

Nondestructive testing and evaluation of wood : a worldwide research update

Treesearch

Brian K. Brashaw; Voichita Bucur; Ferenc Divos; Raquel Goncalves; Jianxiong Lu; Roger Meder; Roy F. Pellerin; Simon Potter; Robert J Ross; Xiping Wang; Yafang Yin

2009-01-01

The international forest products research community is responding to these driving forces by conducting NDT/NDE research to provide the technologies needed to address these challenges. This article presents a sample of the on-going NDT/NDE research efforts being conducted in several areas of the world.

Photographic Data Extraction Feasibility and Pilot Study in Support of Roadside Safety and Roadway Departure Research

DOT National Transportation Integrated Search

2014-05-01

This work represents the first phase of an ongoing low-cost in-house effort to perform data analysis, optimize internal data gathering in an informed fashion, make data requests to organizations, and obtain needed information. The work also calls on ...

Polymer Day: Outreach Experiments for High School Students

ERIC Educational Resources Information Center

Ting, Jeffrey M.; Ricarte, Ralm G.; Schneiderman, Deborah K.; Saba, Stacey A.; Jiang, Yaming; Hillmyer, Marc A.; Bates, Frank S.; Reineke, Theresa M.; Macosko, Christopher W.; Lodge, Timothy P.

2017-01-01

We present a collection of hands-on experiments that collectively teach precollege students fundamental concepts of polymer synthesis and characterization. These interactive experiments are performed annually as part of an all-day outreach event for high school students that can inform the development of ongoing polymer education efforts in a…

The NMC Horizon Report: 2013 K-12 Edition

ERIC Educational Resources Information Center

Johnson, L.; Adams Becker, S.; Cummins, M.; Estrada V.; Freeman, A.; Ludgate, H.

2013-01-01

"The NMC Horizon Report" series is the most visible outcome of the New Media Consortium (NMC) Horizon Project, an ongoing research effort established in 2002 that identifies and describes emerging technologies likely to have a large impact on teaching, learning, research, or creative expression within education around the globe. This…

Insight and Action Analytics: Three Case Studies to Consider

ERIC Educational Resources Information Center

Milliron, Mark David; Malcolm, Laura; Kil, David

2014-01-01

Civitas Learning was conceived as a community of practice, bringing together forward-thinking leaders from diverse higher education institutions to leverage insight and action analytics in their ongoing efforts to help students learn well and finish strong. We define insight and action analytics as drawing, federating, and analyzing data from…

Homegrown Internationalization: Local Language Diversity as a Resource for Global Educational Initiatives

ERIC Educational Resources Information Center

Crutchfield, Anne

2016-01-01

This case study explored internationalization, diversity, and language through the eyes of students, instructors, and administrators at a multicultural community college in Hawai'i. The purpose was to uncover participants' beliefs and attitudes about ongoing campus-wide internationalization efforts as well as to investigate their broader…

Systematically evaluating read-across prediction and performance using a local validity approach characterized by chemical structure and bioactivity information

EPA Science Inventory

Read-across is a popular data gap filling technique within category and analogue approaches for regulatory purposes. Acceptance of read-across remains an ongoing challenge with several efforts underway for identifying and addressing uncertainties. Here we demonstrate an algorithm...

Premature mortality in the U.S.-- trends by race, ethnicity, age, and region

Cancer.gov

DCEG scientists are spearheading the Premature Mortality Project—an interdisciplinary, multi-institutional effort to characterize U.S. trends in premature mortality. In the process, the team has uncovered distinct mortality trends by race, ethnicity, age, and region, and provided crucial information about the ongoing,

Integration of Fall Prevention into State Policy in Connecticut

ERIC Educational Resources Information Center

Murphy, Terrence E.; Baker, Dorothy I.; Leo-Summers, Linda S.; Bianco, Luann; Gottschalk, Margaret; Acampora, Denise; King, Mary B.

2013-01-01

Purpose of Study: To describe the ongoing efforts of the Connecticut Collaboration for Fall Prevention (CCFP) to move evidence regarding fall prevention into clinical practice and state policy. Methods: A university-based team developed methods of networking with existing statewide organizations to influence clinical practice and state policy.…

Horizon Report: 2010 K-12 Edition

ERIC Educational Resources Information Center

Johnson, L.; Smith, R.; Levine, A.; Haywood, K.

2010-01-01

The "Horizon Report" series is the most visible outcome of the New Media Consortium's Horizon Project, an ongoing research effort established in 2002 that identifies and describes emerging technologies likely to have a large impact on teaching, learning, research, or creative expression within education around the globe. This volume, the "2010…

45 CFR 2516.810 - What types of evaluations are grantees and subgrantees required to perform?

Code of Federal Regulations, 2010 CFR

2010-10-01

... Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE SCHOOL-BASED SERVICE-LEARNING PROGRAMS...? All grantees and subgrantees are required to perform internal evaluations which are ongoing efforts to assess performance and improve quality. Grantees and subgrantees may, but are not required to, arrange...

Managing for Results--Linking Performance Measures and Budgets.

ERIC Educational Resources Information Center

McGee, William L.; Fountain, James R., Jr.

1995-01-01

The Government Accounting Standards Board notion of service efforts and accomplishments reporting is one step in a process of managing for results that includes strategic planning, development and use of performance measures of managing ongoing programs, and outputs to budgetary appropriation. Reports a trial application to one school district.…

Implications of NCLB Accountability for Comprehensive School Reform

ERIC Educational Resources Information Center

Le Floch, Kerstin Carlson; Taylor, James E.; Thomsen, Kerri

2006-01-01

No Child Left Behind (NCLB) accountability mechanisms have the potential to derail comprehensive school reform (CSR) implementation. For those pursuing CSR, the question is how to reconcile the implementation of NCLB accountability mandates with ongoing CSR efforts. Drawing from longitudinal data from a national study of CSR, this article explores…

Teacher Leadership--Connecting Learning to Practice

ERIC Educational Resources Information Center

Coughlan, Margaret

2015-01-01

The Common Core State Standards (CCSS, 2010) as the latest initiative in the ongoing effort of educational reform in the United States reinforces the need to build the capacity of teachers as leaders and change agents. As such, graduate teacher leadership programs function to support and develop teacher leadership praxis. Although studies of…

78 FR 38851 - Electric Reliability Organization Proposal To Retire Requirements in Reliability Standards

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-28

... 215 of the Federal Power Act, the Commission proposes to approve the retirement of 34 requirements... of the Reliability Standards. In addition, the Commission proposes to withdraw 41 outstanding...-Power System. This proposal is part of the Commission's ongoing effort to review its requirements and...

Using Facebook to Support Novice Teachers

ERIC Educational Resources Information Center

Staudt, Denise; St. Clair, Norman; Martinez, Elda E.

2013-01-01

Providing quality support for novice teachers as they enter the profession has been an ongoing concern of educator preparation programs. This article describes the efforts of one teacher preparation program in addressing this matter by utilizing Facebook[R] to provide sustained support and professional development for its beginning teachers. We…

Using Demographics and Statistics To Inform Target Audiences.

ERIC Educational Resources Information Center

Hastings, Janel Henriksen

2000-01-01

Reviews literature that explores the changing role of institutional research in community colleges and its increasing involvement in marketing and institutional advancement activities in two-year colleges. Describes ongoing efforts at a community college in Chicago to identify media resources used most frequently by students, and discusses how the…

WWC Study Review Guide: Group Design Studies

ERIC Educational Resources Information Center

What Works Clearinghouse, 2018

2018-01-01

Underlying all What Works Clearinghouse (WWC) products are WWC Study Review Guides, which are intended for use by WWC certified reviewers to assess studies against the WWC evidence standards. As part of an ongoing effort to increase transparency, promote collaboration, and encourage widespread use of the WWC standards, the Institute of Education…

The Horizon Report. 2004 Edition

ERIC Educational Resources Information Center

New Media Consortium, 2004

2004-01-01

This first edition of the New Media Consortium's (NMC) annual "Horizon Report" details findings of the Horizon Project, a research-oriented effort that seeks to identify and describe emerging technologies likely to have a large impact on teaching, learning, or creative expression within higher education. Drawing on an ongoing series of interviews…

Key Emerging Technologies for Elementary and Secondary Education

ERIC Educational Resources Information Center

Johnson, Laurence F.; Levine, Alan; Smith, Rachel S.; Haywood, Keene

2010-01-01

The Horizon Report series is the most visible outcome of the New Media Consortium's Horizon Project, an ongoing research effort that identifies and describes emerging technologies likely to have a large impact on teaching, learning, research, or creative expression within education around the globe. The report examines emerging technologies for…

Key Emerging Technologies for Elementary and Secondary Education

ERIC Educational Resources Information Center

Johnson, Laurence F.; Levine, Alan; Smith, Rachel S.; Haywood, Keene

2010-01-01

The "Horizon Report" series is the most visible outcome of the New Media Consortium's Horizon Project, an ongoing research effort that identifies and describes emerging technologies likely to have a large impact on teaching, learning, research, or creative expression within education around the globe. The report examines emerging technologies for…

Fans: An Integral Element of the Green Learning Environment

ERIC Educational Resources Information Center

Wolgelenter, Nina

2011-01-01

School districts' ongoing efforts to promote sustainability in America's education facilities are helping raise awareness of social responsibility and promoting the positive effects that greening their learning environments has on the general health and productivity of students. One institution that's taking the lead in this movement is Chandler…

WATERSHED CHARACTERISTICS AND PRE-RESTORATION SURFACE-WATER HYDROLOGY OF MINEBANK RUN, BALTIMORE COUNTY, MARYLAND, WATER YEARS 2002-04

EPA Science Inventory

Stream restoration efforts have been ongoing in Maryland since the early 1990s. Physical stream restoration often involves replacement of lost sediments to elevate degraded streambeds, re-establishment of riffle-pool sequences along the channel profile, planting vegetation in rip...

Mentoring: A New Approach to Geography Teacher Preparation

ERIC Educational Resources Information Center

Bednarz, Sarah Witham; Bockenhauer, Mark H.; Walk, Fred H.

2005-01-01

Geography teacher preparation is an ongoing problem for the discipline. Changes in certification requirements and federal and state educational policies have diminished the role of colleges and universities in educating teachers. At the same time, geography education reform efforts have resulted in higher standards and an increased quantity of…

76 FR 62804 - Notice of FERC Staff Attendance at the Entergy Regional State Committee Work Group and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-11

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of FERC Staff Attendance at the Entergy Regional State Committee Work Group and Stakeholder Meeting The Federal Energy Regulatory... is part of the Commission's ongoing outreach efforts. Entergy Regional State Committee Work Group and...

Selected Syllabi for Infusing Career Education into College and University Courses.

ERIC Educational Resources Information Center

Dunbar, Zola, Ed.

The infusion of career education concepts into college and university courses is documented by this collection of twenty college course syllabi developed to facilitate the ongoing efforts of Oregon's colleges and universities in preparing educational personnel for the development and conduct of career education activities. These twenty syllabi…

Building Inclusive Engineering Identities: Implications for Changing Engineering Culture

ERIC Educational Resources Information Center

Atadero, Rebecca A.; Paguyo, Christina H.; Rambo-Hernandez, Karen E.; Henderson, Heather L.

2018-01-01

Ongoing efforts to broaden the participation of women and people of colour in engineering degree programmes and careers have had limited success. This paper describes a different approach to broadening participation that seeks to work with all students and develop inclusive engineering identities. Researchers worked with the instructors of two…

76 FR 60385 - Privacy Act of 1974: Implementation of Exemptions; Department of Homeland Security U.S...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-29

... for Disclosures) because release of the accounting of disclosures could alert the subject of an... efforts to preserve national security. Disclosure of the accounting would also permit the individual who... ongoing law enforcement, national security or fraud investigation; to avoid disclosure of investigative...

Strategies for monitoring terrestrial animals and habitats

Treesearch

Richard Holthausen; Raymond L. Czaplewski; Don DeLorenzo; Greg Hayward; Winifred B. Kessler; Pat Manley; Kevin S. McKelvey; Douglas S. Powell; Leonard F. Ruggiero; Michael K. Schwartz; Bea Van Horne; Christina D. Vojta

2005-01-01

This General Technical Report (GTR) addresses monitoring strategies for terrestrial animals and habitats. It focuses on monitoring associated with National Forest Management Act planning and is intended to apply primarily to monitoring efforts that are broader than individual National Forests. Primary topics covered in the GTR are monitoring requirements; ongoing...

(Re)constructing Ideals of Multicultural Education through "Grow Your Own Teachers"

ERIC Educational Resources Information Center

Madda, Christina L.; Schultz, Brian D.

2009-01-01

Reflecting on the current status of multicultural education in higher education institutions, we examine "Grow Your Own Teachers," a progressive, innovative program that not only embodies and enacts major principles of multicultural education, but also represents an ongoing effort to redefine and revitalize multicultural education within…

The Research Funding Guidebook: Getting It, Managing It, and Renewing It.

ERIC Educational Resources Information Center

Ries, Joanne B.; Leukefeld, Carl G.

This guide, intended primarily for new or inexperienced researchers, provides suggestions for obtaining and maintaining external funding from grants and contracts. It emphasizes that this effort requires considerable thought, ongoing planning, sound management, and clear decisions. The book uses the National Institutes of Health application and…

Developing a Successful Asynchronous Online Extension Program for Forest Landowners

ERIC Educational Resources Information Center

Zobrist, Kevin W.

2014-01-01

Asynchronous online Extension classes can reach a wide audience, is convenient for the learner, and minimizes ongoing demands on instructor time. However, producing such classes takes significant effort up front. Advance planning and good communication with contributors are essential to success. Considerations include delivery platforms, content…

Common Ground: A Way of Life, Not a Checkoff Item.

ERIC Educational Resources Information Center

Ledell, Marjorie A.

1996-01-01

The common ground process is an ongoing effort for inviting, scrutinizing, debating, and selecting ideas or making decisions about improving schools. Superintendents should assign a full-time communications person to executive staff, create a communications team, conduct a full-scale communications audit, listen better, urge the silent majority to…

28 CFR 16.132 - Exemption of Department of Justice System-Personnel Investigation and Security Clearance Records...

Code of Federal Regulations, 2010 CFR

2010-07-01

...) Subsection (d)(2). Amendment of the records could interfere with ongoing criminal or civil law enforcement... actual or potential law enforcement or counterintelligence investigation, and thereby seriously impede law enforcement or counterintelligence efforts by permitting the record subject and other persons to...

28 CFR 16.132 - Exemption of Department of Justice System-Personnel Investigation and Security Clearance Records...

Code of Federal Regulations, 2012 CFR

2012-07-01

...) Subsection (d)(2). Amendment of the records could interfere with ongoing criminal or civil law enforcement... actual or potential law enforcement or counterintelligence investigation, and thereby seriously impede law enforcement or counterintelligence efforts by permitting the record subject and other persons to...

28 CFR 16.132 - Exemption of Department of Justice System-Personnel Investigation and Security Clearance Records...

Code of Federal Regulations, 2011 CFR

2011-07-01

...) Subsection (d)(2). Amendment of the records could interfere with ongoing criminal or civil law enforcement... actual or potential law enforcement or counterintelligence investigation, and thereby seriously impede law enforcement or counterintelligence efforts by permitting the record subject and other persons to...

28 CFR 16.132 - Exemption of Department of Justice System-Personnel Investigation and Security Clearance Records...

Code of Federal Regulations, 2014 CFR

2014-07-01

...) Subsection (d)(2). Amendment of the records could interfere with ongoing criminal or civil law enforcement... actual or potential law enforcement or counterintelligence investigation, and thereby seriously impede law enforcement or counterintelligence efforts by permitting the record subject and other persons to...

28 CFR 16.132 - Exemption of Department of Justice System-Personnel Investigation and Security Clearance Records...

Code of Federal Regulations, 2013 CFR

2013-07-01

...) Subsection (d)(2). Amendment of the records could interfere with ongoing criminal or civil law enforcement... actual or potential law enforcement or counterintelligence investigation, and thereby seriously impede law enforcement or counterintelligence efforts by permitting the record subject and other persons to...

Lessons Learned: The Evolution of an Undergraduate Research Program

ERIC Educational Resources Information Center

Smith, Gregory; Laker, Lauren; Tesch, Debbie

2013-01-01

Undergraduate research programs are commonplace at many universities. However, little research has been conducted to evaluate their ongoing and long-term effectiveness from the standpoint of the undergraduate student researcher. In an effort to gain perspective from the student researcher, including their thoughts on such a program, a survey was…

77 FR 55429 - Fitness-for-Duty Programs

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-10

...-2009-0090] RIN 3150-AI58 Fitness-for-Duty Programs AGENCY: Nuclear Regulatory Commission. ACTION... ongoing proposed rulemaking effort to amend its regulations regarding Fitness-for-Duty Programs. The NRC... portions of part 26 of Title 10 of the Code of Federal Regulations (10 CFR), ``Fitness-for-Duty Programs...

SOME QUANTITATIVE ASPECTS OF THE INSTRUCTIONAL PROCESS.

ERIC Educational Resources Information Center

GAVIN, WILLIAM J.; SPITZER, MURRAY

THE DATA FROM THE SEVERAL STUDIES ANALYZED IN THIS REPORT HAVE BEEN COLLECTED AS PART OF AN ON-GOING EFFORT TO IMPLEMENT THE ABT ASSOCIATES' EDUCATION COST EFFECTIVENESS INSTRUCTIONAL PROCESS SUBMODEL, WHICH IS DEVELOPING TECHNIQUES TO EVALUATE THE QUANTITATIVE, CAUSE-AND-EFFECT RELATIONSHIP BETWEEN THE INSTRUCTIONAL PROCESS AND SCHOLASTIC…

The Horizon Report. 2005 Edition

ERIC Educational Resources Information Center

New Media Consortium, 2005

2005-01-01

This second edition of the New Media Consortium's (NMC) annual "Horizon Report" describes the continuing work of the Horizon Project, a research-oriented effort that seeks to identify and describe emerging technologies likely to have a large impact on teaching, learning, or creative expression within higher education. Drawing on an ongoing series…

Transcriptome assembly, gene annotation and tissue gene expression atlas of the rainbow trout

USDA-ARS?s Scientific Manuscript database

Efforts to obtain a comprehensive genome sequence for rainbow trout are ongoing and will be complimented by transcriptome information that will enhance genome assembly and annotation. Previously, we reported a transcriptome reference sequence using a 19X coverage of Sanger and 454-pyrosequencing dat...

Ensuring the Ongoing Engagement of Second-Stage Teachers

ERIC Educational Resources Information Center

Kirkpatrick, Cheryl L.; Johnson, Susan Moore

2014-01-01

Research and policy have increasingly focused on the importance of staffing schools with effective teachers. A critical variable affecting teacher effectiveness is the enthusiasm, energy and effort teachers bring to their work, or teachers' work engagement. Better understanding teachers' work engagement and how it may change over stages…

Trailblazing Partnerships: Professional Development Schools in Partnership with Emporia State University

ERIC Educational Resources Information Center

Jones, Jill; Schwerdtfeger, Sara; Roop, Teddy; Long, Jennie L.

2016-01-01

Emporia State University is committed to preparing future elementary education teachers through the collaborative efforts and ongoing reflective practice between the university and school districts. The Professional Development School is the vehicle behind the structured involvement in the process of immersing student-teacher in a clinical model…

The Offshore Model for Universities

ERIC Educational Resources Information Center

Ross, Andrew

2008-01-01

This article discusses the ongoing effort of the World Trade Organization (WTO) to bring higher education services within the purview of the General Agreement on Trade and Services (GATS). One result of the anticipated liberalization of trade in education, the author explains, is the headlong rush of Anglophone universities into the global market…

Socio-Economic Impact Assessment of the Computerized Customer Information System (CCIS) at the Southern California Rapid Transit District (SCRTD)

DOT National Transportation Integrated Search

1983-06-01

This document is a product of an ongoing program to assess the impacts of automated transit information system (ATIS) technology on the transit industry's efforts to improve the productivity and quality of telephone information/marketing services to ...

The NMC Horizon Report: 2015 Higher Education Edition

ERIC Educational Resources Information Center

Johnson, L.; Adams Becker, S.; Estrada, V.; Freeman, A.

2015-01-01

The "NMC Horizon Report: 2015 Higher Education Edition" is a collaborative effort between the New Media Consortium (NMC) and the EDUCAUSE Learning Initiative (ELI). This 12th edition describes annual findings from the NMC Horizon Project, an ongoing research project designed to identify and describe emerging technologies likely to have…

The Strategic Assessment Model.

ERIC Educational Resources Information Center

Glazner, Steve, Ed.

This book presents six papers focusing on the application of the strategic assessment model (SAM) to the management of higher education facilities. The papers are part of an ongoing effort by the Association of Higher Education Facilities Officers to provide comparative cost and staffing information and to develop a benchmarking process. The…

Community Organizing: Strategies for Recruitment and Retention.

ERIC Educational Resources Information Center

Reyes, Reva Crawford

This book summarizes the role of community organizing principles in a successful adult education program serving Native American adults. Gleaned from workshops conducted by two Cherokees who have been highly successful in their own community organizing efforts, from ongoing staff discussion, and from years of practical experiences of program…

EVALUATION OF THE LEVELS OF DIOXIN-LIKE COMPOUNDS IN ANIMAL FEEDS

EPA Science Inventory

The purpose of this study is to measure the levels of dioxin-like compounds in the feeds of terrestrial food animals - cattle, swine, and poultry - and to understand their contribution to the dioxin-like levels found in the animals. It is an ongoing effort involving several phase...

76 FR 65191 - California Independent System Operator Corporation; Notice of FERC Staff Attendance

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-20

...; Notice of FERC Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that on the following dates members of its staff will participate in teleconferences and meetings to be... staff's attendance is part of the Commission's ongoing outreach efforts. The teleconferences and...

28 CFR 91.58 - Timing of the environmental review process.

Code of Federal Regulations, 2010 CFR

2010-07-01

... decisions or new commitments of resources can be made on these projects by the State or local entity that... specifications; or (5) Purchasing property. (e) Ongoing or completed construction projects. For grant-funded... been done, making every effort to limit disruption to projects under construction. For completed grant...

Train-to-Train Impact Test of Crash-Energy Management Passenger Rail Equipment: Occupant Experiments

DOT National Transportation Integrated Search

2006-11-06

As part of an ongoing passenger rail crashworthiness effort, : a full-scale impact test of a train with crash energy management : (CEM) passenger cars was conducted on March 23, 2006. In : this test, a train made up of a CEM cab car, four CEM coach :...

Trophic Structure Over the Northern Mid-Atlantic Ridge: The Bathypelagic Zone Really Matters

EPA Science Inventory

We present preliminary results and ongoing efforts to characterize the trophic structure and energy flow of the pelagic ecosystems of the northern Mid-Atlantic Ridge (MAR), from Iceland to the Azores. This study is one component of the international CoML field project MAR-ECO (ww...

Restorative Justice: Pedagogy, Praxis, and Discipline

ERIC Educational Resources Information Center

Morrison, Brenda E.; Vaandering, Dorothy

2012-01-01

In the ongoing effort of designing school contexts in support of proactive discipline, a range of practices and theoretical frameworks have been advanced, from behaviorist approaches to social and emotional learning. This article describes the theory and practice of restorative justice with the aim of defining this distinctive paradigm, in…

Advanced Solar Cell Testing and Characterization

NASA Technical Reports Server (NTRS)

Bailey, Sheila; Curtis, Henry; Piszczor, Michael

2005-01-01

The topic for this workshop stems from an ongoing effort by the photovoltaic community and U.S. government to address issues and recent problems associated with solar cells and arrays experienced by a number of different space systems. In April 2003, a workshop session was held at the Aerospace Space Power Workshop to discuss an effort by the Air Force to update and standardize solar cell and array qualification test procedures in an effort to ameliorate some of these problems. The organizers of that workshop session thought it was important to continue these discussions and present this information to the entire photovoltaic community. Thus, it was decided to include this topic as a workshop at the following SPRAT conference.

On the design of script languages for neural simulation.

PubMed

Brette, Romain

2012-01-01

In neural network simulators, models are specified according to a language, either specific or based on a general programming language (e.g. Python). There are also ongoing efforts to develop standardized languages, for example NeuroML. When designing these languages, efforts are often focused on expressivity, that is, on maximizing the number of model types than can be described and simulated. I argue that a complementary goal should be to minimize the cognitive effort required on the part of the user to use the language. I try to formalize this notion with the concept of "language entropy", and I propose a few practical guidelines to minimize the entropy of languages for neural simulation.

Final Report of the Mid-Atlantic Marine Wildlife Surveys, Modeling, and Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saracino-Brown, Jocelyn; Smith, Courtney; Gilman, Patrick

The Wind Program hosted a two-day workshop on July 24-25, 2012 with scientists and regulators engaged in marine ecological survey, modeling, and database efforts pertaining to the waters of the Mid-Atlantic region. The workshop was planned by Federal agency, academic, and private partners to promote collaboration between ongoing offshore ecological survey efforts, and to promote the collaborative development of complementary predictive models and compatible databases. The meeting primarily focused on efforts to establish and predict marine mammal, seabird, and sea turtle abundance, density, and distributions extending from the shoreline to the edge of the Exclusive Economic Zone between Nantucket Sound,more » Massachusetts and Cape Hatteras, North Carolina.« less

Gravitational waves in axion inflation: implications for CMB and small-scales interferometer measurements

NASA Astrophysics Data System (ADS)

Unal, Caner; Peloso, Marco; Sorbo, Lorenzo; Garcia-Bellido, Juan

2017-01-01

A strong experimental effort is ongoing to detect the primordial gravitational waves (GW) generated during inflation from their impact on the Cosmic Microwave Background (CMB). This effort is motivated by the direct relation between the amplitude of GW signal and the energy scale of inflation, in the standard case of GW production from vacuum. I will discuss the robustness of this relation and the conditions under which particle production mechanisms during inflation can generate a stronger GW signal than the vacuum one. I will present a concrete model employing a coupling between a rolling axion and a gauge field, that can produce a detectable GW signal for an arbitrarily small inflation scale, respecting bounds from back-reaction, perturbativity, and the gaussianity of the measured density perturbations. I will show how the GW produced by this mechanism can be distinguished from the vacuum ones by their spectral dependence and statistical properties. I will finally discuss the possibility of detecting an inflationary GW signal at terrestrial (AdvLIGO) and space (LISA) interferometers. Such experiments are sensitive to the modes much smaller than the ones corresponding to CMB and Large Scale Structure, presenting a unique observational window on the final stages of inflation. The work of C.U. is s supported by a Doctoral Dissertation Fellowship from the Graduate School of the University of Minnesota.

Nanotechnology research: applications in nutritional sciences.

PubMed

Srinivas, Pothur R; Philbert, Martin; Vu, Tania Q; Huang, Qingrong; Kokini, Josef L; Saltos, Etta; Saos, Etta; Chen, Hongda; Peterson, Charles M; Friedl, Karl E; McDade-Ngutter, Crystal; Hubbard, Van; Starke-Reed, Pamela; Miller, Nancy; Betz, Joseph M; Dwyer, Johanna; Milner, John; Ross, Sharon A

2010-01-01

The tantalizing potential of nanotechnology is to fabricate and combine nanoscale approaches and building blocks to make useful tools and, ultimately, interventions for medical science, including nutritional science, at the scale of approximately 1-100 nm. In the past few years, tools and techniques that facilitate studies and interventions in the nanoscale range have become widely available and have drawn widespread attention. Recently, investigators in the food and nutrition sciences have been applying the tools of nanotechnology in their research. The Experimental Biology 2009 symposium entitled "Nanotechnology Research: Applications in Nutritional Sciences" was organized to highlight emerging applications of nanotechnology to the food and nutrition sciences, as well as to suggest ways for further integration of these emerging technologies into nutrition research. Speakers focused on topics that included the problems and possibilities of introducing nanoparticles in clinical or nutrition settings, nanotechnology applications for increasing bioavailability of bioactive food components in new food products, nanotechnology opportunities in food science, as well as emerging safety and regulatory issues in this area, and the basic research applications such as the use of quantum dots to visualize cellular processes and protein-protein interactions. The session highlighted several emerging areas of potential utility in nutrition research. Nutrition scientists are encouraged to leverage ongoing efforts in nanomedicine through collaborations. These efforts could facilitate exploration of previously inaccessible cellular compartments and intracellular pathways and thus uncover strategies for new prevention and therapeutic modalities.

Advanced imaging of tau pathology in Alzheimer Disease: New perspectives from super resolution microscopy and label-free nanoscopy.

PubMed

Schierle, Gabriele S Kaminski; Michel, Claire H; Gasparini, Laura

2016-08-01

Alzheimer's disease (AD) is the main cause of dementia in the elderly population. Over 30 million people worldwide are living with dementia and AD prevalence is projected to increase dramatically in the next two decades. In terms of neuropathology, AD is characterized by two major cerebral hallmarks: extracellular β-amyloid (Aβ) plaques and intracellular Tau inclusions, which start accumulating in the brain 15-20 years before the onset of symptoms. Within this context, the scientific community worldwide is undertaking a wide research effort to detect AD pathology at its earliest, before symptoms appear. Neuroimaging of Aβ by positron emission tomography (PET) is clinically available and is a promising modality for early detection of Aβ pathology and AD diagnosis. Substantive efforts are ongoing to develop advanced imaging techniques for early detection of Tau pathology. Here, we will briefly describe the key features of Tau pathology and its heterogeneity across various neurodegenerative diseases bearing cerebral Tau inclusions (i.e., tauopathies). We will outline the current status of research on Tau-specific PET tracers and their clinical development. Finally, we will discuss the potential application of novel super-resolution and label-free techniques for investigating Tau pathology at the experimental level and their potential application for AD diagnosis. Microsc. Res. Tech. 79:677-683, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Nanotechnology Research: Applications in Nutritional Sciences12

PubMed Central

Srinivas, Pothur R.; Philbert, Martin; Vu, Tania Q.; Huang, Qingrong; Kokini, Josef L.; Saos, Etta; Chen, Hongda; Peterson, Charles M.; Friedl, Karl E.; McDade-Ngutter, Crystal; Hubbard, Van; Starke-Reed, Pamela; Miller, Nancy; Betz, Joseph M.; Dwyer, Johanna; Milner, John; Ross, Sharon A.

2010-01-01

The tantalizing potential of nanotechnology is to fabricate and combine nanoscale approaches and building blocks to make useful tools and, ultimately, interventions for medical science, including nutritional science, at the scale of ∼1–100 nm. In the past few years, tools and techniques that facilitate studies and interventions in the nanoscale range have become widely available and have drawn widespread attention. Recently, investigators in the food and nutrition sciences have been applying the tools of nanotechnology in their research. The Experimental Biology 2009 symposium entitled “Nanotechnology Research: Applications in Nutritional Sciences” was organized to highlight emerging applications of nanotechnology to the food and nutrition sciences, as well as to suggest ways for further integration of these emerging technologies into nutrition research. Speakers focused on topics that included the problems and possibilities of introducing nanoparticles in clinical or nutrition settings, nanotechnology applications for increasing bioavailability of bioactive food components in new food products, nanotechnology opportunities in food science, as well as emerging safety and regulatory issues in this area, and the basic research applications such as the use of quantum dots to visualize cellular processes and protein-protein interactions. The session highlighted several emerging areas of potential utility in nutrition research. Nutrition scientists are encouraged to leverage ongoing efforts in nanomedicine through collaborations. These efforts could facilitate exploration of previously inaccessible cellular compartments and intracellular pathways and thus uncover strategies for new prevention and therapeutic modalities. PMID:19939997

GAPP: A Proteogenomic Software for Genome Annotation and Global Profiling of Post-translational Modifications in Prokaryotes.

PubMed

Zhang, Jia; Yang, Ming-Kun; Zeng, Honghui; Ge, Feng

2016-11-01

Although the number of sequenced prokaryotic genomes is growing rapidly, experimentally verified annotation of prokaryotic genome remains patchy and challenging. To facilitate genome annotation efforts for prokaryotes, we developed an open source software called GAPP for genome annotation and global profiling of post-translational modifications (PTMs) in prokaryotes. With a single command, it provides a standard workflow to validate and refine predicted genetic models and discover diverse PTM events. We demonstrated the utility of GAPP using proteomic data from Helicobacter pylori, one of the major human pathogens that is responsible for many gastric diseases. Our results confirmed 84.9% of the existing predicted H. pylori proteins, identified 20 novel protein coding genes, and corrected four existing gene models with regard to translation initiation sites. In particular, GAPP revealed a large repertoire of PTMs using the same proteomic data and provided a rich resource that can be used to examine the functions of reversible modifications in this human pathogen. This software is a powerful tool for genome annotation and global discovery of PTMs and is applicable to any sequenced prokaryotic organism; we expect that it will become an integral part of ongoing genome annotation efforts for prokaryotes. GAPP is freely available at https://sourceforge.net/projects/gappproteogenomic/. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

The PLAID graphics analysis impact on the space program

NASA Technical Reports Server (NTRS)

Nguyen, Jennifer P.; Wheaton, Aneice L.; Maida, James C.

1994-01-01

An ongoing project design often requires visual verification at various stages. These requirements are critically important because the subsequent phases of that project might depend on the complete verification of a particular stage. Currently, there are several software packages at JSC that provide such simulation capabilities. We present the simulation capabilities of the PLAID modeling system used in the Flight Crew Support Division for human factors analyses. We summarize some ongoing studies in kinematics, lighting, EVA activities, and discuss various applications in the mission planning of the current Space Shuttle flights and the assembly sequence of the Space Station Freedom with emphasis on the redesign effort.

TOLUENE EXPERIMENTAL EXPOSURES IN HUMANS: PHARMACOKINETICS AND BEHAVIOR

EPA Science Inventory

Toluene Experimental Exposures in Humans:
Pharmacokinetics and Behavioral Effects
(Ongoing Research)

Vernon A. Benignus1, Philip J. Bushnell2 and William K. Boyes2

Human subjects will be exposed to 250 and 500 ppm toluene for one hour in the Human St...

Westinghouse programs in pulsed homopolar power supplies

NASA Technical Reports Server (NTRS)

Litz, D. C.; Mullan, E.

1984-01-01

This document details Westinghouse's ongoing study of homopolar machines since 1929 with the major effort occurring in the early 1970's to the present. The effort has enabled Westinghouse to develop expertise in the technology required for the design, fabrication and testing of such machines. This includes electrical design, electromagnetic analysis, current collection, mechanical design, advanced cooling, stress analysis, transient rotor performance, bearing analysis and seal technology. Westinghouse is using this capability to explore the use of homopolar machines as pulsed power supplies for future systems in both military and commercial applications.

Employment of individuals in the Social Security disability programs.

PubMed

O'Leary, Paul; Livermore, Gina A; Stapleton, David C

2011-01-01

The articles in this special issue present findings from research on the employment and work-related activities of individuals receiving benefits through the Social Security Disability Insurance and Supplemental Security Income programs, and on the factors that hinder their efforts to work at levels that lead to exiting the disability rolls. This article introduces the other articles, highlights their important findings, and discusses the implications for ongoing efforts to increase the earnings and self-sufficiency of these beneficiaries, such as the Ticket to Work program and the Benefit Offset National Demonstration.

Tracking Learners' Progress: Adopting a Dual "Corpus cum Experimental Data" Approach

ERIC Educational Resources Information Center

Meunier, Fanny; Littre, Damien

2013-01-01

The article discusses the potential of combining learner corpus research with experimental studies in order to fine-tune the understanding of learner language development. It illustrates the complementarity of the two methodological approaches with data from an ongoing study of the acquisition of the English tense and aspect system by French…

Inertial confinement fusion for energy: overview of the ongoing experimental, theoretical and numerical studies

NASA Astrophysics Data System (ADS)

Jacquemot, S.

2017-10-01

This paper provides an overview of the results presented at the 26th IAEA Fusion Energy Conference in the field of inertial confinement fusion for energy, covering its various experimental, numerical/theoretical and technological facets, as well as the different paths towards ignition that are currently followed worldwide.

AASA Survey: Impact of the Economic Downturn on School Jobs

ERIC Educational Resources Information Center

AASA, The School Superintendent's Association, 2009

2009-01-01

As part of an ongoing effort to gauge how school districts across the country are responding to the current economic downturn, the American Association of School Administrators (AASA) continues to assess various measures of economic impact. Earlier AASA surveys addressed trends in districts' initial responses to the downturn, districts'…

A Characterization of Individual Differences in Prospective Memory Monitoring Using the Complex Ongoing Serial Task

ERIC Educational Resources Information Center

Savine, Adam C.; McDaniel, Mark A.; Shelton, Jill Talley; Scullin, Michael K.

2012-01-01

Prospective memory--remembering to retrieve and execute future goals--is essential to daily life. Prospective remembering is often achieved through effortful monitoring; however, potential individual differences in monitoring patterns have not been characterized. We propose 3 candidate models to characterize the individual differences present in…

Yavapai College Student Satisfaction Survey Conducted December 2002.

ERIC Educational Resources Information Center

Yavapai Coll., Prescott, AZ.

Yavapai College, Arizona, conducted a telephone survey of current college students in December 2002. The survey provides data for future marketing efforts, as well as providing information to be used as part of an ongoing assessment of student opinions and needs. An independent telemarketing firm called students from a random list of 1,400 credit…

Community Chairs as a Catalyst for Campus Collaborations in STEM

ERIC Educational Resources Information Center

Grandgenett, Neal; Edick, Nancy; Boocker, Dave; Ali, Hesham; Hodge, Angie; Dorn, Brian; Cutucache, Christine

2015-01-01

Strong collaborative partnerships are critical to the ongoing success of any urban or metropolitan university in its efforts to build the science, technology, engineering, and mathematics (STEM) career pathways so critical to our nation. At the University of Nebraska at Omaha, we have established a faculty leadership structure of "community…

A Study of Perceived Admission and Achievement Barriers of Learning-Disabled Students in Postsecondary Institutions

ERIC Educational Resources Information Center

Lamberg, Catherine Denise

2012-01-01

Learning-disabled students face ongoing challenges in higher education. Despite efforts to promote recruitment and retention of students with learning disabilities to trade schools, colleges, and universities, barriers to enrollment and academic achievement persist. Barriers for learning-disabled students are not fully understood and might be…

Louisiana Standards for Programs Serving Four-Year-Old Children: Bulletin.

ERIC Educational Resources Information Center

Picard, Cecil J.

As part of Louisiana's efforts to expand and improve the quality of its early childhood programs, a committee of educators from across the state collaborated to develop standards for programs serving 4-year-olds. This guide presents program standards to assist the ongoing development, evaluation, and improvement of early childhood center-based…

Social Determinants of Educational Outcomes in Indigenous Learners

ERIC Educational Resources Information Center

Chandler, Michael J.

2010-01-01

For the better part of two decades, the author and his research colleagues have been engaged in a broad program of research aimed at identifying certain of the "social determinants of health and wellbeing" common to Canadian First Nation, Metis, and Inuit youth. The present account samples from these ongoing research efforts by recapping…

The California Wildlife/Fish Habitat Relationship System

Treesearch

William E. Grenfell; Hal Salwasser; William F. Laudenslayer

1982-01-01

The California Wildlife/Fish Habitat Relationships (WFHR) System is an ongoing effort to apply our knowledge of wildlife habitat requirements to identify and explain the consequences of proposed land use activities, particularly those activities that affect vegetation. The U.S. Forest Service initiated the WFHR program in California in 1976 and has developed it for all...

75 FR 69086 - Submission for OMB review; comment request; NCCAM Office of Communications and Public Liaison...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-10

...) formative and (2) evaluative research of a variety of print and online materials, outreach activities, and... evaluative research on existing materials and messages, as part of OCPL's ongoing effort to develop a comprehensive program of testing and evaluation of all of its communications strategies. This evaluative...

75 FR 61763 - Submission for OMB Review; Comment Request; NCCAM Office of Communications and Public Liaison...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-06

...) formative and (2) evaluative research of a variety of print and online materials, outreach activities, and... evaluative research on existing materials and messages, as part of OCPL's ongoing effort to develop a comprehensive program of testing and evaluation of all of its communications strategies. This evaluative...

Biological Effects–Based Tools for Monitoring Impacted Surface Waters in the Great Lakes: A Multiagency Program in Support of the Great Lakes Restoration Initiative

EPA Science Inventory

There is increasing demand for the implementation of effects-based monitoring and surveillance (EBMS) approaches in the Great Lakes Basin to complement traditional chemical monitoring. Herein, we describe an ongoing multiagency effort to develop and implement EBMS tools, particul...

Potential for extending major land resource areas into northern Mexico

Treesearch

Roy S. Mann; Philip Heilman; Jeffry Stone

2013-01-01

There is a significant history of cooperative efforts between Mexico and the United States on natural resource management issues. Mexico and the United States have jointly conducted research and developed range management technologies. Bringing these technologies together and improving technical communications are an ongoing process. This paper discusses a potential...

Partnerships and volunteers in the U.S. Forest Service

Treesearch

James D. Absher

2009-01-01

The U.S. Forest Service often relies on volunteers and partnerships to help accomplish agency goals, particularly in its recreation and heritage programs. Data from agency records and a staff survey suggest that volunteer involvement is a developing area. Ongoing efforts to improve the agency's volunteer management capacity (VMC) would benefit from more attention...

Overview of NASA Cryocooler Programs

NASA Technical Reports Server (NTRS)

Boyle, R. F.; Ross, R. G., Jr.; Krebs, Carolyn A. (Technical Monitor)

2001-01-01

Mechanical cryocoolers represent a significant enabling technology for NASA's Earth and Space Science Enterprises, as well as augmenting existing capabilities in space exploration. An over-view is presented of on-going efforts at the Goddard Space Flight Center and the Jet Propulsion Laboratory in support of current flight projects, near-term flight instruments, and long-term technology development.

77 FR 75243 - Self-Regulatory Organizations; Options Clearing Corporation; Order Approving Proposed Rule Change...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-19

... modeling and risk management procedures (``Risk Management Proposal'') \\9\\ is approved by the Commission.... The enhancements are part of OCC's ongoing efforts to test and improve its risk management operations... Index Options,\\12\\ and only subject to the filing and approval of the Risk Management Proposal, as...

78 FR 27479 - Notice of Request for Approval To Continue To Collect New Information: Confidential Close Call...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-10

... project. This data collection effort is in support of a five-year research study aiming at improving rail... ongoing research study is conducted by the Office of Human Factors in the Federal Railroad Administration... DEPARTMENT OF TRANSPORTATION Research and Innovative Technology Administration [Docket Number RITA...

Using Public Posting as a Motivation Strategy in Physical Education, Sport, and Adult Exercise Settings

ERIC Educational Resources Information Center

Martin, Matt; Sharpe, Tom

2009-01-01

One of the ongoing challenges that physical educators, coaches, and fitness professionals face is discovering and implementing motivational strategies that encourage long-term participation and effort. This challenge exists in public school physical education classes, on the playing field, and in structured adult physical activity settings. In…

Office of the Under Secretary of Defense (Comptroller)

Science.gov Websites

provide all of the information you need to understand the budget and financial management policy of the functionalStatements OUSD(C) History FMR Budget Materials Budget Execution Financial Management Improving Financial will also find information about the Department's ongoing effort to improve efficiency and

Observer Training Manual for the Changing Teacher Practice Study. Revised Manual.

ERIC Educational Resources Information Center

Barnes, Susan

This observer training manual was developed as a central component of a research effort, Changing Teacher Practice (CTP), which was designed to increase the frequency of effective teaching behaviors and staff development strategies in an ongoing school system. The observations focused on two major aspects of classroom teaching--instruction and…

Resource Requirements and Costs of Developing and Delivering MOOCs

ERIC Educational Resources Information Center

Hollands, Fiona M.; Tirthali, Devayani

2014-01-01

Given the ongoing alarm regarding uncontrollable costs of higher education, it would be reasonable to expect not only concern about the impact of MOOCs on educational outcomes, but also systematic efforts to document the resources expended on their development and delivery. However, there is little publicly available information on MOOC costs that…

Pilot Guidelines for Improving Instructional Materials Through the Process of Learner Verification and Revision.

ERIC Educational Resources Information Center

Educational Products Information Exchange Inst., Stony Brook, NY.

Learner Verification and Revision (LVR) Process of Instructional Materials is an ongoing effort for the improvement of instructional materials based on systematic feedback from learners who have used the materials. This evaluation gives publishers a method of identifying instructional strengths and weaknesses of a product and provides an…

78 FR 10167 - Pollinator Summit: Status of Ongoing Collaborative Efforts To Protect Pollinators; Notice of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-13

... in activities to reduce potential acute exposure of honey bees and pollinators to pesticides. Invited... exposure of honey bees and pollinators to pesticides. This action is directed to the public in general, and... crops. While there are several factors affecting honey bee health, pesticides are among these variables...

Integrating species distributional, conservation planning, and individual based population models: A case study in critical habitat evaluation for the Northern Spotted Owl

EPA Science Inventory

Background / Question / Methods As part of the ongoing northern spotted owl recovery planning effort, we evaluated a series of alternative potential critical habitat scenarios using a species-distribution model (MaxEnt), a conservation-planning model (Zonation), and an individua...

Towards a Caring Community: Modeling, Dialogue, Practice, and Confirmation.

ERIC Educational Resources Information Center

Harris, Charlotte Matthews

A teacher educator, engaged in ongoing practitioner inquiry to explore self as well as program, examines her evolution as a teacher of teachers through reflection, systematic inquiry, and collaboration. Relating autobiographically, she conjures up her professional stories and listens to her voice in an effort to define and refine her role, reflect…

Analysis of Shadowing Effects on Spacecraft Power Systems

NASA Technical Reports Server (NTRS)

1995-01-01

As part of an ongoing effort within the NASA Lewis Research Center's Power Systems Project Office to assist in the design and characterization of future space-based power systems, analyses have been performed to assess the effects of shadowing on the capabilities of various power systems on the International Space Station and the Russian MIR.

Forum on Emerging Infectious Diseases Highlights Leading-Edge Research | Poster

Cancer.gov

Scientists and professionals from multiple governmental agencies recently gathered at NCI at Frederick for a forum on newly emerging infectious diseases, threats to public health, and ongoing efforts to study high-risk pathogens. During the one-day event, which was sponsored by the National Interagency Confederation for Biological Research’s Scientific Interaction

High School/College Partnerships. 1981 Current Issues in Higher Education, No 1.

ERIC Educational Resources Information Center

American Association for Higher Education, Washington, DC.

The need for better high school/college articulation is addressed in five papers. In "High School/College Partnerships That Work," Ernest L. Boyer describes the ongoing efforts to encourage high school/college collaboration and considers five principles necessary for establishing cooperative programs, including the need for educators at…

A Progress Report on an Exploratory Mathematics Course: Incorporating a Programming Component

ERIC Educational Resources Information Center

Goldberg, Robert; Waxman, Jerry

2004-01-01

This paper reports on an ongoing effort to incorporate a programming component into exploratory mathematics courses and analyzes some of the many practical considerations required for successfully managing such a course in large lecture hall classes. Two pedagogical paradigms (top-down and bottom-up) are compared and contrasted for teaching Visual…

The NMC Horizon Report: 2011 K-12 Edition

ERIC Educational Resources Information Center

Johnson, L.; Adams, S.; Haywood, K.

2011-01-01

"The NMC Horizon Report" series is the most visible outcome of the New Media Consortium. (NMC) Horizon Project, an ongoing research effort established in 2002 that identifies and describes emerging technologies likely to have a large impact on teaching, learning, research, or creative expression within education around the globe. This volume, "The…

Conceptions of Evidence Use in School Districts: Mapping the Terrain

ERIC Educational Resources Information Center

Coburn, Cynthia E.; Talbert, Joan E.

2006-01-01

Current policies place unprecedented demands on districts to use evidence to guide their educational improvement efforts. How districts respond is likely to be influenced by how individuals in the district conceptualize what it means to use evidence in their ongoing work. This study draws on sensemaking and institutional theory to investigate how…

Facing Fears: The Feasibility of Anxiety Universal Prevention Efforts with Children and Adolescents

ERIC Educational Resources Information Center

Miller, Lynn D.

2008-01-01

A few comprehensive reviews of the effectiveness of prevention programs of mental disorders in school-age children ((Greenberg et al., 2003) and (Weisz et al., 2005)) conclude that while several well-designed studies demonstrate the potential of preventive intervention, greater attention and ongoing rigorous research is critical. The benefits and…

Building Lectures and Building Bridges with Socio-Economically Disadvantaged Students

ERIC Educational Resources Information Center

Phillips, Peter; Loch, Birgit

2011-01-01

This paper is an empirical analysis of the first stage of an ongoing effort to introduce technology to enhance student learning in introductory corporate finance within a multi-campus and multi-mode regional Australian University. The engagement and performance of low socio-economic status (SES) students is of particular interest because…

Opening Teachers' Minds to Philosophy: The Crucial Role of Teacher Education

ERIC Educational Resources Information Center

Knight, Sue; Collins, Carol

2014-01-01

Why has the "Philosophy for Children" movement failed to make significant educational inroads in Australia, given the commitment and ongoing efforts of philosophers and educators alike who have worked hard in recent decades to bring philosophy to our schools? In this article we single out one factor as having particular importance,…

77 FR 3781 - Pediatric Medical Devices; Public Workshop; Reopening of Comment Period

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-25

... discussion of how to determine when it is appropriate to use, and how to use, existing scientific research... use of scientific research data to support pediatric medical device efficacy claims. This is part of an on-going effort to address the ways scientific research data can be used to support pediatric...

Creative Tension: Turn The Challenges of Learning Together Into Opportunities

ERIC Educational Resources Information Center

Dobbs, Christina L.; Ippolito, Jacy; Charner-Laird, Megin

2016-01-01

Effective and authentic communities of practice in schools have the potential to support teachers in improving their instructional practices around perennial challenges, such as improving the literacy skills of all students. But before they can achieve such goals, communities of practice take time to build, effort to sustain, and ongoing support…

Progress in the improved lattice calculation of direct CP-violation in the Standard Model

NASA Astrophysics Data System (ADS)

Kelly, Christopher

2018-03-01

We discuss the ongoing effort by the RBC & UKQCD collaborations to improve our lattice calculation of the measure of Standard Model direct CP violation, ɛ', with physical kinematics. We present our progress in decreasing the (dominant) statistical error and discuss other related activities aimed at reducing the systematic errors.

Information as Power. An Anthology of Selected United States Army War College Student Papers. Volume 4

DTIC Science & Technology

2010-01-01

Coombs , Crisis Management and Communication ...and coordinating all U.S. PSYOP efforts in Afghanistan. 14. Coombs , Crisis Management and Communication . 15. Coombs , Ongoing Crisis ...commonly associated with, and seen as a requirement in, crisis response communications . A crisis is “a significant threat to operations

Toward The Identification Of Candidate Genes Involved In Black Pod Disease Resistance In Theobroma cacao L.

USDA-ARS?s Scientific Manuscript database

Black Pod (Phytophthora sp.) has a devastating effect on the worldwide cacao (Theobroma cacao) yield and incorporating resistance into production fields has been an ongoing effort of breeding programs. Previous meta-QTL analysis of genetic maps created with a variety of molecular markers identified...

Toward the identification of candidate genes involved In black pod disease resistance in Theobroma cacao L.

USDA-ARS?s Scientific Manuscript database

Black Pod (Phytophthora sp.) has a devastating effect on the worldwide cacao (Theobroma cacao) yield and incorporating resistance into production fields has been an ongoing effort of breeding programs. Previous meta-QTL analysis of genetic maps created with a variety of molecular markers identified...

WORKSHOP ON MERCURY IN PRODUCTS, PROCESSES, WASTE AND THE ENVIRONMENT: ELIMINATING, REDUCING AND MANAGING RISKS FROM NON-COMBUSTION SOURCES (PROGRAM FLYER)

EPA Science Inventory

The Workshop is designed to achieve three goals:
1. Convey public and private sector perspectives on the management of mercury in products, processes, and wastes;
2. Present ongoing efforts that address mercury prevention, elimination, noncombustion treatment and disposal; ...

76 FR 57050 - Approaches to Reducing Sodium Consumption; Establishment of Dockets; Request for Comments, Data...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-15

... stroke. FDA and FSIS recognize ongoing efforts by a number of members of the restaurant and packaged food... manufacturing of foods and preparation of restaurant foods, reduction in sodium consumption in the United States... Act of 2010, certain restaurants and similar retail food establishments must provide, upon request...

Academic Program Review--Concerns and Justification.

ERIC Educational Resources Information Center

Heldman, D. R.

Academic program review should not be considered a new phenomenon in higher education; reviews of various types have been conducted on a continuing basis. The renewed importance of an organized effort has been stimulated by the inability of funding sources to maintain levels of support required to insure quality in all on-going programs. Current…

Balancing Good Intentions: Protecting the Privacy of Electronic Health Information

ERIC Educational Resources Information Center

McClanahan, Kitty

2008-01-01

Electronic information is a vital but complex component in the modern health care system, fueling ongoing efforts to develop a universal electronic health record infrastructure. This innovation creates a substantial tension between two desirable values: the increased quality and utility of patient medical records and the protection of the privacy…

Probing High School Physics Students' Views and Concerns about Learning Activities

ERIC Educational Resources Information Center

Langley, Dorothy; Eylon, Bat-Sheva

2006-01-01

The current study is framed within an ongoing effort of probing students' attitudes and expectations about knowing and learning physics, which has driven several investigations during the past decade. The questionnaire we developed focuses on physics students' views regarding a variety of specific learning activities, which are presented by title…

Stirling engines for automobiles

NASA Technical Reports Server (NTRS)

Beremand, D. G.

1979-01-01

The results of recent and ongoing automobile Stirling engine development efforts are reviewed and technology status and requirements are identified. Key technology needs include those for low cost, high temperature (1300 - 1500 F) metal alloys for heater heads, and reliable long-life, low-leakage shaft seals. Various fuel economy projections for Stirling powered automobiles are reviewed and assessed.

78 FR 46362 - Information Collection Sent to the Office of Management and Budget (OMB) for Approval; National...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-31

..., nongovernmental organizations; and academic institutions to advance the development of The National Map and other national geospatial databases. This effort will support our need to supplement ongoing data collection.... Description of Respondents: State, local, and tribal governments; private and non-profit firms; and academic...

The Program Evaluator's Role in Cross-Project Pollination.

ERIC Educational Resources Information Center

Yasgur, Bruce J.

An expanded duties role of the multiple-program evaluator as an integral part of the ongoing decision-making process in all projects served is defended. Assumptions discussed included that need for projects with related objectives to pool resources and avoid duplication of effort and the evaluator's unique ability to provide an objective…

Field Turbidity Methods for the Determination of Lead in Acid Extracts of Dried Paint

EPA Science Inventory

Lead, which can be found in old paint, soil, and dust, has been clearly shown to have adverse health effects on the neurological systems of both children and adults. As part of an ongoing effort to reduce childhood lead poisoning, the U.S. Environmental Protection Agency promulga...

Epidemiology of Phytophthora ramorum in Oregon

Treesearch

E.M. Hansen; A. Kanaskie; E.M. Goheen; N. Osterbauer; W. Sutton

2006-01-01

We are studying how P. ramorum survives and spreads in Oregon tanoak forests. The Oregon outbreak is similar to the epidemic in redwood-tanoak forests of California, with several important differences, however. The disease is confined to scattered stands within a 12 m2 area, and it is subject to an ongoing eradication effort....

Language Revitalization Processes and Prospects: Quichua in the Ecuadorian Andes.

ERIC Educational Resources Information Center

King, Kendall A.

This paper examines efforts to reverse language shift in two indigenous communities in southern Ecuador. The ongoing decline and rapid pace of extinction of many of the world's languages have received increasing amounts of attention, but while processes of language loss and extinction have been extensively studied, relatively little work of…

The NMC Horizon Report: 2014 K-12 Edition

ERIC Educational Resources Information Center

Johnson, L.; Adams Becker, S.; Estrada, V.; Freeman, A.

2014-01-01

"The NMC Horizon Report" series is the most visible outcome of the New Media Consortium (NMC) Horizon Project, an ongoing research effort established in 2002 that identifies and describes emerging technologies likely to have a large impact on teaching, learning, research, or creative expression within every sector of education in some 65…

Virtual Environments and the Ongoing Work of Becoming a Singapore Teacher

ERIC Educational Resources Information Center

Zuiker, Steven J.; Ang, Doreen

2011-01-01

The study explores the intersection between cyberinfrastructure and models of teacher education and professional development in Singapore. A case study explores how a pre-service and an in-service workshop in a virtual environment support efforts to understand and enlist constructivist pedagogies for classroom learning and to foster continuous…

77 FR 5661 - Equal Access to Housing in HUD Programs Regardless of Sexual Orientation or Gender Identity

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-03

... from targeted violence. Passage of the law resulted from the ongoing efforts of individuals personally impacted by hate crime violence, together with nearly 300 civil rights and religious organizations... the proposal continues to promote negative stereotypes and violence against LGBT persons. A commenter...

ASAS-SN Discovery of a Bright Be Star Undergoing a Possible Outburst

NASA Astrophysics Data System (ADS)

Jayasinghe, T.; Stanek, K. Z.; Kochanek, C. S.; Thorstensen, J.; Rupert, J.; Prieto, J. L.; Shields, J. V.; Thompson, T. A.; Holoien, T. W.-S.; Shappee, B. J.; Dong, Subo

2017-09-01

As part of an ongoing effort by ASAS-SN project (Shappee et al. 2014; Kochanek et al. 2017) to characterize and catalog all bright variable stars (e.g., Jayasinghe et al. 2017, ATel #10634, #10677), we report the discovery of a bright Be star undergoing a possible outburst.

Effectiveness of conservation reserve program buffers in the Chesapeake Bay Watershed: 2017 annual report

USDA-ARS?s Scientific Manuscript database

Riparian buffers play an important role in watershed strategies to clean up the Chesapeake Bay, with over 20,000 riparian buffers implemented in the Chesapeake Bay watershed under USDA’S Conservation Reserve Enhancement Program (CREP). This annual report documents an on-going, multi-agency effort to...

Building Scientific Confidence in the Development and Evaluation of Read-Across Using Tox21 Approaches (SOT Annual Meeting)

EPA Science Inventory

Acceptance of read-across is an ongoing challenge and several efforts are underway to identify and address major uncertainties associated with read-across. Several approaches have been proposed but to date few case studies if any have evaluated how Tox21 approaches may be instruc...

78 FR 6321 - PacifiCorp, et al; Notice of FERC Staff Attendance

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-30

...Corp, et al; Notice of FERC Staff Attendance PacifiCorp Docket No. ER13-64-000 Deseret Generation... Regulatory Commission (Commission) hereby gives notice that on January 30, 2013, members of its staff will... and Commission staff's attendance is part of the Commission's ongoing outreach efforts. The meeting...

Going to University: Pacific Island Migrant Perspectives

ERIC Educational Resources Information Center

Cuthill, Michael; Scull, Sue

2011-01-01

Despite extensive and on-going efforts, people from a low socio-economic background continue to be significantly under-represented in Australian higher education. In response to this situation, a two year action research project explored the broad issue of higher education access for young people from low socio-economic backgrounds in South East…

Assessing Greenhouse Gas Emissions from University Purchases

ERIC Educational Resources Information Center

Thurston, Matthew; Eckelman, Matthew J.

2011-01-01

Purpose: A greenhouse gas (GHG) inventory was conducted for Yale University's procurement of goods and services over a one-year period. The goal of the inventory was to identify the financial expenditures resulting in the greatest "indirect" GHG emissions. This project is part of an ongoing effort to quantify and reduce the university's…

The "Synergies" Research-Practice Partnership Project: A "2020 Vision" Case Study

ERIC Educational Resources Information Center

Falk, John H.; Dierking, Lynn D.; Staus, Nancy L.; Wyld, Jennifer N.; Bailey, Deborah L.; Penuel, William R.

2016-01-01

This paper, describes "Synergies," an on-going longitudinal study and design effort, being conducted in a diverse, under-resourced community in Portland, Oregon, with the goal of measurably improving STEM learning, interest and participation by early adolescents, both in school and out of school. Authors examine how the work of this…

Implementing Restorative Justice Practice in Schools: What Pedagogy Reveals

ERIC Educational Resources Information Center

Vaandering, Dorothy

2014-01-01

In the ongoing pursuit for creating safe, nurturing and relational school cultures, educators continue to turn to restorative justice (rj) principles and practice. Predominantly, schools begin to engage with rj in an effort to address harm done, causing its discourse to be situated in literature tied to classroom management and behaviour. However,…

Literacy Teacher Preparation: Ten Truths Teacher Educators Need to Know

ERIC Educational Resources Information Center

Davis Lenski, Susan, Ed.; Grisham, Dana L., Ed.; Wold, Linda S., Ed.

2005-01-01

The quality of teacher preparation is frequently under public scrutiny. In this collection, experts in literacy teacher preparation offer ten truths--based on evidence, not ideology-- that support the ongoing positive efforts of teacher educators. In this book, the reader will find: A review of the existing knowledge base; Evidence of the improved…

A Combined Research/Educational Curriculum in Smart Sensors and Integrated Devices.

ERIC Educational Resources Information Center

Auner, G. W.; Siy, P.; Naik, R.; Wenger, L.; Liu, G-Y.; Schwiebert, L. J.

The researchers are developing a new curriculum which integrates ongoing research efforts in the Center for Smart Sensors and Integrated Devices into a cooperative educational and traineeship program. A forerunner to this program was initiated with funding by a National Science Foundation (NSF) Combined Research and Curriculum Development (CRCD)…

Legal liability for Agent Orange-related illnesses: a reassessment of the 2005 VAVA case and prospects for new litigation.

PubMed

Klickermann, Felix

2016-01-01

Attempts through the US courts to hold the corporations responsible for the production of dioxin-contaminated herbicides used by the US military in the 1960s and early 1970s liable for their ongoing health consequences have failed. This article scrutinizes the most recent judgement - that of the United States District Court for the Eastern District of New York handed down in 2005 following a lawsuit brought by the Vietnam Association of Victims of Agent Orange/dioxin (VAVA). It is argued that despite this judgement there is the potential to bring a further legal case, with some prospect of success, on the basis of: (i) debatable legal judgements in the 2005 decision; (ii) new scientific evidence on the health effects of exposure to Agent Orange; and (iii) cases brought in other jurisdictions. The article concludes by noting the underfunding of ongoing remediation efforts, especially for the provision of assistance to affected individuals, and argues that it is desirable to oblige the producers of the herbicides to contribute financially to these efforts.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thayer, K.J.

The past year has seen several of the Physics Division`s new research projects reach major milestones with first successful experiments and results: the atomic physics station in the Basic Energy Sciences Research Center at the Argonne Advanced Photon Source was used in first high-energy, high-brilliance x-ray studies in atomic and molecular physics; the Short Orbit Spectrometer in Hall C at the Thomas Jefferson National Accelerator (TJNAF) Facility that the Argonne medium energy nuclear physics group was responsible for, was used extensively in the first round of experiments at TJNAF; at ATLAS, several new beams of radioactive isotopes were developed andmore » used in studies of nuclear physics and nuclear astrophysics; the new ECR ion source at ATLAS was completed and first commissioning tests indicate excellent performance characteristics; Quantum Monte Carlo calculations of mass-8 nuclei were performed for the first time with realistic nucleon-nucleon interactions using state-of-the-art computers, including Argonne`s massively parallel IBM SP. At the same time other future projects are well under way: preparations for the move of Gammasphere to ATLAS in September 1997 have progressed as planned. These new efforts are imbedded in, or flowing from, the vibrant ongoing research program described in some detail in this report: nuclear structure and reactions with heavy ions; measurements of reactions of astrophysical interest; studies of nucleon and sub-nucleon structures using leptonic probes at intermediate and high energies; atomic and molecular structure with high-energy x-rays. The experimental efforts are being complemented with efforts in theory, from QCD to nucleon-meson systems to structure and reactions of nuclei. Finally, the operation of ATLAS as a national users facility has achieved a new milestone, with 5,800 hours beam on target for experiments during the past fiscal year.« less

Advanced Curation Activities at NASA: Preparing to Receive, Process, and Distribute Samples Returned from Future Missions

NASA Technical Reports Server (NTRS)

McCubbin, Francis M.; Zeigler, Ryan A.

2017-01-01

The Astromaterials Acquisition and Curation Office (henceforth referred to herein as NASA Curation Office) at NASA Johnson Space Center (JSC) is responsible for curating all of NASA's extraterrestrial samples. Under the governing document, NASA Policy Directive (NPD) 7100.10F JSC is charged with curation of all extraterrestrial material under NASA control, including future NASA missions. The Directive goes on to define Curation as including documentation, preservation, preparation, and distribution of samples for research, education, and public outreach. Here we briefly describe NASA's astromaterials collections and our ongoing efforts related to enhancing the utility of our current collections as well as our efforts to prepare for future sample return missions. We collectively refer to these efforts as advanced curation.

Inhibition of Ras for cancer treatment: the search continues

PubMed Central

Baines, Antonio T.; Xu, Dapeng; Der, Channing J.

2012-01-01

Background The RAS oncogenes (HRAS, NRAS and KRAS) comprise the most frequently mutated class of oncogenes in human cancers (33%), stimulating intensive effort in developing anti-Ras inhibitors for cancer treatment. Discussion Despite intensive effort, to date no effective anti-Ras strategies have successfully made it to the clinic. We present an overview of past and ongoing strategies to inhibit oncogenic Ras in cancer. Conclusions Since approaches to directly target mutant Ras have not been successful, most efforts have focused on indirect approaches to block Ras membrane association or downstream effector signaling. While inhibitors of effector signaling are currently under clinical evaluation, genome-wide unbiased genetic screens have identified novel directions for future anti-Ras drug discovery. PMID:22004085

Advanced Curation Activities at NASA: Implications for Astrobiological Studies of Future Sample Collections

NASA Technical Reports Server (NTRS)

McCubbin, F. M.; Evans, C. A.; Fries, M. D.; Harrington, A. D.; Regberg, A. B.; Snead, C. J.; Zeigler, R. A.

2017-01-01

The Astromaterials Acquisition and Curation Office (henceforth referred to herein as NASA Curation Office) at NASA Johnson Space Center (JSC) is responsible for curating all of NASA's extraterrestrial samples. Under the governing document, NASA Policy Directive (NPD) 7100.10F JSC is charged with curation of all extraterrestrial material under NASA control, including future NASA missions. The Directive goes on to define Curation as including documentation, preservation, preparation, and distribution of samples for re-search, education, and public outreach. Here we briefly describe NASA's astromaterials collections and our ongoing efforts related to enhancing the utility of our current collections as well as our efforts to prepare for future sample return missions. We collectively refer to these efforts as advanced curation.

Protein crystallization studies

NASA Technical Reports Server (NTRS)

Lyne, James Evans

1996-01-01

The Structural Biology laboratory at NASA Marshall Spaceflight Center uses x-ray crystallographic techniques to conduct research into the three-dimensional structure of a wide variety of proteins. A major effort in the laboratory involves an ongoing study of human serum albumin (the principal protein in human plasma) and its interaction with various endogenous substances and pharmaceutical agents. Another focus is on antigenic and functional proteins from several pathogenic organisms including the human immunodeficiency virus (HIV) and the widespread parasitic genus, Schistosoma. My efforts this summer have been twofold: first, to identify clinically significant drug interactions involving albumin binding displacement and to initiate studies of the three-dimensional structure of albumin complexed with these agents, and secondly, to establish collaborative efforts to extend the lab's work on human pathogens.

Information campaign and advocacy efforts to promote access to emergency contraception in Mexico.

PubMed

Ellertson, Charlotte; Heimburger, Angela; Acevedo-Garcia, Dolores; Schiavon, Raffaela; Mejia, Guillermina; Corona, Georgina; del Castillo, Eduardo; Langer, Ana

2002-11-01

Emergency contraception (EC) has the potential to reduce unwanted pregnancy significantly, in Mexico as elsewhere. Recent years have seen tremendous growth in programs and research devoted to expanding access to emergency methods worldwide. In Mexico we developed a comprehensive model introduction effort that included four components: provider training, public information (through a dedicated hotline and website, free media, paid radio and TV spots, participation in talk shows, and alternative media channels), collaboration with the public sector to include EC in the official family planning norms, and assistance to partner with commercial firms to register a dedicated EC product. Ongoing efforts to combat misperceptions and overcome opposition are crucial to informing the public and ensuring greater access to the method.

Vibrational spectra and fragmentation pathways of size-selected, D2-tagged ammonium/methylammonium bisulfate clusters.

PubMed

Johnson, Christopher J; Johnson, Mark A

2013-12-19

Particles consisting of ammonia and sulfuric acid are widely regarded as seeds for atmospheric aerosol nucleation, and incorporation of alkylamines has been suggested to substantially accelerate their growth. Despite significant efforts, little direct experimental evidence exists for the structures and chemical processes underlying multicomponent particle nucleation. Here we are concerned with the positively charged clusters of ammonia and sulfuric acid with compositions H(+)(NH3)m(H2SO4)n (2 ≤ m ≤ 5, 1 ≤ n ≤ 4), for which equilibrium geometry structures have been reported in recent computational searches. The computed harmonic vibrational spectra of such minimum energy structures can be directly compared with the experimental spectra of each cluster composition isolated in the laboratory using cryogenic ion chemistry methods. We present one-photon (i.e., linear) infrared action spectra of the isolated gas phase ions cryogenically cooled to 10 K, allowing us to resolve the characteristic vibrational signatures of these clusters. Because the available calculated spectra for different structural candidates have been obtained using different levels of theory, we reoptimized the previously reported structures with several common electronic structure methods and find excellent agreement can be achieved for the (m = 3, n = 2) cluster using CAM-B3LYP with only minor structural differences from the previously identified geometries. At the larger sizes, the experimental spectra strongly resemble that observed for 180 nm ammonium bisulfate particles. The characteristic ammonium- and bisulfate-localized bands are clearly evident at all sizes studied, indicating that the cluster structures are indeed ionic in nature. With the likely (3,2) structure in hand, we then explore the spectral and structural changes caused when methylamine is substituted for ammonia. This process is found to occur with minimal perturbation of the unsubstituted cluster. The thermal decomposition pathways were also evaluated using multiple-photon induced dissociation and are, in all cases, dominated (>100:1) by evaporation of a neutral ammonia molecule rather than methylamine. Spectra obtained for the product cluster ions resulting from this evaporation are consistent with the formation of a single hydrogen bond between two neighboring bisulfate ions, partially regenerating a sulfuric acid molecule. These results provide critical experimental benchmarks for ongoing theoretical efforts to understand the early stages of aerosol growth.

High throughput platforms for structural genomics of integral membrane proteins.

PubMed

Mancia, Filippo; Love, James

2011-08-01

Structural genomics approaches on integral membrane proteins have been postulated for over a decade, yet specific efforts are lagging years behind their soluble counterparts. Indeed, high throughput methodologies for production and characterization of prokaryotic integral membrane proteins are only now emerging, while large-scale efforts for eukaryotic ones are still in their infancy. Presented here is a review of recent literature on actively ongoing structural genomics of membrane protein initiatives, with a focus on those aimed at implementing interesting techniques aimed at increasing our rate of success for this class of macromolecules. Copyright © 2011 Elsevier Ltd. All rights reserved.

GreenIT Service Level Agreements

NASA Astrophysics Data System (ADS)

von Laszewski, Gregor; Wang, Lizhe

In this paper we are introducing a framework towards the inclusion of Green IT metrics as part of service level agreements for future Grids and Clouds. As part of this effort we need to revisit Green IT metrics and proxies that we consider optimizing against in order to develop GreenIT as a Services (GaaS) that can be reused as part of a Software as a Service (SaaS) and Infrastructure Infrastructureas a service (IaaS) framework. We report on some of our ongoing efforts and demonstrate how we already achieve impact on the environment with our services.

Clinical Investigation Program Report Control Symbol MED 300.

DTIC Science & Technology

1983-10-01

13 Agent Induced Delay of Gastric Emptying. (0) (PR) (P) 1979 The Experimental Fat Embolism Syndrome: An Electron 15 Microscopic Study of Lung in...1981 Investigation of Chronic Phantom Pain. (0) (PR) (P) 25 v Year Page Initiated 1981 Experimental Fat Embolism Syndrome: Basic Studies and 26...14 Detail Summary Sheet Date 3 Oct 83 Prot No.: 79-21 Status: Ongoing Title: The Experimental Fat Embolism Syndrome: An Electron Microscopic Study of

Use of Internal Consistency Coefficients for Estimating Reliability of Experimental Tasks Scores

PubMed Central

Green, Samuel B.; Yang, Yanyun; Alt, Mary; Brinkley, Shara; Gray, Shelley; Hogan, Tiffany; Cowan, Nelson

2017-01-01

Reliabilities of scores for experimental tasks are likely to differ from one study to another to the extent that the task stimuli change, the number of trials varies, the type of individuals taking the task changes, the administration conditions are altered, or the focal task variable differs. Given reliabilities vary as a function of the design of these tasks and the characteristics of the individuals taking them, making inferences about the reliability of scores in an ongoing study based on reliability estimates from prior studies is precarious. Thus, it would be advantageous to estimate reliability based on data from the ongoing study. We argue that internal consistency estimates of reliability are underutilized for experimental task data and in many applications could provide this information using a single administration of a task. We discuss different methods for computing internal consistency estimates with a generalized coefficient alpha and the conditions under which these estimates are accurate. We illustrate use of these coefficients using data for three different tasks. PMID:26546100

Associated with aerospace vehicles development of methodologies for the estimation of thermal properties

NASA Technical Reports Server (NTRS)

Scott, Elaine P.

1994-01-01

Thermal stress analyses are an important aspect in the development of aerospace vehicles at NASA-LaRC. These analyses require knowledge of the temperature distributions within the vehicle structures which consequently necessitates the need for accurate thermal property data. The overall goal of this ongoing research effort is to develop methodologies for the estimation of the thermal property data needed to describe the temperature responses of these complex structures. The research strategy undertaken utilizes a building block approach. The idea here is to first focus on the development of property estimation methodologies for relatively simple conditions, such as isotropic materials at constant temperatures, and then systematically modify the technique for the analysis of more and more complex systems, such as anisotropic multi-component systems. The estimation methodology utilized is a statistically based method which incorporates experimental data and a mathematical model of the system. Several aspects of this overall research effort were investigated during the time of the ASEE summer program. One important aspect involved the calibration of the estimation procedure for the estimation of the thermal properties through the thickness of a standard material. Transient experiments were conducted using a Pyrex standard at various temperatures, and then the thermal properties (thermal conductivity and volumetric heat capacity) were estimated at each temperature. Confidence regions for the estimated values were also determined. These results were then compared to documented values. Another set of experimental tests were conducted on carbon composite samples at different temperatures. Again, the thermal properties were estimated for each temperature, and the results were compared with values obtained using another technique. In both sets of experiments, a 10-15 percent off-set between the estimated values and the previously determined values was found. Another effort was related to the development of the experimental techniques. Initial experiments required a resistance heater placed between two samples. The design was modified such that the heater was placed on the surface of only one sample, as would be necessary in the analysis of built up structures. Experiments using the modified technique were conducted on the composite sample used previously at different temperatures. The results were within 5 percent of those found using two samples. Finally, an initial heat transfer analysis, including conduction, convection and radiation components, was completed on a titanium sandwich structural sample. Experiments utilizing this sample are currently being designed and will be used to first estimate the material's effective thermal conductivity and later to determine the properties associated with each individual heat transfer component.

Writing Activities Embedded in Bioscience Laboratory Courses to Change Students' Attitudes and Enhance Their Scientific Writing

ERIC Educational Resources Information Center

Lee, Susan E.; Woods, Kyra J.; Tonissen, Kathryn F.

2011-01-01

We introduced writing activities into a project style third year undergraduate biomolecular science laboratory to assist the students to produce a final report in the form of a journal article. To encourage writing while the experimental work was proceeding, the embedded writing activities required ongoing analysis of experimental data. After…

Wildland fire probabilities estimated from weather model-deduced monthly mean fire danger indices

Treesearch

Haiganoush K. Preisler; Shyh-Chin Chen; Francis Fujioka; John W. Benoit; Anthony L. Westerling

2008-01-01

The National Fire Danger Rating System indices deduced from a regional simulation weather model were used to estimate probabilities and numbers of large fire events on monthly and 1-degree grid scales. The weather model simulations and forecasts are ongoing experimental products from the Experimental Climate Prediction Center at the Scripps Institution of Oceanography...

Opening Possibilities in Experimental Science and Its History: Critical Explorations with Pendulums and Singing Tubes

ERIC Educational Resources Information Center

Cavicchi, Elizabeth

2008-01-01

A teacher and a college student explore experimental science and its history by reading historical texts, and responding with replications and experiments of their own. A curriculum of ever-widening possibilities evolves in their ongoing interactions with each other, history, and such materials as pendulums, flame, and resonant singing tubes.…

Productivity improvement in engineering at Rocketdyne

NASA Technical Reports Server (NTRS)

Nordlund, R. M.; Vogt, S. T.; Woo, A. K.

1985-01-01

The Rocketdyne Division of Rockwell International has embarked on a productivity improvement program in engineering. This effort included participation in the White Collar Productivity Improvement (WCPI) project sponsored by the American Productivity Center. A number of things have been learned through this project. It seems that any productivity improvement project should be employee driven. The Rocketdyne project was essentially started as a result of a grassroots effort to remove some particular hindrances, and employee enthusiasm was a prime factor in the continuing progress of the effort. A significant result was that awareness of problems at all levels increased. Many issues surfaced in the diagnostic phase, and were then noted and discussed. This process added legitimacy to issues that had previously been merely unspoken concerns. The initial feelings of many members of the pilot group was that significant changes would occur relatively quickly. It is now recognized that this will have to be an ongoing, long-term effort.

Studies on Stress-Strain Relationships of Polymeric Materials Used in Space Applications

NASA Technical Reports Server (NTRS)

Jana, Sadhan C.; Freed, Alan

2002-01-01

A two-year research plan was undertaken in association with Polymers Branch, NASA Glenn Research Center, to carry out experimental and modeling work relating stress and strain behavior of polymeric materials, especially elastomers and vulcanized rubber. An experimental system based on MTS (Mechanical Testing and Simulation) A/T-4 test facility environment has been developed for a broader range of polymeric materials in addition to a design of laser compatible temperature control chamber for online measurements of various strains. Necessary material processing has been accomplished including rubber compounding and thermoplastic elastomer processing via injection molding. A broad suite of testing methodologies has been identified to reveal the complex non-linear mechanical behaviors of rubbery materials when subjected to complex modes of deformation. This suite of tests required the conceptualization, design and development of new specimen geometries, test fixtures, and test systems including development of a new laser based technique to measure large multi-axial deformations. Test data has been generated for some of these new fixtures and has revealed some complex coupling effects generated during multi-axial deformations. In addition, fundamental research has been conducted concerning the foundation principles of rubber thermodynamics and resulting theories of rubber elasticity. Studies have been completed on morphological properties of several thermoplastic elastomers. Finally, a series of steps have been identified to further advance the goals of NASA's ongoing effort.

Emerging Childhoods and Immanent Becomings: Considering Difference in One Child's Encounters with Popular Culture

ERIC Educational Resources Information Center

Sherbine, Kortney

2016-01-01

Ongoing debates over children's encounters with popular culture are grounded in representational images of what childhood is and what childhood should be. As such, the tendency to overcode and regulate children's behaviors, relationships, and desires are often part of a greater effort to prepare the child to fit fixed and essentialized notions of…

Using Citizen Scientists to Measure the Effects of Ozone Damage on Native Wildflowers

ERIC Educational Resources Information Center

Bricker, Patricia Lynn; Sachs, Susan; Binkley, Russell

2010-01-01

Since 2004, middle and high school students have been monitoring the effects of ground-level ozone by collecting data on observable leaf injury on cutleaf coneflower ("Rudbeckia laciniata") and crownbeard ("Verbesina occidentalis") in the Great Smoky Mountains National Park. This project is part of an ongoing citizen-science effort in which…

Standards for the Global Information Infrastructure (GII): A Review of Recent Developments, Ongoing Efforts, Future Directions and Issues.

ERIC Educational Resources Information Center

Needleman, Mark H.

1996-01-01

Reviews developments related to standards in electronic and networked information. Discusses traditional library and Internet communities, and notes the importance of having a supporting infrastructure in place. Topics include: Z39.50; Z39.56 Serial Item/Contribution Identifier (SICI); Interlibrary Loan (ILL) Protocol; character set standards;…

How Much Is Learning Measurement Worth? Assessment Costs in Low-Income Countries

ERIC Educational Resources Information Center

Wagner, Daniel A.; Babson, Andrew; Murphy, Katie M.

2011-01-01

Timely and credible data on student learning has become a global issue in the ongoing effort to improve educational outcomes. With the potential to serve as a powerful diagnostic tool to gauge the overall health and well-being of an educational system, educational assessments have received increasing attention among specialists and the media.…

Maintenance of Effort: An Evolving Federal-State Policy Approach to Ensuring College Affordability

ERIC Educational Resources Information Center

Alexander, F. King; Harnisch, Thomas; Hurley, Daniel; Moran, Robert

2010-01-01

Congress has recently focused on the complex relationship between federal student aid, states' funding appropriations for higher education, and institutional tuition and fee levels. Fueling this focus is the ongoing cost shit in public higher education, from states to students and families, as well as to the federal government via student aid…

NASA Planetary Astronomy Lunar Atmospheric Imaging Study

NASA Technical Reports Server (NTRS)

Stern, S. Alan

1996-01-01

Authors have conducted a program of research focused on studies of the lunar atmosphere. Also present preliminary results of an ongoing effort to determine the degree that metal abundances in the lunar atmosphere are stoichiometric, that is, reflective of the lunar surface composition. We make the first-ever mid-ultraviolet spectroscopic search for emission from the lunar atmosphere.

Identifying Best Practice in a Shifting Landscape: Making Sense of RTI in the Context of SLD Identification

ERIC Educational Resources Information Center

Lindstrom, Jennifer H.; Sayeski, Kristin

2013-01-01

The Individuals with Disabilities Education Act (2004) has had substantial influence on special education in general and the field of learning disabilities in particular. Since its reauthorization in 2004, ongoing regulatory efforts have been underway to determine its operationalization and implementation. Of particular concern to those involved…

77 FR 77090 - Notice of Public Meeting, Las Cruces District Resource Advisory Council Meeting, New Mexico

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-31

... use a telecommunications device for the deaf (TDD) may call the Federal Information Relay Service... RAC advises the Secretary of the Interior, through the BLM, on a variety of planning and management... from the BLM Las Cruces District Manager, updates on ongoing issues and planning efforts, and Restore...

78 FR 20354 - Notice of Public Meeting, Las Cruces District Resource Advisory Council Meeting, New Mexico

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-04

... Street, Las Cruces, NM, 88005, 575-525-4338. Persons who use a telecommunications device for the deaf... the BLM, on a variety of planning and management issues associated with public land management in New... ongoing issues and planning efforts, presentation on the TriCounty Resource Management Plan/ Environmental...

78 FR 44590 - Notice of Public Meeting, Las Cruces District Resource Advisory Council Meeting, New Mexico

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-24

... Street, Las Cruces, NM, 88005, 575-525-4338. Persons who use a telecommunications device for the deaf... the BLM, on a variety of planning and management issues associated with public land management in New... Manager, updates on ongoing issues and planning efforts, presentation on the TriCounty Resource Management...

Vibroacoustic Response of Pad Structures to Space Shuttle Launch Acoustic Loads

NASA Technical Reports Server (NTRS)

Margasahayam, R. N.; Caimi, Raoul E.

1995-01-01

This paper presents a deterministic theory for the random vibration problem for predicting the response of structures in the low-frequency range (0 to 20 hertz) of launch transients. Also presented are some innovative ways to characterize noise and highlights of ongoing test-analysis correlation efforts titled the Verification Test Article (VETA) project.

(En)visioning Success: The Anatomy and Functions of Vision in the Basic Course.

ERIC Educational Resources Information Center

Williams, Glen

The success of the basic course in speech communication depends largely on a vision that values the course and its place in the undergraduate curriculum; emphasizes the necessity of ongoing training and development of teaching assistants and instructors; and values scholarship that will enhance those efforts as well as improve dedication. Vision…

Genetic variation in the US Peanut Mini-core collection for agronomy, seed chemistry and nutrient quality traits in peanut

USDA-ARS?s Scientific Manuscript database

The ongoing genome sequencing effort in peanut will result in numerous molecular markers that can be applied to the diverse collection of recently purified mini-core germplasm. This will provide an opportunity to mine valuable genes for peanut cultivar improvement. Association mapping based on linka...

Examining the Relationship between 2D Diagrammatic Conventions and Students' Success on Representational Translation Tasks in Organic Chemistry

ERIC Educational Resources Information Center

Olimpo, Jeffrey T.; Kumi, Bryna C.; Wroblewski, Richard; Dixon, Bonnie L.

2015-01-01

Two-dimensional (2D) diagrams are essential in chemistry for conveying and communicating key knowledge about disciplinary phenomena. While experts are adept at identifying, interpreting, and manipulating these representations, novices often are not. Ongoing research efforts in the field suggest that students' effective use of concrete and virtual…

Remote Sensing for Tropical Forest Assessment

Treesearch

AJR Gillespie

1994-01-01

The purpose of this workshop was to allow remote sensing experts from Latin America, the U.S.A., and FAO to discuss state-of-the-art methodology in remote sensing of forest environments, and to develop plans on how to better incorporate this technology into FAO and national forest inventory efforts. The workshop included numerous presentations of ongoing activities, as...

The Impact of Structured Writing and Developing Awareness of Learning Preferences on the Performance and Attitudes of Engineering Teams

ERIC Educational Resources Information Center

Dahm, Kevin; Newell, James; Newell, Heidi; Harvey, Roberta

2009-01-01

This paper discusses efforts to develop metacognition in teams of engineering students by: first, exploring personal learning patterns, and second, ongoing biweekly journaling exercises. Thirty-three junior and senior engineering students (30 chemical engineer, one each from mechanical, civil and electrical) working on semester-long projects in…

Citizenship Education Policy at the School District Level. Issue Paper

ERIC Educational Resources Information Center

Miller, Jeffery J.

2004-01-01

At a time when the ongoing effort to reform public education in the United States is strongly influenced by requirements of the federal No Child Left Behind Act (NCLB), policymakers and education leaders at all levels are focused on improving student achievement in math and reading. Emphasis on these two areas, however, is generating concern among…

Three New Z Cam Stars (Abstract)

NASA Astrophysics Data System (ADS)

Simonsen, M.

2016-12-01

(Abstract only) I will present the evidence and discovery stories of three cataclysmic variables who appear to be members of the Z Cam class of dwarf novae. One discovered by a lone visual observer and his unwavering patience and persistence, one through the directed effort of the ongoing Z CamPaign and one via survey data from the Gaia satellite.

SILVAH-OAK: ensuring adoption by engaging users in the full cycle of forest research

Treesearch

Susan L. Stout; Pat Brose; Kurt Gottschalk; Gary Miller; Pete Knopp; Gary Rutherford; Mark Deibler; Gary Frank; Gary Gilmore

2007-01-01

Recent Forest Service Research and Development (FS R&D) logic modeling efforts focused on program delivery stated that an important precondition for effective science delivery was the engagement of users and partners throughout the full research and development cycle. The ongoing partnership among the Pennsylvania Department of Conservation and Natural Resources...

Enhanced detection of infectious prions by direct ELISA from the brains of asymptomatic animals using DRM2-118 monoclonal antibody and Gdn-HCl

USDA-ARS?s Scientific Manuscript database

In this report we describe improved methods for the detection of infectious prions by immunoassay for the diagnosis of transmissible spongiform encephalopathies (TSEs) from asymptomatic animals. Tissue samples obtained as part of ongoing TSE surveillance efforts are often unsuitable for histopathol...

NREL Research Proves Wind Can Provide Ancillary Grid Fault Response | News

Science.gov Websites

controllable grid interface (CGI) test facility, which simulates the real-time conditions of a utility-scale power grid. This began an ongoing, Energy Department-funded research effort to test how wind turbines test their equipment under any possible grid fault condition. Researchers such as Mark McDade, project

77 FR 27448 - Amended Notice of Intent To Revise the Scope of an Environmental Impact Statement for the...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-10

... availability of the infrastructure needed to support the transfer, handling, examination, and packaging of... nuclear fuel is transferred into dry storage containers and placed into temporary storage at NRF, prior to... Container System for Management of Naval Spent Nuclear Fuel (DOE/EIS-0251). Ongoing efforts to sustain the...

DefenseLink Special: Operation Enduring Freedom Marks 4 Years

Science.gov Websites

DefenseLink.mil Aug. 04, 2015 War on Terror Transformation News Products Press Resources Images Websites Contact Afghanistan and ushering in Operation Enduring Freedom and the global war on terror. That volley, launched Oct action represented just one front in an ongoing U.S. effort against terror networks. "Today, we

Laboratory Instrumentation: An Exploration of the Impact of Instrumentation on Student Learning

ERIC Educational Resources Information Center

Warner, Don L.; Brown, Eric C.; Shadle, Susan E.

2016-01-01

Academic programs generally work to make their laboratory curriculum both as instrumentation rich and up to date as possible. However, little is known about the relationship between the use of instrumentation in the curriculum and student learning. As part of our department's ongoing assessment efforts, a project was designed to probe this…

Hierarchical population structure in greater sage-grouse provides insight into management boundary delineation

Treesearch

Todd B. Cross; David E. Naugle; John C. Carlson; Michael K. Schwartz

2016-01-01

Understanding population structure is important for guiding ongoing conservation and restoration efforts. The greater sage-grouse (Centrocercus urophasianus) is a species of concern distributed across 1.2 million km2 of western North America. We genotyped 1499 greater sagegrouse from 297 leks across Montana, North Dakota and South Dakota using a 15 locus...

An Evaluation of the Chicago Public Schools' Efforts To Relieve Student Overcrowding at Elementary Schools. Progress Report.

ERIC Educational Resources Information Center

Valdez, Virginia

To address the inadequate condition of school buildings across the city, the Chicago Public Schools (CPS) established a Capital Improvement Program (CIP) in 1996, an ongoing plan for reviewing and upgrading CPS infrastructure over 5 years. Capital projects include additions, annexes, new replacement schools, and new area schools. This report…