Science.gov

Sample records for op wereldwijde graanmarkten

  1. Co-op

    SciTech Connect

    Nathan Barton, LLNL; Richard Becker, LLNL; Robert Chen, LLNL; Richard Hornung, LLNL; Jaroslaw Knap, LLNL; Gary Kumfert, LLNL; James Leek, LLNL; John May, LLNL; Miller, Patrick; Morrone, Chris; Tannahill, John

    2007-05-25

    Co-op is primarily middleware software, a runtime system for the support of the Cooperative Parallel Programming model. This model is based on using whole SPMD applications as components in a scalable programming, and having them treat one another as single objects and communicate via remote method invocation. Also included is some application level software: (1) a metric space database library for managing data items located in an arbitrary metric space and retrieving based on nearest neighbor queries; and (2) a Krieging extrapolation library for use in implementing adaptive sampling for generic multiscale simulations.

  2. OPS83: Style Guide for High Performance.

    DTIC Science & Technology

    1987-06-01

    er and ,de,,l U by Sc Mor,o’ - FIEL GRUP SB-GOUP Artificial intelligence, rule-based systems, OPS83, Rete algorithm, program optimization 19 ABTAC Coot...OPS83....................................................... I Rete Match Algorithm ....................................................... Function ...implementation of the Rete algorithm reported here. RETE MATCH ALGORITHM Function /Overview The function of the Rete match algorithm is to compute the

  3. Candidate OP Phyla: Importance, Ecology and Cultivation Prospects.

    PubMed

    Rohini Kumar, M; Saravanan, V S

    2010-10-01

    OP phyla were created in the domain bacteria, based on the group of 16S rRNA gene sequences recovered from the Obsidian Pool. However, due to the lack of cultured representative it is referred to as candidate phyla. Wider ecological occurrence was predicted for the OP phyla, especially OP3, OP10 and OP11. Recently, members of phylum OP5 and OP10 were cultured, providing clues to their cultivation prospects. At last the bioprospecting potentials of the OP members are discussed herein.

  4. No developmental failure of cultured tooth germs from osteopetrotic (op/op) mice.

    PubMed

    Ida-Yonemochi, Hiroko; Saku, Takashi

    2002-07-01

    Incisor tooth germs of osteopetrotic (op/op) mice are known to fail to erupt, but form odontomas in their root apices instead, due to invasion of alveolar bone trabeculae into the tooth germs. The purpose of this study is to determine if the tooth developmental failures in op/op mice are intrinsic or secondarily arise as a result of the defective bone metabolism due to lack of macrophage colony-stimulating factor (M-CSF). We isolated mandibular first molar tooth germs from normal and op/op mice and cultured them under conditions with or without bone tissues which had been formed around tooth germs. Tooth germs from normal mice, cultured for a week, showed almost the same developmental features as those of mice with the corresponding age. They were surrounded with dental follicular tissues and were never invaded by bone trabeculae. On the other hand, op/op tooth germs cultured in the presence of bone components were invaded by alveolar bone trabeculae around tooth germs in the same manner as shown in vivo. When cultured without bone, they developed without any interruptions. These findings indicated that op/op tooth germs had potential for normal development and that their abnormal development was a secondary phenomenon caused by lack of bone remodeling in the early phase of odontogenesis.

  5. 45 CFR 156.515 - CO-OP standards.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false CO-OP standards. 156.515 Section 156.515 Public... Operated and Oriented Plan Program § 156.515 CO-OP standards. (a) General. A CO-OP must satisfy the...) Governance requirements. A CO-OP must meet the following governance requirements: (1) Member control. A...

  6. 45 CFR 156.515 - CO-OP standards.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false CO-OP standards. 156.515 Section 156.515 Public... Operated and Oriented Plan Program § 156.515 CO-OP standards. (a) General. A CO-OP must satisfy the...) Governance requirements. A CO-OP must meet the following governance requirements: (1) Member control. A...

  7. 45 CFR 156.515 - CO-OP standards.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false CO-OP standards. 156.515 Section 156.515 Public... Operated and Oriented Plan Program § 156.515 CO-OP standards. (a) General. A CO-OP must satisfy the...) Governance requirements. A CO-OP must meet the following governance requirements: (1) Member control. A...

  8. The CO-OP Guide

    SciTech Connect

    Michael, J.; /Fermilab

    1991-08-16

    You are at D0, the newest and most advanced experiment at Fermilab. Its goal is to find the 'top quark', nicknamed 'truth'. theoretically one of the six fundamental building blocks of matter. Combinations of the six quarks are said to make up electrons, protons and neutrons. Your group at D0 is the cryogenic division. Its goal is to provide and maintain a cryogenic system which ultimately supplies and controls the liquid argon used in the giant cryostats for the experiment. The high purity liquid argon is needed to keep the detector modules inside the cryostats cold, so that they will operate properly. Your job at D0 is to be a co-op for the research and development group of the cryogenics division. Your goals are dependent on the needs of the cryo group. D0 is where you will spend most of your time. The co-op office is located on what is known as the 3rd floor, but is actually on the ground floor. The floor directly above the 3rd floor is the 5th floor, which contains your immediate superiors and the D0 secretary. The 6th and top floor is above that, and contains the D0 secretary for official and important business. On the other side of the D0 assembly building is the cryo control room. This is where the cryogenic piping system is remotely monitored and controlled. Other important sites at D0 include the trailer city on the north parking lot, which has the D0 secretary who handles all the payroll matters (among other duties), and the portakamp in the south parking lot. Besides D0, which is named for its location on the particle accelerator ring. the most important place is Wilson Hall. That is the large building shaped like a big Atact symbol. It contains various important people such as the safety group. the personnel department (which you have already encountered. being hired), the minor stock room, the cafeteria, the Fermi library. Ramsey Auditorium. etc. Behind Wilson Hall is the Booster Ring, which accelerates particles before they are injected into the main

  9. OpTIIX Mission Overview and Education/Public Outreach

    NASA Astrophysics Data System (ADS)

    Krueger, T.; Swade, D.

    2013-10-01

    The Optical Testbed and Integration on ISS Experiment (OpTIIX) is a technology demonstration to design, develop, deliver, robotically assemble, and successfully operate an observatory on the International Space Station (ISS). An OpTIIX Education and Public Outreach (EPO) program is being designed to bring OpTIIX and its discoveries to amateur observers, students, educators, and the public. In addition OpTIIX will be available to the professional community for additional tests using the assembled OpTIIX configuration.

  10. Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.

    PubMed

    Wiktor-Jedrzejczak, W; Bartocci, A; Ferrante, A W; Ahmed-Ansari, A; Sell, K W; Pollard, J W; Stanley, E R

    1990-06-01

    Osteopetrotic (op/op) mutant mice suffer from congenital osteopetrosis due to a severe deficiency of osteoclasts. Furthermore, the total number of mononuclear phagocytes is extremely low in affected mice. Serum, 11 tissues, and different cell and organ conditioned media from op/op mice were shown to be devoid of biologically active colony-stimulating factor 1 (CSF-1), whereas all of these preparations from littermate control +/+ and +/op mice contained the growth factor. The deficiency was specific for CSF-1 in that serum or conditioned media from op/op mice possessed elevated levels of at least three other macrophage growth factors. Partial correction of the op/op defect was observed following intraperitoneal implantation of diffusion chambers containing L929 cells, which in culture produce CSF-1 as their sole macrophage growth factor. No rearrangement of the CSF-1 gene in op/op mice was detected by Southern analysis. However, in contrast to control lung fibroblasts, which contained 4.6- and 2.3-kilobase CSF-1 mRNAs, only the 4.6-kilobase species was detected in op/op cells. An alteration in the CSF-1 gene is strongly implicated as the primary defect in op/op mice because they do not contain detectable CSF-1, their defect is correctable by administration of CSF-1, the op locus and the CSF-1 gene map within the same region of mouse chromosome 3, their CSF-1 mRNA biosynthesis is altered, and the op/op phenotype is consistent with the phenotype expected in a CSF-1 deficient mouse.

  11. O&P (Ova and Parasite) Test

    MedlinePlus

    ... diagnose an infection of the digestive system (gastrointestinal, GI tract). Since there are many causes of GI infections, an O&P may be used in conjunction with other tests, such as a gastrointestinal (GI) pathogens panel or a stool culture , to help ...

  12. OP-32 Automated Data System. Functional Description,

    DTIC Science & Technology

    1983-09-06

    which may. be used as inu o the-OP-32 system include:nt at • L, iData element descriptions are in Appendix c, FORDLMS User’s Guide, Vol 1s aun 1980.Phed...Fund AMO Automation Management Office AYSAL Average Yearly Salary BDFA Basic Daily Food Allowance BEAMS Budget Execution and Appropriation Management

  13. Why Should Your Company Co-op?

    ERIC Educational Resources Information Center

    Rollins, Wayne

    1991-01-01

    Discusses how companies can benefit from cooperative education (lower labor and recruitment costs; improved employee retention and work performance), types of jobs appropriate for co-op (assistant; project work; trainee); types of structures available, and how to establish a cooperative education program. (JOW)

  14. How to Form a Food Co-op.

    ERIC Educational Resources Information Center

    Dodge, Philip; And Others

    Based on questions asked during an adult education course at Truman College (Chicago), this booklet was designed to be a simple organizing manual for small neighborhood preorder food cooperatives (co-ops). The guide covers basic information for organizing a co-op, definition of a co-op, what jobs are needed, getting the food, wholesale sources,…

  15. OpSite Plus in the management of exuding wounds.

    PubMed

    Fear, M

    2001-08-01

    This article discusses the use of OpSite Plus (formerly known as OpSite Post-Op ) in the community setting. This semi permeable film dressing with an absorbent pad was evaluated by the community hospital and by practice and district nurses within Plymouth's NHS Primary Care Trust.

  16. How to Form a Food Co-op.

    ERIC Educational Resources Information Center

    Dodge, Philip; And Others

    Based on questions asked during an adult education course at Truman College (Chicago), this booklet was designed to be a simple organizing manual for small neighborhood preorder food cooperatives (co-ops). The guide covers basic information for organizing a co-op, definition of a co-op, what jobs are needed, getting the food, wholesale sources,…

  17. Joint SatOPS Compatibility Efforts

    NASA Technical Reports Server (NTRS)

    Smith, Danford

    2010-01-01

    This slide presentation reviews NASA Goddard Space Flight Center's (GSFC) participation in the interagency cooperation committee, the Joint SatOps Compatibility Committee (JSCC), and the compatible Sat 2 efforts. Part of GSFC's participation in the JSCC is to work with the Goddard Mission Systems Evolution Center (GMSEC) to provides a publish/subscribe framework to enable rapid integration of commercially available satellite control products.

  18. Macrophage deficiency in osteopetrotic (op/op) mice inhibits activation of satellite cells and prevents hypertrophy in single soleus fibers.

    PubMed

    Ohira, T; Wang, X D; Ito, T; Kawano, F; Goto, K; Izawa, T; Ohno, H; Kizaki, T; Ohira, Y

    2015-05-15

    Effects of macrophage on the responses of soleus fiber size to hind limb unloading and reloading were studied in osteopetrotic homozygous (op/op) mice with inactivated mutation of macrophage colony-stimulating factor (M-CSF) gene and in wild-type (+/+) and heterozygous (+/op) mice. The basal levels of mitotically active and quiescent satellite cell (-46 and -39% vs. +/+, and -40 and -30% vs. +/op) and myonuclear number (-29% vs. +/+ and -28% vs. +/op) in fibers of op/op mice were significantly less than controls. Fiber length and sarcomere number in op/op were also less than +/+ (-22%) and +/op (-21%) mice. Similar trend was noted in fiber cross-sectional area (CSA, -15% vs. +/+, P = 0.06, and -14% vs. +/op, P = 0.07). The sizes of myonuclear domain, cytoplasmic volume per myonucleus, were identical in all types of mice. The CSA, length, and the whole number of sarcomeres, myonuclei, and mitotically active and quiescent satellite cells, as well as myonuclear domain, in single muscle fibers were decreased after 10 days of unloading in all types of mice, although all of these parameters in +/+ and +/op mice were increased toward the control values after 10 days of reloading. However, none of these levels in op/op mice were recovered. Data suggest that M-CSF and/or macrophages are important to activate satellite cells, which cause increase of myonuclear number during fiber hypertrophy. However, it is unclear why their responses to general growth and reloading after unloading are different.

  19. Tempel 1 First Op-Nav

    NASA Technical Reports Server (NTRS)

    2005-01-01

    [figure removed for brevity, see original site] Tempel 1 First Optical Navigation

    On Monday, April 25, the Deep Impact spacecraft obtained its first optical navigation (Op-Nav) image of comet Tempel 1. At the time the picture was taken the distance between spacecraft and comet was 64 million kilometers (39.7 million miles) away. The exposure -- known as a 'negative image' -- is used by the spacecraft team to assist in navigation and instrument calibration. The spacecraft will start imaging the comet on a regular basis in about 10 days.

  20. CSF-1 deficiency in the op/op mouse has differential effects on macrophage populations and differentiation stages.

    PubMed

    Wiktor-Jedrzejczak, W; Ratajczak, M Z; Ptasznik, A; Sell, K W; Ahmed-Ansari, A; Ostertag, W

    1992-09-01

    Osteopetrosis and the absence of colony-stimulating factor 1 (CSF-1) in op/op mice are associated with decreased cellularity of the bone marrow (to one tenth of the normal), a very significant reduction in the number of cells recovered from peritoneal, pleural, and alveolar lavages, moderate leukopenia, and a slight decrease in the number of cells per spleen and thymus. Furthermore, op/op mice possess deficiencies in the number of macrophages in various organs. These cells are apparently absent in the bone marrow, severely reduced (5%-15% of the normal number) in peritoneal and pleural cavities and in the lungs. In addition, a marked decrease in the frequency and total number of circulating monocytes is present (5% of the normal). The deficiency of macrophages is less severe in the liver, spleen, and thymus of op/op mice (approximately 30% of those seen in normal). There is a concomitant redistribution of macrophage progenitor cells (granulocyte-macrophage colony-forming units, CFU-GM) in op/op mice from the marrow to the spleen and liver, associated with an increased sensitivity to interleukin 3 (IL-3). Their total number is decreased at least threefold compared to control mice. Moreover, op/op mice have at least a fivefold reduction in the total number of day-11 spleen colony-forming units (CFU-S) associated with their redistribution to the spleen and liver. These data suggest that the macrophage system in op/op mice is reduced at all levels tested, that is, at the level of mature macrophages, the level of progenitors, and the level of stem cells, whereas the redistribution of progenitor and stem cells could be viewed as a secondary consequence of osteopetrosis. Furthermore, these data suggest that macrophage dependency in vivo on CSF-1 is limited and different in various organs. Particularly in the liver, spleen, and thymus, other growth factors may significantly compensate for CSF-1 deficiency. Based on the relative decrease in the number of CFU-GM in the op/op

  1. Tera-Ops Processing for ATR

    NASA Technical Reports Server (NTRS)

    Udomkesmalee, Suraphol; Padgett, Curtis; Zhu, David; Lung, Gerald; Howard, Ayanna

    2000-01-01

    A three-dimensional microelectronic device (3DANN-R) capable of performing general image convolution at the speed of 1012 operations/second (ops) in a volume of less than 1.5 cubic centimeter has been successfully built under the BMDO/JPL VIGILANTE program. 3DANN-R was developed in partnership with Irvine Sensors Corp., Costa Mesa, California. 3DANN-R is a sugar-cube-sized, low power image convolution engine that in its core computation circuitry is capable of performing 64 image convolutions with large (64x64) windows at video frame rates. This paper explores potential applications of 3DANN-R such as target recognition, SAR and hyperspectral data processing, and general machine vision using real data and discuss technical challenges for providing deployable systems for BMDO surveillance and interceptor programs.

  2. VEP Responses to Op-Art Stimuli

    PubMed Central

    O’Hare, Louise; Clarke, Alasdair D. F.; Pollux, Petra M. J.

    2015-01-01

    Several types of striped patterns have been reported to cause adverse sensations described as visual discomfort. Previous research using op-art-based stimuli has demonstrated that spurious eye movement signals can cause the experience of illusory motion, or shimmering effects, which might be perceived as uncomfortable. Whilst the shimmering effects are one cause of discomfort, another possible contributor to discomfort is excessive neural responses: As striped patterns do not have the statistical redundancy typical of natural images, they are perhaps unable to be encoded efficiently. If this is the case, then this should be seen in the amplitude of the EEG response. This study found that stimuli that were judged to be most comfortable were also those with the lowest EEG amplitude. This provides some support for the idea that excessive neural responses might also contribute to discomfort judgements in normal populations, in stimuli controlled for perceived contrast. PMID:26422207

  3. 2011 Internship & Co-Op Survey. Research Brief

    ERIC Educational Resources Information Center

    National Association of Colleges and Employers (NJ1), 2011

    2011-01-01

    The National Association of Colleges and Employers' (NACE's) "2011 Internship & Co-op Survey" indicates that internships are an integral and ever-important part of the college recruiting scene. The survey finds that employers expect to increase internship hiring by about 7 percent this year and co-op positions by nearly 9 percent. Furthermore,…

  4. Co-op Essay - Tour 1

    NASA Technical Reports Server (NTRS)

    Porter, Derrick

    2014-01-01

    The Mission Operations Directorate (MOD) is responsible for the training, planning and performance of all U.S. manned operations in space. Within this directorate all responsibilities are divided up into divisions. The EVA, Robotics & Crew Systems Operations Division performs ground operations and trains astronauts to carry out some of the more "high action" procedures in space. For example they orchestrate procedures like EVAs, or ExtraVehicular Activities (spacewalks), and robotics operations external to the International Space Station (ISS). The robotics branch of this division is responsible for the use of the Mobile Servicing System (MSS). This system is a combination of two robotic mechanisms and a series of equipment used to transport them on the ISS. The MSS is used to capture and position visiting vehicles, transport astronauts during EVAs, and perform external maintenance tasks on the ISS. This branch consists of two groups which are responsible for crew training and flight controlling, respectively. My first co-op tour took place Fall 2013. During this time I was given the opportunity to work in the robotics operations branch of the Mission Operations Directorate at NASA's Johnson Space Center. I was given a variety of tasks that encompassed, at a base level, all the aspects of the branch.

  5. OP-ELM: optimally pruned extreme learning machine.

    PubMed

    Miche, Yoan; Sorjamaa, Antti; Bas, Patrick; Simula, Olli; Jutten, Christian; Lendasse, Amaury

    2010-01-01

    In this brief, the optimally pruned extreme learning machine (OP-ELM) methodology is presented. It is based on the original extreme learning machine (ELM) algorithm with additional steps to make it more robust and generic. The whole methodology is presented in detail and then applied to several regression and classification problems. Results for both computational time and accuracy (mean square error) are compared to the original ELM and to three other widely used methodologies: multilayer perceptron (MLP), support vector machine (SVM), and Gaussian process (GP). As the experiments for both regression and classification illustrate, the proposed OP-ELM methodology performs several orders of magnitude faster than the other algorithms used in this brief, except the original ELM. Despite the simplicity and fast performance, the OP-ELM is still able to maintain an accuracy that is comparable to the performance of the SVM. A toolbox for the OP-ELM is publicly available online.

  6. DRACO: Didymos Reconnaissance and Asteroid Camera for Op-Nav

    NASA Astrophysics Data System (ADS)

    Fletcher, Z. J.; Cheng, A. F.; Barnouin, O. S.; Chabot, N. L.; Reed, C. L.

    2016-10-01

    The proposed DART mission is the first demonstration of kinetic impact for deflection of an asteroid. We describe DART's instrument DRACO's (Didymos Reconaissance and Asteroid Camera for Op-nav) requirements, resulting design, and planned operations.

  7. Dorothy Jorgensen - Co-Op Tour Summary

    NASA Technical Reports Server (NTRS)

    Jorgensen, Dorothy

    2014-01-01

    NASA is a household name in this day and age, known commonly as America's government-run powerhouse of innovation and space exploration. It is a common dream for students to be a part of NASA's workforce, but I did not realize that it was my dream until I found that I could not imagine working anywhere else. From August to December, I had the privilege of a co-op tour with NASA at the Johnson Space Center. The National Aeronautics and Space Administration (NASA) first formed in the early hysteria of the Cold War, and in its early days it received enormous funding and political support. It was America's response to the Russian Sputnik, which was a not only a stark symbol of what was suddenly possible, but also of how far behind the United States had fallen in the race for technology. The political atmosphere in the world has since changed, but NASA's drive to push the boundaries of the impossible has not faded: NASA's primary mission has been exploration for the betterment of mankind, and it works towards that mission to this day. The specific NASA site that I worked in was by a coast near Houston, TX, at the Johnson Space Center (Figure 1). I was led on my first day of work to a building dedicated to Structural Engineering (Building 13), which was where I would be spending most of my time in the months to come. It was here that I had my desk and cubicle, and would later do the bulk of my computer modeling and theoretical planning. Later that day we traveled to the Vibrations and Acoustics Test Facility (Building 49), and here I was shown the parts we would use for our technical project and the locations we would work in. I worked in the Loads and Dynamics Branch of the Structural Engineering Division, in the Engineering Directorate.

  8. Long-term time series prediction using OP-ELM.

    PubMed

    Grigorievskiy, Alexander; Miche, Yoan; Ventelä, Anne-Mari; Séverin, Eric; Lendasse, Amaury

    2014-03-01

    In this paper, an Optimally Pruned Extreme Learning Machine (OP-ELM) is applied to the problem of long-term time series prediction. Three known strategies for the long-term time series prediction i.e. Recursive, Direct and DirRec are considered in combination with OP-ELM and compared with a baseline linear least squares model and Least-Squares Support Vector Machines (LS-SVM). Among these three strategies DirRec is the most time consuming and its usage with nonlinear models like LS-SVM, where several hyperparameters need to be adjusted, leads to relatively heavy computations. It is shown that OP-ELM, being also a nonlinear model, allows reasonable computational time for the DirRec strategy. In all our experiments, except one, OP-ELM with DirRec strategy outperforms the linear model with any strategy. In contrast to the proposed algorithm, LS-SVM behaves unstably without variable selection. It is also shown that there is no superior strategy for OP-ELM: any of three can be the best. In addition, the prediction accuracy of an ensemble of OP-ELM is studied and it is shown that averaging predictions of the ensemble can improve the accuracy (Mean Square Error) dramatically. Copyright © 2013 Elsevier Ltd. All rights reserved.

  9. Application of Boiler Op for combustion optimization at PEPCO

    SciTech Connect

    Maines, P.; Williams, S.; Levy, E.

    1997-09-01

    Title IV requires the reduction of NOx at all stations within the PEPCO system. To assist PEPCO plant personnel in achieving low heat rates while meeting NOx targets, Lehigh University`s Energy Research Center and PEPCO developed a new combustion optimization software package called Boiler Op. The Boiler Op code contains an expert system, neural networks and an optimization algorithm. The expert system guides the plant engineer through a series of parametric boiler tests, required for the development of a comprehensive boiler database. The data are then analyzed by the neural networks and optimization algorithm to provide results on the boiler control settings which result in the best possible heat rate at a target NOx level or produce minimum NOx. Boiler Op has been used at both Potomac River and Morgantown Stations to help PEPCO engineers optimize combustion. With the use of Boiler Op, Morgantown Station operates under low NOx restrictions and continues to achieve record heat rate values, similar to pre-retrofit conditions. Potomac River Station achieves the regulatory NOx limit through the use of Boiler Op recommended control settings and without NOx burners. Importantly, any software like Boiler Op cannot be used alone. Its application must be in concert with human intelligence to ensure unit safety, reliability and accurate data collection.

  10. Interactions of OP0595, a Novel Triple-Action Diazabicyclooctane, with β-Lactams against OP0595-Resistant Enterobacteriaceae Mutants.

    PubMed

    Livermore, David M; Warner, Marina; Mushtaq, Shazad; Woodford, Neil

    2015-11-09

    OP0595 is a novel diazabicyclooctane which, like avibactam, inhibits class A and C β-lactamases. In addition, unlike avibactam, it has antibacterial activity, with MICs of 0.5 to 4 μg/ml for most members of the family Enterobacteriaceae, owing to inhibition of PBP2; moreover, it acts synergistically with PBP3-active β-lactams independently of β-lactamase inhibition, via an "enhancer effect." Enterobacteriaceae mutants stably resistant to 16 μg/ml OP0595 were selected on agar at frequencies of approximately 10(-7). Unsurprisingly, OP0595 continued to potentiate substrate β-lactams against mutants derived from Enterobacteriaceae with OP0595-inhibited class A and C β-lactamases. Weaker potentiation of partners, especially aztreonam, cefepime, and piperacillin--less so meropenem--remained frequent for OP0595-resistant Enterobacteriaceae mutants lacking β-lactamases or with OP0595-resistant metallo-β-lactamases (MBLs), indicating that the enhancer effect is substantially retained even when antibiotic activity is lost. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  11. Carbon Dioxide Observational Platform System (CO-OPS), feasibility study

    NASA Technical Reports Server (NTRS)

    Bouquet, D. L.; Hall, D. W.; Mcelveen, R. P.

    1987-01-01

    The Carbon Dioxide Observational Platform System (CO-OPS) is a near-space, geostationary, multi-user, unmanned microwave powered monitoring platform system. This systems engineering feasibility study addressed identified existing requirements such as: carbon dioxide observational data requirements, communications requirements, and eye-in-the-sky requirements of other groups like the Defense Department, the Forestry Service, and the Coast Guard. In addition, potential applications in: earth system science, space system sciences, and test and verification (satellite sensors and data management techniques) were considered. The eleven month effort is summarized. Past work and methods of gathering the required observational data were assessed and rough-order-of magnitude cost estimates have shown the CO-OPS system to be most cost effective (less than $30 million within a 10 year lifetime). It was also concluded that there are no technical, schedule, or obstacles that would prevent achieving the objectives of the total 5-year CO-OPS program.

  12. The MetOp satellite - Weather information from polar orbit

    NASA Astrophysics Data System (ADS)

    Edwards, Peter G.; Berutti, Bruno; Blythe, Paul; Callies, Joerg; Carlier, Stefane; Fransen, Cees; Krutsch, Rainer; Lefebvre, Alain-Robert; Loiselet, Marc; Stricker, Nico

    2006-08-01

    MetOp-A is Europe's first polar-orbiting satellite dedicated to operational meteorology. With its array of advanced instruments, it will provide data of unprecedented accuracy and resolution on temperature and humidity, wind speed and direction over the ocean, and ozone and other trace gases, making a huge contribution to global weather forecasting and climate monitoring. In addition, MetOp-A will observe land and ocean surfaces and its search-and-rescue service will help ships and aircraft in distress.

  13. ProOpDB: Prokaryotic Operon DataBase.

    PubMed

    Taboada, Blanca; Ciria, Ricardo; Martinez-Guerrero, Cristian E; Merino, Enrique

    2012-01-01

    The Prokaryotic Operon DataBase (ProOpDB, http://operons.ibt.unam.mx/OperonPredictor) constitutes one of the most precise and complete repositories of operon predictions now available. Using our novel and highly accurate operon identification algorithm, we have predicted the operon structures of more than 1200 prokaryotic genomes. ProOpDB offers diverse alternatives by which a set of operon predictions can be retrieved including: (i) organism name, (ii) metabolic pathways, as defined by the KEGG database, (iii) gene orthology, as defined by the COG database, (iv) conserved protein domains, as defined by the Pfam database, (v) reference gene and (vi) reference operon, among others. In order to limit the operon output to non-redundant organisms, ProOpDB offers an efficient method to select the most representative organisms based on a precompiled phylogenetic distances matrix. In addition, the ProOpDB operon predictions are used directly as the input data of our Gene Context Tool to visualize their genomic context and retrieve the sequence of their corresponding 5' regulatory regions, as well as the nucleotide or amino acid sequences of their genes.

  14. Crossing Boundaries: Co-Op Students Relearning to Write

    ERIC Educational Resources Information Center

    Brent, Doug

    2012-01-01

    This article reviews the deeply conflicted literature on learning transfer, especially as it applies to rhetorical knowledge and skill. It then describes a study in which six students are followed through their first co-op work term to learn about which resources they draw on as they enter a new environment of professional writing. It suggests…

  15. Engaging the public through writing an op-ed

    NASA Astrophysics Data System (ADS)

    Labosier, Chris; Zhu, Laiyin; Quiring, Steven

    2012-10-01

    In May, prior to the start of the 2012 hurricane season, AGU asked us to write an op-ed for the Houston Chronicle on the importance of funding hurricane research. We were excited to be asked and pleased that AGU facilitated the process by providing us with some guidance on writing the op-ed. Given the impact that Hurricane Ike had in Texas just a few years ago, we felt it was important to remind the citizens of the greater Houston metropolitan area of the societal benefits of funding hurricane research. Thanks to the assistance of AGU staff, writing the article required only a few hours of time. Our op-ed was published in the print edition of the Houston Chronicle on 1 June 2012, the official start of the hurricane season (http://www.chron.com/default/article/Tight-budgets-posing-threat-to-Texas-hurricane-3600363.php). It was picked up by the media relations office in the College of Geosciences at Texas A&M University and featured on the college's Web site in the dean's biweekly briefing and on its Facebook page. As a result, the op-ed reached a large and diverse audience.

  16. A Study of Initial Employment Characteristics between Co-op and Non-co-op Community College Graduates.

    ERIC Educational Resources Information Center

    Owen, J. Robert; Clark, Aaron C.

    2001-01-01

    Comparison of 24 community college engineering graduates who participated in cooperative education and 13 nonco-op graduates found no significant employment differences in terms of organizational socialization, relevance of job-to-career plans, access to resources, or participation in decision making. Findings may be specific to this community…

  17. Using Learning Environments to Create Meaningful Work for Co-Op Students

    ERIC Educational Resources Information Center

    Nevison, Colleen; Drewery, David; Pretti, Judene; Cormier, Lauren

    2017-01-01

    For students in cooperative education (co-op) programs, meaningful work is a critical aspect of participation and a key component of program success. However, studies have not explored how meaningful work can be created for co-op students. The purpose of this study was to evaluate the relationship between co-op students' perceptions of a learning…

  18. 7 CFR 1944.662 - Eligibility of HPG assistance on rental properties or co-ops.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... co-ops. 1944.662 Section 1944.662 Agriculture Regulations of the Department of Agriculture (Continued... Preservation Grants § 1944.662 Eligibility of HPG assistance on rental properties or co-ops. (a) Ownership. The owner(s) of rental properties or co-ops must own the dwelling at the time of receiving assistance...

  19. 7 CFR 1944.662 - Eligibility of HPG assistance on rental properties or co-ops.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... co-ops. 1944.662 Section 1944.662 Agriculture Regulations of the Department of Agriculture (Continued... Preservation Grants § 1944.662 Eligibility of HPG assistance on rental properties or co-ops. (a) Ownership. The owner(s) of rental properties or co-ops must own the dwelling at the time of receiving assistance...

  20. 7 CFR 1944.662 - Eligibility of HPG assistance on rental properties or co-ops.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... co-ops. 1944.662 Section 1944.662 Agriculture Regulations of the Department of Agriculture (Continued... Preservation Grants § 1944.662 Eligibility of HPG assistance on rental properties or co-ops. (a) Ownership. The owner(s) of rental properties or co-ops must own the dwelling at the time of receiving assistance...

  1. 7 CFR 1944.662 - Eligibility of HPG assistance on rental properties or co-ops.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... co-ops. 1944.662 Section 1944.662 Agriculture Regulations of the Department of Agriculture (Continued... Preservation Grants § 1944.662 Eligibility of HPG assistance on rental properties or co-ops. (a) Ownership. The owner(s) of rental properties or co-ops must own the dwelling at the time of receiving assistance...

  2. 7 CFR 1944.662 - Eligibility of HPG assistance on rental properties or co-ops.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... co-ops. 1944.662 Section 1944.662 Agriculture Regulations of the Department of Agriculture (Continued... Preservation Grants § 1944.662 Eligibility of HPG assistance on rental properties or co-ops. (a) Ownership. The owner(s) of rental properties or co-ops must own the dwelling at the time of receiving assistance...

  3. The MetOp second generation 3MI instrument

    NASA Astrophysics Data System (ADS)

    Manolis, Ilias; Grabarnik, Semen; Caron, Jérôme; Bézy, Jean-Loup; Loiselet, Marc; Betto, Maurizio; Barré, Hubert; Mason, Graeme; Meynart, Roland

    2013-10-01

    The MetOp-SG programme is a joint Programme of EUMETSAT and ESA. ESA develops the prototype MetOp-SG satellites (including associated instruments) and procures, on behalf of EUMETSAT, the recurrent satellites (and associated instruments). Two parallel, competitive phase A/B1 studies for MetOp Second Generation (MetOp-SG) have been concluded in May 2013. The implementation phases (B2/C/D/E) are planned to start the first quarter of 2014. ESA is responsible for instrument design of six missions, namely Microwave Sounding Mission (MWS), Scatterometer mission (SCA), Radio Occultation mission (RO), Microwave Imaging mission (MWI), Ice Cloud Imager (ICI) and Multi-viewing, Multi-channel, Multi-polarisation imaging mission (3MI). The paper will present the main performances of the 3MI instrument and will highlight the performance improvements with respect to its heritage derived by the POLDER instrument, such as number of spectral channels and spectral range coverage, swath and ground spatial resolution. The engineering of some key performance requirements (multi-viewing, polarisation sensitivity, straylight etc.) will also be discussed. The results of the feasibility studies will be presented together with the programmatics for the instrument development. Several pre-development activities have been initiated to retire highest risks and to demonstrate the ultimate performances of the 3MI optics. The scope, objectives and current status of those activities will be presented. Key technologies involved in the 3MI instrument design and implementation are considered to be: the optical design featuring aspheric optics, the implementation of broadband Anti Reflection coatings featuring low polarisation and low de-phasing properties, the development and qualification of polarisers with acceptable performances as well as spectral filters with good uniformities over a large clear aperture.

  4. All Conservation Opportunity Areas (ECO.RES.ALL_OP_AREAS)

    EPA Pesticide Factsheets

    The All_OP_Areas GIS layer are all the Conservation Opportunity Areas identified by MoRAP (produced for EPA Region 7). They designate areas with potential for forest, grassland and forest/grassland mosaic conservation. These are areas of natural or semi-natural forest land cover that are at least 75 meters away from roads and away from patch edges. OAs were modeled by creating distance grids using the National Land Cover Database and the Census Bureau's TIGER roads files.

  5. All Conservation Opportunity Areas (ECO.RES.ALL_OP_AREAS)

    EPA Pesticide Factsheets

    The All_OP_Areas GIS layer are all the Conservation Opportunity Areas identified by MoRAP (produced for EPA Region 7). They designate areas with potential for forest, grassland and forest/grassland mosaic conservation. These are areas of natural or semi-natural forest land cover that are at least 75 meters away from roads and away from patch edges. OAs were modeled by creating distance grids using the National Land Cover Database and the Census Bureau's TIGER roads files.

  6. Tailoring a ConOps for NASA LSP Integrated Operations

    NASA Technical Reports Server (NTRS)

    Owens, Skip Clark V., III

    2017-01-01

    An integral part of the Systems Engineering process is the creation of a Concept of Operations (ConOps) for a given system, with the ConOps initially established early in the system design process and evolved as the system definition and design matures. As Integration Engineers in NASA's Launch Services Program (LSP) at Kennedy Space Center (KSC), our job is to manage the interface requirements for all the robotic space missions that come to our Program for a Launch Service. LSP procures and manages a launch service from one of our many commercial Launch Vehicle Contractors (LVCs) and these commercial companies are then responsible for developing the Interface Control Document (ICD), the verification of the requirements in that document, and all the services pertaining to integrating the spacecraft and launching it into orbit. However, one of the systems engineering tools that have not been employed within LSP to date is a Concept of Operations. The goal of this paper is to research the format and content that goes into these various aerospace industry ConOps and tailor the format and content into template form, so the template may be used as an engineering tool for spacecraft integration with future LSP procured launch services. This tailoring effort was performed as the authors final Masters Project in the Spring of 2016 for the Stevens Institute of Technology and modified for publication with INCOSE (Owens, 2016).

  7. The BIR Motifs Mediate Dominant Interference and Oligomerization of Inhibitor of Apoptosis Op-IAP

    PubMed Central

    Hozak, Rebecca R.; Manji, Gulam A.; Friesen, Paul D.

    2000-01-01

    The defining structural motif of the inhibitor of apoptosis (iap) protein family is the BIR (baculovirus iap repeat), a highly conserved zinc coordination domain of ∼70 residues. Although the BIR is required for inhibitor-of-apoptosis (IAP) function, including caspase inhibition, its molecular role in antiapoptotic activity in vivo is unknown. To define the function of the BIRs, we investigated the activity of these structural motifs within Op-IAP, an efficient, virus-derived IAP. We report here that Op-IAP1–216, a loss-of-function truncation which contains two BIRs but lacks the C-terminal RING motif, potently interfered with Op-IAP's capacity to block apoptosis induced by diverse stimuli. In contrast, Op-IAP1–216 had no effect on apoptotic suppression by caspase inhibitor P35. Consistent with a mechanism of dominant inhibition that involves direct interaction between Op-IAP1–216 and full-length Op-IAP, both proteins formed an immunoprecipitable complex in vivo. Op-IAP also self-associated. In contrast, the RING motif-containing truncation Op-IAP183–268 failed to interact with or interfere with Op-IAP function. Substitution of conserved residues within BIR 2 caused loss of dominant inhibition by Op-IAP1–216 and coincided with loss of interaction with Op-IAP. Thus, residues encompassing the BIRs mediate dominant inhibition and oligomerization of Op-IAP. Consistent with dominant interference by interaction with an endogenous cellular IAP, Op-IAP1–216 also lowered the survival threshold of cultured insect cells. Taken together, these data suggest a new model wherein the antiapoptotic function of IAP requires homo-oligomerization, which in turn mediates specific interactions with cellular apoptotic effectors. PMID:10669762

  8. Enzymatic degradation of monocrotophos by extracellular fungal OP hydrolases.

    PubMed

    Jain, Rachna; Garg, Veena

    2013-11-01

    The present study explores the potential of extracellular fungal organophosphate (OP) hydrolase for the degradation of monocrotophos. Extracellular OP hydrolases were isolated and purified from five different fungal isolates viz. Aspergillus niger (M1), Aspergillus flavus (M2), Penicillium aculeatum (M3), Fusarium pallidoroseum (M4), and Macrophomina sp. (M5) by AmSO4 precipitation, dialysis, and G-100 chromatography. M3 showed highest percentage yield of 68.81 followed by 55.41 % for M1. Each of the purified enzyme fraction constituted of two different subunits of 33- and 67-kDa molecular weight. Optimum enzyme fraction (150 μg ml(-1)) rapidly degraded monocrotophos within 120 h in phosphorus-free liquid culture medium (CZM) with K deg of 0.0368, 0.0138, 0.048, 0.016, 0.0138, and 0.048 day(-1) and half-life of 0.79, 2.11, 0.6, 1.8, and 2.11 days for M1, M2, M3, M4, and M5, respectively. The results were further confirmed by high performance thin layer chromatography and Fourier transform infrared which indicate the disappearance of monocrotophos by hydrolytic cleavage of vinyl phosphate bond. The overall order of enzymatic degradation was found to be P. aculeatum > A. niger > F. pallidoroseum > A. flavus = Macrophomina sp. Hence, the study concludes that extracellular OP hydrolases efficiently degraded monocrotophos and could be used as a potential candidate for the detoxification of this neurotoxin pesticide.

  9. Electing a candidate: a speculative history of the bacterial phylum OP10.

    PubMed

    Dunfield, Peter F; Tamas, Ivica; Lee, Kevin C; Morgan, Xochitl C; McDonald, Ian R; Stott, Matthew B

    2012-12-01

    In 1998, a cultivation-independent survey of the microbial community in Obsidian Pool, Yellowstone National Park, detected 12 new phyla within the Domain Bacteria. These were dubbed 'candidate divisions' OP1 to OP12. Since that time the OP10 candidate division has been commonly detected in various environments, usually as part of the rare biosphere, but occasionally as a predominant community component. Based on 16S rRNA gene phylogeny, OP10 comprises at least 12 class-level subdivisions. However, despite this broad ecological and evolutionary diversity, all OP10 bacteria have eluded cultivation until recently. In 2011, two reference species of OP10 were taxonomically validated, removing the phylum from its 'candidate' status. Construction of a highly resolved phylogeny based on 29 universally conserved genes verifies its standing as a unique bacterial phylum. In the following paper we summarize what is known and what is suspected about the newest described bacterial phylum, the Armatimonadetes.

  10. 14O+p elastic scattering in a microscopic cluster model

    SciTech Connect

    Descouvemont, P.; Baye, D.; Leo, F.

    2006-04-26

    The 14O+p elastic scattering is analyzed in a fully microscopic cluster model. With the Resonating Group Method associated with the microscopic R-matrix theory, phase shifts and cross sections are calculated. Data on 16O+p are used to test the precision of the model. For the 14O+p elastic scattering, an excellent agreement is found with recent experimental data. Resonances properties in 15F are discussed.

  11. Is This Op-Amp Any Good?: Lab-Built Checker Removes All Doubt!

    ERIC Educational Resources Information Center

    Harman, Charles

    2007-01-01

    Electronics instructors and students find it very helpful to be able to check an operational amplifier at the proto-board stage. Most students lack the experience or knowledge that it takes to recognize whether an op-amp is operating normally or not. This article discusses a handy op-amp checker that allows one to check and/or test op-amps at the…

  12. Is This Op-Amp Any Good?: Lab-Built Checker Removes All Doubt!

    ERIC Educational Resources Information Center

    Harman, Charles

    2007-01-01

    Electronics instructors and students find it very helpful to be able to check an operational amplifier at the proto-board stage. Most students lack the experience or knowledge that it takes to recognize whether an op-amp is operating normally or not. This article discusses a handy op-amp checker that allows one to check and/or test op-amps at the…

  13. Nuclear localization of the dehydrin OpsDHN1 is determined by histidine-rich motif

    PubMed Central

    Hernández-Sánchez, Itzell E.; Maruri-López, Israel; Ferrando, Alejandro; Carbonell, Juan; Graether, Steffen P.; Jiménez-Bremont, Juan F.

    2015-01-01

    The cactus OpsDHN1 dehydrin belongs to a large family of disordered and highly hydrophilic proteins known as Late Embryogenesis Abundant (LEA) proteins, which accumulate during the late stages of embryogenesis and in response to abiotic stresses. Herein, we present the in vivo OpsDHN1 subcellular localization by N-terminal GFP translational fusion; our results revealed a cytoplasmic and nuclear localization of the GFP::OpsDHN1 protein in Nicotiana benthamiana epidermal cells. In addition, dimer assembly of OpsDHN1 in planta using a Bimolecular Fluorescence Complementation (BiFC) approach was demonstrated. In order to understand the in vivo role of the histidine-rich motif, the OpsDHN1-ΔHis version was produced and assayed for its subcellular localization and dimer capability by GFP fusion and BiFC assays, respectively. We found that deletion of the OpsDHN1 histidine-rich motif restricted its localization to cytoplasm, but did not affect dimer formation. In addition, the deletion of the S-segment in the OpsDHN1 protein affected its nuclear localization. Our data suggest that the deletion of histidine-rich motif and S-segment show similar effects, preventing OpsDHN1 from getting into the nucleus. Based on these results, the histidine-rich motif is proposed as a targeting element for OpsDHN1 nuclear localization. PMID:26442018

  14. Nuclear localization of the dehydrin OpsDHN1 is determined by histidine-rich motif.

    PubMed

    Hernández-Sánchez, Itzell E; Maruri-López, Israel; Ferrando, Alejandro; Carbonell, Juan; Graether, Steffen P; Jiménez-Bremont, Juan F

    2015-01-01

    The cactus OpsDHN1 dehydrin belongs to a large family of disordered and highly hydrophilic proteins known as Late Embryogenesis Abundant (LEA) proteins, which accumulate during the late stages of embryogenesis and in response to abiotic stresses. Herein, we present the in vivo OpsDHN1 subcellular localization by N-terminal GFP translational fusion; our results revealed a cytoplasmic and nuclear localization of the GFP::OpsDHN1 protein in Nicotiana benthamiana epidermal cells. In addition, dimer assembly of OpsDHN1 in planta using a Bimolecular Fluorescence Complementation (BiFC) approach was demonstrated. In order to understand the in vivo role of the histidine-rich motif, the OpsDHN1-ΔHis version was produced and assayed for its subcellular localization and dimer capability by GFP fusion and BiFC assays, respectively. We found that deletion of the OpsDHN1 histidine-rich motif restricted its localization to cytoplasm, but did not affect dimer formation. In addition, the deletion of the S-segment in the OpsDHN1 protein affected its nuclear localization. Our data suggest that the deletion of histidine-rich motif and S-segment show similar effects, preventing OpsDHN1 from getting into the nucleus. Based on these results, the histidine-rich motif is proposed as a targeting element for OpsDHN1 nuclear localization.

  15. Impaired tumor growth in colony-stimulating factor 1 (CSF-1)-deficient, macrophage-deficient op/op mouse: evidence for a role of CSF-1-dependent macrophages in formation of tumor stroma.

    PubMed

    Nowicki, A; Szenajch, J; Ostrowska, G; Wojtowicz, A; Wojtowicz, K; Kruszewski, A A; Maruszynski, M; Aukerman, S L; Wiktor-Jedrzejczak, W

    1996-01-03

    Macrophages have been suggested to play a major role in the immune response to cancer. They have also been suggested to stimulate the formation of tumor stroma and to promote tumor vascularization. The availability of the op/op mouse, which has no endogenous colony-stimulating factor 1 (CSF-1) and which possesses a profound macrophage deficiency, provides a new model to verify these notions. Subcutaneous growth of transplantable Lewis lung cancer (LLC) is markedly impaired in the op/op mice compared with normal littermates. Treatment of tumor-bearing op/op mice with human recombinant CSF-1 corrects this impairment. Histological analysis of tumors grown in op/op and normal mice revealed marked differences. Tumors grown in op/op mice display a decreased mitotic index and pronounced necrosis, particularly hemorrhagic. Moreover, particularly in the op/op tumors, peculiar sinusoid-like abortive vessels (not filled with blood) have been observed. These tumors, in contrast to tumors grown in normal mice, are almost deprived of regular arteries and veins. In contrast to tumors grown in normal mice, they exhibit almost no Sirius red-stained collagenous fibers and Gomori silver-stained reticular fibers. Our data suggest that the CSF-1-dependent macrophage subpopulation missing in op/op mice plays a primary role in supporting tumor stroma formation and tumor vascularization in murine LLC tumors.

  16. Comparative pulsation calculations with OP and OPAL opacities

    NASA Technical Reports Server (NTRS)

    Kanbur, Shashi M.; Simon, Norman R.

    1994-01-01

    Comparative linear nonadiabatic pulsation calculations are presented using the OPAL and Opacity Project opacities. The two sets of opacities include effects due to intermediate coupling and fine structure as well as new abundances. We used two mass luminosity (M-L) relations, one standard (BIT), and one employing substantial convective core overshoot (COV). The two sets of opacities cannot be differentiated on the basis of the stellar pulsation calculations presented here. The BIT relation can model the beat and bump Cepheids with masses between 4 and 7 solar mass, while if the overshoot relation is used, masses between 2 and 6 solar mass are required. In the RR Lyrae regime, we find the inferred masses of globular cluster RRd stars to be little influenced by the choice of OPAL or OP. Finally, the limited modeling we have done is not able to constrain the Cepheid M-L relation based upon period ratios observed in the beat and bump stars.

  17. Comparative pulsation calculations with OP and OPAL opacities

    NASA Technical Reports Server (NTRS)

    Kanbur, Shashi M.; Simon, Norman R.

    1994-01-01

    Comparative linear nonadiabatic pulsation calculations are presented using the OPAL and Opacity Project opacities. The two sets of opacities include effects due to intermediate coupling and fine structure as well as new abundances. We used two mass luminosity (M-L) relations, one standard (BIT), and one employing substantial convective core overshoot (COV). The two sets of opacities cannot be differentiated on the basis of the stellar pulsation calculations presented here. The BIT relation can model the beat and bump Cepheids with masses between 4 and 7 solar mass, while if the overshoot relation is used, masses between 2 and 6 solar mass are required. In the RR Lyrae regime, we find the inferred masses of globular cluster RRd stars to be little influenced by the choice of OPAL or OP. Finally, the limited modeling we have done is not able to constrain the Cepheid M-L relation based upon period ratios observed in the beat and bump stars.

  18. Gaze stability of observers watching Op Art pictures.

    PubMed

    Zanker, Johannes M; Doyle, Melanie; Robin, Walker

    2003-01-01

    It has been the matter of some debate why we can experience vivid dynamic illusions when looking at static pictures composed from simple black and white patterns. The impression of illusory motion is particularly strong when viewing some of the works of 'Op Artists, such as Bridget Riley's painting Fall. Explanations of the illusory motion have ranged from retinal to cortical mechanisms, and an important role has been attributed to eye movements. To assess the possible contribution of eye movements to the illusory-motion percept we studied the strength of the illusion under different viewing conditions, and analysed the gaze stability of observers viewing the Riley painting and control patterns that do not produce the illusion. Whereas the illusion was reduced, but not abolished, when watching the painting through a pinhole, which reduces the effects of accommodation, it was not perceived in flash afterimages, suggesting an important role for eye movements in generating the illusion for this image. Recordings of eye movements revealed an abundance of small involuntary saccades when looking at the Riley pattern, despite the fact that gaze was kept within the dedicated fixation region. The frequency and particular characteristics of these rapid eye movements can vary considerably between different observers, but, although there was a tendency for gaze stability to deteriorate while viewing a Riley painting, there was no significant difference in saccade frequency between the stimulus and control patterns. Theoretical considerations indicate that such small image displacements can generate patterns of motion signals in a motion-detector network, which may serve as a simple and sufficient, but not necessarily exclusive, explanation for the illusion. Why such image displacements lead to perceptual results with a group of Op Art and similar patterns, but remain invisible for other stimuli, is discussed.

  19. Chronic exposure to organophosphate (OP) pesticides and neuropsychological functioning in farm workers: a review.

    PubMed

    Muñoz-Quezada, María Teresa; Lucero, Boris Andrés; Iglesias, Verónica Paz; Muñoz, María Pía; Cornejo, Claudia Alejandra; Achu, Eduardo; Baumert, Brittney; Hanchey, Arianna; Concha, Carlos; Brito, Ana María; Villalobos, Marcos

    2016-01-01

    Previous studies have demonstrated that acute poisoning from exposure to organophosphate (OP) pesticides in agricultural workers causes adverse health effects. However, neuropsychological and cognitive effects of chronic occupational exposure to OP pesticides remain controversial. To identify, evaluate, and systematize existing evidence regarding chronic exposure to OP pesticides and neuropsychological effects in farmworkers. Using the PubMed search engine, a systematic review process was implemented and replicated according to the PRISMA statement. Eligibility criteria included workers over 18 years of age exposed to OP pesticides as well as assessment of neuropsychological and cognitive functioning. Search terms were in English and Spanish languages and included organophosphate and workers. Of the search results, 33 of 1,256 articles meet eligibility criteria. Twenty-four studies found an association between chronic occupational exposure to OP pesticides and low neuropsychological performance in workers. We classified nine of the studies to have study design limitations. Studies indicated occupational exposure to OP pesticides is linked to difficulties in executive functions, psychomotor speed, verbal, memory, attention, processing speed, visual-spatial functioning, and coordination. Nine studies find no relationship between OP pesticides exposure and neuropsychological performance. Overall, evidence suggests an association between chronic occupational exposure to OP pesticides and neuropsychological effects. However, there is no consensus about the specific cognitive skills affected.

  20. 48 CFR 750.7110-3 - Submission of cases to the M/OP Director.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... M/OP Director. 750.7110-3 Section 750.7110-3 Federal Acquisition Regulations System AGENCY FOR... Actions To Protect Foreign Policy Interests of the United States 750.7110-3 Submission of cases to the M/OP Director. Cases to be submitted for consideration by the M/OAA Director shall be prepared...

  1. 48 CFR 750.7110-3 - Submission of cases to the M/OP Director.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... M/OP Director. 750.7110-3 Section 750.7110-3 Federal Acquisition Regulations System AGENCY FOR... Actions To Protect Foreign Policy Interests of the United States 750.7110-3 Submission of cases to the M/OP Director. Cases to be submitted for consideration by the M/OAA Director shall be prepared...

  2. Preparing for High Technology: Successful Co-op Strategies. Research and Development Series No. 263.

    ERIC Educational Resources Information Center

    Franchak, Stephen J.; Smith, O. H. Michael

    This document has been prepared to assist program administrators and practitioners in planning and implementing cooperative (co-op) programs in high technology occupational areas. Information focuses on the key elements, strategies, and procedures of successful co-op programs. The guide contains nine chapters and is based on a review of the…

  3. UTC(OP) based on LNE-SYRTE atomic fountain primary frequency standards

    NASA Astrophysics Data System (ADS)

    Rovera, G. D.; Bize, S.; Chupin, B.; Guéna, J.; Laurent, Ph; Rosenbusch, P.; Uhrich, P.; Abgrall, M.

    2016-06-01

    UTC(OP), the French national realization of the international coordinated universal time, was redesigned and rebuilt. The first step was the implementation in October 2012 of a new algorithm based on a H-maser and on atomic fountain data. Thanks to the new implementation, the stability of UTC(OP) was dramatically improved and UTC(OP) competes with the best time scales available today. Then the hardware generation and distribution of the UTC(OP) physical signals were replaced. Part of the new hardware is composed of commercial devices, but the key elements were specifically developed. One of them is a special switch that allows the UTC(OP) signals to be derived from one of two time scales, based on two different H-masers, which are generated simultaneously. This insures the continuity of the UTC(OP) signal even when a change of the reference H-maser is required. With the new hardware implementation, UTC(OP) is made available through three coherent signals: 100 MHz, 10 MHz and 1 PPS. For more than 3 years, UTC(OP) remained well below 10 ns close to UTC, with a difference even less than 5 ns if we except a short period around MJD 56650.

  4. A Study of the Ethical Orientation of Co-op Students.

    ERIC Educational Resources Information Center

    Tillman, Robert L.

    1990-01-01

    A group of 255 civil engineering students in cooperative education programs responded to 12 hypothetical professional ethics situations in core areas of public interest. Findings showed that (1) co-op influences change from rule-based to act-based ethics; (2) students face ethical dilemmas during co-op; and (3) students considered the consequences…

  5. Chronic exposure to organophosphate (OP) pesticides and neuropsychological functioning in farm workers: a review

    PubMed Central

    Lucero, Boris Andrés; Iglesias, Verónica Paz; Muñoz, María Pía; Cornejo, Claudia Alejandra; Achu, Eduardo; Baumert, Brittney; Hanchey, Arianna; Concha, Carlos; Brito, Ana María; Villalobos, Marcos

    2016-01-01

    Background Previous studies have demonstrated that acute poisoning from exposure to organophosphate (OP) pesticides in agricultural workers causes adverse health effects. However, neuropsychological and cognitive effects of chronic occupational exposure to OP pesticides remain controversial. Objective To identify, evaluate, and systematize existing evidence regarding chronic exposure to OP pesticides and neuropsychological effects in farmworkers. Methods Using the PubMed search engine, a systematic review process was implemented and replicated according to the PRISMA statement. Eligibility criteria included workers over 18 years of age exposed to OP pesticides as well as assessment of neuropsychological and cognitive functioning. Search terms were in English and Spanish languages and included organophosphate and workers. Results Of the search results, 33 of 1,256 articles meet eligibility criteria. Twenty-four studies found an association between chronic occupational exposure to OP pesticides and low neuropsychological performance in workers. We classified nine of the studies to have study design limitations. Studies indicated occupational exposure to OP pesticides is linked to difficulties in executive functions, psychomotor speed, verbal, memory, attention, processing speed, visual–spatial functioning, and coordination. Nine studies find no relationship between OP pesticides exposure and neuropsychological performance. Conclusions Overall, evidence suggests an association between chronic occupational exposure to OP pesticides and neuropsychological effects. However, there is no consensus about the specific cognitive skills affected. PMID:27128815

  6. Aurora B is required for mitotic chromatin-induced phosphorylation of Op18/Stathmin.

    PubMed

    Gadea, Bedrick B; Ruderman, Joan V

    2006-03-21

    Oncoprotein 18/Stathmin (Op18) is a microtubule-destabilizing protein that is inhibited by phosphorylation in response to many types of signals. During mitosis, phosphorylation of Op18 by cdc2 is necessary but not sufficient for Op18 inhibition. The presence of mitotic chromosomes is additionally required and involves phosphorylation of Ser-16 in Xenopus Op18 (and/or Ser-63 in human). Given that Ser-16 is an excellent Aurora A (Aur-A) kinase consensus phosphorylation site and the Aurora kinase inhibitor ZM447439 (ZM) blocks phosphorylation in the activation loop of Aur-A, we asked whether either Aur-A or Aurora B (Aur-B) might regulate Op18. We find that ZM blocks the ability of mitotic chromatin to induce Op18 hyperphosphorylation in Xenopus egg extracts. Depletion of Aur-B, but not Aur-A, blocks hyperphosphorylation of Op18, and chromatin assembled in the absence of Aur-B fails to induce hyperphosphorylation. These results suggest that Aur-B, which concentrates at centromeres of metaphase chromosomes, contributes to localized regulation of Op18 during the process of spindle assembly.

  7. [Do the New German OPS codes map the relevant therapeutic activities in psychiatric clinics?].

    PubMed

    Malevani, Jaroslav; Schillen, Thomas; Speier, Rolf; Zedlick, Dyrk; Kieser, Christian; Klimke, Ansgar

    2011-05-01

    Actual codes for operations and procedures (OPS) in psychiatry and psychosomatics should map cost separating therapeutic activities so far defined in Germany by the normative specifications of the psychiatry staff enactment (PsychPV). OPS codes should also allow re-estimating underlying therapy times. Therapeutic activities of the PsychPV fulfilling the minimal criteria of the OPS definition were classified as multiples of a therapeutic 25 minute unit. Therapeutic activities of the PsychPV are mapped to OPS complex codes in a variable degree (psychiatrists 35 %, psychologists 42 %, nurses 43 %, special therapists 59 %). Actual OPS codes are inappropriate for identifying relevant cost-separating factors in the therapy of psychiatric in-patients. They cannot assure in their actual form the standards given by the PsychPV and need substantial revision. © Georg Thieme Verlag KG Stuttgart · New York.

  8. Emerging OP354-Like P[8] Rotaviruses Have Rapidly Dispersed from Asia to Other Continents.

    PubMed

    Zeller, Mark; Heylen, Elisabeth; Damanka, Susan; Pietsch, Corinna; Donato, Celeste; Tamura, Tsutomu; Kulkarni, Ruta; Arora, Ritu; Cunliffe, Nigel; Maunula, Leena; Potgieter, Christiaan; Tamim, Sana; Coster, Sarah De; Zhirakovskaya, Elena; Bdour, Salwa; O'Shea, Helen; Kirkwood, Carl D; Seheri, Mapaseka; Nyaga, Martin Monene; Mphahlele, Jeffrey; Chitambar, Shobha D; Dagan, Ron; Armah, George; Tikunova, Nina; Van Ranst, Marc; Matthijnssens, Jelle

    2015-08-01

    The majority of human group A rotaviruses possess the P[8] VP4 genotype. Recently, a genetically distinct subtype of the P[8] genotype, also known as OP354-like P[8] or lineage P[8]-4, emerged in several countries. However, it is unclear for how long the OP354-like P[8] gene has been circulating in humans and how it has spread. In a global collaborative effort 98 (near-)complete OP354-like P[8] VP4 sequences were obtained and used for phylogeographic analysis to determine the viral migration patterns. During the sampling period, 1988-2012, we found that South and East Asia acted as a source from which strains with the OP354-like P[8] gene were seeded to Africa, Europe, and North America. The time to the most recent common ancestor (TMRCA) of all OP354-like P[8] genes was estimated at 1987. However, most OP354-like P[8] strains were found in three main clusters with TMRCAs estimated between 1996 and 2001. The VP7 gene segment of OP354-like P[8] strains showed evidence of frequent reassortment, even in localized epidemics, suggesting that OP354-like P[8] genes behave in a similar manner on the evolutionary level as other P[8] subtypes. The results of this study suggest that OP354-like P[8] strains have been able to disperse globally in a relatively short time period. This, in combination with a relatively large genetic distance to other P[8] subtypes, might result in a lower vaccine effectiveness, underscoring the need for a continued surveillance of OP354-like P[8] strains, especially in countries where rotavirus vaccination programs are in place.

  9. 7 CFR 1944.663 - Ownership agreement between HPG grantee and rental property owner or co-op.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... property owner or co-op. 1944.663 Section 1944.663 Agriculture Regulations of the Department of Agriculture... Preservation Grants § 1944.663 Ownership agreement between HPG grantee and rental property owner or co-op. HPG assistance may be provided by a grantee with respect to rental properties or co-ops only if the...

  10. 7 CFR 1944.663 - Ownership agreement between HPG grantee and rental property owner or co-op.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... property owner or co-op. 1944.663 Section 1944.663 Agriculture Regulations of the Department of Agriculture... Preservation Grants § 1944.663 Ownership agreement between HPG grantee and rental property owner or co-op. HPG assistance may be provided by a grantee with respect to rental properties or co-ops only if the...

  11. 7 CFR 1944.663 - Ownership agreement between HPG grantee and rental property owner or co-op.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... property owner or co-op. 1944.663 Section 1944.663 Agriculture Regulations of the Department of Agriculture... Preservation Grants § 1944.663 Ownership agreement between HPG grantee and rental property owner or co-op. HPG assistance may be provided by a grantee with respect to rental properties or co-ops only if the...

  12. 7 CFR 1944.663 - Ownership agreement between HPG grantee and rental property owner or co-op.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... property owner or co-op. 1944.663 Section 1944.663 Agriculture Regulations of the Department of Agriculture... Preservation Grants § 1944.663 Ownership agreement between HPG grantee and rental property owner or co-op. HPG assistance may be provided by a grantee with respect to rental properties or co-ops only if the...

  13. 7 CFR 1944.663 - Ownership agreement between HPG grantee and rental property owner or co-op.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... property owner or co-op. 1944.663 Section 1944.663 Agriculture Regulations of the Department of Agriculture... Preservation Grants § 1944.663 Ownership agreement between HPG grantee and rental property owner or co-op. HPG assistance may be provided by a grantee with respect to rental properties or co-ops only if the...

  14. OpWise: Operons aid the identification of differentially expressedgenes in bacterial microarray experiments

    SciTech Connect

    Price, Morgan N.; Arkin, Adam P.; Alm, Eric J.

    2005-11-23

    Differentially expressed genes are typically identified by analyzing the variation between replicate measurements. These procedures implicitly assume that there are no systematic errors in the data even though several sources of systematic error are known. Results-OpWise estimates the amount of systematic error in bacterial microarray data by assuming that genes in the same operon have matching expression patterns. OpWise then performs a Bayesian analysis of a linear model to estimate significance. In simulations, OpWise corrects for systematic error and is robust to deviations from its assumptions. In several bacterial data sets, significant amounts of systematic error are present, and replicate-based approaches overstate the confidence of the changers dramatically, while OpWise does not. Finally, OpWise can identify additional changers by assigning genes higher confidence if they are consistent with other genes in the same operon. Although microarray data can contain large amounts of systematic error, operons provide an external standard and allow for reasonable estimates of significance. OpWise is available at http://microbesonline.org/OpWise.

  15. Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1.

    PubMed

    Wittmann, Torsten; Bokoch, Gary M; Waterman-Storer, Clare M

    2004-02-13

    In the leading edge of migrating cells, a subset of microtubules exhibits net growth in a Rac1- and p21-activated kinase-dependent manner. Here, we explore the possibility of whether phosphorylation and inactivation of the microtubule-destabilizing protein Op18/stathmin could be a mechanism regulating microtubule dynamics downstream of Rac1 and p21-activated kinases. We find that, in vitro, Pak1 phosphorylates Op18/stathmin specifically at serine 16 and inactivates its catastrophe promoting activity in biochemical and time lapse microscopy microtubule assembly assays. Furthermore, phosphorylation of either serine 16 or 63 is sufficient to inhibit Op18/stathmin in vitro. In cells, the microtubule-destabilizing effect of an excess of Op18/stathmin can be partially overcome by expression of constitutively active Rac1(Q61L), which is dependent on Pak activity, suggesting that the microtubule cytoskeleton can be regulated through inactivation of Op18/stathmin downstream of Rac1 and Pak in vivo. However, in vivo, Pak1 activity alone is not sufficient to phosphorylate Op18, indicating that additional pathways downstream of Rac1 are required for Op18 regulation.

  16. Therapeutic effects of OP-1 on metal wear particle induced osteoblasts injury in vitro.

    PubMed

    Sun, Guojing; Chen, Jianmin; Yang, Shufeng; Parker, Thomas Mn; Goodman, Gary Mp; Hasama, Jack M; Zhao, Jianning

    2015-01-01

    Aseptic lossening is a main reason for the revision of total joint arthroplasty. Metal-wear particles induced deregulation of bone resorption or formation has been considered as the major process of aseptic lossening. Osteogenic protein-1 (OP-1) can be used to improve bone formation. However, such effect is not clearly understood after the metal-wear particles injury. Here, we investigated the molecular mechanisms by which OP-1 regulates the activity of bone formation and anti-inflammatory after injury. Results showed that OP-1 increased cell viability and bone formation ability of impaired osteoblast cells at 72 hours after being injured by cobalt particles. Pathway analyses revealed that both mRNA and protein levels of Smad1 and Smad5 were significantly increased upon the treatment of OP-1 in the cell injury model. Similarly, runt-related transcription factor 2 (Runx2) was also significantly upregulated in the OP-1 treated cells. Moreover, treatment with OP-1 inhibited the secretion of interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), and IL-18 in cobalt impaired cells. Collectively, these results suggest that OP-1 could inhibit cobalt particles induced cell injury by activating Smad1, Smad5, and Runx2, and such procedure is accompanied by anti-inflammatory reaction.

  17. Safety of epidural administration of Osteogenic Protein-1 (OP-1/BMP-7): behavioral and macroscopic observation.

    PubMed

    Kawakami, Mamoru; Hashizume, Hiroshi; Matsumoto, Takuji; Enyo, Yoshio; Okada, Motohiro; Yoshida, Munehito; Chubinskaya, Susan

    2007-06-01

    To assess the safety of epidural administration of Osteogenic Protein-1 (OP-1). To examine if epidural administration of OP-1 or administration into the nucleus pulposus (NP) resulted in ectopic bone formation and/or pain-related behavior. OP-1 has the potential for treatment of degenerative disc disease. However, OP-1's safety, when it is applied into the epidural space or herniated nucleus pulposus, is not well established. Forty rats were divided into 5 groups. Sham group: Left L4 and L5 nerve roots were exposed. NP group: The NP obtained from the tail was relocated onto the exposed nerve roots. NP+OP group: The NP obtained from the tail and injected with 0.2 microg of OP-1 in 1 microL of 5% lactose-buffered solution was placed on the nerve roots. GS group: A gelatin sponge was applied on the nerve roots. GS+OP group: A gelatin sponge soaked with 0.2 microg of OP-1 in 1 microL of 5% lactose-buffered solution was placed onto the nerve roots. Motor function and reflex responses to mechanical noxious stimuli were measured in all rats up to 3 weeks after surgery. Three weeks after surgery, all rats were killed for analysis of ectopic bone formation and magnitude of neural compression. Motor paresis was not observed in any groups. Only rats in the NP group showed evidence of irreversible mechanical hyperalgesia after surgery. There were no differences in the mechanical stimuli response among all groups except the NP group. Macroscopic examination revealed no ectopic bone formation or differences in neural compression among the groups. OP-1 application in the epidural space is safe based on behavioral measures and macroscopic observation on ectopic bone formation at 21 days after surgery.

  18. ACK filling void first algorithm and performance for asynchronous OPS

    NASA Astrophysics Data System (ADS)

    Liu, Huanlin; Shi, Yonghe; Chen, Qianbin; Pan, Yingjun

    2007-11-01

    OPS with feedback shared FDL buffer produce large voids due to FDL buffers only supplying discrete step delay and causing FDL queue virtually occupation. By analyzing the TCP traffic and ACK packets feature, the ACK packet void filling first scheduling is presented to decrease packet loss rate and to reduce the FDL voids. When the FDL buffer void size is fit for the ACK packet, the ACK packet is scheduled to FDL immediately. An ACK and non-ACK packets difference and process flow is designed according the TCP packet frame structure. Compared with the conventional FIFO scheduling and smallest FDL void first scheduling, the algorithm reduces greatly the number of ACK occupying the FDL buffer and eliminates large numbers of ACK's bad influence on efficiency of IP data transmission under different FDL buffer depth and traffic load. The results of simulation show that the proposed scheduling makes use of ACK packets first void filling scheduling mechanism to reduce FDL excess load, increases output utilization and reduce packet loss ratio for asynchronous optical network. This approach is shown to minimize the FDL numbers with the feature of high stabilization and photonic integration and to improve real time TCP traffic performance for Internet network.

  19. Kauai Island Utility Co-op (KIUC) PV integration study.

    SciTech Connect

    Ellis, Abraham; Mousseau, Tom

    2011-08-01

    This report investigates the effects that increased distributed photovoltaic (PV) generation would have on the Kauai Island Utility Co-op (KIUC) system operating requirements. The study focused on determining reserve requirements needed to mitigate the impact of PV variability on system frequency, and the impact on operating costs. Scenarios of 5-MW, 10-MW, and 15-MW nameplate capacity of PV generation plants distributed across the Kauai Island were considered in this study. The analysis required synthesis of the PV solar resource data and modeling of the KIUC system inertia. Based on the results, some findings and conclusions could be drawn, including that the selection of units identified as marginal resources that are used for load following will change; PV penetration will displace energy generated by existing conventional units, thus reducing overall fuel consumption; PV penetration at any deployment level is not likely to reduce system peak load; and increasing PV penetration has little effect on load-following reserves. The study was performed by EnerNex under contract from Sandia National Laboratories with cooperation from KIUC.

  20. Op GRITROCK ethics; the way of things to come?

    PubMed

    Clay, Katherine A; Henning, J D; Horne, S

    2016-06-01

    The Defence Medical Services (DMS) deployed on Op GRITROCK to Sierra Leone in support of the Ebola outbreak. This operation was the first large-scale DMS deployment since operations in Afghanistan ceased at the end of 2014. This type of operation revealed a number of ethical issues and challenges that the DMS had not faced for a long time. The ethical issues identified during the deployment are discussed in this article using the principalism approach of Beauchamp and Childress. Many of these issues were not identified prior to deployment, and troops were not adequately prepared. The article will outline the difficulties of using the principles of autonomy, beneficence, non-maleficence and justice during a public health emergency, and conclude with recommendations for ethical considerations that should be identified and mitigated against for future deployments to a public health emergency. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  1. Looking at Op Art: Gaze stability and motion illusions

    PubMed Central

    Hermens, Frouke; Zanker, Johannes

    2012-01-01

    Various Op artists have used simple geometrical patterns to create the illusion of motion in their artwork. One explanation for the observed illusion involves retinal shifts caused by small involuntary eye movements that observers make while they try to maintain fixation. Earlier studies have suggested a prominent role of the most conspicuous of these eye movements, small rapid position shifts called microsaccades. Here, we present data that could expand this view with a different interpretation. In three experiments, we recorded participants' eye movements while they tried to maintain visual fixation when being presented with variants of Bridget Riley's Fall, which were manipulated such as to vary the strength of induced motion. In the first two experiments, we investigated the properties of microsaccades for a set of stimuli with known motion strengths. In agreement with earlier observations, microsaccade rates were unaffected by the stimulus pattern and, consequently, the strength of induced motion illusion. In the third experiment, we varied the stimulus pattern across a larger range of parameters and asked participants to rate the perceived motion illusion. The results revealed that motion illusions in patterns resembling Riley's Fall are perceived even in the absence of microsaccades, and that the reported strength of the illusion decreased with the number of microsaccades in the trial. Together, the three experiments suggest that other sources of retinal image instability than microsaccades, such as slow oculomotor drift, should be considered as possible factors contributing to the illusion. PMID:23145284

  2. The Vida Verde Women's Co-Op: Brazilian Immigrants Organizing to Promote Environmental and Social Justice

    PubMed Central

    Siqueira, Eduardo; Goldberg, Julia S.; Galvão, Heloisa; Chianelli, Mônica; Pirie, Alex

    2009-01-01

    We reviewed the key steps in the launch of the Vida Verde Women's Co-Op among Brazilian immigrant housecleaners in Somerville, MA. The co-op provides green housecleaning products, encourages healthy work practices, and promotes a sense of community among its members. We conducted in-depth interviews with 8 of the first co-op members, who reported a reduction in symptoms associated with the use of traditional cleaning agents and a new sense of mutual support. Critical to the co-op's success have been the supportive roles of its academic partners (Tufts University and the University of Massachusetts, Lowell), effective media outreach, and a focus on advancing social justice. Next steps include implementing a formal business plan and assessing the appropriateness of cooperatives in other industries. PMID:19890146

  3. The Vida Verde Women's Co-Op: Brazilian immigrants organizing to promote environmental and social justice.

    PubMed

    Gute, David M; Siqueira, Eduardo; Goldberg, Julia S; Galvão, Heloisa; Chianelli, Mônica; Pirie, Alex

    2009-11-01

    We reviewed the key steps in the launch of the Vida Verde Women's Co-Op among Brazilian immigrant housecleaners in Somerville, MA. The co-op provides green housecleaning products, encourages healthy work practices, and promotes a sense of community among its members. We conducted in-depth interviews with 8 of the first co-op members, who reported a reduction in symptoms associated with the use of traditional cleaning agents and a new sense of mutual support. Critical to the co-op's success have been the supportive roles of its academic partners (Tufts University and the University of Massachusetts, Lowell), effective media outreach, and a focus on advancing social justice. Next steps include implementing a formal business plan and assessing the appropriateness of cooperatives in other industries.

  4. Study on multiple-hops performance of MOOC sequences-based optical labels for OPS networks

    NASA Astrophysics Data System (ADS)

    Zhang, Chongfu; Qiu, Kun; Ma, Chunli

    2009-11-01

    In this paper, we utilize a new study method that is under independent case of multiple optical orthogonal codes to derive the probability function of MOOCS-OPS networks, discuss the performance characteristics for a variety of parameters, and compare some characteristics of the system employed by single optical orthogonal code or multiple optical orthogonal codes sequences-based optical labels. The performance of the system is also calculated, and our results verify that the method is effective. Additionally it is found that performance of MOOCS-OPS networks would, negatively, be worsened, compared with single optical orthogonal code-based optical label for optical packet switching (SOOC-OPS); however, MOOCS-OPS networks can greatly enlarge the scalability of optical packet switching networks.

  5. Three-photon absorption in optical parametric oscillators based on OP-GaAs

    NASA Astrophysics Data System (ADS)

    Heckl, Oliver H.; Bjork, Bryce J.; Winkler, Georg; Bryan Changala, P.; Spaun, Ben; Porat, Gil; Bui, Thinh Q.; Lee, Kevin F.; Jiang, Jie; Fermann, Martin E.; Schunemann, Peter G.; Ye, Jun

    2016-11-01

    We report on the first singly-resonant (SR), synchronously pumped optical parametric oscillator (OPO) based on orientation-patterned gallium arsenide (OP-GaAs). Together with a doubly resonant (DR) degenerate OPO based on the same OP-GaAs material, the output spectra cover 3 to 6 ${\\mu}$m within ~3 dB of relative power. The DR-OPO has the highest output power reported to date from a femtosecond, synchronously pumped OPO based on OP-GaAs. We discovered strong three photon absorption with a coefficient of 0.35 ${\\pm}$ 0.06 cm${^3}$/GW${^2}$ for our OP-GaAs sample, which limits the output power of these OPOs as mid-IR light sources. We present a detailed study of the three photon loss on the performance of both the SR and DR-OPOs, and compare them to those without this loss mechanism.

  6. An investigation of potential applications of OP-SAPS: Operational sampled analog processors

    NASA Technical Reports Server (NTRS)

    Parrish, E. A.; Mcvey, E. S.

    1976-01-01

    The impact of charge-coupled device (CCD) processors on future instrumentation was investigated. The CCD devices studied process sampled analog data and are referred to as OP-SAPS - operational sampled analog processors. Preliminary studies into various architectural configurations for systems composed of OP-SAPS show that they have potential in such diverse applications as pattern recognition and automatic control. It appears probable that OP-SAPS may be used to construct computing structures which can serve as special peripherals to large-scale computer complexes used in real time flight simulation. The research was limited to the following benchmark programs: (1) face recognition, (2) voice command and control, (3) terrain classification, and (4) terrain identification. A small amount of effort was spent on examining a method by which OP-SAPS may be used to decrease the limiting ground sampling distance encountered in remote sensing from satellites.

  7. Usefulness of the Co-op Experience: A Study of Community College Students.

    ERIC Educational Resources Information Center

    Krebs, Uwe (Hugh)

    1987-01-01

    Analyzes the perceived usefulness of the co-op experience of community college graduates from the Production and Operating Management and the Marketing Management programs at Centennial College in Ontario. (JOW)

  8. Common Post-Op Ear Drops Tied to Eardrum Perforations in Kids

    MedlinePlus

    ... gov/news/fullstory_164372.html Common Post-Op Ear Drops Tied to Eardrum Perforations in Kids Rate ... 2017 (HealthDay News) -- Children who suffer through multiple ear infections are often candidates for ear tube surgery. ...

  9. Structure, Properties, and Theoretical Electronic Structure of UCuOP and Np3S5.

    SciTech Connect

    Wells, Daniel M.; Ringe, Emilie; Kaczorowski, D.; Gnida, D.; Andre, G.; Haire, Richard {Dick} G; Ellis, Donald E.; Ibers, James A.

    2010-01-01

    The compounds UCuOP and NpCuOP have been synthesized and their crystal structures were determined from low-temperature single-crystal X-ray data. These isostructural compounds crystallize with two formula units in space group P4/nmm of the tetragonal system. Each An atom (An = U or Np) is coordinated to four O and four P atoms in a distorted square antiprism; each Cu atom is coordinated to four P atoms in a distorted tetrahedron. Magnetic susceptibility measurements on crushed single crystals indicate that UCuOP orders antiferromagnetically at 224(2) K. Neutron diffraction experiments at 100 and 228 K show the magnetic structure of UCuOP to be type AFI ( - -) where ferromagnetically aligned sheets of U atoms in the (001) plane order antiferromagnetically along [001]. The electrical conductivity of UCuOP exhibits metallic character. Its electrical resistivity measured in the ordered region with the current flowing within the tetragonal plane is governed by the scattering of the conduction electrons on antiferromagnetic spin-wave excitations. The electrical resistivity of single-crystalline NpCuOP shows semimetallic character. It is dominated by a pronounced hump at low temperatures, which likely arises owing to long-range magnetic ordering below about 90 K. Density of state analyses using the local spin-density approximation show covalent overlap between AnO and CuP layers of the structure and dominant contributions from 5f-actinide orbitals at the Fermi level. Calculations on a 2 2 2 supercell of NpCuOP show ferromagnetic ordering within the Np sheets and complex coupling between these planes. Comparisons of the physical properties of these AnCuOP compounds are made with those of the family of related tetragonal uranium phosphide compounds.

  10. Results of Investigations Concerning the Capabilities of the OpScan 100DM Optical Scanner.

    ERIC Educational Resources Information Center

    Gibbs, Gordon L.; Hooper, Judith

    A series of tests using OpScan 100DM optical scanner were carried out to determine whether it can mechanically transport paper that does not comply with the manufacturer's specifications for weight and size and see if standard paper stock has sufficient quality, opacity, and brightness to permit it to be used to print forms for the OpScan 100DM.…

  11. Creature co-op: Achieving robust remote operations with a community of low-cost robots

    NASA Technical Reports Server (NTRS)

    Bonasso, R. Peter

    1990-01-01

    The concept is advanced of carrying out space based remote missions using a cooperative of low cost robot specialists rather than monolithic, multipurpose systems. A simulation is described wherein a control architecture for such a system of specialists is being investigated. Early results show such co-ops to be robust in the face of unforeseen circumstances. Descriptions of the platforms and sensors modeled and the beacon and retriever creatures that make up the co-op are included.

  12. Results of Investigations Concerning the Capabilities of the OpScan 100DM Optical Scanner.

    ERIC Educational Resources Information Center

    Gibbs, Gordon L.; Hooper, Judith

    A series of tests using OpScan 100DM optical scanner were carried out to determine whether it can mechanically transport paper that does not comply with the manufacturer's specifications for weight and size and see if standard paper stock has sufficient quality, opacity, and brightness to permit it to be used to print forms for the OpScan 100DM.…

  13. OpEx - a validated, automated pipeline optimised for clinical exome sequence analysis

    PubMed Central

    Ruark, Elise; Münz, Márton; Clarke, Matthew; Renwick, Anthony; Ramsay, Emma; Elliott, Anna; Seal, Sheila; Lunter, Gerton; Rahman, Nazneen

    2016-01-01

    We present an easy-to-use, open-source Optimised Exome analysis tool, OpEx (http://icr.ac.uk/opex) that accurately detects small-scale variation, including indels, to clinical standards. We evaluated OpEx performance with an experimentally validated dataset (the ICR142 NGS validation series), a large 1000 exome dataset (the ICR1000 UK exome series), and a clinical proband-parent trio dataset. The performance of OpEx for high-quality base substitutions and short indels in both small and large datasets is excellent, with overall sensitivity of 95%, specificity of 97% and low false detection rate (FDR) of 3%. Depending on the individual performance requirements the OpEx output allows one to optimise the inevitable trade-offs between sensitivity and specificity. For example, in the clinical setting one could permit a higher FDR and lower specificity to maximise sensitivity. In contexts where experimental validation is not possible, minimising the FDR and improving specificity may be a preferable trade-off for slightly lower sensitivity. OpEx is simple to install and use; the whole pipeline is run from a single command. OpEx is therefore well suited to the increasing research and clinical laboratories undertaking exome sequencing, particularly those without in-house dedicated bioinformatics expertise. PMID:27485037

  14. Use of OpdA, an Organophosphorus (OP) Hydrolase, Prevents Lethality in an African Green Monkey Model of Acute OP Poisoning

    PubMed Central

    Jackson, Colin J; Carville, Angela; Ward, Jeanine; Mansfield, Keith; Ollis, David L.; Khurana, Tejvir; Bird, Steven B.

    2014-01-01

    Organophosphorus (OP) pesticides are a diverse class of acetylcholinesterase (AChE) inhibitors that are responsible for tremendous morbidity and mortality worldwide, killing approximately 300,000 people annually. Enzymatic hydrolysis of OPs is a potential therapy for acute poisoning. OpdA, an OP hydrolase isolated from Agrobacterium radiobacter, has been shown to decrease lethality in rodent models of OP poisoning. This study investigated the effects of OpdA on AChE activity, plasma concentrations of OP, and signs of toxicity after administration of dichlorvos to nonhuman primates. A dose of 75 mg/kg dichlorvos given orally caused apnea within 10 minutes with a progressive decrease in heart rate. Blood AChE activity decreased to zero within ten minutes. Respirations and AChE activity did not recover. The mean dichlorvos concentration rose to a peak of 0.66 μg/ml. Treated monkeys received 1.2 mg/kg OpdA iv immediately after poisoning with dichlorvos. In Opda-treated animals, heart and respiratory rates were unchanged from baseline over a 240-minute observation period. AChE activity slowly declined, but remained above 25% of baseline for the entire duration. Dichlorvos concentrations reached a mean peak of 0.19 μg/ml at 40 minutes after poisoning and decreased to a mean of 0.05 μg/ml at 240 minutes. These results show that OpdA hydrolyzes dichlorvos in an African Green Monkey model of lethal poisoning, delays AChE inhibition, and prevents lethality. PMID:24447378

  15. The Success and Failure of a Radiology Quality Metric: The Case of OP-10.

    PubMed

    Blackmore, C Craig; Watt, Douglas; Sicuro, Paul L

    2016-06-01

    Medical quality metrics can serve various functions, including promoting quality improvement efforts within a medical system, and providing a basis for comparing quality among institutions. OP-10, an imaging efficiency quality measure based on the number of CT scans of the abdomen performed both with and without contrast is broadly used and publically reported, but it has not been investigated in actual practice. In this project, we report on both a successful quality improvement effort built around measurement of OP-10, and on the identified potential limitations of OP-10 itself for comparing among institutions. We performed two quality improvement interventions in 2012 and 2014 directed at OP-10, encompassing building of institutional practice standards via creating multidisciplinary consensus, educating radiologists and clinicians, revising CT protocols, and providing performance measurement and feedback. Results were extracted from the radiology information system and analyzed using interrupted time series segmented regression and statistical process control charts. The proportion of inappropriate abdominal CT scans with and without contrast under OP-10 decreased, from 3,041 of 13,855 (21.9%) to 691 of 6,006 (11.5%) (P < .0001). However, 262 of 691 (37.8%) of the CT scans labeled as potential overuse by OP-10 could be considered appropriate under national guidelines. These discordant cases clustered in specific clinical areas (eg, urology and hepatology), indicating potential for bias against centers that serve referral populations in these areas. We conclude that OP-10 can be useful to drive internal quality improvement efforts but is potentially biased when used for interinstitutional comparisons. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  16. Expert systems built by the Expert: An evaluation of OPS5

    NASA Technical Reports Server (NTRS)

    Jackson, Robert

    1987-01-01

    Two expert systems were written in OPS5 by the expert, a Ph.D. astronomer with no prior experience in artificial intelligence or expert systems, without the use of a knowledge engineer. The first system was built from scratch and uses 146 rules to check for duplication of scientific information within a pool of prospective observations. The second system was grafted onto another expert system and uses 149 additional rules to estimate the spacecraft and ground resources consumed by a set of prospective observations. The small vocabulary, the IF this occurs THEN do that logical structure of OPS5, and the ability to follow program execution allowed the expert to design and implement these systems with only the data structures and rules of another OPS5 system as an example. The modularity of the rules in OPS5 allowed the second system to modify the rulebase of the system onto which it was grafted without changing the code or the operation of that system. These experiences show that experts are able to develop their own expert systems due to the ease of programming and code reusability in OPS5.

  17. Realization of the new UTC(OP) based on the LNE-SYRTE atomic fountains

    NASA Astrophysics Data System (ADS)

    Chupin, B.; Bize, S.; Guéna, J.; Laurent, P.; Rosenbusch, P.; Uhrich, P.; Abgrall, M.; Rovera, G.

    2014-12-01

    For many years, UTC(OP), the real-time approximation of UTC built in LNE-SYRTE, Observatoire de Paris (OP), Paris, France, had been based on industrial Cesium (Cs) standards [1]. Since October 2012, new algorithm for the generation of UTC(OP) has been put in operation. It is based on the steering of a H-maser signal on the LNE-SYRTE Primary Frequency Standards. The current OP atomic fountain ensemble comprises a Cs fountain called FO1, a dual fountain working with Cs and Rubidium (Rb) atoms called FO2, and a mobile Cs fountain called FOM. All fountains share the same cryogenic oscillator which is phase locked to a H-maser, so that all fountains measure the frequency of the same H-maser. Automatic fountain data processing provides hourly preliminary data corrected of all systematic frequency shifts. The steering of the H-maser frequency is calculated daily by a fit to the fountain data. First we describe the implementation of all the instruments used for the generation of UTC(OP) together with the current version of the algorithm. The choice of this algorithm has been oriented to obtain robustness of the system instead of the ultimate optimization of performances. We then present the results obtained during the first year of operation.

  18. Differential accumulation levels in the brain of rats exposed to the endocrine disruptor 4-tert-octylphenol (OP).

    PubMed

    Bianco, M; Mita, L; Portaccio, M; Diano, N; Sica, V; De Luca, B; Mita, D G; Carratelli, C Romano; Viggiano, E

    2011-01-01

    Octylphenol (OP) is an endocrine-disrupting chemical that accumulates in various organs. It has also been shown to exert noxious effects on the central nervous system. In the present study, we measured in Sprague-Dawley rats the degree of OP accumulation in different areas of the brain and investigated the effect of OP in pain modulation. Two groups of male Sprague-Dawley rats were treated for 20 days with 50mg/kg BW/day of OP (group 1) or vehicle (group 2). At the end of the treatment, the formalin test was performed to evaluate the effect of OP exposure on pain. Soon after, rats were sacrificed, and the accumulation of OP in the cerebral cortex, hippocampus, hypothalamus, cerebellum, thalamus, striatum, mesencephalus and ventral hindbrain was measured by HPLC analysis. The results showed a greater accumulation of OP in the cerebral cortex compared to all the other areas; there was also more accumulation in the cerebellum compared to the mesencephalus and thalamus. No accumulation was found in the striatum. These results suggest that there is a preferential accumulation of OP in different areas of the brain with consequences to neural behaviour. On the contrary, experiments on facial grooming did not show significant effects of OP on pain. Copyright © 2010 Elsevier B.V. All rights reserved.

  19. Correction by CSF-1 of defects in the osteopetrotic op/op mouse suggests local, developmental, and humoral requirements for this growth factor.

    PubMed

    Wiktor-Jedrzejczak, W; Urbanowska, E; Aukerman, S L; Pollard, J W; Stanley, E R; Ralph, P; Ansari, A A; Sell, K W; Szperl, M

    1991-11-01

    Mice that are mutant at the op locus have a severe deficiency of mononuclear phagocytes due to an inactivating mutation in the CSF-1 (macrophage colony-stimulating factor, M-CSF) gene. op/op mice are toothless, possessing skeletal abnormalities, a low body weight, and compromised fertility; they are osteopetrotic due to a deficiency of osteoclasts. The congenital osteopetrosis, toothless phenotype, osteoclast deficit, and the defects in splenic and femoral macrophages were corrected by routes of administration of human recombinant CSF-1 that maintained normal circulating CSF-1 concentrations. Early restoration of circulating CSF-1 was required for rescue of the toothless phenotype, but only partially restored body weight. In contrast, the deficiencies of pleural and peritoneal cavity macrophages and the reduced female fertility were not corrected by restoration of circulating CSF-1. These results suggest that although circulating CSF-1 is required for osteoclast and macrophage production, local synthesis and action of the growth factor are important for certain target cell populations.

  20. Status of the Signals of Opportunity Airborne Demonstrator (SoOp-AD)

    NASA Technical Reports Server (NTRS)

    Garrison, Jim; Lin, Yao-Cheng; Piepmeier, Jeff; Knuble, Joe; Hersey, Ken; Du Toit, Cornelus; Joseph, Alicia; Deshpande, Manohar; Alikakos, George; O'Brien, Steve; hide

    2016-01-01

    Root zone soil moisture (RZSM) is not directly measured by any current satellite instrument, despite its importance as a key link between surface hydrology and deeper processes. Presently, model assimilation of surface measurements or indirect estimates using other methods must be used to estimate this value. Signals of Opportunity (SoOp) methods, exploiting reflected P- and S-band communication satellite signals, have many of the benefits of both active and passive microwave remote sensing. Reutilization of active transmitters, with forward-scattering geometry, presents a strong reflected signal even at orbital altitudes. Microwave radiometry is advantageous as it measures emissivity, which is directly related to dielectric constant and sensitive to water content of soil. Synthetic aperture radar (SAR) is used in P-band (400 MHz) for soil moisture and biomass, but faces issues in obtaining permission to transmit due to spectrum regulations, particularly over North America and Europe. A primary advantage of SAR is excellent spatial resolution. Signals-of-opportunity (SoOp) reflectometry provides a good compromise between radiometry and SAR by providing decent sensitivity and special resolution for RZSM measurements without issues of spectrum access. Further, a SoOp instrument would not be limited to operating in only a few protected frequencies and is also expected to have less susceptibility to radio-frequency interference (RFI). Although advantageous if available, SoOp techniques do not require the ability to demodulate or decode the communication signals. The SoOp instrument is receive only and therefore requires much less electrical power than a SAR and is more similar to a radiometer in receiver architecture. These unique features of SoOp circumvent past obstacles to a spaceborne P-band remote sensing mission and have the potential to enable new RZSM measurements that are not possible with present technology. We will present the latest development status of a

  1. Small molecule activation by POC(sp3)OP-nickel complexes.

    PubMed

    Hao, Jingjun; Vabre, Boris; Mougang-Soumé, Berline; Zargarian, Davit

    2014-09-22

    This contribution describes the reactivities of CO2 , CO, O2 , and ArNC with the pincer-type complexes [(κ(P) ,κ(C) ,κ(P') -POC sp 3OP)NiX] (POC sp 3OP=(R2 POCH2 )2 CH; R=iPr; X=OSiMe3 , NArH; Ar=2,6-iPr2 C6 H3 ). Reaction of the amido derivative with CO2 and CO leads to a simple insertion into the NiN bond to give stable carbamate and carbamoyl derivatives, respectively, the pincer ligand backbone remaining intact in both cases. In contrast, the analogous reactions with the siloxide derivative produced kinetically labile insertion products that either revert to the starting material (in the case of CO2 ) or react further to give the mixed-valent, dinickel species [(POC sp 3OP)Ni(II) {μ,κ(O) ,κ(P) ,κ(P') -OCOCH(CH2 CH2 OPR2 )2 }Ni(0) (CO)2 ]. The zero-valent center in the latter compound is ligated by a new ligand arising from transformation of the POC sp 3OP ligand backbone. The carbonylation and carboxylation of the siloxido derivative also produced minor quantities of a side-product identified as the trinickel species, [{(η(3) -allyl)Ni(μ(O) ,κ(P) -R2 PO)2 }2 Ni], arising from total dismantling of the POC sp 3OP ligand. Similar reactivities were observed with isonitrile, ArNC: reaction with the siloxido derivative resulted in a complex sequence of steps involving initial insertion, a 1,3-hydrogen shift, and an Arbuzov rearrangement to give [Ni(CNAr)4 ] and a methacrylamide based on fragments of the POC sp 3OP ligand. Oxygenation of the amido and siloxido derivatives led to the phosphinate derivative, [(POC sp 3OP)Ni(OP(O)R2 )], arising from oxidative transformation of the original ligand frame; the reaction with the Ni-NHAr derivative also gave ArHNP(O)R2 through a complex NP bond-forming reaction.

  2. Examining the Influence of Selected Factors on Perceived Co-Op Work-Term Quality from a Student Perspective

    ERIC Educational Resources Information Center

    Drewery, David; Nevison, Colleen; Pretti, T. Judene; Cormier, Lauren; Barclay, Sage; Pennaforte, Antoine

    2016-01-01

    This study discusses and tests a conceptual model of co-op work-term quality from a student perspective. Drawing from an earlier exploration of co-op students' perceptions of work-term quality, variables related to role characteristics, interpersonal dynamics, and organizational elements were used in a multiple linear regression analysis to…

  3. 76 FR 12740 - Public Meeting of the Consumer Operated and Oriented Plan (CO-OP) Advisory Board; Meeting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... Oriented Plan (CO-OP) Advisory Board; Meeting Location Change AGENCY: Centers for Medicare & Medicaid Services (CMS), HHS. ACTION: Notice of meeting location change. SUMMARY: This notice announces the change of location of the March 14, 2011, public meeting of the Consumer Operated and Oriented Plan (CO-OP...

  4. 26 CFR 1.501(c)(29)-1T - CO-OP Health Insurance Issuers (temporary).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 7 2014-04-01 2013-04-01 true CO-OP Health Insurance Issuers (temporary). 1.501(c)(29)-1T Section 1.501(c)(29)-1T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... CO-OP Health Insurance Issuers (temporary). (a) Organizations must notify the Commissioner that...

  5. 26 CFR 1.501(c)(29)-1T - CO-OP Health Insurance Issuers (temporary).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 7 2013-04-01 2013-04-01 false CO-OP Health Insurance Issuers (temporary). 1.501(c)(29)-1T Section 1.501(c)(29)-1T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... CO-OP Health Insurance Issuers (temporary). (a) Organizations must notify the Commissioner that...

  6. 26 CFR 1.501(c)(29)-1T - CO-OP Health Insurance Issuers (temporary).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 7 2012-04-01 2012-04-01 false CO-OP Health Insurance Issuers (temporary). 1.501(c)(29)-1T Section 1.501(c)(29)-1T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... CO-OP Health Insurance Issuers (temporary). (a) Organizations must notify the Commissioner that...

  7. Kononenko conducts a session of the Russian MedOps Assessment MO-12

    NASA Image and Video Library

    2012-02-21

    ISS030-E-078132 (21 Feb. 2012) --- Russian cosmonaut Oleg Kononenko, Expedition 30 flight engineer, conducts a session of the Russian MedOps assessment MO-12 (Study of the Veins in the Lower Extremities), using the KARDIOMED (Cardiomed) complex with orthogonal leads in the Zvezda Service Module of the International Space Station.

  8. 75 FR 16874 - Market Test of “Samples Co-Op Box” Experimental Product

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... From the Federal Register Online via the Government Publishing Office POSTAL SERVICE Market Test...: The Postal Service gives notice of a market test of an experimental product in accordance with...) that it will begin a market test of its ``Samples Co-Op Box'' experimental product on May 1, 2010. The...

  9. A Longitudinal Study of the CO-OP Upward Bound Program 2003-2008

    ERIC Educational Resources Information Center

    Henderson, Sharmakrenia D.

    2009-01-01

    This longitudinal case study examined the effectiveness of the CO-OP Upward Bound Program activities from 2003 through 2008 applying cultural and social capital theories. The program was evaluated in order to give a local perspective to program implementation and operations in a community-based setting. The participant researcher used mixed…

  10. Developing the Conditions for Co-Op Students' Organizational Commitment through Cooperative Education

    ERIC Educational Resources Information Center

    Pennaforte, Antoine; Pretti, T. Judene

    2015-01-01

    Based in a French context, this research investigates the link between the French cooperative education (co-op) system and students' organizational commitment. Following a quasi-experimental design with a control group, in a longitudinal approach, the study focuses on under-baccalaureate, undergraduate and graduate students. Results show that in…

  11. Comparison of Total Dose Effects on Micropower Op-Amps: Bipolar and CMOS

    NASA Technical Reports Server (NTRS)

    Lee, C.; Johnston, A.

    1998-01-01

    This paper compares low-paper op-amps, OPA241 (bipolar) and OPA336 (CMOS), from Burr-Brown, MAX473 (bipolar) and MAX409 (CMOS), characterizing their total dose response with a single 2.7V power supply voltage.

  12. Comparison of Total Dose Effects on Micropower Op-Amps: Bipolar and CMOS

    NASA Technical Reports Server (NTRS)

    Lee, C.; Johnston, A.

    1998-01-01

    This paper compares low-paper op-amps, OPA241 (bipolar) and OPA336 (CMOS), from Burr-Brown, MAX473 (bipolar) and MAX409 (CMOS), characterizing their total dose response with a single 2.7V power supply voltage.

  13. An investigation of potential applications of OP-SAPS: Operational Sampled Analog Processors

    NASA Technical Reports Server (NTRS)

    Parrish, E. A.; Mcvey, E. S.

    1977-01-01

    The application of OP-SAP's (operational sampled analog processors) in pattern recognition system is summarized. Areas investigated include: (1) human face recognition; (2) a high-speed programmable transversal filter system; (3) discrete word (speech) recognition; and (4) a resolution enhancement system.

  14. Three-photon absorption in optical parametric oscillators based on OP-GaAs.

    PubMed

    Heckl, Oliver H; Bjork, Bryce J; Winkler, Georg; Bryan Changala, P; Spaun, Ben; Porat, Gil; Bui, Thinh Q; Lee, Kevin F; Jiang, Jie; Fermann, Martin E; Schunemann, Peter G; Ye, Jun

    2016-11-15

    We report on, to the best of our knowledge, the first singly resonant (SR), synchronously pumped optical parametric oscillator (OPO) based on orientation-patterned gallium arsenide (OP-GaAs). Together with a doubly resonant (DR) degenerate OPO based on the same OP-GaAs material, the output spectra cover 3 to 6 μm within ∼3  dB of relative power. The DR-OPO has the highest output power reported to date from a femtosecond, synchronously pumped OPO based on OP-GaAs. We observed strong three-photon absorption with a coefficient of 0.35±0.08  cm3/GW2 for our OP-GaAs sample, which limits the output power of these OPOs as mid-IR light sources. We present a detailed study of the three-photon loss on the performance of both the SR- and DR-OPOs, and compare them to those without this loss mechanism.

  15. Evaluation of Employer, Teacher, and Student Perceptions of CO-OP/PEL. Final Report.

    ERIC Educational Resources Information Center

    Hogue, Ken; And Others

    A study compared the effectiveness of on-the-job work experience (CO-OP) with pre-employment laboratory experience (PEL) of the six instructional areas in vocational education. This was accomplished by obtaining the perceptions of program completers (1983 graduates), participating employers, and vocational education teachers from seven sample…

  16. Vocational Education/JTPA Teamwork: Four Working Co-op Models.

    ERIC Educational Resources Information Center

    Steinberg, Neil; Kaleda, Paul

    1986-01-01

    Examines a proposal utilizing a series of models that enable Service Delivery Areas to provide eligible in-school youth with JTPA (Job Partnership Training Act) services through the schools' vocational co-op programs. Describes goals, delivery system, accomplished objectives, and benefits to the student, service delivery area, school district,…

  17. 49 CFR 365.105 - Starting the application process: Form OP-1.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Starting the application process: Form OP-1. 365.105 Section 365.105 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL... REGULATIONS RULES GOVERNING APPLICATIONS FOR OPERATING AUTHORITY How To Apply for Operating Authority § 365...

  18. Co-Op Students' Access to Shared Knowledge in Science-Rich Workplaces

    ERIC Educational Resources Information Center

    Munby, Hugh; Taylor, Jennifer; Chin, Peter; Hutchinson, Nancy L.

    2007-01-01

    Wenger's (1998) concepts "community of practice," "brokering," and "transfer" explain the challenges co-operative (co-op) education students face in relating the knowledge learned in school with what they learn while participating as members of a workplace. The research for this paper is set within the contexts of the knowledge economy and…

  19. Unified study of Quality of Service (QoS) in OPS/OBS networks

    NASA Astrophysics Data System (ADS)

    Hailu, Dawit Hadush; Lema, Gebrehiwet Gebrekrstos; Yekun, Ephrem Admasu; Kebede, Samrawit Haylu

    2017-07-01

    With the growth of Internet traffic, an inevitable use of optical networks provide a large bandwidth, fast data transmission rates and Quality of Service (QoS) support. Currently, Optical Burst Switched (OBS)/Optical Packet Switched (OPS) networks are under study as future solutions for addressing the increase demand of Internet traffic. However, due to their high blocking probability in the intermediate nodes they have been delayed in the industries. Packet loss in OBS/OPS networks is mainly occur due to contention. Hence, the contribution of this study is to analyze the file loss ratio (FLR), packet overhead and number of disjoint paths, and processing delay over Coded Packet Transport (CPT) scheme for OBS/OPS network using simulation. The simulations show that CPT scheme reduces the FLR in OBS/OPS network for the evaluated scenarios since the data packets are chopped off into blocks of the data packet for transmission over a network. Simulation results for secrecy and survivability are verified with the help of the analytical model to define the operational range of CPT scheme.

  20. Implementing a Multiple Criteria Model Base in Co-Op with a Graphical User Interface Generator

    DTIC Science & Technology

    1993-09-23

    Decision Support System (Co-op) for Windows. The algorithms and the graphical user interfaces for these modules are implemented using Microsoft Visual ... Basic under the Windows based environment operating in a IBM compatible microcomputer. Design of the MCDM programs interface is based on general interface design principles of user control, screen design, and layout.

  1. Evaluating Cumulative OP Pesticide Body Burden of Children: A National Case Study

    PubMed Central

    Payne-Sturges, Devon; Cohen, Jonathan; Castorina, Rosemary; Axelrad, Daniel A.; Woodruff, Tracey J.

    2009-01-01

    Biomonitoring is a valuable tool for identifying exposures to chemicals that pose potential harm to human health. However, to date there has been little published on ways to evaluate the relative public health significance of biomonitoring data for different chemicals, and even less on cumulative assessment of multiple chemicals. The objectives of our study are to develop a methodology for a health risk interpretation of biomonitoring data, and to apply it using NHANES 1999–2002 body burden data for organophosphorus (OP) pesticides. OP pesticides present a particularly challenging case given the non-specificity of many metabolites monitored through NHANES. We back-calculate OP pesticide exposures from urinary metabolite data, and compare cumulative dose estimates with available toxicity information for a common mechanism of action (brain cholinesterase inhibition) using data from U.S. EPA. Our results suggest that approximately 40% of children in the United States may have had insufficient margins of exposure (MOEs) for neurological impacts from cumulative exposures to OP pesticides (MOE less than 1,000). Limitations include uncertainty related to assumptions about likely precursor pesticide compounds of the urinary metabolites, sources of exposure, and intra-individual and temporal variability. PMID:19921915

  2. Exposure to organophosphate (OP) pesticides and health conditions in agricultural and non-agricultural workers from Maule, Chile.

    PubMed

    Muñoz-Quezada, María Teresa; Lucero, Boris; Iglesias, Verónica; Levy, Karen; Muñoz, María Pía; Achú, Eduardo; Cornejo, Claudia; Concha, Carlos; Brito, Ana María; Villalobos, Marcos

    2017-02-01

    The objective was to evaluate the characteristics of exposure to OP pesticides and health status in Chilean farm workers from the Maule Region. An occupational health questionnaire was administered in 207 agricultural and non-agricultural workers. For the group of agricultural workers, we asked about specific occupational exposure history and symptoms of OP pesticide poisoning. The main health problem of the exposed group was previous OP pesticide poisoning (p < 0.001). Fifty-six percent of agricultural workers reported symptoms consistent with acute OP pesticide poisoning. The use of respiratory personal protective equipment and younger age were protective against these symptoms, and number of years of OP pesticide exposure was positively associated with reporting symptoms of poisoning. Of the pesticide applicators 47 % reported using chlorpyrifos. The regulations regarding use and application of pesticides should be strengthened, as should training and intervention with workers to improve the use of personal protective equipment.

  3. Experimental implementation of edge nodes for an OPS system based on Nios II

    NASA Astrophysics Data System (ADS)

    Li, Xiaoyun; Xu, Bo; Qiu, Kun; Zhou, Heng

    2008-12-01

    The advantages of Optical Packet Switching (OPS) are transparent data transmission and data format, flexible packet control and dynamic resource allocation. It thus can support high-speed transmission of wideband data networks. Unlike Optical Burst Switching (OBS) systems which need reserved channel to transmit destination address, an advanced OPS solution using Optical Orthogonal Code (OOC) label for payload transfer has been proposed in this paper. Different from other OPS systems, our edge nodes are required to realize some special tasks including extracting destination addresses of the received IP packet which is used as payload in our OPS systems and sending the addresses to the OOC label generator. The OOC label will later be used to identify the destination of each payload at the core node for optical switching. Meanwhile, the higher-priority flow can be prior-serviced according to the Type of Service (TOS) in the head of IP packet. It is experimentally shown that the edge nodes in this OPS system can effectively improve the efficiency of packet switching and the speed of data transmission. The edge node implementation contains two parts: the hardware and software. For the hardware part, all necessary modules have been integrated onto one PCB board, thus avoiding possible instability caused by interconnecting different modules like transmitting/receiving Ethernet frame module, Field Programmable Gate Array (FPGA) processing module and optical transceiver module etc. from different Printed Circuit Boards (PCB). For the software part, the whole of system was based on MicroC/OS-II operating systems running on the Nios II soft core processor. It is verified by the experiment that embedded system designed with Nios II soft core CPU can help to speed up the hardware design. With the SOPC Builder's development environment, more attention can be paid to the structure and function of the system without worrying about the details of the circuit design, and better

  4. Signals of Opportunity Earth Reflectometry (SoOp-ER): Enabling new microwave observations from small satellites

    NASA Astrophysics Data System (ADS)

    Garrison, J. L.; Piepmeier, J. R.; Shah, R.; Lin, Y. C.; Du Toit, C. F.; Vega, M. A.; Knuble, J. J.

    2016-12-01

    Several recent experiments have demonstrated remote sensing by reutilizing communication satellite transmissions as sources in a bistatic radar configuration. This technique, referred to as "Signals of Opportunity Earth Reflectometry" (SoOp-ER), combines aspects of passive radiometry, active scatterometry and radar altimetry, but is essentially a new and alternative approach to microwave remote sensing. Reflectometry was first demonstrated with Global Navigation Satellite System (GNSS) signals, enabled by their use of pseudorandom noise (PRN) codes for ranging. Two decades of research in GNSS reflectometry has culminated in the upcoming launches of several satellite missions within the next few years (TechDemoSat-1, CYGNSS, and GEROS-ISS). GNSS signals, however, have low power and are confined to a few L-band frequencies allocated to radionavigation. Communication satellites, in contrast, transmit in nearly all bands penetrating the Earth's atmosphere at very high radiated powers to assure a low bit-error-rate. High transmission power and a forward scatter geometry result in a very high signal to noise ratio at the receiver. Surface resolution is determined by the signal bandwidth, not the antenna beam. In many applications, this will allow small, low gain antennas to be used to make scientifically useful measurements. These features indicate that SoOp-ER instruments would be an ideal technology for microwave remote sensing from small platforms. SoOp-ER observations are referenced at the specular point and a constellation of small satellites, evenly spaced in the same orbit, would provide global coverage through parallel specular point ground tracks. This presentation will summarize the current instrument development work by the authors on three different application of SoOp-ER: P-band (230-270 MHz) sensing of root-zone soil moisture (RZSM), S-band sensing of ocean winds and Ku/Ka-band altimetry. Potential mission scenarios using small satellite constellations

  5. Eye movement instructions modulate motion illusion and body sway with Op Art

    PubMed Central

    Kapoula, Zoï; Lang, Alexandre; Vernet, Marine; Locher, Paul

    2015-01-01

    Op Art generates illusory visual motion. It has been proposed that eye movements participate in such illusion. This study examined the effect of eye movement instructions (fixation vs. free exploration) on the sensation of motion as well as the body sway of subjects viewing Op Art paintings. Twenty-eight healthy adults in orthostatic stance were successively exposed to three visual stimuli consisting of one figure representing a cross (baseline condition) and two Op Art paintings providing sense of motion in depth—Bridget Riley’s Movements in Squares and Akiyoshi Kitaoka’s Rollers. Before their exposure to the Op Art images, participants were instructed either to fixate at the center of the image (fixation condition) or to explore the artwork (free viewing condition). Posture was measured for 30 s per condition using a body fixed sensor (accelerometer). The major finding of this study is that the two Op Art paintings induced a larger antero-posterior body sway both in terms of speed and displacement and an increased motion illusion in the free viewing condition as compared to the fixation condition. For body sway, this effect was significant for the Riley painting, while for motion illusion this effect was significant for Kitaoka’s image. These results are attributed to macro-saccades presumably occurring under free viewing instructions, and most likely to the small vergence drifts during fixations following the saccades; such movements in interaction with visual properties of each image would increase either the illusory motion sensation or the antero-posterior body sway. PMID:25859197

  6. Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcome drug resistance in myeloid leukemia

    PubMed Central

    Agarwal, Anupriya; MacKenzie, Ryan J.; Pippa, Raffaella; Eide, Christopher A.; Oddo, Jessica; Tyner, Jeffrey W.; Sears, Rosalie; Vitek, Michael P.; Odero, María D.; Christensen, Dale; Druker, Brian J.

    2014-01-01

    Purpose The SET oncoprotein, a potent inhibitor of the protein phosphatase 2A (PP2A), is overexpressed in leukemia. We evaluated the efficacy of SET antagonism in chronic myeloid leukemia (CML) and acute myeloid leukemia (AML) cell lines, a murine leukemia model, and primary patient samples using OP449, a specific, cell-penetrating peptide that antagonizes SET's inhibition of PP2A. Experimental Design In vitro cytotoxicity and specificity of OP449 in CML and AML cell lines and primary samples were measured using proliferation, apoptosis and colonogenic assays. Efficacy of target inhibition by OP449 is evaluated by immunoblotting and PP2A assay. In vivo antitumor efficacy of OP449 was measured in human HL-60 xenografted murine model. Results We observed that OP449 inhibited growth of CML cells including those from patients with blastic phase disease and patients harboring highly drug-resistant BCR-ABL1 mutations. Combined treatment with OP449 and ABL1 tyrosine kinase inhibitors was significantly more cytotoxic to K562 cells and primary CD34+ CML cells. SET protein levels remained unchanged with OP449 treatment, but BCR-ABL1-mediated downstream signaling was significantly inhibited with the degradation of key signaling molecules such as BCR-ABL1, STAT5, and AKT. Similarly, AML cell lines and primary patient samples with various genetic lesions showed inhibition of cell growth after treatment with OP449 alone or in combination with respective kinase inhibitors. Finally, OP449 reduced the tumor burden of mice xenografted with human leukemia cells. Conclusions We demonstrate a novel therapeutic paradigm of SET antagonism using OP449 in combination with tyrosine kinase inhibitors for the treatment of CML and AML. PMID:24436473

  7. Integration of a full co-op job experience (and direct job-placement) with an applied physics curriculum

    NASA Astrophysics Data System (ADS)

    Russell, Daniel

    2002-03-01

    Kettering University, formerly GMI Engineering & Management Institute, is a fully co-operational private institution offering bachelor's degrees in engineering, applied science, and management. The Applied Physics degree program was established in 1995 and our current freshman class has 11 students. The program takes 5 years to complete, during which time students alternate between 11 weeks in the classroom and 11 weeks at a co-op job at one of over 600 companies at over 800 locations around the world. All students, including applied physics majors, are required to complete a minimum of five co-op terms in order to graduate. In addition, they are required to complete a senior thesis of benefit to their company, a project which usually takes about six months (two co-op terms). In this talk we will describe the co-op program as it currently exists at Kettering and summarize the co-op experiences of our current applied physics students and our recent graduates. We will discuss how our curriculum has been designed to take advantage of and support the co-op experience. In addition we will discuss some of the challenges our students and faculty have encountered in the process of finding co-op sponsors.

  8. Mutational analysis of op18/stathmin-tubulin-interacting surfaces. Binding cooperativity controls tubulin GTP hydrolysis in the ternary complex.

    PubMed

    Segerman, B; Larsson, N; Holmfeldt, P; Gullberg, M

    2000-11-17

    Oncoprotein 18 (Op18) is a microtubule regulator that forms a ternary complex with two tubulin heterodimers. Dispersed regions of Op18 are involved in two-site cooperative binding and subsequent modulation of tubulin GTPase activity. Here we have analyzed specific determinants of Op18 that govern both stoichiometry and positive cooperativity in tubulin binding and consequent stimulatory and inhibitory effects on tubulin GTPase activity. The data revealed that the central and C-terminal regions of Op18 contain overlapping binding-motifs contacting both tubulin heterodimers, suggesting that these regions of Op18 are wedged into the previously noted 1-nm gap between the two longitudinally arranged tubulin heterodimers. Both the N- and C-terminal flanks adjacent to the central region are involved in stabilizing the ternary complex, but only the C-terminal flank does so by imposing positive binding cooperativity. Within the C-terminal flank, deletion of a 7-amino acid region attenuated positive binding cooperativity and resulted in a switch from stimulation to inhibition of tubulin GTP hydrolysis. This switch can be explained by attenuated binding cooperativity, because Op18 under these conditions may block longitudinal contact surfaces of single tubulins with consequent interference of tubulin-tubulin interaction-dependent GTP hydrolysis. Together, our results suggest that Op18 links two tubulin heterodimers via longitudinal contact surfaces to form a ternary GTPase productive complex.

  9. Influence of polychlorinated aromatic compounds on the biotransformation and toxicity of organophosphorus pesticides (OP) to the Daphnia magna

    SciTech Connect

    Tonkopii, V.; Zagrebin, A.; Sherstneva, L.

    1995-12-31

    The effect of different polychlorinated aromatics (DDT, Aroclor 1254, certain polychlorinated biphenyls and dibenzofurans) on the toxicity of OP (DDVP paraoxon, malaoxon) to Daphnia magna was studied. Pretreatment of daphnids with chlorinated compounds during 72 hours in nontoxic concentrations (1/5--1/20 CL{sub 50}) has been shown to reduce the toxicity of OP for hydrobionts. For study of influence of chlorinated compounds on biotransformation of OP the activity of enzymes which are hydrolyzing the OP was investigated in Daphnia`s homogenates or microsomes. The activity of carboxylesterase (tributyrinase, aliesterase) and arylesterase (phosphorylphosphatase) with usage as substrates accordingly {alpha}-naphthylacetate and paraoxon was measured. Besides that the activity of cholinesterase with application of propionylthiocholine as substrate was determined. After polychlorinated aromatic compounds treatment of daphnids activities of both aryl-and carboxylesterase increased markedly. It decreased the inhibition of Daphnia`s cholinesterase caused by incubation with OP in concentrations 0.5--1.0 CL{sub 50}. Thus the induction by chlorinate aromatics of OP metabolizing enzymes seems to play the important role in reduction of OP toxicity to Daphnia magna. Perhaps the aryl- and carboxylesterase of Daphnia can be used as biomarkers of pollution by polychlorinated aromatics in water.

  10. Development and initial application of δ18Op to understand phosphorus cycling in river, lake and groundwater ecosystems

    NASA Astrophysics Data System (ADS)

    Surridge, Ben; Gooddy, Daren; Newton, Rob; Moore, Oliver; Heaton, Timothy; Lapworth, Daniel; Davies, Ceri

    2014-05-01

    Variation in the stable isotope composition of oxygen within dissolved phosphate (δ18Op) represents a novel and potentially powerful environmental tracer. In freshwater, marine and terrestrial ecosystems, δ18Op can act as an inherent label for the sources of phosphorus and the extent to which phosphorus from different sources is metabolised. This paper focuses on the methodological development and initial application of δ18Op across a range of freshwater ecosystems. Initially, we report modifications to the analytical protocol for δ18Op that are designed to minimise incorporation of contaminant oxygen in the final silver phosphate precipitate prior to pyrolysis. This is critical given the range of possible sources of contaminant oxygen within freshwater matrices. Subsequently, we consider the potential utility of δ18Opthrough application of the technique within a range of freshwater ecosystems in England, UK. Firstly, we characterise δ18Opin river water and effluents from Sewage Treatment Works (STW), and examine the opportunity to use the δ18Op of STW effluents to trace the entry and downstream fate of phosphorus from these point sources in rivers. Secondly, we analyse δ18Opto gain insights into variations in the sources and biological cycling of phosphorus in a seasonally-stratified lake ecosystem. Thirdly, we characterise δ18Op in shallow and deep groundwater samples, considering whether δ18Op might provide evidence for variation in source and extent of metabolism for phosphorus in groundwater ecosystems. Taken together, these data extend the catalogue of δ18Op in freshwater ecosystems, and further the scope of δ18Op as a tool to better understand phosphorus biogeochemistry.

  11. System study of the carbon dioxide observational platform system (CO-OPS): Project overview

    NASA Technical Reports Server (NTRS)

    Stephens, J. Briscoe; Thompson, Wilbur E.

    1987-01-01

    The resulting options from a system study for a near-space, geo-stationary, observational monitoring platform system for use in the Department of Energy's (DOE) National Carbon Dioxide Observational Platform System (CO-OPS) on the greenhouse effect are discussed. CO-OPS is being designed to operate continuously for periods of up to 3 months in quasi-fixed position over most global regional targets of interest and could make horizon observations over a land-sea area of circular diameter up to about 600 to 800 statute miles. This affords the scientific and engineering community a low-cost means of operating their payloads for monitoring the regional parameters they deem relevant to their investigations of the carbon dioxide greenhouse effect at one-tenth the cost of most currently utilized comparable remote sensing techniques.

  12. PreOp endoscopic simulator: a PC-based immersive training system for bronchoscopy.

    PubMed

    Bro-Nielsen, M; Tasto, J L; Cunningham, R; Merril, G L

    1999-01-01

    The high cost of simulators that offer adequate realism for training has been a major challenge for the simulation community. The cost of the computers alone has been too high for most training institutions to afford. We have met this challenge by developing the PreOp Endoscopic Simulator, our second generation of low-cost medical simulators. The PreOp system integrates multimedia, 3D graphics simulation, and force feedback technology on a PC. This paper discusses the challenges of this project and the trade-offs and solutions that we developed to overcome them. We discuss our process of analyzing and prioritizing the medical tasks necessary to correctly perform flexible bronchoscopy. In addition, we illustrate how we blended together simulation and multimedia technology to ensure adequate immersion and training efficacy, while keeping the system cost to a minimum.

  13. Microscopic cluster model analysis of {sup 14}O+p elastic scattering

    SciTech Connect

    Baye, D.; Descouvemont, P.; Leo, F.

    2005-08-01

    The {sup 14}O+p elastic scattering is discussed in detail in a fully microscopic cluster model. The {sup 14}O cluster is described by a closed p shell for protons and a closed p3/2 subshell for neutrons in the translation-invariant harmonic-oscillator model. The exchange and spin-orbit parameters of the effective forces are tuned on the energy levels of the {sup 15}C mirror system. With the generator-coordinate and microscopic R-matrix methods, phase shifts and cross sections are calculated for the {sup 14}O+p elastic scattering. An excellent agreement is found with recent experimental data. A comparison is performed with phenomenological R-matrix fits. Resonances properties in {sup 15}F are discussed.

  14. SmeOP-TolCSm Efflux Pump Contributes to the Multidrug Resistance of Stenotrophomonas maltophilia

    PubMed Central

    Lin, Cheng-Wen; Huang, Yi-Wei; Hu, Rouh-Mei

    2014-01-01

    A five-gene cluster, tolCSm-pcm-smeRo-smeO-smeP, of Stenotrophomonas maltophilia was characterized. The presence of smeOP and smeRo-pcm-tolCSm operons was verified by reverse transcription (RT)-PCR. Both operons were negatively regulated by the TetR-type transcriptional regulator SmeRo, as demonstrated by quantitative RT-PCR and a promoter-fusion assay. SmeO and SmeP were associated with TolCSm (the TolC protein of S. maltophilia) for the assembly of a resistance-nodulation-cell-division (RND)-type pump. The compounds extruded by SmeOP-TolCSm mainly included nalidixic acid, doxycycline, amikacin, gentamicin, erythromycin, leucomycin, carbonyl cyanide 3-chlorophenylhydrazone, crystal violet, sodium dodecyl sulfate, and tetrachlorosalicylanilide. PMID:24395237

  15. A prototype expert system in OPS5 for data error detection

    NASA Technical Reports Server (NTRS)

    Rash, James

    1986-01-01

    A prototype expert system has been developed in the OPS5 language to perform error checking on data which spacecraft builders/users supply to the NASA Goddard Space Flight Center for processing on the Communications Link Analysis and Simulation System (CLASS) computer. This prototype expert system, called Trajectory Preprocessing System (TRAPS), contains 49 rules. In its operational phase, TRAPS will run in the Oak Ridge Production Language (ORPL) on the CLASS computer. ORPL, an implementation of OPS5 in MULTIFORTH on a desktop computer, is now being ported to SS-FORTH on the CLASS computer. This paper discusses the expert system problem domain, development approch, tools, results, and future plans stemming from the TRAPS project.

  16. Did the Olympics need more drugs? a doctor's reflection on providing medical care during Op OLYMPICS.

    PubMed

    Monteiro de Barros, James; Ross, D A

    2014-09-01

    This paper examines some of the medical problems arising from the successful deployment of Defence Medical Services personnel to Op OLYMPICS (mid-June 2012-September 2012). It does not aim to be all encompassing in its scope, but focuses on the most pressing issues affecting a junior military doctor's ability to work effectively under field conditions. This will entail a discussion about whether in a deployment such as Op OLYMPICS medical care should be based upon offering solely primary healthcare in medical centres or using Role 1 medical treatment facilities, which include primary healthcare and pre-hospital emergency care. The main recommendations arising from the deployment are: clinicians should deploy with a minimum of basic emergency drugs and equipment; a medical facility treating a large population at risk for a prolonged period should have a broad stock of medications available on site; and medical risk assessments must be performed on all Reservists during mobilisation.

  17. Air Traffic Management Technology Demonstration-1 Concept of Operations (ATD-1 ConOps)

    NASA Technical Reports Server (NTRS)

    Baxley, Brian T.; Johnson, William C.; Swenson, Harry; Robinson, John E.; Prevot, Thomas; Callantine, Todd; Scardina, John; Greene, Michael

    2012-01-01

    The operational goal of the ATD-1 ConOps is to enable aircraft, using their onboard FMS capabilities, to fly Optimized Profile Descents (OPDs) from cruise to the runway threshold at a high-density airport, at a high throughput rate, using primarily speed control to maintain in-trail separation and the arrival schedule. The three technologies in the ATD-1 ConOps achieve this by calculating a precise arrival schedule, using controller decision support tools to provide terminal controllers with speeds for aircraft to fly to meet times at a particular meter points, and onboard software providing flight crews with speeds for the aircraft to fly to achieve a particular spacing behind preceding aircraft.

  18. An expert system for automating security incident assessment using OPS5 in an Ada environment

    SciTech Connect

    Canales, T.W.; Smart, J.C.

    1988-01-29

    An expert system that automatically assesses security incidents is being developed at Lawrence Livermore National Laboratory. The expert system associates, classifies, and prioritizes monitored sensor events. The outcome of these processes is a dynamic representation of the state of Laboratory security in the form of security ''incidents''. A graphical representation of the incidents is integrated into a map-oriented console monitor that provides the operator with a comprehensive view of incidents and their locations. A prototype expert system has been developed using the OPS5 rule-based language. A large Ada-based program provides control of the map display system and interfaces to the various monitoring and access-control devices. In addition to the expert system operation, the issues and methods involved in integrating the OPS5-based incident-assessment system to the large Ada-based control program are discussed. 7 refs., 7 figs.

  19. Microscopic cluster model analysis of 14O+p elastic scattering

    NASA Astrophysics Data System (ADS)

    Baye, D.; Descouvemont, P.; Leo, F.

    2005-08-01

    The 14O+p elastic scattering is discussed in detail in a fully microscopic cluster model. The 14O cluster is described by a closed p shell for protons and a closed p3/2 subshell for neutrons in the translation-invariant harmonic-oscillator model. The exchange and spin-orbit parameters of the effective forces are tuned on the energy levels of the 15C mirror system. With the generator-coordinate and microscopic R-matrix methods, phase shifts and cross sections are calculated for the 14O+p elastic scattering. An excellent agreement is found with recent experimental data. A comparison is performed with phenomenological R-matrix fits. Resonances properties in 15F are discussed.

  20. An Automated Medical Information Management System (OpScan-MIMS) in a Clinical Setting

    PubMed Central

    Margolis, S.; Baker, T.G.; Ritchey, M.G.; Alterescu, S.; Friedman, C.

    1981-01-01

    This paper describes an automated medical information management system within a clinic setting. The system includes an optically scanned data entry system (OpScan), a generalized, interactive retrieval and storage software system(Medical Information Management System, MIMS) and the use of time-sharing. The system has the advantages of minimal hardware purchase and maintenance, rapid data entry and retrieval, user-created programs, no need for user knowledge of computer language or technology and is cost effective. The OpScan-MIMS system has been operational for approximately 16 months in a sexually transmitted disease clinic. The system's application to medical audit, quality assurance, clinic management and clinical training are demonstrated.

  1. Evaluation of the Immunogenicity of Diphtheria Toxoid Conjugated to Salmonella Typhimurium-Derived OPS in a Mouse Model: A Potential Vaccine Candidate Against Salmonellosis

    PubMed Central

    Amini, Vahid; Kazemian, Hossein; Yamchi, Jalil Kardan; Feyisa, Seifu Gizaw; Aslani, Saeed; Shavalipour, Aref; Houri, Hamidreza; Hoorijani, Mohammadneshvan; Halaji, Mehrdad; Heidari, Hamid

    2016-01-01

    Background Salmonella enterica serovar Typhimurium (S. Typhimurium) causes gastroenteritis in humans and paratyphoid disease in some animals. Given the emergence of antibiotic resistance, vaccines are more effective than chemotherapy in disease control. Objectives The aim of this experimental study was to evaluate the immunogenicity of diphtheria toxoid (DT) conjugated with S. Typhimurium -derived OPS (O side chain isolation) in mice to determine its potential as a vaccine candidate against salmonellosis. Materials and Methods Lipopolysaccharide (LPS) was extracted from the bacterial strain. After isolation of the O side chain of LPS, detoxification, and conjugation of the detoxified OPS samples with DT, pyrogenicity, toxicity, and sterility tests were performed. To vaccination, four groups of female Balb/c mice were used in an immunization test. Antibody responses were measured by the ELISA method. Challenging processes were performed to analyze the efficacy of the OPS-DT compound. Results Two weeks after the first vaccination dose, there was no significant difference in the antibody titers of the OPS and OPS-DT groups. However, after the second and third doses, the antibody titers of the OPS-DT group increased significantly compared with those of the control groups (P < 0.001). The induction of anti-OPS antibodies was as follows: OPS-DT>OPS. The most anti-OPS IgG antibody was IgG1. Challenging procedure showed successful protective characteristics in clinical examinations. Conclusions The results indicated that DT increased anti-OPS antibodies against the OPS-DT compound. The antibody response to OPS-DT was greater than that to OPS alone. We conclude that OPS-DT is an appropriate and acceptable vaccine candidate against salmonellosis. PMID:27660722

  2. Implementation of an OPS5 derivative on the Novix RISC processor

    SciTech Connect

    Williams, L.C.

    1988-01-01

    The recent popularity of rule-based programming and reduced instruction set computer (RISC) architectures has made the marriage of these two technologies an almost inevitable alternative for applying artificial intelligence (AI) techniques to real-time computing tasks. This paper presents an overview of the software development environment for a rule-based expert-system language based on OPS5 that was written specifically for the Novix NC4016 CPU.

  3. Treatment of Early Post-op Wound Infection after Internal Fixation

    DTIC Science & Technology

    2015-10-01

    Approximately 10%-40% of severe fractures fixed with internal fixation develop a deep wound infection during the healing process. Thus, the overall...stable while the bone heals . Approximately 10%-40% of severe fractures fixed with internal fixation develop a deep wound infection during the... healing process. Thus, the overall goals of this study are to (1) evaluate the effect of treatment of post-op wound infection in long bones after

  4. Mechanisms of Organophosphorus (OP) Injury: Sarin-Induced Hippocampal Gene Expression Changes and Pathway Perturbation

    DTIC Science & Technology

    2012-01-01

    inflammation and/or a role for prostanoid signaling in activity- dependent plasticity. Expression Ptgs2 can be induced by cytokines and mitogens, which...probably by ATM (ataxia telangiectasia mutated) or ATR (ataxia telangiectasia and Rad3 related). Per1 negatively regulates transactivation induced by...i AFRL-RH-FS-TR-2012-0008 Mechanisms of Organophosphorus (OP) Injury: Sarin- Induced Hippocampal Gene Expression Changes and Pathway

  5. Treatment of Early Post-Op Wound Infection after Internal Fixation

    DTIC Science & Technology

    2016-10-01

    Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Severe fractures are common in modern warfare with fractures ...being fixed via internal fixation of plates and screws to hold the fracture stable while the bone heals. Approximately 10%-40% of severe fractures ...effect of treatment of post-op wound infection in long bones after fracture fixation or joint fusion and either: (Group 1) operative debridement and

  6. Molecular spectroscopy from 5-12 μm using an OP-GaP OPO

    NASA Astrophysics Data System (ADS)

    Maidment, Luke; Schunemann, Peter G.; Reid, Derryck T.

    2017-02-01

    We report a femtosecond optical parametric oscillator (OPO) based on the new semiconductor gain material orientation patterned gallium phosphide (OP-GaP) and being the first example of a broadband OPO operating across the molecular fingerprint region. OP-GaP crystals with lengths of 1 mm and several patterning periods were diced, polished, and antireflection (AR) coated for near- to mid-infrared wavelengths. We configured a synchronously pumped OP-GaP OPO in a 101.2-MHz resonator with high reflectivity from 1.15-1.35 μm, pumped with 150-fs pulses from a 1040-nm femtosecond laser (Chromacity Spark). The coating of one spherical mirror was optimized for transmission at the pump wavelength of 1040 nm and for high reflectivity at the resonant signal wavelength in a range from 1.15-1.35 μm, while the other spherical mirror collimated the idler beam emerging from the OP-GaP crystal and was silver coated to provide high reflectivity for all idler wavelengths. This collimated idler beam was output-coupled from the cavity by transmission through a plane mirror coated with high transmission for the idler wavelengths (5-12 μm) and high reflectivity for the signal wavelengths (1.15-1.35 μm) on an infrared-transparent ZnSe substrate. Idler spectra centered from 5.4-11.8 μm and extending to 12.5 μm were collected. The maximum average power was 55 mW at 5.4 μm with 7.5 mW being recorded at 11.8 μm. Details of Fourier transform spectroscopy using water vapor and a polystyrene reference standard are presented.

  7. Op18/stathmin is involved in the resistance of taxol among different epithelial carcinoma cell lines.

    PubMed

    Lin, Xuechi; Liao, Ying; Xie, Juan; Liu, Shuangling; Su, Lijun; Zou, Haijiao

    2014-11-01

    Taxol is an effective chemotherapeutic agent against epithelial-derived carcinomas, and resistance of carcinoma cells to taxol has developed with the wide prescription of the drug. In this study, five different epithelial carcinoma cell lines were randomly employed to screen the resistant cell line to taxol, and to explore the probable mechanism of taxol-resistant development. Cells were grouped into the controls and the taxol treated. The treatment effects of five different epithelial carcinoma cell lines, including CNE1, Hep3B-2, MGC, MCF-7, and NCI-H1299, after being treated by taxol were analyzed through inspecting the ratios of cellular apoptosis, inhibition of cellular proliferation, the capability of cell colony formation and wound recovery, and the interference of cell motility and invasion, while western blot analysis and siRNA targeting Op18/stathmin were applied to explore the probable mechanism on the taxol resistance difference in these cells. Nonsmall cell lung cancer NCI-H1299 cells presented obvious taxol resistance, and the inhibition of cell motility and invasion was also the weakest in taxol-treated NCI-H1299 cells among these five cell lines. Microtubule dynamics analysis demonstrated that taxol treatment destroyed normal microtubule arrays and caused obvious microtubule collapse in CNE1, Hep3B-2, MGC, and MCF-7 rather than NCI-H1299, while the latter expressed high levels of microtubule-destabilizing protein Op18/stathmin. Inhibition of Op18/stathmin expression increased the sensitivity to taxol and promoted cellular apoptosis in NCI-H1299 cells. NCI-H1299 cells are evidently resistant to taxol-induced cellular apoptosis, inhibition of cellular proliferation and wound recovery, as well as cell migration and invasion interference, which are closely associated with the changes of microtubule dynamics. High expression of Op18/stathmin is perhaps a crucial determinant of taxol-resistant development in NCI-H1299 cells.

  8. NASA KSC/AFRL Reusable Booster System (RBS) Concept of Operations (ConOps)

    NASA Technical Reports Server (NTRS)

    Zeno, Dnany; Mosteller, Ted; McCleskey, Carey; Jhnson, Robert; Hopkins, Jason; Miller, Thomas

    2010-01-01

    This slide presentation reviews the study and findings of the study on the Concept of Operations (ConOps) for Reusable Booster System (RBS) centering on rapid turnaround and launch of a two-stage partially reusable payload delivery system (i.e., 8 hours between launches). The study was to develop rapid ground processing (aircraft like concepts) and identify areas for follow-on study, technology needs, and proof-of-concept demonstrations.

  9. OPS Test: Operational Test and Evaluation Support Tool. Volume 1 - Concepts and Capabilities

    DTIC Science & Technology

    2000-07-01

    practice tests. Test items are stored as Microsoft Word documents and can include a wide variety of embedded graphics, pictures, and charts. In...addition, test items may include associated multimedia clips that the test-taker can play as part of the test item. Feedback mechanisms to the test-taker...administration functions within OPS TEST include the ability to add and maintain test items , build and maintain master and specific tests, track test results

  10. Physical analysis and recalibration of MetOp HIRS using IASI for cloud studies

    NASA Astrophysics Data System (ADS)

    Chen, Ruiyue; Cao, Changyong

    2012-02-01

    The HIRS long-wave CO2 channels (702 cm-1, 716.5 cm-1, 731.7 cm-1, and 748.8 cm-1) have been used by scientists for estimating cloud height and amount. However, spectral and radiometric biases in these HIRS channels significantly affect the accuracy and consistency of the level-1b data used. This study utilizes the MetOp IASI measurements to calibrate the long-wave CO2 channels of the HIRS on the same satellite. The radiance bias characteristics are displayed for a sample MetOp orbit. Detailed analysis is performed in an attempt to find the causes of the bias. The analysis consists of three steps. First, a thermal-equilibrium analysis of blackbody using the HIRS window channel reveals the blackbody of MetOp HIRS has a 0.14 K bias. Then, the effective Spectral Response Function (SRF) corrections are estimated for the three long-wave CO2 channels by minimizing the orbital bias variation, which is -0.13 cm-1 for channel 4, 0.09 cm-1 for channel 5, and -0.15 cm-1 for channel 7. Channel brightness temperature dynamic range is found to be important for separating SRF versus nonlinearity effects. Finally, the nonlinearity effect is evaluated and the nonlinearity term is derived to reduce the orbital mean biases toward zero. The improved radiometric and spectral recalibration parameters are validated using 16 months of independent MetOp data, with very positive results, showing consistent performance. It is found that the HIRS biases relative IASI are generally within 0.1 K after the recalibration.

  11. Operational trace gas column observations from GOME-2 on MetOp

    NASA Astrophysics Data System (ADS)

    Valks, Pieter; Hao, Nan; Pinardi, Gaia; Hedelt, Pascal; Liu, Song; Van Roozendael, Michel; De Smedt, Isabelle; Theys, Nicolas; Koukouli, MariLiza; Balis, Dimitris

    2017-04-01

    This contribution focuses on the operational GOME-2 trace gas column products developed in the framework of EUMETSAT's Satellite Application Facility on Atmospheric Composition Monitoring (AC-SAF). We present an overview of the retrieval algorithms for ozone, OClO, NO2, SO2 and formaldehyde, and we show examples of various applications such as air quality and climate monitoring, using observations from the GOME-2 instruments on MetOp-A and MetOp-B. Total ozone and the minor trace gas columns from GOME-2 are retrieved with the latest version 4.8 of the GOME Data Processor (GDP), which uses an optimized Differential Optical Absorption Spectroscopy (DOAS) algorithm, with air mass factor conversions based on the LIDORT model. Improved total and tropospheric NO2 columns are retrieved in the visible wavelength region between 425 and 497 nm. SO2 emissions from volcanic and anthropogenic sources can be measured by GOME-2 using the UV wavelength region around 320 nm. For formaldehyde, an optimal DOAS fitting window around 335 nm has been determined for GOME-2. The GOME-2 trace gas columns have reached the operational EUMETSAT product status, and are available to the users in near real time (within two hours after sensing by GOME-2). The use of trace gas observations from the GOME-2 instruments on MetOp-A and MetOp-B for air quality purposed will be illustrated, e.g. for South-East Asia and Europe. Furthermore, comparisons of the GOME-2 satellite observations with ground-based measurements will be shown. Finally, the use of GOME-2 trace-gas column data in the Copernicus Atmosphere Monitoring Service (CAMS) will be presented.

  12. Evaluating hydrological influences on mid-latitude δ18Op in the Middle East

    NASA Astrophysics Data System (ADS)

    Reuter, Justin; Buenning, Nikolaus; Yoshimura, Kei

    2017-07-01

    The oxygen isotope ratio of precipitation (δ18Op) in the mid-latitudes varies in response to multiple climate influences imposing significant challenges to the interpretation of climate proxies such as the oxygen isotope ratio of lake and speleothem calcite (δ18Oc) that incorporates an isotopic finger print of precipitation. This challenge is particularly acute for pre-historic time periods when climate forcings differed significantly from modern and consequently, internal feedbacks altered the transport of moisture as well as the rate of fractionation that determine the isotopic composition of atmospheric moisture. Here we investigate how δ18Op from the mid-Holocene was influenced by internal feedbacks in the Holocene with an isotope-enabled climate model that simulates the atmospheric response to changing boundary conditions and different climatic forcing. We find that δ18Op during the Mid-Holocene was lower than present day consistent with published proxy records. However, this lower value cannot be simply explained by basic isotope drivers such as precipitation amount or seasonality. Rather, we find that the combination of changes in local surface temperature, precipitation amount, upstream isotopic composition of vapor as well as the season can quantitatively explain the isotopic differences between the mid-Holocene and present day.

  13. Cost-effective combination of contention resolution/avoidance schemes in bufferless slotted OPS networks

    NASA Astrophysics Data System (ADS)

    Rahbar, Akbar Ghaffar Pour

    2009-03-01

    Contention is a major problem for Optical Packed Switched (OPS) networks. Many studies have shown that to obtain a very small optical packet loss rate, a large number of specific contention resolution or contention avoidance hardware must be used. However, this may not be so cost-effective. Instead of using the same technique to achieve a very low packet loss rate, the idea of this paper is to use the combination of different contention avoidance and contention resolution schemes, but using a lower amount of each scheme, to reduce packet loss rate in slotted bufferless OPS networks. A number of cost-effective contention resolution and avoidance schemes are studied in order to decrease traffic loss and increase TCP throughput as a result. Designing a multi-fiber architecture that uses inexpensive shared-per-node wavelength converters and additional drop-ports can significantly reduce network-wide traffic loss. The lost traffic can also be retransmitted in the optical domain in order to have a loss-free OPS network. A cost model is also provided to obtain cost-effective combinations of fibers, wavelength converters and drop ports under a desirable TCP throughput and investment on network hardware. The effectiveness of the combined contention avoidance and resolution schemes are demonstrated under Internet traffic.

  14. The Trojan Horse Method as a tool to investigate low-energy resonances: the 18O(p, α)15N and 17O(p, α)14N cases

    NASA Astrophysics Data System (ADS)

    La Cognata, M.; Sergi, M. L.; Spitaleri, C.; Mukhamedzhanov, A.; Coc, A.; Cherubini, S.; Goldberg, V.; Gulino, M.; Hammache, F.; Irgaziev, B.; Kiss, G.; Lamia, L.; Pizzone, R. G.; Romano, S.; de Sereville, N.; Tribble, R.; Tumino, A.

    2010-08-01

    The 18O(p, α)15N and 17O(p, α)14N reactions are of primary importance in several as-trophysical scenarios, including nucleosynthesis inside Asymptotic Giant Branch stars and oxygen and nitrogen isotopic ratios in meteorite grains. They are also key reactions to understand exotic systems such as R-Coronae Borealis stars and novae. Thus, the measurement of their cross sections in the low energy region can be crucial to reduce the nuclear uncertainty on theoretical predictions, because the resonance parameters are poorly determined. The Trojan Horse Method, in its newly developed form particularly suited to investigate low-energy resonances, has been applied to the 2H(18O, α15N)n and 2H(17O, α14N)n reactions to deduce the 18O(p, α)15N and 17O(p, α)14N cross sections at low energies. Resonances in the 18O(p, α)15N and 17O(p, α)14N excitation functions have been studied and the resonance parameters deduced.

  15. The Trojan Horse Method as a tool to investigate low-energy resonances: the {sup 18}O(p, {alpha}){sup 15}N and {sup 17}O(p, {alpha}){sup 14}N cases

    SciTech Connect

    La Cognata, M.; Sergi, M. L.; Spitaleri, C.; Cherubini, S.; Gulino, M.; Kiss, G.; Lamia, L.; Pizzone, R. G.; Romano, S.; Mukhamedzhanov, A.; Goldberg, V.; Tribble, R.; Coc, A.; Hammache, F.; Sereville, N. de; Tumino, A.

    2010-08-12

    The {sup 18}O(p, {alpha}){sup 15}N and {sup 17}O(p, {alpha}){sup 14}N reactions are of primary importance in several as-trophysical scenarios, including nucleosynthesis inside Asymptotic Giant Branch stars and oxygen and nitrogen isotopic ratios in meteorite grains. They are also key reactions to understand exotic systems such as R-Coronae Borealis stars and novae. Thus, the measurement of their cross sections in the low energy region can be crucial to reduce the nuclear uncertainty on theoretical predictions, because the resonance parameters are poorly determined. The Trojan Horse Method, in its newly developed form particularly suited to investigate low-energy resonances, has been applied to the {sup 2}H({sup 18}O, {alpha}{sup 15}N)n and {sup 2}H({sup 17}O, {alpha}{sup 14}N)n reactions to deduce the {sup 18}O(p, {alpha}){sup 15}N and {sup 17}O(p, {alpha}){sup 14}N cross sections at low energies. Resonances in the {sup 18}O(p, {alpha}){sup 15}N and {sup 17}O(p, {alpha}){sup 14}N excitation functions have been studied and the resonance parameters deduced.

  16. Flight Dynamics Performances of the MetOp A Satellite during the First Months of Operations

    NASA Technical Reports Server (NTRS)

    Righetti, Pier Luigi; Meixner, Hilda; Sancho, Francisco; Damiano, Antimo; Lazaro, David

    2007-01-01

    The 19th of October 2006 at 16:28 UTC the first MetOp satellite (MetOp A) was successfully launched from the Baykonur cosmodrome by a Soyuz/Fregat launcher. After only three days of LEOP operations, performed by ESOC, the satellite was handed over to EUMETSAT, who is since then taking care of all satellite operations. MetOp A is the first European operational satellite for meteorology flying in a Low Earth Orbit (LEO), all previous satellites operated by EUMETSAT, belonging to the METEOSAT family, being located in the Geo-stationary orbit. To ensure safe operations for a LEO satellite accurate and continuous commanding from ground of the on-board AOCS is required. That makes the operational transition at the end of the LEOP quite challenging, as the continuity of the Flight Dynamics operations is to be maintained. That means that the main functions of the Flight Dynamics have to be fully validated on-flight during the LEOP, before taking over the operational responsibility on the spacecraft, and continuously monitored during the entire mission. Due to the nature of a meteorological operational mission, very stringent requirements in terms of overall service availability (99 % of the collected data), timeliness of processing of the observation data (3 hours after sensing) and accuracy of the geo-location of the meteorological products (1 km) are to be fulfilled. That translates in tight requirements imposed to the Flight Dynamics facility (FDF) in terms of accuracy, timeliness and availability of the generated orbit and clock solutions; a detailed monitoring of the quality of these products is thus mandatory. Besides, being the accuracy of the image geo-location strongly related with the pointing performance of the platform and with the on-board timing stability, monitoring from ground of the behaviour of the on-board sensors and clock is needed. This paper presents an overview of the Flight Dynamics operations performed during the different phases of the MetOp A

  17. One Stop Post Op cardiac surgery recovery--a proven success.

    PubMed

    Joyce, L; Pandolph, P

    2001-01-01

    The One Stop Post Op model for open heart surgery recovery is an innovative approach to post op care utilized in only a few facilities in the country. This model calls for an integration of acute ICU and step-down phases of care, thus changing the paradigm for nursing care of the open heart surgery patient. Typically, hospitals incur inefficiencies transferring the patient through multiple levels of care, thus resulting in a "disconnect" as new caregivers relearn the patient's care requirements and special needs. The construction of a "one stop" unit allows the patient to remain stationary while the service level changes to accommodate changing care needs. The cardiac "one stop" model is similar to the LDRP concept for obstetrical care. The One Stop Post Op patient rooms are designed to accommodate every level of patient acuity. All rooms meet the regulations for critical care room design, however this is where the aesthetic similarity ends. The patient environment looks more like hotel rooms rather than the traditional ICU setting. Cabinets designed to cover medical gases, in the room's private bathrooms and comfortable furnishings help to create a patient focused environment conducive to recovery. This model has been utilized by several facilities and has demonstrated clear clinical and economic advantages for patients, families, and health care providers. Implementing an open heart surgery (OHS) program presents the opportunity for several community based hospitals to challenge the way they have been providing patient care and establish an innovative approach to post surgery patient care. The One Stop Post Op cardiovascular recovery unit is designed to receive the OHS patient directly from the operating room and to be the "care unit" for the patient's entire stay. Patient flow, quality monitoring and caregiver acceptance in this unit requires new paradigms from the traditional two or three step post OHS care delivery process. The One Stop Post Op model focuses

  18. [Clinical consequences of using the new cardiovascular risk tables SCORE OP in patients aged over 65 years].

    PubMed

    Brotons, Carlos; Moral, Irene; Fernández, Diana; Cuixart, Lluis; Muñox, Alex; Soteras, Anna; Puig, Mireia; Joaniquet, Xavier; Casasa, Albert

    2016-11-04

    Estimating cardiovascular risk with SCORE is not recommended in persons over 65 years. SCORE investigators have recently published specific tables for older people (SCORE Older Persons [SCORE OP]). The aim of this study is to assess the impact of using SCORE OP tables on a Spanish population aged over 64 years, and compare it with the use of SCORE in patients aged 65-69 years. Cross-sectional study carried out in 2 urban primary health care centres. Individuals between 65 and 85 years old without diabetes or established cardiovascular diseases were included. Cardiovascular risk using SCORE and the new SCORE OP tables for low risk countries was calculated. Cardiovascular risk was estimated in 3,425 patients. Mean values of the original SCORE and SCORE OP were 4.08 and 3.83, respectively in the group of patients aged 65-69 years old (n=974, 22.44%) (P< .001). The percentage of patients at high or very high risk was 25.46% and 22.90% with the original SCORE and the SCORE OP, respectively (P<.001). Using the original SCORE, 16.43% of the total patients should potentially be treated with lipid lowering drugs, while using the SCORE OP, 13.45% of the patients aged 65-69 years should potentially be treated. Using SCORE OP in patients older than 69 years, 61.49% patients should potentially be treated with lipid lowering drugs. SCORE OP identifies fewer patients at high or very high risk than the original SCORE, therefore, its utilization would imply treating fewer patients of this age with lipid lowering drugs. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

  19. Upregulated Op18/stathmin activity causes chromosomal instability through a mechanism that evades the spindle assembly checkpoint

    SciTech Connect

    Holmfeldt, Per; Sellin, Mikael E.; Gullberg, Martin

    2010-07-15

    Op18/stathmin (Op18) is a microtubule-destabilizing protein that is phosphorylation-inactivated during mitosis and its normal function is to govern tubulin subunit partitioning during interphase. Human tumors frequently overexpress Op18 and a tumor-associated Q18{yields}E mutation has been identified that confers hyperactivity, destabilizes spindle microtubules, and causes mitotic aberrancies, polyploidization, and chromosome loss in K562 leukemia cells. Here we determined whether wild-type and mutant Op18 have the potential to cause chromosomal instability by some means other than interference with spindle assembly, and thereby bypassing the spindle assembly checkpoint. Our approach was based on Op18 derivatives with distinct temporal order of activity during mitosis, conferred either by differential phosphorylation inactivation or by anaphase-specific degradation through fusion with the destruction box of cyclin B1. We present evidence that excessive Op18 activity generates chromosomal instability through interference occurring subsequent to the metaphase-to-anaphase transition, which reduces the fidelity of chromosome segregation to spindle poles during anaphase. Similar to uncorrected merotelic attachment, this mechanism evades detection by the spindle assembly checkpoint and thus provides an additional route to chromosomal instability.

  20. Upregulated Op18/stathmin activity causes chromosomal instability through a mechanism that evades the spindle assembly checkpoint.

    PubMed

    Holmfeldt, Per; Sellin, Mikael E; Gullberg, Martin

    2010-07-15

    Op18/stathmin (Op18) is a microtubule-destabilizing protein that is phosphorylation-inactivated during mitosis and its normal function is to govern tubulin subunit partitioning during interphase. Human tumors frequently overexpress Op18 and a tumor-associated Q18-->E mutation has been identified that confers hyperactivity, destabilizes spindle microtubules, and causes mitotic aberrancies, polyploidization, and chromosome loss in K562 leukemia cells. Here we determined whether wild-type and mutant Op18 have the potential to cause chromosomal instability by some means other than interference with spindle assembly, and thereby bypassing the spindle assembly checkpoint. Our approach was based on Op18 derivatives with distinct temporal order of activity during mitosis, conferred either by differential phosphorylation inactivation or by anaphase-specific degradation through fusion with the destruction box of cyclin B1. We present evidence that excessive Op18 activity generates chromosomal instability through interference occurring subsequent to the metaphase-to-anaphase transition, which reduces the fidelity of chromosome segregation to spindle poles during anaphase. Similar to uncorrected merotelic attachment, this mechanism evades detection by the spindle assembly checkpoint and thus provides an additional route to chromosomal instability.

  1. Op. Cit.

    ERIC Educational Resources Information Center

    Zemsky, Robert, Ed.

    2001-01-01

    The fundamental concern of the roundtable on which this essay is based was the world of scholarship's ability to sustain and develop a system of scholarly communication that makes individual contributions to the knowledge base broadly accessible for judgment within and among the academic disciplines. The focus was on the disciplines that have…

  2. MELFI ops

    NASA Image and Video Library

    2015-05-18

    ISS043E207615 (05/18/2015) --- Expedition 43 Commander Terry Virts on the International Space Station works with experiment samples stored inside one of the station’s Minus Eighty-Degree Laboratory Freezer for ISS, or MELFI. These laboratory freezers are used to maintain experiment samples at ultra-cold temperatures throughout a mission.

  3. ATV ops

    NASA Image and Video Library

    2013-06-18

    ISS036-E-009219 (18 June 2013) --- Russian cosmonaut Pavel Vinogradov, Expedition 36 commander, performs cargo operations in the European Space Agency's Automated Transfer Vehicle-4 (ATV-4) "Albert Einstein" currently docked to the Zvezda Service Module of the International Space Station.

  4. ATV ops

    NASA Image and Video Library

    2013-06-18

    ISS036-E-009256 (18 June 2013) --- NASA astronauts Chris Cassidy and Karen Nyberg, both Expedition 36 flight engineers, perform cargo operations in the European Space Agency's Automated Transfer Vehicle-4 (ATV-4) "Albert Einstein" currently docked to the Zvezda Service Module of the International Space Station.

  5. ATV ops

    NASA Image and Video Library

    2013-06-18

    ISS036-E-009246 (18 June 2013) --- NASA astronaut Chris Cassidy, Expedition 36 flight engineer, takes inventory of cargo in the European Space Agency's Automated Transfer Vehicle-4 (ATV-4) "Albert Einstein" currently docked to the Zvezda Service Module of the International Space Station.

  6. ATV ops

    NASA Image and Video Library

    2013-06-18

    ISS036-E-009184 (18 June 2013) --- Russian cosmonaut Pavel Vinogradov, Expedition 36 commander, opens the hatch in the Zvezda Service Module transfer tunnel/ATV vestibule of the International Space Station after European Space Agency's Automated Transfer Vehicle-4 (ATV-4) "Albert Einstein" docked with the station.

  7. The RGB and AGB Star Nucleosynthesis in Light of the Recent 17O(p, α)14N and 18O(p, α)15N Reaction-rate Determinations

    NASA Astrophysics Data System (ADS)

    Palmerini, S.; Sergi, M. L.; La Cognata, M.; Lamia, L.; Pizzone, R. G.; Spitaleri, C.

    2013-02-01

    In recent years, the Trojan Horse Method (THM) has been used to investigate the low-energy cross sections of proton-induced reactions on A = 17 and A = 18 oxygen isotopes, overcoming extrapolation procedures and enhancement effects due to electron screening. In particular, the strengths of the 20 keV and 65 keV resonances in the 18O(p, α)15N and 17O(p, α)14N reactions, respectively, have been extracted, as well as the contribution of the tail of the broad 656 keV resonance in the 18O(p, α)15N reaction inside the Gamow window. The strength of the 65 keV resonance in the 17O(p, α)14N reaction, measured by means of the THM, has been used to renormalize the corresponding resonance strength in the 17O + p radiative capture channel. As a result, more accurate reaction rates for the 18O(p, α)15N, 17O(p, α)14N, and 17O(p, γ)18F processes have been deduced, devoid of systematic errors due to extrapolation or the electron screening effect. Such rates have been introduced into state-of-the-art red giant branch and asymptotic giant branch (AGB) models for proton-capture nucleosynthesis coupled with extra-mixing episodes. The predicted abundances have been compared with isotopic compositions provided by geochemical analysis of presolar grains. As a result, an improved agreement is found between the models and the isotopic mix of oxide grains of AGB origins, whose composition is the signature of low-temperature proton-capture nucleosynthesis. The low 14N/15N found in SiC grains cannot be explained by the revised nuclear reaction rates and remains a serious problem that has not been satisfactorily addressed.

  8. The object pattern separation (OPS) task: a behavioral paradigm derived from the object recognition task.

    PubMed

    van Hagen, B T J; van Goethem, N P; Lagatta, D C; Prickaerts, J

    2015-05-15

    The object recognition task (ORT) is widely used to measure object memory processes in rodents. Recently, the memory process known as pattern separation has received increasing attention, as impaired pattern separation can be one of the cognitive symptoms of multiple neurological and psychiatric disorders. Pattern separation is the formation of distinct representations out of similar inputs. In the search for an easily implemented task for rodents that can be used to measure pattern separation, we developed a task derived from the ORT and the object location task (OLT), which we called the object pattern separation (OPS) task. This task aims to measure spatial pattern separation per se, which utilizes memory processes centered in the DG and CA3 region of the hippocampus. Adult male C57BL/6 mice and adult male Wistar rats were used to validate different object locations which can be used to measure spatial pattern separation. Furthermore, different inter-trial time intervals were tested with the most optimal object location, to further evaluate pattern separation-related memory in mice. We found that specific object locations show gradual effects, which is indicative of pattern separation, and that the OPS task allows the detection of spatial pattern separation bi-directionally at intermediate spatial separations. Thus, object locations and time intervals can be specifically adjusted as needed, in order to investigate an expected improvement or impairment. We conclude that the current spatial OPS task can be best described as a specific version of the ORT, which can be used to investigate pattern separation processes. Copyright © 2014 Elsevier B.V. All rights reserved.

  9. Numerical modeling of open pit (OP) to underground (UG) transition in coal mining

    NASA Astrophysics Data System (ADS)

    Nguyen, Phu Minh Vuong; Niedbalski, Zbigniew

    2016-09-01

    The primary objective of the present paper is an attempt at evaluating the influence of sub-level caving operations on the slope stability of a still-functioning open pit coal mine in Vietnam. Initially, various methods of predicting the impact of underground mining on surface stability are discussed. Those theoretical considerations were later utilized in the process of constructing a Flac-2D-software-based numerical model for calculating the influence of underground operation on the deformation and possible loss of stability of an open pit slope. The numerical analysis proved that the values of open pit slope displacements were affected mainly by underground exploitation depth, direction of operation (i.e., from one slope to the other) and the distance from the slope plane. Real geomechanical strata parameters from the Vietnamese coal basin of Cam Pha were used in the modeling process. The paper is, therefore, a critical review of the hitherto proposed methods of predicting the impact of underground operation (UG) on open pit mining (OP), illustrated with selected examples of case studies on OP-UG interaction, followed by an original experiment based on numerical modeling method. This is first such study for the genuine conditions of the coal mining in Vietnam. The obtained results, however, should not be generalized due to a highly specific character of the analyzed phenomenon of mining-induced surface deformation. The practical implications of the study may occur extremely useful in the case of an UG-OP transition. Such a transition is often necessary for both technical and economical reasons, as in some coal basins open pit operations at greater depths occur unfeasible, which calls for a proper selection of parameters for a planned underground operation.

  10. Effect of intrapartum oropharyngeal (IP-OP) suction on meconium aspiration syndrome (MAS) in developing country: A RCT.

    PubMed

    Nangia, Sushma; Pal, Mansi M; Saili, Arvind; Gupta, Usha

    2015-12-01

    Evidence about IP-OP suction and selective tracheal intubation in meconium stained neonates is from developed countries. Little information is available about their role in developing countries with high incidence of meconium staining and MAS. This randomized trial was planned to evaluate the effectiveness of IP-OP suction in meconium stained term neonates on prevention of MAS and reduction of its severity. Out of 540 meconium stained full term, cephalic presentation, singleton neonates without major congenital malformations born from June'08 to January'09, 31 were excluded and 509 randomized. In the intervention group IP-OP suction was done at the time of delivery of head using a 10 Fr suction catheter with a negative pressure of 100 mmHg. No IP-OP suction was performed in control group. All neonates with MSAF were assessed as vigorous or non-vigorous after birth and provided care as per NRP guidelines 2005. Two hundred and fifty three neonates were randomized to IP-OP suction and 256 to no IP-OP suction. Eighty-two neonates (16%) developed MAS, the primary outcome parameter, with 40 infants in the intervention group (15.8%) and 42 (16.4%) in the non-intervention group (RR 0.86, 95% CI 0.60-1.54). Incidence of severe MAS was comparable (3.55% vs. 2.34%) (P value=0.40). Other variables like requirement of oxygen >48 h (9.8% vs. 10.5%) and mortality (2.7% vs. 1.7%) were also comparable. IP-OP suctioning did not reduce the incidence or severity of MAS even in a setting of high incidence of MAS in a developing country. The mortality in two groups was comparable. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  11. NASA's Participation in Joint SatOPS Compatibility Efforts 2009-2010

    NASA Technical Reports Server (NTRS)

    Smith, Danford

    2010-01-01

    Many U.S. government organizations build or fly space systems: a) NASA, NOAA, Navy, Air Force, NRO, ORS. Others? b) Through the Joint SatOps Compatibility Committee (JSCC) we have increased the grass-roots interaction between many of these organizations. c) We all deal with many of the same challenges: More rapid deployments, lower budgets; Advancing technologies - frameworks, clouds, virtualization; Evolving concepts - automation, situational awareness, enterprise mngt. Standardization - formal or by common use. There is an inherently governmental role in creating the business case for contractors and commercial product vendors to move in directions beneficial to multiple government space organizations.

  12. Excitation Function for the 74Se(18O,p3n) Reaction

    SciTech Connect

    Gates, Jacklyn; Dragojevic, Irena; Dvorak, Jan; Ellison, Paul; Gregorich, Kenneth; Stavsetra, Liv; Nitsche, Heino

    2009-02-02

    The 74Se(18O,p3n)88gNb excitation function was measured and a maximum cross section of 495+-5 mb was observed at and 18O energy of 74.0 MeV. Experimental cross sections were compared to theoretical calculations using the computer code ALICE-91 and the values were found to be in good agreement. The half life of 88gNb was determined to be around 14.56+-0.11 min.

  13. Taking climate change seriously: An analysis of op-ed articles in Spanish press.

    PubMed

    Domínguez, Martí; Lafita, Íngrid; Mateu, Anna

    2017-10-01

    In this article, we study the evolution of opinion genres regarding climate change in three Spanish newspapers ( El País, El Mundo, and ABC). Analyzing the op-ed articles in these newspapers, we observe a significant change in the evolution of opinion. While denialism was very present in conservative press in 2007, 7 years later it is almost absent from El Mundo, and its presence in ABC is much lower and inactive: this shows that scientific consensus has prevailed over time and Spanish denialism has weakened, exclusively supported by political arguments by the most conservative parties.

  14. A Coupled Programme of Aerosol Research Within the OP3 and ACES Projects

    NASA Astrophysics Data System (ADS)

    McFiggans, G.; Aces Aerosol Teams, P A

    2008-12-01

    The oxidation of organic compounds in the troposphere plays a central role in the generation of ozone, and leads to the formation of secondary organic aerosol (SOA) and other secondary pollutants. Approximately 90% of organic material emitted globally is estimated to originate from biogenic sources, with almost half of all reactive biogenic volatile organic compounds (BVOC) being emitted from tropical and sub-tropical forests. It is becoming increasingly clear from observational studies that biogenic SOA (BSOA) is the dominant source of aerosol organic carbon concentrations in remote environments. This provides part of the motivation for the OP3 project. Ground-based aerosol measurements at the Global Atmosphere Watch (GAW) site in Danum Valley Conservation Area in OP3 were provided by a suite of instrumentation for full composition and physical property characterisation (size distribution, hygroscopicity and CCN activation). To further enhance our understanding of aerosol processes in the Borneo rainforest, additional capability was assembled within the UK NERC funded "Aerosol Coupling in the Earth System" (ACES) programme. Field component enhancements to the OP3 aerosol payload by ACES included a deployment of aerosol and precursor flux measurements within the forest canopy to characterise primary bioaerosol sources and in-canopy chemistry leading to formation of secondary aerosol components. In addition, measurements of VOCs and aerosol composition were made above an oil palm plantation to assess the impact of land-use change on aerosol processes. ACES is a coupled programme of field, chamber, mechanism development and modelling investigations aiming to reduce uncertainties in our fundamental understanding of BSOA formation and the subsequent impact on atmospheric composition. In addition to summarising aerosol field measurements within ACES / OP3, we will present an overview of the status of the ACES chamber and modelling results with the overall aim to: i

  15. Process characteristics and design methods for a 300 deg quad OP amp

    NASA Technical Reports Server (NTRS)

    Beasom, J. D.; Patterson, R. B., III

    1981-01-01

    The results of process characterization, circuit design, and reliability studies for the development of a quad OP amplifier intended for use up to 300 C are presented. A dielectrically isolated complementary vertical bipolar process was chosen to fabricate the amplifier in order to eliminate isolation leakage and the possibility of latch up. Characterization of NPN and PNP junctions showed them to be suitable for use up to 300 C. Interconnect reliability was predicted to be greater than four years mean time between failure. Parasitic MOS formation was eliminated by isolation of each device.

  16. "Keeping our mission, changing our system": translation and organizational change in natural foods co-ops.

    PubMed

    Haedicke, Michael A

    2012-01-01

    Institutional theory has played a central role in the study of organizations for over half a century, but it often overlooks the actions of the people who bring organizations to life. This article advances an inhabited approach to institutional analysis that foregrounds the creativity of organizational members. It argues that people use local cultures to translate and respond to institutional pressures. The article analyzes qualitative data from countercultural co-op stores that have been pushed to conform to mainstream forms of business organization by a competitive market and demonstrates that translation explains why outcomes that institutional theory would not predict have come to pass.

  17. A novel all-optical label processing for OPS networks based on multiple OOC sequences from multiple-groups OOC

    NASA Astrophysics Data System (ADS)

    Qiu, Kun; Zhang, Chongfu; Ling, Yun; Wang, Yibo

    2007-11-01

    This paper proposes an all-optical label processing scheme using multiple optical orthogonal codes sequences (MOOCS) for optical packet switching (OPS) (MOOCS-OPS) networks, for the first time to the best of our knowledge. In this scheme, the multiple optical orthogonal codes (MOOC) from multiple-groups optical orthogonal codes (MGOOC) are permuted and combined to obtain the MOOCS for the optical labels, which are used to effectively enlarge the capacity of available optical codes for optical labels. The optical label processing (OLP) schemes are reviewed and analyzed, the principles of MOOCS-based optical labels for OPS networks are given, and analyzed, then the MOOCS-OPS topology and the key realization units of the MOOCS-based optical label packets are studied in detail, respectively. The performances of this novel all-optical label processing technology are analyzed, the corresponding simulation is performed. These analysis and results show that the proposed scheme can overcome the lack of available optical orthogonal codes (OOC)-based optical labels due to the limited number of single OOC for optical label with the short code length, and indicate that the MOOCS-OPS scheme is feasible.

  18. Comparison among Op-site, polyvinyl chloride film and tulle gauze in the treatment of skin graft donor sitet.

    PubMed

    Poonyakariyagorn, Theerapong; Sirimaharaj, Wimon; Pinchai, Opart; Angspatt, Apichai

    2002-04-01

    A prospective analytic study was performed at the Division of Plastic and Reconstructive Surgery, Department of Surgery, King Chulalongkorn Memorial University Hospital and the Department of Surgery, Chiang Mai University Hospital to compare among Polyvinyl chloride film (PVC film), Op-site and tulle gauze in the treatment of skin graft donor site. From October 1998 to January 2000, 81 donor sites in the same number of patients were treated by three different methods; tulle gauze (26 patients), Op-site (27 patients) and PVC film (28 patients). Each wound was followed until it was completely healed and visual analogue scale was used for pain evaluation. Donor site dressed with PVC film had a healing time of 10.44 days which was not different from Op-site (10.54 days) but significantly faster (p<0.001) than tulle gauze (17.84 days). Pain as measured with visual analogue scale in the group of PVC film (1.48) was not different from Op-site (1.34) but significantly less than (p<0.001) tulle gauze (5.45). There was no difference in the rate of infection between each group. In conclusion, the authors found no difference between Op-site and PVC film in healing time and pain. Both of them were better than tulle gauze. The results demonstrate the usefulness of PVC film as a donor site dressing as it promises relatively rapid healing, less pain and is inexpensive.

  19. In ovo exposure to o,p -DDE affects sexual development but not sexual differentiation in Japanese medaka (Oryzias latipes).

    USGS Publications Warehouse

    Papoulias, D.M.; Villalobos, Sergio A.; Meadows, J.; Noltie, Douglas B.; Giesy, J.P.; Tillitt, D.E.

    2003-01-01

    Despite being banned in many countries, dichlorodiphenyltrichloroethane (DDT) and its metabolites dichlorodiphenyldichloroethylene (DDE) and dichlorodiphenyldichloroethane (DDD) continue to be found in fish tissues at concentrations of concern. Like o,p -DDT, o,p -DDE is estrogenic and is believed to exert its effects through binding to the estrogen receptor. The limited toxicologic data for o,p -DDE suggest that it decreases fecundity and fertility of fishes. We conducted an egg injection study using the d-rR strain of medaka and environmentally relevant concentrations of o,p -DDE to examine its effects on sexual differentiation and development. The gonads of exposed fish showed no evidence of sex reversal or intersex. However, other gonad abnormalities occurred in exposed individuals. Females exhibited few vitellogenic oocytes and increased atresia. Male testes appeared morphologically normal but were very small. Gonadosomatic index values for both sexes were lower for exposed fish. Our observations of abnormal female and very small male gonads after in ovo o,p -DDE exposure may be indicative of effects on early endocrine processes important for normal ovarian and testicular development.

  20. Organic waste composting at the Semple Street Co-op. Final report

    SciTech Connect

    Not Available

    1985-01-01

    Accomplishments in the development of a vermiculture room are described. The purpose of the project is to develop an earthworm composting system for processing organic (food) wastes. The composting room in its completed form consists of an insulated room with exterior access, a utility tub, a grinder and racks to accommodate earthworm pans. As of now, the earthworms are being fed regularly, and are increasing in numbers. The responsibility of finding and scheduling volunteers for feeding has come under the wing of the regular co-op volunteer coordinator and has been institutionalized into the co-op's operations. The present population of earthworms is approximately 10,000, a sufficient number to process one day's organic waste, one day a week. It will require no more than 60,000 earthworms to compost all of the organic waste at the current level of waste generation. At a distribution of 1000 to 2000 worms per pan, it is estimated that the project will operate in its full capacity with between 30 and 60 pans.

  1. Synergistic effect of mixed neutron and gamma irradiation in bipolar operational amplifier OP07

    NASA Astrophysics Data System (ADS)

    Yan, Liu; Wei, Chen; Shanchao, Yang; Xiaoming, Jin; Chaohui, He

    2016-09-01

    This paper presents the synergistic effects in bipolar operational amplifier OP07. The radiation effects are studied by neutron beam, gamma ray, and mixed neutron/gamma ray environments. The characterateristics of the synergistic effects are studied through comparison of different experiment results. The results show that the bipolar operational amplifier OP07 exhibited significant synergistic effects in the mixed neutron and gamma irradiation. The bipolar transistor is identified as the most radiation sensitive unit of the operational amplifier. In this paper, a series of simulations are performed on bipolar transistors in different radiation environments. In the theoretical simulation, the geometric model and calculations based on the Medici toolkit are built to study the radiation effects in bipolar components. The effect of mixed neutron and gamma irradiation is simulated based on the understanding of the underlying mechanisms of radiation effects in bipolar transistors. The simulated results agree well with the experimental data. The results of the experiments and simulation indicate that the radiation effects in the bipolar devices subjected to mixed neutron and gamma environments is not a simple combination of total ionizing dose (TID) effects and displacement damage. The data suggests that the TID effect could enhance the displacement damage. The synergistic effect should not be neglected in complex radiation environments.

  2. OZONE PRODUCTION IN THE PHILADELPHIA URBAN AREA DURING NE-OPS 99.

    SciTech Connect

    KLEINMAN,L.I.; DAUM,P.H.; BRECHTEL,F.; LEE,Y.N.; NUNNERMACKER,L.J.; SPRINGSTON,S.R.; WEINSTEIN-LLOYD,J.

    2001-10-01

    As part of the 1999 NARSTO Northeast Oxidant and Particulate Study (NE-OPS) field campaign, the DOE G-1 aircraft sampled trace gases and aerosols in and around the Philadelphia metropolitan area. Twenty research flights were conducted between July 25 and August 11. The overall goals of these flights were to obtain a mechanistic understanding of O{sub 3} production; to characterize the spatial and temporal behavior of photo-oxidants and aerosols; and to study the evolution of aerosol size distributions, including the process of new particle formation. Within the NE-OPS program, other groups provided additional trace gas, aerosol, and meteorological observations using aircraft, balloon, remote sensing, and surface based instruments (Phillbrick et al., 2000). In this article we provide an overview of the G-1 observations related to O{sub 3} production, focusing on the vertical distribution of pollutants. Ozone production rates are calculated using a box model that is constrained by observed trace gas concentrations. Highest O{sub 3} concentrations were observed on July 31, which we present as a case study. On that day, O{sub 3} concentrations above the 1-hour 120 ppb standard were observed downwind of Philadelphia and also in the plume of a single industrial facility located on the Delaware River south of the city.

  3. Crotonis Fructus and Its Constituent, Croton Oil, Stimulate Lipolysis in OP9 Adipocytes

    PubMed Central

    Kim, Mi-Seong; Kim, Ha-Rim; So, Hong-Seob; Lee, Young-Rae; Moon, Hyoung-Chul; Ryu, Do-Gon; Yang, Sei-Hoon; Lee, Guem-San; Song, Je-Ho; Kwon, Kang-Beom

    2014-01-01

    Introduction. Crotonis fructus (CF) is the mature fruit of Croton tiglium L. and has been used for the treatment of gastrointestinal disturbance in Asia. It is well known that the main component of CF is croton oil (CO). The present study is to investigate the effects of CF extracts (CFE) and CO on lipolysis in OP9 adipocytes. Methods. Glycerol release to the culture supernatants was used as a marker of adipocyte lipolysis. Results. Treatment with various concentrations of CFE and CO stimulates glycerol release in a dose-dependent manner. The increase in glycerol release by CFE is more potent than isoproterenol, which is a β-adrenergic agonist as a positive control in our system. The increased lipolysis by CFE and CO was accompanied by an increase of phosphorylated hormone sensitive lipase (pHSL) but not nonphosphorylated HSL protein and mRNA. Pretreatment with H89, which is a protein kinase A inhibitor, significantly abolished the CFE- and CO-induced glycerol release in OP9 adipocytes. These results suggest that CFE and CO may be a candidate for the development of a lipolysis-stimulating agent in adipocytes. PMID:25435891

  4. Crotonis Fructus and Its Constituent, Croton Oil, Stimulate Lipolysis in OP9 Adipocytes.

    PubMed

    Kim, Mi-Seong; Kim, Ha-Rim; So, Hong-Seob; Lee, Young-Rae; Moon, Hyoung-Chul; Ryu, Do-Gon; Yang, Sei-Hoon; Lee, Guem-San; Song, Je-Ho; Kwon, Kang-Beom

    2014-01-01

    Introduction. Crotonis fructus (CF) is the mature fruit of Croton tiglium L. and has been used for the treatment of gastrointestinal disturbance in Asia. It is well known that the main component of CF is croton oil (CO). The present study is to investigate the effects of CF extracts (CFE) and CO on lipolysis in OP9 adipocytes. Methods. Glycerol release to the culture supernatants was used as a marker of adipocyte lipolysis. Results. Treatment with various concentrations of CFE and CO stimulates glycerol release in a dose-dependent manner. The increase in glycerol release by CFE is more potent than isoproterenol, which is a β-adrenergic agonist as a positive control in our system. The increased lipolysis by CFE and CO was accompanied by an increase of phosphorylated hormone sensitive lipase (pHSL) but not nonphosphorylated HSL protein and mRNA. Pretreatment with H89, which is a protein kinase A inhibitor, significantly abolished the CFE- and CO-induced glycerol release in OP9 adipocytes. These results suggest that CFE and CO may be a candidate for the development of a lipolysis-stimulating agent in adipocytes.

  5. Virtual microscopy in medical research: Open European Nephrology Science Center (OpEN.SC)

    NASA Astrophysics Data System (ADS)

    Schrader, Thomas; Beil, Michael; Schmidt, Danilo; Dietel, Manfred; Lindemann, Gabriela

    2007-03-01

    The amount and heterogeneity of data in biomedical research, notably in transnational research, requires new methods for the collection, presentation and analysis of information. Important data from laboratory experiments as well as patient trials are available as images. Thus, the integration and processing of image data represent a crucial component of information systems in biomedical research. The Charité Medical School in Berlin has established a new information service center for kidney diseases and transplantation (Open European Nephrology Science Centre - OpEN.SC) together with the German Research Agency (DFG). The aims of this project are (i) to improve the availability of raw data, (ii) to establish an infrastructure for clinical trials, (iii) to monitor the occurrence of rare disease patterns and (iv) to establish a quality assurance system. Major diagnostic procedures in medicine are based on the processing and analysis of image data. In diagnostic pathology, the availability of automated slide scanners provide the opportunity to digitize entire microscopic slides. The processing, presentation and analysis of these image data are called virtual microscopy. The integration of this new technology into the OpEN.SC system and the link to other heterogeneous data of individual patients represent a major technological challenge. Thus, new ways in communication between clinical and scientific partners have to be established and will be promoted by the project. The technological basis of the repository are web services for a scalable and adaptable system. HL7 and DICOM are considered the main medical standards of communication.

  6. La fasciite nécrosante post opératoire: une complication rare et mortelle

    PubMed Central

    Ghezala, Hassen Ben; Feriani, Najla

    2016-01-01

    Les complications pariétales post opératoire peuvent être exceptionnellement majeures et graves menaçant le pronostic vital. La fasciite nécrosante est une infection rare de la peau et des tissus sous-cutanés profonds, se propageant le long des fascias et du tissu adipeux. Elle est surtout causée par le streptocoque du groupe A Streptococcus pyogènes mais également par d'autres bactéries telles que Vibrio vulnificus, clostridium perfringens ou Bacteroides fragilis. La fasciite nécrosante est une véritable urgence médicochirurgicale. Nous rapportons dans ce travail une observation très rare d'une gangrène pariétale abdominale survenant chez une patiente de 75 ans au cinquième jour post-opératoire d'un kyste de l'ovaire. L’évolution était marquée par l'installation d'un état de choc septique réfractaire rapidement fatal à J3 de la prise en charge. PMID:27279950

  7. Assessing Protection Against OP Pesticides and Nerve Agents Provided by Wild-Type HuPON1 Purified from Trichoplusia ni Larvae or Induced via Adenoviral Infection

    DTIC Science & Technology

    2013-01-01

    organophosphorus (OP) pesticides and nerve agents. We assessed the potential of this enzyme to protect against OP poison - ing using two different paradigms...6,10–13]. PON1 is believed to play an important role in determining the resistance or susceptibility to OP pesticide poisoning , in that PON1 knockout...type nerve agent are inadequate to protect against poisoning by these compounds [17,18]. In contrast, injection of exogenous wild-type HuPON1 has

  8. Temperature dependence of o-Ps annihilation lifetime in non-uniform cylindrical pores in comparison with ETE model

    NASA Astrophysics Data System (ADS)

    Khaghani, Morteza; Mehmandoost-Khajeh-Dad, Ali Akbar

    2017-04-01

    Ortho-positronium (o-Ps) annihilation lifetime was calculated in non-uniform cylinder-shaped pores by solving Schrodinger equation using a well-known multi-physics program called COMSOL. The o-Ps annihilation lifetime variation in terms of temperature was calculated on the basis of ETE model via a numerical method. The COMSOL simulations indicate that as long as the pore is uniform cylinder-shaped, the results agree with those of two-dimensional ETE model, whereas deformations in the cylinder shape (indentation or protrusion) change the temperature behavior of ETE model and, thereby, higher values are predicted for o-Ps lifetime in the pore at lower temperatures. The geometry of the non-uniform cylinder-shaped pores, which is accompanied by empirical evidence, can be used for the analysis of empirical results obtained from positron lifetime spectroscopy in different temperatures.

  9. Potential spin-offs of the carbon dioxide observational platform system (CO-OPS) for remote sensing opportunities

    NASA Technical Reports Server (NTRS)

    Stephens, J. B.

    1985-01-01

    Alternate remote sensing techniques that could utilize the slight losses of energy from the microwave beam which powers the NASA/MSFC Carbon Dioxide Observational Platform System (CO-OPS) to achieve the objectives of the U.S. Department of Energy (DOE) Carbon Dioxide Research Program's regional observational data requirements, ODRs, are addressed heuristically. The opportunity for regional remote sensing of the carbon dioxide and water vapor constituents in the atmosphere are discussed as a potential spin off of the CO-OPS. The CO-OPS is envisioned as a high altitude (approx. 25 km) observational platform system powered by microwave energy for regional observational use by the DOE in their Carbon Dioxide Research Program.

  10. Phylogeny and physiology of candidate phylum ‘Atribacteria' (OP9/JS1) inferred from cultivation-independent genomics

    PubMed Central

    Nobu, Masaru K; Dodsworth, Jeremy A; Murugapiran, Senthil K; Rinke, Christian; Gies, Esther A; Webster, Gordon; Schwientek, Patrick; Kille, Peter; Parkes, R John; Sass, Henrik; Jørgensen, Bo B; Weightman, Andrew J; Liu, Wen-Tso; Hallam, Steven J; Tsiamis, George; Woyke, Tanja; Hedlund, Brian P

    2016-01-01

    The ‘Atribacteria' is a candidate phylum in the Bacteria recently proposed to include members of the OP9 and JS1 lineages. OP9 and JS1 are globally distributed, and in some cases abundant, in anaerobic marine sediments, geothermal environments, anaerobic digesters and reactors and petroleum reservoirs. However, the monophyly of OP9 and JS1 has been questioned and their physiology and ecology remain largely enigmatic due to a lack of cultivated representatives. Here cultivation-independent genomic approaches were used to provide a first comprehensive view of the phylogeny, conserved genomic features and metabolic potential of members of this ubiquitous candidate phylum. Previously available and heretofore unpublished OP9 and JS1 single-cell genomic data sets were used as recruitment platforms for the reconstruction of atribacterial metagenome bins from a terephthalate-degrading reactor biofilm and from the monimolimnion of meromictic Sakinaw Lake. The single-cell genomes and metagenome bins together comprise six species- to genus-level groups that represent most major lineages within OP9 and JS1. Phylogenomic analyses of these combined data sets confirmed the monophyly of the ‘Atribacteria' inclusive of OP9 and JS1. Additional conserved features within the ‘Atribacteria' were identified, including a gene cluster encoding putative bacterial microcompartments that may be involved in aldehyde and sugar metabolism, energy conservation and carbon storage. Comparative analysis of the metabolic potential inferred from these data sets revealed that members of the ‘Atribacteria' are likely to be heterotrophic anaerobes that lack respiratory capacity, with some lineages predicted to specialize in either primary fermentation of carbohydrates or secondary fermentation of organic acids, such as propionate. PMID:26090992

  11. Phylogeny and physiology of candidate phylum 'Atribacteria' (OP9/JS1) inferred from cultivation-independent genomics.

    PubMed

    Nobu, Masaru K; Dodsworth, Jeremy A; Murugapiran, Senthil K; Rinke, Christian; Gies, Esther A; Webster, Gordon; Schwientek, Patrick; Kille, Peter; Parkes, R John; Sass, Henrik; Jørgensen, Bo B; Weightman, Andrew J; Liu, Wen-Tso; Hallam, Steven J; Tsiamis, George; Woyke, Tanja; Hedlund, Brian P

    2016-02-01

    The 'Atribacteria' is a candidate phylum in the Bacteria recently proposed to include members of the OP9 and JS1 lineages. OP9 and JS1 are globally distributed, and in some cases abundant, in anaerobic marine sediments, geothermal environments, anaerobic digesters and reactors and petroleum reservoirs. However, the monophyly of OP9 and JS1 has been questioned and their physiology and ecology remain largely enigmatic due to a lack of cultivated representatives. Here cultivation-independent genomic approaches were used to provide a first comprehensive view of the phylogeny, conserved genomic features and metabolic potential of members of this ubiquitous candidate phylum. Previously available and heretofore unpublished OP9 and JS1 single-cell genomic data sets were used as recruitment platforms for the reconstruction of atribacterial metagenome bins from a terephthalate-degrading reactor biofilm and from the monimolimnion of meromictic Sakinaw Lake. The single-cell genomes and metagenome bins together comprise six species- to genus-level groups that represent most major lineages within OP9 and JS1. Phylogenomic analyses of these combined data sets confirmed the monophyly of the 'Atribacteria' inclusive of OP9 and JS1. Additional conserved features within the 'Atribacteria' were identified, including a gene cluster encoding putative bacterial microcompartments that may be involved in aldehyde and sugar metabolism, energy conservation and carbon storage. Comparative analysis of the metabolic potential inferred from these data sets revealed that members of the 'Atribacteria' are likely to be heterotrophic anaerobes that lack respiratory capacity, with some lineages predicted to specialize in either primary fermentation of carbohydrates or secondary fermentation of organic acids, such as propionate.

  12. Recombinant human TAT-OP1 to enhance NGF neurogenic potential: preliminary studies on PC12 cells.

    PubMed

    Di Liddo, R; Grandi, C; Venturini, M; Dalzoppo, D; Negro, A; Conconi, M T; Parnigotto, P P

    2010-11-01

    Osteogenic protein 1 (OP1), also known as bone morphogenic protein-7 (BMP7), is a multifunctional cytokine with demonstrated neurogenic potential. As the recombinant OP1 (rhOP1) was shown to provide axonal guidance cues and to prevent the reduction of dendritic growth in the injury-induced cortical cultures, it was suggested that an in vivo efficient rhOP1 delivery could enhance neurite growth and functional reconnectivity in the damaged brain. In the present work, we engineered a chimeric molecule in which rhBMP7 was fused to a protein transduction domain derived from HIV-1 TAT protein to deliver the denatured recombinant BMP7 into cells and obtain its chaperone-mediated folding, circumventing the expensive and not much efficient in vitro refolding procedures. When tested on rat PC12 cells, a widely used in vitro neurogenic differentiation model, the resulting fusion protein (rhTAT-OP1) demonstrated to enter fastly into the cells, lose HIV-TAT sequence and interact with membrane receptors activating BMP pathway by SMAD 1/5/8 phosphorylation. In comparison with nerve growth factor (NGF) and BMP7, it proved itself effective to induce the formation of more organized H and M neurofilaments. Moreover, if used in combination with NGF, it stimulated a significant (P < 0.05) and more precocious dendritic outgrowth with respect to NGF alone. These results indicate that rhTAT-OP1 fused with TAT transduction domain shows neurogenic activity and may be a promising enhancer factor in NGF-based therapies.

  13. Ortho-7 bound to the active-site gorge of free and OP-conjugated acetylcholinesterase: cation-π interactions.

    PubMed

    Pathak, Arup Kumar; Bandyopadhyay, Tusar

    2016-01-01

    Despite the immense importance of cation-π interactions prevailing in bispyridinium drug acetylcholinesterase (AChE) complexes, a precise description of cation-π interactions at molecular level has remained elusive. Here, we consider a bispyridinium drug, namely, ortho-7 in three different structures of AChE, with and without complexation with organophosphorus (OP) compounds for detailed investigation using all atom molecular dynamics simulation. By quantum mechanical calculations, Y72, W86, Y124, W286, Y337, and Y341 aromatic residues of the enzyme are investigated for possible cation-π interactions with ortho-7. The cation-π interactions in each of the protein-drug complexes are studied using distance, angle, a suitable functional form of them, and electrostatic criteria. The variation of cation-π functional is remarkably consistent with that of the Columbic variation. It is clearly observed that cation-π interactions for some of the residues in the catalytic active site (CAS) and peripheral anionic site (PAS) of the enzyme are either enhanced or reduced based on the nature of OP conjugation (i.e., nerve gas, tabun or pesticide, fenamiphos) when compared with the OP-free enzyme. The strength of cation-π interaction is strongly dependent on the type OP conjugation. The effect of conjugation at CAS is also seen to influence the cation-π interaction at the PAS region. The variation of cation-π interactions on the type of conjugating OP compounds might be suggestive of a reason as to why wide spectrum drug against any OP poisoning is yet to arrive in the market.

  14. Charge carrier mobility and electronic properties of Al(Op)3: impact of excimer formation

    PubMed Central

    Friederich, Pascal; Schäfer, Bernhard; Fattori, Valeria; Sun, Xiangnan; Strunk, Timo; Meded, Velimir; Hueso, Luis E; Wenzel, Wolfgang; Ruben, Mario

    2015-01-01

    Summary We have studied the electronic properties and the charge carrier mobility of the organic semiconductor tris(1-oxo-1H-phenalen-9-olate)aluminium(III) (Al(Op)3) both experimentally and theoretically. We experimentally estimated the HOMO and LUMO energy levels to be −5.93 and −3.26 eV, respectively, which were close to the corresponding calculated values. Al(Op)3 was successfully evaporated onto quartz substrates and was clearly identified in the absorption spectra of both the solution and the thin film. A structured steady state fluorescence emission was detected in solution, whereas a broad, red-shifted emission was observed in the thin film. This indicates the formation of excimers in the solid state, which is crucial for the transport properties. The incorporation of Al(Op)3 into organic thin film transistors (TFTs) was performed in order to measure the charge carrier mobility. The experimental setup detected no electron mobility, while a hole mobility between 0.6 × 10−6 and 2.1 × 10−6 cm2·V−1·s−1 was measured. Theoretical simulations, on the other hand, predicted an electron mobility of 9.5 × 10−6 cm2·V−1·s−1 and a hole mobility of 1.4 × 10−4 cm2·V−1·s−1. The theoretical simulation for the hole mobility predicted an approximately one order of magnitude higher hole mobility than was observed in the experiment, which is considered to be in good agreement. The result for the electron mobility was, on the other hand, unexpected, as both the calculated electron mobility and chemical common sense (based on the capability of extended aromatic structures to efficiently accept and delocalize additional electrons) suggest more robust electron charge transport properties. This discrepancy is explained by the excimer formation, whose inclusion in the multiscale simulation workflow is expected to bring the theoretical simulation and experiment into agreement. PMID:26171287

  15. Detection and location of OP-degrading activity: A model to integrate education and research.

    PubMed

    Iyer, Rupa; Smith, Kevin; Kudrle, Bill; Leon, Alex

    2015-06-25

    The Environmental Sampling Research Module (ESRM) is an investigative/discovery module that provides undergraduate research experiences for students as part of an interdisciplinary research-based biotechnology curriculum at the University of Houston campus. As part of the ESRM, students collect soil samples from various locations to test for the presence of organophosphorous (OP) degrading bacteria. At the end of this research project students submit a research paper on their field and laboratory activities and discuss their experimental data and observations. Students also record the date, location of collection, and the results of testing the sample for the degradation of two pesticides, methyl parathion or paraoxon, in an electronic laboratory notebook (ELN). Each collection site is recorded on a Google Maps module and the data from student research activities is made available to other undergraduate students. This data is then used to generate a microorganism database of pesticide degrading activity and promote reading, critical thinking, and analytical skills as part of the curriculum. Our sampling of agricultural sites and wastewater within and around the city of Houston has identified seven distinct genera of OP degrading organisms, including Pseudomonas, Stenotrophomonas, Exiguobacterium, Delftia, Agrobacterium, Aeromonas, and Rhizobium. Collected strains exhibit phosphotriesterase-like enzymatic activity with isolates of Pseudomonas putida and Stenotrophomonas maltophilia capable of degrading both the phosphotriester paraoxon and the phosphorothioate methyl parathion. Using this collection of OP-degrading microorganisms, undergraduate students have evaluated their potential for enhancing the removal of harmful organophosphates and their toxic metabolites from contaminated agricultural soil and adjacent bodies of water. This analytical data can potentially be utilized for environmental and industrial applications in bioremediation and ecology providing an

  16. The Role 1 capability review: mitigation and innovation for Op HERRICK 18 and into contingency.

    PubMed

    Wheatley, Robert J

    2014-09-01

    The Role 1 orientated JRAMC of September 2012 was a welcome addition to the body of Role 1 literature. In particular, the Role 1 capability review by Hodgetts and Findlay detailed both current issues and future aspirations for Role 1 provision. This personal view considers issues still prevalent during Op HERRICK 18 namely the provision of primary healthcare by combat medical technicians on operations and the organisational issues that contribute to historical structural and attitudinal obstructions to the employment of combat medical technicians in firm base primary healthcare. It also considers a dynamically updating dashboard capable of displaying risk across the Role 1 network with the implied move to a model of continuous healthcare assurance. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  17. Hearing Pygmalion's Kiss: A Scientific Object at the Paris Opéra

    NASA Astrophysics Data System (ADS)

    Lambert, Kevin

    2014-12-01

    In 1748, in his acte de ballet Pygmalion, composer and music theorist Jean-Philippe Rameau arranged the Paris Opéra orchestra to play "nature's chord," harmonies that reproduced the overtones an expert ear could detect in every natural musical vibrating body. The following year Rameau presented his music theory to the French Royal Academy of Sciences for their endorsement. Disillusionment with the promise of Cartesian mechanics as a source of a unified understanding of nature opened up the possibility that matter might have properties beyond extension and motion, such as aversion, desire, and memory. Speculations about this material sensibility also coincided with increasing claims about the authority of spontaneous emotion and feeling. The experience of music at the opera was a significant resource for claims about the cultural authority of sensibility.

  18. STS-35 TV OPS Area of the Spacelab Payload Operations Control Center (SL POCC)

    NASA Technical Reports Server (NTRS)

    1990-01-01

    The primary objective of the STS-35 mission was round the clock observation of the celestial sphere in ultraviolet and X-Ray astronomy with the Astro-1 observatory which consisted of four telescopes: the Hopkins Ultraviolet Telescope (HUT); the Wisconsin Ultraviolet Photo-Polarimeter Experiment (WUPPE); the Ultraviolet Imaging Telescope (UIT); and the Broad Band X-Ray Telescope (BBXRT). The Huntsville Operations Support Center (HOSC) Spacelab Payload Operations Control Center (SL POCC) at the Marshall Space Flight Center (MSFC) was the air/ground communication channel used between the astronauts and ground control teams during the Spacelab missions. Teams of controllers and researchers directed on-orbit science operations, sent commands to the spacecraft, received data from experiments aboard the Space Shuttle, adjusted mission schedules to take advantage of unexpected science opportunities or unexpected results, and worked with crew members to resolve problems with their experiments. Pictured is the TV OPS area of the SL POCC.

  19. Modifications to the NASA Ames Space Station Proximity Operations (PROX OPS) Simulator

    NASA Technical Reports Server (NTRS)

    Brody, Adam

    1988-01-01

    As the United States is approaching an operational space station era, flight simulators are required to investigate human design and performance aspects associated with orbital operations. Among these are proximity operations (PROX OPS), those activities occurring within a 1-km sphere of Space Station including rendezvous, docking, rescue, and repair. The Space Station Proximity Operations Simulator at NASA Ames Research Center was modified to provide the capability for investigations into human performance aspects of proximity operations. Accurate flight equations of motion were installed to provide the appropriate visual scene to test subjects performing simulated missions. Also, the flight control system was enhanced by enabling pilot control over thruster acceleration values. Currently, research is under way to examine human performance in a variety of mission scenarios.

  20. Class A/B floating buffer BiCMOS power op-amp

    NASA Astrophysics Data System (ADS)

    Lish, C. Andrew

    1995-06-01

    A class A/B BiCMOS power op-amp designed to drive the L/R load of a disk drive head actuator is presented. The amplifier uses totem pole NMOS outputs instead of bipolar devices to avoid the high collector resistance in the simplified process used. A unique floating buffer technique regulates the quiescent totem pole current of the output devices and provides control for deep triode NMOS operation. The amplifier is capable of driving a load in all four V-I quadrants without a deadband during transition, and achieves a 0.25 A drive capacity into a 7.5- Omega load using a 5-V supply.

  1. Single-frequency tunable long-wave infrared OP-GaAs OPO for gas sensing

    NASA Astrophysics Data System (ADS)

    Armougom, J.; Clément, Q.; Melkonian, J.-M.; Dherbecourt, J.-B.; Raybaut, M.; Grisard, A.; Lallier, E.; Gérard, B.; Faure, B.; Souhaité, G.; Godard, A.

    2017-02-01

    We report on the first single-frequency nanosecond optical parametric oscillator (OPO) emitting in the longwave infrared, and use it to perform standoff detection of ammonia vapor by differential spectrometry. The OPO is based on orientation-patterned GaAs (OP-GaAs) pumped by a pulsed single-frequency Tm:YAP microlaser. Single-longitudinal mode emission is obtained owing to a nested cavity OPO (NesCOPO) scheme. The OPO is tuned over 700 nm around 10.4 μm, allowing to measure the absorption spectrum of ammonia across several lines at atmospheric pressure. The potential of this OPO for standoff detection of hazardous gases is also discussed.

  2. Neoclassical calculations for W7-X OP1.1 parameters

    NASA Astrophysics Data System (ADS)

    Landreman, Matt; Alonso, A.; Beidler, C. D.; Bozhenkov, S.; Dinklage, A.; Fuchert, G.; Geiger, J.; Hirsch, M.; Krämer-Flecken, A.; Langenberg, A.; Maassberg, H.; Mollén, A.; Pablant, N.; Pasch, E.; Satake, S.; Smith, H. M.; Traverso, P.; Turkin, Y.; Valson, P.; Velasco, J. L.; Windisch, T.; Zhang, D.; W7-X Team

    2016-10-01

    Neoclassical calculations are carried out for W7-X OP1.1 plasmas with the SFINCS code, using experimental profiles of ne, Te, and Ti. An electron root solution is found in the inner part of the plasma, consistent with measurements. Calculations are performed using a variety of assumptions for the plasma's impurity composition. Impurities modestly reduce the bootstrap current, and if a flat Zeff profile is assumed, the impurity particle flux profile resembles the Er profile due to dominance of the associated thermodynamic force. Variations of quantities on flux surfaces computed with SFINCS are also presented. The incompressible-ExB approximation is found to be quite accurate for W7-X parameters.

  3. Supporting Collaborative Model and Data Service Development and Deployment with DevOps

    NASA Astrophysics Data System (ADS)

    David, O.

    2016-12-01

    Adopting DevOps practices for model service development and deployment enables a community to engage in service-oriented modeling and data management. The Cloud Services Integration Platform (CSIP) developed the last 5 years at Colorado State University provides for collaborative integration of environmental models into scalable model and data services as a micro-services platform with API and deployment infrastructure. Originally developed to support USDA natural resource applications, it proved suitable for a wider range of applications in the environmental modeling domain. While extending its scope and visibility it became apparent community integration and adequate work flow support through the full model development and application cycle drove successful outcomes.DevOps provide best practices, tools, and organizational structures to optimize the transition from model service development to deployment by minimizing the (i) operational burden and (ii) turnaround time for modelers. We have developed and implemented a methodology to fully automate a suite of applications for application lifecycle management, version control, continuous integration, container management, and container scaling to enable model and data service developers in various institutions to collaboratively build, run, deploy, test, and scale services within minutes.To date more than 160 model and data services are available for applications in hydrology (PRMS, Hydrotools, CFA, ESP), water and wind erosion prediction (WEPP, WEPS, RUSLE2), soil quality trends (SCI, STIR), water quality analysis (SWAT-CP, WQM, CFA, AgES-W), stream degradation assessment (SWAT-DEG), hydraulics (cross-section), and grazing management (GRAS). In addition, supporting data services include soil (SSURGO), ecological site (ESIS), climate (CLIGEN, WINDGEN), land management and crop rotations (LMOD), and pesticides (WQM), developed using this workflow automation and decentralized governance.

  4. SU-E-T-193: Commissioning of An IntraOp Mobetron

    SciTech Connect

    Grzetic, S; Hessler, J; Carlson, M; James, Arthur G.

    2015-06-15

    Purpose: This study will describe the commissioning process of an Intra-Op Mobetron following the guidance of TG72 and includes a detailed method for measuring gap factors. Methods: Beam data was collected for 6, 9, and 12MeV electrons on the Mobetron using a PTW water tank and a Markus chamber. Commissioning data was collected for 3 sets of cones (0°, 15°, and 30° with respect to the water surface) that ranged in size from 3cm to 10cm diameter in half centimeter increments. Profiles were collected at six depths for all integer cones. PDI’s were taken for all cones in a path perpendicular to the water surface and then converted to dose using MEPHYSTO’s internal algorithm. The depth of maximum dose was determined from the PDD’s and used for measurement of output factors. Output factors were normalized to the 10cm flat cone. Gap factors were measured for all flat cones by raising the cone away from the water surface in defined gaps. These gap factors were measured at dmax for gaps of 1cm to 5cm in 1cm increments Gap factors and effective SSD values were calculated. Results: Output factors measured for all cones were within 3% of the representative beam data for flat cones. There is no published data on beveled cones, but the angled cone output factors agreed with the flat cones within 5%. Gap factors follow a linear pattern with the output decreasing 3–7% per centimeter gap depending on the size of the cone and energy. Effective SSD values calculated and fit a 3rd order polynomial curve with R2>0.98 for all energies. Conclusion: Commissioning of an Intra-Op Mobetron was completed with general agreement to published data. New data was published for beveled cones and a method for determining gap factors was established.

  5. The ISS as a Testbed for Future Large Astronomical Observatories: The OpTIIX Demonstration Program

    NASA Technical Reports Server (NTRS)

    Burdick, G.; Callen, P.; Ess, K.; Liu, F.; Postman, M.; Sparks, W.; Seery, B.; Thronson, H.

    2012-01-01

    Future large (diameters in excess of approx. 10 m) astronomical observatories in space will need to employ advanced technologies if they are to be affordable. Many of these technologies are ready to be validated on orbit and the International Space Station (ISS) provides a suitable platform for such demonstrations. These technologies include low-cost, low-density, highly deformable mirror segments, coupled with advanced sensing and control methods. In addition, the ISS offers available telerobotic assembly techniques to build an optical testbed that embodies this new cost-effective approach to assemble and achieve diffraction-limited optical performance for very large space telescopes. Given the importance that NASA attaches to the recommendations of the National Academy of Sciences "Decadal Survey" process, essential capabilities and technologies will be demonstrated well in advance of the next Survey, which commences in 2019. To achieve this objective, the Jet Propulsion Laboratory (JPL), NASA Johnson Space Center (JSC), NASA Goddard Space Flight Center (GSFC), and the Space Telescope Science Institute (STScI) are carrying out a Phase A/B study of the Optical Testbed and Integration on ISS eXperiment (OpTIIX). The overarching goal is to demonstrate well before the end of this decade key capabilities intended to enable very large optical systems in the decade of the 2020s. Such a demonstration will retire technical risk in the assembly, alignment, calibration, and operation of future space observatories. The OpTIIX system, as currently designed, is a six-hexagon element, segmented visual-wavelength telescope with an edge-to-edge aperture of 1.4 m, operating at its diffraction limit,

  6. OpaR Controls a Network of Downstream Transcription Factors in Vibrio parahaemolyticus BB22OP

    PubMed Central

    Kernell Burke, Alison; Guthrie, Leah T. C.; Modise, Thero; Cormier, Guy; Jensen, Roderick V.; McCarter, Linda L.; Stevens, Ann M.

    2015-01-01

    Vibrio parahaemolyticus is an emerging world-wide human pathogen that is associated with food-borne gastroenteritis when raw or undercooked seafood is consumed. Expression of virulence factors in this organism is modulated by the phenomenon known as quorum sensing, which permits differential gene regulation at low versus high cell density. The master regulator of quorum sensing in V. parahaemolyticus is OpaR. OpaR not only controls virulence factor gene expression, but also the colony and cellular morphology associated with growth on a surface and biofilm formation. Whole transcriptome Next Generation sequencing (RNA-Seq) was utilized to determine the OpaR regulon by comparing strains BB22OP (opaR+, LM5312) and BB22TR (∆opaR1, LM5674). This work, using the published V. parahaemolyticus BB22OP genome sequence, confirms and expands upon a previous microarray analysis for these two strains that used an Affymetrix GeneChip designed from the closely related V. parahaemolyticus RIMD2210633 genome sequence. Overall there was excellent correlation between the microarray and RNA-Seq data. Eleven transcription factors under OpaR control were identified by both methods and further confirmed by quantitative reverse transcription PCR (qRT-PCR) analysis. Nine of these transcription factors were demonstrated to be direct OpaR targets via in vitro electrophoretic mobility shift assays with purified hexahistidine-tagged OpaR. Identification of the direct and indirect targets of OpaR, including small RNAs, will enable the construction of a network map of regulatory interactions important for the switch between the nonpathogenic and pathogenic states. PMID:25901572

  7. Persistent explosive activity at Stromboli investigated with OP-FTIR and SO2 cameras

    NASA Astrophysics Data System (ADS)

    Burton, M. R.; La Spina, A.; Sawyer, G. M.; Harris, A. J.

    2012-12-01

    Stromboli volcano in Italy exhibits what is perhaps one of the most well-known examples of cyclic activity, in the form of its regular explosions, which send a few m3 of material 100-200 m into the air every 10-20 minutes. Recent developments in measurements of volatile release from Stromboli using a series of novel approaches have allowed this cyclic behaviour to be examined in detail. In particular, the use of an automated OP-FTIR has revealed unprecedented detail in the dynamics of degassing from individual craters at the summit of Stromboli. Furthermore, the variations in composition of explosive degassing from Stromboli demonstrate a deep source ~2 km for the gas slugs which produce explosions at this volcano, in contrast to the commonly-held view that gas coalescence at shallow depth is responsible for the behaviour. The SO2 camera has revealed fascinating new details on the dynamics of degassing at Stromboli, and has allowed direct quantification of the amount of gas released during explosions and through quiescent degassing. The remarkable observation that 99% of degassing takes place quiescently, and that the explosions, whilst apparently more significant, are in fact a secondary process compared with the mass and energy involved in background, quiet processes. The new insight that the explosions are actually only a relatively minor aspect of the activity (in terms of mass and energy) actually makes the regularity of the cyclic explosive activity still more remarkable. In this paper we present a detailed overview of the state of the art of our understanding of cyclic explosive activity at Stromboli volcano from the perspective of recent advances in geochemical monitoring of the gas emissions. We also report initial results from a multidisciplinary campaign on Stromboli which utilised both OP-FTIR and SO2 camera techniques.

  8. Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates.

    PubMed

    Radić, Zoran; Sit, Rakesh K; Garcia, Edzna; Zhang, Limin; Berend, Suzana; Kovarik, Zrinka; Amitai, Gabriel; Fokin, Valery V; Barry Sharpless, K; Taylor, Palmer

    2013-03-25

    A library of more than 200 novel uncharged oxime reactivators was used to select and refine lead reactivators of human acetylcholinesterase (hAChE) covalently conjugated with sarin, cyclosarin, VX, paraoxon and tabun. N-substituted 2-hydroxyiminoacetamido alkylamines were identified as best reactivators and reactivation kinetics of the lead oximes, RS41A and RS194B, were analyzed in detail. Compared to reference pyridinium reactivators, 2PAM and MMB4, molecular recognition of RS41A reflected in its Kox constant was compromised by an order of magnitude on average for different OP-hAChE conjugates, without significant differences in the first order maximal phosphorylation rate constant k(2). Systematic structural modifications of the RS41A lead resulted in several-fold improvement with reactivator, RS194B. Kinetic analysis indicated K(ox) reduction for RS194B as the main kinetic constant leading to efficient reactivation. Subtle structural modifications of RS194B were used to identify essential determinants for efficient reactivation. Computational molecular modeling of RS41A and RS194B interactions with VX inhibited hAChE, bound reversibly in Michaelis type complex and covalently in the pentacoordinate reaction intermediate suggests that the faster reactivation reaction is a consequence of a tighter RS194B interactions with hAChE peripheral site (PAS) residues, in particular with D74, resulting in lower interaction energies for formation of both the binding and reactivation states. Desirable in vitro reactivation properties of RS194B, when coupled with its in vivo pharmacokinetics and disposition in the body, reveal the potential of this oxime design as promising centrally and peripherally active antidotes for OP toxicity.

  9. A three-year review of emergency department admissions--Op HERRICK 4 to 9.

    PubMed

    Stalker, A; Ollerton, J; Everington, S; Russell, R; Walker, C; White, S

    2011-09-01

    This paper describes the key themes in presentations to the Emergency Department (ED) of the UK Field Hospital throughout the three-year period of April 2006 to April 2009 (Op HERRICK 4-9). Electronic ED attendance records held in the Operational Emergency Department Attendance Register (OpEDAR) were analysed with validation by Defence Analytical Services Agency and commentary by ADMEM clinical staff. This paper discusses absolute numbers of emergency department attendances ofwhich there were 11,158 recorded over the studyperiod. It does not compare them to personnel at risk or operational tempo. Ofthese attendances, 59.7% (n=6666) were U.K. military. Explosive injuries (15.2%, n=1699), particularly Improvised Explosive Devices, increased throughout the period as did gunshotwounds (7.3%, n=809). Battle injuries represented 23.3% (n=2,602) attendances and had a fatality rate of 10.9%. 38.8% (n=4327) of attendances were non-battle injuries and had a fatality rate of 0.4%. There were no fatalities in the 34.1% (n=3,800) attendances for disease. 315 fatalities were recorded (this figure relates to all attendances - not just UK personnel) with 90.2% (n=284) due to battle injuries. 59.4% (n=187) were due to explosives and 28.9% (n=91) due to gunshot wounds. Over the period, the hospital's workload was characterised by an increase in explosive and gunshot injuries. In this role, the hospital met its obligation of responding to traumatic battle injury in support of fighting power and morale. Equally, the hospital faced a high proportion of attendances for non-battle injury and illness, and by patients from the local population. Extrapolation of data enables accurate medical planning and pre-deployment training and facilitates preparation for current operations.

  10. A method for measuring total aerosol oxidative potential (OP) with the dithiothreitol (DTT) assay and comparisons between an urban and roadside site of water-soluble and total OP

    NASA Astrophysics Data System (ADS)

    Gao, Dong; Fang, Ting; Verma, Vishal; Zeng, Linghan; Weber, Rodney J.

    2017-08-01

    An automated analytical system was developed for measuring the oxidative potential (OP) with the dithiothreitol (DTT) assay of filter extracts that include both water-soluble and water-insoluble (solid) aerosol species. Three approaches for measuring total oxidative potential were compared. These include using methanol as the solvent with (1) and without (2) filtering the extract, followed by removing the solvent and reconstituting with water, and (3) extraction in pure water and performing the OP analysis in the extraction vial with the filter. The water extraction method (the third approach, with filter remaining in the vial) generally yielded the highest DTT responses with better precision (coefficient of variation of 1-5 %) and was correlated with a greater number of other aerosol components. Because no organic solvents were used, which must be mostly eliminated prior to DTT analysis, it was easiest to automate by modifying an automated analytical system for measuring water-soluble OP developed by Fang et al. (2015). Therefore, the third method was applied to the field study for the determination of total OP. Daily 23 h filter samples were collected simultaneously at a roadside (RS) and a representative urban (Georgia Tech, GT) site for two 1-month study periods, and both water-soluble (OPWS-DTT) and total (OPTotal-DTT) OP were measured. Using PM2. 5 (aerodynamic diameter < 2.5 µm) high-volume samplers with quartz filters, the OPWS-DTT-to-OPTotal-DTT ratio at the urban site was 65 % with a correlation coefficient (r) of 0.71 (N = 35; p value < 0.01), compared to a ratio of 62 % and r = 0. 56 (N = 31; p value < 0.01) at the roadside site. The same DTT analyses were performed, and similar results were found using particle composition monitors (flow rate of 16.7 L min-1) with Teflon filters. Comparison of measurements between sites showed only slightly higher levels of both OPWS-DTT and OPTotal-DTT at the RS site, indicating both OPWS-DTT and OPTotal-DTT were

  11. THE RGB AND AGB STAR NUCLEOSYNTHESIS IN LIGHT OF THE RECENT {sup 17}O(p, {alpha}){sup 14}N AND {sup 18}O(p, {alpha}){sup 15}N REACTION-RATE DETERMINATIONS

    SciTech Connect

    Palmerini, S.; Sergi, M. L.; La Cognata, M.; Pizzone, R. G.; Spitaleri, C.; Lamia, L.

    2013-02-20

    In recent years, the Trojan Horse Method (THM) has been used to investigate the low-energy cross sections of proton-induced reactions on A = 17 and A = 18 oxygen isotopes, overcoming extrapolation procedures and enhancement effects due to electron screening. In particular, the strengths of the 20 keV and 65 keV resonances in the {sup 18}O(p, {alpha}){sup 15}N and {sup 17}O(p, {alpha}){sup 14}N reactions, respectively, have been extracted, as well as the contribution of the tail of the broad 656 keV resonance in the {sup 18}O(p, {alpha}){sup 15}N reaction inside the Gamow window. The strength of the 65 keV resonance in the {sup 17}O(p, {alpha}){sup 14}N reaction, measured by means of the THM, has been used to renormalize the corresponding resonance strength in the {sup 17}O + p radiative capture channel. As a result, more accurate reaction rates for the {sup 18}O(p, {alpha}){sup 15}N, {sup 17}O(p, {alpha}){sup 14}N, and {sup 17}O(p, {gamma}){sup 18}F processes have been deduced, devoid of systematic errors due to extrapolation or the electron screening effect. Such rates have been introduced into state-of-the-art red giant branch and asymptotic giant branch (AGB) models for proton-capture nucleosynthesis coupled with extra-mixing episodes. The predicted abundances have been compared with isotopic compositions provided by geochemical analysis of presolar grains. As a result, an improved agreement is found between the models and the isotopic mix of oxide grains of AGB origins, whose composition is the signature of low-temperature proton-capture nucleosynthesis. The low {sup 14}N/{sup 15}N found in SiC grains cannot be explained by the revised nuclear reaction rates and remains a serious problem that has not been satisfactorily addressed.

  12. In Vitro and In Vivo Activities of OP0595, a New Diazabicyclooctane, against CTX-M-15-Positive Escherichia coli and KPC-Positive Klebsiella pneumoniae

    PubMed Central

    Tsutsumi, Yuko; Yamada, Keiko; Takayama, Yoshihiro; Sakakibara, Shiro; Takata, Toshihiko; Abe, Takao; Furuuchi, Takeshi; Inamura, Seiichi; Sakamaki, Yoshiaki; Tsujii, Nakako; Ida, Takashi

    2016-01-01

    Gram-negative bacteria are evolving to produce β-lactamases of increasing diversity that challenge antimicrobial chemotherapy. OP0595 is a new diazabicyclooctane serine β-lactamase inhibitor which acts also as an antibiotic and as a β-lactamase-independent β-lactam “enhancer” against Enterobacteriaceae. Here we determined the optimal concentration of OP0595 in combination with piperacillin, cefepime, and meropenem, in addition to the antibacterial activity of OP0595 alone and in combination with cefepime, in in vitro time-kill studies and an in vivo infection model against five strains of CTX-M-15-positive Escherichia coli and five strains of KPC-positive Klebsiella pneumoniae. An OP0595 concentration of 4 μg/ml was found to be sufficient for an effective combination with all three β-lactam agents. In both in vitro time-kill studies and an in vivo model of infection, cefepime-OP0595 showed stronger efficacy than cefepime alone against all β-lactamase-positive strains tested, whereas OP0595 alone showed weaker or no efficacy. Taken together, these data indicate that combinational use of OP0595 and a β-lactam agent is important to exert the antimicrobial functions of OP0595. PMID:26953205

  13. In Vitro and In Vivo Activities of OP0595, a New Diazabicyclooctane, against CTX-M-15-Positive Escherichia coli and KPC-Positive Klebsiella pneumoniae.

    PubMed

    Morinaka, Akihiro; Tsutsumi, Yuko; Yamada, Keiko; Takayama, Yoshihiro; Sakakibara, Shiro; Takata, Toshihiko; Abe, Takao; Furuuchi, Takeshi; Inamura, Seiichi; Sakamaki, Yoshiaki; Tsujii, Nakako; Ida, Takashi

    2016-05-01

    Gram-negative bacteria are evolving to produce β-lactamases of increasing diversity that challenge antimicrobial chemotherapy. OP0595 is a new diazabicyclooctane serine β-lactamase inhibitor which acts also as an antibiotic and as a β-lactamase-independent β-lactam "enhancer" against Enterobacteriaceae Here we determined the optimal concentration of OP0595 in combination with piperacillin, cefepime, and meropenem, in addition to the antibacterial activity of OP0595 alone and in combination with cefepime, in in vitro time-kill studies and an in vivo infection model against five strains of CTX-M-15-positive Escherichia coli and five strains of KPC-positive Klebsiella pneumoniae An OP0595 concentration of 4 μg/ml was found to be sufficient for an effective combination with all three β-lactam agents. In both in vitro time-kill studies and an in vivo model of infection, cefepime-OP0595 showed stronger efficacy than cefepime alone against all β-lactamase-positive strains tested, whereas OP0595 alone showed weaker or no efficacy. Taken together, these data indicate that combinational use of OP0595 and a β-lactam agent is important to exert the antimicrobial functions of OP0595.

  14. Examining the Effects of Perceived Relevance and Work-Related Subjective Well-Being on Individual Performance for Co-Op Students

    ERIC Educational Resources Information Center

    Drewery, Dave; Pretti, T. Judene; Barclay, Sage

    2016-01-01

    The purpose of this study was to examine the relationships between co-op students' perceived relevance of their work term, work-related subjective well-being (SWB), and individual performance at work. Data were collected using a survey of co-op students (n = 1,989) upon completion of a work term. Results of regression analyses testing a…

  15. Reaction of Octachlorodirhenate with a Redox-Active Tetrathiafulvalene Phosphine Ligand: Spectroscopic, Magnetic, and Structural Characterization of the Unusual Paramagnetic Salt [ReCl(2)(o-P2)(2)][Re(2)Cl(6)(o-P2)] (o-P2 = o-{P(C(6)H(5))(2)}(2)(CH(3))(2)TTF).

    PubMed

    Uzelmeier, Calvin E.; Bartley, Stuart L.; Fourmigué, Marc; Rogers, Robin; Grandinetti, Giulio; Dunbar, Kim R.

    1998-12-28

    Reaction of [(n-Bu)(4)N](2)[Re(2)Cl(8)] with the tetrathiafulvalene phosphine ligand o-{P(C(6)H(5))(2)}(2)(CH(3))(2)TTF (o-P2) in refluxing ethanol produces the mixed-nuclearity salt [ReCl(2)(o-P2)(2)][Re(2)Cl(6)(o-P2)] (1.2), composed of the mononuclear Re(III) complex (1) and the mixed-valence Re(II)-Re(III) dinuclear anion (2). The complex crystallizes as a CH(2)Cl(2) solvate in the triclinic space group P&onemacr;, a = 13.4559(1) Å, b = 20.4015(3) Å, c = 21.5538(1) Å, alpha = 88.261(1) degrees, beta = 72.987(1) degrees, gamma = 84.933(1) degrees, and Z = 2. The molecular cation consists of two trans o-P2 ligands in the equatorial plane and axial chloride ligands. The dinuclear anion adopts an eclipsed geometry with an unsymmetrical coordination environment for the two metal atoms; one Re(II) center is coordinated to a chelating o-P2 ligand and two chlorides while the other Re atom is coordinated to four chloride ligands. The dinuclear portion of the salt is a monoanion which leads to a formal bond order assignment of 3.5, based on the fact that the molecule possesses an Re(2)(5+) core. The salt was further characterized by infrared and electronic spectroscopies, electrochemistry, and variable temperature magnetic susceptibility; the presence of the individual ions in bulk samples was verified by positive and negative FAB mass spectrometry. Isolation of the two separate ions was achieved by treatment of the salt with Co(C(5)H(5))(2), which reduces the Re(III) cation to the Re(II) complex ReCl(2)(o-P2)(2) (3). This neutral compound was separated from the byproduct salt [Co(C(5)H(5))(2)][Re(2)Cl(6)(o-P2)] and reoxidized with CCl(4)/CH(2)Cl(2) or NOBF(4) to produce [ReCl(2)(o-P2)(2)][Cl] (1.[Cl]) and [ReCl(2)(o-P2)(2)][BF(4)] (1.[BF(4)]), respectively. Compounds 3, 1.[Cl], and 1.[BF(4)] were identified by a combination of infrared spectroscopy, mass spectrometry, and cyclic voltammetric measurements. Variable temperature dc susceptibility studies of [ReCl(2)(o-P

  16. Coexistence of osteoporosis (OP) and coronary artery disease (CAD) in the elderly: it is not just a by chance event.

    PubMed

    Yesil, Yusuf; Ulger, Zekeriya; Halil, Meltem; Halaçli, Burçin; Yavuz, Burcu Balam; Yeşil, Nesibe Karahan; Kuyumcu, Mehmet Emin; Cankurtaran, Mustafa; Ariogul, Servet

    2012-01-01

    Cardiovascular disease (CVD) and OP are common age-related conditions. In both cross-sectional and longitudinal epidemiologic studies, low bone mass has been related to increased frequency of CVD. But available data in geriatric population is limited. In this study we aimed to seek the possible relationship between CAD and low bone mineral density (BMD) in a large number of geriatric patients. A total of 2235 patients aged 65 years or more were included in this cross-sectional study. All patients underwent a complete geriatric assessment and evaluated for CAD and cardiovascular risk factors. BMD was measured by dual-energy X-ray absorptiometry at the lumbar spine (L1-L4) and femoral neck. BMD results were classified into three groups; normal (T-score: ≥-1.0×S.D.), osteopenia (T-score between -1.0 and -2.5×S.D.), and OP (T-score: ≤-2.5×S.D.). CAD was present in 397 (29.7%) of 1335 patients with OP, in 199 (27.4%) of 726 patients with osteopenia and in 34 (19.5%) of 174 patients with normal BMD. Multivariate regression analysis revealed that presence of OP or osteopenia increased the prevalence of CAD as an independent correlate (OR=1.643; 95% CI=1.068-2.528, p=0.030). This study highlights the need for careful evaluation of elderly patients with low BMD for possible CAD.

  17. The Opuntia streptacantha OpsHSP18 gene confers salt and osmotic stress tolerance in Arabidopsis thaliana.

    PubMed

    Salas-Muñoz, Silvia; Gómez-Anduro, Gracia; Delgado-Sánchez, Pablo; Rodríguez-Kessler, Margarita; Jiménez-Bremont, Juan Francisco

    2012-01-01

    Abiotic stress limits seed germination, plant growth, flowering and fruit quality, causing economic decrease. Small Heat Shock Proteins (sHSPs) are chaperons with roles in stress tolerance. Herein, we report the functional characterization of a cytosolic class CI sHSP (OpsHSP18) from Opuntia streptacantha during seed germination in Arabidopsis thaliana transgenic lines subjected to different stress and hormone treatments. The over-expression of the OpsHSP18 gene in A. thaliana increased the seed germination rate under salt (NaCl) and osmotic (glucose and mannitol) stress, and in ABA treatments, compared with WT. On the other hand, the over-expression of the OpsHSP18 gene enhanced tolerance to salt (150 mM NaCl) and osmotic (274 mM mannitol) stress in Arabidopsis seedlings treated during 14 and 21 days, respectively. These plants showed increased survival rates (52.00 and 73.33%, respectively) with respect to the WT (18.75 and 53.75%, respectively). Thus, our results show that OpsHSP18 gene might have an important role in abiotic stress tolerance, in particular in seed germination and survival rate of Arabidopsis plants under unfavorable conditions.

  18. 76 FR 4907 - The Consumer Operated and Oriented Plan (CO-OP) Advisory Board, February 7, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES The Consumer Operated and Oriented Plan (CO-OP) Advisory Board, February 7, 2011 AGENCY... Advisory Committee Act. DATES: Meeting Date: February 7, 2011 from 8 a.m. to 5 p.m., Eastern Standard...

  19. Air Traffic Management Technology Demonstration-1 Concept of Operations (ATD-1 ConOps), Version 3.0

    NASA Technical Reports Server (NTRS)

    Baxley, Brian T.; Johnson, William C.; Scardina, John; Shay, Richard F.

    2016-01-01

    This document describes the goals, benefits, technologies, and procedures of the Concept of Operations (ConOps) for the Air Traffic Management (ATM) Technology Demonstration #1 (ATD-1), and provides an update to the previous versions of the document [ref 1 and ref 2].

  20. Organophosphorus (OP) Pesticide Degradation in the Presence of Chlorinated Oxidants: Kinetics, Modeling, and Structure-Activity Relationships

    EPA Science Inventory

    The rates and pathways for pesticide transformation during drinking water treatment are known for only a few pesticides and under limited conditions. The resulting oxons are more toxic than the parent pesticides. The transformation rates and pathways for chlorpyrifos, an OP pest...

  1. 76 FR 11484 - Public Meeting of the Consumer Operated and Oriented Plan (CO-OP) Advisory Board, March 14, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-02

    ... Oriented Plan (CO-OP) Advisory Board, March 14, 2011 AGENCY: Centers for Medicare & Medicaid Services (CMS... Date: March 14, 2011 from 8:30 a.m. to 5 p.m., Eastern Standard Time (EST) Deadline for Meeting Registration, Presentations and Comments: March 10, 2011, 5 p.m., EST. Deadline for Requesting Special...

  2. The Melwood Manual: A Planning and Operations Manual for Horticultural Training and Work Co-op Programs.

    ERIC Educational Resources Information Center

    Melwood Horticultural Training Center, Inc., Upper Marlboro, MD.

    This manual is intended as a resource for anyone involved in planning, developing, and/or operating a horticultural training or work co-op program for the handicapped. Following an introductory chapter, the manual is divided into three parts with the greatest weight given to the second part. Part I elaborates on development of the horticulture…

  3. The Opuntia streptacantha OpsHSP18 Gene Confers Salt and Osmotic Stress Tolerance in Arabidopsis thaliana

    PubMed Central

    Salas-Muñoz, Silvia; Gómez-Anduro, Gracia; Delgado-Sánchez, Pablo; Rodríguez-Kessler, Margarita; Jiménez-Bremont, Juan Francisco

    2012-01-01

    Abiotic stress limits seed germination, plant growth, flowering and fruit quality, causing economic decrease. Small Heat Shock Proteins (sHSPs) are chaperons with roles in stress tolerance. Herein, we report the functional characterization of a cytosolic class CI sHSP (OpsHSP18) from Opuntia streptacantha during seed germination in Arabidopsis thaliana transgenic lines subjected to different stress and hormone treatments. The over-expression of the OpsHSP18 gene in A. thaliana increased the seed germination rate under salt (NaCl) and osmotic (glucose and mannitol) stress, and in ABA treatments, compared with WT. On the other hand, the over-expression of the OpsHSP18 gene enhanced tolerance to salt (150 mM NaCl) and osmotic (274 mM mannitol) stress in Arabidopsis seedlings treated during 14 and 21 days, respectively. These plants showed increased survival rates (52.00 and 73.33%, respectively) with respect to the WT (18.75 and 53.75%, respectively). Thus, our results show that OpsHSP18 gene might have an important role in abiotic stress tolerance, in particular in seed germination and survival rate of Arabidopsis plants under unfavorable conditions. PMID:22949853

  4. Organophosphorus (OP) Pesticide Degradation in the Presence of Chlorinated Oxidants: Kinetics, Modeling, and Structure-Activity Relationships

    EPA Science Inventory

    The rates and pathways for pesticide transformation during drinking water treatment are known for only a few pesticides and under limited conditions. The resulting oxons are more toxic than the parent pesticides. The transformation rates and pathways for chlorpyrifos, an OP pest...

  5. Parents' experience of undertaking an intensive cognitive orientation to daily occupational performance (CO-OP) group for children with cerebral palsy.

    PubMed

    Jackman, Michelle; Novak, Iona; Lannin, Natasha; Froude, Elspeth

    2017-05-01

    The purpose of this study was to explore the experience of parents of children with cerebral palsy (CP) who participated in an intensive cognitive orientation to daily occupational performance (CO-OP) group program addressing child chosen goals. Participants were six parents of children with CP who participated in a CO-OP upper limb task-specific training program. Parents participated in semi-structured interviews conducted via phone. A grounded theory approach was used. Interviews were transcribed verbatim and coded to identify categories and overarching themes of the parent experience of CO-OP. The theory of CO-OP for children with CP was one of offering a unique and motivating learning experience for both the child and the parent, differing from other therapeutic approaches that families had previously been involved in. Five categories were identified: the unique benefits of CO-OP; the importance of intensity; the child's motivation; challenging the parent role; and the benefits and challenges of therapy within a group context. Parents felt that CO-OP was a worthwhile intervention that leads to achievement of goals involving upper limb function and had the capacity to be transferred to future goals. Intensity of therapy and a child's motivation were identified as important factors in improvements. Further studies using quantitative research methods are warranted to investigate the benefits of CO-OP for children with neurological conditions. Implications for rehabilitation The cognitive orientation to daily occupational performance (CO-OP) is a promising upper limb cognitive motor training intervention for children with cerebral palsy. In a small sample, parents perceived that CO-OP leads to achievement of upper limb goals. Intensity of therapy, the child's motivation and the parents' ability to "step-back" were identified as important to the success of CO-OP.

  6. New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (II). In vitro detoxification of cyclosarin (GF): general screening and toxicokinetic aspects of OP scavengers.

    PubMed

    Müller, Susanne; Estour, François; Kalakuntla, Raman Kumar; Le Provost, Romain; Lafont, Olivier; Worek, Franz; Thiermann, Horst; Reiter, Georg

    2013-02-04

    As standard therapy of intoxication with organophosphorus (OP) compounds is still insufficient, developing new treatment strategies is urgently required. For evaluating potential of OP detoxification of several compounds correctly, different toxicodynamic impact of OP enantiomers has to be considered thoroughly. It has already been demonstrated that β-cyclodextrin (β-CD) derivatives with attached nucleophilic substituent iodosobenzoic acid (IBA) can be regarded as potent OP scavengers due to an accelerating effect on decay of different OP. Herein, six CD derivatives permethylated or not on CD torus as well as differently attached nucleophilic substituent IBA derivative were investigated regarding detoxification of GF as an OP model substance. Acceleration of GF detoxification could be detected for all compounds with highest rate constants for propylene chain linked nucleophilic substituents on CD derivative. In addition, fast initial binding of GF on CD could be observed and is ascribed to formation of CD complexes. Furthermore, terminal plateau phase was detected of about 1% of each enantiomer reflecting the necessity of a quantitative determination at low concentrations. Moreover, this molecular depot formation may represent an additional detoxification pathway for OP. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  7. Efforts of the National Center for Optics and Photonics Education (OP-TEC) to prepare the technician workforce for photonics industries

    NASA Astrophysics Data System (ADS)

    Hull, Dan; Souders, John

    2009-06-01

    The mission of the National Center for Optics and Photonics Education (OP-TEC) is to create a secondary-to-postsecondary "pipeline" of highly qualified and strongly motivated students and to empower high schools and community colleges to meet the urgent need for technicians in optics and photonics. This paper describes the methodologies and processes OP-TEC has developed to carry out that mission. A recently completed assessment of the need for optics and photonics technicians in American industry concluded that U.S. colleges lack the capacity to produce an adequate supply. OP-TEC's challenge is to close the gap between the supply of and demand for photonics technicians. To help increase college capacity, OP-TEC has developed and implemented a recruitment process for initiating photonics programs in U.S. colleges. This paper describes the recruitment process and its results, along with the relevant support services provided by OP-TEC. In support of its mission, OP-TEC has developed curriculum and instructional materials that prepare students for the photonics workforce. To help ensure that completers of U.S. photonics programs are workforce ready, OP-TEC uses a skill-standards-based process for developing curriculum and instructional materials. This paper reviews the foundational skill standards and explains the process for integrating them into the materials development process. The curriculum and instructional materials that result from this process are also described.1

  8. Influence of osteogenic protein-1 (OP-1;BMP-7) and transforming growth factor-beta 1 on bone formation in vitro.

    PubMed

    Cheifetz, S; Li, I W; McCulloch, C A; Sampath, K; Sodek, J

    1996-01-01

    The bone morphogenetic proteins (BMPs) and transforming growth factor-beta s (TGF-beta s), are a group of structurally related proteins which have been shown to stimulate bone formation in vivo. Since these proteins are concentrated in the organic matrix of bone and would be released during bone resorption, they are likely to have a profound effect on the remodeling bone and may provide a link between bone resorption and bone formation. We are using primary cultures of fetal rat calvarial cells (FRCC) to study the independent and combined effects of OP-1/BMP-7 and TGF-beta 1 on bone cells at different stages of differentiation in order to identify responding cell populations and target genes. We have confirmed prior reports that OP-1 stimulates, while TGF-beta 1 inhibits, osteogenic differentiation in this system. The increase in both number and size of the mineralized nodules induced by OP-1 was accompanied by increased expression of alkaline phosphatase and type I collagen with an induction of bone sialoprotein (BSP) suggesting that OP-1 stimulates both differentiation and clonal expansion of osteoblastic cells. Interestingly, TGF-beta 1 abrogated OP-1 induced nodule formation. Despite these opposing effects on osteogenic differentiation, TGF-beta 1 (Wrana et al, 1991) and OP-1 both stimulated a rapid induction of osteopontin (OPN) mRNA in confluent FRCC cultures enriched in pre-osteoblastic cells. In contrast, when OP-1 was added to nodule-forming cultures which are enriched in osteoblastic cells, there was only a weak induction of OPN. Moreover, while the expression of one marker for mature osteoblasts (BSP) was refractory to OP-1, another (osteocalcin) was markedly stimulated. Thus OP-1 has selective effects on bone matrix protein expression that are dependent on the differentiated state of the cells.

  9. Co-op students' access to shared knowledge in science-rich workplaces

    NASA Astrophysics Data System (ADS)

    Munby, Hugh; Taylor, Jennifer; Chin, Peter; Hutchinson, Nancy L.

    2007-01-01

    Wenger's (1998) concepts community of practice, brokering, and transfer explain the challenges co-operative (co-op) education students face in relating the knowledge learned in school with what they learn while participating as members of a workplace. The research for this paper is set within the contexts of the knowledge economy and increased collaboration in the workplace. The paper draws on several qualitative studies of work-based education to examine the similarities and differences between learning in the workplace and learning in school, with a focus on science education and science-rich workplaces. Barriers to connecting school knowledge and workplace knowledge include the nature of science (its purpose, accountability, and substance), the structure of knowledge in each setting, the form content knowledge takes, the sequence that the curriculum is presented in, and the gatekeeping that occurs when knowledge is accessed. The paper addresses implications for interventions in school and the workplace, with attention to the transition from school to work, and concludes by pointing to profound obstacles to connecting school knowledge with workplace knowledge.

  10. A Joint data record of tropospheric ozone from Aura-TES and MetOp-IASI

    NASA Astrophysics Data System (ADS)

    Oetjen, H.; Payne, V. H.; Neu, J. L.; Kulawik, S. S.; Edwards, D. P.; Eldering, A.; Worden, H. M.; Worden, J. R.

    2015-11-01

    The Tropospheric Emission Spectrometer (TES) on Aura and Infrared Atmospheric Sounding Interferometer (IASI) on MetOp-A together provide a time series of ten years of free-tropospheric ozone with an overlap of three years. We characterise the differences between TES and IASI ozone measurements and find that IASI's coarser vertical sensitivity leads to a small (< 5 ppb) low bias relative to TES for the free troposphere. The TES-IASI differences are not dependent on season or any other factor and hence the measurements from the two instruments can be merged, after correcting for the offset, in order to study decadal-scale changes in tropospheric ozone. We calculate time series of regional monthly mean ozone in the free troposphere over Eastern Asia, the Western United States (US), and Europe, carefully accounting for differences in spatial sampling between the instruments. We show that free-tropospheric ozone over Europe and the Western US has remained relatively constant over the past decade, but that, contrary to expectations, ozone over Asia in recent years does not continue the rapid rate of increase observed from 2004-2010.

  11. A joint data record of tropospheric ozone from Aura-TES and MetOp-IASI

    NASA Astrophysics Data System (ADS)

    Oetjen, Hilke; Payne, Vivienne H.; Neu, Jessica L.; Kulawik, Susan S.; Edwards, David P.; Eldering, Annmarie; Worden, Helen M.; Worden, John R.

    2016-08-01

    The Tropospheric Emission Spectrometer (TES) on Aura and Infrared Atmospheric Sounding Interferometer (IASI) on MetOp-A together provide a time series of 10 years of free-tropospheric ozone with an overlap of 3 years. We characterise the differences between TES and IASI ozone measurements and find that IASI's coarser vertical sensitivity leads to a small (< 5 ppb) low bias relative to TES for the free troposphere. The TES-IASI differences are not dependent on season or any other factor and hence the measurements from the two instruments can be merged, after correcting for the offset, in order to study decadal-scale changes in tropospheric ozone. We calculate time series of regional monthly mean ozone in the free troposphere over eastern Asia, the western United States (US), and Europe, carefully accounting for differences in spatial sampling between the instruments. We show that free-tropospheric ozone over Europe and the western US has remained relatively constant over the past decade but that, contrary to expectations, ozone over Asia in recent years does not continue the rapid rate of increase observed from 2004 to 2010.

  12. Global Patterns of Abundance, Diversity and Community Structure of the Aminicenantes (Candidate Phylum OP8)

    PubMed Central

    Farag, Ibrahim F.; Davis, James P.; Youssef, Noha H.; Elshahed, Mostafa S.

    2014-01-01

    We investigated the global patterns of abundance, diversity, and community structure of members of the Aminicenantes (candidate phylum OP8). Our aim was to identify the putative ecological role(s) played by members of this poorly characterized bacterial lineages in various ecosystems. Analysis of near full-length 16S rRNA genes identified four classes and eight orders within the Aminicenantes. Within 3,134 datasets comprising ∼1.8 billion high throughput-generated partial 16S rRNA genes, 47,351 Aminicenantes-affiliated sequences were identified in 913 datasets. The Aminicenantes exhibited the highest relative abundance in hydrocarbon-impacted environments, followed by marine habitats (especially hydrothermal vents and coral-associated microbiome samples), and aquatic, non-marine habitats (especially in terrestrial springs and groundwater samples). While the overall abundance of the Aminicenantes was higher in low oxygen tension as well as non-saline and low salinity habitats, it was encountered in a wide range of oxygen tension, salinities, and temperatures. Analysis of the community structure of the Aminicenantes showed distinct patterns across various datasets that appear to be, mostly, driven by habitat variations rather than prevalent environmental parameters. We argue that the detection of the Aminicenantes across environmental extremes and the observed distinct community structure patterns reflect a high level of intraphylum metabolic diversity and adaptive capabilities that enable its survival and growth in a wide range of habitats and environmental conditions. PMID:24637619

  13. Modeling structure-activity relationships of prodiginines with antimalarial activity using GA/MLR and OPS/PLS.

    PubMed

    de Campos, Luana Janaína; de Melo, Eduardo Borges

    2014-11-01

    In the present study, we performed a multivariate quantitative structure-activity relationship (QSAR) analysis of 52 prodiginines with antimalarial activity. Variable selection was based on the genetic algorithm (GA) and ordered predictor selection (OPS) approaches, and the models were built using the multiple linear regression (MLR) and partial least squares (PLS) regression methods. The leave-N-out crossvalidation and y-randomization tests showed that the models were robust and free from chance correlation. The mechanistic interpretation of the results was supported by earlier findings. In addition, the comparison of our models with those previously described indicated that the OPS/PLS-based model had a higher quality of external prediction. Thus, this study provides a comprehensive approach to the evaluation of the antimalarial activity of prodiginines, which may be used as a support tool in designing new therapeutic agents for malaria.

  14. Glutathione transferase in the decontamination of OP toxins and chlorinated hydrocarbons. Final report, 1 April 1994-31 March 1997

    SciTech Connect

    Syvanen, M.

    1997-04-30

    The enzyme glutathione transferase degrades organophosphate (OP) triester insecticides. Our research is targeted toward developing these enzymes for their use in nerve gas decontamination technology. To this end, progress has been made in several areas: (1) Genes and enzymes have been characterized and sequenced from the housefly; (2) the genomic loci of those genes responsible for OP resistant housefly mutants have been partially characterized; (3) Work is progressing on engineering housefly GSTs so that new enzymes with enhanced degradative activities against nerve gas can be created; and (4) In order to adapt bacteria to incorporate these modified enzymes so that they can eat these toxins, we have been studying the regulation of synthesis of the native GST from the bacterium E. coli and also the normal physiology of GST in bacteria.

  15. Behind the scenes of the Patient Protection and Affordable Care Act: the making of a health care co-op.

    PubMed

    Giaimo, Susan

    2013-06-01

    A primary goal of the Patient Protection and Affordable Care Act (PPACA) is to reduce the number of uninsured by making health insurance more affordable for small businesses and individuals. Toward that end, the PPACA encourages the creation of nonprofit, member-owned health insurance cooperatives to operate inside each state exchange. Co-ops face significant challenges in entering mature insurance markets, but they also possess unique characteristics that may help them survive and thrive. Using Common Ground Healthcare Cooperative in Wisconsin as a case study, this article traces the origins of co-ops in health care reform at national and state levels and analyzes the political and technical challenges and opportunities facing these organizations.

  16. Characterization of a unique OpMNPV-specific early gene not required for viral infection in tissue culture.

    PubMed

    Shippam, C; Wu, X; Stewart, S; Theilmann, D A

    1997-01-20

    opep-2 is an Orgyia pseudotsugata multicapsid nucleopolyhedrovirus (OpMNPV) early gene in the ie1-ie2 gene region for which there is no homolog in either the archetype virus, Autographa californica MNPV, or Bombyx mori NPV. opep-2 is transcribed immediately upon infection as three mRNAs which initiate from a early gene motif (TATA-N27-CAGT). The expression of multiple transcripts at very early times postinfection has only been previously described for the baculovirus early gene ie1, which produces spliced mRNAs. However, distinct from ie1, the multiple mRNAs of opep-2 are due to multiple termination sites and not splicing. Western blot analysis of steady-state levels of OPEP-2 showed that in OpMNPV-infected Ld652Y cells maximum levels are obtained at 8-12 hr postinfection (p.i.) prior to DNA replication. By 48 hr p.i. OPEP-2 is shut off and is undetectable. To aid in elucidating the function of this OpMNPV-specific gene an opep-2 deletion mutant was generated and was compared to wild-type virus to determine if its absence affects viral growth in Ld652Y tissue culture cells.

  17. On the stability of a POCsp3OP-type pincer ligand in nickel(II) complexes.

    PubMed

    Hao, Jingjun; Mougang-Soumé, Berline; Vabre, Boris; Zargarian, Davit

    2014-03-17

    We describe the results of a study on the stabilities of pincer-type nickel complexes relevant to catalytic hydroalkoxylation and hydroamination of olefins, C-C and C-X couplings, and fluorination of alkyl halides. Complexes [(POCsp3 OP)NiX] are stable for X=OSiMe3 , OMes (Mes=1,3,5-Me3 C6 H2), NPh2, and CC-H, whereas the O(tBu) and N(SiMe3)2 derivatives decompose readily. The phenylacetylide derivative transforms gradually into the zero-valent species cis-[{κ(P),κ(C),κ(C')-(iPr2 POCH2 CHCH2 )}Ni{η(2),κ(C),κ(C')-(iPr2 P(O)CCPh)}]. Likewise, attempts to prepare [(POCsp3 OP)NiF] gave instead the zwitterionic trinuclear species [{(η(3) -allyl)Ni}2-{μ,κ(P),κ(O)-(iPr2 PO)4 Ni}]. Characterization of these two complexes provides concrete examples of decomposition processes that can dismantle POCsp3 OP-type pincer ligands by facile C-O bond rupture. These results serve as a cautionary tale for the inherent structural fragility of pincer systems bearing phosphinite donor moieties, and provide guidelines on how to design more robust analogues. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Natural weathering studies of oil palm trunk lumber (OPTL) green polymer composites enhanced with oil palm shell (OPS) nanoparticles.

    PubMed

    Islam, Md Nazrul; Dungani, Rudi; Abdul Khalil, Hps; Alwani, M Siti; Nadirah, Wo Wan; Fizree, H Mohammad

    2013-01-01

    In this study, a green composite was produced from Oil Palm Trunk Lumber (OPTL) by impregnating oil palm shell (OPS) nanoparticles with formaldehyde resin. The changes of physical, mechanical and morphological properties of the OPS nanoparticles impregnated OPTL as a result of natural weathering was investigated. The OPS fibres were ground with a ball-mill for producing nanoparticles before being mixed with the phenol formaldehyde (PF) resin at a concentration of 1, 3, 5 and 10% w/w basis and impregnated into the OPTL by vacuum-pressure method. The treated OPTL samples were exposed to natural weathering for the period of 6 and 12 months in West Java, Indonesia according to ASTM D1435-99 standard. Physical and mechanical tests were done for analyzing the changes in phenol formaldehyde-nanoparticles impregnated (PF-NPI) OPTL. FT-IR and SEM studies were done to analyze the morphological changes. The results showed that both exposure time of weathering and concentration of PF-NPI had significant impact on physical and mechanical properties of OPTL. The longer exposure of samples to weathering condition reduced the wave numbers during FT-IR test. However, all these physical, mechanical and morphological changes were significant when compared with the untreated samples or only PF impregnated samples. Thus, it can be concluded that PF-NP impregnation into OPTL improved the resistance against natural weathering and would pave the ground for improved products from OPTL for outdoor conditions.

  19. Single-cell and metagenomic analyses indicate a fermentative and saccharolytic lifestyle for members of the OP9 lineage

    PubMed Central

    Dodsworth, Jeremy A.; Blainey, Paul C.; Murugapiran, Senthil K.; Swingley, Wesley D.; Ross, Christian A.; Tringe, Susannah G.; Chain, Patrick S. G.; Scholz, Matthew B.; Lo, Chien-Chi; Raymond, Jason; Quake, Stephen R.; Hedlund, Brian P.

    2013-01-01

    OP9 is a yet-uncultivated bacterial lineage found in geothermal systems, petroleum reservoirs, anaerobic digesters, and wastewater treatment facilities. Here we use single-cell and metagenome sequencing to obtain two distinct, nearly-complete OP9 genomes, one constructed from single cells sorted from hot spring sediments and the other derived from binned metagenomic contigs from an in situ-enriched cellulolytic, thermophilic community. Phylogenomic analyses support the designation of OP9 as a candidate phylum for which we propose the name ‘Atribacteria’. Although a plurality of predicted proteins is most similar to those from Firmicutes, the presence of key genes suggests a diderm cell envelope. Metabolic reconstruction from the core genome suggests an anaerobic lifestyle based on sugar fermentation by Embden-Meyerhof glycolysis with production of hydrogen, acetate, and ethanol. Putative glycohydrolases and an endoglucanase may enable catabolism of (hemi)cellulose in thermal environments. This study lays a foundation for understanding the physiology and ecological role of the ‘Atribacteria’. PMID:23673639

  20. NINJA-OPS: Fast Accurate Marker Gene Alignment Using Concatenated Ribosomes

    PubMed Central

    Al-Ghalith, Gabriel A.; Montassier, Emmanuel; Ward, Henry N.; Knights, Dan

    2016-01-01

    The explosion of bioinformatics technologies in the form of next generation sequencing (NGS) has facilitated a massive influx of genomics data in the form of short reads. Short read mapping is therefore a fundamental component of next generation sequencing pipelines which routinely match these short reads against reference genomes for contig assembly. However, such techniques have seldom been applied to microbial marker gene sequencing studies, which have mostly relied on novel heuristic approaches. We propose NINJA Is Not Just Another OTU-Picking Solution (NINJA-OPS, or NINJA for short), a fast and highly accurate novel method enabling reference-based marker gene matching (picking Operational Taxonomic Units, or OTUs). NINJA takes advantage of the Burrows-Wheeler (BW) alignment using an artificial reference chromosome composed of concatenated reference sequences, the “concatesome,” as the BW input. Other features include automatic support for paired-end reads with arbitrary insert sizes. NINJA is also free and open source and implements several pre-filtering methods that elicit substantial speedup when coupled with existing tools. We applied NINJA to several published microbiome studies, obtaining accuracy similar to or better than previous reference-based OTU-picking methods while achieving an order of magnitude or more speedup and using a fraction of the memory footprint. NINJA is a complete pipeline that takes a FASTA-formatted input file and outputs a QIIME-formatted taxonomy-annotated BIOM file for an entire MiSeq run of human gut microbiome 16S genes in under 10 minutes on a dual-core laptop. PMID:26820746

  1. OCRA radiometric cloud fractions for GOME-2 on MetOp-A/B

    NASA Astrophysics Data System (ADS)

    Lutz, R.; Loyola, D.; Gimeno García, S.; Romahn, F.

    2015-12-01

    This paper describes an approach for cloud parameter retrieval (radiometric cloud fraction estimation) using the polarization measurements of the Global Ozone Monitoring Experiment-2 (GOME-2) on-board the MetOp-A/B satellites. The core component of the Optical Cloud Recognition Algorithm (OCRA) is the calculation of monthly cloud-free reflectances for a global grid (resolution of 0.2° in longitude and 0.2° in latitude) and to derive radiometric cloud fractions. These cloud fractions will serve as a priori information for the retrieval of cloud top height (CTH), cloud top pressure (CTP), cloud top albedo (CTA) and cloud optical thickness (COT) with the Retrieval Of Cloud Information using Neural Networks (ROCINN) algorithm. This approach is already being implemented operationally for the GOME/ERS-2 and SCIAMACHY/ENVISAT sensors and here we present version 3.0 of the OCRA algorithm applied to the GOME-2 sensors. Based on more than six years of GOME-2A data (February 2007-June 2013), reflectances are calculated for ≈ 35 000 orbits. For each measurement a degradation correction as well as a viewing angle dependent and latitude dependent correction is applied. In addition, an empirical correction scheme is introduced in order to remove the effect of oceanic sun glint. A comparison of the GOME-2A/B OCRA cloud fractions with co-located AVHRR geometrical cloud fractions shows a general good agreement with a mean difference of -0.15±0.20. From operational point of view, an advantage of the OCRA algorithm is its extremely fast computational time and its straightforward transferability to similar sensors like OMI (Ozone Monitoring Instrument), TROPOMI (TROPOspheric Monitoring Instrument) on Sentinel 5 Precursor, as well as Sentinel 4 and Sentinel 5. In conclusion, it is shown that a robust, accurate and fast radiometric cloud fraction estimation for GOME-2 can be achieved with OCRA by using the polarization measurement devices (PMDs).

  2. Universal School-Based Depression Prevention 'Op Volle Kracht': a Longitudinal Cluster Randomized Controlled Trial.

    PubMed

    Tak, Yuli R; Lichtwarck-Aschoff, Anna; Gillham, Jane E; Van Zundert, Rinka M P; Engels, Rutger C M E

    2016-07-01

    The longitudinal effectiveness of a universal, adolescent school-based depression prevention program Op Volle Kracht (OVK) was evaluated by means of a cluster randomized controlled trial with intervention and control condition (school as usual). OVK was based on the Penn Resiliency Program (PRP) (Gillham et al. Psychological Science, 6, 343-351, 1995). Depressive symptoms were assessed with the Child Depression Inventory (Kovacs 2001). In total, 1341 adolescents participated, Mage = 13.91, SD = 0.55, 47.3 % girls, 83.1 % Dutch ethnicity; intervention group n = 655, four schools; control group n = 735, five schools. Intent-to-treat analyses revealed that OVK did not prevent depressive symptoms, β = -0.01, SE = 0.05, p = .829, Cohen's d = 0.02, and the prevalence of an elevated level of depressive symptoms was not different between groups at 1 year follow-up, OR = 1.00, 95 % CI = 0.60-1.65, p = .992, NNT = 188. Latent Growth Curve Modeling over the 2 year follow-up period showed that OVK did not predict differences in depressive symptoms immediately following intervention, intercept: β = 0.02, p = .642, or changes in depressive symptoms, slope: β = -0.01, p = .919. No moderation by gender or baseline depressive symptoms was found. To conclude, OVK was not effective in preventing depressive symptoms across the 2 year follow-up. The implications of these findings are discussed.

  3. Mechanism for the catastrophe-promoting activity of the microtubule destabilizer Op18/stathmin.

    PubMed

    Gupta, Kamlesh K; Li, Chunlei; Duan, Aranda; Alberico, Emily O; Kim, Oleg V; Alber, Mark S; Goodson, Holly V

    2013-12-17

    Regulation of microtubule dynamic instability is crucial for cellular processes, ranging from mitosis to membrane transport. Stathmin (also known as oncoprotein 18/Op18) is a prominent microtubule destabilizer that acts preferentially on microtubule minus ends. Stathmin has been studied intensively because of its association with multiple types of cancer, but its mechanism of action remains controversial. Two models have been proposed. One model is that stathmin promotes microtubule catastrophe indirectly, and does so by sequestering tubulin; the other holds that stathmin alters microtubule dynamics by directly destabilizing growing microtubules. Stathmin's sequestration activity is well established, but the mechanism of any direct action is mysterious because stathmin binds to microtubules very weakly. To address these issues, we have studied interactions between stathmin and varied tubulin polymers. We show that stathmin binds tightly to Dolastatin-10 tubulin rings, which mimic curved tubulin protofilaments, and that stathmin depolymerizes stabilized protofilament-rich polymers. These observations lead us to propose that stathmin promotes catastrophe by binding to and acting upon protofilaments exposed at the tips of growing microtubules. Moreover, we suggest that stathmin's minus-end preference results from interactions between stathmin's N terminus and the surface of α-tubulin that is exposed only at the minus end. Using computational modeling of microtubule dynamics, we show that these mechanisms could account for stathmin's observed activities in vitro, but that both the direct and sequestering activities are likely to be relevant in a cellular context. Taken together, our results suggest that stathmin can promote catastrophe by direct action on protofilament structure and interactions.

  4. Conventional slow freezing, vitrification and open pulled straw (OPS) vitrification of rabbit embryos.

    PubMed

    Naik, B R; Rao, B S; Vagdevi, R; Gnanprakash, M; Amarnath, D; Rao, V H

    2005-04-01

    Three different methods of cryopreservation viz., conventional slow freezing, vitrification and open pulled straw vitrification were compared for their ability to support post thaw in vitro and in vivo development of rabbit embryos. Morula stage rabbit embryos were collected from super-ovulated donor does. They were randomly allocated to different freezing methods and stored up to 3 months in liquid nitrogen. After thawing and removal of cryoprotectants, embryos exhibiting intact zona pellucida and uniform blastomeres were considered suitable for in vitro culture and/or transfer. Three to five cryopreserved embryos placed in approximately 1 ml of culture medium (TCM 199 supplemented with foetal calf serum and antibiotics) were incubated for up to 72 h under humidified atmosphere of 5% CO2 in air at 39 degrees C. Development to hatched blastocyst stage was considered the initial indicator of success of cryopreservation of embryos. Of the embryos cryopreserved by programmed freezing, open pulled straw vitrification, vitrification-55 h pc and vitrification-72 h pc 55, 71, 17 and 48%, respectively, developed into hatched blastocysts. Similarly 19, 29, and 4% of embryos cryopreserved by programmed freezing, open pulled straw vitrification and vitrification -72 h pc developed into live offspring on transfer to recipient does. This is the first report on open pulled straw vitrification of rabbit embryos. Present results, suggest that (a) open pulled straw vitrification supports better in vitro survival of frozen thawed rabbit morulae; (b) both programmed freezing and OPS are similar but superior to vitirification in supporting in vivo survival of frozen thawed rabbit embryos.

  5. NINJA-OPS: Fast Accurate Marker Gene Alignment Using Concatenated Ribosomes.

    PubMed

    Al-Ghalith, Gabriel A; Montassier, Emmanuel; Ward, Henry N; Knights, Dan

    2016-01-01

    The explosion of bioinformatics technologies in the form of next generation sequencing (NGS) has facilitated a massive influx of genomics data in the form of short reads. Short read mapping is therefore a fundamental component of next generation sequencing pipelines which routinely match these short reads against reference genomes for contig assembly. However, such techniques have seldom been applied to microbial marker gene sequencing studies, which have mostly relied on novel heuristic approaches. We propose NINJA Is Not Just Another OTU-Picking Solution (NINJA-OPS, or NINJA for short), a fast and highly accurate novel method enabling reference-based marker gene matching (picking Operational Taxonomic Units, or OTUs). NINJA takes advantage of the Burrows-Wheeler (BW) alignment using an artificial reference chromosome composed of concatenated reference sequences, the "concatesome," as the BW input. Other features include automatic support for paired-end reads with arbitrary insert sizes. NINJA is also free and open source and implements several pre-filtering methods that elicit substantial speedup when coupled with existing tools. We applied NINJA to several published microbiome studies, obtaining accuracy similar to or better than previous reference-based OTU-picking methods while achieving an order of magnitude or more speedup and using a fraction of the memory footprint. NINJA is a complete pipeline that takes a FASTA-formatted input file and outputs a QIIME-formatted taxonomy-annotated BIOM file for an entire MiSeq run of human gut microbiome 16S genes in under 10 minutes on a dual-core laptop.

  6. Partial Optimization of the 5-Terminal Codon Increased a Recombination Porcine Pancreatic Lipase (opPPL) Expression in Pichia pastoris

    PubMed Central

    Zhao, Hua; Chen, Dan; Tang, Jiayong; Jia, Gang; Long, Dingbiao; Liu, Guangmang; Chen, Xiaoling; Shang, Haiying

    2014-01-01

    Pancreatic lipase plays a key role in intestinal digestion of feed fat, and is often deficient in young animals such as weaning piglets. The objective of this study was to express and characterize a partial codon optimized porcine pancreatic lipase (opPPL). A 537 bp cDNA fragment encoding N-terminus amino acid residue of the mature porcine pancreatic lipase was synthesized according to the codon bias of Pichia pastoris and ligated to the full-length porcine pancreatic lipase cDNA fragment. The codon optimized PPL was cloned into the pPICZαA (Invitrogen, Beijing, China) vector. After the resultant opPPL/pPICZαΑ plasmid was transformed into P.pastoris, the over-expressed extracellular opPPL containing a His-tag to the C terminus was purified using Ni Sepharose affinity column (GE Healthcare, Piscataway, NJ, USA), and was characterized against the native enzyme (commercial PPL from porcine pancreas, Sigma). The opPPL exhibited a molecular mass of approximately 52 kDa, and showed optimal temperature (40°C), optimal pH (8.0), Km (0.041 mM), and Vmax (2.008 µmol.mg protein −1.min−1) similar to those of the commercial enzyme with p-NPP as the substrate. The recombinant enzyme was stable at 60°C, but lost 80% (P<0.05) of its activity after exposure to heat ≥60°C for 20 min. The codon optimization increased opPPL yield for ca 4 folds (146 mg.L−1 vs 36 mg.L−1) and total enzyme activity increased about 5 folds (1900 IU.L−1 vs 367 IU.L−1) compared with those native naPPL/pPICZαΑ tranformant. Comparison of gene copies and mRNA profiles between the two strains indicated the increased rePPL yields may partly be ascribed to the increased protein translational efficiency after codon optimization. In conclusion, we successfully optimized 5-terminal of porcine pancreatic lipase encoding gene and over-expressed the gene in P. pastoris as an extracellular, functional enzyme. The recombination enzyme demonstrates a potential for future use as an animal feed

  7. Situationeel Bewustzijn en Vestibulaire Stimulatie: De Invloed Van Draaibewegingen op de Taakprestatie (Situational Awareness and Vestibular Stimulation: The Influence of Whole-Body Rotation upon Task Performance)

    DTIC Science & Technology

    1989-08-01

    of the vestibular-ocular reflex (VOR). These findings are of importance for the problem of "situational awareness’ because similar reactions might...ergonomic, training , seloctie en preventie. 1.1 Situatigneel bewustziin Do problemen rand do invlood van niet allodaagse bewegingen op hot functioneren...informatieverwerking. In dit ondorzoek is aandscht bestood aan do volgondo vorschijnselon: - Do vostibulo-oculaire reflex Stabilisatie van do blik op eon

  8. REMOTE LAND MINE(FIELD) DETECTION. An Overview of Techniques (DETECTIE VAN LANDMIJNEN EN MIJNENVELDEN OP AFSTAND. Een Overzicht van de technieken),

    DTIC Science & Technology

    1994-09-01

    systeem voor mijnen of mijnenvelden essentieel. De basis principes en sterke en zwakke punten van "real time" mijnen detectie met visuele, nabij...tweede deel van het rapport worden aanbevelingen gegeven voor een toekomstig systeem voor de detectie van mijnen. Deze aanbevelingen zijn gebaseerd...multi-sensor systeem voor op een voertuig. Dit is gebaseerd op de interesse die de "Genie" toont voor een dergelijk systeem , de kosten van een

  9. Vinblastine differs from Taxol as it inhibits the malignant phenotypes of NSCLC cells by increasing the phosphorylation of Op18/stathmin.

    PubMed

    Shen, Fang; Long, Dan; Yu, Ting; Chen, Xian; Liao, Ying; Wu, Yi; Lin, Xuechi

    2017-04-01

    Taxol (paclitaxel) and vinblastine (VBL) are both efficacious chemotherapeutic agents that target the microtubules of tumor cells, but each functions in a mutual antagonistic manner. Op18/stathmin is a small molecular phosphoprotein which promotes depolymerization of microtubules. Non-small cell lung cancer (NSCLC) NCI-H1299 cells were employed to compare the curative effects of VBL and Taxol and explore the correlation between drug sensitivity and Op18/stathmin signaling. The present study found that VBL obviously promoted cellular apoptosis and initiated activation of caspase 3 and 9, and inhibited cell proliferation and colony formation, as well as cell migration in the NCI-H1299 cells in contrast with Taxol. VBL did not affect the expression of Op18/stathmin, but increased its phosphorylation at all 4 serine sites. Conversely, Taxol mainly decreased the expression of Op18/stathmin and the phosphorylation at Ser25 and Ser63 sites. Silencing of Op18/stathmin by RNA interference (RNAi) led to a great reduction in the differences in the cell proliferation inhibition between VBL and Taxol. VBL treatment notably weakened the expression of PP2A, Bcl-2, NF-κB and interleukin-10 (IL-10) and autocrine IL-10 compared with Taxol; whereas PP2A was substantially increased following Taxol induction. High expression of Op18/stathmin was found to be negatively correlated with the sensitivity of Taxol in the NSCLC cells, but had a minor impact on VBL cytotoxicity. These findings revealed that both VBL and Taxol induce cell apoptosis through Op18/stathmin, but the mechanisms are completely different. VBL is an attractive alternative to the treatment of Taxol-resistant tumors with high expression of Op18/stathmin.

  10. Optogenetic manipulation of cGMP in cells and animals by the tightly light-regulated guanylyl-cyclase opsin CyclOp.

    PubMed

    Gao, Shiqiang; Nagpal, Jatin; Schneider, Martin W; Kozjak-Pavlovic, Vera; Nagel, Georg; Gottschalk, Alexander

    2015-09-08

    Cyclic GMP (cGMP) signalling regulates multiple biological functions through activation of protein kinase G and cyclic nucleotide-gated (CNG) channels. In sensory neurons, cGMP permits signal modulation, amplification and encoding, before depolarization. Here we implement a guanylyl cyclase rhodopsin from Blastocladiella emersonii as a new optogenetic tool (BeCyclOp), enabling rapid light-triggered cGMP increase in heterologous cells (Xenopus oocytes, HEK293T cells) and in Caenorhabditis elegans. Among five different fungal CyclOps, exhibiting unusual eight transmembrane topologies and cytosolic N-termini, BeCyclOp is the superior optogenetic tool (light/dark activity ratio: 5,000; no cAMP production; turnover (20 °C) ∼17 cGMP s(-1)). Via co-expressed CNG channels (OLF in oocytes, TAX-2/4 in C. elegans muscle), BeCyclOp photoactivation induces a rapid conductance increase and depolarization at very low light intensities. In O2/CO2 sensory neurons of C. elegans, BeCyclOp activation evokes behavioural responses consistent with their normal sensory function. BeCyclOp therefore enables precise and rapid optogenetic manipulation of cGMP levels in cells and animals.

  11. Baculovirus Inhibitor-of-Apoptosis Op-IAP3 Blocks Apoptosis by Interaction with and Stabilization of a Host Insect Cellular IAP

    PubMed Central

    Byers, Nathaniel M.; Vandergaast, Rianna L.

    2015-01-01

    ABSTRACT Baculovirus-encoded inhibitor of apoptosis (IAP) proteins likely evolved from their host cell IAP homologs, which function as critical regulators of cell death. Despite their striking relatedness to cellular IAPs, including the conservation of two baculovirus IAP repeat (BIR) domains and a C-terminal RING, viral IAPs use an unresolved mechanism to suppress apoptosis in insects. To define this mechanism, we investigated Op-IAP3, the prototypical IAP from baculovirus OpMNPV. We found that Op-IAP3 forms a stable complex with SfIAP, the native, short-lived IAP of host insect Spodoptera frugiperda. Long-lived Op-IAP3 prevented virus-induced SfIAP degradation, which normally causes caspase activation and apoptosis. In uninfected cells, Op-IAP3 also increased SfIAP steady-state levels and extended SfIAP's half-life. Conversely, SfIAP stabilization was lost or reversed in the presence of mutated Op-IAP3 that was engineered for reduced stability. Thus, Op-IAP3 stabilizes SfIAP and preserves its antiapoptotic function. In contrast to SfIAP, Op-IAP3 failed to bind or inhibit native Spodoptera caspases. Furthermore, BIR mutations that abrogate binding of well-conserved IAP antagonists did not affect Op-IAP3's capacity to prevent virus-induced apoptosis. Remarkably, Op-IAP3 also failed to prevent apoptosis when endogenous SfIAP was ablated by RNA silencing. Thus, Op-IAP3 requires SfIAP as a cofactor. Our findings suggest a new model wherein Op-IAP3 interacts directly with SfIAP to maintain its intracellular level, thereby suppressing virus-induced apoptosis indirectly. Consistent with this model, Op-IAP3 has evolved an intrinsic stability that may serve to repress signal-induced turnover and autoubiquitination when bound to its targeted cellular IAP. IMPORTANCE The IAPs were first discovered in baculoviruses because of their potency for preventing apoptosis. However, the antiapoptotic mechanism of viral IAPs in host insects has been elusive. We show here that the

  12. Insights into different Strombolian explosive styles by remote controlled OP-FTIR (CERBERUS) measurements

    NASA Astrophysics Data System (ADS)

    Spina Alessandro, La; Mike, Burton; Filippo, Murè; Roberto, Maugeri

    2014-05-01

    In this paper we present the results and interpretation of gas composition data collected by a permanent OP-FTIR system (CERBERUS) installed at Stromboli summit. The instrument allows remote control observation and measurement of gas emissions from different points within volcano's crater terrace, using an integrated infrared camera / scanning mirror / FTIR system. Given that an OpenPath Fourier Transform InfraRed (FTIR) spectrometer allows the simultaneously measure all the major species contained in volcanic gas emissions, we could observe the different explosive styles fed by Stromboli volcano. Stromboli volcano, in the Aeolian island arc, is known as the "Lighthouse of the Mediterranean" for its regular (~every 10-20 min) explosive activity, launching crystal-rich black scoriae to 100-200 m height constituting a rich and impressive spectacle for both volcanologists and tourists from every part of the world. This ordinary activity has been classified in two types in relation to the their content of ash ejected. Type 1 is dominated melt ballistic particles whereas Type 2 consists of an ash-rich plume. On 18 July we recorded both explosive styles at the SW crater of Stromboli finding quite similar CO2/SO2 ratio, although we observed a higher value of SO2/HCl molar ratio for the Type 2. Moreover prior to both types of explosions the CO2 amount showed similar trend, whereas a different pattern in SO2 and in HCl gas content, was observed. In detail type 2 was preceded by decrease in SO2 and HCl amounts with respect to type 1. The decreasing trend observed before the onset of style 2 and the higher SO2/HCl ratio might be an indication of overpressure that might have induced the difference between the two types of explosions. In this context, the evidence of no change in the amount of CO2 and in CO2/SO2 ratio suggested us that this overpressure occurred in very shallow depths within the volcano feeding system. If our observations will be confirmed by other explosive

  13. OCRA radiometric cloud fractions for GOME-2 on MetOp-A/B

    NASA Astrophysics Data System (ADS)

    Lutz, Ronny; Loyola, Diego; Gimeno García, Sebastián; Romahn, Fabian

    2016-05-01

    This paper describes an approach for cloud parameter retrieval (radiometric cloud-fraction estimation) using the polarization measurements of the Global Ozone Monitoring Experiment-2 (GOME-2) onboard the MetOp-A/B satellites. The core component of the Optical Cloud Recognition Algorithm (OCRA) is the calculation of monthly cloud-free reflectances for a global grid (resolution of 0.2° in longitude and 0.2° in latitude) to derive radiometric cloud fractions. These cloud fractions will serve as a priori information for the retrieval of cloud-top height (CTH), cloud-top pressure (CTP), cloud-top albedo (CTA) and cloud optical thickness (COT) with the Retrieval Of Cloud Information using Neural Networks (ROCINN) algorithm. This approach is already being implemented operationally for the GOME/ERS-2 and SCIAMACHY/ENVISAT sensors and here we present version 3.0 of the OCRA algorithm applied to the GOME-2 sensors. Based on more than five years of GOME-2A data (April 2008 to June 2013), reflectances are calculated for ≈ 35 000 orbits. For each measurement a degradation correction as well as a viewing-angle-dependent and latitude-dependent correction is applied. In addition, an empirical correction scheme is introduced in order to remove the effect of oceanic sun glint. A comparison of the GOME-2A/B OCRA cloud fractions with colocated AVHRR (Advanced Very High Resolution Radiometer) geometrical cloud fractions shows a general good agreement with a mean difference of -0.15 ± 0.20. From an operational point of view, an advantage of the OCRA algorithm is its very fast computational time and its straightforward transferability to similar sensors like OMI (Ozone Monitoring Instrument), TROPOMI (TROPOspheric Monitoring Instrument) on Sentinel 5 Precursor, as well as Sentinel 4 and Sentinel 5. In conclusion, it is shown that a robust, accurate and fast radiometric cloud-fraction estimation for GOME-2 can be achieved with OCRA using polarization measurement devices (PMDs).

  14. Round Robin evaluation of soil moisture retrieval models for the MetOp-A ASCAT Instrument

    NASA Astrophysics Data System (ADS)

    Gruber, Alexander; Paloscia, Simonetta; Santi, Emanuele; Notarnicola, Claudia; Pasolli, Luca; Smolander, Tuomo; Pulliainen, Jouni; Mittelbach, Heidi; Dorigo, Wouter; Wagner, Wolfgang

    2014-05-01

    Global soil moisture observations are crucial to understand hydrologic processes, earth-atmosphere interactions and climate variability. ESA's Climate Change Initiative (CCI) project aims to create a global consistent long-term soil moisture data set based on the merging of the best available active and passive satellite-based microwave sensors and retrieval algorithms. Within the CCI, a Round Robin evaluation of existing retrieval algorithms for both active and passive instruments was carried out. In this study we present the comparison of five different retrieval algorithms covering three different modelling principles applied to active MetOp-A ASCAT L1 backscatter data. These models include statistical models (Bayesian Regression and Support Vector Regression, provided by the Institute for Applied Remote Sensing, Eurac Research Viale Druso, Italy, and an Artificial Neural Network, provided by the Institute of Applied Physics, CNR-IFAC, Italy), a semi-empirical model (provided by the Finnish Meteorological Institute), and a change detection model (provided by the Vienna University of Technology). The algorithms were applied on L1 backscatter data within the period of 2007-2011, resampled to a 12.5 km grid. The evaluation was performed over 75 globally distributed, quality controlled in situ stations drawn from the International Soil Moisture Network (ISMN) using surface soil moisture data from the Global Land Data Assimilation System (GLDAS-) Noah land surface model as second independent reference. The temporal correlation between the data sets was analyzed and random errors of the the different algorithms were estimated using the triple collocation method. Absolute soil moisture values as well as soil moisture anomalies were considered including both long-term anomalies from the mean seasonal cycle and short-term anomalies from a five weeks moving average window. Results show a very high agreement between all five algorithms for most stations. A slight

  15. Remote OP-FTIR sensing of magmatic gases driving Yasur trachyandesitic explosive activity, Vanuatu island arc

    NASA Astrophysics Data System (ADS)

    Allard, P.; Burton, M.; Sawyer, G.

    2012-04-01

    Yasur volcano, located in the southern part of the Vanuatu island arc (Tanna island), is a small trachyandesitic cone that has grown in the resurgent (17 cm y-1) Siwi caldera. Since about 1,400 years Yasur has displayed almost continuous Strombolian-Vulcanian explosive activity and is one of the most actively erupting volcanoes worldwide. Using open-path Fourier transform infrared (OP-FTIR) spectroscopy from the crater rim (260-300 m slanting distance) and molten lava as the radiation source, we measured during several days the high frequency compositional variations of magmatic gases driving this explosive activity. Our results expand previous observations from a first FTIR measurement in 2005 [1] and complement in-situ gas measurements made in 2007 [2] within our same research framework (French ANR 'VOLGASPEC' project). FTIR absorption spectra allowed simultaneous retrieval of the molar path amounts of volcanic H2O, CO2, SO2, HCl and CO, corrected for air background in case of H2O, CO2 and CO. We observe a rather steady composition of the crater gas release between the explosions (~one every 1-3 mn) and sharp compositional variations (increases of SO2/HCl, CO2/SO2 and CO/CO2 ratios, decrease of H2O/SO2) associated with the explosions, which demonstrate the ascent and bursting of deeper-derived, CO2-SO2-CO-enriched gas slugs. Such abrupt compositional changes of magmatic gases driving explosive activity at Yasur do resemble those recorded at Stromboli volcano [3]. However, in contrast to Stromboli, Yasur explosions generate dense ash clouds whose fast expansion significantly affects the measured column gas amounts at the onset of each event (an effect considered in our data elaboration). When referred to the pressure-related behaviour of dissolved volatiles in the trachyandesitic magma feeding Yasur (melt inclusions [2]), our results provide new constraints on the source depth(s) of the explosions and the magma degassing processes controlling the volcanic activity

  16. Recent SO2 camera and OP-FTIR field measurements in Mexico and Guatemala

    NASA Astrophysics Data System (ADS)

    La Spina, Alessandro; Salerno, Giuseppe; Burton, Michael

    2013-04-01

    Between 22 and 30 November 2012 a field campaign was carried out at Mexico and Guatemala with the objectives of state the volcanic gas composition and flux fingerprints of Popocatepetl, Santiaguito, Fuego and Pacaya by exploiting simultaneously UV-camera and FTIR measurements. Gases were measured remotely using instruments sensitive to ultraviolet and infrared radiation (UV spectrometer, SO2-camera and OP-FTIR). Data collection depended on the requirements of the methodology, weather condition and eruptive stage of the volcanoes. OP-FTIR measurements were carried out using the MIDAC interferometer with 0.5 cm-1 resolution. Spectra were collected in solar occultation mode in which the Sun acts as an infrared source and the volcanic plume is interposed between the Sun and the spectrometer. At Santiaguito spectra were also collected in passive mode using the lava flow as a radiation source. The SO2-camera used for this study was a dual camera system consisting of two QS Imaging 640s cameras. Each of the two cameras was outfitted with two quartz 25mm lens, coupled with two band-pass filters centred at 310nm and at 330nm. The imaging system was managed by a custom-made software developed in LabView. The UV-camera system was coupled with a USB2000+ spectrometer connected to a QP1000-2-SR 1000 micron optical fiber with a 74-UV collimating lens. For calibration of plume imagery, images of five quartz cells containing known concentration path-lengths of SO2 were taken at the end of each sampling. Between 22 and 23 November 2012 UV-camera and FTIR observations were carried out at Popocatepetl. During the time of our observation, the volcano was characterised by pulsing degassing from the summit crater forming a whitish plume that dispersed rapidly in the atmosphere according to wind direction and speed. Data were collected from the Observatorio Atmosférico Altzomoni (Universidad Nacional Autónoma de México) at 4000 metre a.s.l. and at a distance of ~12 km from the volcano

  17. Advanced Technologies for Robotic Exploration Leading to Human Exploration: Results from the SpaceOps 2015 Workshop

    NASA Technical Reports Server (NTRS)

    Lupisella, Mark L.; Mueller, Thomas

    2016-01-01

    This paper will provide a summary and analysis of the SpaceOps 2015 Workshop all-day session on "Advanced Technologies for Robotic Exploration, Leading to Human Exploration", held at Fucino Space Center, Italy on June 12th, 2015. The session was primarily intended to explore how robotic missions and robotics technologies more generally can help lead to human exploration missions. The session included a wide range of presentations that were roughly grouped into (1) broader background, conceptual, and high-level operations concepts presentations such as the International Space Exploration Coordination Group Roadmap, followed by (2) more detailed narrower presentations such as rover autonomy and communications. The broader presentations helped to provide context and specific technical hooks, and helped lay a foundation for the narrower presentations on more specific challenges and technologies, as well as for the discussion that followed. The discussion that followed the presentations touched on key questions, themes, actions and potential international collaboration opportunities. Some of the themes that were touched on were (1) multi-agent systems, (2) decentralized command and control, (3) autonomy, (4) low-latency teleoperations, (5) science operations, (6) communications, (7) technology pull vs. technology push, and (8) the roles and challenges of operations in early human architecture and mission concept formulation. A number of potential action items resulted from the workshop session, including: (1) using CCSDS as a further collaboration mechanism for human mission operations, (2) making further contact with subject matter experts, (3) initiating informal collaborative efforts to allow for rapid and efficient implementation, and (4) exploring how SpaceOps can support collaboration and information exchange with human exploration efforts. This paper will summarize the session and provide an overview of the above subjects as they emerged from the SpaceOps 2015

  18. Infrared detector circuits using monolithic CMOS Op-Amps with InSb detectors in a transimpedance configuration

    NASA Astrophysics Data System (ADS)

    Smith, David S.

    1992-09-01

    As the emphasis in infrared detector research shifts toward larger and more complicated arrays the amount of time spent on simple single-element and small arrays is decreasing. One set of applications where discrete detectors and arrays are still finding use is in satellites. In addition, scanned imaging arrays based on single element detectors and small arrays are still being manufactured. Discussion here is for small arrays and single element detectors. One of the aspects of detector operation that always needs to be addressed is amplification. Often detectors are attached to amplifiers through rather long leads. Such systems are subject to unwanted microphonic response as a result of the motion of the leads relative to each other or to the ground plane. This sort of microphonic response can many times be eliminated through careful wiring and routing techniques, however, in some severe environments it is not possible to eliminate all microphonic response. A commonly used solution to this problem is to hybridize the detector with a JFET front end to reduce the effective output resistance of the detector circuit relative to the amplifier input. The TIA in such configurations is completed off the focal plane at room temperature. This means that half the circuit is operating at cryogenic temperatures while the other part is operating at room temperature some distance away. Ideally it would be more convenient, if not better, to include the amplifier on the focal plane with the detector. (Of course this hybridization is necessary for large two-dimensional arrays.) Data have been acquired to show some of the limitations and opportunities for such an approach. Typical bipolar operational amplifiers (OP-27, OP-37, LM108) will not operate well at cryogenic temperatures. CMOS operational amplifiers generally will operate at cryogenic temperatures but suffer from high front-end voltage noise. The TLC2201 from Texas Instruments is a CMOS op-amp manufactured for low voltage

  19. Physiology and phylogeny of the candidate phylum "Atribacteria" (formerly OP9/JS1) inferred from single-cell genomics and metagenomics

    NASA Astrophysics Data System (ADS)

    Dodsworth, J. A.; Murugapiran, S.; Blainey, P. C.; Nobu, M.; Rinke, C.; Schwientek, P.; Gies, E.; Webster, G.; Kille, P.; Weightman, A.; Liu, W. T.; Hallam, S.; Tsiamis, G.; Swingley, W.; Ross, C.; Tringe, S. G.; Chain, P. S.; Scholz, M. B.; Lo, C. C.; Raymond, J.; Quake, S. R.; Woyke, T.; Hedlund, B. P.

    2014-12-01

    Single-cell sequencing and metagenomics have extended the genomics revolution to yet-uncultivated microorganisms and provided insights into the coding potential of this so-called "microbial dark matter", including microbes belonging candidate phyla with no cultivated representatives. As more datasets emerge, comparison of individual genomes from different lineages and habitats can provide insight into the phylogeny, conserved features, and potential metabolic diversity of candidate phyla. The candidate bacterial phylum OP9 was originally found in Obsidian Pool, Yellowstone National Park, and it has since been detected in geothermal springs, petroleum reservoirs, and engineered thermal environments worldwide. JS1, another uncultivated bacterial lineage affiliated with OP9, is often abundant in marine sediments associated with methane hydrates, hydrocarbon seeps, and on continental margins and shelves, and is found in other non-thermal marine and subsurface environments. The phylogenetic relationship between OP9, JS1, and other Bacteria has not been fully resolved, and to date no axenic cultures from these lineages have been reported. Recently, 31 single amplified genomes (SAGs) from six distinct OP9 and JS1 lineages have been obtained using flow cytometric and microfluidic techniques. These SAGs were used to inform metagenome binning techniques that identified OP9/JS1 sequences in several metagenomes, extending genomic coverage in three of the OP9 and JS1 lineages. Phylogenomic analyses of these SAG and metagenome bin datasets suggest that OP9 and JS1 constitute a single, deeply branching phylum, for which the name "Atribacteria" has recently been proposed. Overall, members of the "Atribacteria" are predicted to be heterotrophic anaerobes without the capacity for respiration, with some lineages potentially specializing in secondary fermentation of organic acids. A set of signature "Atribacteria" genes was tentatively identified, including components of a bacterial

  20. Analysis of the Ship Ops Model’s Accuracy in Predicting U.S. Naval Ship Operating Cost

    DTIC Science & Technology

    2003-06-01

    AGENCY REPORT NUMBER 11. SUPPLEMENTARY NOTES The views expressed in this report are those of the author(s) and do not reflect the official policy or...Dean Graduate School of Business and Public Policy iv THIS PAGE INTENTIONALLY LEFT BLANK v ANALYSIS OF THE SHIP OPS MODEL’S ACCURACY...of Model Accuracy using backcast : 1997-2002 Year SF SU SR SO Total 1997 $24,654 $4,315 $12,748 $6,626 $48,343 1998 $29,890 $5,853 $15,300 $9,046

  1. DNA Microarray and Gene Ontology Enrichment Analysis Reveals That a Mutation in opsX Affects Virulence and Chemotaxis in Xanthomonas oryzae pv. oryzae.

    PubMed

    Kim, Hong-Il; Park, Young-Jin

    2016-06-01

    Xanthomonas oryzae pv. oryzae (Xoo) causes bacterial leaf blight (BLB) in rice (Oryza sativa L.). In this study, we investigated the effect of a mutation in opsX (XOO1056), which encodes a saccharide biosynthesis regulatory protein, on the virulence and bacterial chemotaxis of Xoo. We performed DNA microarray analysis, which showed that 63 of 2,678 genes, including genes related to bacterial motility (flagellar and chemotaxis proteins) were significantly downregulated (<-2 log2 fold changes) by the mutation in opsX. Indeed, motility assays showed that the mutant strain was nonmotile on semisolid agar swarm plates. In addition, a mutant strain (opsX::Tn5) showed decreased virulence against the susceptible rice cultivar, IR24. Quantitative real-time RT-PCR reaction was performed to confirm the expression levels of these genes, including those related to flagella and chemotaxis, in the opsX mutant. Our findings revealed that mutation of opsX affects both virulence and bacterial motility. These results will help to improve our understanding of Xoo and provide insight into Xoo-rice interactions.

  2. High frequency characteristic of a monolithic 500 °C OpAmp-RC integrator in SiC bipolar IC technology

    NASA Astrophysics Data System (ADS)

    Tian, Ye; Zetterling, Carl-Mikael

    2017-09-01

    This paper presents a comprehensive investigation of the frequency response of a monolithic OpAmp-RC integrator implemented in a 4H-SiC bipolar IC technology. The circuits and devices have been measured and characterized from 27 to 500 °C. The devices have been modelled to identify that the substrate capacitance is a dominant factor affecting the OpAmp's high-frequency response. Large Miller compensation capacitors of more than 540 pF are required to ensure stability of the internal OpAmp. The measured unit-gain-bandwidth product of the OpAmp is ∼1.1 MHz at 27 °C, and decreases to ∼0.5 MHz at 500 °C mainly due to the reduction of the transistor's current gain. On the other hand, it is not necessary to compensate the integrator in a relatively wide bandwidth ∼0.7 MHz over the investigated temperature range. At higher frequencies, the integrator's frequency response has been identified to be significantly affected by that of the OpAmp and load impedance. This work demonstrates the potential of this technology for high temperature applications requiring bandwidths of several megahertz.

  3. Reference materials and representative test materials to develop nanoparticle characterization methods: the NanoChOp project case.

    PubMed

    Roebben, Gert; Kestens, Vikram; Varga, Zoltan; Charoud-Got, Jean; Ramaye, Yannic; Gollwitzer, Christian; Bartczak, Dorota; Geißler, Daniel; Noble, James; Mazoua, Stephane; Meeus, Nele; Corbisier, Philippe; Palmai, Marcell; Mihály, Judith; Krumrey, Michael; Davies, Julie; Resch-Genger, Ute; Kumarswami, Neelam; Minelli, Caterina; Sikora, Aneta; Goenaga-Infante, Heidi

    2015-01-01

    This paper describes the production and characteristics of the nanoparticle test materials prepared for common use in the collaborative research project NanoChOp (Chemical and optical characterization of nanomaterials in biological systems), in casu suspensions of silica nanoparticles and CdSe/CdS/ZnS quantum dots (QDs). This paper is the first to illustrate how to assess whether nanoparticle test materials meet the requirements of a "reference material" (ISO Guide 30, 2015) or rather those of the recently defined category of "representative test material (RTM)" (ISO/TS 16195, 2013). The NanoChOp test materials were investigated with small-angle X-ray scattering (SAXS), dynamic light scattering (DLS), and centrifugal liquid sedimentation (CLS) to establish whether they complied with the required monomodal particle size distribution. The presence of impurities, aggregates, agglomerates, and viable microorganisms in the suspensions was investigated with DLS, CLS, optical and electron microscopy and via plating on nutrient agar. Suitability of surface functionalization was investigated with attenuated total reflection Fourier transform infrared spectrometry (ATR-FTIR) and via the capacity of the nanoparticles to be fluorescently labeled or to bind antibodies. Between-unit homogeneity and stability were investigated in terms of particle size and zeta potential. This paper shows that only based on the outcome of a detailed characterization process one can raise the status of a test material to RTM or reference material, and how this status depends on its intended use.

  4. Extending the Satellite Data Record of Tropospheric Ozone Profiles from Aura-TES to MetOp-IASI

    NASA Astrophysics Data System (ADS)

    Oetjen, H.; Payne, V.; Kulawik, S. S.; Neu, J. L.; Eldering, A.; Worden, J.; Edwards, D. P.; Francis, G. L.; Worden, H. M.

    2014-12-01

    Ozone is the third most important anthropogenic greenhouse gas and a significant pollutant at the surface affecting human and plant health. Rapidly increasing Asian emissions of ozone precursors, land-surface changes from burning, and decreasing surface emissions in Europe and North America have resulted in unknown changes to the distribution of tropospheric ozone. Satellite-borne instruments provide the means for global and continuous monitoring of this important trace gas. High spectral resolution infrared radiance measurements, such as those from the Tropospheric Emission Spectrometer (TES) on the NASA Aura satellite (launched in 2004), and the Infrared Atmospheric Sounding Instruments (IASI), on the MetOp-A and MetOp-B satellites (launched in 2006 and 2012 respectively) can be used to derive vertical information of tropospheric ozone. As part of efforts to assess consistency between the TES and IASI data records, a retrieval for ozone from IASI radiances, building on the data processor for TES, has been developed as a collaboration between NASA JPL and NCAR. Using a priori information consistent with TES retrievals, the optimal estimation approach is applied to IASI radiances in order to obtain vertical distributions of ozone. This presentation shows the characterization of these IASI ozone retrievals with respect to the vertical distribution of the uncertainties and sensitivities as well as comparisons with TES. Further, trends in ozone over Asia, North America, and Europe as seen by TES and IASI are presented.

  5. Productivity Performance of the CoOP-WEST Upwelling Region off Bodega Bay, CA: Comparison With Other Coastal Upwelling Systems.

    NASA Astrophysics Data System (ADS)

    Hogue, V.; Dugdale, R. C.; Marchi, A.; Lassiter, A.; Wilkerson, F.

    2002-12-01

    The incorporation of upwelled nutrients into phytoplankton by new production offers a means to compare the relative performance of upwelling regions in converting available nitrogen to biomass. The shift-up model of upwelling new production has been used to compare the maximum productivity rates and biomass accumulation of a set of well-studied coastal upwelling systems and evaluate their realization for new production. During the NSF funded CoOP WEST study, we measured new production using N-15 labeled nitrate uptake by different size-fractions of the phytoplankton, along with nutrients and biomass concentrations. The data collected during the CoOP WEST "upwelling-favorable" cruises in spring/summer 2000, 2001 and 2002 allow a comparison of production during different upwelling nutrient conditions within a single system, and to other previously studied systems. The fate of new production and its performance off northern California is compared with the coastal upwelling locations of Point Conception, California; Monterey Bay, California; Cap Blanc, northwest Africa and 15°S, Peru.

  6. Reference materials and representative test materials to develop nanoparticle characterization methods: the NanoChOp project case

    NASA Astrophysics Data System (ADS)

    Roebben, Gert; Kestens, Vikram; Varga, Zoltan; Charoud-Got, Jean; Ramaye, Yannic; Gollwitzer, Christian; Bartczak, Dorota; Geißler, Daniel; Noble, James; Mazoua, Stéphane; Meeus, Nele; Corbisier, Philippe; Palmai, Marcell; Mihály, Judith; Krumrey, Michael; Davies, Julie; Resch-Genger, Ute; Kumarswami, Neelam; Minelli, Caterina; Sikora, Aneta; Goenaga-Infante, Heidi

    2015-10-01

    This paper describes the production and characteristics of the nanoparticle test materials prepared for common use in the collaborative research project NanoChOp (Chemical and optical characterisation of nanomaterials in biological systems), in casu suspensions of silica nanoparticles and CdSe/CdS/ZnS quantum dots. This paper is the first to illustrate how to assess whether nanoparticle test materials meet the requirements of a 'reference material' (ISO Guide 30:2015) or rather those of the recently defined category of 'representative test material' (ISO TS 16195:2013). The NanoChOp test materials were investigated with small-angle X-ray scattering (SAXS), dynamic light scattering (DLS) and centrifugal liquid sedimentation (CLS) to establish whether they complied with the required monomodal particle size distribution. The presence of impurities, aggregates, agglomerates and viable microorganisms in the suspensions was investigated with DLS, CLS, optical and electron microscopy and via plating on nutrient agar. Suitability of surface functionalization was investigated with attenuated total reflection Fourier transform infrared spectrometry (ATR-FTIR) and via the capacity of the nanoparticles to be fluorescently labeled or to bind antibodies. Between-unit homogeneity and stability were investigated in terms of particle size and zeta potential. This paper shows that only based on the outcome of a detailed characterization process one can raise the status of a test material to representative test material or reference material, and how this status depends on its intended use.

  7. Implementation of an integrated op-amp based chaotic neuron model and observation of its chaotic dynamics

    SciTech Connect

    Jung, Jinwoo; Lee, Jewon; Song, Hanjung

    2011-03-15

    This paper presents a fully integrated circuit implementation of an operational amplifier (op-amp) based chaotic neuron model with a bipolar output function, experimental measurements, and analyses of its chaotic behavior. The proposed chaotic neuron model integrated circuit consists of several op-amps, sample and hold circuits, a nonlinear function block for chaotic signal generation, a clock generator, a nonlinear output function, etc. Based on the HSPICE (circuit program) simulation results, approximated empirical equations for analyses were formulated. Then, the chaotic dynamical responses such as bifurcation diagrams, time series, and Lyapunov exponent were calculated using these empirical equations. In addition, we performed simulations about two chaotic neuron systems with four synapses to confirm neural network connections and got normal behavior of the chaotic neuron such as internal state bifurcation diagram according to the synaptic weight variation. The proposed circuit was fabricated using a 0.8-{mu}m single poly complementary metal-oxide semiconductor technology. Measurements of the fabricated single chaotic neuron with {+-}2.5 V power supplies and a 10 kHz sampling clock frequency were carried out and compared with the simulated results.

  8. Implementation of an integrated op-amp based chaotic neuron model and observation of its chaotic dynamics.

    PubMed

    Jung, Jinwoo; Lee, Jewon; Song, Hanjung

    2011-03-01

    This paper presents a fully integrated circuit implementation of an operational amplifier (op-amp) based chaotic neuron model with a bipolar output function, experimental measurements, and analyses of its chaotic behavior. The proposed chaotic neuron model integrated circuit consists of several op-amps, sample and hold circuits, a nonlinear function block for chaotic signal generation, a clock generator, a nonlinear output function, etc. Based on the HSPICE (circuit program) simulation results, approximated empirical equations for analyses were formulated. Then, the chaotic dynamical responses such as bifurcation diagrams, time series, and Lyapunov exponent were calculated using these empirical equations. In addition, we performed simulations about two chaotic neuron systems with four synapses to confirm neural network connections and got normal behavior of the chaotic neuron such as internal state bifurcation diagram according to the synaptic weight variation. The proposed circuit was fabricated using a 0.8-μm single poly complementary metal-oxide semiconductor technology. Measurements of the fabricated single chaotic neuron with ± 2.5 V power supplies and a 10 kHz sampling clock frequency were carried out and compared with the simulated results.

  9. Reference materials and representative test materials to develop nanoparticle characterization methods: the NanoChOp project case

    PubMed Central

    Roebben, Gert; Kestens, Vikram; Varga, Zoltan; Charoud-Got, Jean; Ramaye, Yannic; Gollwitzer, Christian; Bartczak, Dorota; Geißler, Daniel; Noble, James; Mazoua, Stephane; Meeus, Nele; Corbisier, Philippe; Palmai, Marcell; Mihály, Judith; Krumrey, Michael; Davies, Julie; Resch-Genger, Ute; Kumarswami, Neelam; Minelli, Caterina; Sikora, Aneta; Goenaga-Infante, Heidi

    2015-01-01

    This paper describes the production and characteristics of the nanoparticle test materials prepared for common use in the collaborative research project NanoChOp (Chemical and optical characterization of nanomaterials in biological systems), in casu suspensions of silica nanoparticles and CdSe/CdS/ZnS quantum dots (QDs). This paper is the first to illustrate how to assess whether nanoparticle test materials meet the requirements of a “reference material” (ISO Guide 30, 2015) or rather those of the recently defined category of “representative test material (RTM)” (ISO/TS 16195, 2013). The NanoChOp test materials were investigated with small-angle X-ray scattering (SAXS), dynamic light scattering (DLS), and centrifugal liquid sedimentation (CLS) to establish whether they complied with the required monomodal particle size distribution. The presence of impurities, aggregates, agglomerates, and viable microorganisms in the suspensions was investigated with DLS, CLS, optical and electron microscopy and via plating on nutrient agar. Suitability of surface functionalization was investigated with attenuated total reflection Fourier transform infrared spectrometry (ATR-FTIR) and via the capacity of the nanoparticles to be fluorescently labeled or to bind antibodies. Between-unit homogeneity and stability were investigated in terms of particle size and zeta potential. This paper shows that only based on the outcome of a detailed characterization process one can raise the status of a test material to RTM or reference material, and how this status depends on its intended use. PMID:26539428

  10. Rural cooperatives could spark a new electricity crisis: federal bailout funds might run short if co-ops begin to fail

    SciTech Connect

    Not Available

    1984-11-19

    The Rural Electrification Administration (REA) may have to bail out many of the 981 non-profit rural electric cooperatives, which are feeling the same pinch of lower demand and high construction costs as investor-owned utilities. Neither government nor industry spokesmen will say just how large the REA's liability could be if a string of co-ops starts to fail, but more than $20 billion of the REA's $50.8 billion in loans and guarantees has gone to 16 co-ops building nuclear plants and to 11 building coal plants. The co-op industry predicts the REA will have to go to Congress for a bailout within three years. The industry's solution is for Congress to forgive nearly $8 billion in long-term debt that REA owes the Treasury.

  11. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-n-Octyl Phthalate (DnOP).

    PubMed

    2003-05-01

    The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) conducted an evaluation of the potential for di-n-octyl phthalate (DnOP) to cause adverse effects on reproduction and development in humans. DnOP is one of 7 phthalate chemicals evaluated by the NTP CERHR Phthalates Expert Panel. These phthalates were selected for evaluation because of high production volume, extent of human exposures, use in children's products, and/or published evidence of repro- ductive or developmental toxicity. Available information indicates that there are no commercial uses of pure DnOP. However, DnOP comprises approximately 20% of the commercially important C6-10 phthalate mixture, which is used in flooring and carpet tiles, tarps, pool liners, and garden hoses. DnOP is approved by the FDA as an indirect food additive and is used in seam cements, bottle cap liners, and conveyor belts. The results of this evaluation on DnOP are published in an NTP-CERHR monograph which includes: 1) the NTP Brief, 2) the Expert Panel Report on the Reproductive and Developmental Toxicity of DnOP, and 3) public comments received on the Expert Panel Report. As stated in the NTP Brief, the NTP reached the following conclusions regarding the possible effects of exposure to DnOP on human development and reproduction. Limited studies in mice and rats show that high exposures to DnOP may cause adverse developmental effects, but no evidence of reproductive effects was observed. In a continuous breeding study, no adverse effects were observed in the treated parents or their offspring after dosed feed exposure of mice (approx. 1,800, 3,600, or 7,500 mg/kg body weight/day). Human exposure information for DnOP was not available but it was assumed that the general US population would be exposed to 3-30 mug/kg body weight/day, based upon the range of estimated exposures for DEHP. Based on this assumption, NTP concluded that there is negligible concern for effects on adult

  12. 2-ammonio-6-(3-oxidopyridinium-1-yl)hexanoate (OP-lysine) is a newly identified advanced glycation end product in cataractous and aged human lenses.

    PubMed

    Argirov, Ognyan K; Lin, Bin; Ortwerth, Beryl J

    2004-02-20

    Post-translational modifications of proteins take place during the aging of human lens. The present study describes a newly isolated glycation product of lysine, which was found in the human lens. Cataractous and aged human lenses were hydrolyzed and fractionated using reverse-phase and ion-exchange high performance liquid chromatography (HPLC). One of the nonproteinogenic amino acid components of the hydrolysates was identified as a 3-hydroxypyridinium derivative of lysine, 2-ammonio-6-(3-oxidopyridinium-1-yl)hexanoate (OP-lysine). The compound was synthesized independently from 3-hydroxypyridine and methyl 2-[(tert-butoxycarbonyl)amino]-6-iodohexanoate. The spectral and chromatographic properties of the synthetic OP-lysine and the substance isolated from hydrolyzed lenses were identical. HPLC analysis showed that the amounts of OP-lysine were higher in water-insoluble compared with water-soluble proteins and was higher in a pool of cataractous lenses compared with normal aged lenses, reaching 500 pmol/mg protein. The model incubations showed that an anaerobic reaction mixture of Nalpha-tert-butoxycarbonyllysine, glycolaldehyde, and glyceraldehyde could produce the Nalpha-t-butoxycarbonyl derivative of OP-lysine. The irradiation of OP-lysine with UVA under anaerobic conditions in the presence of ascorbate led to a photochemical bleaching of this compound. Our results argue that OP-lysine is a newly identified glycation product of lysine in the lens. It is a marker of aging and pathology of the lens, and its formation could be considered as a potential cataract risk-factor based on its concentration and its photochemical properties.

  13. Silencing Op18/stathmin by RNA Interference Promotes the Sensitivity of Nasopharyngeal Carcinoma Cells to Taxol and High-Grade Differentiation of Xenografted Tumours in Nude Mice.

    PubMed

    Lin, Xuechi; Yu, Ting; Zhang, Lingxi; Chen, Sangyan; Chen, Xian; Liao, Ying; Long, Dan; Shen, Fang

    2016-12-01

    Nasopharyngeal carcinoma (NPC) is a refractory tumour, and chemotherapy is one of the primary treatment modalities. Oncoprotein 18 (Op18)/stathmin is a conserved small cytosolic phosphoprotein and highly expressed in tumours, which plays a vital role in maintaining the malignant phenotype of tumours. Taxol is a clinically widely used chemotherapeutic agent for a broad range of taxol-resistant tumours. This study showed that Op18/stathmin silencing by RNA interference (RNAi) combined taxol cooperatively improved cellular apoptosis in CNE1 cells mainly via initiating endogenous death receptor pathway, impaired the capabilities of cellular proliferation and cellular migration and down-regulated the half maximal inhibitory concentration (IC50 ) of taxol, meanwhile decreased the expression of the upstream extracellular regulated kinase 1 (ERK1) in vitro. Evidence also showed that taxol cytotoxicity was markedly augmented for Op18/stathmin RNAi in other NPC cells. In vivo animal experiments have demonstrated that early combination of Op18/stathmin silencing and taxol evidently inhibited tumourigenicity of CNE1 cells and growth of xenografted tumours in nude mice. Remarkably, silencing Op18/stathmin by RNAi still promoted transformation of late-stage CNE1 cells in NPC-xenografted tumours from moderately to highly differentiated and inhibited the pleiotropic cytokine interleukin-10 (IL-10) autocrine by transplanted tumours. These findings suggest that silencing Op18/stathmin by RNAi promotes chemosensitization of NPC to taxol and reverses malignant phenotypes of NPC, which provides a new clue for treating drug-resistant tumours. © 2016 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).

  14. Members of candidate divisions OP11, OD1 and SR1 are widespread along the water column of the meromictic Lake Pavin (France).

    PubMed

    Borrel, Guillaume; Lehours, Anne-Catherine; Bardot, Corinne; Bailly, Xavier; Fonty, Gérard

    2010-07-01

    The vertical distribution of OP11, OD1 and SR1 divisions in the oxycline and in the anoxic water column of Lake Pavin, a freshwater permanently stratified mountain lake in France, was determined by temporal temperature gel gradient electrophoresis and 16S rRNA clone libraries. Gradual changes in the community structure were noted in relation to environmental variables along the oxidized/reduced environment. In addition, a separate effort to identify members of these lineages in the oxic mixolimnion identified sequences affiliated to SR1 and OP11 divisions, indicating that they are more widespread than previously expected.

  15. Implications of protonation and substituent effects for C-O and O-P bond cleavage in phosphate monoesters.

    PubMed

    Loncke, Paul G; Berti, Paul J

    2006-05-10

    A recent study of phosphate monoesters that broke down exclusively through C-O bond cleavage and whose reactivity was unaffected by protonation of the nonbridging oxygens (Byczynski et al. J. Am. Chem. Soc. 2003, 125, 12541) raised several questions about the reactivity of phosphate monoesters, R-O-P(i). Potential catalytic strategies, particularly with regard to selectively promoting C-O or O-P bond cleavage, were investigated computationally through simple alkyl and aryl phosphate monoesters. Both C-O and O-P bonds lengthened upon protonating the bridging oxygen, R-O(H(+))-P(i), and heterolytic bond dissociation energies, DeltaH(C)(-)(O) and DeltaH(O)(-)(P), decreased. Which bond will break depends on the protonation state of the phosphoryl moiety, P(i), and the identity of the organosubstituent, R. Protonating the bridging oxygen when the nonbridging oxygens were already protonated favored C-O cleavage, while protonating the bridging oxygen of the dianion form, R-O-PO(3)(2)(-), favored O-P cleavage. Alkyl R groups capable of forming stable cations were more prone to C-O bond cleavage, with tBu > iPr > F(2)iPr > Me. The lack of effect on the C-O cleavage rate from protonating nonbridging oxygens could arise from two precisely offsetting effects: Protonating nonbridging oxygens lengthens the C-O bond, making it more reactive, but also decreases the bridging oxygen proton affinity, making it less likely to be protonated and, therefore, less reactive. The lack of effect could also arise without bridging oxygen protonation if the ratio of rate constants with different protonation states precisely matched the ratio of acidity constants, K(a). Calculations used hybrid density functional theory (B3PW91/6-31++G) methods with a conductor-like polarizable continuum model (CPCM) of solvation. Calculations on Me-phosphate using MP2/aug-cc-pVDZ and PBE0/aug-cc-pVDZ levels of theory, and variations on the solvation model, confirmed the reproducibility with different

  16. VHF SoOp (Signal of Opportunity) Technology Demonstration for Soil Moisture Measurement Using Microwave Hydraulic Boom Truck Platform

    NASA Astrophysics Data System (ADS)

    Joseph, A. T.; Deshpande, M.; Miles, L.; O'Neill, P. E.

    2016-12-01

    A goal of this research is to test deployable VHF antennas for 6U Cubesat platforms to enable validation of root zone soil moisture (RZSM) estimation algorithms for signal of opportunity (SoOp) remote sensing over the 240-270 MHz frequency band. The proposed work provides a strong foundation for establishing a technology development path for maturing a global direct surface soil moisture (SM) and RZSM measurement system over a variety of land covers. Knowledge of RZSM up to a depth of 1 meter and surface SM up to a depth of 0.05 meter on a global scale, at a spatial resolution of 1-10 km through moderate-to-heavy vegetation, is critical to understanding global water resources and the vertical moisture gradient in the Earth's surface layer which controls moisture interactions between the soil, vegetation, and atmosphere. Current observations of surface SM from space by L-band radiometers (1.4 GHz) and radars (1.26 GHz) are limited to measurements of surface SM up to a depth of 0.05 meter through moderate amounts of vegetation. This limitation is mainly due to the inability of L-band signals to penetrate through dense vegetation and deep into the soil column. Satellite observations of the surface moisture conditions are coupled to sophisticated models which extrapolate the surface SM into the root zone, thus providing an indirect estimate rather than a direct measurement of RZSM. To overcome this limitation, low-frequency airborne radars operating at 435 MHz and 118 MHz have been investigated, since these lower frequencies should penetrate denser vegetation and respond to conditions deeper in the soil. This presentation describes a new and less expensive technique for SM as well as RZSM direct measurement using Signal of Opportunity transmitters. Being less expensive and needing only passive simple RF receiver, the SoOp concept has the potential for being used for space borne applications, thus providing global SM and RZSM measurements. This study will describe

  17. VHF SoOp (Signal of Opportunity) Technology Demonstration for Soil Moisture Measurement Using Microwave Hydraulic Boom Truck Platform

    NASA Astrophysics Data System (ADS)

    Joseph, Alicia; Deshpande, Manohar; O'Neill, Peggy; Miles, Lynn

    2017-04-01

    A goal of this research is to test deployable VHF antennas for 6U Cubesat platforms to enable validation of root zone soil moisture (RZSM) estimation algorithms for signal of opportunity (SoOp) remote sensing over the 240-270 MHz frequency band. The proposed work provides a strong foundation for establishing a technology development path for maturing a global direct surface soil moisture (SM) and RZSM measurement system over a variety of land covers. Knowledge of RZSM up to a depth of 1 meter and surface SM up to a depth of 0.05 meter on a global scale, at a spatial resolution of 1-10 km through moderate-to-heavy vegetation, is critical to understanding global water resources and the vertical moisture gradient in the Earth's surface layer which controls moisture interactions between the soil, vegetation, and atmosphere. Current observations of surface SM from space by L-band radiometers (1.4 GHz) and radars (1.26 GHz) are limited to measurements of surface SM up to a depth of 0.05 meter through moderate amounts of vegetation. This limitation is mainly due to the inability of L-band signals to penetrate through dense vegetation and deep into the soil column. Satellite observations of the surface moisture conditions are coupled to sophisticated models which extrapolate the surface SM into the root zone, thus providing an indirect estimate rather than a direct measurement of RZSM. To overcome this limitation, low-frequency airborne radars operating at 435 MHz and 118 MHz have been investigated, since these lower frequencies should penetrate denser vegetation and respond to conditions deeper in the soil. This presentation describes a new and less expensive technique for SM as well as RZSM direct measurement using Signal of Opportunity transmitters. Being less expensive and needing only passive simple RF receiver, the SoOp concept has the potential for being used for space borne applications, thus providing global SM and RZSM measurements. This study will describe

  18. Neurophysiological monitoring of pharmacological manipulation in acute organophosphate (OP) poisoning. The effects of pralidoxime, magnesium sulphate and pancuronium.

    PubMed

    Singh, G; Avasthi, G; Khurana, D; Whig, J; Mahajan, R

    1998-08-01

    The neuromuscular transmission failure in acute organophosphate (OP) poisoning occurs because of the irreversible inactivation of the enzyme acetylcholinesterase located in the neuromuscular junction, and is distinguished neuroelectrophysiologically by single electrical stimulus-induced repetitive responses and either a decremental or a decrement-increment response upon high-rate repetitive nerve stimulation (RNS). Understandably, the administration of pharmacological agents with actions at different sites in the neuromuscular junction would alter the neuroelectrophysiological findings in acute OP poisoning. The effect of several pharmacological agents including pralidoxime (10 patients), magnesium sulphate (4 patients) and pancuronium (7 patients) on the neuroelectrophysiological abnormalities was studied in 21 patients with acute OP poisoning. Pralidoxime administration produced neurophysiological amelioration in 11 out of 15 occasions. In those cases where it produced a beneficial effect, pralidoxime administration was continued and its neuroelectrophysiological effects were studied daily. The efficacy of pralidoxime administration was demonstrated by neuroelectrophysiological testing for a maximum of 6 days after poisoning. Three types of neuroelectrophysiological responses to pralidoxime were noted: (i) lack of neuroelectrophysiological improvement (two patients); (ii) initial improvement with subsequent lack of improvement (two patients); and (iii) initial improvement with subsequent normalisation of neuromuscular transmission (5 patients). Normalisation of the electrodiagnostic tests and the failure of pralidoxime to ameliorate the neuromuscular transmission abnormalities were neuroelectrophysiological indications for the discontinuation of pralidoxime treatment. The administration of magnesium sulphate (MgSO4.7H2O, 4 g intravenous) resulted in a decrease in the CMAP amplitude, loss of the repetitive response and conversion of the decrement

  19. Small Cytoskeleton-Associated Molecule, Fibroblast Growth Factor Receptor 1 Oncogene Partner 2/Wound Inducible Transcript-3.0 (FGFR1OP2/wit3.0), Facilitates Fibroblast-Driven Wound Closure

    PubMed Central

    Lin, Audrey; Hokugo, Akishige; Choi, Jae; Nishimura, Ichiro

    2010-01-01

    Wounds created in the oral cavity heal rapidly and leave minimal scarring. We have examined a role of a previously isolated cDNA from oral wounds encoding wound inducible transcript-3.0 (wit3.0), also known as fibroblast growth factor receptor 1 oncogene partner 2 (FGFR1OP2). FGFR1OP2/wit3.0 was highly expressed in oral wound fibroblasts without noticeable up-regulation of α-smooth muscle actin. In silico analyses, denaturing and nondenaturing gel Western blot, and immunocytology together demonstrated that FGFR1OP2/wit3.0 were able to dimerize and oligomerize through coiled-coil structures and appeared to associate with cytoskeleton networks in oral wound fibroblasts. Overexpression of FGFR1OP2/wit3.0 increased the floating collagen gel contraction of naïve oral fibroblasts to the level of oral wound fibroblasts, which was in turn attenuated by small-interfering RNA knockdown. The FGFR1OP2/wit3.0 synthesis did not affect the expression of collagen I as well as procontractile peptides such as α-smooth muscle actin, and transforming growth factor-β1 had no effect on FGFR1OP2/wit3.0 expression. Fibroblastic cells derived from embryonic stem cells carrying FGFR1OP2/wit3.0 (+/−) mutation showed significant retardation in cell migration. Thus, we postulate that FGFR1OP2/wit3.0 may regulate cell motility and stimulate wound closure. FGFR1OP2/wit3.0 was not up-regulated during skin wound healing; however, when treated with FGFR1OP2/wit3.0 -expression vector, the skin wound closure was significantly accelerated, resulting in the limited granulation tissue formation. Our data suggest that FGFR1OP2/wit3.0 may possess a therapeutic potential for wound management. PMID:19959814

  20. High-efficiency space-based software radio architectures & algorithms (a minimum size, weight, and power TeraOps processor)

    SciTech Connect

    Dunham, Mark Edward; Baker, Zachary K; Stettler, Matthew W; Pigue, Michael J; Schmierer, Eric N; Power, John F; Graham, Paul S

    2009-01-01

    Los Alamos has recently completed the latest in a series of Reconfigurable Software Radios, which incorporates several key innovations in both hardware design and algorithms. Due to our focus on satellite applications, each design must extract the best size, weight, and power performance possible from the ensemble of Commodity Off-the-Shelf (COTS) parts available at the time of design. In this case we have achieved 1 TeraOps/second signal processing on a 1920 Megabit/second datastream, while using only 53 Watts mains power, 5.5 kg, and 3 liters. This processing capability enables very advanced algorithms such as our wideband RF compression scheme to operate remotely, allowing network bandwidth constrained applications to deliver previously unattainable performance.

  1. Overview of the CoOP experiments: Physical and chemical measurements parameterizing air-sea heat exchange

    NASA Astrophysics Data System (ADS)

    Bock, Erik John; Bearer Edson, James; Frew, Nelson M.; Hara, Tetsu; Haussecker, Horst; Jähne, Bernd; McGillis, Wade R.; McKenna, Sean P.; Nelson, Robert K.; Schimpf, Uwe; Uz, Mete

    Experiments performed in the Pacific and Atlantic Oceans in 1995 and 1997 attempted to measure the short time-scale and small spatial scale variability in the air-sea gas transfer rate. Along with these measurements, physical and chemical parameters known from previous laboratory studies to influence transfer rates were also characterized. These parameters include the atmospheric forcing, the capillary and capillary-gravity wave state, the surface chemical enrichment, and the level of near-surface turbulence. In this contribution we describe the methodologies employed for the measurement campaigns and summarize some general observations resulting from them. Other contributions from the coauthors describe in more detail the specific conclusions derived from the Coastal Ocean Processes (CoOP) field program.

  2. SpaceOps 2012 Plus 2: Social Tools to Simplify ISS Flight Control Communications and Log Keeping

    NASA Technical Reports Server (NTRS)

    Cowart, Hugh S.; Scott, David W.

    2014-01-01

    A paper written for the SpaceOps 2012 Conference (Simplify ISS Flight Control Communications and Log Keeping via Social Tools and Techniques) identified three innovative concepts for real time flight control communications tools based on social mechanisms: a) Console Log Tool (CoLT) - A log keeping application at Marshall Space Flight Center's (MSFC) Payload Operations Integration Center (POIC) that provides "anywhere" access, comment and notifications features similar to those found in Social Networking Systems (SNS), b) Cross-Log Communication via Social Techniques - A concept from Johnsson Space Center's (JSC) Mission Control Center Houston (MCC-H) that would use microblogging's @tag and #tag protocols to make information/requests visible and/or discoverable in logs owned by @Destination addressees, and c) Communications Dashboard (CommDash) - A MSFC concept for a Facebook-like interface to visually integrate and manage basic console log content, text chat streams analogous to voice loops, text chat streams dedicated to particular conversations, generic and position-specific status displays/streams, and a graphically based hailing display. CoLT was deployed operationally at nearly the same time as SpaceOps 2012, the Cross- Log Communications idea is currently waiting for a champion to carry it forward, and CommDash was approved as a NASA Iinformation Technoloby (IT) Labs project. This paper discusses lessons learned from two years of actual CoLT operations, updates CommDash prototype development status, and discusses potential for using Cross-Log Communications in both MCC-H and/or POIC environments, and considers other ways for synergizing console applcations.

  3. Lessons Learned from the Implementation of Brighter Bites: A Food Co-Op to Increase Access to Fruits and Vegetables and Nutrition Education among Low-income Children and Their Families

    ERIC Educational Resources Information Center

    Sharma, Shreela V.; Chow, Joanne; Pomeroy, Michael; Raber, Margaret; Salako, David; Markham, Christine

    2017-01-01

    Background: Food co-op models have gained popularity as a mechanism for offering affordable, quality produce. We describe the challenges, successes, and lessons learned from implementation of a school-based program using a food co-op model combined with nutrition education to improve access to and intake of fresh fruits and vegetables among…

  4. MUSICA MetOp/IASI {H2O,δD} pair retrieval simulations for validating tropospheric moisture pathways in atmospheric models

    NASA Astrophysics Data System (ADS)

    Schneider, Matthias; Borger, Christian; Wiegele, Andreas; Hase, Frank; García, Omaira E.; Sepúlveda, Eliezer; Werner, Martin

    2017-02-01

    The project MUSICA (MUlti-platform remote Sensing of Isotopologues for investigating the Cycle of Atmospheric water) has shown that the sensor IASI aboard the satellite MetOp can measure the free tropospheric {H2O,δD} pair distribution twice per day on a quasi-global scale. Such data are very promising for investigating tropospheric moisture pathways, however, the complex data characteristics compromise their usage in the context of model evaluation studies. Here we present a tool that allows for simulating MUSICA MetOp/IASI {H2O,δD} pair remote sensing data for a given model atmosphere, thereby creating model data that have the remote sensing data characteristics assimilated. This model data can then be compared to the MUSICA data. The retrieval simulation method is based on the physical principles of radiative transfer and we show that the uncertainty of the simulations is within the uncertainty of the MUSICA MetOp/IASI products, i.e. the retrieval simulations are reliable enough. We demonstrate the working principle of the simulator by applying it to ECHAM5-wiso model data. The few case studies clearly reveal the large potential of the MUSICA MetOp/IASI {H2O,δD} data pairs for evaluating modelled moisture pathways. The tool is made freely available in form of MATLAB and Python routines and can be easily connected to any atmospheric water vapour isotopologue model.

  5. Comparison of 3D-OP-OSEM and 3D-FBP reconstruction algorithms for High-Resolution Research Tomograph studies: effects of randoms estimation methods

    NASA Astrophysics Data System (ADS)

    van Velden, Floris H. P.; Kloet, Reina W.; van Berckel, Bart N. M.; Wolfensberger, Saskia P. A.; Lammertsma, Adriaan A.; Boellaard, Ronald

    2008-06-01

    The High-Resolution Research Tomograph (HRRT) is a dedicated human brain positron emission tomography (PET) scanner. Recently, a 3D filtered backprojection (3D-FBP) reconstruction method has been implemented to reduce bias in short duration frames, currently observed in 3D ordinary Poisson OSEM (3D-OP-OSEM) reconstructions. Further improvements might be expected using a new method of variance reduction on randoms (VRR) based on coincidence histograms instead of using the delayed window technique (DW) to estimate randoms. The goal of this study was to evaluate VRR in combination with 3D-OP-OSEM and 3D-FBP reconstruction techniques. To this end, several phantom studies and a human brain study were performed. For most phantom studies, 3D-OP-OSEM showed higher accuracy of observed activity concentrations with VRR than with DW. However, both positive and negative deviations in reconstructed activity concentrations and large biases of grey to white matter contrast ratio (up to 88%) were still observed as a function of scan statistics. Moreover 3D-OP-OSEM+VRR also showed bias up to 64% in clinical data, i.e. in some pharmacokinetic parameters as compared with those obtained with 3D-FBP+VRR. In the case of 3D-FBP, VRR showed similar results as DW for both phantom and clinical data, except that VRR showed a better standard deviation of 6-10%. Therefore, VRR should be used to correct for randoms in HRRT PET studies.

  6. Methods for measurement of developmental reproductive alterations in newborn and infant F1 male rats after in utero chemical exposure: OPs for measurement of AGD and NR

    EPA Science Inventory

    NR OP Abstract:The purpose of this SOP is to outline a procedure for the evaluation of the presence or absence of nipples/areola in the day 13 rodent pup. In the absence of androgens from the developing testes, female rats develop nipples/areola, while dihydrotestosterone induce...

  7. Project on Social Architecture in Education. Final Report. Part III: Case Studies. Chapter 9: Arts Co-op: An Experimental High School Program.

    ERIC Educational Resources Information Center

    Sullivan, Ellen Wahl

    This document contains chapter 9 of the final report of the Project on Social Architecture in Education. Chapter 9 is about a regional experimental high school program for the arts. Several features distinguished Arts Co-op from the other schools in the study. For one, it was a special purpose school, focused on the arts, and not offering a…

  8. Canada's Industry-University Co-Op Education Accreditation System and Its Inspiration for the Evaluation of China's Industry-University-Institute Cooperative Education

    ERIC Educational Resources Information Center

    Qiubo, Yang; Shibin, Wang; Zha, Qiang

    2016-01-01

    The high degree of interest that higher education systems around the world have in employability has driven the profound development of industry-university cooperative education. Canada's industry-university co-op education system has served as a model for global cooperative education, and its accreditation system guarantees the high quality of…

  9. Exploring inter-task transfer following a CO-OP approach with four children with DCD: A single subject multiple baseline design.

    PubMed

    Capistran, Julie; Martini, Rose

    2016-10-01

    Cognitive Orientation to daily Occupational Performance (CO-OP) approach has been shown to be effective for improving the performance of tasks worked on in therapy and the use of cognitive strategies. No study to date seems to have explored its effectiveness for improving performance of untrained tasks (inter-task transfer) in children with Developmental Coordination Disorder (DCD). This study aimed to determine whether CO-OP leads to improved performance in an untrained task. A single-subject design with multiple baselines across skills was adopted, with three replications. Four children with DCD (7-12years) received 10 sessions of CO-OP intervention where each child worked on three tasks during therapy sessions and a fourth task was identified, but not worked on, to verify inter-task transfer. Task performance was rated over four phases (baseline, intervention, post-intervention, follow-up) using the Performance Quality Rating Scale (PQRS-OD). Graphed data was statistically analyzed using a two or three standard deviation band method. Significant improvement was obtained for 11 of 12 tasks worked on during therapy and for two of the four untrained tasks. These results indicate that the effectiveness of CO-OP to improve untrained tasks in children merit further exploration. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. A potential therapeutic application of SET/I2PP2A inhibitor OP449 for canine T-cell lymphoma.

    PubMed

    Fujiwara, Nobuyuki; Kawasaki, Hideyoshi; Yabe, Ryotaro; Christensen, Dale J; Vitek, Michael P; Mizuno, Takuya; Sato, Koichi; Ohama, Takashi

    2013-01-01

    Lymphoma is one of the most common malignant tumors in canine. Chemotherapy results in a high rate of remission; however, relapse and clinical drug resistance are usually seen within a year. Protein phosphatase 2A (PP2A) acts as a tumor suppressor and plays a critical role in mammalian cell transformation. Increased protein levels of SET, endogenous PP2A inhibitor, have been reported to correlate with poor prognosis in human leukemia. Here, we test the potential therapeutic role for a SET antagonist in canine lymphoma. We observed SET protein levels increased in multiple canine lymphoma cell lines compared with primary peripheral blood cells. A novel SET antagonist OP449 increased PP2A activity and effectively killed SET high-expressing canine lymphoma cells, but not SET low-expressing cells. Caspase-3 activation and enhanced Annexin V positive staining were observed after OP449 treatment, suggesting apoptotic cell death by OP449. Consistent with this, pan-caspase inhibitor Z-VAD-FMK blocked OP449 induced cell death. These data demonstrated the potential therapeutic application of SET antagonists for canine lymphoma.

  11. Canada's Industry-University Co-Op Education Accreditation System and Its Inspiration for the Evaluation of China's Industry-University-Institute Cooperative Education

    ERIC Educational Resources Information Center

    Qiubo, Yang; Shibin, Wang; Zha, Qiang

    2016-01-01

    The high degree of interest that higher education systems around the world have in employability has driven the profound development of industry-university cooperative education. Canada's industry-university co-op education system has served as a model for global cooperative education, and its accreditation system guarantees the high quality of…

  12. Cognitive Orientation to daily Occupational Performance (CO-OP) as group therapy for children living with motor coordination difficulties: An integrated literature review.

    PubMed

    Anderson, Leanne; Wilson, Jessie; Williams, Gary

    2017-04-01

    Children with Developmental Coordination Disorder (DCD) demonstrate limited participation in daily occupations which negatively impacts their physical and psycho-social wellbeing. The CO-OP approach is strongly supported within the literature as an effective treatment for DCD when delivered as a one-on-one therapy. Group interventions have proven to be effective in increasing self-esteem, decreasing feelings of isolation and are a cost effective way of delivering therapy. The purpose of this review was to explore the evidence for the use of the CO-OP approach in a group format for children with motor coordination difficulties. Searches of CINAHL, MEDLINE, Scopus, Proquest, PsycINFO, ERIC and OTDBase, were conducted from 2000 through until September 30, 2015. Articles included were in English, peer reviewed articles, followed principals of CO-OP and were delivered through a group therapy approach. All articles were critically reviewed and thematically analysed. 192 studies were retrieved with a final number of six articles included in the review. Six themes were highlighted: achieving a new level of perceived competence; feeling a sense of belonging; children learning how the condition affected them and strategies to overcome these challenges; careful formation of intervention groups; the value of following the CO-OP protocols; and the significance of parental involvement. The findings of this review suggest that the CO-OP approach, when administered in a group format, has the potential to benefit children living with motor coordination difficulties in both physical and psycho-social domains. More research is required to confirm these findings and contribute to evidence-based practice. © 2016 Occupational Therapy Australia.

  13. The direct fitting approach for total ozone column retrievals: a sensitivity study on GOME-2/MetOp-A measurements

    NASA Astrophysics Data System (ADS)

    Wassmann, A.; Borsdorff, T.; aan de Brugh, J. M. J.; Hasekamp, O. P.; Aben, I.; Landgraf, J.

    2015-10-01

    We present a sensitivity study of the direct fitting approach to retrieve total ozone columns from the clear sky Global Ozone Monitoring Experiment 2/MetOp-A (GOME-2/MetOp-A) measurements between 325 and 335 nm in the period 2007-2010. The direct fitting of the measurement is based on adjusting the scaling of a reference ozone profile and requires accurate simulation of GOME-2 radiances. In this context, we study the effect of three aspects that introduce forward model errors if not addressed appropriately: (1) the use of a clear sky model atmosphere in the radiative transfer demanding cloud filtering, (2) different approximations of Earth's sphericity to address the influence of the solar zenith angle, and (3) the need of polarization in radiative transfer modeling. We conclude that cloud filtering using the operational GOME-2 FRESCO (Fast Retrieval Scheme for Clouds from the Oxygen A band) cloud product, which is part of level 1B data, and the use of pseudo-spherical scalar radiative transfer is fully sufficient for the purpose of this retrieval. A validation with ground-based measurements at 36 stations confirms this showing a global mean bias of -0.1 % with a standard deviation (SD) of 2.7 %. The regularization effect inherent to the profile scaling approach is thoroughly characterized by the total column averaging kernel for each individual retrieval. It characterizes the effect of the particular choice of the ozone profile to be scaled by the inversion and is part of the retrieval product. Two different interpretations of the data product are possible: first, regarding the retrieval product as an estimate of the true column, a direct comparison of the retrieved column with total ozone columns from ground-based measurements can be done. This requires accurate a priori knowledge of the reference ozone profile and the column averaging kernel is not needed. Alternatively, the retrieval product can be interpreted as an effective column defined by the total column

  14. Le POSSUM: un bon score pour prédire la mortalité du sujet âgé opéré en urgence?

    PubMed Central

    Mzoughi, Zeineb; Bayar, Rached; Djebbi, Achref; Talbi, Ghofrane; Romdhane, Hayfa; Aloui, Wafa; Lassaad, Gharbi; Khalfallah, Mohamed Taher

    2016-01-01

    Introduction Le POSSUM (Physiologic and Operative Severity Score for the enUmeration of Mortality and morbidity) est un score prédictif de mortalité qui est largement utilisé en chirurgie aortique élective et abdominale. Le but de notre étude est une validation du POSSUM chez le sujet âgé (>70 ans) opéré pour une urgence digestive. Nous nous proposons d'étudier les meilleurs seuils du POSSUM, composé d'un score physiologique et d'un score opératoire, pour prédire la mortalité dans cette population. Méthodes Il s'agit d'une étude rétrospective analytique de type cas témoin à partir d'une série de 291 patients d'âge ≥ 70 ans opérés pour une urgence digestive. Ces patients étaient répartis en deux groupes comportant 50 patients chacun. Le groupe "DC": patients décédés en post opératoire immédiat et le Groupe témoin "SURV" choisis par tirage au sort. Nous avons analysé la fiabilité du POSSUM pour prédire la mortalité et la morbidité. Par la suite, nous avons établi des courbes de ROC pour définir les seuils qui donnent le meilleur couple sensibilité/spécificité. Résultats Le score physiologique, le score opératoire et les taux de morbidité et mortalité prédits par POSSUM et la mortalité prédit par P-POSSUM représentaient des facteurs prédictifs de mortalité (P <0,0001). Les valeurs seuils du score physiologique et du score opératoire qui donnent le meilleur couple sensibilité/spécificité, étaient respectivement de 23 et 15. Conclusion Prédire la mortalité permet de cibler la prise en charge et d'informer le patient et sa famille des risques encourus. PMID:27795763

  15. Evolution post-opératoire des séquelles de tuberculose pulmonaire chez les séropositifs VIH

    PubMed Central

    Grégoire, Ayegnon Kouakou; Flavien, Kendja Hypolite; Raphaël, Ouédé; Démine, Blaise; Christophe, Ménéas Gueu; Marie, Ano Kounangui; Hervé, Yangni-Angaté Koffi; Yves, Tanauh

    2014-01-01

    Cette étude rapporte les aspects cliniques et évolutifs des séquelles pulmonaires tuberculeuses (SPT) opérées chez les séropositifs (VIH+). Il s'agit d'une étude prospective transversale réalisée entre Novembre 2005 et Octobre 2012. Elle a porté sur 20 patients VIH+, ayant dans leurs antécédents, une tuberculose pulmonaire (TP) traitée et déclarée guérie, et admise dans ladite période pour une chirurgie de la SPT secondaire. Une enquête sérologique VIH a été réalisée systématiquement au cours du bilan pré-opératoire. Le diagnostic pré-opératoire de la SPT, la mortalité, les complications post- opératoires (CPOP), le séjour hospitalier, le suivi à moyen terme des STP opérées ont été évalués. Les séropositifs étaient VIH1+ (n = 12; 60%), VIH1&2+ (n = 4; 20%) et VIH2+ (n = 4; 20%). La durée moyenne d’évolution des STP était de 26,22 ± 21,3 mois. Les STP étaient les pyothorax ou pleurésies enkystées (n = 16; 80%), le poumon détruit (n = 2;10%) et les dilatations de bronches (n = 2;10%). Les VIH+ ne présentaient pas d'aspergillome pulmonaire. Le séjour hospitalier moyen était 13,1 ± 10,2 jours. Le suivi total était de 82 patients-année avec une moyenne de suivi de 4,2 ± 2,3 ans (extrêmes: 1 et 7 ans). Le taux de mortalité à court et moyen terme était nul. Aucun décès post-opératoire immédiat n'a été noté. Les CPOP immédiates étaient les bullages prolongés chez 75% des immunodéprimés. Les CPOP tardives (n = 3) étaient un syndrome restrictif pulmonaire, un pyothorax persistant et une pachypleurite résiduelle restrictive. A court terme, le taux de guérison radiologique était de 80% (n = 16). PMID:24932331

  16. Effect of acetylcholinesterase (AChE) point-of-care testing in OP poisoning on knowledge, attitudes and practices of treating physicians in Sri Lanka

    PubMed Central

    2014-01-01

    Background Toxicology and Emergency medicine textbooks recommend measurement of acetylcholinesterase (AChE) in all symptomatic cases of organophosphorus (OP) poisoning but laboratory facilities are limited in rural Asia. The accuracy of point-of-care (POC) acetylcholinesterase testing has been demonstrated but it remains to be shown whether results would be valued by clinicians. This study aims to assess the effect of seeing AChE POC test results on the knowledge, attitudes and practices of doctors who frequently manage OP poisoning. Methods We surveyed 23 clinicians, who had different levels of exposure to seeing AChE levels in OP poisoned patients, on a) knowledge of OP poisoning and biomarker interpretation, b) attitudes towards AChE in guiding poison management, oxime therapy and discharge decisions, and c) practices of ordering AChE in poisoning scenarios. Results An overall high proportion of doctors valued the test (68-89%). However, we paradoxically found that doctors who were more experienced in seeing AChE results valued the test less. Lower proportions valued the test in guidance of acute poisoning management (50%, p = 0.015) and guidance of oxime therapy (25%, p = 0.008), and it was apparent it would not generally be used to facilitate early discharge. The highest proportion of respondents valued it on admission (p < 0.001). A lack of correlation of test results with the clinical picture, and a perception that the test was a waste of money when compared to clinical observation alone were also comments raised by some of the respondents. Greater experience with seeing AChE test results was associated with increased knowledge (p = 0.034). However, a disproportionate lack of knowledge on interpretation of biomarkers and the pharmacology of oxime therapy (12-50%) was noted, when compared with knowledge on the mechanism of OP poisoning and management (78-90%). Conclusions Our findings suggest an AChE POC test may not be valued by rural doctors. The practical

  17. "Built-In" Action/Issues Tracking and Post-Ops Analysis Tool for Realtime Console Operations

    NASA Technical Reports Server (NTRS)

    Scott, David W.

    2008-01-01

    Marshall Space Flight Center's (MSFC) Payload Operations Integration Center (POIC) for the International Space Station (ISS) uses a number of formal databases to manage and track flight plan changes, onboard and ground equipment anomalies, and other events. However, individual console positions encounter many action items and/or occurrences that don't fit neatly into the databases, and while console logs are comprehensive, manual or automated searches do not always yield consistent results. The Payload Communications Manager (PAYCOM) team, whose members speak directly with the ISS onboard crew with respect to NASA payload operations, has found a creative way to reformat a mandatory Daily Report to organize action items, standing reminders, significant events, and other comments. While the report keeps others appraised of PAYCOMs activities and issues of the moment, the format makes it easy to capture very brief summaries of the items in a "Roll Off Matrix", including start and stop dates, resolution, and possible applicability to future ops. The matrix provides accountability for all action items, gives direct insight into the issues surrounding various payloads and methods of dealing with them, yields indirect information on PAYCOM priorities and processes, and provides a roadmap that makes it easier to get back to extensive details if needed. This paper describes how the ISS PAYCOM Daily Report and Roll Off Matrix are organized, used, and inter-related to each other and the PAYCOM operations log. While the application is for a manned vehicle, the concepts could apply in a wide spectrum of operational settings.

  18. Molecular characterization of OP354-like P[8] (P[8]b subtype) human rotaviruses A species isolated in Japan.

    PubMed

    Kuzuya, Mitsutaka; Fujii, Ritsushi; Hamano, Masako; Kida, Kouji; Kanadani, Tomohisa; Nishimura, Keiko; Kishimoto, Toshio

    2012-04-01

    OP354-like P[8] (P[8]b subtype) species A rotaviruses (RVAs) were isolated first time in Japan during a RVA survey in Okayama Prefecture between 2006 and 2009. Two of 236 RVA-positive samples were identified as G1P[8]b by reverse transcription polymerase chain reaction. P[8]b strains (RVA/human-wt/JPN/OH1998/2008/G1P[8]b and RVA/human-wt/JPN/OH2024/2008/G1P[8]b) were isolated only in May, 2008 and both patients infected with P[8]b viruses lived in the same city, suggesting that the prevalence of P[8]b RVAs is limited considerably in Okayama Prefecture. Molecular analysis of four genes (VP4, VP6, VP7, and NSP4 genes) of Japanese P[8]b strains revealed that the VP4 genes of these strains were related closely to those of Southeast Asian and Indian P[8]b strains. In contrast, the VP6, VP7, and NSP4 genes of Japanese P[8]b strains were highly homologous to G1P[8]a strains prevalent in the same area. These results suggest that the Japanese P[8]b strain may be a result of reassortment events between Japanese G1P[8]a viruses and unidentified Asian viruses possessing the P[8]b VP4 gene.

  19. Air Traffic Management Technology Demonstration-1 Concept of Operations (ATD-1 ConOps), Version 2.0

    NASA Technical Reports Server (NTRS)

    Baxley, Brian T.; Johnson, William C.; Swenson, Harry N.; Robinson, John E.; Prevot, Tom; Callantine, Todd J.; Scardina, John; Greene, Michael

    2013-01-01

    This document is an update to the operations and procedures envisioned for NASA s Air Traffic Management (ATM) Technology Demonstration #1 (ATD-1). The ATD-1 Concept of Operations (ConOps) integrates three NASA technologies to achieve high throughput, fuel-efficient arrival operations into busy terminal airspace. They are Traffic Management Advisor with Terminal Metering (TMA-TM) for precise time-based schedules to the runway and points within the terminal area, Controller-Managed Spacing (CMS) decision support tools for terminal controllers to better manage aircraft delay using speed control, and Flight deck Interval Management (FIM) avionics and flight crew procedures to conduct airborne spacing operations. The ATD-1 concept provides de-conflicted and efficient operations of multiple arrival streams of aircraft, passing through multiple merge points, from top-of-descent (TOD) to the Final Approach Fix. These arrival streams are Optimized Profile Descents (OPDs) from en route altitude to the runway, using primarily speed control to maintain separation and schedule. The ATD-1 project is currently addressing the challenges of integrating the three technologies, and their implantation into an operational environment. The ATD-1 goals include increasing the throughput of high-density airports, reducing controller workload, increasing efficiency of arrival operations and the frequency of trajectory-based operations, and promoting aircraft ADS-B equipage.

  20. OP-Triplet-ELM: Identification of real and pseudo microRNA precursors using extreme learning machine with optimal features.

    PubMed

    Pian, Cong; Zhang, Jin; Chen, Yuan-Yuan; Chen, Zhi; Li, Qin; Li, Qiang; Zhang, Liang-Yun

    2016-02-01

    MicroRNAs (miRNAs) are a set of short (21-24 nt) non-coding RNAs that play significant regulatory roles in the cells. Triplet-SVM-classifier and MiPred (random forest, RF) can identify the real pre-miRNAs from other hairpin sequences with similar stem-loop (pseudo pre-miRNAs). However, the 32-dimensional local contiguous structure-sequence can induce a great information redundancy. Therefore, it is essential to develop a method to reduce the dimension of feature space. In this paper, we propose optimal features of local contiguous structure-sequences (OP-Triplet). These features can avoid the information redundancy effectively and decrease the dimension of the feature vector from 32 to 8. Meanwhile, a hybrid feature can be formed by combining minimum free energy (MFE) and structural diversity. We also introduce a neural network algorithm called extreme learning machine (ELM). The results show that the specificity ([Formula: see text])and sensitivity ([Formula: see text]) of our method are 92.4% and 91.0%, respectively. Compared with Triplet-SVM-classifier, the total accuracy (ACC) of our ELM method increases by 5%. Compared with MiPred (RF) and miRANN, the total accuracy (ACC) of our ELM method increases nearly by 2%. What is more, our method commendably reduces the dimension of the feature space and the training time.

  1. The COSMO-SkyMed ground and ILS and OPS segments upgrades for full civilian capacity exploitation

    NASA Astrophysics Data System (ADS)

    Fasano, L.; De Luca, G. F.; Cardone, M.; Loizzo, R.; Sacco, P.; Daraio, M. G.

    2015-10-01

    COSMO-SkyMed (CSK), is an Earth Observation joint program between Agenzia Spaziale Italiana (Italian Space Agency, ASI) and Italian Ministry of Defense (It-MoD). It consists of a constellation of four X Band Synthetic Aperture Radar (SAR) whose first satellite of has been launched on June 2007. Today the full constellation is fully qualified and is in an operative phase. The COSMO-SkyMed System includes 3 Segments: the Space Segment, the Ground Segment and the Integrated Logistic Support and Operations Segment (ILS and OPS) As part of a more complex re-engineering process aimed to improve the expected constellation lifetime, to fully exploit several system capabilities, to manage the obsolescence, to reduce the maintenance costs and to exploit the entire constellation capability for Civilian users a series of activities have been performed. In the next months these activities are planned to be completed and start to be operational so that it will be possible the programming, planning, acquisition, raw processing and archiving of all the images that the constellation can acquire.

  2. China’s new-age small farms and their vertical integration: agribusiness or co-ops?

    PubMed

    Huang, Philip C C

    2011-01-01

    The future of Chinese agriculture lies not with large mechanized farms but with small capital-labor dual intensifying family farms for livestock-poultry-fish raising and vegetable-fruit cultivation. Chinese food consumption patterns have been changing from the old 8:1:1 pattern of 8 parts grain, 1 part meat, and 1 part vegetables to a 4:3:3 pattern, with a corresponding transformation in agricultural structure. Small family-farming is better suited for the new-age agriculture, including organic farming, than large-scale mechanized farming, because of the intensive, incremental, and variegated hand labor involved, not readily open to economies of scale, though compatible with economies of scope. It is also better suited to the realities of severe population pressure on land. But it requires vertical integration from cultivation to processing to marketing, albeit without horizontal integration for farming. It is against such a background that co-ops have arisen spontaneously for integrating small farms with processing and marketing. The Chinese government, however, has been supporting aggressively capitalistic agribusinesses as the preferred mode of vertical integration. At present, Chinese agriculture is poised at a crossroads, with the future organizational mode for vertical integration as yet uncertain.

  3. Validity evidence for Surgical Improvement of Clinical Knowledge Ops: a novel gaming platform to assess surgical decision making.

    PubMed

    Lin, Dana T; Park, Julia; Liebert, Cara A; Lau, James N

    2015-01-01

    Current surgical education curricula focus mainly on the acquisition of technical skill rather than clinical and operative judgment. SICKO (Surgical Improvement of Clinical Knowledge Ops) is a novel gaming platform developed to address this critical need. A pilot study was performed to collect validity evidence for SICKO as an assessment for surgical decision making. Forty-nine subjects stratified into 4 levels of expertise were recruited to play SICKO. Later, players were surveyed regarding the realism of the gaming platform as well as the clinical competencies required of them while playing SICKO. Each group of increasing expertise outperformed the less experienced groups. Mean total game scores for the novice, junior resident, senior resident, and expert groups were 5,461, 8,519, 11,404, and 13,913, respectively (P = .001). Survey results revealed high scores for realism and content. SICKO holds the potential to be not only an engaging and immersive educational tool, but also a valid assessment in the armamentarium of surgical educators. Published by Elsevier Inc.

  4. Smectic-A and Hexatic-B Liquid Crystal Phases of Sanidic Alkyl-Substituted Dibenzo[fg,op]naphthacenes.

    PubMed

    Repasky, Paul J; Agra-Kooijman, Deña M; Kumar, Satyendra; Hartley, C Scott

    2016-03-17

    Despite longstanding interest in liquid crystalline compounds with simple rod- or disc-like shapes (calamitics or discotics), very few examples of the analogous board-shaped, or "sanidic", liquid crystals exist. A new series of alkyl-substituted dibenzo[fg,op]naphthacenes have been prepared by planarization of o-phenylene precursors through dehydrohalogenation. Their photophysical properties have been studied in dichloromethane. Liquid crystal phase behavior was characterized by polarized optical microscopy, differential scanning calorimetry, and X-ray diffraction. All of the compounds exhibit monotropic liquid crystal phases on cooling from the isotropic phase. The compounds with shorter alkyl (pentyl and heptyl) chains exhibit the uniaxial smectic-A phase analogous to that of simple calamitic mesogens. The compounds with longer alkyl (nonyl, undecyl, and tridecyl) chains exhibit a new smectic liquid crystal phase featuring short-range positional order with an apparent rectangular lattice in the smectic layers, that is, an orthogonal biaxial hexatic-B. The molecular arrangement in this phase likely corresponds to a distorted herringbone packing of the board-shaped structures. Further, the compound with nonyl chains exhibits an underlying smectic-B phase. DFT calculations show that the cores of the mesogens are twisted into C2-symmetric saddle-shaped geometries because of steric interactions along their rims. The liquid crystal phases and their structures are discussed in the context of the compounds' board-like shapes and intercore interactions.

  5. Pneumothorax spontané secondaire post opératoire compliquant une paralysie récurrentielle

    PubMed Central

    Joulali, Toufik; Derkaou, Ali; Shimi, Abdelkarim; Khatouf, Mohammed

    2014-01-01

    Le Pneumothorax spontané est défini par un épanchement gazeux de la grande cavité pleurale en dehors de tout traumatisme ou manipulation instrumentale. Son incidence est estimée à 28/100000 pour les hommes et 6/100000 pour les femmes. Les étiologies sont dominées par la broncho-pneumopathies chroniques et obstructives. Le tableau clinique est souvent grave d'emblé nécessitant une exsufflation à l'aiguille et/ou un drainage thoracique. Les récidives sont assez fréquentes et la mortalité reste assez élevée en comparaison avec les pneumothorax post traumatique ou les pneumothorax primaires. Nous rapportons le cas d'une patiente présentant en post opératoire un pneumothorax spontané sur un poumon métastatique et compliquant une paralysie récurrentielle. PMID:25419334

  6. Round-robin evaluation of nadir ozone profile retrievals: methodology and application to MetOp-A GOME-2

    NASA Astrophysics Data System (ADS)

    Keppens, A.; Lambert, J.-C.; Granville, J.; Miles, G.; Siddans, R.; van Peet, J. C. A.; van der A, R. J.; Hubert, D.; Verhoelst, T.; Delcloo, A.; Godin-Beekmann, S.; Kivi, R.; Stubi, R.; Zehner, C.

    2015-05-01

    A methodology for the round-robin evaluation and the geophysical validation of ozone profile data retrieved from nadir UV backscatter satellite measurements is detailed and discussed, consisting of data set content studies, information content studies, co-location studies, and comparisons with reference measurements. Within the European Space Agency's Climate Change Initiative on ozone (Ozone_cci project), the proposed round-robin procedure is applied to two nadir ozone profile data sets retrieved at the Royal Netherlands Meteorological Institute (KNMI) and the Rutherford Appleton Laboratory (RAL, United Kingdom), using their respective OPERA v1.26 and RAL v2.1 optimal estimation algorithms, from MetOp-A GOME-2 (i.e. the second generation Global Ozone Monitoring Experiment on the first Meteorological Operational Satellite) measurements taken in 2008. The ground-based comparisons use ozonesonde and lidar profiles as reference data, acquired by the Network for the Detection of Atmospheric Composition Change (NDACC), Southern Hemisphere Additional Ozonesonde programme (SHADOZ), and other stations of the World Meteorological Organisation's Global Atmosphere Watch (WMO GAW). This direct illustration highlights practical issues that inevitably emerge from discrepancies in e.g. profile representation and vertical smoothing, for which different recipes are investigated and discussed. Several approaches for information content quantification, vertical resolution estimation, and reference profile resampling are compared and applied as well. The paper concludes with compliance estimates of the two GOME-2 ozone profile data sets with user requirements from the Global Climate Observing System (GCOS) and from climate modellers.

  7. Round-robin evaluation of nadir ozone profile retrievals: methodology and application to MetOp-A GOME-2

    NASA Astrophysics Data System (ADS)

    Keppens, A.; Lambert, J.-C.; Granville, J.; Miles, G.; Siddans, R.; van Peet, J. C. A.; van der A, R. J.; Hubert, D.; Verhoelst, T.; Delcloo, A.; Godin-Beekmann, S.; Kivi, R.; Stübi, R.; Zehner, C.

    2014-11-01

    A methodology for the round-robin evaluation and geophysical validation of ozone profile data retrieved from nadir UV backscatter satellite measurements is detailed and discussed, consisting of dataset content studies, information content studies, co-location studies, and comparisons with reference measurements. Within ESA's Climate Change Initiative on ozone (Ozone_cci project), the proposed round-robin procedure is applied to two nadir ozone profile datasets retrieved at KNMI and RAL, using their respective OPERA v1.26 and RAL v2.1 optimal estimation algorithms, from MetOp-A GOME-2 measurements taken in 2008. The ground-based comparisons use ozonesonde and lidar profiles as reference data, acquired by the Network for the Detection of Atmospheric Composition Change (NDACC), Southern Hemisphere Additional Ozonesonde programme (SHADOZ), and other stations of WMO's Global Atmosphere Watch. This direct illustration highlights practical issues that inevitably emerge from discrepancies in e.g. profile representation and vertical smoothing, for which different recipes are investigated and discussed. Several approaches for information content quantification, vertical resolution estimation, and reference profile resampling are compared and applied as well. The paper concludes with compliance estimates of the two GOME-2 ozone profile datasets with user requirements from GCOS and from climate modellers.

  8. [Kurt Goldstein's understanding of amnesic aphasia and its underlying disorder - an early model of the pensée opératoire of the French psychosomatic school?].

    PubMed

    Danzer, G; Eisenblätter, A; Belz, W; Schulz, A; Klapp, B F

    2002-07-01

    Kurt Goldstein's understanding of amnesic aphasia in some regards anticipated the model of the pensée opératoire, a concept developed during the 60's and 70's by the French psychoanalytical school of psychosomatics. Goldstein interpreted amnesic aphasia within the framework of a "basic disorder". Closely following the philosopher Ernst Cassirer, Goldstein described amnesic aphasia as an expression of a general alteration following localized or generalised brain damage. Due to various historical events (world war, fascism, the holocaust) as well as developments during the 20(th) century (dominance of the English language in many areas of science), these connections were forgotten or were no longer recognised as such. Without wanting to determine the extent to which the concept of pensée opératoire possesses validity, one can interpret Goldstein's reflections on aphasia as a heretofore unreceived preliminary model of the psychosomatic concept of the French School.

  9. Development Of VHF (240-270 MHz) Antennas For SoOp (Signal Of Opportunity) Receiver For 6u Cubesat Platforms

    NASA Technical Reports Server (NTRS)

    Joseph, A. T.; Deshpande, M.; O'Neill, P. E.; Miles, L.

    2016-01-01

    The main goal of this research is to design, fabricate, and test deployable VHF antennas for 6U Cubesat platforms to enable validation of root zone soil moisture (RZSM) estimation algorithms for signal of opportunity (SoOp) remote sensing over the 240-270 MHz frequency band. The proposed work provides a strong foundation for establishing a technology development path for maturing a truly global direct surface soil moisture (SM) and RZSM measurement system (Figure 1) over a variety of land covers with limited density restrictions. In SoOp methodology, signals transmitted by already existing transmitters (known as transmitters of opportunity, in this case the Military Satellite Communication (MilSatCom) System's UHF Follow-On program) are utilized to measure properties of reflecting targets by recording reflected signals using a simple passive microwave receiver.

  10. Improvement of the high-accuracy 17O(p ,α )14N reaction-rate measurement via the Trojan Horse method for application to 17O nucleosynthesis

    NASA Astrophysics Data System (ADS)

    Sergi, M. L.; Spitaleri, C.; La Cognata, M.; Lamia, L.; Pizzone, R. G.; Rapisarda, G. G.; Tang, X. D.; Bucher, B.; Couder, M.; Davies, P.; deBoer, R.; Fang, X.; Lamm, L.; Ma, C.; Notani, M.; O'Brien, S.; Roberson, D.; Tan, W.; Wiescher, M.; Irgaziev, B.; Mukhamedzhanov, A.; Mrazek, J.; Kroha, V.

    2015-06-01

    The 17O(p ,α )14N and 17O(p ,γ )18F reactions are of paramount importance for the nucleosynthesis in a number of stellar sites, including red giants (RGs), asymptotic giant branch (AGB) stars, massive stars, and classical novae. In particular, they govern the destruction of 17O and the formation of the short-lived radioisotope 18F, which is of special interest for γ -ray astronomy. At temperatures typical of the above-mentioned astrophysical scenario, T =0.01 -0.1 GK for RG, AGB, and massive stars and T =0.1 -0.4 GK for a classical nova explosion, the 17O(p ,α )14N reaction cross section is dominated by two resonances: one at about ERc m=65 keV above the 18F proton threshold energy, corresponding to the EX=5.673 MeV level in 18F, and another one at ERc m=183 keV (EX=5.786 MeV). We report on the indirect study of the 17O(p ,α )14N reaction via the Trojan Horse method by applying the approach recently developed for extracting the strength of narrow resonance at ultralow energies. The mean value of the strengths obtained in the two measurements was calculated and compared with the direct data available in literature. This value was used as input parameter for reaction-rate determination and its comparison with the result of the direct measurement is also discussed in the light of the electron screening effect.

  11. Spatiotemporal pattern of neuronal injury induced by DFP in rats: A model for delayed neuronal cell death following acute OP intoxication

    SciTech Connect

    Li Yonggang; Lein, Pamela J.; Liu Cuimei; Bruun, Donald A.; Tewolde, Teclemichael; Ford, Gregory; Ford, Byron D.

    2011-06-15

    Organophosphate (OP) neurotoxins cause acute cholinergic toxicity and seizures resulting in delayed brain damage and persistent neurological symptoms. Testing novel strategies for protecting against delayed effects of acute OP intoxication has been hampered by the lack of appropriate animal models. In this study, we characterize the spatiotemporal pattern of cellular injury after acute intoxication with the OP diisopropylfluorophosphate (DFP). Adult male Sprague-Dawley rats received pyridostigmine (0.1 mg/kg, im) and atropine methylnitrate (20 mg/kg, im) prior to DFP (9 mg/kg, ip) administration. All DFP-treated animals exhibited moderate to severe seizures within minutes after DFP injection but survived up to 72 h. AChE activity was significantly depressed in the cortex, hippocampus, subcortical brain tissue and cerebellum at 1 h post-DFP injection and this inhibition persisted for up to 72 h. Analysis of neuronal injury by Fluoro-Jade B (FJB) labeling revealed delayed neuronal cell death in the hippocampus, cortex, amygdala and thalamus, but not the cerebellum, starting at 4 h and persisting until 72 h after DFP treatment, although temporal profiles varied between brain regions. At 24 h post-DFP injection, the pattern of FJB labeling corresponded to TUNEL staining in most brain regions, and FJB-positive cells displayed reduced NeuN immunoreactivity but were not immunopositive for astrocytic (GFAP), oligodendroglial (O4) or macrophage/microglial (ED1) markers, demonstrating that DFP causes a region-specific delayed neuronal injury mediated in part by apoptosis. These findings indicate the feasibility of this model for testing neuroprotective strategies, and provide insight regarding therapeutic windows for effective pharmacological intervention following acute OP intoxication. - Research Highlights: > DFP induced neuronal FJB labeling starting at 4-8 h after treatment > The pattern of DFP-induced FJB labeling closely corresponded to TUNEL staining > FJB

  12. Improved performance of Brucella melitensis native hapten over Brucella abortus OPS tracer on goat antibody detection by the fluorescence polarization assay.

    PubMed

    Ramírez-Pfeiffer, C; Díaz-Aparicio, E; Rodríguez-Padilla, C; Morales-Loredo, A; Alvarez-Ojeda, G; Gomez-Flores, R

    2008-06-15

    The current method for goat brucellosis diagnosis is based on the World Organization for Animal Health (OIE) using the screening card test (CT), with antigen at 8% (CT8) or 3% (CT3) of cell concentrations, and the confirmatory complement fixation test (CFT). However, these tests do not differentiate antibodies induced by vaccination from those derived from field infections by Brucella species or other bacterial agents; in places like Mexico, where the prevalence of brucellosis and the vaccination rates are high, there is a considerable percentage of false positive reactions that causes significant unnecessary slaughter of animals. Furthermore, results of the fluorescence polarization assay (FPA) using the Brucella abortus O-polysaccharide (OPS) tracer in goats are poorer than those with cattle. The present study was undertaken to investigate a tracer prepared from the native hapten (NH) of the Rev. 1 strain of Brucella melitensis to improve FPA performance on goat brucellosis diagnosis. Evaluation of 48 positive samples and 96 negative samples showed that the NH tracer was more accurate (p<0.01) than the OPS tracer (97.2% vs. 93.8% accuracy, respectively). On the diagnostic performance evaluation, the NH tracer performed better (87.5% accuracy, 79.5% sensitivity, 84.3% specificity, and 163.8 performance index) than the OPS tracer (83.5%, 75.9%, 81.0%, and 156.9, respectively) using 1009 positive and 2039 negative Mexican field goat sera samples selected by test series approved by the OIE (card test 3% and CFT). We demonstrated a new application for the NH lipopolysaccharide on detecting antibodies against Brucella using the FPA, which may yield faster results (minutes vs. 24-72h) than the immunodiagnosis assays frequently used in bovine brucellosis. In addition, NH tracer produces similar or better performance results than the conventional OPS tracer, using the FPA in goat sera samples.

  13. Toxicological assessment of isomeric pesticides: a strategy for testing of chiral organophosphorus (OP) compounds for delayed polyneuropathy in a regulatory setting.

    PubMed

    Battershill, Jon M; Edwards, Philippa M; Johnson, Martin K

    2004-08-01

    Many compounds, including some pesticides, contain structural centres of asymmetry, which convey the property of a type of stereoisomerism known as chirality. Such compounds can exist in two or more forms, depending on the number of chiral atoms and are termed stereoisomers or enantiomers. Stereoisomers of a particular compound can have different biological properties; one such of particular importance for toxicological evaluation, is the potential for differences in metabolic disposal of and binding of stereoisomers to molecular targets in the cell. The combination of differential metabolism of chiral organophosphorus (OP) pesticides and opposing stereoselectivity of inhibition of neuropathy target esterase (NTE) and acetylcholinesterase (AChE) can affect the value of the hen test, performed to OECD guidelines, in predicting the potential to cause organophosphate-induced delayed polyneuropathy (OPIDP) in humans. This is a mixed central and sensory and motor neuropathy. The experimental data on structural analogues of the pesticide methamidophos and the evidence for stereoselective OPIDP are reviewed and a model is given demonstrating how the properties of a chiral OP can result in the neuropathic potential not being detected by the standard hen test. A strategy for the assessment of a racemic mixture comprised of two OP enantiomers for the potential to induce OPIDP is outlined. The strategy uses information from structure activity relationships (SAR), in vitro tests and in vivo tests to allow risk assessment decisions to be made. It is suggested that the potential for stereoselective toxicity of pesticides should be routinely considered in regulatory assessments.

  14. Diagnosis and outcome of psychiatric referrals to the Field Mental Health Team, 202 Field Hospital, Op Telic I.

    PubMed

    Scott, J N

    2005-06-01

    To assess referrals to a Field Hospital Mental Health Team (FMHT), assign a diagnosis, provide appropriate treatment, and decide whether suitable for safe return to unit in theatre (RTU), or evacuation home on psychiatric grounds (evac). All documented referrals to the FMHT of 202 Field Hospital during the Op Telic 1 study period of 17 March (day 1) to 23 July 2003 (day 129) were included. Data were collected on rank, gender, diagnosis, outcome (whether RTU or evac), and whether TA before mobilisation. Diagnosis was assigned by ICD-10 criteria. The FMHT documented 170 cases, 12 of whom were seen twice and one on three occasions, resulting in 184 referrals, all of whom were British. The commonest diagnosis was adjustment reaction (F43), accounting for 68% of all cases (n = 116). These were divided between chiefly theatre-related (n = 77) or chiefly home-related (n = 39) reactions. The majority (94%) of these cases were RTU. Referrals where the diagnosis was a Depressive disorder (F32, n = 23) or Intentional self-harm (by sharp object, X78, n = 7) were evacuated. Outcome was similar for Regular and TA personnel, with on average 72% of cases RTU. The majority of cases seen were ORs, reflecting their numbers in theatre. Only 14 NCOs and 14 officers were referred. Thirteen of the latter were TA before mobilisation. Gender was not associated with outcome, or TA status, but was associated with rank, in that significantly more female officers were referred. The FMHT role tasks emerged as (a) psychiatric triage and treatment, (b) psychological support of hospital staff, and (c) welfare and pastoral care liaison. The utility of the psychiatric management model employed, built upon previous military medical doctrines, was tested in a modern theatre of conflict, and seemed to prove its worth.

  15. Chaînes opératoires and resource-exploitation strategies in chimpanzee (Pan troglodytes) nut cracking.

    PubMed

    Carvalho, Susana; Cunha, Eugénia; Sousa, Cláudia; Matsuzawa, Tetsuro

    2008-07-01

    We apply archaeological methods to extend our knowledge of chimpanzee material culture. The chaîne opératoire conceptual framework, as introduced by ethnography, established technology as a phased process. Prehistoric archaeology adopted this concept to elucidate technological variability in tool-making procedures, based on knowledge of tool functions or subsistence patterns. We focused on the detection of operational sequences by wild chimpanzees (Pan troglodytes verus) when nut cracking with lithic implements at the sites of Bossou and Diecké, Guinea, West Africa. Thus, while it has recently been claimed that chimpanzees leave behind recognizable assemblages of stone hammers that can be morphologically distinguished from Oldowan hammers, this is the first study to focus specifically on the existence of operational sequences during the utilization of stone tools by wild chimpanzees. By combining primatological and archaeological methods and examining ecological areas inhabited by different chimpanzee groups, we sought technological variability and identified variables influencing regional diversity in tool typology and technology. We compared three case studies: (1) Bossou-direct recording of experimental nut-cracking sessions; (2) Bossou- direct and indirect monitoring of nut-cracking sites in the wild; (3) Diecké-indirect monitoring of nut-cracking sites in the wild. Results suggest that chimpanzees perform sequences of repeated tool transport and nut cracking. Data show discrimination of tool functions based on tool features. We identified the most technologically complex tool for nut cracking, which was composed of four stones. We found regional diversity in chimpanzee stone assemblages. Raw-material type and tool mobility constrain technological development in human and nonhuman primates. Spatial analysis of tool distribution indicates a pattern of resource-exploitation strategy, revealing affinities with Oldowan.

  16. VHF SoOp (Signal of Opportunity) Technology Demonstration for Soil Moisture Measurement Using Microwave Hydraulic Boom Truck Platform

    NASA Technical Reports Server (NTRS)

    Joseph, A. T.; Deshpande, M.; O'Neill, P. E.; Miles, L.

    2017-01-01

    A goal of this research is to test deployable VHF antennas for 6U Cubesat platforms to enable validation of root zone soil moisture (RZSM) estimation algorithms for signal of opportunity (SoOp) remote sensing over the 240-270 MHz frequency band. The proposed work provides a strong foundation for establishing a technology development path for maturing a global direct surface soil moisture (SM) and RZSM measurement system over a variety of land covers. Knowledge of RZSM up to a depth of 1 meter and surface SM up to a depth of 0.05 meter on a global scale, at a spatial resolution of 1-10 km through moderate-to-heavy vegetation, is critical to understanding global water resources and the vertical moisture gradient in the Earths surface layer which controls moisture interactions between the soil, vegetation, and atmosphere. Current observations of surface SM from space by L-band radiometers (1.4 GHz) and radars (1.26 GHz) are limited to measurements of surface SM up to a depth of 0.05 meter through moderate amounts of vegetation. This limitation is mainly due to the inability of L-band signals to penetrate through dense vegetation and deep into the soil column. Satellite observations of the surface moisture conditions are coupled to sophisticated models which extrapolate the surface SM into the root zone, thus providing an indirect estimate rather than a direct measurement of RZSM. To overcome this limitation, low-frequency airborne radars operating at 435 MHz and 118 MHz have been investigated, since these lower frequencies should penetrate denser vegetation and respond to conditions deeper in the soil.

  17. Efficacy of using multiple open-path Fourier transform infrared (OP-FTIR) spectrometers in an odor emission episode investigation at a semiconductor manufacturing plant.

    PubMed

    Tsao, Yung-Chieh; Wu, Chang-Fu; Chang, Pao-Erh; Chen, Shin-Yu; Hwang, Yaw-Huei

    2011-08-01

    This study evaluated the efficacy of simultaneously employing three open-path Fourier transform infrared (OP-FTIR) spectrometers with 3-day consecutive monitoring, using an odor episode as an example. The corresponding monitoring paths were allocated among the possible emission sources of a semiconductor manufacturing plant and the surrounding optoelectronic and electronic-related factories, which were located in a high-tech industrial park. There was a combined total odor rate of 43.9% for the three monitoring paths, each comprised of 736 continuous 5-minute monitoring records and containing detectable odor compounds, such as ammonia, ozone, butyl acetate, and propylene glycol monomethyl ether acetate (PGMEA). The results of the logistic regression model indicated that the prevailing south wind and the OP-FTIR monitoring path closest to the emission source in down-wind direction resulted in a high efficacy for detecting odorous samples with odds ratios (OR) of 3.8 (95% confidence interval (CI): 2.9-5.0) and 5.1 (95% CI: 3.6-7.2), respectively. Meanwhile, the odds ratio for detecting ammonia odorous samples was 7.5 for Path II, which was downwind closer to the possible source, as compared to Path III, downwind far away from the possible source. PGMEA could not be monitored at Path II but could be at Path III, indicating the importance of the monitoring path and flow ejection velocities inside the stacks on the monitoring performance of OP-FTIR. Besides, an odds ratio of 5.1 for odorous sample detection was obtained with south prevailing wind comprising 65.0% of the monitoring time period. In general, it is concluded that OP-FTIR operated with multiple paths simultaneously shall be considered for investigation on relatively complicated episodes such as emergency of chemical release, multiple-source emission and chemical monitoring for odor in a densely populated plant area to enhance the efficacy of OP-FTIR monitoring. Copyright © 2011 Elsevier B.V. All rights

  18. State-of-the-Art Optical Data Collection using the Compact-Propulsion Option for Profiling Systems (C-PrOPS)

    NASA Astrophysics Data System (ADS)

    Olivier, A. L.; Hooker, S. B.; Suzuki, K.; Morrow, J. H.

    2016-02-01

    The challenges of collecting optical data in shallow waters establish state-of-the-art requirements for high temporal, spatial, and spectral resolution measurements of in situ spectral irradiance and radiance, as well as for data processing and analytical systems. Legacy profiling systems developed for the open ocean often do not properly resolve the optical complexity of shallow, near-shore waters because of their size, rate of descent, or deployment mechanics. The Compact-Propulsion Option for Profiling Systems (C-PrOPS) is an instrument system designed to obtain optical measurements in shallow waters with the documented uncertainties required for current and next generation satellite sensors, such as PACE and ACE. C-PrOPS consists of separate multichannel downward irradiance and upwelling radiance instruments mounted on a so-called hydrobaric backplane equipped with a pair of digital thrusters and a conductivity sensor. The combination of adjustable buoyancy and operator-controlled thrusters affords unprecedented maneuverability of the instruments in the water column. With a 15 Hz sampling rate, C-PrOPS can achieve 1-10 mm vertical resolution in near-surface waters. Near-surface loitering, adjustable descent rates as slow as 5 cm/s, and vertical tilts to within 2.5° during shallow (<1 m) and deep (>100 m) profiles are regularly achieved. DACPRO data acquisition software combined with PROSIT data processing provides all spectral data products (313-875 nm) within 1 m of the surface. This unprecedented spectral range allows C-PrOPS to develop and confirm the bio-optical relationships for vicarious calibration, algorithm validation, and basic research. The capability of the profiler to be maneuvered is advantageous for fragile systems that are easily damaged (coral reefs, marshes, and seagrass beds), heterogeneous systems (algal blooms), or when drought conditions result in lakes and reservoirs with impaired access. Results are presented from recent field campaigns

  19. Efficient generation of hepatic cells from multipotent adult mouse germ-line stem cells using an OP9 co-culture system.

    PubMed

    Streckfuss-Bömeke, Katrin; Jende, Jörg; Cheng, I-Fen; Hasenfuss, Gerd; Guan, Kaomei

    2014-02-01

    On the basis of their self-renewal capacity and their ability to differentiate into derivatives of all three germ layers, germ line-derived multipotent adult stem cells (maGSCs) from mouse testis might serve as one of preferable sources for pluripotent stem cells in regenerative medicine. In our study, we aimed for an efficient hepatic differentiation protocol that is applicable for both maGSCs and embryonic stem cells (ESCs). We attempted to accomplish this goal by using a new established co-culture system with OP9 stroma cells for direct differentiation of maGSCs and ESCs into hepatic cells. We found that the hepatic differentiation of maGSCs was induced by the OP9 co-culture system in comparison to the gelatin culture. Furthermore, we showed that the combination of OP9 co-culture with activin A resulted in the increased expression of endodermal and early hepatic markers Gata4, Sox17, Foxa2, Hnf4, Afp, and Ttr compared to differentiated cells on gelatin or on OP9 alone. Moreover, the hepatic progenitors were capable of differentiating further into mature hepatic cells, demonstrated by the expression of liver-specific markers Aat, Alb, Tdo2, Krt18, Krt8, Krt19, Cps1, Sek, Cyp7a1, Otc, and Pah. A high percentage of maGSC-derived hepatic progenitors (51% AFP- and 61% DLK1-positive) and mature hepatic-like cells (26% ALB-positive) were achieved using this OP9 co-culture system. These generated hepatic cells successfully demonstrated in vitro functions associated with mature hepatocytes, including albumin and urea secretion, glycogen storage, and uptake of low-density lipoprotein. The established co-culture system for maGSCs into functional hepatic cells might serve as a suitable model to delineate the differentiation process for the generation of high numbers of mature hepatocytes in humans without genetic manipulations and make germ line-derived stem cells a potential autologous and alternative cell source for hepatic transplants in metabolic liver disorders.

  20. Lesion with morphologic feature of organizing pneumonia (OP) in CT-guided lung biopsy samples for diagnosis of bronchiolitis obliterans organizing pneumonia (BOOP): a retrospective study of 134 cases in a single center

    PubMed Central

    Wang, Yongsheng; Li, Yan; Ding, Jingjing; Chen, Lulu; Dai, Jinghong; Cai, Hourong; Xiao, Yonglong; Cao, Min; Huang, Mei; Qiu, Yuying; Meng, Fanqing; Fan, Xiangshan; Zhang, Deping

    2014-01-01

    Background Small biopsy samples are generally considered inconclusive for bronchiolitis obliterans organizing pneumonia (BOOP) diagnosis despite their potential to reveal organizing pneumonia (OP) pathologically, necessitating risky invasive tissue biopsy during surgery for reliable confirmation. Objective OP by CT-guided lung biopsy was to evaluate the role in the diagnosis of BOOP. Methods A retrospective review of 134 cases with the OP feature in the CT-guided lung biopsy samples between 2004 and 2011 at a single center was conducted. Diagnostic accuracy of OP by CT-guided lung biopsy and clinical-radiographic data alone were compared. Results After exclusion of 11 cases due to pathology with others besides OP and 15 cases for loss to follow-up, 108 were included. Of these, 95 cases and 13 cases were classified as BOOP and non-BOOP group, respectively. Among BOOP group, only 30 were initially diagnosed as BOOP according to the typical clinical and radiographic features. The other 65 cases with atypical features were diagnosed as BOOP mainly based on OP by CT-guided lung biopsy. Among non-BOOP group, one was misdiagnosed as BOOP, and others were not BOOP according to clinical and radiographic findings. Thus, OP by CT-guided lung biopsy produced a diagnostic accuracy of 87.96% (95/108), much higher than 31.25% (30/96) observed using clinical and radiographic data alone. Combined, these techniques produced diagnostic accuracy of 98.96% (95/96). Conclusions OP by CT-guided lung biopsy can be effectively used as the pathological evidence for BOOP diagnosis and reducing unnecessary surgery. PMID:25276367

  1. Effects of macrophage colony-stimulating factor (M-CSF) on the development, differentiation, and maturation of marginal metallophilic macrophages and marginal zone macrophages in the spleen of osteopetrosis (op) mutant mice lacking functional M-CSF activity.

    PubMed

    Takahashi, K; Umeda, S; Shultz, L D; Hayashi, S; Nishikawa, S

    1994-05-01

    Immunohistochemical techniques using an anti-mouse panmacrophage monoclonal antibody and anti-mouse monoclonal antibodies specific for marginal metallophilic macrophages or marginal zone macrophages were used to detect red pulp macrophages, marginal metallophilic macrophages, and marginal zone macrophages in the spleen of op/op mice. In the mutant mice, the red pulp macrophages were reduced to about 60% of those in the normal littermates and the marginal metallophilic macrophages and marginal zone macrophages were absent. After administration of recombinant human macrophage colony-stimulating factor (rhM-CSF), numbers of red pulp macrophages increased rapidly, reaching levels found in normal littermates 1 week later. In contrast, the marginal metallophilic macrophages as well as the marginal zone macrophages appeared slowly after rhM-CSF administration and their numbers were less than half of the baseline level of normal littermates even at 12 weeks of administration. The distribution of marginal metallophilic macrophages and marginal zone macrophages appearing after M-CSF administration was irregular in the spleen of the op/op mice. These splenic macrophage subpopulations differed in their responses to rhM-CSF, suggesting that distinct mechanisms may be involved in their development and differentiation. The splenic red pulp macrophages present in unmanipulated op/op mice are an M-CSF-independent macrophage population. Although the marginal metallophilic macrophages and marginal zone macrophages are thought to be M-CSF-dependent, their development and differentiation appear to be influenced by locally produced M-CSF or other cytokines.

  2. SILTECH OP-40

    EPA Pesticide Factsheets

    Technical product bulletin: this surface collecting agent used in oil spill cleanups should be sprayed on water around the perimeter of an oil slick using a pressurized backpack sprayer or aerial applicator, to aid in situ burning.

  3. STS-119 Approach OPS

    NASA Image and Video Library

    2009-03-17

    ISS018-E-042056 (17 March 2009) --- Backdropped by a blue and white Earth, Space Shuttle Discovery is featured in this image photographed by an Expedition 18 crewmember as the shuttle approaches the International Space Station during STS-119 rendezvous and docking operations. Docking occurred at 4:20 p.m. (CDT) on March 17, 2009. The final pair of power-generating solar array wings and the S6 truss segment are visible in Discovery’s cargo bay. A Russian spacecraft docked to the station is visible at left.

  4. STS-119 Approach OPS

    NASA Image and Video Library

    2009-03-17

    ISS018-E-042051 (17 March 2009) --- Backdropped by a blue and white Earth, Space Shuttle Discovery is featured in this image photographed by an Expedition 18 crewmember as the shuttle approaches the International Space Station during STS-119 rendezvous and docking operations. Docking occurred at 4:20 p.m. (CDT) on March 17, 2009. The final pair of power-generating solar array wings and the S6 truss segment are visible in Discovery?s cargo bay. A Russian spacecraft docked to the station is visible at top.

  5. Commercial Crew Medical Ops

    NASA Technical Reports Server (NTRS)

    Heinbaugh, Randall; Cole, Richard

    2016-01-01

    Provide commercial partners with: center insight into NASA spaceflight medical experience center; information relative to both nominal and emergency care of the astronaut crew at landing site center; a basis for developing and sharing expertise in space medical factors associated with returning crew.

  6. PMA3 Relocate ops

    NASA Image and Video Library

    2009-08-07

    ISS020-E-028611 (7 Aug. 2009) --- European Space Agency astronaut Frank De Winne (foreground) and Canadian Space Agency astronaut Robert Thirsk, both Expedition 20 flight engineers, work the controls of the Space Station Remote Manipulator System (SSRMS) and the Centerline Berthing Camera System (CBCS) in the International Space Station’s Destiny laboratory to relocate the Pressurized Mating Adapter 3 (PMA-3) from the Unity node nadir port to Unity’s port side. This relocation is required to allow reconfigurations on the side of the Unity node port bulkhead by the crew in a pressurized environment where PMA-3 is now located. Once these reconfigurations are completed, PMA-3 will be relocated back to Unity’s nadir port, after which the Tranquility node will be brought up and berthed to Unity’s port side on mission STS-130/20A.

  7. ATV docking ops

    NASA Image and Video Library

    2014-08-12

    ISS040-E-091673 (12 Aug. 2014) --- In the Zvezda Service Module, European Space Agency astronaut Alexander Gerst (right) and Russian cosmonaut Alexander Skvortsov, both Expedition 40 flight engineers, take a brief moment for a photo during the approach and docking operations of ESA's "Georges Lemaitre" Automated Transfer Vehicle-5 (ATV-5) to the International Space Station.

  8. ATV docking ops

    NASA Image and Video Library

    2014-08-12

    ISS040-E-091688 (12 Aug. 2014) --- In the Zvezda Service Module, European Space Agency astronaut Alexander Gerst (left) and Russian cosmonaut Alexander Skvortsov, both Expedition 40 flight engineers, monitor the approach and docking of ESA?s "Georges Lemaitre" Automated Transfer Vehicle-5 (ATV-5) to the International Space Station.

  9. ATV docking ops

    NASA Image and Video Library

    2014-08-12

    ISS040-E-091635 (12 Aug. 2014) --- In the Zvezda Service Module, European Space Agency astronaut Alexander Gerst (left) and Russian cosmonaut Alexander Skvortsov, both Expedition 40 flight engineers, monitor the approach and docking of ESA's "Georges Lemaitre" Automated Transfer Vehicle-5 (ATV-5) to the International Space Station.

  10. ATV docking ops

    NASA Image and Video Library

    2014-08-12

    ISS040-E-091638 (12 Aug. 2014) --- In the Zvezda Service Module, European Space Agency astronaut Alexander Gerst (left) and Russian cosmonaut Alexander Skvortsov, both Expedition 40 flight engineers, monitor the approach and docking of ESA's "Georges Lemaitre" Automated Transfer Vehicle-5 (ATV-5) to the International Space Station.

  11. ATV docking ops

    NASA Image and Video Library

    2014-08-12

    ISS040-E-091634 (12 Aug. 2014) --- In the Zvezda Service Module, European Space Agency astronaut Alexander Gerst (left) and Russian cosmonaut Alexander Skvortsov, both Expedition 40 flight engineers, monitor the approach and docking of ESA's "Georges Lemaitre" Automated Transfer Vehicle-5 (ATV-5) to the International Space Station.

  12. CARDIOCOG. Experiment ops

    NASA Image and Video Library

    2006-11-29

    ISS014-E-08795 (29 Nov. 2006) --- European Space Agency (ESA) astronaut Thomas Reiter, Expedition 14 flight engineer, works with the Cognitive Cardiovascular (Cardiocog-2) experiment in the Zvezda Service Module of the International Space Station. Cardiocog-2 will determine the impact of weightlessness on the cardiovascular system and respiratory system and the cognitive reactions of crewmembers. The results of this study will be used to develop additional countermeasures that will continue to keep crewmembers healthy during long-duration space exploration.

  13. A statistical retrieval of cloud parameters for the millimeter wave Ice Cloud Imager on board MetOp-SG

    NASA Astrophysics Data System (ADS)

    Prigent, Catherine; Wang, Die; Aires, Filipe; Jimenez, Carlos

    2017-04-01

    The meteorological observations from satellites in the microwave domain are currently limited to below 190 GHz. However, the next generation of European Organisation for the Exploitation of Meteorological Satellites (EUMETSAT) Polar System-Second Generation-EPS-SG will carry an instrument, the Ice Cloud Imager (ICI), with frequencies up to 664 GHz, to improve the characterization of the cloud frozen phase. In this paper, a statistical retrieval of cloud parameters for ICI is developed, trained on a synthetic database derived from the coupling of a mesoscale cloud model and radiative transfer calculations. The hydrometeor profiles simulated with the Weather Research and Forecasting model (WRF) for twelve diverse European mid-latitude situations are used to simulate the brightness temperatures with the Atmospheric Radiative Transfer Simulator (ARTS) to prepare the retrieval database. The WRF+ARTS simulations have been compared to the Special Sensor Microwave Imager/Sounder (SSMIS) observations up to 190 GHz: this successful evaluation gives us confidence in the simulations at the ICI channels from 183 to 664 GHz. Statistical analyses have been performed on this simulated retrieval database, showing that it is not only physically realistic but also statistically satisfactory for retrieval purposes. A first Neural Network (NN) classifier is used to detect the cloud presence. A second NN is developed to retrieve the liquid and ice integrated cloud quantities over sea and land separately. The detection and retrieval of the hydrometeor quantities (i.e., ice, snow, graupel, rain, and liquid cloud) are performed with ICI-only, and with ICI combined with observations from the MicroWave Imager (MWI, with frequencies from 19 to 190 GHz, also on board MetOp-SG). The ICI channels have been optimized for the detection and quantification of the cloud frozen phases: adding the MWI channels improves the performance of the vertically integrated hydrometeor contents, especially for

  14. Flight Deck Surface Trajectory-based Operations (STBO): Results of Piloted Simulations and Implications for Concepts of Operation (ConOps)

    NASA Technical Reports Server (NTRS)

    Foyle, David C.; Hooey, Becky L.; Bakowski, Deborah L.

    2013-01-01

    The results offour piloted medium-fidelity simulations investigating flight deck surface trajectory-based operations (STBO) will be reviewed. In these flight deck STBO simulations, commercial transport pilots were given taxi clearances with time and/or speed components and required to taxi to the departing runway or an intermediate traffic intersection. Under a variety of concept of operations (ConOps) and flight deck information conditions, pilots' ability to taxi in compliance with the required time of arrival (RTA) at the designated airport location was measured. ConOps and flight deck information conditions explored included: Availability of taxi clearance speed and elapsed time information; Intermediate RTAs at intermediate time constraint points (e.g., intersection traffic flow points); STBO taxi clearances via ATC voice speed commands or datal ink; and, Availability of flight deck display algorithms to reduce STBO RTA error. Flight Deck Implications. Pilot RTA conformance for STBO clearances, in the form of ATC taxi clearances with associated speed requirements, was found to be relatively poor, unless the pilot is required to follow a precise speed and acceleration/deceleration profile. However, following such a precise speed profile results in inordinate head-down tracking of current ground speed, leading to potentially unsafe operations. Mitigating these results, and providing good taxi RTA performance without the associated safety issues, is a flight deck avionics or electronic flight bag (EFB) solution. Such a solution enables pilots to meet the taxi route RTA without moment-by-moment tracking of ground speed. An avionics or EFB "error-nulling" algorithm allows the pilot to view the STBO information when the pilot determines it is necessary and when workload alloys, thus enabling the pilot to spread his/her attention appropriately and strategically on aircraft separation airport navigation, and the many other flight deck tasks concurrently required

  15. Partial Genome Assembly for a Candidate Division OP11 Single Cell from an Anoxic Spring (Zodletone Spring, Oklahoma)▿†

    PubMed Central

    Youssef, Noha H.; Blainey, Paul C.; Quake, Stephen R.; Elshahed, Mostafa S.

    2011-01-01

    Members of candidate division OP11 are widely distributed in terrestrial and marine ecosystems, yet little information regarding their metabolic capabilities and ecological role within such habitats is currently available. Here, we report on the microfluidic isolation, multiple-displacement-amplification, pyrosequencing, and genomic analysis of a single cell (ZG1) belonging to candidate division OP11. Genome analysis of the ∼270-kb partial genome assembly obtained showed that it had no particular similarity to a specific phylum. Four hundred twenty-three open reading frames were identified, 46% of which had no function prediction. In-depth analysis revealed a heterotrophic lifestyle, with genes encoding endoglucanase, amylopullulanase, and laccase enzymes, suggesting a capacity for utilization of cellulose, starch, and, potentially, lignin, respectively. Genes encoding several glycolysis enzymes as well as formate utilization were identified, but no evidence for an electron transport chain was found. The presence of genes encoding various components of lipopolysaccharide biosynthesis indicates a Gram-negative bacterial cell wall. The partial genome also provides evidence for antibiotic resistance (β-lactamase, aminoglycoside phosphotransferase), as well as antibiotic production (bacteriocin) and extracellular bactericidal peptidases. Multiple mechanisms for stress response were identified, as were elements of type I and type IV secretion systems. Finally, housekeeping genes identified within the partial genome were used to demonstrate the OP11 affiliation of multiple hitherto unclassified genomic fragments from multiple database-deposited metagenomic data sets. These results provide the first glimpse into the lifestyle of a member of a ubiquitous, yet poorly understood bacterial candidate division. PMID:21908640

  16. Expression of baculovirus anti-apoptotic genes p35 and op-iap in cotton (Gossypium hirsutum L.) enhances tolerance to verticillium wilt.

    PubMed

    Tian, Juan; Zhang, Xueyan; Liang, Benguo; Li, Shanwei; Wu, Zhixia; Wang, Qianhua; Leng, Chunxu; Dong, Jiangli; Wang, Tao

    2010-12-03

    Programmed cell death plays an important role in mediating plant adaptive responses to the environment such as the invasion of pathogens. Verticillium wilt, caused by the necrotrophic pathogen Verticillium dahliae, is a serious vascular disease responsible for great economic losses to cotton, but the molecular mechanisms of verticillium disease and effective, safe methods of resistance to verticillium wilt remain unexplored. In this study, we introduced baculovirus apoptosis inhibitor genes p35 and op-iap into the genome of cotton via Agrobacterium-mediated transformation and analyzed the response of transgenic plants to verticillium wilt. Results showed that p35 and op-iap constructs were stably integrated into the cotton genome, expressed in the transgenic lines, and inherited through the T(3) generation. The transgenic lines had significantly increased tolerance to verticillium wilt throughout the developmental stages. The disease index of T(1)-T(3) generation was lower than 19, significantly (P<0.05) better than the negative control line z99668. After treatment with 250 mg/L VD-toxins for 36 hours, DNA from negative control leaves was fragmented, whereas fragmentation in the transgenic leaf DNA did not occur. The percentage of cell death in transgenic lines increased by 7.11% after 60 mg/L VD-toxin treatment, which was less than that of the negative control lines's 21.27%. This indicates that p35 and op-iap gene expression partially protects cells from VD-toxin induced programmed cell death (PCD). Verticillium dahliae can trigger plant cells to die through induction of a PCD mechanism involved in pathogenesis. This paper provides a potential strategy for engineering broad-spectrum necrotrophic disease resistance in plants.

  17. Evaluating a school-based fruit and vegetable co-op in low-income children: A quasi-experimental study.

    PubMed

    Sharma, Shreela V; Markham, Christine; Chow, Joanne; Ranjit, Nalini; Pomeroy, Michael; Raber, Margaret

    2016-10-01

    The purpose of this study was to evaluate the effectiveness of a new school-based food co-op program, Brighter Bites (BB), to increase fruit and vegetable intake, and home nutrition environment among low-income 1st graders and their parents. This was a non-randomized controlled comparative effectiveness trial (2013-2015). Six schools received BB (n=407 parent-child dyads); six comparison schools implemented a coordinated school health program (n=310 parent-child dyads) in Houston, Texas, 2013-2015. Brighter Bites (BB) is a 16-week school-based food co-op comprising weekly distribution of fresh produce (50 servings); nutrition education in schools and for parents; and weekly recipe tastings. Measurements included parent-reported home nutrition environment surveys, and food frequency questionnaires for parent and child. Intervention effects were examined using multivariate analyses. At baseline, the sample was 71% Hispanic, 24% African American; 43% of 1st graders were overweight/obese. Children receiving BB had significant increases in intake of fruit servings (P=0.046), vegetable servings (P=0.049), and decreased intake of added sugars (P=0.014). Among parents, there were significant increases in fruit consumed (P=0.032); vegetable intake increased baseline to midpoint but not post-intervention. Among BB families, there were significant improvements in the home environment including understanding and usage of nutrition facts labels to make food purchases (P<0.05), frequency of cooking (P=0.007), rules and practices regarding eating family meals (P=0.022), serving fruits (P=0.005) and vegetables (P=0.028) at meals, and limiting portion sizes (P=0.016). In conclusion, a school-based food co-op model shows promising results in improving dietary habits and home nutrition environment among low-income families. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. Expression of Baculovirus Anti-Apoptotic Genes p35 and op-iap in Cotton (Gossypium hirsutum L.) Enhances Tolerance to Verticillium Wilt

    PubMed Central

    Liang, Benguo; Li, Shanwei; Wu, Zhixia; Wang, Qianhua; Leng, Chunxu; Dong, Jiangli; Wang, Tao

    2010-01-01

    Background Programmed cell death plays an important role in mediating plant adaptive responses to the environment such as the invasion of pathogens. Verticillium wilt, caused by the necrotrophic pathogen Verticillium dahliae, is a serious vascular disease responsible for great economic losses to cotton, but the molecular mechanisms of verticillium disease and effective, safe methods of resistance to verticillium wilt remain unexplored. Methodology/Principal Findings In this study, we introduced baculovirus apoptosis inhibitor genes p35 and op-iap into the genome of cotton via Agrobacterium-mediated transformation and analyzed the response of transgenic plants to verticillium wilt. Results showed that p35 and op-iap constructs were stably integrated into the cotton genome, expressed in the transgenic lines, and inherited through the T3 generation. The transgenic lines had significantly increased tolerance to verticillium wilt throughout the developmental stages. The disease index of T1–T3 generation was lower than 19, significantly (P<0.05) better than the negative control line z99668. After treatment with 250 mg/L VD-toxins for 36 hours, DNA from negative control leaves was fragmented, whereas fragmentation in the transgenic leaf DNA did not occur. The percentage of cell death in transgenic lines increased by 7.11% after 60 mg/L VD-toxin treatment, which was less than that of the negative control lines's 21.27%. This indicates that p35 and op-iap gene expression partially protects cells from VD-toxin induced programmed cell death (PCD). Conclusion/Significance Verticillium dahliae can trigger plant cells to die through induction of a PCD mechanism involved in pathogenesis. This paper provides a potential strategy for engineering broad-spectrum necrotrophic disease resistance in plants. PMID:21151969

  19. Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14 463 cases and 44 188 controls

    PubMed Central

    Kang, Xiaozheng; Liu, Hongliang; Onaitis, Mark W.; Liu, Zhensheng; Owzar, Kouros; Han, Younghun; Su, Li; Wei, Yongyue; Hung, Rayjean J.; Brhane, Yonathan; McLaughlin, John; Brennan, Paul; Bickeböller, Heike; Rosenberger, Albert; Houlston, Richard S.; Caporaso, Neil; Landi, Maria Teresa; Heinrich, Joachim; Risch, Angela; Wu, Xifeng; Ye, Yuanqing; Christiani, David C.; Amos, Christopher I.; Wei, Qingyi

    2016-01-01

    Centrosome abnormalities are often observed in premalignant lesions and in situ tumors and have been associated with aneuploidy and tumor development. We investigated the associations of 9354 single-nucleotide polymorphisms (SNPs) in 106 centrosomal genes with lung cancer risk by first using the summary data from six published genome-wide association studies (GWASs) of the Transdisciplinary Research in Cancer of the Lung (TRICL) (12 160 cases and 16 838 controls) and then conducted in silico replication in two additional independent lung cancer GWASs of Harvard University (984 cases and 970 controls) and deCODE (1319 cases and 26 380 controls). A total of 44 significant SNPs with false discovery rate (FDR) ≤ 0.05 were mapped to one novel gene FGFR1OP and two previously reported genes (TUBB and BRCA2). After combined the results from TRICL with those from Harvard and deCODE, the most significant association (P combined = 8.032×10−6) was with rs151606 within FGFR1OP. The rs151606 T>G was associated with an increased risk of lung cancer [odds ratio (OR) = 1.10, 95% confidence interval (95% CI) = 1.05–1.14]. Another significant tagSNP rs12212247 T>C (P combined = 9.589×10−6) was associated with a decreased risk of lung cancer (OR = 0.93, 95% CI = 0.90–0.96). Further in silico functional analyzes revealed that rs151606 might affect transcriptional regulation and result in decreased FGFR1OP expression (P trend = 0.022). The findings shed some new light on the role of centrosome abnormalities in the susceptibility to lung carcinogenesis. PMID:26905588

  20. EFFECT OF HIGH-ENERGY RESONANCES ON THE {sup 18}O(p, {alpha}){sup 15}N REACTION RATE AT AGB AND POST-AGB RELEVANT TEMPERATURES

    SciTech Connect

    La Cognata, M.; Spitaleri, C.; Mukhamedzhanov, A. M.

    2010-11-10

    The {sup 18}O(p, {alpha}){sup 15}N reaction is of great importance in several astrophysical scenarios, as it influences the production of key isotopes such as {sup 19}F, {sup 18}O, and {sup 15}N. Fluorine is synthesized in the intershell region of asymptotic giant branch (AGB) stars, together with s-elements, by {alpha} radiative capture on {sup 15}N, which in turn is produced in the {sup 18}O proton-induced destruction. Peculiar {sup 18}O abundances are observed in R-Coronae Borealis stars, having {sup 16}O/{sup 18}O {approx}< 1, hundreds of times smaller than the galactic value. Finally, there is no definite explanation of the {sup 14}N/{sup 15}N ratio in pre-solar grains formed in the outer layers of AGB stars. Again, such an isotopic ratio is influenced by the {sup 18}O(p, {alpha}){sup 15}N reaction. In this work, a high accuracy {sup 18}O(p, {alpha}){sup 15}N reaction rate is proposed, based on the simultaneous fit of direct measurements and of the results of a new Trojan Horse experiment. Indeed, current determinations are uncertain because of the poor knowledge of the resonance parameters of key levels of {sup 19}F. In particular, we have focused on the study of the broad 660 keV 1/2{sup +} resonance corresponding to the 8.65 MeV level of {sup 19}F. Since {Gamma} {approx} 100-300 keV, it determines the low-energy tail of the resonant contribution to the cross section and dominates the cross section at higher energies. Here, we provide a reaction rate that is a factor of two larger above T {approx} 0.5 10{sup 9} K based on our new improved determination of its resonance parameters, which could strongly influence present-day astrophysical model predictions.

  1. The impact of the revised 17O(p, α)14N reaction rate on 17O stellar abundances and yields

    NASA Astrophysics Data System (ADS)

    Straniero, O.; Bruno, C. G.; Aliotta, M.; Best, A.; Boeltzig, A.; Bemmerer, D.; Broggini, C.; Caciolli, A.; Cavanna, F.; Ciani, G. F.; Corvisiero, P.; Cristallo, S.; Davinson, T.; Depalo, R.; Di Leva, A.; Elekes, Z.; Ferraro, F.; Formicola, A.; Fülöp, Zs.; Gervino, G.; Guglielmetti, A.; Gustavino, C.; Gyürky, G.; Imbriani, G.; Junker, M.; Menegazzo, R.; Mossa, V.; Pantaleo, F. R.; Piatti, D.; Piersanti, L.; Prati, P.; Samorjai, E.; Strieder, F.; Szücs, T.; Takács, M. P.; Trezzi, D.

    2017-02-01

    Context. Material processed by the CNO cycle in stellar interiors is enriched in 17O. When mixing processes from the stellar surface reach these layers, as occurs when stars become red giants and undergo the first dredge up, the abundance of 17O increases. Such an occurrence explains the drop of the 16O/17O observed in RGB stars with mass larger than 1.5M⊙. As a consequence, the interstellar medium is continuously polluted by the wind of evolved stars enriched in 17O. Aims: Recently, the Laboratory for Underground Nuclear Astrophysics (LUNA) collaboration released an improved rate of the 17O(p, α)14N reaction. In this paper we discuss the impact that the revised rate has on the 16O/17O ratio at the stellar surface and on 17O stellar yields. Methods: We computed stellar models of initial mass between 1 and 20 M⊙ and compared the results obtained by adopting the revised rate of the 17O(p, α)14N to those obtained using previous rates. Results: The post-first dredge up 16O/17O ratios are about 20% larger than previously obtained. Negligible variations are found in the case of the second and the third dredge up. In spite of the larger 17O(p, α)14N rate, we confirm previous claims that an extra-mixing process on the red giant branch, commonly invoked to explain the low carbon isotopic ratio observed in bright low-mass giant stars, marginally affects the 16O/17O ratio. Possible effects on AGB extra-mixing episodes are also discussed. As a whole, a substantial reduction of 17O stellar yields is found. In particular, the net yield of stars with mass ranging between 2 and 20 M⊙ is 15 to 40% smaller than previously estimated. Conclusions: The revision of the 17O(p, α)14N rate has a major impact on the interpretation of the 16O/17O observed in evolved giants, in stardust grains and on the 17O stellar yields.

  2. Root Zone Soil Moisture (RZSM) Estimates Using VHF (240-270 MHZ) Antenna for SoOp (Signal of Opportunity) Receiver for 6U CubeSat Platforms

    NASA Astrophysics Data System (ADS)

    Joseph, A. T.

    2015-12-01

    The main goal of this research is to develop VHF antennas for 6U Cubesat platforms to enable validation of root zone soil moisture (RZSM) estimation algorithms for signal of opportunity (SoOp) remote sensing over the 240-270 MHz frequency band. This study provides a strong foundation for establishing a path for maturing truly global direct surface soil moisture (SM) and RZSM measurement system over a variety of land covers with limited density restrictions. In SoOp methodology, signals transmitted by already existing transmitters, in this case the Military Satellite Communication (MilSatCom) System's UHF Follow-On program, are utilized to measure properties of reflecting targets by recording reflected signals using a simple passive microwave receiver. We developed and will test VHF (240-270 MHz) antenna technology for SoOp receivers for 6U Cubesat platforms and perform measurement of SM and RZSM using the proposed antennas deployed on a ground-based Soil Moisture Active Passive (SMAP) simulator boom truck. We will validate the RZSM and SM estimation algorithms from measured data (where RZSM is defined as the volumetric SM contained in the top 1 m of the soil column). Knowledge of RZSM up to a depth of 1 m and surface SM up to a depth of 0.05 m on a global scale, at a spatial resolution of 1-10 km through moderate-to-heavy vegetation, is critical to understanding global water resources and the vertical moisture gradient in the Earth's surface layer which controls moisture interactions between the soil, vegetation, and atmosphere. Current observations of surface SM from space by L-band radiometers and radars are limited to measurements of surface SM up to a depth of ~0.05 m through moderate amounts of vegetation. Developing bi-static reflectometry using VHF geostationary satellite SoOp creates the potential of directly observing SM and RZSM on a truly global basis from a constellation of small satellite-based receivers in low earth orbit. The technique provides the

  3. Biodistribution, Pharmacokinetics, and Dosimetry of (177)Lu-, (90)Y-, and (111)In-Labeled Somatostatin Receptor Antagonist OPS201 in Comparison to the Agonist (177)Lu-DOTATATE: The Mass Effect.

    PubMed

    Nicolas, Guillaume P; Mansi, Rosalba; McDougall, Lisa; Kaufmann, Jens; Bouterfa, Hakim; Wild, Damian; Fani, Melpomeni

    2017-09-01

    Radiolabeled somatostatin receptor (SSTR) antagonists have shown in vivo higher uptake in SSTR-expressing tumors than agonists. In this preclinical study, the SSTR2 antagonist OPS201 (DOTA-JR11; DOTA-[Cpa-c(DCys-Aph(Hor)-DAph(Cbm)-Lys-Thr-Cys)-DTyr-NH2]) labeled with (177)Lu, (90)Y, and (111)In was compared with the SSTR2 agonist (177)Lu-DOTATATE. Methods: Biodistribution, pharmacokinetics, SPECT/CT, and dosimetry studies were performed to assess the bioequivalence of all radiotracers. Use of escalated peptide mass and nephroprotective agents were systematically investigated. Results: The tumor residence time was 15.6 h (13.4-17.7) for (177)Lu-OPS201 (10 pmol) and 6.4 h (5.4-7.3) for (177)Lu-DOTATATE, resulting in a 2.5-times-higher tumor dose for the antagonist than for the agonist (0.854 vs. 0.333 mGy/MBq for a 4-cm tumor). The overall tumor-to-kidney dose ratio was approximately 24% and 32% higher for (177)Lu-OPS201 than for (90)Y-OPS201 and (177)Lu-DOTATATE, respectively. (111)In-OPS201 had a biodistribution significantly different from (90)Y-OPS201 and is therefore not a surrogate for (90)Y-OPS201 dosimetry studies. Importantly, and in contrast to (177)Lu-DOTATATE, injection of 10, 200, and 2,000 pmol of (177)Lu-OPS201 did not cause any relevant tumor saturation, with tumor uptake 4 h after injection: 23.9, 24.9, and 18.8 percentage of injected activity per gram of tissue (%IA/g), respectively, for the antagonist (P > 0.05), as compared with 17.8, 12.0, and 9.9 %IA/g for the agonist (P < 0.05). Increasing the peptide mass of (177)Lu-OPS201 from 10 to 200 pmol drastically decreased the effective dose from 0.0908 to 0.0184 mSv/MBq and decreased the uptake in the liver, bone marrow, and all SSTR2-expressing organs; thus, the therapeutic index improved considerably. Lysine and succinylated gelatine, alone or in combination, significantly reduced the renal dose of (177)Lu-OPS201 compared with the control group, by 45%, 25%, and 40%, respectively (P < 0.05). The

  4. OH reactivity in a South East Asian tropical rainforest during the Oxidant and Particle Photochemical Processes (OP3) project

    NASA Astrophysics Data System (ADS)

    Edwards, P. M.; Evans, M. J.; Furneaux, K. L.; Hopkins, J.; Ingham, T.; Jones, C.; Lee, J. D.; Lewis, A. C.; Moller, S. J.; Stone, D.; Whalley, L. K.; Heard, D. E.

    2013-09-01

    OH (hydroxyl radical) reactivity, the inverse of the chemical lifetime of the hydroxyl radical, was measured for 12 days in April 2008 within a tropical rainforest on Borneo as part of the OP3 (Oxidant and Particle Photochemical Processes) project. The maximum observed value was 83.8 ± 26.0 s-1 with the campaign averaged noontime maximum being 29.1 ± 8.5 s-1. The maximum OH reactivity calculated using the diurnally averaged concentrations of observed sinks was ~ 18 s-1, significantly less than the observations, consistent with other studies in similar environments. OH reactivity was dominated by reaction with isoprene (~ 30%). Numerical simulations of isoprene oxidation using the Master Chemical Mechanism (v3.2) in a highly simplified physical and chemical environment show that the steady state OH reactivity is a linear function of the OH reactivity due to isoprene alone, with a maximum multiplier, to account for the OH reactivity of the isoprene oxidation products, being equal to the number of isoprene OH attackable bonds (10). Thus the emission of isoprene constitutes a significantly larger emission of reactivity than is offered by the primary reaction with isoprene alone, with significant scope for the secondary oxidation products of isoprene to constitute the observed missing OH reactivity. A physically and chemically more sophisticated simulation (including physical loss, photolysis, and other oxidants) showed that the calculated OH reactivity is reduced by the removal of the OH attackable bonds by other oxidants and photolysis, and by physical loss (mixing and deposition). The calculated OH reactivity is increased by peroxide cycling, and by the OH concentration itself. Notable in these calculations is that the accumulated OH reactivity from isoprene, defined as the total OH reactivity of an emitted isoprene molecule and all of its oxidation products, is significantly larger than the reactivity due to isoprene itself and critically depends on the chemical

  5. OH reactivity in a South East Asian Tropical rainforest during the Oxidant and Particle Photochemical Processes (OP3) project

    NASA Astrophysics Data System (ADS)

    Edwards, P. M.; Evans, M. J.; Furneaux, K. L.; Hopkins, J.; Ingham, T.; Jones, C.; Lee, J. D.; Lewis, A. C.; Moller, S. J.; Stone, D.; Whalley, L. K.; Heard, D. E.

    2013-02-01

    OH reactivity, the reciprocal of its lifetime from reaction with its sinks, was measured for 12 days in April 2008 within a tropical rainforest on Borneo as part of the OP3 project. The maximum observed value was 83.8 ± 26.0 s-1 with the campaign averaged noon-time maximum being 29.1 ± 8.5 s-1. The maximum OH reactivity calculated using the campaign averaged noon-time concentrations of observed sinks was ~18 s-1, significantly less than the observations, consistent with other studies in similar environments. OH reactivity was dominated by reaction with isoprene. Numerical simulations of isoprene oxidation using the Master Chemical Mechanism (v3.2) in a highly simplified physical and chemical environment show that the steady state OH reactivity is a linear function of the OH reactivity due to isoprene alone, with a maximum multiplier being equal to the number of isoprene OH attackable bonds (10). Thus the emission of isoprene constitutes a significantly larger emission of reactivity than is offered by the primary reaction with isoprene alone, with significant scope for the secondary oxidation products of isoprene to constitute the missing reactivity. A physically and chemically more sophisticated simulation (including physical loss, photolysis, and other oxidants) showed that the calculated OH reactivity is reduced by the removal of the OH attackable bonds by other oxidants and photolysis, and by physical loss (mixing and deposition). The calculated OH reactivity is increased by peroxide cycling, and by the OH concentration itself. Notable in these calculations is that the lifetime of OH reactivity is significantly longer than the lifetime of isoprene and critically depends on the chemical and physical lifetime of intermediate species. When constrained to the observed campaign averaged diurnal concentrations of primary volatile organic compounds (VOCs), O3, nitrogen oxides (NOx) and other parameters, the model underestimated the observed mean OH reactivity by 30

  6. Positive iodine-131 6 beta-iodomethyl-19-norcholesterol (NP-59) adrenal images can precede return of adrenocortical function after o,p' DDD treatment

    SciTech Connect

    Sparagana, M.; Ackerman, L.

    1988-05-01

    A patient with bilateral adrenal hyperplasia, due to the ectopic adrenocorticotrophic hormone (ACTH) syndrome, received a 3-month course of treatment with 1,1 dichloro-2(o-chlorophenyl)-2-(p-chlorophenyl)ethane (o,p' DDD), which caused adrenal hypofunction requiring steroid therapy. Eleven months later, Cushing's syndrome recurred. His CT scan showed a left adrenal gland that was enlarged and a normal-sized right adrenal gland. However, the NP-59 image showed increased uptake by both glands. Venous effluent was sampled from each adrenal vein. The plasma cortisol level from the left gland was 1392 ng/ml, and that from the right gland was 667 ng/ml. The latter value was not significantly different from the values obtained at peripheral sites (517-744 ng/ml). In the course of recovery from o,p' DDD damage, the ability of the adrenal gland to take up NP-59 may be restored before the return of its biosynthetic and secretory functions. Serial NP-59 adrenal images can anticipate the recurrence of Cushing's syndrome after adrenolytic therapy, thereby permitting early retreatment.

  7. Air quality monitoring with current (IASI) and future (IASI-NG/MetOp-SG, IRS/MTG) space-borne thermal infrared sounders

    NASA Astrophysics Data System (ADS)

    Boynard, Anne; Clerbaux, Cathy; Bauduin, Sophie; Prunet, Pascal; Tournier, Bernard; Hadji-Lazaro, Juliette; Hurtmans, Daniel; Coheur, Pierre-François

    2017-04-01

    Current nadir-looking thermal infrared (TIR) sounders, such as the Infrared Atmospheric Sounding Interferometer (IASI) launched onboard the MetOp polar-orbiting platforms, are now playing an important role for probing pollutants in the troposphere and in the boundary layer (e.g., carbon monoxide - CO, ozone - O3, ammonia, sulfur dioxide). Vertical profiles can be obtained for the main absorbers, with varying vertical resolution and accuracy, depending on geophysical parameters and instrumental specifications. Two future missions using TIR instruments (IRS on Sentinel 4/MTG geostationary-orbiting platform and IASI-NG on Sentinel 5/MetOp-SG polar-orbiting platform) are planned to be launched by EUMETSAT within 5 years. Both instruments are nadir looking Fourier transform spectrometers like IASI but with different radiometric and spectral characteristics. In this study, we illustrate the ability of IASI to monitor CO and O3 in the lowermost troposphere. We assess more specifically the performances of the different satellite instrument concepts in terms of vertical resolution and sensitivity at the surface for CO and O3, using representative cases at local, continental and global scales.

  8. Technical note: some observations on the conversion of dental enamel δ18O(p) values to δ18O(w) to determine human mobility.

    PubMed

    Pollard, A M; Pellegrini, M; Lee-Thorp, J A

    2011-07-01

    It has become a widespread practice to convert δ(18)O(p) values measured in human and animal dental enamel to a corresponding value of δ(18)O(w) and compare these data with mapped δ(18)O(w) groundwater or meteoric water values to locate the region where the owner of the tooth lived during the formation of the enamel. Because this is a regression procedure, the errors associated with the predicted δ(18)O(w) values will depend critically on the correlation between the comparative data used to perform the regression. By comparing four widely used regression equations we demonstrate that the smallest 95% error is likely to be greater than ±1% in δ(18)O(w) , and could be as large as ±3.5%. These values are significantly higher than those quoted in some of the recent literature, and measurements with errors at the higher end of this range would render many of the published geographical attributions statistically unsupportable. We suggest that the simplest solution to this situation is to make geographical attributions based on the direct comparison of measured values of δ(18)O(p) rather than on predicted values of δ(18)O(w). Copyright © 2011 Wiley-Liss, Inc.

  9. Orthogonal projection (OP) technique applied to pattern recognition of fingerprints of the herbal medicine houttuynia cordata Thunb. and its final injection products.

    PubMed

    Zeng, Zhong-Da; Liang, Yi-Zeng; Zhang, Ting; Chau, Foo-Tim; Wang, Ya-Li

    2006-05-01

    It is a crucial issue to determine the origins of herbal medicinal materials and identify the quality grades and fakes of their final products collected from different pharmaceutical corporations. Pattern recognition technique may assist the manufacturers to achieve this purpose and effectively control the quality of their products. In this work, a widely used method in chemometrics, orthogonal projection (OP) technique, was applied to discrimination analysis and identification of fingerprints of the herbal medicine houttuynia cordata Thunb. (HCT) and its final injection products. The advantages of the OP technique are clearly shown after comparing with the conventional methods such as principal component analysis (PCA), Mahalanobis distance (MD), and similarity comparison method (SCM). Three different sources of medicinal material HCT and its final injection products from six different manufacturers were studied under 'sixfold', 'threefold' and 'threefold-bis' cross-validation procedures. The good performance of the proposed method in determination and identification of unknown samples shows it could be a powerful tool for quality control in herbal medicine production and other related research fields.

  10. Synthesis and in vitro kinetic study of novel mono-pyridinium oximes as reactivators of organophosphorus (OP) inhibited human acetylcholinesterase (hAChE).

    PubMed

    Valiveti, Aditya Kapil; Bhalerao, Uma M; Acharya, Jyotiranjan; Karade, Hitendra N; Gundapu, Raviraju; Halve, Anand K; Kaushik, Mahabir Parshad

    2015-07-25

    A series of mono pyridinium oximes linked with arenylacetamides as side chains were synthesized and their in vitro reactivation potential was evaluated against human acetylcholinesterase (hAChE) inhibited by organophosphorus inhibitors (OP) such as sarin, VX and tabun. The reactivation data of the synthesized compounds were compared with those obtained with standard reactivators such as 2-PAM and obidoxime. The dissociation constant (KD) and specific reactivity (kr) of the oximes were also determined by performing reactivation kinetics against OP inhibited hAChE. Among the synthesized compounds, oximes 1-(2-(4-cyanophenylamino)-2-oxoethyl)-4-((hydroxyimino)methyl)pyridinium chloride (12a) and 4-((hydroxyimino)methyl)-1-(2-(4-methoxyphenylamino)-2-oxoethyl)pyridinium chloride (2a) were found most potent reactivators for hAChE inhibited by sarin. In case of VX inhibited hAChE majority of the oximes have shown good reactivation efficacies. Among these oximes 1-(2-(benzylamino)-2-oxoethyl)-4-((hydroxyimino)methyl)pyridinium chloride (18a), 4-((hydroxyimino)methyl)-1-(2-(4-(methoxycarbonyl)phenylamino)-2-oxoethyl)pyridinium-chloride (14a) and 12a were found to surpass the reactivation potential of 2-PAM and obidoxime. However, the synthesized oximes showed marginal reactivation efficacies in case of tabun inhibited hAChE. The pKa value of the oximes were determined and correlated with their observed reactivation potential.

  11. The implementation of the serial trial intervention for pain and challenging behaviour in advanced dementia patients (STA OP!): a clustered randomized controlled trial

    PubMed Central

    2011-01-01

    Background Pain (physical discomfort) and challenging behaviour are highly prevalent in nursing home residents with dementia: at any given time 45-80% of nursing home residents are in pain and up to 80% have challenging behaviour. In the USA Christine Kovach developed the serial trial intervention (STI) and established that this protocol leads to less discomfort and fewer behavioural symptoms in moderate to severe dementia patients. The present study will provide insight into the effects of implementation of the Dutch version of the STI-protocol (STA OP!) in comparison with a control intervention, not only on behavioural symptoms, but also on pain, depression, and quality of life. This article outlines the study protocol. Methods/Design The study is a cluster randomized controlled trial in 168 older people (aged >65 years) with mild or moderate dementia living in nursing homes. The clusters, Dutch nursing homes, are randomly assigned to either the intervention condition (training and implementation of the STA OP!-protocol) or the control condition (general training focusing on challenging behaviour and pain, but without the step-wise approach). Measurements take place at baseline, after 3 months (end of the STA OP! training period) and after 6 months. Primary outcome measures are symptoms of challenging behaviour (measured with the Cohen-Mansfield Agitation Inventory (CMAI) and the Neuropsychiatric Inventory-Nursing Home version (NPI-NH)), and pain (measure with the Dutch version of the Pain Assessment Checklist for Seniors (PACSLAC-D) and the Minimum Data Set of the Resident Assessment Instrument (MDS-RAI) pain scale). Secondary outcome measures include symptoms of depression (Cornell and MDS-RAI depression scale), Quality of Live (Qualidem), changes in prescriptions of analgesics and psychotropic drugs, and the use of non-pharmacological comfort interventions (e.g. snoezelen, reminiscence therapy). Discussion The transfer from the American design to the Dutch

  12. The implementation of the serial trial intervention for pain and challenging behaviour in advanced dementia patients (STA OP!): a clustered randomized controlled trial.

    PubMed

    Pieper, Marjoleine J C; Achterberg, Wilco P; Francke, Anneke L; van der Steen, Jenny T; Scherder, Erik J A; Kovach, Christine R

    2011-03-24

    Pain (physical discomfort) and challenging behaviour are highly prevalent in nursing home residents with dementia: at any given time 45-80% of nursing home residents are in pain and up to 80% have challenging behaviour. In the USA Christine Kovach developed the serial trial intervention (STI) and established that this protocol leads to less discomfort and fewer behavioural symptoms in moderate to severe dementia patients. The present study will provide insight into the effects of implementation of the Dutch version of the STI-protocol (STA OP!) in comparison with a control intervention, not only on behavioural symptoms, but also on pain, depression, and quality of life. This article outlines the study protocol. The study is a cluster randomized controlled trial in 168 older people (aged >65 years) with mild or moderate dementia living in nursing homes. The clusters, Dutch nursing homes, are randomly assigned to either the intervention condition (training and implementation of the STA OP!-protocol) or the control condition (general training focusing on challenging behaviour and pain, but without the step-wise approach). Measurements take place at baseline, after 3 months (end of the STA OP! training period) and after 6 months.Primary outcome measures are symptoms of challenging behaviour (measured with the Cohen-Mansfield Agitation Inventory (CMAI) and the Neuropsychiatric Inventory-Nursing Home version (NPI-NH)), and pain (measure with the Dutch version of the Pain Assessment Checklist for Seniors (PACSLAC-D) and the Minimum Data Set of the Resident Assessment Instrument (MDS-RAI) pain scale). Secondary outcome measures include symptoms of depression (Cornell and MDS-RAI depression scale), Quality of Live (Qualidem), changes in prescriptions of analgesics and psychotropic drugs, and the use of non-pharmacological comfort interventions (e.g. snoezelen, reminiscence therapy). The transfer from the American design to the Dutch design involved several changes due to

  13. Pulsed, tunable, single-frequency OP-GaAs OPO for the standoff detection of hazardous chemicals in the longwave infrared

    NASA Astrophysics Data System (ADS)

    Clément, Q.; Melkonian, J.-M.; Dherbecourt, J.-B.; Raybaut, M.; Grisard, A.; Lallier, E.; Gérard, B.; Faure, B.; Souhaité, G.; Godard, A.

    2015-10-01

    We present our results on the first nanosecond single-frequency optical parametric oscillator (OPO) emitting in the longwave infrared. It is based on orientation-patterned GaAs (OP-GaAs), and can be pumped by a pulsed singlefrequency Tm:YAP microlaser thanks to its low oscillation threshold of 10 μJ. Stable single-longitudinal mode emission of the OPO is obtained owing to Vernier spectral filtering provided by its nested cavity OPO (NesCOPO) scheme. Crystal temperature tuning covers the 10.3-10.9 μm range with a single quasi-phase-matching period of 72.6 μm. Shortrange standoff detection of ammonia vapor around 10.4 μm is performed with this source. We believe that this achievement paves the way to differential absorption lidars in the LWIR with increased robustness and reduced footprint.

  14. 1.95  μm-pumped OP-GaAs optical parametric oscillator with 10.6  μm idler wavelength.

    PubMed

    Wueppen, Jochen; Nyga, Sebastian; Jungbluth, Bernd; Hoffmann, Dieter

    2016-09-15

    We report on an optical parametric oscillator that generates output idler wavelengths around 10.6 μm. On the basis of orientation-patterned gallium arsenide (OP-GaAs) as a nonlinear medium and a 1.95 μm ns-pulsed pump laser, a signal-resonant bow-tie resonator was designed in order to maximize the output power at moderate intensities well below the damage threshold of the optical components. With this setup, the average idler output power at 50 kHz and 100 ns idler pulse length was more than 800 mW, which corresponds to a pulse energy of 16 μJ. The maximum quantum conversion efficiency of 36.8% is the highest value measured so far for comparable setups to the best of our knowledge.

  15. Biogenic VOC measurements during the Oxidant and Particle Photochemical Processes (OP3) above a South-East Asian tropical rainforest Campaign

    NASA Astrophysics Data System (ADS)

    Jones, Charlotte; Hopkins, James; Lee, James; Lewis, Alastair; Hamilton, Jacqueline

    2010-05-01

    We present the first ambient air speciated monoterpene measurements from the UK FGAM (Facility for Ground based Atmospheric Measrements) - York dual channel gas chromatograph system with flame ionisation detectors, alongside measurements of other biogenic volatile organic compounds (BVOCs) such as isoprene, which were made during the Oxidant and Particle Photochemical Processes above a South-East Asian tropical rainforest (OP3) campaign in Danum Valley, Borneo, in 2008. The monoterpenes measured were alpha-pinene, camphene, 3-carene, gamma-terpinene and limonene. We compare the relative concentrations and diurnal profiles of the different monoterpene species and other BVOCs such as isoprene, and analyse variability in their concentrations in light of various environmental conditions, in order to gain insight into factors which influence their emission rates, and therefore regulate their potential impact upon photochemical processes within the boundary layer. We also present regional BVOC measurements made onboard the FAAM BAE 146 aircraft over both the natural rainforest and oil palm plantations.

  16. J1-J2 square-lattice Heisenberg antiferromagnets with 4 d1 spins: A MoOP O4Cl (A =K ,Rb )

    NASA Astrophysics Data System (ADS)

    Ishikawa, Hajime; Nakamura, Nanako; Yoshida, Makoto; Takigawa, Masashi; Babkevich, Peter; Qureshi, Navid; Rønnow, Henrik M.; Yajima, Takeshi; Hiroi, Zenji

    2017-02-01

    Magnetic properties of A MoOP O4Cl (A =K ,Rb ) with M o5 + ions in the 4 d1 electronic configuration are investigated by magnetization, heat capacity, and nuclear magnetic resonance (NMR) measurements on single crystals, combined with powder neutron diffraction experiments. The magnetization measurements reveal that they are good model compounds for the spin-1/2 J1-J2 square-lattice magnet with the first and second nearest-neighbor interactions. Magnetic transitions are observed at around 6 and 8 K in the K and Rb compounds, respectively. In contrast to the normal Néel-type antiferromagnetic order, the NMR and neutron diffraction experiments find a columnar antiferromagnetic order for each compound, which is stabilized by a dominant antiferromagnetic J2. Both compounds realize the unusual case of two interpenetrating J2 square lattices weakly coupled to each other by J1.

  17. Cross-validation of IASI/MetOp derived tropospheric δD with TES and ground-based FTIR observations

    NASA Astrophysics Data System (ADS)

    Lacour, J.-L.; Clarisse, L.; Worden, J.; Schneider, M.; Barthlott, S.; Hase, F.; Risi, C.; Clerbaux, C.; Hurtmans, D.; Coheur, P.-F.

    2014-11-01

    The Infrared Atmospheric Sounding Interferometer (IASI) flying on-board MetOpA and MetOpB is able to capture fine isotopic variations of the HDO to H2O ratio (δD) in the troposphere. Such observations at the high spatio temporal resolution of the sounder are of great interest to improve our understanding of the mechanisms controlling humidity in the troposphere. In this study we aim to empirically assess the validity of our error estimation previously evaluated theoretically. To achieve this, we compare IASI δD retrieved profiles with other available profiles of δD, from the TES infrared sounder onboard AURA and from three ground-based FTIR stations produced within the MUSICA project: the NDACC (Network for the Detection of Atmospheric Composition Change) sites Kiruna and Izana, and the TCCON site Karlsruhe, which in addition to near-infrared TCCON spectra also records mid-infrared spectra. We describe the achievable level of agreement between the different retrievals and show that these theoretical errors are in good agreement with empirical differences. The comparisons are made at different locations from tropical to Arctic latitudes, above sea and above land. Generally IASI and TES are similarly sensitive to δD in the free troposphere which allows to compare their measurements directly. At tropical latitudes where IASI's sensitivity is lower than that of TES, we show that the agreement improves when taking into account the sensitivity of IASI in the TES retrieval. For the comparison IASI-FTIR only direct comparisons are performed because of similar sensitivities. We identify a quasi negligible bias in the free troposphere (-3‰) between IASI retrieved δD with the TES one, which are bias corrected, but an important with the ground-based FTIR reaching -47‰. We also suggest that model-satellite observations comparisons could be optimized with IASI thanks to its high spatial and temporal sampling.

  18. Monitoring of greenhouse gas emissions in urban environments using ground-based open-path Fourier-transform Infrared (OP-FTIR) Spectroscopy

    NASA Astrophysics Data System (ADS)

    Schuetze, C.; Sauer, U.; Dietrich, P.

    2013-12-01

    Ground-based optical remote sensing has become an essential technology for quantifying pollutant or greenhouese gas (GHG) emissions from point or area sources and for the validation of airborne or satellite remote sensing data. Extensive studies have shown the capability of both ground and airborne surveys in meeting the necessary requirements for large-scale monitoring programs of atmospheric gas variations, e.g. in urban environments or regions with variable land use intensity. Open path instruments (such as infrared or laser spectrometer) that can rapidly scan in ambient air over significant distances are especially useful tools when it comes to detecting any GHG concentration variations (e.g. carbon dioxide CO2, nitrous oxide N2O, methane CH4) that are above normal background levels. Fourier-transform infrared spectroscopy is proven to be a powerful and non-invasive technique that can be used for online monitoring of fugitive emissions for industrial, environmental and health applications. We applied ground-based OP-FTIR spectroscopy as part of a hierarchical monitoring concept to investigate path-averaged atmospheric composition on a large scale, in terms of identifying areas with higher emission rates that subsequently require further detailed meso-scale investigations. A mobile passive and a bistatic active OP-FTIR spectrometer system (Bruker) were installed and a survey of column abundances of CO2 and several other trace gases was performed, allowing a maximum spatial coverage area of several square km to be mapped. In this presentation, we show results of a feasibility study investigating various scenarios (such as a Central European urban region, an agricultural landscape and a natural CO2 degassing area). The data were analysed and compared with accompanying in-situ geophysical, soil gas and micro-meteorological investigation results. Here, we present the significant spatial and temporal variability of CO2 emissions related to local anomalies, temporal

  19. Armatimonas rosea gen. nov., sp. nov., of a novel bacterial phylum, Armatimonadetes phyl. nov., formally called the candidate phylum OP10.

    PubMed

    Tamaki, Hideyuki; Tanaka, Yasuhiro; Matsuzawa, Hiroaki; Muramatsu, Mizuho; Meng, Xian-Ying; Hanada, Satoshi; Mori, Kazuhiro; Kamagata, Yoichi

    2011-06-01

    A novel aerobic, chemoheterotrophic bacterium, strain YO-36(T), isolated from the rhizoplane of an aquatic plant (a reed, Phragmites australis) inhabiting a freshwater lake in Japan, was morphologically, physiologically and phylogenetically characterized. Strain YO-36(T) was Gram-negative and ovoid to rod-shaped, and formed pinkish hard colonies on agar plates. Strain YO-36(T) grew at 20-40 °C with optimum growth at 30-35 °C, whilst no growth was observed at 15 °C or 45 °C. The pH range for growth was 5.5-8.5 with an optimum at pH 6.5. Strain YO-36(T) utilized a limited range of substrates, such as sucrose, gentiobiose, pectin, gellan gum and xanthan gum. The strain contained C(16 : 0), C(16 : 1), C(14 : 0) and C(15 : 0) as the major cellular fatty acids and menaquinone-12 as the respiratory quinone. The G+C content of the genomic DNA was 62.4 mol%. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain YO-36(T) belonged to the candidate phylum OP10 comprised solely of environmental 16S rRNA gene clone sequences except for two strains, P488 and T49 isolated from geothermal soil in New Zealand; strain YO-36(T) showed less than 80 % sequence similarity to strains P488 and T47. Based on the phylogetic and phenotypic findings, a new genus and species, Armatimonas rosea gen. nov., sp. nov., is proposed for the isolate (type strain YO-36(T)  = NBRC 105658(T)  = DSM 23562(T)). In addition, a new bacterial phylum named Armatimonadetes phyl. nov. is proposed for the candidate phylum OP10 represented by A. rosea gen. nov., sp. nov. and Armatimonadaceae fam. nov., Armatimonadales ord. nov., and Armatimonadia classis nov.

  20. Mechanical evaluation of mandibular defects reconstructed using osteogenic protein-1 (rhOP-1) in a sheep model: a critical analysis.

    PubMed

    Abu-Serriah, M; Kontaxis, A; Ayoub, A; Harrison, J; Odell, E; Barbenel, J

    2005-05-01

    Osteoinductive bone morphogenetic proteins (BMPs) have been used extensively in experimental and clinical orthopaedic research. It is a natural progression for these growth regulators to be tested in the craniofacial region. The aim of this investigation was to analyse the mechanical properties of the sheep mandibles reconstructed using recombinant human osteogenic protein type 1 (rhOP-1). A unilateral 35 mm osteoperiosteal continuity defect was created at the parasymphyseal region of the mandible in six adult sheep. The animals were sacrificed 3 months after surgery and mechanical properties of the regenerated bone at the operated sides (OS) were compared to the corresponding bone at the non-operated side (NOS). The regenerated tissue at the OS were then submitted for histological and histomorphometric analysis. Although all the animals achieved complete bony union, a wide range of mechanical properties was found. The rhOP-1-induced bone achieved a mean of 36% of the strength of the bone at the NOS (P < 0.05). The mean value of the stiffness of the OS was 24% of the NOS (P < 0.05). While half of the samples of the OS had 'weak' mechanical properties (9-25% strength compared to NOS) and a low stiffness (6-18%), the rest showed relatively higher strength (47-63%) and were stiffer (35-47%). Unlike the NOS, the operated sides failed under tensile stresses and cracks initiated at the superior border of the mandible. The wide mechanical variations suggest that further basic bone biology research is needed to provide better understanding of the cellular and molecular events which take place during the process of osteoinduction.

  1. A COMPARATIVE INVESTIGATION OF THE INFLUENCE OF DERMAL APPENDAGES (HAIR FOLLICLES) ON THE PERCUTANEOUS ABSORPTION OF ORGANOPHOSPHORUS (OP) INSECTICIDES USING QSAR AND PBPK/PD MODELS FOR HUMAN RISK ASSESSMENT

    EPA Science Inventory

    The successful use of the Exposure Related Dose Estimating Model (ERDEM) for assessment of dermal exposure of humans to OP pesticides requires the input of representative and comparable input parameters. In the specific case of dermal exposure, regional anatomical variation in...

  2. A COMPARATIVE INVESTIGATION OF THE INFLUENCE OF DERMAL APPENDAGES (HAIR FOLLICLES) ON THE PERCUTANEOUS ABSORPTION OF ORGANOPHOSPHORUS (OP) INSECTICIDES USING QSAR AND PBPK/PD MODELS FOR HUMAN RISK ASSESSMENT

    EPA Science Inventory

    The successful use of the Exposure Related Dose Estimating Model (ERDEM) for assessment of dermal exposure of humans to OP pesticides requires the input of representative and comparable input parameters. In the specific case of dermal exposure, regional anatomical variation in...

  3. New insights into the regulatory pathways associated with the activation of the stringent response in bacterial resistance to the PBP2-targeted antibiotics, mecillinam and OP0595/RG6080.

    PubMed

    Doumith, M; Mushtaq, S; Livermore, D M; Woodford, N

    2016-10-01

    The diazabicyclooctane β-lactamase inhibitor OP0595 (RG6080) also acts as an antibiotic, targeting PBP2 in Enterobacteriaceae, but this activity is vulnerable to mutational resistance. We used WGS to investigate the basis of this resistance. Twenty OP0595-selected mutants, comprising four derived from each of five different Escherichia coli strains, were sequenced on Illumina HiSeq. Reads from each mutant were mapped to the assembled genome of the corresponding parent. A variant-calling file generated with Samtools was parsed to determine genetic alterations. Besides OP0595, the mutants consistently showed decreased susceptibility to mecillinam, which likewise targets PBP2, and grew as stable round forms in the presence of subinhibitory concentrations of OP0595. Among the 20 mutants, 18 had alterations in genes encoding tRNA synthase and modification functions liable to induce expression of the RpoS sigma factor through activation of the stringent response or had mutations suppressing inactivators of RpoS or the stringent response signal-degrading enzyme, SpoT. TolB was inactivated in one mutant: this activates RcsBC regulation and was previously associated with mecillinam resistance. The mechanism of resistance remained unidentified in one mutant. Both the RpoS and RcsBC systems regulate genes of cell division, including ftsAQZ that can compensate for loss or inhibition of PBP2, allowing survival of the challenged bacteria as stable round forms, as seen. WGS identified the global stringent response signal, entailing induction of RpoS, as the main mediator of mutational resistance to OP0595 in E. coli. © The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  4. Prise en charge péri opératoire des urgences chirurgicales abdominales chez l’adulte au CHU Aristide Le Dantec

    PubMed Central

    Gaye, Ibrahima; Leye, Pape Alassane; Traoré, Mamadou Mour; Ndiaye, Pape Ibrahima; Ba, El Hadji Boubacar; Bah, Mamadou Diawo; Fall, Mouhamed Lamine; Diouf, Elisabeth

    2016-01-01

    La prise en charge périopératoire des urgences chirurgicales abdominales reste une préoccupation majeure des anesthésistes du fait des désordres hémodynamiques et/ou métaboliques souvent présents en préopératoire; mais également des complications postopératoires auxquelles elles sont exposées. Les objectifs de ce travail étaient d'étudier les aspects épidémiologiques, diagnostiques, thérapeutiques et pronostiques des urgences abdominales. Etude rétrospective descriptive sur une période de 6 mois portant sur les patients âgés de plus de 16 ans opérés d'une urgence abdominale à l'hôpital Aristide Le Dantec. Les paramètres étudiés portaient sur les aspects épidémiologiques, diagnostiques, thérapeutiques et pronostiques des urgences chirurgicales abdominales. Nous avions colligé 161 cas, près de 20% de l'activité du service. L'âge moyen était de 41 ans [16, 80 ans]. Le sex ratio était de 2, 9. Le délai moyen de consultation était de 4,6 jours. Les péritonites étaient les pathologies les plus fréquentes (25,5%). La fréquence cardiaque moyenne des patients était de 92 bpm (battements/min)et 97 bpm pour ceux ayant eu une préparation hémodynamique préopératoire. La moyenne de la PAM était de 9,66 cmhg et 8,61 cmhg chez les patients préparés. 49,1% des patients étaient de la classe ASA1, 39,9% ASA2, 8,7% ASA3, 2,5% ASA4 et 0,6% ASA5. Une antibioprophylaxie était faite chez 46,30% des patients et 53,41% d'entre eux avaient eu une antibiothérapie.95,6% des patients avaient eu une anesthésie générale et 4,4% une rachianesthésie. La fréquence des incidents peropératoires était de 11,08%. La morbidité était de 4,3% et la mortalité 4,96%. La prise en charge des urgences chirurgicales abdominales doit être multidisciplinaire impliquant anesthésistes, chirurgiens et biologistes afin de réduire davantage le taux de morbimortalité qui reste de nos jours non négligeable. PMID:27795787

  5. CERES Single Scanner Satellite Footprint, TOA, Surface Fluxes and Clouds (SSF) data in HDF (CER_SSF_TRMM-PFM-VIRS_Edition2A-TransOps)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    The Single Scanner Footprint TOA/Surface Fluxes and Clouds (SSF) product contains one hour of instantaneous Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The SSF combines instantaneous CERES data with scene information from a higher-resolution imager such as Visible/Infrared Scanner (VIRS) on TRMM or Moderate-Resolution Imaging Spectroradiometer (MODIS) on Terra and Aqua. Scene identification and cloud properties are defined at the higher imager resolution and these data are averaged over the larger CERES footprint. For each CERES footprint, the SSF contains the number of cloud layers and for each layer the cloud amount, height, temperature, pressure, optical depth, emissivity, ice and liquid water path, and water particle size. The SSF also contains the CERES filtered radiances for the total, shortwave (SW), and window (WN) channels and the unfiltered SW, longwave (LW), and WN radiances. The SW, LW, and WN radiances at spacecraft altitude are converted to Top-of-the-Atmosphere (TOA) fluxes based on the imager defined scene. These TOA fluxes are used to estimate surface fluxes. Only footprints with adequate imager coverage are included on CER_SSF_TRMM-PFM-VIRS_Subset_Edition1the SSF which is much less than the full set of footprints on the CERES ES-8 product. The following CERES SSF data sets are currently available: CER_SSF_TRMM-PFM-VIRS_Edition1 CER_SSF_TRMM-PFM-VIRS_Subset_Edition1 CER_SSF_TRMM-PFM-VIRS_Edition2A CER_SSF_TRMM-SIM-VIRS_Edition2_VIRSonly CER_SSF_TRMM-PFM-VIRS_Edition2A-TransOps CER_SSF_TRMM-PFM-VIRS_Edition2B-TransOps CER_SSF_TRMM-PFM-VIRS_Edition2B CER_SSF_Terra-FM1-MODIS_Edition1A CER_SSF_Terra-FM1-MODIS_Edition1A CER_SSF_Terra-FM1-MODIS_Edition2A CER_SSF_Terra-FM2-MODIS_Edition2A CER_SSF_Terra-FM1-MODIS_Edition2B CER_SSF_Terra-FM2-MODIS_Edition2B CER_SSF_Aqua-FM4-MODIS_Beta1 CER_SSF_Aqua-FM3-MODIS_Beta2 CER_SSF_Aqua-FM4-MODIS_Beta2. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop

  6. Cross-validation of IASI/MetOp derived tropospheric δD with TES and ground-based FTIR observations

    NASA Astrophysics Data System (ADS)

    Lacour, J.-L.; Clarisse, L.; Worden, J.; Schneider, M.; Barthlott, S.; Hase, F.; Risi, C.; Clerbaux, C.; Hurtmans, D.; Coheur, P.-F.

    2015-03-01

    The Infrared Atmospheric Sounding Interferometer (IASI) flying onboard MetOpA and MetOpB is able to capture fine isotopic variations of the HDO to H2O ratio (δD) in the troposphere. Such observations at the high spatio-temporal resolution of the sounder are of great interest to improve our understanding of the mechanisms controlling humidity in the troposphere. In this study we aim to empirically assess the validity of our error estimation previously evaluated theoretically. To achieve this, we compare IASI δD retrieved profiles with other available profiles of δD, from the TES infrared sounder onboard AURA and from three ground-based FTIR stations produced within the MUSICA project: the NDACC (Network for the Detection of Atmospheric Composition Change) sites Kiruna and Izaña, and the TCCON site Karlsruhe, which in addition to near-infrared TCCON spectra also records mid-infrared spectra. We describe the achievable level of agreement between the different retrievals and show that these theoretical errors are in good agreement with empirical differences. The comparisons are made at different locations from tropical to Arctic latitudes, above sea and above land. Generally IASI and TES are similarly sensitive to δD in the free troposphere which allows one to compare their measurements directly. At tropical latitudes where IASI's sensitivity is lower than that of TES, we show that the agreement improves when taking into account the sensitivity of IASI in the TES retrieval. For the comparison IASI-FTIR only direct comparisons are performed because the sensitivity profiles of the two observing systems do not allow to take into account their differences of sensitivity. We identify a quasi negligible bias in the free troposphere (-3‰) between IASI retrieved δD with the TES, which are bias corrected, but important with the ground-based FTIR reaching -47‰. We also suggest that model-satellite observation comparisons could be optimized with IASI thanks to its high

  7. Caractérisation de la flore bactérienne des péritonites communautaires opérées au Burkina Faso

    PubMed Central

    Sanou, Mahamoudou; Ky, Armand; Ouangre, Edgard; Bisseye, Cyrille; Sanou, Adama; Nagalo, Bolni Marius; Sanou, Drissa; Simporé, Jacques; Sangare, Lassana; Traore, Rasmata

    2014-01-01

    Introduction La péritonite communautaire est une urgence chirurgicale récurrente chez l'adulte qui constitue une préoccupation majeure pour le chirurgien et l'anesthésiste-réanimateur dans sa prise en charge. L'objectif de cette étude était d’établir non seulement le profil bactériologique des péritoniques communautaires opérées dans le service de chirurgie générale et digestive du CHU-YO mais aussi d’évaluer la sensibilité aux antibiotiques des souches bactériennes isolées à partir de ces dernières. Méthodes Cent six (106) patients ont été recrutés dans cette étude et des prélèvements bactériologiques préopératoires ont été effectués dont 63 se sont révélés positifs. Résultats Sur les 63 prélèvements positifs, 78 germes ont été isolés soit une moyenne de 1,2 germe par échantillon. Escherichia coli été le germe le plus fréquemment isolé (33,3%), suivi des anaérobies (11,5%), Streptococcus sp (9%), Klebsiella pneumoniae (6,4%) et Staphylococcus sp (5,1%). Les antibiotiques les plus efficaces sur les bactéries identifiées dans les péritonites communautaires étaient respectivement l'imipenème (100%), la colistine (100%), la céftriaxone (100%), et la ciprofloxacine (65,4%) Conclusion Le profil de sensibilité des bactéries identifiées dans les principales péritonites communautaires aux antibiotiques montre une augmentation inquiétante du nombre de souches résistantes, notamment à l'association amoxicilline/acide clavulanique PMID:25360201

  8. Feasibility and Acceptability of Brighter Bites: A Food Co-Op in Schools to Increase Access, Continuity and Education of Fruits and Vegetables Among Low-Income Populations.

    PubMed

    Sharma, Shreela; Helfman, Lisa; Albus, Katherine; Pomeroy, Mike; Chuang, Ru-Jye; Markham, Christine

    2015-08-01

    Intake of fruits and vegetables (F&V) continues to be low in children in the United States. The purpose of this study was to conduct a pilot feasibility evaluation of Brighter Bites, a school-based food co-op to provide access to fresh F&V and nutrition education to low-income children and their families. Brighter Bites is a 16-week school-based food co-op consisting of: (1) Weekly distribution of 50-60 servings of fresh F&V; (2) Weekly bilingual parent handouts and recipe demonstrations; and (3) implementing CATCH, a coordinated school health program in schools. Brighter Bites was pilot tested using a pre-post evaluation design in one charter school in Houston, TX, USA (n = 57 3rd grade parent-child dyads; 94.1 % Hispanic, 91 % low-income). Evaluation, at baseline, midpoint, and post-intervention, included self-reported child and parent surveys on psychosocial factors, dietary habits and mealtime practices. Pearson's Chi square test, Fisher's exact-test or paired t test were used to determine changes pre- to post-intervention (at p < 0.05). Process data using parent surveys, teacher surveys, attendance logs, and produce cost data were used to determine feasibility and acceptability of program. Participants received on average 61 servings of F&V weekly for 16 weeks at the cost of $4.31/family/week. Results showed significant increases in child reported self-efficacy, outcome expectations and attitudes towards consuming F&V (p < 0.05). We found significant increases in child exposure to F&V and child preference of various F&V from baseline to post-intervention (p < 0.05). Parent surveys showed significant improvements in mealtime practices at home: decrease in children eating while watching TV, increase in eating dinner with the family, less fast food, less sugary drinks with meals, more children asking for F&V as snacks. Process data showed 98 % retention rate and high parent acceptability of program components. Brighter Bites is a promising strategy to increase F

  9. La place du traitement non opératoire des contusions abdominales dans les pays en voie de développement

    PubMed Central

    Rabbani, Khalid; Narjis, Youssef; Louzi, Abdelouahed; Benelkhaiat, Redouane; Finech, Benacer

    2015-01-01

    Le traitement non opératoire des contusions de l'abdomen représente une approche thérapeutique nouvelle des traumatismes fermés de l'abdomen. La disponibilité d'un plateau technique performant constitue classiquement une des principales conditions pour la réussite de cette attitude. Nous essayons d’étudier les différents aspects épidémiologiques, diagnostiques et thérapeutiques de cette affection dans le contexte d'un pays en voie de développement, à travers les résultats d'une série de 106 malades. une série de 106 patients est prise en charge par le traitement non opératoire. La gravité des lésions est appréciée par les données cliniques et paracliniques, ainsi que la morbidité et la mortalité sont analysées. les accidents de la circulation étaient la première cause des contusions abdominales, dans notre contexte. Les lésions hépatiques étaient les plus fréquentes (65% des cas), suivit des lésions spléniques chez 19 patients. La notion de polytraumatisme était très fréquente. La durée moyenne de surveillance était de 9,5 jours. Seize malades étaient transfusés, et le nombre moyen de culots globulaires (CG) était de 3,5 culots par patient. Une laparotomie en urgence était indiquée chez 10 patients (9.4%) devant l'instabilité hémodynamique. Trois malades ont nécessité un traitement chirurgical secondaire. On avait noté un taux de mortalité de 3.7% soit 4 cas. il semble à partir de notre expérience que l'abstention chirurgicale peut constituer, dans des conditions strictes de surveillance, une alternative thérapeutique de référence dans les pays en voie de développement, sûre et justifiée à une chirurgie d'urgence toujours difficile. PMID:26097636

  10. OP9 Feeder Cells Are Superior to M2-10B4 Cells for the Generation of Mature and Functional Natural Killer Cells from Umbilical Cord Hematopoietic Progenitors.

    PubMed

    Herrera, Lara; Salcedo, Juan Manuel; Santos, Silvia; Vesga, Miguel Ángel; Borrego, Francisco; Eguizabal, Cristina

    2017-01-01

    Adoptive natural killer (NK) cell therapy relies on the acquisition of large numbers of mature and functional NK cells. An option for future immunotherapy treatments is to use large amounts of NK cells derived and differentiated from umbilical cord blood (UCB) CD34(+) hematopoietic stem cells (HSCs), mainly because UCB is one of the most accessible HSC sources. In our study, we compared the potential of two stromal cell lines, OP9 and M2-10B4, for in vitro generation of mature and functional CD56(+) NK cells from UCB CD34(+) HSC. We generated higher number of CD56(+) NK cells in the presence of the OP9 cell line than when they were generated in the presence of M2-10B4 cells. Furthermore, higher frequency of CD56(+) NK cells was achieved earlier when cultures were performed with the OP9 cells than with the M2-10B4 cells. Additionally, we studied in detail the maturation stages of CD56(+) NK cells during the in vitro differentiation process. Our data show that by using both stromal cell lines, CD34(+) HSC in vitro differentiated into the terminal stages 4-5 of maturation resembled the in vivo differentiation pattern of human NK cells. Higher frequencies of more mature NK cells were reached earlier by using OP9 cell line than M2-10B4 cells. Alternatively, we observed that our in vitro NK cells expressed similar levels of granzyme B and perforin, and there were no significant differences between cultures performed in the presence of OP9 cell line or M2-10B4 cell line. Likewise, degranulation and cytotoxic activity against K562 target cells were very similar in both culture conditions. The results presented here provide an optimal strategy to generate high numbers of mature and functional NK cells in vitro, and point toward the use of the OP9 stromal cell line to accelerate the culture procedure to obtain them. Furthermore, this method could establish the basis for the generation of mature NK cells ready for cancer immunotherapy.

  11. Determination of inverse electric field strength of Ta 218O 5 film produced in biological electrolytes using 18O(p, α) 15N nuclear reaction analysis

    NASA Astrophysics Data System (ADS)

    Wosu, Sylvanus N.

    2005-08-01

    A 18O(p, α) 15N nuclear reaction analysis (NRA) method was developed for the determination of inverse electric field strengths (also referred to as anodic constants) of Ta 2O 5 oxide films prepared in biological solutions (urine, blood plasma and serum). The results show that fresh biological electrolytes have inverse electric field strengths equal to 17.5 ± 1.2, 17.3 ± 1.2, 17.3 ± 0.8 Å/V for plasma, serum and urine, respectively compared to 16.2 ± 0.2 and 15.7 Å/V, for 3% ammonium citrate water and distilled water, respectively. The inverse electric field strength is shown to depend on the pH variation, the metal substrate and the electrolytic ionic concentration. Freezing or aging of the biological sample results in greater variation and reduction of solution pH. Particle-induced X-ray emission (PIXE) and energy dispersive X-ray (EDS) analyses show no incorporation of ions of Z > 11.

  12. Effect of Regional-Scale Transport on Oxidants in the Vicinity of Philadelphia During the 1999 NE-OPS Field Campaign

    SciTech Connect

    Fast, Jerome D.; Zaveri, Rahul A.; Bian, Randy X.; Chapman, Elaine G.; Easter, Richard C.

    2002-08-28

    A new meteorological-chemical modeling system is used to determine the relative contribution of regional-scale transport and local photochemical production on air quality over Philadelphia. The model performance is evaluated using surface and airborne meteorological and chemical measurements made during a 30-day period in July and August of 1999 as part of the Northeast Oxidant and Particulate Study (NE-OPS). Good agreement between the simulations and observations was obtained. The bias in the vicinity of Philadelphia over the simulation period was -5.8 ppb for the peak ozone mixing ratio during the day and 2.0 ppb for the minimum ozone mixing ratio at night. Layers of ozone above the convective boundary layer were measured by both research aircraft and ozonesondes during the morning between 09 and 11 EDT. The modeling system demonstrates that upwind vertical mixing processes the previous afternoon, subsequent horizontal transport aloft, and depletion of ozone by NO titration within the stable boundary layer at night lead to the development of these layers. Ozone aloft was then entrained into the growing convective boundary, contributing to surface ozone concentrations. Through a series of sensitivity studies, we find that most of the ozone is the result of emissions in the vicinity of Philadelphia and Chesapeake Bay area, but up to 30-40% of the ozone during high-ozone episodes was due to transport from upwind sources. Local emissions and meteorological conditions were largely responsible for one high-ozone episode because of light winds.

  13. Isoprene oxidation mechanisms: measurements and modelling of OH and HO2 over a South-East Asian tropical rainforest during the OP3 field campaign

    NASA Astrophysics Data System (ADS)

    Stone, D.; Evans, M. J.; Edwards, P. M.; Commane, R.; Ingham, T.; Rickard, A. R.; Brookes, D. M.; Hopkins, J.; Leigh, R. J.; Lewis, A. C.; Monks, P. S.; Oram, D.; Reeves, C. E.; Stewart, D.; Heard, D. E.

    2011-07-01

    Forests are the dominant source of volatile organic compounds into the atmosphere, with isoprene being the most significant species. The oxidation chemistry of these compounds is a significant driver of local, regional and global atmospheric composition. Observations made over Borneo during the OP3 project in 2008, together with an observationally constrained box model are used to assess our understanding of this oxidation chemistry. In line with previous work in tropical forests, we find that the standard model based on MCM chemistry significantly underestimates the observed OH concentrations. Geometric mean observed to modelled ratios of OH and HO2 in airmasses impacted with isoprene are 5.32-4.43+3.68 and 1.18-0.30+0.30 respectively, with 68 % of the observations being within the specified variation. We implement a variety of mechanistic changes into the model, including epoxide formation and unimolecular decomposition of isoprene peroxy radicals, and assess their impact on the model success. We conclude that none of the current suggestions can simultaneously remove the bias from both OH and HO2 simulations and believe that detailed laboratory studies are now needed to resolve this issue.

  14. Isoprene oxidation mechanisms: measurements and modelling of OH and HO2 over a South-East Asian tropical rainforest during the OP3 field campaign

    NASA Astrophysics Data System (ADS)

    Stone, D.; Evans, M. J.; Edwards, P. M.; Commane, R.; Ingham, T.; Rickard, A. R.; Brookes, D. M.; Hopkins, J.; Leigh, R. J.; Lewis, A. C.; Monks, P. S.; Oram, D.; Reeves, C. E.; Stewart, D.; Heard, D. E.

    2011-03-01

    Forests are the dominant source of volatile organic compounds into the atmosphere, with isoprene being the most significant species. The oxidation chemistry of these compounds is a significant driver of local, regional and global atmospheric composition. Observations made over Borneo during the OP3 project in 2008, together with an observationally constrained box model are used to assess our understanding of this oxidation chemistry. In line with previous work in tropical forests, we find that the standard model based on MCM chemistry significantly underestimates the observed OH concentrations. Geometric mean observed to modelled ratios of OH and HO2 in airmasses impacted with isoprene are 5.32-4.43+3.68 and 1.18-0.30+0.30 respectively, with 68% of the observations being within the specified variation. We implement a variety of mechanistic changes into the model, including epoxide formation and unimolecular decomposition of isoprene peroxy radicals, and assess their impact on the model success. We conclude that none of the current suggestions can simultaneously remove the bias from both OH and HO2 simulations and believe that detailed laboratory studies are now needed to resolve this issue.

  15. Synthesis and characterization of phosphates in molten systems Cs 2O-P 2O 5-CaO- MIII2O 3 ( MIII—Al, Fe, Cr)

    NASA Astrophysics Data System (ADS)

    Zatovsky, Igor V.; Strutynska, Nataliya Yu.; Baumer, Vyacheslav N.; Slobodyanik, Nikolay S.; Ogorodnyk, Ivan V.; Shishkin, Oleg V.

    2011-03-01

    The crystallization of complex phosphates from the melts of Cs 2O-P 2O 5-CaO- MIII2O 3 ( MIII—Al, Fe, Cr) systems have been investigated at fixed value Cs/P molar ratios equal to 0.7, 1.0 and 1.3 and Са/Р=0.2 and Ca/ МIII=1. The fields of crystallization of CsCaP 3O 9, β-Ca 2P 2O 7, Cs 2CaP 2O 7, Cs 3CaFe(P 2O 7) 2, Ca 9MIII(PO 4) 7 ( MIII—Fe, Cr), Cs 0.63Ca 9.63Fe 0.37(PO 4) 7 and CsCa 10(PO 4) 7 were determined. Obtained phosphates were investigated using powder X-ray diffraction and FTIR spectroscopy. Novel whitlockite-related phases CsCa 10(PO 4) 7 and Cs 0.63Ca 9.63Fe 0.37(PO 4) 7 have been characterized by single crystal X-ray diffraction: space group R3c, a=10.5536(5) and 10.5221(4) Å, с=37.2283(19) and 37.2405(17) Å, respectively.

  16. Effect of regional-scale transport on oxidants in the vicinity of Philadelphia during the 1999 NE-OPS field campaign

    NASA Astrophysics Data System (ADS)

    Fast, Jerome D.; Zaveri, Rahul A.; Bian, Xindi; Chapman, Elaine G.; Easter, Richard C.

    2002-08-01

    A new meteorological-chemical model is used to determine the relative contribution of regional-scale transport and local photochemical production on air quality over Philadelphia. The model performance is evaluated using surface and airborne meteorological and chemical measurements made during a 30-day period in July and August of 1999 as part of the Northeast Oxidant and Particulate Study (NE-OPS). Good agreement between the simulations and observations was obtained. The bias in the vicinity of Philadelphia over the simulation period was -5.8 ppb for the peak ozone mixing ratio during the day and 2.0 ppb for the minimum ozone mixing ratio at night. Layers of ozone above the convective boundary layer were measured by both research aircraft and ozonesondes during the morning between 0900 and 1100 LT. The model demonstrates that upwind vertical mixing processes the previous afternoon, subsequent horizontal transport aloft, and depletion of ozone by NO titration within the stable boundary layer at night lead to the development of these layers. Ozone aloft was then entrained into the growing convective boundary, contributing to surface ozone concentrations. Through a series of sensitivity studies, we find that most of the ozone is the result of emissions in the vicinity of Philadelphia and Chesapeake Bay area, but up to 30-40% of the ozone during high ozone episodes was due to transport from upwind sources. Local emissions and meteorological conditions were largely responsible for one high ozone episode because of light winds.

  17. Neutron scattering study on cathode LiMn2O4 and solid electrolyte 5(Li2O)(P2O5)

    NASA Astrophysics Data System (ADS)

    Kartini, E.; Putra, Teguh P.; Jahya, A. K.; Insani, A.; Adams, S.

    2014-09-01

    Neutron scattering is very important technique in order to investigate the energy storage materials such as lithium-ion battery. The unique advantages, neutron can see the light atoms such as Hydrogen, Lithium, and Oxygen, where those elements are negligible by other corresponding X-ray method. On the other hand, the energy storage materials, such as lithium ion battery is very important for the application in the electric vehicles, electronic devices or home appliances. The battery contains electrodes (anode and cathode), and the electrolyte materials. There are many challenging to improve the existing lithium ion battery materials, in order to increase their life time, cyclic ability and also its stability. One of the most scientific challenging is to investigate the crystal structure of both electrode and electrolyte, such as cathodes LiCoO2, LiMn2O4 and LiFePO4, and solid electrolyte Li3PO4. Since all those battery materials contain Lithium ions and Oxygen, the used of neutron scattering techniques to study their structure and related properties are very important and indispensable. This article will review some works of investigating electrodes and electrolytes, LiMn2O4 and 5(Li2O)(P2O5), by using a high resolution powder diffraction (HRPD) at the multipurpose research reactor, RSG-Sywabessy of the National Nuclear Energy Agency (BATAN), Indonesia.

  18. Overview: oxidant and particle photochemical processes above a south-east Asian tropical rainforest (the OP3 project): introduction, rationale, location characteristics and tools

    NASA Astrophysics Data System (ADS)

    Hewitt, C. N.; Lee, J. D.; MacKenzie, A. R.; Barkley, M. P.; Carslaw, N.; Carver, G. D.; Chappell, N. A.; Coe, H.; Collier, C.; Commane, R.; Davies, F.; Davison, B.; Dicarlo, P.; di Marco, C. F.; Dorsey, J. R.; Edwards, P. M.; Evans, M. J.; Fowler, D.; Furneaux, K. L.; Gallagher, M.; Guenther, A.; Heard, D. E.; Helfter, C.; Hopkins, J.; Ingham, T.; Irwin, M.; Jones, C.; Karunaharan, A.; Langford, B.; Lewis, A. C.; Lim, S. F.; MacDonald, S. M.; Mahajan, A. S.; Malpass, S.; McFiggans, G.; Mills, G.; Misztal, P.; Moller, S.; Monks, P. S.; Nemitz, E.; Nicolas-Perea, V.; Oetjen, H.; Oram, D. E.; Palmer, P. I.; Phillips, G. J.; Pike, R.; Plane, J. M. C.; Pugh, T.; Pyle, J. A.; Reeves, C. E.; Robinson, N. H.; Stewart, D.; Stone, D.; Whalley, L. K.; Yin, X.

    2010-01-01

    In April-July 2008, intensive measurements were made of atmospheric composition and chemistry in Sabah, Malaysia, as part of the "Oxidant and particle photochemical processes above a South-East Asian tropical rainforest" (OP3) project. Fluxes and concentrations of trace gases and particles were made from and above the rainforest canopy at the Bukit Atur Global Atmosphere Watch station and at the nearby Sabahmas oil palm plantation, using both ground-based and airborne measurements. Here, the measurement and modelling strategies used, the characteristics of the sites and an overview of data obtained are described. Composition measurements show that the rainforest site was not significantly impacted by anthropogenic pollution, and this is confirmed by satellite retrievals of NO2 and HCHO. The dominant modulators of atmospheric chemistry at the rainforest site were therefore emissions of BVOCs and soil emissions of reactive nitrogen oxides. At the observed BVOC:NOx volume mixing ratio (~100 pptv/pptv), current chemical models suggest that daytime maximum OH concentrations should be ca. 105 radicals cm-3, but observed OH concentrations were an order of magnitude greater than this. We confirm, therefore, previous measurements that suggest that an unexplained source of OH must exist above tropical rainforest and we continue to interrogate the data to find explanations for this.

  19. Oxidant and particle photochemical processes above a south-east Asian tropical rain forest (the OP3 project): introduction, rationale, location characteristics and tools

    NASA Astrophysics Data System (ADS)

    Hewitt, C. N.; Lee, J.; Barkley, M. P.; Carslaw, N.; Chappell, N. A.; Coe, H.; Collier, C.; Commane, R.; Davies, F.; Dicarlo, P.; di Marco, C. F.; Edwards, P. M.; Evans, M. J.; Fowler, D.; Furneaux, K. L.; Gallagher, M.; Guenther, A.; Heard, D. E.; Helfter, C.; Hopkins, J.; Ingham, T.; Irwin, M.; Jones, C.; Karunaharan, A.; Langford, B.; Lewis, A. C.; Lim, S. F.; MacDonald, S. M.; MacKenzie, A. R.; Mahajan, A. S.; Malpass, S.; McFiggans, G.; Mills, G.; Misztal, P.; Moller, S.; Monks, P. S.; Nemitz, E.; Nicolas-Perea, V.; Oetjen, H.; Oram, D.; Palmer, P. I.; Phillips, G. J.; Plane, J. M. C.; Pugh, T.; Pyle, J. A.; Reeves, C. E.; Robinson, N. H.; Stewart, D.; Stone, D.; Whalley, L. K.

    2009-09-01

    In April-July 2008, intensive measurements were made of atmospheric composition and chemistry in Sabah, Malaysia, as part of the "Oxidant and particle photochemical processes above a South-East Asian tropical rain forest" (OP3) project. Fluxes and concentrations of trace gases and particles were made from and above the rain forest canopy at the Bukit Atur Global Atmosphere Watch station and at the nearby Sabahmas oil palm plantation, using both ground-based and airborne measurements. Here, the measurement and modelling strategies used, the characteristics of the sites and an overview of data obtained are described. Composition measurements show that the rainforest site was not impacted by significant sources of anthropogenic pollution, and this is confirmed by satellite retrievals of NO2 and HCHO. The dominant modulators of atmospheric chemistry at the rain forest site were therefore emissions of BVOCs and soil emissions of reactive nitrogen oxides. At the observed BVOC:NOx volume mixing ratio (~104 pptv/pptv), current chemical models suggest that daytime maximum OH concentrations should be ca. 105 radicals cm-3, but observed OH concentrations were an order of magnitude greater than this. We confirm, therefore, previous measurements which suggest that an unexplained source of OH must exist above tropical forests and continue to interrogate the data to find explanations for this.

  20. Prise de remèdes de phytothérapie et implications opératoires: à propos d'un cas

    PubMed Central

    Dhouib, Firas; Frikha, Mohammed; Zineddine, Walid

    2014-01-01

    Les interactions médicamenteuses sont nombreuses et doivent faire l'objet d'une attention particulière à la consultation préanesthésique. Certains médicaments ne sont pas toujours spontanément révélés au médecin anesthésiste. Il s'agit le plus souvent de thérapeutiques dites “non traditionnelles” telle que la phytothérapie, méthode thérapeutique qui utilise l'action des plantes médicinales. On rapporte le cas d'un homme âgé de 38 ans, proposé pour ostéosynthèse d'une fracture des corps vertébraux de D11 et D12, ayant présenté un saignement per opératoire inhabituel rapporté à une consommation de grandes quantités d'ail. PMID:25309668

  1. Randomized controlled trial testing the effectiveness of a depression prevention program ('Op Volle Kracht') among adolescent girls with elevated depressive symptoms.

    PubMed

    Wijnhoven, Lieke A M W; Creemers, Daan H M; Vermulst, Ad A; Scholte, Ron H J; Engels, Rutger C M E

    2014-02-01

    Depression rates rise dramatically from the early to late adolescence. Especially young adolescent girls with elevated depressive symptoms are at high risk for developing a depression during adolescence or adulthood. Therefore, the prevention of depression is important especially in this high-risk group. The aim of the present study was to examine the effectiveness of the Cognitive Behavioral Therapy (CBT) component of the depression prevention program 'Op Volle Kracht' (OVK) among Dutch adolescent girls with elevated depressive symptoms. In total, 102 adolescent girls (11-15 years) in the first and second year of secondary school participated in this study. The girls in the experimental group (n = 50) followed the eight CBT-lessons of OVK and reported depressive symptoms 1 week prior to the start of the lessons, after every lesson, at one-month and 6-months follow-up. The girls in the control group (n = 52) exclusively reported depressive symptoms at the same time points. Latent Growth Curve Modeling showed that the decrease in depressive symptoms was significantly larger for girls in the experimental group compared to the girls in the control group. Furthermore, it was found that at 6-months follow-up, the girls in the experimental group had significantly lower levels of depressive symptoms compared to the girls in the control group. These findings indicate that the CBT-component of OVK effectively reduces depressive symptoms in short term and possibly prevents the development of a clinical depression.

  2. L’érysipèle sur cicatrice post opératoire en traumatologie: à propos d'un cas et revue de la littérature

    PubMed Central

    Abid, Hatim; El Idrissi, Mohamed; Shimi, Mohamed; El Ibrahimi, Abdelhalim; El Mrini, Abdelmajid; Amraoui, Nissrine; Mernissi, Fatima Zohra

    2015-01-01

    L’érysipèle sur cicatrice post opératoire est une entité rare, décrite principalement chez des patients présentant les facteurs de risque classiques de la maladie au niveau des sites de veinectomie pour pontage coronarien. En traumatologie orthopédie, nous n'avons que les 3 cas rapportés dans le travail de Dhrif survenus au décours d'une implantation prothétique chez des malades à risque. Nous présentons à travers cet article, le cas d'un érysipèle post opératoire sur une cicatrice d'ostéosynthèse d'une fracture fermée du pilon tibial, ayant la particularité du terrain et des circonstances de survenues, pour enfin conclure aux principes de la prévention primaire à adopter. PMID:26401204

  3. Comparative analysis of properties of channels of deuteron and tritium production in {sup 16}Op collisions at a projectile momentum of 3.25 GeV/c per nucleon

    SciTech Connect

    Olimov, K.; Glagolev, V. V.; Gulamov, K. G.; Kurbanov, A.; Lutpullaev, S. L.; Olimov, A. K.; Petrov, V. I.; Yuldashev, A. A.

    2014-12-15

    The results of a comparative analysis of channels involving the inclusive production of deuterons and tritons in {sup 16}Op collisions at a projectile momentum of 3.25 GeV/c per nucleon are presented. The mechanisms governing proton, deuteron, and triton production in the fragmentation of oxygen nuclei are found to be independent. It is shown that the observed proton-multiplicity correlations are associated predominantly with the character of the primary event of a proton-nucleon collision in {sup 16}Op interactions. It is found that, in reactions involving triton production, the contributions of processes leading to an increase in the mean proton multiplicity (n → p + π{sup −} and np → pn) and processes leading to its decrease (p → n + π{sup +}) compensate each other.

  4. Microbial Community Analysis in the Roots of Aquatic Plants and Isolation of Novel Microbes Including an Organism of the Candidate Phylum OP10

    PubMed Central

    Tanaka, Yasuhiro; Tamaki, Hideyuki; Matsuzawa, Hiroaki; Nigaya, Masahiro; Mori, Kazuhiro; Kamagata, Yoichi

    2012-01-01

    A number of molecular ecological studies have revealed complex and unique microbial communities in various terrestrial plant roots; however, little is known about the microbial communities of aquatic plant roots in spite of their potential use for water quality improvement in aquatic environments (e.g. floating treatment wetland system). Here, we report the microbial communities inhabiting the roots of emerged plants, reed (Phragmites australis) and Japanese loosestrife (Lythrum anceps), collected from a floating treatment wetland in a pond by both culture-independent and culture-dependent approaches. Culture-independent analysis based on 16S rRNA gene sequences revealed that the microbial compositions between the two aquatic plant roots were clearly different (e.g. the predominant microbe was Betaproteobacteria for reed and Alphaproteobacteria for Japanese loosestrife). In comparisons of microbial communities between the plant roots and pond water taken from near the plants, the microbial diversity in the plant roots (e.g. 4.40–4.26 Shannon-Weiner index) were higher than that of pond water (e.g. 3.15 Shannon-Weiner index). Furthermore, the plant roots harbored 2.5–3.5 times more phylogenetically novel clone phylotypes than pond water. The culture-dependent approach also revealed differences in the microbial composition and diversity among the two plant roots and pond water. More importantly, compared to pond water, we succeeded in isolating approximately two times more novel isolate phylotypes, including a bacterium of candidate phylum OP10 (recently named Armatimonadetes) from the plant roots. These findings suggest that aquatic plants roots are significant sources for a variety of novel organisms. PMID:22791047

  5. A randomized controlled trial testing the effectiveness of a universal school-based depression prevention program 'Op Volle Kracht' in the Netherlands.

    PubMed

    Tak, Yuli R; Van Zundert, Rinka Mp; Kuijpers, Rowella Cwm; Van Vlokhoven, Boukje S; Rensink, Hettie Fw; Engels, Rutger Cme

    2012-01-10

    The incidence of depressive symptoms increases during adolescence, from 10.0% to 24.5% at age 11 to 15, respectively. Experiencing elevated levels of depressive symptoms increases the risk of a depressive disorder in adulthood. A universal school-based depression prevention program Op Volle Kracht (OVK) was developed, based on the Penn Resiliency Program, aimed at preventing the increase of depressive symptoms during adolescence and enhancing positive development. In this study the effectiveness of OVK will be tested and possible mediators of program effects will be focus of study as well. The effectiveness of OVK will be tested in a randomized controlled trial with two conditions, intervention (OVK) and control condition (care as usual). Schools are randomly assigned to research conditions. OVK will be incorporated in the school curriculum, maximizing program attendance. OVK consists of 16 lessons of 50 min, given by trained psychologists to groups of 11-15 students. OVK contains Cognitive Behavioral Therapy, social skills training, problem solving and decision making. Outcomes are measured at 6, 12, 18 and 24 months follow up, to monitor long term program effects. Primary outcome is level of depressive symptoms, secondary outcomes are: anxiety, hopelessness, cognitive bias, substance use, truancy, life satisfaction, coping, self-efficacy, optimism, happiness, friendship, school performance and school attitude. The questionnaires for students will be administered in the school setting. Parents will complete a questionnaire at baseline only. In this paper the study into the effectiveness of the depression prevention program OVK was described. It is expected that OVK will prevent the increase in depressive symptoms during adolescence and enhance positive development in the intervention condition, compared to the control condition. If OVK will be effective, it can be implemented in the school context by which numerous adolescents can be reached. Netherlands Trial

  6. Magnetic polyoxometalates: anisotropic exchange interactions in the moiety of [(NaOH2)Co3(H2O)(P2W15O56)2]17-.

    PubMed

    Clemente-Juan, Juan Modesto; Coronado, Eugenio; Gaita-Ariño, Alejandro; Giménez-Saiz, Carlos; Güdel, Hans-Ulrich; Sieber, Andreas; Bircher, Roland; Mutka, Hannu

    2005-05-16

    The magnetic exchange interactions in a C0(3)(11) moiety encapsulated in Na(17) [(NaOH(2))Co(3)(H(2)O)(P(2)W(15)O(56))(2)] (NaCo(3)) were studied by a combination of magnetic measurements (magnetic susceptibility and low-temperature magnetization), with a detailed Inelastic Neutron Scattering (INS) investigation. The novel structure of the salt was determined by X-ray crystallography. The ferromagnetic Co(3)O(14) triangular cluster core consists of three octahedrally oxo-coordinated Co(II) ions sharing edges. According to the single-ion anisotropy and spin-orbit coupling usually assumed for octahedral Co(II) ions, the appropiate exchange Hamiltonian to describe the ground-state properties of the isosceles triangular Co(3) spin cluster is anisotropic and is expressed as H = - 2sigma(alpha)(=)(x,y,z)(J(alpha)(12)S(1alpha)S(2alpha) + J(alpha)(23)S(2alpha)S(3alpha) + J(alpha)(13)S(1alpha)S(3alpha)), where J(alpha) are the components of the exchange interactions between the Co(II) ions. To reproduce the INS data, nonparallel anisotropic exchange tensors needed to be introduced, which were directly connected to the molecular symmetry of the complex. The following range of parameters (value +/- 0.5 cm(-1)) was found to reproduce all experimental information while taking magnetostructural relations into account: J(x)(12) = J(y)(13) = 8.6 cm(-1); J(y)(12) = J(x)(13) = 1.4 cm(-1); J(z)(12) = J(z)(13) = 10.0 cm(-1); J(x)(23) = J(y)(23) = 6.5 cm(-1) and = 3.4 cm(-1).

  7. Distributions of δD observations from IASI/MetOp across the globe and intercomparison with other instruments/measurements

    NASA Astrophysics Data System (ADS)

    Lacour, Jean-Lionel; Clarisse, Lieven; Hurtmans, Daniel; Clerbaux, Cathy; Worden, John; Schneider, Matthias; Risi, Camille; Coheur, Pierre-François

    2014-05-01

    The Infrared Atmospheric Sounding Interferometer (IASI) onboard MetOp, through its observations of the water isotopologues, has great potential to support research on hydrological processes responsible for the moistening/drying of the atmosphere. The instrumental characteristics of the spectrometer (low radiometric noise and good spectral resolution) combined with its high sampling (global coverage twice a day) make it particularly suitable for providing numerous observations of the isotopologues ratio (δD) of water vapour in the troposphere. Retrieving isotopologues ratios at the required accuracy is, however, a challenging task. To get meaningful results, the retrieval needs to be well constrained. This can be achieved, with the optimal estimation method, by using an a priori probability density function containing correlation information between HDO and H2O. In this presentation, first, we will show that the measurements are mainly sensitive to δD in the troposphere between 3 and 6 km. We will illustrate the capabilities of IASI to provide δD observations at high spatio-temporal resolution with some distributions across the globe and we will discuss their added values to constrain hydrological processes. Second, we will document how IASI observations compare to other remote sounding observations of δD in the troposphere. Comparisons of IASI observations with the TES sounder and with three ground-based NDACC FTIR (Izaña, Kalsruhe and Kiruna, data generated within the project MUSICA) will be presented. The differences between the instruments as well as the methodology to compare them will be exposed. We will show that the different instruments agree within their own uncertainties and vertical sensitivities, asserting the use of IASI δD observations for scientific purposes.

  8. OpTIIX: An ISS-Based Testbed Paving the Roadmap Toward a Next Generation Large Aperture UV/Optical Space Telescope

    NASA Technical Reports Server (NTRS)

    Carpenter, Kenneth G.; Etemad, Shar; Seery, Bernard D.; Thronson, Harley; Burdick, Gary M.; Coulter, Dan; Goullioud, Renaud; Green, Joseph J.; Liu, Fengchuan; Ess, Kim; Postman, Marc; Sparks, Williams

    2012-01-01

    The next generation large aperture UV/Optical space telescope will need a diameter substantially larger than even that of JWST in order to address some of the most compelling unanswered scientific quests. These quests include understanding the earliest phases of the Universe and detecting life on exo-planets by studying spectra of their atmospheres. Such 8-16 meter telescopes face severe challenges in terms of cost and complexity and are unlikely to be affordable unless a new paradigm is adopted for their design and construction. The conventional approach is to use monolithic or preassembled segmented mirrors requiring complicated and risky deployments and relying on future heavy-lift vehicles, large fairings and complex geometry. The new paradigm is to launch component modules on relatively small vehicles and then perform in-orbit robotic assembly of those modules. The Optical Testbed and Integration on ISS eXperiment (OpTIIX) is designed to demonstrate, at low cost by leveraging the infrastructure provided by ISS, telescope assembly technologies and end-to-end optical system technologies. The use of ISS as a testbed permits the concentration of resources on reducing the technical risks associated with robotically integrating the components. These include laser metrology and wavefront sensing and control (WFS&C) systems, an imaging instrument, lightweight, low-cost deformable primary mirror segments and the secondary mirror. These elements are then aligned to a diffraction-limited optical system in space. The capability to assemble the optical system and remove and replace components via the existing ISS robotic systems like the Special Purpose Dexterous Manipulator (SPDM), or by the ISS flight crew, allows for future experimentation, as well as repair.

  9. Data Fusion Approaches to Close the Spatial and Temporal Scale Gaps between MetOp-ASCAT and Sentinel-1 Soil Moisture Observations

    NASA Astrophysics Data System (ADS)

    Bauer-Marschallinger, Bernhard; Mistelbauer, Thomas; Hochstöger, Simon; Paulik, Christoph; Wagner, Wolfgang

    2016-04-01

    Earth observation (EO), and more specifically, spaceborne radar remote sensing had made much progress toward its high potential to retrieve Soil Moisture (SM) at different scales. Yet, for a single sensing system there always exists a trade-off between spatial and temporal resolution of the observations: While scatterometer-derived SM products can well describe temporal soil moisture dynamics, they lack of spatial details. They do not facilitate analysis of local hydrological patterns, such as effects from convectional rains and topography and thus miss the requirements of many users. Contrary, SM products from Synthetic Aperture Radar (SAR) sensors can resolve dynamics at this level. However, they observe individual locations less frequently and are thus not suitable for acquisition of short-term variations. To overcome these spatial and temporal scale gaps, data fusion of C-Band scatterometer and SAR radar observations is the method of choice, yielding a high-resolution, high-frequency soil profile wetness product called SCAT-SAR Soil Water Index (SWI). Benefiting from the input's either high temporal or spatial resolution, respectively, this 500m-sampling product bears great potential for operational use, even at local scale. In this study, different approaches to fuse MetOp ASCAT scatterometer data (12.5km and almost-daily sampling) with SAR data from the new Sentinel-1 (10m and 3-6-day sampling) are examined. Methods entailed in the fusion process comprise spatial resampling, spatial correlation analysis, data matching, temporal matching and filtering as well as signal-to-noise estimation. Different sets of methods for data fusion are employed for SM derivation. The results are evaluated against alone-standing ASCAT and Sentinel-1 SM data, as well as against in-situ measurements at the Hydrological Open Air Laboratory (HOAL) in Petzenkirchen, Lower Austria.

  10. CO Seasonal Variability and Trend over Paris Megacity Using Ground-Based QualAir FTS and Satellite IASI-MetOp Measurements

    NASA Astrophysics Data System (ADS)

    Te, Yao; Jeseck, Pascal; Hadji-Lazaro, Juliette

    2012-11-01

    In a growing world with more than 7 billion inhabitants and big emerging countries such as China, Brazil and India, emissions of anthropogenic pollutants are increasing continuously. Monitoring and control of atmospheric pollutants in megacities have become a major challenge for scientists and public health authorities in environmental research area. The QualAir platform at University Pierre et Marie Curie (UPMC), is an innovating experimental research platform dedicated to survey urban atmospheric pollution and air quality. A Bruker Optics IFS 125HR Fourier transform spectrometer belonged to the Laboratoire de Physique Moléculaire pour l'Atmosphère et l'Astrophysique (LPMAA), was adapted for ground-based atmospheric measurements. As one of the major instruments of the QualAir platform, this ground-based Fourier transform spectrometer (QualAir FTS) analyses the composition of the urban atmosphere of Paris, which is the third largest European megacity. The continuous monitoring of atmospheric pollutants is essential to improve the understanding of urban air pollution processes. Associated with a sun-tracker, the QualAir remote sensing FTS operates in solar infrared absorption and enables to monitor many trace gases, and to follow up their variability in the Ile-de-France region. Concentrations of atmospheric pollutants are retrieved by the radiative transfer model PROFFIT. These ground-based remote sensing measurements are compared to ground in-situ measurements and to satellite data from IASI-MetOp (Infrared Atmospheric Sounding Interferometer). The remote sensing total column of the carbon monoxide (CO) obtained from January 2009 to June 2012, has a seasonal variability with a maximum in April and a minimum in October. While, after 2008, the mean CO level is quite stable (no significant decrease as before 2008).

  11. Physiological and psychological effects of testosterone during severe energy deficit and recovery: A study protocol for a randomized, placebo-controlled trial for Optimizing Performance for Soldiers (OPS).

    PubMed

    Pasiakos, Stefan M; Berryman, Claire E; Karl, J Philip; Lieberman, Harris R; Orr, Jeb S; Margolis, Lee M; Caldwell, John A; Young, Andrew J; Montano, Monty A; Evans, William J; Vartanian, Oshin; Carmichael, Owen T; Gadde, Kishore M; Harris, Melissa; Rood, Jennifer C

    2017-07-01

    The physiological consequences of severe energy deficit include hypogonadism and the loss of fat-free mass. Prolonged energy deficit also impacts physical performance, mood, attentiveness, and decision-making capabilities. This study will determine whether maintaining a eugonadal state during severe, sustained energy deficit attenuates physiological decrements and maintains mental performance. This study will also assess the effects of normalizing testosterone levels during severe energy deficit and recovery on gut health and appetite regulation. Fifty physically active men will participate in a 3-phase, randomized, placebo-controlled study. After completing a 14-d, energy-adequate, diet acclimation phase (protein: 1.6g∙kg(-1)∙d(-1); fat: 30% total energy intake), participants will be randomized to undergo a 28-d, 55% energy deficit phase with (DEF+TEST: 200mg testosterone enanthate per week) or without (DEF) exogenous testosterone. Diet and physical activity will be rigorously controlled. Recovery from the energy deficit (ad libitum diet, no testosterone) will be assessed until body mass has been recovered within ±2.5% of initial body mass. Body composition, stable isotope methodologies, proteomics, muscle biopsies, whole-room calorimetry, molecular biology, activity/sleep monitoring, personality and cognitive function assessments, functional MRI, and comprehensive biochemistries will be used to assess physiological and psychological responses to energy restriction and recovery feeding while volunteers are in an expected hypogonadal versus eugonadal state. The Optimizing Performance for Soldiers (OPS) study aims to determine whether preventing hypogonadism will mitigate declines in physical and mental function that typically occur during prolonged energy deficit, and the efficacy of testosterone replacement on recovery from severe underfeeding. NCT02734238. Copyright © 2017. Published by Elsevier Inc.

  12. Comparison of total water vapor column from GOME-2 on MetOp-A against ground-based GPS measurements at the Iberian Peninsula.

    PubMed

    Román, R; Antón, M; Cachorro, V E; Loyola, D; Ortiz de Galisteo, J P; de Frutos, A; Romero-Campos, P M

    2015-11-15

    Water vapor column (WVC) obtained by GOME-2 instrument (GDP-4.6 version) onboard MetOp-A satellite platform is compared against reference WVC values derived from GPS (Global Positioning System) instruments from 2007 to 2012 at 21 places located at Iberian Peninsula. The accuracy and precision of GOME-2 to estimate the WVC is studied for different Iberian Peninsula zones using the mean (MBE) and the standard deviation (SD) of the GOME-2 and GPS differences. A direct comparison of all available data shows an overestimation of GOME-2 compared to GPS with a MBE of 0.7 mm (10%) and a precision quantified by a SD equals to 4.4mm (31%). South-Western zone presents the highest overestimation with a MBE of 1.9 mm (17%), while Continental zone shows the lowest SD absolute value (3.3mm) due mainly to the low WVC values reached at this zone. The influence of solar zenith angle (SZA), cloud fraction (CF), and the type of surface and its albedo on the differences between GOME-2 and GPS is analyzed in detail. MBE and SD increase when SZA increases, but MBE decreases (taking negative values) when CF increases and SD shows no significant dependence on CF. Under cloud-free conditions, the differences between WVC from GOME-2 and GPS are within the WVC error given by GOME-2. The changes of MBE and SD on Surface Albedo are not so evident, but MBE slightly decreases when the Surface Albedo increases. WVC from GOME-2 is, in general, more precise for land than for sea pixels.

  13. Microbial community analysis in the roots of aquatic plants and isolation of novel microbes including an organism of the candidate phylum OP10.

    PubMed

    Tanaka, Yasuhiro; Tamaki, Hideyuki; Matsuzawa, Hiroaki; Nigaya, Masahiro; Mori, Kazuhiro; Kamagata, Yoichi

    2012-01-01

    A number of molecular ecological studies have revealed complex and unique microbial communities in various terrestrial plant roots; however, little is known about the microbial communities of aquatic plant roots in spite of their potential use for water quality improvement in aquatic environments (e.g. floating treatment wetland system). Here, we report the microbial communities inhabiting the roots of emerged plants, reed (Phragmites australis) and Japanese loosestrife (Lythrum anceps), collected from a floating treatment wetland in a pond by both culture-independent and culture-dependent approaches. Culture-independent analysis based on 16S rRNA gene sequences revealed that the microbial compositions between the two aquatic plant roots were clearly different (e.g. the predominant microbe was Betaproteobacteria for reed and Alphaproteobacteria for Japanese loosestrife). In comparisons of microbial communities between the plant roots and pond water taken from near the plants, the microbial diversity in the plant roots (e.g. 4.40-4.26 Shannon-Weiner index) were higher than that of pond water (e.g. 3.15 Shannon-Weiner index). Furthermore, the plant roots harbored 2.5-3.5 times more phylogenetically novel clone phylotypes than pond water. The culture-dependent approach also revealed differences in the microbial composition and diversity among the two plant roots and pond water. More importantly, compared to pond water, we succeeded in isolating approximately two times more novel isolate phylotypes, including a bacterium of candidate phylum OP10 (recently named Armatimonadetes) from the plant roots. These findings suggest that aquatic plants roots are significant sources for a variety of novel organisms.

  14. Inhibition of terminal chondrocyte differentiation by bone morphogenetic protein 7 (OP-1) in vitro depends on the periarticular region but is independent of parathyroid hormone-related peptide.

    PubMed

    Haaijman, A; Karperien, M; Lanske, B; Hendriks, J; Löwik, C W; Bronckers, A L; Burger, E H

    1999-10-01

    Bone morphogenetic protein-7, or BMP-7 (OP-1), is highly expressed in the perichondrium of embryonic long bones and is thought to play a role in endochondral ossification. Previously we have shown that BMP-7 inhibits terminal chondrocyte differentiation; that is, chondrocyte hypertrophy and mineralization in cultured explants of embryonic mouse metatarsals. However, the mechanism of this inhibition and the target cells of BMP-7 are still unknown. In this study we show that BMP-7 inhibits terminal chondrocyte differentiation indirectly, via an interaction with the periarticular region of the explants. This region also expresses parathyroid hormone-related peptide (PTHrP). PTHrP regulates terminal chondrocyte differentiation by inhibiting hypertrophic differentiation of prehypertrophic chondrocytes. The differentiating center in turn regulates PTHrP expression via a feedback loop involving Indian hedgehog (Ihh), which is expressed in the prehypertrophic chondrocytes. Ihh is thought to act on perichondrial cells, which in turn start to express an as yet unknown mediator that stimulates PTHrP expression in the periarticular region. It has been suggested that this factor belongs to the BMP-family. We investigated whether the inhibition of terminal chondrocyte differentiation by BMP-7 was due to upregulation of the PTHrP-Ihh feedback loop and whether BMP-7 was the unknown factor in the loop. Here we show that exogenous BMP-7 did not upregulate the mRNA expression of PTHrP, Ihh, or the PTH/PTHrP receptor in cultured wild-type embryonic metatarsals. Furthermore, BMP-7 could still inhibit terminal chondrocyte differentiation in the metatarsals of PTHrP-deficient (PTHrP-/-) mouse embryos. These data indicate that the BMP-7-mediated inhibition of terminal chondrocyte differentiation in vitro is independent of the PTHrP-Ihh feedback loop. We concluded that BMP-7 modulates terminal chondrocyte differentiation and cartilage mineralization of fetal bone explants in vitro via as

  15. Cyberspace Mission Focus: NW Ops vs. NetOps

    DTIC Science & Technology

    2010-06-01

    backgrounds and perspectives we have shared , argued and often laughed that I will look back on this experience with fond memories. It has been a blast... risk (amount of uncertainty/vulnerability commanders are willing to accept) and combining them with operational level effects for the purpose of...example, brings increased risk of detection for certain types of special operations air missions and those missions will typically not be flown at times

  16. Evénements indésirables peropératoire: lecture critique du registre du bloc opératoire de l’hôpital militaire Moulay Ismail Meknès

    PubMed Central

    Kechna, Hicham; Ouzzad, Omar; Chkoura, Khalid; Loutid, Jaouad; Hachimi, Moulay Ahmed; Hanafi, Sidi Mohamed

    2016-01-01

    Introduction Malgré les importants progrès qui ont été faits dans le domaine de la sécurité en anesthésie, la morbidité (grave ou non, liée complètement ou partiellement à l’anesthésie) reste cependant fréquente, et aucun praticien n’est aujourd’hui à l’abri d’un accident. Dans le contexte actuel où la priorité est donnée à la formation, à l’amélioration de la qualité et de la sécurité des soins, la survenue d’un accident d’anesthésie au bloc opératoire est un événement extrêmement traumatisant. La crainte de poursuite, le contexte émotionnel rendent cette gestion parfois très difficile. Pour cette raison, elle doit faire l’objet d’une codification, à la manière des protocoles de bloc, avec trois grands axes de gestion: le patient victime, le personnel médical et paramédical impliqué et l’analyse de l’incident pour éviter une récidive. Méthodes Dans un but d’améliorer les soins prodigués au bloc opératoire nous avons établi un registre où sont consignés continuellement les différents incidents et accidents survenu soit en salle opératoire ou en salle de surveillance post interventionnelle. Une première lecture a été faite à l’occasion des Journées d'Enseignement Post Universitaire (JEPU) de Fès (Maroc) organisées en partenariat avec les JEPU de la Pitié salpêtrière de Paris à la faculté de Médecine et de Pharmacie de Fès sous le thème: «Les Situations Critiques Au Bloc Opératoire» les 17 et 18 Avril 2015. Résultats 1761 patients ont été admis aux différentes salles du bloc opératoire dont 96 en salle d’endoscopie et 17 sédations en radiologie. 29 patients (1.64%) ont présentés un incident et/ou un accident en péri opératoire. La plupart des effets indésirables sont survenus en per opératoire (58,6%). Dans 28,6% des cas en postopératoire immédiat ou en salle de surveillance post interventionnelle (SSPI). La plupart des complications survenues sont d

  17. Suited Contingency Ops Food - 2

    NASA Technical Reports Server (NTRS)

    Glass, J. W.; Leong, M. L.; Douglas, G. L.

    2014-01-01

    The contingency scenario for an emergency cabin depressurization event may require crewmembers to subsist in a pressurized suit for up to 144 hours. This scenario requires the capability for safe nutrition delivery through a helmet feed port against a 4 psi pressure differential to enable crewmembers to maintain strength and cognition to perform critical tasks. Two nutritional delivery prototypes were developed and analyzed for compatibility with the helmet feed port interface and for operational effectiveness against the pressure differential. The bag-in-bag (BiB) prototype, designed to equalize the suit pressure with the beverage pouch and enable a crewmember to drink normally, delivered water successfully to three different subjects in suits pressurized to 4 psi. The Boa restrainer pouch, designed to provide mechanical leverage to overcome the pressure differential, did not operate sufficiently. Guidelines were developed and compiled for contingency beverages that provide macro-nutritional requirements, a minimum one-year shelf life, and compatibility with the delivery hardware. Evaluation results and food product parameters have the potential to be used to improve future prototype designs and develop complete nutritional beverages for contingency events. These feeding capabilities would have additional use on extended surface mission EVAs, where the current in-suit drinking device may be insufficient.

  18. Intelligent Systems Technologies for Ops

    NASA Technical Reports Server (NTRS)

    Smith, Ernest E.; Korsmeyer, David J.

    2012-01-01

    As NASA supports International Space Station assembly complete operations through 2020 (or later) and prepares for future human exploration programs, there is additional emphasis in the manned spaceflight program to find more efficient and effective ways of providing the ground-based mission support. Since 2006 this search for improvement has led to a significant cross-fertilization between the NASA advanced software development community and the manned spaceflight operations community. A variety of mission operations systems and tools have been developed over the past decades as NASA has operated the Mars robotic missions, the Space Shuttle, and the International Space Station. NASA Ames Research Center has been developing and applying its advanced intelligent systems research to mission operations tools for both unmanned Mars missions operations since 2001 and to manned operations with NASA Johnson Space Center since 2006. In particular, the fundamental advanced software development work under the Exploration Technology Program, and the experience and capabilities developed for mission operations systems for the Mars surface missions, (Spirit/Opportunity, Phoenix Lander, and MSL) have enhanced the development and application of advanced mission operation systems for the International Space Station and future spacecraft. This paper provides an update on the status of the development and deployment of a variety of intelligent systems technologies adopted for manned mission operations, and some discussion of the planned work for Autonomous Mission Operations in future human exploration. We discuss several specific projects between the Ames Research Center and the Johnson Space Centers Mission Operations Directorate, and how these technologies and projects are enhancing the mission operations support for the International Space Station, and supporting the current Autonomous Mission Operations Project for the mission operation support of the future human exploration programs.

  19. S6 Truss Grapple OPS

    NASA Image and Video Library

    2009-03-18

    ISS018-E-040973 (18 March 2009) --- This scene gives evidence that the "work crews" have arrived at the International Space Station to continue the "home improvement" project. A Soyuz vehicle used to transport the station crewmembers is in the foreground, with the Space Shuttle Discovery visible just beneath it. Ten people are busy on the station, and two of them are preparing to exit the shirt sleeve environment to go outside for a March 19 spacewalk, on which the other crewmembers will be pitching in their support and technical assistance.

  20. The CO-OP Twist

    ERIC Educational Resources Information Center

    Polatajko, Helene J.

    2010-01-01

    In this article, the author comments on the article by Sylvia Rodger and Alysha Vishram appearing in this issue, titled "Mastering Social and Organizational Goals: Strategy Use by Two Children with Asperger Syndrome during Cognitive Orientation to Daily Occupational Performance." In the article, the authors explore the use of cognitive strategies,…

  1. Combining Ambient Measurements of OH Radicals and OH Reactivity in a Tropical Rainforest during the OP-3 Project: Resolving the Magnitude of the Missing OH Sources and Sinks

    NASA Astrophysics Data System (ADS)

    Whalley, L. K.; Edwards, P.; Furneaux, K. L.; Goddard, A.; George, I. J.; Evans, M. J.; Heard, D. E.; Team Op-3

    2010-12-01

    The self cleansing capacity of the troposphere and the lifetime of key greenhouse gases are controlled to a large extent by the OH radical. In environments where biogenic VOC emissions are high and NOx concentrations are low, for example in tropical rainforests, the current understanding of tropospheric chemistry suggests that OH radical concentrations should be suppressed. OH measurements made in such regions, however, have highlighted higher than expected OH radical concentrations that cannot be replicated by chemical models constrained with the currently known OH formation pathways [1]. Here we report OH and OH reactivity measurements made during the OP-3 project that took place in the Borneo rainforest in 2008. Concentrations of OH displayed a clear diurnal cycle, peaking at solar noon, with significant concentrations observed: up to 8.7×106 molecule cm-3 (60 min average). Although j(O1D) levels and humidity were high, low O3 concentrations limited the rate of primary OH production from ozone photolysis. OH reactivity measurements were made using a sliding injector flow-tube reactor technique, with OH detection by LIF. Mean OH reactivities of 15.5 s-1 were observed with daily maximum OH reactivity of 24.7 ± 11.1 s-1 shortly after local solar noon, coinciding with peak isoprene concentrations. Minimum values of 7.2 ± 2.2 s-1 were observed just before sun rise. Using the measured OH and OH reactivity in a constrained box model containing detailed MCM chemistry we are able to fully resolve the magnitude of the missing OH source. We find that significant OH sources must be present - in addition to primary production - in order to maintain the elevated levels of OH levels recorded. Inclusion of an additional OH source formed as a recycled product of isoprene oxidation [2] improves the modelled OH agreement but reduces the modelled to measured HO2 agreement. To replicate both OH and HO2, a process that recycles HO2 to OH is required; equivalent to the OH recycling

  2. Comparison of CO2 total column retrieved from IASI/MetOp-A using KLIMA algorithm and TANSO-FTS/GOSAT level 2 products

    NASA Astrophysics Data System (ADS)

    Laurenza, Lucia Maria; Cortesi, Ugo; DelBianco, Samuele; Gai, Marco

    2013-04-01

    Carbon dioxide is a key constituent of the terrestrial atmosphere with both natural and anthropogenic sources. It is one of the primary forcing agents of the greenhouse effect, as well as from being the most mobile component of the global carbon cycle that is critically coupled to the Earth's climate system. In this study, one year of observations from the Infrared Atmospheric Sounding Interferometer (IASI), onboard of MetOp-A satellite, are used to retrieve the columnar abundance of atmospheric carbon dioxide, for a global geographical coverage and in clear-sky conditions. The dedicated software is based on the KLIMA inversion algorithm (originally proposed by IFAC-CNR for cycle 6 of ESA Earth Explorer Core Missions) and has been adapted into a non-operational inversion code to process Level-1 data acquired by the IASI instrument and to retrieve the CO2 total column with a target accuracy of 1%. In order to obtain the a reasonable capacity to bulk processing IASI data, it was chosen to integrate the KLIMA code into the ESA grid based operational environment G-POD system (Grid Processing On-Demand). A series of approximations has been implemented in the radiative transfer code with the aim to achieve adequate features in term of program size and computing time necessary for the integration into G-POD system and to meet the requirements of comparison with TANSO-FTS/GOSAT SWIR Level-2 products. The KLIMA-IASI retrieval code integration on G-POD has been completed and considering the capacity of G-POD computing resources, it was decided to process, for global geographical coverage, one week per month of a complete year of IASI measurements, from March 1, 2010 to February 28, 2011. In this selected temporal range, TANSO-FTS SWIR Level-2 data were obtained from the GOSAT User Interface Gateway (GUIG), and data from selected stations covers a different latitudes of the Total Carbon Column Observing Network (TCCON) were collected from TCCON Data Archive. We performed an

  3. Evaluating a new homogeneous total ozone climate data record from GOME/ERS-2, SCIAMACHY/Envisat, and GOME-2/MetOp-A

    NASA Astrophysics Data System (ADS)

    Koukouli, M. E.; Lerot, C.; Granville, J.; Goutail, F.; Lambert, J.-C.; Pommereau, J.-P.; Balis, D.; Zyrichidou, I.; Van Roozendael, M.; Coldewey-Egbers, M.; Loyola, D.; Labow, G.; Frith, S.; Spurr, R.; Zehner, C.

    2015-12-01

    The European Space Agency's Ozone Climate Change Initiative (O3-CCI) project aims at producing and validating a number of high-quality ozone data products generated from different satellite sensors. For total ozone, the O3-CCI approach consists of minimizing sources of bias and systematic uncertainties by applying a common retrieval algorithm to all level 1 data sets, in order to enhance the consistency between the level 2 data sets from individual sensors. Here we present the evaluation of the total ozone products from the European sensors Global Ozone Monitoring Experiment (GOME)/ERS-2, SCIAMACHY/Envisat, and GOME-2/MetOp-A produced with the GOME-type Direct FITting (GODFIT) algorithm v3. Measurements from the three sensors span more than 16 years, from 1996 to 2012. In this work, we present the latest O3-CCI total ozone validation results using as reference ground-based measurements from Brewer and Dobson spectrophotometers archived at the World Ozone and UV Data Centre of the World Meteorological Organization as well as from UV-visible differential optical absorption spectroscopy (DOAS)/Système D'Analyse par Observations Zénithales (SAOZ) instruments from the Network for the Detection of Atmospheric Composition Change. In particular, we investigate possible dependencies in these new GODFIT v3 total ozone data sets with respect to latitude, season, solar zenith angle, and different cloud parameters, using the most adequate type of ground-based instrument. We show that these three O3-CCI total ozone data products behave very similarly and are less sensitive to instrumental degradation, mainly as a result of the new reflectance soft-calibration scheme. The mean bias to the ground-based observations is found to be within the 1 ± 1% level for all three sensors while the near-zero decadal stability of the total ozone columns (TOCs) provided by the three European instruments falls well within the 1-3% requirement of the European Space Agency's Ozone Climate Change

  4. CERES ERBE-like Instantaneous TOA Estimates (ES-8) in HDF (CER_ES8_TRMM-PFM_Transient-Ops2)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    The ES-8 archival data product contains a 24-hour, single-satellite, instantaneous view of scanner fluxes at the top-of-atmosphere (TOA) reduced from spacecraft altitude unfiltered radiances using Earth Radiation Budget Experiment (ERBE) scanner Inversion algorithms and the ERBE shortwave (SW) and longwave (LW) Angular Distribution Models (ADMs). The ES-8 also includes the total (TOT), SW, LW, and window (WN) channel radiometric data; SW, LW, and WN unfiltered radiance values; and the ERBE scene identification for each measurement. These data are organized according to the CERES 3.3-second scan into 6.6-second records. As long as there is one valid scanner measurement within a record, the ES-8 record will be generated. The following CERES ES8 data sets are currently available: CER_ES8_TRMM-PFM_Edition1 CER_ES8_TRMM-PFM_Edition2 CER_ES8_TRMM-PFM_Transient-Ops2 CER_ES8_Terra-FM1_Edition1 CER_ES8_Terra-FM2_Edition1 CER_ES8_Terra-FM1_Edition2 CER_ES8_Terra-FM2_Edition2 CER_ES8_Aqua-FM3_Edition1 CER_ES8_Aqua-FM4_Edition1 CER_ES8_Aqua-FM3_Edition2 CER_ES8_Aqua-FM4_Edition2 CER_ES8_Aqua-FM3_Edition1-CV CER_ES8_Aqua-FM4_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1997-12-27; Stop_Date=1999-07-17] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 day; Temporal_Resolution_Range=Daily - < Weekly].

  5. Does point of care prothrombin time measurement reduce the transfusion of fresh frozen plasma in patients undergoing major surgery? The POC-OP randomized-controlled trial

    PubMed Central

    2009-01-01

    Background Bleeding is a frequent complication during surgery. The intraoperative administration of blood products, including packed red blood cells, platelets and fresh frozen plasma (FFP), is often live saving. Complications of blood transfusions contribute considerably to perioperative costs and blood product resources are limited. Consequently, strategies to optimize the decision to transfuse are needed. Bleeding during surgery is a dynamic process and may result in major blood loss and coagulopathy due to dilution and consumption. The indication for transfusion should be based on reliable coagulation studies. While hemoglobin levels and platelet counts are available within 15 minutes, standard coagulation studies require one hour. Therefore, the decision to administer FFP has to be made in the absence of any data. Point of care testing of prothrombin time ensures that one major parameter of coagulation is available in the operation theatre within minutes. It is fast, easy to perform, inexpensive and may enable physicians to rationally determine the need for FFP. Methods/Design The objective of the POC-OP trial is to determine the effectiveness of point of care prothrombin time testing to reduce the administration of FFP. It is a patient and assessor blind, single center randomized controlled parallel group trial in 220 patients aged between 18 and 90 years undergoing major surgery (any type, except cardiac surgery and liver transplantation) with an estimated blood loss during surgery exceeding 20% of the calculated total blood volume or a requirement of FFP according to the judgment of the physicians in charge. Patients are randomized to usual care plus point of care prothrombin time testing or usual care alone without point of care testing. The primary outcome is the relative risk to receive any FFP perioperatively. The inclusion of 110 patients per group will yield more than 80% power to detect a clinically relevant relative risk of 0.60 to receive FFP of

  6. An implementation science protocol of the Women's Health CoOp in healthcare settings in Cape Town, South Africa: A stepped-wedge design.

    PubMed

    Wechsberg, Wendee M; Ndirangu, Jacqueline W; Speizer, Ilene S; Zule, William A; Gumula, Winnifred; Peasant, Courtney; Browne, Felicia A; Dunlap, Laura

    2017-09-18

    HIV persists as a public health emergency in South Africa, especially among women of childbearing age. In response to the HIV epidemic, the Joint United Nations Programme on HIV/AIDS has put forth the 90-90-90 global goals to achieve an AIDS-free generation by 2020. This goal aspires to have 90% of people living with HIV diagnosed; 90% of those who test positive on sustained antiretroviral therapy (ART); and 90% of those on ART be virally suppressed. Ensuring access to ART is an important first step in reducing HIV incidence, especially among vulnerable populations such as women who use substances and bear the burden of HIV in South Africa. Additionally, alcohol and other drug (AOD) use and exposure to gender-based violence are associated with increased risk of HIV infection and reduced adherence to ART. However, no research has estimated ART adherence rates for women who use substances in South Africa since the government approved the provision of ART to all people living with HIV. The Women's Health CoOp (WHC) is an evidence-based, woman-focused, behavioral intervention that addresses the intersecting risks of AODs, sex behaviors, and violence and victimization, with the primary goal of increasing skills and knowledge to reduce substance abuse and HIV risks and to improve ART adherence. The WHC has been packaged for further dissemination. This article describes the study protocol used to assess the feasibility and acceptability of implementing the WHC intervention into standard of care in Cape Town health clinics and substance abuse rehabilitation centers to reduce HIV risk behavior and increase ART adherence among women who use substances and are living with HIV. Because few of the interventions that demonstrate efficacy for HIV prevention and ART adherence in randomized trials are sustainable, studies to adapt and test intervention variations are needed to determine the best strategies for implementing them in real-world, high-risk settings. However

  7. Comparison of Geomagnetically-shielded Solar Energetic Proton Fluxes Observed at Geostationary Orbit by GOES and in Low-earth Orbit by SAMPEX, POES and MetOp

    NASA Astrophysics Data System (ADS)

    Rodriguez, J. V.; Mazur, J. E.; Green, J. C.; Machol, J. L.

    2012-12-01

    On the current (13-15) and upcoming (R+) series of NOAA Geostationary Operational Environmental Satellites (GOES), solar protons are observed from each satellite in the eastward and westward directions. Solar protons that arrive at a given location in the inner magnetosphere have energies greater than their geomagnetic cutoffs, which depend on direction of arrival as well as the strength of geomagnetic disturbances. Protons arriving from the west at geostationary orbit (GEO) have much lower geomagnetic cutoff energies than protons arriving from the east. As a result, GOES westward observations of >4 MeV protons are representative of the interplanetary population near Earth and serve as the basis for NOAA's real-time solar radiation storm alerts. While the GOES westward observations are similar to the Solar, Anomalous and Magnetospheric Particle Explorer (SAMPEX) Proton-Electron Telescope (PET) proton observations in the polar cap (above invariant L = 10), GOES eastward observations more closely approximate the PET observations at invariant L = 4-4.5 in low earth orbit (LEO). Therefore, GOES may potentially provide a real-time, two-point estimate of the radial gradient of solar energetic protons between L = 6.6 and L = 4. However, the PET observations at L = 4-4.5 exhibit a much wider range of variability than the GOES eastward observations. Therefore, the purpose of this study is to determine how representative the GOES two-point gradient estimate is as a function of magnetic local time and geographic longitude. The study encompasses the largest solar proton events (SPE) in Solar Cycle 23 and to date in Solar Cycle 24. From April 1998 through December 2006, GOES 10 provides eastward GEO and SAMPEX PET provides LEO observations of large SPEs. The Solar Cycle 24 GEO observations are provided by GOES 13 and 15. From July 1998 to date, the Space Environment Monitors (SEM-2) on the NOAA Polar Operational Environmental Satellites (POES) and EUMETSAT MetOp-A provide SPE

  8. Evaluating a New Homogeneous Total Ozone Climate Data Record from GOME/ERS-2, SCIAMACHY/Envisat, and GOME-2/MetOp-A

    NASA Technical Reports Server (NTRS)

    Koukouli, M.E.; Lerot, C.; Granville, J.; Goutail, F.; Lambert, J.-C.; Pommereau, J.-P.; Balis, D.; Zyrichidou, I.; Van Roozendael, M.; Coldewey-Egbers, M.; hide

    2015-01-01

    The European Space Agency's Ozone Climate Change Initiative (O3-CCI) project aims at producing and validating a number of high-quality ozone data products generated from different satellite sensors. For total ozone, the O3-CCI approach consists of minimizing sources of bias and systematic uncertainties by applying a common retrieval algorithm to all level 1 data sets, in order to enhance the consistency between the level 2 data sets from individual sensors. Here we present the evaluation of the total ozone products from the European sensors Global Ozone Monitoring Experiment (GOME)/ERS-2, SCIAMACHY/Envisat, and GOME-2/MetOp-A produced with the GOME-type Direct FITting (GODFIT) algorithm v3. Measurements from the three sensors span more than 16 years, from 1996 to 2012. In this work, we present the latest O3-CCI total ozone validation results using as reference ground-based measurements from Brewer and Dobson spectrophotometers archived at the World Ozone and UV Data Centre of the World Meteorological Organization as well as from UV-visible differential optical absorption spectroscopy (DOAS)/Système D'Analyse par Observations Zénithales (SAOZ) instruments from the Network for the Detection of Atmospheric Composition Change. In particular, we investigate possible dependencies in these new GODFIT v3 total ozone data sets with respect to latitude, season, solar zenith angle, and different cloud parameters, using the most adequate type of ground-based instrument. We show that these three O3-CCI total ozone data products behave very similarly and are less sensitive to instrumental degradation, mainly as a result of the new reflectance soft-calibration scheme. The mean bias to the ground-based observations is found to be within the 1 plus or minus 1 percent level for all three sensors while the near-zero decadal stability of the total ozone columns (TOCs) provided by the three European instruments falls well within the 1-3 percent requirement of the European Space

  9. Incidence des infections du site opératoire en Afrique sub-saharienne: revue systématique et méta-analyse

    PubMed Central

    Ngaroua; Ngah, Joseph Eloundou; Bénet, Thomas; Djibrilla, Yaouba

    2016-01-01

    Introduction Les Infections du Sites Opératoire (ISO) sont à l’origine de morbi-mortalité et des dépenses supplémentaires en santé. Les pays en développement en sont les plus touchés. L’objectif était d’estimer l’incidence poolée des ISO en Afrique Sub-saharienne et décrire ses principaux facteurs de risque. Méthodes Une revue systématique et une méta-analyse ont été effectuées à partir des bases de données de l’Organisation Mondiale de la Santé pour la Région Afrique, de PubMed et par recherche standard afin de sélectionner des articles électroniquespubliés entre 2006 et 2015. Seuls les articlestraitants de l’incidence et desfacteurs de risque des ISOdans les pays del’Afrique subsaharienneétaient retenus. Résultats Sur 95 articles trouvés, 11 ont répondu aux critères d’inclusion. Seulement 9 pays sur les 45 y ont contribués avec une grandereprésentation du Nigéria (5 articles sur 11). L’incidence des ISO variaient de 6,8% à 26% avec une prédominance en chirurgie générale. L’incidence poolée des ISO était de 14.8% (IC à 95%: 15,5-16,2%), avec une importante hétérogénéité selon la spécialité et le mode de surveillance. Les facteurs de risque les plus citésétaient la longue durée d’intervention et la classe de contamination d’Altemeir 3 et 4. Les autres facteurs concernaient l’environnement hospitalier, les pratiques de soins inadéquats et les pathologies sous-jacentes. Conclusion L’incidence des ISO est élevée en Afrique subsaharienne, des études dans cette région pourrait améliorer la connaissance, laprévention et la maitrise deces multiples facteurs de risques. PMID:27795768

  10. Variabilité inter et intra-opérateur de l’analyse des paramètres spermatiques: résultat d’un programme de contrôle de qualité

    PubMed Central

    Daoud, Salima; Chakroun-Feki, Nozha; Sellami, Afifa; Ammar-Keskes, Leila; Rebai, Tarek

    2016-01-01

    Introduction L’analyse du sperme est d’une importance majeure dans l’exploration de l'infertilité masculine. Afin de s’assurer de la fiabilité des résultats rendus, l’implantation du management de qualité en spermiologie est devenue une nécessité.Le but de ce travail a été d’évaluer la variabilité intra- et inter-opérateurau cours de l’analyse des paramètres spermatiques au sein de notre laboratoire de spermiologie, à travers la mise en place d’un programme de contrôle de qualité. Méthodes Quatre opérateurs ayant des niveaux d’expérience différents ont participé à l’étude. La variabilité inter-individuelle des résultats des lectures de la mobilité, la concentration et la morphologie spermatique a été évaluée sur plusieurs échantillons de sperme de qualités différentes. Pour chaque paramètre spermatique, la variabilité intra-individuelle a été évaluée en analysant les résultats des lectures de plusieurs aliquotes issus de chacun des échantillons utilisés. Résultats Les coefficients de variation moyens inter-opérateurs ont été de12.8%, 19.8% et 48.9% pour la mobilité, la concentration et la morphologie spermatique, respectivement. Les coefficients de variation moyens intra-opérateurs ont été de6.9%, 12.3%et 42.7% pour la mobilité, la concentration, et la morphologie spermatique, respectivement. Mis à part quelques écarts (erreurs aléatoires), la plupart des mesures réalisées ont été dans les limites d’acceptabilité pour l’ensemble des opérateurs.La variabilité de l’évaluation morphologique des spermatozoïdes a été particulièrement influencée par le niveau d’expérience de l’opérateur. Conclusion Les résultats de cette étude mettent l’accent sur la nécessité d’une formation adéquate du personnel de laboratoire, et de la participation régulière aux contrôles de qualité internes afin de minimiser les divergences et d’améliorer la fiabilité des r

  11. Identification of opsA, a Gene Involved in Solute Stress Mitigation and Survival in Soil, in the Polycyclic Aromatic Hydrocarbon-Degrading Bacterium Novosphingobium sp. Strain LH128

    PubMed Central

    Fida, Tekle Tafese; Breugelmans, Philip; Lavigne, Rob; van der Meer, Jan Roelof; De Mot, René; Vaysse, Pierre-Joseph

    2014-01-01

    The aim of this study was to identify genes involved in solute and matric stress mitigation in the polycyclic aromatic hydrocarbon (PAH)-degrading Novosphingobium sp. strain LH128. The genes were identified using plasposon mutagenesis and by selection of mutants that showed impaired growth in a medium containing 450 mM NaCl as a solute stress or 10% (wt/vol) polyethylene glycol (PEG) 6000 as a matric stress. Eleven and 14 mutants showed growth impairment when exposed to solute and matric stresses, respectively. The disrupted sequences were mapped on a draft genome sequence of strain LH128, and the corresponding gene functions were predicted. None of them were shared between solute and matric stress-impacted mutants. One NaCl-affected mutant (i.e., NA7E1) with a disruption in a gene encoding a putative outer membrane protein (OpsA) was susceptible to lower NaCl concentrations than the other mutants. The growth of NA7E1 was impacted by other ions and nonionic solutes and by sodium dodecyl sulfate (SDS), suggesting that opsA is involved in osmotic stress mitigation and/or outer membrane stability in strain LH128. NA7E1 was also the only mutant that showed reduced growth and less-efficient phenanthrene degradation in soil compared to the wild type. Moreover, the survival of NA7E1 in soil decreased significantly when the moisture content was decreased but was unaffected when soluble solutes from sandy soil were removed by washing. opsA appears to be important for the survival of strain LH128 in soil, especially in the case of reduced moisture content, probably by mitigating the effects of solute stress and retaining membrane stability. PMID:24657861

  12. OpT2mise: a randomized controlled trial to compare insulin pump therapy with multiple daily injections in the treatment of type 2 diabetes-research design and methods.

    PubMed

    Aronson, Ronnie; Cohen, Ohad; Conget, Ignacio; Runzis, Sarah; Castaneda, Javier; de Portu, Simona; Lee, Scott; Reznik, Yves

    2014-07-01

    In insulin-requiring type 2 diabetes patients, current insulin therapy approaches such as basal-alone or basal-bolus multiple daily injections (MDI) have not consistently provided achievement of optimal glycemic control. Previous studies have suggested a potential benefit of continuous subcutaneous insulin infusion (CSII) in these patients. The OpT2mise study is a multicenter, randomized, trial comparing CSII with MDI in a large cohort of subjects with evidence of persistent hyperglycemia despite previous MDI therapy. Subjects were enrolled into a run-in period for optimization of their MDI insulin regimen. Subjects showing persistent hyperglycemia (glycated hemoglobin [HbA1c] ≥8% and ≤12%) were then randomly assigned to CSII or continuing an MDI regimen for a 6-month phase followed by a single crossover of the MDI arm, switching to CSII. The primary end point is the between-group difference in mean change in HbA1c from baseline to 6 months. Secondary end points include change in mean 24-h glucose values, area under the curve and time spent in hypoglycemia and hyperglycemia, measures of glycemic excursions, change in postprandial hyperglycemia, and evaluation of treatment satisfaction. Safety end points include hypoglycemia, hospital admissions, and emergency room visits. When subject enrollment was completed in May 2013, 495 subjects had been enrolled in the study. The study completion for the primary end point is expected in January 2014. OpT2mise will represent the largest studied homogeneous cohort of type 2 diabetes patients with persistent hyperglycemia despite optimized MDI therapy. OpT2mise will help define the role of CSII in insulin intensification and define its safety, rate of hypoglycemia, patient adherence, and patient satisfaction.

  13. Identification of opsA, a gene involved in solute stress mitigation and survival in soil, in the polycyclic aromatic hydrocarbon-degrading bacterium Novosphingobium sp. strain LH128.

    PubMed

    Fida, Tekle Tafese; Breugelmans, Philip; Lavigne, Rob; van der Meer, Jan Roelof; De Mot, René; Vaysse, Pierre-Joseph; Springael, Dirk

    2014-06-01

    The aim of this study was to identify genes involved in solute and matric stress mitigation in the polycyclic aromatic hydrocarbon (PAH)-degrading Novosphingobium sp. strain LH128. The genes were identified using plasposon mutagenesis and by selection of mutants that showed impaired growth in a medium containing 450 mM NaCl as a solute stress or 10% (wt/vol) polyethylene glycol (PEG) 6000 as a matric stress. Eleven and 14 mutants showed growth impairment when exposed to solute and matric stresses, respectively. The disrupted sequences were mapped on a draft genome sequence of strain LH128, and the corresponding gene functions were predicted. None of them were shared between solute and matric stress-impacted mutants. One NaCl-affected mutant (i.e., NA7E1) with a disruption in a gene encoding a putative outer membrane protein (OpsA) was susceptible to lower NaCl concentrations than the other mutants. The growth of NA7E1 was impacted by other ions and nonionic solutes and by sodium dodecyl sulfate (SDS), suggesting that opsA is involved in osmotic stress mitigation and/or outer membrane stability in strain LH128. NA7E1 was also the only mutant that showed reduced growth and less-efficient phenanthrene degradation in soil compared to the wild type. Moreover, the survival of NA7E1 in soil decreased significantly when the moisture content was decreased but was unaffected when soluble solutes from sandy soil were removed by washing. opsA appears to be important for the survival of strain LH128 in soil, especially in the case of reduced moisture content, probably by mitigating the effects of solute stress and retaining membrane stability.

  14. Etats hémodynamiques et respiratoires des opérées de fistules obstétricales sous rachianesthésie au CHRR Manakara, Madagascar

    PubMed Central

    Martinetti, Andrianimaro Florelia; Franklin, Rabenjarison; Lalao, Randriamboavonjy Rado; Judicael, Harioly Nirina Marie Osé; Yvonne, Rasolonjatovo Tsiorintsoa; Andriambelo, Rajaonera Tovohery; Nicole, Rakotoarison Ratsaraharimanana Catherine; Enintsoa, Raveloson Nasolotsiry; Edwige, Ravaomanana

    2016-01-01

    L'objectif était d'évaluer les états hémodynamiques et respiratoires des opérées de fistules obstétricales et rapporter nos expériences sur la prise en charge de ces malades. Il s'agit d'une étude transversale descriptive effectuée au Bloc opératoire et Réanimation du CHRR Manakara allant du 20 au 30 aout 2013. Etaient incluses les patientes opérées de fistules obstétricales sous rachianesthésie. Nous avons exclu les patientes classées ASA >2 et celles ayant des tares cardio-vasculaires ou respiratoires. Après consultations préanesthésiques, et bilans préopératoires, nous avons administré chez les patientes 12,5mg de bupivacaïne adrénalinée 0,5% isobare en intrathécal. Elles étaient mises en position de Trendelenburg 5 minutes après l'injection du produit anesthésique et durant toute l'intervention. Le niveau sensitif, la pression artérielle, la fréquence cardiaque, la fréquence respiratoire et la saturation pulsée en oxygène (SpO2) étaient enregistrés pendant l'intervention. Nous avons retenues 57 malades. Le bloc sensitivomoteur était excellent pour toutes les malades. Un niveau métamérique supérieur à T6 était atteint chez 56,36% des malades. A part quelques épisodes d'hypertension artérielle et tachycardie, nous n'avons trouvé aucune difficulté respiratoire ni cardiovasculaire en rapport avec la position. Seuls, le niveau sensitif et la fréquence respiratoire présentaient une corrélation (p=0,01). Cette étude suggère que la position de Trendelenburg est réalisable au cours de la rachianesthésie en utilisant un produit anesthésique approprié, en faisant attention, notamment aux changements de position et en tenant compte de l'examen préanesthésique. PMID:28292102

  15. Effectiveness of functional hand splinting and the cognitive orientation to occupational performance (CO-OP) approach in children with cerebral palsy and brain injury: two randomised controlled trial protocols

    PubMed Central

    2014-01-01

    Background Cerebral palsy (CP) and brain injury (BI) are common conditions that have devastating effects on a child’s ability to use their hands. Hand splinting and task-specific training are two interventions that are often used to address deficits in upper limb skills, both in isolation or concurrently. The aim of this paper is to describe the method to be used to conduct two randomised controlled trials (RCT) investigating (a) the immediate effect of functional hand splints, and (b) the effect of functional hand splints used concurrently with task-specific training compared to functional hand splints alone, and to task-specific training alone in children with CP and BI. The Cognitive Orientation to Occupational Performance (CO-OP) approach will be the task-specific training approach used. Methods/Design Two concurrent trials; a two group, parallel design, RCT with a sample size of 30 participants (15 per group); and a three group, parallel design, assessor blinded, RCT with a sample size of 45 participants (15 per group). Inclusion criteria: age 4-15 years; diagnosis of CP or BI; Manual Abilities Classification System (MACS) level I – IV; hand function goals; impaired hand function; the cognitive, language and behavioural ability to participate in CO-OP. Participants will be randomly allocated to one of 3 groups; (1) functional hand splint only (n=15); (2) functional hand splint combined with task-specific training (n=15); (3) task-specific training only (n=15). Allocation concealment will be achieved using sequentially numbered, sealed opaque envelopes opened by an off-site officer after baseline measures. Treatment will be provided for a period of 2 weeks, with outcome measures taken at baseline, 1 hour after randomisation, 2 weeks and 10 weeks. The functional hand splint will be a wrist cock-up splint (+/- thumb support or supination strap). Task-specific training will involve 10 sessions of CO-OP provided in a group of 2-4 children. Primary outcome

  16. Insulin pump treatment compared with multiple daily injections for treatment of type 2 diabetes (OpT2mise): a randomised open-label controlled trial.

    PubMed

    Reznik, Yves; Cohen, Ohad; Aronson, Ronnie; Conget, Ignacio; Runzis, Sarah; Castaneda, Javier; Lee, Scott W

    2014-10-04

    Many patients with advanced type 2 diabetes do not meet their glycated haemoglobin targets and randomised controlled studies comparing the efficacy of pump treatment and multiple daily injections for lowering glucose in insulin-treated patients have yielded inconclusive results. We aimed to resolve this uncertainty with a randomised controlled trial (OpT2mise). We did this multicentre, controlled trial at 36 hospitals, tertiary care centres, and referal centres in Canada, Europe, Israel, South Africa, and the USA. Patients with type 2 diabetes who had poor glycaemic control despite multiple daily injections with insulin analogues were enrolled into a 2-month dose-optimisation run-in period. After the run-in period, patients with glycated haemoglobin of 8·0-12·0% (64-108 mmol/mol) were randomly assigned (1:1) by a computer-generated randomisation sequence (block size 2 with probability 0·75 and size 4 with probability 0·25) to pump treatment or to continue with multiple daily injections. Neither patients nor investigators were masked to treatment allocation. The primary endpoint was change in mean glycated haemoglobin between baseline and end of the randomised phase for the intention-to-treat population. This study is registered with ClinicalTrials.gov, number NCT01182493. 495 of 590 screened patients entered the run-in phase and 331 were randomised (168 to pump treatment, 163 to multiple daily injections). Mean glycated haemoglobin at baseline was 9% (75 mmol/mol) in both groups. At 6 months, mean glycated haemoglobin had decreased by 1·1% (SD 1·2; 12 mmol/mol, SD 13) in the pump treatment group and 0·4% (SD 1·1; 4 mmol/mol, SD 12) in the multiple daily injection group, resulting in a between-group treatment difference of -0·7% (95% CI -0·9 to -0·4; -8 mmol/mol, 95% CI -10 to -4, p<0·0001). At the end of the study, the mean total daily insulin dose was 97 units (SD 56) with pump treatment versus 122 units (SD 68) for multiple daily injections (p<0·0001

  17. Factors associated with improved glycemic control following continuous subcutaneous insulin infusion therapy in patients with type 2 diabetes uncontrolled with bolus-basal insulin regimens: an analysis from the OpT2mise randomized trial.

    PubMed

    Metzger, Muriel; Castañeda, Javier; Reznik, Yves; Giorgino, Francesco; Conget, Ignacio; Aronson, Ronnie; de Portu, Simona; Runzis, Sarah; Lee, Scott W; Cohen, Ohad

    2017-04-04

    This analysis investigated factors associated with the decrease in HbA1c in patients receiving continuous subcutaneous insulin infusion (CSII) in the OpT2mise randomized trial. In this study, patients with type 2 diabetes and HbA1C >8% following multiple daily injections (MDI) optimization were randomized to receive CSII (n = 168) or MDI (n = 163) for 6 months. Patient-related and treatment-related factors associated with decreased HbA1c in the CSII arm were identified by univariate and multivariate analyses. CSII produced a significantly greater reduction in HbA1c than MDI, and the treatment difference increased with baseline HbA1c . In the CSII arm, the only factors significantly associated with decreased HbA1C were higher baseline HbA1C (P<0.001), geographical region (P<0.001), higher educational level (P=0.012), higher total cholesterol level (P=0.002), lower variability of baseline glucose values on continuous glucose monitoring (P<0.001), and the decrease in average fasting self-monitored blood glucose at 6 months (P<0.001). These findings suggest that CSII offers an option to improve glycemic control in a broad range of type 2 diabetes patients in whom control cannot be achieved with MDI. OpT2mise ClinicalTrials.gov number: NCT01182493 (https://clinicaltrials.gov/).

  18. Next generation OP-bioscavengers: a circulatory long-lived 4-PEG hypolysine mutant of F338A-HuAChE with optimal pharmacokinetics and pseudo-catalytic characteristics.

    PubMed

    Kronman, Chanoch; Cohen, Ofer; Mazor, Ohad; Ordentlich, Arie; Raveh, Lily; Velan, Baruch; Shafferman, Avigdor

    2010-09-06

    We have shown previously that conjugation of polyethylene glycol (PEG) chains to recombinant human acetylcholinesterase (rHuAChE) results in the extension of its residence time in the circulation of mice and monkeys [1,2]. By profiling the pharmacokinetic behavior of an array of well-defined hypolysine human mutant AChE molecules following PEGylation, we now determine that the duration of these enzyme forms in the circulation of rhesus macaques correlates with their number of appended PEG moieties, and is influenced by the actual location of the PEG chains at the molecule surface, as well. These findings, which concur with those we have previously established in mice, indicate that a common set of rules dictates the circulatory fate of PEGylated HuAChEs in rodents and non-human primates. In addition to its effect on circulatory residence, PEGylation reduces the ability of the rHuAChE bioscavenger to elicit an immune response in the heterologous mouse animal system. Thus, an inverse relationship between anti-AChE antibody production and PEG loading was observed following repeated administration of the different PEGylated hypolysine human AChEs to mice. We note however, that in rhesus macaques, the essentially homologous (human) AChE does not induce specific anti-AChE antibodies after repeated administration of high doses of the enzyme in its PEGylated form, and even in its non-PEGylated form. Taken together, these findings indicate that PEG acts by veiling enzyme-related epitopes, which would otherwise interact with host circulatory elimination pathways and immune system. The barring of such interactions by obstructive PEGs, confers the enzyme molecule with both extended circulatory residence and mitigated immunogenic properties. Further modulation by incorporation of the F338A mutation into the PEGylated hypolysine rHuAChE enzyme mold, resulted in the generation of an OP-bioscavenger that displayed reduced aging rates and could effectively protect mice against

  19. Les myélopathies cervicarthrosiques: résultat clinique et radiologique de la chirurgie sur une série de 135 patients opérés au service de neurochirurgie CHU Avicenne

    PubMed Central

    Djoubairou, Ben Ousmanou; Nabil, Moussé; Karekezi, Claire; Diawara, Seylan; El Fatemi, Nizar; Gana, Rachid; El Abbadi, Najia; Maaqili, Moulay Rachid

    2014-01-01

    La myélopathie cervicarthrosique est un syndrome clinique en relation avec la diminution des dimensions du canal rachidien, la cervicarthrose est l’étiologie principale après 50 ans. L'objectif du traitement est de rétablir les dimensions du canal rachidien cervical. Le choix de la technique chirurgicale sera guidé par l'analyse des signes cliniques, imageries, pré opératoire en fonction de laquelle sera pratiquée soit la voie antérieure, postérieure, ou exceptionnellement la voie combinée. Notre étude a pour but dans un premier temps d’évaluer à long terme les résultats cliniques et radiologiques de la chirurgie ensuite répondre à cette préoccupation: La lordose cervicale pré opératoire et postopératoire sont t-elles des facteurs de bon pronostic? Nous rapportons une étude rétrospective entre 2000 et 2013 portant sur 135 patients opérés dans notre formation et remplissant les critères inclusions. La collecte des données s'est faite en s'aidant du dossier médical des patients (échelle d'Association des orthopédistes Japonais), Imagerie (Radio, TDM, IRM), mesure de l'angle de courbure rachidienne en pré et postopératoire, ceci dans le but d’évaluer à long terme les résultats clinique et radiologique de la chirurgie. Ont été inclus dans notre étude 135 patients, 82 Hommes (60%), 53 femmes (40%) avec un âge moyen de 52 ans, ayant consulté pour des motifs divers (Névralgies cervicobrachiales, lourdeur des membres, troubles génito-sphinctériens). Soixante cinq patients (48%) ont bénéficié d'un abord antérieur (dissectomie, cloward, somatotomie médiane), 64 patients (47%) ont été opérés par voie postérieure (laminectomie de 1 à 3 niveaux) et 6 patients (5%) ont bénéficié d'un abord combiné dans un délai moyen de 3 mois devant la persistance des symptômes. Le niveau cervical le plus touché était C5C6 suivie de C4C5. L’évolution globale de nos patients était favorable dans 58% des cas, stationnaire

  20. Identification of plant cells in black pigments of prehistoric Spanish Levantine rock art by means of a multi-analytical approach. A new method for social identity materialization using chaîne opératoire.

    PubMed

    López-Montalvo, Esther; Roldán, Clodoaldo; Badal, Ernestina; Murcia-Mascarós, Sonia; Villaverde, Valentín

    2017-01-01

    We present a new multi-analytical approach to the characterization of black pigments in Spanish Levantine rock art. This new protocol seeks to identify the raw materials that were used, as well as reconstruct the different technical gestures and decision-making processes involved in the obtaining of these black pigments. For the first of these goals, the pictorial matter of the black figurative motifs documented at the Les Dogues rock art shelter (Ares del Maestre, Castellón, Spain) was characterized through the combination of physicochemical and archeobotanical analyses. During the first stage of our research protocol, in situ and non-destructive analyses were carried out by means of portable Energy Dispersive X-Ray Fluorescence spectrometry (EDXRF); during the second stage, samples were analyzed by Optical Microscopy (OM), Raman spectroscopy, and Scanning Electron Microscopy coupled with Energy Dispersive X-ray spectroscopy (SEM-EDX). Two major conclusions have been drawn from these analyses: first, charred plant matter has been identified as a main component of these prehistoric black pigments; and second, angiosperm and conifer charcoal was a primary raw material for pigment production, identified by means of the archaeobotanical study of plant cells. For the second goal, black charcoal pigments were replicated in the laboratory by using different raw materials and binders and by reproducing two main chaînes opératoires. The comparative study of the structure and preservation of plant tissues of both prehistoric and experimental pigments by means of SEM-EDX underlines both a complex preparation process and the use of likely pigment recipes, mixing raw material with fatty or oily binders. Finally, the formal and stylistic analysis of the motifs portrayed at Les Dogues allowed us to explore the relationship between identified stylistic phases and black charcoal pigment use, raising new archaeological questions concerning the acquisition of know-how and the

  1. Identification of plant cells in black pigments of prehistoric Spanish Levantine rock art by means of a multi-analytical approach. A new method for social identity materialization using chaîne opératoire

    PubMed Central

    Roldán, Clodoaldo; Badal, Ernestina; Murcia-Mascarós, Sonia; Villaverde, Valentín

    2017-01-01

    We present a new multi-analytical approach to the characterization of black pigments in Spanish Levantine rock art. This new protocol seeks to identify the raw materials that were used, as well as reconstruct the different technical gestures and decision-making processes involved in the obtaining of these black pigments. For the first of these goals, the pictorial matter of the black figurative motifs documented at the Les Dogues rock art shelter (Ares del Maestre, Castellón, Spain) was characterized through the combination of physicochemical and archeobotanical analyses. During the first stage of our research protocol, in situ and non-destructive analyses were carried out by means of portable Energy Dispersive X-Ray Fluorescence spectrometry (EDXRF); during the second stage, samples were analyzed by Optical Microscopy (OM), Raman spectroscopy, and Scanning Electron Microscopy coupled with Energy Dispersive X-ray spectroscopy (SEM-EDX). Two major conclusions have been drawn from these analyses: first, charred plant matter has been identified as a main component of these prehistoric black pigments; and second, angiosperm and conifer charcoal was a primary raw material for pigment production, identified by means of the archaeobotanical study of plant cells. For the second goal, black charcoal pigments were replicated in the laboratory by using different raw materials and binders and by reproducing two main chaînes opératoires. The comparative study of the structure and preservation of plant tissues of both prehistoric and experimental pigments by means of SEM-EDX underlines both a complex preparation process and the use of likely pigment recipes, mixing raw material with fatty or oily binders. Finally, the formal and stylistic analysis of the motifs portrayed at Les Dogues allowed us to explore the relationship between identified stylistic phases and black charcoal pigment use, raising new archaeological questions concerning the acquisition of know-how and the

  2. eddy4R 0.2.0: a DevOps model for community-extensible processing and analysis of eddy-covariance data based on R, Git, Docker, and HDF5

    NASA Astrophysics Data System (ADS)

    Metzger, Stefan; Durden, David; Sturtevant, Cove; Luo, Hongyan; Pingintha-Durden, Natchaya; Sachs, Torsten; Serafimovich, Andrei; Hartmann, Jörg; Li, Jiahong; Xu, Ke; Desai, Ankur R.

    2017-08-01

    Large differences in instrumentation, site setup, data format, and operating system stymie the adoption of a universal computational environment for processing and analyzing eddy-covariance (EC) data. This results in limited software applicability and extensibility in addition to often substantial inconsistencies in flux estimates. Addressing these concerns, this paper presents the systematic development of portable, reproducible, and extensible EC software achieved by adopting a development and systems operation (DevOps) approach. This software development model is used for the creation of the eddy4R family of EC code packages in the open-source R language for statistical computing. These packages are community developed, iterated via the Git distributed version control system, and wrapped into a portable and reproducible Docker filesystem that is independent of the underlying host operating system. The HDF5 hierarchical data format then provides a streamlined mechanism for highly compressed and fully self-documented data ingest and output. The usefulness of the DevOps approach was evaluated for three test applications. First, the resultant EC processing software was used to analyze standard flux tower data from the first EC instruments installed at a National Ecological Observatory (NEON) field site. Second, through an aircraft test application, we demonstrate the modular extensibility of eddy4R to analyze EC data from other platforms. Third, an intercomparison with commercial-grade software showed excellent agreement (R2 = 1.0 for CO2 flux). In conjunction with this study, a Docker image containing the first two eddy4R packages and an executable example workflow, as well as first NEON EC data products are released publicly. We conclude by describing the work remaining to arrive at the automated generation of science-grade EC fluxes and benefits to the science community at large. This software development model is applicable beyond EC and more generally builds

  3. Effects of CaO/P2O5 ratio on the structure and elastic properties of SiO2-CaO-Na2O-P2O5 bioglasses.

    PubMed

    Lin, Chung-Cherng; Chen, Shih-Fan; Leung, Kak Si; Shen, Pouyan

    2012-02-01

    The evolution of elastic properties and structure upon the change of CaO/P(2)O(5) ratio in SiO(2)-CaO-Na(2)O-P(2)O(5) glasses (45S5-derived and 55S4-derived) at ambient conditions has been studied by using both Brillouin and Raman spectroscopy coupled with X-ray diffraction. Under the same SiO(2)/Na(2)O ratio, it is found that a decrease in CaO/P(2)O(5) molar ratio has caused a more-polymerized silicate network via a net consumption of Q(0), Q(1), and Q(2) species yet enriching in Q(3) and Q(4) species. Brillouin experiments revealed that all the bulk, shear and Young's moduli of the glasses studied increases with the increase of CaO/P(2)O(5) molar ratio. The unexpected variation trend in shear modulus can be correlated to the contribution from cohesion, the less-polymerized phosphate Q species, and density. Compared to the 45S5-derived, the more-polymerized 55S4-deived glass has a lower bulk but slightly higher shear modulus at the given CaO/P(2)O(5) ratio.

  4. Structural and magnetic properties of SiO2-CaO-Na2O-P2O5 containing BaO-Fe2O3 glass-ceramics

    NASA Astrophysics Data System (ADS)

    Leenakul, W.; Kantha, P.; Pisitpipathsin, N.; Rujijanagul, G.; Eitssayeam, S.; Pengpat, K.

    2013-01-01

    The incorporation method was employed to produce bioactive glass-ceramics from the BaFe12O19-SiO2-CaO-Na2O-P2O5 glass system. The ferrimagnetic BaFe12O19 was first prepared using a simple mixed oxide method, where the oxide precursors of 45S5 bioglass were initially mixed and then melted to form glass. The devitrification of Na3Ca6(PO4)5 and Fe3O4 was observed in all of the quenched glass samples. The glass samples were then subjected to a heat treatment schedule for further crystallization. It was found that the small traces of BaFe12O19 phases started to crystallize in high BF content samples of 20 and 40 wt%. These samples also exhibited good magnetic properties comparable to that of other magnetic glass-ceramics. The bioactivity of the BF glass-ceramics improved with increasing BF content as was evident by the formation of bone-like apatite layers on the surface of all of the glass-ceramics after soaking in SBF for 14 days. The results support the use of these bioactive glass-ceramics for hyperthermia treatment within the human body.

  5. Un anévrysme sacciforme de l'aorte abdominale révélant une maladie de Behçet: quand faut-il opérer?

    PubMed Central

    Ajili, Faida; Tounsi, Haifa; Aouini, Fatma; Bousetta, Najeh; Ben Abdelhafidh, Nadia; Louzir, Bassem; Laabidi, Janet; Othmani, Salah

    2014-01-01

    L'atteinte vasculaire est fréquente au cours de la maladie de Behçet. Elle est essentiellement représentée par les thromboses veineuses alors que l'atteinte artérielle est plus rare. Elle peut être isolée ou multifocale et peut toucher tous les territoires avec prédilection pour l'aorte abdominale, les artères pulmonaires et les artères des membres inférieurs. L'atteinte anévrysmale de l'aorte abdominale est trompeuse se manifestant par une symptomatologie atypique responsable d'un retard diagnostique favorisant la rupture. Dans notre cas, des douleurs abdominales paroxystiques ont incité le patient à consulter rapidement. L'enquête étiologique a conclue à un angio Behcet. Rarement, l'anévrysme de l'aorte abdominale est révélé par une complication telle que la rupture dans le rétro péritoine ou le tube digestif. Les indications chirurgicales des anévrysmes de l'aorte sont discutées ici. Un traitement immunosuppresseur au long cours s'impose en post opératoire pour limiter le risque de récidive. PMID:25852795

  6. State of the (t)art. Analytical approaches in the investigation of components and production traits of archaeological bread-like objects, applied to two finds from the Neolithic lakeshore settlement Parkhaus Opéra (Zürich, Switzerland)

    PubMed Central

    Marinova, Elena; Stika, Hans-Peter; Valamoti, Soultana Maria

    2017-01-01

    The site of Parkhaus Opéra is located on the north-eastern shore of Lake Zürich (Switzerland) and was documented during a rescue excavation in 2010 and 2011 by the Office for Urbanism, City of Zürich. Two charred bread-like objects were found in late Neolithic Layer 13 of the pile-dwelling, and are investigated using a novel set of analyses for cereal-based foodstuffs. Tissue remains of barley and wheat were identified, as well as a schizocarp of celery (cf. Apium graveolens), providing the first evidence for the use of bread condiments in the Neolithic. Cereal particle sizes were recorded and used to draw conclusions regarding milling and sieving of the raw material. Gas bubbles in the charred objects were measured in order to evaluate possible leavening of the dough. The outcomes of this research significantly advance the understanding of the production traits of cereal-based food during the Neolithic. The analytical techniques proposed by this study open up new possibilities for systematic and consistent investigations of cereal-based archaeological foodstuffs. PMID:28771539

  7. State of the (t)art. Analytical approaches in the investigation of components and production traits of archaeological bread-like objects, applied to two finds from the Neolithic lakeshore settlement Parkhaus Opéra (Zürich, Switzerland).

    PubMed

    Heiss, Andreas G; Antolín, Ferran; Bleicher, Niels; Harb, Christian; Jacomet, Stefanie; Kühn, Marlu; Marinova, Elena; Stika, Hans-Peter; Valamoti, Soultana Maria

    2017-01-01

    The site of Parkhaus Opéra is located on the north-eastern shore of Lake Zürich (Switzerland) and was documented during a rescue excavation in 2010 and 2011 by the Office for Urbanism, City of Zürich. Two charred bread-like objects were found in late Neolithic Layer 13 of the pile-dwelling, and are investigated using a novel set of analyses for cereal-based foodstuffs. Tissue remains of barley and wheat were identified, as well as a schizocarp of celery (cf. Apium graveolens), providing the first evidence for the use of bread condiments in the Neolithic. Cereal particle sizes were recorded and used to draw conclusions regarding milling and sieving of the raw material. Gas bubbles in the charred objects were measured in order to evaluate possible leavening of the dough. The outcomes of this research significantly advance the understanding of the production traits of cereal-based food during the Neolithic. The analytical techniques proposed by this study open up new possibilities for systematic and consistent investigations of cereal-based archaeological foodstuffs.

  8. Synthesis and structure of and DFT-studies on 1,3,5-[P(O)( i-PrO) 2] 3C 6H 3 and its CHCl 3 adduct: analysis of the Cl 3C-H⋯OP hydrogen bond

    NASA Astrophysics Data System (ADS)

    Henn, Markus; Jurkschat, Klaus; Mansfeld, Dirk; Mehring, Michael; Schürmann, Markus

    2004-07-01

    The novel triphosphonic ester 1,3,5-[P(O)( i-PrO) 2] 3C 6H 3 ( 1) was synthesized and fully characterized including single crystal X-ray diffraction analysis. Crystallization in the presence of CHCl 3 gave the corresponding solvate, 1·CHCl 3, which shows moderate C-H⋯OP hydrogen bonding. The hydrogen bond strength in 1·CHCl 3 and the model compound [P(O)( i-PrO) 2]C 6H 5·CHCl 3 ( 2·CHCl 3) were analyzed using RHF, DFT and MP2 methods. The calculated C-H⋯OP hydrogen bond strength is in the range 5-6 kcal mol -1, which is comparable with hydrogen bond strength in the water dimer but higher than in comparable C-H⋯OC aggregates.

  9. Chthonomonas calidirosea gen. nov., sp. nov., an aerobic, pigmented, thermophilic micro-organism of a novel bacterial class, Chthonomonadetes classis nov., of the newly described phylum Armatimonadetes originally designated candidate division OP10.

    PubMed

    Lee, Kevin C-Y; Dunfield, Peter F; Morgan, Xochitl C; Crowe, Michelle A; Houghton, Karen M; Vyssotski, Mikhail; Ryan, Jason L J; Lagutin, Kirill; McDonald, Ian R; Stott, Matthew B

    2011-10-01

    An aerobic, saccharolytic, obligately thermophilic, motile, non-spore-forming bacterium, strain T49(T), was isolated from geothermally heated soil at Hell's Gate, Tikitere, New Zealand. On the basis of 16S rRNA gene sequence similarity, T49(T) is the first representative of a new class in the newly described phylum Armatimonadetes, formerly known as candidate division OP10. Cells of strain T49(T) stained Gram-negative and were catalase-positive and oxidase-negative. Cells possessed a highly corrugated outer membrane. The major fatty acids were 16 : 0, i17 : 0 and ai17 : 0. The G+C content of the genomic DNA was 54.6 mol%. Strain T49(T) grew at 50-73 °C with an optimum temperature of 68 °C, and at pH 4.7-5.8 with an optimum growth pH of 5.3. A growth rate of 0.012 h(-1) was observed under optimal temperature and pH conditions. The primary respiratory quinone was MK-8. Optimal growth was achieved in the absence of NaCl, although growth was observed at NaCl concentrations as high as 2 % (w/v). Strain T49(T) was able to utilize mono- and disaccharides such as cellobiose, lactose, mannose and glucose, as well as branched or amorphous polysaccharides such as starch, CM-cellulose, xylan and glycogen, but not highly linear polysaccharides such as crystalline cellulose or cotton. On the basis of its phylogenetic position and phenotypic characteristics, we propose that strain T49(T) represents a novel bacterial genus and species within the new class Chthonomonadetes classis nov. of the phylum Armatimonadetes. The type strain of Chthonomonas calidirosea gen. nov., sp. nov. is T49(T) ( = DSM 23976(T) = ICMP 18418(T)).

  10. How much do soldiers know about the morphine they carry on operations? A questionnaire study of knowledge and understanding of the morphine auto-injector on Op HERRICK 17.

    PubMed

    Nelson, Sarah C; Wedgwood, J T A

    2015-03-01

    Morphine auto-injectors are issued to all British soldiers on operations in Afghanistan who deploy forward of Camp Bastion, the main British base. Previous studies have reviewed the effectiveness of various pre-hospital analgesics, but there is no record of the knowledge and confidence of the relatively medically untrained soldiers who carry and use intramuscular morphine on the battlefield. The aim of this study was to assess soldiers' knowledge and confidence of the morphine auto-injector with a view to guiding further training. Structured questionnaire distributed to soldiers in two patrol bases in Helmand Province during Op HERRICK 17. 232 questionnaires were completed by a range of ranks and trades. 100% had received mandatory training on the auto-injector and over 70% had received more advanced training. Confidence in using the auto-injector was high, with 47% rating their confidence level as 10/10. Overall, factual knowledge was good with the mean score for the questionnaire being 7.9/10; 95% of respondents knew how to document the use of morphine and 79% knew when a second dose could safely be administered. Some misunderstanding of contraindications was revealed: 9% of answers were incorrect, and 47% wrongly answered that administering morphine to a patient changes the triage category. The majority of soldiers received far more than the minimum required training on the use of the morphine auto-injector. Confidence in using the device is high and generally knowledge is good. The authors suggest that deployed medical personnel in forward locations maintain regular training to soldiers on the morphine auto-injector in order to ensure that casualties receive analgesia appropriately and promptly. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  11. Robonaut 2 during TeleOps

    NASA Image and Video Library

    2013-04-25

    ISS035-E-030779 (25 April 2013) --- R 2, the dexterous humanoid robot that was carried up to the station by one of NASA's final shuttle flights in 2011, awaits a direction from NASA astronaut Tom Marshburn (seen in the robot's visor), Expedition 35 Flight Engineer, who was performing the second of a two-day session of Taskboard and Tele-operations with R 2 onboard the International Space Station. The goals for these activities were orientation and depth familiarization, individual hand grasp and hand-to-hand object transfer; and all were completed nominally. The Robonaut Tele-operation System is used to demonstrate the ability to effectively control Robonaut from the station. The research objective is to evaluate this control method in terms of its ability to perform tasks as well as measure the time necessary to complete the defined tasks. This capability will need to be developed to support future operations of Robonaut in the space environment as well as certain intravehicular activity situations.

  12. Marshburn concludes Robonaut 2 TeleOps

    NASA Image and Video Library

    2013-04-25

    ISS035-E-030804 (25 April 2013) --- NASA astronaut Tom Marshburn (pictured in background), Expedition 35 Flight Engineer, performs the second of a two-day session of Taskboard and Tele-operations with R 2 onboard the International Space Station. R 2 is the dexterous humanoid robot that was carried up to the station by one of NASA's final shuttle flights in 2011. The goals for these activities were orientation and depth familiarization, individual hand grasp and hand-to-hand object transfer; and all were completed nominally. The Robonaut Tele-operation System is used to demonstrate the ability to effectively control Robonaut from the station. The research objective is to evaluate this control method in terms of its ability to perform tasks as well as measure the time necessary to complete the defined tasks. This capability will need to be developed to support future operations of Robonaut in the space environment as well as certain intravehicular activity situations.

  13. Marshburn conducts Robonaut 2 TeleOps

    NASA Image and Video Library

    2013-04-25

    ISS035-E-030791 (25 April 2013) --- NASA astronaut Tom Marshburn (pictured in background), Expedition 35 Flight Engineer, performs the second of a two-day session of Taskboard and Tele-operations with R 2 onboard the International Space Station. R 2 is the dexterous humanoid robot that was carried up to the station by one of NASA's final shuttle flights in 2011. The goals for these activities were orientation and depth familiarization, individual hand grasp and hand-to-hand object transfer; and all were completed nominally. The Robonaut Tele-operation System is used to demonstrate the ability to effectively control Robonaut from the station. The research objective is to evaluate this control method in terms of its ability to perform tasks as well as measure the time necessary to complete the defined tasks. This capability will need to be developed to support future operations of Robonaut in the space environment as well as certain intravehicular activity situations.

  14. Marshburn concludes Robonaut 2 TeleOps

    NASA Image and Video Library

    2013-04-25

    ISS035-E-030794 (25 April 2013) --- NASA astronaut Tom Marshburn (pictured in background), Expedition 35 Flight Engineer, performs the second of a two-day session of Taskboard and Tele-operations with R 2 onboard the International Space Station. R 2 is the dexterous humanoid robot that was carried up to the station by one of NASA's final shuttle flights in 2011. The goals for these activities were orientation and depth familiarization, individual hand grasp and hand-to-hand object transfer; and all were completed nominally. The Robonaut Tele-operation System is used to demonstrate the ability to effectively control Robonaut from the station. The research objective is to evaluate this control method in terms of its ability to perform tasks as well as measure the time necessary to complete the defined tasks. This capability will need to be developed to support future operations of Robonaut in the space environment as well as certain intravehicular activity situations.

  15. Expedition 17 Microgravity Sciences Glovebox (MSG) OPS

    NASA Image and Video Library

    2008-08-23

    ISS017-E-014001 (23 Aug. 2008) --- Astronaut Greg Chamitoff, Expedition 17 flight engineer, works with the Microgravity Sciences Glovebox and the Commercial Generic Bioprocessing Apparatus in the Columbus laboratory on the International Space Station.

  16. Creative Analytics of Mission Ops Event Messages

    NASA Technical Reports Server (NTRS)

    Smith, Dan

    2017-01-01

    Historically, tremendous effort has been put into processing and displaying mission health and safety telemetry data; and relatively little attention has been paid to extracting information from missions time-tagged event log messages. Todays missions may log tens of thousands of messages per day and the numbers are expected to dramatically increase as satellite fleets and constellations are launched, as security monitoring continues to evolve, and as the overall complexity of ground system operations increases. The logs may contain information about orbital events, scheduled and actual observations, device status and anomalies, when operators were logged on, when commands were resent, when there were data drop outs or system failures, and much much more. When dealing with distributed space missions or operational fleets, it becomes even more important to systematically analyze this data. Several advanced information systems technologies make it appropriate to now develop analytic capabilities which can increase mission situational awareness, reduce mission risk, enable better event-driven automation and cross-mission collaborations, and lead to improved operations strategies: Industry Standard for Log Messages. The Object Management Group (OMG) Space Domain Task Force (SDTF) standards organization is in the process of creating a formal standard for industry for event log messages. The format is based on work at NASA GSFC. Open System Architectures. The DoD, NASA, and others are moving towards common open system architectures for mission ground data systems based on work at NASA GSFC with the full support of the commercial product industry and major integration contractors. Text Analytics. A specific area of data analytics which applies statistical, linguistic, and structural techniques to extract and classify information from textual sources. This presentation describes work now underway at NASA to increase situational awareness through the collection of non-telemetry mission operations information into a common log format and then providing display and analytics tools to provide in-depth assessment of the log contents. The work includes: Common interface formats for acquiring time-tagged text messages Conversion of common files for schedules, orbital events, and stored commands to the common log format Innovative displays to depict thousands of messages on a single display Structured English text queries against the log message data store, extensible to a more mature natural language query capability Goal of speech-to-text and text-to-speech additions to create a personal mission operations assistant to aid on-console operations. A wide variety of planned uses identified by the mission operations teams will be discussed.

  17. Co-op Student Work Report

    NASA Technical Reports Server (NTRS)

    Powell, Jessica M.

    2012-01-01

    Projects: (1) Boeing Launch Abort Analysis My first project for the summer was analyzing the Boeing CCDev Vehicle's abort aerodynamics using an inviscid solver (CART3D). The goal of the project was to develop the grid and CFD inputs necessary to use CART3D as a quick tool for investigating loading trends at various points along abort trajectories. As a supplementary task, I analyzed a few cases and compared them to the aerodatabase from the last generation geometry. (2) My second project for the summer dealt with investigating how heating changes as the height of a protuberance on top of a flat plate changes. The goal of this investigation is to better understand how to properly model heating on and around a protuberance. This is one of the biggest challenges when designing a re ]entry vehicle because very small changes in the shape and conditions leading up to a protuberance, not to mention the protuberance geometry, will greatly impact the local heating.

  18. Social enterprise. The co-op conundrum.

    PubMed

    Nolan, Alexis

    2006-04-13

    Social enterprise has opponents at both ends of the political spectrum, viewing it as either having an unfair advantage or the first stage of privatising the NHS. Supporters say there is less bureaucracy and it will focus commissioners on getting better services. In future providers will need to improve their business and financial skills.

  19. CALCIUM. Photography of the Experiment Ops

    NASA Image and Video Library

    2014-08-22

    ISS040-E-104588 (22 Aug. 2014) --- In the International Space Station’s Rassvet Mini-Research Module 1 (MRM-1), Russian cosmonaut Maxim Suraev, Expedition 40 flight engineer, performs a session of the Calcium experiment, which examines the causes of the loss of bone density that occurs in a weightless environment. For this study, Russian researchers are looking at the solubility of calcium phosphates and human bone samples in water in space.

  20. STS-125 EVA OPS 1G training

    NASA Image and Video Library

    2009-04-09

    JSC2009-E-072675 (9 April 2009) --- Astronauts John Grunsfeld (right), Mike Massimino, Michael Good (background) and Andrew Feustel (out of frame), all STS-125 mission specialists, participate in a spacewalk training session in the Neutral Buoyancy Laboratory (NBL) near NASA's Johnson Space Center. Tomas Gonzalez-Torres (left foreground), STS-125 lead spacewalk officer, and United Space Alliance instructor Christy Hansen assisted the crewmembers.

  1. STS-125 EVA OPS 1G training

    NASA Image and Video Library

    2009-04-09

    JSC2009-E-072666 (9 April 2009) --- STS-125 crewmembers participate in a training session in the Neutral Buoyancy Laboratory (NBL) near NASA?s Johnson Space Center. Pictured (clockwise from the left) are astronaut Michael Good, mission specialist; United Space Alliance instructor Christy Hansen; astronaut Mike Massimino, mission specialist; Tomas Gonzalez-Torres, STS-125 lead spacewalk officer; astronaut Andrew Feustel and John Grunsfeld, both mission specialists.

  2. STS-125 EVA OPS 1G training

    NASA Image and Video Library

    2009-04-09

    JSC2009-E-072670 (9 April 2009) --- Astronauts Andrew Feustel (bottom), John Grunsfeld (center left), Mike Massimino and Michael Good (center, right), all STS-125 mission specialists, work with a Hubble Space Telescope mock-up during a spacewalk training session in the Neutral Buoyancy Laboratory (NBL) near NASA's Johnson Space Center. Tomas Gonzalez-Torres, STS-125 lead spacewalk officer, and United Space Alliance instructor Christy Hansen (mostly obscured) assisted the crewmembers.

  3. VLAP: results immediately post-op

    NASA Astrophysics Data System (ADS)

    Cowles, Robert S.

    1996-05-01

    Visual laser ablation of the prostate (VLAP) has been shown to be as effective with fewer complications than TURP in the treatment of bladder outlet obstruction secondary to benign prostatic hyperplasia. Questions have been raised about VLAP regarding prolonged irritative and obstructive voiding symptoms postoperatively. It is postulated that these symptoms are due to the slow slough of necrotic debris following VLAP. In an effort to improve upon the technique of VLAP, patients underwent lasing of the prostate in the routine manner (2, 4, 8, and 10 o'clock positions with sixty watts for sixty seconds) using Nd:YAG free beam energy. A bladder neck incision was then performed using a contact laser fiber. International prostate symptom score assessments were done preoperatively; one week and six weeks postoperatively. Post void residual urine volumes and prostate size were also evaluated. The findings indicate that symptom scores and post void residual urine volumes have significantly improved within ten days postoperatively using this technique.

  4. OPS laser EPI design for different wavelengths

    NASA Astrophysics Data System (ADS)

    Moloney, J. V.; Hader, J.; Li, H.; Kaneda, Y.; Wang, T. S.; Yarborough, M.; Koch, S. W.; Stolz, W.; Kunert, B.; Bueckers, C.; Chaterjee, S.; Hardesty, G.

    2009-02-01

    Design of optimized semiconductor optically-pumped semiconductor lasers (OPSLs) depends on many ingredients starting from the quantum wells, barrier and cladding layers all the way through to the resonant-periodic gain (RPG) and high reflectivity Bragg mirror (DBR) making up the OPSL active mirror. Accurate growth of the individual layers making up the RPG region is critical if performance degradation due to cavity misalignment is to be avoided. Optimization of the RPG+DBR structure requires knowledge of the heat generation and heating sinking of the active mirror. Nonlinear Control Strategies SimuLaseTM software, based on rigorous many-body calculations of the semiconductor optical response, allows for quantum well and barrier optimization by correlating low intensity photoluminescence spectra computed for the design, with direct experimentally measured wafer-level edge and surface PL spectra. Consequently, an OPSL device optimization procedure ideally requires a direct iterative interaction between designer and grower. In this article, we discuss the application of the many-body microscopic approach to OPSL devices lasing at 850nm, 1040nm and 2μm. The latter device involves and application of the many-body approach to mid-IR OPSLs based on antimonide materials. Finally we will present results on based on structural modifications of the epitaxial structure and/or novel material combinations that offer the potential to extend OPSL technology to new wavelength ranges.

  5. Creamer during T2 Relocation OPS

    NASA Image and Video Library

    2010-04-24

    ISS023-E-027160 (24 April 2010) --- NASA astronaut T.J. Creamer, Expedition 23 flight engineer, prepares the Combined Operational Load Bearing External Resistance Treadmill (COLBERT) for relocation from the Harmony node to its final place in the Tranquility node of the International Space Station.

  6. Dyson conducts SpaceDRUMS OPS

    NASA Image and Video Library

    2010-04-28

    ISS023-E-028753 (28 April 2010) --- NASA astronaut Tracy Caldwell Dyson, Expedition 23 flight engineer, services the SpaceDRUMS/Space Dynamically Responding Ultrasonic Matrix (SDRM) hardware in the Kibo laboratory of the International Space Station.

  7. Dyson conducts SpaceDRUMS OPS

    NASA Image and Video Library

    2010-04-28

    ISS023-E-028756 (28 April 2010) --- NASA astronaut Tracy Caldwell Dyson, Expedition 23 flight engineer, services the SpaceDRUMS/Space Dynamically Responding Ultrasonic Matrix (SDRM) hardware in the Kibo laboratory of the International Space Station.

  8. Dyson conducts SpaceDRUMS OPS

    NASA Image and Video Library

    2010-04-28

    ISS023-E-028754 (28 April 2010) --- NASA astronaut Tracy Caldwell Dyson, Expedition 23 flight engineer, services the SpaceDRUMS/Space Dynamically Responding Ultrasonic Matrix (SDRM) hardware in the Kibo laboratory of the International Space Station.

  9. Architectural Implications of DevOps

    DTIC Science & Technology

    2014-03-27

    Project Management Approach Size Metrics Years In Use Release Cadence CI Cadence A Agile/ Scrum (last 2 years and traditional before...that) 1M SLOC 17 Client release available every 2 months (not all accept it) Daily CI build B Water/ Scrum /F all 3M SLOC, team size 6– 8...90,000 users 3+ Internal release every 2–3 weeks, external release as needed Daily CI build C Agile/ Scrum Team size 30 2+ Internal release every

  10. The Art of Writing Op-Eds

    ERIC Educational Resources Information Center

    Kenney, Linda Chion

    2006-01-01

    When John Whritner was hired for his first superintendency, the school system he soon would lead had recently approved a town budget for education. By the time Whritner showed up for work in East Lyme, Conn., the fickle electorate had changed its collective mindset and reversed its approval by referendum. This article discusses how superintendents…

  11. Adding "Missed" Science to Cassini's Ops Plan

    NASA Technical Reports Server (NTRS)

    Roy, Mou; Burton, Marcia E.; Edgington, Scott; Pitesky, Jo E.; Steadman, Kimberly B.; Ray, Trina L.; Evans, Mike

    2014-01-01

    The phenomenal success of the Cassini Mission at Saturn is largely due to flagship instruments, in a target rich environment, for a long period of time, executing almost error free complex mission operations. A smooth transition from cruise operations through the prime science mission and extended science (Equinox) mission culminating in the currently executing Solstice mission has folded in necessary procedural alterations due to improved understanding of the spacecraft, instruments, uplink and planning systems as well as additional science objectives. These have come with the maturation of the mission along with management of workforce reductions. One important set of operational changes has been initiated due to scientific findings highlighting "missed" science opportunities. This is the case for the Titan Meteorology Campaigns and Saturn Storm Watch Campaigns. These observations involve long term monitoring of the atmospheres of Titan and Saturn while the spacecraft and science teams are focused on other high priority targets of opportunity (like Enceladus). Our objective in this paper is to emphasize how a non-invasive strategy to get additional remarkable science was conceived and implemented in a mission with an already well defined operational plan. To illustrate this we will detail Titan Meteorology Campaign and Saturn Storm Watch Campaign integration and implementation strategies as well as the scientific goals and achievements of both.

  12. Fischer and Whitson during Sprint Experiment OPS

    NASA Image and Video Library

    2017-05-03

    iss051e037012 (May 3, 2017) --- Flight engineer Jack Fischer dons Thigh and Calf Guides in preparation for Ultrasound 2 operations for the Integrated Resistance and Aerobic Training Study (Sprint) experiment. He is assisted by Commander Peggy Whitson. Image was taken in the Columbus European Laboratory.

  13. Adding "Missed" Science to Cassini's Ops Plan

    NASA Technical Reports Server (NTRS)

    Roy, Mou; Burton, Marcia E.; Edgington, Scott; Pitesky, Jo E.; Steadman, Kimberly B.; Ray, Trina L.; Evans, Mike

    2014-01-01

    The phenomenal success of the Cassini Mission at Saturn is largely due to flagship instruments, in a target rich environment, for a long period of time, executing almost error free complex mission operations. A smooth transition from cruise operations through the prime science mission and extended science (Equinox) mission culminating in the currently executing Solstice mission has folded in necessary procedural alterations due to improved understanding of the spacecraft, instruments, uplink and planning systems as well as additional science objectives. These have come with the maturation of the mission along with management of workforce reductions. One important set of operational changes has been initiated due to scientific findings highlighting "missed" science opportunities. This is the case for the Titan Meteorology Campaigns and Saturn Storm Watch Campaigns. These observations involve long term monitoring of the atmospheres of Titan and Saturn while the spacecraft and science teams are focused on other high priority targets of opportunity (like Enceladus). Our objective in this paper is to emphasize how a non-invasive strategy to get additional remarkable science was conceived and implemented in a mission with an already well defined operational plan. To illustrate this we will detail Titan Meteorology Campaign and Saturn Storm Watch Campaign integration and implementation strategies as well as the scientific goals and achievements of both.

  14. CIR Combustion Chamber Fuel Reservoir Ops

    NASA Image and Video Library

    2009-09-26

    ISS020-E-042198 (26 Sept. 2009) --- NASA astronaut Nicole Stott, Expedition 20 flight engineer, works with the Combustion Integrated Rack (CIR) in the Destiny laboratory of the International Space Station.

  15. CIR Combustion Chamber Fuel Reservoir Ops

    NASA Image and Video Library

    2009-09-26

    ISS020-E-042203 (26 Sept. 2009) --- NASA astronaut Nicole Stott, Expedition 20 flight engineer, works with the Combustion Integrated Rack (CIR) in the Destiny laboratory of the International Space Station.

  16. CIR Combustion Chamber Fuel Reservoir Ops

    NASA Image and Video Library

    2009-09-26

    ISS020-E-042207 (26 Sept. 2009) --- NASA astronaut Nicole Stott, Expedition 20 flight engineer, works with the Combustion Integrated Rack (CIR) in the Destiny laboratory of the International Space Station.

  17. Best Value Strategy: Raising Special Ops Mobility

    DTIC Science & Technology

    2015-06-01

    technologies, SORDAC pursued a best-value acquisition strategy to make the necessary trade- offs between technical capability, cost, and past performance...meant for SOF. The technical priorities, coupled with a short acquisition schedule, demonstrated the need for a nondevelopmental item (NDI) instead...performance attributes deemed unaffordable or technically immature at the program’s initiation, the FOSOV team pri- oritized and built a funding

  18. Fast pyrolysis of oil palm shell (OPS)

    NASA Astrophysics Data System (ADS)

    Abdullah, Nurhayati; Sulaiman, Fauziah; Aliasak, Zalila

    2015-04-01

    Biomass is an important renewable source of energy. Residues that are obtained from harvesting and agricultural products can be utilised as fuel for energy generation by conducting any thermal energy conversion technology. The conversion of biomass to bio oil is one of the prospective alternative energy resources. Therefore, in this study fast pyrolysis of oil palm shell was conducted. The main objective of this study was to find the optimum condition for high yield bio-oil production. The experiment was conducted using fixed-bed fluidizing pyrolysis system. The biomass sample was pyrolysed at variation temperature of 450°C - 650°C and at variation residence time of 0.9s - 1.35s. The results obtained were further discussed in this paper. The basic characteristic of the biomass sample was also presented here. The experiment shows that the optimum bio-oil yield was obtained at temperature of 500°C at residence time 1.15s.

  19. Mother Stephanie Mohun, O.P.

    ERIC Educational Resources Information Center

    Caspar, Ruth; Graham, Rosalie

    2006-01-01

    It is often stated that Catholic schools in the US were built on the foundation of the poverty of vowed women religious. Dozens of communities fit this description, none more so than the Dominican Sisters of St. Mary of the Springs. Sister Stephanie Mohun's service as mother general spanned a period of tremendous growth in Catholic education at…

  20. Op-Ed: Curriculum Implementation Revisited

    ERIC Educational Resources Information Center

    Tamir, Pinchas

    2004-01-01

    In 1978, more than 100 science educators from Israel and approximately 50 leading science educators and researchers representing 13 countries convened at the Weizmann Institute of Science, Rehovot (23-28 July) and The Hebrew University, Jerusalem (30 July-2 August) to discuss problems and issues of curriculum development and curriculum…

  1. Endeavour SRMS / OBSS during Survey OPS

    NASA Image and Video Library

    2010-02-09

    S130-E-005338 (8 Feb. 2010) --- Backdropped by the South China Sea and the Gulf of Tonkin, the Tranquility node in space shuttle Endeavour’s payload bay, vertical stabilizer, orbital maneuvering system (OMS) pods and a shadow-covered docking mechanism are featured in this image photographed by the STS-130 crew from an aft flight deck window. Hainan Island can be seen between the South China Sea (bottom) and Gulf of Tonkin (top). The Leizhou Peninsula of the Chinese mainland is on the upper right.

  2. Kelly and Lindgren conduct EMU Resize OPS

    NASA Image and Video Library

    2015-10-07

    ISS045E050652 (10/07/2015) --- US astronauts Scott Kelly (bottom)and Kjell Lindgren (top) are counting down to a pair of spacewalks, now targeted for Oct. 28 and Nov. 6. The duo serviced their spacesuits replacing lithium batteries, checking their gloves and verifying power to video cameras. On the first spacewalk, the spacewalkers will lubricate the tip of the robotic arm Canadarm2, route power cables and place a thermal shroud over the Alpha Magnetic Spectrometer. During the second spacewalk, Kelly and Lindgren will refill coolant reservoirs and configure the port truss cooling system back to its original configuration after repair work completed back in 2012.

  3. Hernandez on Flight Deck during Approach OPS

    NASA Image and Video Library

    2009-08-31

    S128-E-006982 (30 Aug. 2009) --- Astronaut John “Danny” Olivas (left), STS-128 mission specialist, uses a handheld laser ranging device at an overhead window on the aft flight deck of the Space Shuttle Discovery to track the range of the International Space Station during rendezvous operations. Astronaut Jose Hernandez, mission specialist, uses a computer at right.

  4. Op-Ed: Curriculum Implementation Revisited

    ERIC Educational Resources Information Center

    Tamir, Pinchas

    2004-01-01

    In 1978, more than 100 science educators from Israel and approximately 50 leading science educators and researchers representing 13 countries convened at the Weizmann Institute of Science, Rehovot (23-28 July) and The Hebrew University, Jerusalem (30 July-2 August) to discuss problems and issues of curriculum development and curriculum…

  5. The Art of Writing Op-Eds

    ERIC Educational Resources Information Center

    Kenney, Linda Chion

    2006-01-01

    When John Whritner was hired for his first superintendency, the school system he soon would lead had recently approved a town budget for education. By the time Whritner showed up for work in East Lyme, Conn., the fickle electorate had changed its collective mindset and reversed its approval by referendum. This article discusses how superintendents…

  6. Tonsillectomy and Adenoids PostOp

    MedlinePlus

    ... Copyright © 2017 American Academy of Otolaryngology–Head and Neck Surgery. Reproduction or republication strictly prohibited without prior written ... Copyright 2017. American Academy of Otolaryngology — Head and Neck Surgery 1650 Diagonal Rd Alexandria, VA 22314 tel (703) ...

  7. A brief intervention for drug use, sexual risk behaviours and violence prevention with vulnerable women in South Africa: a randomised trial of the Women’s Health CoOp

    PubMed Central

    Wechsberg, Wendee M; Jewkes, Rachel; Novak, Scott P; Kline, Tracy; Myers, Bronwyn; Browne, Felicia A; Carney, Tara; Morgan Lopez, Antonio A; Parry, Charles

    2013-01-01

    Objective To assess the impact of the Women's Health CoOp (WHC) on drug abstinence among vulnerable women having HIV counselling and testing (HCT). Design Randomised trial conducted with multiple follow-ups. Setting 15 communities in Cape Town, South Africa. Participants 720 drug-using women aged 18–33, randomised to an intervention (360) or one of two control arms (181 and 179) with 91.9% retained at follow-up. Interventions The WHC brief peer-facilitated intervention consisted of four modules (two sessions), 2 h addressing knowledge and skills to reduce drug use, sex risk and violence; and included role-playing and rehearsal, an equal attention nutrition intervention, and an HCT-only control. Primary outcome measures Biologically confirmed drug abstinence measured at 12-month follow-up, sober at last sex act, condom use with main and casual sex partners, and intimate partner violence. Results At the 12-month endpoint, 26.9% (n=83/309) of the women in the WHC arm were abstinent from drugs, compared with 16.9% (n=27/160) in the Nutrition arm and 20% (n=31/155) in the HCT-only control arm. In the random effects model, this translated to an effect size on the log odds scale with an OR of 1.54 (95% CI 1.07 to 2.22) comparing the WHC arm with the combined control arms. Other 12-month comparison measures between arms were non-significant for sex risk and victimisation outcomes. At 6-month follow-up, women in the WHC arm (65.9%, 197/299) were more likely to be sober at the last sex act (OR1.32 (95% CI 1.02 to 1.84)) than women in the Nutrition arm (54.3%, n=82/152). Conclusions This is the first trial among drug-using women in South Africa showing that a brief intervention added to HCT results in greater abstinence from drug use at 12 months and a larger percentage of sexual activity not under the influence of substances. Trial registration number NCT00729391 ClinicalTrials.gov PMID:23793683

  8. A randomized, multicenter, pilot study comparing the efficacy and safety of a bupivacaine-collagen implant (XaraColl(®)) with the ON-Q PainBuster(®) Post-op Pain Relief System following open gynecological surgery.

    PubMed

    Cusack, Susan L; Minkowitz, Harold S; Kuss, Michael; Jaros, Mark; Hemsen, Lisa

    2012-01-01

    XaraColl(®), a collagen-based intraoperative implant that delivers bupivacaine to the site of surgical trauma, is under development for postoperative analgesia. We compared the efficacy and safety of XaraColl for the prevention of postsurgical pain versus a slow postoperative perfusion of bupivacaine to the wound environment via the ON-Q PainBuster(®) Post-op Pain Relief System (ON-Q). We randomized 27 women undergoing open gynecological surgery to receive either three XaraColl implants (each containing 50 mg bupivacaine hydrochloride) or ON-Q (900 mg bupivacaine hydrochloride perfused over 72 hours) in a 1:1 ratio. Following surgery, patients had access to intravenous morphine via a patient-controlled analgesia pump as rescue analgesia for the first 24 hours and to oral opioid medication thereafter. Total use of opioid analgesia was compared through 24, 48, 72, and 96 hours after surgery. Patients also evaluated overall pain control over the 96-hour period using a five-point numeric rating scale. Safety was assessed for 30 days after surgery. XaraColl was non-inferior to ON-Q in total use of opioid analgesia for the first 24, 48, 72, and 96 hours after surgery, with a statistical trend towards reduced opioid use in favor of XaraColl over 24, 48, and 72 hours (P = 0.067, 0.100, and 0.089, respectively). The time to first use of opioid analgesia was also significantly delayed in patients treated with XaraColl (P = 0.024). There was no significant difference between groups in patients' evaluation of pain control or their satisfaction with the treatment in general. Both treatments were considered safe and well tolerated. Despite using only 17% of the ON-Q dose, XaraColl is as effective as ON-Q in providing postoperative analgesia for 4 days after open gynecological surgery. These preliminary findings suggest that XaraColl offers great potential for the management of postoperative pain and warrants further definitive studies.

  9. A randomized, multicenter, pilot study comparing the efficacy and safety of a bupivacaine-collagen implant (XaraColl®) with the ON-Q PainBuster® Post-op Pain Relief System following open gynecological surgery

    PubMed Central

    Cusack, Susan L; Minkowitz, Harold S; Kuss, Michael; Jaros, Mark; Hemsen, Lisa

    2012-01-01

    Background XaraColl®, a collagen-based intraoperative implant that delivers bupivacaine to the site of surgical trauma, is under development for postoperative analgesia. We compared the efficacy and safety of XaraColl for the prevention of postsurgical pain versus a slow postoperative perfusion of bupivacaine to the wound environment via the ON-Q PainBuster® Post-op Pain Relief System (ON-Q). Methods We randomized 27 women undergoing open gynecological surgery to receive either three XaraColl implants (each containing 50 mg bupivacaine hydrochloride) or ON-Q (900 mg bupivacaine hydrochloride perfused over 72 hours) in a 1:1 ratio. Following surgery, patients had access to intravenous morphine via a patient-controlled analgesia pump as rescue analgesia for the first 24 hours and to oral opioid medication thereafter. Total use of opioid analgesia was compared through 24, 48, 72, and 96 hours after surgery. Patients also evaluated overall pain control over the 96-hour period using a five-point numeric rating scale. Safety was assessed for 30 days after surgery. Results XaraColl was non-inferior to ON-Q in total use of opioid analgesia for the first 24, 48, 72, and 96 hours after surgery, with a statistical trend towards reduced opioid use in favor of XaraColl over 24, 48, and 72 hours (P = 0.067, 0.100, and 0.089, respectively). The time to first use of opioid analgesia was also significantly delayed in patients treated with XaraColl (P = 0.024). There was no significant difference between groups in patients’ evaluation of pain control or their satisfaction with the treatment in general. Both treatments were considered safe and well tolerated. Conclusion Despite using only 17% of the ON-Q dose, XaraColl is as effective as ON-Q in providing postoperative analgesia for 4 days after open gynecological surgery. These preliminary findings suggest that XaraColl offers great potential for the management of postoperative pain and warrants further definitive studies. PMID

  10. OP09O-OP404-9 Wide Field Camera 3 CCD Quantum Efficiency Hysteresis

    NASA Technical Reports Server (NTRS)

    Collins, Nick

    2009-01-01

    The HST/Wide Field Camera (WFC) 3 UV/visible channel CCD detectors have exhibited an unanticipated quantum efficiency hysteresis (QEH) behavior. At the nominal operating temperature of -83C, the QEH feature contrast was typically 0.1-0.2% or less. The behavior was replicated using flight spare detectors. A visible light flat-field (540nm) with a several times full-well signal level can pin the detectors at both optical (600nm) and near-UV (230nm) wavelengths, suppressing the QEH behavior. We are characterizing the timescale for the detectors to become unpinned and developing a protocol for flashing the WFC3 CCDs with the instrument's internal calibration system in flight. The HST/Wide Field Camera 3 UV/visible channel CCD detectors have exhibited an unanticipated quantum efficiency hysteresis (QEH) behavior. The first observed manifestation of QEH was the presence in a small percentage of flat-field images of a bowtie-shaped contrast that spanned the width of each chip. At the nominal operating temperature of -83C, the contrast observed for this feature was typically 0.1-0.2% or less, though at warmer temperatures contrasts up to 5% (at -50C) have been observed. The bowtie morphology was replicated using flight spare detectors in tests at the GSFC Detector Characterization Laboratory by power cycling the detector while cold. Continued investigation revealed that a clearly-related global QE suppression at the approximately 5% level can be produced by cooling the detector in the dark; subsequent flat-field exposures at a constant illumination show asymptotically increasing response. This QE "pinning" can be achieved with a single high signal flat-field or a series of lower signal flats; a visible light (500-580nm) flat-field with a signal level of several hundred thousand electrons per pixel is sufficient for QE pinning at both optical (600nm) and near-UV (230nm) wavelengths. We are characterizing the timescale for the detectors to become unpinned and developing a protocol for flashing the WFC3 CCDs with the instrument's internal calibration system in flight. A preliminary estimate of the decay timescale for one detector is that a drop of 0.1-0.2% occurs over a ten day period, indicating that relatively infrequent cal lamp exposures can mitigate the behavior to extremely low levels.

  11. OP09O-OP404-9 Wide Field Camera 3 CCD Quantum Efficiency Hysteresis

    NASA Technical Reports Server (NTRS)

    Collins, Nick

    2009-01-01

    The HST/Wide Field Camera (WFC) 3 UV/visible channel CCD detectors have exhibited an unanticipated quantum efficiency hysteresis (QEH) behavior. At the nominal operating temperature of -83C, the QEH feature contrast was typically 0.1-0.2% or less. The behavior was replicated using flight spare detectors. A visible light flat-field (540nm) with a several times full-well signal level can pin the detectors at both optical (600nm) and near-UV (230nm) wavelengths, suppressing the QEH behavior. We are characterizing the timescale for the detectors to become unpinned and developing a protocol for flashing the WFC3 CCDs with the instrument's internal calibration system in flight. The HST/Wide Field Camera 3 UV/visible channel CCD detectors have exhibited an unanticipated quantum efficiency hysteresis (QEH) behavior. The first observed manifestation of QEH was the presence in a small percentage of flat-field images of a bowtie-shaped contrast that spanned the width of each chip. At the nominal operating temperature of -83C, the contrast observed for this feature was typically 0.1-0.2% or less, though at warmer temperatures contrasts up to 5% (at -50C) have been observed. The bowtie morphology was replicated using flight spare detectors in tests at the GSFC Detector Characterization Laboratory by power cycling the detector while cold. Continued investigation revealed that a clearly-related global QE suppression at the approximately 5% level can be produced by cooling the detector in the dark; subsequent flat-field exposures at a constant illumination show asymptotically increasing response. This QE "pinning" can be achieved with a single high signal flat-field or a series of lower signal flats; a visible light (500-580nm) flat-field with a signal level of several hundred thousand electrons per pixel is sufficient for QE pinning at both optical (600nm) and near-UV (230nm) wavelengths. We are characterizing the timescale for the detectors to become unpinned and developing a protocol for flashing the WFC3 CCDs with the instrument's internal calibration system in flight. A preliminary estimate of the decay timescale for one detector is that a drop of 0.1-0.2% occurs over a ten day period, indicating that relatively infrequent cal lamp exposures can mitigate the behavior to extremely low levels.

  12. A Behavior Focused Assessment of Co-Op Performance: A Comparison of Co-Op and Non-Co-Op Graduating Students

    ERIC Educational Resources Information Center

    Pennaforte, Antoine

    2016-01-01

    This paper investigates how student-workers' performance can be assessed through the notion of work-role performance, on the basis of three behavioral-related dimensions (proficiency, adaptivity, and proactivity), and proposes a definition of performance prior to graduation. By taking into account the accumulation of work experience, this article…

  13. Nine co-localized cytochrome P450 genes of the CYP2N, CYP2AD, and CYP2P gene families in the mangrove killifish Kryptolebias marmoratus genome: Identification and expression in response to B[α]P, BPA, OP, and NP.

    PubMed

    Puthumana, Jayesh; Kim, Bo-Mi; Jeong, Chang-Bum; Kim, Duck-Hyun; Kang, Hye-Min; Jung, Jee-Hyun; Kim, Il-Chan; Hwang, Un-Ki; Lee, Jae-Seong

    2017-06-01

    The CYP2 genes are the largest and most diverse cytochrome P450 (CYP) subfamily in vertebrates. We have identified nine co-localized CYP2 genes (∼55kb) in a new cluster in the genome of the highly resilient ecotoxicological fish model Kryptolebias marmoratus. Molecular characterization, temporal and tissue-specific expression pattern, and response to xenobiotics of these genes were examined. The CYP2 gene clusters were characterized and designated CYP2N22-23, CYP2AD12, and CYP2P16-20. Gene synteny analysis confirmed that the cluster in K. marmoratus is similar to that found in other teleost fishes, including zebrafish. A gene duplication event with diverged catalytic function was observed in CYP2AD12. Moreover, a high level of divergence in expression was observed among the co-localized genes. Phylogeny of the cluster suggested an orthologous relationship with similar genes in zebrafish and Japanese medaka. Gene expression analysis showed that CYP2P19 and CYP2N20 were consecutively expressed throughout embryonic development, whereas CYP2P18 was expressed in all adult tissues, suggesting that members of each CYP2 gene family have different physiological roles even though they are located in the same cluster. Among endocrine-disrupting chemicals (EDCs), benzo[α]pyrene (B[α]P) induced expression of CYP2N23, bisphenol A (BPA) induced CYP2P18 and CYP2P19, and 4-octylphenol (OP) induced CYP2AD12, but there was no significant response to 4-nonylphenol (NP), implying differential catalytic roles of the enzyme. In this paper, we identify and characterize a CYP2 gene cluster in the mangrove killifish K. marmoratus with differing catalytic roles toward EDCs. Our findings provide insights on the roles of nine co-localized CYP2 genes and their catalytic functions for better understanding of chemical-biological interactions in fish. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. OP-AMPS on Flexible Substrates with Printable Materials

    DTIC Science & Technology

    2011-08-10

    release transport model. V. REFERENCES [1] D. P. Heineck, B. R. McFarlane , and J. F. Wager, "Zinc Tin Oxide Thin-Film-Transistor Enhancement...Materials for Advanced Technologies (ICMAT), Singapore, June 21-July 1, 2011. (INVITED) Chen-Guan Lee, Cobb Brian and Ananth Dodabalapur, “Charge

  15. Flight Planning Branch NASA Co-op Tour

    NASA Technical Reports Server (NTRS)

    Marr, Aja M.

    2013-01-01

    This semester I worked with the Flight Planning Branch at the NASA Johnson Space Center. I learned about the different aspects of flight planning for the International Space Station as well as the software that is used internally and ISSLive! which is used to help educate the public on the space program. I had the opportunity to do on the job training in the Mission Control Center with the planning team. I transferred old timeline records from the planning team's old software to the new software in order to preserve the data for the future when the software is retired. I learned about the operations of the International Space Station, the importance of good communication between the different parts of the planning team, and enrolled in professional development classes as well as technical classes to learn about the space station.

  16. Optoelectronic Device Integration in Silicon (OpSIS)

    DTIC Science & Technology

    2015-10-26

    community of users for these processes, in order to enable the creation of a multi-project- wafer infrastructure for silicon photonics. 15. SUBJECT TERMS...multi-project- wafer infrastructure for silicon photonics. II. Summary of Results The research goals began as a program centered on creating a...electronic, system-on-chip development. For this, a platform with both photodetectors and modulators working at high speeds, with excellent cross- wafer

  17. STS-124 EVA 3 Nitrogen Tank Assembly (NTA) OPS

    NASA Image and Video Library

    2008-06-08

    ISS017-E-009220 (8 June 2008) --- Anchored to a Canadarm2 mobile foot restraint, astronaut Ron Garan, STS-124 mission specialist, participates in the mission's third scheduled session of extravehicular activity (EVA) as construction and maintenance continue on the International Space Station. During the six-hour, 33-minute spacewalk, Garan and astronaut Mike Fossum (out of frame), mission specialist, exchanged a depleted Nitrogen Tank Assembly for a new one, removed thermal covers and launch locks from the Kibo laboratory, reinstalled a repaired television camera onto the space station's left P1 truss, and retrieved samples of a dust-like substance from the left Solar Alpha Rotary Joint for analysis by experts on the ground.

  18. Resonance Ops: How Developing Social Movements Can Operationalize Ideologies

    DTIC Science & Technology

    2016-12-01

    a communication pathway with resonant messages for the intended audiences. After studying ideologies and social movements as domestic and...meme, harmonic, antenna, influence, communication, information, pathway, consciousness, interpretation, bias, fallacy, violence , war 15. NUMBER OF...resonant messages for the intended audiences. After studying ideologies and social movements as domestic and international phenomena, my

  19. Op. Amps in Power Amplification: A Laboratory Exercise on Feedback.

    ERIC Educational Resources Information Center

    Borcherds, P. H.

    1984-01-01

    To demonstrate negative feedback a power amplifier is constructed from an operational amplifier together with a complementary pair of transistors as an output stage. The amplifier is developed and tested stage by stage, and at each stage the defects apparent at the previous stage are eliminated. (JN)

  20. Grand mission versus small OPS team: Can we have both?

    NASA Technical Reports Server (NTRS)

    Garcia-Perez, Raul

    1994-01-01

    Space Missions are growing more ambitious, but resources are getting smaller. Is this is a contradiction in terms, or is it a healthy challenge? This paper offers the author's point of view as a member of a small Mission Operations Team that carries out an ambitious international mission (Ulysses ESA/NASA).

  1. Neuroprotection From Op-Induced Seizures and Neuropathology.

    DTIC Science & Technology

    1999-03-01

    relative levels of NR subunits in the PC and other cortical regions. The comparative expressions of NR1, NR2A, NR2B , NR2C, NR2D and NR3 subunits were...analyzed in the PC, entorhinal, visual and motor cortices, and the olfactory bulb. This analysis showed that NR2B was the most heavily expressed subunit...in all of the brain regions examined. These results suggest that NR2B is an important component of the NRs while NR2C, NR2D and NR-L are not

  2. Tera-OP Reliable Intelligently Adaptive Processing System (TRIPS) Implementation

    DTIC Science & Technology

    2008-09-01

    completion 72 External Store (ESN) L1 misses 10 Operand Network (OPN) Operand routing 141 (×8) On-chip Network (OCN) Memory traffic 138 (×8) 4.3.2 Distributed...of Augmenting Topologies (NEAT) to generate cost functions. NEAT uses a genetic algorithm to evolve neural networks [64]. We trained NEAT on each...bound programs. For the operand network , we measure traffic load to determine how well the compiler’s placement algorithm minimizes the distance

  3. Positioning the Co-op Program for Maximum Marketing Effectiveness.

    ERIC Educational Resources Information Center

    Harris, Ronald R.

    1983-01-01

    Examines the concept of positioning, which is the way that individuals perceive and are made aware of a program and believe in its benefit to them and its application to cooperative education programs. Includes a five-step plan for assessing the position of cooperative programs and six ways to implement a positioning strategy. (JOW)

  4. Teton Coin Op Laundry: heat recovery unit. Final report

    SciTech Connect

    Not Available

    1984-01-16

    Experience with a heat recovery unit using Freon 11 refrigerant as a transfer medium is reported. Heat exchangers were fabricated for use in dryer stacks and the waste heat was used in heating the water for the laundry. (MHR)

  5. School Co-ops and Shared Media Services

    ERIC Educational Resources Information Center

    Miller, Thomas E.

    1973-01-01

    Examines shared services through school system cooperatives as one of the most promising alternatives to the reorganization of small school districts. Criteria are proposed for selection of services to be shared. Nine types of media services are discussed that could be provided appropriately through school cooperatives. (Author/WM)

  6. Cassidy conducts MDCA Fuel Reservoir Remove and Replace OPS

    NASA Image and Video Library

    2013-04-10

    ISS035-E-017712 (10 April 2013)?-- This is one of several photos documenting the Multi-user Droplet Combustion Apparatus (MDCA) Fuel Reservoir replacement in the U.S. lab Destiny. Here, Expedition 35 Flight Engineer Chris Cassidy removes and replaces one of the Fuel Reservoirs with the MDCA Chamber Insert Assembly (CIA) pulled partially out of the Combustion Chamber. The MDCA Fuel Reservoirs contain the liquid fuel used during droplet combustion experiments. This reservoir change-out was in support of the FLame EXtinguishment (FLEX)-2 experiment, scheduled to be executed by ground controllers.

  7. Cassidy conducts MDCA Fuel Reservoir Remove and Replace OPS

    NASA Image and Video Library

    2013-04-10

    ISS035-E-017699 (10 April 2013) --- This is one of several photos documenting the Multi-user Droplet Combustion Apparatus (MDCA) Fuel Reservoir replacement. Here, Expedition 35 Flight Engineer Chris Cassidy removes and replaces one of the Fuel Reservoirs with the MDCA Chamber Insert Assembly (CIA) pulled partially out of the Combustion Chamber. The MDCA Fuel Reservoirs contain the liquid fuel used during droplet combustion experiments. This reservoir change-out was in support of the FLame EXtinguishment (FLEX)-2 experiment, scheduled to be executed by ground controllers.

  8. The UConn Co-op Building and Ray Verrey.

    ERIC Educational Resources Information Center

    White, Ken

    1982-01-01

    The planning and merchandising strategies behind a new cooperative college store building and customer circulation concept are outlined. The facility allows for both current marketing needs and future flexibility as the store expands its role. (MSE)

  9. STS-131 EVA 2 S1 ATA Relocation OPS

    NASA Image and Video Library

    2010-04-11

    S131-E-008708 (11 April 2010) --- NASA astronaut Rick Mastracchio (left) and Clayton Anderson, both STS-131 mission specialists, participate in the mission's second session of extravehicular activity (EVA) as construction and maintenance continue on the International Space Station. During the seven-hour, 26-minute spacewalk, Mastracchio and Anderson unhooked and removed the depleted ammonia tank and installed a 1,700-pound ammonia tank on the station?s Starboard 1 truss, completing the second of a three-spacewalk coolant tank replacement process.

  10. STS-131 EVA 2 S1 ATA Relocation OPS

    NASA Image and Video Library

    2010-04-11

    S131-E-008710 (11 April 2010) --- NASA astronauts Rick Mastracchio (left) and Clayton Anderson, both STS-131 mission specialists, participate in the mission's second session of extravehicular activity (EVA) as construction and maintenance continue on the International Space Station. During the seven-hour, 26-minute spacewalk, Mastracchio and Anderson unhooked and removed the depleted ammonia tank and installed a 1,700-pound ammonia tank on the station?s Starboard 1 truss, completing the second of a three-spacewalk coolant tank replacement process.

  11. STS-131 EVA 2 S1 ATA Relocation OPS

    NASA Image and Video Library

    2010-04-11

    S131-E-008700 (11 April 2010) --- NASA astronaut Rick Mastracchio (bottom) and Clayton Anderson, both STS-131 mission specialists, participate in the mission's second session of extravehicular activity (EVA) as construction and maintenance continue on the International Space Station. During the seven-hour, 26-minute spacewalk, Mastracchio and Anderson unhooked and removed the depleted ammonia tank and installed a 1,700-pound ammonia tank on the station?s Starboard 1 truss, completing the second of a three-spacewalk coolant tank replacement process.

  12. STS-131 EVA 2 S1 ATA Relocation OPS

    NASA Image and Video Library

    2010-04-11

    S131-E-008953 (11 April 2010) --- NASA astronauts Rick Mastracchio (left) and Clayton Anderson, both STS-131 mission specialists, participate in the mission's second session of extravehicular activity (EVA) as construction and maintenance continue on the International Space Station. During the seven-hour, 26-minute spacewalk, Mastracchio and Anderson unhooked and removed the depleted ammonia tank and installed a 1,700-pound ammonia tank on the station?s Starboard 1 truss, completing the second of a three-spacewalk coolant tank replacement process.

  13. STS-131 EVA 2 S1 ATA Relocation OPS

    NASA Image and Video Library

    2010-04-11

    S131-E-008964 (11 April 2010) --- NASA astronauts Rick Mastracchio (left) and Clayton Anderson, both STS-131 mission specialists, participate in the mission's second session of extravehicular activity (EVA) as construction and maintenance continue on the International Space Station. During the seven-hour, 26-minute spacewalk, Mastracchio and Anderson unhooked and removed the depleted ammonia tank and installed a 1,700-pound ammonia tank on the station?s Starboard 1 truss, completing the second of a three-spacewalk coolant tank replacement process.

  14. STS-131 EVA 2 S1 ATA Relocation OPS

    NASA Image and Video Library

    2010-04-11

    S131-E-008704 (11 April 2010) --- NASA astronaut Clayton Anderson, STS-131 mission specialist, participates in the mission's second session of extravehicular activity (EVA) as construction and maintenance continue on the International Space Station. During the seven-hour, 26-minute spacewalk, Anderson and Rick Mastracchio (out of frame), mission specialist, unhooked and removed the depleted ammonia tank and installed a 1,700-pound ammonia tank on the station?s Starboard 1 truss, completing the second of a three-spacewalk coolant tank replacement process.

  15. STS-131 EVA 2 S1 ATA Relocation OPS

    NASA Image and Video Library

    2010-04-11

    S131-E-008878 (11 April 2010) --- NASA astronauts Rick Mastracchio (left) and Clayton Anderson, both STS-131 mission specialists, participate in the mission's second session of extravehicular activity (EVA) as construction and maintenance continue on the International Space Station. During the seven-hour, 26-minute spacewalk, Mastracchio and Anderson unhooked and removed the depleted ammonia tank and installed a 1,700-pound ammonia tank on the station?s Starboard 1 truss, completing the second of a three-spacewalk coolant tank replacement process. The thin line of Earth's atmosphere appears in frame center.

  16. A combined experimental setup for OP and ODNMR

    NASA Astrophysics Data System (ADS)

    Sesti, Erika L.; Willmering, Matthew M.; Ma, Zayd L.; Wheeler, Dustin D.; Conradi, Mark S.; Hayes, Sophia E.

    2017-08-01

    Instrumentation for optically-pumped and optically-detected nuclear magnetic resonance (OPNMR and ODNMR) has been developed and implemented as a single experimental apparatus to study semiconductors such as GaAs and CdTe. These two measurement schemes use many of the same components for experiments. Here we describe, in two parts, the apparatus that can record such measurements and give examples of representative data. In Part 1, the radio-frequency probe and low-temperature cryostat are described, including single-channel and two-channel static cryogenic probes that both incorporate a modified solenoid coil that permits better optical access. In Part 2, the optical bench is described in detail, which uses a set of experiments (magneto-photoluminescence, photoluminescence excitation, detection of polarized photoluminescence) as important input for ODNMR. We are able to portray a robust design that encompasses multiple measurement modalities, along with the ability to change many experimental parameters with ease.

  17. Thomas uses laser range finder during rendezvous ops

    NASA Image and Video Library

    2001-03-10

    STS102-E-5064 (10 March 2001) --- Astronaut Andrew S.W. Thomas, STS-102 mission specialist, uses a laser ranging device on aft flight deck of the Space Shuttle Discovery. This instrument is a regularly called-on tool during rendezvous operations with the International Space Station (ISS). The photograph was recorded with a digital still camera.

  18. Usachev uses a laser range finder during rendezvous ops

    NASA Image and Video Library

    2001-03-10

    STS102-E-5085 (10 March 2001) --- Cosmonaut Yury V. Usachev, STS-102 mission specialist, uses a laser ranging device on Discovery's aft flight deck during rendezvous operations. The photograph was recorded with a digital still camera.

  19. Interactive telemedical applications in OP 2000 via satellite.

    PubMed

    Graschew, Georgi; Roelofs, Theo A; Rakowsky, Stefan; Schlag, Peter M

    2002-01-01

    Using off-the-shelf hardware components and a specially developed high-end software communication system (WinVicos) satellite networks for interactive telemedicine have been designed and developed. These networks allow for various telemedical applications, like teleteaching, telementoring, intraoperative teleconsultation, second opinioning, etc.. Based on the successful GALENOS network, several projects are currently being realized: MEDASHIP (Medical Assistance for Ships); DELTASS (Disaster Emergency Logistic Telemedicine Advanced Satellites Systems) and EMISPHER (Euro-Mediterranean Internet-Satellite Platform for Health, medical Education and Research).

  20. Mastracchio during EMU FPS Remove and Replace OPS

    NASA Image and Video Library

    2014-04-14

    Expedition 39 flight engineer Rick Mastracchio poses for a photo with the replacement Fan Pump Separator (FPS) and Extravehicular Mobility Unit (EMU) 3005. Image was taken in the Quest Airlock (A/L) during FPS remove and replace operations.